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John Elliott Drops Nike & Suicoke Collabs Alongside Cozy Layers for FW18
John Elliott prepares for the cold season with an on-brand blend of sportswear and California cool, blending skate influences with some timely menswear nods. "Delirium," the theme of the Fall/Winter 2018 collection, is a nod to the subtly distorted details that appear throughout the expansive range.
The label's signature skinny, washed denim and easy-to-layer hoodies are joined by an array of hefty layering pieces, ranging from corduroy puffer jackets to flannel overshirts, all inflected with rich color. Stripes, florals, plaids, tie-dye and paint-splatter appear in between solid-toned wool cardigans and heavyweight French terry tees, with suede Blackmeans riders jackets and satin bombers adding quiet luxury accents to the versatile range. Color-blocked Sail jackets, turtlenecks, translucent sweaters and distressed trucker jackets reflect Elliott's skill in blending disparate influences into a wearable mélange, with accessories coming in the form of sporty glasses and various...
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subset: commoncrawl


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R | | Adventure, Comedy, Drama
A preoperative transgender woman takes an unexpected journey when she learns that she fathered a son, now a teenage runaway hustling on the streets of New York.
Many scenes involve improvisation. The scene where the characters are riding in the car towards sunset is one of them: the director (Duncan Tucker) asked Felicity Huffman to start poking Kevin Zegers in the stomach and shoulder. Kevin Zegers stayed in character, and the director liked the ... ...
I got a phone call last night from a juvenile inmate of the New York prison system. He claimed to be Stanley's son.
Margaret: No third-person.
Bree: My son.
The first time they get in the car, Bree insists that Toby wear his seat-belt. A few shots later, she's clearly not wearing her seat-belt while driving. In the midst of a conversation, the seat-belt is fastened.
For all people of trans experience, For all people of any experience, and For my family.
English, Spanish
$1,452,303 (USA) (5 March 2006)
$9,015,303 (USA) (1 June 2006)
Check out our guide to horror, see what IMDb editors are watching, and more.


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I'm not gutted that our first home match will no longer be against Liverpool. I really don't expect to win that one.
Please just go then.. getting bored stiff of this saga. Guy is acting like such a dickhead tbh. I was in the "pay him" camp but he got what he wanted then wanted some more. We didn't suffer without him and he's ageing. Take the £60m, fucking reinvest it and come out better off.
Just want to say that this is by no means a step up too. Sideways move done out of a bigger payday, dick.
This RRRRRREEAAALLY isn't the time to get slack and fuck up in the transfer season.
I get that we need to pay for the stadium, but if ever we were going to go big it was now with the golden generation all primed and ready. It's now or never with this team. I'm convinced of that.
We've got a team that will crumble away bit by bit if they don't see progress. AND we've got a new stadium. Who the fuck wants to have a bad season in the first year in a new stadium?!?!
We need to be progressing to keep the team together, and I don't even see us guaranteeing top 4 right now.
For the Americans out there, in the UK a fanny isn't an ass, it's a pussy.
Don't know if that makes it more or less funny, but there you go.
Honestly if Toby doesn't sign a new deal I would prefer him gone. Don't want negativity around the team next season.
He's always been a pro. I don't feel there's any evidence to suggest he'll be a negative element if he stays another season.
Not if we actually want to make a deal. Maguire also has home grown status which always inflates the fee.
He also has 4 more years left of contract whereas Toby has one, and he's younger
My thought process if I was the freekick taker: "if I hit him in the balls enough times, maybe he'll stop doing it".
I like the idea of us getting Grealish, but he really does seem to be our top target. So fuck us too right?
He's not our top target, that would be Martial. Unlikely to get him but that doesn't mean Grealish is our top target
We've been told we can't have him. I don't see him as a legit/realistic target personally.
Liverpool. I don't know if they're going to win the league next season. But I do know this. They are going to batter us.
Downvote me all you like, but with the transfers they've made, and the transfers we haven't. This is the goddam truth.
You should remember though that we have effectively 'signed' Moura, Aurier and Winks for this coming season. Always takes a good year plus pre season for the new guys to work it out.
And it may be that someone like Skipp or Oakley-Booth or someone impresses in pre season and steps up. Or Onomah even, if he's kicked on after his loan spell (mixed to bad loan performances alone doesn't mean he hasn't learned from it).
I do remember that. It's not enough. Liverpool also did amasing business last year too.
They mean business. We don't. I know we have a stadium to pay for but this is the best team we've ever had. We either bolster it or watch it crumble away. There's no in between.
Yeah Liverpool has gone out and done exactly what we've needed to the last three summer windows... go big on essential targets to give them a serious shot at the title this coming season
I know about the stadium and all that, but farking hell it feels like we're squandering the best manager and collection of talent we've had in decades.
Even if we do make some moves in the next few weeks, we're again going into a season without proper preseason bedding-in time for new faces.
It's going to happen. Levy is simply being Levy, holding out as long as possible to get the cheapest price. It's just unfortunate that we take so freaking long to do a deal while he misses out on a crucial training period.
Edit: never mind lol https://twitter.com/RickSpur/status/1019608784149405699
Unfortunate is not strong enough. It's fucking stupid. Look how well Moura did last year. Players need a preseason if they're to stand a chance of making an impact in their first season . Poch said so himself.
Maybe my standards have been lowered so much by the home and 2nd kits but... I actually really like this one!
I never usually like 'messy' looking kits but this one has touches of Germany away, and the possibly even the Nigeria kit.
Maybe I'll change my mind about buying a kit this year.
Is Hairy McLairy really from Donaldon's Dairy? Because we never actually get to see the place in any of the books.
Can I add to that I want Keiran Trippier to become the next Beckham?
Layout and invasive adds, some of their content is decent such as whole transcripts of press conferences.
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Mr copywriter jobs
We are looking for a native British person for a SEO project that we ehave for one of our clients. We expect you to be familiar with writing SEO texts and distributing search terms throughout a text. We will provide the texts in english, and we would like you to proofread the texts and make any neccesary changes. It will be one text each month, on a continious basis. We expect, that you have e...
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Hey experts, I need a demo video for my website (transportation company). This will be Adobe After Effects CS5 (and above) project which will help mr to show express delivery process between sender and recipient. No keyframes or third-party plug-ins are engaged there. Just import my logotype, edit a text and adjust colors
Hi there, We are looking for a creative Amazon listing Copywriter for our parcel mailboxes. You will be asked to write clear and concise bullet points for our product descriptions, and Enhanced Branding Content. You should have experience with optimizing listings and knowledge on ranking keywords. Let us know if there's anything else we could do
Hi there- we are looking to hire a copywriter to write for our new secret project's website. Rosemary Water is a brand that launched in March 2017 and is a botanical water containing pure rosemary extract, concentrating the essential properties of the plant into a refreshing, luxurious still or sparkling beverage. Our new products are similar to this
for website, check front-end and back-end content, that its engaging, consistent and makes sense for users
We are an international network of discount codes' platforms. We provide coupons and voucher codes to millions of users around the globe. For a new project focused on the English market, we are looking for two copywriters with excellent writing skills, who can support the creation of SEO-based descriptions for our top shops. English fluency at a native level, creativity, dynamism and basic k...
Need native blog post writer to improve posts for a new blog. Exceptional English is needed no exception!
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Product copywriter needed.
Hello Omar, I'm hiring you regarding Mr. Ahmed payment
I'm looking for an italian copywriter NOT for SEO but people with strong skills in sales. (Sales Letters) I'm looking for a specialist in writing to sell. Niche: Health and Fitness ( We have to sell protein shakes and supplements)
The network of Mr. Move is all over the globe along with modern warehouse facilities. This way it is quite easy to ship your goods overseas. We provide special services for transporting vehicles and expensive musical instruments too. Its a logistic farm for them i made the website ; seo; smo; google adword
Hey Mr. Rodney I have a few Questions ! There is a Logo You have made For Kings shishas where you can see a lion with a crown ! So my question was is there a Copyright on this illustration because a store here is using it without premission or if you could give me the cintact dadta of the person who bought this illustration from you because i would
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This is a project for mrsports.com. We need a designer to come up with a new look based on our specifications. We will want the designer to show different looks that we can pick from to establish a direction. Then after a few rounds of tweaks, we will sign off on the new design look. It will then be the designers job to produce a working responsive HTML version of the design. MANDATORY: It wi...
I am launching a business selling bottarga online .I have a website ready but I need to change the images and the text .I can creat the majority of the content but I need help polishing the content as english is not my fist language
Do some copywriting for me. pic to a written doc. Please provide your details.
I have already written content. You need it to rewrite/recheck to make it more professional.
I have a PSD file of the logo with the Cat design. Mr. Marshall... I am open to change the font and text on the logo also lol I am looking for a cute animation video of the cat walking around, licking his paw sitting down, peaking around the logo.. several creative ideas If you win I will have many more small animations needed over the next several
Do you have a passion for wordsmithing and creating compelling content? If so, we are looking for a senior level copywriter to join our team and we're open to full time, part time or contract partnerships. Based in Broomfield, CO, we are an early-stage, B2B tech company in the burgeoning cloud computing (IIoT) space. We believe one can make a difference
We are looking for Greek native copywriter who will help us translate a scheme from English to Greek language. Deadline for this project is 17.8.2018.
VSL Duration: appr 2 min The landing page's discourse approach should be moderately hyped but not overhyped. The goal is to get the visitor excited and engaged.
We are looking MBA Marketing Fresher Freelancer 2017- 18 Pass-out batch Contact: Mr. Deepak
I need a copywriter, native english speaker, to write a set of short tourist guides (about 700 words per guide) In total about 50000 words. If you are interested, please attach to your bid a short example of a tourist guide, to show your stile, unless you have a relevant sample in your portfolio.
We are startup business.(Blockchain Technology) The project is exciting. Direct Global Hotel Booking Powered by Daaps(Decentralized applications). No Middlemen.0% Commission. Global hotel industry total retail value in (2018) - 554.64bn / USD. I am looking for a general virtual assistant and social media manager to assist me with my tasks. Project management ,attention to details ,social media ...
Our company is a company in Japan that produces wellness related products. We are looking for a copywriter for product descriptions to be used in English speaking regions in Asia like Hong Kong or Singapore. Mostly would be a brochure type data of about 1200 words.
I require content writer for my website which is currently being designed. I have four pages that i will need content written for. My business is a natural moisturiser manufacturer. Our moisturisers are packaged in glass or metal tins not plastic for health and environmental reasons. The ingredients are Shea Butter, Coconut Oil, Almond oil and Jojoba oil
i am hiring Mr. kuldeep s. for animated video lecture , he will animate 30 video for me.
Hello, we are looking for someone who has very good knowledge of the Swedish language and who have skills and experience to prepare the content and publish it on quality Swedish websites. These may be larger or smaller regional portals or portals related to a car topic. You will certainly be privileged if you have contacts and a list of several such resources. This is a long-term cooperation offe...
Hey Mr. Zahek Actually I Have Some Captured Session Of Charles Of Some Site . The Session Have All Api and data and it has some &signature = i need to decrypt or to find from what source it is generating . I have the formula of it its almost we have to re url encode it and it is done u need to find it and code it for me in php . Will pay 4000-5000 bucks
I need you to write some content for a website.
...font and style of the Cover page should be as shown in the pic below (Michael Conelley's cover page) i.e. the font of the Autor and Title etc, should be similar to the one from Mr. Conelley. The description of the image on the cover page is as followed: Its evening (dark) near railway tracks, you can see the headlights of a car (its not necessary for
We are looking for a native German writer who can write with deep research in Engineering field. Looking to hire soon. Only native person. Thanks
i need a quick recording english and chinese " This is the Corporate Trading Line for Mr William Lee. Please Hold the line and we will try to connect your call as soon as possible"
I'm looking few copywriters able to provide Article/content/ research writing for website project at Malaysia. Thats China base real estate company. This could be project base in one year terms. We still in proposal stage. Please text me if you're interested.
Logo shall be on my name Mr. Lalit K Jain I am Advocate Businessmen Author Lecturer hosts
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I am an agent that looks after one house in Cascais portugal. The owners of the house are called Mr and Mrs Simpson. My name is Priy Patel. When the guests arrive i wanted them to see a poster that says THIS IS THE SIMPSONS HOUSE. IT IS LOOKED AFTER BY APU. What i want is the image of the simpsons aster the word house. Instead of APU it should be
We are a digital marketing agency based in Australia looking for a copywriter specialised in Australian English. The task is to proofread our website (approx. 6 pages of 500 words). The right person will have future work from our clients.
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2015 Fed 100
Name: T.A. Summerlin
Title: Senior Adviser
Agency: Federal Communications Commission
Rebooting the FCC. Although the FCC has made news for its technology and telecommunications policy, the agency's IT gear is aging and dangerously decentralized. As senior adviser to CIO David Bray, Summerlin is the FCC's point man for streamlining acquisitions, speeding new products to users, engaging internal and external stakeholders, and developing more robust public-facing technology. He's as "subtle as a woodpecker," a non-FCC executive said, but highly effective. "Tony has been a key asset in assessing opportunities for short-term gains," Bray said, "while never losing sight of the longer-term goal of bringing FCC IT into a 21st-century service-delivery model."
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The telecom contract has the potential to reinvent IT infrastructure, but finding the bandwidth to take full advantage could prove difficult.
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text: 20SS Crystal rhinestone inset on silver chain. Sold by the yard. $3.50 PER YARDThis rhinestone banding features one row of size 20ss Czech pointed back rhinestones for extra sparkle, set into silver-toned metal. Can be attached to fabric by sewing or by using adhesive for solid surfaces. Banding is also known as rhinestones by the yard.I uses this chain when creating rhinestone motifs for bridal wear. There was flexibility that allows the chain to curve with the designs and was easier to stitch into place. It was also more convenient then stitch in one stone at a time. You can average about 3 stones per inch when spaced out.


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how do u change a water pump whaer about is it
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No offence...but if you can't find the water pump then you probably don't want to be changing it yourself. Assuming you have a 1.2 8v engine then it;s left side of the engine, back of the block...it's linked into the belt system. You'll need a new gasket to fit as well as a new pump.
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A variety of definitions of successful aging have been proposed, many of which relate to longevity, freedom from disease and disability, or preservation of high physical and cognitive function. Many behavioral, biomedical, and psychological factors have been linked with these various measures of successful aging, however genetic predictors are less understood. Parkinson's disease (PD) is an age-related neurodegenerative disorder, and variants in the α-synuclein gene (SNCA) affect susceptibility to PD. This exploratory study examined whether SNCA variants may also promote successful aging as defined by survival without neurological disease.
We utilized 769 controls without neurological disease (Mean age: 79 years, Range: 33–99 years) and examined the frequency of 20 different SNCA variants across age groups using logistic regression models. We also included 426 PD cases to assess the effect of these variants on PD risk.
There was a significant decline in the proportion of carriers of the minor allele of rs10014396 as age increased (P = 0.021), from 30% in controls younger than 60 to 14% in controls 90 years of age or older. Findings were similar for rs3775439, where the proportion of carriers of the minor allele declined from 32% in controls less than 60 years old to 19% in those 90 or older (P = 0.025). A number of SNCA variants, not including rs10014396 or rs3775439, were significantly associated with susceptibility to PD.
In addition to its documented roles in PD and α-synucleinopathies, our results suggest that SNCA has a role in survival free of neurological disease. Acknowledging that our findings would not have withstood correction for multiple testing, validation in an independent series of aged neurologically normal controls is needed.
Citation: Heckman MG, Soto-Ortolaza AI, Diehl NN, Carrasquillo MM, Uitti RJ, Wszolek ZK, et al. (2012) Evaluation of the Role of SNCA Variants in Survival without Neurological Disease. PLoS ONE 7(8): e42877. https://doi.org/10.1371/journal.pone.0042877
Editor: Mathias Toft, Oslo University Hospital, Norway
Received: March 19, 2012; Accepted: July 13, 2012; Published: August 13, 2012
Copyright: © Heckman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work is funded, in part, by a research grant for the American Parkinson Disease Association, the Morris K. Udall Parkinson's Disease Research Center of Excellence (NINDS P50 #NS072187) and the family of Carl and Susan Bolch. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Aging can be defined as a progressive, generalized impairment of function resulting in a loss of adaptive response to stress and an increasing risk of age-associated disease [1], [2]. Within this definition lies the paradoxical idea that individuals can age in a healthy manner, so-called successful aging, which is a topic that has received increased attention as a result of the dramatic increase in human life expectancy that has been witnessed during the past century. While longevity is clearly a key part of aging in a healthy manner, it is equally clear that it is not the only component, and that other factors require consideration [3]. The concept of successful aging was introduced by Rowe and Kahn, distinguishing "usual aging" from "successful aging", and referring to successful aging as freedom from disease and disability, preservation of high physical and cognitive function, and engagement in social and productive activities [4], [5]. A number of other definitions of successful aging have been put forth, many of which, in addition to longevity and disease, emphasize disability, physical, or cognitive functioning [6], [7].
Many different attempts have been made to identify characteristics associated with the various measures of successful aging that have been proposed. The majority of these reports have investigated demographic, behavioral, biomedical, or psychological factors, and have identified predictors such as absence of arthritis, better activities of daily living, and not smoking, among many others [6], [7]. However, fewer studies have examined genetic predictors. The identification of genetic factors related to specific aspects of successful aging has several potential benefits, for instance, shedding light on the underlying biological systems and processes involved in aging successfully, and possibly allowing for the identification of people who possess harmful variants of those genes, for whom intervention could potentially increase the likelihood of successful aging.
Due to their links to specific aspects of successful aging such as disease, physical functioning, and cognitive functioning, the study of age-related disorders offers promise in further understanding the mechanisms involved in the aging process. Parkinson's disease (PD) is one of the most prevalent age-related neurodegenerative disorders, with approximately 1.5% of the population older than sixty-five years being affected [8], [9], and at the center of genetic PD research is the α-synuclein gene (SNCA). Point mutations in SNCA were the first mutations identified in familial PD [10]. Subsequent studies showed α-synuclein to be the major protein component of the pathologic inclusion observed in PD, the Lewy body 11,12. Identification of genomic multiplication of the SNCA gene in familial PD demonstrated that over-expression could cause disease in a dose-dependent manner [13], [14]. This observation fitted with the theory that common variation at the SNCA locus increased risk of sporadic PD via a pathomechanism of limited over-expression [15]–[19].
We speculated that variation in age-related disease genes such as SNCA may not only affect morbidity, but also influence particular aspects of successful aging. More specifically, in addition to its role in PD, we hypothesized that variation in SNCA may be associated with neurological disease in general and longevity. Therefore, the primary aim of this exploratory study was to evaluate the association between common SNCA single nucleotide polymorphisms (SNPs) and survival without neurological disease.
Methods and Subjects
Ethics statement
The Mayo Clinic institutional review board approved all work. All participants provided written informed consent.
In evaluating the role of common SNCA variants in successful aging as measured by survival without neurological disease, we utilized a series of 769 controls without neurological disease seen at Mayo Clinic Florida. Unrelated controls were deemed to be free of neurological disease by a neurologist, and did not have a family history of neurological disease. Mean age in the controls was 79±11 SD years (Range: 33–99 years), and 385 (50%) were male. All controls were white and of European ancestry. Controls were mostly unrelated spouses/caregivers of neurological patients, and a subset of these controls are included in our aging sibpair study [20]. Utilizing this group of controls, we evaluated the association of SNCA SNPs with age, where since the probability of living longer without neurological disease increases as age without neurological disease increases, age in these controls is a measure of survival without neurological disease.
We supplemented the healthy control series with 426 PD cases also seen at Mayo Clinic Florida, in order to examine associations of SNCA SNPs with PD [21]. Mean age of PD cases was 72±11 SD years (Range: 30–92 years), mean age at PD onset was 62±12 SD years (Range: 26–85 years), and 233 (55%) were male. All PD cases were white and of European ancestry, and were examined and observed longitudinally by a neurologist and diagnosed with PD according to published criteria [22]. There are no known related samples within or between the diagnosis groups. All subjects self-identified ethnicity.
Genetic analysis
DNA was extracted from whole blood samples using standard protocols. Conserved regions (conservation score >200) were identified across SNCA (coding regions ±10 Kb) using the phastConst software embedded in UCSC Genome Browser (http://genome.ucsc.edu), based on the NCBI March 2006 assembly [23]. The conserved SNP approach was used to highlight potentially functional variation and takes into account the high levels of linkage disequilibrium at the SNCA locus. We identified 20 SNPs with a minor allele frequency >1% which were selected for analysis. The SNCA variants were genotyped on a Sequenom MassArray iPLEX platform (San Diego, CA; primer sequences are available on request) and analyzed with Typer 4.0 software. The rate of genotype calls was ≥95% for all SNPs.
Statistical analysis
Deviations of SNP genotypes from Hardy Weinberg equilibrium (HWE) in controls were assessed using chi-square tests, while linkage disequilibrium (LD) between SNPs in controls was assessed using r2 values. In evaluation of the primary study aim, we used logistic regression models adjusted for gender to examine whether the proportion of carriers of the minor allele for each SNP varied across age in controls, where age was considered as a continuous variable. After examination of genotype frequencies in the overall group of controls, we chose to consider each SNP under a dominant model (i.e. presence or absence of the minor allele) owing to the relatively small number of homozygotes of the minor allele for many of the SNCA SNPs. We also divided age into categories, and estimated the proportion of control carriers of the minor allele in each age category. When utilizing the overall case-control series, single SNP associations with PD were evaluated using logistic regression models adjusted for age and gender under a dominant model. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Owing to the fact that the primary analysis comparing the frequency of SNCA variants across age is exploratory in nature in that this has not been evaluated before, no adjustment for multiple testing was made, and p-values of 0.05 or less were considered as statistically significant. All statistical analyses were performed using R statistical software (version 2.11.9; R Foundation for Statistical Computing, Vienna, Austria).
There was no evidence of a departure from HWE for any of the SNPs (all P>0.05). LD between SNPs is summarized in Figure 1; there was moderate to strong LD between a number of SNCA SNPs, with many r2 values of 0.30 or greater.
Values are given as percentages out of a maximum of 100. Solid black boxes indicate an r2 value of 100.
For each SNCA SNP, the proportion of carriers of the minor allele in controls is displayed in Table 1 for seven different age categories: <60 years, 60–69 years, 70–74 years, 75–79 years, 80–84 years, 85–89 years, and ≥90 years. These age categories were chosen with the goal of displaying trends in as detailed a manner as possible, while maximizing the number of controls in each category. As seen in Table 1, there was a significant decline in the proportion of carriers of the minor allele of rs10014396 as age increased (P = 0.021), where 30% of controls younger than 60 were carriers, compared to 14% of those 90 years of age and older. Results were similar for rs3775439, which was in strong LD with rs10014396 (r2 = 0.84); the proportion of carriers of the minor allele decreased from 32% in controls younger than 60 to 19% in those 90 or older (P = 0.025). For all remaining SNCA SNPs, the proportion of carriers of the minor allele did not noticeably increase or decrease as age increased in controls (all P≥0.19).
In Table 2 we present single SNP associations with PD in the entire series of 426 PD cases and 769 controls. Of particular interest, rs10014396 and rs3775439, both of which were associated with survival without neurological disease in controls, were not associated with PD (ORs 0.92 & 0.95, P≥0.58). Significant protective associations in relation to PD were observed for rs1372519 (OR: 0.76, P = 0.034) and rs1372520 (OR: 0.76, P = 0.039). For the remaining SNCA SNPs, a number of significant risk associations with PD were observed, including rs356218, rs2736990, rs2572324, rs2737033, rs2583959, rs2737012, rs2619361, rs2619362, rs2619363, and rs2583988 (ORs between 1.39 and 1.64, all P≤0.026), all of which were in moderate to strong LD (Figure 1).
Lifespan in humans has been shown to display markable heritability, with estimates ranging between 20% and 30%, confirming that longevity is to some extent determined by genetic mechanisms [24], [25]. Identification of genetic variation influencing population mortality and specific aspects of successful aging may help characterize the overarching pathways and physiological processes that determine risk for common age-related diseases. Conversely, the study of age-related disease may provide greater insight into the molecular mechanisms that contribute to the aging process. In this exploratory study involving more than 750 controls free of neurological disease, our findings indicate that in addition to its known role in PD, SNCA may play a part in determining whether or not a given individual ages successfully as measured by the specific outcome of survival without neurological disease. More specifically, for two SNCA SNPs, rs10014396 and rs3775439, the minor allele was less common in older controls. The lower proportion of carriers of the minor allele for these two SNPs in the older controls suggests that unobserved individuals who are carriers of these alleles experience death or neurological disease at an earlier age and are therefore removed from the pool of controls free of neurological disease at later ages, indicating that the presence of these alleles increases the risk of neurological disease or death. The two age-associated SNCA SNPs were not among those that were associated with PD when supplementing the controls with the PD cases in disease-association analysis; this may be due to the different outcome measure used which relates not only to PD but to death and neurological disease in general.
Similar to the results of our study, other studies have demonstrated associations between genes involved in neurodegenerative disorders and successful aging outcomes. As described by Glatt et al. in their review of 29 different studies evaluating at least one other characteristic of healthy aging in addition to longevity [26], APOE, the known risk factor for Alzheimer's disease, has been implicated in successful aging in several studies, however this association has not been consistently identified, and further study is therefore needed. Walter et al., in their genome-wide association study [27], identified evidence of association with survival free of major disease for GRIN2B, which has been implicated in Parkinson's disease [28] and Alzheimer's disease [29]. These findings, taken together with those from our study, suggest that the role of age-related neurodegenerative disease genes should be further studied in relation to healthy aging in general.
Although not of primary interest in this study, it is worth highlighting the significant associations of SNCA SNPs with PD that were observed in this study and previous studies [15]–[19], [21]. Protective effects were observed for rs13752519 and rs1372520, which were in strong LD, while risk effects were also noted for a number of other SNPs that were also in relatively high LD. In addition to their known role in PD, SNCA variants have also been implicated in both diffuse Lewy body disease [30] and multiple system atrophy [31], [32], [33]. The associations between SNCA variants and survival without neurological disease that were observed in this study provide additional support for all of these findings and also further underscore the pleiotrophic nature of SNCA.
Several limitations are important to take into account in the interpretation of our results. There are other factors that are likely associated with survival free of neurological disease for which we did not collect information, and as such we cannot rule out the possibility that the associations of SNCA with survival free of neurological disease that we identified may be due in part to confounding factors. Also, owing to the exploratory nature of the study, we made no adjustment for multiple testing. The statistically significant decreasing frequencies of the minor allele for rs10014396 and rs3775439 as age increased in controls would not have remained significant after such an adjustment (P≤0.0058 considered significant after permutation adjustment for multiple testing), and therefore it is important to highlight that our findings require validation in an independent series of healthy individuals. Related to this, our sample size of more than 700 controls free of neurological disease is relatively small, and therefore the possibility of Type II error (i.e. a false negative association), particularly after adjustment for multiple testing, is important to consider. Larger series' of healthy controls, in particular healthy nonagenarians and centenarians, are needed in future evaluation of SNCA's role in the aging process. Finally, an important caveat of genetic aging studies is the possibility of population stratification given migration patterns and generational differences in lifestyle.
Acknowledging these limitations, our results indicate that in addition to its known role in PD and α-synucleinopathies, SNCA may influence the likelihood of survival without neurological disease. Our findings, though requiring validation in an independent series, suggest that further study of the role of SNCA variation in aging and cognitive function is warranted.
Author Contributions
Conceived and designed the experiments: MMC RJU ZKW NRGR OAR. Performed the experiments: AISO OAR. Analyzed the data: MGH NND. Contributed reagents/materials/analysis tools: OAR ZKW NRGR. Wrote the paper: MGH OAR.
- 1. Harman D (1991) The aging process: major risk factor for disease and death. Proc Natl Acad Sci U S A 88: 5360–5363.
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- 29. Stein JL, Hua X, Morra JH, Lee S, Hibar DP, et al. (2010) Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease. Neuroimage 51: 542–554.
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- 31. Scholz SW, Houlden H, Schulte C, Sharma M, Li A, et al. (2009) SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol 65: 610–614.
- 32. Ross OA, Vilariño-Güell C, Wszolek ZK, Farrer MJ, Dickson DW (2010) Reply to: SNCA variants are associated with increased risk of multiple system atrophy. Ann Neurol 67: 414–415.
- 33. Al-Chalabi A, Dürr A, Wood NW, Parkinson MH, Camuzat A, et al. (2009) Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy. PLoS One 4: e7114.


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Japanese Satsuma porcelain vase with enameled and relief decoration having depictions of figures, trees and pagodas. Measures 12 1/2" (31.5cm) height + 4 1/2" (11.4cm) brass base.Read more
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Pair of Antique Kutani Japanese Porcelain Vases
A pair of large antique Kutani Japanese vases dating back to 19th century in very good condition. They are fully decorated with vases of polychrome flowers, vegetal elements and birds. Unusual large size, they are 80 cms high, they have a wide flaring form with ruffled rim ornated with small coloured flowers and butterflies inside and shaped white porcelain handles with leaves and grapes motifs in relief. Period: 1800 Article size: height: 80 cm diameter: 30 cmRead more
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Bedroom. Wednesday , May 10th , 2017 - 05:57:52 AM
The favorite portion of a bedroom, but for the dresser is the wardrobe! The bedroom is where we can spend atleast 8 to ten hours daily so bedroom can be the most significant room in your residence. Simply choose the furniture design and color that you believe will fit in your bedroom and you are surely going to be amazed by the beauty that vanity sets can provide.
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When you are traveling or going on vacation, you are probably going to end up staying at a hotel. However, all hotels are not created equal. Finding a quality hotel that is not going to charge you an arm and a leg can be tricky. Use these tips to get a good deal on your next hotel reservation.Do comparison shopping online. Often you"ll need to do s… Read More
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Vacation planning requires covering a lot of different details. First, you need to pick your destination, and then, you must arrange for transportation. You also have to find a hotel, which can be complicated if you don't know the area. This article provides some great advice to help you.When planning a vacation, be sure to make all of your hotel r… Read More


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Large Counter Height Table
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As adjective, larger, largest
of more than average size, quantity, degree, etc
; exceeding that which is common to a kind or class; big; great:a large house; a large number; in large measure; to a large extent
on a great scale:a large producer of kitchen equipment
of great scope or range; extensive; broad
grand or pompous:a man given to large, bombastic talk
(of a map, model, etc
) representing the features of the original with features of its own that are relatively large so that great detail may be shown
famous; successful; important:He's very large in financial circles
generous; bountiful; lavish
unrestrained in the use of language; gross; improper
unrestrained in behavior or manner; uninhibited
free (def )
As noun
the longest note in mensural notation
generosity; bounty
As adverb
with the wind free or abaft the beam so that all sails draw fully
As Idioms
at large, free from restraint or confinement; at liberty: The murderer is still at large
to a considerable extent; at length: to treat a subject at large
as a whole; in general: the country at large
Also, at-large
representing the whole of a state, district, or body rather than one division or part of it: a delegate at large
Also, at-large
having a general, as opposed to a specific, role in an organization or project: She's the magazine's editor-at-large
in large, on a large scale; from a broad point of view:a problem seen in large
Also, in the large
As noun
a table or display case on which goods can be shown, business transacted, etc
(in restaurants, luncheonettes, etc
) a long, narrow table with stools or chairs along one side for the patrons, behind which refreshments or meals are prepared and served
a surface for the preparation of food in a kitchen, especially on a low cabinet
anything used in keeping account, as a disk of metal or wood, used in some games, as checkers, for marking a player's position or for keeping score
an imitation coin or token
a coin; money
As Idioms
over the counter, (of the sale of stock) through a broker's office rather than through the stock exchange
(of the sale of merchandise) through a retail store rather than through a wholesaler
under the counter, in a clandestine manner, especially illegally:books sold under the counter
As noun
extent or distance upward:The balloon stopped rising at a height of feet
distance upward from a given level to a fixed point:the height from the ground to the first floor; the height of an animal at the shoulder
the distance between the lowest and highest points of a person standing upright; stature:She is five feet in height
considerable or great altitude or elevation:the height of the mountains
Often, heights
a high place above a level; a hill or mountain: They stood on the heights overlooking the valley
the highest part; top; apex; summit: In his dreams he reached the heights
the highest point; utmost degree:the height of power; the height of pleasure
high rank in social status
As noun
an article of furniture consisting of a flat, slablike top supported on one or more legs or other supports:a kitchen table; an operating table; a pool table
such a piece of furniture specifically used for serving food to those seated at it
the food placed on a table to be eaten:She sets a good table
a group of persons at a table, as for a meal, game, or business transaction
a gaming table
a flat or plane surface; a level area
a tableland or plateau
a concise list or guide:The table of contents in the front of the book includes chapter names and page numbers
an arrangement of words, numbers, or signs, or combinations of them, as in parallel columns, to exhibit a set of facts or relations in a definite, compact, and comprehensive form; a synopsis or scheme
(initial capital letter) Astronomy
the constellation Mensa
a flat and relatively thin piece of wood, stone, metal, or other hard substance, especially one artificially shaped for a particular purpose
a course or band, especially of masonry, having a distinctive form or position
a distinctively treated surface on a wall
a smooth, flat board or slab on which inscriptions may be put
the tablets on which certain collections of laws were anciently inscribed: the tables of the Decalogue
the laws themselves
the inner or outer hard layer or any of the flat bones of the skull
a sounding board
the upper horizontal surface of a faceted gem
a gem with such a surface
As verb (used with object), tabled, tabling
to place (a card, money, etc
) on a table
to enter in or form into a table or list
Parliamentary Procedure
Chiefly U
to lay aside (a proposal, resolution, etc
) for future discussion, usually with a view to postponing or shelving the matter indefinitely
to present (a proposal, resolution, etc
) for discussion
As adjective
of, relating to, or for use on a table:a table lamp
suitable for serving at a table or for eating or drinking:table grapes
As Idioms
on the table, Parliamentary Procedure
submitted for consideration
turn the tables, to cause a reversal of an existing situation, especially with regard to gaining the upper hand over a competitor, rival, antagonist, etc
:Fortune turned the tables and we won
We turned the tables on them and undersold them by percent
under the table, drunk
as a bribe; secretly: She gave money under the table to get the apartment
wait (on) table, to work as a waiter or waitress:He worked his way through college by waiting table
Also, wait tables
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Fusion Provida, one of our trade brands, are looking for a Service Engineer to join the team at our Hatfield branch, propelling your career forward with a business that can provide you with industry-leading training and excellent opportunities for progression.
As a FTSE 100 company, Wolseley UK is the UK's leading distributor of plumbing and building materials and products, serving professionals in the construction industry through a number of trading brands. We're looking for people that are passionate about what they do, and want to shape and develop their career.
About the role:
Our Engineers support to the Workshop Supervisor / Depot Manager to ensure that all hire equipment is promptly and correctly serviced and made available for hire in a safe, clean and serviceable condition complete with all necessary components and documentation. You will repair, service and calibrate our customer's equipment complete with all necessary components and documentation.
About you:
To be selected for telephone interview you must be able to demonstrate;
- A background in electrical or hydraulics
- A full UK driving license
- IT / Computer literate
- City and Guilds / NVQ or similar qualification in mechanical or electrical engineering is ideal but not essential
The working hours for this role are 42 hours a week, Monday – Friday 7:30am – 5:30pm
There is no better time to apply than right now!
Required skills
- Electrical Engineering
- Hydraulics
- Mechanical Engineering
- driving licence


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Brand Label: Bernhardt
ITEM MOVED TO ARCHIVE: On February 12, 2018 1:06 am, Fashion Stylist Online noted this item may be out of stock at Neiman Marcus because it was not referenced in their latest online catalog. If this item is out of stock at Neiman Marcus, you may be able to find similar fashions sold there or elsewhere on our Bernhardt Designer Brand Directory.
Available for Purchase Online at Neiman Marcus for $2599.00Pin It
Handcrafted breakfront dresser with nine drawers. Overall, 66.25"W x 20.1"D x 39"T. Metal frame below top in burnished brass finish. Ash solids and quartered white oak veneers. Eight legs with metal ferrules. Adjustable glides; anti-tip kit included. Imported. Boxed weight, approximately 275 lbs.
Shop other brand label items from Bernhardt on FashionStylist.com.
This item was published for sale online by Neiman Marcus on February 11, 2018 10:46 pm and last updated by us February 12, 2018 1:06 am.
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New promo codes and links offering limited time promotions, sales coupons, and special offers on Bernhardt designer fashions and accessories will be posted on each designer label apparel page. For the latest up to date information on this Bernhardt Clarendon 9 Drawer Dresser Overall | Clothing fashion item, including product specifications, ordering options, pricing, shipping details, high resolution pictures, shopper comments, and other sales media, visit the Neiman Marcus Online Store.