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October 22, 2012 08:28 ET
TORONTO, ONTARIO--(Marketwire - Oct. 22, 2012) - Liberty Silver Corp. (TSX:LSL) ("Liberty Silver" or the "Company") announced today that the cease trade orders imposed by the Securities and Exchange Commission and the Ontario Securities Commission have expired. Trading in its shares on the TSX in Canada will resume today, Monday, October 22, 2012. For the present, the Company's stock will not immediately be listed, traded or quoted on any of the OTC Markets. The Company is taking steps to meet requirements necessary to permit its stock to resume trading on the OTCBB. The Company's stock may be traded in the US on the "grey market" or through US broker dealers who have access to the TSX.
The Company advises the investment community that it has never provided any form of compensation to a newsletter writer or anyone else for investment research or to recommend investment in the Company's shares. The Company also advises that it has no contractual or other relationship with Mr. Robert Genovese, BG Capital Group or any other company owned or controlled by Mr. Genovese (the "Genovese Companies") other than a subscription to a private placement in November 2011 by a company controlled by Mr. Genovese. The Company has engaged Spinnaker Capital Markets Inc. and Navigator Ltd. to provide investor relations services for the Company. The Company also confirms that Spinnaker Capital Markets Inc. and Navigator Ltd. do not have, and have never had, a contractual or other relationship with any of Mr. Genovese and the Genovese Companies. In addition, the Company confirms that Mr. Genovese has never had the right to nominate, and has not nominated, an appointee to the Board of Directors of the Company, and the officers and directors of the Company have not had, and have never had, a business relationship with Mr. Genovese concerning the Company.
The Company wishes to advise the investment community that all official information regarding the Company must be derived solely from disclosure documents filed on www.sedar.com, www.sec.gov and the Company's website (www.libertysilvercorp.com).
"Liberty is pleased to have the trading suspension concluded promptly. Without exception, the Board and management of Liberty take their regulatory responsibilities very seriously and will continue their commitment to full cooperation and transparency with regulators and the market", said Geoff Browne, Chairman and CEO of Liberty Silver.
Trinity Silver Project Disclosure
As a result of a review by staff of the Ontario Securities Commission, we are providing the following information regarding the Trinity Silver Project to clarify our disclosure.
Overview of the Trinity Silver Project
Liberty is focused on exploring and advancing mineral properties located in North America. The Trinity Silver Project, located in Pershing County, Nevada is the Company's flagship project. The Trinity Silver Project is approximately 10,500 acres in size and includes a former producing mine that represents approximately one percent of the geographic extent of the project. Liberty Silver has the right to earn a 70 percent interest in the Trinity Silver Project from Renaissance Gold Inc. ("Renaissance") subject to certain obligations.
The Trinity Silver Project does not contain a mineral reserve and is not currently in production. Any decision to place the Trinity Silver Project into production requires the support of a feasibility study prepared in accordance with National Instrument 43-101. At this time the Company has engaged consultants to prepare a scoping study, also known as a preliminary economic assessment, but a scoping-level study does not have sufficient detail or costing estimates to support a prudent production decision. Accordingly, any decision to commence production on the Liberty Silver Project is neither imminent nor assured, and investors cannot assume that the Liberty Silver Project hosts an economic mine at this time.
Trinity Silver Project NI 43-101 Report
A National Instrument 43-101 Report on the Trinity Silver Project was prepared by Paul D. Hartley, Geologist, and Michael M. Gustin, P.Geo., of Mine Development Associates of Reno, Nevada, and Daniel W. Kappes, P.Eng., of Kappes, Cassiday & Associates of Reno under the title, "Technical Report on the Trinity Project - Pershing County, Nevada". The National Instrument 43-101 Report is dated December 1, 2011 with an effective date of August 9, 2011, and is filed on www.sedar.com. The report was prepared for the Company and Renaissance, the optionor of the Trinity Silver Project. Messrs. Paul D. Hartley, Michael M. Gustin, and Daniel W. Kappes are independent consultants to both the Company and Renaissance. Messrs. Gustin and Kappes are "qualified persons" under National Instrument 43-101. The following is a summary of the resource estimate for the Trinity Silver Project provided in the technical report. Please note, based on the reasonable cut-off grade, discussed below, the current inferred resource contains 11.64 Moz Ag. Any other mineral resource estimates, reconstructed estimates, Company estimates, exploration targets, historical stockpile or leach pad estimates, should not be relied upon.
Trinity Inferred Mineral Oxide Resources
Trinity Inferred Mineral Sulphide Resources
The oxide resources are listed using a cutoff grade of 0.65 oz Ag/t. This cutoff grade was chosen to capture mineralization potentially available to open pit extraction and heap leach processing, and it was derived using a $17 per ounce silver price (three-year average) and a 75% heap leach recovery factor. For the sulphide mineralization, a 1.3 oz/ton Ag-equivalent cutoff grade, chosen to reflect potential open-pit mining, milling, and production of concentrates by flotation. The cutoff assumes 90% recovery by flotation of the silver, lead, and zinc, and metal prices of $17 per ounce for silver and $0.80 per pound for both lead and zinc.
The inferred resource is based upon assay results from a historic database of 306 drill holes as well as processing and recovery data from the historic operation and metallurgical testing. A total of 40 cross sections spaced at 100ft intervals across the deposit were used for the modeling of the Trinity mineral domains. The technical report noted that some of the assay results from different assay laboratories were inconsistent, but such data was viewed as sufficiently reliable for the purposes of inferred resource estimates. Subsequent to the technical report, drilling conducted by the Company in 2012, see below, provided assay results that support the inferred resource estimate.
Silver mineralization at Trinity occurs as oxidized and unoxidized sulfides in veinlets, as fracture controlled mineralization, and as disseminated zones of tabular mineralization primarily within Tertiary rhyolite porphyry, aphanitic rhyolite, and volcaniclastic rocks.
In addition to the inferred resource defined in the National Instrument 43-101 compliant technical report, the Trinity project has potential mineralized extensions to the north, southwest and at depth below the current pit, that have been drilled previously. These extensions are outside the defined National Instrument 43-101 Report resource area but have the potential to significantly expand the size and scope of the project. The next phase of the project will include a drilling program to attempt to bring these extensions into National Instrument 43-101 compliance.
2012 Geophysical Program
In May 2012, Liberty completed a geophysical program at the Trinity Silver Project, located in Pershing County, Nevada. The Gravity and Induced Polarization (IP) surveys were successful in locating significant new drilling targets concealed by alluvial cover and in delineating the structural fabric of the district. The geophysics program was designed and interpreted by Jim Wright of J.L. Wright Geophysics. All the new data and the substantial amount of historic data relating to past operations at the Trinity Project have been input into a GIS database which will be used to further define future drilling and development of the current inferred resource and multiple exploration targets.
A possible northern extension of the Trinity silver deposit is hypothesized based upon the gravity survey. Historic IP data, acquired in 1983 (the "Historic IP"), indicates a possible northern continuation over this area as well. Historic airborne magnetic results coupled with the gravity and new IP also suggest a continuation of the known mineralization to the southwest along the Trinity fault. The gravity and Historic IP data, coupled with several other data sets, indicate that several target areas exist, including two possible target areas along the strike extensions to the known silver mineralization, and several other untested chargeability anomalies similar to that of the Trinity silver deposit.
2012 Resource Area Drilling Program
In May 2012, Liberty completed a drilling program in the resource area of the Trinity Silver Project consisting of 18 reverse circulation drill holes. Drilling was directed to the exploration of selected areas adjacent to the inferred resource zone identified in the Company's 2011 National Instrument 43-101 technical report (the "Resource Area"), as well as confirmation of that resource.
Eighteen vertical drill holes were completed to depths of up to 1,500 feet in rhyolite and underlying metasedimentry host rocks by reverse circulation for a total of approximately 20,000 feet. Drilling tested parts of five (5) geographic domains in the vicinity of the southern end the Trinity open pit mine and the National Instrument 43-101 Resource Area. Sixteen holes intercepted sample intervals greater than 1 opt silver ("Ag") with grades ranging from 0.56 to 15.66 opt Ag. Sulfide zone samples contain ranging from 0.01 to 1.7 % lead ("Pb") and 0.01 to 1.6 % zinc ("Zn").
In addition to 18 holes drilled during the 2012 drilling program, approximately 395 holes were drilled during the period from 1982-2007, mainly by US Borax. While approximately 50 of these holes are widely spaced throughout the approximate 13 square-mile area of interest, the large majority are located within an approximate one square mile area centered on the Trinity open pit silver mine. Based on historical and current assays, all holes contain anomalous silver throughout. Any previous disclosure by the Company related to the approximate grade based on this drilling should not be relied upon.
Acquisition of Hi Ho Silver Property
In October 2012, Liberty completed the acquisition of approximately 100 acres located adjacent to the former Trinity Mine on the Company's Trinity Silver Project (the "Hi Ho Property"). The Hi Ho Property was the only acreage not controlled by Liberty Silver or its joint venture partner Renaissance on the Trinity land package.
The Hi Ho Property completes the land package controlled by Liberty Silver and Renaissance. The joint venture comprises over 10,500 acres of contiguous land in an historic Nevada mining district, which includes the Trinity Mine and several other exploration targets. US Borax operated the Trinity Mine from 1988 to 1989, where it produced over 5 million ounces of silver. Operations at the mine were suspended when silver prices declined to less than $5/oz in the late 1980's. Based upon the drilling results available to the Company from the US Borax drill programs on the Hi Ho Property, the inclusion of the Hi Ho Property has the potential to increase the mineral resources available to the Company. The Company is also currently evaluating the internal data in conjunction with its recent drilling and geophysical data to determine future drilling targets. The data will be used to update the Company's current National Instrument 43-101 report.
In closing the Hi Ho Property transaction, Liberty Silver paid cash consideration of US$250,000 plus transaction expenses, issued 2,583,333 Liberty Silver common shares (the "Liberty Silver Shares") to the vendors at a deemed value of US$1,860,000 (US$0.72 per share), and also granted the vendors a 2% net smelter royalty on future production from the Hi Ho Property. In addition, pursuant to a registration rights agreement between Liberty Silver and the vendors, Liberty Silver will pay the vendors additional consideration as follows:
The total consideration for the acquisition of the Hi Ho Property is being applied to Liberty Silver's expenditure commitment under its earn-in agreement with Renaissance, pursuant to the applicable area of interest provisions. With the addition of the Hi Ho Property payment, Liberty Silver has contributed in excess of 85% of its required US$5,000,000 expenditure commitment to earn a 70% interest in the Trinity project. Pursuant to the terms of its earn-in agreement with Renaissance, Liberty Silver has until March 29, 2016 to incur the balance of its expenditure commitment and, in addition, produce a bankable feasibility study the following year.
Quality Assurance/Quality Control
Liberty Silver uses comprehensive, industry standard QA/QC protocols for diamond drilling, core recovery, handling, sampling, shipping and assaying. All drill hole samples were analyzed using ICP-MS by American Assay Laboratories, Reno, Nevada. Analytical precision and accuracy were monitored by Minerals Exploration and Environmental Quality, Reno, Nevada, including the use of certified reference materials (standards), blank samples, and duplicate samples. A senior Liberty Silver geologist supervised drill hole sample collection by the driller, Boart Longyear, Elko, Nevada, at the drill site and chain of custody throughout the program was unbroken. Drill hole deviation surveys were done by IDS, Elko, Nevada.
Tim Percival, MA, CPG, of Reno, Nevada, a consultant to Liberty has reviewed the technical data in this press release and is a Qualified Person as defined by National Instrument 43-101.
About Liberty Silver Corp.
Liberty Silver Corp. is focused on exploring and advancing mineral properties located in North America. Liberty Silver is led by a skilled, experienced management team and board of directors with significant experience managing exploration, development and mining projects. Liberty Silver is committed to creating value for its shareholders by advancing its current projects utilizing its mitigated risk approach to developing new resources on its current properties, and acquiring new properties that have the potential to increase their resource base. The Trinity Silver Project, located in Pershing County, Nevada, is Liberty Silver's flagship project. Liberty Silver has the right to earn a joint venture interest in the 10,579 acres Trinity property pursuant to the terms of an earn-in agreement with Renaissance Gold Inc.
Information on the Company is available on the Company's website www.libertysilvercorp.com, or in the SEDAR and EDGAR databases.
Cautionary Statements
This News Release includes certain "forward-looking statements". These statements are based on information currently available to Liberty Silver and Liberty Silver provides no assurance that actual results will meet management's expectations. Forward-looking statements include estimates and statements that Liberty Silver's future plans, objectives or goals, including words to the effect that Liberty Silver or management expects a stated condition or result to occur. Forward-looking statements may be identified by such terms as "believes", "anticipates", "expects", "estimates", "may", "could", "would", "will", or "plan". Since forward-looking statements are based on assumptions and address future events and conditions, by their very nature they involve inherent risks and uncertainties. Actual results relating to, among other things, results of exploration, project development, reclamation and capital costs of Liberty Silver's mineral properties, and Liberty Silver's financial condition and prospects, could differ materially from those currently anticipated in such statements for many reasons such as: changes in general economic conditions and conditions in the financial markets; changes in demand and prices for minerals; litigation, legislative, environmental and other judicial, regulatory, political and competitive developments; technological and operational difficulties encountered in connection with Liberty Silver's activities; and other matters discussed in this News Release and in filings made with securities regulators. This list is not exhaustive of the factors that may affect any of Liberty Silver's forward-looking statements. These and other factors should be considered carefully and readers should not place undue reliance on Liberty Silver's forward-looking statements. Liberty Silver does not undertake to update any forward-looking statement that may be made from time to time by Liberty Silver or on its behalf, except in accordance with applicable securities laws.
The Toronto Stock Exchange does not accept responsibility for the adequacy or accuracy of this News Release. No stock exchange, securities commission or other regulatory authority has approved or disapproved the information contained herein.
Kevin O'ConnorInvestor Relations(416) firstname.lastname@example.com Silver Corp.Manish Z. KshatriyaExecutive VP & CFO(888) firstname.lastname@example.com
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2015 Mustang GT SEMA Build
Parked to2015 Ford Mustang GT
byCGS Performance
CGS Performance packed plenty of upgrades into this Mustang GT seen at the 2014 SEMA Show. Enhanced with their own cat-back exhaust system and cold-air intake alongside other notable products including a powerful Whipple supercharger, this pony is one of a kind.
Vehicle Info: 2015 Ford Mustang
More from this Profile:
Project 2011 F-150
Project CGS Widebody Mustang
Project 2015 Ford Mustang GT

subset: commoncrawl


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I'm not sure if I'm in the right place, but my problem is that I can't get the game World of Warcraft working at my new college. I assumed only that there might be a firewall of some sort coming with the connection. Everytime I log in or my friend logs in, the game will run normally for about 1 minute.. then all hell breaks loose and my character dies from the latency being changed from the normal 200 ms or so to the 25000 ms I'm seeing today. Any action at all takes about a minute to respond. I really don't think it's anything on my end since my laptop works fine with the internet cord I plug into it at home. They have this wierd log in to their wireless connection thing, where you have to start up your explorer and log in. Sometimes it takes a few start ups for the link to if go to the log in.
The wierd thing is, I was playing just fine on the first day I moved in. The game worked perfectly. Could they have perhaps found I was playing it and somehow messed with my computer so it wouldn't work? I should say surfing the web, internet explorer and everything, still works just fine. I'm just wondering, is there anyway to bypass this firewall or whatever it is? Or am I never to see my orc rogue pwn a gnome again? Just ask if you need more info.
P.S. My friends told me that some students from the college in my hometown had to install Linux in order to be able to play WoW. Perhaps that?


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San Diego Summer Wedding Trends
With wedding season now in full swing, we'd like to take a moment to foretell the 2013 summer trends, and at L'Auberge all that glitters is… GOLD. One of the season's hottest trends pays homage to a classic era of Gatsby, with a modern twist. The L'Auberge Del Mar Wedding Team is seeing gleaming glam accents, scintillating sequins, and lustrous linens in golden notes and we couldn't be more thrilled!
Gold allows our newlyweds to add a dash of romantic L'Auberge sparkle in an accent color for accessories, décor or attire. Or, for the full luxe effect, bring gold tones front and center; a bold choice that creates a truly remarkable twinkling evening by the sea! Either way we love to see the classy element redesigned for our 2013 couples. So this summer, the Wedding Team here at L'Auberge says don't forget your something old, something new, something borrowed, and that golden hue! …After all, our ocean view can always be your something blue.
Check out our Pinterest wedding boards for some golden inspiration.
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Welcome to the World Trade Center Portland!
The World Trade Center Portland, located on the Waterfront in Downtown Portland, Oregon, is regarded as one of the city's most elegant and spacious venues for events of all sizes. Well known for providing a stunning ambiance, elegant backdrop and offering the finest combination of breathtaking views, distinctive service, and unparalleled cuisine, the World Trade Center Portland is the best choice for events ranging from an innovative business meeting to a romantic wedding and reception. The World Trade Center Portland offers a number of rooms, styles and flexible configurations to choose from and accommodates people for an array of business and personal events. Contact us today to schedule a walkthrough and see how the World Trade Center Portland would be the ideal setting for your next event. It is sure to leave a lasting impression on you and your guests.


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Adjustable Clothes Rack
Adjustable clothes rack allows you to conveniently hang garments straight from the washer or dryer. It is collapsible and removable for quick, easy storage. It assembles easily in less than 5 minutes with a Phillips screwdriver. The rotating arms pivot independently to accommodate various configurations. It also easily attaches with scratch-resistant magnets to most full-size washers or dryers.


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An update from Lael C Melville, PsyD, a 2016 M.Div. candidate and president of the Perkins Black Seminarians Association, who also is blogging at "Following the Passion of the Cross to El Salvador":
Each morning a faithful few (Dr. Recinos, Edwin, David, Billy and myself) leave at 6 a.m. for our morning run. What a blessed peaceful time to reiterate old stories and share new stories while simultaneously creating a story in the moment to be told at a later time.
Today was no different then the other days that we have been in El Salvador … full of adventure. Today's adventure took us to: Mister Coffee coffeehouse, tour the Museum UCA and Metropolitan Cathedral (burial site of Monsignor Romero), visit to the Romero Foundation (legal organization that pursues social justice), lunch back at the hotel, and visit to The Passionist Foundation (an organization that responds to gang violence through education, job training, social intervention, housing, etc.). These site visits and lectures remind me that the problems inherent in the human condition can be solved through the ultimate reality, a relationship with Jesus Christ.
The problems or challenges here in El Salvador are much like those of most of the world. One such problem is violence. Father Antonio, head of the Passionist Foundation, described violence as the source of conflict. He further described violence in terms of: illness or the inability to get appropriate medical treatment; lack of expressed love in a culture that is predominately machismo; discrimination (based on gender or ethnicity); and lack of food (Father Antonio, The Passionist Foundation Lecture, March 11, 2014).
To respond to the problem of violence Father Antonio has created a social service program. This dynamic program responds to an array of gang-related scenarios. One of the goals of this program might be to improve the lives of those who have been impacted by violence.
By contrast, the Romero Foundation responds to the problem of violence through the legal system. This organization provides legal support for social justice issues such as reparation for families of missing persons kidnapped and murdered during the civil war.
Finally, the Metropolitan Cathedral is the burial site for Monsignor Oscar Romero, who responded to the problem of violence through his role as archbishop. His pursuit of social justice cost him his life.
Each of these agencies and person has a common component. That component is Jesus Christ or an affiliation with the Catholic Church. This affiliation usually includes a belief or acknowledgement of Christ as Savior and the Bible as the word of God. The Christian faith tradition often includes going to church, participating in prayer and a celebration of the eucharist (communion).
In summation, perhaps the best response to violence in El Salvador and around the world is our faith in Jesus Christ. This faith reaches from God to human beings. It can teach us how to respond to violence. The programs mentioned in this writing and Monsignor Oscar Romero are evidence of the power and impact of the Christian faith tradition's response to violence. Christian faith is the constant in these examples. It allows these agencies and a person(s) to become more than a response to violence; Jesus Christ becomes the hope that comes with a 6 a.m. day.


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February 01, 2013 13:48 ET
OTTAWA, ONTARIO--(Marketwire - Feb. 1, 2013) - Today, the Honourable Lisa Raitt, Canada's Labour Minister, commended Garda Security Screening Inc., the United Steelworkers (USW) and the United Food and Commercial Workers International Canada (UFCW Canada) following ratification of new collective agreements by members at nine Ontario airports.
"I am very pleased that Garda Security Screening Inc. and both unions have reached agreements at several Ontario airports," said Minister Raitt. "Strong labour-management relations benefit the economic prosperity and security of Canadians."
The USW union independently represents some 220 employees at the Ottawa MacDonald-Cartier International Airport and about 230 employees working at airports in Sarnia, Hamilton, Kitchener/Waterloo region, Timmins, Windsor, Sudbury and Sault Ste. Marie. All of these employees are responsible for the airport security screening of passengers. Their previous collective agreements expired on March 31, 2012.
The UFCW Canada Local Union 175 represents about 35 employees at the Thunder Bay International Airport who are also in charge of security screening for passengers. Their previous collective agreements expired on March 31, 2012.
Garda is the largest pre-screening services provider to the Canadian Air Transport Security Authority (CATSA).
The agreements were reached with assistance from the Labour Program's Federal Mediation and Conciliation Service. The Federal Mediation and Conciliation Service provides dispute resolution and dispute prevention assistance to trade unions and employers under the jurisdiction of the Canada Labour Code.
This news release is available in alternative formats upon request.
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Ashley KelahearPress SecretaryOffice of Minister Raitt819-953-5646Media Relations OfficeHuman Resources and Skills Development Canada819-994-5559
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Photos: A look at the Globe's Style magazine covers
Photos: A look at the Globe's Style magazine covers
Style magazine's fall fashion issue is out this Sunday. Model Kayla Mayhew from Maggie Inc. was photographed at Boston's Verb Hotel for the cover. Take a look at past Style magazine covers.
MassArt student Erin Robertson graced the Most Stylish Bostonians cover in spring 2014.
Model Alisa O. from Elite NY was photographed at Oakes Ames Memorial Hall in North Easton for the fall 2013 issue.
Flock Boston co-owner Dani McDonald on the cover of the Globe's 25 Most Stylish Bostonians of 2013.
Singer, songwriter Shae Rose on the 2012 25 Most Stylish Bostonians cover.
The spring 2012 Style magazine.
The 2011 25 Most Stylish Bostonians with bartender Whitney Pallend.
The 2011 spring Style magazine cover was shot on location in the Art of the Americas Wing and Shapiro Family Courtyard at the Museum of Fine Arts.


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Joker no Kuni no Alicein Reviews
(Laughs nervously)
Sheep is about to dedicate a review to her favorite game, Joker no Kuni no Alice~
It is a visual novel game that requires clicking the mouse most of the time. Indeed, a lazy girl's game. (Laughs)
I don't think many of you know this game so to whom it may concern, dozo~ ↓
Ratings for this game: PG13, very mild romance, no nudity, foul words are bleeped and just lots of lemony love.
Language: Japanese
There are no motion pictures for this visual game, note that down please. <^-^>lll


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Wat Phra Borommathat Worawihan
This is an old temple on the bank of the Chao Phraya River. Located 4 kilometres from the town, it can be accessible by Route Nos. 340 and 3183. There is an old pagoda housing Lord Buddhas relics. It had been originally constructed with laterite in the Khmer period and was renovated in the Ayutthaya and Rattanakosin periods.


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Kristin Chenoweth, Nicole Richie & the Hilton Sisters Glam Up At Fashion Week
Kristin Chenoweth, Nicole Richie, Jamie Chung, Byrdie Bell, Paris and Nicky Hilton, Shenae Grimes, Aviva Drescher, Kelly Bensimon, Adrienne Bailon and Tinsley Mortimer. These were a few of the VIPs on hand at the Clos du BoisRouge & Pixi Beauty Daily Style Sessions party during New York Fashion Week. The party, which ran from Sept. 9-12, introduced Clos du Bois Rouge Cosmétique by Pixi – a new makeup collection inspired by the wine company. All proceeds from the sale of Clos du Bois Rouge Cosmétique by Pixi will go to Step Up Women's Network. Check out photos of the stars getting dolled-up at the event.


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Statistical Areas
Metropolitan Statistical Areas (MSAs), Micropolitan Statistical Areas, Metropolitan Divisions, and Combined Statistical Areas (CSAs)
Statistical areas are defined (geographically delineated) by the Office of Management and Budget in bulletin no. 15-01 issued July 15, 2015, and the definitions are updated as new information warrants.[1] [2] When OMB adds a new statistical area, BEA creates a time series for it starting in the earliest year in which data is available, even though it may not have had any urban area at the time. Similarly, when OMB changes the definition of a statistical area, BEA recreates the time series for that area, using the new definition for every year in the time series, published at the scheduled release date of the data set.
[1] See 2010 Standards for Delineating Metropolitan and Micropolitan Statistical Areas published in the Federal Register, Vol. 75, No. 123, June 28, 2010, pp.37245-37252, and a correction published in the Federal Register, Vol. 75, No. 129, July 7, 2010, p.39052.
[2] OMB metropolitan area revision bulletins
[2] OMB metropolitan area revision bulletins


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Agendas, Alternatives, and Public Policies, 1976, 1977, 1978, 1979 [United States] (ICPSR 28024)
Published: Mar 18, 2011 View help for published
Principal Investigator(s): View help for Principal Investigator(s)
John W. Kingdon, University of Michigan
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Summary View help for Summary
This data collection was created to study agenda-setting and alternative specification in the federal government. It concentrates on two federal policy areas, health and transportation, but the theories generated in the research may be quite widely applicable beyond those two areas. The aim of the work was not to study how issues are decided in some authoritative process like a congressional vote, but instead to study how issues get to be issues in the first place, how items rise and fall on the governmental agenda, and how the alternatives from which choices are made are generated.
The results of the study were published in John W. Kingdon, Agendas, Alternatives, and Public Policies (First Edition, Little Brown, 1984; Second Edition, HarperCollins, 1995; Longman Classics in Political Science Edition, Longman, 2003; Updated Second Edition, with Epilogue on Health Care Reform, Longman, 2011). The study's methods are described in detail in the Appendix to that book, and are included as part of the documentation for this data collection.
The major data source is a set of interviews that John Kingdon conducted in four waves (the summers of 1976, 1977, 1978, and 1979), with well-informed respondents either in the federal government (both congressional and executive) or involved in health or transportation policy around the federal government (e.g., lobbyists, journalists, academics, consultants). "Elite and specialized" interviews, to use Lewis Dexter's terminology (see Elite and Specialized Interviewing, Northwestern University Press, 1969), are conducted differently than standard survey research interviewing. The idea is to have a two-way conversation with a well-informed and highly involved respondent, rather than strict question and response. As such, the list of questions used was not a hard-and-fast interview schedule or questionnaire, but a kind of guide. The questions were not always asked in the same order, and indeed, not all of the questions were always asked. Question wording may have varied slightly from one interview to another. Various ad hoc probes were inserted as they seemed appropriate. Sometimes in this sort of interview, the interviewer makes a statement rather than asking a question. Still, the central questions were usually asked in roughly the same wording. Thus, when the interview write-up says "Q1," that is the first question in the standard list of questions used.
Interviews were not taped or otherwise recorded verbatim, since the principal investigator firmly believed that, with these sorts of respondents, taping dampened their ability and willingness to be candid. The principal investigator did not want respondents to feel that they were on the record, as respondents were accustomed to dealing with reporters, and when a microphone was in their face, they knew the encounter would be on the record. Notes were taken during the interview, and then written up immediately after; hence, the typescripts of the interviews are labeled "write-up" instead of "transcript." All 247 write-ups have a respondent identification number and the date of the interview on the top of the first page.
The principal investigator also coded the interview write-ups into quantitative data files, despite the nonrandom selection of respondents and the fluid conduct of the interviews. He did this to support quantitative judgments (e.g., "this issue was mentioned frequently in 1978 and not frequently in 1979," or "this factor was hardly ever mentioned in the interviews"). Each interview was coded by two coders, and then their judgments were combined. In addition to generic identifying information, there are two general categories of variables. One category, referred to as "global codes" in the codebook, is composed of ratings of the importance of each of several actors (e.g., mass media, president himself, interest groups, congressional staffers). The other category, referred to as "problem codes" is a coding of the problems that respondents discussed in their interviews, and is divided into health and transportation. A full description of coding procedures is contained in the data collection documentation.
Interview data are supplemented by a series of 23 case studies in health and transportation, and by some attention to other sources of data like congressional hearing records and public opinion data. In addition to various nonquantitative uses of the cases in the study, a quantitative dataset of the case studies was created. Two coders worked independently to judge each of a set of hypothesized influences in the case to be very important, somewhat important, of little importance, or not important. For example, after reading all of the materials for a given case study, a coder would rate the importance of congressional staffers as "very, somewhat, of little, or not" important. In contrast to the interviews, differences between the two coders were not resolved by a combination rule. Instead, the principal investigator and the two coders discussed and reached consensus in each instance in which there had been a disagreement. A full description of coding procedures is contained in the data collection documentation.
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Restrictions View help for Restrictions
This data collection includes both quantitative and qualitative data. The quantitative data files are available to all users. The qualitative data, including scanned typescripts of interview write-ups and a redacted list of respondents (e.g., "civil servant in HEW", or "congressional staffer in transportation"), are restricted from general dissemination. Users interested in obtaining these data must complete an Agreement for the Use of Confidential Data, specify the reasons for the request, and obtain IRB approval or notice of exemption for their research. Apply for access to these data through the ICPSR Restricted Data Contract Portal, which can be accessed via the study home page.
The full list of interview respondents, with names and affiliations, is available only through the ICPSR Data Enclave; the full list of respondents will be made available under restricted access status 30 years after the data are first released by ICPSR.
Distributor(s) View help for Distributor(s)
Time Period(s) View help for Time Period(s)
Date of Collection View help for Date of Collection
Data Collection Notes View help for Data Collection Notes
All interviews were conducted by John Kingdon. The first two waves of interviews (in 1976 and 1977) were all face-to-face, in Washington, DC. In the third wave, in 1978, Dr. Kingdon interviewed those he had interviewed in the previous two waves by long-distance telephone, and went to Washington for face-to-face interviews only for people he had not met before. In the fourth wave in 1979, he interviewed only people he had interviewed before, and therefore conducted all of those interviews by long-distance telephone. Research assistants under his supervision coded the interviews, generated the quantitative data, and produced the case studies and the coding of those cases. A description of the interview process is contained in the data collection documentation.
The principal investigator took great pains to preserve his promise of anonymity to his respondents. At the beginning of each interview, he assured respondents that "none of this is for attribution," which is a standard way to set the ground rules for an academic researcher. That phrase, "not for attribution," meant that he could use quotations from the interviews (as included throughout the published book), but that he would not attribute the quotation to the respondents or identify them except in the most general of terms. The interview write-ups have only an identifying number and date at the beginning of the write-up, not the name or location of the respondent. Users are required to follow these same rules of confidentiality.
Two separate versions of the coded interviews are available in this data collection.
In "Coded Interviews -- Full Categories," subjects are coded into one of seven categories. "Global codes" categories include: (1) Very important, spontaneously mentioned; (2) Very important, discussed in response to question; (3) Somewhat important, spontaneously mentioned; (4) Somewhat important, in response to question; (5) Little importance, spontaneously mentioned; (6) Little importance, in response to question; (9) Not mentioned in the interview at all. "Problem codes" categories include: (1) Very prominent; spontaneously mentioned; (2) Very prominent; in response to a question; (3) Somewhat prominent; spontaneous; (4) Somewhat prominent; response to Q; (5) Little prominence; spontaneous; (6) Little prominence; response to Q; (9) Never mentioned in the interview.
In "Coded Interviews -- Collapsed Categories," subjects are collapsed into one of two categories. For "global codes," categories 1 and 3 are combined into a single category labeled "very or somewhat important," and 2, 4, 5, 6, and 9 are combined into a single category called "prompted, little, or no importance." For "problem codes," categories 1 and 3 are combined into a single category labeled "very or somewhat prominent," and 2, 4, 5, 6, and 9 are combined into a single category called "prompted, little, or no prominence." Almost all of the data analysis in Agendas, Alternatives, and Public Policies is based on this collapsed version of categories.
Sample View help for Sample
This is not a random sample. The selection and proportion of respondents in health and transportation, over the four years of interviewing, and by generic affiliation, is presented in the documentation.
Mode of Data Collection View help for Mode of Data Collection
Original Release Date View help for Original Release Date
Version Date View help for Version Date
Version History View help for Version History
- Kingdon, John W. Agendas, Alternatives, and Public Policies, 1976, 1977, 1978, 1979 [United States]. ICPSR28024-v1. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor], 2011-03-18. http://doi.org/10.3886/ICPSR28024.v1
Data in this collection are available only to users at ICPSR member institutions.
- The citation of this study may have changed due to the new version control system that has been implemented.


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Mary L. Kirk
Funeral services for Mary L. Kirk, 88, of Sweetwater, will be at 11 a.m. on Wednesday, March 13, 1013, at McCoy Chapel of Memories with Rev. Brian Brownlow officiating. A graveside service will follow at 2 p.m. at Texas State Veterans Cemetery in Abilene and interment will follow under the direction of McCoy Funeral Home.The family will receive friends from 6-8 p.m. on Tuesday, March 12, at McCoy Funeral Home, located at 401 East Third Street in Sweetwater.Kirk died Friday, March 8, 2013, at Rolling Plains Memorial Hospital in Sweetwater. She was born Sept. 21, 1924, in Collins County, TX. She married Judge Weldon Kirk on Aug. 17, 1947 in Dallas. She was a member of First United Methodist Church. She was a graduate of Austin College with a teaching degree in education. Kirk lived in Sweetwater most of her life. She also helped on the food committee at the church and was very active in Brownies, Girl Scouts and helping in Boy Scouts. She was also a member of Woman's Forum.Survivors include her daughter, Lisa Kirk of Sweetwater; son, Paul Kirk and wife Louisa of Abilene; brother, Joe Kelley and Dodie of McKinney; grandson, Paul Kirk, Jr. of Tulia; two granddaughters, Kelley Headstream and husband David of Abilene and Jesica McGallain and husband Jeremy of Abilene; grandson-in-law, Joe Fernandez of Abilene; great-grandchildren, Jacob, Caitlyn and Abigail Headstrem, Jaiden, Julia and Nathan McGallian, Faith and Aidan Kirk, Care giver and friends, Dwayne and Barbara Hill and their children, Tiffany and Sammy Ruiz, Midele Stevens and Heather Hill; and Special Friend, Nalona Winnett, all of Sweetwater.She was preceded in death by her husband, Judge Weldon Kirk on July 9, 2009; and granddaughter, Randi Fernandez on Oct. 1, 2012.Pallbearers will be Ted Higginbottom, Bill Kirk, Dwayne Hill, Jeremy McGallian, David Headstream, Pat Bays and Paul Kirk Jr.The family request in lieu of flowers, memorials may be made to the American Cancer Society, 3402 N. 1st, Abilene, TX 79603 or to American Heart Association, 149 N. Willis, Abilene, TX 79603. Online condolences may be expressed at www.mccoyfh.com.


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Historical Books & Maps Search Tips
Historical Books & Maps Last and First Name Search
- When you search both first and last name fields, the search results contain historical books and maps where the surname is "near2" the first name.
- The search engine automatically finds all of the first and last name occurrences that are within two words of each other in the historical books and maps archive.
- When you search both first and last name, it helps the search engine find occurrences of middle names or initials in the old books and maps archive.
- The "near2" search command isn't order specific. This means that your historical books and maps search will retrieve the person's name irrespective of how it is ordered: the last name then the first name or the first name then the last name.
- The historical books and maps search default is intended to return the maximum occurrences of the relative's name you are seeking to find.
- If the ancestor's name you are researching is popular, like Jones, try narrowing your search with some of the options such as location, date range, and keyword. This will create a more targeted query and help the search engine find the specific Jones you are searching for (see below).
Advanced Search Tips for the Historical Books & Maps Database
- There are two keyword search boxes to help target your search for historical books and maps:
- "Include keywords with search" box and "Exclude keywords from search" box (see below).
- Use the Date search box for a specific date or date range of the historical books and maps you are looking for.
How to Search Historical Books & Maps with Keywords and Quotation Marks
- All historical books and maps queries are full-text keyword searches against OCR-generated ASCII text. The complete texts of the old books and maps are scanned against your search query to locate matches.
- Use the "Include keywords with search" box and/or "Exclude keywords from search" box, to expand or narrow your old books and maps search.
- Enclose key phrases in quotation marks, such as "Abraham Lincoln" in the "Include" keyword box to narrow the historical books and maps search to the specific name rather than using the last/first name search that returns search results that match Abraham near2 Lincoln.
- If a large number of names are returned for your historical books and maps archive query, narrow your search by entering names or places that you do NOT want included in your results into the "Exclude" box.
Searching Historical Books & Maps with Boolean Operators
- You can search the historical documents database using Boolean operators like AND, OR, ADJx (order specific), NEARx (order non-specific) and Wildcards (such as "?" and "*").
Expand or narrow your historical books and maps queries
- By clearing populated search fields to expand your query, or by filling in empty search fields to narrow your search query.
You can display historical books and maps results in a multitude of ways, such as:
- Best matches (this is the historical books and maps database search default).
- Oldest items (based on book and map publication dates).
- Newest items (based on book and map publication dates).
- Once the search default is changed, the current selection will remain the default until it is changed again.
Searching Historical Books & Maps by Date Range
- If you know the specific date of the historical book or map you are looking for, use the "Date" search box:
- Enter a specific date or a date range&mdashseveral date formats are accepted.
- Examples: July 4, 1807, or 1807 - 1876, or July 1807 - November 1876.
Search for Old Historical Books & Maps Using Colonial English Variant Spellings
Many of the historical books and maps in the archives database are extremely old, so these searches must account for Colonial English.
- In several Colonial English texts, the long "s" character was nearly identical to the "f."
- If you are looking for old historical books and maps on words containing the letter "s," use the "?" for "s."
- Note: this can occur whether it is the first letter, a letter within a word, or at the end of a word.
- The double "s" in keywords like Missouri should be replaced with two wildcards in historical books and maps searches.
Old Historical Books & Maps Colonial English Query Examples:
|Modern Spelling
|Colonial Spellings
|Suggested Search
|Spani?h, ?pani?h
- In old Colonial American books and maps, type was set was by hand and printers often didn't always have all the type pieces needed to correctly spell a word. These limitations resulted in letters sometimes being omitted from words, or letters that looked similar being used in their place.
- Several of these old books and maps did not use standard spellings.
- Here are a few examples of conventions that were common in old American books and maps:
- Examples of interchanging the use of the letters "i" and "y":
- adjoining - adjoyning
- Pennsylvania - Pensilvania or Penfilvania
- rails - rayls
- Use of name variants: Smith or Smythe
- Use of "e" in word endings: Chesapeake or Chesapeak
- Dropping the letter "h": Philadelphia or Philadelpia
- Examples of irregular vowel usage:
- clerk - cleark
- color - colour
- Delaware - Deleware
- Elijah - Elifha
- Israel - Ifreal - Ifral
- Jehovah - Javovah
- Examples of adding the letter e to word endings:
- Brown - Browne
- Chesapeake - Chefopeak or Chefopeake
- Clark - Clarke
- highways - highwayes
Colonial American Books & Maps Search Notes:
- Use wildcards such as the question mark "?" or the asterisk "*" in your colonial books or maps searches.
- A question mark is a single-character wildcard and an asterisk is a multi-character (allows for up to 5 characters) wildcard.


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- November 15, 2012
- 4.5m Views
- Immortal
Dave FrancoWriter/Actor
Chris Mintz-PlasseActor
Brian McGinnDirector/Producer/Editor
Rod BlackhurstDirector/Producer/Editor
Funny Or DieUploader
Talia TabinActor
Funny or Die MoviesChannel
Hall of FameChannel
Directed, Produced & Edited by ROD BLACKHURST & BRIAN McGINN
Written & Produced by DAVE FRANCO
Starring DAVE FRANCO, TALIA TABIN, BETSY FRANCO & CHRISTOPHER MINTZ-PLASSE
Director of Photography | GARETH PAUL COX
Colorist | SANTIAGO PADILLA or New Hat
Executive Producer | ERIC HOLLENBECK & PAUL KRIZAN
November 15, 2012
CategoryNot Safe For Work Sketch
[Music Playing]
Talia Tabin: How bad?
Dave Franco: Not good. After two beers I am foul drunk right now. [Laughs]
Talia Tabin: You're getting there.
Dave Franco: [Laughs] Um, okay. All right, all right, all right, I got one.
Talia Tabin: Okay, start.
Dave Franco: [Burps]
Talia Tabin: Ugh! I am done with that game. I am done with that game. Have I told you that?
Dave Franco: Okay. All right, all right. Would you rather have a penis...
Talia Tabin: Mhm.
Dave Franco: Or, uhm...
Talia Tabin: Wait, what kind of penis? Uh, is this like a Jessie Miller type penis?
Dave Franco: Oh, stop it! Jesus!
Talia Tabin: Is it a really nice penis?
Dave Franco: Stop! Your boyfriend has a big 'ol dick, we get it!
Dave Franco: Or, uh, relive your prom night? Taking the stage and just belting your little heart out to Hakuna Matata. [Laughs]
Talia Tabin: I want the penis!
Dave Franco: I would, too. I would, too! [Laughs] What is it? [Singing] Hakuna Matata, it means be responsible! For the rest of the niiiight!
Talia Tabin: Okay.
Dave Franco: [Laughs]
Talia Tabin: Okay.
Dave Franco: Student body president dork.
Talia Tabin: [Sighs] Serious question.
Dave Franco: 'Kay.
Talia Tabin: Serious one.
Dave Franco: Sounds serious.
Talia Tabin: Would you rather watch while your dad fu**s your mom doggy style...
Dave Franco: Serious one. Okay. I like it.
Talia Tabin: Serious one! And they're both staring into your soul. Just staring into your eyes.
Dave Franco: Doin' it. Cool. Cool. I'm with you. What's the other fu**in' option Jesus Christ.
Talia Tabin: Or, jerk off to a picture of your mom while she watches you?
Dave Franco: Who fu**ing says that? [Coughs]
Talia Tabin: Choose!
Dave Franco: Uh, the jerk off one I guess?
Talia Tabin: Oh!
Dave Franco: Don't give me that face!
Talia Tabin: Oh! Wrong choice!
Dave Franco: Right, that is the wrong choice. That was bad, right? [Laughs]
Talia Tabin: That's the wrong choice!
Dave Franco: That was worse than the other one, right?
[Music Playing]
Dave Franco: Ah, wha..oh! Oh, what?! Oh God! Oh, uhh!
Betsy Franco: Oh! Stop it sweetie!
Dave Franco: Oh! Ahh! Why?! Uh! I can't! I can't stop! Oh fu**!
Talia Tabin: Wake up.
Dave Franco: Oh! Why?!
Talia Tabin: Wake up! Wake up!
Dave Franco: [Gasps]
Talia Tabin: You're okay.
Dave Franco: No. Whoa! No!
Talia Tabin: What's going on?
Dave Franco: What's going on?! I just sex, I just jacked off to a picture of my mom, while she watched!
Talia Tabin: No. That was the game.
Dave Franco: No, no, it was not the game. Don't laugh. Please don't laugh.
Talia Tabin: You're fine. Relax. You're freaking me out.
Dave Franco: Okay. Okay. All right. Just, look, I want you to get where I'm at. Okay? I want you to understand what I'm going through. You ready? Let's, let's just play with you. Let's do your turn. Okay?
Talia Tabin: Sure.
Dave Franco: Okay. All right. You ready? Okay. Would you rather uhm, have Jessie Miller's teeth...
Talia Tabin: Jessie Miller again, huh? Really? Really?
Dave Franco: Barely even notice that dead tooth of his. Kay, that's the first one. All right? Next one, all right, are you ready? Okay. Or, uhm, have sex with, uh, Chris Mintz-Plasse? Have sex with Chris Mintz-Plasse.
Talia Tabin: That's interesting.
Dave Franco: Ah, okay.
Talia Tabin: Well, you've seen him in those tights in that Kick Ass movie.
Dave Franco: Oh my God why doesn't it surprise me that you like the dorkiest fu**ing guys?
Talia Tabin: Is it dorky to kick ass?
Dave Franco: Ugh! Never!
[Music Playing]
Chris Mintz=Plasse: Oh. Ah.
Chris Mintz-Plasse: Daddy is enjoying this. Mmm.
Talia Tabin: [Gasps] [Whispering] What the f**k? [End Whispering] What the f**k?!
Dave Franco: Told you.
Dave Franco: All right, no, look. I got it though. All right? I figured it out, okay? Look, just give me one. Give me one.
Dave Franco: No, no no. Look, look. Give me like, two like, amazing options, all right? Things I would want to do. All right? You get it?
Talia Tabin: Oh my God.
Dave Franco: Yeah, yeah, yeah. We can do whatever we want!
Talia Tabin: Okay.
Dave Franco: Yeah, yeah, yeah. Just give, give, just give fu**in', make my dreams fu**ing come true, all right? Give it!
Talia Tabin: I have one!
Dave Franco: You got. Already? Okay, let's do it!
Talia Tabin: Would you rather...
Dave Franco: Let's do it.
Talia Tabin: Have Allie take you back...
Dave Franco: What? Whoa.
Talia Tabin: Is that bad?
Dave Franco: It just, it doesn't seem to be getting through to you, I'm fu**ing, I'm done. All right? I'm done with that. This isn't, this isn't one of my, like, you know, uh, yeah! You know I think I'm really, this is it, I'm done. I'm done! Okay?! Get that s**t out of here, all right? Don't. That's your one amazing...
Talia Tabin: I'm sorry.
Dave Franco: option?! Give, what's the other? Give it! Give it! All right. Something you know I'd love. You know me.
Talia Tabin: Or [Whispers] Kiss me.
Dave Franco: Wha?
Talia Tabin: [Sighs] Nothing. Never mind. That was...Sorry.
Dave Franco: What, what about Jessie?
Talia Tabin: You were with Allie. Or Nicole. Or Jen. Oh, I feel so stupid. Just forget it.
[Music Playing] [Kissing Sounds]
Talia Tabin: Why Chris Mintz-Plasse?
Dave Franco: Uh, is it weird to say that I know he'd be gentle?
[Both Laughing] [Kissing Sounds]
Talia Tabin: Would you rather...
Dave Franco: Mmm.
Talia Tabin: F**k me right now...
Dave Franco: Ohh!
Talia Tabin: Or make sweet, sweet Mintz-Plasse love to me?
Dave Franco: Oh, yeah! Give me that second one!
Talia Tabin: [Giggling]
[Kissing Sounds] [Music Playing]
[Air Horn Sound]
Talia Tabin: I want the penis!
Dave Franco: Oh f**k!
[Music Playing]


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Shortly after Christmas, I had set aside the remaining half of a bar of almond paste that I used to make an Easy German Stollen-- I was waiting for an excuse to use it. I had good fortune, when one of my favorite blogs that I follow, "2 Stews", posted a recipe for a Cranberry Almond Pound Cake. As I began to read the ingredients list, I was pleased to know that I had frozen cranberries (I always keep a few bags of fresh cranberries in our freezer, since they're a seasonal item). I also saw that this recipe uses Amaretto liqueur, which is a staple in my pantry. I started to feel my pulse race, when I saw that sour cream is used in the batter, because I love the subtle tang and moisture that it gives to cake recipes. I could almost taste a winning combination of ingredients, and I made the decision to shut down my laptop and bake this-- pronto! I had everything I needed:
Baker's Joy Non-Stick Spray. Of course you can use good old flour and shortening, but I've never had a bundt cake disaster, ever since I stocked up on this fantastic baking product.
LorAnn Almond Bakery Emulsion, because the flavors aren't lost in the baking. (I also use LorAnn Buttery Sweet Dough Flavor in most of my cakes... I love them!) Of course, you can use pure almond oil-- and if you don't like almond, then use vanilla.
The cake is very moist, and just a little dense-- but not over-the-top. The flavor of the almonds, I think, could be increased by adding more almond extract. But remember, I'm a lover of anything almond. I think dried cherries could be used, or really any kind of fruit. Would I make this again? You bet! My family and friends approved of this recipe. I think you will, too.
Like most of you, I subscribe to a lot of foodie magazines, and I buy more than my fair share of cookbooks. I just love it when I find a recipe that a fellow food blogger has shared, and it delivers as promised. Thanks, 2 Stews, for sharing this delectable cake!


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Ahhh Spa for teens April 27
After this tough winter, who isn't up for a spa treatment? Teens can pamper themselves at Ahhh Spa on Sunday, April 27, from 1 p.m. to 3 p.m. at the Fond du Lac Public Library.
Teens in grades six to 12 are welcome for an afternoon with the experts from Renaissance Salon, who'll share tips and help. Teens will make a facial scrub to take home and will receive other products to refresh the skin and welcome spring.
The event is free, no registration required.


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Degree Requirements
B.A. in Business, Management ConcentrationThe Management concentration combines classroom work in technology, theory and accounting with research and an internship to prepare you to run a small business or manage a corporate department.
A.S. in ManagementThis two-year program prepares you for front-line managerial positions as well as a strong foundation to continue in the B.A. degree program at JSC.
Certificate in Small Business ManagementDesigned for business owners and employers, this program focuses on management functions more than operational techniques.
Our graduates have gone on to found and operate large and small businesses, both in Vermont and worldwide. They launch cutting-edge ventures, help existing companies grow and succeed, and manage complex organizations with global reach.
Related Occupations
- Banker
- Insurance agent
- Human resources manager
- Administrator
- Sales representative
- Accountant
- Bookkeeper
- Financial Planner
- Information technology specialist
- Marketing director
- Advertising agent
- Public relations specialist
- Teacher or instructor
Types of Employers
- Banks and financial institutions
- Retail stores
- Restaurants
- Hotels and other facilities
- Service providers
- Healthcare organizations
- Manufacturers
- Software and technology companies
- Educational institutions
- Local, state, and federal government
- Nonprofit organizations
- Self-employed


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NRA's LaPierre: 'Let them be damned!'
Unloads on political, media 'elites' for 'illogical' solutions to gun violence
Wayne LaPierre, the CEO of the National Rifle Association, let loose against the media and government who have recently characterized the gun lobbyist's talking points as "crazy."
"Let them be damned!" roared LaPierre.
In a speech at the Conservative Political Action Conference, LaPierre accused gun-control advocates of offering "illogical" solutions to the problems of gun violence.
"They denigrate, and they call us 'crazy' for holding fast to [our opposition to gun control]. In their distorted view of the world, they're smarter than we are; they're special; they're more worthy than we are; they know better than we do," he said. "The liberal media can keep hating on me, but I'm still standing."
LaPierre dismissed the Obama administration's efforts to curb gun violence as ineffective and an infringement on Second Amendment rights. He described Democrats' calls for expanding background checks as a "placebo" to which criminals won't submit.
"There are only two reasons for government to create that federal registry of gun owners, to tax them or to take them," LaPierre said.
LaPierre reserved his harshest criticism for Janet Napolitano's Department of Homeland Security, which suggested in a recent Web video that citizens use objects like scissors when faced by an active shooter.
"Scissors? That's their answer?" LaPierre exclaimed. "To protect our children at school, we recommend a trained professional with a gun, and they recommend scissors? And they say we're crazy? It's sheer madness."
LaPierre has been the public face of the NRA in the wake of the mass shooting last year in Newtown, Conn., in which 20 children and 6 adults were shot and killed in an elementary school. He used his speech to once again express his support for putting armed guards in schools across the country.
"There's not a mom or a dad anywhere who wouldn't feel safer seeing a police car in parking lot when they drop their kids off to school," he said.
He also blasted the "political advice" from "elites" in government who have proposed unconventional defense methods for women facing attacks.
LaPierre mocked Vice President Joe Biden for his advice that women fire a shotgun into the air if confronted by an attacker.
"Honestly, have they lost their minds over at the White House?"
The crowd cheered in approval.
"Keep your advice, we'll keep our guns," LaPierre concluded. "The one thing a violent rapist deserves to face is a good woman with a gun."


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ARC & NHMRC Survey of Research Commercialisation, Year Ending December 2000
F. Respondent Load
On average, how long will a respondent be expected to spend in completing each questionnaire? How has this estimate been derived? Will the time taken by respondents to complete the survey be recorded? (F1)
Return to top
What steps have been taken to reduce the burden on small businesses, eg use of a reduced questionnaire? (F2)
Return to top
What commitments have been made to preserve the confidentiality of respondents? How will these be implemented? (F3)


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The Durango High School track and field teams ran, jumped and threw their way to impressive results Saturday at the Mickey Dunn Invitational in Grand Junction and Piedra Vista Invitational in Farmington.
The DHS girls team won the title by a point, 82-81, over Grand Junction at the Mickey Dunn Invitational, while the boys finished third, 16 points behind champion Eagle Valley and three behind runner-up Glenwood Springs.
The Durango boys sent most of their jumpers to the Piedra Vista Invitational, and a small contingent from the girls team joined them.
Devin Lewis paced the DHS sprinters at the Mickey Dunn Invitational, winning both the 100- and 200-meter dashes and finishing second in the 400. He also ran the opening leg, head coach David McMillan said, of the 4x400 relay team, which won in 3 minutes, 34.34 seconds to move into fourth place this season in all of Class 4A.
"Devin Lewis ran superbly," McMillan said in an email.
The Maloney siblings turned in a typically strong performance in the distance events. Shannon Maloney won the 800 in 2:22.46, while brother Joe Maloney won the same event in 2:01.39. Joe Maloney also participated on the victorious 4x400 relay, along with Trent Andrews and Shane Bisogno.
"The stiff headwind slowed times considerably, but the strong performances placed both on the Colorado leaderboard," McMillan said.
Gabi Razma set a personal best to finish third in the triple jump, coming in at 17 feet, 0.25 inches, which McMillan said could end up landing her at state, given the results in recent years, and Miranda Gallegos was fifth at 15-10.75. Razma also was third in the long jump at 33-8.75.
Austin Miles picked up a win in the shot put with a throw of 49 feet, 2.75 inches, and he was fourth in the discus with a season-best of 121-3. On the girls side, McKenna Franzen tossed a season-best 36 feet to finish in fourth.
The DHS girls relay teams shone brightly, as well. Hannah Hwang, Natalie Neeve, Mackenzie Sill and Dominique Ward won the 4x200, while Neeve, Ward, Madeigh Winsor and Emily Fogel captured the title in the 4x400. The sprint medley relay of Hwang, Neeve, Shannon Maloney and Shanelle Bogus were second. Gallegos, Fogel, Winsor and Katarina Seibert were second in the 4x800, as well.
At the Piedra Vista Invitational, Gabe Gilliland won the high jump at 5 feet, 10 inches with Dane Mestas in third at 5-8. Gilliland also was fourth in the pole vault at 10-6.
The DHS 4x400 boys relay of Justin MArcum, Sebastian Foltz, Vicente Jimenez and David Moening was fourth, as was the sprint medley team of Joaquin Valdez, Bryan Dunlop, Seamus Milliet and Moening.
Nona Patcheck finished fourth in the girls high jump at 4-8, and the 4x400 relay team of Hope McCraw, Amy Raulston, Mariah Dorsey and Shi Thompson finished fifth.
The Demons will be in Broomfield for the Broomfield Shootout on Saturday.


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Conference Primers: #26 – SouthlandPosted by rtmsf on October 11th, 2007
Predicted Order of Finish:
- Lamar (18-11) (11-5)
- Northwestern St. (19-11) (11-5)
- McNeese St. (14-15) (8-8)
- Nicholls St. (10-19) (7-9)
- Southeast Louisiana (9-19) (5-11)
- Central Arkansas (7-20) (4-12)
- Sam Houston St. (20-9) (12-4)
- Texas – Arlington (19-9) (11-5)
- Texas A&M – Corpus Christi (14-13) (10-6)
- Stephen F. Austin (14-15) (8-8)
- Texas St. (8-20) (6-10)
- Texas – San Antonio (7-23) (3-13)
WYN2K. On its surface, the Southland appears to be an improving league. Over the last three seasons, the league has won progressively more games against OOC D1 opponents (26/33/41) for an overall record of 100-212 (.321) during this period. Additionally, while the league has been a #16 seed in six of the last eleven NCAA Tourneys, it has earned a higher seed five of the last six years (#14/#15/#16/#15/#14/#15). The #14 seed in 2006 (Northwestern St.) paid off with one of the biggest upsets of that year's tournament, as the Demons defeated #3 Iowa 64-63 in miraculous fashion (see below). We think that the competitive balance among the top of the league this year will allow the Southland to continue to earn a higher seed than #16.
Predicted Champion. Sam Houston St. (#15 seed NCAA). There are five teams who we figure can win this league, but out of the group, we like SHSU's experience returning along with POY candidate Ryan Bright. Bright is a stat sheet stuffer extraordinaire – he finished in the top 250 players nationally last year in several categories, including eFG% (183), dReb% (120), blocks% (161) and steals% (178). The Bearkats were poised to challenge Texas A&M-CC last year before a first-round conference tournament upset at the hands of Lamar.
Others Considered. Texas-Arlington is a rising program, returning everyone of consequence from a team that won eight of its last eleven games last year. Still, we're not completely sold on a team that had a losing record (13-17). Lamar is another intriguing team, as they return four starters and have brought in a couple of juco PGs to battle over that position, but again, they only went 15-17 last year. Texas A&M – Corpus Christi lost nearly everyone from a team that gave Wisconsin a huge scare last year in the NCAAs (Tx A&M-CC was up 25-7 at one point), but the one key player they return (7'0 Chris Daniels) was last season's conference POY and tournament MVP. Northwestern St. can't be counted out either, as they always seem to find themselves in the conference mix, having been to five of the last eight Southland title games.
Games to Watch. Again, only one Southland game will be on the national radar.
- Southland Championship Game (03.16.08). ESPN2.
RPI Booster Games. The Southland hasn't shied away from scheduling BCS teams, with 34 on the agenda this season. Last year the conference defeated three BCS bottom-dwellers (Texas A&M – CC over South Florida; SE Lousiana over Oregon St. and Penn St.), and there are some similar opportunities this year.
- Northwestern St. @ Stanford (11.10.07)
- Texas Tech @ Sam Houston St. (11.14.07)
- Lamar @ Mississippi (11.16.07)
- Northwestern St. @ LSU (12.15.07)
- Mississippi St. @ Texas A&M – CC (12.21.07)
- Texas A&M – CC @ Auburn (01.02.08)
Odds of Multiple NCAA Bids. Slim to none. Had Texas A&M-CC not lost just about everyone, we could have made an argument for their inclusion as an at-large and likely 26-4 team, but that's not the case. This is a one-bid league.
Neat-o Stat. Nicholls St. apparently believes in
stomping on its players' throats and eviscerating their spleens trial by fire, as its nonconference schedule last year was rated #17 by Pomeroy and it is on target for that level of difficulty again. Last year the Colonels played Mississippi St., Northern Iowa, Washington, Pepperdine, LSU, Texas, Ole Miss, Auburn and Vanderbilt, losing every game. This year NSU will play the likes of Florida St., California, LSU, Alabama, UNC, Minnesota and UNLV – all on the road, all before the new year, and all likely Ls. Hard to build much confidence that way.
64/65-Team Era. The Southland is 4-23 (.148) in the era, but those four wins are a little misleading – two of the wins were from Karl Malone's Louisiana Tech team in 1985 that went to the Sweet 16, and one of the wins is from the PiG in 2001 (Northwestern St. defeated Winthrop 71-67). The only other first-round win was mentioned above – Northwestern St. over Iowa in 2006.
We'll Take Any Excuse to Bust Out this Pic
Final Thought. The champion of this league is a team to watch next March. Last year, Texas A&M – CC gave Wisconsin all it wanted for 30 minutes. The previous year we know what happened to Iowa at the hands of Northwestern St. And in 2005 #2 Oklahoma St. struggled against #15 SE Louisiana before pulling away to win 63-50. The championship-caliber teams that come out of this league can play, especially against the Big 10 (it seems)!


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Animals in the News
by Gregory McNamee
Why should it be that the Maine Coastal Islands National Wildlife Refuge is seeing a 40 percent decline in the number of Arctic terns passing through its confines in the last ten years? You know why, and I know why, though reportedly some 160 members of Congress do not: Climate change is affecting every corner of our world. The tern's world is changing, too, for its favored prey, the herring, is moving to colder waters. So, after flying 14,000-odd miles from the Antarctic, the terns now find themselves without sustenance. Given that most migratory creatures have adapted to particular habitats over long periods of time, they are the most vulnerable of all animals to climate change. So reports a new study by the National Wildlife Federation, available here. For testimonial to that, we only have to look in the Gulf of Maine. QED.
* * * …


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Written by Austin Benson Thursday, 22 August 2013 15:17
County commissioners okay lottery request
The Nebraska Barn and Grill, a restaurant scheduled to open in Gothenburg the first week of September, wants to offer Keno in the bar area.
At a Dawson County Commissioners meeting last Thursday, the restaurant received approval to provide the lottery game.
With commissioner approval, the request was sent to the Nebraska Lottery offices in Columbus. If the bid is approved, Nebraska Barn and Grill can offer Keno.
In other business, a deed of conservation easement agreement was made between Wetlands America and Darr Farms, LLC.
John Cunningham, a Wetlands America representative, said his company was seeking a 250-acre area in Dawson County for rural conservation.
There would be a small area taken out of the easement for a cabin to be placed on the land, he said.
There are no crops on the property, which would remain the same, and it would be grazed periodically, Cunningham said.
In other business, Olds Cork & Cap Liquor in Cozad was granted a special designated license to serve liquor at a wedding Sept. 14 in rural Cozad.
In other business, the board:
authorized chairman P.J. Jacobson to sign a sub-grant agreement for Child Support Enforcement Services.
issued a U.S. Bank purchase card for county surveyor Mark Streit.


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The Check Your Symptoms tool in our Health Library lets you use a mouse to select a part of the body and the type of information you are looking for. You can then select the appropriate link to get more information.
UPMC's Department of Family Medicine has several locations throughout the city of Pittsburgh and Allegheny County.
Find a family medicine health center close to you and call us to make an appointment or find out how we can help you with your primary care needs.
Affiliated with the University of Pittsburgh Schools of the Health Sciences
| Supplemental content provided by Healthwise, Incorporated. To learn more, visit www.healthwise.org
For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.
UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, gender identity, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.
Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.
Pittsburgh, PA, USA | UPMC.com


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Four Points Best Brews
Kick back and relax after a long day on the road with a great craft beer. Our Best Brews® program features unique offerings, some locally sourced, all straight from the tap at Four Points. Each season the Best Brew program is enhanced with seasonal offerings, like Summer Ales, Oktoberfest & Winter Ales. Taste your way through your travels and savor a collection of beer experiences to take home after your time on the road. Cheers!
Join us each Wednesday in the lobby from 6 - 7:30 PM and sample our current Best Brews offering, Drop Top Amber Ale.


text:
Reuter's London 2012
Reuters, the news and media division of Thomson Reuters and the world's largest international multimedia news provider, needed a complex white label Web Content Management System (CMS) to support their Olympics Website, Mobile Olympics Site, and Content Support for iPad and iPhone applications. Rich and timely content curation, along with ease of use for the Reuters' on-the-ground journalists and editors was a critical component to the success of the project.
What We Did
Through the development of a high powered Drupal platform, Phase2 enabled Reuters to take their web news coverage of the Olympics to the next level. Reuters needed a content-centric platform, not just a website, that could support the substantial and timely needs of the Reuters' Olympic news desk. A sophisticated platform was needed for a constant flow of multimedia coverage, including stories, photos, and video, that could easily be added to the website in order to support the huge journalistic presence of Reuters at the 2012 Summer Olympics in London.
Key Features included
- Customized and flexible workflows to match the Reuters web news desk
- Full integration with Olympics sports data, including medal counts, schedules, participating athletes, and venue information
- Single point of editorial curation driving content on multiple platforms, including desktop web, mobile web, and iOS applications


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GOP: Quinn Delaying Checks Of Medicaid Eligibility
SPRINGFIELD, Ill. (AP) – Republican leaders accuse the Quinn administration of dragging its feet on a new effort to make sure Medicaid goes only to people who qualify. But they also acknowledge the governor has hit a key target date.
Illinois wants to keep a closer eye on Medicaid to ensure the health care program is only used by people who meet eligibility requirements. Gov. Pat Quinn was given 90 days to hire a company to conduct the reviews.
Quinn met that deadline but says the company needs three months of preparation before it starts.
Republican legislative leaders Christine Radogno and Tom Cross said Monday that Quinn is taking too long. They want eligibility reviews to start in two weeks so Illinois can save as much money as possible.


text: As time goes by, it seems that I get less days with my kids on the water so, when my daughter said "Dad I have Friday off, want to go fishing?" It didn't take much for a yes. I've been down after the gators a few trips in the past couple weeks so I already knew the season was running a little behind or maybe just slow. It didn't matter really because today was about father daughter time. As I expected, it was still slow down there, we decided to give it to 1:00. As is often the case, we ran a little over so, at about 1:15 my daughter says "well, it's past 1:00 dad?" So with that we all get up and head to the poles. Before we get to the poles I look and my daughter's pole is getting a bite. So one good hook set and the fight is on. She's fighting the fish about 5 min. Then she says she's getting hot, will I hold the pole for a second. Then the battle continues after she sheds a layer. Another 10 minute, "hey dad can you hold this again for a second?" Another layer shed and the battle continues. By now I think Kodi(my Lab) realizes this is gonna take awhile. The battle continues..... Another 15 minutes and some coaching from good ol' dad. "OK girl quit showboatin' takem to the mat." " OK dad." Well, we stayed a couple more hours with no results. Didn't matter, she got her fish and all I had to do was pull the hook. Best day this season.....for dad.


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Most of the people find it difficult very to lose weight through different weight loss procedures. They find it difficult to resort to medications as they know that the weight loss pills or medicines are sure to result in side effects. However if folks are committed to shed extra pounds they can do it despite the odds. But most often these odds and tight schedule deter folks from consistently continuing weight loss efforts. For such a situation I have got some really easy weight loss ideas.
First of, you need to control your diet. Dietary measures could be easily adopted as you know what adds greatly to weight. You should simply refrain from high fat foods and rather rely on fiber products. This life style change could be easily embraced if you have even a bit of realization about consequences that you may face in case of an uncontrolled weight gain.
diets for weight loss, diet solution program review, loose weight,
Along with dietary restriction you can easily take up exercise to shed weight. If you are running short of time, buying home a treadmill would help you shed weight in no time. This is the easiest option of losing weight in lesser time.
Whenever you feel the urge to eat, instead of solid food you should better drink water for satiety. You must try to know about the calorie of all your food intakes, it would help regulate your food intake as per your calorie requirement.
If it is not possible for you to do workouts on treadmill, you must ensure half an hour walk every day. There couldn't be better substitute of walking every day in order to reduce weight. For an extreme case of weight gain it is rather suggested to take up jogging. Although walking and jogging are not easy options for many.
Minimize duration of your sitting works and try to keep yourself physically active even while doing something that requires concentration. Folks having a sitting nature of job are more prone to excessive weight gain. By allowing themselves to be physically active after the job hour, they could lose weight to remain fit.
Keep all stress and tensions at bay and stick to dietary and exercise measures with a positive frame of mind. It would be of great help in lowering your weight.
You must also avoid junk food. Increase intake of vegetables and fruits. You must not skip your dinner for this. As, many obese people have been caught with this habit. You must know that skipping doesn't offer a solution to your obesity instead it works adversely and inhibits your weight loss efforts.
These are some of the easy ways of weight loss. You can resort to them without seeking help of anybody.


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Judge: Gene Patents Are Invalid
from the huge-news dept
"are directed to a law of nature and were therefore improperly granted."The case was brought against Myriad Genetics, who will surely appeal, so this is nowhere close to over. But it involved a test for breast cancer, that Myriad basically had a monopoly over -- and the claim was that this not only made it more difficult for women to get tested, but it also greatly discouraged other research in the field. In part, this was because the patents that Myriad held were incredibly broad.
Patents, of course, are not supposed to be granted on things found in in nature -- and it's hard to argue against the idea that genes are found in nature. Supporters of gene patents often claim that they're not really gene patents, but a patent on identifying the gene, which is a nice semantic game that the judge clearly saw through. This is a huge step forward for encouraging more real research into genetic testing, rather than locking up important information.


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Jackson's Way: Andrew Jackson and the People of the Western Waters
Wiley, Jan 22, 2001 - History - 448 pages
Praise for Jackson's Way
"A compelling account of Jackson's Indian-fighting days . . . as well a grand sweep of the conquest of the trans-Appalachian West, a more complex, bloody, and intrigue-filled episode than is generally appreciated. . . . Mr. Buchanan writes with style and insight. . . . This is history at its best."
-The Wall Street Journal
"An excellent study . . . of an area and a time period too long neglected by historians . . . provides valuable new information, particularly on the Indians."
-Robert Remini, author of Andrew Jackson and His Indian Wars
"John Buchanan has written a book that explodes with action and drama on virtually every page. Yet the complex story of the birth of the American West never loses its focus-Andrew Jackson's improbable rise to fame and power. This is an American saga, brilliantly told by a master of historical narrative."
-Thomas Fleming, author of Duel: Alexander Hamilton, Aaron Burr, and the Future of America
From John Buchanan, the highly acclaimed author of The Road to Guilford Courthouse, comes a compulsively readable account that begins in 1780 amidst the maelstrom of revolution and continues throughout the three tumultuous decades that would decide the future course of this nation. Jackson's Way artfully reconstructs the era and the region that made Andrew Jackson's reputation as "Old Hickory," a man who was so beloved that men voted for him fifteen years after his death. Buchanan resurrects the remarkable man behind the legend, bringing to life the thrilling details of frontier warfare and of Jackson's exploits as an Indian fighter-and reassessing the vilification that has since been heaped on him because of his Indian policy. Culminating with Jackson's defeat of the British at New Orleans-the stunning victory that made him a national hero-this gripping narrative shows us how a people's obsession with land and opportunity and their charismatic leader's quest for an empire produced what would become the United States of America that we know today.
What people are saying - Write a review
JACKSON'S WAY: Andrew Jackson and the People of the Western WatersUser Review - Kirkus
A level, intelligent, and thoroughly readable biography of Old Hickory, from historian Buchanan (The Road to Guilford Courthouse, not reviewed).Though no revisionist, Buchanan does try to put Jackson ... Read full review
LibraryThing ReviewUser Review - LeahsChoice - LibraryThing
If you're looking for a book on Andrew Jackson, this isn't the one you'd want. There's actually little about Jackson in this book. It focuses mostly on the people and their problems of that era. It's interesting and well written, but the title is not an accurate representation of the contents. Read full review
Other editions - View all
Jackson's Way: Andrew Jackson and the People of the Western Waters
John Buchanan
No preview available - 2003
Common terms and phrases
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Researcher Sonia Chernova, who's currently doing a postdoc with Cynthia Breazeal at the Personal Robots Group at the MIT Media Lab, wrote in to let us know about a new online game to study human interactions.
In the game called Mars Escape each player can take on the role of an astronaut or a robot on Mars, who must work together to complete various missions before oxygen runs out. In the current first phase of the study the researchers study how human players work as a team. In a second phase later this year the researchers will use the data collected from human players to build a model of how they interacted for task assignment, action synchronization, and problem solving. The model will then be tested by creating an in-game AI.
The long-term goal of the project is to create robots that are able to assist and work with humans in a natural, predictable and robust way. To this end, the researchers will recreate the game environment in real life this summer at the Boston Museum of Science, and test their behavior model using their MDS robot Nexi.
Check out the game!


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Sarah Boden
|Kilkeel, Northern Ireland
|High School:
|St. Louis
2012-13: Played in all 20 rounds for the Blue Devils in 2012-13 as a freshman...Her best finish came at the Valparaiso Spring Invitational where she placed fifth...Third on the team in scoring average with an 82.9 average on the year over 1,658 strokes...At the 2013 Northeast Conference Championships, she placed tied for 23rd...Shot a career low 73 in the third round of the St. John's Intercollegiate.
Before Central: Boden won the PING Young Masters All-Ireland Girls Title in 2007...She was also a member of the Under 15 Ulster Girls team that won an All-Ireland title...During her time with The Royal Co. Down girls team, she helped lead her team to an Ulster Title in 2009 while placing runner-up in the All-Ireland Title.


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Soligenix Submits BARDA Contract Proposal for Development of OrbeShield™ in GI ARS
Feb 20, 2013, 07:00 EST
PRINCETON, N.J., Feb. 20, 2013 /PRNewswire/ -- Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the Company), a development stage biopharmaceutical company, announced today submission of a full contract proposal to the Biomedical Advanced Research and Development Authority (BARDA) Division of Chemical, Biological, Radiological and Nuclear (CBRN) Medical Countermeasures. This submission supports a potential multi-year, multi-million dollar contract to develop OrbeShield™ (oral beclomethasone 17,21-dipropionate or oral BDP) as a medical countermeasure (MCM) for the treatment of gastrointestinal acute radiation syndrome (GI ARS).
Soligenix was invited to submit this proposal following a review of its white paper entitled "OrbeShield™, oral beclomethasone 17,21-dipropionate (BDP), a candidate broad spectrum therapeutic countermeasure for GI ARS," to BARDA in response to a Broad Agency Announcement (BARDA-BAA-12-100-SOL-00011) for advanced research and development of MCMs for chemical, biological, radiological and nuclear threats. BARDA is interested in the advanced development and eventual licensure/approval of effective MCMs that mitigate, treat, affect, delay, or interrupt the progression of injuries resulting from acute exposure to radiation from a nuclear accident or attack.
In a canine model of GI ARS, OrbeShield™ demonstrated a statistically significant survival advantage in animals that received OrbeShield™ therapy up to 24 hours following exposure to lethal doses of total body irradiation when compared with placebo-control animals (p=0.04). Median survival following irradiation in the control group was 8 days, compared to 87 days in the OrbeShield™ treated group. This work was largely supported by a $1 million grant to Soligenix's academic partner, the Fred Hutchinson Cancer Research Center, from the National Institute of Allergy and Infectious Diseases (NIAID).
A subsequent study to replicate and expand upon the observations made in the canine model is ongoing and is supported by a $600,000 Small Business Innovation Research (SBIR) grant award from the NIAID.
"We are excited about the contract proposal submission to BARDA," stated Christopher J. Schaber, PhD, President & Chief Executive Officer of Soligenix. "Although there are no guarantees, we believe that we are well-positioned to receive BARDA development support for this indication allowing us to further demonstrate the growing body of compelling scientific evidence supporting OrbeShield™'s potential as a countermeasure for GI ARS. Having recently received Orphan Drug and Fast Track designations from the FDA, we look forward to continued productive interactions with BARDA, NIAID and FDA as we move the OrbeShield™ GI ARS development program forward."
The submission of our proposal is non-binding and does not guarantee the award of a BARDA contract. The contract award will require a favorable technical and scientific review by BARDA followed by negotiation of fair and reasonable contract terms.
About GI ARS
ARS occurs after toxic radiation exposure and involves several organ systems, notably the bone marrow the GI tract and later the lungs. In the event of a nuclear disaster or terrorist detonation of a nuclear bomb, casualties exposed to >2 Gy are at high risk for development of clinically significant ARS. Exposure to high doses of radiation exceeding 10-12 Gy causes acute GI injury which can result in death in 5-15 days. The GI tract is highly sensitive due to the requirement for incessant proliferation of crypt stem cells and production of mucosal epithelium. The extent of injury to the bone marrow and the GI tract are the principal determinants of survival after exposure to TBI. Although the hematopoietic syndrome can be rescued by bone marrow transplantation or growth factor administration, there is no established treatment or preventive measure for the GI damage that occurs after high-dose radiation. Therefore, there is an urgent need to develop specific MCMs against the lethal pathophysiological manifestations of radiation-induced GI injury.
About OrbeShield™
OrbeShield™ is formulated for oral administration in GI ARS patients as a single product consisting of two tablets; one tablet releases BDP in the proximal portions of the GI tract and the other tablet releases BDP in the distal portions of the GI tract. BDP has been marketed in the United States and worldwide since the early 1970s as the active pharmaceutical ingredient in inhalation products for the treatment of patients with allergic rhinitis and asthma. Oral BDP may also have application in treating other GI disorders characterized by severe inflammation such as Crohn's disease and radiation enteritis.
The FDA has cleared the Investigational New Drug (IND) application for OrbeShield™ for the mitigation of morbidity and mortality associated with GI ARS. OrbeShield™ has also been granted Orphan Drug and Fast Track designations by the FDA for the prevention of death following a potentially lethal dose of total body irradiation during or after a radiation disaster.
About Soligenix, Inc.
Soligenix is a development stage biopharmaceutical company developing products to treat serious gastrointestinal diseases where there remains an unmet medical need, as well as developing several biodefense vaccines and therapeutics. Soligenix is developing proprietary formulations of oral BDP (beclomethasone 17,21-dipropionate) for the prevention/treatment of gastrointestinal disorders characterized by severe inflammation, including pediatric Crohn's disease (SGX203), acute radiation enteritis (SGX201) and chronic Graft-versus-Host disease (orBec®), as well as developing its novel innate defense regulator (IDR) technology SGX942 for the treatment of oral Mucositis.
Through its BioDefense Division, Soligenix is developing countermeasures pursuant to the Biomedical Advanced Research and Development Authority (BARDA) Strategic Plan of 2011-2016 for inclusion in the US government's Strategic National Stockpile. Soligenix's lead biodefense products in development are a recombinant subunit vaccine called RiVax™, which is designed to protect against the lethal effects of exposure to ricin toxin and VeloThrax™, a vaccine against anthrax exposure. RiVax™ has been shown to be well tolerated and immunogenic in two Phase 1 clinical trials in healthy volunteers. Both RiVax™ and VeloThrax™ are currently the subject of a $9.4 million National Institute of Allergy and Infectious Diseases (NIAID) grant supporting development of Soligenix's new vaccine heat stabilization technology known as ThermoVax™. Soligenix is also developing OrbeShield™ for the treatment of gastrointestinal acute radiation syndrome (GI ARS) under a $600,000 NIAID Small Business Innovation Research (SBIR) grant. OrbeShield™ has previously demonstrated statistically significant preclinical survival results in two separate canine GI ARS studies funded by the NIH.
For further information regarding Soligenix, Inc., please visit the Company's website at www.soligenix.com.
This press release contains forward-looking statements that reflect Soligenix, Inc.'s current expectations about its future results, performance, prospects and opportunities. Statements that are not historical facts, such as "anticipates," "believes," "intends," or similar expressions, are forward-looking statements. These statements are subject to a number of risks, uncertainties and other factors that could cause actual events or results in future periods to differ materially from what is expressed in, or implied by, these statements. Soligenix cannot assure you that it will be able to successfully develop or commercialize products based on its technology, particularly in light of the significant uncertainty inherent in developing vaccines against bioterror threats, manufacturing and conducting preclinical and clinical trials of vaccines, and obtaining regulatory approvals, that product development and commercialization efforts will not be reduced or discontinued due to difficulties or delays in clinical trials or due to lack of progress or positive results from research and development efforts, that it will be able to successfully obtain any further grants and awards, maintain its existing grants which are subject to performance, enter into any biodefense procurement contracts with the US Government or other countries, or that the US Congress may not pass any legislation that would provide additional funding for the Project BioShield program. These and other risk factors are described from time to time in filings with the Securities and Exchange Commission, including, but not limited to, Soligenix's reports on Forms 10-Q and 10-K. Unless required by law, Soligenix assumes no obligation to update or revise any forward-looking statements as a result of new information or future events.
SOURCE Soligenix, Inc.


text:
How to add a select (or other form element)?
In forms towards Eliom services:
open Eliom_content
Html5.D.string_select ~name:select_name
([] (* attributes *),
"Bob" (* value *),
None (* Content, if different from value *),
false (* not selected *))) (* first line *)
[Html5.D.Option ([], "Marc", None, false);
([], "Karin", None, false),
[([a_disabled `Disabled], "Juliette", None, false);
([], "Alice", None, true);
([], "Germaine", Some (pcdata "Bob's mother"), false)]))]
There is also int_select, float_select, etc. depending on the type expected by the service.
Basic HTML5 elements without Eliom services
For example if you want to use them with client side event handler.
open Eliom_content.Html5.D
Raw.select [option (pcdata "hello");
option ~a:[a_value "a"; a_selected `Selected] (pcdata "cool")]
- How to write forms
- Eliom forms and links
- API Eliom_content.Html5.D
- module Html5.M (HTML5 Elements)
- signature Html5_sigs.T (Element attributes)