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Durham, North of England
Blues Brothers Tribute Band
Yorkshire , North of England

subset: commoncrawl


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hepatic G6Pase-alpha deficiency causes metabolic reprogramming, leading to enhanced glycolysis and elevated hexose monophosphate shunt that along with impaired autophagy can contribute to hepatocellular adenoma/carcinoma development in glycogen (zeige GYS1 Proteine) storage disease type Ia.
We envisage these data and models finding utility when investigating the muscle-specific functions of the 11beta-HSD1/G6PT/H6PDH triad.
Data show that glucose-6-phosphatase and perilipin-5 (G6PC/PLIN5) are upregulated in notch1 knockout (KO) mice.
We conclude that G6PD (zeige G6PD Proteine) deficiency at the level of the animals in the present study may not be a risk factor for developing CSN-OT, but this remains to be verified for human subjects
The results strongly suggested that the increase of glucagon (zeige GCG Proteine) levels could account for the induction of G6pc expression in the kidneys and intestine of L-G6pc-/- mice.
PPARalpha (zeige PPARA Proteine) is responsible for glucose production through the up-regulation of hepatic G6Pase gene expression during fasting or type 2 diabetes animal models
gene transcription in H4IIE cells mediated by hepatocyte nuclear factor-4 alpha's stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha
Evidence for the expression of the catalytic domain of hepatic glucose-6-phosphatase in pancreatic islets.
Loss of G6pt activity causes neutropenia, and local production of the chemokines KC and macrophage inflammatory protein-2 (zeige CXCL2 Proteine) are defective in G6pt-/- neutrophils.
G6pc expression was functionally silenced by adenovirus-mediated delivery of short hairpin RNA.
Microarrays revealed that G6PC mRNA was upregulated following GDNF-mediated dopaminergic differentiation of SH-SY5Y cells. Array association analysis showed three downregulated microRNAs that could possibly influence G6PC translation. Although qRT-PCR results were not significant, they did support the microarray findings with regard to trend. Western blotting also confirmed increased G6PC protein expression following GDNF
3'-UTR SNP rs2229611 in G6PC1 affects mRNA stability, expression and Glycogen (zeige GYS1 Proteine) Storage Disease type-Ia risk
crystal structures of the FoxO1 (zeige FOXO1 Proteine) DNA binding domain in complex with the G6PC1 promoter
Notch1 expression is reduced and glucose-6-phosphatase and perilipin-5 (G6PC/PLIN5) are upregulated in liver biopsies from nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) patients.
Mutation analysis of the G6PC gene revealed that GSD Ia accounted for 11% in GSD patients with involvement of liver. Three patients were homozygous for R83C mutation. In addition, a novel stop mutation, Y85X, was identified in a patient with the typical features of GSD Ia.
Post-translational regulation of the glucose-6-phosphatase complex by cyclic AMP (zeige APRT Proteine) is a crucial determinant of endogenous glucose production and is controlled by the glucose-6-phosphate transporter (zeige SLC37A4 Proteine).
ApoA-IV (zeige APOA4 Proteine) colocalizes with NR4A1 (zeige NR4A1 Proteine), which suppresses G6Pase and PEPCK (zeige PEPCK Proteine) gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose.
By direct DNA sequencing, three novel G6PC variations were identified which expanded the G6PC mutation spectrum, and provided conclusive genetic evidences for the definitive diagnosis of the Chinese patients.
This study is the first to demonstrate a functional relationship between the critical gluconeogenic and glycogenolytic enzyme G6PC with the metabolic adaptations during glioblastoma invasion.
The spectrum of mutations in the G6PC gene.
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.
, Glc-6-Pase-alpha
, glucose-6-phosphatase
, G6Pase
, G6Pase-alpha
, glucose-6-phosphatase alpha
, glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)
, glucose-6-phosphatase catalytic subunit


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Lisztomania (1975) Special Edition sign now
In May 2009 Digital Classics released the 1975 Ken Russell film 'Lisztomania' on DVD. While many were glad that the film was released, the major problem with the DVD was the lack of extras; only a trailer was included. This was especially unfortunate since Ken Russell's movies are rarely released to DVD.
I propose that you release a proper edition of the movie. Along with the trailer, please include a commentary by Ken Russell, a vintage making-of and possibly a retrospective documentary as well. Any other special features you can come up with yourself will be great.
Sign The Petition
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This site is a voluntary effort by one woman to help shoppers find products made in USA. No warrantees are expressed or implied.
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Which mattresses sold in the USA are made here too? With a few exceptions, most mattresses sold in this country were made in this county. Here are some top picks from.
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Diy Web Chairs DIY Network has ideas on how to keep kids entertained during a Halloween party. Men's practical skills are being challenged at home as more women are opting to pick up the tool box and carry out do-it-yourself (DIY) and home improvements. And a functional furniture layout is very important as well," said Lex. Autonomous helps
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All mattresses are not created equal. If buying a mattress from The Mattress Factory, located at 35 South Ave. in Fanwood, odds are, it has not even been built yet. There is not a warehouse with an enormous amount of inventory.
The two reports paint a conflicting view of the USA: in 186 years, shifting from.
We no longer have to drive to a well-lit department store to spend hours laying down on mattresses just to get one we will like. The explosion of online mattress startups. It's also 100% made in the USA. Type of mattress: A bouncy,
The UK's leading manufacturer of organic mattresses, baby mattresses, organic sheets and bedding in a range of sizes or made to measure.
We got a demand letter that says they want $3 million and that all these different.
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American Freight Furniture and Mattress has recently opened four Arizona. This.
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We believe a mattress hand crafted by experienced people will out-perform any mattress created in an automated manufacturing process.
Knoll Office Furnishing Accessories Knoll, Inc. (NYSE: KNL) designs and produces furniture, textiles, leathers, accessories, and architectural and acoustical elements for the office, home and places of higher education. Overall sales for Knoll in third quarter 2017 declined by. For Office; Products; By Application; Open Plan;. Accessories; By Brand. Knoll Office; KnollStudio; By Designer. To receive news and updates
Mattresses made after July 2007 also have a federal tag at the foot of the mattress.Sold exclusively at IKEA stores nationwide and online at www.ikea-usa.com from October 2000 through May 2014 for about $100. Importer: IKEA North.
Certified organic mattresses and bedding made in the USA
We only use U.S., high-quality foams that are CertiPUR-US certified to ensure that they are safe, don't contain harmful chemicals, and have a low Volatile Organic.


text:
- Trending Now: More Trending:
- hogwash probity sequacious inadmissible oligarch, pejorative
Recent Examples of bias crime from the Web
But as the nation faces a spread in bias crime incidents, the family wants to ensure the public remembers one of the worst hate crimes of the 20th century.
Levin said the analysis found a clear connection between the frequency of the racially motivated Russian ads and the number of bias crimes reported.
Jerry Palmer said last week there no was evidence of a bias crime.
Wareing will present the department's report on bias crimes at a City Council committee meeting Wednesday morning.
Wareing said a group of Spanish-speaking men were the targets of a bias crime earlier this year.
The Edison Police Department and the bias crimes unit of the Middlesex County Prosecutor's Office are investigating the incident, according to Edison Police Chief Tom Bryan.
The Seattle Police Department reported last week that bias crimes have been increasing in the city, and this year's total for the first six months, 178, has already surpassed the number for all of last year, 128.
The Essex County Prosecutor's Office has said the incident is being investigated as a possible bias crime.
These example sentences are selected automatically from various online news sources to reflect current usage of the word 'bias crime.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.
First Known Use of bias crime
in the meaning defined aboveSee Words from the same year
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What made you want to look up bias crime? Please tell us where you read or heard it (including the quote, if possible).


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Blog: Act now to keep receiving just-style newsletters
Leonie Barrie | 14 August 2017
You may have noticed a red alert bar at the top of just-style's weekly and daily newsletters asking you to "Act now to keep receiving the just-style newsletter."
Under the EU General Data Protection Regulation we need permission from everyone on our mailing lists to allow us to continue to contact them.
If you don't opt in, you're likely to miss out. It will only take a second to click on this link to ensure you continue to receive our essential industry updates.
Sectors: Apparel, Fibres & fabrics, Finance, Footwear, Manufacturing, Retail, Social & environmental responsibility, Sourcing, Technology, Trade
Hong Kong sustainability scoop
We led on just-style last week with a world exclusive scoop on a number of new projects being unveiled in Hong Kong next month – including the first mill being set up in the territory in more than hal...
Spotlight on Central America sourcing
A worsening political and social crisis in Nicaragua is having a spillover effect in Central America, where the spectre of rising violence in Guatemala and El Salvador is threatening to undermine appa...
Trump trade war may hit garment prices
With US president Donald Trump now threatening to impose tariffs on all US$500bn of goods imported from China, the upcoming trade war will undoubtedly hit garments. But replacing China means replacing...
New re:source online strategic planning tool launched
Today marks an exciting milestone in just-style's nearly 20-year history, with the official launch of our new re:source online strategic planning tool....
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Market research


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OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
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Jason M. Duran is from Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
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A Review of the Basis of Autologous Stem Cell Therapy for Coronary Artery Disease
Jason M. Duran and Jon C. George
Review Article: J Clinic Experiment Cardiol 2011, 2:130


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User Gets Blank Page Upon Form Submission
(Doc ID 1994185.1)
Last updated on MARCH 20, 2018
Applies to:Oracle Health Sciences InForm - Version 4.6.0 and later
Information in this document applies to any platform.
User gets blank page following submission of a form after data was entered. There error message in the lower left hand size of the browser page (when clicked on and pop up window renders) shows the following message:
Permission denied
To view full details, sign in with your My Oracle Support account.
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East Midlands, Nottinghamshire, Newark
Salary band: £40k - £50k
This highly-regarded and established firm based in Newark in Nottinghamshire is looking to appoint a full-time or part-time Private Client Solicitor or Private Client Legal Executive to their market-leading private client department. As a Private Client Lawyer you will have from 3+ Years' PQE and be able to demonstrate detailed knowledge and technical expertise in dealing with complex private ...
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Lincoln, Grantham, Spalding, Newark
Salary band: £30k - £40k
Private Client Solicitor urgently sought for hugely successful, multi office law firm in Lincolnshire. Successful applicants will ideally have 2+ years experience in Private Client Law and will be a qualified solicitor or legal executive. Our client is seeking an experienced Private Client Solicitor to handle their own caseload with minimal supervision but also someone who will become an i...
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Kenilworth, Leamington Spa, Warwick
Salary band: £20k - £25k
- IT Support Analyst - Warwickshire - £20-£23,000 A rare opportunity to join a highly respected organisation, who are leaders within their field. My client are looking to recruit a customer focused Support Analyst with excellent communication skills to provide, 1st / 2nd line Windows / PC /Server / Infrastructure support to their user base. You will ideally have 2 years experience in working i...
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Nottinghamshire, Nottingham, Grantham, Newark, Mansfield
This Nottinghamshire law firm is looking to recruit a Conveyancer or Conveyancing paralegal. You will need to have at least 6 months conveyancing experience and should be knowledgeable of the full conveyancing process. Caseload experience is preferable but not essential. You will be working closely with the Conveyancing Partner and need to have excellent communication skills with clients. Fo...
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East Midlands, Lincolnshire, Lincoln, Grantham, Newark
This progressive regional law firm is looking to recruit a Secretary to join their Commercial Property department in Lincoln. You will need to have experience of producing legal forms such as Lexis Nexis and will need to have excellent IT and Audio Typing skills. The successful applicant will be providing secretarial support to the Commercial Property team on their workloads by preparing docum...
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This dynamic regional law firm is looking to recruit a Float Legal Secretary to join their office in Lincoln. You will need to have knowledge of production of legal forms such as Oyez and Lexis Nexis as well as excellent IT and Typing Skills. You will be providing full secretarial support to all the teams to cover any required workload which may arise. For further information on this and other...
Lincolnshire, Nottinghamshire, Lincoln, Newark
Salary band: £25k - £30k
This successful, multi-office practice is recruiting for an experienced personal injury fee earner. You will be picking up a full caseload of fast track and multi track personal injury claims (up to £50,000 in value), covering a broad range of claims. Portal experience is required. For further information on this and other exciting opportunities, or to discuss your situation in complete conf...
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Lincolnshire, Nottinghamshire, Lincoln, Newark
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This multi-office Lexcel Accredited law firm are recruiting for an experienced employment solicitor. You will be dealing with a varied caseload of employee and employer matters. Advising on Employment Tribunal matters, unfair dismissal, discrimination, redundancy, TUPE and settlement agreements. This is a fantastic opportunity for the right candidate to assist in developing a growing departmen...


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There either is or is not, that's the way things are. The colour of the day. The way it felt to be a child. The saltwater on your sunburnt legs. Sometimes the water is yellow, sometimes it's red. But what colour it may be in memory, depends on the day. I'm not going to tell you the story the way it happened. I'm going to tell it the way I remember it.
The Lizzie Bennet Diaries is an innovative, original episodic video and social media series produced for the web. Adapting Pride and Prejudice to the modern era, Lizzie Bennet tells the classic Jane Austen tale from the point of view of an Elizabeth "Lizzie" Bennet who grew up in a world of cell phones, video cameras, and social media. The series was created by popular YouTube personality Hank Green and Streamy Award winning web video writer Bernie Su.
The holiday season is bringing more than cheer for actress Jessica Capshaw. The Grey's Anatomy star announced on Monday that she and her husband, Honest Company co-founder Christopher Gavigan, are expecting their fourth child. "The holidays have certainly arrived … All of our lives are being added to by the lights, the music and cheer!!" she captioned a photo of her family at a Christmas tree farm on Instagram. "This year our family has reason to further broaden our smile … baby number four is on the way!! I am a lucky, lucky girl…"
The quickest way to tell whether an actor is serious about his or her career is to look at their "headshot".Is it a professional photo? Or is it a snapshot taken on prom night? If you're using a snapshot, it's like showing up to race the Indy 500 in a VW Beetle. Nobody is going to take you seriously. I'm sorry, people… you can send me as much angry e-mail as you want about this, but it's true! Don't tell me you're destined to be a major Hollywood star but you cannot scrape together the cash to get professional headshots.
The Grinch from Dr. Seuss' How the Grinch Stole Christmas! The Musical stole the spotlight at the Empire State Building's 86th Floor Observatory December 14, 2012, to promote the musical's limited holiday engagement. Discover the magic of Dr. Seuss' classic holiday tale as it comes to life on stage. Featuring the hit songs "You're A Mean One, Mr. Grinch" and "Welcome Christmas," The Grinch discovers there's more to Christmas then he bargained for in this heart-warming holiday classic.
All actors and actress | all rights reserved | photos by googler | design by en000t


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US and UK researchers launch trial to study treatment approaches for multiple sclerosis
Researchers at the University of Nottingham and Nottingham University Hospitals NHS Trust, UK, have collaborated with a team from the Cleveland Clinic in Ohio, US, for a clinical trial for the treatment of multiple sclerosis (MS).
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news
Related Links:
Feasibility and Effects of Structured Physical Exercise Interventions in Adults with Relapsing-Remitting Multiple Sclerosis: A Pilot Study
Elisabet Guillam ó, Álvaro Cobo-Calvo, Guillermo R. Oviedo, Noémie Travier, Juan Álamo, Oscar A. Niño-Mendez, Antonio Martínez-Yelamos, Sergio Martínez-Yelamos, Casimiro Javierre
Source: Journal of Sports Science and Medicine - Category: Sports Medicine Source Type: research
AbstractCladribine is a deoxyadenosine analogue prodrug that preferentially depletes lymphocytes, key cells underlying multiple sclerosis (MS) pathogenesis. Cladribine tablets (Mavenclad®) represent the first short-course oral disease-modifying drug (DMD) for use in MS. The tablets, administered in two short courses 1 year apart, are indicated for the treatment of adults with highly active relapsing MS on the basis of data from pivotal clinical trials, including the phase 3 study CLARITY and its extension. A cumulative cladribine tablets dose of 3.5 mg/kg administered in this fashion in CLARITY reduced clini...
Source: CNS Drugs - Category: Neurology Source Type: research
Morphology-Specific Discrimination between MS White Matter Lesions and Benign White Matter Hyperintensities Using Ultra-High-Field MRI ADULT BRAIN
CONCLUSIONS: Nonconfluent lesions of>3 mm with ≥1 central vein were the most sensitive and specific differentiators between patients with MS and control subjects.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Hosseini, Z., Matusinec, J., Rudko, D. A., Liu, J., Kwan, B. Y. M., Salehi, F., Sharma, M., Kremenchutzky, M., Menon, R. S., Drangova, M. Tags: ADULT BRAIN Source Type: research
Impact of Focal White Matter Damage on Localized Subcortical Gray Matter Atrophy in Multiple Sclerosis: A 5-Year Study ADULT BRAIN
CONCLUSIONS: WM tract disruption accounts for a small percentage of atrophy in connected subcortical gray matter when controlling for overall disease burden and is not the primary driver in most cases.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Fuchs, T. A., Carolus, K., Benedict, R. H. B., Bergsland, N., Ramasamy, D., Jakimovski, D., Weinstock-Guttman, B., Kuceyeski, A., Zivadinov, R., Dwyer, M. G. Tags: ADULT BRAIN Source Type: research
AbstractRituximab, a monoclonal antibody to CD20, is an effective treatment for relapsing remitting multiple sclerosis (MS) reducing relapse rate by at least 50% over time. Although the mechanism for this clinical benefit is unclear, rituximab depletes circulating B cells, which can perform antigen presentation and stimulation of T cells. Another anti-CD20 drug, ocrelizumab, has recently been FDA approved to treat both relapsing remitting and progressive forms of MS. While long-term effects of ocrelizumab use are essentially unknown, long-term use of rituximab has been associated with the development of progressive multifo...
Source: Journal of Neurology - Category: Neurology Source Type: research
Drugs that help repair the nerve cell lining that 's damaged in multiple sclerosis were found to target certain enzymes. The finding could help researchers develop new treatments for multiple sclerosis.
Source: NIH Research Matters from the National Institutes of Health (NIH) - Category: Consumer Health News Source Type: news
Publication date: Available online 13 August 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Barry A. HendinAbstractInterferon beta therapies have been effective in the treatment of relapsing forms of multiple sclerosis for over 2 decades. These therapies have varying routes and schedules of administration but broadly similar clinical and radiologic efficacy. The most commonly reported adverse effects are flu-like symptoms and injection site reactions. The most recent addition to the class is peginterferon beta-1a, which is administered subcutaneously every 2 weeks. Although clinically stable patients with m...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionAdministrative data can be used to identify individuals with incident ON and TM, and to distinguish those with monophasic syndromes from those with an incident presentation of MS.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Maria Blonda, Antonella Amoruso, Tommaso Martino, Carlo Avolio
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Journal of Neuroimaging, EarlyView.
Source: Journal of Neuroimaging - Category: Radiology Authors: CourtneyCasserly , Estelle E.Seyman , PaulaAlcaide ‐Leon , MelanieGuenette , CarrieLyons , StephanieSankar , AntonSvendrovski , StefanBaral , JiwonOh Source Type: research
More News: Clinical Trials | Hospitals | Multiple Sclerosis | Pharmaceuticals | Study


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Cristiano Ronaldo's Real Madrid talks appear set for another completely predictable twist
June 10
02:42 2018
Max Verstappen sweeps Friday F1 practice in MontrealRegarding how often that happens, Ricciardo said: "I wouldn't say a lot, but we have a pretty good off-track relationship". It is the Italian team's first time on pole in Montreal since seven-time champion Michael Schumacher managed it in 2001.
Trump Invitation to Russia Deepens Rift With America's AlliesTo Trump's suggestion that Russian Federation be welcomed back to the group, allies had mixed responses. "In the interest of all". Donald Trumps's decision to pull out of the Iran nuclear deal also demonstrated his reluctance to toe the line of his allies.
How to get help for someone who might be suicidalThe Associated Press contributed to this story . "They might actually bring up specifically that they're thinking of suicide". And CDC also discourages media from reporting on suicides, which risks lowering awareness and stigmatizing mental health.
UFC 225: Australia's Robert Whittaker primed for Yoel Romero fightHe jokingly responded that it's a "long flight" from his home in Australia and added, "I'm fighting somebody". Romero was given an hour to lose the weight he needed but failed to make it for the UFC 225 event tomorrow.
Michel Barnier pours cold water on UK Brexit backstop planJust 0.85 percent responded that they had previously wanted Northern Ireland to join Ireland and now wanted to remain British. Both sides want a deal by October to avoid barriers on the Irish land border that might fuel new conflict in the north.
Marcus Rashford Scores Thunderbastard In Costa Rica FriendlyA nice problem to have, says Max Liu, as he discusses the big questions in attack and defence. If England qualify they will face either Poland, Senegal, Colombia or Japan from Group H.
Entry of India, Pakistan strengthens security cooperation of SCO: Chinese officialThe SCO has two sub-divisions including Regional Anti-Terrorist Structure (RATS) and SCO Secretariat. PM Modi is expected to hold about six bilateral meetings with leaders of other SCO countries.
Curry's Warriors sweep Cavs for second straight National Basketball Association titleIt was the second time the Warriors have secured the championship in Cleveland during Kerr's four-year tenure. After the half the Warriors held an over 20 point lead, extending it to over 25 points by the final quarter.
Simona Halep beats Sloane Stephens to win French OpenA foot injury - and then surgery - had put her career on ice for 10 months and her ranking had nosedived to 323 in the world. She first came close to winning the French Open in 2014, losing a three-set final to Maria Sharapova .
Salmonella outbreak linked to pre-cut melon, CDC saysThose who reported illness said they had eaten pre-cut cantaloupe, watermelon, honeydew melon, or a fruit salad mix with melon. However, for some, the diarrhea may be so severe that hospitalization is necessary.
LeBron can't save himself, so he'll leave Cleveland after losing NBA FinalsLeBron James , who after the game revealed that he was playing with a severe injury to his shooting hand, only attempted 13 shots. He can't be guarded now - and he wants to keep growing. "Unbelievable feeling to come in here on a mission and get the job done".
Trump invites National Hockey League champ Capitals to White House but not NBA winnersIn the meantime, Game 4 of the NBA Finals tips off tonight. "We're not going to invite either team", Trump said. It's good that guys are sticking to what they believe in and what they want to do.