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How to Grow a Perfect Container Garden
Article written by Saturday6TM blogger Steve Asbell from The Rainforest Garden
Whether you'd like to pick fresh herbs right outside your doorstep or have a garden that thrives on neglect, there's a container garden out there just for you. Before you head out to the garden center though, it pays to do a little planning first. First, have fun and dream up your ideal garden and the plants it will contain. Then you'll need to determine where your container design will go, what kind of light it will receive and how often you plan on watering. After that, it's time to plant your living arrangement!
What Kind of Garden do You Want?
Sometimes it's just more fun to come up with your dream garden first and find a place for it later. You can start designing your container combo around your ideal color palette, and choose flowers and foliage that complement the color of your home or outdoor furniture, or select plants that serve a certain purpose. You can decide to use plants that provide seasonal interest with fall colors or use plants with evergreen foliage or berries in winter. You can even make container combinations using houseplants, herbs, vegetables or fruit!
Where Will It Go?
Now that you've gotten excited about your perfect little piece of garden paradise, decide upon a location with the right amount of sunshine to keep your plants happy. For example, vegetables and herbs will have a hard time thriving on a shady balcony, but shade plants like mondo grass (Ophiopogon japonicus) or cast iron plant (Aspidistra elatior) will feel right at home.
Plant tags usually note what kind of sunlight a plant requires by telling you if it needs full sun, part sun/shade or full shade. If the spot is covered in direct sunlight for most of the day (6 or more hours) it's considered full sun. It's considered part-sun if it only receives 3-6 hours of sun a day, and it's full shade if it receives less than three hours of direct sun in the morning or evening. Typically a north-facing wall will receive full to part-shade, a south-facing one will get full sun and an east or west-facing wall will get part-sun. Make a note of which type of light your ideal spot will get, and determine which plants will do well in that situation. Full sun is best for most annual flowers, herbs and vegetables, but part-sun will also suffice for plants labeled as such. There are less options for plants in full shade container gardens, but many foliage plants will do well in a shady spot.
How Much Water?
Just as plants have different sunlight preferences, some require constantly moist soil, while others like it on the dry side. Most plant tags will tell you that a plant requires moist, well drained soil, but it's just a fancy way of saying to use regular potting mix and water enough to keep the soil moist.
If you're forgetful by nature or have a busy schedule, choose plants labeled as 'drought tolerant' such as succulents, trailing lantana, natives and grasses. If you're willing to bring your container garden indoors when the temperature dips below freezing, houseplants such as snake plant (Sansevieria trifasciata), and ZZ plant (Zamioculcas zamiifolia) will survive long periods without water. If it's flowers you want, choose durable ones like crown of thorns (Euphorbia milii) or daylily (Hemerocallis selections).
In addition to using a freely draining potting mix, it's imperative that your container has drainage holes, so that the water doesn't collect and rot the roots of your plants. Placing a saucer under your container is a good way to ensure that water has a chance to get absorbed before draining onto your patio, but you shouldn't let a plant stand in water for long.
How to Design and Plant Your Container Garden
Here are some tips to make your arrangement look cohesive and beautiful. Before planting, step back and make sure that each plant will be visible different vantage points. It will make for a better looking display if the tallest plant is placed in the center or rear of the container, trailing plants are placed at the edge and medium-height plants are placed in-between. Whenever possible, choose multiples of the same plant or at least the same colors so that the arrangement will look full and cohesive. A bunch of randomly scattered plants can look jarring and cluttered.
Now that you've decided upon what kind of garden you can't live without, it's time to get plants and get planting. Before you begin, make sure that all of your plants are watered, since moist soil will make repotting easier for the new transplants. Choose a container large enough to accommodate the plants you've chosen and without removing the plants from their pots, arrange them to make sure they fit. Now is also a good time to double-check that the plants all like the same amount of sunlight and water.
Fill the container almost all the way with potting mix, leaving just enough room to accommodate the plants. Remove the plants from their pots, and inspect the root-balls within. Use a sharp knife to break through the bottom inch of extremely root-bound plants, so that new roots will grow after planting. If the rootballs have problems such as rotting roots or pests, return them to the garden center for healthy replacements.
Once the container is nearly filled with potting mix, place each plant in the container and add more soil beneath the plants, so that the crown (where the stem meets the soil) of each plant is level. Continue adding soil around the rootballs until it appears to be level with the crowns of each plant and water the whole container thoroughly to help the potting mix settle in. Continue adding soil around the rootball of each plant until level.
Add some slow-release fertilizer (compost tea, granular or otherwise) to the surface of the potting mix according to label instructions. Some mixes already have fertilizer built in, but you will still need to refresh the planting with another feeding after a couple of months. Since it takes time for the plants to put out deeper roots, you will need to pay special attention to watering for a week or two after planting.
Don't be discouraged if one or more of the plants struggles or dies outright! The other plants will grow to take their places, or you can replace them with new plants as desired. Unless you specifically choose plants that will last a long time, it's perfectly normal to replant your container garden after a few months. If it happens to still look great after that, then you've done exceptionally well and can give yourself a pat on the back!


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Mark OrtmannFree Agent
Offensive Tackle
Ht: | Wt: 295
News | Stats | Stat vs. Team | Targets | Injury | Depth Chart | Roster
|Falcons | Two players waived
Sat, 28 Aug 2010 13:13:49 -0700
The Atlanta Falcons have waived CB Gabe Derricks and OT Mark Ortmann, according to D. Orlando Ledbetter, of The Atlanta Journal-Constitution.
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|| Source: The Atlanta Journal-Constitution - D. Orlando Ledbetter
|Patriots | Work out three players Tuesday
Tue, 03 Aug 2010 12:35:15 -0700
The New England Patriots worked out unrestricted free-agent OL Darnell Stapleton (Steelers), C Eric Ghiaciuc (Browns) and OT Mark Ortmann (Panthers) Tuesday, Aug. 3, a source told FOXSports.com's Adam Caplan.
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|Panthers | Six players waived
Thu, 17 Jun 2010 10:09:32 -0700
The Carolina Panthers have waived TE Andrew George, PK Blake Haudan, SS Matt O'Hanlon, OT Mark Ortmann, PK Aaron Pettrey and RB Daniel Porter, reports Steve Reed, of CarolinaGrowl.com.
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|Panthers | 10 UDFAs signed
Mon, 26 Apr 2010 12:09:36 -0700
The Carolina Panthers have signed undrafted free-agent OG Noah Franklin (Oklahoma State), OG Kurtis Gregory (Missouri), P Blake Haudan (Minnesota), OG Ray Hisatake (Hawaii), FB Reshawn Jackson (Virginia), SS Matt O'Hanlon (Nebraska), OT Mark Ortmann (Michigan), PK Aaron Pettrey (Ohio State), RB Daniel Porter (Louisiana Tech) and LB Sean Ware (New Hampshire), reports Panthers.com. Terms of the contracts were not disclosed.
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subset: commoncrawl


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January 17, 2013 00:01 ET
NEW YORK, NEW YORK--(Marketwire - Jan. 17, 2013) -
Editors Note: There is a photo associated with this press release.
Peter Leeds, author of "Invest in Penny Stocks" [John Wiley & Sons], publisher of the Peter Leeds penny stock newsletter, and public speaker, has announced a site dedicated to assisting investors to navigate the waters of speculative shares.
Located at www.PennyStocks.org, the extensive information is geared towards helping individuals avoid the numerous pitfalls among low-priced stocks, while enabling them to practice the most effective techniques when conducting their own research.
"Penny stocks get a bad name," mentions Leeds. "When investors make some of the common mistakes inherent in the speculative markets, they lose money. With a little simple education, those same investors can realize how easily avoidable their error was in the first place, and then they are able to discover methods to find high quality investments from among the thousands of penny stocks."
Based upon nearly two decades of experience, the information available at www.PennyStocks.org was consolidated and refined by members of the Peter Leeds team and is now provided to the public at no cost. Billing itself as "the straight facts about penny stocks," the free web site contains over 200 pages of specific and directed information.
Asked which individuals the site will help the most, Leeds comments, "I wish this information was available when I was getting started in penny stocks. It would have helped me from making the major mistakes which cost me all of my money at first, before I learned to trade penny stocks properly."
Leeds expresses that penny stocks are popular investments for unethical promoters and scam artists, so investors should be extra cautious when trading smaller shares. He urges all individuals to protect themselves by avoiding free stock pick websites, and to only trade in high quality penny stocks which trade on the best stock markets, like the OTC-BB, Amex, or NASDAQ. He also urges individuals to conduct a full due diligence review into any shares they are thinking about buying, as detailed on www.PennyStocks.org.
Leeds mentions that neither he himself, nor any of his team members, have ever accepted any compensation from the penny stocks they profile to their subscribers.
To view the photo associated with this press release, please visit the following link: http://www.marketwire.com/library/20130116-PeterLeeds800.jpg.
Pennystocks.netTammy firstname.lastname@example.com
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Penny Stock Analyst Peter Leeds


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Information For
Liberal Studies Program
The Liberal Studies Program is the common curriculum taken by all students in the seven undergraduate colleges of DePaul University. Overall, the program is designed to develop students' writing abilities, computational and technological proficiencies, and critical and creative thinking skills. Some liberal studies courses introduce the institution's unique Catholic, Vincentian, and urban mission and identity, and may include opportunities for community service. While the liberal studies curriculum itself is quite varied, the program as a whole shares these four learning goals: 1) Knowledge of Human Cultures and the Physical and Natural World, 2) Intellectual and Creative Skills, 3) Personal Responsibility and Social Transformation, and 4) Integrative Learning.
Unlike a student's chosen major, which offers depth of knowledge in a single focused field, a liberal studies education provides breadth of scholarship across many different areas of study. At DePaul, faculty from virtually every department, interdisciplinary program, and college help to teach the over 1400 different courses from which students can choose to meet their liberal studies requirements. This wide spectrum of participation on the part of students and faculty alike contributes to a strong sense of intellectual community at DePaul, and a shared commitment to its mission and values.
Lincoln Park Campus990 W. Fullerton Ave,Suite 4200Chicago, IL 60614(773) email@example.com
Lincoln Park Campus2312 N. Clifton Ave, 117Chicago, IL 60614(773) email@example.com
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Aileach FC
The Aileach underage teams have started the season in impressive fashion,please continue to attend training and work hard to keep up our impressive form.
Aileach FC
The Aileach underage teams have started the season in impressive fashion,please continue to attend training and work hard to keep up our impressive form.
Charlie O Donnell Cup Final
Aileach FC 3
Glengad United 2
The Charlie O Donnell cup final took the curtain down on the 2017-18 season at Maginn Park on Sunday with Aileach and Glengad locking horns again and it was a brilliant game. Glengad pressed further up the field from the start after last weeks defeat. After a bright opening Aileach created the first chance on 3 minutes when a superb Thomas McMacken through ball released Gareth McGlynn but he fired over from just inside the area. Glengad replied and a burst from the back by John G McLaughlin released Terence Doherty on the left and he picked out Seamus Doherty centrally but his driven effort was straight at Peter Devlin. Aileach broke the deadlock on 19minutes when McGlynn spread a free kick out wide to Darren McMonagle on the right and his brilliant cross was slotted home by Ronan Coyle at the back post.
Aileach 3-2 Glengad Ron8 Coyle 2, Darren Mc Monagle (Aileach) Seamus Doherty, Stephen Mc Laughlin ( Glengad)
Aileach and Glengad meet for a third week in a row in today's Charlie O'Donnell Cup Final it's a repeat of last week's Buncrana Credit Union cup final there is very little between these two teams all season and today's game is hard to call both have won two trophies this season and a treble is on the cards for some one of the teams today a game worth watching
Inishowen Football League 20/5/18
Buncrana Credit Union Cup Final
Aileach FC 1
Glengad United 0
Played in Maginn Park on Sunday afternoon in overcast conditions this was an excellent game with Aileach thoroughly deserving their success. Aileach had the first opportunity in the 5th minute after Darren McMonagle 's cross was chested down by Ronan Coyle to Thomas McMacken but he blazed over from fifteen yards.
Aileach FC V Glengad United
Terence Moyne assisted by G McLaughlin & E Doherty
Saturday 12th May
Hannon Greene Insurances Fr O Gara Cup Final
Dunree United 1
Rasheney FC 2
Played in glorious sunshine at Maginn Park on Saturday evening this was the proverbial game of two halves with Dunree dominant in the opening forty five minutes but Rasheney came storming back in the second
Inishowen Football League 6/5/18
Jackie Crossan Premier Division 6.45pm (Played Tuesday)
Buncrana Hearts 3
Greencastle FC 6
Played in constant rain on Tuesday night the hearts started well with Ryan Currans powerful effort well saved by Dylan Doherty. The home side broke the deadlock on 16 minutes when Kieran McDaid broke through the visitors defence to round Doherty and slot home.
Sunday 6th May
Jackie Crossan Premier Division 2pm
Glengad 3-1 Greencastle Terence Doherty 2, Stephen Mc Laughlin (Glengad) Nigel Mc Monagle (Greencastle)
Aileach 6-1 Culdaff Ronan Coyle 3, Anthony Doherty, Gavin Doherty, Paddy Curran (Aileach) Brendan Mc Laughlin Pen (Culdaff)
Jackie Crossan Premier Division Relegation Play Off
Maginn Park 2pm ET & Pens
Illies Celtic 1-1 Carn FC Paddy Doherty (Illies) Aaron Mc Carron (Carn) Gone to Extra Time
Strand Hotel Division One 2pm
Rasheney FC 2-4 Redcastle John Grant,Kevin Noone (Rasheney) Jack Mc Connolouge, Alan Clarke, Aaron Nash, Odie Mc Colgan (Redcastle)
Inishowen Engineering Division 2 A 11am
Glengad Res 4-0 Moville Res


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Listen To "Tattoo Session" By Kevin Gates
With his Islah album being readied for a December 11th release, Kevin Gates keeps the streets flooded with new material. Today we get a new record titled "Tattoo Session" from the "I Don't Get Tired" rapper.
With his Islah album being readied for a December 11th release, Kevin Gates keeps the streets flooded with new material. Today we get a new record titled "Tattoo Session" from the "I Don't Get Tired" rapper.
After dropping the official video for "Let It Sing" last week, Kevin Gates returns with a brand new single titled "Therapy Shit". His Chained…
Kevin Gates "Let It Sing" (Official Music Video)
Kevin Gates drops a brand new visual for his single "Let It Sing". The record appears on his Chained To The City EP, which…
Kevin Gates "Change Lanes" (Official Music Video)
Kevin Gates returns with his first official music video since being released from prison for "Change Lanes." The song appears on his new EP,…
Kevin Gates "Chained To The City" (EP)
Rapper Kevin Gates is out of jail and working on new music. Today he delivers his new EP, Chained To The City. Stream the…
DJ Kay Slay – Cold Summer (Feat. Kendrick Lamar, Mac Miller, Kevin Gates & Rell)
Legendary DJ Kay Slay brings together Kendrick Lamar, Mac Miller, Kevin Gates, and Rell on the new single "Cold Summer." The song appears on…
Even from behind bars Kevin Gates is still releasing new music. Today he liberates a recording titled "No Love." Listen to the record below…
DJ Kay Slay – Wild One (Feat. Rick Ross, 2 Chainz, Kevin Gates, & Meet Sims)
Legendary New York disc jockey DJ Kay Slay is dropping a new album titled The Big Brother. The project drops on August 18th. The…
Kevin Gates Sentenced To 30 Months In Jail
Kevin Gates is facing 30 months in jail after being sentenced for felony gun possession. Prior to this sentencing the promising rapper was doing…
The Fate of the Furious: The Album (Stream)
To coincide with the release of Vin Diesel and The Rock's new movie, The Fate of the Furious, here is the film's rapper heavy…
Kevin Gates remains incarcerated but it's not stopping him from releasing new music. Today he releases his new single "What If". Listen below.
Kevin Gates – Drive (Feat. OG Boobie Black)
Digital Trapstars give us a new record from Kevin Gates and OG Boobie Black titled "Drive".
FDAMusic – I Know It (Feat. Kevin Gates)
Kevin Gates makes an appearance on this new song by FDAMusic titled "I Know It".
Kevin Gates was the musical guest on Conan last night and he performed 2 cuts from the album Islah. Check out Kevin's performance above.
OT Genasis – Cut It (Remix) (Feat. Young Thug & Kevin Gates)
OT Genasis's "Cut It" single gets even hotter thanks to a dope new remix featuring Young Thug and Kevin Gates.
Controversial rapper Kevin Gates teases his forthcoming Murder For Hire 2 project with the release of a new track titled "Off The Meter".
Kevin Gates – Not The Only One (Official Music Video)
" With his debut album Islah in stores now, Kevin Gates liberates the official video for "Not The Only One". Grab the project on…
Amir Obé "Holy Shit" (Official Music Video)
Robb Banks "Cloverfield 3" (Mixtape)
Young Thug "Gain Clout" (Official Music Video)
Young Thug "Slime Language" (Album Stream)
Tory Lanez & Bryson Tiller "Keep In Touch"
Lil Yachty "66" (Feat. Trippie Redd) (Official Music Video)
Quavo "LAMB TALK" (Official Music Video)
ASAP Ant & ASAP Rocky "Mario Kart"


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Mila Kunis blasted an Allure magazine reporter when he opened a recent interview with the movie star by asking her about boyfriend Ashton Kutcher.
The journalist showed the Black Swan actress a photo of herself with her former That '70s Show co-star and asked for a comment on the relationship, but Mila Kunis had other remarks in mind.
She scolded the reporter, stating, "I didn't think this was going to be about my friends... (or) who I'm dating, or who I may have ever dated."


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Main Site - :: Why Won't God Heal Amputees? ::
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Only then did masked figures with guns storm the crowd, shouting, "Get on the fucking ground! Get down, get down!" ... Some forty Detroit police officers dressed in commando gear ordered the gallery attendees to line up on their knees, then took their car keys and confiscated their vehicles, largely on the grounds that the gallery lacked the proper permits for dancing and drinking. (More than forty cars were seized, and owners paid around a thousand dollars each to get them back.) "I was so scared," Wong told me. At first, she thought the raid was an armed robbery. "Out of the corner of my eye, I could see Paul getting kicked in the face." In the dimly lit security footage, the scene looks like something out of a thriller about Navy SEALs. Paul said, "I was scared for my life."
Later, she learned that cash-for-freedom deals had become a point of pride for Tenaha, and that versions of the tactic were used across the country. "Be safe and keep up the good work," the city marshal wrote to Washington, following a raft of complaints from out-of-town drivers who claimed that they had been stopped in Tenaha and stripped of cash, valuables, and, in at least one case, an infant child, without clear evidence of contraband.
On the front page of my local paper today is an article about our local police department needing a $300,000 armored vehicle.
Quote from: Nick on August 20, 2013, 09:38:09 AMOn the front page of my local paper today is an article about our local police department needing a $300,000 armored vehicle.did they say for what reason?
On July 15, the Wisconsin Department of Natural Resources (DNR) sent 13 law-enforcement officers to execute a paramilitary raid on a no-kill animal shelter in Kenosha. The crime? The shelter was harboring a fawn that had been abandoned by its mother and named Giggles by shelter volunteers. The shelter intended to turn the animal over to a wildlife reserve the next day, but that was not good enough for the DNR. Wisconsin law forbids the possession of wildlife, so DNR sent the heavily armed team to capture and euthanize Giggles.Eleven days later and less than 100 miles away, staff at a nursing home in the Chicago suburb of Park Forest called paramedics after 95-year-old World War II veteran John Wrana, suffering from a delusional episode, refused medical treatment. The paramedics in turn called the police, which further agitated Wrana, who threatened them with his cane and a knife. The police responded by shooting Wrana with stun guns and bean bags fired from a shotgun. Wrana died from internal bleeding shortly thereafter....continued
Being a police officer does not give carte blanche to do as you like.
Quote from: jaimehlers on February 11, 2014, 02:45:55 PMBeing a police officer does not give carte blanche to do as you like.So you say. Evidence seems to suggest otherwise.
That's pretty disgusting. As the dog's owner said, what if he'd missed, or the bullet had ricocheted? It could have hit a child inside the house.Being a police officer does not give carte blanche to do as you like.
New Hampshire state representative J.R. Hoell has introduced state legislation that will require police departments to get approval from citizens at a town hall meeting before they buy military-style gear. The bill, called the Police Equipment and Community Engagement (PEACE) Act, was prompted by the city of Concord buying its police department an armored assault vehicle, a decision justified in part by the police department's stated need to fight protest groups such as Occupy. ...[continues]
When Christopher Roupe answered the door last Friday, he probably didn't think death would be waiting on the other side. But that's exactly what the 17-year-old ROTC student found after the police officer outside mistook his Wii controller for a gun, a lawyer for his family says. Roupe was killed Friday night after an officer arrived at his mobile home in Georgia to deliver a probation violation warrant for the teen's father. As the officer tells it, Roupe was holding a gun when he answered the door. But Cole Law, who is representing Roupe's family, disagrees."We don't know where [the claim that he had a gun] came from," Law told WSBTV in Atlanta. "The eyewitnesses on the scene clearly state that he had a Wii controller in his hand. He heard a knock at the door. He asked who it was, there was no response so he opened the door and upon opening the door he was immediately shot in the chest."(continues)
http://www.rawstory.com/rs/2014/02/21/austin-police-drag-jogger-to-car-screaming-after-jaywalking-without-id/cops in Austin, Texas arrest a woman out jogging for not providing ID. Gun owners, is this the government tyranny you think your guns are supposed to protect us from? If so, then where the fck are you guys? If not, then what the fck is tyranny?
Actually it doesn't. One could conceivably be all-powerful but not exceptionally intelligent.
Quote from: screwtape on February 21, 2014, 10:20:00 AMhttp://www.rawstory.com/rs/2014/02/21/austin-police-drag-jogger-to-car-screaming-after-jaywalking-without-id/cops in Austin, Texas arrest a woman out jogging for not providing ID. Gun owners, is this the government tyranny you think your guns are supposed to protect us from? If so, then where the fck are you guys? If not, then what the fck is tyranny?You don't want to know, you just want to tell me I am wrong.
So. Either gun advocates who use that argument do not think this is tyranny OR they are full of shit. I am just trying to figure out which. I am pretty sure it is the latter. But I'm asking. If I recall correctly, Dante considered it time to go shoot himself some politicians (and ostensibly cops) when elections were officially cancelled
and "they" were coming for his guns. It's always when they come for the guns.
my gun fail thread. This one is about our militarized police.
Anyway, I think that is rather a high bar and never going to happen. You can have a tyranny without taking the guns and cancelling elections.See, I do think we are living under tyranny. But it is a soft tyranny. It is not a kick-in-your-door kind (unless it is, like many of the links in this thread). It is more of a we-can-do-whatever-we-want kind, justified by security. I think something needs to be done. I would prefer it be on a political level. In fact, I think it has to be.


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MARS HILL, N.C. – The Mars Hill Lions defeated King Men's and Women's Swimming and Diving in Saturday's dual meet by a combined score of 192-47. King was led by Kelsey Wiese and Rachel Fuller who both earned two individual victories, Saturday afternoon.
Kelsey Wiese, a junior from Gallatin, Tenn., earned victories in the 100-yard backstroke and the 50 free events. In the 100 back, she clocked in a time five seconds faster than the second-place finisher, touching the wall in 1:03.09. In the 50 free, she edged out Taylor Bugg by 0.59 second for the win (26.43).
Freshman Rachel Fuller (North Augusta, S.C.) ruled the fly events with wins in the 200-yard butterfly and the 100-yard butterfly. In the 200, she was over three seconds faster than Elle Grier, finished first with a time of 2:26.96. Her 100 fly time of 1:06.50 earned her second individual victory of the day, again logging in a time more than three seconds faster than the next nearest finisher.
The 200-yard freestyle relay team consisting of Kelsey Copeland, Wiese, Sara Hennies, and Fuller were narrowly edged out by Mars Hill by 0.41, good for a second-place finish in the event. Shirley Langford placed second in the 100 breast (1:19.01).
Despite the success by Fuller and Wiese, the Lady Tornado fell to the Lions, 90-31.
The men were also on the losing side of their dual with Mars Hill, falling 102-16. Reynold Thibideau (Titusville, Fla.) placed second in the 100 back (59.65), finishing 0.74 behind the event winner from MHC. He also took second in the 200-yard IM (2:10.20). Also earning second-place honors was Christopher Nochowicz in the 500 free (5:43.18).
Both Tornado teams will be back in action on Jan. 26 when they go to Union College for a 4 p.m. dual meet.


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Charges were filed against Harry Van Hopper of Tecumseh Thursday afternoon.
Charges were filed against Harry Van Hopper of Tecumseh Thursday afternoon.
Hopper was arrested Sept. 27 after a search of his home Sept. 26, Tecumseh Assistant Police Chief J.R. Kidney said.
Tecumseh Police assisted the U.S. Postal Inspection Service, after the inspection service received complaints about Hopper allegedly receiving child pornography through the mail, Kidney said.
The two charges against Hopper include aggravated possession of child pornography and possession of child pornography. Both counts are felonies. If found guilty, Hopper could be sentenced to life imprisonment.
Because the evidence was sent through the mail, it could be a federal offense, Kidney said.
"There is a strong possibility that these charges may be transferred to federal court," he said.
But Tecumseh police decided to search his house and arrest him to "get him off the streets," Kidney said.
Evidence found at the residence included photos of young boys in the nude engaged in sexual acts, Kidney said.
He estimated the boys were likely between 10 and 12 years old.
While charges have been filed, Hopper has bonded out of jail with a $250,000 bond. No other hearings are currently scheduled.
"It's still under investigation," Kidney said.


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Magic Kingdom Resort Area
Disney's Grand Floridian Resort & Spa
Fine/Signature Dining
When you book a Disney vacation, you may opt to purchase a Magic Your Way Vacation Package that includes one of our Disney Dining Plans. Each dining plan provides a set of entitlements you can redeem at select Walt Disney World dining locations.
Refer to your specific dining plan for the number of entitlements require per person for this location. Ranges mean that entitlements vary based on factors—including seating location, season or time of day. To learn the specific number of entitlements, you can call us at (407) 939-5277, visit a location or check availability online.
Please note: Guests who wish to use their Disney dining plan for dinner shows must book category 2 or 3 seating.
|Disney Quick-Service Dining Plan
|Disney Dining Plan
|Disney Deluxe Dining Plan
|Disney Quick-Service Dining Plan
|Disney Dining Plan
|Disney Deluxe Dining Plan
Enjoy American cuisine infused with Mediterranean flavors, plus an award-winning, international wine list.
Savor vibrant Mediterranean-style dishes in this lively, inviting restaurant.
Wrought-iron railings resemble vineyard grapevines, while Old World furnishings and mosaic-tiled floors contribute to the warm décor. Some tables look out onto the manicured courtyard of Disney's Grand Floridian Resort & Spa, while others let you peek into the bustling onstage kitchen.
Fresh, seasonal ingredients influence the oft-changing menu. Begin your meal with crispy risotto, sautéed shrimp or the Cítricos crab salad. Then, delight in mouthwatering specialties like scallop risotto, quinoa and provençale ratatouille, or oak-grilled filet of beef.
For a sweet ending, indulge in such decadent desserts as warm chocolate-banana torte, cheesecake and tropical fruit crème brûlée.
Reservations are recommended and can be made up to 180 days prior to your visit.
The award-winning wine list includes a host of epic wines, sold by the ounce using the latest technology in order to insure both freshness of product and a first-class experience. Many wines are available by the glass, and sommeliers are on hand to suggest wine pairings.
Meet the chef during an intimate, multi-course dinner at Cítricos—prepared with Mediterranean flair and paired with an assortment of award-winning wines.
Unwind within the Mediterranean ambiance at this cozy bar where you can enjoy international wines, cocktails, artisanal beers and seasonal tapas.
Guests are asked to adhere to the minimum dress code requirements at this Signature Dining experience. Dressier attire is also welcome. Please explore the minimum dress code requirements:
Men must wear khakis, slacks or dress shorts and collared shirts. Jeans may be worn if in good condition. Sport coats are optional.
Women must wear Capri pants, skirts, dresses or dress shorts. Jeans may be worn if in good condition.
Not permitted are tank tops, flip-flops, swimsuits, swimsuit cover-ups, hats for gentlemen, cut-offs, torn clothing and t-shirts with offensive language and/or graphics.
Advance reservations are highly recommended. Please book online or call (407) WDW-DINE or (939-3463) up to 180 days prior to your visit.
Get a glimpse into the creative process from the magical minds that make the wonders of Walt Disney World Resort!


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|Shoreham, N.Y.
|High School:
|Shoreham-Wading River
|Back, IM
|Management Science
2011-12: Saw most of her action in the backstroke … third at Tufts (1/21) in the 50 back in 30.16 … fourth in the 100 back at the Wheaton Invitational (2/4) with a time of 1:04.14 … second in the same meet in the 200 back with a 2:18.82 clocking … fifth at Wheaton in the 50 free.
2010-11: Swam in eight different events during the season … most of her action came in the backstroke … season best in the 100 back came against Wheaton (1/6) with a time of 1:05.23 … top 200 back time of 2:21.16 came in the prelims at the NEWMAC Championships.
Out of the Pool at MIT: Majoring in management science … internship with the Right Question Project … research with the Hammond Group, Group Dynamic, Sloan Organization Studies and Lean Advancement Initiative … co-director of the MIT Traditional Medicine Society … Director of Speaker Series … Sigma Kappa sorority … successfully swam the English Channel in August 2011.
High School: A 2008 graduate of Shoreham-Wading River High School.
Personal: Daughter of Youwen Xu and Zizhong Li.


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Grímsvötn Eruption is Over
The Department of Civil Protection has abated emergency levels to normal. Volcanologist Steinunn Jakobsdóttir at the University of Iceland, told AFP News, that no volcanic activity has been detected since 28 May. The Grímsvötn eruption started on Saturday, May 21. After two days of intense activity, the eruption petered out, and was all but over last Wednesday. According to the Department of Civil Protection, there is still considerable clean-up work to be done in the aftermath of the eruption.


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Well we decided we should do some unit testing on our asp.net project. We used NUnit.Asp. i must say the thing works realy great. the whole thing is based on xml document model of the page. so accesing tags and their attribs is preety simple. the only "drawback" i could think of is that every tag you want to get has to have an id. all in all i must say the thing is quite usefull. i build some wrapper classes that we needed and we could test anything you can think of, except javascripts that executed on the client side and opening of popup windows (if anyone knows how to do this let me know). paging, sorting, input, output, how the thing looks, everything. i must say i was quite impressed. we let the thing run overnight, and it found bugs we'd have to spend quite some time finding. the few problems we had were input into a hidden filed didn't work as it has only textbox tester, but this is fixed in a new verion and you have to know the id's for everything so autocreated controls can be a problem.
so i must say i recomend the stuf. now they even have T-SQL Nunit testing and the original NUnit for server side. Taking a look may be worthwhile.
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Meet and chat with Menan singles at Matchmaker.com, our Menan chat rooms contain thousands singles in your local area. Whether you are looking for serious relationships, friendship, or even marriage Matchmaker.com will help you find that special person. Chat with other members with a live video instant messenger or join on of our Menan chat site rooms and meet singles today!
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Central State Hospital Museum
Milledgeville, GA 31061
478-363-1670 | 478-454-1850
Central State Hospital opened in 1842 as Georgia's first public psychiatric hospital. The museum is located on Broad Street in the Old Train Depot across from the CSH Auditorium. It highlights the more than 150-year existence of the hospital. Groups are welcome.
Central State Hospital offers a variety of tour options through appointments.
1. Museum Tours (30 min-1 hour) - Guests can view authentic items that were once used at the world's second largest mental institution, as well as learn about its unique history.
2. Driving Campus Tour (1 hour) - Guests can take a guided tour of the CSH campus, which at one time comprised 20,000 acres. Today the campus sits on roughly 1,750 acres and is Georgia's oldest and largest state psychiatric hospital.
3. Cemetery Tour (45 minutes) - Guests can tour one or all three of our historic cemeteries. All cemeteries are on the National Register of Historic Places, and more than 25,000 individuals are buried in these cemeteries.
Info & Amenities
Admission & Fees
Museum Admission 0.00
Facility Amenities
Free Parking
Guided Tours / Guide Available
General Information
Free Admission
Suitable for Ages
All Ages


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6 Reasons I Hated Formula Feeding and Would Never Do It Again
Hmm. How shall I say this? I should probably put on some sort of protective armour before making this confession -- but here we go: I hated formula feeding. HATED it. Despised it. (There. It's said)
But once I'd started my breastmilk dried up so I had little choice but to stick with it.
I'm totally aware that telling the world that formula feeding just wasn't for me will probably result in my being called a nazi, but I'm willing to do it, because this needs to be said.
When I had my son two years ago, I had every intention of formula feeding him exclusively. He took to the bottle fine and, as my milk came in and then dried up, I told myself a thousand times "I can do this" and swore to stay with it even though my breasts felt engorged with milk.
But then when it consumed my life and made me even more tired and low than I already was, I realized that formula feeding was never going to be my cup of tea.
By that time it would have been so much work to relactate so I didn't. If I ever have another child I'll breastfeed from the beginning and ditch the bottles without hesitation.
I'll reiterate: I hated formula feeding. And here are a few reasons why.
1. It's all I did -- OMG. Those bottles needed constant washing and sterilising and then, because formula milk isn't sterile, I had to make up one bottle at a time making sure that the water was hot enough before waiting for the milk to cool down. As soon as the novelty wore off for family and friends it turned out that I was giving that baby all its feeds anyway and by the time I was done I had to wash up and sterilise again, not to mention all the washing I had to do because everything was covered in formula puke.
2. I needed sleep -- Not being able to safely co-sleep because it's not recommended for formula feeders really took its toll on my overall well being. My husband helped with some of the night feeds until he had to go back to work and then I had to get up every damn night, make the bottle, and then listen to the baby cry while it cooled down.
3. It hurt like the baby like hell -- I have always been jealous of those mums whose newborns can bottlefeed with no discomfort or pain. Mine wasn't one of them. I spent a fortune on different bottles and medicines to try to alleviate the trapped wind and I was constantly burping him, which often made him vomit.
4. My baby was too full – Physiologically, all babies are surprisingly similar, born with tiny stomachs, but because my baby's stomach was stretched with formula as soon as he was born he got used to taking massive meals infrequently. He was very sleepy in demeanor because he was constantly trying to digest foreign enzymes.
5. It made it hard to go out – Almost all my friends formula fed so I knew I'd fit in with the crowd, but what I didn't realise was just how much stuff I'd need to take with me when I wanted to go out with my baby: clean bottles, formula powder, heated water in a flask. And if I ran out of milk while I was out or he vommed it all up I'd have to go back home. Sometimes I bought ready-made formula to make it more convenient, but it costs a bomb.
6. I wanted my body to be used for its natural purpose -- I know it might sound weird, but after being pregnant for nine months, I felt a physical bond with my baby that I wish I'd continued. People who breastfeed tell me that the closeness is something really special and that it turns out that boobs can be for babies and for sex. Who knew?!
Reasons I Hated Breastfeeding at The Stir


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Nigerian Central Bank Governor Ousted
President's Move Sends the Local Currency to a New Low
Nigeria's president ousted the country's outspoken central bank chief, who then accused the government of detaining him without cause and threatening his family members.
Thursday's events sent the nation's currency to a record low and left investors concerned over the government's resolve to fight corruption.
Lamido Sanusi had just four...


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It's been a while since we have done one of these, so there's quite a bit to read here. Let's start with two stories I had a hand in: I talked to Uglydolls co-creator David Horvath and artist Ian McGinty about Uglydolls in general and the comic version they are producing for Viz, and I caught a scoop at C2E2: Mark Waid is launching a Thrillbent Kids site, and he will be publishing Art Baltazar and Franco Aureliani's Aw Yeah! Comics line digitally; the comics are available now via comiXology. Baltazar and Aureliani are the team behind DC's Tiny Titans comics; they have brought in an array of other creators to help with their new line.
All hail Heidi MacDonald, who has written the ultimate article on graphic novels and libraries at Publishers Weekly; check it out and you will see many, many familiar faces.
And over at our fellow blog Connect the Pop, Professor Carol Tilley sets forth five simple things it's easy to overlook about comics.
Gene Luen Yang talks about his Avatar the Last Airbender graphic novels in a video interview at CBR.
Writer Prudence Shen and artist Faith Erin Hicks talk about their new graphic novel, Nothing Can Possibly Go Wrong, at Finding Wonderland.
At Comic Attack, Drew McCabe talks to Emily Martin, the artist behind one of our favorite series here at GC4K, Princeless.
Writer Paul Kupperberg discusses the tangled world of Life With Archie and his new Kevin Keller prose novel with CBR's Alex Dueben.
Katie Cook talks to CBR about her latest My Little Pony micro-series, "Rarity."
Richard Bruton takes a look at last week's issue of The Phoenix, which is available digitally to U.S. readers.
Dan Seitz offers some suggestions for finding good comics for kids.
Reviews: Check out SLJ's latest roundup of graphic novel reviews, including Benjamin Bear, Will and Whit, and more.
Little Willow on Astronaut Academy: Re-Entry (Guys Lit Wire)
Sarah Sammis on Babymouse: Beach Babe (Puss Reboots)
Johanna Draper Carlson on Batman: Li'l Gotham #1 (Comics Worth Reading)
Richard Bruton on vol. 3 of Gum Girl! (Forbidden Planet)
Travis Jonker on Gum Girl! Chews Your Destiny (100 Scope Notes)
Erica Friedman on Hereville: How Mirka Met a Meteorite (Okazu)
Inger on My Little Pony: Friendship Is Magic (The X-Librarian)
Johanna Draper Carlson on Nothing Can Possibly Go Wrong (Comics Worth Reading)
Drew McCabe on Peanuts #7 and Chacha Chaudhary (Comic Attack)
Sterg Botzakis on Poseidon: Earth Shaker (Graphic Novel Resources)
Drew McCabe on Sonic the Hedgehog #247 and Looney Tunes #212 (Comic Attack)
Melissa Fox on Timmy Failure: Mistakes Were Made (Book Nut)
Johanna Draper Carlson on Will & Whit (Comics Worth Reading)


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Preheat the oven to 350 degrees F. Mix the cheddar and pepper jack in a bowl. Spread half of the tortilla chips in the bottom of a deep 12-inch cast-iron skillet or cake pan. Sprinkle with half of the cheese mixture and bake until the cheese melts, about 5 minutes. Top with the remaining chips and sprinkle with the remaining cheese mixture and the black beans. Return to the oven and bake until the cheese melts, about 5 more minutes.
Remove the nachos from the oven and drizzle with the cheese sauce, then top with the chili and guacamole. Top with sour cream, pico de gallo, pickled jalapenos and scallions.
Melt 3 tablespoons butter in a saucepan over medium heat. Add 1 teaspoon each minced garlic and shallot; cook 5 minutes. Stir in 3 tablespoons flour and 1/2 teaspoon salt; cook, stirring, 2 minutes. Add 1/2 cup milk; whisk until thick. Add 1 cup cheddar, season with pepper and stir until smooth.
Mash 2 avocados with a fork. Add 1/4 cup diced white onion, 1/3 cup diced tomato, 4 teaspoons chopped cilantro, 1 tablespoon lime juice, 2 teaspoons minced jalapeno, and salt and pepper. Press plastic wrap directly onto the surface and refrigerate until ready to use.
Photograph by Kat Teutsch
Courtesy of Food Network Magazine
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Get a sneak-peek of the new Food Network recipe page and give us your feedback.See it Now!


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Please use the list below or call the campus main office at 806-326-4900 for assistance with contacting non-instructional staff members not listed.
To correspond with a teacher or counselor via email, log into Skyward Family Access (Login screen opens in a new window) and use the instructions below:
If you do not have Skyward Family Access login credentials or need assistance with your account, please visit the District website's Skyward Family Access page (Opens in new window).
To contact a teacher or counselor by telephone, contact the campus main office at 806-326-4900.
The Amarillo Independent School District does not discriminate on the basis of race, color, religion, age, gender, disability, national origin, military status, genetic information, or any other basis prohibited by law.
Website Accessibility


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Bunker's Defense Paves Way To 5th Straight
With the score tied at 14 at halftime, Bunker Hill needed to make something happen against East Burke.
It did exactly that.
The Bears scored on the opening drive of the second half Friday and forced a fumble on the ensuing kickoff to seize control of their conference opener. The Bears scored five touchdowns in the second half en route to a 47-14 win at home Friday over the Cavaliers. Its the first time since 1980 the Bears started a season 5-0.
"This community has been so hungry and needed this," said Bunker Hill coach Travis Conner. "You can tell. You can see it in the stands. Everyone is excited about what is going on at Bunker Hill."
The Bears' defense and special teams stepped up their play in the second half. The defense limited the Cavaliers to 73 yards on offense, and it sealed the win with a late turnover. East Burke quarterback Matt Childers was under pressure and threw an interception to Bunker Hill's Nick Isenhour, who returned it 45 yards for a touchdown and gave Bunker Hill a 41-14 lead.
"I just looked at the end zone and had my eyes on getting there," Isenhour said. "The defense played with more intensity, played more as a team, and we didn't make stupid mistakes."
East Burke fullback Robbie McGee, who had a team-high 112 yards rushing, had only 19 in the second half. Conner said his team moved personnel around on defense to prevent the Cavaliers from running off-tackle with success.
The special teams put Bunker Hill on a roll forcing a fumble at the East Burke 23 on a kickoff return with more than 9 minutes left in the third quarter. That play set up a 3-yard touchdown run by running back Reggie Davis.
"You can't give a team that talented and that good a short field," East Burke coach Jim Ruark said. "They are going to capitalize on it and continue to capitalize on it."
Davis led the Bears' offense in the second half. The junior scored three straight touchdowns in the third quarter and finished the half with 95 yards rushing on 10 carries. His first touchdown put Bunker Hill up 21-14, his second 28-14, and his third 34-14 after a missed extra point.
Davis had a team-high 139 yards on 20 carries and three touchdowns — two runs from 3 yards out and his final score came on a 39-yard run.
The Bears had two players, other than Davis, break the 100-yard barrier. Davontaye Wilson ran for 118 yards on eight carries, and Justin Lynch had 103 yards on 12 carries.
Wilson scored his only touchdown in the first quarter on a 29-yard run up the left side and gave the Bears a 7-0 lead. East Burke countered with a 2-yard touchdown run by Marcus Setzer and trailed 7-6. Will Garrett put Bunker Hill up by eight points with a 1-yard scoring run, and McGee scored the Cavaliers' final touchdown on a 3-yard run. East Burke's Childers tied the game with a 2-point conversion.
Childers finished the game 5-of-10 passing for 54 yards and an interception. Bunker Hill quarterback Joe Litton was 1 of 3 for 18 yards.
The Bears play at South Iredell next week, and the Cavaliers play at home against Draughn.


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Pella city government offices will close on Tuesday for the New Year's Day holiday. The Pella City Council meeting, normally held on the first Tuesday of the month, has been moved to Wednesday in observance of the holiday. The Pella Public Library will close at 5pm on Monday and will remain closed on Tuesday. Leighton State Bank will close at 4pm Monday, and Marion County Bank will close at 2pm. All city offices and the library will reopen with normal hours on Wednesday.
In Knoxville, government offices will remain open for normal business hours during New Year's Eve. That includes Knoxville City Hall, and County offices, and the Clerk of Court Office as well. The Knoxville Public Library will be closing at 3pm on Monday. The Knoxville Recreation Center will be closing at 5pm. Iowa State Savings Bank and Wells Fargo in Knoxville will remain open for regular hours, but Valley Bank will close at 2pm. All those locations will remain closed on Tuesday.


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WASHINGTON (Reuters) - Senate Majority Leader Harry Reid said on Tuesday that an alternative debt limit and government funding plan promoted by conservative Republicans in the House of Representatives could not win approval in the Democratic-controlled Senate.
Reid said the plan, which was discussed at a House Republican meeting on Tuesdays morning, was "an extreme piece of legislation and it's nothing more than a blatant attack on bipartisanship."
Earlier, House Speaker John Boehner said no decisions had been made to bring the House plan up for a vote. The proposal would track several key parameters of an emerging deal that Reid is negotiating with Senate Republican leader Mitch McConnell but it would require some concessions on "Obamacare" health reforms and add some other restrictions on funding and borrowing.
(Reporting By David Lawder; Editing by Bill Trott)


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Downtown Manchester sidewalk project near
September 18. 2013 9:45PM
MANCHESTER — Downtown sidewalks will get a $380,000 facelift this fall, with much of the sidewalk brickwork dug up and replaced with a combination of new brick and concrete, city officials said.
Lyman Construction is expected to start work on the project next week and complete it by mid-November.
Brick sidewalks will be replaced on the east side of Elm Street between Merrimack and Bridge streets, according to the Manchester Department of Public Works. Brick will be replaced on the west side of Elm Street between Stark and Mechanic streets.
The city plans to work with downtown merchants to allow them to stay open and to maintain customer access during the reconstruction project.


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Introducing our new 3000K JDM Yellow 9005 LED bulbs for that beautiful color you've been looking for.
These 9005 LED bulbs will fit most Acura, Honda, Lexus, Toyota for Daytime Running Lights and will also fit H10, 9140 and 9145 housings for most American vehicles fog lights.
These super bright LED bulbs have 68 pieces SMD LED bulbs and will not only give you a 360 degree shine but also a price lower than the cost of HID bulbs.
The universal fit hyper-flux bulb will replace 9005 9140 9145 and H10 bulb sizes and can act as fog lights or daytime running lights.
To see if your bulb size fits visit our LED fitment guide.
Here are a few product pictures of the 68-SMD 9005 LED bulbs for daytime running lights or fog lights.
For installation guides on this product you can view our DIY Guide or contact us.
Also to view other product pictures we have a Gallery section, courtesy of our customers.
For all your LED lighting and HID lighting needs for your car, please visit www.iJDMTOY.com.


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Call Us
(877) 462-6700
(760) 208-6500
Don't want to call?
Service Questions
- Overview
- Submersible and Self Priming
- Dredges solids up to 4 inches in size
- Removes sand, clay and mud from work structures
- 800 gpm (3,028 lpm) discharge
- Easy volute inspection and clean out
- Can run dry without damage
- 4 in. discharge
- Steel volute, cast iron impeller & polyethylene wear plates
- CE Certified
- Capacity: 4 in. NPT with 4 in. Camlock
- Performance: 800 gpm / 3,028 lpm
- Flow Range: 7-10 gpm / 26-38 lpm
- Working Pressure: 2000 psi / 140 bar
- Full Relief Setting: 2250 psi / 155 bar
- Weight: 63 lbs / 281/2 kg
- Length: 18 in. / 45.7 cm
- Width: 19 in. / 48.3 cm
- Hydraulic Ports: 10 SAE Pressure / 12 SAE Return
- Connection: 1/2 in. NPT
- Couplers: Yes
- Hose Whips: No
- Description
The Stanley TP08 Heavy Duty Trash Pump is used for dewatering, dredging, cleaning and as a effective bilge pump. The gear motor is direct drive to the cast iron impeller with easy access for clean out of the fabricated steel volute.
The Stanley TP08 Heavy Duty Trash Pump has been designed to get the most from an HTMA Type II hydraulic circuit. Using only 9 gpm/34 lpm of hydraulic flow, the TP08 will pump over 800 gpm/3,028 lpm at a 10 ft/2.54 m head. The free-flow impeller and 4 in./ 100 mm inlet and outlet combine to make the TP08 one of the most efficient pumps in the business.
Weighing only 59 lbs/27 kg and with its convenient handle, the Stanley TP08 Heavy Duty Trash Pump can easily be handled by one operator. The Stanley TP08 Heavy Duty Trash Pump and the Stanley HP1 Compact Power Unit make a powerful, portable team for high volume de-watering and trash pump applications.
The heavy-duty construction of the Stanley TP08 Heavy Duty Trash Pump features a fabricated, all steel volute and abrasion resistant cast iron impeller. The volute uses replaceable UHMW polyethylene wear plates to reduce wear and extend pump life. The heavy-duty Stanley HYREVZ™ hydraulic motor is self-lubricating.
Routine maintenance for the Stanley TP08 Heavy Duty Trash Pump is easy. The top cover is attached to the volute with six wing nuts so cleaning and inspection can be accomplished in just a few minutes.
Note: In an effort to improve portability and ease of use, modifications have been made to all TP03 and TP08 model trash pumps. For both pumps a quick link clip (p/n 73577) and carrying handle (p/n 73576) were added and connected to the eyelet located on the top plate. The rounded handle allows for increased comfort while carrying when compared to the previous square handle. With the clip feature, the handle can be removed to allow for large crane hooks to attach to the eyelet. In addition, the color of the TP03 urethane bowl has been changed from black to yellow. This change was made to increase pump visibility while operating in murkier substances or liquids.
- Videos
Additional Information
Search Weight 70 Brand Stanley Tools Managed FEATURED PRODUCT GSA No DOD No Clearance Item No Video No
Product FAQ's
What is the maximum RPM of the TP08 pump?The TP08 is a 7 - 9 GPM tool. The RPM's listed below were tested with no load on the tool. 7 GPM = 248 RPM 8 GPM = 284 RPM 9 GPM = 319 RMP
ATTACHMENTS(Size: 1.6 MB)
Customers Who Bought This Item Also Bought
Stanley Tools 22546 Seal Kit for Stanley Hydraulic TP08 Heavy Duty Trash Pump
List Price: $63.80$56.49


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System crash briefly grounds Qantas boarding passes
Mile-high pilot romp doesn't help rep, either
In just another workday in the perpetual crisis-management of Qantas PR, a system crash at Sydney airport had check-in staff issuing handwritten boarding passes.
It's yet more bad publicity for an airline that early in November grounded its entire fleet to teach a lesson to unions; then last week nominated itself for "world's worst social media campaign" by inviting Twitter users to relate their "Qantas luxury" experience, creating a veritable Tweet-storm of public abuse.
Today's unexplained outage, which affected Qantas check-ins around the country, lasted around two hours, from 6.40am to shortly before 8am, during the morning business traveller peak. However, since the problem only affected printing rather than the ability to process passengers, the airline told the Sydney Morning Herald that the problem caused only "minor delays".
The Herald says that although Qantas asserted that overseas airports weren't affected, passengers in Auckland in New Zealand were also receiving handwritten boarding passes.
The embattled airline's reputation is also suffering one of the worst embarrassments possible, with Murdoch's Herald Sun airing passenger complaints that a pilot had a "steamy interaction" with a passenger on a long-haul flight between London and Australia.
The newspaper said the pilot was "not in uniform at the time of the incident," which may be regarded as redundant if the pair joined the mile-high club on the flight. ®
Update: Qantas has stated on Twitter that the outage was caused by upstream IT systems provider Amadeus, and that it affected all Amadeus customers worldwide. ®


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You have not viewed any products recently.
Expressing your feelings should always be this easy. Let our beautiful arrangement send the right message, with its stunning fresh pink blooms, including roses, lilies, carnations and more, hand-arranged by our florists inside a classic vase. With sophistication and style, it will have them smiling no matter what the occasion.
Vase measures 11"H. Large arrangement measures approximately 18"H x 11.5"L. Medium arrangement measures approximately 17.5"H x 11"L. Small arrangement measures approximately 17"H x 10.5"L. Our florists hand-design each arrangement, so colors, varieties, and container may vary due to local availability. Lilies may arrive in bud form and will open to full beauty over the next 2-3 days.
Order by 2:00 PM CST for same day pickup or delivery!
* Fee charged in addition to the Standard Delivery Fee
Enter full name. We'll ask for delivery information at checkout.
EXCLUSIVE Unleash your romantic side -- send your one-and-only our passionate puppy-shaped oversized Mylar balloon. Paired with an assortment of "I Love You" balloons, it's a big bundle of love that's sure to leave them walking on air.
Large bundle includes 6 assorted balloons. Small bundle includes 4 assorted balloons. Arrangements measure approximately 29"H x 32"L each. Balloon designs may vary based on local availability.
Box of Assorted Chocolates.
Add a cute plush from our plush selection. Selected plush will vary.


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AARP president shares trends in aging with students
The way society views aging is changing, and those working with this population in the future must be aware of these changes.
Rob Romasco, president of the American Association of Retired Persons based in Washington, D.C., gave students in the Family Interaction and Family Resource Management classes an insight into trends in aging and challenges on the horizon for the industry as he visited campus April 3.
"You are going to live in a world that is radically different than the world your parents or grandparents have lived in," said Romasco. "One generation helps the next generation. It's important to view people as a continuum, not as an old person but as a person who grows old."
Romasco noted that students in these classes are among the first generation in recent history who can "reasonably expect to live to 100 years and beyond."
As a result, the mindset of how to best serve the aging population is changing. The fact that the average life expectancy is getting longer than ever before also has an impact on economic and social organizations as they adjust their programs and services to meet the unique needs caused by this change.
"It is such a rare and exciting opportunity to have someone with Mr. Romasco's perspective and position on our campus, and to have him speak as openly and directly to students as he did is rare indeed," said John Conger, professor of Family and Consumer Sciences and chair of the department. "Comments from students have been very positive, and they found him extremely engaging. It is important that experts from the field reinforce what we are trying to teach in the classroom."
Younger generations have an opportunity to prepare for that stage in their lives, Romasco said, by saving, investing and getting to know older people, learning from their experiences and wisdom.
It is important for students to learn more about aging from experts such as Romasco, said Beverly Patnaik, academic director for Lipscomb's School of TransformAging.
"Having a chance to hear from experts such as Rob Romasco gives students an insight into a broad picture of issues affecting older adults," she said. "As he engaged the students by asking questions and telling stories, they related his anecdotes to their parents and grandparents. It is important for students to think about older adults as people and not just stereotypes as seen in the media. Mr. Romasco's spending an entire class period with students emphasized the value he and AARP puts on educating younger people about the upside of growing older."
AARP is a nonprofit, nonpartisan organization, with a membership of more than 37 million, whose mission is to strengthen communities, create awareness for and advocate for aging issues that matter most to families such as health care, employment security and retirement planning.
Romasco, an advisor to numerous organizations in business strategy, marketing and leadership development, is the current leader and chief national volunteer spokesperson of AARP, one of the largest member organizations in the world. He has also served as senior vice president of QVC Inc., the leading interactive retailer, where he was responsible for customer, distribution and new business development. In addition, he was chief marketing officer of CIGNA, CEO of JCPenny's insurance division and senior vice president of American Century Investments among other leadership positions.


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Get Government out of Our Bathrooms!
Get Government out of Our Bathrooms!
America's Founders never would have imagined that the government they created to protect freedom would one day be snooping even in the bathrooms of its citizens. Unfortunately, the many Americans forced to use new non-working but federally mandated toilets don't have to imagine.
In 1992, Congress passed the Energy Policy and Conservation Act, which outlawed the standard 3.5-gallon toilets used by most Americans and mandated new 1.6-gallon toilets. These toilets were supposed to work just as well and help save water.
But a growing number of new homeowners are discovering that the toilets often clog up and require several flushes to get the job done, raising doubts about whether they actually save water at all.
And relatively speaking, toilets don't use that much water. They account for 18 percent of household water use, and households represent just 13 percent of America's total water usage. This means that household toilets account for only two percent of all the water used in the United States.
Michigan Congressman Joe Knollenberg thinks it's time for government to butt out of our bathrooms. Congress should adopt his bill to repeal Washington's ridiculous toilet law and restore our freedom to flush.
For the Mackinac Center, this is Joseph Lehman.


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I truly feel blessed to be me.
I know many people curse the Gods because they have cancer. Click here to read my story if you want to get updated. I some how don't feel that way. In less than two weeks I've learned so many valuable lessons that I would have taken me 30 years to learn. I definitely would still be rushing to get to point B faster instead of enjoying the moment that I am in.
I also learned that love matters more than anything else. It doesn't matter how much money a person has because love is the most important part of my life. I knew this before, but it never really sunk in until my diagnosis.
[Read more…]


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The challenge of delivering smarter products
From cars and planes to medical electronics and consumer devices, developing the new generation of smarter products presents new challenges. Software is an ever-more important driver of innovation and differentiation and product developers face increasing complexity, competition and compliance constraints. Efficient delivery of smarter products forms part of Rational's vision for insight and product innovation , which requires more than traditional, siloed, mechanical design-centric approaches can offer.
From defining which products to build to architecting, designing and testing, you need collaborative, flexible solutions to manage the dependencies between the software, mechanical and electronic components.
IBM Rational can help you grow your business by providing capabilities tailored to your industry that enable you to design products and systems that are innovative yet dependable.
Contact IBM
Considering a purchase?
- Email IBM
Or call us at: 1-844-95-CLOUD1-844-95-CLOUD
Priority code: Cloud


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I have two eyes
one nose
two ears
two arms
two legs and four paws
Take me home
Condition: Brand New
Quantity: 1 PC
Facial Material: Super-soft Velour
Size: 63 inch(5.2foot)/ 160cm (length from ear to foot )
Color: Beige Brown
Notice: This item is a semi-finished product.Without stuffing inside, having zipper at the back
Every little girl's dream is a big teddy bear. Teddy bear is among the most popular gifts for children and are often given to adults to signify love, congratulations, or sympathy. He is cute. He will make you smile when the moment he shows up. People want to cheer up the person they care about when birthday comes, or Anniversary, Christmas, Graduation, Valentiens, and also mother's day. It will make the gift of a lifetime for someone very special in your life!
ADVICE for stuffing the bear(hope you remember how to make a Jackstraw)
1.Use some materials like cotton, cloths, soft fabrics etc. to stuff the paws of the feet. They will make the bear sit well firstly.
2.You can use sponges to stuff the legs and arms. They can be shaped as you want and has a good support when baby lie on the bear.
3.Don't forget to put more cotton in his belly to make sure a fat tummy. And his mouth and nose, make sure he has sweet teddy bear face.
4.It's not bad to fill his head with straws.
And I am sure you have a true heart when you do this for special someone.
All above are only advices. The cotton is always the best choice.


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For 50 years after the arrival of the railroad in 1896, one-third of Broward County was drained to support agriculture. Today, farming has nearly disappeared and 410 square miles have become a typical post-1945 suburban development of roads and one- and two-story buildings. High- and mid-rise development exists in downtown County locations along the Atlantic Beach. There are 1.8 million people that live in 31 municipalities, the Seminole Tribe area of Florida, and other unincorporated county areas. Today, the adult population is 48 percent White, 24 percent Black, 23 percent Hispanic and 5 percent other.
Environmentally, 810 square miles or 66 percent of the County is protected Everglades. The climate is subtropical (75.4F aver. temp.), with wet summers and falls, and dry springs and winters. Broward County is home to 4,097 restaurants, 56 golf courses, 14 museums, 123 bridges, 288 parks and 3,000 hours of annual sunshine.
Key Players in Broward County's Arts and Culture
Broward Cultural Division
The Broward Cultural Division is the government-designated local arts agency that provides services to artists and arts organizations for Broward County. It is advised by the Broward Cultural Council through mandates from the Broward County Commission. The Division's portfolio includes public information, public art and design program, workshops and financial assistance.
Cultural Quarterly fine arts online magazine provides in-depth articles on the local, cultural scene, featuring profiles of exceptional artists and detailed listings of events and attractions. The Division's website www.broward.org/arts, offers visitors a complete tour of more than 200 Public Art and Design projects, a searchable Cultural Directory; an arts education directory, a calendar of events database, a site to help cultural organizations manage county grants, cultural news, information and much more.
Cultural Organizations
Broward County's cultural organizations make up the backbone of the art and culture industry. There are more than 550 not-for-profit cultural organizations eligible for government grants, Cultural Division support, and the support and financing of private and business partnerships and enterprises. There are more than 10,000 artists and 4,141 arts-related businesses that employ 18,629 employees in Broward County. (Americans for the Arts' 2007 Creative Industries Report)
This becomes clearer every day, and every year in Broward County, where there is a growing network of cultural organizations, government and private partnership enterprise, and a diversity of multicultural arts and culture business endeavors, that are leading the way toward the new creative information economy. It is the statistics and growth percentages that tell the tale. The increase in tourism is heralded by a boost in hotel room stays and the steady increase in footprints through the Fort Lauderdale-Hollywood International Airport. Also, an array of national and international performing arts showcases, theaters, visual arts venues, music and artists are blooming as a result of dynamic infrastructure and creative enterprise.
Arts and Economic Prosperity III released by Americans for the Arts in June 2007 is the third study of its kind for the nonprofit arts and culture industry. It reports the economic impact of this industry on the nation's economy, and includes results from 156 communities (116 cities and counties, 35 multi-county regions, and five statewide studies). Data was collected from 6,080 nonprofit arts and culture organizations and 94,478 of their attendees across all 50 states and the District of Columbia.
Nationally, spending by arts groups and their patrons grew by 24 percent from 2000 to 2005 and the nonprofit arts sector generated $166 billion annually in total US economic activity.
Visitors Spend More
Non-local arts and culture event attendees spent an average of 67 percent more than local attendees per person.
Broward County's nonprofit sector generated $153.9 million annually in local economic activity, a number that is comprised of $66.65 million in spending by nonprofit organizations and $87.32 million in event-related spending by audiences.
The total number supports 4,258 full-time-equivalent jobs, generates $84.56 millions in household income to local residents, and delivers $14.64 million in local and state government revenue.
Participants in the 2006 Survey
All Florida Youth Orchestra
Ars Flores Symphony Orchestra
Art and Culture Center of Hollywood
Arts Ballet Theatre of Florida
ArtServe, Inc.
Bonnet House Museums and Gardens
Broward Art Guild
Broward County Film Society
City of Coconut Creek
City of Miramar Cultural
City of Pembroke Pines –
Fletcher Arts Center
Concert Association of Florida
Coral Springs Chinese
Culture Association
Curtain Call Playhouse
Fantasy Theatre Factory
Florida Atlantic University –
School for the Arts
Florida's Singing Sons Boychoir
Fort Lauderdale Children's Theatre
Fort Lauderdale Historical Society
Friend's of the Broward
County Library
Gold Coast Jazz Society
Gold Coast Opera
Inside Out Theatre Company
Master Chorale of South Florida
Maximum Dance Company
DBA Ballet Gamonet
Miami City Ballet
Museum of Art|Fort Lauderdale
Old Davie School Historical Museum
Performing Arts Center
Authority of Broward
Riverwalk Fort Lauderdale Trust
School Board of Broward County, FL
South Florida Choral Arts
South Florida JAZZ
South Florida Lambda Chorale
Stranahan House
Symphony of the Americas
The Opera Guild of Fort Lauderdale
Theatre League of South Florida
TranZenDance Dance Productions
Young At Art Children's Museum
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By Frederic Delavier and Michael GundillISBN: 978-1-4504-1399-2Binding: PaperbackPages: Approx. 144Price: $21.95Available: October 2011
Two signs it's time to change your workout program
CHAMPAIGN, IL—Stalled results during abdominal workouts leave many wondering why their routine failed. According to Frédéric Delavier, coauthor of the upcoming Delavier's Core Training Anatomy (Human Kinetics, October 2011), the same workout every day may reap rewards for a short period, but continued success requires modifying abdominal workouts to keep muscles challenged. "There is no set rule for how often you should modify your workout program. As long as your workouts are giving you regular results, why change them?" Delavier says. "But, there will always come a time when you will feel the need to make changes."
According to Delavier, there are two obvious ways of knowing when a workout program needs to be revamped.
The first type is great boredom and a complete lack of interest in abdominal work resulting from the monotony of overtraining. "When you first start working out, you feel like exercising every day to see results quickly," Delavier says. "But this excess enthusiasm can cause you to lose strength rather than gain it—a sign of overtraining." He advises reducing the quantity of training and starting a new workout program.
The second type of boredom involves a lack of interest in a particular exercise. "This is a sign that you have burned out the specific neuromuscular pathway for that exercise," Delavier explains. "You have to replace that exercise, but you may not need to make any other changes."
Delavier also stresses the importance of rest in a training regimen. "Muscle growth occurs only during the rest phase between workouts and not during the actual workout," Delavier says. "So it is just as important to know when to rest as it is to know when to exercise. If you aren't making progress, then you aren't getting enough rest."
Delavier's Core Training Anatomy is a comprehensive guide for strengthening and toning the midsection. It includes 362 full-color photos of over 100 exercises and 60 sample programs, including those for strength and athletic performance.
For more information, see Delavier's Core Training Anatomy.
Frédéric Delavier is a gifted artist with an exceptional knowledge of human anatomy. He studied morphology and anatomy for five years at the prestigious École des Beaux-Arts in Paris and studied dissection for three years at the Paris Faculté de Médecine.
The former editor in chief of the French magazine PowerMag, Delavier is currently a journalist for the French magazine Le Monde du Muscle and a contributor to several other muscle publications, including Men's Health Germany. He is the author of the best-selling Strength Training Anatomy, Women's Strength Training Anatomy, The Strength Training Anatomy Workout, and Delavier's Stretching Anatomy.
Delavier won the French powerlifting title in 1988 and makes annual presentations on the sport applications of biomechanics at conferences in Switzerland. His teaching efforts have earned him the Grand Prix de Techniques et de Pédagogie Sportive. Delavier lives in Paris, France.
Michael Gundill has written 13 books on strength training, sport nutrition, and health, including coauthoring The Strength Training Anatomy Workout. His books have been translated into multiple languages, and he has written over 500 articles for bodybuilding and fitness magazines worldwide, including Iron Man and Dirty Dieting. In 1998 he won the Article of the Year Award at the Fourth Academy of Bodybuilding Fitness & Sports Awards in California.
Gundill started weightlifting in 1983 in order to improve his rowing performance. Most of his training years were spent completing specific lifting programs in his home. As he gained muscle and refined his program, he began to learn more about physiology, anatomy, and biomechanics and started studying those subjects in medical journals. Since 1995 he has been writing about his discoveries in various bodybuilding and fitness magazines all over the world.
20 Steps to Creating the Perfect Core Workout Program
Increase the Visibility of Your Abs
Basic Exercises to Sculpt Your Abs
Advanced Exercises and Techniques
Ab and Core Exercises Using Machines and Accessories
Workout Programs for Abdominal and Core Muscles
Facts taken from Delavier's Core Training Anatomy.
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Like the best Cameroonian FinTech companies competing for the African FinTech Awards as a part of the Finance Indaba at Sandton Convention Center Johannesburg next October 12, 2017. The best FinTech companies in their respective categories can win the prestigious African FinTech Award. Like them now! Support their endeavours to let the African continent prosper! Be part of the revolution to enhance African financial services and financial inclusion! So like them now and keep track of the developments of the most promising Cameroonian FinTech companies below.
Companies per country : Cameroon


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Birds are incredibly gorgeous beings. They soar high in the sky, oblivious to our envy and awe. However, in small numbers, they can be beautiful. The problem arises when they start to overwhelm your residential and commercial space. They can instantly become a nuisance which needs to be eliminated by hiring skilled bird removal and control service.
Emergency Bird Removal in Woodbridge Virginia – (540) 205-6985
Bird infestation is fairly prevalent in urban areas. It commonly affects commercial buildings and multi-family residential units. Birds can lead to various health risks. Additionally, they can become a nuisance to the people who work and reside in these places. Our professional exterminators will help you to move them out. The most common nuisance birds are pigeons, crows, sparrows, starlings, gulls and swallows. Pigeons are especially notorious for their pesky persistence within communities that are heavily populated. They thrive and survive in places where there is ample of food sources available. Among all the bird control services, pigeon removal service is the most commonly requested.
Bird Trapping and Bird Control in Woodbridge VA
When faced with an enormous bird infestation problem, it is advisable to call our professional bird control service instead of addressing the issue yourself. A significant thing to keep in mind before attempting to undertake bird removal and control all by yourself, is the law. It is illegal to kill specific species of birds unless you are legally hunting. The law pretty much varies for every state. Our experienced bird and wildlife control company will eliminate the nuisance creating birds out of your home or office in the best possible way. We take a holistic approach which includes bird prevention and removal resulting in minimal harm to the environment.
Call Our Bird Deterrent and Bird Removal Experts Right Away!
Although most people consider bird invasion more of an annoyance than harmful to the health, the truth is that birds can pose great health risks for humans. Ticks, fleas, mites etc, tend to thrive within the bird droppings and their nest. Bird infestation can also lead to contamination of air ducts while they are nesting. We use highly safe birds and wildlife removal methods. These include careful bird and nest removal, relocation of the bird and their nest, thorough feces removal, washing and decontaminating the feces area, air duct cleaning, property maintenance and bird exclusion. We also offer several bird deterrent units such as motion sensors, spikes, audio- visual deterrents etc. Call us for the best bird removal services today!
Bird Removal Services in nearby towns:


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Therapeutic Focus 2013: Oncology
As genetically targeted immunotherapies blaze a trail through mid- and late-stage clinical trials, the days of traditional chemotherapy in taming tumors may be numbered. Noah Pines on the race to market cancer drugs that harness the PD-1 pathway, other standouts in the oncology pipeline, plus what's already making waves in the market
The data are still early, but the investigational PD-1s appear to be the Next Big Thing in oncology. By training the body's immune system to repel cancer cells, they've smashed through previous durable response-rate ceilings—one reason why agents that harness this pathway stood out from other gene-based therapies presented at June's American Society of Clinical Oncology (ASCO) meeting.
The compounds, which have shown efficacy even against the most stubborn tumors, have analysts talking about a sea change in therapy. "If they pan out, [PD-1s] could fundamentally change how solid tumors are treated," said inThought analyst Dr. Marc Engelsgjard. "That is a big deal. It is not one discrete event, more of a momentum story for that class of therapeutics."
To see a chart of the Top 50 Chemotherapy and Targeted Cancer Products, 2012, click here.
The hoopla over PD-1s highlights the revolution in oncology. At press time, eight of the 14 new drugs approved by the FDA this year were cancer medicines. The latest was July's approval of Boehringer Ingelheim's Gilotrif (afatinib) for people with non-small cell lung cancer (NSCLC) whose tumors express specific types of gene mutations, as detected by a Qiagen diagnostic test.
Along with other cancer drugs, those paired with companion tests that can detect a mutation—so-called targeted treatments—lifted the overall oncology market by 7.3% last year to $25.6 billion, according to figures from IMS Health.
Drug makers are increasingly personalizing their NSCLC cancer treatments. BI's Gilotrif targets the EGFR mutation, much like Roche's Tarceva, approved for use in the same subset two months prior. Pfizer's Xalkori hits the ALK mutation. And there are dozens more targeted NSCLC agents in development, says Sharon Karlsberg, an associate principal at ZS Associates, the implication being that "pathology and molecular testing of NSCLC tissue will become an essential part of any patient's overall treatment plan."
But targeted therapies have a big drawback: cancer cells can often build up resistance. Roche/Genentech's Zelboraf, for instance, targets the roughly 50% of melanoma patients whose tumors carry the BRAF gene mutation. In virtually all of these patients, the tumor starts to progress again in about five months.
Immunotherapies work differently. They retrain the body's immune system to kill cancer cells, potentially offering a durable effect and sustained response (possibly long-term survival). They have potential across multiple tumor types. Goldman Sachs, according to a July research note, estimates the market for PD-1/PD-L1 agents could reach $10-$15 billion, and that's just for NSCLC, renal and melanoma.
Those are the three tumors for which Bristol-Myers Squibb antibody nivolumab produced durable tumor response in heavily pretreated patients, an unprecedented feat. It's backed by a broad clinical development program. Phase I results were so promising that nivolumab is leapfrogging to Phase III across the three cancers.
With Yervoy, the first checkpoint immunotherapy approved for melanoma in 2011, and now possibly nivolumab, BMS "could have the first immunotherapy portfolio," says Dr. Sam Falsetti, medical director, Cambridge BioMarketing.
Merck has stolen some of BMS' thunder with its PD-1, lambrolizumab, which showed a potentially better overall response rate (ORR) in advanced melanoma and got FDA's "breakthrough therapy designation," which could pump the accelerator on its road to market.
"Merck seemed to be trailing by a year, but they may have the potential to close that gap," observes Engelsgjard. "They started a very large Phase II study last November…that could be a registration trial. If that is the case, then it might be a dead [heat] in terms of regulatory foot race." Not to be upstaged, oncology stalwart Genentech presented Phase I data from its investigational immunotherapy. Called MPDL3280A (also known or RG7446), a medicine which works slightly differently mechanistically. It's designed to make cancer cells more vulnerable to the body's immune system by interfering with the protein PD-L1.
It's thought that any immune-related adverse events can be managed by clinicians. And while studies initially have centered on later lines of treatment, immuno-oncology agents could be used in first-line settings, similar to the way chemotherapy has been used, notes Goldman Sachs, which forecasts the BMS and Merck PD-1s reaching $3.2 billion and $1 billion in sales, respectively, by 2018. (It doesn't include a forecast for Roche's PD-L1 agent.)
Versatility could add to their potential. "From the physician's viewpoint, the fact that these agents might be easy to combine with other targeted therapies to potentiate clinical efficacy is very lucrative," says Neesha Suvarna, a consultant with Kantar Health.
This year brought more momentum on the targeted-therapy front, including the February approval of Genentech's Kadcyla (T-DM1 or ado-trastuzumab emtansine), the first antibody-drug conjugate sanctioned by FDA for treating HER2-positive metastatic breast cancer.
And the agency is slated to decide this year whether the drug maker's breast cancer drug Perjeta can be used in the neoadjuvant (pre-surgey) setting for HER2-positive, early stage breast cancer—a first. GlaxoSmithKline's Tykerb is also being studied in this setting.
Also of interest is Genentech's anti-CD20 antibody conjugate GA101 (obinutuzumab), the so-called heir to Genentech's best-selling Rituxan. GA101 is designed to work with the body's own immune system to attack B cells that can cause common blood cancers.
The company recently submitted data to the FDA for newly diagnosed chronic lymphocytic leukemia (CLL), and the medicine was granted a priority review and breakthrough designation by the FDA. GA101 is also being studied in non-Hodgkin's lymphoma (NHL).
GA101 could help to extend Genentech's $7-billion Rituxan franchise, which soon will be subject to biosimilar competition. "This is a commercially important program for Genentech and Roche," opines inThought's Engelsgjard.
When asked to identify an in-line oncology "product of the year" for 2013, Engelsgjard points to Xtandi (enzalutamide), Astellas' prostate cancer drug that was developed with Medivation and approved in the US last September and in the EU in June. Xtandi has had a decent launch in the US with $57 million in Q4 2012 and $75 million in Q1 2013, a trajectory that mirrors J&J's Zytiga.
It's being studied in a Phase III study called PREVAIL which evaluates its role in chemotherapy-naïve prostate cancer patients and, if labeled such, puts it into more direct competition with Zytiga.
Among other strides being made: in hematology, Gilead reported results for idelalisib (GS-1101), its first-in-class agent for CLL. "In the hematology sections, idelalisib and other B-Cell receptor pathway drugs were mentioned in multiple [ASCO] presentations for CLL, iNHL and MCL," reports Abelson Taylor SVP Jay Carter. In a Phase II study of idelalisib + rituximab, the overall response rate was 97%, consisting of 19% complete responses and 78% partial responses.
As drug makers better understand the biology of cancer, the number of drugs the industry is putting forth to hunt tumors has proliferated. Yet, the amount of patients available for clinical trials hasn't kept pace.
Novel agents sport unique mechanisms of action, each designed to strike relevant targets—growth factors, growth receptor, components in signal transduction pathway, or a cell in the tumor lifecycle.
The abundance of clinical studies in these areas means increasing "competition" for a limited scope of subjects, says Alexander Zukiwski, MD, chief medical officer, Arno Therapeutics. R&D in these areas has generated "a larger number of clinical studies going after a limited patient population which is willing to participate," he says.
The patient-shortage challenge is shared by clinical research organizations—again, contrasted with R&D advancements. New trials are evaluating Bristol-Myers Squibb's Yervoy and anti-PD1 or PD ligand monoclonals, but there is a shortage of available patients. "In the US, for example, only 5%-10% of potentially eligible adult cancer patients are enrolled in clinical trials," says Denis Miller, MD (pictured), global therapeutic area leader, oncology-hematology within the CRO Parexel International, "largely because they are not informed about an open trial designed for them."
Many still harbor a mistrust or fear of "experimental" therapy, says Miller, citing additional reasons such as the amount of time and money needed by clinicians to attract their patients to a new clinical trial, fund the research projects at a level that will be attractive to clinical investigators and remain compliant with federal regulations.
Harish Dave, MD, MBA, VP of medical and scientific services at Quintiles, adds an important oncology drug-development challenge: tissue sampling. Researchers collect tissue to determine, for instance, whether the patient has a target mutation. "[Tissue samples] allow for identification of the patient subset that is most appropriate for a therapy," explains Dave. So the initial sample is relevant, but in instances where patients have metastatic disease and have failed multiple therapies, "it is important to look at the tumor that has spread and determine what mutations/features it has," adds Dave.
This can result in a patient-profiling hang-up: when patients' gene expression profiles and mutations change during treatment and disease recurrence or metastasis. Targeted therapy directed against that gene mutation expressed in the original tumor may no longer be effective.
CROs call this instability of gene expression. And it can be seen in programs involving companion diagnostics, or biomarker programs, which need to be developed in parallel with targeted compounds. These diagnostics are what permit personalized cancer therapy.
"For example," says Miller, "the HER2 status may change from positive to negative in 10%-15% of patients with breast cancer. Thus, an agent directed against overexpression of HER2 may no longer be active."


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It's worth your time as a runner to work on improving your overall athleticism.
The chiseled core of a swimmer. The explosive power of a basketball player. The supple flexibility of a gymnast. The nimble agility of a lacrosse player. While running is typically thought of as a solely linear motion, runners can really do themselves a lot of good when they shift focus from only moving forward in a straight line to working on improving their overall athleticism.
"Running is mostly thought of as a cardiovascular sport but it's the muscles that do the work and the brain that ultimately controls everything," explains coach Steve Magness, who most recently worked alongside Alberto Salazar at the Nike Oregon Project. "By becoming more athletic you gain multiple benefits. First, you become more injury-resistant because your body learns how to move in multiple planes of direction instead of simply knowing how to run in a straight line. Secondly, your nervous system is really challenged so that it adapts and creates a more efficient connection from the brain to the muscle."


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Walgreens Charlottesville
Address & Contacts
(434) 964-1082
22911 Charlottesville
Opening Times
|07:00am - 10:00pm
|07:00am - 10:00pm
|07:00am - 10:00pm
|07:00am - 10:00pm
|07:00am - 10:00pm
|07:00am - 10:00pm
|07:00am - 10:00pm
Warning, Stores-Locator.com is a participative website where everyone can indicate the opening hours, please let us know if you notice any mistake.
Walgreens Charlottesville is usually open Sunday.
These times do not include public holidays. To see if your store is open these days, contact them.
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Having started out as a simple drug store in small space that only measured 50 by 20 feet, the drugstore rapidly grew over the decades to become one of the most respectable American pharmacies. In truth, Walgreen has become the standard of measure for all good pharmacies. This story began way back in 1901 in a town going by the… more about Walgreens
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Stella And Dot: From jewelry to apparelThe successful jewelry brand is planning a major evolution for this Spring: some items of clothing will be introduced in a few weeks.
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