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Overall Myla has been doing great! She was able to get up yesterday around 5 in the evening. Her first attempt, she yelled "ow" but like the doctor said if you let her on her terms she will most likely be more willing. About 30 minutes after the doctor left, sure enough she wanted me to hold her and for the first time in 48 hours-a rough 48 hours-I was able to hold my sweet baby!
I was so overjoyed to have this precious moment. You may wonder why Myla never has on a gown, well, the long and short is she hates them! Any time we could get one on her in PICU, when she would wake up, the first thing she would do is rip it off and anything else she could find. Many attempts at the heart monitors, pulse ox, and IV. That is why she has on the little white and yellow splint-to keep her other hand from pulling IV out.
She then went for a wagon ride to the playroom down the hall. Although there weren't a lot of smiles, I know she was glad to get out of her room. Especially since her siblings, Daddy, and Aunt Angie were with her!Well, the fun went down hill from there and it really had nothing to do with her back or getting her up. She was very tired and I think she has had bouts of itching from her pain medication. She had one last night and ordered Benadryl-but it took forever to get up to the floor. She ate pretty good, but then had some bizzare blister on her tongue. An hour and a half later she calmed down and went into a good deep sleep. Thankfully the night time sleep was very good with only two interuptions and she went back to sleep withing 20 minutes of the nurses leaving.
Thank everyone one of you for praying. We have truly felt God's hand through all of this. Myla is surprising us every day as her recovery has been great. Her surgery was shorter than expected, her incision is shorter than expected, and we will probably go home on the earlier end of our estimation! The issues we have been dealing with haven't had much to do with her back!! The other issues have been unexpected but what 2 year old or even 40 year old likes needles in their hands and feet, or to feel like they are itching to death! She is such a trooper!


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The muscles of the foot
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Keywords: 3d medical illustration, anatomy, ankle, ankle muscles, ankle musculature, ankle tendons, back view, black background, calcaneal tendon, close-up view, colour, foot, foot muscles, foot musculature, human, illustration, muscles, muscles of the ankle, muscles of the foot, musculature, peroneus brevis tendon, peroneus longus tendon, portrait, side view, stylised, tendon, tendons of the ankle, tibialis posterior tendon, with skeleton
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subset: commoncrawl


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He realised that his reps have been shelling out 70% in their day leaving voicemails that could go unanswered and the rest was invested updating a complex, homebaked CRM program. Mark understood their current approach was stifling the business enterprise' progress so in January of 2016, he transitioned Top rated Echelon on to The brand new, user friendly HubSpot CRM.
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Indicators on case study solution You Should Know
He realised that his reps have been shelling out 70% in their day leaving voicemails that could go unanswered and the rest was invested updating a complex, homebaked CRM program. Mark understood their current approach was stifling the business enterprise' progress so in January of 2016, he transitioned Top rated Echelon on to The brand new, user friendly HubSpot CRM.


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Nick Clegg will be launching his campaign in Sheffield on Friday according to press reports.
Great news! Now let the contest begin!
Go, Nick, go!
Wednesday, 17 October 2007
Nick Clegg To Formally Put His Hat in the Ring
Posted by Toby Philpott at 20:58
3 comments:
The best candidate by a mile
- 17 October 2007 at 22:16
- Allan said...
Blair mark three
Cameron mark two
Just another man in a suit
We need a woman
- 17 October 2007 at 23:10
- Toby Philpott said...
The insults against Nick are in poor taste Allan. I wouldn't back him if I thought he was either a Blair Mark 3 or a Cameron Mark 2.
What's wrong with wearing suits anyway?
- 17 October 2007 at 23:14
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|All the hard work is done for tour participants, from unloading the canoes to getting us fitted with life jackets!
|The Rio Grande was tranquil the day of our tour...
making for a relaxing trip.
|All the gear is provided!
|Our guide, John, of Big Bend River Tours
They took us by van to our departure point, the La Cuesta River Access of Big Bend Ranch State Park. Because the river level was down, we were going to enjoy a gentle float down the Rio Grande by canoe. Had we taken our adventure a few weeks earlier--just after Mexico released water into the river--we would have traveled by raft through rapids! But, today called for a leisurely, relaxing kind of "take your time" adventure the exemplifies the Big Bend. And we were up for that!
Every need was accommodated; all the equipment provided, even shade umbrellas if we wanted them! All we had to do was relax and enjoy the water and the steep cliffs of the Rio Grande.
We watched shorebirds scratch at the pebbly riverbank, turtles catching a few rays, butterflies, tiny lizards, dragonflies, and a squirrel scampering up the canyon wall.
Tomorrow, we continue our adventure on the river as part of our one day, Saddle/Paddle tour!


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Tim Burton's The Nightmare Before Christmas MonopolyGame
Tim Burton's The Nightmare Before Christmas Monopoly
139 loyalty points
eParcel delivery $7.50 Australia wide
Relive the cult classic Nightmare Before Christmas as you buy, sell and trade iconic movie locations such as Jack's Tower, Oogie Boogie's Casino, and Sally's Alley. This completely customized game features film photography and six collectible pewter tokens.
• Custom designed game board and box top art
• 6 collectible pewter tokens: Jack's Skull, Sally, Oogie Boogie, Evil Teddy, Zombie Duck, Mayor's Hearse
• 22 popular locations are represented by imagery from the movie
• Two Ways to Play: Traditional Monopoly game play or 60-minute speed play option
• "Chance" and "Community Chest" cards transformed into "Halloween Presents" and "Christmas Presents" cards
• 1 x Game Board
• 6 x Collectible Tokens
• 2 x Dice
• 16 x Christmas Presents Cards
• 16 x Halloween Presents Cards
• 32 x Houses Renamed Toys
• 12 x Hotels REnamed Assembly Lines
• 28 x Title Deed Cards
• 1 x Pack of Jack Skillington Monopoly Money
• 1 x Rule Sheet
Ages: 8 years +
When you place an order with the ABC Shop Online you will receive an immediate confirmation email prior to your order being processed. We will notify you again by email once your account has been charged and your order has been dispatched.
|Delivery Time
|Australia Post eParcel within Australia
|~2 to 7 days
|Australia Post Express eParcel within Australia
|~1 to 3 days
|Standard Delivery
|Express Delivery
|Traceable service with Australia Post eParcel service. Your unique online tracking number will be sent to a valid email address. If you choose Authority to Leave your parcel will be left in a safe place on your premises, or else a card will be left for you to collect the parcel from your Post Office.
|~ 2-7 business days*
|~ 1-3 business days**
Please note that the delivery times given are from time of dispatch from our Fulfilment Centre, which usually takes 1-2 business days as long as all of the items ordered are listed as 'Ready to deliver'. We are happy to split orders based on availability, however this will incur an additional freight charge.
|Order Weight
|DHL Globalmail Packet Plus
|Calculated in Checkout
|under 2kg
|~ 3-14 business days
(subject to availability)
|DHL International Parcel Standard
|Calculated in Checkout
|2kg to 20kg
|~ 3-14 business days
(subject to availability)
Important information about International shipments
International Courier orders are traceable and fully insured and therefore replaceable if lost en route. The ABC Shop will provide as much assistance as possible in tracing misdirected items but cannot be held responsible for items lost by overseas postal services.
While Australian tax (G.S.T.) is removed from all international orders please be aware that your order may be subject to local Customs duties and/or local taxes in the country of destination. Please check with your local authority to ascertain applicable rates. Any additional charge must be borne by the recipient.
International Orders - Additional Identification
Some international orders may require additional identification before being processed. The transmission of this information to the ABC Shop may affect estimated delivery times. The ABC Shop reserves the right to request additional identification prior to processing orders originating outside Australia.
Customs and International Duty
International delivery may be subject to local Customs levies. Please check with your local authority to ascertain applicable rates. Additional charges must be borne by the purchaser.
*Large and Bulky Orders
Some large orders and bulky items may require an adjustment to quoted delivery costs. We will contact you to approve any additional charges that may be incurred, and you may cancel your order at any time prior to processing.
Unforeseen supply problems or unexpected demand may occasionally result in stock being unavailable. Should there be a delay in dispatching your order we will contact you advising you of the reason for the delay. You may cancel such an order at any time prior to processing.
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I've piles of picture books. Yes, even in the RV! Then even more picture books via Epic Books for Kids and I have even more on my wish list. (Golly I miss our old library and the ability to just go pick them up whenever.) But between home-keeping, lessons, chapter books and everything else we just have not been getting to them. Or the kids just choose the same ones over and over again to read.
Then I introduced Books & Blankets. Each week I fill one of our baskets with about 14 books from our shelf and those are our books for that week. Each child gets to choose a book from the basket and them mama gets to choose a story as well. That is FOUR picture books every other day! That doesn't even count books we read for one on one time or the Read to Me books from Epic. Or story time with daddy, he used this basket for their choices over the week too. Or poetry and literature we read for Poetry Tea Time.
Keeping the books in the basket limited to one week encourages them to choose new books that they might not have noticed on the shelf and by keeping them in the basket allows them to be reread at any of our Books & Blanket times. I'm attempting to NOT purchase anymore picture books until we have read all the ones we have at least twice.
My husband is pretty happy about that cost saving goal. And I love that it means that anyone can do this without any extra cost. Even if their picture book collection is smaller then mine they can use the books from their library to create the same basket for the week.
Oh my gosh, we are reading SO many books! I love it!
Okay, so when its Books & Blankets time the kids each grab a blanket and they either lay back and listen, sit close and snuggle or play quietly while I read. I mix up the order I read each book chosen depending on the mood of the kids. Generally I find it best to start with the youngest or my book choice but each day is different. Then over the course of the rest of the day we will chat about the stories as they come up naturally or with gentle leading on my part.
I've spoken to this before but this Slow Loop rhythm is creating so much peace in our days and fostering the sweetest memories. It's delightful that even after one short week that the kids are so excited about if it is Poetry Tea Time day or Books & Blankets day and are planning accordingly. And keeping mama accountable to the schedule too.
I don't receive any compensation from Epic, I just love it and would love it even if I had regular library access.


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Ash Wednesday is the start of the Lenten journey of 40 weekdays (Monday through Saturday) that takes the church to the eve of Easter. We had our service at St. Andrews UMC on the 17th of February. We had a time of scripture reading, singing, a short lesson, and communion. This year is unique in that Ash Wednesday had Communion and Easter falls on the first Sunday of April and we will also have Communion. Now, I don't know about you, but for me bookending Lent with Communion is a special gift. This is going to be a very interesting Lenten season.
Sundays celebrate the resurrection of Jesus, therefore, the six Sundays that occur during Lent are not counted as part of the 40 days of Lent, and are referred to as the Sundays in Lent. The number 40 is connected with many biblical events, but especially with the forty days Jesus spent in the wilderness preparing for His ministry by facing the temptations that could lead him to abandon his mission and calling. This season of the year is equal only to the Season of Advent in importance in the Christian year, and is part of the second major grouping of Christian festivals and sacred time that includes Holy Week, Easter, and Pentecost.
The color used in the sanctuary for most of Lent is purple, red violet, or dark violet . These colors symbolize both the pain and suffering leading up to the crucifixion of Jesus as well as the suffering of humanity and the world under sin. Purple is also the color of royalty, and so anticipates through the suffering and death of Jesus the coming resurrection and hope of newness that will be celebrated in the Resurrection on Easter Sunday.
Lent has traditionally been marked by penitential prayer, fasting, and almsgiving. Christian churches that observe Lent focus on it as a time of prayer, especially penance, repenting for failures and sin as a way to focus on the need for God's grace. It is really a preparation to celebrate Easter, and the resurrected life that Christians live and hope for.
Many modern Protestants consider the observation of Lent to be a choice, rather than an obligation. They may decide to give up a favorite food or drink (e.g. chocolate, alcohol) or activity (e.g. going to the movies, playing video games) for Lent, or they may instead decide to take on a Lenten discipline such as devotions, volunteering for charity work, and so forth.
In addition to the service we passed out Lenten devotionals supplied by the Society of Saint Andrew. http://www.endhunger.org/ We used these last year and they were very well received and used by the churches. I encouraged everyone to use this as a preparation during Lent. I have found that I have such a busy life that if I don't use all the resources that I can find to prepare my heart before Easter or Christmas, I get to that special day carrying the load of my daily life and missing what God had for me. I'm sure I'm not the only one who experiences this. So I encourage you to do whatever you can to prepare yourself for what God has prepared for you this Lenten season.


text: Back to search results Production Operators New Location Kingfield, Maine Job type Contract/Temp to Hire Salary $16.00/Hour Our Client in Kingfield, ME is seeking Production Operators. Candidates should feel comfortable meeting goals daily in a warehouse environment. The Production Operators are hired initially as temporary positions with a 6-month contract and the opportunity to convert to permanent positions. Duties may include, but will not be limited to: Inspect raw materials against quality standards before loading Maintain work area in an organized and clean manner ensuring safety and good manufacturing practices are met Promotes a positive attitude and energy Work as a team with other Operators to ensure no line stoppages and improve operations Cross training to perform work on other lines or in other production areas as needed Ability to move/lift 50lbs various times over a 12hr shift, basic math and reading skills Other tasks as required Additional Requirements: Candidates should be flexible enough to work either 6am-6pm or 6pm-6am Willingness to work holidays and weekends as our Customer is a 24/7 business operating through most weekends and holidays $16.00 per hour Ability to successfully complete an online skills assessment prior to onsite interview Willingness and ability to work in a facility with minimal temperature control, exposed to local temperature variations (hot & cold) Adecco provides one of the most comprehensive benefit packages in the industry to Contract employees. Click Apply Now, call 207-782-2882 or text 857-293-9211 to be considered for the role and a Recruiter will contact you shortly. More Information Share


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In our country we have a thriving range of burger chains, pizza chains, kebab shops, chicken joints and countless more. Yet all we ever hear are constant warnings and advice telling us to avoid these things, that Britain is getting too fat, and that we should all be grazing on salad and vegetables. Every time I open a newspaper it is the same old advice, re-packaged over and over again. Recommendations to only eat processed meat such as sausages, salami etc, once a week and then you are only allowed one slice. Any more than that and you're almost certainly to die a grisly death by the end of the month.
A search of books on the subject generally reveals similar results - there seem to be hundreds of books out there telling us how to eat more healthily and lose weight.
Yet obviously none of this advice is working or is being ignored as the nation's waistlines are still increasing. I think the Government and all the rest of the do-gooders are totally missing a trick by endlessly lecturing us about what we should and shouldn't be eating. It gives all of these foodstuffs an element of naughtiness, a kind of "forbidden fruit" you could say. What they seem to not realise is that people don't generally like being told what to do, and will generally do the complete opposite, so the more they tell us to eat healthily, the fatter we get. No wonder we are all sneaking down to the fridge at quarter past midnight every night when everyone has gone to bed to scoff down an enormous clandestine slice of gala pie. Or maybe that's just me.
I think it is time for a new approach, and when my book comes out it will be a refreshing change for all those millions of people out there who actually enjoy their food and don't want to be made to feel guilty every time they gaze longingly as the sausage rolls and pork pies on the deli counter in the supermarket. It seems there is not a single book out there extolling the virtues of all these fine foods, but you are quite safe reading this with me! Go on - ignore the food miseries! Allow yourself that pork pie - why not? You've earned it! Life it to be enjoyed. You won't get any lectures here. Stick with me, it's safe and comfortable here and you can have whatever you want. I won't judge you. In fact I might even join you for a bacon bap if you're offering - in fact I am even willing to sign your bap if you ask nicely x
Now if the Government followed my advice and told us all to eat these foods, I think there would be a collective weight loss! Make salad the villain instead - then people who want to be naughty can eat that instead! Forgive me if I don't join you, I've got an aversion to chlorophyll.
Getting back on topic, I don't want to become typecast as "The Sausage Man". You would think from some of the newspaper and magazine articles recently that it was all I ever ate. Maybe I will end up having to accept it and embrace it in the same way that Leonard Nimoy will always be "Spock", however, I feel I owe it you, my legion of food loving fans to embrace the whole portfolio of foods and outlets available, therefore we shall be exploring all manner of other foods and where to buy them in the weeks and months that lie ahead.
So come with me if you will, in to Bicester town centre, where great things are afoot. If you a local you may well be aware that I run a facebook page called "Bicester Town Centre Chat". Now whilst this may appear that I am providing a nice community area for people to discuss local happenings, it is in fact merely a front for my own evil ends. In addition to the standard crazed "world domination" plans, "Dr Evil" style, it also gives me a great opportunity to steer the conversation around to all things fast food at every opportunity and convince my rapidly growing empire of followers that Bicester will never be truly happy until the entire town centre is wall to wall eating establishments. Our little group, which is becoming a big group, is so huge that it is now attracting attention from national chains who are beating down the doors to come here. Whilst rumours of Greggs and others abound, we have for certain arriving next month an American style diner and a Nando's. In order to drum up interest in Nando's I decided to run a little competition on the group where I offered a paperback copy of my book "Austerity Dad" worth £9.99 for the person who could come up with the most amusing reason why they were looking forward to Nando's coming to town.
|Coming to Bicester on 27th November!
NB: When I say my book is "worth" £9.99, that is in fact how much it costs. Not being so egotistical that I believe that the entire world thinks my books are the funniest things ever invented since sliced bread (which in itself is not that funny), I did offer a cash equivalent prize to the winner of "1p" for people with no sense of humour.
I was also going to run a second competition for a free date with me at the aforemtioned "Deans Diner" but when one of the group members suggested I could offer a second prize of "two dates with me" I decided better of it.
So what is Nando's like? I did go to one once in Oxford years ago, my own personal perception was that it was a bit of a posh KFC, I guess we shall find out when it opens. So it's time to filter through some of the entries and see what people have to say: All the entries were great but I don't have time to analyse them all so I have picked five favourites as our final nominees:
Hayley Collier: I am looking forward to NANDOS coming to bicester because.........
I have never been to one plus I have the urge to go dressed as a chicken lol xx
That will definitely be worth seeing, Hayley!
Wendi Woo: I'm looking forward to Nando's coming to Bicester because it will be one less shop unit for Costa Coffee to inhabit!
Excellent entry, Wendi clears knows my feelings on Costa, now that is how to do well in a competition, get to know the judges. NB: I don't mean getting to know the judges like that, no such offers were forthcoming (see below).
Emma Lou Cowell: I'm looking forwards to Nando's coming to Bicester because I've never eaten in one before and when I'm driving past the one in Oxford and I like the look of the cock in their window.
A cock in a window, what more could a girl ask for?
Laura Wyllie: I'm looking forward to nandos coming to Bicester so that Jason can do a smoking hot interview in newspaper, without holding his sausages
I may have to borrow Hayley's chicken outfit for the interview, Laura!
Sarah Hewitt: I am looking forward to Nandos coming to Bicester because it opens just in time for my birthday :0) love love love their piri piri seasoned chips and their chicken is 100 xs better than KFC!!!
I love KFC so if their chicken is 100x better I am not sure if my body will be able to withstand the pleasure!
Just before I announce the winner I would like to point out that none of the competitors offered me any sort of cash bribe or to sleep with me in order to win. Clearly I am not abusing my position of power strongly enough and will have to try harder next time.
And the winner is...Hayley Collier! I shall see you outside Nando's on 27th November dressed in your chicken costume, to present you with your prize!
I also went into town and interviewed a few prominent local residents outside Nando's to see what they had to say which provided some interesting responses.
Local crime-fighting superhero, Captain Chubbchaser had the following to say: "I'm really looking forward to Nando's coming to town, this is going to have a real beneficial effect on the town's wasistlines. There's far too many skinny people around here, especially the girls. Look at that one over there, practically skin and bone. She can't be more than 12 stone,. Women of Bicester - come down here and fill up and who knows, I might return the favour".
Eccentric throwback to Roman Times, Bloaticus, said "I can't wait to get into Nando's and I am going to buy everything on the menu. Then I am going to sit in the middle of a long table and throw all of my chicken bones over my shoulder and anyone who does not like it I'll send to the Colosseum".
Reclusive millionaire "Lord Bicester", on a rare outing to purchase some venison from Sainsbury's said "No I shall not be going into such a frightful place. All of my poultry is hand reared on the thighs of a virgin you know. Well that would be if I could find any in Bicester. I'm having to settle for importing Yang Sizhong chickens these days. I don't know what the world is coming to. In fact I am going straight home to write a letter to the Daily Telegraph about it".
So that about rounds up my preview of Nando's which is opening on the 27th November. I hope to see you there for a live report! And if anyone from Nando's is reading, you could do a lot worse than hire me to be your special celebrity guest to open the new outlet! Who better than a well known local celebrity writer who has published two books as well as being featured in countless newspapers, magazines and on radio shows over the past few months for my culinary exploits! Don't just take my word for it, just type "Jason Ayres Sausage Taster" into Google and you can learn all about me! I shall draw you plenty of publicity - please feel free to PM me on facebook and we can discuss my fee.
If you have enjoyed reading this blog, please take a look at my books on Amazon (Paperback & Kindle), where you can read lots more of the same! Click here.
Until next time, food lovers


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I am a lucky boy, what with Jof helping me to get dressed and feeding me strawberries and jammy croissants for breakfast, in between laundering and stuff.
Today at school we had the Year 6 Fashion Show. A catwalk was erected in the assembly hall and they had designed their own T-shirts and they strutted with various degrees of tush-shaking skill. I liked the guy who did a headstand with leg scissors and pushed off into a breakdance move. But because of my fatal injury, I was not allowed out at breaktime and had to stay inside playing wordsearch and a game on the laptop where you're a red face bouncing over a blue landscape and you have to eat people, how many times have we all had that dream.
I brought home my Roman Chariot which closely resembles a frontiersman's waggon. It was a lovely day but as I can't really go to the park we had to paint the house-for-rent. So we walked there and the JBs said hello out of their car window because they seem to spend their life in a traffic jam outside our house.
Then I sat on the wall of my old school while he ran back to get the house keys, FML. He painted Bedrooms 1 and 3 while I sat on the stairs and played Minecraft and dealt with our first 3 cold callers who looked like they were selling religious double-glazing.
But it wasn't long until I was playing Intergalactic Thermonuclear Warfare with the broom and the mop again so we went home, carrying the ladder so we could get my scout camping equipment down out of our own loft. I sat outside the Co-op (had to buy milk) guarding the ladder and said 'Sup Laydeez to the passing girlies because you just know they like a bit o' rough and then we went home and I played Minecraft shoot'em up. Supper was deep-sea worms with pepperoni.


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Tuesday, August 16, 2011
A Post for #GoatPosse
What do you call your panties/underwear/undergarments? Do you have any commonly used nicknames for them?
** Honestly, I don't really think of them by any name other than "laundry," because I do the laundry in the house and they are always in the wash. Or coming out of the wash, at which point they must be put away.
However, I do have a four-year-old who potty-trained not all that long ago, so there's a LOT of discussion about "underpants."
Have you ever had that supposedly common dream of being in a crowded place in only your underwear?
** I have not. I rarely remember my dreams, and when I do, they are always related to the end of the world. This is why I write horror, I guess. (Feel free to check out my books. You can find them over there -> )
What is the worst thing you can think of to make panties out of?
** Jalapeno peppers.
If you were a pair of panties, what color would you be, and WHY?
** Black. I'm utilitarian, not pretty.
Have you ever thrown your panties/underwear at a rock star or other celebrity? If so, which one(s)? If not, which one(s) WOULD you throw your panties/underwear at, given the opportunity?
** I'm going to go with no, and more importantly, is that something guys do? I can't see it as a fannish-type thing that most women would enjoy. I can't imagine going to an Aimee Mann concert, tossing my underthings onstage, and having it end in a way that doesn't involve Aimee calling security.
You're out of clean panties. What do you do?
** I'm a dude who only wears men's clothing. So really, I'm always out of panties. If you're looking for what would happen if I was out of underwear, I'm going to say, "Wash some." Did I mention I do the laundry in the house?
Are you old enough to remember Underoos? If so, did you have any? Which ones?
** I am. And oddly, I recall my brother having/wearing Superman underoos, but I can't recall wearing it myself. I probably did.
If you could have any message printed on your panties, what would it be?
** Once again, do men really have things written on their underwear? I suppose some do. I had a friend who had a matching tie and boxer set. That was always good for a chuckle whenever I saw him wearing the tie.
Sitting here trying to think of an answer, I came up with about two dozen somewhat-naughty ideas, but I'm pretty sure they'd be ineffective as far as my wife went, so... I'm going to have to pass on this one.
How many bloggers does it take to put panties on a goat?
** Are they sort of sickly and weak like me? Because in that case, like 10. Also, what size is this goat? Because if it's like a newborn goat, I could probably do it on my own.
Tag Four People and tell them why you are being so cruel to them.
I have no one to tag, really, because I think everyone in #teamgoat did this one already...
8 comments:
HEE! Welcome to the #goatposse!ReplyDelete
Welcome to the mayhem of the #goatposse! I'm not on twitter as much now because I'm working my real job, but they keep me posted on all the goat meetings and head butting classes. You'll have to see Michelle for your mandatory pair of sparkly goat pants. Anita passes out the head-butting helmets on Thursdays. :) (See what I mean)ReplyDelete
Thanks ladies. I shall try to always be an asset to the #goatposse.ReplyDelete
Woohoo! Welcome to #goatposse, Josh. And well done. It's very nice to bleat you. HEE.ReplyDelete
I'm so thrilled we have another male team player. If you'd like to see Justin's panty meme, he guest posted over at my blog here: http://authoraghoward.blogspot.com/2011/08/wearing-panties-just-isnt-scary.html. Kalen hasn't done his yet, but he's been suffering #goatpeerpressure.
Watch your tweets. You will be getting a head butting helmet very soon. :)
- AnonymousSeptember 29, 2011 at 7:26 AM
OMG! HAHAHAHA! Your answer to the worst thing to make panties out of may be the best one yet. Jalapeno Peppers! EEEEEK!ReplyDelete
Well done, my friend, well done. And welcome to the goatposse.
Welcome to the #goatposse!! We're an interesting bunch, to say the least. :-) and I second the hoooooolycrapouch of the jalapeño pepper panties lol.ReplyDelete
This is way overdue, but WELCOME TO THE POSSE! Well managed for a guy ;)ReplyDelete
Thanks everyone! Man, you guys are fun...ReplyDelete


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Ian Parrott: Tributes to Aberystwyth University professor
Tributes have been paid to an awarding-winning composer and eminent professor who has died, aged 96.
Emeritus professor Ian Parrott was born in London, but lectured at Aberystwyth University from 1950 until his retirement in 1983.
He was described as having a "brilliant musical intellect", while it is said his teaching style left a lasting impression on generations of students.
He was a student of the Royal College of Music and New College, Oxford.
He later served in World War II and time spent in Egypt inspired his symphonic impression Luxor, which won the Philharmonic Society first prize in 1949.
He joined the university a year later and became the Gregynog Chair of Music, a position he held for 33 years.
One of his former students and director of music at Aberystwyth University, Dr David Russell Hulme, said: "He became immersed in the musical life of his adopted country, and helped found the Guild for the Promotion of Welsh Music.
"Wales inspired many of his works, such as the overture Seithenin, the seascape Arfordir Ceredigion, written for the 1992 National Eisteddfod at Aberystwyth, and the operas The Black Ram and The Lady of Flowers."
His work included five symphonies, four operas and chamber works, often written for leading international artists.
He also wrote numerous books on music, and was a vice president of the Elgar Society and the Peter Warlock Society and received the John Edwards Memorial Award for devotion to Welsh Music and the Glyndwr Award for his outstanding contribution to the arts in Wales.
"His brilliant musical intellect and idiosyncratic teaching style left a lasting impression on generations of music students, many of whom rose to the top of the profession," added Dr Russell Hulme.
'Tireless work'
Aberystwyth University vice-chancellor Prof April McMahon said the university owed Prof Parrott an enormous debt of gratitude.
"Colleagues have spoken of the enormous contribution he made during his 33 year tenure of the Gregynog Chair of Music here at Aberystwyth, his tireless work after retirement and his unfailingly generous support and enthusiasm," she said.
Prof Parrott's funeral takes place in Llanbadarn, Aberystwyth, on Wednesday.


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I was asked to blog about the sites, tools, zines, lists, magazines, fundraisers and other resources I've found and continue to find when helping start-ups, job seekers, people with disabilities, older adults, nonprofits, etc. Read, Share, Save, Enjoy!
Monday, March 14, 2011
I don't know if I'd call FORA a rival for TED or a siblilng. It's the site that makes my brain smile and where I'm always in my happy place. You can watch lectures from renowned speakers,techies, filmmakers, educators, foreign leaders, and authors. The best description is NPR meets TED. Sometimes I don't agree with what's said, but it's said in an intellectual, researched way and I can respect that.
Labels: information, podcast, TED, webcast
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New Doodle Pattern
5 months ago
Thanks for posting my giveaway! Good luck!
What a great blog you have! I love your spooky porch from last year! I can't believe it's about that time again!
I know...we have been getting rain and already folks are burning wood in their stoves...I do love a good fire though..but not in August...take care...ReplyDelete
I don't want to brag
or make anybody jealous or anything,
but I can still fit into the earrings
I wore in high school.


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Wednesday, February 11, 2009
Higher Education Funding
Just a quick note, but if you have time, check out President Adams' testimony to the house higher education subcommittee from yesterday. It offers a fascinating summary of the challenges faced by institutions of higher education and the steps they are taking to deal with them. It is amazing how much money UGA has to raise on its own to run our flagship university.
2 comments:
- Ezra said...
- This comment has been removed by the author.
- February 12, 2009 at 9:44 AM
- Ezra said...
UGA pulled in $128 million in research grants for 2008. (Link is a PDF)
I'm not sure what the instruction and public service categories specifically mean. It would be good for it to explain the categories. :)
- February 12, 2009 at 9:45 AM
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text:
Save the Date: Austin Food and Wine Festival 2016
Tickets are selling fast for this popular swinging food festival in the Texan cultural capital. Take a look at this year's tempting line-up.Find out more
NYC Beer Week 2016 Kicks Off
Beer lovers will have an exciting line-up of events to tempt them across the city in this 10 day festival bringing out the barrels.Find out more
USA Artisanal Cheese Festivals in March
Cheese lovers will have the chance to sample locally produced cheeses at one of two festivals on the west coast next month. See what's on.Find out more
All Star Chef Classic Comes To L.A, March 9 -12, 2016
Prepare for this annual multi sensory culinary event with a difference, held inside a kitchen stadium with some of the world's leading chefs.Find out more
Save the Date: Taste of Dubai 2016
From 10 - 12 March Dubai will welcome top international chefs and foodies for three food fueled days of fun and entertainment.Find out more
Three Unmissable Food Events in Australia 2016
Melbourne and Sydney form Oz's foodie epicenter this spring with Redzepi's MAD symposium, Taste of Sydney and the Melbourne Food & Wine Festival.Find out more


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Released: 27th August 2010
Format: Xbox 360, PS3, PC
Developer: 2K Czech
Publisher: 2K Games
Another one of my hugely anticipated titles of the year is 2K Czech's Mafia II. Reams of game play footage has been shown to date of the game and every time another developer diary turns up, I get more and more excited to see what I believe has the potential to be game of the year. Now I know that without playing the game, it's incredibly hard to tell the impact such release will have, but the very fact that the developer is confident enough to provide hands-on time with the game months in advance of actual release date ought to be congratulated- this comes at a time when secrecy and the 'behind closed doors' approach is often the norm.
What has me most excited by the game is its setting- influenced by American cities of the time (mainly New York City and San Francisco), Mafia II is set in the fictional 'Empire Bay' of 1940s-50s era. Screen shots and footage show incredible periodic artistic designs and a frankly tremendous effort in capturing every tiny detail no matter how seemingly insignificant, from its soundtrack to shop fronts. The graphics look superb, both in terms of the look of the city, the ominous locations and facial animation that is captured perfectly in the trailer here.
The game centres on the Sicilian Vito Scaletta, returning home from his duties to the army during World War II. What follows is a spiral towards the life of crime and gangster undertakings. In an interview with 'GamesRadar', writer and director of the game- Daniel Vavra, explains his intent on "delivering a polished, story-driven experience, that makes gamers feel as though they are living a day in the life of a mobster". Comparisons are obviously easy to draw with such crime epics as Francis Ford Coppola's The Godfather and Scorsese's Goodfellas (which is in fact referenced in the announcement trailer for the game). A sweeping epic narrative is likely to be delivered succinctly and efficiently, with over two hours of cut-scenes (all rendered in-engine and real-time) featured within the game and what is said to be over 500 pages of screenplay! The cast of characters also look to be shaping up well, with a philosophy to characterisation that seems to be taken from the very best games of its type, ensuring characters are established well and with personality throughout the plot.
2K Czech have revealed their intent on delivering a truly living and breathing city which feels alive to the player. Game play videos are keen to show off the city in all its glory- a brief drive through the streets in period vehicles (that are said to feel heavy without being too overbearing), sees people going about their daily lives in exacting detail that can be seen in every aspect of Mafia II's implementation. It's really brilliant to see the game in action, and I urge you to search for some of the videos available because I haven't seen anything as stunning in the look and feel of a city in any other game, not even GTA IV's Liberty City. Couple that with the fact that the area is 10 square miles large (twice the area of the first game), featuring over 20 unique neighbourhoods and 50 intricately designed period vehicles filling its streets and the sheer scope of 2K Czech's daunting workload is still nigh on possible to comprehend.
Guns from the first game, such as the 'Thompson M1928', the 'Colt 1911' and the pump-action shotgun all return, along with WW II-era inspired weapons. Melee combat is a simple two-button affair, with 'finishing moves' a combination of the two, resulting in context sensitive finishes. For example, if you're stood in front of a car, Vito might smash his head into the hood to end the fight. Cover mechanics are used for gun-play with any environmental items available to hide behind, although making sure you're still protected as the physics engine does its work is key. Yes, cover is destructible and will no doubt force wary players straight into the heat of battle. The check point system from the first game is also said to be completely overhauled.
All in all, I simply can not wait for the game. The triple-A polish that seems to be shining from the every surface of the game is really great to see at such an early stage, and I expect a deep and thoroughly entertaining ride once I get hands-on with the game, 27th August 2010. You'd do well to keep an eye on this, too. It's going to be special!


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Marcia Brady: Coke fiend
The periodical of record (that would be People Magazine) says that Maureen McCormick, who played Marcia Brady and thus informed millions of boys what their ideal mate would look and act like, was bulimic after the show ended in 1974. It wasn't long before she found a better way to keep her weight under control, though. That would be a cocaine habit.
What's more unbelievable? The cocaine, or the fact that her husband had never seen an episode of The Brady Bunch before they started dating?
This has all come to light after her appearance on the upcoming edition of Celebrity Fit Club, in which she tried to drop 30 pounds.
I have unfortunately been unable to find you a fat picture of Marcia Brady. So this picture with her cute-but-no-Marcia daughter will have to do.
Labels: Celebrities


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WASHINGTON — Problems with the complex technology being installed in the new destroyers of the Zumwalt class have forced the Navy and shipbuilder General Dynamics Bath Iron Works to delay delivery of the first two ships, the US Navy said Monday night.
The Zumwalt (DDG 1000) had been scheduled to be delivered to the Navy this summer, but that has dropped back to November. Delivery of the second ship, Michael Monsoor (DDG 1001), production of which is about a year behind Zumwalt, has also been pushed back a few months in 2016, to November of that year.
Work on the third and last ship in the class, Lyndon B. Johnson (DDG 1002), has not been affected, and that ship is still scheduled for delivery in December 2018.
"The schedule delay is due primarily to the challenges encountered with completing installation, integration and testing of the highly unique, leading edge technology designed into this first-of-class warship," Cmdr. Thurraya Kent, spokeswoman for the Navy's acquisition directorate, said in a statement.
The three ships are all under construction at GD's shipyard in Bath, Maine. Zumwalt was launched last October and is 94 percent complete, Kent said, and the ship is expected to begin engineering sea trials later this year. Monsoor is scheduled for launch this year as well.
Bath also builds Aegis destroyers of the DDG 51 Arleigh Burke class. Completion delays with Zumwalt and Monsoor could affect Aegis destroyer production, Kent indicated.
Source:: Oceans


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yesterday i went to buy some fresh bean curds at the public market near our house. it's already 7:00 am in the morning and as usual the market was already teeming with people. vendors and buyers alike were all very alive. haggling over prices and then of course there were the usual debates over the quality of the goods. even i tried hard to haggle over the price of the bean curd. the girl vendor offered them at 3 pieces per 10 pesos. i informed her i was able to get them at 7 pieces for 20 pesos the other day. the girl displayed a disbelieving face. she smiled and told me the price has always been 3-for-10. i argued i always buy here at the same marketplace. finally, we agreed that if i buy 40 pesos worth then she'll give me an extra piece. so i happily walked away with thirteen pieces of fresh bean curd squares. these will see me through a week's meals.
i was walking past the market security outpost when i overheard this announcement by a lady officer. she was speaking through a bullhorn and her voiced boomed loud enough to soar above the proverbial marketplace noise and the street traffic.
"ATTENTION! EVERYONE!" she announced, "ANYONE WHO HAS LOST A CHILD? WE HAVE HERE A LITTLE BOY AT THE OUTPOST! HE IS ABOUT 4 YEARS OLD, SHORT CROPPED HAIR, WEARING BLUE SHORTS,WHITE T-SHIRT AND BLUE SLIPPERS. HE DOES NOT TALK MUCH. IF THE KID'S PARENTS ARE HERE NOW KINDLY COME HERE AT THE OUTPOST. HE'S BEEN HERE SINCE 4:00 AM.!"
wow! i said to myself. it's 7:30 now so the boy's been separated from his parents for more than three hours. it's amazing that they have not returned immediately to pick him up. i went near the outpost to catch a glimpse of him. his eyes were a bit puffy and reddened obviously from so much crying. he's quiet now, busy munching a piece of bread and sipping soda that the lady guards gave him. their description of him was perfect except that he looked very untidy. his white tee was really not white because it bore dirt and grime, his blue shorts were very dirty as well, and it's assured he had not changed clothes for some days. it appeared he really needs some good scrubbing.
my mind got disturbed looking at him. i lingered by the outpost for a while. the lady officer's voice boomed over the bullhorn again announcing this lost child. the lady officers waited. the child waited. i waited. our eyes were eagerly scanning all directions. we were all in prayerful anticipation.
no one came to claim him.
the little boy pursed his lips. he was about to cry again. it's been thirty minutes since i stood by the outpost.
i turned around and walked towards the direction of my home. i'll be home soon.
i don't know about the little boy. i just hope someone will come get him. i've read a lot of stories of children getting abandoned by impoverished, irresponsible parents. life is really disturbing.
at a distance as i walked, i once more heard the lady's voice over the bullhorn. well, the day's still early. the boy's been at the outpost for just about four hours. his parents might just be looking at the wrong place. they will come soon.
i hope.
Wednesday, November 30, 2011
life disturbing
Posted by sito saguid at 4:14 PM
3 comments:
- Bani Malhotra said...
=( hope the boy safely meets his parents soon...
- sito saguid said...
bani, i actually inquired about this when i had the chance to visit the marketplace and the lady guards at the outpost vaguely remembered the boy. i don't know if this was just indifference on their part or if this kind of incident, children getting lost in the marketplace, is somewhat a commonplace event that they have become accustomed to this. i was assured though that somebody came to pick him up.
- Bani Malhotra said...
that's great news that you followed it up and the boy reached his parents! =)
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Signs of a Drunk Driver
Despite increased awareness of its dangers, thousands of people each year make the irresponsible decision to get behind the wheel after drinking, endangering both their own lives and the lives of others. Depending on the driver's BAC level, the severity with which their motor functions and driving ability are affected can vary. However, any person who drives while impaired can cause a tragic accident. For this reason, it is important to be able to recognize the warning signs of a drunk driver.
At Habush Habush & Rottier S.C., our Lake Geneva auto accident attorneys make it their priority to fight for the compensation that is owed to those who have been injured by reckless drunk drivers. Contact our dedicated team of legal professionals today at 800-242-2874.
How to Tell if Another Driver is Intoxicated
Not all drunk drivers display the same signs, but it is likely that a driver is intoxicated if the exhibit one or more of the following signs:
- Weaving between lanes
- Speeding up and slowing down excessively
- Stopping inappropriately
- Driving without the proper lights on
- Making abrupt turns and movements with their car
- Driving the on the wrong side of the road
A driver who makes the careless decision to get behind the wheel while impaired should be held responsible for their decisions and the consequences that result from their actions.
Contact Us
The damages which you may suffer in the aftermath of a drunk driving accident can be devastating and debilitating. Contact the experienced Lake Geneva car accident lawyers of Habush Habush & Rottier S.C. at 800-242-2874 to discuss how we can help you today.


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Natural Products
|The herbs of Scutellaria baicalensis Georgi.
|Biological Activity or Inhibitors:
|1. Wogonoside has anti-inflammatory, anti-angiogenic and anticancer effects, it may exert its anti-inflammatory effect via dual inhibition of NF-κB and NLRP3 inflammasome.
2. Wogonoside markedly inhibits histamine release in cells stimulated with calcium ionophore A23187 or compound 48/80 and markedly inhibits LTB 4 production at the concentration of 100 uM.
3. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction, and that it might have a therapeutic potential for the diseases associated with the development of both inflammation and progress.
4. Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in acute myeloid leukemia (AML) cells, it may represent a therapeutic candidate for the treatment of AML.
5. Wogonoside partially inhibits MDA-MB-231 cell growth by inducing autophagy through the MAPK-mTOR pathway and may be a promising anti-tumor agent.
6. Wogonoside inhibits thrombin-catalyzed fibrin polymerization and platelet aggregation, it also elicits anticoagulant effects in mice, it possesses antithrombotic activities and offers a basis for development of a novel anticoagulant.
7. Wogonoside exhibits a protective effect on LPS-induced acute lung injury (ALI) via suppression of TLR4-mediated NF-κB signaling pathways.
|DMSO, Pyridine, Methanol, Ethanol, etc.
|Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.com
|After receiving:
|The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
|1 mg
|5 mg
|10 mg
|20 mg
|25 mg
|1 mM
|2.1721 mL
|10.8604 mL
|21.7207 mL
|43.4414 mL
|54.3018 mL
|5 mM
|0.4344 mL
|2.1721 mL
|4.3441 mL
|8.6883 mL
|10.8604 mL
|10 mM
|0.2172 mL
|1.086 mL
|2.1721 mL
|4.3441 mL
|5.4302 mL
|50 mM
|0.0434 mL
|0.2172 mL
|0.4344 mL
|0.8688 mL
|1.086 mL
|100 mM
|0.0217 mL
|0.1086 mL
|0.2172 mL
|0.4344 mL
|0.543 mL
|Citation [1]
Biochem Pharmacol. 2015 Mar 15;94(2):142-54.
|Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation.[Pubmed: 25677765]
|Previous studies have demonstrated that Wogonoside, the glucuronide metabolite of wogonin, has anti-inflammatory, anti-angiogenic and anticancer effects. However, the anti-inflammatory mechanism of Wogonoside has not been fully elucidated. Recently, NLRP3 inflammasome has been reported to be correlated with inflammatory bowel disease for its ability to induce IL-1β release. Nevertheless, there are few drug candidates targeting NLRP3 inflammasome for this disease. In this study, we investigated the anti-inflammatory effect of Wogonoside in dextran sulfate sodium (DSS)-induced murine colitis and further revealed the underlying mechanisms by targeting NF-κB and NLRP3 inflammasome. Wogonoside treatment dose-dependently attenuated DSS-induced body weight loss and colon length shortening. Moreover, Wogonoside prevented DSS-induced colonic pathological damage, remarkably inhibited inflammatory cells infiltration and significantly decreased myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) activities. The production of pro-inflammatory mediators in serum and colon was also significantly reduced by Wogonoside. The underlying mechanisms for the protective effect of Wogonoside in DSS-induced colitis may be attributed to its inhibition on NF-κB and NLRP3 inflammasome activation in colons. Furthermore, Wogonoside markedly decreased production of IL-1β, TNF-α and IL-6 and suppressed mRNA expression of pro-IL-1β and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-κB and NLRP3 inflammasome. In conclusion, our study demonstrated that Wogonoside may exert its anti-inflammatory effect via dual inhibition of NF-κB and NLRP3 inflammasome, suggesting that Wogonoside might be a potential effective drug for inflammatory bowel diseases.
|Citation [2]
Toxicology. 2009 May 2;259(1-2):10-7.
|Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction.[Pubmed: 19428938 ]
|Wogonoside, one flavonoid derived from the root of Scutellaria baicalensis Georgi, has been reported for its anti-inflammation activity; however, whether it can inhibit inflammation-induced angiogenesis is still unclear. In the present study, we evaluated the effect of Wogonoside on lipopolysaccharide (LPS)-induced angiogenesis in vitro and in vivo. Wogonoside suppressed the LPS-stimulated migration and tube formation of human umbilical vein endothelial cells (HUVECs), as well as microvessel sprouting from rat aortic rings in vitro. Moreover, Wogonoside also inhibited LPS-stimulated vessel growth of Chicken chorioallantoic membrane (CAM) in vivo. The mechanism revealed that Wogonoside inhibited LPS-induced toll-like receptor 4 (TLR4) up-regulation and its downstream mitogen-activated protein kinases (MAPKs) activation, by decreasing the phosphorylation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase. The results suggest that Wogonoside inhibits LPS-induced angiogenesis both in vitro and in vivo, and that it might have a therapeutic potential for the diseases associated with the development of both inflammation and angiogenesis progress.
|Citation [3]
Blood. 2013 May 2;121(18):3682-91.
|Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells.[Pubmed: 23487022 ]
|Wogonoside is the main flavonoid component derived from the root of Scutellaria baicalensis Georgi. It is a popular Chinese herbal medicine with the potential to treat hematologic malignancies. In this study, we investigated the anticancer effects of Wogonoside in acute myeloid leukemia (AML) cell lines and primary patient-derived AML cells. Wogonoside exerted antiproliferative properties both in vitro and in vivo. Furthermore, it efficiently inhibited the proliferation of U937 and HL-60 cells through the induction of G1 phase arrest and the promotion of differentiation. We also demonstrated that Wogonoside significantly increased the transcription of phospholipid scramblase 1 (PLSCR1) due to its influence on the expression of cell cycle- and differentiation-related genes, including the upregulation of p21waf1/cip1 and downregulation of the oncogenic protein c-Myc. Wogonoside also promoted PLSCR1 trafficking into the nucleus and facilitated its binding to the inositol 1,4,5-trisphosphate receptor 1 (IP3R1) promoter, thus increasing the expression of IP3R1. Finally, inhibition of PLSCR1 expression with small interfering RNA partially blocked Wogonoside-induced cell cycle arrest and differentiation and disturbed the Wogonoside-associated molecular events. The results of this study therefore suggest that Wogonoside may represent a therapeutic candidate for the treatment of AML.
|Citation [4]
Inflammation. 2014 Dec;37(6):2006-12.
|Wogonoside ameliorates lipopolysaccharide-induced acute lung injury in mice.[Pubmed: 24854163]
|Wogonoside has been reported to have anti-inflammatory properties. In this study, we evaluated the effect of Wogonoside on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Male BALB/c mice with ALI, induced by intranasal instillation of LPS, were treated with Wogonoside 1 h prior to LPS exposure. Mice treated with LPS alone showed significantly increased TNF-α, IL-6, and IL-1β levels in the bronchoalveolar lavage fluid (BALF). When pretreated with Wogonoside, the TNF-α, IL-6, and IL-1β levels were significantly decreased. Meanwhile, Wogonoside significantly inhibited LPS-induced increases in the macrophage and neutrophil infiltration of lung tissues and markedly attenuated myeloperoxidase activity. Furthermore, Wogonoside inhibited the TLR4 expression and the phosphorylation of NF-κB p65, and IκB induced by LPS. In conclusion, our results indicate that Wogonoside exhibits a protective effect on LPS-induced ALI via suppression of TLR4-mediated NF-κB signaling pathways.
|Citation [5]
Food Chem Toxicol. 2013 Jan;51:53-60.
|Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway.[Pubmed: 23000445 ]
|Previous studies have demonstrated that Wogonoside, a bioactive flavonoid extracted from the root of Scutellaria baicalensis Gerogi, has anti-inflammatory and anti-angiogenic activities. In this study, we evaluated Wogonoside-induced autophagy on human breast MDA-MB-231 cells. We report that Wogonoside triggered the formation of microtubule-associated protein-light chain 3 (MAP-LC3) positive autophagosomes and the accumulation of acidic vesicular and autolysosomes in MDA-MB-231 cells. In addition, cells treated by Wogonoside developed autophagosome-like characteristics, including single and double membrane vacuoles containing intact and degraded cellular debris. The results showed that Wogonoside promotes the expression of LC3-II and Beclin-1. Furthermore, Wogonoside inhibited cell growth of MDA-MB-231 cells in a concentration- and time-dependent manner, which was associated with Wogonoside-induced autophagy. Wogonoside also suppressed the activation of mammalian target of rapamycin (mTOR) and p70-S6 kinase (p70S6K) by regulating the expression of the extracellular signal-regulated kinase (ERK1/2) and p38 involved mitogen-activated protein kinase (MAPK) signaling pathway. Taken together, these results suggest that Wogonoside partially inhibits MDA-MB-231 cell growth by inducing autophagy through the MAPK-mTOR pathway and may be a promising anti-tumor agent.
|Citation [6]
Fitoterapia. 2014 Oct;98:27-35.
|Antithrombotic activities of wogonin and wogonoside via inhibiting platelet aggregation.[Pubmed: 25020199 ]
|Wogonin (WGN), a flavonoid extracted from Scutellaria baicalensis Georgi, has several biological effects including antioxidant, anti-inflammatory, antiviral, neuroprotective, anxiolytic, and anticancer activities, and the flavonoid Wogonoside (WGNS) can be derived from S. baicalensis, as it is a metabolite of wogonin. Here, the anticoagulant activities of WGN(S) were examined by monitoring activated partial thromboplastin time (aPTT), prothrombin time (PT), and the activities of thrombin (factor IIa, FIIa) and activated factor X (FXa), and the effects of WGN(S) on expression of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were evaluated in tumor necrosis factor (TNF)-α activated human umbilical vein endothelial cells (HUVECs). Treatment with WGN(S) resulted in prolonged aPTT and PT and inhibition of the activities of thrombin and FXa, as well as inhibited production of thrombin and FXa in HUVECs. In addition, WGN(S) inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation. WGN(S) also elicited anticoagulant effects in mice. In addition, treatment with WGN(S) resulted in significant reduction of the PAI-1 to t-PA ratio. Collectively, WGN(S) possesses antithrombotic activities and offers a basis for development of a novel anticoagulant.
|Citation [7]
J Ethnopharmacol. 2003 Jan;84(1):23-9.
|Effects of wogonin, wogonoside, and 3,5,7,2',6'-pentahydroxyflavone on chemical mediator production in peritoneal exduate cells and immunoglobulin E of rat mesenteric lymph node lymphocytes.[Pubmed: 12499072]
|Wogonin (WG), Wogonoside (WGS), and 3,5,7,2',6'-pentahydroxyl flavanone (PHF) were isolated from Scutellaria baicalensis, and their effects on histamine, leukotriene B(4) (LTB(4)), and immunoglobulin E (IgE) were examined in rats, observing for a manifestation of a type I allergic reaction. WG and WGS in the amounts of 10 and 100 microM were shown to markedly inhibit histamine release in cells stimulated with calcium ionophore A23187 or compound 48/80. PHF exerted inhibitory activity only at 100 microM. In the case of LTB(4), WG, WGS and PHF markedly inhibited LTB(4) production at the concentration of 100 microM. We also find that the increase in the IgE content induced by concanavalin A (ConA) was alleviated in the presence WG and WGS, while the inhibitory effect of PHF was much weaker. However, the magnitude of inhibitory effect observed on the content of lipid peroxidation induced by ConA was in order of PHF > WG > WGS, with PHF being the strongest. Interestingly, WG and WGS with the methoxyl group strongly inhibited histamine and IgE production, whereas PHF with the hydroxyl group in the B ring was much stronger than WG and WGS against lipid peroxidation. Based on data, it was concluded that the flavonoid components, WG, WGS, and PHF, may block a common pathway for the release of histamine and LTB(4), and that the IgE level is responsible for the lipid peroxidation induced by ConA.


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My car smells like a jam factory and my skin feels permeated with the scent of strawberries. I did fruit tasting platters on my event stalls and I reek of cherries and plums. I think I've converted the local populace into devotees of lychees and chinese gooseberries as well as extolling the virtues of blueberries.
I am so tired though I think I'll sleep for England tonight.
Tomorrow my health walkers will be mostly eating fruit too!
REVIEW: The Gaucho's Lady by Genevieve Turner
2 hours ago


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The Excellence in Graduate Student Mentoring Award (EGSMA) is given on an annual basis, to a member of the UB Graduate Faculty.
The nomination and selection process for EGSMA will occur during the fall semester of each academic year. The Graduate School will also submit the winner as UB's sole allowable nominee for that academic year's "Geoffrey Marshall Mentoring Award" which is administered by the Northeastern Association of Graduate Schools (NAGS) every spring.
The nomination period for 2017-2018 is now closed.
The Graduate School is pleased to announce the winners of the Graduate School's 2017-2018 Excellence in Graduate Student Mentoring Award:
Dr. Paul Gollnick, Professor, Department of Biological Sciences and Dr. Sargur Srihari, SUNY Distinguished Professor, Department of Computer Science and Engineering and Founding Director, Center of Excellence for Document Analysis Recognition (CEDAR).
Read more about the Excellence in Graduate Student Mentoring Award winners.
The criteria for EGSMA is as follows: Truly outstanding and sustained support and development of graduate students from course completion through research and subsequent career placement. This may be evidenced by providing sound advice with respect to an appropriate course of graduate study and associated course selection; encouraging and facilitating the best possible performance from students; generous giving of time or other measures of mentoring efforts; assisting unlikely or superficially unpromising students through to successful degree completion and subsequent career placement; advising and other assistance regarding the quality and quantity of student papers or other forms of publication and performance; and extraordinary efforts and success with student placements. These criteria are not meant to be exhaustive, but instead to suggest activities that might be demonstrated in a nomination package.
Only those individuals who are currently members of the UB Graduate Faculty and have held faculty appointment at UB for at least five years are eligible to be nominated. Each year's award winner will be chosen by a selection committee comprised of faculty appointed by the dean of the Graduate School. The winner will be publicly recognized at UB's annual Celebration of Faculty and Staff Excellence Ceremony.
We are pleased to announce that the winners of the Graduate School's Excellence in Graduate Student Mentoring Award for 2016-2017 are:


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PHOENIXProject ID: 28703
Fostering the rebirth of social sciences and humanities in the Central Asia
Detalles del proyecto
Coste total:EUR 299 200
Aportación de la UE:EUR 299 200
Coordinado en:Estonia
Tema(s):CITIZENS-2004-8.3.3 - Promoting international research and policy co-operation in social sciences and humanities
CITIZENS - Citizens and governance in a knowledge-based society
Convocatoria de propuestas:FP6-2004-CITIZENS-6See other projects for this call
Régimen de financiación:SSA - Specific Support Action
The Central Asian countries (Kazakhstan, Uzbekistan, Kyrgyzstan, Tajikistan, and Turkmenistan) are strategically located at the crossroads of the ancient Silk Road between China, the Middle East and Europe. This area was for centuries one of the cradles of civilisation. Today finds the countries of Central Asia (CA) in a period of rebirth. At the same time they have to withstand several threats such as ethnic diversity, border disputes and the processes of nation building as well as different religious beliefs and the rapid juvenescence of the population. All of these problems directly influence the rest of the world, and are directly connected to social sciences and humanities (SSH). Nowadays, new technologies are bringing everyone closer together than ever before in our history. In this situation it is easy to realise that our histories, cultures and even languages are linked and studies in SSH, without considering this, are therefore unthinkable. At the same time, it is extremely important that all parties should understand the same indications in the same way (e.g. academic recognition, accreditation, evaluation, quantitative indicators in SSH). The PHOENIX project constitutes an integrated set of networking and training measures for SSH community in CA using, besides the expertise of Member State (MS) partners, the expertise of existing EU funded projects (MORESS, HERA, INTAS ININ Continuing advice) and collaboration networks (COLLNET). The SSH community's increase in competence and expanded area of action will be achieved through workshops, information seminars and video conferences and video links to identify and motivate potential collaboration, and to boost the acquisition of knowledge about new trends in SSH and the role of SSH in ERA. Information gathering activities such as competence and research mapping in SSH, publications and dissemination will support SSH community need for new knowledge on CA and Europe SSH capabilities.
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The Frame Relay Encapsulation Process
Frame Relay takes data packets from a network layer protocol, such as IP or IPX, encapsulates them as the data portion of a Frame Relay frame, and then passes the frame to the physical layer for delivery on the wire. To understand how this works, it is helpful to understand how it relates to the lower levels of the OSI model.
First, Frame Relay accepts a packet from a network layer protocol such as IP. It then wraps it with an address field that contains the DLCI and a checksum. Flag fields are added to indicate the beginning and end of the frame. The flag fields mark the start and end of the frame and are always the same. The flags are represented either as the hexadecimal number 7E or as the binary number 01111110. After the packet is encapsulated, Frame Relay passes the frame to the physical layer for transport.
The CPE router encapsulates each Layer 3 packet inside a Frame Relay header and trailer before sending it across the VC. The header and trailer are defined by the Link Access Procedure for Frame Relay (LAPF) Bearer Services specification, ITU Q.922-A. Specifically, the Frame Relay header (address field) contains the following:
DLCI - The 10-bit DLCI is the essence of the Frame Relay header. This value represents the virtual connection between the DTE device and the switch. Each virtual connection that is multiplexed onto the physical channel is represented by a unique DLCI. The DLCI values have local significance only, which means that they are unique only to the physical channel on which they reside. Therefore, devices at opposite ends of a connection can use different DLCI values to refer to the same virtual connection.
Extended Address (EA) - If the value of the EA field is 1, the current byte is determined to be the last DLCI octet. Although current Frame Relay implementations all use a two-octet DLCI, this capability does allow longer DLCIs in the future. The eighth bit of each byte of the Address field indicates the EA.
C/R - The bit that follows the most significant DLCI byte in the Address field. The C/R bit is not currently defined.
Congestion Control - Contains 3 bits that control the Frame Relay congestion-notification mechanisms. The FECN, BECN, and DE bits are the last three bits in the Address field. Congestion control is discussed in a later topic.
The physical layer is typically EIA/TIA-232, 449 or 530, V.35, or X.21. The Frame Relay frame is a subset of the HDLC frame type. Therefore, it is delimited with flag fields. The 1-byte flag uses the bit pattern 01111110. The FCS determines whether any errors in the Layer 2 address field occurred during transmission. The FCS is calculated prior to transmission by the sending node, and the result is inserted in the FCS field. At the distant end, a second FCS value is calculated and compared to the FCS in the frame. If the results are the same, the frame is processed. If there is a difference, the frame is discarded. Frame Relay does not notify the source when a frame is discarded. Error control is left to the upper layers of the OSI model.
The Frame Relay Topologies
When more than two sites are to be connected, you must consider the topology of the connections between them. A topology is the map or visual layout of the Frame Relay network. You need to consider the topology from several perspectives to understand the network and the equipment used to build the network. Complete topologies for design, implementation, operation, and maintenance include overview maps, logical connection maps, functional maps, and address maps showing the detailed equipment and channel links.
Cost-effective Frame Relay networks link dozens and even hundreds of sites. Considering that a corporate network might span any number of service providers and include networks from acquired businesses differing in basic design, documenting topologies can be a very complicated process. However, every network or network segment can be viewed as being one of three topology types: star, full mesh, or partial mesh.
Star Topology (Hub and Spoke)
The simplest WAN topology is a star, as shown in the figure. In this topology, Span Engineering has a central site in Chicago that acts as a hub and hosts the primary services. Notice that Span has grown and recently opened an office in San Jose. Using Frame Relay made this expansion relatively easy.
Connections to each of the five remote sites act as spokes. In a star topology, the location of the hub is usually chosen by the lowest leased-line cost. When implementing a star topology with Frame Relay, each remote site has an access link to the Frame Relay cloud with a single VC.
This shows the star topology in the context of a Frame Relay cloud. The hub at Chicago has an access link with multiple VCs, one for each remote site. The lines going out from the cloud represent the connections from the Frame Relay service provider and terminate at the customer premises. These are typically lines ranging in speed from 56,000 bps to E-1 (2.048 Mb/s) and faster. One or more DLCI numbers are assigned to each line endpoint. Because Frame Relay costs are not distance related, the hub does not need to be in the geographical center of the network.
Full Mesh Topology
This figure represents a full mesh topology using dedicated lines. A full mesh topology suits a situation in which the services to be accessed are geographically dispersed and highly reliable access to them is required. A full mesh topology connects every site to every other site. Using leased-line interconnections, additional serial interfaces and lines add costs. In this example, 10 dedicated lines are required to interconnect each site in a full mesh topology.
Using Frame Relay, a network designer can build multiple connections simply by configuring additional VCs on each existing link. This software upgrade grows the star topology to a full mesh topology without the expense of additional hardware or dedicated lines. Since VCs use statistical multiplexing, multiple VCs on an access link generally make better use of Frame Relay than single VCs. The figure shows how Span has used four VCs on each link to scale its network without adding new hardware. Service providers will charge for the additional bandwidth, but this solution is usually more cost effective than using dedicated lines.
Partial Mesh Topology
For large networks, a full mesh topology is seldom affordable because the number of links required increases dramatically. The issue is not with the cost of the hardware, but because there is a theoretical limit of less than 1,000 VCs per link. In practice, the limit is less than that.
For this reason, larger networks are generally configured in a partial mesh topology. With partial mesh, there are more interconnections than required for a star arrangement, but not as many as for a full mesh. The actual pattern is dependant on the data flow requirements.
Frame Relay Encapsulation and Topology
The Frame Relay Encapsulation Process


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Post Subject: RJTTD download Tue Aug 09 , Download link for: [You must be registered and logged doesnt work. ATC_GAME has stop working. Back to top Go down. blajos. Admin please upload use mediafire or another hosting file which can multiple download.. Back to top Go down. ATCGAZ ATC3 Chief. Langpack Englisch v alpha 4: ?d=OJ4BAM8I Headon Patch v (all airports): ?d=1JG2NDFU FlightPlanGenerator v beta 4: Please note that the script is still in development and that this release is only a snapshot. Known bugs & problems: * RJBB is not. Air Traffic Controller - This game intends to put you into the hot-seat of an air traffic controller. Guide those planes to their correct destinations. This is a game of logistics and thinking ahead, sometimes you will need the right reflexes thou.
air traffic controller 3 pc hd free download. Airean Airean is a proof-of-concept application showing that eavesdropping of GSM traffic (voice calls. 10 Nov (Unrar with PASSWORD: ). 2. Install. 3. Crack Global ATC Simulator. (See Tutorial Video below if you don't know) 4. Play game. 5. Have fun ^^. (If you don't know how to install or have some problems, you can ask me on Tag CONTACT ME) (If download links are broken, you should request. 17 May From WOODE Soft: Take control over the air space above you, with this addictive air traffic control (atc) game. It is not a real simulator but it is close to it (it is supposed to be fun as well). Your objective is to direct airplanes to their destinations, to avoid mid-air crashes or proximity alerts and avoiding other.
I am a air traffic controller 3. · March 28, ·. Flightplangenerator REUPLOAD! /%5BMegafileupload%5DFlightplange [ Megafileupload] MediaFire is a simple to use free service for that lets you put all your photos, documents, music, and video in a single place so you. Join the ATC3/4 community at ATC3 Fan Site providing forums, FAQ, general info , and links about ATC1/ATC2/ATC3/ATC4 (I am an Air Traffic Controller/Bokukan) .


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Two lots of music today - from opposite ends of the spectrum.
First up is the Bowed Piano Ensemble. I've no idea how I came across them, but they make a beautiful, ethereal noise by, well, bowing piano strings (which are usually hit by padded hammers). Ten people gather round a single grand piano and make this wonderful noise, which sounds more like an orchestra than a single instrument. What's cooler than taking a long-established instrument and turning it into something else entirely?
If that's not to your taste, how about The Breeders? The Byzantine lives of the women at the heart of the band would go on for ever (Kim Deal = ex-Pixies, Tanya Donnelly = ex-Throwing Muses, later Belly then Kelley Deal replaced Donnelly etc. etc.) so I won't. They're been around forever and have done lots of interesting things. Pod was fun pop-punk. Last Splash is my high point, perhaps because the opening bass notes of 'Cannonball' instantly takes me back to the sticky sweaty dancefloors of my late teens (dance fans might recognise it: Prodigy's 'Firestarter' sampled it). It's youth and energy and fun all in one shiny pop package.
Play this very very loud:
After a few years of drug problems, side-projects and the usual stuff, they reformed in the past few years - Title TK is a lo-fi gem, while Mountain Battles is a lovely, rough, fuzzy slab of fun.
And while I'm in the mood: some Veruca Salt


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Sunday, December 6, 2009
Melody and Her Pal, Tim
Throughout our lifetime
many choices are made
and many paths are chosen.
Bridges are crossed,
and the rivers keep flowing.
Friends are made
and friends let go,
But Love is everlasting.
Today, on this 6th day of December,
Melody, our true friend
and most dedicated companion
of 16 years
crossed life's finish line.
With special thanks
on this sad Sunday
to veterinarian Kenny Leal
for opening his door and his heart.
Posted by Linda at 12:56 PM
Subscribe to: Post Comments (Atom)


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Your privacy is a prerequisite to everything that Turnstone does. This statement outlines our policy on how we manage the personal information we hold about our customers and others. It applies to all of our operations in Australia including visitors to our website. If you have any questions relating to this policy or to any information held by us please call: 0451 827 550.
Privacy is not something that I'm merely entitled to; it's a prerequisite.
Turnstone Pty Ltd. is bound in Australia by the National Privacy Principles contained in the Privacy Act 1988 (and subsequent amendments). For information on the National Privacy Principles please visit http://www.privacy.gov.au/materials/types/infosheets/view/6583#d
Our privacy policy will be reviewed from time to time to take account of new guidelines, laws and technology, changes to our operations and practices and changes to the environment.
The information we collect includes:
You are well within your rights to choose not to disclose any or all of the above information, however choosing not to do so may impact on your chances of securing a new job.
No personal information is collected from our website. Web usage data is not considered personal information.
Subject to some exceptions that are set out in the National Privacy Principles, you can gain access to the personal information that we hold about you. To make a request to access your personal information you will need to complete a short application form verifying your identity and specifying what you require. Please contact us for a Privacy Access Application Form. Please note:
Should you have any cause for concern or complaint about the management of your information, please call us on 0451 827 550 between 9am and 5pm Monday to Friday. Alternatively you can email us at. We will endeavour to respond to your query within 48 hours and resolve any issues you have promptly.


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Day 175 – The Pollenator
There's no better way to end a work day than some time on the trails with my wife, our dog and my camera. A strange flowering plant that I've never seen before caught my attention, and a bee showed up to add a little flair to the shot. I wish the bee had been frozen into the frame a little more clearly, but I wasn't expecting him to be there in the first place. Oh well.
"Click the pic" – looks better BIG.


text: well one is about how i had to work throughout college to support my family that took a toll on my gpathe other; on a six 6 point higher lsat score..which im still comtemplating on whether to send (i went complete at most schools this week)what do guys think? a NAY on the lsat addendum? am i asking for too much?


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There are numerous sorts of essays, thus it'll become confusing for the students to pick the sort of text to be written."You need to come from the essay knowing more on the area of the student." The individual essay is among the most crucial and most dreadful elements of a university program. Your personal article is a vital region of the college application procedure and you have to ensure that you just're writing it in a style that reveals your maturity and in a style that's professional. Now's tricks concentrate on the individual article. Before beginning composing your own private article it is extremely essential that you filter out your intended audience. Practice the directions if you choose to compose an adequate composition by the application deadlines. Practicing composition – creating and taking a look at the productive documents of individuals who arrived before you're two amazing systems to prepare yourself for creating scholarship and admissions documents. For online courses, pupils need to have a microphone in order that they can participate in course discussion." Faculties want to detect some colour, they wish to find some nature come through. Every faculty is searching for the finest potential student. The college would really like to understand about you. Bates University delivers brief advice on just how to create your program stick out. п»ї
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"The National Right to Life Committee, however, isn't stepping back. It released a statement Monday saying: 'Senator Barack Obama's four-year effort to cover up his full role in killing legislation to protect born-alive survivors of abortions continues to unravel.'
Tony Perkins, president of Family Research Council Action, also released a statement calling for Obama to apologize to voters.
'Senator Obama's position in the Illinois Senate was to oppose any legislation that would protect such innocent life. Everyone else was clear that the bill addressed infanticide not abortion,' he said, accusing Obama of 'twisting of the truth.'
Perkins claimed the campaign since clarified its position 'that it was the senator himself who was actually wrong on the facts.'"
He even lied or tried to hide the fact that he knows that life begins at conception at the forum presented at Saddleback Church on Saturday by claiming he is below the pay grade to declare when human life begins. B.S. Science and theology declare the samething, life begins at the moment of conception. He is a bigger liar than, dare I say it? Clinton!!