text:
digital media
video • motion graphics • 3D animation
Digital media is at the heart of who we are. We produce motion graphics, interactive infographics and applications, and compelling video and animations.
The design team at ruef has the experience and expertise to create stunning work in traditional physical formats. We can make your business shine, however, when we use our expertise to create digital media that will truly make your company stand out.
Even the most intricate processes and products can be broken down into the simplest visuals using video, animation and motion graphics. Imagine the complexities of your company, the day-to-day challenges and the tales of success you have brought to your customers – all summed up in an engaging video or animation. Imagine being able to replace boxes of sales sheets and expensive brochures with an iPad or microsite that displays a 3D landscape or interactive application. Digital media allows you to communicate with your customers, employees and partners in ways that previously were not possible.
Video and motion graphics have tremendous potential to instill emotion and affect business decisions (and not to mention your company will look rad).


text:
Note: Images may show upgrades
Be the first to review this product
Hoyer deluxe stand-aid sling is an easy fit sling suitable for standing and transporting. Stand-aid sling allows excellent access for toileting and is easy to fit, providing quick and effective transfers.
Availability: In stock
Regular Price:
Special Price
Hoyer deluxe stand-aid sling is an easy fit general purpose sling giving full support to the user. Stand-aid sling will not suit double amputees or lifting from a horizontal position. Hoyer stand-aid sling is suitable for those having a greater degree of weight bearing ability.Deluxe stand-aid sling has weight capacity up to 440 lbs.
Sling use Disclaimer: Please note that we recommend only to use the recommended brand slings with your Patient lifts, we do not guarantee compatibility of other sling brands with your lift model.
"Hygiene" items are non-returnable for health reasons
Hoyer slings guide
Hoyer slings selection guide
The manufacturer warrants slings to be free from defects in materials and workmanship after purchase by the original consumer/owner as below:
Please call us for specific details
* Required Fields
Only registered users can write reviews. Please, log in or register
87 Danbury Road, Unit 1 New Milford, CT 06776
Tel: (866) 563-6812 Mon-Fri, 8.30am to 5pm EST Fax: (860) 838-4671
App for iOS
App for Android
© 2017 Medicaleshop.com. All Rights Reserved.

subset: commoncrawl


text:
Homecoming & Reunion Weekend 2017!
Save the Dates!
Scroll Down For More Details!
The Homecoming experience for our alumni will be greatly enhanced this year by combining Homecoming for all graduates with Reunions for specific classes in a weekend of special events. We would like to highlight all classes on five year increments; classes of '92, '97, '02, '07 and '12. The schedule will be balanced between school events and those activities that classes schedule for themselves.
All-Alumni Dinner
(Ticket Deadline Extended)
Join us for a dinner at the new Coca Cola facility for an evening celebrating all of our alumni as well as faculty and former faculty members. We welcome alumni parents, too!
Classes on reunion years will be recognized and you will be updated on Grace Academy's goals and direction. Registration is automatic when you buy tickets online, the only place where tickets are available. The deadline for ticket purchase has been extended to Thursday, September 28 at noon. Please note, too, that child care is not available for this event.
Alumni Golf Outing
Not a fundraiser...just a fun time together. Hit the fairways with friends and classmates for a relaxing morning. For more information and registration for the Alumni Golf Outing please contact Jason Smith at (423) 488-6429 or [email protected]. Directions to Brown Acres Golf Course may be found here.
Choir Reunion
Past members come join the choir in rehearsal for Friday Night's performance. Prepare to perform the National Anthem and the Alma Mater at homecoming, as well as singing some of your old favorites for fun with former classmates. MAIN AUDITORIUM 1:30 p.m.
Homecoming Activities
6:00 p.m. - Grace Fitness Center
Groundbreaking Ceremony
6:30 p.m. - Gates Open / Dinner Served
6:45 p.m. - Homecoming Court Presentation
7:30 p.m. - Kick-Off
Reunion Day
Reunions will be held by those Classes who have scheduled activities. Locations / times will be updated as they are made available to us. For further information contact the following:
Class of '12 - SOUTHSIDE SOCIAL
Friday Post Game
Bethany Cowart [email protected]
Class of '07 - CADENCE COFFEE
Saturday 6-9 p.m.Kyndall Blake Squires [email protected]
Class of '92 - MAPLE STREETBISCUIT
Saturday 10:30 a.m. Katherine Euler Fisher [email protected]
Class '89-'91 - TBA Amy Smith [email protected]


text:
Multilingual Fresh Graduate Seeking Employment (Taipei)
Dear All,
End of Protected content , I graduated from the University of St. Andrews achieving my MLitt in International Business & Strategy with distinction (postgraduate degree). I am currently living in Taipei and taking intensive lessons of Mandarin at the NTNU (since March Protected content . I am actively looking for a job in Taipei in the field of research and strategic analysis/consulting, or any role that would enable me to make good use of my language skills. However, I remain interested in any opportunity available.
Through two internships (6 months each), I have gained experience both in strategic consulting (PwC, Geneva) and in economic research (UBS Investment Bank, Zurich). I speak fluently French (mother tongue), German and English and have intermediate Spanish. I also had the chance to learn more about different cultures through my travels and stays abroad (1 year in Germany and 1 year in UK). I like to think of me as person who takes no as a challenge, not an answer. I believe that all those capacities make me highly employable in many sectors.
I thank you in advance for your kind consideration.
Please, do not hesitate to contact me ( Protected content ) if you have any question or wish to view my CV and other supporting documents.
Best Regards
Damien Kaeser


text:
Medical Definition of Planum orbitale
1. The orbital surface of the maxilla, lying perpendicular to the orbitomeatal plane at the orbitale. Synonym: planum orbitale. (05 Mar 2000)
Planum Orbitale Pictures
Click the following link to bring up a new window with an automated collection of images related to the term: Planum Orbitale Images


text:
Report, Available water supply of the Las Vegas ground-water basin Nevada, 1965
- Title
- Report, Available water supply of the Las Vegas ground-water basin Nevada, 1965
- Individual Creator
- Description
- Report on the available water in the Las Vegas area
- Abstract
- The Las Vegas ground-water basin as described in this report includes the southern part of Indian Spring Valley, Three Lakes Valley, the northern half of Ivanpah Valley, and Las Vegas Valley. These valleys in part are inferred to form a hydrologic unit that includes an area of about 3,000 square miles in the southern part of Clark County, Nev. The valleys forming the Las Vegas ground-water basin are broad structural depressions surrounded by mountains. The climate of the region is arid, and precipitation in the basin lowlands rarely exceeds 5 inches per year. Drainage is interior except for occasional Hood runoff and waste from the industrial plants at Henderson; the occasional flood runoff and waste flow through the Las Vegas Wash to Lake Mead. The mountain ranges are composed of indurated rocks that impede the movement of ground water from the basin and form the boundary of the ground-water reservoir. The valley fill that forms the principal ground-water reservoir is composed of a thick sequence ranging from Miocene (?) through Recent in age. Most of the ground water is in a large leaky artesian system comprising four principal zones of aquifers—the deep, middle, and shallow zones of artesian aquifers and the near-surface zone of water-table aquifers. To facilitate quantitative analyses of recharge, discharge, and yield, the aquifers have been divided arbitrarily into an artesian system, which includes the three principal artesian aquifers, and the near-surface water-table system. Natural recharge to the artesian system is from precipitation in the mountains within the drainage area of the basin. As ground water moves from areas of recharge toward areas of discharge in the lower parts of Las Vegas Valley, it becomes confined between relatively impermeable beds. Nearly impervious barriers caused by faulting of the valley fill impede the lateral movement of the ground water. Artesian pressure causes the water to leak upward along the faults into shallow aquifers. The average annual natural recharge to the Las Vegas artesian system was estimated by the following methods: (1) Estimation of consumptive use by phreatophytes under natural conditions prior to ground-water development; (2) estimation of ground-water underflow to the Las Vegas area during a period of near-stability in the ground-water reservoir; and (3) study of the relationship between precipitation and recharge during periods of equilibrium in the ground-water reservoir. Estimates of the natural recharge based on these methods suggest that the average annual natural recharge to the basin is on the order of 25,000 acre-feet. The total draft on the artesian aquifers in 1955 was approximately 48,000 acre-feet, of which about 42,000 acre-feet was from wells and springs and about 6,000 acre-feet was from upward leakage. Therefore, overdraft on the artesian reservoir in 1955 was about 23,000 acre-feet. Recharge to the near-surface reservoir in 1955 was derived from upward leakage from the underlying artesian aquifers and by infiltration of waste water. The total estimated recharge to the near-surface reservoir in 1955 was about 25,000 acre-feet. The draft on the near-surface reservoir in 1955 was about 25,000 acre-feet, of which about 24,000 acre-feet was discharged by phreatophytes and about 1,000 acre-feet was discharged by wells. During this study, the near-surface reservoir was in a state of approximate dynamic equilibrium. The above data indicate that the overdraft on the entire Las Vegas ground-water basin in 1955 was approximately equal to the overdraft on the artesian aquifers���that is, about 23,000 acre-feet. As the artesian heads continue to decline in Las Vegas Valley, the quantity of ground water lost through upward leakage and subsequent transpiration will decrease. Conditions of optimum development of the artesian system will be achieved when the artesian heads have been lowered to about 50 feet below land surface, because most of the upward leakage that is currently discharged by phreatophytes will have been eliminated. At the present rate of decline of the artesian head and with the present distribution and amount of withdrawals, the artesian head will be lowered sufficiently to prevent most natural discharge in the Las Vegas area in about 40 years and in the Paradise Valley area in about 75 years. The maximum sustained yield that can be developed from the artesian aquifers when the artesian head has been lowered below the root zone of phreatophytes will be limited to the approximate average annual natural recharge to the artesian system plus the amount of nonconsumptively used ground water and imported water which becomes available for reuse through downward leakage or artificial recharge. The accumulated annual discharge from the Las Vegas artesian aquifers has exceeded the accumulated recharge since the development of the first successful well in 1906, and as a result the artesian pressure has declined almost uninterruptedly from year to year since that time. The artesian head in selected observation wells in the vicinity of Las Vegas and Paradise Valley declined about 30 feet between 1941 and 1956. During this time the approximate cumulative overdraft amounted to about 300,000 acre-feet. The amount of overdraft per foot of lowering of artesian head within the area of approximately 40 square miles represented by the observation wells during this period was about 10,000 acre-feet. The chemical quality of the ground water in Las Vegas Valley is, in general, better in the northern than in the southern part of the valley. In the northern part of the valley, water from the shallow and middle zones of aquifers is of better quality than water in the deep zone of aquifers. As the ground water migrates southward into the Paradise Valley and the Whitney-Pittman areas, the water in the middle and shallow zones becomes more mineralized than the water in the deep zone of aquifers. The lowering of artesian head in the Las Vegas area between 1935 and 1950 has caused about 180 millimeters of local land subsidence in the vicinity of the Bonanza Street underpass, where the sediments are predominantly clay and silt. In the western part of the valley, where the sediments are predominantly sand and gravel, subsidence during the same period of time was negligible.
- Identified Individuals
- Group Contributors
- Original Series
- Geological Survey Water-Supply Paper 1780
- Accession Number
- Original Collection
- Formatted Date
- 1965
- Alternative Date
- 1965
- Geographic Feature (Getty TGN)
- Local Geographic Feature
- City or Town (Getty TGN)
- County (Getty TGN)
- State (Getty TGN)
- Country (Getty TGN)
- Subject (FAST Topical & Geographic Headings)
- DC Type
- Genre (TGM)
- Local Genre
- Language
- Relations
- http://digitalcommons.library.unlv.edu/water_pubs/123
- Is Part of
- http://digital.library.unlv.edu/u?/dig,2
- Rights
- This material may be protected by copyright. Personal, including educational and academic, use of this material is without restriction but acknowledgement of the University of Nevada, Las Vegas, University Libraries is requested whether the use is oral, web or in print. Commercial use of any portion of this material requires permission from the University Libraries. For further information please contact Digital Collections: http://digital.library.unlv.edu/contact
- Format
- application/pdf
- Measurements
- 5.96 x 9.06 inches
- Digital Publisher
- University of Nevada, Las Vegas University Libraries
- Digital Collection
- Conversion Specifications
- Original material scanned on Zeutschel OS10000 TT using Omniscan 11 software
- Digital ID
- hln000822
- Access ID
- 828
Cite this Item
When linking to this object, please use the following URL:
CommentsSubscribe to recent comments
There are no comments yet. Be the first to comment below!


text:
Playing in the Rose Theatre or Rosebud Cinema
|Fri, 9/15 - Sun, 9/17
|All day!
The 17th edition of the Port Townsend Film Festival is shaping up to be one of the best. The stellar line-up of films is online now - www.ptfilmfest.com - so check it out.
With dozens of tremendous movies, they'll also be offering free outdoor flicks in the evenings on Taylor Street, featuring CHICKEN RUN, 20 FEET FROM STARDOM and THE PRINCESS BRIDE.
Don't delay, get your festival passes today!


text:
DSpace Repository
The use of neural networks to determine the long-term impact of demand side management
DSpace Home
Completed research projects
North-West University
View Item
The use of neural networks to determine the long-term impact of demand side management
Kaiser WH
Eskom, South Africa national electricity provider estimates that in the year 2006 South Africa will experience a capacity shortage. One way to address this problem is through the implementation of Demand-Side Management (DSM) in various sectors, ranging from the commercial to the industrial. For Eskom to succeed in their vision of implementing DSM, a tool has to be developed that can illustrate the long-term impact of various DSM options for a region. This tool could then be used to illustrate the various role players the advantages of implementing DSM. The purpose of this study was to test if Neural Networks (NN's) can be applied in the construction of an hourly baseline for a region. This baseline could then be used to illustrate the Long-term impact of various DSM options. In this study a technique was developed using hourly data to construct a baseline model for the calculation of the long-term impact of DSM. This technique was then tested and evaluated on a case study. To achieve this goal, an investigation was launched to determine which inputs have an influence on the energy use of a region. The different variables that influence the neural network topology were also investigated. This information was then used to develop a technique that models the energy use of the area. To determine accuracy of the simulated energy use, a verification procedure was developed based on an internationally accepted verification model, using data the NN did not "learn" on. Sufficient accurate results were obtained using the defined indices. Thus NN can be used to model the energy use of a region. The major disadvantage of this technique is that hourly data for the whole year was used to train the model on. The question arises into just how much information is needed to model the NN. Subsequently an investigation was launched to determine the minimum data set needed to model the energy use. It was found that a full factorial data set is the minimum set of data that a NN needs to train on. In choosing this data, a study has to be conducted on previous data to determine exactly when the best combination could be obtained. The results indicated that the data could not be minimised due to the configuration of input data. For this study, the months of the year were encoded. This aided the NN in learning the relationship between the various inputs and the energy use. It was found that this is a crucial step in aiding the NN. Thus the NN could not simulate accurate enough results without the encoded data. This results that the number of months cannot be minimised with the current technique used. The model then can be used to evaluate different DSM options by subtracting the hourly differences from the baseline. This information is then used to evaluate the options using various indices. The indices included monthly energy use, maximum demand, and the energy use during the various time of use periods, and the impact of greenhouse gasses. The concept was illustrated by an actual case study. The use of NN for modelling the baseline for the forecasting of the long-term impact of DSM is considerable faster than current techniques with a timesaving element of up to 90 %. The use of NN is thus a viable technique to model the baseline. The results indicate that NN can successfully be used for cases with a high diversity in the load, and with little or no knowledge of the underlying systems.

Show full item record
Files in this item
There are no files associated with this item.
This item appears in the following Collection(s)
Search DSpace
Search DSpace
This Collection
Advanced Search
All of DSpace
Communities & Collections
By Issue Date
This Collection
By Issue Date
My Account
Recent Submissions
South African Data Archive
Submitting Research Projects
Submitting NRF-funded ETDs
South African ETDs
Global ETDs Search
External Links
Social Networks
DSpace Software
copyright © 2002-2015
Theme by
Contact Us
Send Feedback


text:
Hello my friends. I am Caleb, the world's most interesting ego shooter protagonist. I don't usually indulge in false hipsterism, niche micromarket pandering, or sugary kids drinks, no, I can scarcely see past that ol' bottle of red 99 most of the time, but when I *do* indulge, I drink CalebCola!
Caleb'sCola; From the old world craftsmanship of the paint job on our 2009 Chevy delivery van, to our use of beyond -the-20-year-copyright-date-limit print art for ancient advertisements, you find Caleb'sCola to be the refreshment you need.
Stay bloody my friends.
Here...drink this!
Anything not gaming related goes here. Not sure where something should be posted? Post it in here.
Moderators: Slink, General Discussion Moderators
3 posts • Page 1 of 1
Re: Here...drink this!
LOL I was expecting some photoshopped pics. This is awesome.
I don't normally drink cola but when I do I drink Caleb's.
Stay bloody my friends.
- VGames
I don't normally drink cola but when I do I drink Caleb's.
Stay bloody my friends.
- VGames
- dosgamer000
- Acolyte
- Posts: 281
- Joined: Sun Aug 14, 2011 07:57 pm
- Location: Boggy Creek
Re: Here...drink this!
My life was completely and utterly changed after switching to Caleb's Kola. I felt like a whole new, dead man and my vigor at the slght burning men in brown robes was a neat surprise. Would definitely recommend wearing a cowboy hat and matching black trenchcoat while drinking.
Also, is it just me or does this taste like blood? Eh, I'm sure it's not.
Also, is it just me or does this taste like blood? Eh, I'm sure it's not.
3 posts • Page 1 of 1
Who is online
Users browsing this forum: No registered users and 1 guest


text:
Air Cleaner Assemblies
When changing the filter just isn't good enough anymore, it is time for the air cleaner assembly to be replaced. Or perhaps an aftermarket air cleaner is desired to improve engine performance. Air cleaners ensure that clean and sufficient air is getting into the engine. Air in the engine means more power, and in many cases better gas mileage. Fancy aftermarket air cleaners can be installed to significantly increase engine power. These are usually quite showy chrome pieces that stick out above the hood of the engine. The more air in the engine, the more torque and horsepower that is available. For regular drivers, the air cleaner assembly can stay under the hood, but can also significantly improve the power available. Keeping the assembly clean and in working order keeps a car running at top capability. Ensuring that filters are replaced regularly goes a long way in keeping performance up.


text:
In Fayette County, Kentucky, officials have reversed their decision to make the mascot of the new Frederick Douglass High School a stallion because of, well, sexism.
Fayette County Schools Superintendent Manny Caulk said in a statement, "Since the public announcement of the mascot Monday, we have received feedback from some community members who have concerns about the mascot and we want to assure our constituents that there was absolutely no intent to offend or upset anyone," according to WKYT.
Apparently the stallion being a breeding horse is just too patriarchal for some of the more liberal community members.
Advertisement - story continues below
In fact, a petition on Change.org was created to try to prevent the stallion from remaining the school mascot, and has apparently succeeded.
The stallions mascot is bad because it "is inappropriate and sexist when you consider the definition from 'YourDictionary' … 'The definition of a stallion is a male horse that has not been castrated, used for breeding, or is slang for a powerful and virile man who has lots of lovers,'" the petition read.
TRENDING: Hate: CNN Commentator Explodes Over Trump Supporter's Minority Son
"And from Wikipedia … 'because of their instincts as herd animals, they may be prone to aggressive behavior, particularly toward other stallions, and thus require careful management by knowledgeable handlers. However, with proper training and management, stallions are effective equine athletes at the highest levels of many disciplines,'" the petition continued.
Heaven forbid that a school have a mascot be aggressive.
Advertisement - story continues below
"What message does this send to our daughters and granddaughters? Our sons and grandsons?" the petition went on.
"We demand that the name be changed to something more gender-neutral and more indicative of Douglass' brilliant mind, successful career and vision for equality and to send a message to all students that they are respected and valued," the petition concluded.
Just another accommodation to the insanity that is trying to prevent anyone from becoming offended.
H/T EAGnews
Please share this on Facebook and Twitter and let us know what you think about this insane complaint!
What do you think of this petition? Scroll down to comment below.


text:
International Journal of Mathematics and Mathematical SciencesVolume 2003 (2003), Issue 7, Pages 451-459doi:10.1155/S0161171203110198
1Department of Mathematics, Indiana University, Bloomington, IN 47405-7106, USA2"T. Popoviciu" Institute of Numerical Analysis, P.O. Box 68-1, Cluj-Napoca 3400, Romania
Received 19 October 2001
Copyright © 2003 B. E. Rhoades and Stefan M. Soltuz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
Vision Consulting was setup in 2002 by the principal who worked for one of the largest international firms of accountants in the world (KPMG) gaining invaluable experience. Our clients range from an individual with a single residential property to major brands.
Vision Consulting provides an efficient, excellent quality service with a practical understanding of business issues...
Vision Consulting were appointed by Albannach Brands Plc to assist at a very challenging time...
Vision Consulting is a boutique firm of chartered accountants and registered auditors set up to service the business needs of our clients.
Our non corporate clients range from an individual with a single residential property to directors of major brands. Given our commitment to staff training and technology we are able to service our client needs no matter where they are based.
Places where our clients have been based include UK, Dubai, Bahrain, Monaco, Saudi Arabia, Hong Kong, continental Europe, South America, South Asia. Our Corporate clients are mostly based in the UK and in the SME sector.
They trade in a diverse range of areas including:
We have a passion for our work and each team member is carefully selected and trained to ensure our values are reflected in everything we do.
The bulk of our work is referred from existing clients since we focus on quality and attention to client needs.
Vision Consulting was set in 2002 by the principal who worked for one of the largest international firms of accountants in the world (KPMG) gaining invaluable experience.
We are registered with the Institute of Chartered Accountants in England and Wales (ICAEW), which is the oldest accountancy body in the UK. Over 80% of the Companies on the FTSE 100 have a member of the ICAEW on their board.
We are part of the HAT group which shows our commitment to maintaining the highest standards of work.
We have invested in our office, IT infrastructure and software systems so that we can continue to maintain a quality service.
Vision Consulting is one of only 2,100 organisations in the world that are recognised by the ICAEW to train Chartered Accountants.
We truly strive for excellence in all we do.


text:
I think that it's good for young women (and everyone else) to celebrate their beauty (and, when the time is ripe, sexuality) in authentic ways. But given the society we're living in, I believe that this requires resisting some powerful cultural norms. For teen girls, it might mean rejecting the idea that you need to prove that you're grown up by putting on an uncomfortable uniform of tight, short, low-cut dresses and high heels. For female yoga practitioners, it might mean countering the pre-packaged image of being serene, smiling, beautiful, bendy, thin, well-accessorized, and perfectly flawless.
|Photo courtesy of Sarit Photography
|Photo courtesy of Sarit Photography
This morning, I stumbled across a Tumblr of phenomenal yoga shots featuring Black women by Sabriya Simon Photography. I think that the one below is one of the best yoga photographs I've ever seen:
|Photo courtesy of Sabriya Simon Photography
|Photo courtesy of Sabriya Simon Photography
The following shot by the San Francisco-based photographer, Faern was part of the So Hum: Self Expression Through Yoga project that she did with Erica Rodefer. It's remained one of my favorite contemporary yoga images ever since I first saw it:
|Photo courtesy of FaernWorks Photography
Why strive to be a Barbie when being you is so much more creative, interesting, and authentically beautiful?


text:
"Or, to illustrate still further, the picture of a leaf would become the sign for the syllable 'leaf' wherever it might occur, and the picture of a bee would become the syllable 'be' the pictures together forming the word 'belief.' The picture of the bee would then cease to represent the insect and would represent only the syllable 'be,' and the picture of a leaf would no longer signify leaf or foliage; the pictures would have become purely phonetic symbols, expressing words as well as ideas, the next step in their evolution toward real writing."
The Alphabet and Elements of Lettering; Frederic W. Goudy (1918)
The Alphabet and Elements of Lettering; Frederic W. Goudy (1918)
Materials used: balsa wood, leaves, twigs, polymer clay, acrylics, polyester glass casting resin.
Making of >
Making of >
Thank You!


text:
The eosinophil is well recognized as a central effector cell in the inflamed asthmatic airway. Eosinophils release toxic basic proteins and lipid mediators such as cysteinyl-leukotrienes that cause bronchial epithelial damage and airflow obstruction. Eosinophil-selective cytokines and chemokine including interleukin (IL)-5, eotaxin and RANTES may represent targets for novel asthma therapies.
Related Journals of Eosinophilic Inflammation
Archives of inflammation, Immunogenetics: Open Access, Infectious Diseases & Therapy, Immunome Research, Immunome Research, Immunology, Immunology and Allergy Clinics of North America, Journal of Allergy and Asthma, Immunopharmacology and Immunotoxicology, Indian Journal of Allergy Asthma and Immunology
All Published work is licensed under a Creative Commons Attribution 4.0 International License
Copyright © 2018 All rights reserved. iMedPub LTD Last revised : August 20, 2018


text: EntertainmentCelebrity The funniest celebrity mugshots (ft. Lindsay Lohan, Amanda Bynes, Snooki — and more!) Photo 1 of 30Alexis Neiers, the star of an E! reality show and a convicted member of the "Bling Ring" celebrity burglary crew, was sentenced to a year in a Malibu drug treatment center after she was found with black tar heroin.HandoutPhoto 2 of 30Amanda Bynes was arrested after for DUI after her BMW collided with a police car on April 6, 2012.West Hollywood Sheriff's StationPhoto 3 of 30Raising Sextuplets dad Bryan Masche was arrested on September 11, 2010, in Arizona on charges of domestic violence and resisting arrest following a family bust-up, in which he allegedly shouted profanities at his wife in front of their children and threatened to "flatten" his father-in-law.HandoutPhoto 4 of 30Gossip Girl star Chace Crawford was arrested in his hometown of Plano, Texas, on June 4, 2010 after cops allegedly found him in possession of 2 ounces of marijuana.Plano Police DepartmentPhoto 5 of 30Heather Locklear was arrested for suspicion of driving under the influence on Sept. 27, 2008.Santa Barbara County Sheriff's DepartmentPhoto 6 of 30Burn Notice actor Jeffrey Donovan was arrested on the suspicion of drunken driving after being pulled over July 12, 2009 and failing a field sobriety test.Getty ImagesPhoto 7 of 30Kid Rock (real name Robert J. Ritchie) poses for a mug shot October 21. 2007 in DeKalb County, Georgia. Kid Rock was arrested in the early morning of October 21 after a fight at a Waffle House restaurant.DeKalb County Sheriff's Office via Getty ImagesPhoto 8 of 30On Dec. 5, 2007, Kiefer Sutherland reported to the Glendale City Jail to serve his 48-day sentence for DUI. It was his third DUI conviction.Getty ImagesPhoto 9 of 30Lindsay Lohan took another mugshot (her sixth, by our count) on Oct. 19, 2011 when a judge revoked her probation after deciding that Lohan has messed up too many times by failing to perform her community service. She was then immediately cuffed by a deputy and ordered held on $100,000 bail.Getty ImagesPhoto 10 of 30Lindsay Lohan was booked at Los Angeles County's Century Regional Detention Center at 10:35 a.m. EST on Sept. 24, 2010. She was thrown back behind bars because she failed at least one random drug test.L.A. Sheriff's DepartmentPhoto 11 of 30Lindsay Lohan fared a little bit better in her July 20 booking photo.LASDPhoto 12 of 30Lindsay Lohan was booked for DUI, possession of cocaine, transporting a narcotic into a custody facility and driving on a suspended license on June 24, 2007, just 11 days after leaving rehab. Three months earlier, she was arrested for DUI when her Mercedes SL-65 convertible hit a curb on Sunset Boulevard in Los Angeles.Los Angeles County Sheriff's Department via Getty ImagesPhoto 13 of 30Lindsay LohanLos Angeles County Sheriff's Department via Getty ImagesPhoto 14 of 30MARCH 19: In this booking photo provided by the Santa Monica Police Department, actress Lindsay Lohan is seen at the Santa Monica Police Station on March 19, 2013 in Santa Monica, California. Lindsay was ordered to turn herself in for booking after pleading no contest to the charge of reckless driving, providing false information to an officer and willfully resisting, obstructing or delaying an officer.Getty ImagesPhoto 15 of 30Sons of Anarchy star Mark Boone Junior was arrested on suspicion of assaulting an officer and resising arrest.Getty ImagesPhoto 16 of 30Mel Gibson, 55, had his mugshot taken when he was booked as part of his misdemeanor battery case in Los Angeles on March 16, 2011.Courtesy of the El Segundo Police DepartmentPhoto 17 of 30Mel Gibson was arrested July 28, 2006 with a blood alcohol reading of 0.12 percent. California's legal limit is 0.08.Getty ImagesPhoto 18 of 30Nicolas Cage appears in booking photo after being arrested on charges of domestic abuse in New Orleans on April 16, 2011. The actor reportedly dared police to arrest him after dragging his wife by the arm.Getty ImagesPhoto 19 of 30Nicole Richie was arrested for DUI on Dec 11, 2006. She allegedly told police she smoked pot and took a Vicodan before driving.Getty ImagesPhoto 20 of 30Paris Hilton was arrested on suspicion of cocaine possession in Las Vegas, Aug. 28, 2010. Don't feel too badly if her mugshot looks better than your last class photo. Hilton reportedly spent the day at the salon prior to being busted by cops.Getty ImagesPhoto 21 of 30Phil Spector poses for his mugshot photo on June 5, 2009 at North Kern State Prison in Delano, California. Spector received a 19-year sentence for second-degree murder for the February 2003 shooting death of actress Lana Clarkson.California Department of Corrections and Rehabilitation via Getty ImagesPhoto 22 of 30This is just one of Evi and Randy Quaid's mug shots, and we're sure it won't be the last. Having forfeited a $1 million bail for failing to appear in Santa Barbara this past October in a case involving charges of trespass, the couple are now hiding out in Canada.Santa Barbara County Sheriffs OfficePhoto 23 of 30On March 25, 2008 Bon Jovi guitarist Richie Sambora was arrested for DUI in Laguna Beach, Calif. after police officers witnessed him driving eratically in a black Hummer. Richie had gone to rehab twice in 2007 for alcohol abuse.Getty ImagesPhoto 24 of 30Robert Downey, Jr. was arrested by officers of the Culver City Police Department for being under the influence of a controlled substance on April 24, 2001.Culver City Police DepartmentPhoto 25 of 30Russell Brand HandoutPhoto 26 of 30Ryan O'Neal is seen in a mugshot September 17, 2008 in Los Angeles, California. Ryan O'Neil and his son Redmond O'Neil were arrested the morning of September 17, after Los Angeles County Sheriffs Deputies and probation officers went to O'Neil's Malibu home to check on Redmond O'Neil, who is serving three-years of probation for drug possession charges, and allegedly found drugs.Los Angeles County Sheriffs Department via Getty ImagesPhoto 27 of 30Nicole "Snooki" Polizzi was charged with disorderly conduct and creating a public nuisance following a rowdy afternoon beach party in July.Seaside Heights Police DeptPhoto 28 of 30Motley Crue singer Vince Neil was arrested in June on drunken driving charges after getting pulled over by police in his Lamborghini near the Las Vegas Strip.Las Vegas Police DeptPhoto 29 of 30Amanda Bynes most recent mugshot from May 23, 2013. Screen Cap. Photo 30 of 30Justin Bieber in Jan. 2014.Miami Police Miranda FurtadoPublished: March 20, 2013, 10:37 am Updated: 5 years ago A A A A A A Lindsay Lohan, Amanda Bynes, Snooki — and more Lindsay Lohan… Check out Hollywood's most infamous mugshots. Read more Articles from Miranda Furtado © COPYRIGHT - POSTMEDIA NEWS


text:
This section contains 469 words
(approx. 2 pages at 400 words per page)
Zero Hour Summary
Seven-year-old Mink Morris tells her mother that they're playing "invasion". All the children under ten join the game, while the rest of the street's residents go on with their normal lives. Mink directs activities.
Mink tells her mother that Drill is waiting for her. Drill is one of the invaders, maybe not from Mars but from another planet. He's having trouble invading Earth, and thought of contacting children using the fourth dimension. Drill promised no more baths and that kids can stay up until 10:00 and watch two shows on Saturday.
The older kids make fun of the game, and Mink says they'll kill those kids first. Drill promises to let the young kids rule the world. Mrs. Morris hears from a friend in Scranton, that children there are also playing invasion.
Mink says that zero hour is five o'clock. Mr. Morris...
(read more from the Zero Hour Summary)
This section contains 469 words
(approx. 2 pages at 400 words per page)


text:
Build Impactful Web Apps.
Learn about web architecture and deploy your creations live to the Internet. We'll teach you to build your own web app from scratch, from the user interface to the database.
Take this course in Cape Town only.
Learn about web architecture and deploy your creations live to the Internet. We'll teach you to build your own web app from scratch, from the user interface to the database.
Take this course in Cape Town only.
You use it almost nonstop—but do you know how it really works?
How to solve problems using code and think like a computer scientist.
The fundamentals of data storage, and SQL vs NoSQL.
Essential for any event-based paradigm. Callbacks and the power of promises.
Core skills to the world of web development.
The most popular coding language for modern web programming—a must know.
Communicate efficiently with other websites, and create your own service that other sites can use.
Learn to manage your code versions and collaborate on projects with other programmers.
"Before coming to iXperience, I had never even typed a single line of code. After 4 weeks I was able to create a web application for a new building security sign-in method, applying the skills I learned in the classroom in my internship."
"When I first signed up for iXperience, I expected to just learn how to make web applications. I didn't really know what exactly that would mean, but I never imagined it would contribute so heavily to me landing a future internship at Microsoft."
"We learned how to deal with real world frustrations like code not working or models running way too slow. Our teacher, Henry, supported our different levels of knowledge and needs in class. It was a very rewarding 4 weeks!"
"I directly applied the information gained in the classroom environment into an actual marketable skill. Where the classroom experience gave me the building blocks to become a good coder, the internship pushed me to make something of those blocks, teaching me how to think in terms of scalability."
"After two months of learning and adventuring in the most magical place I could imagine, I am returning to school confident in my decision to major in Computer Science and am relatively certain that I want to be a software engineer after I graduate."
Full-Stack Web Development is the most popular developer occupation today, according to the Stack Overflow 2016 Developer Survey. The profession and the community around it are thriving and re-inventing themselves continually. If you love being on the cutting edge, this is the career for you.
After your course, you can do an internship with one of our partner companies to hone your skillset, bolster your resume, and jumpstart your career.


text:
Visa Agencies in Bangladesh are using Alpha Net's high performance Virtual Servers to submit Visa Applications fast and on time. A high performance VPS from Alpha Net is connected to the Internet over a 1Gbps connection. With an extremely fast Internet connection, you can work on Remote Desktop as if you are working from USA, with no delay due to your slow and unreliable local Internet Connection.
A VPS helps you guarantee customer satisfaction every time.
Our low monthly payment options make a VPS very affordable and cost effective. Alpha Net provides VPS service to hundreds of Visa Agencies in Bangladesh. Only Alpha Net gives you One (1) Day Free Trial for your Indian VISA (eToken) Purposes.
Due to Indian Embassy Visa Policies, This Service is Currently Unavailable.


text:
Tuesday, 15 May 2012
The Very Cranky Bear by Nick Bland
I love the illustrations, the rhyme, the characters and the story itself!
Four friends (a zebra, moose, lion and sheep) find a cave to shelter in from the storm...until they disturb a very cranky bear.
They decide to cheer up the bear by thinking about the things that make them feel good.
The results are hilarious...although the cranky bear doesn't find it quite so amusing!
It's wonderful to read aloud with plenty of gentle frights and laughter.
This book will become a storytime regular. Highly recommended for 3+ audiences.
2 comments:
I actually wasn't so keen on this book when I did it for Simultaneous Storytime. I just felt that it didn't hit the mark or that the story wasn't taken quite far enough (if that makes any sense to you). I really loved another book of his - The Wrong Book - you should have a look if you get the chance.ReplyDelete
Though I will agree with you that the illustration of that bear is fantastic. I asked my Storytime kids if it reminded them of their mum or dad, got a few laughs from the parents.
I love hearing from you but I understand that blogger can be a frustrating experience for many.
Make sure you're logged into your account before writing your comment, otherwise blogger will eat it. I have occasionally found lost comments by hitting the back arrow button. All anonymous comments will be deleted.
If all else fails, you can contact me on my fb page or twitter.
Thanks for stopping by.


text:
It turns out nothing sells a house quite like a $10.5 million price chop. Just ask Oscar-winning actress Julia Roberts, who is reportedly already in agreement to sell her Hawaii home, after re-listing it last week at a discounted price.
The pending sale comes after the two-acre estate on the North Shore of Kauai saw its asking price lowered to $19.5 million. When it originally hit the market last year, the beachfront house was asking almost $30 million. It was listed for $21.95 million prior to last week's price cut.
The two-acre estate is known as the Faye Property, for former owner Hans Peter Faye, a prominent sugar plantation manager. It contains a classic 1917 plantation-style home, a guest house and 213 feet of beach frontage.
The estate totals seven bedrooms and four bathrooms with nearly 3,800 square feet of living space.
According to the LA Times, Roberts bought the property five years ago for $13.3 million.
Neal Norman of Hawaii Life Real Estate has the listing. [LAT]


text:
As the complexity of product configuration model is ever growing, Microsoft needs to use state of the art technology to address this complexity to meet customer requirements.
Microsoft has been developing the Z3 solver since 2008, it has reached a level of maturity, where it is now able to match and in some cases out perform the MSF solvers.
Furthermore the Z3 solver is an open source project with an active community, that is contiously evolving. For product configuration in Dynamics AX 2012 it means that there is an opportunity to leverage the Z3 to provide better performance and in the future new solving capabilities for product configuration.


text:
Eleven-year-old Louise Cunningham watches with wonder as a visit from her unusual uncle gives her ordinary small town a glow of something mysterious and magical.
Tim, Jane, and the twins, Barnaby A and Barnaby B, are four rather ordinary children. They just happen to have extraordinarily horrible parents. And that requires some extraordinary scheming.
A sensitive and moving story of a wide-eyed young girl growing up at the beginning of the twentieth century and the influence of the farm community around her.
Oh, it is so boring to be royalty! And unnerving, too, because in just a few days Princess Patircia Priscilla will turn sixteen, the age at which she must choose her husband-to-be! And all of the contenders are soooo disgusting!
In Boston's famous Public Garden, fourteen-year-old Enid and her four-year-old pal, Tom Terrific, learn lots about life from new friendships with a bag lady and a saxophone player.
This is the story of a dog who tells his own tale. As a pup he is separated from his mother and siblings. Through it all, Keeper can't forget his long lost little sister. If only they could be together again, life would be perfect. But an old enemy is watching and waiting to make his move.
Twelve-year-old Rabble Starkey's mother is hired by Mrs. Bigelow to look after her children while she's in the hospital. Living in that huge house, Rabble feels she's finally found a home. But soon she and her mother must question what's really best for them.
Ten-year-old Annemarie Johansen and her best friend Ellen Rosen often think about life before the war. But it's now 1943 and their life in Copenhagen is filled with school, food shortages, and the Nazi soldiers marching in their town.


text:
Global warming won't mean more storms: Big storms to get bigger, small storms to shrink, experts predict
Filed Under News | Leave a Comment
"We know that with global warming we'll get more evaporation of the oceans," said Frederic Laliberte, a research associate at U of T's physics department and lead author of a study published this week in Science. "But circulation in the atmosphere is like a heat engine that requires fuel to do work, just like any combustion engine or a convection engine."
The atmosphere's work as a heat engine occurs when an air mass near the surface takes up water through evaporation as it is warmed by the Sun and moves closer to the Equator. The warmer the air mass is, the more water it takes up. As it reaches the Equator, it begins to ascend through the atmosphere, eventually cooling as it radiates heat out into space. Cool air can hold less moisture than warm air, so as the air cools, condensation occurs, which releases heat. When enough heat is released, air begins to rise even further, pulling more air behind it producing a thunderstorm. The ultimate "output" of this atmospheric engine is the amount of heat and moisture that is redistributed between the Equator and the North and South Poles.
"By viewing the atmospheric circulation as a heat engine, we were able to rely on the laws of thermodynamics to analyze how the circulation would change in a simulation of global warming," said Laliberte. "We used these laws to quantify how the increase in water vapour that would result from global warming would influence the strength of the atmospheric circulation."
The researchers borrowed techniques from oceanography and looked at observations and climate simulations. Their approach allowed them to test global warming scenarios and measure the output of atmospheric circulation under warming conditions.
"We came up with an improved technique to comprehensively describe how air masses change as they move from the Equator to the poles and back, which let us put a number on the energy efficiency of the atmospheric heat engine and measure its output," said Laliberte.
The scientists concluded that the increase in water vapour was making the process less efficient by evaporating water into air that is not already saturated with water vapour. They showed that this inefficiency limited the strengthening of atmospheric circulation, though not in a uniform manner. Air masses that are able to reach the top of the atmosphere are strengthened, while those that can not are weakened.
"Put more simply, powerful storms are strengthened at the expense of weaker storms," said Laliberte. "We believe atmospheric circulation will adapt to this less efficient form of heat transfer and we will see either fewer storms overall or at least a weakening of the most common, weaker storms."
Story Source:
The above story is based on materials provided by University of Toronto. Note: Materials may be edited for content and length.
Journal Reference:
- F. Laliberte, J. Zika, L. Mudryk, P. J. Kushner, J. Kjellsson, K. Doos. Constrained work output of the moist atmospheric heat engine in a warming climate.Science, 2015; 347 (6221): 540 DOI: 10.1126/science.1257103
University of Toronto. "Global warming won't mean more storms: Big storms to get bigger, small storms to shrink, experts predict." ScienceDaily. ScienceDaily, 29 January 2015. <www.sciencedaily.com/releases/2015/01/150129143040.htm>.
Smothered oceans: Extreme oxygen loss in oceans accompanied past global climate change
Filed Under News | Leave a Comment
In the study, published in the journal PLOS ONE, researchers analyzed marine sediment cores from different world regions to document the extent to which low oxygen zones in the ocean have expanded in the past, due to climate change.
From the subarctic Pacific to the Chilean margins, they found evidence of extreme oxygen loss stretching from the upper ocean to about 3,000 meters deep. In some oceanic regions, such loss took place over a time period of 100 years or less.
"This is a global story that knits these regions together and shows that when you warm the planet rapidly, whole ocean basins can lose oxygen very abruptly and very extensively," said lead author Sarah Moffitt, a postdoctoral scholar with the UC Davis Bodega Marine Laboratory and formerly a Ph.D. student with the Graduate Group in Ecology.
Marine organisms, from salmon and sardines to crab and oysters, depend on oxygen to exist. Adapting to an ocean environment with rapidly dropping oxygen levels would require a major reorganization of living things and their habitats, much as today polar species on land are retreating to higher, cooler latitudes.
The researchers chose the deglaciation period because it was a time of rising global temperatures, atmospheric carbon dioxide and sea levels — many of the global climate change signs the Earth is experiencing now.
"Our modern ocean is moving into a state that has no precedent in human history," Moffitt said. "The potential for our oceans to look very, very different in 100-150 years is real. How do you use the best available science to care for these critical resources in the future? Resource managers and conservationists can use science like this to guide a thoughtful, precautionary approach to environmental management."
The study's co-authors include: Russell Moffitt with the Marine Conservation Institute; Tessa Hill, professor in the UC Davis Department of Earth and Planetary Sciences and at the Bodega Marine Laboratory; Wilson Sauthoff and Catherine Davis of the Department of Earth and Planetary Sciences; and Kathryn Hewett, UC Davis Department of Civil and Environmental Engineering.
The study arose from a graduate level course that was taught at UC Davis in winter 2013 by Hill. The research was supported by the National Science Foundation.
Story Source:
The above story is based on materials provided by University of California – Davis.Note: Materials may be edited for content and length.
Journal Reference:
- Sarah E. Moffitt, Russell A. Moffitt, Wilson Sauthoff, Catherine V. Davis, Kathryn Hewett, Tessa M. Hill. Paleoceanographic Insights on Recent Oxygen Minimum Zone Expansion: Lessons for Modern Oceanography. PLOS ONE, 2015; 10 (1): e0115246 DOI: 10.1371/journal.pone.0115246
University of California – Davis. "Smothered oceans: Extreme oxygen loss in oceans accompanied past global climate change." ScienceDaily. ScienceDaily, 28 January 2015. <www.sciencedaily.com/releases/2015/01/150128152155.htm>.
Brain region vulnerable to aging is larger in those with longevity gene variant
Filed Under News | Leave a Comment
The finding bolsters their previous discovery that middle-aged and older people who carry a single copy of the KLOTHO allele, called KL-VS, performed better on a wide range of cognitive tests. When they modeled KL-VS in mice, they found this strengthened the connections between neurons and enhanced learning and memory.
KLOTHO codes for a protein, called klotho, which is produced in the kidney and brain and regulates many different processes in the body. About one in five people carry a single copy of KL-VS, which increases klotho levels and is associated with a longer lifespan and better heart and kidney function. A small minority, about 3 percent, carries two copies, which is associated with a shorter lifespan.
In the current study, published in Annals of Clinical and Translational Neurology, researchers scanned the brains of 422 cognitively normal men and women aged 53 and older to see if the size of any brain area correlated with carrying one, two or no copies of the allele.
They found that the KLOTHO gene variant predicted the size of a region called the right dorsolateral prefrontal cortex (rDLPFC), which is especially vulnerable to atrophy as people age. Deterioration in this area may be one reason why older people have difficulty suppressing distracting information and doing more than one thing at a time.
Researchers found that the rDLPFC shrank with age in all three groups, but those with one copy of KL-VS, about a quarter of the study group, had larger volumes than either non-carriers or those with two copies. Researchers also found that the size of the rDLPFC predicted how well the three groups performed on cognitive tests, such as working memory — the ability to keep a small amount of newly acquired information in mind — and processing speed. Both tests are considered to be good measures of the planning and decision-making functions that the rDLPFC controls.
"We've known for a long time that people lose cognitive abilities as they age, but now we're beginning to understand that factors like klotho can give people a boost and confer resilience in aging," said senior author Dena Dubal, MD, PhD, assistant professor of neurology at UCSF and the David A. Coulter Endowed Chair in Aging and Neurodegenerative Disease. "Genetic variation in KLOTHO could help us predict brain health and find ways to protect people from the devastating diseases that happen to us as we grow old, like Alzheimer's and other dementias."
In statistical tests, the researchers concluded that the larger rDLPFC volumes seen in single copy KL-VS carriers accounted for just 12 percent of the overall effect that the variant had on the abilities tested. However, the allele may have other effects on the brain, such as increasing levels or changing the actions of the klotho protein to enhance synaptic plasticity, or the connections between neurons. In a previous experiment, they found that raising klotho in mice increased the action of a cell receptor critical to forming memories.
"The brain region enhanced by genetic variation in KLOTHO is vulnerable in aging and several psychiatric and neurologic diseases including schizophrenia, depression, substance abuse, and frontotemporal dementia," said Jennifer Yokoyama, PhD, first author and assistant professor of neurology at UCSF. "In this case, bigger size means better function. It will be important to determine whether the structural boost associated with carrying one copy of KL-VS can offset the cognitive deficits caused by disease."
Story Source:
The above story is based on materials provided by University of California, San Francisco (UCSF). The original article was written by Laura Kurtzman. Note: Materials may be edited for content and length.
Journal Reference:
- Jennifer S. Yokoyama, Virginia E. Sturm, Luke W. Bonham, Eric Klein, Konstantinos Arfanakis, Lei Yu, Giovanni Coppola, Joel H. Kramer, David A. Bennett, Bruce L. Miller, Dena B. Dubal. Variation in longevity geneKLOTHOis associated with greater cortical volumes. Annals of Clinical and Translational Neurology, 2015; DOI: 10.1002/acn3.161
University of California, San Francisco (UCSF). "Brain region vulnerable to aging is larger in those with longevity gene variant." ScienceDaily. ScienceDaily, 27 January 2015. <www.sciencedaily.com/releases/2015/01/150127121158.htm>.
Entanglement on a chip: Breakthrough promises secure communications and faster computers
Filed Under News | Leave a Comment
Entanglement — the instantaneous connection between two particles no matter their distance apart — is one of the most intriguing and promising phenomena in all of physics. Properly harnessed, entangled photons could revolutionize computing, communications, and cyber security. Though readily created in the lab and by comparatively large-scale optoelectronic components, a practical source of entangled photons that can fit onto an ordinary computer chip has been elusive.
New research, reported today in The Optical Society's (OSA) new high-impact journal Optica, describes how a team of scientists has developed, for the first time, a microscopic component that is small enough to fit onto a standard silicon chip that can generate a continuous supply of entangled photons.
The new design is based on an established silicon technology known as a micro-ring resonator. These resonators are actually loops that are etched onto silicon wafers that can corral and then reemit particles of light. By tailoring the design of this resonator, the researchers created a novel source of entangled photons that is incredibly small and highly efficient, making it an ideal on-chip component.
"The main advantage of our new source is that it is at the same time small, bright, and silicon based," said Daniele Bajoni, a researcher at the Università degli Studi di Pavia in Italy and co-author on the paper. "The diameter of the ring resonator is a mere 20 microns, which is about one-tenth of the width of a human hair. Previous sources were hundreds of times larger than the one we developed."
From Entanglement to Innovation
Scientists and engineers have long recognized the enormous practical potential of entangled photons. This curious manifestation of quantum physics, which Einstein referred to as "spooky action at a distance," has two important implications in real-world technology.
First, if something acts on one of the entangled photons then the other one will respond to that action instantly, even if it is on the opposite side of a computer chip or even the opposite side of the Galaxy. This behavior could be harnessed to increase the power and speed of computations. The second implication is that the two photons can be considered to be, in some sense, a single entity, which would allow for new communication protocols that are immune to spying.
This seemingly impossible behavior is essential, therefore, for the development of certain next-generation technologies, such as computers that are vastly more powerful than even today's most advanced supercomputers, and secure telecommunications.
Creating Entanglement on a Chip
To bring these new technologies to fruition, however, requires a new class of entangled photon emitters: ones that can be readily incorporated into existing silicon chip technologies. Achieving this goal has been very challenging.
To date, entangled photon emitters — which are principally made from specially designed crystals — could be scaled down to only a few millimeters in size, which is still many orders of magnitude too large for on-chip applications. In addition, these emitters require a great deal of power, which is a valuable commodity in telecommunications and computing.
To overcome these challenges, the researchers explored the potential of ring resonators as a new source for entangled photons. These well-established optoelectronic components can be easily etched onto a silicon wafer in the same manner that other components on semiconductor chips are fashioned. To "pump," or power, the resonator, a laser beam is directed along an optical fiber to the input side of the sample, and then coupled to the resonator where the photons race around the ring. This creates an ideal environment for the photons to mingle and become entangled.
As photons exited the resonator, the researchers were able to observe that a remarkably high percentage of them exhibited the telltale characteristics of entanglement.
"Our device is capable of emitting light with striking quantum mechanical properties never observed in an integrated source," said Bajoni. "The rate at which the entangled photons are generated is unprecedented for a silicon integrated source, and comparable with that available from bulk crystals that must be pumped by very strong lasers."
Applications and Future Technology
The researchers believe their work is particularly relevant because it demonstrates, for the first time, a quintessential quantum effect, entanglement, in a well-established technology.
"In the last few years, silicon integrated devices have been developed to filter and route light, mainly for telecommunication applications," observed Bajoni. "Our micro-ring resonators can be readily used alongside these devices, moving us toward the ability to fully harness entanglement on a chip." As a result, this research could facilitate the adoption of quantum information technologies, particularly quantum cryptography protocols, which would ensure secure communications in ways that classical cryptography protocols cannot.
According to Bajoni and his colleagues, these protocols have already been demonstrated and tested. What has been missing was a cheap, small, and reliable source of entangled photons capable of propagation in fiber networks, a problem that is apparently solved by their innovation.
Story Source:
The above story is based on materials provided by The Optical Society. Note: Materials may be edited for content and length.
Journal Reference:
- Davide Grassani, Stefano Azzini, Marco Liscidini, Matteo Galli, Michael J. Strain, Marc Sorel, J. E. Sipe, Daniele Bajoni. Micrometer-scale integrated silicon source of time-energy entangled photons. Optica, 2015; 2 (2): 88 DOI:10.1364/OPTICA.2.000088
The Optical Society. "Entanglement on a chip: Breakthrough promises secure communications and faster computers." ScienceDaily. ScienceDaily, 26 January 2015. <www.sciencedaily.com/releases/2015/01/150126095707.htm>.
Filed Under News, What's New | Leave a Comment
Growth at Target Health – Expanding to New Jersey
Target Health Inc., established in 1993, is expanding to New Jersey. Our software programming department, headed by Senior Director, Joonhyuk Choi, will be located near the Meadowlands, not far from New York City. Our executive offices and clinical, data management, statistics and business development departments will remain on the 23 and 24th floors at 261 Madison Avenue.
Abstract Expressionist and Master Nature Photographer
Our friend and colleague, James Farley, Clinical Data Manager at TransTech Pharma LLC and subscriber to ON TARGET newsletter, is sharing another great photo, this time a gorgeous view of the pier – just after Sunset – at Holden Beach, NC.
Sunset at Holden Beach, NC, 2015 ©JFarleyPhotography.com
ON TARGET is the newsletter of Target Health Inc., a NYC-based, full-service, contract research organization (eCRO), providing strategic planning, regulatory affairs, clinical research, data management, biostatistics, medical writing and software services to the pharmaceutical and device industries, including the paperless clinical trial.
For more information about Target Health contact Warren Pearlson (212-681-2100 ext. 104). For additional information about software tools for paperless clinical trials, please also feel free to contact Dr. Jules T. Mitchel or Ms. Joyce Hays. The Target Health software tools are designed to partner with both CROs and Sponsors. Please visit the Target Health Website.
Joyce Hays, Founder and Editor in Chief of On Target
Jules Mitchel, Editor
Filed Under News | Leave a Comment
Scientists Reprogram Fat Cells to Increase Fat Burning
Scientists have now discovered how fat cells can be reprogrammed to burn fat instead of storing it. By analyzing molecular processes, scientists have described for the first time how white fat cells are converted into brown fat cells.
Cells responsible for storing 1) ___ can be converted into cells that burn fat and keep you thinner and healthier. Scientists have now discovered how this conversion happens. We've mapped the fat cells' genomes and identified a protein which activates specific 2) ___ that reprogram the fat cells to burn fat instead of storing it, says Professor S. Mandrup from the department of biochemistry and molecular biology at the University of Southern Denmark (SDU). The study's findings, recently published the January 2015 journal, Genes & Development, are a crucial step on the way to developing 3) ___ that can make the body transform fat into energy instead of storing it.
Our body contains three different types of fat cells: White cells, which store fat derived from food so that you put on weight if you eat too much; 4) ___ fat cells, which convert fat into energy instead of storing it; Brite fat cells are beige/brownish in color (brite is short for brown-in-white). Like brown cells they convert fat into heat. Scientists have long been interested in brite fat cells because it has been shown that white fat cells can be browned and turned into brite so that they burn fat instead of storing it. Studies show that overweight people have a lot of white cells in their fatty 5) ___. We've known for a long time that exposure to the cold, for example, can cause the body to produce more brite fat cells which produce heat, although we have not known much about which molecular mechanisms are at play.
Anti-Diabetic Medication Browns Cells
In order better to understand how fat-storing white cells can become fat-burning brite cells, scientists at SDU have grown white cells in the laboratory and added a medication previously used to increase the insulin sensitivity of 6) ___ patients. The medication known as rosiglitazone (Avandia) makes the fat cells turn brown thus making them brite — but exactly what effect the drug has on the cells at the molecular level has been unclear until now. To study this, the scientists used advanced gene sequencing technology to map and analyze the genome of both the white and brite cells in order to find out which genes are active when the 7) ___ cells turn brite.
A Specific Protein Activates Genes
Their analyses did not only show where in the fat cells' genome there is activity when white cells are converted to brite cells, but also that a specific 8) ___, known as KLF11, has to be present for the cells to be reprogrammed to burn fat instead of storing it. It's clear that KLF11 finds the genes in the cells which are active when white fat cells are being converted into brite cells. KLF11 is already known as a protein important to the functionality of insulin-producing beta-cells in the pancreas, but with our study we have demonstrated, for the first time that the protein is also necessary for white fat cells to be reprogrammed to brite fat cells.
White fat cells have been known about for many years, but it was not until 2009 that scientists discovered that adult human beings also have so-called brown fat tissue. The fatty tissue is referred to as brown because of its reddish-brown color when viewed through a microscope. The brown color occurs because the cells contain many mitochondria and 9) ___ vessels. Over the past decade it was also discovered that humans have brite fat cells. Brite fat cells burn fat just like the brown ones. In other words: the more brite and brown fat cells you have the more 10) ___ you burn. Unlike the entirely brown fat cells, brite cells are produced from already-existing white fat tissue of the kind we have most of in our body. Scientists still have a lot to learn about brite fat cells. They do not know, for instance, whether we can cause more brite fat cells to be produced, e.g. by eating specific foods. It is not known, either, whether brite cells can only be produced by converting white cells, or whether the body can produce its own new brite fat cells. In the long term, it will be possible to use the discovery to develop new medication which can impact on precisely those areas in the fat cells' genome. This will make it possible to prevent overweight people from developing insulin intolerance and diabetes or other diseases related to 11) ___. We know more about which buttons we have to push to increase specific processes in the cells which activate the browning process. KLF11 is just one of the factors that determines which genes are active, researchers are certain there are many others.
Jacob B. Hansen, an associate professor at the Department of Biology of the University of Copenhagen, who studies brown fat cells, says that the new results represent an important step towards understanding how fat cell conversion takes place in humans. The molecular understanding of how brite is produced and much of what we do know comes from experiments on mice, however, this study is entirely based on 12) ___ cell material. Experiments on mice have shown that KFL11 can regulate parts of the biology of brown fat cells, but in this study, the scientists used advanced methods which enabled them to characterize the browning process in great detail. This was much more elegant than the work previously done on mice because they've observed all the genes in one go and found the areas in the genome of the cells which KLF11 binds to. Pills against obesity are closer to reality. The result certainly is a step in the direction of a cure which e.g. can reduce the risk of people developing type 2 diabetes and countering other health issues related to being overweight. The potential is interesting, because the better we understand the biology of fat cells, the closer we'll get to being able to design medication which can cause the body to produce more beige and brown fat cells, which experiments on mice have shown effective to improve glucose tolerance. But this doesn't mean that in five years will have a magic pill against obesity, Hansen says. The work done at SDU is basic science, which improves our knowledge of the process known as browning, but a lot more research will have to be done before we fully understand the process and its significance. The genome of white adipocytes, has been investigated and is reprogrammed during browning using advanced genome sequencing technologies. Browning has been stimulated in human white adipocytes by a drug used to treat type II diabetes and compared to white and brite fat cells. This comparison showed that 13) ___ fat cells have distinct gene programs which, when active, make these cells particularly energy-consuming. By identifying the areas of the genome that are directly involved in the reprogramming, an important factor has been identified in the process — the gene regulatory protein KLF11 (Kruppel Like Factor-11), which is found in all fat cells, is required for the reprogramming to take place. This research has been a long process, taking four years to get the results being published. The discovery of the brite fat cell mechanisms and the specific regulatory areas brings scientists closer to understanding how reprogramming of white fat cells takes place. This knowledge potentially means, that in the future drugs can be 14) ___to activate the genomic regions and browning factors like KLF11 in the treatment of obesity.
ANSWERS: 1) fat; 2) genes; 3) drugs; 4) brown; 5) tissue; 6) diabetes; 7) white; 8) protein; 9) blood; 10) energy; 11) obesity; 12) human; 13) brite; 14) targeted
Filed Under History of Medicine, News | Leave a Comment
The Ob(Lep) Gene and Weight Loss
Structure of the obese protein leptin-E100
The Ob(Lep) gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans. Human leptin is a 16 kDa protein of 167 amino acids. Leptin should not to be confused with Lectin or Lecithin.
Leptin (from Greek meaning thin), the satiety hormone, is a hormone made by fat cells which regulates the amount of fat stored in the body. It does this by adjusting both the sensation of hunger, and adjusting energy expenditures. Hunger is inhibited (satiety) when the amount of fat stored reaches a certain level. Leptin is then secreted and circulates through the body, eventually activating leptin receptors in the arcuate nucleus of the hypothalamus. Energy expenditure is increased both by the signal to the brain, and directly via leptin receptors on peripheral targets. The effect of leptin is opposite to that of ghrelin, the hunger hormone. Ghrelin receptors are on the same brain cells as leptin receptors, so these cells receive competing satiety and hunger signals. Leptin and ghrelin, along with many other hormones, participate in the complex process of energy homeostasis. Although regulation of fat stores is deemed to be the primary function of leptin, it also plays a role in other physiological processes, as evidenced by its multiple sites of synthesis other than fat cells, and the multiple cell types beside hypothalamic cells which have leptin receptors. Many of these additional functions are yet to be defined.
Leptin was approved in the United States in 2014 for use in congenital leptin deficiency and generalized lipodystrophy.
An analog of human leptin metreleptin (trade name Myalept) was first approved in Japan in 2013, and in the United States (US) in February 2014. In the US it is indicated as a treatment for complications of leptin deficiency, and for the diabetes and hypertriglyceridemia associated with congenital or acquired generalized lipodystrophy. Leptin is known to interact with amylin, a hormone involved in gastric emptying and creating a feeling of fullness. When both leptin and amylin were given to obese, leptin-resistant rats, sustained weight loss was seen. Due to its apparent ability to reverse leptin resistance, amylin has been suggested as possible therapy for obesity.
Historically, the existence of a hormone regulating hunger and energy expenditure was hypothesized based on studies of mutant obese mice that arose at random within a mouse colony at the Jackson Laboratory in 1950. Mice homozygous for the ob mutation (ob/ob) ate voraciously and were massively obese. In the 1960s, a second mutation causing obesity and a similar phenotype was identified by Douglas Coleman, also at the Jackson Laboratory, and was named diabetes (db), as both ob/ob and db/db were obese. Rudolph Leibel and Jeffrey M. Friedman reported the mapping of the ob gene in 1990. Consistent with Coleman's and Leibel's hypothesis, several subsequent studies from Leibel's and Friedman's labs and other groups confirmed that the ob gene encoded a novel hormone that circulated in blood and that could suppress food intake and body weight in ob and wild type mice, but not in db mice.
In 1994, with the ob gene isolated, Friedman reported the discovery of the gene. In 1995, Caro's laboratory provided evidence that the mutations present in the mouse ob gene did not occur in humans. Furthermore the ob gene expression was increased in human obesity, which led to postulate the concept of leptin resistance. At the suggestion of Roger Guillemin, Friedman named this new hormone leptin from the Greek lepto meaning thin. Leptin was the first fat cell-derived hormone to be discovered. Subsequent studies confirmed that the db gene encodes the leptin receptor and that it is expressed in the hypothalamus, a region of the brain known to regulate the sensation of hunger and body weight.
Coleman and Friedman have been awarded numerous prizes acknowledging their roles in discovery of leptin, including the Gairdner Foundation International Award(2005), the Shaw Prize (2009), the Lasker Award, the BBVA Prize and the King Faisal International Prize. The discovery of leptin has been documented in a series of books including Fat: Fighting the Obesity Epidemic by Robert Pool, The Hungry Gene by Ellen Ruppel Shell, and Rethinking Thin: The New Science of Weight Loss and the Myths and Realities of Dieting by Gina Kolata.Fat: Fighting the Obesity Epidemic and Rethinking Thin: The New Science of Weight Loss and the Myths and Realities of Dieting review the work in the Friedman laboratory that led to the cloning of the ob gene.
A mutant leptin was first described in 1997, and subsequently six additional mutations were described. All of those affected were from Eastern countries; and all had variants of leptin not detected by the standard immunoreactive technique. The most recently described eighth mutant reported in January2015 is unique in that it is detected by the standard immunoreactive technique, indicating that leptin levels are elevated but the leptin is nonfunctional. These eight mutations all cause extreme obesity in infancy, with hyperphagia. Leptin is produced primarily in the adipocytes of white adipose tissue. It is also produced by brown adipose tissue, placenta (syncytiotrophoblasts), ovaries, skeletal muscle, stomach (the lower part of the fundic glands), mammary epithelial cells, bone marrow, pituitary, liver, gastric chief cells and P/D1 cells. Leptin circulates in blood in free form, bound to proteins and leptin levels vary exponentially, not linearly, with fat mass. Leptin levels in blood are higher between midnight and early morning, perhaps suppressing appetite during the night. The diurnal rhythm of blood leptin levels can be modified by meal-timing. In humans, many instances are seen where Leptin dissociates from the strict role of communicating nutritional status between body and brain and no longer correlates with body fat levels:
1. Leptin level is decreased after short-term fasting (24-72 hours), even when changes in fat mass are not observed.
2. Leptin plays a critical role in the adaptive response to starvation.
3. In obese patients with obstructive sleep apnea, leptin level is increased, but decreased after the administration of continuous positive airway pressure. In non-obese individuals, however, restful sleep (i.e., 8-12 hours of unbroken sleep) can increase leptin to normal levels.
4. Serum level of leptin is reduced by sleep deprivation.
5. Leptin level is increased by perceived emotional stress.
6. Leptin level is decreased by increases in testosterone levels and increased by increases in estrogen levels.
7. Leptin level is chronically reduced by physical exercise training.
8. Leptin level is increased by dexamethasone.
9. Leptin level is increased by insulin.
10. Leptin levels are paradoxically increased in obesity.
Filed Under News | Leave a Comment
Brain Recalls Old Memories Via New Pathways
Shift in fear retrieval circuitry eyed in anxiety disorders – NIH-funded studies
People with anxiety disorders, such as post traumatic stress disorder (PTSD), often experience prolonged and exaggerated fearfulness. Now, an animal study suggests that this might involve disruption of a gradual shifting of brain circuitry for retrieving fear memories. Researchers funded by the National Institutes of Health have discovered in rats that an old fear memory is recalled by a separate brain pathway from the one originally used to recall it when it was fresh.
Results of the study, published online in the journal Nature (19 January 2015) showed that after rats were conditioned to fear a tone associated with a mild shock, their overt behavior remained unchanged over time, but the pathway engaged in remembering the traumatic event took a detour, perhaps increasing its staying power. Immediately after fear conditioning, a circuit running from the prefrontal cortex, the executive hub, to part of the amygdala, the fear hub, was engaged to retrieve the memory. But several days later, the authors discovered that retrieval had migrated to a different circuit – from the prefrontal cortex to an area in the thalamus, called the paraventricular region (PVT). The PVT, in turn, communicates with a different central part of the amygdala that orchestrates fear learning and expression. The authors used a genetic/laser technique called optogenetics to spot the moving memory. This technique can activate or silence specific pathways to tease them apart. The authors hypothesized that the PVT may serve to integrate fear with other adaptive responses, such as stress, thereby strengthening the fear memory, and that people with anxiety disorders, any disruption of timing-dependent regulation in retrieval circuits might worsen fear responses occurring long after a traumatic event.
In the same issue of Nature, Bo Li, Ph.D. and Mario Penzo, Ph.D. of Cold Spring Harbor Laboratory in New York, and colleagues, reveal how the long-term fear memory circuit works in mice to translate detection of stress into adaptive behaviors. These authors independently discovered the same shift in memory retrieval circuitry occurring, over time, after fear conditioning in mice. Using powerful genetic-chemical, as well as optogenetic, methods to experimentally switch pathways on and off, they showed conclusively that neurons originating in the PVT regulate fear processing by acting on a class of neurons that store fear memories in the central amygdala area. This article traced this activity in the PVT to the action of a messenger chemical, brain-derived neurotrophic factor (BDNF), which has previously been implicated in mood and anxiety disorders. For example, altered BDNF expression has been linked to PTSD. BDNF from the PVT, working via a specific receptor, activated the memory-storing amygdala neurons. Simply infusing BDNF into the central amygdala area caused mice to freeze in fear, suggesting that it not only enables the formation of fear memories, but also the expression of fear responses.
Filed Under News | Leave a Comment
Registering Eye Movements During Reading in Alzheimer's Disease
Reading requires the fine integration of attention, ocular movements, word identification, and language comprehension, among other cognitive parameters. Several of the associated cognitive processes such as working memory and semantic memory are known to be impaired by Alzheimer's disease (AD). As a result, a study published online in the Journal of Clinical and Experimental Neuropsychology (28 February 2014) analyzed eye movement behavior of 18 patients with probable AD and 40 age-matched controls during Spanish sentence reading.
Results showed that controls focused mainly on word properties and considered syntactic and semantic structures. In addition, the controls' knowledge and prediction about sentence meaning and grammatical structure were quite evident when considering some aspects of visual exploration, such as word skipping, and forward saccades. Saccades are quick, simultaneous movements of both eyes between two phases of fixation in the same direction. By contrast, in the AD group, the predictability effect of the upcoming word was absent, visual exploration was less focused, fixations were much longer, and outgoing saccade amplitudes were smaller than those in controls.
According to the authors, the altered visual exploration and the absence of a contextual predictability effect might be related to impairments in working memory and long-term memory retrieval functions and that these eye movement measures demonstrate considerable sensitivity with respect to evaluating cognitive processes in AD. As a result, these measures could provide a user-friendly marker of early disease symptoms and of its posterior progression.
Filed Under News, Regulatory | Leave a Comment
FDA Clears First System of Mobile Medical Apps for Continuous Glucose Monitoring
Diabetes is a serious, chronic metabolic condition where the body is unable to convert glucose into the energy needed to carry out daily activities. An estimated 25.8 million people in the U.S. – about 215,000 of them under age 20 – have diabetes. If left untreated, high blood glucose levels (hyperglycemia) can lead to serious long-term problems such as stroke, heart disease, and damage to the eyes, kidneys and nerves.
A continuous glucose monitor (CGM) is a device that includes a small, wire-like sensor inserted just under the skin that provides a steady stream of information about glucose levels in the fluid around the cells (interstitial fluid). CGMs are worn externally and continuously display an estimate of blood glucose levels, and the direction and rate of change of these estimates. When used along with a blood glucose meter, CGM information can help people with diabetes detect when blood glucose values are approaching dangerously high and dangerously low levels.
The FDA has cleared for marketing the first set of mobile medical apps that allow people with diabetes to automatically and securely share data from a CGM with other people in real-time using an Apple mobile device such as an iPhone. The Dexcom Share Direct Secondary Displays system's data-sharing capability allows caregivers to a person with diabetes to monitor that individual's blood sugar levels remotely through a legally marketed device that is available on mobile devices. Devices like the Dexcom Share were previously available through open source efforts, but were not in compliance with regulatory requirements. The Dexcom Share system is the first of its kind to offer a legally marketed solution for real-time remote monitoring of a patient's CGM data.
The Dexcom Share system displays data from the G4 Platinum CGM System using two apps: one installed on the patient's mobile device and one installed on the mobile device of another person. Using Dexcom Share's mobile medical app, the user can designate people (followers) with whom to share their CGM data. The app receives real-time CGM data directly from the G4 Platinum System CGM receiver and transmits it to a Web-based storage location. The app of the follower can then download the CGM data and display it in real-time.
The FDA reviewed data for the Dexcom Share system through the de novo classification process, a regulatory pathway for low- to moderate-risk medical devices that are novel and not substantially equivalent to any legally marketed device. Data provided by the device maker showed the device functions as intended and transmits data accurately and securely.
Because the device is low to moderate risk, a regulatory concept when classifying devices not requiring a Pre-Market Approval (PMA) application, the FDA has classified the device as class II exempt from premarket submissions. In the future, manufacturers wishing to market devices like the Dexcom Share system will not need premarket clearance by the FDA prior to marketing, but they will still need to register and list their device with the agency, as well as follow other applicable laws and regulations.
Alberto Gutierrez, PhD, Director of the Office of In Vitro Diagnostics and Radiological Health in the FDA's Center for Devices and Radiological Health said that Exempting devices from premarket review is part of the FDA's effort to ensure these products provide accurate and reliable results while still encouraging the development of devices that meet the needs of people living with diabetes and their caregivers.
The Dexcom Share system does not replace real-time continuous glucose monitoring or standard home blood glucose monitoring. It is also not intended to be used by the patient in place of a primary display device. Additionally, CGM values alone are not approved to determine dosing of diabetes medications. CGMs must be calibrated by blood glucose meters, and treatment decisions, such as insulin dosing, should be based on readings from a blood glucose meter.
The Dexcom Share system is manufactured by Dexcom, Inc., located in San Diego, California.


text:
Orange County envies no other region of the world for entertainment. New York, Paris, Graceland; the OC boasts as much enjoyment per square mile as anywhere, and delivers a higher quality of it. Everyone knows about the terrific surfing and the roller coasters, but for a slightly lesser known avenue of amusement, wind through the county's beautiful college campuses and explore their brilliant theater arts productions.
Metamorphoses – A Play
Saddleback College
McKinney Theatre
28000 Marguerite Parkway
Mission Viejo, CA 92692
(949) 582-4656
Nov. 7 to 10
Writer and director Mary Zimmerman brings her vast experience and extraordinary talents to Saddleback's McKinney Theater with her Tony Award-winning adaptation of Ovid's epic poem. The Northwestern University college production, turned off-Broadway, turned Broadway smash hit, comes to Orange County for four stunning performances. Trace six familiar Greek myths in this extravagant, imaginative and even humorous presentation.
Spring Awakening
Chapman University
Waltmar Theatre
1 University Drive
Orange, CA 92866
(714) 997-6812
Nov. 7 to 9
Winner of eight Tony Awards, "Spring Awakening" will open your eyes to a new way of experiencing dramatic theater. Touted as a musical drama, this adaptation of Frank Wedekind's 19th century masterpiece is a moving, entertaining exploration of youth, morality, desperation and rock and roll. Director Jim Taulli's musical and theatrical talents span decades and he has graced campuses throughout Orange County. This production of "Spring Awakening" contains mature themes and is not suitable for all audiences.
Bloody, Bloody Andrew Jackson
University of California, Irvine
Claire Trevor Theatre
4002 Mesa Road
Irvine, CA 92697
(949) 824-2787
Nov. 9 to 17
There's a side to the United States' seventh president of which you may not be aware. Founder, patriot and shaper of American culture, absolutely, but do you know Andrew Jackson was also a rock star with a sense of humor? The University of California at Irvine Drama Department brings you the whole story in its season-opening politically timely production. A tale of the power of populism, "Bloody, Bloody Andrew Jackson" contains adult content and is not suitable for all audiences.
A Christmas Carol
University of California, Irvine
Winifred Smith Hall
710 University Drive, Building 710
Irvine, CA 92697
(949) 824-2787
Nov. 23 to 30 and Dec. 1
Another familiar story from your required reading takes life at UCI's Winfred Smith Hall. Kick off the season with the Dickens classic that is as much a part of the holidays as cranberry sauce and credit card bills. Crown jewel of the UCI Drama Department, director and choreographer Annie Loui captures the true drama and sentiment of Dickens' original work, which doesn't quite come through in the Disney version (no offense).
The Diary of Anne Frank
Fullerton College
Bronwyn Dodson Theatre
321 E. Chapman Ave.
Fullerton, CA 92832
(714) 992-7150
Dec. 5 to 7
You read it in school and now experience the heart-wrenching drama on purpose as an adult. The love, sacrifice and horror detailed by "Anne Frank" has been masterfully captured by Frances Goodrich and Albert Hackett in the original stage production. Feel the passion and lose yourself in the emotional journey as director Chuck Ketter brings Wendy Kesselman's stirring new adaptation, including first-hand survivor accounts, to the Bronwyn.
Christopher Schmidt is a freelance writer experiencing and espousing the glory that is Orange County. Driven to travel, drawn to sports, spirits and celebrity, Chris' work can be found on


text:
Legal Status
Document Details
Published Document
Internal Revenue Service (IRS), Treasury.
Notice and request for comments.
The Department of the Treasury, as part of its continuing effort to reduce paperwork and respondent burden, invites the general public and other Federal agencies to take this opportunity to comment on proposed and/or continuing information collections, as required by the Paperwork Reduction Act of 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning an existing notice of proposed rulemaking and temporary regulation, REG-251985-96 (TD 8786), Source of Income From Sales of Inventory Partly From Sources Within a Possession of the United State; Also, Source of Income Derived From Certain Purchases From a Corporation Electing Section 936 (§ 1.863-3).
Written comments should be received on or before July 18, 2006 to be assured of consideration.
Direct all written comments to Glenn Kirkland, Internal Revenue Service, room 6516, 1111 Constitution Avenue, NW., Washington, DC 20224.Start Further Info
Requests for additional information or copies of the regulations should be directed to Larnice Mack at Internal Revenue Service, room 6512, 1111 Constitution Avenue, NW., Washington, DC 20224, or at (202) 622-3179, or through the Internet at (firstname.lastname@example.com).End Further Info End Preamble Start Supplemental Information
Title: Source of Income From Sales of Inventory Partly From Sources Within a Possession of the United States; Also, Source of Income Derived From Certain Purchases From a Corporation Electing Section 936.
OMB Number: 1545-1556.
Regulation Project Number: REG-251985-96.
Abstract: Section 1.863-3(f)(6) of this regulation requires taxpayers to attach a statement to their tax return furnishing certain information regarding the methodology used to determine the source of their income from cross-border sales of inventory, and the amount of income allocated or apportioned to U.S. or foreign sources in these sales. The information is used by the IRS to establish whether the taxpayer determined the source of its income in accordance with Code section 863.
Current Actions: There is no change to this existing regulation.
Type of Review: Extension of a currently approved collection.
Affected Public: Business or other for-profit organizations.
Estimated Time Per Respondents: 200.
Estimated Time Per Respondent: 2 hours., 30 minutes.
Estimated Total Annual Burden Hours: 500.
The following paragraph applies to all of the collections of information covered by this notice:
An agency may not conduct or sponsor, and a person is not required to respond to, a collection of information unless the collection of information displays a valid OMB control number. Books or records relating to a collection of information must be retained as long as their contents may become material in the administration of any internal revenue law. Generally, tax returns and tax return information are confidential, as required by 26 U.S.C. 6103.
Request for Comments: Comments submitted in response to this notice will be summarized and/or included in the request for OMB approval. All comments will become a matter of public record. Comments are invited on: (a) Whether the collection of information is necessary for the proper performance of the functions of the agency, including whether the information shall have practical utility; (b) the accuracy of the agency's estimate of the burden of the collection of information; (c) ways to enhance the quality, utility, and clarity of the information to be collected; (d) ways to minimize the burden of the collection of information on respondents, including through the use of automated collection techniques or other forms of information technology; and (e) estimates of capital or start-up costs and costs of operation, maintenance, and purchase of services to provide information.Start Signature
Glenn Kirkland,
IRS Reports Clearance Officer.
[FR Doc. E6-7621 Filed 5-18-06; 8:45 am]