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Harvard Business School Ranked as the No. 1 MBA Program for the third consecutive year in this year's 2015 FT survey released on 26th Jan 2015. This is the 6th time that FT has named HBS as the world's best MBA program since it started publishing the best MBA programs ranking report. PoetsandQuants came up with an amazing […]
Harvard Business School Ranked as the No. 1 MBA Program for the third consecutive year
Indian Institute of Management, Bangalore (IIMB) named as the best B-School in Central Asia for the seventh consecutive year
Indian Institute of Management, Bangalore (IIMB) maintained its place of the best B-School in Central Asia for the seventh consecutive year. Eduniversal, a ranking and rating agency specialized in higher education announced the award at it's The Worldwide Business Schools Rankings for 2014 Gala Dinner and Award Ceremony in Istanbul in October. The title of […]
Smart Ways to Research about MBA Schools before Selecting the Best One
Smart Ways to Research about MBA Schools before Selecting the Best One It is not uncommon for several young professionals to think about joining a business school for acquiring the degree of Master of Business Administration (MBA). While a solid economy encourages several professionals to carry on with their current roles, the dream of working at […]
Can I do my masters with 15 years of Education?
"Can I do my masters with 15 years of Education?" "Can I go to USA with 15 years of Education?" "Which countries can I do my post graduation with 15 years of Education?" These are some of the most commonly asked questions by starry-eyed students to a Foreign Education Consultant. The ' I have completed […]
Maximize Your MBA Application: 5 Tips for Succinct Essays
Photo credits: SFU Public Affairs and Media Relations If you're working on your MBA application, you're in luck. We have five super simple (and powerful) tips that will help you come up with a succinct essay that will win people over. Getting into business school isn't easy these days with so many people trying to […]
Did You Miss Out On The First Round Of Applications For MBA Admissions?
Most business schools, especially the ones in the US, have around 2-3 rounds of applications submission. This is primarily to reduce the load of applications they receive. The first round generally ends in late September to early October, the second round in early January and the final round in early April. These are rounds of […]
Chicago, University of – Booth School of Business Ranked Best B-School in the world by The Economist MBA Ranking 2013
The Economist ranks Chicago, University of – Booth School of Business United States as the No.1 B-school in the world in its MBA rankings 2013. Booth School of Business was ranked as the top b-school by the British magazine even in the year 2012. The Economist has ranked Chicago Booth as the world's best business […]
IIMA breaks into the top 40 B-schools list globally for the first time
IIMA breaks into the top 40 B-schools list globally for the first time in The Economist MBA Ranking 2013 October 14, 2013: The Indian Institute of Management, Ahmedabad (IIMA) has been ranked 39th globally in The Economist full-time MBA programmes ranking 2013, moving up from 56th position last year, in the top 100 B-schools list. Moving […]
In Conversation with Chen Shimin – Director of MBA Admissions at CEIBS : China Europe International Business School
CEIBS : China Europe International Business School 中欧国际工商学院; or 中歐國際工商學院 is a renowned business school business school in mainland China which was the first to offer a full-time MBA, an Executive MBA and a wide range of Executive Development programs. Its ranked in the world's Top 30 by the Financial Times. CEIBS degree programs are a unique and innovative […]
Ross – Best B-school for entrepreneurship 2013 says Princeton survey
Earlier in 2011 we had written about the Best B-Schools for Entrepreneurs and The F.W. Olin Graduate School of Business at Babson College in Massachusetts offered the number one graduate business program for entrepreneurs in the country, according to the U.S. News and World Report website, as of 2011. A recent survey ( September 19th 2013 ) done […]
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Cosmos Architecture Meeting 31-July-08
These are the minutes for the Architecture Meeting for 31 July 2008.
- David
- Jason
- Srinivas
- Jimmy (definitely not lurking)
- JT (lurking)
- Hubert
- Ali
- Leonard
- Jack
- Status update on i12 candidate build
- All P1 and P2 enhancements complete
- No P1 or P2 defects and 100% test attempt. Any exceptions require Community discussion and PMC sign-off.
- Test results posted; All exceptions reviewed before deferral/discharge
- QA on target and should complete testing by next Wednesday. TODO: Team leads need to ensure Bugzilla is up to date for i13.
- Martin: missing a MDR for the demo that includes security and uses a different SOAP version. Could create example MDR that requires security and SOAP 1.1. Could build on that later to add extra security stuff. QA might be doing limited testing, but not real testing of security without this. TODO: Martin to create ER for this.
- TODO: David to follow up with Ruth on summit and deadline for designs. Once this is decided, designs need to be created and ERs added to i13 plan page.
- Jimmy asked if we needed more SML tooling testing. David said the non UI stuff is well covered, but suggested that we can use some help in implementing bugzilla 175382, which would also help our QA coverage and would allow someone to get exposure to the SML tooling. TODO: others (QA?) to consider helping on this.
- Martin asked Hubert about the translation of CMDBf queries to SQL investigation. Hubert says we haven't done anything with it, and hasn't gotten any feedback on the information he presented. Martin mentioned that there are CMDBf queries that can't be represented in SQL, and said it would be nice to be able to warn the user about those cases. Martin proposed to extend the query builder to support the building of CMDBf query given the use of relational database and the use of SQL. Hubert suggested the a translator between SQL and CMDBf query is possible. Hubert also commented on the use of the query builder that CMDBf query syntax should not be exposed in the UI. We need predefined queries to be able to accept parameters and form the query dynamically.
- The feeling is that this should be very high on our list of post COSMOS 1.0. TODO: David to create wiki page to capture our post COSMOS 1.0 priorities.
- David mentioned the need for a simplified query builder that handles the common cases, so the end user doesn't require a full knowledge of CMDBf's model for ad-hoc queries. Discussed offline with Sheldon, and he agreed. TODO: Sheldon to create ER for doing this post-1.0.

subset: commoncrawl


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About the CELBAN Test
CELBAN is one of two tests accepted by nursing licensing bodies across Canada as evidence of language proficiency for licensure. If you completed your nursing education in another country and English is a second or additional language for you, you may consider taking the CELBAN.
CELBAN is a task-based evaluation of those four communication skills. This means that you are tested on your ability to use the English language to accomplish communication tasks.
Examples of communication tasks:
Giving instructions to a patient
Completing a form
CELBAN scores align with the Canadian Language Benchmarks (CLB), a descriptive scale of communicative proficiency in English as a second language.
Benefits of CELBAN
The CELBAN provides a realistic measure of the language skills required to work as a nurse in a Canadian workplace. Unlike other language assessments, CELBAN tasks are occupation specific. Nurses are assessed on their communication skills using tasks that are familiar to nursing practice. These include:
Giving instructions
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Along with their test scores, candidates receive feedback on their strengths and weaknesses so they know what areas they need to work on.
CELBAN and Institutional CELBAN were developed by and are products of the
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Styal Under 21's 2015/2016 start their first season
The 2016 Festival is scheduled for Friday 15 and Saturday 16th July.
This year will see a new stage set up and a great band line up. Pricing as last year. Go to www.styalbeerfestival.co.uk and buy your tickets in advance. As in recent years Saturday tickets will not be availble on the night.
18th December 2015
We are saddened to announce that Alan Jones has passed away. He died peacefully at home.
There is no one that has done more than Alan Jones for Styal FC. During more than 50 years he has ensured the clubs stability. Needless to say his contribution will never be forgotten and everyone will miss him.
The date for the funeral is Monday 11th January. The service is at 10.00am at Styal Methodist Church which is just across from the clubhouse at Styal. This is followed by 11.20 at Macclesfield Crematorium for any that wish to attend this.
The football club will provide a buffet and will be open after the church service for those coming back from the Church and also the crematorium later. We extend a warm welcome to all Alan's footballing friends and family.
Funeral donations can be made to The Alzheimers Society
Training is at the following address Tuesday and Thursday 6.45
Thanks to all those that supported the 2015 Styal Beer Festival held 17 and 18th July. It was another resounding success. Money was again raised for charities, excellent music from various bands enhanced by new stage and lighting set up. Debut appearance by Styal Schools steel band went down extremely well. Biggest thanks goes to the volunteers as their massive efforts backing the football club make this event happen, but all the community support we receive in different forms is invaluable and highly appreciated
Styal Football Club are pleased to announce the pre-season training arrangements and details ahead of our upcoming season and our quest to become champions in the Mid-Cheshire Hallmark Premiere and Reserve Division 1 1st Team managers Kevin Kinsella and Nick Murray are pleased to announce the following statement.
Pre season will commence on Tuesday June 23rd at 7pm to 8.30pm at Styal FC's home ground, Altrincham Road. Our training nights are Tuesday's and Thursday's until further notice. All players are expected to attend all training sessions. We ask that players arrive at training at no later than 6.45pm. Any players wishing to trial for Styal Football Club are welcome to do so.
This season we are approaching everything we do with a great deal of professionalism, both on match days and at training. Bearing that in mind the Styal training sessions will consist of a full fitness programme, led by an outside professional. We are pleased to announce that both the 1st and reserve team will receive training from a UEFA licensed coach.
For our upcoming campaign we would like to reiterate that we are looking to compete at the highest level in this league. We are keen for players to develop both independently and as a team and we are confident that movement within the squad will be of benefit to us.
We would like to invite any players wishing to trial for Styal Football Club to attend our first training session. Please arrive no later than 6.45PM. If you have any questions or would like to discuss this further please do not hesitate to contact us on one of the following numbers. Please bring running shoes and boots to training. We are looking to accept players over the age of 16. 07875024191 Kevin 07914024215 Nick.


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With a stay at Hotel Zenit Vigo in Vigo, you'll be a 4-minute drive from Museum of Contemporary Art and 8 minutes from Castro Fortress. This 4-star hotel is 0.1 mi (0.2 km) from Sargadelos Gallery and 0.4 mi (0.6 km) from Centro Principe.
Make yourself at home in one of the 92 air-conditioned rooms featuring minibars and plasma televisions. Complimentary wireless Internet access keeps you connected, and cable programming is available for your entertainment. Private bathrooms with showers feature complimentary toiletries and hair dryers. Conveniences include phones, as well as safes and desks.
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For lunch or dinner, stop by DAqui Vigo, a restaurant that specializes in regional cuisine. Dining is also available at the coffee shop/café, and room service (during limited hours) is provided. Wrap up your day with a drink at the bar/lounge. Buffet breakfasts are available daily from 7 AM to 10:30 AM for a fee.
Business, Other Amenities
Featured amenities include a business center, complimentary newspapers in the lobby, and dry cleaning/laundry services.


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Conspiring with Inanna authors
Join four great Inanna authors for the launch of four great books! Pam Galloway, author of Passing Stranger (a book of poems), Susan McCaslin, author of Into the Mystic: My Years with Olga (a memoir in poetic prose), Ursula Pflug, author of Motion Sickness (flash fiction, graphic novel) and Phyllis Rudin, author of Evie, The Baby, and the Wife (a novel).
About Inanna Publications : Inanna aims to conserve a publishing space dedicated to feminist voices that provoke discussion, advance feminist thought, and speak to our diverse lives. Founded in 1978, and housed at York University since 1984, Inanna is one of the very few autonomous feminist presses in Canada. It is also the proud publisher of one of Canada's oldest feminist journals, "Canadian Woman Studies/les cahiers de la femme."
Refreshments will be served. Free!


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Dear Truth or Dare Pics,
My wife and I have recently found your site, and we really, really enjoy it. We have an absolutely amazing sex life and love to continuously push our limits. We are always up for trying anything new and adventurous. Some of our more risque sexual experiences have included sex in lots of exciting places, anal sex, and even some threesomes. We have taken pictures of ourselves before, but until now my wife has never been up for letting anyone else see them. Well, she has agreed to try it for my birthday because she knows how much it is going to turn me on, so we have included some pictures of her for our first post. I know that she will get some really good feedback from everyone, and that will make her want to post more pics. We have made a list of dares for her (or us) to do for future pictures, but we would love to get some more ideas from other people. We are really looking forward to receiving a lot of e-mails with dare ideas, picture requests, and feedback on what you think of my wife. We would also love to look at any pictures that any other couples want to send us.
This first set of pictures that we are posting includes 2 dares that she has completed for me. One set of them involves her sitting nude in front of the computer looking at your website. The other set is from our most recent adventure; the movie theater. We arrived early at a recent movie and decided to have some fun. My wife wore a skirt with no panties on underneath, since she knows what that does to me. The risque pictures that you see here led to me going down on her before the movie began. I had to stop when people began arriving, but we were able play with each other through most of the movie, and then we had an amazing night of sex when we got back home.
We always have the most amazing sex after all of our risque adventures. Some of the best sex we have ever had came right after we played truth or dare or had a threesome. Most of the foreplay in our threesomes comes from playing truth or dare. Right now we are looking for a really fun couple that we can play truth or dare with and possibly experiment with some "light" swinging.
I can't wait to see our pics on your website, and we look forward to receiving a lot of feedback.
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text: "Got a light? You've written your screenplay, but how are you going to make it look good?" Adult film producer Shine Louise Houston shares her an introduction to lighting, including how to light a production with cheap and free items. Additional Resources: How to Videos Articles Newsletters (with casting calls and festival submissions) International Adult Film […]Tags: adult film, Crash Course, diy lighting, film lighting, how to light a porn, and lighting. Performers: Jiz Lee and Shine Louise Houston.


text:
Looking for accommodation for March / April (Chennai)
Hi all
I will be moving to Chennai on 27 Feb and there for March / April. Work have said that I may be able to live in a small room in the office but wanted to see if there were any other options out there Protected content 7 office doesn't sound great)!
The office is based in Ayanavaram, so somewhere not to far away. Up for sharing with flatmates or reasonable hotel / other, any suggestions welcome.


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Oil and Gas Industry
Burden of the Boom: Who Will Pay the Price for Fracking in California?
By Miriam Rotkin-Ellman
Natural Resources Defense Council
From polluted skies to contaminated drinking water and hazardous waste, communities of color in California get way more than their fair share. If the oil and gas industry gets their way, drilling – and the environmental and health threats from fracking, acidizing, and other technologies – will be piled onto communities already staggering under smoggy skies and unsafe water.
Massive Dumping of Wastewater Into Aquifers Shows Big Oil's Power in California
By Dan Bacher
As the oil industry spent record amounts on lobbying in Sacramento and made record profits, documents obtained by the Center for Biological Diversity reveal that almost 3 billion gallons of oil industry wastewater were illegally dumped into Central California aquifers that supply drinking water and irrigation water for farms.
The Center said the wastewater entered the aquifers through at least nine injection disposal wells used by the oil industry to dispose of waste contaminated with fracking (hydraulic fracturing) fluids and other pollutants.
Big Oil Spokesman Admits Water Use Will Rise with Expanded Fracking
By Dan Bacher
Oil and gas industry representatives constantly like to talk about the "small amounts" of water that the industry currently uses in fracking operations in Kern County and coastal areas of California.
However, on April 28, Tupper Hull, spokesman for the Western States Petroleum Association (WSPA) and former press spokesman for the Westlands Water District, admitted in an interview on National Public Radio (NPR) what the anti-fracking community has known for a long time: Once they figure out how to make the Monterey Shale economically viable, the water usage will ramp up significantly.
Here is a partial transcript of Lauren Sommer's interview with Hull, courtesy of the Stop Fracking California State Facebook page:
Fracking Moratorium Bill Passes Senate Environmental Quality Committee
By Dan Bacher
A bill imposing a moratorium on fracking and acidizing for oil extraction in California passed through the Senate Environmental Quality Committee Wednesday by a 4 to 2 vote.
Senators Mark Leno, Jerry Hill, Loni Hancock and Fran Pavley voted for Senate Bill 1132, while Senators Ted Gaines and Jean Fuller voted against it. Senator Hannah-Beth Jackson was out of the room for the initial vote, but is expected to vote in favor of the bill.
Authored by Senators Holly Mitchell and Mark Leno, SB 1132 would require the Natural Resources Agency to facilitate an "independent scientific study" on well stimulation treatments (fracking and acidizing) and their hazards and risks to natural resources and public, occupational, and environmental health and safety by January 1, 2015.
Senate Committee Approves Fracking Moratorium Bill
By Dan Bacher
The California Senate Committee on Natural Resources and Water on April 8 passed SB 1132, legislation that will place a moratorium on fracking (hydraulic fracturing) and well stimulation until the state fully studies the impact of the oil extraction on California's air and water quality, public health and economy.
The bill, authored by Senator Holly Mitchell and Senator Mark Leno, will next be considered by the Senate Environmental Quality Committee on April 30, 2014.
California Officials Concerned Over Oil and Rail Industry Secrecy
By Diane Bailey
Natural Resources Defense Council
One thing about these industries - when the oil and rail barons get together, tidy profits are sure to be made. But at whose expense? And if the latest mile long oil by rail collaboration has nothing to hide, why won't they tell the public what is in the rail tanker cars, where they're going and how often they'll be passing through town?
State Senators Mitchell and Leno Introduce Fracking Moratorium Bill
By Dan Bacher
State Senators Holly Mitchell (D-Los Angeles) and Mark Leno (D-San Francisco) have introduced legislation that would impose a moratorium on fracking and acidization in order to protect California's air and water from pollution caused by this dangerous form of oil and gas extraction.
The bill was introduced as California reels from a record drought and Governor Jerry Brown continues to support the expansion of fracking in California and the construction of the fish-killing peripheral tunnels under the Bay Delta Conservation Plan (BDCP).
New Study Finds Worrisome Pattern of Birth Defects in Fracking Communities
By Miriam Rotkin-Ellman
Natural Resouces Defense Council
Science has long known that the developing fetus is sensitive to experiences of the mother – alcohol consumption, dietary factors, and mercury exposure are some of the more well-known examples. This sensitivity makes newborn babies an early indicator of something going wrong in the environment of the mother. Unfortunately, a team of researchers found preliminary evidence of something gone wrong when they looked at the patterns of birth defects in newborn babies in Colorado. The researchers found that babies whose mothers lived in close proximity to multiple oil and gas wells were 30% more likely to be born with defects in their heart than babies born to mothers who did not live close to oil and gas wells.
An Alternative to Fracking & California's Drought Emergency
By Giulia C.S. Good Stefani
California is home to the popular-for-rafting Kern River, Big Sur sunsets, the endangered blunt-nosed leopard lizard, some of the world's most important blue whale foraging habitat, strawberry valleys, rolling farms, cowboy towns, and big bustling cities. All of this is put at risk from the heavy industrial oil and gas extraction process called fracking.
California Legislators Call for Fracking Moratorium
By Dan Bacher
On January 7 nine California legislators sent a letter to Governor Jerry Brown asking that he issue an executive order to prohibit the Division of Oil, Gas, and Geothermal Resources (DOGGR) within the Department of Conservation from allowing fracking in the state until health and environmental concerns are addressed.


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Q. Who can register?
A.Anyone who is an Indian citizen, residing in India, of 18 years or above as on May 25, 2012 and the citizen should be of sound health and mind can register for KBC. No person can participate on behalf of another person.
Q.When will the lines be open for registration?
A.Registration lines (both IVRS – phone and SMS - messaging) are open from 21:00:00 hrs on May 28, 2012, when the first question goes on air, till 20:59:59 hrs on June 7, 2012, for all viewers. The schedule of on-air registration questions during this period will be as below:
A.You can register by answering the on-air question through an SMS or by calling on the IVR number. The registration details of the numbers to be dialled for IVR and short code for sending SMS with the answer options are listed below:
Q. In which format do I have to send the SMS?
A.All registration through SMSs need to be in the following format:
"KBC <space>< Answer Option (A/B/C/D)> <space><Age in completed years> <space><Gender>". e.g.: If the correct answer to the question aired is "A" according to you, you are 21 years and 10 months old as on 25th May, 2012 and are a male; you are required to send "KBC A 21 M".
During the telecom partner week, the subscribers of the telecom partner are required to send SMSs in the following format:
"KBC <space>< Answer Option (A/B/C/D)>"
e.g.: If the correct answer to the question aired is "A" according to you, you are required to send "KBC A"
Q.What will it cost me to call or send an SMS?
A.SMS : Every SMS sent to the registration numbers will be charged as per the premium rates charged by the telecom operators.
SMS's sent in the wrong format or with the incorrect answer are also chargeable.
Premium rates apply. Please check with your telecom operators for more details.
*Available only on select operators. Terms & Conditions on www.kbcsony.com
* Roaming charges will be levied by your operator as applicable
IVR : All calls made to the registration numbers will be charged as per the premium rates charged by the telecom operators..Premium rates apply. Please check with your telecom operators for more details.
However, we recommend that you contact your service provider for further details on the same.
* Roaming charges will be levied by your operator as applicable
Q.Can I send more than one SMS / make more than one call?
A.Yes, there is no restriction on the number of SMSs sent or calls made to register for the auditions. However, there is no weightage given to number of calls made / SMSs sent at the time of shortlisting for auditions. The final selection is made on a random basis from amongst all valid and correct registrations received and if a person has been selected once, he is not eligible to be selected again in the same audition shortlist.
Q.When will I know the result of the registration?
A.If the answer provided by you was both valid and correct and you were selected in the random shortlist, you will receive a call from us in around five (5) working days from the date of close of registration lines for that question.
Q.How will I know if I am shortlisted for the next round?
A.If the answer provided by you was both valid and correct and you were selected in the random shortlist, we will get in touch with you on your registered number please answer the phone yourself.
Q.Where and when will the auditions be conducted?
A.The auditions will be held at the following locations as per the defined schedule:
Q.Can I choose my preferred location for audition?
A.No. You will not be able to choose location for auditions, a location chosen by Multi Service Media Pvt Ltd. will be offered to all shortlisted Registrants. If the short-listed Registrant chooses to decline the same, he renounces further participation in KBC.
Q.What if I am unable to make it for the auditions?
A.Inability to attend the auditions on the specified date, time and location will close and/or terminate further participation in KBC.
Q.What will I be required to do at the auditions?
A.Each auditionee will be made to go through two pre- defined audition rounds.
The first round will involve answering skill- based questions, the second round will be a video round where the Auditionee will have to give a personal interview.
Q.Will I have to bear all expenses in order to be present for the audition round?
A.Yes, all expenses directly or indirectly connected with being present for the auditions (travel, conveyance, lodging, stay, meals, etc.) will be borne by the Auditionee.
Q.How will I know the result of the audition round?
A.The Auditionees that are shortlisted on the basis of the audition round will get a call from Multi Screen Media Pvt. Ltd. through its producers informing them of selection in the Fastest Finger First round of the show.
Q.What documents will I require to carry for the auditions?
A.Proof of identity, age and address will be accepted in English or Hindi only.
Valid name proofs that will be admissible are:
1. Birth certificate, 2. Passport, 3. Voter ID, 4. Driver's License, 5. PAN card, 6. UID / Aadhar card.
Valid address proofs that will be admissible are:
1. Phone / Electricity Bill , 2. Passport, 3. Voter ID, 4. Driver's License, 5. Ration card, 6. UID / Aadhar card.
Q. What are the selection criteria?
A. The main criteria for selection is your general knowledge and grasp over current affairs, which is evaluated across various stages. In addition, there is also an interview round and audition at the final stage where your personality and screen presence are also evaluated.
Q. I have a query. Whom can I ask?
A. Please send your queries to email@example.com and we will try to revert as soon as we can. Alternately, you can refer to our terms and conditions on www.kbcsony.com
Q.Where can I read detailed terms and conditions governing KBC?
A.The detailed terms and conditions governing the game show are available on www.kbcsony.com
Q.How many times can I participate?
A.Each registrant can be shortlisted only once for an audition in one schedule of registrations. However, there is no restriction on the number of times a viewer can SMS/ call to register.
Q.What is the Prize Money?
A.The person who gets on the hot seat and gets all the questions right will win upto INR 5 crore . The prize amount will be subject to tax as per government rules.
Q.Some people claim that they can help get entry to KBC. Is it possible?
A.The only way to enter KBC is through participation in the registration process as described in Rules and Regulations. There is no other way of entering KBC. This entire process is transparent and monitored by an independent Firm. Any person claiming that he/she can help get you on the show for a consideration is defrauding you. Please contact your local police and report this person.
Q.I got a call after answering the question asked on TV, but no one has called me after that. Have I been selected?
A.The call you received was because you were among the short-listed registrants selected by the randomizer. However, this does not mean that you have been selected. We will be contacting the successful candidates who have made it to the next round.
Q.What is the basis of selection of the final auditionees?
A.Following grid will be used for selection of final auditionees.
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text: Well like most of you I can't read japanese. Do any of you know the symbols for each nature? I want to reroll for a decent nature. I know there won't be pokesav for this gen for awhile so I want to have at least one well bred starter. This thread is for people who actually care about their breeds and not just filler pokemon.


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Kogan.com for Charities
As a charity, you'll be well aware that the money you do spend needs to be spent the right way.
Buying with Kogan.com means not only saving money on the items you buy, but no need for storage space or distribution solutions. We can send items directly to the recipient on your behalf, without anyone feeling embarrassment because it arrives like a normal delivery from a well-established national company.
Procurement made simple
By getting in touch with Kogan for Business, you can take control of purchases that would normally be considered as petty cash, increase accountability, as well as saving time and money on administration by having the choice of either single or consolidated monthly reporting. With most items dispatched within 1-2 working days, you can't go wrong.
We save you money and serve you right
As you may have guessed, plenty of businesses have already discovered Kogan.com can help save money on a huge range of items to furnish and equip their premises- or even save on holidays and travel.
If you want to buy better, and are struggling with budget confines, you'll find Kogan for Business can really make a difference.
Dedicated Kogan for Business team
Need help and need it fast? Contact us for dedicated service from an experienced team based here in Australia.
Contact us now to find out more about what we can do for you, contact us today.


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California's governor signed Assembly Bill 2833, enacting provisions that are intended to increase the transparency of fees paid by public investment funds to alternative investment vehicles. Under the new law:
The new disclosure requirements are effective for all new contracts a public investment fund enters into on or after January 1, 2017, and to all existing contracts in which the fund makes a new capital commitment on or after January 1, 2017.
Public investment funds are to require that each alternative investment vehicle in which it invests make the following disclosures at least annually:
A public investment fund is required to disclose the information provided to it by the alternative investment vehicle at least once annually in a report presented at a meeting open to the public. The report must include the gross and net rate of return of each alternative investment vehicle, since its inception, in which the public investment fund participates. The public investment fund may report the gross and net rate of return and information based on its own calculations or based on calculations provided by the alternative investment vehicle.
Read a September 2016 report [PDF 162 KB] prepared by KPMG LLP.
For more information, contact a tax professional with KPMG's State and Local Tax practice
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© 2018 KPMG LLP, a Delaware limited liability partnership and the U.S. member firm of the KPMG network of independent member firms affiliated with KPMG International Cooperative ("KPMG International"), a Swiss entity. All rights reserved.
The KPMG logo and name are trademarks of KPMG International. KPMG International is a Swiss cooperative that serves as a coordinating entity for a network of independent member firms. KPMG International provides no audit or other client services. Such services are provided solely by member firms in their respective geographic areas. KPMG International and its member firms are legally distinct and separate entities. They are not and nothing contained herein shall be construed to place these entities in the relationship of parents, subsidiaries, agents, partners, or joint venturers. No member firm has any authority (actual, apparent, implied or otherwise) to obligate or bind KPMG International or any member firm in any manner whatsoever. The information contained in herein is of a general nature and is not intended to address the circumstances of any particular individual or entity. Although we endeavor to provide accurate and timely information, there can be no guarantee that such information is accurate as of the date it is received or that it will continue to be accurate in the future. No one should act on such information without appropriate professional advice after a thorough examination of the particular situation. For more information, contact KPMG's Federal Tax Legislative and Regulatory Services Group at: + 1 202 533 4366, 1801 K Street NW, Washington, DC 20006.


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Welcome to The Sweet Scent of Home
Thank you for visiting The Sweet Scent of Home.
We are a Home Fragrance retailer based in Stockport and we believe above all, in quality.
Through the continual supply of high quality products, we aim to build long and trusting relationships with our customers. We will never compromise our quality over price, yet we aim to offer our products at honest and fair prices to everybody.
If you require any advice or assistance in purchasing any home fragrance product please feel free to telephone us on 07515 735486 (Monday to Friday 9am-5.00pm) and we will be happy to help you.
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Ascension Island
Ascension Island is an isolated volcanic island in the equatorial waters of the South Atlantic Ocean, around a thousand miles from the coast of Africa and 1400 miles from the coast of South America, which is roughly midway between the horn of South America and Africa. It is governed as part of the British Overseas Territory of Saint Helena, Ascension and Tristan da Cunha, of which the main island, Saint Helena, is around eight hundred miles to the southeast. The territory also includes the remotest populated archipelago on earth, the sparsely populated Tristan da Cunha archipelago, some thirty degrees farther south and about half the way to the Antarctic Circle.
It is primarily a military base, but access has recently improved and the island makes a fascinating destination for seabird enthusiasts. Ascension is a relatively young island of volcanic origin with a hot and usually very dry climate. These conditions have resulted in its flora and fauna being much less diverse than on St Helena. Only some 25 indigenous land plants have been recorded. Ten of these were unique to the island, but four have become extinct. The endemic invertebrates number less than 30 and most of these are tiny inhabitants of crevices in the lava. Just two endemic land birds, the Ascension Rail Atlantisia elpenor and the Ascension Night Heron Nycticorax sp. are known to have existed on Ascension and both are now extinct. Ascension did not have indigenous land mammals, reptiles or amphibians, although the island is an important nesting site for Green Turtles Chelonia midas.
Ascension is, however, a major breeding site for seabirds. The lava plains of the main island and cliffs originally held huge colonies of terns, boobies, frigates, noddies and tropicbirds. Since human colonisation things declined.
Introduced alien species, particularly cats and rats, have had a serious effect on the native wildlife. The seabirds have been particularly badly affected, with most of the larger species deserting the main island to nest on the predator-free stack of Boatswainbird Island, now the only breeding site of the Ascension Frigatebird and with a tiny relict population of Red-footed Boobies. Sooty Terns still maintain large colonies on the main island, breeding at intervals of just over nine months rather than annually. Their numbers have been much reduced by cats but a cat eradication programme has been undertaken and is showing signs of success. Masked Boobies have bred again on the main island and it is hoped that frigatebirds and the other displaced species will also return. Attempts at more effective rat control are also being made.
Number of Species
Number of bird species: 90
African Bird Club
…Ascension is, however, a major breeding site for seabirds. The lava plains of the main island originally held huge colonies of Sooty Terns Sterna fuscata, Masked Boobies Sula dactylatra and the endemic Ascension Frigatebird Fregata aquila. Large numbers of Red-footed Sula sula and Brown Boobies S. leucogaster, Brown Anous stolidus and Black Noddies A. minutus, Fairy (White) Terns Gygis alba and both Red-billed Phaethon aethereus and White-tailed Tropicbirds P. lepturus nested in the sea cliffs and stacks. In contrast to the situation on St Helena, petrels were a relatively minor component of the recent seabird community on Ascension with only Audubon's Shearwater Puffinus lherminieri (now locally extinct) and Madeiran Storm-petrel Oceanodroma castro nesting there…
Trip Reports
CloudBirders was created by a group of Belgian world birding enthusiasts and went live on 21st of March 2013. They provide a large and growing database of birding trip reports, complemented with extensive search, voting and statistical features.


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Price: $429.00
Choose a local authorized Felt dealer.
Cruiser >
Men's Cruisers >
El Bandito 1-SP
Felt classic curved cantilever steel w/ carrier bosses
Unicrown steel, curved blades
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Felt aluminum 32mm wide rims, stainless steel spokes & cruiser style 26 x 2.125" tires
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Why Choose PTSM?
Our Mission
The Port Townsend School of Massage was born out of a strong desire to make a contribution to community through the massage profession. Our commitment is focused on recognizing, supporting and enriching each individual while providing a community oriented learning environment which fosters excellence in natural therapies. At PTSM we strive for excellence—one massage therapist at a time.
Our programs include three main areas of emphasis:
- The best traditional and innovative massage techniques
- An extensive holistic knowledge of the human body
- An embodiment of the highest professional integrity
Holistic Emphasis
Incorporated into the curriculum is information on natural solutions to health and wellness. We want to share with our students' information on body awareness and self-care strategies. PTSM aims to reach each individual, not only through teaching theory and technique, but also in improving and supporting each student's personal state of being.
Our Faculty
Our faculty is dedicated to PTSM and the success of each student. Many of our instructors are trained in multiple fields, lending additional insight to their instruction. The instructors have practiced in their respective fields and bring personal and direct experience from working with clients to their instruction.
Our Curriculum
PTSM graduates students who have achieved excellence in both academic and hands-on skills. Coursework is carefully selected to meet the requirements of the State of Washington; is offered in a logical and sequential manner, and offers our students state-of-the-art modalities for future success and employability.
Our Scheduling Options
Our Professional Licensing Programs allow our students to choose from two flexible formats; a Weekday Program or Weekend Program. These scheduling options help accommodate our students while working, allowing for family life, having enough time to accomplish everything required, and retain the material taught in class.
Our Location
The heritage and history of the Pacific Northwest is still honored in Port Townsend. The Native Americans respected this area as a place of growth, healing and transformation. The majestic mountains and calming waters, the recreational opportunities and the amazing sense of community surrounding Port Townsend draw many students to PTSM.
Our Reputation among Graduates, Peers, and Employers
Our graduates are highly respected. Through our programs they receive excellent skills training and in-depth practice with a variety of modalities. This strengthens our profession and helps our graduates obtain success quickly after completing our programs.
Our Tuition
Your investment in your education will provide you with excellent value. We have several possibilities for financial aid including payment plans, VA benefits under the GI Bill and Worksource Funding for those who are eligible.
Our Focus on Learning Style
Finding your individual learning style is an important part of acquiring the knowledge and skills necessary to becoming a licensed massage practitioner. Knowing the way you learn is just as important as what you learn. We will work with you to find your optimal learning style.
In addition, our classes are smaller than many Western WA massage therapy schools which allows us to pay close attention to your individual needs. This intimate atmosphere creates a wonderful learning environment where long, deep friendships can develop.


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The HTC First, or "Facebook phone" as many prefer to call it, is officially a flop. It certainly wasn't a good sign when AT&T dropped the price of HTC's First to $0.99 just one month after its debut, and now BGR has confirmed that HTC and Facebook's little experiment is nearing its end. BGR has learned from a trusted source that sales of the HTC First have been shockingly bad. So bad, in fact, that AT&T has already decided to discontinue the phone.
[More from BGR: Another reason for Facebook Home's rough start: The team behind it didn't fully understand Android]
Our source at AT&T has confirmed that the HTC First, which is the first smartphone to ship with Facebook Home pre-installed, will soon be discontinued and unsold inventory will be returned to HTC. How much unsold inventory is there? We don't have an exact figure, but things aren't looking good. According to our source, AT&T sold fewer than 15,000 units nationwide through last week when the phone's price was slashed to $0.99.
[More from BGR: Bill Gates recounts final visit with Steve Jobs in emotional interview [video]]
For some perspective, BGR has been informed that sales of the HTC First have been even worse than HTC Chacha sales were back in 2011, when AT&T launched the ill-fated phone as the Status.
BGR recently reviewed Facebook Home and found it to be a promising product in need of some serious tweaking.
We're told that AT&T sales representatives do not like Facebook Home or the First at all, and they are making little if any effort to sell the handset to customers. Right now iPhones and Samsung's Galaxy S4 are the biggest sellers at AT&T by a substantial margin, our source said.
It is unclear exactly when the First will be pulled from store shelves. AT&T's $0.99 sale is obviously intended to move as much inventory as possible, and then the phone will be discontinued as soon as HTC's in-store display contract expires. HTC has paid to reserve display space in AT&T's retail stores for a certain period of time and the phone cannot be pulled until that contract has run its course.
An HTC spokesman and a spokesperson from AT&T both declined to comment.
This article was originally published on BGR.com


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Holland Applied Technologies- An Overview
At Holland, we focus on Quality in everything we do. Check out our new Overview Video to see what Holland Quality means.
BPOG Best Practice Guidelines for Mitigating Risk used in Biopharmaceutical Manufacturing
Recently, BPOG (Biophorum Operations Group) has published a guide that relates to mitigating risk in bio manufacturing processes when using single use systems components. A key aspect of the risk mitigation strategy is to consider the potential for chemical entities to migrate from the single use component material into the drug product. Suppliers could aid drug manufacturers with their risk mitigation strategies by generating extractables data on their single use materials. Extractables are typically 'worst case' indicators of potential leachables and provide a drug manufacturer with useful information on how to approach future leachables studies.
Key definitions to understand are listed below:
Extractables chemical entities that are able to be extracted from a component of a process system into a solvent under controlled conditions which are usually more aggressive than the normal operating conditions
Leachable's chemical entities which come from single-use system components that migrate into the drug product during normal use. The single use system consumable qualification process must demonstrate that processing components do not impact the quality of the drug product.
It is important to understand that the product quality should be maintained throughout the drug product lifecycle to ensure that the attributes deemed important to the quality of the drug product are consistent with those evaluated during clinical studies.
One aspect detailed by BPOG and other industry bodies is how to perform risk evaluation. Risk evaluation is based on assessing the risk to patient safety, product impact manufacturing and regulatory approval. The regulations for drug manufacturers specifically detail that the equipment used in manufacturing of the drug substance shall be constructed so that the surfaces that contact the process material or drug product shall not be, reactive, additive or absorptive.
Risk assessment can be focused on either testing of every single use system component or by taking a risk-based approach where only critical single use system components are tested. The approach taken can be determined by considering the following key attributes
- Distance of the single use component to the final drug product or API
- Process temperature
- Process time
- Process fluid interaction
- Dilution effects
If you have additional questions about extractables, leachables, or any single use components, contact a Holland Sales Engineer today.
*A Special thanks to Sade Mokuolu @ WMFTG BioPure for her help in putting this blog together
What Sanitary Gasket Material Should I Use? Check out our Chemical Compatibility Guide!
With so many options available for elastomers it can be hard to make sure you are selecting the one best suited for your application. This post is going to go through a few key questions to point you in the right direction.
Let's start by asking a few important questions about your application:
- What temperature is your process running at?
- How are you cleaning your system?
- What are you trying to seal?
Once we figure out the answers to those questions, we can start by looking at the three most common elastomers used in the high purity process industry- FKM, Buna, and EPDM. We're going to leave PTFE out because it isn't an elastomer- it's a plastic.
FKM and EPDM are able to handle high temperatures well, and with an upper operating temperature of up to 400 degrees Fahrenheit they are the clear choice for high temperature applications. EPDM is great with steam, but does not mix well with oils. And FKM doesn't perform as hot at low temperatures, with a lower operating temp of only 5 degrees.
Accordingly, if you are planning on either SIP or CIP, you'll want to go with FKM or EPDM. SIP uses steam to heat the process line up to at least 250 degrees Fahrenheit, which will cause some strain on your elastomers. If you are going to be running steam frequently through the process line then FKM or EPDM are a good choice for you due to its resiliency against steam and its ability to tolerate the temperature.
For CIP applications, all three elastomers provide good resistance to both acidic and caustic solutions commonly used in CIP procedures although Buna does not tolerate concentrated acids very well.
Before installing a new component you should always make sure that it is chemically compatible with your process fluid. In general, FKM is fairly inert compared to both Buna and EPDM and is well suited to most applications. But a chemical compatibility chart is available here to check your specific application.
By selecting the proper elastomer you may be able to stretch out the time between replacements.When it is time to replace them or if you have any questions please contact a Holland Sales Engineer.
At Holland, we're no strangers to sanitary batching systems. One of the most common customer challenges we're asked to solve is a simple batching application. Our customers turn to Holland for a one stop, robust solution that is cost effective and quick to implement. Previous posts have focused on batching systems that are volume based solutions- systems that incorporate a flow meter to control a process. This post will instead focus on weight addition systems and the different system solutions available.
So let's say you have a recipe for a product you make all the time. A recipe is, by definition, a set of instructions for obtaining a desired outcome. Every recipe has a several ingredients. How we choose to add those ingredients to a receiving vessel is a critical question that must be addressed early in the process design. One way to do it is with a flow meter used to volumetrically measure each ingredient introduced. While this may work well if you only have one ingredient or may be just metering off from a bulk tank, a volumetric system does have its drawbacks. For one, accuracy is limited to accuracy of the flow meter used. In some cases, the meter used is a turbine meter. These can have accuracies that deviate as much as 5%.
Even if the accuracy of your flow meter is sufficient for your application, many recipes call for a mass of product to be added- pounds, kilograms, etc, NOT a volume. To do this, best practice would indicate that we take a direct weight NOT volumetric measurement. When using a volume to add mass, you depend on a density based conversion and depending on processing conditions, fluid density can vary. The only way to do take a direct mass measurement is with a Coriolis meter, which often run well into the tens of thousands of dollars, depending on line size. Can you imagine if you have multiple ingredients, necessitating multiple coriolis meters? You also can't pass solids or dry products through a flowmeter.
As an alternative to volume based batching systems, let's consider a weight based alternative. With a weight based system, we use either a floor scale or load cells to measure the weight of either the receiving or dispensing container (a future post will take a closer look at weight by addition vs. weight by loss systems).
For this post, we'll assume that the receiving vessel is on load cells. With the receiving vessel on load cells, we can add multiple ingredients, liquid or dry, while only measuring one process. This greatly reduces the instrumentation cost of a system. Using a controller, either a PLC or something even simpler, like a Mettler Toledo IND690, valves can be opened and closed, pumps start and stopped once volumes are added. Controllers like the IND690 allow for recipe programming and storage and also have a digital display with tare functions to allow for manual addition if need be.
At Holland, we're able to take you all the way through system development. We usually start by working with a client to either design and fabricate a batching vessel, or retrofit an existing vessel to accommodate load cells. We then help identify and install auxiliary equipment that is very important AFTER ingredients are batched in- components like mixers, RTDs, and tank outlet valves. Once we identify what you want to measure and how you want to measure it, we can start working on HOW we're going to add ingredients. This can be by Waukesha PD pump, Masterflex peristaltic pump, or Quattroflow Quaternary diaphragm pump. We can also supply the proper ITT diaphragm or Waukesha seat valve to control flow in. Once that is done, we can work with you to size and select an appropriate floor scale or load cells. Coupled with the right control system, we have a fully functioning batching system, capable of adding a variety of different ingredients and storing several different recipes. So if you have any questions about your next sanitary batching application, contact a Holland Sales Engineer today.
What are Weld Maps and Weld Logs?
If you haven't figured it out yet, at Holland Applied Technologies, we are in the sanitary component and custom systems market and cater exclusively to the high purity process industry. In the high purity process industry, specifically the biopharmaceutical industry, documentation requirements are a key distinguisher between people who play in the industry and those that live in it. One of the most critical processes our customers trust us with is welding of material to create the fluid transfer paths that carry their products. Weld inspection and logging has been and will always be a key part of any Quality Assurance program. But because of the requirements of the US Food and Drug Administration and guidelines outlined by the American Society of Mechanical Engineers Bioprocessing Equipment Standard (ASME BPE), the weld documentation our customers ask us to provide is even more extensive. This post will focus on proper weld documentation specifically weld logs and weld maps- what they are and what information they provide.
Let's start with the weld map. Weld maps are isometric drawings of the assembly to be welded showing the location with each weld, each weld having its own unique identifying number. They also contain a bill of material with the part number of each component used in making the assembly. After each weld is completed, it is labeled with a weld number (usually pin stamped on the part) that corresponds to a number on the isometric drawing of the part. When the isometric drawing is reviewed during validation, a third party can use the weld map to quickly identify where on the process piping the weld was performed and then refer to the weld log to ascertain the data discussed above.
Weld logs contain the data specific to each individual weld. Normally a weld log sheet would contain all of the welding information for the welds on a specific isometric drawing. At the top of any weld log, you'll usually find client specific project specific information, i.e. project number, job number, etc. You'll also find the drawing number of for the isometric drawing that the log matches up with. You'll also see a section for gas lot number of the Argonne gas used for the weld purge as well a block with the signature of the welder who is doing the work.
For our weld logs, the main body of the document has 9 columns for the weld to complete and 3 for the weld inspector. For each weld, the welding technician first enters the weld number, the date, what piece of welding equipment is being used and which weld procedure is being used. All of our welding personnel are qualified to specific ASME Section IX weld procedures. They then enter the heat number for each of the two components to be welded, the size of the tubes being welded and their own initials.
The rest of each line on the weld log is used by the weld inspector. Each weld is visually inspected by a qualified weld inspector using a boroscope to examine the weld ID. After inspection he completes the log for that individual weld as to whether it had been boroscoped, did it pass the visual boroscope examination, the inspectors' signature and the date.
Once this process is completed, these documents, as well as the corresponding material test reports of the components used in the assembly, become part of the turn over package that ships with the system. Properly executed, you now have a comprehensive package identifying each weld, who made the weld, what components went into the weld and the corresponding material certs for each one of the components.
As we wrap this blog up, let's not forget why all of this documentation is important. The systems we fabricate at Holland Applied Technologies are used by our customers to manufacture drug products we literally inject into our bodies. And before the drug ever gets made, the system used to make it needs to be validated. Governing bodies like the US Food and Drug administration use the data provided in these logs and maps to approve the manufacturer and manufacturing facility, protecting public health and giving consumers the peace of mind that the medicines they are taking are made on systems and in facilities that comply with current best practices. So if after reading this blog, you have any questions about high purity process welding or documentation requirements, contact a Holland Sales Engineer today.
What are the NEC Requirements for Conduit Fittings in Explosion Proof Applications?
At Holland, we encounter many electrical system design challenges. Between large biopharmaceutical and food modules, smaller sanitary process skids, pump carts with VFD's, etc., there are many chances to learn. Recently we had an interesting situation that required us to modify our design to meet a portion of the NEC standard for Hazardous Classified location equipment.
Section 500 of NFPA 70: National Electric Code defines the requirements for building equipment in Hazardous Locations. The standard is broken down into three "Classes"-Class 1 deals with flammable gases and liquids, Class 2 deals with combustible dusts, and Class 3 deals with ignitable fibers. For our purposes, we are concerned with Class 1. This classification defines (among many other things) the requirements for electrical enclosures (which must be explosion proof) as well as the conduit lines that carry electrical cables back to these enclosures.
The requirement of the standard is that all conduit lines must have a seal off located within 18 inches of the purged panel enclosure. Seal offs are (as there name implies) a barrier that is filled with a compound that "provides a seal against the passage of gas or vapors through the seal fitting", and therefore into the enclosure potentially leading to a dangerous situation. Further, the standard requires that only 25% of the cross sectional area of the sealed fitting can be used up by the conductor wiring. Note that this is significantly less that the 40% allowable area that can be used in all the other fittings in the conduit assembly.
In our case, we realized during field installation that although we met the general 40% requirement, we did not meet the more stringent requirement in the seal off. This situation presented a few options that we had to think through. The first option was to increase the size of the seal off. The standard allows for a larger trade size seal when required to meet this requirement. Unfortunately, Crous-Hinds (as well as Gibson and Calbrite) doesn't offer a seal off in stainless steel that is larger than 1 inch. There are other options for larger seal offs in other materials of construction (Robroy makes a PVS coated metal conduit (Plasti-Bond) in much larger sizes as well as EYX in galvanized iron), but the specification on this job required stainless steel.
Option two was to reduce the size of the cables. The initial choice was a 3 conductor + ground 18 gauge wire. There are some nice advantages to running multiple conductors, primarily being that it gives more flexibility down the road with device choices (think limit switches, more instrumentation, troubleshooting, etc.). However, in this case we needed to figure how to make this work. We opted to use a 2 conductor with 18 gauge wire, reducing the wire size by more than 30%. This choice met the requirement for cross sectional area of the seal off, effectively getting us in "just under the wire" (ok, I have been waiting to use that) to meet the standard.
Electrical design is a big part of our work at Holland. Hopefully this post will give you some ideas if you run into issues with seal offs and related Class 1 work. Contact one of our Holland Sales Engineers a call if we can help you with a project you are working on.
Product Focus- Aseptiquik DC and Aseptiquik STC
For today's blog post, we're going to take a look at one of the product lines we saw great growth in 2016- Colder's line of Aseptic Connectors, Aseptiquik. Specifically, we'll look at to of the latest additions to the product line, the Aseptiquik DC and Aseptiquik STC. Both products leverage the versatility of the Aseptiquik product line to bring robust solution to very specific biopharmaceutical applications we'll examine further in this post.
The first product we want to highlight is the Aseptiquik DC connector. This connector is the first all-in-one single technology to offer both a sterile connection AND disconnection. This allows for quick, easy sterile connections and disconnections outside of a sterile environment or laminar flow hood. No sealers, no welders after transfer is complete, just an intuitive click-pull twist. The disconnect is even valved, eliminating the need for a pinch clamp.
Where is this applicable, you may ask? Let's look at a recent application we helped a customer with. A contract manufacturer recently approached us to prototype a disposable manifold for them. This client had an application where they were recirculating buffer media over the course of a campaign and over the course of the campaign needed to dose into a disposable bioreactor already equipped with Colder Aseptiquik connectors. Because the campaign ran over a period of weeks, multiple ports were required off the manifold. After buffer was transferred into the bioreactor, a sterile disconnect was preferred. So with the help up Holland, the customer was able to implement a five port single use manifold equipped with seven Aseptiquik DC connectors, allowing for a sterile connection to the plastic media bag and (5) separate sterile connections to the bioreactor.
The second product we wanted to highlight is the Aseptiquik STC. Available with both gendered and gender less sterile connectors, the Aseptiquik STC incorporates Colder's Steam Thru II connector. This combination gives biopharmaceutical manufacturers the flexibility to marry single use and stainless technologies.
Why would this be useful? Imagine you have a stainless steel buffer and bulk product or media received in disposable bag. You need to find a way to steam the vessel and maintain the sterile barrier when you connect the media bag. As we've highlighted in a previous post, during an SIP cycle, a Steam Thru II connector is in the "steam on" position, allowing steam to flow through the process equipment, through the Steam Thru connector to a trap, creating a sterile connection between the connector and the stainless vessel. The Aseptiquik connector is then connected to a single use piece of equipment with a matching sterile connector. After this connection is made, the thumb latch on the Steam Thru II connector is pushed and the valve is locked into the fluid flow position, allowing for sterile transfer in or our of the stainless vessel, to or from a single use bag. Because we use a Steam Thru II connector, once transfer is complete, the Steam Thru II can be re-engaged and allow for a "steam off".
In sum, as biopharmaceutical manufacturing becomes increasingly complex, manufacturer next generation therapies, it is critical that our technologies continue to evolve. The Aseptiquik STC and Aseptiquik DC are two new products we at Holland have recently applied to help customers to address difficult process challenges. If you have a specific question about your biopharmaceutical processing application, contact a Holland Sales Engineer today.
Sanitary Jacketed Process Piping Assemblies- Things to Keep in Mind
Here at Holland, we manufacture all kinds of sanitary components. We make everything from sanitary flow orifices to pump bases, manifolds to filter holders. It's not often that any two items are exactly the same. We are the very definition of a job shop. One of the most common classes of sanitary fabrication we see are sanitary jacketed fittings, tubing, and valves. It's a regular occurrence that we get a call from someone asking us to jacket some of their more difficult items- say a Waukesha seat valve. But when we ask about the other components- the sanitary spool pieces, elbows, etc.- the client is often quick to reply, "Oh, we have someone on site for that". More times than not, this call is followed up by another call asking us to help them out with some of the pieces they thought would be a breeze. This re occurrence highlights the purpose of this post- to provide a brief overview of the challenges and common oversights people make when jacketing sanitary tubing, fittings, and various other components. As they say, the devil is in the details.
To begin, let's talk about pressure testing. At Holland, we pressure test every single sanitary jacketed component we manufacture. Why is this important? Well, there are at least six welds on every jacketed component. This leaves plenty of places for a pinhole leak. After an integrator hangs each piece, the jumper hoses are installed and the lines are pressure/leak tested. If the system doesn't hold pressure, going back and checking each spool piece, elbow, tee, and valve can be a huge time sink. The moral of the story is- pressure test each piece before you hang it. We do.
Normally, sanitary jacketed assemblies are ganged together, using jumpers to connect the heating/cooling media from piece to piece. We have seen several cases where customers had media flow rate problems from field fabricated jacketed assemblies. This was caused by the NPT jumper connectors being pushed too far in the jacket annulus, almost to the inner tube wall, effectively choking off the media flow. Make sure your fabricator properly copes the connector properly prior to welding, preventing unnecessary media pressure drop from assembly to assembly.
Another common over site when jacketing sanitary tubing is what steps are taken to ensure the inner product contact tube is centered in the outer utility tube. Especially for long, straight spool runs, it's important that the product tube is centered within the jacket to ensure efficient, uniform heat transfer. To help achieve this, we always tack spacers to the product tube prior to welding on the outer jacket, ensuring the tube will remain centered at all times.
Most sanitary jacketed assemblies used Tri-Clamp connections. Jacketing as much of the process tubing as possible is obviously important. But that can create problems as well. At some point, you will need to get a clamp around each connection, so don't weld the jacket too close to the ferrule so that the clamp will not go on. Also we have seen several instances where the ferrules faces warped as they either too close to the weld or the welder put too much heat into the weld.
It's also not uncommon to see people underestimate how much thin wall steel moves when the tremendous amount of heat required for fusion is applied. How does this present itself as a problem? Well, one component we often see people struggle with is with sanitary seat valves. When the valves are received, the valve stem is seated in the valve body and everything is clamped together and fits fine. When you go to put the jacket on, you have to remove the valve stem. When the jacket (often a crescent moon shaped jacket) is welded to the valve body, the seat where the stem sits can become distorted. To combat this, it is important to minimize the heat applied and also ensure you can correct any out of roundness that does occur. This will save major headaches down the road.
Those a just a few of the common over sites we see all the time when people decide there want to jacket their own sanitary tubing or fittings. Hopefully this post will help you with your next job. Or better yet, save yourself the headache and contact a Holland Sales Engineer today.
C Series Sanitary Pump Seals- An Overview
The C series pump is possibly the longest running sanitary pump that has ever come to market. While new centrifugal pump technologies have emerged, the C series has endured. While newer designs offer efficiency gains, magnetic drives, or are better suited for ultra-high purity or CIP applications, the C series pump's simplicity, ease of maintenance and ability to handle most clean, low viscosity fluids. While the simplicity of the C series pump has kept it around for over 50 years, largely unchanged, there have been new introductions that have allowed the pump to continue to appeal to a variety of markets. This post will focus on some of the seal variations and other modifications we've seen and attempt to highlight the differences.
Type D Seal- the type deal seal is the original and most common seal supplied with the C series pump. It is what we call an "external balanced seal". What that means is we have a rotary seal (for the series that material is carbon), rotating against a stationary seat. In this case, the stationary seat is the stainless steel backplate of the C Series sanitary pump. While this seal configuration will struggle with slurries or exceptionally hot fluids, it is ideal for beverage, dairy, and even tomato juice applications. Service kits are inexpensive and easy to replace.
Type DG Seal/Seat- While the D seal is great, customers also needed a solution for applications where they may be handling abrasive, non-lubricating products. For these applications, we recommend the Type DG seal configuration. This seal assembly uses a modified back plate to enable us to affix a silicon carbide, ceramic, or tungsten carbide stationary back plate. The type D seal is then assembled so the carbon seal from the regular D seal rides on the stationary seal we've just installed. While the carbon vs. stainless configuration of the type D seal is great for most clean fluids, the carbon vs. silicon carbide arrangement provides maximum corrosion resistance for hard to handle products. The stationary seat is reversible and existing Type D pumps can be retrofitted to take a DG seal.
Type E Water Cooled Double Seal- the type E seal is the C series version of a double mechanical seal with flush. While we don't see it often, it is out there and worth mentioning. The seal is locating within a stuffing box affixed to the pump back plate. The stuffing box is pressurized with a flush fluid, usually water and then taken to drain. This seal configuration should be considered for slurries or sticky and abrasive products where a double mechanical seal would typically be used. This is also the ideal choice for vacuum applications.
Internal Seal- One of the newest seal configurations used introduced for the C series sanitary pump is an internal seal design. Using a recessed back plate, this is the only C series pump seal that is an internal seal, meaning that the seal is located in the product zone. The internal seal (also sometimes known as a John Crane Type 21 industrial seal), has two silicon carbide seals. The stationary seat is pressed into the back plate. The pump impeller then pushes on a spring that is engaged with the rotating seal face to allow seal face contact between the two parts. This seal is great for hot fluid applications where a flush is not practical. It's also works well in applications where the pump is going to be cleaned in place. That being said, the backplate does create a large sump that cannot fully drain (a no-no for a sanitary application) and what happens if/when the seal fails? Usually, it means seal components entering the product stream- or worse. That being said, we recommend this seal for many different applications and have found it to be an especially useful in brewery applications transferring for transferring hot wort out of the brew kettle.
So there you have a quick pass at the standard seal configurations available for the C series pump. If you have any questions about your C series pump or sanitary pump application, contact a Holland Sales Engineer today.
Case Study: QF4400- NPSHr of a Self-Priming Pump
For our first post of 2017, we will be talking about a few issues and from one of most successful products in 2016- the Quattroflow quaternary diaphragm pump. Today's post will talk about NPSHA, self-priming pumps, and a specific application troubleshooting a QF4400.
Let's start by taking a look at a problem a client of ours had recently during startup of a QF4400. If you've been reading our blog, you'll know that one of the hallmark characteristics of the Quattroflow line of pumps is their ability to actually pump air and create considerable suction lift. The Quattroflow QF4400, for instance, can generate up to 4.5 meters of suction lift! Just because the pump can generate suction lift, however, doesn't mean you can't still see (or hear) cavitation at the inlet of the pump. It is important to remember the NPSH stands for net POSITIVE suction head. You can't have a "negative" suction head.Thus, every pump will have SOME net positive suction head required. If at any time the pressure at the inlet of the pump drops below the vapor pressure of the fluid being pumped, you will see and hear the pump cavitate, resulting in noisy operation and erratic flow.
This is precisely what happened during a recent FAT. A client was commissioning a skid that used a Quattroflow QF4400 as a supply pump. During the FAT, the skid was connected via hoses to some water tanks about 10' away from the skid. The water flowed from the tanks, up about 5 feet and then down through an elbow and into the QF4400 bottom inlet. While hardly ideal suction conditions, the Quattroflow was able to evacuate air from the line and draw product to the inlet. Once sufficient speed was reached, however, a noticeable chatter could be heard at the pump.
What was happening? Simple- cavitation. To understand why this was occurring, let us consider how the all Quattroflow pumps move fluid. A Quattroflow pump uses an eccentric disc to nutate the four pump diaphragms. When the diaphragms retract, a vacuum is created within the pump chamber. This actuates each of the four inlet check valves. As the eccentric disc turns, the chamber that was created is now collapsed as the diaphragm is pushed toward the valve plate. This pressurizes the pump chamber and forces fluid through the discharge valve.
As the fluid enters the Quattroflow pump chamber (pulled in by vacuum) and crosses the inlet check valve, the velocity of the fluid increases considerably. This results in considerable pressure drop. Coupled with the vacuum created at the inlet by the diaphragms, the pressure at the chamber inlet can fall below the vapor pressure of water or other aqueous products. When this happens, cavitation will occur. The result is a very noticeable clicking sound that almost sounds like a screw is loose. Rest assured, it is not.
The fix for this is simple- increase the suction head. In this instance, we used a simple centrifugal booster pump to increase the pressure at the pump inlet. We only need to go to approximately 10-15 PSI before the "clicking" sound was no longer audible.
So the next time you have a self priming pump application, remember- net positive suction head can't be negative. And if the pressure at the inlet drops below the vapor pressure of the fluid, you will hear the pump cavitate. Often times, the fix is easy- follow good piping practices or run the pump slower. If possible, increase the pump inlet pressure as well. If none of these work and you're convinced you've got a defective pump and you're feeling SOL, contact a Holland Sales Engineer today. We'd be happy to help you out.


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They buried Randy Lee Hester in Red Bay, Ala., on Wednesday.
Funeral director Dean Deaton said it was a ``serene and dignified`` funeral, attended by a few close friends, family, and the 19-year woman with red hair who was with Hester when he died in a Palm Beach County shootout.
Hester`s violent death did not surprise authorities in Alabama.
``He told a number of people he wouldn`t be taken alive,`` said Franklin County Sheriff Larry Platt. ``He didn`t want to return to prison.``
Six months ago, when he walked out of a federal prison, there were signs Hester was ready to go straight.
After serving six years of a 20-year sentence for bank robbery, he returned home to Red Bay and, at 28, was busy picking up the pieces of his life.
``He had started a business and was doing real well,`` recalled Frank Riddle, chief of police of the northwest Alabama town. ``He didn`t want to get in any trouble. Around me, he was a pretty nice guy.``
But, in January, Hester and two friends held up the AmSouth Bank in Florence, Ala., police said.
Hester eluded the FBI for more than three months, but, on April 12, a Palm Beach County sheriff`s deputy pulled a young woman over for careless driving in Palm Springs.
Deputy Vito Piazza was unaware the man sitting in the passenger`s seat was Randy Lee Hester. The red-headed woman, Rene Campbell of Austin, Texas, didn`t have a driver`s license.
Hester and Campbell ran for it and, in the ensuing gun battle, Deputy Tom Rutherford was shot in the thigh. Trapped in an alley, Campbell surrendered. Rather than give up, Hester killed himself with a bullet to the head.


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Alpelisib (BYL719)
Catalog No.S2814
Molecular Weight(MW): 441.47
Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.
Cited by 7 Publications
3 Customer Reviews
AN3CA (B), JHUEM2 (D), and MFE296 (H) cells were treated with the indicated doses of BGJ398 and BYL719 alone or in combination for 96 hours, and an SRB assay was subsequently performed.
Mol Cancer Ther, 2017, 16(4):637-648. Alpelisib (BYL719) purchased from Selleck.
BYL719 induces Apoptosis in MM cells. The effect of increasing concentrations of BYL719 (0-2.5 umol/l) for 48 h on the apoptosis of MM1s cells. The effect of BYL719 on the apoptosis signalling; cleaved PARP, caspase 3, caspase 9 by Western blotting. MM, multple myeloma.
Br J Haematol 2014 165(1), 89-101. Alpelisib (BYL719) purchased from Selleck.
A549 cell was trypsinized and plated at 50% confluence in DMEM. 16 hours later, BYL719 was added at final concentrations of 0, 1, 5, 10 and 20uM. Another 24 hours later, cells were harvested in RIPA with protease and phosphatase inhibitor cocktail. Total protein concentration was measured by BCA method. Lysates equivalent to 20ug total protein were subject to Western Blot, using total- AKT, pS473-AKT, pT286-CyclinD1 and beta-actin (internal control) antibodies.
Alpelisib (BYL719) purchased from Selleck.
Purity & Quality Control
Choose Selective PI3K Inhibitors
Biological Activity
|Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.
|In vitro
BYL719 inhibits the proliferation of breast cancer cell lines harboring PIK3CA mutations, correlating with inhibition of various downstream signaling components of the PI3K/Akt pathway. [1]
|Cell Data
|In vivo
|BYL719(>270 mg/d) shows statistically significant dose-dependent anti-tumor efficacy in PIK3CA mutant xenograft models in rodents. BYL719 has a low clearance, a half-life of 8.5 h and its exposure increases dose proportionally between 30mg/d and 450mg/d, displaying a low inter-individual variability in Cmax and AUC in human. BYL719(270mg/d) shows first signs of clinical efficacy include 1 confirmed partial response in a patient with ER+ breast cancer, and significant PET responses (PMR) and/or tumor shrinkage are achieved in 8 out of 17 evaluated patients. [1]
Solubility (25°C)
|In vitro
|88 mg/mL (199.33 mM)
|2 mg/mL (4.53 mM)
|In vivo
|Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
|30 mg/mL
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
|Molecular Weight
|CAS No.
|in solvent
Bio Calculators
Molarity Calculator
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
|NCT Number
|Start Date
|Breast Cancer
|Novartis Pharmaceuticals|Novartis
|October 22, 2013
|Phase 1
|Hepatic Impairment
|Novartis Pharmaceuticals|Novartis
|December 21, 2015
|Phase 1
|Not yet recruiting
|Recurrent or Metastatic Squamous Cell Carcinoma of Head and Neck
|Yonsei University
|October 2016
|Phase 2
|Not yet recruiting
|Carcinoma, Squamous|Squamous Cell Carcinoma|Oropharyngeal Neoplasms|Oropharyngeal Cancer
|Julie E. Bauman, MD, MPH|Novartis|University of Pittsburgh
|August 2016
|Phase 1|Phase 2
|Rectal Cancer
|howard safran|Brown University|Lifespan|Novartis Pharmaceuticals Corporation (Financial supporter)
|June 2016
|Phase 1
|Advanced or Metastatic ER+ Breast Cancer
|Novartis Pharmaceuticals|Novartis
|June 2016
|Phase 1
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.


text:
Date: 11/05/11
Views: 1202
This is the main page of your Gallery
Cameron's 1st Birthday
2011: Cameron Arrives!
Cameron's first year.
December 2010
Preparing for Cameron and the Holidays
New Years 2010 in Times Square
Holiday Lights 2009
New York City 2008
Visiting Andy and Jean Choi in New York City with Derek and Carolyn Moatz. October 24-26, 2008.
Holiday Lights 2007
Do you think we're going a little overboard? Nah...
Cycling Along the Danube
Mike and Heather take a two week break and cycled from Passau, Germany to Vienna, Austria. August 8, 2007 - August 22, 2007.
Cermak Professional Building
Together with Mike's parents, we bought the former home of the Waynesboro Ambulance Squad in August of 2006. Watch as it transforms into a professional building!
American Idol Live
Photos from the American Idol Live concert in Hershey, PA on July 12, 2006 that we went to for our anniversary.
Join us in the search for Geocaches! We are known as HeatherAndMike at Geocaching.com....
New York City 2006
Holidays 2005
Starting with our outside lights on December 1, 2005.
Our House
Our house, purchased June 1, 2004 and we're working on fixing things up.


text:
Looking for a vehicle technician you can trust? Look no further! We're the most friendly, honest auto repair team in the area.
We offer many preventative maintenance options. It's the convenient way to keep your car healthy and in top condition.
We're a Certified Bosch Services Repair Facility. We are trained, experienced professionals. Trust us as your experts in diagnostics and repairs to your vehicle.
Monday - Friday 8 am - 5 pm
Night Drop Available
Lodi, CA 95240


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The moment your lenses keep pace with changing light – and your life.
ZEISS self-tinting lenses.
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ZEISS PhotoFusion is ideal for everyone who wears glasses and especially for eyes which are sensitive to changing light. On the following pages you can learn all about the many benefits of ZEISS self-tinting lenses. PhotoFusion represents a further milestone in the history of the visionary firm of ZEISS, a history going all the way back to 1846.
*Average performance for 1.67, 1.6 and polycarbonate lenses. Performance will vary according to material, temperature and light conditions.
** Source: External consumer study, Germany, November 2012. *** Source: External study with opticians, US, January 2013.


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