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Some people can't get enough of deviled ham, and this recipe is an easy and convenient way to enjoy it in the form of a spread.
This recipe was adapted from Salty Snacks: Make Your Own Chips, Crisps, Crackers, Pretzels, Dips, and Other Savory Bites by Cynthia Nims, copyright © 2012. Published by Ten Speed Press, an imprint of the Crown Publishing Group. Photo Credit: Jennifer Martiné.
Combine the ham and pickled peppers in a food processor and pulse until they are finely chopped and well blended, scraping down the sides as needed. Avoid overprocessing; the mixture should have a bit of a coarse texture, not become a smooth puree.
Add the mayonnaise, vinegar, and mustard to the processor and pulse three or four times to blend. Taste the mixture for seasoning, adding a bit more vinegar or mustard to taste. If the mixture is a bit dry, add another tablespoon or so of mayonnaise for a more spreadable texture.
Transfer the deviled ham to a serving bowl. If you are not serving right away, cover and refrigerate until you are ready to serve. The flavor will be best if made at least 2 hours in advance, but it can be prepared up to 3 days ahead. Allow the spread to come to room temperature before serving.


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1975 Topps Set Card 154/660 – #22 – Dave Cash, Phillies
Progress: 154/660
Player Name: Dave Cash
Team: Philadelphia Phillies
Position: 2nd Base
Image Style: Posed Fielding
Years In The Major Leagues: 12 seasons, 1969-80
Notes From His 1975 Season: Dave Cash played in a league-high 162 games during the 1975 baseball season. He made a league-high 766 plate appearances during the season while connecting for a league-high 213 hits and a .305 batting average. Of his 213 hits, Cash collected 40 doubles, 3 triples, and 4 home runs.
Notes From Career: Dave Cash spent his 12-year playing career with 4 different clubs. He was named as an All-Star during each of his three seasons with the Phillies from 1974-76. He has 1,571 career hits with 426 RBI and 732 runs scored. Cash is a member of the 1971 World Series championship winning Pittsburgh Pirates.

subset: commoncrawl


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I decided to join Twitter.
Perhaps it was out of some unspoken desire to scream in miniature. Maybe it was because I feel that brevity IS Godliness and Twitter has finally presented me with the platform I've been dreaming of. Then again, maybe I just had nothing better to do and five minutes worth of time to do it in.
Twitter is where non-sequiturs go to die; quickly and exponentially. Imagine a place where everyone speaks in bumper sticker . . where greeting cards seem verbose . . where you get all the news that's print in fits . . where Ashton Kutcher is Tolstoy.
The micro-blogging blue bird bingo set is allowed up to 140 characters with which to wax metaphysical. Woody Allen movies contain more characters than that. In fact, if this were a Tweet
(Sorry, that was Twitter humor.)
Twitter Quick Quiz: What do these statements have in common?
The comedian Jim Gafigan was once in the witness protection program for making fun of PETA . . Adam Richman is secretly a vegetarian . . Chelsea Peretti once dated Jose Canseco without his knowledge . .Kim Kardashian goes to church . .
If you said they were all ridiculous, give yourself a point. If you said they were all false excepting for Kim Kardashian going to church, you're on Twitter.
I'm tallying a grand total of 3 followers on Twitter. A guy named Rob who is into gadgets, the witty wordsmith Simone Benedict (to whom I owe the inspiration for this post), and someone named Inge. I don't think Inge is a real person, but I'm leaving it be since three followers is, like, way more impressive. Than two.
Presently, Twitter is a weekend indulgence for me. There's only so much Chad Ochocinco knowledge I can digest before a lobotomy needs to happen. Once I get cracking though, Lady Gaga best watch out.
Well, if I had twenty million years maybe. Because that's how many followers the Empress of Excess is toting around. Wow, Twitter has discovered a way in which Lady 2G can leave even less to the imagination. That's pretty Machiavellian of 'em, don't ya think?
Eh, it's all good. Considering as how the White House is only half as popular as Lady G Sport (they have 10 million followers). Good going on that whole priority thing, America. In fact, the only time the White House gets any real buzz on its Twitter page is when it decides to "Rick Roll" its followers.
If you're not familiar with this Rick Roll business (I wasn't), it's pretty simple (stupid) actually. You provide a teaser in the form of a link and when the person clicks on it, they are ambushed with the Rick Astley musical embolism, "Never Gonna Give You Up". The White House twitter page blew up thanks to this stunt. Which begs the question, how can Syria top that?
The only reason I'm leaving my Twitter page here is 'cause I trust the good people who follow this blog not to make fun of me. I'm new to this whole Twitter thing, but I'm learning.


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Now I kind of want to do the blind fold for Balimora lol so many ideas!!
SOLVED: Fragment Twelve: Spell Creation
You are making a blindfold. That blindfold should look like it represents balimora.
Which guild are you, btw? It's not listed in your profile and you don't have it set in your title.
Balimora through and mostly through lol
I'm Balimora. Sorry for the confusion, I have a habit of overthinking things and wanted to make sure that it was indeed a blind fold.
Go there and join the group, that way people know just by a glance. It'll put your guild right next to your name. Like on my posts.
I'm already part of it. I don't have the title for some for some reason though.
Thanks! I had it by my name for a brief bit but then removed it. Am I proud to be of Balimora? Of course! That is and should never be in question… I simply dislike associating strictly as one thing or another lol
Sorry! I didn't know.
Would you prefer to do the blindfold for Balimora? Should we wait for others who are Balimora a smidge more time to voice if what part they'd like to volunteer for?
Na, it's okay. I just guessed that once you used another title it went away. But thanks for trying to help anyway.
Haha no worries!! If I sounded offended it's because you can't hear the smile in my voice through messaging
I'll do the blindfold if it's okay with everyone. I'm just volunteering since I know some people are busy at the time it's happening. If others would like to vote, I'm not getting in the way. But I do want to do it really badly.
Then I think you should do it! Sign your name on the word doc thingy so others know though!
Ok, thanks!
Now recap - We have two spells, that each need 6 casters.
Part One: Fern and Ways' Concealment
The Ore of the earth is black like coal
The Tides conceal what lies beneath
The Wilds surround and swallow you whole
The Light untouching around you wreathes
The Aether now your sound has stole
And The Thoughts of you all minds must sheath
Now carry out the task you were bidden
By the Six you are now hidden.
The phrases will be said in round fashion and the spell ends with the 6 casters saying the final two lines in sync.
Each element specific line will be said by the caster of the guild it is associated with.
Ore - Flinterforge
Tides - Ebenguard
Wilds - Balimora
Light - Weatherwatcher
Aether - Gossmere
Thought - Thornmouth
Part Two: The Mountain's Shroud
This spell entails 6 more casters, one from each guild, who have created a blindfold representative of their element/guild. They will don the blindfolds a few minutes after the completion of the first spell.
The timing on these spells needs to be impeccable. If Marty or Whistler are seen once the entire mission could go south.
That'll require some communication from you, @Marty.60.
So sign ups are at this link. We need to be organized, efficient, and timely with this spell. So get your head in gear, because, fellow Mountaineers, we have work to do.
I'm clapping just for you typing this up. And thank you for this, some of us, mainly me, needed it.
I could potentially participate for Thornmouth if we're in an absolute pinch. I work nights so I'm not usually awake at that time, but I could get up a little early on Tuesday if we don't have any other Thornmouths available.
You all know I'm available to pull however I'm needed. Just let me know.


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Dr Yemon ChoiLecturer in Pure Mathematics
Research Interests
The keyword version
Banach and operator algebras. Noncommutative harmonic analysis. Categorical and homological perspectives on functional analysis.
The longer version
I am interested in a range of topics and problems on the interface between algebra and functional analysis. This tends to be driven by particular families of examples, but my preference is for finding general frameworks that unify common features of these examples, once one has investigated individual examples in depth. "Hacking out lots of estimates and then trying to exploit functorial behaviour" is not the most accurate description, nor the most catchy one, but it gives some idea of what I spend my research time doing.In recent years I have worked intensively on various aspects of the Fourier algebras of locally compact groups: studying these objects involves a blend of (non-commutative) harmonic analysis and representation theory. Many of the developments over the last 20 years or so use the tools, or are guided by the philosophy, of the theory of operator spaces and completely bounded maps -- these may be thought of as enriched versions of Banach spaces and linear maps between them, where one allows matricial coefficients and not just scalar ones.
I am also interested in algebras of convolution operators arising from the canonical representation(s) of a group G on the Banach space Lp(G). When p=2 there is a rich theory available, from the world of C*-algebras and von Neumann algebras; for other values of p many basic structural questions remain unresolved, even for very explicit examples such as G=SLn(R) or SLn(Z).
Web Links
Professional Role
Postgraduate Tutor for Research Students (Mathematics)
Departmental Academic Officer
Departmental Study Abroad Tutor (from Oct. 2018)
PhD Supervisions Completed
Mahmood Alaghmandan, 2013. (Supervised at the University of Saskatchewan, Canada, joint with E. Samei)
Career Details
Jan. 2014 - present: Lecturer at Lancaster University, United Kingdom
Aug. 2010 - Jan. 2014: Assistant Professor (tenure-track), University of Saskatchewan, Canada
Aug. 2008 - Jul. 2010: Postdoctoral researcher, Universite Laval, Canada
Feb. 2007 - Jul. 2008: Postdoctoral fellow, University of Manitoba, Canada
Sept. 2002 - Jun. 2006: PhD student, University of Newcastle upon Tyne, United Kingdom
Sept. 2001 - Jun, 2002: Editorial assistant, National Extension College, United Kingdom.
B.A. in Mathematics (2000, Cambridge).
CASM (2001, Cambridge).
PhD in Pure Mathematics (2006, Newcastle-upon-Tyne)
PhD Supervision Interests
I am interested in hearing from suitable applicants wishing to start in 2019-20 or later.
Current ideas for PhD projects
Here are four possible areas in which I would currently be willing to supervise: each of these is not a specific PhD project, but a setting in which there are various possible research problems that a student could work on. I hope to add more details, or links to more details, in the near future: if you would like to know more then please feel free to get in touch.
- Algebras of convolution operators on Lp spaces
- Cohomological invariants for Fourier algebras
- Homological algebra for dual Banach algebras and their modules
- Classification problems for l1-semigroup algebras
Warning notes.
Themes 1 and 2 are likely to require some prior exposure to the basic theory of C*-algebras. However, some of the necessary background can be learned in the initial stages of the PhD, and depending on the individual strengths of an applicant there may be particular projects that require less functional-analytic machinery; some questions may be suitable for those with solid basic analysis and interests in the representation theory of finite groups.
It is possible that you are reading this and have had some exposure to various structural properties of Banach algebras known as "approximate amenability", "character amenability", or "module amenability". I will not, for the foreseeable future, supervise on any of these three, nor on any hybrid of these.
("Connes-amenability", on the other hand, is related closely to Theme 3 above, but be warned that this is an area with some nasty traps for the novice, primarily because dual Banach algebras are in some sense still not really understood.)
Twisted tensor products, and cocycles on Fourier algebras
Invited talk
Some results on direct finiteness of group algebras
Invited talk
CAP and ITAP for group von Neumann algebras
Invited talk
Derivations on semigroup algebras and Fourier algebras
Invited talk
Unitarizable group representations and amenable operator algebras
Invited talk
Weak amenability of Fourier algebras: old and new results
Invited talk
- Analysis and Probability


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I just want to fill my car up with gas and split.
Just drive.
To where ever.
Today, with The Cake Lady, I saw this whole camping set (tent, sleeping bags... ummm... other camping stuff) for like a hundred bucks and I wanted to buy it.
The girl who loathes and abhors camping.
I'm bored.
Of course, I have a few trips planned over the next few months so hopefully I will get all of this out of my system.
The first one should do it seeing as how I will spend at least six hours in the car with my lovely daughters as we drive the Death Road to Dallas. Yeah, you say highway but once there are those stupid fucking concrete partition thingys, I say Death Road. Six. long. hours. up there and six. long. hours. back.
That'll probably chase that nasty bug away.
But just in case it doesn't, there is a trip to the coast in the making right now for July.
And seeing as how I just spent like five hours checking out hotels and motels and beach houses, if you are looking for a recommendation of where to stay anywhere in or around Padre Island, do holler at your girl here.
I am especially looking forward to this trip on account of the two bloggers that are going with me (so far anyway... any other takers?? lol). One of them, I've met and the other I've known online for quite some time and bless her heart if she hasn't had her fair share of Kate Calls.
Don't know what a Kate Call is?
Ahhh, ask The Cake Lady or Jiffinner what happens when I call them.
Or Mr. Toddy.
All of which can tell you, if you ever give me your phone number, hours and hours are spent listening to me babble.
Because I can babble - a. lot.
Anyway, I certainly hope that I can kick this bug since I am down to like six vacation days and four of them will be used after the two aforementioned trips.
Just in case I can't though, where do you recommend going?
Labels: Beach Trip, my crazy life


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NEW YORK - The University of Michigan's final January consumer sentiment index reading was 72.5, compared to the final January 75.0, the preliminary January 74.0 reading, and the December 69.9, according to market sources.
The expectations index was 68.0, compared to 69.1 in January, 68.4 earlier in the month, and 63.6 in December.
The current conditions index was 79.6, compared to 84.2 in January, 82.6 earlier in the month, and 79.6 in December.
Economists polled by Thomson Reuters had predicted a 74.0 reading for the main index, 84.2 for current conditions and 69.1 for expectations.
The five-year inflation expectation index was 2.9%, compared to 2.7% in January, and 2.7% in December, while the one-year inflation expectation index was 3.2%, compared to 3.3% in January, and 3.1% in December.
The University of Michigan index is not released to the press, but only to paying subscribers.


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How should companies use the data from these sources to support increasing their spend put through e-procurement tools such as reverse auctions?
Reviewing why retailers do not have continuing success when running prior e-procurement events over again, one area of commonality is a lack of new suppliers. Another is the price being too high for the same event that has already been built and will result in lower savings the 2nd and 3rd time around.
There is a proper way to insure the sustainability of your reverse auctions going forward. Following these guidelines will also encourage senior managements consideration of placing more spend under the control of e-procurement tools and specifically reverse auction tools.
Once you are armed with a robust retail supplier database and related tools such as the SafeSourcing® SafeSourceIt™ tool set:
1. Conduct a detailed category discovery
a. Learn all there is to learn about the retailers way of doing business.
b. Walk distribution centers and warehouses
c. Walk an array of stores and understand all formats of the enterprise.
d. Compile a list of all corporate categories
2. Rank categories by
a. Total spend
b. Importance
c. Sourcing frequency
d. Quality objectives
e. Look for aggregation opportunities
i. Lighters, lighter fluid, flints, fire sticks.
3. Conduct supplier discovery
a. Rank suppliers
i. Size
ii. Experience
iii. References
iv. Environmental certifications
v. Safety Certifications
4. With all of the above in hand; develop a three year game plan
a. Identify suppliers for each event over the three years
b. Develop savings targets by category
c. Develop a three year time line for all categories
5. Role Play internally the first year for a test category
a. Ask the following questions
i. How will you award the business
ii. Review alternate scenarios
iii. Review savings by scenario
iv. Determine which suppliers will be invited back
v. Determine what new suppliers from your database search will be invited next year
We look forward to and appreciate to your comments.


text:
and sugar... and you get cake?
Where did the glue go?
You know darned well where it went!
That's what makes the cake Stick to your BUTT
Ay yi yi!! I can relate allllll too well to that one.
Though according to my last doctor's visit (Tuesday), I'm losing weight. I knew I was just by the way things fit, but it's nice to have official verification. :)
There's water in cake?
I like the first pig picture. Ours never line up that neatly; even when they're eating, they're jostling each other around.


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To put it simply, the fact the Cambridge Analytica had this data means that the Trump campaign was able to illegally target – with great accuracy – the exact demographic of people they wanted to indoctrinate with messaging through Facebook advertising.
The Guardian reports "a whistleblower has revealed to the Observer how Cambridge Analytica – a company owned by the hedge fund billionaire Robert Mercer, and headed at the time by Trump's key adviser Steve Bannon – used personal information taken without authorisation in early 2014 to build a system that could profile individual US voters, in order to target them with personalised political advertisements."
Christopher Wylie worked with a Cambridge University academic to obtain the data, according to the Observer: "We exploited Facebook to harvest millions of people's profiles. And built models to exploit what we knew about them and target their inner demons. That was the basis the entire company was built on."
This was cheating. There's no other way to describe it. This is, quite literally, the 2016 equivalent to the Richard Nixon scandal where burglars broke into the Democratic National Committee headquarters to steal secret information to use against his opponent.
Bill Palmer explains it like this: "All along we've been waiting for the smoking gun that would prove the Trump campaign was using voter registration data, or DNC email data, stolen by Russian hackers. We know the Russians stole that data. We know members of the Trump campaign communicated with the Russian hackers, and with their WikiLeaks intermediary. The circumstantial evidence is overwhelming, but we have not yet seen proof that this data stolen by the Russians was in fact used by the Trump campaign. That may come out before much longer, but as of today we don't need that proof in order to conclude that Trump really did cheat."
Cambridge Analytica obtained user data from approximately 50,000,000 Facebook users in a manner that violated Facebook's policies and used the data to help get Trump elected. I can't say it enough…that's cheating. Hillary Clinton lost the election in part due to this cheating.
Of course, we are still waiting on the Robert Mueller investigation to concluded in regards to alleged Russian interference, but the data breach element alone confirms that Donald Trump's campaign used stolen voter data – through Cambridge Analytica – to swing the election.
It couldn't be more obvious. Donald Trump did not win the election legitimately, and the Cambridge Analytica aspect of the scandal only helps confirm as much.


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As you may or may not know the second round of Stamp with Us has started. Pictured is the first project that Monica posted for us. Aren't they cute!
Any little girl would love to have their own stylish high heeled shoe filled with lollies, with handbag card to match. These would be great for any little girls party. (Some big girls may even like their own)
The flower on the front of the shoe is demonstrated on video at the above mentioned site, and the purple sequins on both the shoe and handbag finish the project off nicely.
You too can join in the fun at Stamp With Us.
Love to read the lovely comments that are left on my blog. Thank you to those who do take the time!
So once again, have a great day or night where ever you may be!
Wednesday, August 5, 2009
Tuesday, August 4, 2009
Stamp with Us - Sketch Challenge
Here is this weeks challenge over at Stamp with Us. I hope you like what I came up with!
I used the stamp from Friends 24/7 and colored the different aspects of the stamp with my markers - Real Red, Choc Chip and Certainly Celery.
I used Whisper White and Real Red cardstock along with a beautiful paper from Graphic 45 called Secret Garden from the Botanicalbella Collection.
Hello to all those lovely Stampin' Up sisters who are attending their convention in Utah, USA this week. Hope you all are having a great time.
As for the rest of us, enjoy you day or night where ever you may be!
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I have the sneaking suspision that a season of change is about to decend upon us.
I can feel the way I used to solidly see things and belive them to be changing out from under me. Some of the things I'd thought would be forever constants seem to feel less permanent.
There are other things that in the past I thought oh, I'd never have the energy, patience or whatever to do that or go there or play that game and now it seems the rules are changing. There are all kinds of things that I'm thinking no, I'm about ready to play and I'll play by your rules.
Lots of things have a season and then you out grow them or their purpose has been served and it's time to move along. It's not bad, not at all, it just means that life has kept on moving and I'm at least aware enough of it's passing to be trying to guage if I'm doing the right things in the right places.
Big and little, those changes are comming for us. Better be getting ready.


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The normal pattern on Sundays is that we drive to the market in Esperaza, have breakfast overlooking the hustle and bustle, make our purchases, then drive on to Quillan, where Gay drops me for my mainly off-road walk up the massive hill and on to home. Today that was impossible because the D117, which climbs the hill to its high point of 601 metres, was closed to normal traffic because, annually, the road becomes a race-track for the weekend. All sorts of hotted-up road cars and a number of racing cars race up the hill from top to bottom. I think all this takes place against the clock - competitive time trials. There is not room for overtaking on that road - not that this stops normal road users.
Although my walk is on tracks, I have to cross the D117 at one point, which is impossible while all this is going on. Also, Gay would not be allowed to drive up the hill. So I had an on-road walk today, directly home from Esperaza. The road was much busier than usual because of all the diverted traffic because of the race/time trial. Nevertheless, I was home by lunchtime, with another 20 kms under my belt.
My total for the week is 115 kms, 1848 for the year to date, still far ahead of my target of an average 10 kms per day.


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Sunday, November 21, 2010
2 Comments:
- studio lolo said...
I just don't know how to comment about this without going off on a lost youth tangent.
Let's just say I'm more than feeling my age and years just clicking by.
I do love your rich color narratives.
- Gai said...
very deep and interesting image of sneaky
Subscribe to Post Comments [Atom]


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(262) 284-6850
July 10th - 19th, 2018
By Rick Compton & Betsy Bennett
It's time to party like it is 1969! We all have to laugh at ourselves about the frailties of growing older or we may become very angry people.
Welcome to Pelican Roost, a full service retirement village for those embracing their twilight years (and the wackiness that comes along with them). It is home to some very colorful characters who definitely aren't your average Boggle and Dominoes playing bunch. Pelican Roost is a place where buffoonery lives next door to screwball, just across the way from cockamamie! It's like having a blind date with a real memory problem! The show's host couple enters heaven, suspecting their son pulled the plug to get his hands on Dad's vintage Corvette. They don't seem to mind—instead they take the audience on an uproarious journey that celebrates the latter years. This delightfully funny show pokes fun at the senior situations that seem to constantly bombard us as we get older. This vaudeville-esque revue will definitely knock you off your rocker!
Matinee Performances:
Doors Open at 11:45 am
Dinner Begins at 12:30 pm
Show Begins at 1:45 pm
Evening Performances:
Doors Open at 5:45 pm
Dinner Begins at 6:30 pm
Show Begins at 7:45 pm
Buffet July 17 Evening
Plated July 10-12 and 17-19
Vegetarian Option Cheese Tortellini with Alfredo Sauce


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The film recounts how a group of Mexican-born students from a beleaguered Arizona high school trumped opponents from the esteemed Massachusetts Institute of Technology in a 2004 underwater robotics contest sponsored by NASA and others. Interviews with the original challengers, the resourceful underdogs from Phoenix's Carl Hayden Community High School and the more seemingly privileged contestants from MIT, are effectively mixed with actual footage from the 2004 contest. The film also incorporates modest reenactments of the Arizona kids' preparation for the event and presents a cogent case why, for the good of the United States and its future, Congress should pass the Dream Act and other pending immigration reforms.
Official Site: www.underwaterdreamsfilm.com
Director: Mary Mazzio
Writer: Robert Fitzgerald, Carla Mazzio, Jay Mazzio and Mary Mazzio
Cast: Michael Pena
Sorry there are no upcoming showtimes for Underwater Dreams


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and barely enough to cover the ground.
Can't say how long it's been since
we've built a snowman.
and the grocery stores
are filled to overflowing.
everything shuts down.
In 1972,
we had a miracle.
A few flakes of snow,
and we were sent home from school.
I was too excited to sleep.
This 12 year old girl was more than excited!
I awoke to a foot of snow
and it was still falling.
By mid-day it was to my knees.
I prayed the sun would not come out.
I wanted SNOW!
Never have I seen anything as bright.
We never got snow like that again.
The photo below was taken at the homeplace
the winter before my parent's died.
I sure hope there's snow in heaven.
Mama was a kid at heart,
and she loved to play!
Let it Snow, Let it Snow, Let it Snow,


text:
A gentle facial scrub can be used two or three times a week to smooth the skin by removing surface dead skin cells. Cosmetic clay helps absorb excess oil, and a combination of finely ground almonds and oats gently exfoliates skin. Oats also help soothe skin irritation, while eucalyptus and lavender essential oils combat bacteria.
Laurel Vukovic writes and teaches about herbs from her home in southern Oregon. She is the author of 1,001 Natural Remedies (DK, 2003) and Herbal Healing Secrets for Women (Prentice Hall, 2000).
Click here for the original article, Herbal Acne Remedies.
where do you get white cosmetic clay and what is it?
Sit in on dozens of practical workshops from the leading authorities on natural health, organic gardening, real food and more!LEARN MORE


text:
Search For Articles :
Entries for Scientific Index
|Author 1
|Author 2
|UML-Profile for Metamodel-Driven Design of Database Applications
|Pavel P. Oleynik
|Vasyliy I. Gurianov
The article presents a UML profile for a software development environment Sharp Architect RAD Studio. This tool is intended to agile design of object-oriented databases. The main part of the article contains the description of the profile metamodel. There is an example of the profile usage. At the end of the article the authors draw some conclusions and plan future works.
|Characterizing Faults on Real-Time Systems Based on Grid Automata
|Adilson Luiz Bonifacio
|Gilson Doi
Real-time systems are, in general, critical systems that interact with the environment through input and output events regulated by time constraints. The testing activity on systems of this nature requires rigorous approaches due to their critical aspects. Model-based testing approaches rely on formalisms that provide more reliability to testing activities. However, a model-based testing approach for real-time systems depends on techniques that can deal with continuous evolution of time appropriately. Several testing approaches apply discretization techniques in order to represent continuous behavior of timed models. Test suites can then be extracted from discretized models to support conformance testing between specifications and their respective implementations. Therefore an evaluation of test suites considering a fault coverage is an important task, but rarely addressed by model-based testing approaches for real-time systems. In this work we propose a systematic strategy to identify faults in TIOA models based on their corresponding discretized models. We precisely define a fault model to support model-based testing activities such as coverage analysis and test case generation.
|A Simple Heuristic for Basic Vehicle Routing Problem
|Nodari Vakhania
|Jose Alberto Hernandez
The vehicle routing problem is an important real-life transportation problem. We propose a two-phase construction heuristic for the solution of the classical Euclidean (uncapacitated) vehicle routing problem in which the minimum cost distinct vehicle tours are to be formed for the given customer locations. At the first phase we construct a polygon in the 2-dimensional Euclidean space that girds all the given points (customer locations and the depot). The second phase consists of two stages. At the first stage the interior polygon area is partitioned into triangle areas, and at the second stage the tours for each of these areas are constructed.
|A Metamodel Proposal for a Web Development Code Generation Tool
|Cristina Magaña
|Zuriel Morales
Code generation is an important part of Model-Driven Development as well as the abstract representation of the software functionality. One of the strong deficiencies in this paradigm is the lack of research projects regarding to code generation that uses the terminology applied in the industry. In order to ameliorate this scenario, in this work is presented a metamodel proposal for a Web development code generation tool. This proposal is based on the terminology used in the industry for Web development in the region of Sinaloa, México. This is an extension and updated explanation of our work previously presented in a conference.
|Neural Network for Large-Scale Problems, with Application to Human Motion
|Mohammad Bataineh
|Timothy Marler
As the potential applications for artificial intelligence, and thus neural networks expand, and as the prevalence of big data increases, the need for improved training in neural networks that leverage data sets efficiently will soon surface. In addition, research in the field of human simulation has led to significant advancements in quality, time, and cost management for products like military and athletic equipment and vehicles. There is, however, a critical need for human simulation models to run in real time, especially those with large-scale problems like motion prediction (a single motion problem involves prediction of between 500-700 outputs). Hence, this work addresses both challenges by introducing a modified training process for an artificial neural network (ANN) that is capable of mitigating memory issues and improving accuracy with large scale problems that involve minimal taring data. The new modified ANN design is successfully tested on two common human-motion tasks, walking and going prone. Through comparison with a benchmark ANN, the results of the new network are shown to be accurate objectively and subjectively.
|Recognition for Objects by Relationships Between Attributes
|Hiroka Horiguchi
|Kazuo Ikeshiro
Object recognition methods based on attributes have been studied. Conventional methods recognize objects by the presence or absence of attributes. However, the conventional methods have two problems. Firstly, the conventional methods are not able to recognize a target object of which a part of attributes is occluded. Secondly, the conventional methods miss-recognize a target object, which has irrelevant attributes. Therefore, to solve these two problems, we propose the object recognition by relationships between attributes. In this paper, we focus on the face as the recognition object. The proposed method uses relationships as constraints for object recognition using attributes. The proposed method applies two major type constraints. The first constraint is a local constraint, which is applied to a part of attributes. To achieve robust face recognition against occlusion scenes, the proposed method uses the local constraint. And then, the second constraint is a global constraint, which is applied to all attributes. To achieve robust face recognition against irrelevant attributes, the proposed method uses the global constraint. In this paper, to evaluate the effectiveness of the proposed method, we compared the proposed method with a conventional method. We experimented in normal face, occlusion and irrelevant attributes. We used 2580 images of a face which are changed in scale and rotation. Experimental results showed that the recognition ratio of the proposed method is equal to or more than that of the conventional method in normal face, occlusion, and irrelevant attributes.
|GGDML: Icosahedral Models Language Extensions
|Nabeeh Jumah
|Julian Kunkel
The optimization opportunities of a code base are not completely exploited by compilers. In fact, there are optimizations that must be done within the source code. Hence, if the code developers skip some details, some performance is lost. Thus, the use of a general-purpose language to develop a performance-demanding software -e.g. climate models- needs more care from the developers. They should take into account hardware details of the target machine.
Besides, writing a high-performance code for one machine will have a lower performance on another one. The developers usually write multiple optimized sections or even code versions for the different target machines. Such codes are complex and hard to maintain.
In this article we introduce a higher-level code development approach, where we develop a set of extensions to the language that is used to write a model's code. Our extensions form a domain-specific language (DSL) that abstracts domain concepts and leaves the lower level details to a configurable source-to-source translation process.
The purpose of the developed extensions is to support the icosahedral climate/atmospheric model development. We have started with the three icosahedral models: DYNAMICO, ICON, and NICAM. The collaboration with the scientists from the weather/climate sciences enabled agreed-upon extensions. When we have suggested an extension we kept in mind that it represents a higher-level domain-based concept, and that it carries no lower-level details.
The introduced DSL (GGDML- General Grid Definition and Manipulation Language) hides optimization details like memory layout. It reduces code size of a model to less than one third its original size in terms of lines of code. The development costs of a model with GGDML are therefore reduced significantly.
|Analyzing the Information Search Behavior and Intentions in Visual Information Systems
|Kawa Nazemi
|Dirk Burkhardt
Visual information search systems support different search approaches such as targeted, exploratory or analytical search. Those visual systems deal with the challenge of composing optimal initial result visualization sets that face the search intention and respond to the search behavior of users. The diversity of these kinds of search tasks require different sets of visual layouts and functionalities, e.g. to filter, thrill-down or even analyze concrete data properties. This paper describes a new approach to calculate the probability towards the three mentioned search intentions, derived from users' behavior. The implementation is realized as a web-service, which is included in a visual environment that is designed to enable various search strategies based on heterogeneous data sources. In fact, based on an entered search query our developed search intention analysis web-service calculates the most probable search task, and our visualization system initially shows the optimal result set of visualizations to solve the task. The main contribution of this paper is a probability-based approach to derive the users' search intentions based on the search behavior enhanced by the application to a visual system.
|A Process Model for Simulation the Growth and Development of Sweet Sorghum
|Ning Xia
|Aishuang Li
This paper presents a process model of sweet sorghum growth and development which reconstructs realistic 3D images of sweet sorghum with geometric and topological characteristics, and makes it possible to view actual stalk, spike motion from a variety of angles when necessary. Model can also be rotated and the 3D images can be zoomed in and out at a high level of fidelity. They are also used to generate other plant species for use in analyzing the interplay between stochastic and deterministic processes.
|GABA-Ergic Premedication and Hemodynamic Stability during Induction Laryngoscopy Phase of General Anesthesia
|Tabish Hussain
|Asifa Anwar Mir
introduction: Gabapentin is a second generation anticonvulsant that is effective in the treatment of chronic neuropathic pain. Recent data suggests its perioperative administration for attenuation of the hemodynamic response to laryngoscopy and intubation. The aim of this study was to compare Oral Gabapentin premedication with no premedication in patients undergoing rigid laryngoscopy and endotracheal intubation for General Anaesthesia in terms of mean heart rate and mean arterial pressure.
Conclusion:800 mg oral gabapentin given 1 hour before undergoing rigid laryngoscopy and endotracheal intubation for general anesthesia significantly affects mean heart rate and mean arterial pressure at 1st, 3rd, 5th and at 10th minute.
|Evaluation of Essential and Toxic Elements in Blood Samples of Male Smokers Having Different Types of Cancers with Reference to Healthy Male Smokers
|Tasneem Gul Kazi
|Sham Kumar Wadhwa
Immense epidemiologic studies have been reported about the role of essential trace and toxic elements as risk factors for incidence of different type of cancers in population of developed and developing countries. In present work the levels of carcinogenic, Arsenic, Cadmium, and Nickel (As, Cd and Ni) and anti-carcinogenic, Zinc and Selenium (Zn and Se) elements were measured in blood of male cancer patients (urinary bladder, lung, mouth and esophageal) and healthy referents. The all patients and referents were smoker. The blood samples were analysed with atomic absorption spectrometry after microwave assisted acid digestion. The resulted data indicated that the levels of toxic elements As, Ni and Cd were considerably elevated whereas essential elements, Zn and Se were lower in blood samples of all cancer cases as compared to those values found in noncancerous subjects. As the levels of essential trace elements were low in blood samples of male cancerous patients but difference was highly significant in lung and mouth cancer subjects (p<0.001), whereas sequence of decreasing order was not uniform. The levels of Zn in blood samples of different cancerous patients were found in decreasing order as: esophagus< mouth< urinary bladder
|Genetic Variability Within ADA Gene and Susceptibility to Type 2 Diabetes in Obese Subjects
|F. Gloria-Bottini
|M. Banci
The complex relationship between adenosine, obesity and Type 2 Diabetes (T2D) prompted us to investigate a possible role of genetic variability within adenosine deaminase (ADA) gene in the susceptibility to T2D in obese subjects. With enzymatic activity ADA contributes to the regulation of adenosine concentration in body fluids and as ecto- enzyme modulates signaling events involving adenosine receptors on cell surface.
Three polymorphic sites within the ADA gene, ADA1 (exon 1), ADA2 (intron 2) and ADA6 (exon6) were examined in 299 subjects from the White population of Rome admitted to the Hospital for cardiovascular diseases. Each site shows two alleles: the alleles with higher frequency are ADA1*1, ADA2*1 and ADA6*2.
Informed consent was obtained by the patients to participate to the study that was approved by the Council of Department.
For the three sites examined the relative risk of T2D in obese subjects (vs non obese) is higher in carriers of the homozygous genotype for the allele with higher frequency. The three loci cooperate to the risk that is low in subjects carrying no homozygous genotype (O.R. 1.25) but it is very high (O.R. 13.240) in subjects carrying the three homozygous genotypes.
From a practical point of view, the study of ADA gene may help to detect obese subjects at high risk of T2D who need active preventive measures. The results point to the importance of further studies on the role of genetic variability within ADA gene on the relationship within obesity and T2D.
|An Unusual Case of Complex Regional Pain Syndrome
|George M. Weisz
The complex regional pain syndrome (CRPS) was reported in the literature following numerous traumatic events. Stretching the Brachial plexus, such as in peri-operational positioning, was as yet not found. The author is presenting a recently discovered such case. The clinical presentation is illustrated by a probable mechanism of pathogenesis.
|Perceptions and Expectations about Care in Hospitalized Patients over 75 Years of Age
|Alica Hanzeliková
|Francisco López-Muñoz
Objective: To know the expectations and perceptions of patients over 75 years of age, regarding the quality of care provided to acutely ill geriatric patients admitted to the Hospital Virgen del Valle de Toledo Spain.
Methods:Design: An observational, descriptive, cross-sectional study.
Location of study: Geriatric Hospital Virgen del Valle Toledo (Spain).
Subjects: Patients older than 75 years of age admitted to the Acute Treatment Unit at Hospital Virgen del Valle de Toledo.
Sample size: 267 patients (p = 0.5, confidence interval 95%, e = 0.06).
Measures: Validated questionnaire based on the SERVQUAL model to measure the expectations and perceptions of care.
Results: The global assessment of overall satisfaction with the attention and care they received was "moderately good". Higher scores were obtained in the assessment of "care" than in "attention received", in general. The results highlighted the importance of empathy and information. The theory suggesting that satisfaction with the nursing staff is a good predictor of overall satisfaction with the hospital has found support in this study.
Conclusion: There exists an urgent need, when it comes to caring for older people, to increase the level of knowledge about the patient's preferences along with understanding their expectations, in order to help develop better care. Knowledge of the deficiencies of care provides professionals with information indicating where they should intervene to make favourable changes with a resultant increase in patient satisfaction.
|A Left Temporal Arachnoid Cyst in a Patient with Early Onset Schizophrenia
|Yakup Albayrak
|Ece Altındağ
Arachnoid cysts are mostly asymptomatic and diagnosed incidentally. In the literature, some case studies report a probable etiological association between arachnoid cysts and psychiatric disorders. We report an early onset schizophrenia case who had a left temporal arachnoid cyst and who had an inadequate response to antipsychotic treatment. We discuss the potential association between arachnoid cysts and psychiatric disorders in the light of the literature.
|The Role of Serum Bio-Markers in Predicting Small Bowel Pathology in Crohn`s Disease Patients
|Anthea Brincat
|Neville Azzopardi
Background: Computed tomography enterography (CTE) is a useful modality in the evaluation of small bowel (SB) crohn`s disease (CD) as it can provide assessment of disease activity, extramural abnormalities and SB complications. This procedure however utilises radiation exposure. The aim of this retrospective study was to determine the clinical indications and findings on CTE and to determine if serum bio-markers (CRP, ESR, platelet count and anaemia) can predict significant pathologies.
|An Overview of the Genetic Causes of Frontotemporal Degeneration
|Wanda C. Reygaert
Many neurodegenerative diseases (NDDs) have been thought to be caused mainly by conditions that were not controlled by genetic inheritance. Extensive research into these diseases has recently discovered that perhaps a majority of them have genetic inheritance components. Once thought to be a rare form of NDD, frontotemporal degeneration (FTD) is now considered to be the main cause of early onset NDD, and the information on genetic causes and inheritance has increased dramatically over the last 10 years. The main genes that have been found to be involved in frontotemporal degeneration, MAPT, TARDBP, GRN C9orf72, VCP, FUS, and CHMP2B, have also been found in related diseases such as Alzheimer's disease, Amyotrophic Lateral Sclerosis, and Parkinson's disease. This paper is intended as an updated review of the genetic causes of FTD. This information should aid physicians and scientists in understanding the current concepts, and encourage even more genetic testing so that a full knowledge of genetic inheritance in FTD will be soon be forthcoming.
|Cutaneous Leishmaniasis: Report of Two Atypical Cases
|Reza M. Robati
|Fahimeh Abdollahimajd
Multiple and unusual clinical features of cutaneous leishmaniasis (CL) had been reported as hyperkeratotic, psoriasiform, eczematoid, zosteri form pattern, warty lesions, erysipeloid, and acneiform lesions. The clinical features of CL primarily depend on the host's cell-mediated response and the species of Leishmania being involved. In this paper we reported two cases of atypical CL from Iran, Shohada-e-Tajrish and Loghman-e-Hakim hospitals presented with infiltrative erythematous lesions covering the perioral region and the lower limb, respectively. The diagnosis of cutaneous leishmaniasis was confirmed with skin smears and biopsies.
|The Psychiatric Aspects of Alopecia Areata
|Gamze Erfan
|Yakup Albayrak
Alopecia areata (AA) refers to noncicatricial hair loss. It is defined as a secondary psychiatric disorder in the classification of psycho dermatological disorders. Its profound effect on a person's physical appearance and the resulting emotional stress have led many researchers to investigate psychiatric aspects of AA in recent decades [1, 2]. This study presents a review of the literature and highlights psychiatric aspects of AA. The results showed that both pediatric and adult patients with AA have a high risk of depression and anxiety. Dermatologists should consider a psychiatric evaluation of female patients under 20 years with AA to detect potential depression and anxiety. As much as alexithymia also in association of AA and other psychiatric disorders, such as schizophrenia, obsessive-compulsive disorder (OCD), personality, manic, bipolar, attention deficit, phobic disorders, further investigations are needed. The evaluation of the psychological status of patients with AA is extremely important to aid the well-being of individuals suffering from this disease.
|Clozapine use in Dual Diagnosis Patients
|Marta Marín-Mayor
|Jorge López-Álvarez
Background: Dual diagnosis (DD), defined as the co-occurrence of a substance use disorder (SUD) and a severe mental illness (SMI), is associated with several negative outcomes. Typical antipsychotics (TAP) are not of great value for patients with DD as they are associated with poorer responses and can worsen SUD. Atypical antipsychotics (AAP) offer several advantages compared to TAP and in DD patients they have been found to be effective in treating both, psychiatric symptoms and substance use. The aim of this article is to review the use of clozapine (CLO) for treating DD patients.
|Review of Mipomersen Sodium (Kynamro®) for Familial Hypercholesterolemia
|Lunawati L. Bennett
|Megan Chalk
Objective: To review the pharmacology and pharmacokinetics, and to evaluate the clinical efficacy, safety, and place in therapy of mipomersen sodium (Kynamro®) for the treatment of familial hypercholesterolemia (FH).
|Conventional and Advanced Ocular Formulation and Delivery: A Mini Review
|Lunawati L Bennett
Objective: To review available ocular formulation and delivery for the treatment of eye diseases, and to discuss the advantages and disadvantages of the ophthalmic formulation and delivery due to the complexity anatomical of the eye.
Data Sources: A literature search through Pub Med (1984 – December 2016) was performed using the key words: ocular barrier, posterior segment, anterior segment, disease of the eye, peptide delivery, ocular delivery, ophthalmic.
Study Selection and Data Extraction: Articles in English identified from reviews, abstracts, and presentations on eye formulation and delivery were included.
Conclusion: Effective treatment of ocular diseases has been difficult challenges due to the nature of the disease, the presence of the ocular barriers, and the unique structure of the eye. Within the last 2 decades, challenges in drug delivery have been partially met through modification of the ophthalmic formulations using viscosity enhancing polymers, hydrogels; through formulation of novel drugs approach using prodrugs, gene therapy and peptide delivery; and through making the drug particles smaller using nano-formulations techniques which all are aimed to increase the drug's retention time in the eye, to have the least side effects, and to be minimally invasive. However, there are many more challenges that need to be addressed including: the application from the research bench top using rabbit or cadaver into patients' specific diseases, decreasing the toxicities of the formulations, and making the ophthalmic formulations and deliveries safe, well-tolerated and cost efficient.
|Health Tourism in Clinics Located in Tourist Areas: the Case of Spain
|Jonay Perera-Gil
|Rodrigo Chacón-Ferrera
Objective: Knowing the characteristics of health tourism and to develop a theoretical framework exploring empirical evidence the health tourism in Spain studying major competitive methods, the aim is to objectively examine the lines of action being taken by the clinics to then offer a theory of how to compete successfully in the medical tourism business.
Method: Apply a descriptive quantitative approach to analyze data collected through a questionnaire distributed to 148 clinics in 50 provinces, in 2011.
Results: Tourist offers medical services are mainly aimed at German, British and French citizens. 91.46% of the centers surveyed say their services are designed for tourists. There are agreements with hotels / apartments according to 59.52% of the sample, stating that the 66.67% refuse to work with health tourism and wellness, which could offer service centers / clinics in the rest of Spain and abroad.
Conclusions: There is a high demand for health tourism. Tour operators play an important role in the management of these services, as well as in the design of travel packages and medical services adapted to the expectations and needs of tourists. The most popular services include: emergencies, plastic surgery, and clinical analyses.
It is noted that there is a strong presence of marketing and advertising around the sector, as well as efforts by hospitals to train employees to this section of business.
|Journal of Translational Proteomics Research (Volume 3) Combinational Synergy of Antibiotics and Antimicrobial Peptides
|Pramod Shah
|Chien-Sheng Chen
Combination of existing antibiotics have been introduced to increase the efficacy for a long time. Synergistic combinations of antibiotics are most desirable due to reduction of doses, toxicity and side effects of the individual antibiotic as well as prolonging in evolution of antibiotic resistance. Recently, antimicrobial peptides (AMPs) are gaining attention as viable alternatives to antibiotics due to the broad spectrum of activities and abundantly present in multicellular organisms that act against invading microbes. The combination of AMPs and conventional antibiotics enables to reduce the overall cost and widen the power of synergistic effects. Synergistic combinations are also reported among AMPs. Despite enormous advantages of synergistic combinations and several reports and uses in clinical medicine, only few underlying mechanisms are revealed. In this review, we overviewed the mechanisms of antimicrobial agents' synergistic combinations and introduced the proteome chip approach for predicting new synergistic combinations and deciphering the synergy mechanisms.
|Anti-DNA ("Cationic") and Ani-Histone ("Anionic") Auto-Antibodies: Two Sides of One Coin?
|Yuriy Kit
The mini review is focused on the analysis of published data and the results obtained by author with co-workers about biological activity of anti-DNA ("cationic") and anti-histone Н1 ("anionic") auto-antibodies linked with autoimmunity and oncology. The feathures of anti-DNA and-anti histone auto- antibodies, which might be engaged in regulation of tumor cell progressing, are considered.
|Loss of SYK and LYN Tyrosine Kinase Expression Impair Ponatinib-Induced Apoptosis in K562 Cells
|Valérie Lagarde
|François-Xavier Mahon
Targeting the tyrosine kinase activity of BCR-ABL is the gold standard strategy in Chronic Myeloid Leukemia (CML) for the last decade. Whereas inhibitors of BCR-ABL tyrosine kinase are now used in frontline therapy for CML, third generation inhibitors of BCR-ABL tyrosine kinase such as ponatinib has been developed for the treatment of BCR-ABL resistant mutants. In the current study, we generated K562 ponatinib resistant cells (KRPO) and investigated its mechanism of resistance. No over expression of BCR-ABL or multidrug resistance gene (MDR-1) were found among the investigated mechanisms as verapamil did not overcome resistance. Downregulated expression of both p72 SYK and p53/56 LYN kinases was found in ponatinib K562 resistant cell line. Albeit both mRNA and protein level were decreased in KRPO for SYK only protein level was downregulated for LYN suggesting a posttranscriptional mechanism. This mechanism of resistance also prevents imatinib, nilotinib or dasatinib-induced CML cells apoptosis.
|Head and Neck Squamous Cell Carcinoma (HNSCC) Protein Profiles Associated with Tumor Response to Treatment
|Bissan Ahmed
|Paul Debbage
Head and neck squamous cell carcinoma (HNSCC) remains one of the most aggressive malignancies, characterized by limited therapeutic success and poor outcome. Despite continuous development of novel therapeutic strategies, disease-free survival in patients with advanced HNSCC has not been improved during the last 30 years. Evidently, a deeper understanding is needed of the molecular mechanisms underlying both intrinsic and acquired HNSCC cell resistance to currently existing therapeutic approaches. Proteome analysis is a powerful method which can provide deep insight into the molecular basis underlying HNSCC cell survival despite cytotoxic anti-tumor treatment (chemo-, radiotherapy). Evaluation of the protein profiles of cells obtained from locally recurrent or metastatic tumors can allow researchers to identify key protein players which regulate the HNSCC response to therapy. Additionally, subcellular fractionation and isolation of various cell organelles followed by proteomic analysis can provide data about intracellular protein localization, translocation and function following anti-cancer therapy. This review article discusses the protein patterns in HNSCC cells responsible for the radio- and chemo-resistance of these tumors and which result in the carcinoma cell survival and HNSCC recurrence..
|MAPMAKER/EXP Version 3.0b: Though Used Since Time Immemorial Still Difficult for Beginners to Start with Map Construction for the Genetic Studies
|Rajinder Kaur
|Neha Sharma
With the advancement of molecular biology, interest in linkage map construction and QTL identification is growing among researchers day by day. Plant genome mapping and QTL analysis allows the identification of genes associated with economically important traits and the use of this information to further improve crops. So, we also attempted to construct a genetic linkage maps in our laboratory using more than one molecular marker systems and to analyze Quantitative Trait Loci (QTL) from the constructed linkage map. Every first time user finds many hurdles about the use of the software MAPMAKER. Though the problems were not very big but there was no one to tell us about the start of the software MAPMAKER and one by one commands to follow. So this article is written keeping in mind those beginners who are new to linkage map construction and QTL identification but it's their desire to find certain genes of interest in their test crop.
|A Retrospective Survey of the Incidence of Hypertension in Abia State-Nigeria
|S. Oladipo Gabriel
|A. Osunwoke Emeka
Hypertension is becoming more common as urbanization increases and this has been shown in several studies all over the world especially in Africa. This study was carried out to survey the incidence of hypertension in Abia State using Aba metropolis as the case study from 1995 - 2005, so as to make recommendations that would help modify life style of the people, thus helping to reduce the growing incidence of hypertension related complications such as stroke, heart failure, kidney failure, heart attack etc. It was a cross sectional study with data collected from four different hospitals in Aba, Abia State. The data was tabulated, compared and analyzed using percentage. From the result, it was observed that the incidence was higher in men than in women. Also, the incidence appeared to have dropped in 1995 and 1996. All other years recorded increased incidence with 2005 having the highest percentage. The total incidence and percentage incidence were worked out and represented in a bar chart. The result showed an increased incidence from 5.5% in 1995 to 14.7% in 2005, showing an increase of 9.2% over 11 years period, which amounts to an average increase of 0.8% annually. The incidence of Hypertension increases as the year goes by, hence the need for life style modification.
|Antibodies Possessing a Catalytic Activity (Natural Abzymes) at Norm and Pathology
|Severyn Myronovskij
|Yuriy Kit
The review is focused on the analysis of published data and the results obtained by the authors about the catalytic activity of antibodies (abzymes) at norm and pathology. Potential pathogenic and beneficial role of natural abzymes is discussed.
|CHIEF EDITOR: Ershov Bogdan Anatolievich, Doctor of Historical Sciences, Professor, Voronezh State
|Ashmarov Igor Anatolievich, Deputy Chief Editor, Candidate of Economic Sciences, Associate Professor
Journal "BULLETIN SOCIAL-ECONOMIC AND HUMANITARIAN RESEARCH" publishes articles about the relationship between different state institutions and society. The editorial Board determines the procedure for publication of articles.
The articles are reviewed and accepted only after at least two positive reviews of three reviewers.
The author retains the copyrights to his articles.
Journal is published four times a year, 1 time per quarter (№ 1 - January, February, March, № 2 - April, May, June, № 3 - July, August, September, № 4 - October, November, December).
Scientific direction:
The journal publishes articles in the following scientific areas:
|Mahmut SAĞIR
|Zekeriya ARSLAN
This research aims to identify the levels of problems that pre-school teachers have experienced
|Optimized Production Assessment, Compartmental Modeling and Dosimetric Evaluation of 177Lu- PSMA-617 for Clinical Trials
|Mehdi Sharifi
|Hassan Yousefnia
177Lu-PSMA-617 was prepared at the optimized conditions (95°C, 15-18 µg peptide, 35-40 min; solid phase purification) using 177Lu obtained from 176Lu(n, γ)177Lu reaction(>98%, ITLC, HPLC, S.A. 22-24 TBq/mM) followed by stability (up to 48 h), biodistribution studies (up to 168 h), planar imaging, compartmental modeling and dosimetry estimations via Sparks's extrapolation method in human organs. Kidney is the critical organ with the dose of 0.067 mGy/MBq and the radiopharmaceutical can be safely used in trials considering the human dose
|Bifid Pelvis Appearance and Yo-Yo Reflux on Dynamic Renal Scintigraphy: Two Case Reports
|Mine Araz
|Derya Cayir
Bifid (two-compound) renal pelvis constitutes 10% of normal renal pelvis. The Yo-Yo reflux is reflux from one ureter to another in incomplete ureteral duplications. The diagnosis of yo-yo reflux is difficult. Technetium-99m diethylenetriamine pentaacetic acid (Tc-99m DTPA) is used to evaluate renal function. We present two cases of bifid renal pelvis and yo-yo reflux with Tc-99m DTPA dynamic renal scintigraphy.
|Evaluation of Residual Thyroid Tissue with Tc-99m MIBI in Differential Thyroid Carcinoma Patients: A Case Report
|Derya Cayir
|Mine Araz
Tc-99m pertechnetate thyroid scintigraphy is used in the routine for the evaluation of residual tissue after total thyroidectomy operations in differentiating thyroid carcinoma. Tc-99m methoxy isobutyl isonitrile (Tc99m MIBI) was first developed as a myocardial perfusion agent and is also used for tumor imaging. Tc-99m MIBI is taken up by the functioning thyroid tissue and washed-out fast. We present a case of differentiated thyroid carcinoma where uptake out the thyroid bed was not detectable by Tc-99m pertechnetate thyroid scintigraphy but with Tc-99m MIBI scintigraphy in the postoperative period.
|Radioiodine Therapy of Benign Thyroid Diseases
|Derya Cayir
|Mine Araz
Radioiodine-131 (I-131) is used in treatment of benign thyroid diseases with hyperthyroidism; toxic diffuse goiter, toxic nodular goiter and toxic multinodular goiter for long years. Treatment success depends on various factors. The most important factor affecting the success of treatment is the susceptibility to target tissue I-131. This review aims to give information about the physical and biological characteristics of I-131, advantages and disadvantages, indications and contraindications for I-131 therapy, patient preperation and administiration of I-131, dose selection, precautions on possible side effects, evaluation of treatment response and make an overview on the clinical studies about I-131 therapy.
|Is Routine Diagnostic Radioiodine Whole-Body Scintigraphy Needed in Patients who Received Ablative doses of Radioiodine for Differentiated Thyroid Carcinoma?
|Cigdem Soydal
|Elgin Ozkan
Aim:The present large-series retrospective sought to assess DWBS findings 6‒12 weeks after RIAT in DTC patients in various risk groups. In addition, the study compared patients' simultaneous sTg levels.
Material and Methods:The follow-up data of 2879 patients who had received RIAT for DTC between 1998 and 2016 were evaluated for inclusion in the study. The study retrospectively evaluated the following: age at the time of diagnosis; gender; histopathological features of thyroidectomy materials (histological subtype, variant, dimension, multi-focality, thyroid capsule, and vascular invasion of tumors); TNM stage; ATA classification; sTg, suppressed-serum Tg, and antiTg antibody levels; and DWBS findings. Patients were categorized according to sTg level (undetectable, 1‒10 ng/ml, and >10 ng/ml). Then, the DWBS findings were analyzed according to sTg level.
Results: The study analyzed 2184 patients (1805 F, 379 M; mean age: 43.54±12.64). In 2077 (95%) patients, the DWBSs performed 6‒12 months after RIAT had shown no pathological uptake throughout the entire body. Pathological uptake had been detected in the neck and outside the neck in 88 (4%) and 19 (1%) patients, respectively. All patients who had had normal DWBSs also had had undetectable simultaneous sTg levels. In addition, the DWBSs had been normal in 187 (8%) patients who had had simultaneous sTg levels> 1 ng/ml and in 286 (13%) patients who had had levels > 10 ng/ml. In all patients who had pathological uptake in DWBSs, simultaneous sTg levels were > 1ng/ml, and in 47, they were> 10 ng/ml.
Conclusion: Routine DWBS seems to be unnecessary, even in high-risk DTCs. However, in patients who have detectable levels of serum sTg, it could be performed to localize the disease and plan patient management.
|Immunoscintigraphy for Therapy Decision Making and Follow-Up of Biological Therapies
|C. Lauri
|S. Auletta
With the availability of new biological therapies there is the need of more accurate diagnostic tools to non-invasively assess the presence of their targets. In this scenario nuclear medicine offers many radiopharmaceuticals for SPECT or PET imaging of many pathological conditions. The availability of monoclonal antibodies provides tools to target specific antigens involved in angiogenesis, cell cycle or modulation of the immune systems. The radiolabelling of such therapeutic mAbs is a promising method to evaluate the antigenic status of each cancer lesion or inflamed sites before starting the therapy. It may also allow to perform follow-up of such biological therapies. In the present review we provide an overview of the most studied radiolabelled antibodies for therapy decision making and follow-up of patients affected by cancer and other pathological conditions.
|Impact of 18F-FDG PET/CT for Detecting Primary Tumor Focus in Patients with Histopathologically Proven Metastasis
|Elgin Ozkan
|Cigdem Soydal
Purpose: To describe the impact of fluorine (18F) - fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in detecting primary tumor focus in our patient population who had histopathologically proven metastasis.
Methods:37 patients who underwent 18F-FDG PET/CT to detect primary tumor focus in our department were included in the study. The results of PET/CT and clinical follow-up data were reviewed retrospectively. PET/CT results were compared with histological analysis and/or clinical follow-up data.
Results:Primary site of malignancy was correctly identified by PET/CT in 16 patients (16/37, 43%). Lung was the most common detected site (7/16). The mean SUV of metastatic tumor was higher than that of primary tumor. False positive and false negative results were obtained in 2 patients, respectively. In the remaining patients (17/37; 46%) the primary tumor was not localized by PET/CT. According to these results, the sensitivity and specificity of PET/CT were calculated as 89% and 90%, respectively. However, PET/CT scan determined additional metastatic focus and therapy management was changed (9/37, 24%). The primary focus was established in 4 of 8 (50%) patients with metastatic cervical adenopathy and in 12 of 29 (41%) patients with extra cervical metastases.
Conclusions:18F-FDG PET/CT can detect the primary tumor focus in about half of all patients with histopathologically proven metastases. In the remaining patients, it may contribute to therapy management by identifying additional foci.
|Beta-Minus Emitters Dose Point Kernel Estimation Model Comprising Different Tissues for Nuclear Medicine Dosimetry Applications
|Pedro Pérez
|Federico Geser
The use of β-emitters for therapy purposes is one of the most extended procedures for tumor treatments in nuclear medicine practices over the last years. The constantly increasing dose delivery to healthy tissues in this practices, due to their high linear energy transfer and their radiobiological characteristics, might lead to complications in radiosensitive organs/tissues. Research efforts should be conducted to the development of tools and methods devoted to perform precise dosimetric calculations to deal with this issue and assess accurately dosimetric estimations on patients treated regions.
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Welcome to Billesdon Church of England Primary School
Well Done to the children who performed in the Snappy Opera at Neville Holt.
Head Teacher's Welcome
Welcome to our wonderful and friendly Church of England Primary School, providing
exemplary education for children aged 4 to 11 years old.
I am incredibly proud to have joined this vibrant and progressive school at such an exciting time. All the staff and children have made me feel very welcome and I feel privileged to be joining the Billesdon school community.
My priority as Head Teacher is to meet the needs of all our pupils to achieve their full potential in their academic, creative, personal, physical, moral and spiritual development. We are fortunate to have outstanding,
Within the context of Christian belief and practice, our school has developed a set of core values which will continue to underpin all the work we do. The strong Christian ethos throughout
These values will have a huge impact as your child develops. They help to deepen your child's positive values and in doing so, help them consider the implications of their choices in relation to themselves, the communities
I know how vital working in partnerships with parents really is, in order for children to find school a positive and rewarding experience. I strongly believe achievement and enjoyment go hand in hand to ensure each child's excellent progress. I hope you will support our high expectations in all areas, especially in behaviour and achievement
Mrs Louise Cook, Head Teacher
Rated as an outstanding church school by SIAMS in October 2014


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And that was when I realized I had found the perfect dress.
Hands down, this is a wonderfully written pattern that is so easy to follow, versatile and flattering while being so very comfortable.
I thought I would have a hard time using an online pattern, but the parts that needed to be printed were perfectly done, and the online directions were thorough and simple to understand. There were also a ton of photos and visuals and that helped me so much.
The pattern gives you all kinds of tips and explanations that taught me about how to use and work with knits.
Making a muslin is recommended. The thing, that in my ignorance, I didn't realize was that a muslin doesn't have to be muslin, but is a first draft of a dress. Don't use actual muslin, especially when it is a knit pattern (please don't ask for photos or any other explanation).
Next I learned that all stitches are not equal... there are different knit stitches on my machines and some of them worked better than others.
The pattern discusses all of this, but I still found it helpful to see how the different stitches worked with each fabric. Ironing also made a huge difference as well.
I found that my first thoughts weren't the best and I played around with the different stitches in different places. I found that the 'triple' stitch worked well for most seams while a narrow zigzag was great for the hem (green dress). The 'lightening bolt' stitch seemed to pucker more and didn't seem as strong (I used it in the purple dress)
I had a hard time finding knits I liked at the store, so I actually ordered some online from fabric.com. I was wary of ordering online, but was pleased at the options.
The ones I chose are 95% cotton with 5% lycra for stretch.
I was concerned they were too thin when they initially arrived as they are like a good t-shirt fabric, but they worked perfectly.
The pattern specifies fabrics, and using the categories to select fabric type and content along with stretch was very helpful in figuring out what would work for this dress.
Also remember to not get overly excited by new fabric,and make sure to wash it before sewing. Yes. fabric will shrink. Especially cottons. And when you cut a dress per the pattern and are taller than average at 5'8", chances are it could end up being a tad short.
I found this out when I excitedly completed the purple dress, tried it on and it fit well then I realized I had a deer in the headlights moment... I hadn't washed the fabric. It's short, but my husband calls it cute, so I'm just going with it.
I will also add that since losing weight I still have issues with wanting to make things larger than I probably need. I cut both dresses a size or 2 larger than what I measured, but the purple shrunk and is a better fit than the green for this reason. The green does have some extra fabric and 'bunching' under the arms which would have been eliminated if I had made it the correct size to begin with.
I'm definitely still learning, but this dress is very quick and seems like it will be a good addition to my wardrobe.
My daughter has also requested a couple of these as they are just easy to wear.
I'm also looking at making some with the longer and 3/4 length sleeve variations included in the pattern as well. It is just warm where I live and short sleeves are practical for a good 6-9 months, or so, of the year.
And since I realized I never seem to smile in photos, I tried to get some where I am more 'me'. I'm not photogenic as I seem to always be moving, but that's just me on a windy summer day in Georgia, and yes, I keep my piano on my front porch.


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Barry Jackson of the Miami Herald reports that the Dolphins have been doing a "lot of research" regarding Georgia RB Todd Gurley in recent weeks.
- According to Jackson, the Dolphins are "unquestionably intrigued" by Gurley.
Gurley is among the draft prospects in Indianapolis this weekend for medical rechecks, which makes sense given that he's coming off of a torn ACL.
The Dolphins have been linked to receivers and cornerbacks in round one, but depending on what happens with Michigan State's Trae Waynes and the top-three receiver prospects, there's a chance they could consider taking a running back.
Many draft experts view Gurley as the most talented running back in this year's draft class, but the injury concerns have opened the door for Wisconsin RB Melvin Gordon to possibly be the first running back to come off the board.
Last year, Gurley was suspended for four games after it was found that he accepted money for autographs. Upon returning to Georgia, Gurley unfortunately sustained the season-ending knee injury.
Gurley finished his college career with 3,285 rushing yards on 510 carries (6.4 YPC) to go along with 65 receptions for 615 yards receiving and 42 total touchdowns. He also contributed two kick return touchdowns as well.


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Today's Challenge is to write a letter to my parents....
Dear Mom and Dad -
Thank you.
For all that you have given me.
For all that you have done for me.
For guiding me in becoming the person that I am today.
For inspiring me.
For challenging me.
For picking me up and brushing me off when I have fallen.
For answering my questions, even the crazy and off the wall ones.
For asking me questions, so that I remember to come out of my shell.
For worrying about me.
For trusting me.
For NOT trusting me, at times.
For knowing "when I have learned my lesson".
For knowing when I still needed more education.
For being the best examples of humanity.
For showing me what love is supposed to be and what true, eternal friendship looks like.
For supporting me in any hair-brained scheme I may have and then for not saying "I told you so" when they perhaps failed.
For pushing me when you knew that it was for my own good to keep me focused on what needed to be done and not quit
For backing off when you understood that I was not necessarily on the right path for me and needed to quit.
For not making me feel guilty when I do quit, or stupid when I change my mind.
For tolerating me when I was going through my spoiled teen years.
For sheltering me from some of the struggles and turmoil that the world around us experienced.
For all the hugs and kisses.
For the spankings and groundings.
For limiting the television that was watched and introducing me to the magic of a book.
For living in "the country" so that I could grow up being a kid with a great imagination.
As I write this, I am getting teary-eyed thinking about how wonderful it has been to have you as my parents. True, there have been the rough patches where I struggled to either spread my wings when I wasn't quite ready to fly or when you were ready for me to leave the nest, but I was a little too comfortable snuggled into it. I sometimes wonder if our family is weird in that we aren't in constant contact with one another, and yet, I'm pretty happy with the state that our relationship is in. Even if we don't speak, I think about you and worry about you daily.
I love you more than I can ever show you.


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Please, let me introduce you to Apollo:
Apollo is the worst cat on planet earth. Seriously. Let me explain.
I adopted Apollo when he was eight weeks old. His mother was a feral cat who had given birth and then been killed. Someone found the kittens and nursed them back to health. I was nineteen, a sophomore in college and home on summer break. My cat Pepper died in June, and by August, I felt like I was ready to love again, so I went to the local SPCA and brought home a two-pound bundle of joy.
For the first two weeks, Apollo did everything with me. He rode in my car, he went to visit friends, he hung out with me at the barn, he slept in by bed, everything. Then, I, well, I went back to college – in North Carolina.
About two weeks after I went back to school, I got a disturbing phone call from my dad.
"I think your cat got into something. He's got dirt all over his face, and I'm scrubbing and scrubbing, but it won't come off."
"Dad, seriously? His color is changing! His sun spots are coming in!" That's what I like to call his black spots – get it? Apollo, god of the sun?
"Oh! Well, that explains why it isn't coming off then! Thanks!"
"How is he doing? Does he miss me?"
"Uh…I don't know, he's a cat. Do cats miss people?"
"Gee, thanks."
That was the last positive conversation I can remember having about Apollo.
From there, things began to spiral downward. Apollo was a maniac. He jumped on every counter, knocked down every object he could find, climbed the curtains, ate the plants, tried to ride the dog, bit and scratched everyone, and he liked to play this fun game called "Feed the Puggle" where he would get onto the counters and into the cabinets and knock down everything that was edible and then sit on the counter and watch Kahlua (who has dietary restrictions due to his weight) eat it.
From what I understand, my dad and stepmom tried everything they could think of to call a "cease and desist" order on these behaviors. They tried squirt bottles, brooms, rolled up newspapers. I remember two particular instances that were over the top. My dad specially designed rat traps that would hurt but not break anything (he tested them on himself first) and placed them on every surface Apollo ever dared to travel (even going so far as to tie them into the plants he liked to chew). Another time, I came home on break and found a pellet gun propped up against the living room table.
"Dad, are you using that on the cat?"
He grinned and raised his hands, "What? I only pump it up once."
I, for my part, did try some alternative methods. For example, I tried a specialty collar with some natural chemicals in it to calm him down. I tried treats loaded with tryptophan. I tried sedatives. I even tried overfeeding him, hoping the extra weight would calm him down.
Nothing, and I mean nothing, worked. The cat was absolutely fearless. He did not care about what pain he suffered going through the motions of being bad, he was just going to be keep being bad. I actually asked the vet it if was possible for him to have that disease that people get where you don't feel pain. As it turns out, Apollo does not have this disease, nor had my vet ever heard of a cat having it.
Then I met Joe, we moved in together, adopted Smokey and voila! No more Apollo problem! NOT.
The straw that broke the camel's back was when my stepmom spent most of her day baking a cake for a friend. When she turned her back for an instant, up went Apollo and down went the cake.
I got a call at work, then a text, "You come get this cat. Tonight."
So…Apollo came to live with us. Mostly, he stays in the basement, and he continues to wreak havoc. He and the dogs get along and even play, but Joe can't stand him. He gets up on Joe's work bench and knocks tools and cans and jars full of screws onto the floor. Once, he knocked a box of Joe's childhood photos off the shelf and ripped them apart. I thought I was going to lose my family that day.
Recently, I feel like I've been talking a lot about clicker training my dogs, especially clicker training desired behavior in and undesired behavior out. I have also been saying that I wish I knew about clicker training when I was training horses, and that the great thing about clicker training is that it lends itself to every species of animal.
But I haven't been practicing what I am preaching, because Apollo is still the worst cat in the world. So I made a resolution: By God, I am going to clicker train that damn cat.
Last night was lesson one. And you know what? He did all right. I had him standing on a box (his empty litter container actually) in less than 10 minutes. Okay, so he's not exactly the best cat in the world yet, but I'd say he's on his well to at least being tolerable.
Mission accomplished.


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By Joshua Partlow
"If anyone takes down this body, he will meet the same fate. This is a warning to the Taliban."
It was not clear whether the army or angry residents had strung up the corpse. But the point was unmistakable: A favorite Taliban intimidation tactic has been adopted by the Islamist militia's opponents, reflecting the desire of at least some here in the Swat Valley and neighboring areas to ensure that the Taliban, now officially gone after a fierce fight, stay away.
A caravan of trucks and buses carrying hundreds of war refugees passed by the dangling man Monday on its slow procession to Swat. After fleeing the Pakistani military's war with the Taliban and spending weeks away from their homes, the returning refugees were met by politicians throwing fistfuls of petals.
The politicians spoke of battles won and peace restored. But this did not feel like a particularly joyful day. None of the returning refugees could be sure exactly what they were coming home to. The valley has changed hands several times between the Taliban and the government in recent years. Residents remain fearful that the Taliban will be back, and they have little faith that the government will protect them.
"I hope God will make it safe," Bacha Zada, a baker, shouted from atop a truck crossing into Swat. "This is our new life."
For two months, soldiers and insurgents have fought amid the rice paddies and apple orchards of this verdant valley. The fighting forced more than 2 million people out of what was once a tourist destination and into crowded tents and relatives' homes in adjacent areas of
Ahead of these returnees, a convoy of provincial politicians and their armed guards toured the valley, driving into Mingora, the area's largest city and the scene of some of the worst urban combat. Although most of the villages and towns in Swat seemed largely intact, albeit deserted, evidence of a battle here was plain to see.
Bombs and artillery shells have demolished houses and turned schools and police stations into rubble. There are fire-blackened storefronts and roll-down shop gates crumpled like foil. Around
"This is our main city," said Khalil ur-Rahman, a leading politician in Mingora. The Taliban "have destroyed everything.," he said.
It was at the center of the square that Taliban fighters used to dump their victims' bodies when they controlled Mingora. These gruesome killings initially occurred on Thursday evenings, Rahman said, but then became nightly affairs. Eventually, the area was dubbed
"They gradually got stronger. They were given support because there was no opposition. The people used to think the army and the Taliban were friends, brothers," he said. "Then they began slaughtering the people, police, public officials."
The government has renamed the square, calling it
On Monday, flak-vested soldiers and black-clad police officers stood guard throughout the abandoned valley. They have converted schools and offices into garrisons and blocked roads with logs, rocks and sandbags to slow potential suicide bombers, although no traffic circulated other than the patrolling military pickup trucks and armored vehicles.
Swat is still under curfew, so virtually all shops and offices remained closed. The few residents who chose to stay through the fighting carried white flags as they walked cautiously through the streets.
Shah Dawran, a surgeon, left his home during the fighting but stayed in the valley to keep working. With no insulin available, he concocted a homemade remedy to treat a diabetic. He took in patients with shrapnel and gunshot wounds and saved the ones he could. "Two people died due to huge blood loss in my presence," he said.
Military officials said that more than 1,500 suspected Taliban fighters were killed in the operation, although just one of the top 27 Taliban commanders in the area is confirmed as dead. The army has said that Maulana Fazlullah, the leading Taliban commander, known for his fiery radio sermons, has been injured. Taliban spokesmen have denied that.
Encouraged by the improved security, authorities say Swat is secure enough for families to return home.
"Peace will soon be restored," said Muhammad Idrees Khan, police chief of the Malakand district, which includes the
The main challenge for the government involves restoring services, rebuilding the damaged structures and protecting villagers as they come home in a phased return expected to unfold over the coming weeks. One brigadier general who briefed the politicians said police morale remained a critical concern. When the Taliban took control of the area, the police put up little resistance. A new, 2,500-strong police force built around retired military officers is scheduled to begin work soon to bolster the ranks.
The security forces must also attempt to gain the trust of the returning families. The brigadier general said he asked a group of people for clues about who destroyed a school in Swat, but nobody offered any help.
"Now we are trying to have people take us into their confidence," he said.
Many displaced farmers were forced to abandon their crops before the summer harvest and are now worried that they would have difficulty providing for themselves. A minister for
"We will try to focus on the problems of the people," he said. "It is not 100 percent clear, but I am satisfied with the situation."
By the late afternoon, the first buses finally crossed into Swat. Television cameramen crowded around the first vehicle and shouted questions at the passengers, who said they were relieved to be going home. Then the bus driver pushed through a crowd and drove under a white banner that read: "Welcome to your own homes."
Special correspondent Haq Nawaz Khan contributed to this report.


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Sunday, March 16, 2008
We got to talk to our little man
Well, we got to talk to Michael briefly this afternoon. The connection was horrible. We could see him, but the audio was very broken up. He could not see us and the audio was very broken up. So I guess we wait for two weeks and hope for a better connection next time. He is getting so big. It breaks my heart to see how big he is and how much of his life we are missing. I also keep thinking about how hard it is going to be for him when he has to leave everything and everybody that he knows to come live with us. Please pray that the Lord would prepare him for this huge transition in his life.
Posted by Family by Love at 3:26 PM
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