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Background: Global DNA hypomethylation is an early molecular event in carcinogenesis. Whether methylation measured in peripheral blood mononuclear cells (PBMCs) DNA is a clinically reliable biomarker for early detection or cancer risk assessment is to be established.
Methods: From an original sample-set of 753 male and female adults (ages 64.8 ± 7.3 years), PBMCs DNA methylation was measured in 68 subjects with history of cancer at time of enrollment and 62 who developed cancer during follow-up. Age- and sex-matched controls for prevalent and incident cancer cases (n = 68 and 58, respectively) were also selected. Global DNA methylation was assessed by liquid chromatography/mass spectrometry (LC/MS). Methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype and plasma folate concentrations were also determined for the known gene-nutrient interaction affecting DNA methylation.
Results: Cancer subjects had significantly lower PBMCs-DNA methylation than controls [4.39 (95% confidence intervals (CI), 4.25–4.53) vs. 5.13 (95% CI, 5.03–5.21) %mCyt/(mCyt+Cyt); P < 0.0001]. A DNA methylation threshold of 4.74% clearly categorized patients with cancer from controls so that those with DNA methylation less than 4.74% showed an increased prevalence of cancer than those with higher levels (91.5% vs. 19%; P < 0.001). Subjects with cancer at follow-up had, already at enrollment, reduced DNA methylation as compared with controls [4.34 (95% CI, 4.24–4.51) vs. 5.08 (95% CI, 5.05–5.22) %mCyt/(mCyt+Cyt); P < 0.0001]. Moreover, MTHFR677C>T genotype and folate interact for determining DNA methylation, so that MTHFR677TT carriers with low folate had the lowest DNA methylation and concordantly showed a higher prevalence of cancer history (OR, 7.04; 95% CI, 1.52–32.63; P = 0.013).
Conclusions: Genomic PBMCs-DNA methylation may be a useful epigenetic biomarker for early detection and cancer risk estimation.
Impact: This study identifies a threshold for PBMCs-DNA methylation to detect cancer-affected from cancer-free subjects and an at-risk condition for cancer based on genomic DNA methylation and MTHFR677C>T-folate status. Cancer Epidemiol Biomarkers Prev; 22(3); 348–55. ©2012 AACR.
DNA methylation is an epigenetic phenomenon that affects the regulation of gene expression and genome integrity (1). Aberrant DNA methylation is a critical mechanism for carcinogenesis (2, 3). Global DNA hypomethylation is an almost universal finding in many human cancer tissues (4) and cancer precursor cells (5), and many studies in rodent models showed that global DNA hypomethylation can, by itself, induce cancer (6). However, it is yet unclear whether this common epigenetic feature can be a clinically functional biomarker or even a screening tool to identify patients affected by cancer disease. A stimulating scientific debate is indeed ongoing to clarify the usefulness of genomic methylation status in DNA obtained from an easily accessible tissue in humans such as peripheral blood mononuclear cells (PBMC) as a suitable biomarker even for cancer tissue of different origin (7).
Differently from mutations and LOH, DNA methylation is a reversible phenomenon (8, 9) and it can be modified by nutrients such as folate (10) as well as influenced by the common 677C>T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene (11, 12). An interaction between folate status and the MTHFR variant can affect global DNA methylation (11), and thereby potentially modify the risk of cancer. The polymorphic MTHFR677C>T favors the reduction of the 5-methyltetrahydrofolate (5-methylTHF) proportion in tissue folate pool (11), and at the low folate status individuals carrying the MTHFR677C>T homozygous variant genotype (677TT) have a decreased global DNA methylation (11, 12), which may induce molecular modifications in the cell eventually leading toward the development of cancer (13). Most recently, DNA methylation has been tested in blood as a circulating tumor cell DNA marker (14) and a number of studies evaluated the possible role of circulating white blood cells DNA methylation in different types of cancer as a potential marker to define the risk for malignancies of different tissue origin (7, 15–18).
We, therefore, set out to determine whether global hypomethylation in PBMCs DNA can indicate the presence of cancer or impending cancer development.
Materials and Methods
Study subjects
From an original sample-set of 753 subjects of both sexes and mean age of 64.8 ± 7.3 years, who were recruited from a single geographic area in Italy with a similar socioeconomic background in which they were previously engaged from 1996 to 2004 for a cardiovascular risk factors study (19, 20), we retrospectively evaluated the clinical history for cancer diagnosis and selected 68 subjects who were diagnosed of cancer at the time of enrollment in the study and 62 subjects who developed cancer during an 8-year follow-up period, along with 68 age- and sex-matched controls at enrollment and 58 age- and sex-matched controls, at follow-up. Clinical history of the subjects referring to cancer disease was obtained by search within the national population register, and by an ambulatory or a telephone-administered survey conducted by a physician. The causes of death including cancer were obtained from death certificates kept at the Italian Institute of Statistics (ISTAT; Rome, Italy). This study was approved by the University Hospital of Verona Ethical Review Boards and informed consent was obtained from all subjects after full explanation of the study.
Specimen characteristics
Samples of peripheral venous blood were drawn in EDTA-containing BD Vacutainer tubes from each subject after an overnight fast, before proceeding for plasma as well as DNA extraction. Plasma was accurately stored at −80°C before analyses.
Assay methods
DNA was extracted from PBMCs by Wizard Genomic DNA Purification Kit (Promega Corporation) and global DNA methylation, expressed as percentage (%) 5-methylcytosine (mCyt)/(mCyt + Cyt), was determined using a liquid chromatography/mass spectrometry (LC/MS) method, as we previously described (11, 21). Percentage relative SDs for method precision of 1.9 (within-day) and 1.7 (day-to-day; ref. 21). Plasma folate concentrations were measured by an automated chemiluminescence method (Chiron Diagnostics) having an intra-assay and interassay coefficients of variation of 5% and 9%, respectively. Total plasma homocysteine (tHcy) was measured by a high-performance liquid chromatography (HPLC) method with fluorescent detection, as previously described (11). High-sensitivity C-reactive protein (hs-CRP) was measured by a particle-enhanced nephelometric immunoassay with commercially available methods in a BNII Behring Nephelometer Analyzer (Dade Behring Inc.), as previously described (22).
The analysis of the MTHFR677C>T polymorphism was conducted by PCR followed by HinfI digestion (19, 23).
Statistical analyses
The distribution of continuous variables in groups are expressed as mean ± SD. Statistical analysis was conducted with log-transformed data for all skewed variables and geometric means (antilogarithms of the transformed means) are presented with 95% confidence intervals (CI). Statistical significance for differences in continuous variables was tested by Student unpaired t test or ANOVA variant analysis, with polynomial contrasts for linear trend when appropriate. Categorical variables were analyzed using a χ2 test, with χ2 for linear trend when appropriate. Adjustment for confounding variables was conducted by general linear model or logistic regression analysis. Interaction terms were estimated by means of general linear models. Receiver operating characteristic (ROC) curve analysis was conducted to identify the most efficient cutoff value of DNA methylation for cancer diagnosis as well as incident cancer occurrence during follow-up. The plasma folate concentrations corresponding to the 50° percentile in controls (12 nmol/L) were used as the threshold for either low (<12 nmol/L) or high folate (≥12 nmol/L). Statistical significance refers to a two-tailed analysis in which P value is less than 0.05.
Analysis of prevalent/historic cancer cases at baseline
The prevalence of cancer in this cohort was 9.2%, which is similar to that reported for the whole population in the same Italian geographic area. Cancer types were hematologic malignancies (20%), bladder cancer (19%), gastrointestinal cancers (13%), prostate (12%), breast (9%), kidney (7%), lung (6%), and larynx cancers (4%).
Cancer cases and controls as compared with other subjects within the study cohort showed a higher prevalence of coronary artery disease-affected subjects (88.4% vs. 69.8%; P < 0.001), slightly higher age (64.52 ± 10.89 vs. 59.74 ± 7.27; P < 0.001), prevalence of smokers (60% vs. 73%; P = 0.01), and subjects of male sex (83.7% vs. 75%; P = 0.039). No differences were instead detected in terms of plasma tHcy, folate, hs-CRP, and vitamin B12 concentrations (P > 0.2 for all the comparisons).
The main clinical and biochemical characteristics of patients with or without cancer history at baseline are described in Table 1. As shown, there were no significant differences between cancer cases and controls as it referred to age, sex, smoking habit, inflammatory marker hs-CRP, tHcy, and vitamin B12. Plasma folate concentrations were significantly lower in cancer subjects than in controls (9.86 nmol/L; 95% CI, 8.26–11.77 vs. 13.24 nmol/L; 95% CI, 11.9–14.72; P = 0.003). The frequency of homozygous mutants for the MTHFR677C>T polymorphism was significantly higher in cancer subjects as compared with controls (31.03% vs. 11.70%; P = 0.013). Moreover, cancer subjects who already had cancer at enrollment showed reduced global DNA methylation compared with controls who did not have cancer at enrollment (4.39%; 95% CI, 4.25–4.53 vs. 5.13%; 95% CI, 5.03–5.21, expressed as percentage mCyt/mCyt+Cyt; P < 0.0001; Table 1). By stratifying the study population according to quartiles of DNA methylation (defined on the basis of control's levels), subjects with cancer history were clearly more represented within the lowest quartile as compared with the others (P < 0.001 by χ2 test; Fig. 1). To determine a precise cutoff to differentiate cases from controls, a ROC curve analysis was conducted using data from the overall population, on the basis of which a threshold level of 4.74% for DNA methylation was chosen [area under curve (AUC) = 0.880 with 95% CI, 0.817–0.944; Fig. 2]. Subjects with DNA methylation lower than 4.74% showed a much increased prevalence of cancer (43 of 47) than those with higher (≥4.74%) DNA methylation levels (91.5% vs. 19%; P < 0.001 by χ2 test; OR, 45.9 with 95% CI, 14.3–147.6; Fig. 3). Such association persisted statistically significant even after adjustments for sex, age, smoking habit, serum concentrations of inflammatory marker hs-CRP as well as plasma folate, vitamin B12, and tHcy concentrations (OR, 35.9 with 95% CI, 8.0–160.5; Fig. 3).
In a gene–nutrient interaction model analysis, to better define the potential significance of the DNA methylation cutoff value, the combined effect of MTHFR677C>T genotype and plasma folate concentrations in determining DNA methylation levels and in relation with cancer history was explored (Fig. 4). No statistically significant interaction term was found (for DNA methylation P = 0.718; for cancer history P = 0.201). However, the data were indicative for an additive effect between MTHFR677C>T genotype and plasma folate concentrations in determining DNA methylation, with the subgroup of MTHFR677TT homozygous carrier associated with low plasma folate concentrations having the lowest DNA methylation levels (4.39% mCyt/mCt+Cyt for MTHFR677TT with low folate; Fig. 4A). The reduction in DNA methylation levels associated with MTHFR677T allele was significant only in those subjects with low plasma folate concentrations (P = 0.019 by ANOVA with polynomial contrast for linear trend), whereas among those with high plasma folate concentrations there was no statistically significant association (P = 0.181 by ANOVA with polynomial contrast for linear trend). Consistently, the subgroup of MTHFR677TT homozygous carrier associated with low plasma folate concentrations showed also the highest prevalence of subjects with cancer history (81.2% MTHFR677TT vs. 52.2% MTHFR677CT vs. 38.1% MTHFR677CC; P = 0.011 by χ2 for linear trend). The association between MTHFR677C>T genotype and cancer was significant only in subjects with low plasma folate concentrations (P = 0.011 by χ2 for linear trend) and not among those with high plasma folate concentrations (P = 0.761 by χ2 for linear trend). Considering MTHFR677CC subjects with high folate concentrations as reference group (OR = 1), only MTHFR677TT subjects with low folate concentrations showed a higher risk of cancer (OR, 7.04; 95% CI, 1.52–32.63; P = 0.013), whereas no significant association was observed for MTHFR677TT subjects with high folate (OR, 1.77, 95% CI, 0.53–5.89; P = 0.35; Fig. 4B).
Analysis of incident cancer cases during the follow-up
The main clinical and biochemical characteristics of patients with cancer during follow-up as compared with controls are described in Table 2. Controls and incident patients with cancer were age- and sex-matched and with similar percentage of subjects with smoking habit. As shown, DNA methylation at time of enrollment was lower in incident patients with cancer as compared with controls [4.47% (95% CI, 3.92–5.12) vs. 5.07% (95% CI, 4.95–5.18); P = 0.001]. Among those analyzed for DNA methylation, 10 subjects died during the follow-up period: 4 of them died of cancer and 6 of other causes, mainly of cardiovascular disease. Those who died of cancer had a lower global DNA methylation as compared with those who died of other causes [4.17% (95% CI, 3.48–4.96) vs. 4.89 (95% CI, 4.57–5.19); P = 0.015]. The survivors had overall a significantly higher methylation as compared with those who died of cancer [4.93% (95% CI, 4.79–5.01) vs. 4.17 (95% CI, 3.48–4.96); P = 0.004] but not to those who died of other causes [4.93% (95% CI, 4.79–5.01) vs. 4.89% (95% CI, 4.57–5.19); P = 0.79]. A further analysis was carried out, to determine a precise cutoff to differentiate subjects who did or did not develop cancer during follow-up, a ROC curve analysis was conducted, on the basis of which a threshold level of 4.69% for DNA methylation was chosen (AUC = 0.834 with 95% CI, 0.714–0.954). Subjects with DNA methylation lower than 4.69% showed a much increased occurrence of incident cancer than those with higher (≥4.69%) DNA methylation levels (66.7% vs. 5.3%; P < 0.001 by χ2 test; OR, 36.0 with 95% CI, 3.9–329.9). Such association persisted statistically significant even after adjustments for sex, age, smoking habit, serum concentrations of inflammatory marker hs-CRP as well as plasma folate, vitamin B12, and tHcy concentrations (OR, 43.6 with 95% CI, 2.7–708.4).
DNA methylation has been extensively studied as an epigenetic mechanism for carcinogenesis as well as a potential biomarker for cancer disease. However, decades of study could not clarify the mechanistic and clinical significance of DNA methylation due to its diverse biologic functions as well as its unique tissue specificity. In the present study, we enlightened the value of DNA methylation as a clinical index to screen patients affected by cancer or at risk to develop cancer disease. Interestingly, global DNA methylation status of cancer subjects was invariably decreased compared with control group subjects, indicating that cancer subjects have a systemically decreased global DNA methylation. Furthermore, we also observed that global DNA methylation in PBMCs at the enrollment was lower in subject who developed cancer during the 8-year follow-up period as compared with those who did not develop cancer during the same period.
Our observations are consistent with previous studies, which investigated the relationship between peripheral blood leukocytes DNA methylation and the risk of cancer (24). In a case–control study, leukocyte DNA hypomethylation was associated with increased risk for adenoma (Ptrend = 0.01) and a nonsignificantly increased risk for cancer (Ptrend = 0.08). In that study, colorectal cancer subjects also had significantly lower blood folate (16). In the Colorectal Neoplasia Screening With Colonoscopy in Asymptomatic Women at Regional Navy/Army Medical Centers (CONCeRN) Study subjects, women in the second (OR, 0.72; 95% CI, 0.34–1.52) and third tertiles (OR, 0.17; 95% CI, 0.06–0.49) had lower risk of colorectal adenoma, which is a precursor of colorectal cancer, compared with women in the lowest tertile of leukocyte genomic DNA methylation (Ptrend = 0.002). Several other studies in which the overall white blood cell genomic DNA methylation was measured as a marker of different cancer types including bladder (25–27), stomach (17), breast (28), and head and neck cancer (18), have found an elevated risk for cancer among those in the lower quantile of genomic DNA methylation compared with those in the highest quantile, regardless of the methods to measure global DNA methylation.
Owing to the LC/MS DNA methylation assay that can precisely measure DNA methylation status, it was possible to observe cutoff values, interestingly very similar in both prevalent and incident cancer study design (4.74% and 4.69% global DNA methylation, respectively), that clearly differentiate controls from cancer subjects by DNA methylation status, indicating that this values might be considered as a clinically valuable marker for cancer screening. Our study also indicates that a possible cause of conflict results from previous studies that determined the efficacy of global DNA methylation in PBMCs as a cancer biomarker might be the method used to measure DNA methylation, which does not always have adequate sensitivity and reproducibility.
Even though we found a significantly lowered genomic DNA methylation status in patients with cancer, it is not straightforward to explain why patients who have cancer originated from different types of organs have a decreased DNA methylation status in their PBMCs, especially because epigenetic patterns are usually considered to be highly tissue specific. Furthermore, PBMCs are normal cells that are expected to maintain normal DNA methylation status as compared with cancer cells, which instead tend to have decreased global DNA methylation. We, however, may speculate about the implication of several mechanisms by which cancer subjects have decreased global DNA methylation in PBMCs: (i) cancer developed from a certain organ may alter the whole body metabolism such as energy metabolism or one-carbon metabolism that mediates methyl transfer reactions even for maintenance of a stable DNA methylation status. The global metabolic unbalance as well as that of DNA methylation reaction in cancer may subsequently induce a reduction in global DNA methylation of PBMCs; (ii) circulating cancer cells or cancer products such as miRNAs or inflammatory mediators directly affect the PBMCs DNA methylation in blood; and (iii) the systemic condition that accelerates cancer development concurrently reduces DNA methylation in PBMCs.
The results of this study support the hypothesis that decreased global DNA methylation status rather indicates a systemic condition prone to cancer development instead of a direct cancer effect, because: (i) in our study, global DNA methylation in PBMCs was already decreased before developing cancer, and (ii) findings from this study show a combined effect between MTHFR677C>T genotype and plasma folate concentrations, both of which have been regarded as cancer risk factors, for DNA methylation levels and cancer risk at the same time: if associated with low plasma folate, the MTHFR677TT homozygous mutant genotype seems to be crucial in determining the lowest DNA methylation levels and the highest risk of cancer.
Because DNA methylation is a predictor for the development of cancer, it seems that lowered DNA methylation in PBMCs imply that this epigenetic feature collectively reflects the systemic condition that can favor the development of cancer. In this regard, it would be of high interest to follow-up the patients for a longer period and to enlarge the population sample set to be able to evaluate the drop in global methylation levels according to different types of cancer as well as to timing of cancer development. Further studies are warranted in this view.
Among the most interesting findings of the present study, there was also the observation of a decreased DNA methylation status related with lower folate status and higher frequency of MTHFR677TT genotype. Furthermore, MTHFR677TT variants further increased the risk only in those subjects with low folate status (OR for cancer of 7.042; 95% CI, 1.52–32.63; P = 0.013). These observations are consistent with previous reports describing that higher cancer risk associated to the presence of MTHFR677TT genotype only for those subjects with low folate status (29) but the link with reduced methyl availability due to lower plasma folate concentrations was previously only hypothesized (29), and this was confirmed by the present data in which a potential mechanism for this relationship is brought into play by the correlation with lower DNA methylation status.
In conclusion, the low global DNA methylation levels in PBMCs may be a predictor of cancer. The low global DNA methylation can also predict the development of cancer in the near future. Measurements of plasma folate concentrations and genotyping for MTHFR677C>T polymorphism may give an additional impact in subjects with low DNA methylation status. In the future, larger prospective clinical studies are certainly warranted. Whether differences in DNA methylation are related to disease status or outcomes as well as the understanding of precise correlation between PBMCs and specific cancer tissue DNA methylation also need to be determined.
Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the U.S. Department of Agriculture.
Authors' Contributions
Conception and design: S. Friso, S.-W. Choi
Development of methodology: S. Friso, P. Guarini, P. Pattini, S.-W. Choi
Acquisition of data (provided animals, acquired and managed patients, provided facilities, etc.): S. Friso, S. Udali, P. Guarini, C. Pellegrini, P. Pattini, S. Moruzzi, D. Girelli, F. Pizzolo, N. Martinelli, O. Olivieri, S.-W. Choi
Analysis and interpretation of data (e.g., statistical analysis, biostatistics, computational analysis): S. Friso, S. Udali, S. Moruzzi, F. Pizzolo, R. Corrocher, O. Olivieri, S.-W. Choi
Writing, review, and/or revision of the manuscript: S. Friso, S. Udali, P. Guarini, C. Pellegrini, S. Moruzzi, D. Girelli, F. Pizzolo, R. Corrocher, O. Olivieri, S.-W. Choi
Administrative, technical, or material support (i.e., reporting or organizing data, constructing databases): S. Friso, C. Pellegrini, P. Pattini, O. Olivieri
Study supervision: S. Friso, N. Martinelli, R. Corrocher, S.-W. Choi
Grant Support
This material is based on work supported by the U.S. Department of Agriculture, under agreement No. 51000–074-01S. This project has been supported in part by the NIH Grants R01 AG025834 (to S.-W. Choi) and in part by Cariverona Foundation, Italy (to S. Friso).
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
The authors thank Mrs. Maria Zoppi for her invaluable help for the secretariat work and Mr. Diego Minguzzi for his excellent technical assistance.
- Received July 22, 2012.
- Revision received November 29, 2012.
- Accepted December 11, 2012.
- ©2012 American Association for Cancer Research.


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It's true, I'm staying off the bike in the cold and won't go out in the snow or if it bit of ice might be around. But that doesn't mean you can't pull a Doug and get in some extra miles on me this winter.–Corrie
Every time it snows, the jokers at work ask if Ive got studded tires on my bike. Har har. Or if I remembered to put on the tire chains. Oh stop, now youre really killing me

subset: commoncrawl


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@TODAYshow @CarsonDaly if anyone wears the #MetsDress they would definitely be the #BestDressed at the #Oscars2015 pic.twitter.com/7hnczXvbZo
Unlike most of the other things surrounding the Mets organization, that dress is not the least bit disappointing. (Zing!) In fact, it got me thinking about other major fashion moments in baseball history. From the first baseball stockings to the batting helmet to top-of-the-line shades, attire has always served an important function on the diamond.
— HitchnerArt (@HitchnerArt) February 18, 2015
MLB can't hold a candle to the NBA in terms of fashion -- historically or recently -- but baseball has seen its share of Seventh Avenue moments. With that in mind, here are my five favorite instances of the garment industry intersecting with the game we love:
5. Dave Parker, repping the '70s
|Steeze (via cabinetbeer.com)
4. Ken Griffey, Jr., rocking the backwards hat
When Griffey participated in the 1993 Home Run Derby at Camden Yards, it was another example of the guy they called the Kid just acting like one of the kids. Griffey's backwards lid trumps other All-Star Game style choices like Jeter's baller cleats and Larry Walker's backwards helmet. It also beats out last year's "Fields of Fashion" promotion in that fashion hotbed known as Minneapolis.
3. Hawk Harrelson, pioneering the batting glove
Harrelson, who's now best-known for his obnoxious announcing, first wore batting gloves in 1963 to cover a golf blister. This moment was more of a functional, on-field event, but it warrants a mention here because batting gloves have since become a way to make a fashion statement.
2. Babe Ruth, killing it in fur
|Ruth in '31 (Photo via myauctions.com)
1. The White Sox, bulging out of their shorts
In August of 1976, the White Sox took the field for the first game of a doubleheader wearing Bermuda shorts, the brainchild of eccentric owner Bill Veeck.
|Ralph Garr and Minnie Minoso (Photo via karamaxjoe.webs.com)
The shirt in that photo almost looks like it was done using body paint. And those shorts could make an Olympic sprinter blush. That ensemble had actually debuted during a bizarre springtime fashion show, making this moment an appropriate topper to our list.
As for this season, I'm curious about what new fashion trends will permeate the game. What might we see this year? Will an ejected player or manager concoct a disguise akin to Bobby Valentine's? Will Matt Kemp take over for Derek Jeter as the game's best-dressed player? What ridiculous get-ups will Joe Maddon dream up in his first year with the Cubs? Will Justin Verlander again make news for his lack of clothing? Time will tell.
Oh, and there's one more fashion-in-baseball moment that we'd regret omitting:
Honorable Mention: Smalls, nerding it up
There is no written statement that could adequately describe this fashion statement:
|Via nbcsports.com
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Follow FranT on Twitter at @frantweet and follow Brian Kavanaugh at @btkav


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medicare.gov plan finder tutorial
The Medicare Gov Plan Finder could be a useful gizmo for work all the Medicare health plans out there in your space. It's straightforward to use, and therefore the info is up to this point. If you're examining your Medicare choices for the approaching year. As countless Americans do, the Medicare set up Finder could be a fantastic place to start out.
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medicare.gov plan finder instructions
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Gallery of How To Use Medicare Gov Plan Finder In 2018 Review
Tags: #medicare.gov plan finder not working #medicare.gov plan finder part d #medicare.gov plan finder program


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Adobe Bridge Select Fogra39
Problem: Syncronize all Adobe apps with a custom Color Profile. You cannot edit profiles in Bridge. For example, we wanted all Adobe apps to proof into FOGRA39 instead of Prepress2 Default FOGRA27.
Sololution: Create your profile in Photoshop (or any other app, Color Settings) and SAVE IT TO A FILE. After that, you can choose it in your Bridge CreativeSuite Color Profiles List.


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This week's "Crime of the Week" focuses on a Felony Assault which took place on the Westside of Columbus.
On Saturday, June 10, 2017, at approximately 3:30pm, a young mother was playing with her children, ages 1 and 2 years old, at Westgate Park, when her three year old broke another child's "sippy" cup. The young mother apologized to the other unidentified mother and offered to pay $10.00 for the cup. The unidentified mother became irate and refused the money, saying that it wasn't enough. The young mother again apologized and moved away from the other woman to avoid further confrontation. As the young mother was putting her 1-year old child into a swing, the other mother approached and hit her in the face. The two women briefly fought and then separated. Then an unidentified male, who is believed to be the husband or boyfriend of the irate mother, approached the young mother and, without saying a word, punched her in the face, knocking her unconscious. When the victim came to, she gathered up her two young children and drove to a nearby family member's house. From there she was taken to the hospital where it was discovered she suffered extensive injuries, including a broken jaw in two places, requiring surgery. Because of this assault, she now suffers permanent paralysis on the right side of her face. Not only did the victim suffer assault in front of her small children, she also lost her job because she was unable to work due to her injuries.
Crime Stoppers is offering a cash reward for any information leading to the arrest and/or indictment of the person(s) responsible for this crime. Anyone with information about this crime is asked to call Crime Stoppers at 614-461-TIPS (8477) or go to our website at www.stopcrime.org and e-mail your tip. You may also submit a tip by downloading our new free P3 Tips mobile app available on the iOS and Android platforms. We are no longer taking tips via text message.
All tips to Crime Stoppers are anonymous. Crime Stoppers does not use Caller ID or record telephone conversations. A special coding system protects the identity of the caller. Crime Stoppers also takes calls from persons with information about any felony. Information leading to the arrest and/or indictment of a felony suspect could qualify the caller for a reward as determined by the Crime Stoppers Board of Directors. For more information on Central Ohio Crime Stoppers, visit our website at www.stopcrime.org.
Crime Stoppers is a non-profit 501(c) (3) organization. Reward money comes from private individuals, businesses, and foundations that see Crime Stoppers as an integral tool in the community's fight against crime. Tax-deductible donations can be sent to Central Ohio Crime Stopper's, Inc., and P.O. BOX 16038, COLUMBUS, OH 43216-6038.
Watch for the depiction of each "Crime of the Week" during newscasts on WCMH NBC 4, Sunday morning 7a.m., 9 a.m. and at 6 p.m., as well as Monday 12 Noon. Also watch for the depiction to be aired on WBNS 10TV, WSYX ABC 6, WTTE FOX 28, and featured in The Columbus Dispatch every Monday.


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SweetieBelle\'s Sister by EmoshyVinylWatch
©2014-2018 EmoshyVinyl
As you can tell, I still need to work on drawing characters, as well as her having Sweetie Belle's design.
I'm not very good at naming OCs so I rather get help from the audience.
Her name has been decided to be Moonshine, by Ditzy-Derp-Draws. I accepted this due to her having the color of Luna's original coat.
Keep in mind that her BF will be with her soon.
Pretty Good considering the color of her coat and mane. So right now your suggestion will be one of those that I'm thinking of, but let's see what a few others say.
Srry but maybe if you add something more into it, it would be good bluebell is too obvious if you know what I mean.
Moon Shine or Moon Ribbons?


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Monday, November 24, 2008
Children's Museum
6 comments:
- patsy said...
I love that museum.
One year beth gave us passes- one of my all time favorite presents.
so glad you are taking cole!!
- November 24, 2008 at 8:19 AM
- Johnna said...
I love his confidence! We will have to go next time we are over.
Love you....mom
- November 24, 2008 at 8:23 AM
- Megan said...
How fun! I love the children's museum!
- November 24, 2008 at 8:31 AM
- caitlin said...
That looks like so much fun! I want to go now! I guess we will just have to come back and visit you again ;)
- November 24, 2008 at 9:31 AM
- Dana said...
That really looks so fun! I know my kids would love it. BTW he looks so cute in his orange fleece!
- November 24, 2008 at 9:33 AM
- Haley said...
Yay! You posted! I've been faithfully checking every day and am so glad to come and see such a fun post...Cole is adorable (I love his orange fleece). I agree the three chairs do look fun...I have three little chairs in my house that range from largish to tiny and I always line them up by each other and wonder if anyone will notice the Goldilocks reference. :-)!
- November 24, 2008 at 11:42 AM


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Oh my little Harper I think I love you! This little guy is way beyond his years (or weeks I guess). A serious little fellow who you can just see has important stuff to say as he stares so intently into your eyes. SO cute it hurts! I have four weeks left til I can meet my little guy and doing Harper's photos got me more than a little impatient.:) Congratulations Cole and Telina you are both doing a great job at this parenting thing.
Styling Overalls, the Grown Up Version
16 hours ago


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...is a precious thing. And here is one that needs some help.
At the weekend, while at Maryvale, I met a lady who has been accepted as a postulant in the Carmelites, and all was going well...but she has a problem. She owns a small house on the outskirts of Birmingham and has been unable to sell it. She is not allowed, under Church law, to enter a religious order until she has sorted out obligations of this sort. The house is a modest one, and she needs to sell it in order to pay off the mortgage and be free to follow her call.
Can you help? The convent has released her until the sale goes through. She is working as a supply teacher...and is desperate for help in getting this small house sold! Any offers of help/advice would be appreciated. Send a COMMENT to this Blog marking it "Not for publication" and INCLUDING IN IT YOUR EMAIL ADDRESS so that I can contact you.
Wednesday, June 12, 2013
A vocation to the Carmelites...
Posted by Joanna Bogle at 10:52 pm
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As I paid my rent today, I wished Tomasita, "Happy October!!" I can not believe how fast the year has gone. I guess that is a sign of getting older or having a busier schedule.
This morning Juan called me as he was still trying to get to Chichi. They were working in the road, trying to get a lane open, but he was told it would be about 3 hours. Manuel and a few others had started out with Juan but when they knew they had gone as far as they could, they finished walking. Gaspar had walked from Xepocol to Clinica Caris.
Juan finally made it to Chichi and then on to the clinic. I stayed in Chichi, printing photos for some of our patients.
I called Josefina to see if they were ok but they were still waiting for Manuel to make it to Santa Cruz. She called me about 2 hours later and said they had arrived in Mactzul 5 but the roads had been very bad.
We are praying for some dry weather. It did rain some this afternoon but not like the last four days so maybe we will hit a dry spell.
Friday, October 1, 2010
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My first layout is of Nora and a sweet moment of her with her daddy at church one morning.
I like to add a little vellum under my photos for a little texture and softness. The calendar cards are great for everyday moments.
I removed the center of the letters and added patterned paper behind.
For my second layout, I decided to create one with a fall theme and pulled out my Cricut and the Straight from the Nest cartridge to help me cut out some leaves. I also used some leaf punches. I kept the colors of this layout to mostly brown, blue, cream and orange to match the girls' outfits as they played in the leaves.
I cut a variety of leaves using the punches and Cricut and then scattered them around the page.
For this title, I misted the "happy" card with Tiger Lily Glimmer Mist and stapled some twine to the top.
The larger leaf is actually punched from wood veneer and then backed with patterned paper.
While I was at it with the Hopscotch collection, I created a card.
I pulled out the pinks and blues and used the leftover punched leaf from the layout with some layered chipboard and buttons.
Thanks for stopping by today! I'll share my projects with the "Home for Christmas" collection soon!
I've been pretty sick the past few days and finally headed to the doctor this afternoon for some meds. Here's hoping I'll be feeling like myself soon! :)
Have a great weekend! :)


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Shameless - Complete Series 1-11 DVD|
For almost a decade Paul Abbott's BAFTA award winning series Shameless earned droves of adoring fans with its blisteringly funny and jaw dropping portrayal of the UK underclass. Now in this complete collection is a chance to relive the crime chaos and debauchery of Manchester's Chatsworth Estate! Follow anti-hero Frank Gallagher staggering from The Jockey to adventures in France a mental institute and prison fuelled of course by his trademark round of a pint and two Es. The Gallagher family - Fiona Lip Ian Carl Debbie and Liam - pick up the pieces left by their absent mother and erratic father with the assistance of Fiona's partner Steve; consequently they are often caught on the wrong side of the law struggling with squalor sexual misdemeanours and drug smuggling boyfriends. Watch the rise and rise of the Maguire Empire as their drug dealing exploits led by the proud yet vicious partnership of Paddy and Mimi make their family a fearsome force not to be messed with. In a life constantly plunged into the depths of extreme crime witness their children Mandy Jamie Shane and Micky balance complicated problems of their own with the upkeep of strict family values. And of course no trip to The Chatsworth would be complete without checking into The Jockey for a proper party! Enjoy all eleven series including the Christmas and New Year specials here. scatter!from£49.99 | RRP:
* Excludes Voucher Code Discount
- 02 September 2013
- David Threlfall
- Channel 4 DVD
- 6471 minutes
Please note this is a region 2 DVD and will require a region 2 or region free DVD player in order to play SHAMELESS follows the story of the Gallagher family a hapless working class family living in a Manchester council estate Fiona the eldest of the six Gallagher children is lumped with the responsibility of taking care of her younger siblings after their mother Monica left and Frank fell into alcoholismA Age Rating 18
Every episode from all eleven series of the offbeat and often outrageous Channel 4 family drama following the lives and loves of the anarchic Gallagher family who live on a rough council estate in Manchester. Mum Gallagher went AWOL years ago, leaving eldest daughter Fiona (Anne-Marie Duff) to look after her five younger siblings while dad Frank (David Threlfall) hit the bottle. The Gallaghers elect to improve their status upon the estate via an allegiance with local gangsters the Maguires, who, if anything, challenge the myth of a conventional family even more successfully than Frank and his kin...
More Titles Starring David Threlfall
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Governor Doyle signs bill to regulate dog breeders
MADISON, Wis. (AP) -- Gov. Jim Doyle has signed a bill designed to eliminate puppy mills where dogs live in abusive and neglectful conditions.
The law will require dog breeders who sell more than 25 dogs annually to get a license through the state.
Breeders will have to meet standards of care, such as providing each dog with enough food, shelter and opportunity for exercise.
The state will investigate the breeder's background before issuing a license and can suspend or revoke it for violations.
Animal rights activists have been pushing for regulations in Wisconsin for years, saying the state's hands-off approach has made it a magnet for large-scale puppy mills
xoxo (Much thanks to Gov. Doyle!)


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Posted on 36 days agoSarva Management Solution
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As a pediatric surgeon, Dr. Saad Saad has been able to do numerous of procedures to the patients of different categories. The methods used for pediatric surgery were not pleasing to Dr. saad, and he had intentions of making them to operate better. The reason for his need to improve the technology used in carrying out the pediatric procedures was attributed by the pain and risks the patients were exposed to in the community. He is highly experienced because he has a vast experience serving as a pediatric surgeon. In the United States he served in four Medical Missions and Jerusalem he was allocated to eight Medical Missions where he offered surgeries to children from poor communities.
One of the inventions of Dr. Saad Saad was to improve the operations of catheters. Catheters have lots of functions but the major one they are inserted into the body of the patient for smooth performance of surgery operations. Catheters have different uses depending on the type of catheter used. They can be used to access surgical instruments easily, draining gases amongst many other functions. Dr. Saad Saad identifies the risk of using the catheters by surgeons when determining their positions in the body. X-ray could be carried out, and the position could be detected. The radiations emitted by the scanning from x-rays were a great threat to the life of the patient.
For this reason, Dr. Saad came up with the idea of improving the effectiveness of catheter without interfering with the life of the patients without scanning. With this, he invented the catheter with integral electromagnetic location identification device. This made the surgeons to know the exact position of the catheter without scanning the patients. The device was not complicated, and other surgeons could use comfortably and carry out their surgical procedures to patients.
An endoscope was another method that Dr. Saad Saad improved its performance. This is an instrument used by surgeons to examine the inside organs of the patients. They are fitted with an optical device for an unobstructed view. The use of endoscope was effective; however, the problem was that the optical lens would be obstructed with the fluid produced in the body and doctor would have to remove the endoscope and wipe the liquid and start the process again.
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Besides, Dr. Saad offers his services to lots of hospitals in New Jersey where he has over 21 years in the industry. He received his degree from Cairo University. It is imperative to understand that the contributions made in improving the surgery methods and procedures by Dr. Saad Saad were crucial in enhancing the safety of patients. Learn more: https://medium.com/@dr1saadsaad


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Response Letters to the editor for "China Terrorizes Tibet" (editorial, March 18)in New York Times:
Why isn't the International Olympic Committee making clear that building stadiums and cleaning up the air — not maltreating people — are the way to prepare for the Olympics?
The Games in China have become a pretext for the arrest and detention of democracy advocates; the intimidation of human rights lawyers; the shunting away from the capital of petitioners from the rural areas; the cracking down on Falun Gong followers; the forcible return of North Korean refugees; and now the terrorizing of Tibet.
While it is true that the Olympics also offer an opportunity to those who would embarrass China, its politicization of an international sports event should be deemed unacceptable.
No government should be allowed to make repression of its population part of its preparations for the Olympics.
Roberta Cohen
Washington, March 18, 2008
To the Editor:
Re "Tibetans in India Enraged by Details of Crackdown" (news article, March 18):
The physical and cultural violence that the Chinese government has directed toward the Tibetan people for the past half century is threatening to undermine the nonviolent and compassionate traditions that have been such a vital part of Tibetan Buddhism, and also a rare gift to a world that is so lacking in its practice of these qualities.
But as China retains its unyielding attitude and raises the level of persecution, it pushes some of the young people of Tibet toward a more radical position that could eventually include greater violence. The Dalai Lama's nonviolent "middle way" offered hope for a workable solution, but that hope seems to be fading.
It is hard to imagine a light at the end of the tunnel for the Tibetan people without a much stronger response from the rest of the world.
Tibet can seem like a remote place, but freedom from fear, and freedom to practice one's religion, are fundamental human rights that know no borders or geographical distances.
John N. Corbin
Pleasantville, N.Y., March 18, 2008
To the Editor:
Re "Tibetans Clash With Chinese Police in Second City" (news article, March 16):
According to the president of the International Olympic Committee, Jacques Rogge, boycotting the Olympics would be "penalizing innocent athletes." Really? What about innocent Tibetans?
I've lived in Lhasa, Tibet, and mainland China, and I know what life is like under a brutally repressive regime.
I remember a teenager who spent three years in a Lhasa prison because, in an angry impulse, he posted a letter denouncing the Communist Party. And a teacher who was arrested for telling his pupils traditional Tibetan stories. I remember constant fear and anxiety.
Politicians claim that economic development is pushing China toward greater freedom and justice. As far as I know, Tibetans have not benefited from China's economic boom; the Chinese justice system serves the powerful and rich; corruption is rampant, and whoever speaks up is silenced.
Yes, some middle-class Chinese now have the illusion of freedom because they wear Nike sneakers and chat on China's strictly censored Internet.
The Beijing Olympics aren't an international celebration of brotherhood and athletics; they are the Communist Party thumbing its nose at anyone who cares about human rights.
If we don't speak up, we are cowards and accomplices.
Judith Hertog
Hanover, N.H., March 18, 2008


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Sunday, April 29, 2012
Salut la famille Thomas!
Things are still cold and super wet here in Lille. And once again I went a week without purchasing a rain coat. Oops. But today it is fairly sunny and a little warmer! Booya!
You asked what Bisou means. Bisou means kiss in French haha. I can't believe that I haven't told you guys about bisou's yet! Everyone in France bise's people. That means when they say hello instead of a hug or handshake like in the states they kiss each others cheeks like you've prolly seen in a movie or something. It's really funny. Everyone does it but we aren't allowed to. Which makes some people mad. Because it's like if someone said hello to you in the states and you didn't say anything back. Oh well. I have had a lot of people try to bisou me. Haha!
So this last week was a little rough. I've hit a bit of a bump with my comp. I'm not sure what it is but there's a tension there sometimes and other times life is normal. Oh well. He's kind of a punk sometimes... haha. But, I think it was just hard because the work is frustrating at times. We got fruged several times this week. Which is never fun. Our rdv (rendezvous) with Phillipe the talker was moved all over and is now set for tomorrow. The other rdv. with Phillipe2 was bad. He brought a friend who we now realize was most likely a TJ (Jehovah witness). He bible bashed with us and we had a 2 hour rdv with them. Phillipe is actually interested I think. But the other guy was just trying to tear us apart. He was either a TJ or a priest. That will be the 3rd priest that I have met that was the biggest jerk I've ever met. It's ridiculous that a 50 year old man feels like he needs to tear down 20 year olds. The funny part is that we destroyed him. And we don't even speak French. Silly guy, trying to mess with us. It ticked me off so bad. But hopefully our next rdv with phillie2 will not be the same. Our rdv with Lima was cancelled and she is busy this next week too. I know she needs the gospel and that's why all of this stuff is happening. Antoine couldn't meet either. He is the one with the dreads. But the other elders in V D'asq had a baptism and we got our Ami Martiul from the ivory coast to come to it! It was the best baptism that I have been to. He liked it too. So hopefully that helps him. And Lassy texted us this week apologizing a ton for not being able to meet with us. He has been busy with school and exams but he promised he wanted to meet when that was done. So grateful for the blessings that we receive in the midst of trials. We always receive blessings. But sometimes they come in different ways.
This last week I went on exchanges with the elders from Dunkerque. That is about as north as you can get in our area. It is a little fishing town that when the weather is clear you can see England. It was really cool there. I have missed the beach so much! It was really cool to see another city too. I spent two nights there and got to see the town a bit. The first night it was pouring rain but we went porting still. We prolly went through 40 doors with half being slammed in our face and none of them wanting to listen. Oh yeah! So fun. But then we decided to knock a couple more before we left and we ran into this one lady who was pretty rude. She told us that religion caused all of the bad in the world and that she was too angry to have religion in her life. But I kept pushing her and testifying of the things I knew and of the Book of Mormon. Then, something amazing happened. She literally had a change of heart right in front of our eyes. She broke down crying and said she knew she was lost and was too prideful to admit it. She took the book and said that she really would read it and knew that she needed it in her life. That was so cool. Hopefully all goes well with her there!
This last Wednesday we had Zone Training and interviews with President Posnanski. It was super awesome! We had a training by the Zone Leaders and then by President. Then we all had our interviews with him. So we just had to hang around the church waiting for our turn. During the training with President he called on me to share an experience that I had written him about. We write a letter to him each Pday through email where we can say whatever. I shared an experience we had: we didn't know where to go contacting at the time and so we prayed to know where to go. After we prayed I suggested an area and we went there and met a cool guy and got his number. While I was explaining my experience with all of the missionaries in French I got to the part where we got his number. And in French it is just Numero de telephone. But there is another way that you can say phone number in slang. It is just "06" or "zero six in french. And I have never said it out loud before but for some reason that just came out. Haha! And everyone thought it was super funny and so did President. He was dying laughing and then he was like "Elder Thomas" vous parlez comme vous etes de le "93"!" The 93 or neuf trois is the area in Paris that is the super ghetto (haha) where the bad gangs are. Basically he said Oh Elder Thomas you speak like you are from the ghetto! Hahahaha. It was super funny.
He joked with me about it the rest of the day. The interview with him was super good. First thing he said when I got in his office was that I looked really good and thinner than before. That,made me feel super good. haha! We talked and he said he had heard a lot of good things about me and thinks I'm a great missionary and he also said how excellent my French was! So grateful for that! Haha.
Also, this last week we did something monumental. I had McDonalds for my first time in France... I prolly already told you about it huh? But they have an item called "Le Mcbaguette" hahahaha. Super funny. It is a cheeseburger on a baguette. It wasn't very good haha. I also sent home a package on Saturday. So look out for it! I was able to watch the videos you sent me last week too. They were so great! Hilarious.
France is starting to get crazy too because it is election time. Yesterday was the vote to narrow down the candidates to two. It is now Nicholas Sarchozy and Francois Hollande. The funny thing is that before, in the top ten candidates running there was a woman running and she is communist. That means she was popular enough to have a legit chance of winning. If that doesn't tell you how crazy France is then I don't know what can. We have two more weeks of this transfer. This week,and then one more. We transfer on the 8th or something. I really am hoping to stay in Lille for another transfer. I really think that I will too. But I will definitely have a new comp. One of is going. Also, my french has gotten a ton better this last week! I am so thankful for the ability that I have to speak and understand right now. I have full responsibility of the cell phone right now too. So, making and taking calls in French has helped a ton. You asked about the water here. Haha, the water is good. Only a couple dead bugs. We have enough food too. And I'm feeling good. Not sure about the enough sleep part but I'm good haha. Thanks :)
I love you guys and miss you so much! Maybe I will get to talk to you a little bit later in the day. Hope you guys have a great week! It sounds like you all are doing so well! Its awesome how blessed we are. I love you guys so much! Have fun and remember to pray :) Our Heavenly father is always there and loves us so much.
Love Taylor
Saturday, April 14, 2012
Good morning! 4-9-12
Easter was pretty good. Different than normal though. We went to church. We were supposed to have an amis there but he didn't show up. Oh well. After church we went home and were starving because it was fast Sunday haha. Here we start our fast on Saturday after lunch and then eat after church. We had a burrito fete! haha. That just means we ate burritos. Kind of wierd on Easter. Then we had a rendezvous with a Chinese student here. He was a referral from another area so we had never met him. We ended up standing at the metro station for an hour because he went to the wrong stop. We had a great lesson with him though. His name is Peng Fei. He is 24 years old and already has a Masters and is almost done with his second! Crazy smart. Then we came back home and set up a big couch with our mattresses in our room haha. And we watched the movie 17 miracles. It is so good. You need to go out and get it and watch it soon!
Hopefully we can find something to do today haha. All week we have been planning to go bowling. But today is a holiday. So there is nobody in the streets and everything is basically closed. We can't even do our shopping today. France is crazy about holidays and vacations. But I'm sure we will find something to do.
This morning we had a lesson with a man from Africa. It went really well. He already has faith. But now he said he will find out if the Book of Mormon is right. I finished the BofM again this last week! It is so amazing. I was also reading in the New Testament. I found a really cool set of scriptures that I wrote down and hung on my wall. I think it is John 14:12-21. I hope that's right. Anyway, I am doing well as always. France is so awesome. I can't let myself forget where I am! Whenever the work gets tough, which is a lot, we take a break and get some yummy food or just go into a cool store or take some pictures. It is so cool. I have no doubt in my mind about this gospel. It is really the truth. If I didn't know for 100 percent that it was true I wouldn't sacrifice so much for it. Everyone needs it in their lives.
I love you guys so much! I love the package and letters. Thank you again! I think about you guys all of the time. And I started writing down a list of things I want to do together when I get home. Love you and miss you! Talk to you soon and maybe later today since France looks dead today. Haha! Love you!
Elder Thomas
Friday, April 13, 2012
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Thursday, February 3, 2011
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Fremet Arms Manufacturing
Fremet last edited by Fremet
GE Headquarters in Rhodenheim
TRONDHEIM- Today, the Fremetian government announced that it would begin to expand its supply chain. The MoD gave the new supply contract to General Electric, and GE said in a statement today that they will be able to begin to fill orders by the end of the month. GE will be primarily offering aircraft from its subsidiary, GE Aviation. GE is the largest arms manufacturing company in the Federation of Fremet, and it will supply the FAF with over 90% of its aircraft and equipment. GE is expected to become Fremet's primary supplier of all aerospace goods.
((OOC: All of Fremet's Arms manufacturing News/Data will be posted to this thread henceforth; Posts are not IC Secret unless indicated otherwise))
Fremet last edited by Fremet
Unmanned Aerial Vehicles
Elbit Systems Ltd. is a Fremet-based international defense electronics company focused on the construction and development of unmanned areal vehicles for the military and other government agency. They also specialise in cybersecurity, and is a major contractor of the Fremetian government.
Origin Type Version
Status Estimated Production Date Amount Elbit Hermes 900 Fremet
MALE Hermes 900 "Kochav" In Development TBA 1 (Prototype) Elbit Hermes 450 Fremet Tactical UAV Hermes 450S "Zik" In Development TBA 2 (Prototypes
The Fremet Aerospace Institute is the one of the nation's premier aerospace developer and manufacturer. Historically, the company focused on civilian aircraft, but FAI has recently changed their focus to Unmanned Areal Vehicles.
Origin Type Version
Status Estimated Production Date Amount IAI Eitan Fremet
MALE Heron-TP "Eitan" In Development TBA 6 (Prototypes) IAI Heron Fremet MALE Heron-1 "Shoval" In Development TBA 3 (Prototypes)


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Westlake Man Terrifies Children with Break-In Hoax
Westlake Police report that a 46 year old Pineview Drive father put his 14 and 16 year old sons to the test on April 14 at 4:05 p.m. by staging a break in at their home to see if his children would obey his demands to not let strangers in the house.
At the dad's instigation, say Police, a 45 year old friend from Cleveland Hts. went to the front door and asked to be let in. The motive was to see if the boys followed a standing paternal order not to admit anyone except known relatives.
The younger son did let the friend in, who then acted the part of a recently released ex-con who was owed money by the father and made physical threats.
The scenario frightened the boys, who barricaded themselves in a bedroom, jumped out a second floor window onto the garage roof and then landed on the ground (precariously close to a sidewalk). The elder son suffered a minor scrape while exiting the home and then called 911 from a neighbor's house.
Officers responded code 3 to the home, only to find that it was all a charade.
The friend, in contact with Dad by phone all the while, wanted to stop the role play as things had gone too far. Dad insisted that it play out, say Police. He also refused to acknowledge the emotional upset he had caused, instead referring to his son's actions as an "epic fail".
Both boys were commended by the responding officers for securing themselves from the threat and making good their escape. The City Prosecutor will consider Child Endangering charges against both adults.
Life in the Fast Lane
I-90 was the place to be for impaired driving on April 11. That morning, a 21 year old Bay Village man went off the road eastbound and mowed down an ODOT sign near Crocker Rd. He had some reefer and pot paraphernalia with him. He tested .170 by breath; final score OVI, BAC, POM, Drug Para.
In the evening, a 29 year-old Westlake woman hit another car (with 3 occupants) while westbound near Cahoon Rd. A 52-year old Avon woman passenger from the other car suffered at least a concussion and was transported to St. John Medical Center by WFD. The other passenger and driver were not hurt. The impaired driver was arrested for OVI, BAC (.173 by breath), Agg. Vehicular Assault, Speed, and Improper Lane Usage.
Dept. of Swindlers & Thieves
The owner of a Center Ridge Rd. business was swindled out of $3000 by a caller who demanded that sum in gift cards or the electric service would be shut off. After transmitting the money, the victim had doubts and found out that the caller was a phony. The loss occurred on April 11.
A Northwood Ln. woman replied to a phony PayPal email, leading to a number of charges being made on the associated credit card account. No amounts were specified; she reported the ID theft on April 13.
A Lincoln Rd. man received letters advising him that his credit card application hand been denied and that his $25,000 loan application had been received; he had sought neither. The ID theft was reported on April 13 and may be related to a data breach at RITA.
A Columbia Rd. man's credit card was cloned and used to charge $581 worth of items at a North Olmsted store on March 7. He discovered the theft the next day and reported it.
A Northglen Dr. man found that his credit card was cloned and used in Ottawa Co. to make a $187 purchase. Two other attempts were declined at unknown locations; all took place on or about March 4. He reported the incidents on March 8.
Student Seriously Injured
A fight at Westlake High School on the afternoon of 4-12-16 between a 17 year old junior and an 18 year old sophomore resulted in the younger student's being hospitalized with very serious head injuries, report Westlake Police.
The fight took place in a men's washroom around 12:54PM. The younger student was found by staff and the WPD School Resource Officer and appeared lethargic; he was initially seen by the school nurse.
He was subsequently transported by family to Fairview Gen. and later airlifted to Metro Health.
The suspect, Deandrew SMITH of Westlake, turned himself in on 4-13-16 on a charge of Felonious Assault. His bond was set at $5000 and a no-contact order was issued. He posted bond that date and wasreleased; his next hearing is 4-19-16 in the Rocky River Municipal Court.
The case will be submitted to the Grand Jury for review.
Bad Behavior
A 35 year old Arizona man staying with his mom on Cedarwood Dr. got liquored up and threw patio furniture and other items off her balcony on March 8. He was arrested for DCI and also had warrants from Westlake and Bay Village PDs.
An intoxicated 44yoa man was sent on his way from a Detroit Rd. woman's apartment on March 10 at 6:51PM; he went to another friend's apartment. 90 minutes later he was back, pounding on her patio door. He was arrested for DCI.
When one truck driver asked another to move his rig at a First St. business on April 13, the second man (61yoa Westlaker) punched the first (58yoa from Euclid), breaking his eyeglasses and receiving a cut on his nose. The older man left, then came to the police station, where he was arrested for Assault.
An intoxicated 51yoa Westlake man's invitation to go to a bar was not well received by a female motorist as she pulled into her Detroit Rd. parking lot on April 14. When confronted by officers, he threw his pot pipe away. He was arrested for DCI, Drug Paraphernalia, and Attempted Tampering with Evidence.
'Good Neighbor' Hoax
A 'Good Neighbor' hoax surfaced in Bay Village on April 11 at 1137 hours when a Juneway resident reported that on April 9, a male came to his house and claimed he had just purchased the home across the street.
The visitor claimed he needed $22.00 to have his vehicle repaired. The homeowner gave the visitor $30.00 with the understanding that it would be repaid.
After not hearing from the visitor for several days, or seeing any activity at house, the homeowner decided he had been scammed. He described the visitor as a W/M, 40-45 yoa, 5'10", 175 lbs. with brown hair (receding hair line) and a beard. He was wearing dark rimmed glasses and driving a 2005-2007 Oldsmobile Alero. If anyone has had a similar encounter please contact BVPD at 440-871-1234.
Looking for Help
On 04/12/2016, at 0052 hrs, a resident in the 26000 block of Lake Rd. called BVPD to report she believed someone had knocked on her door, and the person now walking down the street. Responding officer located an illegally parked car on Parkside, and shortly thereafter were flagged down by a female walking down Lake Forest. The female indicated that her car had broken down, and she was knocking on doors looking for help. The officers suspected the female was intoxicated. Field sobriety tests were administered, and as a result the female was arrested for Disorderly Conduct-Intoxicated. She will face charges at RRMC.
Mystery Bell
A huge sigh of relief was heard throughout Bay Village after the Cahoon Family Bell at Rose Hill Museum was thought to be lost last weekend, but ended up accounted for. "The Cahoon bell has been found," says the Bay Village Historical Society after the bell was noticed to be missing from its post on Sunday. "The fine gentlemen at the Service Department removed it to replace the post, which was beginning to show signs of rot. A huge sigh of relief, and an even bigger thanks, to our city's Service Department."
Uber Trouble
On 04/23/2016, at 0334 hrs, a BVPD officer stopped a female who was walking on Lake Rd. at Fordham. After speaking with the 22 yoa female the officer suspected she was intoxicated. She admitted that she was, and that she had been in an Uber vehicle when the driver suddenly dropped her off on Lake Rd. away from her house. She indicated that she had a friend on the way to pick her up. When her ride arrived on scene police suspected that he had been drinking. Field sobriety tests were administered, and as a result the 26 yoa driver was arrested for OVI. The Bay Village resident will face charges at RRMC. The female made other arrangements for a ride home.
New 'No Turn on Red' Signs in Bay
Bay Village has erected new No Turn on Red signs at various intersections within the City. The new signs prohibit turning right on a red light at the noted intersections during school days from 7a-9a and from 2p-4p. Please take note of these new signs and help to insure the safety of students as they go to and from school.
Knife Threats
Police responded to the Swinging Door Lounge after receiving a 911 call of a male in the parking lot threatening patrons with a knife on April 13.. The first arriving officer located the subject in an alley and called out to him. The male responded and reached into his coat and pulled out a knife that was still folded shut. He was ordered to the ground, initially refusing, but complied after the officer drew his Taser. He was detained while officers spoke with employees and patrons. It was found that he was cut off from any alcohol due to "odd" behavior and then became belligerent, yelling profanities, shoving a female employee, and then threatening people after pulling out his knife. He was ultimately arrested for Assault, Aggravated Menacing and Disorderly Conduct: Intoxication. He was released on bond late morning of the next day pending his appearance in Rocky River Municipal Court.
A Balmoral Way home was burgled by breaking a window on April 15. Cash and jewelry were stolen from a safe that was forced open.
An 18yoa Elyria woman stole $40 worth of property from a Detroit Rd. store on April 15. She was caught by store staff and arrested for Petty Theft.
Two Dover Elem. School teachers had cash stolen from their purses on April 15. The purses were in the respective teacher's classrooms.
An intoxicated 30yoa Mexican national male caused a disturbance at a Columbia Rd. restaurant on April 17 and was kicked out by staff. Officers found him nearby and arrested him for DCI. He was released to CBP when he sobered up.
A Chadwick Ct. boy's scooter was taken from Dover Elem. School on April 18. It was located later that day at the High School.
A 52yoa Bradley Rd. man hit his 44yoa wife in the face on April 19 after they argued over housekeeping. He was arrested for DV.
The wires on a Painesville man's commercial mower were cut on April 18 while it was unattended at a Crocker Rd. jobsite. He suspects a competitor in the landscaping business.
$283 worth of merchandise was stolen from a Detroit Rd. store on April 21. The suspects are two black females in their 20s-30s. One female wore a black/gray raincoat, black pants, and eyeglasses. The other had on a maroon or pink coat and black pants.
A Smith Ave. woman was contacted by the issuing bank about odd transactions on her grocery store credit card. Since she had never applied for such a card, she reported that matter to WPD on April 21. Someone in MI made $1000 in charges on the same day the card was issued.
A 53yoa Center Ridge Rd. woman pushed her 52yoa female household member down on April 21, causing a knee injury. The elder female was arrested for DV.


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126 Kings Cross Road
, London,
1 reviews
Islington Barnsbury
Every little corner of London has a popular Indian restaurant that the locals love, and the Taste of Asia located on the busy Kings Cross Road in WC1X, is just that. Friendly, affordable and
efficient, this modern Indian dining room is busy with both dine-in and takeaway customers who keep coming back for the restaurant's classic curries. Perfect for after-work meals, mid-week meetings
and affordable family nights out, Taste of Asia serves up generous portions that will fill everyone to the brim. Close to Kings Cross and St Pancras stations, the Taste of Asia is always busy with
local office workers, commuters and curry lovers.
Best Female Chefs Series
In the Year of the Woman, SquareMeal is running a series of interviews with top female chefs. Read here to discover the sense of achievement Monica Galetti feels about owning her first restaurant, what it's like working with her husband, and the different ways in which Masterchef has changed her life.
Rate & Review
From the a la carte menu based on each person having 2 course meal (a starter and main course per person). Please note there will be a supplement fee of £3 for all seafood dishes. The nearest station to this restaurant is Kings Cross (8 minute walk).
From: 08 May 2018
To: 08 August 2018
Max: 8
Includes Vat, excludes service
Click here for Links & Logos
Kings Cross Thameslink Station 87m
King's Cross Tube Station 457m
126 Kings Cross Road
, London
Islington Barnsbury
Courtyard Theatre 417m
Regent Square Park & Garden 524m
020 7713 0099
Visit Taste of Asia
Food & Drink:
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Food & Drink: 2.0
Service: 2.0
Atmosphere: 2.0
Value: 2.0
We chose this restaurant for a pre theatre meal after reading reviews about it. First impressions were ok but it then started to go downhill. I ordered and king prawn dansak which is my favourite dish by far. Anyone that likes a dansak will know that it is a dish that is hot, sweet and sour. Well it was a little sour, but by no means was it hot and there was NO element of sweetness at all so needless to say i was not impressed. My wife had a chicken tikka korma which again was not up to the mark and the naan bread she ordered was swimming in fat where it seemed to have been fried. The other thing that really put me off was that if i had a query/question regarding anything the man at the front of house would say just one moment please and pick the phone up call the boss and come back to give the answer saying that he was new there. Now if he was new and didnt know how to run it. Why is he left to run it unsupervised.
Now I could go on but that is about it in a nutshell and needless to say i will not be returning to this restaurant in the future.
From: 08 May 2018
To: 08 August 2018
Max: 8
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Monday I had an appointment with one of my several doctors and, unusual for me -- but understandable as I was in a hurry -- I forgot to bring along a book to read (I had planned to bring The Collapse of the Third Republic, which I am reading yet another time). So, I had little choice but to glance through the magazines in the waiting room. Having little interest in the plethora of "women's magazines" or their male counterparts (everything from "Men's Health" to "Sports Illustrated" to a few of those Maxim-with-more-clothing horrors), I finally found a copy of "Time". As I had just jokingly dismissed "Time" in a conversation with my mother as "not even up to Newsweek quality", I decided to check it out and see if it had improved in the decade since last I read it. And I was somewhat surprised to find a mention -- if only a fleeting one in an interview -- of a topic which has come to my attention several times recently.
As I mentioned in a number of earlier essays (eg "Making Grievances Worse", "A Brief Aside", "The Urge to Simplify", "Coming Attractions - 2015, June 13") I have recently spent some time reading web sites which apply "lit crit" approaches to popular culture, especially television/films and video games, and either within those sites, or in sites to which they frequently link, I have also been reading a lot of sites which focus on social justice concerns, especially sexism, racism and related topics. There are a number of issues which these sites have raised, some of which I have already discussed, others which I plan to examine in the future. One of these is the use of the "trigger warning" on various blog entries. And it was that which was mentioned in the magazine.
In an interview with one time young adult writer, now adult novelist, Judy Bloom, the interviewer asked about her feelings on the use of "trigger warnings" on various works, including short stories and novels. Ms Bloom responded, in my mind much to her credit, by associating such warnings with more intrusive types of censorship, arguing that such warnings are just another attempt to exclude anything challenging or potentially disturbing, which she explicitly equated to more conventional forms of censorship, presumably because she assumes such "trigger warnings" would be used to exclude such works from classes, school libraries and the like.
When I first ran across "trigger warnings", they were most used on the more feminist sites, mostly when the blog entry in question dealt with rape, domestic violence or other topics which one would presume would trouble certain people. However, even then, it troubled me. First, the whole term just sounds a bit silly. As the title of this essay implies, the first thing I thought of when hearing the term was Moe Fine hearing someone mention Niagara Falls. In my head, I kept hearing "slowly I turned, step by step, inch by inch...". I could not think of anything else. The very suggestion that something could be a "trigger" seemed so absurdly mechanistic an approach to humanity, that Niagara Falls was the only analogy that came to mind.
But after giving it more thought, two other, more serious, complaints came to mind.
First, it was troubling that those placing such warnings saw their fellows as so weak, so easily damaged, that they needed special labeling. When people claim men view women as weak and over emotional, they may have a point for some men, but it strikes me that many feminists, such as those insisting on such warnings, are even more responsible for reinforcing such stereotypes. After all, I can't imagine men insisting on warnings on blog entries that have specifically male-troubling matters. Yet, out of an excess of sympathy, feminists manage to create stereotypes more troubling than any man ever has.
The second concern is more in line with my usual worries, and that is "where does it end?" After all, pick anything you like, and someone out there is troubled by it. As the title suggests, even Niagara Falls worries at least one person. So, if we must label everything that might "trigger" someone, where do we draw the line? Why not just label everything and be done with it, since I am sure someone is offended by nearly anything one cares to name?
I had a similar reaction to excessive reactions to allergies, especially among children. Now, I am not unsympathetic, if an actual child has an actual allergy in a class, I have no objection to avoiding the substance to which the child is allergic. Where my problem arises is when people suggest preemptive measures, such as banning all peanuts in a locale, in case someone is allergic. It seems to me this simply ends up banning select allergies, usually the "allergy du jour", while ignoring equally common and deadly allergies. For instance, while peanuts are often excluded from places, how often have we heard the same for shellfish, or milk, both of which are equally, or more, common, and in the case of shellfish, often just as deadly in a handful of cases? As I said, I am not opposed to sensible measures for known issues, or even taking extraordinary steps should someone with allergies request them, but to make them in advance, just to show we are in sympathy with the cause of the day, that seems pointless, and that is how these "trigger warning" strike me.
And now, since I resisted doing it every time I mentioned the title (I thought of including it in a footnote attached to each mention of the title), allow me to close out "Niagara Falls." Niagara Falls? Slowly I turned. Step by step, inch by inch...
Thank you! Thank you! I will be here all week. And remember to tip your server. (Sorry, could not resist. For some reason, it feels like one of those days.)
I actually have planned for a while to discuss the health fetish of the day phenomenon, such as the current trendy statement "gluten free", promising the worried well they will not be exposed to something that will do 99.9999% (or likely 100%) of them no harm at all. I had to laugh when I saw that even my vitamins were declaring themselves free of gluten. Of course, this is just the latest in a long line of absurd health fads, based on imaginary benefits to some foods (whole grains, acai, soy, raw foods, etc) ,the belief that most of us suffer from a misunderstood and rare ailment (celiac disease, Lyme disease, etc) or the belief specific foodstuffs are inherently harmful (bleached flour, sugar, transfats, gluten). I will write more about this later.