text:
Departments and concentrations may request up to $600 to fund academic speakers. We encourage departments and concentrations to collaborate and pool funds if they wish to bring in speakers requiring greater funding. Funds should be used to cover all costs of speakers including travel, meals, lodging, and honoraria.
You will be notified by e-mail of approval/disapproval.
Thank You!
Revised November 2017


text:
Papa John's Pizza Prices and Locations in Mililani Town, HI
Papa John's Pizza - 94-780 Meheula Pkwy
Mililani Town, Hawaii (808) 627-7272
Looking for a Papa John's Pizza near you?
Headquartered in Jeffersontown, Kentucky, Papa John's Pizza is the third largest take-out and pizza delivery restaurant chain in the world. Papa John's began to have operations in 2001, and had had 300 shops in the Uk until 2015. Its menu primarily consists of pizzas, sides, desserts, drinks and others.
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subset: commoncrawl


text:
Wednesday, April 6, 2011
katezilla: a random update
So, the little monster continues to do well. Progress is slow of course, but she is moving forward; always a good thing.
Now this part is so far unconfirmed by me, but she's managed to say "Mama" for the first time ever. On multiple occasions. Never around me. With me, she just signs "Mama." The singing frog as usual. But, CT and PT have confirmed this, so I'll take them at their word. "Dada" has never been a problem. I'm the light of her life. ;)
Last week after returning home from school, I heard her string 2 words together, "up dada." I was in my office and she was downstairs with someone else. She said it like 30 times. I think she was telling "someone" where I was and that she wanted to come up and visit. Pretty cool.
Wow. I think that's it. Cool.
The red-headed step child
You might think my son, with the same name, is neglected. Not at all. He might get short shrift here, but not in real life.
He is a brilliant, good looking (his mom's side), polite and funny little dude. Speaking of funny, let me share a conversation we had with him the other night.
It's bedtime and he comes into my office.
LC: "Dad, can I get another little brother or sister?"
Me: "Why?"
LC: "I want to have someone to play with, or have someone else to play with Kate."
I'm thinking, that's pretty nice of him.
Me: "Well, we can't have another kid."
LC: "Why?"
Me: "It would kill your mom. Her body could barely deal with Kate's pregnancy, it might kill her."
Kris had gestational diabetes for both pregnancies, the 2nd, Kate, required insulin injections.
At this point, Kris has walked into the room.
LC: "Why don't you have a baby with another woman?"
Me: "Great question. Mom?"
Me: "I'm game if you are. :)"
After the ruckus died down, LC left to go to bed. Upon leaving he turned and said, "Now, I want to hear you two discussing this."
This conversation followed one from a month or 2 ago where he came home and asked, "What is sex?"
He's 8.
It's gonna be interesting.
4 comments:
- Bob Rhubart said...
Family: It's why we keep going, and why put up with the rest of the world.
Glad to hear everyone is doing well!
- April 6, 2011 at 3:43 PM
- Joel Garry said...
I know a married lady with kids, who's also in school, who became a surrogate to pay for grad school. She had triplets...
Recently Fox re-ran The Simpson's Lisa's first word episode, I assume because Liz Taylor said the word.
- April 6, 2011 at 7:15 PM
- Noons said...
Oh boy, LC is at that funny age!
Buddy, you're in for a really awesome ride as he develops!
- April 6, 2011 at 7:46 PM
- Gary Myers said...
My son is 8 but hasn't come out with those questions yet. There's a category of questions where I say "Let's check the internet". That certainly isn't one of them though.
As for adding to the family, make sure he's clear on the lead times for that sort of project. It's a lot easier just to borrow someone else's kids for a day or two. I'm talking sleepovers not kidnapping !
- April 8, 2011 at 5:08 PM


text:
Athletes try to remain positive, dry during wet sports season
PUNXSUTAWNEY — First-year PAHS girls' track and field coach Barry Young has a message for his athletes stuck on the bus or under shelter when the skies open up, as they have often this spring.
"There's nothing you can do about it, so try to keep a positive attitude," he said Thursday, one of the few days rain didn't fall.
When asked what the rain gauge in his backyard said Thursday night, Charles Hoeh, the borough's emergency management supervisor, replied, "Swim."
According to his reports, Monday saw 0.83 of an inch of rain, followed by 0.65 Tuesday; 0.34 Wednesday; and 0.35 Thursday. Last Sunday, the gauge measured only 0.03 of an inch.
When asked what his monthly records read, Hoeh, said, "It's easier to look at how many days it didn't rain."
Since the beginning of April up to Thursday, Hoeh's records said it rained 21 days during the whole month.
"We're way above average," he said. "I think I heard that we're 15 inches above average for the year."
Punxsy softball manager Alan Pifer said it's almost as if the coasts have moved.
"It's almost like you have the weather that Seattle and Vancouver get on a regular basis, and it has shifted over here," he said.
Between the PAHS baseball and softball teams, there have been about a dozen cancellations/postponements this season.
"It's frustrating," Pifer said. "You practice and practice, and you want to take what you have learned in practice and put it on the field. The rain just puts a damper on everything."
But in their own ways, athletes are dealing with the unusually wet spring.
"With track and field, that's the nature of the sport," Young said. "Some springs are good, and some are rainy like this year. When you live in this area, that's what you have to put up with."
Field events, such as pole vault and jumping events, are especially affected, because slippery surfaces simply make it too risky for athletes to practice. It can also extend to running events to a certain degree, Young said.
"It's the same for all teams in the area," he said. "In the local area, other district are going through the same situation as we are."
If it's anything that hurts athletes is their inability to get in quality practices due to inclement weather.
"It's hard to get personal bests when you're fighting the elements all the time," he said. "Where the weather is better, they're getting quality practices, and we are not getting quality practices."
He said he wants his girls to keep up their spirits, even if they're stuck on a bus being hit with raindrops.
"They're holding up pretty well," Young said. "I've been a track person all my life, and you have to deal with it. Stay as positive as you can. You might not get your best personal performance, but you do the best you can."
On the tennis court, PAHS boys' tennis coach Todd Heigley said his team has been pretty fortunate amid the rainy spring. A month into the 50-date, 12-match tennis season, he said the team has lost only seven days.
"Hollidaysburg had rain, but they have an indoor facility," he said. The team made it through about two-thirds of its match in St. Marys before rain forced the players to shelter.
That's not to say there haven't been some days the team has barely squeezed in its matches.
"The Clearfield match, there was green all around us on the radar, and we just split it up," Heigley said. "We were lucky to get it in."
The boys' tennis team has also been practicing in the gym, with "plenty of time to swing the racquets to get our shots working," he said.
As far as outdoor practice, Heigley said, "As long as the court is dry, we're fine."
A new tool Heigley has initiated this year is having the team practice Sunday evenings, "because it's seemed like the nicest day of the week." Since March 25, the team has picked times that work with their personal schedules and practice the night before the new school week begins. Plus, matches tend to be Mondays, Heigley said, so that players are ready the night before.
"I figured they're home and getting ready to get into swing for school for the next week," he said.
The challenge now, should the rain continue, is rescheduling matches that must he postponed. After a certain point in time, rescheduled matches start pushing into district matches, and eventually state matches.
"The state tournament takes precedence over districts," he said.
Baseball and softball have at least four games scheduled each week during the first three weeks of May to conclude the regular season.
"As long as we get them, I don't really care (about the postponements earlier in the year)," Pifer said.
Outside the realm of high school sports, Dan Pisarchick, club pro at the Punxsutawney Country Club, said the course has been open since "whenever the snow melted," and usage has been about average for this time of the year.
"A lot of guys have not come back from Florida until about now," he said, "but we're starting to see more people."
Despite wet weather and pooling of water on certain parts of the course, Pisarchick said, "The greens have been great, and the fairways are pretty wet. The players are making due. They understand they don't want to hurt their course. They want to make sure to take steps now to make it perfect for later."


text:
To: All Administrative Heads
From: President Gail Fullerton
Subject: 1983-84 Budget and "Freeze"
Chancellor Reynolds has lifted the formal "freeze" as of August 1, 1983. However, our budget has been cut deeply from the levels anticipated last spring when tentative allocations were made.
I am therefore directing that all appointments be approved by either the Executive Vice President or the Academic Vice President, as appropriate.
Further, any purchase of supplies or equipment in excess of $1000 must also be approved by the appropriate Vice President.
The Vice Presidents may delegate such authority to Associate Vice Presidents or Deans, but it is not to be delegated beyond this level of accountability at this time.
This Presidential directive replaces all earlier memoranda on the subject of the 1983-84 budget.
Budget Office,
Purchasing Officer,
Personnel Officer


text:
The Central Bank of Nigeria has inaugurated Bank Verification Number to revolutionise banking and payment systems in the country.
The BVN is a biometric authentication of bank customers using Point of Sale and Automated Teller Machines.
The biometric authentication is meant to address the safety of customers' funds and avoid losses through compromise of Personal Identification Numbers.
The CBN, at the launch in Lagos, said that banks would have captured biometric details of all customers nationwide within the next 18 months.
The platform already rolled out nationwide attracts no charges and it would allow banks to enroll and verify the identity of each customer from any point of transaction device.
All account holders with Banks in Nigeria are advised to ensure they are verified and biometrically registered as they may not be able to carry out transactions after the 18 months registration period.
Lagos Economic Summit (Ehingbeti 2014) holds on April 8 - 10, 2014 at the Eko Hotel and Suites, V/I, Lagos
Agribusiness Conference and Exhibition comes up on May 6-8, 2014 at the international Conference Centre, Abuja.
Wed Expo comes up on May 12 and 13 at the M and E events centre, opposite Nicon Luxury Hotel, Abuja
Home Exhibition (HOMEX) holds on April 29 - May 1, 2014 at the Eko Hotel Exhibition Centre, V/I, Lagos.
Cosmetics Exhibition (COSMEX) holds on April 29 - May 01, 2014 at the Eko Exhibition Centre, Eko Hotel, V/I, Lagos.
Agriculturl and Food Products Exhibition (AGFOPEX) holds on April 29 - May 01, 2014 at the Eko Exhibition Centre, Eko Hotel, V/I, Lagos.
Building Materials Exhibition (BUILDMACEX) holds from September 9 - 11, 2014 at the Eko Exhibition Centre, Eko Hotel, V/I, Lagos.
Yaw Live on Stage with Julius Agwu, et all on Sunday March 30, 2014 at the Eko Hotel and Suites, V/I, Lagos.
You can make a visit to the Nekede Zoo. This is located at the old Nekede in Owerri and is a complex, fully-equipped garden. Visitors can admire here different types of animals, from Ostrich, Lions and Monkeys to Pythons, Guerrillas and Crocodiles.
Owerri people are friendly, hospitable and always out to help visitors to the city and the natural beauty with mangrove trees, rainforests and scenic locations .
All hotels in the Owerri require visitors to pay on arrival before going to their room. However, it is advisable to pay in cash and avoid credit card usage as credit cards are not widely accepted. Owerri metropolis and the new business district of the city are among the best places to find an accommodation in the city.
Gashaka-Gumti National Park is located in the mountainous region of north-eastern Nigeria adjacent to the international border with Cameroon, and immediately to the north of Mambilla Plateau.
The Park experiences varying pleasant weather conditions, depending on one's location within the Park. These range from tropical dry humid, tropical moist humid in the lowlands to sub tropical highland weather on the high plateau around Chappal waddi, Sabere and Fillinga. Infact , the hidden corner of West Africa ,that is Gashaka-Gumti National Park, is surely one of Africa's best kept secret.
ANTROPOGENIC FEATURES: The Park also contains some historic sites one of which is the pre 1918 German fort and garrison top of Gashaka Hill once used as a " watch tower " by the German military expedition to that area. Graves of some fallen German soldiers could still be seen dotted around the Fort.
VEGETATION/ FAUNA SPECIES: The Park has five distinct ecological zones ranging from Scrub and Guinea Savanna to fringing lowland rainforest, montane forest . The graduation of these ecosystems are based on both the latitudinal and altitudinal gradients of the biogeography of the Park.
The fauna species inventory of this Park includes giant forest hog, leopard, yellow-backed duiker, golden cat , and eight of Nigeria's known 23 Primates including chimpanzees in the forest ecotone .The savannas are home to buffalo, lion, elephant and wild dog , water-buck, roan-antelope, giant-eland, kob and Hartesbeest. Up in the mountains one can encounter the mountain reedbuck, black and white colobus monkey, baboon, warthog, oribi and klipspringer.
SPORT FISHING: Gashaka-Gumti has ideal spots for sport-fishing, one of which is at Mayo Kam near the Hippo-pool. In the dry season the water is crystal clear and one can easily see different varieties ranging from Tiger, Cat fish, Nile perch, Tilapia fish gliding in the water.
MOUNTAINEERING: Gashaka Sector of the Park has rugged undulating mountain terrains, excellent for mountaineering and cave exploration. It contains the highest mountain summit in Nigeria the "Chappal Waddi", which literally means " the mountain of death" standing at an altitude of 2,400 meters' above sea level.
PRIMATE WATCHING Forests in Chappal Waddi, Chappal Hendu, Chappal Yumti, Chappal sirgu and Kwano forest are good primate strongholds. One is sure to sight chimpanzees here or at least hear their calls or see their nests.
WILDERNESS TREKKING: Gashaka-Gumti National Park , wild and scenic areas are accessible only by footpath and only by trekking can one savor the tranquility through the forest canopy ,rare fauna, crystal clear forest streams, waterfalls and picturesque mountain views.
ACCESS TO THE PARK: Gashaka sector of the park can be accessed through Katsina Ala-Takum-Bali-Serti –Bodel Gate and the other from Jalingo- Mutum Biyu-Bali-Serti-Bodel Gate, while the main access to Gumti sector is from Yola-Mayo Belwa-Ganye-Sugu-Toungo. The closest airport is at Yola. However, there is an airstrip for light aircraft in Serti, which could be used by visitors.
ACCOMMODATION: At present the Park has limited furnished accommodation facilities in Serti town, Gashaka Base Camp and Toungo. Good Camping sites also exit within and around the park; Mayo-kam, Mayo-gashaka, Mayo-gamgam and Yakuba for outdoors camping.
The new Freedom Park is located on the site of the colonial prison where prominent Nigerians had their jail terms during the colonial era. The park, which is now a peaceful place for individual and collective contemplation and interaction is open to public daily.
Located in Lagos Island, Lagos, the park is a brainchild of a Lagos-born architect and visionary, Theo Lawson, who had a vision to transform the colonial prison to a symbol of freedom.
This prison was used by the British colonial masters to torture, imprison and hang in the gallows those that opposed colonial rule of Nigeria including Herbert Macaulay, Chief Cbafemi Awolowo, Chief Michael Imodu, Sir Adeyemo Alakija and others.
Freedom Park is a memorial leisure park dedicated to the preserving the Lagos colonial heritage and history of the Old Board Street prison. Today, freedom park provides venues for events and recreational entertainment.


text:
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Tuesday , July 10, 2018 - 2:24 PM
MATT HERP/Standard-Examiner
Ogden Raptors' Jacob Amaya (13) collides with Missoula Osprey's Brandon Leyton (12) on his way to third base Tuesday, July 10, 2018, at Lindquist Field in Ogden. Amaya was safe on the play.
OGDEN — Tuesday night was a sweltering summer night at Lindquist Field, the kind that kept some fans away in favor of air conditioning.
The heat — it was 97 degrees with no wind at first pitch — came on the same night the Ogden Raptors' lineup reignited after a brief, two-game dormancy, scoring 11 runs on 12 hits in an 11-4 win against the Missoula Osprey (13-12).
The two clubs combined for 21 base hits and 10 errors, a very rookie league-esque statistic. One thing non-rookie league about Tuesday's game was Ogden (16-9) pitchers issuing just one walk.
Because of the errors (perhaps a product of Monday being the first off day all season in the Pioneer League), every pitcher's ERA was relatively spared.
Ogden first baseman Dillon Paulson broke the game open with a three-run home run to left field to extend the Raptors' lead to 4-0 in the third inning.
Paulson also made a nice catch in the fourth inning to spear a line drive that came when the batter's box was in the shade and first base was in the sun.
The Raptors hung six runs on Missoula in the third inning as James Outman and Jair Camargo drove in two runs after Paulson's homer. Technically, those six runs were more than enough for the Raptors.
But for good measure, Camargo launched a two-run homer in the fifth inning to put the Raptors up 8-2. Ronny Brito's RBI single made it 9-2 in the sixth and Miguel Vargas' easy RBI double in the eighth made it 10-4 before Brito brought in another run.
Every Ogden batter contributed either a base hit or an RBI. Joel Inoa struck out five batters through the first 4 2/3 innings in the win and the bullpen, particularly Austin Drury, made quick work of the Osprey in the later innings.
Gersel Pitre's fourth stint in Ogden is over after he was called back to up Single-A Great Lakes on Monday. Pitre went 6 for 12 at the plate with five RBIs in three games after being assigned him to Ogden earlier this season.
Pitcher Stephen Kolek was also promoted to Great Lakes. He threw 4 1/3 innings in three appearances for Ogden, allowing three earned runs.
Missoula's Buddy Kennedy smacked a solo home run in the fifth inning that hit the protective netting two-thirds of the way up the scoreboard in left field.
Had there not been any netting, the home run ball likely would've hit the part of the scoreboard where his name was displayed as the current batter.
You can reach prep sports reporter Patrick Carr at firstname.lastname@example.com. Follow him on Twitter at @patrickcarr_ or like him on Facebook at Facebook.com/patrickcarr17.


text:
The NNTP forums from Sybase - forums.sybase.com - are now closed.
All new questions should be directed to the appropriate forum at the SAP Community Network (SCN).
Individual products have links to the respective forums on SCN, or you can go to SCN and search for your product in the search box (upper right corner) to find your specific developer center.
General Discussionsybase.public.powerdesigner.general
9856 questions and
20893 responses
(30749 total posts)
Last article posted on 2013-03-20 13:39:01.0Z 2013-03-20 13:39:01.0 30749


text:
Stem-loop sequence rno-let-7e
|MI0000832 (change log)
|Rattus norvegicus let-7e stem-loop
|Gene family
|MIPF0000002; let-7
|Community annotation
This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...
The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.
The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans,[1] and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs.[2] miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.
Genomic Locations
In human genome, the cluster let-7a-1/let-7f-1/let-7d is inside the region B at 9q22.3, with the defining marker D9S280-D9S1809. One minimal LOH (loss of heterozygosity) region, between loci D11S1345-D11S1316, contains the cluster miR-125b1/let-7a-2/miR-100. The cluster miR-99a/let-7c/miR-125b-2 is in a 21p11.1 region of HD (homozygous deletions). The cluster let-7g/miR-135-1 is in region 3 at 3p21.1-p21.2.[3]
The let-7 family
The lethal-7 (let-7) gene was first discovered in the nematode as a key developmental regulator and became one of the first two known microRNAs (the other one is lin-4).[4] Soon, let-7 was found in fruit fly, and identified as the first known human miRNA by a BLAST (basic local alignment search tool) research.[5] The mature form of let-7 family members is highly conserved across species.
In C.elegans
In C.elegans, the let-7 family consists of genes encoding nine miRNAs sharing the same seed sequence.[6] Among them, let-7, mir-84, mir-48 and mir-241 are involved in C.elegans heterochronic pathway, sequentially controlling developmental timing of larva transitions.[7] Most animals with loss-of-function let-7 mutation burst through their vulvas and die, and therefore the mutant is lethal (let).[4] The mutants of other let-7 family members have a radio-resistant phenotype in vulval cells, which may be related to their ability to repress RAS.[8]
In Drosophila
There is only one single let-7 gene in the Drosophila genome, which has the identical mature sequence to the one in C.elegans.[9] The role of let-7 has been demonstrated in regulating the timing of neuromuscular junction formation in the abdomen and cell-cycle in the wing.[10] Furthermore, the expression of pri-, pre- and mature let-7 have the same rhythmic pattern with the hormone pulse before each cuticular molt in Drosophila.[11]
In vertebrates
The let-7 family has a lot more members in vertebrates than in C.elegans and Drosophila.[9] And the sequences, expression timing, as well as genomic clustering of these miRNAs members are all conserved across species.[12] The direct role of let-7 family in vertebrate development has not been clearly shown as in less complex organisms, yet the expression pattern of let-7 family is indeed temporal during developmental processes.[13] Given that the expression levels of let-7 members are significantly low in human cancers and cancer stem cells,[14] the major function of let-7 genes may be to promote terminal differentiation in development and tumor suppression.
Regulation of expression
Although the levels of mature let-7 members are undetectable in undifferentiated cells, the primary transcripts and the hairpin precursors of let-7 are present in these cells.[15] It indicates that the mature let-7 miRNAs may be regulated in a post-transcriptional manner.
By pluripotency promoting factor LIN28
As one of the four genes involved in induced pluripotent stem (iPS) cells reprogramming,[16] LIN28 expression is reciprocal to that of mature let-7.[17] LIN28 selectively binds the primary and precursor forms of let-7, and inhibits the processing of pri-let-7 to form the hairpin precursor.[18] This binding is facilitated by the conserved loop sequence of primary let-7 family members and RNA-binding domains of LIN28 proteins.[19] On the other hand, let-7 miRNAs in mammals have been shown to regulate LIN28,[20] which implies that let-7 might enhance its own level by repressing LIN28, its negative regulator.
In autoregulatory loop with MYC
Expression of let-7 members is controlled by MYC binding to their promoters. The levels of let-7 have been reported to decrease in models of MYC-mediated tumorigenesis, and to increase when MYC is inhibited by chemicals.[21] In a twist, there are let-7-binding sites in MYC 3' untranslated region(UTR) according to bioinformatic analysis, and let-7 overexpression in cell culture decreased MYC mRNA levels.[22] Therefore, there is a double-negative feedback loop between MYC and let-7. Furthermore, let-7 could lead to IMP1(/insulin-like growth factor II mRNA-binding protein) depletion, which destabilizes MYC mRNA, thus forming an indirect regulatory pathway.[23]
Targets of let-7
Oncogenes: RAS, HMGA2
Let-7 has been demonstrated to be a direct regulator of RAS expression in human cells[24] All the three RAS genes in human, K-, N-, and H-, have the predicted let-7 binding sequences in their 3'UTRs. In lung cancer patient samples, expression of RAS and let-7 showed reciprocal pattern, which has low let-7 and high RAS in cancerous cells, and high let-7 and low RAS in normal cells. Another oncogene, high mobility group A2 (HMGA2), has also been identified as a target of let-7. Let-7 directly inhibits HMGA2 by binding to its 3'UTR.[25] Removal of let-7 binding site by 3'UTR deletion cause overexpression of HMGA2 and formation of tumor.
Cell cycle, proliferation, and apoptosis regulators
Microarray analyses revealed many genes regulating cell cycle and cell proliferation that are responsive to alteration of let-7 levels, including cyclin A2, CDC34, Aurora A and B kinases (STK6 and STK12), E2F5, and CDK8, among others.[26] Subsequent experiments confirmed the direct effects of some of these genes, such as CDC25A and CDK6.[27] Let-7 also inhibits several components of DNA replication machinery, transcription factors, even some tumor suppressor genes and checkpoint regulators.[26] Apoptosis is regulated by let-7 as well, through Casp3, Bcl2, Map3k1 and Cdk5 modulation.[28]
Let-7 has been implicated in post-transcriptional control of innate immune responses to pathogenic agents. Macrophages stimulated with live bacteria or purified microbial components down-regulate the expression of several members of the let-7 microRNA family to relieve repression of immune-modulatory cytokines IL-6 and IL-10.[29][30] Let-7 has also been implicated in the negative regulation of TLR4, the major immune receptor of microbial lipopolysaccharide and down-regulation of let-7 both upon microbial and protozoan infection might elevate TLR4 signalling and expression.[31][32] Let-7 has furthermore been reported to regulate the production of cytokine IL-13 by T lymphocytes during allergic airway inflammation thus linking this microRNA to adaptive immunity as well.[33] Down-modulation of let-7 negative regulator Lin28b in human T lymphocytes is believed to accrue during early neonate development to reprogramm the immune system towards defense.[34]
Potential clinical use in cancer
Given the prominent phenotype of cell overproliferation and undifferentiation by let-7 loss-of-function in nematodes, and the role of its targets on cell destiny determination, let-7 is closely associated with human cancer and acts as a tumor suppressor.
Numerous reports have shown that the expression levels of let-7 are frequently low and the chromosomal clusters of let-7 are often deleted in many cancers.[3] Let-7 is expressed at higher levels in more differentiated tumors, which also have lower levels of activated oncogenes such as RAS and HMGA2. Therefore, expression levels of let-7 could be prognostic markers in several cancers associated with differentiation stages.[35] In lung cancer, for example, reduced expression of let-7 is significantly correlated with reduced postoperative survival.[36]
Let-7 is also a very attractive potential therapeutic that can prevent tumorigenesis and angiogenesis, typically in cancers that underexpress let-7.[37] Lung cancer, for instance, has several key oncogenic mutations including p53, RAS and MYC, some of which may directly correlate with the reduced expression of let-7, and may be repressed by introduction of let-7.[36] Intranasal administration of let-7 has already be found effective in reducing tumor growth in a transgenic mouse model of lung cancer.[38] Similar restoration of let-7 was also shown to inhibit cell proliferation in breast, colon and hepatic cancers, lymphoma, and uterine leiomyoma.[39]
Further reading
External links
c cc c cu g u ggaaga ac 5' gcgc cc ggg gag uaggagguuguauagu ga c c |||| || ||| ||| |||||||||||||||| || | 3' cgcg gg ccc uuc auccuccggcauauca cu g c c uc a cu g - --agag ag
|Deep sequencing
Annotation confidence: high
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The ends of the miRNA may be offset with respect to previous annotations.
|Genome context
|Clustered miRNAs
|Database links
Mature sequence rno-let-7e-5p
|Previous IDs
15 -
- 36
|Deep sequencing
|705698 reads, 39 experiments
|experimental; cloned [1-3], SOLiD [4]
|Predicted targets
Mature sequence rno-let-7e-3p
|Previous IDs
60 -
- 81
|Deep sequencing
|954 reads, 33 experiments
|experimental; cloned [3], SOLiD [4]
|Predicted targets
PMID:14691248 "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons" Proc Natl Acad Sci U S A. 101:360-365(2004).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Cell. 129:1401-1414(2007).
PMID:20403161 "Small RNA expression and strain specificity in the rat" BMC Genomics. 11:249(2010).


text:
Search our database of handpicked sites
Looking for a great physics site? We've tracked down the very best and checked them for accuracy. Just fill out the fields below and we'll do the rest.
You searched for "Bohr model of the atom", type: Website
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What is the structure of an atom?
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One-dimensional one-atom gas
This is a very simple model of a gas. Here, a single atom bounces elastically in a one-dimensional cavity. It will continue to bounce at the same speed forever if the piston does not move.
Photon Absorption
Explanation of the absorption of photons in an hydrogen atom and its energy levels. Use of the Bohr and Rydberg equations.
Hyperphysics - The Nucleus
Relative scale models of an atom, descriptions of size and density of the nucleus and the strong force, with good links to other sites
Simple Flying Machines Theme Page
Information about model hot air balloons, kites and paper airplanes. Includes teacher demonstrations, experiments and instructions for making models.
The Phantom's Portrait Parlor (the Atoms Family)
Well presented site which considers Phases of Matter, Spectroscope of an Atom, Paper Cutting and Mighty Molecules.
All about atoms
Basic information about atoms and their structure, attractively presented and including some 'fun facts' about atoms.
Hydrogen Spectrum
The basic hydrogen energy level structure is in agreement with the Bohr model. Common pictures are those of a shell structure with each main shell associated with a value of the principal quantum ...
Liftoff! Models Rockets for Schools
Resources, information, and ideas about model rockets for schools
Aage Niels Bohr
Aage Niels Bohr (1911 - ) received the Nobel Prize for Physics in 1975 along with Ben Roy Mottelson and Leo James Rainwater.
The Atoms Family
With the Atoms Family learn about electricity, light, matter, waves, atoms, energy with fun activities and animations.


text:
What to do here? I have uninstalled old version and have tried multiple times on multiple downloads this same error. I have gone ove rall the troubleshooting docs and changed security settings and still same error. Thoughts?
32 bit Microsoft 7 Explorer
Download and run the offline installer from http://helpx.adobe.com/flash-player/kb/installation-problems-flash-player-windows.html#Ins tall_in_a_firewall_proxy_server_environment


text:
Adams State becomes a University
A crowd of over 300 gathered under calm blue skies to witness Colorado Governor John Hickenlooper sign the law designating Adams State University, May 19. A banner proclaiming "Our great story just got better" set the stage for the 91-year-old institution's move to university status.
"You talk about oil, you talk about wind energy . . . the energy of our youth is the most powerful energy we have in this country, and you guys are helping make sure we get the most out of it," Hickenlooper said. "In all of Colorado, it's hard to find another community with as strong a sense of place as what you have created here. A good university is the heart of great community."
Adams State President David Svaldi welcomed the audience by recalling the school's founder and early presidents: "Somewhere, Governor Billy Adams is smiling and perhaps toasting this wonderful event with President Richardson and President Plachy. "Governor Adams worked his entire political career to found a teacher preparation school (so-called normal school) in the San Luis Valley. Against all odds, including political opponents and the Ku Klux Klan, Adams worked successfully with his constituents to legislate funds to construct the Normal School."
There is an "unbreakable bond of community" between Adams State and the San Luis Valley, Svaldi added, telling how - when Adams' opponents blocked state funding - area residents donated produce, livestock, and other products to raise the school's first operating budget of $25,000.
"Now we are here today to celebrate the next chapter in the great story of Adams State. I again have to thank our community for helping us to this juncture. Now our name will reflect what we truly are: Adams State University," he said.
Alamosa Mayor Kathy Rogers presented a proclamation declaring August, 2012, as the Month of Adams State University. "We are so fortunate and pleased to have Dr. Svaldi with us. He has done so much for this campus and our city."
The name change was proposed in HB 1080, co-sponsored by House Representative Ed Vigil State and Senator Gail Schwartz.
"Today is a day of pride and honor," said Vigil, a 1986 graduate of Adams State. "I'm so proud of our college that is now a university; it was an honor for me to run the bill."
Schwartz also said, "It was a privilege to sponsor this bill, and to know what a difference it will make, both for today's students and those to come in the future."
The name change will be official Aug. 7, 2012. The college's Board of Trustees voted to pursue the change Aug. 26, 2011, after exploring the issue for three years. Founded in 1921, Adams State Normal School was created to educate teachers for rural Colorado.
When it opened in 1925, the campus had one building, three faculty, and 42 students. Adams State now boasts a campus of 54 buildings and recently completed $62 million in campus construction and renovation. The university employs 110 full-time faculty and 358 staff. Enrollment has increased by 34 percent since 2008.
Adams State University has enjoyed record-breaking enrollment for the last three years, with a total of 3,701 students as of the fall 2011 semester. One quarter of those students are enrolled in one of the university's nine graduate programs.
In 2001, Adams State became Colorado's first four-year institution to be federally designated a Hispanic Serving Institution (HSI). Since then it has received more than $14.1 million in Title V and other grants to help HSI's improve capacity and services. The undergraduate student body is 33 percent Hispanic; an additional 14 percent of students identify as members of other ethnic/racial minority groups.
In 1929, the institution's name shifted to Adams State Teachers College of Southern Colorado, in 1938 to Adams State Teachers College, and then Adams State College, adopted in 1946, in recognition of the broader offering of under-graduate liberal arts programs and the expansion of graduate degree programs.
Watch video of bill signing ceremony
By Julie Waechter


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Join Date: Jan 2013
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Re: MCU Phase 3: Have it your way
Well an elaboration for mines would be
2015: Ant-Man- Introduces Hank and Janet. We see Hank working on Ultron. Villain would be A.I.M. End of the movie introduces Scott Lang but only as the janitor for now.
2016: Thor 3 - Not well versed in Thor lore
2016: Dr. Strange - Origin story Strange is a hot shot doctor who gets into an accident that destroys his life. Not knowing what to do now Strange goes on a journey to get his life back and finds his true destiny along the way. Introduces the magic realms of the MCI.
2017: Cap 3: Rise of Namor - As the world fills with more super powered beings a threat lurks beneath the sea. An Alantean that is on the surface world is killed between the struggle between a hero and villain. Namor having had enough decides to come to the surface world and deal with the problem. End credits scene we see Fury sitting with Cap reading a newspaper. Cap shows him a section of the paper and Fury shakes his head saying he wishes for the days when a drunken Tony Stark was his biggest problem then it cuts to an ad in the magazine for Heroes For Hire.
2017: Heroes for Hire - Luke Cage and Iron Fist origin stories through flashbacks. The origins of their team up are explored. The plot revolves around them helping Ant-Man retrieve his stolen suit. By the end of it Scott Lang is reintroduced and Ant-Man is seen letting him keep the suit. Setting up Avengers 3.
2017: Black Panther - Set in a mix of Wakanda and New York. Origins of Black Panther are explored in depth. Explains Wakanda and it's lore. BP faces Ape-Man. In the mix BP goes to New York and breaks into Tony Starks lab and plants a virus in his system. He then makes himself known so Iron Man can come after him in Wakanda. There they fight and BP activates the virus rendering Tony's suit useless. Having defeated Iron Man he offers BP a shot on the team after realizing BP is not a villain. Lead in to Avengers.
2018: Avengers 3: Wrath of Ultron - We see Hank has completed Ultron and has created a new costume and is now going by Giant Man. On a test run Hank sees a child killed by a villain and is devasted venting to Ultron that humanity is flawed and wishes he could fix it. Ultron then began downloading all the information in the world and comes to the conclusion that in order for humanity to be saved it must first be destroyed and cleansed. Meanwhile the Avengers are introduced to their newest member Black Panther who everyone is initially weary of but after seeing him in action loosen up. Add in many other details Avengers fight Ultron and win.
I wanna add Ms Marvel in there but can't see to figure out where.
1) Man of Steel 2) Thor 2 3) The Wolverine 4) Pacific Rim 5) Iron Man 3 6) Oblivion 7) Mortal Instruments: City of Bones 8) Ender's Game 9) Beautiful Creatures 10) After Earth
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HARTSVILLE, S.C. – Coker College cross country coach Vic Finora announced today that Taylor Hall has signed a national letter of intent to run for the Cobras beginning in the 2013-14 academic year.
"I am very excited that Taylor will be a Cobra next year," said Finora. Throughout her career, Taylor has proven to be a fierce competitor on the course and a dedicated student in the classroom. She brings immediate experience and leadership to what will be a relatively young squad. I believe Taylor still hasn't reached her potential, and I will lean on her early to instill a strong work ethic and winning attitude within our program."
Hall is transferring to Coker from Darton College in Georgia, where she was a two-sport athlete in cross country and women's basketball as well as an academic All-American. At Darton she was part of two conference championships, two regional championships and two appearances in the National Junior College Athletic Association Division I Cross Country Nationals.
Hall is originally from Effingham County High School in Springfield, Ga. She was a four-sport athlete for the Rebels in cross country, basketball, soccer and softball.
Taylor is the daughter of Thomas Hall and Blaine and Catina Deal.
For more information, contact Chris Dougherty, manager of athletics media relations and marketing, at 843-383-8018 or email@example.com.
Coker College readies undergraduates for personal and professional success through a distinctive four-year program that emphasizes a practical application of the liberal arts as well as hands-on and discussion-based learning within and beyond the classroom. Coker is ranked among the "Best Colleges" in the South by U.S. News & World Report as well as The Princeton Review. Located in Hartsville, S.C., Coker is within two hours of the cultural, financial and recreational resources of Charlotte, Columbia, Charleston and Myrtle Beach.


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Combat back pain July 25
Low back pain is one of the most common physical ailments in our society. It interrupts our lives, interferes with our ability to work, disrupts our sleep and costs Americans billions of dollars each year.
As with most illnesses and ailments, prevention is the key to living a healthful and pain-free life. Greg Frounfelter, Ripon Medical Center staff physical therapist, will present Oh, My Aching Back! at 6:30 p.m. Wednesday, July 25, at the Fond du Lac Public Library. He'll provide simple tips that can help minimize the risk for back injury and help maintain a healthy spine throughout a lifetime.
The presentation is free; no registration required.


text:
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Vince Stead
Vince Stead was born in Pontiac Michigan, and had 4 older brothers and 2 older sisters. Vince's mother passed away from cancer at the age of 37, and Vince was 18 months old at the time. Vince spent a little bit of time with other relatives, then was reunited with his father, who was a life long alcoholic, but was a nice father.
Vince's father owned a string of bakeries, but there was never really any money, his father drank and spent it away most of the time. At a very early age, Vince would go with his father every day to work, where is father and helpers would make all the bakery products at one bakery, and deliver them to the other bakeries every morning, and Vince would ride in the delivery van with his father every day until he was old enough to go to school. Vince learned at an early age, that is father required him to pay for his stuff, like new school clothing and other stuff. Through out Vince's whole childhood life, he worked weekends with his father in the middle of the night at his bakery, to earn money to buy clothes for school.
Vince got his first real job as a paperboy at the age of 11, and kept that job instead his was 13, when he got a better job washing dishes at the local Harvey's Country Kettle Restaurant, where he would ride his bike to and from the restaurant several nights a week after school. Vince kept the dish washing job until he was 15 years old, and got a job a big grocery store in the next town over. Vince did not have a drivers license yet, but he really wanted to keep his job, so he would hitch hike after school to his grocery store job, and sometimes he would be picked up by his teacher, and she would give him a ride to work.
All of Vince's brother's and sisters we required to move out of the house before they turned 16 years old. Vince was able to talk his older friend into renting an apartment with him, that worked at the grocery store also. The manager was nice enough at the grocery store to let Vince work nights shining the grocery store isles with a machine, and working each Sunday, where the other employees were only allowed to work every other Sunday, because the grocery store paid over time, and Ron the manager, had a kind heart.
Vince joined the Navy when he was 18 and liked it very much. He spent 4 years on shore duty at an air squadron, and 4 years at sea duty, where he was stationed on a submarine tender, the USS Proteus, and a destroyer, the USS David R. Ray, and a short stint on the USS Nimitz aircraft carrier. While on the destroyer, the ship would escort Kuwaiti oil tankers full of oil destined for America, out to sea so they would not get attacked. They would put an American flag on their ship, and the destroyer Vince was stationed on would escort them out to sea and safety so everyone back in America could get cheap oil at the time
While Vince was in the Navy and living in San Diego, California, he has always owned, raised, trained, and enjoyed dogs in his life.


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5th Grade Math Games
Don't get dizzy from math practice! Try these fun and interactive games to help your child review basic math concepts for fifth grade.Download All (8)
Download All is only available to Education.com Pro members. Learn More
Click on an activity in the set below to see more info.
Tic Tac Toe for Three Equations in a Row!View Full Activity
One way to "trick" your child into getting extra practice with one-step equations is to play a variation of the classic game, tic tac toe.
The Amazing Equation RaceView Full Activity
Here's an interactive, fast-paced game that will make your fifth grader feel more comfortable with simple equations.
Snag a Spoon! A Math GameView Full Activity
In this version of the classic card game, students will gain an understanding of equivalents and may not even realize it's a math review!
Card Pick UpView Full Activity
Improve critical thinking and logic skills as you compete to win in this fun, educational card game.
Be a Prime Number HunterView Full Activity
Wondering how to help your child get a handle on prime numbers? Turn her into a prime number hunter with this hundreds chart activity.
Probability Dice GameView Full Activity
Check out this dice game perfect for teaching your savvy kid the fundamentals of probability.
The set is continued below.
Simplify It!: A Fraction Card GameView Full Activity
Simplify fractions with your child in this fast-paced math card game.
Percent FlashView Full Activity
Challenge your kid to use his knowledge about percentages in this fun game. Just roll the dice and race to calculate the percentage.
Want to download this whole set as a single PDF?Download All (8)
Download All is only available to Education.com Pro members. Learn More


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New CygoLite Hotshot Pro 150 USB Rechargeable Li-Ion LED Bicycle Tail Light.
Product Overview:
If maximum visibility is important to you when riding in either full daylight or in the darkest of nights, this tail light will do the job. With 150 max lumens in the flashing mode, it may be used in full daylight to alert anyone behind you that a cyclist is ahead. With 6-modes and adjustable flash tempo and brightness the lighting affect can be quickly adjusted to best suite the current riding conditions and one's personal preference.
Our bicycle shop in Mount Horeb, Wisconsin, Trail This, is an authorized dealer for CygoLite lights. Full manufacturer warranty is included.
Additional International Info:


text:
The Nobel Prize in Physics 1978 was divided, one half awarded to Pyotr Leonidovich Kapitsa "for his basic inventions and discoveries in the area of low-temperature physics", the other half jointly to Arno Allan Penzias and Robert Woodrow Wilson "for their discovery of cosmic microwave background radiation".
Your mission is to arrange an amazing laser party!
Read more about the Nobel Prize in Physics.
All you want to know about the Nobel Prize in Physics!


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Queen Najla Parish - Family Drum Circle
Hosted by: Grove City Library
The event will start on: Jul 28, 2014 10:30 AM
And will end on: Jul 28, 2014 11:30 AM
Location: Grove City Library
Address: 3959 Broadway Grove City, OH 43123
Queen Najla Parrish - Family Drum Circle
Box drums, conga and other percussion instruments will be used to play creative music. Participation is encouraged! All ages.
Grove City Library
Monday, July 28 at 10:30 a.m.


text:
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Check out reviews left by other students or leave your own review. You could win a free scholarship.Add your Review
I love my school in Lafayette
Reviewer is A current student here.
1 of 4
Categories Comments Bang for the buck
You will definitely graduate as an educated member of society and become very competent to begin your career.
What to do for fun
Many attractions in Indiana
Food and Dining
Dining is ok
Dorm Life
Unsure as for I do not live in a dorm
Tips for prospective students
Keep in contact with all professors and be excited to learn.
In three sentences
I love this school and have nothing but good things to say about it. The Professors and staff are available to meet the needs of students, and the overall curriculum is set up to maximize achievement.
Jen from Lockport, IL
Reviewer is A current student here.
1 out of 1 people found this review useful. 2 of 4
Categories Comments Clubs and Activities
I suggest working for the hospital while going to school. It will help in the long run.
Bang for the buck
The cost of this school is cheaper than most schools are researched. I will be attending the accelerated program will graduate in 21 months.
What to do for fun
Lafayette is a small town there is a movie theater, mall, and Purdue University is about 10 minutes away.
Food and Dining
I will be living off campus
Dorm Life
I will be living off campus
Academic Rigor
I currently love the program. You start clinicals your first semester and by you second nursing class you are able to give injections.
Tips for prospective students
Admission is first come first serve. I suggest you apply early and have as many pre-reqs out of the way before you apply.
In three sentences
The cost of this school is cheaper than most schools are researched. I enjoy that the school class size is small and it is a diploma program.
Ashley from Lafayette, IN
Reviewer is A current student here.
3 of 4
Categories Comments Share any unusual traditions or locations on campus
On Fridays, I like to go out with a few of my current nursing students after class. Every week we pick somewhere new to go eat and we rotate on who pays for lunch that day. It is a lot of fun and while we are there, will we study while we are waiting for our food to get there. Once our food is there, we will talk about other topics.
Bang for the buck
The staff at the school is very helpful and they will respond to all questions rather quickly. When you go inside, everyone knows you. I feel like everyone is a family and I feel like an individual rather than just a number or a pay check.
What to do for fun
I like to go to the mall, or take my son to the park so he can play.
Food and Dining
Eating on campus is a copmpletely different experience. Everyone is very nice and they are willing to answer yorur questions when you are unsure of how everything works in and around campus.
Dorm Life
I do not live in the dorms so I do not know anything about dorm living.
Academic Rigor
A great school to attend if you are interested in becoming a nurse. They really work with you to get you where you want to go in life.
Tips for prospective students
Make sure you do all of your reading when it is due. Do not get behind with anything because by the end of the semester, you will get a lot of information thrown at you. If you do not understand something, make sure you ask right then and there.
In three sentences
Saint Elizabeth is a very good school to attend. You are able to learn a lot and get a lot of hands on experience. I am very happy with my choice of attending St E.
Cameron from Lafayette, IN
Reviewer is Accepted here and planning to attend soon. Reviewer has been to campus.
4 of 4
Categories Comments Great for these types of students
Great for students wanting the best education in Nursing.
What to do for fun
Meet knew people with the same goals, study together and have fun on the way.
Food and Dining
I do not know, I will not be eating or dining there.
Dorm Life
I do not know, I live off campus.
Tips for prospective students
Never give up or think it is too hard to graduate. Keep trying.
In three sentences
This school values their students' education. This school takes pride in their teachings. Saint Elizabeth School of Nursing tries hard to help every student succeed.


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This page contains a list of blogs and forums dedicatied to obesity related issues. More general blogs and forum may contain obesity related articles; go to the Health Well's Blogs and forums page to see the full list of these.
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DoH publishes its 10-year Sláintecare Implementation StrategySláintecare is the Irish government's reformation of Ireland's health and social care system. The strategy proposes a fundamental shift, vision and strategic plan for the future direction of the Irish health and social care services.The Implementation Strategy, launched late last week, sets out a ten year plan for reform with wide ranging recommendations covering five key areas:
You can download the implementation strategy here
For more information, click here
Minister for Health marks World Cancer Day
Ireland's survival rates for cancer patients have improved significantly – latest figures published by The Lancet
Public Health Alcohol Bill to return to the Oireachtas this week
The Minister for Health, Simon Harris has stressed the importance of taking steps, as a society, to prevent cancer. The Minister was marking World Cancer Day, which takes place every year on the 4th of February.
Minister Harris said "Ireland is making significant strides in cancer control. The latest figures published by The Lancet confirm we are moving up the global rankings and cancer survival rates here have improved significantly. Five-year survival rates for cancer have improved from 44.2% (1994-1998) to 61.1% (2010-2014).
"The National Cancer Strategy 2017-2026 aims to ensure that survival rates in Ireland continue to improve and that, over the lifetime of this Strategy, Irish survival rates will reach the top quartile in Europe. In achieving this we must also ensure that our services meet the needs of those living with and beyond cancer, from diagnosis and treatment to psycho-social support post-treatment. I am delighted to see a focus on improving the quality of life for cancer survivors through World Cancer Day"
Cancer in Ireland 1994 - 2015 with estimates for 2015 - 2017: Annual Report of the National Cancer Registry
The National Cancer Registry of Ireland has released its 22nd annual statistical report. This report summarises cancer incidence, mortality and survival in Ireland for the period 1994-2015, and provides projected estimates for incidence for the most recent three-year period: 2015-2017. The cumulative lifetime risk (to age 75 years) of an invasive cancer diagnosis was approximately 1 in 3 for men and 1 in 4 for women. The absolute risk difference between the most and least deprived 20% of the population was highest for pancreatic (+14%), lung (+9%), colon (+8%), oesophageal (+8%), and ovarian cancers (+7%). Age-standardized rates of all invasive cancers (excluding non-melanoma skin cancer (NMSC)) were 26% higher in men than in women. Overall, taking the first recorded invasive cancer (exc. NMSC) for each patient, the proportion of cases presenting as an emergency was 15% (of all cases whose admission type was known). The cancers with the highest proportion of emergency presentation were: pancreas (34%), lung (26%), ovary (24%) and colon (22%). For all cancer types, patients resident in the most deprived areas were more likely to present as an emergency. For all cancers examined, relative differences by deprivation were substantial, with patients from the most deprived group 25%-67% more likely to present as emergencies, depending on the cancer type (54% for all cancers combined). Similar data on cancer in Northern Ireland is available here.
Eating 10 portions of fruit and vegetables a day may give us longer lives, say researchers
The study, by Imperial College London, showed that while eating the recommended five a day still helps reduce the risk of disease, the highest benefits are seen in people who consume 10 portions and calculated such eating habits could prevent 7.8 million premature deaths each year. A portion counts as 80g (3oz) of fruit or veg - the equivalent of a small banana, a pear or three heaped tablespoons of spinach or peas. The team also identified specific fruit and veg that reduced the risk of cancer and heart disease. Lower risks of cancer were linked to eating; green veg (eg spinach); yellow veg (eg peppers), and cruciferous vegetables (eg cauliflower). Lower risks of heart disease and strokes were linked to eating; apples; pears; citrus fruits; salads; green leafy vegetables (eg lettuce) and cruciferous veg.
People living with depression is increasing
The number of people living with depression is increasing, 18% between 2005 and 2015. In the lead-up to World Health Day on 7 April, which this year will focus on this increasingly important issue, WHO is releasing today a new global report on health estimates on depression. This report provides latest available estimates of the prevalence of depression and other common mental disorders at the global and regional level, together with data concerning the consequences of these disorders in terms of lost health. Reliable, up-to-date estimates of the proportion of a general population affected by different diseases or health conditions is a key ingredient of effective health policy, planning and evaluation.
To read a WHO factsheet on depression, click here
To view the report, click here
For more on World Health Day, click here
E-cigarettes safer than smoking says long-term study
E-cigarettes are less toxic and safer to use compared to conventional cigarettes, according to research published in Annals of Internal Medicine. Scientists at UCL found that people who swapped smoking regular cigarettes for e-cigarettes or nicotine replacement therapy (NRT) for at least six months, had much lower levels of toxic and cancer causing substances in their body than people who continued to use conventional cigarettes. The research was funded by Cancer Research UK.
To access the paper directly, click here
To view the press release, click here
Cancer cases among women are rising six times faster than in men, according to new research.
According to Cancer Research UK, unhealthy lifestyles are responsible for the rise in cancer cases among both sexes - but women are bearing the brunt of the increase. Obesity is one of the factors that can increase the risk of cancers that only affect women, such as womb cancer and ovarian cancer. Cervical and oral cancers are also on the rise in women. Smoking rates are now falling across the UK - but lung cancer figures are beginning to reflect women who took up the habit over recent decades. The charity says that cancer rates will continue to climb nearly six times faster in women than men over the next 20 years.
Draft Belfast Bicycle Network 2017 - Consultation
The Northern Ireland Minister for Infrastructure is committed to increasing the level of active travel and strongly supports improving health and wellbeing for everyone across the region. In this draft Belfast Bicycle Network consultation document, the Minister sets out his plans to develop a quality bicycle infrastructure for Belfast. The Consultation opened on 23 January 2017. Closing date 13 April 2017 at 17:00.
European Cervical Cancer Prevention Week
Women aged 25 to 60 across Ireland are being urged this week to look after their health by making sure they're up to date with their free smear test to help prevent cervical cancer. The campaign marks the beginning of European Cervical Cancer Prevention Week, which takes place from January 24th to 30th. Regular cervical screening can detect changes to the cervix early. Most of the changes detected will not lead to cervical cancer but early detection and treatment of pre-cancerous cells can prevent cancer developing in most cases.
For more details of the Campaign in the Republic of Ireland, click here
For Northern Ireland, click here
Eating certain foods that have been cooked at high temperatures could be linked to cancer, according to health officials
The danger foods include chips, toast, biscuits, crackers, crisps, breakfast cereals (except for porridge), coffee, cooked pizza bases, black olives and cereal-based baby foods. Also on the list are root vegetables such as potatoes, sweet potatoes, beetroot, turnip, swede and parsnips once they have been fried until dark brown or crispy. When cooked at high temperatures (above 120C) a chemical compound forms called acrylamide and studies on mice have shown that high levels of it can cause neurological damage and cancer. Studies in humans have proved inconclusive. However, the US Environmental Protection Agency has said it is "likely to be carcinogenic to humans" and the International Agency for Research on Cancer described it as a "probable human carcinogen".
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Academic Rigor
Dorm Life
Food and Dining
Bang for the buck
Clubs and Activities
Greek Life
Campus Safety
Through just my first semester, I learned more at Prescott College than I did my entire senior year of high school. Sometimes the homework load can feel intense, but I have already seen myself improve as both a writer and an analytical thinker. I have gained knowledge that is useful in daily life as well as the classroom, and often times take trips outside of the classroom to learn through experience. I can truly say there is only one class I feel I am not learning as much as I would like to in since I am academically gifted, a...
To find more tips for prospective students, what to do for fun and whether this school is great for a particular type of student read the 25 reviews for Prescott College
Curious about something that isn't answered here? Feel free to ask Prescott College a question
The whole admissions team was extremely amazing. My admissions, financial aid, and billing counselor were all extremely helpful. I can't wait to attend prescott college in the fall.Read More
Prescott College has provided me experiences I cannot imagine finding at any other college. It is a very unique campus with a commitment to providing passion and personalization to coursework. The faculty, staff and the students at this school are the soul of the college and provide a comfortable, accepting learning community.Read More
I applied to the school, and upon acceptance, was offered a $7,000 dollar per year scholarship, but I have applied to other schools that I have yet to hear from.Read More
Prescott College truly supports students' growth and success in the field of their dreams. This institution encourages students to independently and creatively prosper in their career of choice. This school facilitates the self-empowerment necessary to make a difference in the world, and for each individual to be the best that they can be.Read More
Prescott College is an alternative and innovative expeditionary education establishment that focuses on helping students discover what they love and how they can continue to do what they love successfully for a career. Prescott Colleges focuses in the humanities and outdoors with flexibility to adapt to most students looking at liberal arts colleges.Read More
Prescott college offers an opportunity for students to explore the experiential side of learning. Through the courses offered in the Adventure Education program I am becoming an educator with my students' specific needs in mind.Read More
If you are looking for a school that has small class sizes, enthusiastic professors and fleet of savvy fifteen-seater vans than Prescott College is the school for you! Unlike most colleges Prescott College provides students with extensive hands on and field experience. With many areas of study including Adventure Education, Environmental Studies, Education, Cultural and Regional Studies, Arts and Letters and more, Prescott College provides many unique classes for students to choose from.Read More
This school looks like it has a great Marine Biology program. Very beautiful campus. Perfect spot next to the beach.Read More
Prescott College is for self-directed students. If you are passionate about social justice, the environment, or a broad education in liberal arts and other studies, this school is for you. It provides an abundance of opportunities for students to study as they please and even create their own major.Read More


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Dave White Profile
Dave White
Your Movies.com Man at the Multiplex
Dave White's first movie review was of the animated feature Snoopy Come Home. He was seven years old...Read full profile
Your Movies.com Man at the Multiplex
Dave White's first movie review was of the animated feature Snoopy Come Home. He was seven years old...Read full profile
Him Read full review
Critics scores range from 0 to 100, with higher scores indicating more favorable reviews.
out of 100
Metascore®Mixed or average reviewsbased on a weighted average of allcritic review scores.
Transcendence is a bold, beautiful, sometimes confounding flight of futuristic speculation firmly rooted in the potential of today's technology.
Read Full Review
Ambitious to a fault, this cautionary fantasy about artificial intelligence has so much on its muddled mind, and so little sense of dramatic grounding, that it grows ever more preposterous before lurching to a climax that's utterly unfathomable.
The story soon devolves into a far-fetched, futuristic snooze-fest that often defies its own logic. Characters' motivations are rarely clear, and allegiances shift with no explanation.
After an intriguing start, Transcendence — aka "The Computer Wore Johnny Depp's Tennis Shoes" — offers roughly the same level of excitement as listening to hold music during a call to tech support.
Pfister, who, like his mentor Nolan, adamantly continues to shoot on film (not digital), shows a sure hand at staging scenes, creating visuals and setting a tone -- if only all the diverse elements here fit comfortably under the same tent.
See all Transcendence reviews at Metacritic.com
OK for kids 14+
Dark, pretentious sci-fi thriller tackles big questions.
What Parents Need to Know
Parents need to know that Transcendence stars Johnny Depp as Dr. Will Caster, a brilliant researcher in the field of artificial intelligence who's shot by a band of anti-technology extremists and finds another life within an experimental supercomputer. As the scientist's mind expands into new frontiers, he starts to devise new ways to cure diseases and heal the environment ... but he also pursues his own less-altruistic agenda. This is pretty intense, brooding end-of-the-world material, which is too much for younger viewers. Expect explosions, gunfire, and other action sequences, as well as infrequent swearing (including "s--t"), a little kissing, and a few bar scenes with adults drinking.
Messages: Absolute power corrupts, and we need to be careful about how we use technology. While a brilliant scientist/artificial consciousness thinks he's trying to improve the world, it soon becomes clear that he won't tolerate any interference.
Role models: A woman is willing to do almost anything to save her beloved, dying husband, even if it means transferring his consciousness into a powerful computer network. And when she realizes that her actions have dire, unintended consequences, she's willing to make a huge sacrifice in an attempt to make things right.
Violence: Several scenes feature soldiers attacking a compound, using machine guns and explosive devices that turn a large field of solar panels into debris. A character is assaulted by two men and then kidnapped. Another man is badly beaten, and his battered and bloody body is shown in detailed close-ups.
Sex: A few kisses between a husband and wife.
Language: Occasional use of the word "s--t."
Consumerism: One character uses several Apple products, including an iPhone and an iPad. She also drives a Subaru. Some city signage is visible, including an ad for Citibank. A fictional copy of Wired magazine features Depp's character on the cover.
Drinking, drugs and smoking: A few scenes show adults drinking in bars or having wine with meals.
An independent nonprofit dedicated to providing families the information they need to help kids thrive in a world of media and technology.
© Common Sense Media Inc. 2010. All rights reserved.
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
Copyright © 2018 FANDANGO MOVIES.


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2013 Baseball
Niermann named Third Team All-Region
Kyle Niermann named All-Mideast Region by D3Baseball.com
May 21, 2013
BLUFFTON, Ohio - Bluffton senior Kyle Niermann (Napoloeon) was one of eight Heartland Conference baseball players to be recognized by D3Baseball.com following the 2013 season. Niermann became Bluffton's first baseball player to earn D3Baseball.com All-Mideast Region honors. A First Team Heartland Conference selection for the past three seasons, Niermann was named Second Team All-Mideast Region by the ABCA as a junior.
Leading the HCAC and coming in 12th all-time at Bluffton with a blistering .438 batting average, Kyle Niermann leaves an indelible impression on the record books and baseball program following his storied career with the Beavers. He led the Beavers to 19, 19 and 21 wins which all set or matched the school record for victories in his final three seasons at Bluffton. His school-record 71 hits place him sixth in the country and the top five have all played more games than Niermann. He is the only Beaver to put together three seasons of at least 60 hits. Niermann's 37 runs scored, 15 doubles and 90 total bases all place him in the top 10 for a single season. The dean of Bluffton hitting fanned just seven times this season in over 180 plate appearances, or less than four percent of the time.
Niermann became Bluffton's most prolific hitter midway through his final campaign and never slowed down, pushing the school record for hits to 248 and dropping 2012 graduate Tyler Stephenson (215) to #2 all-time, just one season after he went around Brad Buckingham and Tony Moore who shared the mark with 168 safeties. His .391 career average is seventh all-time while his .535 slugging percentage places him 13th. He finished his career in the top five all-time for games played (146), games started (145), at bats (634), runs scored (142), doubles (49), triples (9), RBI (118), total bases (339). His at bats and total bases are tops all-time for the Beavers. Niermann was also outstanding on the bases and in the field. His 25 stolen bases are seventh all-time, while his .988 fielding percentage tied him for 11th all-time.
Bluffton crossed the 20-win barrier with a 21-18 mark for the most victories in school history following a season that saw the Beavers complete their first-ever sweep of Mount St. Joseph and win their first Heartland Conference series with Rose-Hulman since the Engineers joined the HCAC in 2006-07. The Beavers just missed out on their first-ever trip to the Heartland Conference tournament while earning series victories over four HCAC teams in 2013.


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What do you get for the girl who can make anything? Cool tools and savvy supplies to help her do so, of course! From the world's cutest sewing machine to a colorful camera for capturing finished projects, we've found a stellar selection of DIY-approved gifts.
And while you're at it, allow us to suggest a perusal of Teen Vogue's best do-it-yourself tutorials. (See, we've got you totally covered!)


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WestJet Announces Direct Flight from Calgary to Belize
Posted on Monday, July 24, 2017
Great News! Belize just got closer for Western Canada.
We are very excited to share this news from WestJet. This morning July 24th, WestJet announced a direct non-stop service from Calgary to Belize for the winter.


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My former teacher E. D. Hirsch has been working for decades now to effect a transformation of American education. His career path has been a curious one. He began as a notable literary theorist whose book Validity in Interpretation articulated a strong defense of authorial intention as the proper standard of validity in interpreting literary texts. (The book has been much-loved by evangelical biblical scholars, many of whom seem not to have noticed that Hirsch's arguments for authorial intention are purely pragmatic: he contends that literary scholars have a professional need for some standard of interpretative validity, so he just chooses authorial intent as the most effective option.)
But then, in the 1970s, Hirsch got interested in the teaching of English writing at the university level. Why do so many incoming college students write so poorly? And what can be done about it? These questions led him back a stage: What were these students taught in high school and before?
And that line of inquiry led Hirsch to the path he has been on ever since, and that he first pursued in his best-known book, Cultural Literacy: how to fix what's broken in American education at the primary and secondary levels.
In a new article in City Journal, he makes a cogent case that educators need to give special and focused attention to increasing children's vocabulary, because of the very strong correlation between an extensive vocabulary and academic and economic success later in life.
Because vocabulary is a plant of slow growth, no quick fix to American education is possible. That fact accounts for many of the disappointments of current education-reform movements. For example, the founders of the KIPP charter schools, which have greatly helped disadvantaged children, recently expressed concern that only 30 percent of their graduates had managed to stay in college and gain a degree. But note that KIPP schools typically start in fifth or sixth grade, and while KIPP's annual reports show that their students achieve high scores in math, they score significantly lower in reading. I interpret those facts to signify that middle school is too late to rectify disadvantaged students' deficits of vocabulary and knowledge. Word-learning is just too slow a process to close those initial gaps in time for college. The work of systematic knowledge- and word-building has to begin earlier.
I would make three practical recommendations to improve American students' vocabularies, and hence their economic potential: better preschools, run along the French lines; classroom instruction based on domain immersion; and a specific, cumulative curriculum sequence across the grades, starting in preschool. Of these, the last is the most important but also the toughest to achieve politically.
It's hard to achieve politically in part because people like Hirsch get stigmatized by the educational establishment as "reactionaries" because they want to establish stronger and more consistent standards for achievement.
It's worth remembering that Hirsch's Cultural Literacy appeared in the same year as Allan Bloom's incendiary Closing of the American Mind and that the two were frequently lumped together as "conservative" responses to educational chaos. Bloom was a conservative indeed, of a highbrow and elitist stripe, but Hirsch has always been a committed political liberal: he has consistently stated that he wants a stronger educational system in order to address inequality and give the poor, marginalized, and disenfranchised a better chance to succeed in American society.
Hirsch's preferred policies may be right or may be wrong — that's a debate for another day — but to dismiss them because of some purported but fictional "conservatism" is to practice the kind of epistemic closure that paralyzes our society in those very arenas where we most need creative change. At the very least this article, like everything else Hirsch has written on education in the past twenty-five years, is very much worth reading in full and reflecting on at length.


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Donald C. Brannan, 91
Donald Clayton (Sam) Brannan, 91, died at Great Plains Regional Medical Center in North Platte Feb. 2,2011. He was born Sept. 11, 1919, at Red Cloud to Clarence and Opal (Eggleston) Brannan. He went to grade school in southern Cherry County, and one year of high school in Medicine Bow, Wyo. His parents separated when he was 14. He spent his teen years working on ranches in the Mullen area. Most of the time at the Eck Cox ranch, where he was given the nickname of "Sam." He volunteered for the military service June 4, 1941, and was discharged with the rank of SGT in the Army Jan. 30, 1945. His last year of service was in Hawaii and new Guinea. He returned to Douglas, Wyo., and worked road construction and also at a coal mine. July 12, 1947, he married Blanche D. Powell. They moved back to the Don Cox ranch north of Mullen, where sons Jim and Bill were born. In 1953, they moved to the Erick Ericksen ranch where daughter Bonnie was born. They later moved into Mullen for school. He leased the Alice Giles and Swede Mathews land and raised Angus cattle. He and Blanche move to North Platte in 1999, to be near family. For the last two years of his life he returned "home" and resided at the Pioneer Memorial Nursing Home in Mullen. He enjoyed going to the Denver Sock Show and to his Army reunions in Springfield, Mo. He liked to travel, go fishing and spend time with family and friends. He was preceded in death by his wife, Blanche; his parents and stepfather; sister, Maxine Land and Linda McKibben; brothers, Kenneth and Wayne; and sister-in-law, Betty Brannan. He leaves behind his sons, Jimmie (Ramona) of North Platte, and Billie Brannan of Mullen; daughter, Bonnie (Alan) Little of North Platte; grandchildren, Tim Brannan of Hershey, Nicole (Mike) Buchanan of Springview, Dena Brannan of Hershey, Darrin LIttle of Lincoln, and Janelle Little of Cozad; great-grandchildren, Bobbie Jo, Britni and Garrett Brannan of Hershey, and soon to be Baby Girl Brannan, also of Hershey; sister, Donna (Arnie) Compton of Newcastle, Wyo.; brother-in-law, Kenneth McKibben of Douglas, Wyo., and several nieces and nephews. Memorial funeral services were Feb. 7, 2011, at the Mullen Funeral Home, with A.B. Cox officiating.. Burial with Military Honors was in the Cedarview Cemetery at Mullen with Mullen Funeral Home in charge of arrangements. Memorials are suggested to the Cedarview Cemetery.


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Performance-Based Assessment for Middle and High School Physical
Education, Second Edition, helps teachers create assessments and
implement them into the curriculum. The text describes the types of
performance-based assessments, numerous models that can be adapted, and
tools for assessing students. It includes current NASPE standards.
Reference for middle and high school educators in developing and
implementing physical activity programs. Text for education and physical
education majors and for students in technology courses.
Jacalyn Lea Lund, PhD, is an associate professor and chair in the
department of kinesiology and health at Georgia State University in
Atlanta. She has been a teacher educator since 1989 and had 16 years of
teaching experience in the public schools prior to that. She has
presented on assessment at numerous workshops and has taught numerous
classes on assessment in physical education.
Dr. Lund has been a member of the National Association for Sport and
Physical Education (NASPE) for more than 30 years. She was on the
committee that developed the 1995 NASPE content standards for physical
education and has served as NASPE president. In 2009 she received a
Service Award from the National Association of Kinesiology and Physical
Education in Higher Education. She loves spending time with her family,
dancing, reading, and, as she puts it, "having her dogs take her for a
Mary Fortman Kirk, PhD, is a professor of physical education at
NorthernKentuckyUniversity, where she coordinates health and physical
education programs. She also taught physical education at the high
school level for 10 years. Kirk has given many presentations on
portfolios and alternative assessment at conferences, including AAHPERD,
NASPE, and the National Association for Physical Education in Higher
Education. She was appointed by the Kentucky commissioner of education
to serve on the state task force for the development of physical
education assessment and performance assessment of new teachers.
Kirk earned an MA in motor learning and physical education from
MichiganStateUniversity in 1973 and a PhD in motor development and
teacher preparation from OhioStateUniversity in 1989. She is the author
of two books on pre-sport development programs for the National Alliance
for Youth Sports and the Girl Scouts of the USA.
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Locum Dentist - Mablethorpe
Locum Dentist to join our well-established practice in Mablethorpe.
What we do matters. Our customers trust our dentists with one of their most important assets, their smile. Patient care is our passion and we believe everyone deserves a happy and healthy smile, which is why we thrive on having the very best dentists in the industry working with us to ensure we all keep on smiling.
Here at Oasis Dental Care (now part of Bupa) our people are at the heart of everything we do, because we care. We have created environments where people can look forward to coming to work, feel empowered and benefit from working collaboratively with brilliant & talented experts. So working with us isn't just a job, but continuous professional development
This exciting opportunity also offers:
- 2 days per week
- Competitive UDA Rate available
- Great Private earning potential
- Additional discount for utilising Oasis Labs
- Continuous Professional Development
The Practice: Established with 3 surgeries, modern working environment, fully computerised, R4 Software. Experienced longstanding associates, supported by a dedicated Dental Hygienist and a team of qualified professional support staff. Providing a 50/50 mix of NHS & Private, and in addition offering Practice Plan and Oasis Basics.
Oasis Mablethorpe is a well-established three surgery practice, located in the Marisco Medical Centre. This modern environment enables us to offer a holistic approach to patient care. Our modern surgeries are just a short walk from Mablethorpe's sandy beaches.


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Vanessa Hudgens: Halloween Costume Shopping!
Vanessa Hudgens heads to a Halloween costume store on Monday (October 3) in Studio City, Calif.
Earlier in the day, the 22-year-old actress grabbed a smoothie with her younger sis Stella after the two got in a workout at the gym.
PHOTOS: Check out the latest pics of Vanessa Hudgens
Last week, Vanessa and Stella did some more Halloween preparation and stopped by a pumpkin patch.
The two sisters also enjoyed the sunny weather over the weekend with a bike ride around their neighborhood.
FYI: Stella is wearing a tank by Malibu Native. Vanessa is carrying a Linea Pelle bag.
10+ pictures inside of Vanessa Hudgens going to the costume store…


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26 Jul 2009 10:24:31 AM
Video: Ray Mercer Not a Fan of Head Kicks
(Props: MMA Scraps)
Before Ray Mercer became known as the unstoppable heavyweight juggernaut who wrecked Tim Sylvia in 8 seconds, Mercer had a two-fight kickboxing stint in K-1, losing his debut to Musashi by unanimous decision in June 2004. His second bout against Remy Bonjasky at the K-1 World GP 2005 in Seoul was even less successful. We won't spoil the suprise for you, but the fight (if you can call it that) starts at the 3:53 mark of the above video and ends very shortly afterwards. It's pretty sad when losing a match to Kimbo Slice by submission still isn't the low point in your fight career.
Speaking of Merciless, the former WBO boxing champ and Olympic gold medalist may have his next MMA bout booked. American Top Team boxing coach Howard Davis Jr. is in negotiations to put Mercer against old-schooler Marcus "Conan" Silveira in the main event of a December 12th MMA card called "U.S. vs. Brazil," put on by Davis's new Fight Time Promotions company.Read More DIGG THIS