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Where are the new drugs?
The push to improve the pipeline
Editor's Note: This story, originally published in 2005, has been updated.
That's less than half of the number approved in 1996, even though annual research-and-development spending by the pharmaceutical industry more than doubled—to nearly $40 billion—during the same eight-year period.
With the sequencing of the human genome has come a plethora of new technologies to mine it. Yet this new wealth of biological understanding, coupled with the growing demand for drugs that can treat and prevent chronic disease, has raised the bar for proving safety and efficacy to unprecedented heights. Consequently the search for new drugs has become more complicated—and much more expensive.
Depending on the calculations, the journey of a single pill through the convoluted development pipeline can take 15 years and cost more than $1 billion. That's before any money is spent on marketing.
Much has been written lately about the perceived excesses of drug marketing and inadequate efforts to ensure drug safety. This issue of Lens magazine begins with a look at the top of the pipeline, and how academic medical centers are partnering with industry and the federal government to replenish the shelves of society's medicine cabinet.
"Drug companies realize the need to cover a broader range of biology. They just can't do it all and never have," says Lawrence J. Marnett, Ph.D., director of the Vanderbilt Institute of Chemical Biology. "And so partnerships with universities, with academic health centers make a lot of sense."
The institute exemplifies the growth of translational research programs at universities around the country. Aided and encouraged by the federal government, these efforts are designed to develop the tools and the knowledge base needed to meet today's drug-development challenges.
"Our goal is to take those very early stage discoveries around drug targets and lead compounds, and go another step toward handing that information off to biotechnology and pharmaceutical companies and other organizations that can hopefully translate our discoveries into new drugs for patients," says Jeffrey Balser, M.D., Ph.D., dean of the Vanderbilt University School of Medicine and associate vice chancellor for Research.
Toward that end, the VICB in 2005 opened a high-throughput screening facility to help search for small molecules (a class of organic chemicals) with drug-like activity. Vanderbilt also has signed a master research agreement with biotechnology giant Amgen to conduct an array of collaborative research projects.
The intent of these efforts is to encourage Vanderbilt researchers to pursue the therapeutic potential of their discoveries.
Discovering a potential drug target is not enough, explains Jeffrey Conn, Ph.D., director of the Vanderbilt Program in Drug Discovery. If academic scientists took the next steps—identifying a compound that acted on the target, and conducting the laboratory and animal tests necessary to validate its therapeutic potential—you can then justify a company really locking into a full-scale drug discovery program, he contends.
Jennifer Washburn, author of University, Inc., is more than skeptical. In the February 2005 issue of The American Prospect magazine, she wrote: "Instead of honoring their traditional commitment to teaching, disinterested research, and the broad dissemination of knowledge, universities are aggressively striving to become research arms of private industry."
Gordon R. Bernard, M.D., assistant vice chancellor for Research at Vanderbilt, disputes that contention.
While collaborations with industry can result in conflicts of interest, many universities, including Vanderbilt, have implemented procedural and contractual safeguards to identify and manage such conflicts. These safeguards protect the academic mission while permitting opportunities to transfer new information and technologies for the benefit of society, he says.
Marnett agrees. "We are not going to be drug companies. But we can advance the field," he says. We can identify new therapeutic concepts, new drug-design concepts. That's what we should be doing."
Turn up the light
Where will the new drugs come from?
One area to watch: G protein-coupled receptors (GPCRs).
GPCRs are embedded in the membranes of nearly every cell and are the most common conduit for signaling pathways found in nature.
Two-thirds of all drugs target these receptors. The beta-blocker drug propranolol lowers blood pressure by preventing adrenaline from binding to its GPCR. Drugs that are given to relieve symptoms of Parkinson's disease act through a GPCR that binds dopamine.
Parkinson's disease illustrates the complexity of the signaling pathways that utilize GPCRs. Characterized by tremors, difficulty walking and muscle weakness, the disease is caused by the progressive loss of dopamine-producing nerve cells and the resulting lack of dopamine, a neurotransmitter involved in the coordination of muscle movement.
Current dopamine replacement therapy squelches the tremors and improves coordination, but prolonged use of the drugs can cause significant side effects, including involuntary muscle movements and hallucinations, and the medications become less effective as the disease progresses.
Because loss of dopamine disrupts a complex web of signaling pathways in the brain, it may be possible to restore this balance by "tweaking" pathways involving other neurotransmitters.
While at Merck Research Laboratories, where he was head of neuroscience, Conn and his colleagues found that activating a particular GPCR that bines the neurotransmitter glutamate—mGluR4—relieved symptoms of Parkinson's disease in animals. However, they could not find a compound that binds only to mGluR4, and does not activate other glutamate receptors elsewhere in the brain.
Allosteric modulation might solve the problem.
This tongue twister refers to the ability of some compounds to bind to a secondary site on a receptor in a way that "modulates" its activation by a primary "ligand" such as a neurotransmitter or hormone. Primary ligands fit into the receptor's main binding site like a key fitting a lock, and "turn it on."
The modulator, on the other hand, acts like the dimmer switch in an electrical circuit, adjusting the intensity of the receptor's activation. The anti-anxiety drugs Valium, Xanax, Librium and Ativan, for example, "potentiate" or turn up the activity of the benzodiazepine receptor when it binds to its primary ligand, the neurotransmitter gamma-aminobutyric acid (GABA).
Conn wondered whether he could find an allosteric potentiator that was specific for mGluR4. However, "my department could only handle a maximum of three programs at any given time," he says. "And to take a kind of half-baked idea… and decide we're going to really pull the trigger on a drug discovery program was such a high risk."
Then, in 2003, he saw an opportunity to pursue his idea at Vanderbilt.
A generation ago, Conn might have spent his entire career searching for a compound that could modulate mGluR4 activity. Now, thanks to Vanderbilt's high-throughput screening facility, he and his colleagues can test tens of thousands of small molecules for drug-like activity in a single day.
Ultra low volume liquid handlers squirt nanoliter amounts of the compounds into 384-well "microplates" containing their target. Reactions are detected via fluorescence or luminescence as the plates are maneuvered by articulated robots through the screening system.
Compounds that bind to the allosteric site on mGluR4 will be tested in animal models of Parkinson's disease to see if they actually relieve muscle rigidity and restore coordination.
Conn admits that there is considerable skepticism among his colleagues in industry about "whether we can really pull it off." But that hasn't discouraged universities across the country from developing similar capabilities for screening compounds.
"I see it as a really challenging time. But mostly I see it as a very exciting time."
Pie in the sky
Another potential source of new drugs: compounds that interact with G-proteins.
G-proteins are intracellular molecular switches, involved in nearly every physiological—and presumably, pathological—process. They translate and transmit signals from the receptor to the "response machinery" deep inside the cell.
Here's how they work:
Drugs that target GPCRs are rather blunt instruments; they can trigger far-ranging side effects. Is it possible to develop drugs that can be delivered—with "nano-surgical" precision—to the G protein of a specific receptor inside a particular type of cell? Could that achieve the therapeutic manipulation of a unique signaling pathway without affecting physiology anywhere else?
That prospect has tantalized Heidi Hamm, Ph.D., for more than two decades. But until recently the idea was, as Hamm puts it, "total pie in the sky."
In 1993, Hamm helped solve the structure of the alpha subunit with the late Paul Sigler, M.D., Ph.D., and his colleagues at Yale.
More recently, she and colleagues at the University of Illinois at Chicago and the University of Wisconsin-Madison showed how the beta/gamma subunit of an inhibitory G protein controls the release of neurotransmitters and hormones. It prevents vesicles containing these chemical messengers from fusing to the cell membrane and spilling their contents outside the cell.
The discovery, reported in 2005 in the journal Nature Neuroscience, could lead to new ways to treat conditions as diverse as pain and diabetes.
Hamm admits that G protein "therapy" is unlikely to attract major drug company investment—at least not yet. So several years ago, about the time she was moving from Northwestern University to Vanderbilt, she and her colleagues formed their own drug discovery company in Evanston, called cue BIOtech.
They chose to study a receptor embedded in the membrane of clot-forming platelets that binds the coagulation factor thrombin.
Blood clotting is essential for wound healing, but too much thrombin in the wrong place can trigger a heart attack. Blood-thinning drugs like Coumadin can prevent platelets from forming clots, but—unless the dose is carefully monitored—they can cause uncontrollable bleeding.
It has been difficult to block thrombin, which actually is an enzyme that activates its receptor by chopping it in half. So Hamm and her colleagues are trying to tackle the problem from inside the cell, by blocking receptor action instead of receptor binding.
So far they've been able to make "very potent" small molecules that prevent the thrombin receptor from binding to or activating its G protein. "In cells—we haven't gotten to animals yet—they do exactly what we want them to do," she says. "They're inhibitors of platelet aggregation."
Drug companies are still skeptical, but now at least Hamm's idea doesn't seem so pie in the sky.
The role of government
The onerously high cost of making new drugs has not escaped the attention of federal health officials.
In a 2004 report entitled "Innovation or Stagnation: Challenge and Opportunity on the Critical Path to New Medical Products," the U.S. Food and Drug Administration called for increased public-private collaboration to boost drug development through the application of new technologies.
"We must modernize the critical development path that leads from scientific discovery to the patient," the report urged.
Developing new tools to aid drug discovery also is the goal of the Molecular Libraries Screening Center Network, established in 2004 by the National Institutes of Health as part of its Roadmap initiative to help translate new scientific knowledge into "tangible benefits for people."
The aim is harness the fruits of the genomic revolution, make them available to scientists in universities and industry alike, and encourage them to work together as never before, explains Christopher Austin, M.D., senior advisor for translational research at the National Human Genome Research Institute.
"What we hope to do… is the high capital investment… take the assay, do the robotic screening on a big library, do some initial chemistry, and give (scientists) back a small molecule compound which allows them to query the function of that gene or pathway—to test a hypothesis," Austin says.
The federal efforts have their share of skeptics, including Steven Paul, M.D., president of Lilly Research Laboratories. "I am worried that obtaining the kind of molecular probes required for even in vivo testing may prove to be too time-consuming and expensive," Paul says, "and may divert precious NIH funds away from basic or clinical biomedical research."
The federal initiatives in no way are meant to diminish government's role in supporting fundamental discovery, Austin responds. Tools developed by the public sector, however, can help establish the therapeutic potential of new compounds, and encourage industry to push them through the pipeline.
"As long as… we're all aware of what we can do and can't do, I think we'll be fine," he says.
View Related Articles:
Why do drugs cost so much to develop and to buy?
Thinking outside the cell
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Volos 2/6/2017
Prof. C. C. Baniotopoulos, PhD, Prof hc School of Engineering, University of Birmingham Friday 2-06-2017 at 12:00 Room Α, Department of Civil Engineering Synopsis: The use of steels with higher strengths (400 to 960/1100 MPa) can lead to significantly lighter structures as soon as limitations on stability and deflection can be overcome. Although widely used in automotive and machinery industry, structural applications still remain scarce. Current research activity investigates innovative cross-sections, joints, structural arrangements, and design methods including pre-stressing technologies that enable the assets of high strength steels to be maximised. The work focuses on long-span roof applications, typically used in open stadiums, closed arenas, and exhibition halls as well as tall wind turbine towers.

subset: commoncrawl


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Super strong and abrasion resistant, this non-PVC mid-weight dry bag has space saving low profile Hypalon lash loops on the sides for secure stacking and a roll-resistant oval shape. A great choice for rugged water sports like kayaking, canoeing and rafting. Suitable to keep contents dry in any wet situation where the bag is not submerged.
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Yummy Diabetes-Friendly Salad Recipes
Buffalo Chicken Salad
Need a healthful meal in a flash? This low-carb salad has the spicy kick and satisfying crunch of your favorite restaurant-style Buffalo chicken without the extra calories and fat. And it only takes 15 minutes to toss together.View the Recipe
Clementine-Arugula Salad with Lime-Poppy Seed Dressing
This citrus-infused side salad will surely be a hit around the dinner table. Plus, it takes less than 20 minutes to make and boasts only 14 grams of carb per serving.View the Recipe
Maple Mahi Mahi Salad
You won't need to fish for compliments when you serve this main-dish salad that's packed with protein, healthy fats, and fiber. They'll be begging for the recipe before the meal is over.View the Recipe
Superfoods Salad
Spinach, strawberries, blueberries, and walnuts sometimes are called superfoods because they are loaded with antioxidants, which are often touted as contributing to good health.View the Recipe
Cantaloupe and Cucumber Salad
Use a vegetable peeler to make beautiful ribbons of the cantaloupe and unpeeled cucumber. You'll love this fresh take on the classic flavor combination of sweet and salty that also features feta cheese, mint, and basil.View the Recipe
Asian Pork and Cabbage Salad
A homemade orange-sesame dressing adds an enticing flavor to the stir-fried pork in this low-carb salad. It's fast, fresh, and easy to toss together for a cozy night in.View the Recipe
Bacon Salad Dressing
Mmm, bacon! Enjoy this bacon-infused, low-carb salad dressing with your favorite veggie salad combinations. We recommend spinach, toasted walnuts, and juicy cherry tomatoes.View the Recipe
Kickin' Chicken Taco Salad
This low-calorie taco salad is a perfect meal makeover for our hearty (and heart-healthy) chicken chili. Toss the reheated chili over your favorite salad fixings, and voila -- new tasty meal from yummy leftovers.Chicken Chili Recipe
Grapefruit and Kiwifruit Salad
Tart grapefruit, sweet kiwifruit, and a little spicy fennel is a combination sure to send your taste buds on a roller-coaster ride of enjoyable flavors and textures.View the Recipe
Blood Orange and Watercress Salad
Put a twist on boring side salads with this low-carb recipe that features sweet blood oranges and vitamin-rich watercress. If you can't find fresh watercress, substitute with any fresh greens.View the Recipe
Salmon and Spinach Salad with Flaxseed Dressing
The protein and healthy fats in salmon and the fiber and nutrients in flaxseed can help you feel full longer. So this main-dish salad is not only delicious, but it can also promote heart health and weight loss.View the Recipe
Easy Taco Salad
Skip the Mexican takeout with all of the chips, greasy meat, and extra calories. This easy taco salad is packed with 17 grams of protein and two servings of healthy vegetables, and it has only 235 calories.View the Recipe
Panzanella Salad with a Twist
This delicious version of Italian panzanella, a bread salad, opts for grapes instead of tomatoes and boasts only 17 grams of carb per serving.View the Recipe
Warm Spinach Salad with Roasted Red Peppers
Turkey bacon and reduced-fat feta cheese to keep the fat and calories low, this warm spinach salad is hard to pass up. Though it's pictured here with fish, it also fits nicely along side your favorite main dish.View the Recipe
Mediterranean Chicken Salad
When you're grilling or broiling chicken breasts, cook some extra pieces to use in this salad. Or if you prefer, pick up some packaged cooked chicken breast strips or cubes at the supermarket.View the Recipe
Scallop Salad with Basil Vinaigrette
Balsamic vinegar adds a touch of sweetness to the light basil dressing that partners deliciously with the scallops, greens, and mixed veggies.View the Recipe
Mexican Chicken Salad Stacks
If you're in a hurry, simply toss the ingredients together and serve this seasoned-chicken medley in salad bowls.View the Recipe
Turkey-Broccoli Salad with Grapes
Rich in vitamins C, A, and K, broccoli slaw mix makes this salad nutritious as well as super easy to prepare.View the Recipe
Caesar-Style Salad with Crispy Parmesan Rounds
This flavorful salad is simple enough for a weeknight meal yet special enough for a dinner party.View the Recipe
Asian Tofu Salad
The slices of protein-rich tofu that top this salad are seasoned in a chili sauce-and-peanut butter marinade and sauteed in sesame oil for bold, rich flavor.View the Recipe
Cranberry Cucumber Salad
With a lot of low-calorie veggies, a slimmed-down dressing, and just a sprinkling of dried cranberries and olives, this colorful tossed salad comes up a nutrition winner.View the Recipe
Layered Southwestern Salad with Tortilla Strips
Break out of that salad rut with this zesty slimmed-downed Tex-Mex medley topped off with a light sour cream dressing and homemade tortilla chips.View the Recipe
Chicken, Pear, and Parmesan Salad
The convenience of purchasing already-prepped produce comes with a cost. Save yourself time later by chopping and slicing your produce all at once when you get home from the grocery store so the ingredients are recipe ready.View the Recipe
Kale Salad
Take a break from the same old lettuce salad. Try this creative mix of kale, tomato, and sweet pepper tossed with a captivating Asian dressing.View the Recipe
Cobb Salad
In the 1920s, Bob Cobb was the manager of the Brown Derby Restaurant in Hollywood. He created the classic version of this hearty salad as a way to use leftovers. This recipe is a healthful adaptation that keeps calories, carbs, and fat in check.View the Recipe
Mediterranean Beef Salad with Lemon Vinaigrette
This low-carb, high-protein salad with refreshing lemon vinaigrette has less than 200 calories.View the Recipe
Chicken-Brown Rice Salad
When summertime comes around, it's nice to have a variety of salad recipes at hand. You can whip up this one in minutes, leaving lots of time to enjoy the great outdoors.View the Recipe
Fajita Beef Salad
Lime does double duty in this recipe, playing a key role in the marinade and the dressing. Its tart flavor enhances the grilled beef, tomatoes, and honey-kissed dressing.View the Recipe
Spinach-Pasta Salad with Shrimp
This salad blends shrimp and pasta on a bed of spinach for less than 250 calories.View the Recipe


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The playmaker has impressed since moving from the Bundesliga on a season-long loan last summer and the Toffees have agreed a three-year deal with the player.
Pienaar, a product of the South African arm of Ajax´s youth academy, has played 35 games this season scoring twice so far.
Copyright (c) PA Sport 2008, All Rights Reserved.
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PALM BAY -- A man armed with a high-powered rifle and a handgun turned two suburban shopping centers into a shooting gallery on Thursday, killing six people including two police officers and wounding as many as 15 more, police said.
The man was subdued when officers stormed a Winn Dixie grocery store with concussion grenades and tear gas after several hostages were released. Police thought the gunman was alone when they rushed in, but three Winn Dixie employees had fled into a refrigerated cooler and had to be freed by police.
The man, handcuffed after a struggle, was identified as William Cruse, about 60, a resident of this coastal suburb of Melbourne.
Police were withholding the names, ages and sex of the victims pending notification of their families.
Three gunshot victims were pronounced dead at Holmes Regional Medical Center, and three were found dead in store parking lots, police said.
Of the wounded, a 16-year-old boy, was in critical condition with a gunshot wound to the abdomen and five other people were in serious but stable condition after surgery, according to Dr. D. Scott Gettings, director of emergency medicine at Holmes Regional Medical Center.
Three others were hospitalized and four others were treated and released, he said. One of the injured was an infant hit by shrapnel.
The shooting apparently started in front of Cruse`s home Thursday evening after two boys teased the man, a neighbor, Marguerite Hall, told The Orlando Sentinel. She said Cruse fired at the boys and then got into his car and drove away.
Moments later, the gunman opened fire in front of a Publix supermarket at the Sabal Palm Shopping Center across the street from the Winn Dixie store at Palm Bay Shopping Center.


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Housing Navigator
825 E Orange Grove Blvd. Pasadena, CA 91104 | Full-Time Temporary
We are hiring for a full time, temporary Housing Navigator in Pasadena, CA.
The hours are M-F, 8am-4: 30pm.
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- Experience assisting low and very-low income individuals access affordable housing.
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This role pays $18 an hour.
If you are interested and can interview and start quickly, please send the most updated copy of your resume and a good time to contact you to firstname.lastname@example.com
Thank You,
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National Recruiting Manager
888-651-8367 x4787
Brooke Olson
National Recruiting Manager
We strongly recommend using any browser except IE9 since it is no longer supported by Microsoft. This will ensure that your resume and information are properly received.


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Greetings! I wanted some advice on some crystals to use for focus and creativity. I am writer and want a crystal that will move my energy away from procrastination and assist me on focusing and creativity as I write. Do you have any suggestions? Thank you for your time and many blessings to you.
Hi Y:
Thanks so much for your question about crystals to help with focus and procrastination. I like Lapis Lazuli & Fluorite for focus and Blue Tiger Eye and Red Jasper for motivation. I also really like Pink Aventurine for a spark of creativity and to get past any writer's block.
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Brand Label: Cire Trudon
ITEM MOVED TO ARCHIVE: On October 28, 2017 2:04 am, Fashion Stylist Online noted this item may be out of stock at Farfetch US because it was not referenced in their latest online catalog. If this item is out of stock at Farfetch US, you may be able to find similar fashions sold there or elsewhere on our Cire Trudon Designer Brand Directory.
Available for Purchase Online at Farfetch US for $145.00Pin It
Green wax Odeurs Royales candle set from Cire Trudon. This item is unisex. Size: One Size. Material: Wax/glass.
Shop other brand label items from Cire Trudon on FashionStylist.com.
This item was published for sale online by Farfetch US on October 23, 2017 10:15 am and last updated by us October 28, 2017 2:04 am.
Editor Picks: Giving Tuesday One for One Toms Shoes
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Mar 02, 2014
Globe and Mail Editorial : Mar 2nd, 2014
"Home daycares provide a vital service, offering parents a convenient, cost-effective alternative to their licensed counterparts, which are typically more expensive and where space is in short supply. It is precisely because so many families choose this option – 80 per cent of children in daycare are at unregulated facilities – that government should take a closer look at how they operate, to see if there are any risks they pose to children's welfare."
Click here to read the full article.
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I had no problems with TomTom XXL 550 I bought. It works great and this is indeed one of the best GPS units on the market. A TomTom XXL 550 shows off a 5-inch widescreen LCD display which helps me read the map clearly and thankfully, it is a relief to my now failing eyesight.
TomTom XXL 550 has an easy navigation. This unit has been designed with a 2-inch loudspeaker panel at the back, and has a really good quality audio. I love the trip roaming as it took place quickly, and turn-by-turn guidelines were succinct and apparent.
I received the unit with the manual that has laid down optional settings and a fully-loaded version that puts in lifetime map and traffic updates. The traffic feature really works well and the routes that it chooses are typically appealing good. I found myself coming across for non-existent ramps and exits. So, TomTom XXL 550 with its lifetime map updates will expectantly get rid of such displeasures
I also come to appreciate more TomTom's customer service department. Within a day I got an issue raised resolved. They're extremely helpful and considerate.
I personally believe that the Tomtom user interface is one of the best. To sum up, the TomTom XXL 550 do exactly what it's advertised to do – nothing more, nothing less. While giving me more than I expect, the unit, at the same time, offers an affordable alternative to sophisticated and more expensive GPS units. TomTom XXL 550 is definitely the best gps portable device on the market.


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Share the Wealth Sunday Link Up {#45}
Do you have a great money saving idea—or want to hear what other people are doing to save money and still feel like they are living the good life—even on a budget? It's that time of the week again: Share the Wealth Sunday Link Up time! I look forward to sharing (and learning!) many great money saving ideas again this week! Come visit us on social media and say hi! We'd love to get to know you more! It would be great if you would follow us too:
Hannah at eat, drink & save money | Facebook | Pinterest | Twitter | Google+ | Instagram
Lisa at Fun Money Mom | Facebook | Pinterest | Twitter | Google+ | Instagram
Gina (that's me!) at Money Savvy Living | Facebook | Pinterest | Twitter | Google+ | Instagram
Suggested guidelines:
- Link to anything that can save people money: recipes, DIY, crafts, printables, tutorials, or any and all personal finance/budgeting ideas
- Leave up to three links that you have not linked up within the last six months
- Leave specific links to posts (not your entire blog)
- Do not link to any Etsy shops
- Grab the Share the Wealth Button for your blog
- Have fun! Check out the other great money saving ideas…and share/interact with as many as you can!
- Follow your hosts on Facebook and other social media—we want to stay in touch!
- Link your post back to this site so others will know about the party each week!
East, Drink & Save Money: Guilt Free Indulgence: Banana Nut Waffle Breakfast
Fun Money Mom: Celebrate Viva Italia with Italian Stuffed Chicken
Money Savvy Living: 5 Easy Ways to Get Rid of Credit Card Debt
Share the Wealth Pinterest Group Board:
Check out our Share the Wealth Pinterest Group Board! Come on over and pin your most recent posts or other great pins that you want to share with the group. This is a great way to get a little boost for some of your pins, but make sure that you return the Pinterest love and pin something from a few other bloggers.
Also, don't forget to follow your Share the Wealth Sunday hosts on Pinterest too:
Share the Wealth Facebook Page:
Have you joined the Share the Wealth Facebook page yet? Come on over and mingle with other bloggers, share your content, find other great content to share and ask questions/get advice. We'd love for you to join us! This is meant to be an interactive group for bloggers… feel free to invite any of your blogger friends!
Healthy Living Facebook Page:
Did you make a New Year's Resolution to lose weight or get healthy? (or decided on a New Year's Transformation instead!) Stop by my Healthy Living Facebook page for some tips, recipes, and encouragement to get healthier and lose a little weight this year. Also, feel free to join and post your health-related blog posts anytime… another great way to share your blog posts!
Round Up:
Each week, I will pick a few awesome posts from the week before to share with you. That will mean additional exposure for your post and blog! Here some of my favorites from last week:
Do You Really Need a Shopping List to Save Money on Groceries?
Budgeting 101: Creating a Budget
4 Reasons Today's Kids Need to Understand Money
How to Naturally Dye Easter Eggs
Feel free to grab this 150 x 150 button and share on your page to let others know about this link up:
Link Up:


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Home | Contact
Us | Features & Pricing | About
Us | Login
Introducing a ground-breaking community outreach tool for today's schools.
inSchoolHub provides current and critical two-way communication between faculty
and the community that will help to improve safety and public relations.
Use Push Notifications to share important information immediately to the mobile
devices of parents and caregivers, keeping them apprised, in real time, of current
and developing situations.
Keep families informed of the various day-to-day activities on your campus through
the regular posting of Bulletins and Updates.
Use the Event Calendar to keep families aware of scheduled activities on your campus,
as well as district-wide events of interest.
With the simple touch of a button the app will display a form that allows users
to share potentially vital information with school administrators, anonymously if
that is what the sender prefers.
The Contact Us button gives the user a means to easily send questions and comments,
further expanding lines of communication and strengthening the relationship between
schools and the neighborhoods they serve.
The App also features a Call button, making it easy to reach the front office with
a single touch.


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PACO Packs A Lot Into a Little
PACO is a tiny little cube, only 3 meters square (just slightly bigger than the Micro Compact Home) but complete with everything you need. It can hook up to the established service infrastructure or stand on its own with solar, wind, water recycling and bio-toilet.
The structure is relatively simple, and the cost starts at
only 4,200,000 yen (US$ 47,122) for a basic shell, up to 6,300,000 (US$ 70,705) or US$657 PSF for a complete unit with kitchen, shower, bathroom and lighting.
it is designed by Jo Nagasaka and Schemata Architecture Office
As our source, What We Do Is Secret says, "Ain't it cute?"
The Micro-Compact Home on TreeHugger
Home Delivery: The Micro Compact Home Comes To America
Micro - Compact House
Microcompact House: Smaller than Paris Hilton's Jail Cell :


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For seventy five years, Benson & Clegg has dressed the modern gentleman from its premises in London's St James's. Tailors to His Majesty George VI, Harry Benson and Thomas Clegg created a unique tailoring profile which continues to this day: the clean, square shoulder and profiled waist which over the years has been appreciated by famous customers from Maurice Chevalier to Charlie Watts of the Rolling Stones.
Today, all of Benson & Clegg bespoke suits are handmade at brand's premises in Piccadilly Arcade just off London's Jermyn Street, complemented by label's unique range of handmade British accessories: buttons, cufflinks, ties and badges. Benson & Clegg is the contemporary face of authentic British tailoring, ensuring that its customers from all over the globe are always dressed for the occasion.
The Benson & Clegg line of accessories is very much derived from brand's bespoke tailoring heritage. Each one of its cufflinks, ties and badges are crafted with the same level of precision and expertise that goes into a tailor made garment.
Mark Gordon, the managing director says: "Benson & Clegg stands out other companies in that it is a company with a unique heritage. I believe that our company stands out because it has adhered to its core values and remained true to itself and its history. We have not compromised our dedication to the highest quality in favour of cutting corners to lower prices. We make the highest quality UK made products using skilled artisans, the finest materials, combined with a superlative customer service. The Benson & Clegg name stands as an embodiment of those values which customers can consistently rely on".


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Liquor Control Commission is located at 927 Country Club Rd # 200, Eugene, OR. This location is in the Cal Young neighborhood. This business specializes in Government.


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Citizens approves pay increases after raising rates
Last year Citizens Insurance premiums increased 10.8 percent. The company said, despite billions in the bank, they needed more money because if we were hit by a major storm, they wouldn't have enough money to pay claims.
But now we're learning they do have enough money to pay millions of dollars in raises for their top executives.
"We didn't need the insurance coverage last year, thank God we didn't have any claims, but that doesn't give them the right to go and spend that money however they choose to," said Cindy Gomez who is covered by Citizens property insurance.
Gomez pays thousands of dollars a year to insure her home in East Naples. While she's working to keep up with premiums that have nearly doubled for Citizens property insurance, the executives at the government-backed company are spending millions for luxury trips, hotel stays and lavish dinners—and now they're also getting pay raises.
"Shame on you. Why do you get to spend what you want, when you want, how you want and have no accountability," Gomez said.
In January an inspector general report found executives using the corporate credit card to finance $900 dinners, drinks included.
"Why does a government employee get to drink on my dime?" Gomez said.
The company CFO went on a $35,000 tour through four different countries—staying in four star hotels—one in Bermuda costing more than $600 a night.
"The consumer is the one that's getting it right between the eyes and getting these ridiculous premium increases and for what purpose so we can send them all to the golf course and out on trips and philandering around?" Gomez said.
This year that same CFO, Sharon Binnun, is getting a $31,000 pay hike—bumping her salary by 14 percent.
Another top executive, Christine Ashburn got a 24 percent salary increase—she's now making $130,000 a year.
"How do you sleep at night and look in the mirror? It's sinful," said Jim Space, who has since switched to private insurance.
A Citizens' spokesperson told NBC2 the company's expenses are not responsible for pushing up rates.
The company's CEO, Barry Gilway, who makes $350,000 a year—said the pay hikes were necessary to remain competitive with the private market.
NBC2 called the governor's office to see if they are going to force the company to change their spending habits, but haven't heard back.
Click here to see the pay increases for Citizens Insurance executives from 2012 to 2013.


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Sir Paul McCartney's ex-wife Heather Mills has denied she hit a member of the International Paralympic Committee (IPC) during a heated bust-up in Austria.
The former model, who had hoped to compete with the British ski team at the Paralympic Winter Games in Russia next year (14), was accused of throwing a "tantrum" and yelling at IPC executive Sylvana Mestre after she was told her equipment breached regulations.
Other witnesses allege she grabbed Mestre during the confrontation at an Austrian hotel on Monday (16Dec13), but Mills is adamant the bust-up never became physical, saying, "I never physically touched her... she's never made a statement saying I physically harmed her... These reports saying that I hit her are just tabloid rubbish."
Mills pulled out of qualifying heats for the games in Sochi after officials told her she would not be able to compete using her preferred equipment as it breaches competition regulations.
IPC bosses have confirmed they are considering taking disciplinary action against Mills following her outburst on Monday.


text: I ordered a Wii-Boss from DealExtreme.com a little while ago and it came today. I've already taken my Wii apart and I was wondering if anyone had some suggestions for installation. I figured I'd use .22 solder and pre-solder the contacts. BTW, the "fake/stolen" chips from DX are perfect. Great condition and as soon as I'm done with installation, I'll let you know how well it works.


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Basic approaches to discrete simulation have been process simulation languages (e.g., GPSS) and event-scheduling type (e.g., SIMSCRIPT). The trade-offs are that event-scheduling languages offer more modeling flexibility and process-oriented languages are more intuitive to the user. With these considerations in mind, authors David Elizandro and Hamdy Taha embarked on the development of a new discrete simulation environment that is easy to use, yet flexible enough to model complex production systems. They introduced this environment, Design Environment for Event Driven Simulation (DEEDS), in Simulation of Industrial Systems: Discrete Event Simulation in Using Excel/VBA. The DEEDS environment is itself an Excel/VBA add-in. Based on this foundation, the second edition, now titled Performance Evaluation of Industrial Systems: Discrete Event Simulation in Using Excel/VBA incorporates the use of discrete simulation to statistically analyze a system and render the most efficient time sequences, designs, upgrades, and operations. This updated edition includes new visualization graphics for DEEDS software, improvements in the optimization of the simulation algorithms, a new chapter on queuing models, and an Excel 2007 version of the DEEDS software. Organized into three parts, the book presents concepts of discrete simulation, covers DEEDS, and discusses a variety of applications using DEEDS. The flexibility of DEEDS makes it a great tool for students or novices to learn concepts of discrete simulation and this book can form the basis of an introductory undergraduate course on simulation. The expanded depth of coverage in the second edition gives it a richness other introductory texts do not have and provides practitioners a reference for their simulation projects. It may also be used as a research tool by faculty and graduate students who are interested in qoptimizingq production systems.When these functions are well managed, an appropriate level of customer service can be maintained without excessive inventory levels. ... This example is adapted from [1], where it is modeled using the discrete event language SLAM II.
|Performance Evaluation of Industrial Systems
|David Elizandro, Hamdy Taha
|CRC Press - 2012-04-11
You must register with us as either a Registered User before you can Download this Book. You'll be greeted by a simple sign-up page.
Once you have finished the sign-up process, you will be redirected to your download Book page.How it works:


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By Tim Hynes, Fraternity St Maximilien Kolbe Member
"I can't believe it, but the year 2014 will mark two years since I joined the Fraternity of Maximilian Kolbe within Heart's Home. So much in my life has changed since then. At the time I was a software engineer with a frenetic schedule, traveling constantly; now I am seminarian studying for the archdiocese of Boston with a markedly less hectic, though no less full calendar. With so much on my plate, I have never been completely sure how to live out my commitment on a day to day basis. Living on one's own is quite a different experience than living in a Heart's Home Center and it can be easy, often too much so, to forget what one has lived in Brooklyn, Lima, Tegucigalpa, and in so many other places in the world…
For me, this is precisely what the yearly Frat Max retreat provides: A place to remember, reflect, and renew. Sharing with new members and old (by God's grace it seems that the Frat grows a little each year), I am reminded of the manifold ways in which the charism of Heart's Home and the Frat can be lived out in each of our lives, no matter how different they might be. I am reminded that while I may live far away from Brooklyn or Woodbourne, NY, I am nonetheless connected to my brothers and sisters of the fraternity in the unity of the body of Christ, as I seek to serve Him in compassion and friendship with those whom He has placed in my life.
This year in particular it was important for me to renew my relationship to the Frat and my commitment as I adjust and transition into the new life I feel called to lead. Yet, at the same time, I know I am not alone; life is not static and the past year saw big changes not only for me, but for many others in the Frat with engagements, marriages, new children… We are all adapting and growing with each new experience that life brings along. So too our relationship and understanding of the Frat which, when we take the time to reflect and renew, grows dynamically along with us."


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After the first causalities of Hurricane Isaac in Louisiana were found dead and floating in a kitchen filled with Isaac's floodwaters in eastern Plaquemines Parish late Thursday, deputies and others feared they would discover more bodies Friday as the inundation receded and crews could more effectively search flooded out homes. As of late in the day, no additional bodies were found.
John Marie, the parish coroner's investigator, said the two people have been tentatively identified, but their names are being withheld pending notification of relatives.
Sheriff Lonnie Greco's deputies spotted the deceased man and woman in their mid 40s a home on Scarsdale Road in Braithewaite, which was submerged by water on Wednesday that overtopped back levees from the parish line down to White Ditch. The deputies hooked the bodies and dragged them through the window, said Plaquemines Parish President Billy Nungesser. Officials had learned of the deceased from other people they had rescued from flooding and brought to a Belle Chasse shelter.
No other deaths from Isaac had been reported at 7 p.m. Friday evening. "Hopefully," Marie remarked, "we don't have any more."
On Friday, outside his parish's Emergency Operations Center, Nungesser said that water levels had gone down on both sides of the parish. He said it had subsided 5 to 6 feet on the west bank of the Mississippi River, but he did not know how much it had dropped on the east bank. But several people who had travelled Braithwaite by boat earlier that day said that the water at that time still covered the tops of trucks.
Crews throughout the day were deployed to check the interiors of residences for fatalities or - less likely at this point - people who survived the flood but were still trapped in a home underwater, according to Nungesser.
"It is very unlikely that someone is in a (submerged) house that survived," Nungesser said.
Nonetheless, officials are implementing measures to speed the reduction of water levels. Aside from the state's intentional breach of a back levee that had been trapping upwards of a dozen feet of Isaac's flood waters in eastern Plaquemines on Thursday, local and federal engineers are assessing the possibility of creating other breaches in the coming days, said Guy Lagaist, the parish's director of emergency operations.
Lagaist also said that the parish had activated as many drainage pumps as were functional to help remove the water.
Meanwhile, Nungesser said that numerous southern Plaquemines residents remain cut off from the northern area due to flooding on both Louisiana 39 in the east and Louisiana 23 in the west. But he said that while such residents are without power, they are not in need of immediate rescue.
Members of the National Guard airlifted ice, MREs and water to first responders and the stranded in those communities on Thursday, Lagaist said.
As soon as the roadways to southern Plaquemines are passable, Nungesser said he will permit those who were either evacuated or rescued to return to their homes.
On Thursday FEMA announced that Plaquemines is among several parishes whose residents may have access to financial assistance for Isaac-related damage. In a statement Friday, Sen. Mary Landrieu, D-La., said FEMA Administrator Craig Fugate was directing "the agency's response (to the storm) from on the ground," and she vowed to keep "pushing for improved flood protection for areas of our state that so desperately need it." The problems in Plaquemines during Isaac occurred in areas that are outside the federal levee system.
On a more personal note, in an email asking news reporters to not call him on his private cell phone, Plaquemines government spokeswoman Caitlin Campbell wrote that Nungesser has been dealing with Isaac while his mother has been gravely ill.
"As you can imagine, he is going through an extremely difficult time because of ... Isaac."
Staff writer Benjamin Alexander-Bloch contributed to this report. Ramon Antonio Vargas can be reached at email@example.com.


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Preheat the oven to 350 degrees F. Shave the Brussels sprouts crosswise into 1/8-inch-thick slices with a sharp knife or mandoline. In a large bowl, combine the Brussels sprouts, cheddar, flour, thyme and garlic; season with salt and pepper and toss to combine. Transfer the mixture to an 8-inch-square baking dish, packing it in. Pour the heavy cream evenly on top.
In a small bowl, combine the panko, parmesan and olive oil and pour over the Brussels sprout mixture. Bake, uncovered, until the Brussels sprouts are tender, the sauce is bubbling and the top is golden brown, 25 to 30 minutes. Garnish with the parsley.
Photograph by Ryan Liebe
Courtesy of Food Network Magazine
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Get a sneak-peek of the new Food Network recipe page and give us your feedback.See it Now!


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Well hey… I'm glad you stopped by. I'm in the middle of bath time with the babies or trying to throw together dinner because I am terrible at planning meals ahead or I'm reading Skippyjon Jones for the 1,394,283 time. So let's our spirits take a break together, yes?
Do you like coffee? (I'll forgive you if you don't.) I make mine strong.
My little corner of the internet is small, I know, but it's homey. At least I hope you feel at home here. I hope you find some friendship here, some of the good stuff that makes us
feel know we aren't alone. I'll show you around here if you like – bring your mug.
So this is a little personal, a little messy, excuse the clutter. This is a little like walking into my living room on a Monday afternoon. This isn't a Mommy Blog or a Christian Blog or a Homemaking Blog or a Nutritional Blog (ha!) or a Political Blog. This is just me with a cup of coffee and an iPad. I don't have an axe to grind and I'm not selling anything, but I do so appreciate your attention to my heart – do so hope that yours feels safe here.
You might find contradictions – I'm finding that I contradict my younger self a lot so check the date. ;) I'm learning and growing and re-painting the walls frequently so bear with the fresh and scuffed up paint.
And yeah, there's a little dust… I don't write on a schedule (maybe someday) so it can be a bit sporadic here. But I'm around (writing hundreds of drafts that will never get published) so if you fancy conversation or want to leave a jot of your heart here please do. I love learning from fellow travelers.
Oh, and I can get mushygushycorny – like calling us travelers… in life… I'm a bit of a sentimentalist. ;)
So thanks for the company! Keep the mug and come back soon. <3


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December 22, 2013 ( CHICAGO) --Cardinal George marked his golden jubilee with a special mass at Holy Name Cathedral Sunday.
It was 50 years ago this week that the cardinal was ordained a priest.
The ordination happened at his home parish of St. Pascal's on the Northwest Side.
It's now been nearly 17 years since the cardinal has led one of the largest concentrations of Catholics in the nation.
He says no one at the Vatican has so far suggested that he retire.


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Be the first NJ.com user to add photos or videos of Sara Grocery & Deli
It's good i like it it has good snacks and also has nice people that will work with you there subs are good and there deli you can buy thing...
Sara Grocery & Deli is located at 501 N Indiana Ave, Atlantic City, NJ. This location is in the Monroe Park neighborhood. This business specializes in Grocery Stores.


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Key lock switch case modFormer staff writer -
Category: Modding
Today, I'm going to show you how to replace your power switch / button with a key switch. Why would you want to do that, you might ask? Well, why do we put our computers in freezers so we can overclock them more? Why do we spend hundreds of dollars on our case modding? I guess we do it because we love to mod and be unique! Having a key switch, increases the security of your computer and it also makes your case look cool.
Tools needed
First off, we need to round up some tools that we will be needing.
- Screwdriver
- Solder gun
- Solder
- Dremel, rotozip, ect..
- Key switch
- Wire cutters
The procedure
First things first, we need to unplug all wires going to our computer. Next, take your case panel(s) off. Now, you have to make a decision. You can either replace the key switch where your power switch is or you can mount the keyswitch else where. I replaced my power switch with the key switch. If you do choose to install the key switch where your power switch is, you will more than likely need to dremel where your old power switch was, to get the key switch to fit. Needless to say, if you mount the key switch elsewhere, you would still have to cut a hole.
The front of my old power button
The back of my old power button
The picture above is where my old power switch was, and this is also where I had to cut the new hole for the key switch. This was easily done with my cordless dremel, only taking me about 5mins to complete.
(Now, would be a good time to turn your soldering gun on, so it can warm up.) Once you get the hole cut out, put the key lock in the hole and see if it fits. If it doesn't fit, just keep cutting until it does fit.
Here, I was testing to see if the hole I had cut was big enough for the key lock. As you can see in the picture, the cutting of the hole made alot of plastic fragments. This can easily be cleaned up by using compressed air, or "air in a can". It's best to take your front bezel off of your case when cutting. Most all cases allow you to take off the front bezel.
Next, your going to have to find the wire that went from your old power switch to the motherboard. Most of the time it's a white and black wire. It should only be two wires. Once you have located them, cut the old switch off of these two wires. Then, strip the two wires back so they are naked. Now for the fun part :) Whip out your soldering gun, and put a little solder on the ends of these naked wires. It might be a good idea to unplug this wire from the motherboard while you solder, as the wires get really hot when you are soldering. Depending on what type of key switch you have, soldering may differ a little from the pictures. My key switch had brass ends, which made it hard for the solder to attach to. What I did was, put the wires in the holes and then put solder over the two holes.
This is a great security feature and also an easy mod to do! For added security, you may want to put some regular key locks on your case panels. Maybe I will do a guide on that soon. If you have any questions, dont hesitate to email me.


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Most Recent Posts
PAMM Amongst the 2013 Winners of the Miami Knight Arts Challenge
Miami Knights Arts Challenge announced its 2013 winners, PAMM being amongst the group.
Artist Series: Polly Apfelbaum Discusses Mojo Jojo
Artist Polly Apfelbaum talks to PAMM about her influences in creating Mojo Jojo, one of the works in AMERICANA: Formalizing Craft, December 4, 2013 – May 2015. Mojo Jojo is a supervillain, and main antagonist in the Cartoon Network animated series, The Powerpuff Girls.
PAMM Member Preview
Pérez Art Museum Miami members enjoyed a special preview of the museum the evening before its grand opening.
Goldman Sachs Presents "Let's Talk About…What we talk about when we talk about art" with Thom Collins
On November 19, 2013, Museum Circle members were invited to the inaugural "Let's Talk About…," a five-part lecture series featuring director Thom Collins and guest curators at the new Pérez Art Museum Miami for the museum's first member event.
PAMM Contemporaries Art Fair Survival Party Presented by Art Miami and CONTEXT
On November 16, 2013, the PAMM Contemporaries got ready for Miami Art Week at the annual Art Fair Survival Party, presented by Art Miami and CONTEXT at the Gale South Beach.


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I tried this great taco salad recipe from Eat, Shrink and Be Merry. It's called Na-Cho Ordinary Taco Salad. I don't do a lot of meat recipes on this blog but I really enjoyed the meal. Instead of nacho chips, crisp romaine lettuce is used instead. There's beef (I used pork), corn and black beans and some cheese. Below is the recipe I've adapted from the original.
Cooking the meat and the onions only takes about 10 minutes. I recommend having the salad ingredients diced and ready to go before you cook the meat.
The Meat Portion:
- 250-500 mL cups of ground pork
- 1 cup chopped onions
- half can jalapeno peppers (100 mL or to your taste)
- 3 garlic cloves, diced
- 1 tablespoon chilli powder
- 1/3 cup barbecue sauce
- salt and pepper to taste
The Salad:
- I head of romaine lettuce, ripped into pieces and washed
- 1 cup canned corn, drained
- 2 cups canned black beans, drained
- diced peppers
- 1 cup chopped tomatoes
- 1/4 cup shredded old cheddar cheese
- sliced avocado (optional but highly recommended)
- Salsa for the topping
- Brown the pork over medium-high heat.
- In a separate pan, heat the onions until soft, 3-4 minutes. Add the garlic, chilli powder and jalapeno.
- Once the pork is cooked, add it to the vegetables. Add barbecue sauce and salt and pepper.
- Assemble the salad: lettuce first, then the pork and cheese. Add the vegetables and top with salsa.
- Enjoy!


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Going Back to School at My Age
I never thought I would see myself going back to school at my age. I had been married when I was 18, and I was a wife and mother for 22 years. I am still both of those things, but I have a lot more time on my hands now that all three of our children are out on their own. I quickly grew bored staying home and cleaning, even with my occasional outings with friends. It was during one of these outings that my best friend suggested I look into a part time degree in singapore.
She knew how bored I was, and she encouraged me to look at the different programs available. She went the education route rather than the family route when we were younger, so she knew what she was talking about when she said that companies are hiring older workers too. I figured if I went part time, I would still be able to take care of my family and other responsibilities, but I could also embrace a new life for myself too. I looked at the different programs, and I saw where they have an extensive culinary division to the school.
I have spent over half of my life in the kitchen, and my friends and family have all told me that I am an excellent cook. Knowing that I could study culinary arts and get a degree in a field that I already enjoyed so much sparked an interest in me. I read everything I could on it, and I knew that it was where I was meant to be at this stage of my life. It is exciting being back in school, even if I am doing it at a slower pace than others. I feel like I have a new purpose to life, and that is simply thrilling.Continue reading →


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Free Italian Art
Experience Venice
Piazza San Marco or Saint Mark's Square is the main tourist destination in Venice.
Around it are important monuments, elegant historic buildings and expensive cafes, some with live music in the evening. You can hear the music for free as you walk around but sitting at a table is very expensive.
Saint Mark's Basilica, the greatest of Venice's churches, is free to enter. The terrace, museum and chapels have entrance fees.
Rialto Bridge and Rialto Market.
The picturesque and crowded Rialto Bridge has been the main bridge crossing Venice's Grand Canal since 1591. On the bridge are covered arches and shops and on one side is the Rialto Market, a good place to visit in the morning. Go early to see fresh fish being unloaded from the boats.
Many of Venice's fine churches charge an admission fee to cover their costs of upkeep. Others, however, are free to enter. Venice is thronged with churches covering whole centuries of architectural styles, offering great lessons in the history of architecture. They also contain glorious monuments, tombs and paintings by some of history's greatest artists. Below, The Assumption of The Virgin was painted in 1518 by Titian (Tiziano Vecelli) and installed in The Basilica di Santa Maria Gloriosa dei Frari, just called the Frari.
Save money on admission fees.
There are lots of ways to save money on "paying" tourist attractions. Over-65s and under 18s will find State Museums are free to enter, while there are reductions for the under-25s. There are a range of tourist discount cards, and there are various combined tickets for museums and churches. Since July 2014 new rules by MiBAC (the Culture Ministry of the Italian Republic): the National Museums and Archaeological Sites have free admission one day a month (the first Sunday). During Heritage Week, which is usually in May, State Museums are free to enter. The Gallerie dell'Accademia contains masterpieces of Venetian painting up to the 18th century. Below, The Pietà was painted in 1505 by Giovanni Bellini.
Concerts and events.
Free events in Venice are not always well-publicised, but keep an eye on posters around town. Occasionally you'll just stumble across free live music in a piazza or bar. During Heritage Week in May there are free events organised in museums, and by scrutinising the "What's on" leaflet or the "Venice Magazine", available for free, from the tourist office, you might find more cultural initiatives that don't cost anything. Below, during the Carnival there are lots of free entertainments in Saint Mark's Square, as well as lots of costumes to admire.
An other free publication, available from the tourist office, is "Un Ospite di Venezia - A guest in Venice": Events, Museums, Water Transport, Religious Services, Timetables, Theatres & Cinemas, Venice by Night, Hotels, What to Do and How, etc ..
Advice for a cheap holiday.
Venice itself, its canals, bridges, architecture, lagoon and lanes, can be explored and admired totally free. If you want a cheap holiday, I recommend you concentrate your budget on two essentials: accomodation and boat travel. Money can be saved elsewhere, but these are two elements of your holiday that will be crucial to your enjoyment and comfort. You can see Venice on foot but it's tiring and time-consuming and you'll miss some of the city's greatest experiences. Equally, you can save money by staying outside Venice but it simply won't be the same.
Cut your spending on eating: restaurants in Venice are more expensive than in the rest of Italy. If you're prepared to eat snacks and budget meals you'll save lots of money without missing much. Buy picnics and snacks in supermarkets; eat take-away slices of pizza.
Almost free Venice.
Ride on vaporetto. For the price of a vaporetto ticket, you can hop on the slow boat either at the San Marco stop or the stop in front of the train station and take a leisurely "cruise" on the Grand Canal. Bring a sweetheart to snuggle with and it's the best mass transit trip you'll ever take.
The Magic of Venice: San Zaccaria.
The church of San Zaccaria is a large building located just off the waterfront to the south east of Saint Mark's Basilica. It is a very old church dating back to the IX century. Very interesting is the crypt. The walls of the aisles are entirely covered with paintings by Antonio Balestra, Giovanni Bellini, Giandomenico Tiepolo, Antonio Vivarini, Palma the Elder, etc.. Below, the altarpiece by Giovanni Bellini, considered one of the most beautiful and refined works of the master (dated 1505).
Venice: Historic Regatta (for free) on September 2018 (the first sunday).
It is a unique sport and has been practised for more than a thousand years in the Venetian lagoon. In modern times it has become more spectacular due to famous water pageant held before the races: dozens and dozens of multicolours 16th century-style boats, all with oarsmen in period costume, carry the Doge and all the highest ranking Venetian officials, as a true and faithful reconstruction of the glorious past of one of the Mediterranean's most powerful and influential Maritime Republics.
Venice and Veneto Region: unique experience.
Please consider for your next holiday.
Encountering Venice and its Christian roots means discovering a city of the human race. Its charm speaks directly to men and women of every age, culture and religion. The wonder of its beauty is not merely an aesthetic experience. (Angelo Card. Scola Patriarch)
POSTAGE STAMPS are art & culture...!
Why should young people care about stamps? Education, adventure, passion, fun, etc..
CAN YOU HELP..? Wanted used postage stamps for philately promotion to kids (stamp collecting offers a world of interest). All kinds, in duplicates, on paper, are welcome. This is a permanent appeal, so stamps can be sent at any time of the year. Thank you.
Ask gift-offer or visit the blog at
Italian gives free gifts & services
Suggestions to stamp collecting.
How do you start collecting postage stamps? Where to get used stamps from?
It's easy. You can save the stamps from the envelopes & postcards that comes to your place. You can ask your friends and relatives to save the stamps from their mail for you. The one thing I must ask is if stamps could be left on the envelope and cut off leaving about two cm of paper surrounding the stamp, to prevent damage. Trim the excess from around the stamp, but be careful not to cut the stamp. Never pull the stamps from the paper. Thanks for consider a support to my project.
Did you know...?
Italy north-east, a land of history, art, and nature. Monselice, just south of Padua, has an enchanting historical centre. Discover this medieval walled town with my free guided tour. Practice italian language for free. Visit my blog for other details and pictures. Thank you.
Monselice landscape:
The medieval castle at Monselice:
Medieval art in Monselice cathedral:
Hi, greetings, and welcome to my blog. Let me introduce about myself.
My name is Roberto Bortolotto, and I live in Monselice, just south of Padua, Italy.
Arts and entertainment are my passion, and I especially love tourism, philately & postal history, movies, photography, museums.
I can help with whatever you need regarding my area, as public transportation, language, accomodation, lowest cost, etc..
Thanks for reading and be sure to take advantage of my free service.
More images about my area at www.fluidr.com/photos/137443964@N04/
or at www.flickriver.com/photos/137443964@N04/
Below, Michelangelo art on 1961 italian postage stamp:
Experience Italy: Venice, unique vacation.
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I recently switched from Google Chrome to Mozilla Firefox (56.0.1), and images in the Current Listening thread that I post from my Facebook page do not show up, and most from Amazon posted by others are replaced by "Image not available--click to see at Amazon." Is anyone else having this problem? Is it due to a security setting in Firefox? Thanks.
I am using the same version on Win 7, no apparently similar issues. It does sound like a settings issue though...
The amazon picture links are https://.. which means that your browser has to establish a secure link with the amazon picture server. I would also suggest you check your setting.
Page created in 0.022 seconds with 23 queries.


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Mauricio Pochettino: Tottenham will concentrate on own performance
Tottenham boss Mauricio Pochettino wants his players to heed the words of Britney Spears and ignore Arsenal's title challenge this season.
Spurs are on track to finish in the top four for the first time since 2012 but their thunder could be stolen if their bitter north London rivals win the league.
Pochettino, however, is not bothered if the Gunners are crowned champions and quoted Britney Spears' single with Will.I.Am - 'Scream and Shout' - to demonstrate the point.
Tottenham boss Mauricio Pochettino is not interested in Arsenal's title challenge this season.
"I think it's like what Britney Spears and Will.I.Am sing: 'everybody in the club, all eyes on us, all eyes on us'," Pochettino said.
"Because it's not important what Arsenal do. For me it's important to assess our season and how we can compare with us not how we compare with another team.
"If you finish in the top four it's a success because it means we will have improved on last season.
"Expectation can develop depending on how the season goes. But I was confident and I still am confident with the squad that we have."
Tottenham can climb to third on Saturday if they beat Norwich and Manchester City lose at home to Sunderland.
The Boxing Day match at White Hart Lane kicks off the busy Christmas period, which sees Spurs visit in-form Watford 48 hours later, but Pochettino suggested he will not rotate his key players.
"Today it is not a decision to rest them because they are fresh," Pochettino said.
"Last season we played December 26, 28 and January 1 and we didn't change too much.
"It's all about how we assess players after games, if we detect players need to rest maybe we change."
Danny Rose is available again after missing last weekend's win over Southampton through illness while Ryan Mason has also recovered from an ankle injury.
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What happens to my Federal Student Aid (FSA) if I withdraw?By : Kim Murphy | March 1, 2018
FSA at University of Phoenix is awarded for each academic year. The length of an academic year varies by program level, version, and course length.
Students generally receive a disbursement of FSA funds at the start of the program and at the beginning of each payment period thereafter, as long as eligibility criteria are met. There are generally two payment periods in each academic year, each consisting of half the credits and weeks of instructional time in the academic year.
If you withdraw from the university prior to the end of a payment period, a Return of Tile IV (R2T4) calculation must be performed to determine the amount of FSA funds earned as of the date of withdrawal. Any unearned aid for the payment period must be returned to the appropriate FSA program(s).
The amount of FSA earned is calculated by determining the percentage of the payment period completed and applying this percentage to the total amount of aid disbursed and that could have been disbursed for the payment period.
For example, if you completed 39 calendar days in a payment period that is 175 days in length, the percentage of that payment period completed is 22.28 percent. If you were disbursed $6,250 for the payment period, $1,393 of the disbursed FSA was earned. The unearned $4,857 must be returned to its source(s)*.
If institutional charges on your student account - tuition, electronic course materials, refunds of FSA, etc. - exceed the financial aid earned, you will likely have a balance due on your student account that will be your responsibility to pay.
For example, if you had $2,000 in tuition charges, $200 in electronic course materials fees, and a $500 refund in a payment period where you only earned $1,393 in FSA, as in the example above, your balance due would then be $1,307*.
If the percentage of the payment period completed is 60.1 percent or higher, all FSA disbursed and could have been disbursed is considered earned. In this case, there are no unearned funds to return to their source(s).
You can read more about the R2T4 calculation in the Consumer Information Guide.
Please contact Financial Services if you have more questions about the R2T4 process. I am available to assist, as well, at firstname.lastname@example.com.
* The figures provided are examples only; actual amounts may vary for each student.


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Tuesday, March 31, 2009
SRL: Ocean Bottom Seismometers
I got my SRL, and there a few interesting papers. This shows the full underwater installation vehicle. The OBS is the pop can. This one is lucky, since it is beside a big underwater research cable with data and power.
The MARS cable is laid far out in the ocean. This makes it a bit more immune from tsunami-buoy-stealing pirates! If you didn't have that cable, you'd need the Italian job:
This is really cute! I like the fishies!
On another note, there was a paper on Ontario seismicity, an earthquake swarm near Georgian Bay.
I once looked at an OBS for the Great Lakes, but it's rather hopeless without the big power and data cable. As well, you need a big installation digger to try and get it on firm ground. It's generally useless to just plunk it on soft fish-shit! The swarm is interesting. It is exactly the same distance up-fault from the Grenville front, as was the big Burlington swarm from the Hamilton Fault. Of course, these don't exist in the 'real' pay-wall literature, so shhhh!
Posted by Harold Asmis at 1:51 PM
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- November 16, 2014 at 5:54 AM
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Survival Tips
New Products
If you are visiting New Orleans, try to make your reservations at least eight months in advance. Don't come to the city thinking you will get a hotel when you get here–you'll be sleeping in your car, which is not recommended, not to mention rather uncomfortable. Nearby towns with hotels might include: Metairie, Kenner, Covington, Hammond or Slidell. Biloxi, MS and Baton Rouge, LA are 70 miles away, but rooms usually are available there. Book online now
-Do NOT bring expensive jewelry to the city. Do NOT wear it to parades or leave it in your car or hotel room. Utilize your hotel room's safe, if it has one, or bring a piece of luggage that locks in which to place your valuables when you leave the room for the day to go to parades.
-Do NOT leave anything of value in a parked car, van, truck, or RV. If your license plate says "Michigan", you can be sure a thief knows you are traveling with lots of goodies AND that you will be away from your car plenty long enough for them to make off with all of it!
-Don't bring a purse. For one day this is not essential. Leave it at home!
-Fannie packs are "not just for tourists" on Mardi Gras Day! Be sure to bring yours, strap it on tight, and try to tuck it under a jacket or shirt. The best thing you can have is a passport carrier that slides under your clothes, with the least amount of cash and valuables as possible!
-Choose your pants with pickpockets in mind. Don't put your wallet in your back pocket. It's a good idea to carry money in several pockets (PIN cash inside your pocket, and only take out when buying something) and keep your I.D. and maybe one credit card in another. Mardi Gras Day is a "cash" situation. Most places that offer quick food, snacks, and drinks don't accept credit cards. Also, let everyone in your group carry some cash "just in case".
-Does the phrase "Needle in a Haystack" mean anything to you? It will if you get lost! The minute you reach your Mardi Gras destination (the place you will be watching parades) set up a contingency plan in the event someone gets separated. Use a building as a reference point, not a street, because crowds move. Agree on a meeting place, a time, and synchronize your watches!
-*Special Note About Children: Keep them as close to you as possible, and communicate with them before you leave for the day the importance of their staying by your side. Also, make sure they know their whereabouts when you reach your destination- landmarks, etc. It is a GREAT idea to pin a tag on them that tells their name, age, parents names, hotel phone numbers, and your pager/cell phone number if you bring it with you. Know what they are wearing in case you have to ask for help in locating them. It is a scary thing to lose a child during Mardi Gras, and it doesn't happen often, but you have a Police Department that has tons of experience in these matters on your side!
-Follow the crowd. Don't think you will avoid traffic by using side streets you know nothing about. Don't venture off the main roads either on foot or by car. Its best to relax, enjoy the people and the incredible diversity you see, and be safe. There IS safety in numbers so stick with the crowd.
-Please be safe if you drink–alcohol and safety must go hand-in-hand at all times. It is a good idea to stay in control of your person, especially if you are in the French Quarter, where things can happen fast before you even know it. And know this, you are an ideal target for petty thieves if you are intoxicated–especially if you are alone!
-Use your head: know what hotel you are staying at, where it is located, and have some cash on you for a cab ride in case you get separated from your group.
-If you have a rental car, please do not drink and drive, not only because you could get in a serious accident, but because police are on the streets specifically looking for intoxicated drivers. Take beads home with you, not a DUI.('Driving Under the Influence' Ticket)
-Oh, by the way, the drinking age is 21. And it IS enforced.
-And on a lighter note, if you must drink during Mardi Gras, remember that the amount of alcohol you consume is directly correlated with the number of times you must relieve yourself, and bathrooms are not easy to find:)
-Wear comfortable walking shoes. Make sure they are supportive with plenty of cushioning. You'll walk and walk and walk. Also, DO NOT, we repeat, DO NOT wear your new $120 tennis shoes–they will age three years in three days! Bring the old, beat-up pair you wear to do yard work–your shoes will be covered with funk by Ash Wednesday–trust us on this one!
-Dress for comfort, not for style. Weather during Mardi Gras usually varies from 30-90 degrees fahrenheit, so come prepared. It's a good idea to pack a raincoat (small, poncho type) just in case it sprinkles. Just make sure that whatever you wear you can take off if you need to, or put more on for warmth. Comfortable layering is the key, and the look on Mardi Gras Day!
-Wear sunscreen, and try to incorporate a hat in your costume. It's hard to find a shady place on Mardi Gras Day, and though it might be cold in the morning, by midday you might be melting! Use common sense and take the extra minute to watch the forecast for the day!
-Pack snacks and lunch. Bring disposable pre-moistened towelettes. Your hands will get dirty and its hard to find a sink on Mardi Gras. Some people pack an ice chest and use a wagon to haul it around. (Note: Don't do this if you are going to the Quarter. Only do this if you are staying outside of the Quarter to watch the parades. There are too many people in the Quarter to haul a wagon through. It is literally shoulder to shoulder for blocks. It's an experience, and a lot of fun!)
-If you must bring a camera, go for the smallest, lightest, and LEAST expensive. A disposable camera or two is your best bet. Sure, you might want to get high-quality shots from your expensive cam, but you'll lug it around only to find that you can't get any good shots with all the people around you bumping and pushing! Besides, after "holding" everything you own all day, you'll appreciate the fact that you aren't weighed down and remember the incredible things you saw in your memory!
-Bathrooms are few and far between. The song "There Ain't No Place To Pee On Mardi Gras Day" was inspired by a carnival goer. Private restrooms are usually restricted, Port-O-Lets experience heavy traffic and public restrooms are hard to find. Try to locate a place near you that offers restrooms–and if they want $5 per person to use their facilities all day, don't make a fuss, just pay it. It is well worth the money to avoid the discomfort of not having a place to relieve yourself. Also, it is not a good idea to relieve yourself anywhere you please. This is the quickest way to get in [costly] trouble with the law!
-And if you have children that are not 100% potty-trained, put them in pull-ups for the day! If your children are recently trained, put them in pull-ups to start with. It also goes without saying, bring an extra change of clothes in case of an accident:)
-Some notes about costumes: You will be wearing your costume for up to 12 hours, so choose wisely! Full face paint may look great at 10 am, but by 6 pm you will feel like you have mud on your face, and it will feel just as gross. Our advice is to wear a mask–one that you will not cry over if you lose or gets stepped on! If you have a large costume, remember that you will have to transport it with you all day–NOT FUN! Children's costumes are a whole other ballgame. They must be flexible, comfortable, and easy to take on and off! And because the novelty wears off after three or fours hours, we recommend bringing a change of clothes in case your child gets uncomfortable. There is absolutely nothing worse than an irritable, grumpy 8-year-old who is too hot/not happy in his or her costume!
-You will really only see this type of behavior in the French Quarter, where little ones have NO place being, so parents, don't worry about that. Also, thanks to recent publications that have shown Mardi Gras and New Orleans as being a time and place where "anything goes" as far as public nudity is concerned, the New Orleans Police Department has issued a statement that essentially says if you are caught displaying or engaging in this behavior, you WILL be arrested. It will not be a memorable Mardi Gras if you are staring at the walls of a jail cell, so our advice is: don't risk it–have good, clean fun!
-Bring 4 plastic garbage bags, the type with a handle. The amount of trinkets, beads, cups you will catch will amaze you and you'll want to keep everything!
-Do not get in front of floats, or too close to the sides of them. It is not worth the bead, cup, or doubloon to get in an accident with a float that weighs several tons.
-Bring water or a container to hold beverages with a handle or strap that you can put on your body so your hands are free to catch trinkets.
-Remember to step on doubloons before picking them up, if not, your hand might be the one stepped on!
-See everything you can, make some fabulous memories, and remember to scream… "Throw me something, Mister!"


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Two people were arrested tonight suspected in the drive-by shooting of an 18-year-old man on the South Side, police said.
Details were still sketchy late tonight, but Officer JoAnn Taylor said the teen was wounded in the leg around 5:50 p.m. in the 8600 block of South Stony Island Avenue.
She said the suspects may have been arrested in a vehicle possibly used in the shooting.
The gunfire also shattered glass near the gunmen's target, injuring a woman, according to Taylor.
"A lady was injured by shattered glass," said Taylor, who said it was unclear if that woman was taken to a hospital or treated on the scene.


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Moscow 2050 - Urban Greening In this vision I developed some of my ideas, added few lanes of highway add sun shade, moved all transport to the road. This vision explaining that possible to grow many kinds of adible plants in city, it could be a vertical farm on fasads or instalde in few storey hydroponics farm. This will solve the problem of strong annual growth of the population of Moscow, for which you want to expand food production. In this situation, in which the only out-migration from agricultural regions, it is necessary to make the city self-served food. I think that by 2050 the problem will be solved with the rducing of prived transport and use road surface on maximum for farming and leisure.
Link to a page dedicated to the Source of CULTIVATION OF SEAWEED
Link to a page dedicated to the Source of Aquaculture
The same plan, the farm will be located in the air, which will help to approach the problem from all sides.
Link to a page dedicated to the Flying farms
Link to a page dedicated to the Source of Solar shade


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The story of Santa Claus is ancient, but lovely Mia here gives it a new twist. Watch her make you crave for presents as the girl plays in the snow in her white nylon and a tiny red coat which soon reveals her main gifts for us. You will want to get lost among these two generously sized mammary mounds as the girl rejoices in the soft snow.
Kira and sea
Kira is beautiful and full of magic in every possible meaning. Her arcane powers and her erotic appeal will subdue everything around, including the elements – and yourself. Watch her play and dance in her gown which is merciful enough to give you more and more of her full, tight, strong body with every swift, sexy move she makes. Magic!
Sinful Goddess Linsi
The autumn has come, the Mother Nature is about to fall asleep under the soft fluffy blanket of white show – but the youth and beauty of luscious goddess Linsi seems to be never-ending! Watch her walk among the dead leaves and trees all naked – all for you!
Delicious Jessica has fun among tropical plants
Delicious Jessica has fun among tropical plants Imagine yourself on a tropical beach with such a tempting beauty as Jessica playing fully disrobed near the exotic vegetation. Would you build a hut for the two of you to spend the nights together, or would you pay due respect to her sparkling sexiness first? Choose while she keeps playing around!
Alena and Irina and the fireplace
Young, mysterious, even when completely naked, Alena and Irina are about to make that fireplace burn with wild fire as they bring the heat up. Covering each other with caresses, they never forget to expose their breathtaking curves to the camera. Hold your breath and try not to scare the beauties off as they slowly reach for each other's tasty pink.
Angelic Nelly falls from heaven to strip
The day was not bright at all, but luckily we have Nelly here, descending from the heavens to showcase her irresistible beauty of a fallen angel who goes down from heaven and wants to take you straight to hell. Hold your breath as this startling blonde creature reveals her carnal bits and runs her soft hands all over her superiorly smooth body.
Sinful Goddess Kleo
Take a trip into the beauty-soaked wilderness with Kleo, the kind of a nymph available only to the special. See how the heat level is raised fast as the wreath-wearing beauty invites you to a carnival of carnal delights. With our dose of superior photography you'll taste her appeal in full.
Nelly in black and white
Watch sweet Nelly here give her very own dimension to the eternal battle of dark and light. The girl is slim, utterly beautiful, and with a crown of platinum-colored hair on her divine head. This is the light side, and the dark one is represented by her jaw-dropping black latex outfit, full of kinky detail. See her play with it and her smooth, gem-like body.
Sinful Goddess Alice
Beauty is a very dangerous thing – and warrior princess Alice will prove it to you once again. If your heart is brave enough to see her mastering her war skills, then… You will be granted generously in the end of her shoot when she comes unleashed!
Sinful Goddess Mia
Her enemies are afraid of her, her allies are in love with her and her lovers… So far there hasn't been a single mortal who would be capable of admiring her incredible beauty to the fullest! There is nothing able to stop us from watching her in all her glory though!


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Mikaela Shiffrin - golden and diamond fox09. January. 2018
See you in Maribor at 55. Golden Fox, 1.-2. February (Friday&Saturday) 2019!
Mikaela Shiffrin – in a league of her own09. January. 2018
American with a huge lead- A Slovenian surprise, Klara Livk – Maruša Ferk in finals
Duel Shiffrin - Holdener09. January. 2018
Ana Buck with bib 12- Six Slovenians competing – Racecourse intact by rain


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Neil Gaiman Quotes About ArtQuotes about: Art
May your coming year be filled with magic and dreams and good madness. I hope you read some fine books and kiss someone who thinks you're wonderful, and don't forget to make some art -- write or draw or build or sing or live as only you can. And I hope, somewhere in the next year, you surprise yourself.
When things get tough, this is what you should do: Make good art. I'm serious. Husband runs off with a politician -- make good art. Leg crushed and then eaten by a mutated boa constrictor -- make good art. IRS on your trail -- make good art. Cat exploded -- make good art. Someone on the Internet thinks what you're doing is stupid or evil or it's all been done before -- make good art.
When we consider that each of us has only one life to live, isn't it rather tragic to find men and women, with brains capable of comprehending the stars and the planets, talking about the weather; men and women, with hands capable of creating works of art, using those hands only for routine tasks; men and women, capable of independent thought, using their minds as a bowling-alley for popular ideas; men and women, capable of greatness, wallowing in mediocrity; men and women, capable of self-expression, slowly dying a mental death while they babble the confused monotone of the mob?
So that's my wish for you, and all of us, and my wish for myself. Make New Mistakes. Make glorious, amazing mistakes. Make mistakes nobody's ever made before. Don't freeze, don't stop, don't worry that it isn't good enough, or it isn't perfect, whatever it is: art, or love, or work or family or life.
I don't think immediate tragedy is a very good source of art. It can be, but too often it's raw and painful and un-dealt-with. Sometimes art can be a really good escape from the intolerable, and a good place to go when things are bad, but that doesn't mean you have to write directly about the bad thing; sometimes you need to let time pass, and allow the thing that hurts to get covered with layers, and then you take it out, like a pearl, and you make art out of it.
I think you have to accept that an artist also has a relationship with his or her art and his or her fans: you are in an open relationship whether you like it or not. Give the artist room to go into the place they create (literally or metaphorically) . And love them when they can't remember where they put their keys.
When you start out on a career in the arts you have no idea what you are doing. This is great. People who know what they are doing know the rules, and know what is possible and impossible. You do not. And you should not. The rules on what is possible and impossible in the arts were made by people who had not tested the bounds of the possible by going beyond them. And you can. If you don't know it's impossible it's easier to do. And because nobody's done it before, they haven't made up rules to stop anyone doing that again, yet.
They were kissing. Put like that, and you could be forgiven for presuming that this was a normal kiss, all lips and skin and possibly even a little tongue. You'd miss how he smiled, how his eyes glowed. And then, after the kiss was done, how he stood, like a man who had just discovered the art of standing and had figured out how to do it better than anyone else who would ever come along.
Sometimes life is hard. Things go wrong—in life and in love and in business and in friendship and in health and in all the other ways that life can go wrong. And when things get tough, this is what you should do: make good art. . . . Someone on the internet thinks what you're doing is stupid or evil or it's all been done before: make good art. Probably things will work out somehow, eventually time will take the sting away, and it doesn't even matter. Do what only you can do best: make good art.
Neil Gaiman
- Born: November 10, 1960
- Occupation: Author
- Cite this Page: Citation


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63 Bis Rue de Sèvres, 92100 Boulogne-Billancourt
Web :
Contact GFII : Hugues de Mazancourt, Innovation Director
Founded in 2001 as a spin-off of the EADS group, Eptica is a global leader in multichannel and multilingual customer interaction management software, covering the email, web, social media, web chat and agent channels. Its software helps millions of individuals worldwide to have meaningful conversations with businesses, improving the experience and deepening engagement.
Available on premise or as a Software as a Service (SaaS) solution, the Eptica customer engagement platform is designed around a central knowledge base, powerful workflow and Eptica Linguistic Services™, advanced linguistic capabilities that enable organizations to quickly understand the tone, sentiment and context of digital interactions and automatically deliver personalized service, helping to provide a competitive edge over their rivals.
Today, more than 400 organizations across all industries and in 15 countries rely on the power of Eptica's platform when talking to their customers. They include AXA, L'Occitane, Dixons Carphone, Crédit Agricole, Domestic & General, AirAsia, Hastings Direct, TUI, Debenhams, Capita and Ageas Insurance Solutions.
Eptica's continuing innovation and strong performance has resulted in the company's inclusion in Gartner Magic Quadrants for the last five years.


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- Woodworking
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Hand Cream - O'keeffe's
For Dry Hands that Crack & Split!
O Keeffe s Working Hands is a unique formulation of moisturizing ingredients guaranteed to improve dry skin. Tackling severely dry skin from a moisture-based approach was a natural tactic: Parched, barren earth needs water. The same goes for rough, dry skin.
3.4 Oz (96g)


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The District Department of Transportation will begin paving a stretch of South Dakota Avenue NE on Thursday, which will impact traffic in both directions.
The road work, between Riggs Road and Kennedy Street, is the final phase of the intersection reconstruction at South Dakota Avenue and Riggs Road.
At least one lane will remain open in each direction at all times. But while the work is going on, there will be occasional lane closures and traffic pattern shifts on South Dakota Avenue. Signs will direct drivers through this stretch.
Once the paving work has wrapped up, traffic at this intersection will be shifted into its permanent configuration.