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If you're not watching the premiere of Producer like this, you're doing it wrong
Producer is coming exclusively to DramaFever on May 15! Become a fan of the series HERE to receive new episode alerts.
Hey Drama fans! Becca and Megan here with another round of ideas to make your drama viewing experience a little more creative! What is more exciting than bringing together some of Korea's most loved stars for a show all about one of its best pop culture offerings — the variety show?!
We are beyond excited for the premiere of Producer, exclusively on DramaFever, so we put together some fun ideas to make your premiere party extra memorable. Megan even works as a producer at a news station, so we guarantee these ideas are 100% producer-approved! Though we have to admit — no one in the newsroom looks like Kim Soo Hyun!
1. Get into the variety show spirit!
What better way to celebrate the premiere of Producer than by celebrating the ultimate Korean variety show: Running Man? Not only is Mr. Capable himself — Kim Jong Kook — debuting as an actor on Producer, our quartet of leads are working on a variety show. In homage, we created these incredible Running Man-style shirts, by velcroing tabs with everyone's names on the back. If you don't have a Jack-of-All-Trades like Becca around to do the sewing, improvise — you can use white duct tape, even something as simple as paper.
2. Eat like a producer!
Most producers are workaholics and don't have time to stop and eat something healthy for lunch or dinner. We wanted to stay true to the job, so our menu features a well-rounded meal — found exclusively in a vending machine! Chips, candy, soda — it might not be the way to eat all the time, but in honor of our over-worked producers, one night can't hurt! We added some instant ramen for a little more substance — but ordering pizza or burgers to-go is also acceptable. (Don't forget antacids as a parting gift!)
3. Mix it up with some variety-style games…
We researched minute-to-win it type challenges online and came up with a handful to play during breaks. We even personalized them for the occasion — like this round of "Gong Pong" — named in honor of Gong Hyo Jin. Each competitor gets a few ping pong balls and a cup. The challenge: try to be the person who gets the most ping pong balls in the cup in a minute. It's simple, fun, and keeps the energy up.
4. Or go all out — Running Man-style!
You've already got your "authentic" Running Man shirts, so use them just as a decorative nod to the show, or plan your own epic game of hide-and-seek around your neighborhood. You can even set up a capture the flag course in your house. Break into teams and set the rules — then let loose. Every time I watch Running Man, I daydream about how much fun it would be to search across Seoul for a challenge. This way, you can bring a little of the fantasy to your own backyard!
5. Accessorize!
No producer can ever be caught without their name tag. In many places, it doubles as their key card, so it's an essential accessory. For your party, it's a simple and fun souvenir for guests to take home.
6. Stay caffeinated!
Pick your poison. Be it black coffee, energy drinks, or something a little fancier, like Becca's "Cha Tae Latte," it's important to stay alert. Producers can't afford to miss a beat, so a little help from your favorite caffeinated beverage is a must.
7. Carry a clipboard!
A little paperwork is not only authentic — it can also become a fun game to play during the show. Just create a list of common K-drama occurrences — you know the type — the plot lines that keep happening over and over in K-dramas, but no matter how much we roll our eyes, we'd be devastated if they didn't happen at all. We listed a few of our favorites: amnesia, drunken piggy-back ride, mistaken identity...
You get the idea — and we'll play spot-the-trope throughout the show. It's great as the series moves forward. Even if you can't have a get-together for every episode, you and your friends can keep track as the drama moves along!
8. Don't forget to relax!
Remember — you're not at work! Even if Producer is all about navigating the fast-paced world behind the scenes at a variety show, this is your chance to kick back and relax, so do it in style! Do a little role reversal and act like the talent. What better way to look your best for your big debut than by pampering yourself? We bought these Korean sheet face masks online, but you can find fun beauty products at your local pharmacy. Note: Remember to remove any cucumbers from your eyes before trying to watch the show.
9. Invite your friends!
This could be the perfect time to introduce hesitant friends to K-dramas. The variety theme is fun for everyone, and a great gateway into the world of Korean entertainment. Plus, you've got the added bonus of some of Korea's biggest stars coming together on the screen. Lure them in with the junk food and games. They'll likely stay on their own.
10. If the variety theme doesn't do it for you…
Why not pay tribute to K-drama sweetheart Gong Hyo Jin? With her many memorable roles, she's always a drama favorite — just throw together some Pasta, take a style cue from her character in The Master's Sun, and even break out the ding-dong's in honor of her little brother in Greatest Love!
Are you excited for Producer? Make sure you catch the shows premiere tomorrow by becoming a fan of the show HERE to receive new episode alerts! Check out the 7-minute preview below:
DramaFever Premium members will have one-week advance access to new episodes of the show starting with episode 4. Not a Premium member? Upgrade for as little as $0.99/month now!


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Christmas Activity Pack - Great to hand out at a party or to keep the little ones entertained whilst waiting for Christmas dinner.
Each pack folds out to reveal 16 activities including puzzles, dot to dot, spot the difference and colouring pages, as well as a pack of 4 ready-to-use colouring pencils.
Sealed pack size 12 x 12 cm.
Age 3+
Christmas Activity Pack
- Product Code: UT02380
- Quantity in stock: 223
£0.99 each
Prices include VAT at the applicable rate
Royal Mail Standard £2.99 , Royal Mail Express £3.99, 48 Hour Tracked & Signed Courier £5.99
Free Standard delivery when you spend £40, Free courier delivery when you spend £60

subset: commoncrawl


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Social Security will play a critical role in the retirement income for mass affluent investors.
But how can advisors help clients think about Social Security in a strategic way?
Throughout the next week, Bank Investment Consultant will provide tips and insights to help advisors eliminate misconceptions and better leverage this critical asset.
1. Dont panic over reports that Social Security is going Bankrupt
People who warn that the Social Security Trust Fund is projected to run out of money sometime after 2033 often neglect to say that even then, current workers FICA taxes would cover 78% of retiree benefits. And meanwhile, with that date still two decades away, there is plenty of time to fix any shortfall. Example: Eliminating the cap on income subject to the FICA tax.
2. Dont take Social Security benefits too early
The Social Security Administration reports that 76% of retirees these days are opting to start collecting benefits from the program at age 62. This is tossing away a huge amount of income.
As Alicia Munnell, director of Boston Colleges Center for Retirement Research notes, delaying collecting Social Security until age 66, or better yet, 70, is the best single investment an ordinary person can make, since the benefit amount keeps rising each year you wait so that the benefit at 70 is 76% higher than at 62.
Example: A $12,000 benefit at age 62 would be a $16,000 benefit at 66 (not counting annual inflation adjustments), and if taken at age 70 would be $21,120 a year (also not counting inflation adjustments). Munnell argues that even if you need the money, it would generally be better to draw down your IRA or 401(k) balance in order to allow you to postpone collecting Social Security benefits.
3. Social Security benefits are not just for you
Contrary to a common misconception, there is no marriage penalty with Social Security. Both spouses can collect their full benefits. There is, however, often a better alternative if one spouse earned a lot more than the other, and has a much higher Social Security benefit coming: the spousal benefit amount is set at 50% of the higher spouses benefit amount. Thus if a high earning spouse is getting $30,000 a year in Social Security benefits, while the low-earners own earnings only resulted in a $12,000 annual Social Security benefit, that spouse could take a spousal benefit instead of $15,000 a year.
4. Social Security has a death benefit, which makes waiting to collect all the more important
When a higher-earning spouse dies, the surviving spouse starts receiving a widows benefit that is 100% of the deceased spouses Social Security benefit. Thats a good reason for the higher earning spouse to wait until age 70 to start collecting benefits. Where else can you get an annuity like that with an inflation clause linked (so far at least), one-to-one to the Consumer Price Index?
There is a 50/50 chance that one spouse, usually the wife, will live to be 90, so this is an important point to consider.
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Quick Reference
Cartilage with an amorphous, unstructured matrix containing elastic fibres in addition to chondrocytes. Elastic cartilage supports the pinna (outer ear), maintaining its structure, while allowing it to be flexible.
elastic cartilage
Subjects: Sports and Exercise Medicine.
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2009-2016 Harley Touring Billet Cat 2:1 Full System
2009-2016 Harley Touring Billet Cat 2:1 Full System
Year: 2009-2016
Make: Harley Davidson
Product Number: 627Z-31-32 and 630-21-32
New Billet Cat designed for Interchangeable
Billet Cat Sold without End Cap's
End Caps Sold Separately
Billet Cat Retail Price
627Z-32T Chrome 627Z-31T Black
Chrome $1,099.00 Black $1,249.00
Billet Ghost Retail Price
630-32TG Chrome 630-31TG Black
Chrome $389.00 Black $459.00
2009-2016 Harley-Davidson FLH / FLT D&D 2 into 1 Billet Cat Exhaust pipe. 2:1 Billet Cat is a stepped header system at the head 1 5/8" to 1 3/4" to 1 7/8" at collector and and 2 1/2" where the muffler goes to the header.
All Billet Cat full systems a equipped with heat shields, exhaust gaskets, bolt kit and a baffle. Each exhaust system is designed and dyno tested at our facilities. All of our testing is done with that Harley SE Race Tuner. Every exhaust is designed to increase low-end torque and horsepower. Performance increases are about up to 15% with the proper tune on the bike.
The 2 1/2" Vortex wrapped baffle core is for motors 96" to 113". Muffler housing is 4".
The Billet Cat comes with both 12mm and 18mm 02 bungs to fit bikes 2009-2016.
Note: Blueing and Discoloration are caused by Improper Tuning and will not be covered under Warranty.
Notice: D&D Performance Exhaust Systems are designed for closed course racing applications only. Not for use on pollution controlled vehicles.Finish Options:
- Chrome and Ceramic Black


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Go Back: Home
Next Steps for the GMO Labeling Movement
With each attempt, the public becomes more educated about this issue
The final result from Washington State's ballot initiative to label genetically-engineered foods was painfully close. A mere two percentage points (38,000 voters) made the difference between yes and no. Similarly, last year in California, the Yes side lost by a narrow margin.…
» Read more
(3) Comments
by: Michelle Simon – December 13, 2013
Connecticut Legislature Moves to Label GMO Foods
Law is first of its kind in the United States
This week, Connecticut won the honor of becoming the first state to pass a law requiring genetically engineered foods to be labeled. (The governor has indicated he will sign.) It was really only a matter of time. The disappointing defeat of Prop…
» Read more
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by: Michelle Simon – June 6, 2013


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Cars & Coffee
Saturday, August 18, 2018
Education & Exhibit Plaza
Share your passion; fellowship with people of common interest. Open to all vehicles — classic, exotic, muscle, and favorite car. Enjoy free coffee and donuts with other car enthusiast.
Thanks to various contributions through fundraisers and generous donations, the Auburn Cord Duesenberg Automobile Museum is able to offer and reach out as a proud member of the community — thank you for your support.
Sponsored by:


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Mary's Hill Lodge - Reader Reports & Opinion
These reports are a combination of questions and comment posted in our Mary's Hill Lodge forum and visitor reports added via the 'Add Report' tab above. The votes awarded are weighted by volume and date to give a truer representation of reader satisfaction [more details].
Reader Satisfaction Ranking: Weighted ranking based on 54 votes = 4.9 (max 5)
Guest Report
Marsha Seetal Marajh from Trinidad visited in April 2017 and awarded
Our stay at Mary's hill lodge was very satisfying. The house is very family orientated and is equipped with all items needed such as pots, pans, glasses and towels. The pool was appropriate for the kids also as there were a shallow end and a deep end for the adults. We enjoyed our stay very much and would surely visit again.
Guest Report
Shalini Jattan from Trinidad visited in August 2016 and awarded
Quiet, peaceful and safe area. Satisfactory amenities. You take a small step back in time with the rustic beauty of the lodge with some modern amenities. Recommended for groups looking to get away from the city life and wanting a more country style relaxed holiday.
Guest Report
Marsha Phillip from Trinidad visited in August 2016 and awarded
I recently returned from Mary's Hill Lodge. My heart is breaking......I do so want to go back!! It was just as described by the previous reveiewers. The place was everything I wanted in a vacation "home". Cool, peaceful, quiet, breezy and with a pool. We thoroughly enjoyed waking up to the sounds of the birds and goats.
There was a kitchen that was outfitted with everything needed ....except a rolling pin/bilna, dabla and a tawah/platin. But I did not make that a problem....I was able to improvise.
My kids loved the pool and we all enjoyed swimming under the stars in the consistently warm pool water. They also loved playing eith the boardgames that were thoughtfully providex.
Laura,Sandra and Sian were all,polite, warm , helpful and friendly. I CANNOT WAIT TO RETURN!!!
Guest Report
Reesha from Trinidad visited in July 2016 and awarded
Mary's Hill Lodge is absolutely wonderful for a private getaway. It's spacious with adequate amenities leaving you to want for nothing. The pool is well-maintained as well. The lodge allows for privacy and there are no disturbances as the area is quiet. The house itself is well-furnished and very cozy, like a home away from home. This is my second stay and I highly recommend the lodge to anyone looking for a place to stay in Tobago.
Guest Report
Michael And Cilla Stubbs from U.K. visited in June 2016 and awarded
We stayed at Mary's Hill Lodge for two weeks from 24 June until 08 July 2016. The photographs on the website do not do the house justice, it is fantastic. We found everything extremely comfortable and very well equipped. The pool area was great and looked really good at night when the pool lights were on. We loved it so much, we have now booked another stay next May for three weeks just days after returning home...absolutely no fault could be found with the property and the gardens were really beautiful and well maintained. We had no young children with us but we were impressed with the safety features in place to stop them from leaving the patio area.
As a footnote, the daily battle of wills between our car and the billy goat tied up on the driveway up to the house was amusing but, in the end, we won...most of the time.
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Eminence Speaker Shootout Video
Eminence Patriot Speaker vs Eminence Red Coat Tonespotter Speaker
The guitar is a Stratocaster with Fender Fat 50 Pickups through a Ceriatone Overtone Special 50 Watt Head.
The sound samples are recorded guitar loops through a RC-30 Loopstation to keep the consistency in the the playing and recording. Both samples are just off center with a SM-57 instrument microphone.
A huge thanks to Brian for lending me his 2×12 cabinet with fitted these two awesome speakers! Thanks mate!


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Walking Dead's Greg Nicotero Hints at More Character Deaths
Even when The Walking Dead isn't airing new episodes, it seems like all people want to talk about. First, the series lost its second showrunner Glen Mazzara, then we heard that the first two seasons would be presented in black and white to more accurately reflect the comics. Now we're getting all kinds of promo material for the Feb. 10 midseason return. The Hollywood Reporter got in on the undead action by talking to co-executive producer Greg Nicotero and actress Laurie Holden.
"We've established a certain scenario on our show where nobody is safe — and certainly in the back-half of our season, it doesn't get easy for anybody," Nicotero said. "We have the whole Woodbury community with the Governor [David Morrissey] and our principal cast. We'll probably end our season minus a cast member or two."
Nicotero also addressed the idea of the impending war between Rick's crew and the Governor's while the former tries to save Daryl from the latter. "[The fight] moves around a lot," he said. "It's very possible there might be another attack on Woodbury. The beauty is you're not confined to one location, even though we spend a lot of our season at Woodbury or the prison. The bottom line is that we've established the conflict between the Governor and Rick, and we'll explore that a lot more in the second half."
THR also spoke with Holden, who plays Andrea. about her character realizing her relationship with the Governor might not be all she thought it was. "Andrea's eyes are now opening; she had no idea that Rick and the others were still alive," Holden said. "Now she's learning that the group is not only alive but that one of her friends has been captured by the man she's been romantically involved with. Her head is exploding."
Holden also said viewers will see a new Governor when the season returns, and that her character's heart will be in the right place when she finds out about her former group hanging out in the prison. She also addressed Andrea's potential ability to help Daryl. "It's not so easy; she is in a town where it's guarded and the Governor has men who have disarmed everybody," Holden said. "Woodbury almost becomes a cage, like its own prison, in the second part of the season. Andrea is going to do anything and everything she can to protect the people she loves."
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I am a result oriented, customer-focused, articulate and analytical Software developer, having more than 15 years of experience, strong in design, Analysis and integration, with great problem solving skills. I am an expert in LAMP/WAMP, skilled in developing business plans, requirements specifications, team management and architectural system's research, strong written and verbal communications. I am interested in a challenging career in Application Development and Distributed Systems.
My key strengths are:
- Expert in: PHP 4 & 5, MySQL, JavaScript, HTML, CSS, C#, .NET.
- Familiar with: C, C++, Visual C++, Java, SQL, Microsoft SharePoint.
- Working experience in CMS and PHP frameworks: WordPress, Smarty, Kohana, CodeIgniter, Laravel, Phalcon, Yii.
- Good concepts of object oriented programming and data structures.
- A self starter.
- Good team member.
- Strong in system design.
- Strong in database design.
- I like to learn new things and improve my skills.
- I have successfully designed and developed professional web applications.
- I have successfully managed software development teams.
- I have successfully trained junior developers.
- I hate documentation but still I have successfully written project documentation for different projects.
Professional Experience:
Head of Engineering at iCarAsia Limited (Malaysia)
April 2014 - Present
Senior/Lead Software Engineer at A & T
June 2011 - April 2014
Senior/Lead Software Engineer at KalSoft
April 2011 - June 2011
Senior Software Engineer at Television Media Network (Express News)
October 2009 - April 2011
- http://tribune.com.pk
- http://blogs.tribune.com.pk
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- http://www.express.com.pk
Senior Software Developer / Team Lead at ePlanet communications
June 2009 - October 2009
Technology Team Lead / Project Manager at HireLabs Inc
June 2008 - May 2009
Senior Software Engineer / Team Lead at Infinilogic Private Limited
September 2003 - May 2008
- http://www.formationshouse.com
- http://www.graphics4less.com
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Academic Qualifications:
MS (Software Engineering) from Hamdard University of Karachi
2005 - 2007
BS (Computer Science) from Petroman Institue of Karachi
1999 - 2003
Personal Information:
+60 16 288 8397


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How will you travel to work in 2040?
The future commute, from self-driving autos to flying city vehicles
The future commute, from self-driving autos to flying city vehicles
As violence against women in India continues to make headlines, lawmakers and local developers are responding to pressures for better city infrastructure.
Whether you use a VPN for privacy or Modern Family, Netflix's recent VPN crackdown is blocking more and more users from their binge watching needs. Should you try to get around it?
In England, artisanal food and drink have become almost commonplace. From rare-breed meats to regional cheese and cider, visitors have Continue reading
Just how much data is there about you online? Before you answer that, think about the slew ofsocial media networks, Continue reading
Originally written for CNN From boxed sandwiches and salads in plastic tubs to fine dining. The world's gastronomic masters are Continue reading
Originally written for Techlicious.com We're all used to seeing "Log in with Facebook" or "Log in with Google" at sites Continue reading
About a year ago, the trend shifted from pop-up restaurants to pop-ups that actually wanted a bricks and mortar permanent Continue reading
The iPhone 5 might have been a letdown (albeit a thinner, lighter one), but I still think Passbook, the most Continue reading
Federal agents now have even greater scope for spying on computers belonging to regular citizens, thanks to a controversial amendment Continue reading
We use our smartphones in place of maps,health trackers and cameras, so why not use them to replace our credit Continue reading
Originally published at Techlicious.com Internet users are pushing back against the National Strategy for Trusted Identities in Cyberspace (NSTIC) initiative, a Continue reading


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The Interview.........
What do you make? I make all kind of stuff such as pillows, tote bags, pouches, stationary and prints.
What is your favorite piece from your own shop? I really like my birdie desk calendar.
If you could buy anything on Etsy, what would it be? I would like to get a Vintage Cherry Bench from sprucehome.
What made you start making your item? I grew up around my father's shoe factory. I think once my parents saw that I loved to draw they encouraged that in me. I've always wanted to be an illustrator or a designer. I like using different kind of materials for my work.
Do you have a favorite purchase or two? I love my boston terrier mini pillow that I bought from MODESTO. I have a boston terrier, named seven.
GIVEAWAY TIME! Joom has decided to give one of her mini pillows (any color from her shop) away for this giveaway )! To enter all you have to do is comment here and tell us what is your favorite piece from Joom's shop (http://www.joom.etsy.com/) is! For additonal entries, follow me on twitter or on blogger and let me know if you already do.


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Regular customers
Become regular customer of PYRONALE!
- As a regular customer you can book your tickets directly from us – the organizer and save the advanced booking fee (15 %)
- You benefit from our additional discount campaigns, we exclusively offer our regular customers.
- You buy your ticket directly from the organizer. Your benefit: Our contributors advise you individually and reserve the best seats for our regular customers
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How to become regular customer:
Please click link belowRegular customers form
Jacky Dunkel
Tel.: 0049 (0)30 31 575 413
Jacky Dunkel
Tel.: 0049 (0)30 31 575 413


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Soybean checkoff-funded research shows U.S. soybean farmers remain committed to sustainably increasing production in order to meet growing global demand for food. The United Soybean Board (USB) and soybean checkoff will co-sponsor the American Soybean Association's (ASA's) Conservation Legacy Awards as a way of recognizing U.S. soybean farmers who demonstrate outstanding environmental and conservation achievements. In addition, Monsanto, BASF and Corn & Soybean Digest are sponsors.
The awards honor farmers whose practices are both environmentally friendly and profitable at the same time. USB invites U.S. soybean farmers to register for the award by Aug. 5. For more information or to submit an application, click here.
David Wilson, team lead of USB's Sustainability Initiative and a soybean farmer from Lincoln, AL, believes the majority of U.S. soybean farmers operate sustainably now. He says awards like this one can help highlight those efforts to people outside of agriculture.
"To me, this is one of the most important awards given out every year, because it highlights farmers' efforts to people outside of agriculture, not just to our fellow farmers," Wilson says. "Sustainability should be the first thing on every farmer's mind, from conservation to crop protection products to tillage to the crops and the rotations that he or she plants."
USB created its Sustainability Initiative to help improve the environmental footprint of the entire U.S. soybean industry. That task begins with raising awareness among U.S. soybean farmers on why sustainability is important.
Past checkoff surveys show a majority of U.S. soybean farmers believe they're the environmental stewards of the land and have adopted sustainable farming practices.
Additionally, the checkoff funds studies, such as one conducted by the Council for Agricultural Science and Technology, that show soybean production is environmentally sustainable.
Conservation Legacy Award winners will be selected based on three criteria: cropland management practices, farmstead protection and conservation and environmental management. Awards will be given to farmers from three regions: Midwest, Northeast and South. The three winners will all receive expense-paid trips to next year's Commodity Classic, where the national winner will be announced.


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5 Tips How to Write a Compelling Summary for Your LinkedIn Profile
Posted on Jun 24, 2010 in LinkedIn • Social MediaMost LInkedIn users will know that the summary is possibly one of the most important parts in their LinkedIn profiles. Some people sign up for LinkedIn, quickly assign a profile picture, slap on their website URLs and add a couple of lines about what they do for a living. However, these people are missing the point here, and are not doing enough to 'sell' themselves. Having a LinkedIn profile is all about expanding your business network, and your summary is a vital catalyst for you to achieve your goals using this popular social networking.Here are the best 5 tips on how to write an engaging summary for your LinkedIn profile.
1. Think of your summary as a game expansionTo properly 'sell' myself, I always think of my headline as a best-selling game, and the body of the summary its expansion pack! What you do is attract people with your best points in your headline, basically put your best foot forward – and then WHAM! Pile on all your unique selling points (USPs) in your summary and get people hooked on to you as a talented professional.Why do you think people keep getting one expansion pack after the other, especially for those The Sims games that sell like hot cakes all the time? :-)Then there is the fact vs. fancy debate – Whether you want your summary to contain boring but true facts, OR inspirational quotes that tell people about what sort of person you are but not the talents you may possess?
2. Be interesting. Be very, very interestingAccording to Shoestring Branding the summary space in your LinkedIn profile should be treated like your elevator pitch but you should ALWAYS refrain from writing in a boring manner. And that means NO big words, NO jargon, and absolutely NO phrases that sounds like an automatic mission statement generator.You can also try your hand at writing a light-hearted summary that will make people sit up and pay attention. Humor is appreciated but only when it is tasteful!
3. Sprinkle powerful and attention-grabbing words in your summaryGil Carlson from Freelance-Copy-writing.com has a list of uplifting words for your perusal. Normally copywriters would craftily dangle these words in front of potential customers when strewn across the sales page, but I think there's no harm in using them sparingly when it comes to 'selling' yourself on your LinkedIn profile. Here are some of the better words you can use:
- Challenge i.e. "I love challenges and will rise to the occasion to make my endeavors a success."
- Creativity i.e. "I've been told that creativity is one of my best traits."
- Inspiration i.e. "I find inspiration in simple everyday things found around us."
- Vitality i.e. "I have the vitality of ten hares when it comes to completing important tasks at hand."
- And the most popular yet powerful word – Love, i.e. "I love life – and it loves me back."


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Bloomberg View:
Republican presidential candidate Mitt Romney has one potential response to working Americans angered by the 14.1 percent federal income tax rate he paid in 2011: If elected, he would lower taxes for everybody.
Or would he?
As Romney tries to project a kinder, gentler image to voters, we're going to hear a lot about how regular families will benefit from his policies. A central part of his charm offensive will be his proposal to cut tax rates by a fifth.
Problem is, Romney has also promised that his tax reforms will be revenue neutral. This means the government will take the same number of dollar bills out of our collective wallets. Although tax rates might fall by a fifth, the tax burden won't change. It will simply be rearranged.
More from Bloomberg View:
- We Would Be Better Off Had Romney Been President
- Why Obama's Money Is Worth More Than Romney's
Romney's proposal is a standard prescription among budget wonks: "Lower the rates, broaden the base." In other words, he plans to take a smaller share of each dollar of income, but make more of that income taxable. He could achieve that, for example, by limiting deductions such as those for mortgage interest, retirement savings or charitable contributions. (Romney used the charitable-contribution deduction to reduce his taxable income by $2.25 million in 2011.)
Traditional Argument
The traditional Republican argument for tax cuts is that people will work more, and hence boost the economy, if marginal rates are lower -- that is, if people get to keep a larger share of each extra dollar they earn. In the extreme version of this story, made popular when marginal tax rates were as high as 70 percent, cuts might even lead people to work so much more that the government gets just as much revenue from them as it would with the higher rates. No serious economist actually believes cuts in current rates could increase revenue, but most agree that a reduction in the marginal tax burden increases the incentive to work.
The Republican enthusiasm for tax cuts, though, doesn't apply to Romney's reform. That's because his plan tinkers with statutory tax rates (the rates written in the law), while the loss of deductions will probably leave unchanged marginal effective rates (the share of each extra dollar in income we actually pay). This point has been made forcefully by Alex Brill and Alan Viard, both economists at the right-leaning American Enterprise Institute, who wrote that "lowering statutory tax rates while broadening the income tax base generally does not reduce work disincentives because it leaves the relevant effective tax rates unchanged."
To be sure, outcomes would be different for individual families. Currently, if you buy a better health-care plan or a bigger house or if you put more of your money in tax deferred savings, the dollars you spend on these items are excluded from your taxable income. If Romney limits any of these deductions, families that depend on them heavily (most likely the middle class) could end up with a higher marginal tax burden, while families that never used them could be taxed less. As a result, some might get a stronger incentive to work, while others might face a weaker incentive.
We don't know the implications for your family, because Romney has refused to spell out just what base-broadening changes would offset the lower statutory rates. Those who want more specifics from Romney on his tax plan are right to keep pressing him. He's proposing a large-scale redistribution of income without saying who will gain and who will lose. In such an opaque situation, it's reasonable for a cautious voter to assume the worst.
Perverse Incentives
Reforming our tax system remains an important priority. Broadening the tax base is central to many proposals, including those of the Simpson-Bowles deficit reduction commission, the Domenici-Rivlin debt reduction task force and President Barack Obama. The logic of these reforms is that, whether or not we want to raise more revenue, we should eliminate the perverse incentives our tax code creates -- for example, by rewarding people for taking on debt to buy a house. Eliminating deductions would eliminate the distortions.
Romney's rationale for tax reform seems to be based on a more cynical political logic. He is campaigning on the parts of his plan that would lower voters' tax burden, while hoping they'll forget about the equal and opposite parts that will raise it. In reality, he's not planning to cut taxes at all.
(Betsey Stevenson is an associate professor of public policy at the University of Michigan. Justin Wolfers is an associate professor of business and public policy at the University of Pennsylvania, and a non-resident senior fellow of the Brookings Institution. Both are Bloomberg View columnists. The opinions expressed are their own.)
Read more opinion online from Bloomberg View. Subscribe to receive a daily e-mail highlighting new View editorials, columns and op-ed articles.
Today's highlights: the editors on why GM must remain Government Motors awhile longer, on making air conditioners more green and on why Europe must get its banking union back on track; William D. Cohan on JPMorgan's missing $6 billion; Albert R. Hunt on the best way to handle Iran; Jeff Rubin on the end of growth; Luigi Zingales on why Romney would have done better than Obama.
To contact the writers of this article: Justin Wolfers at email@example.com Betsey Stevenson at email@example.com.
To contact the editor responsible for this article: Mark Whitehouse at email@example.com.


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ISO Burner v.8.5
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ISO Burner is an easy-to-use and powerful ISO Burner to burn MP3, DATA, ISO, AUDIOS, VIDEOS, and IMAGES to high-quality CDs or DVDs .
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- Release Date:06/08/2013
- License:Shareware
- Category:Players
- Developer:Abdio Software Inc
- Trial length:7 Day Trial
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- Size:3.43 Mb
- Price: $29.95
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text:
|Device and method for pregnancy detection
|Corti et al.
|Lateral flow chromatographic binding assay device
|Gordon et al.
|Lateral flow, non-bibulous membrane assay protocols
|Eisinger et al.
|Membrane-supported immunoassays
(a) a substantially fluid-tight housing having an entry and first and second display ports therein, said entry port for addition of fluid sample to the housing and, said entry and display ports being in fluid communication with one another by means of capillary action through at least one porous membrane, said housing further having a floor divided into two planes, wherein one end of said floor is in a substantially lower but parallel plane to the other end of said floor;
(b) a slope separating the two planes of the housing floor, wherein the slope is at an angle which is sufficient to slow the passage of fluid sample through the porous membrane;
(c) a first porous membrane disposed along the lower end of the housing floor in fluid communication with said entry port to which is movably bound a first antiligand complementary to the ligands of interest suspected of existing in the fluid sample, said first antiligand is bound to a label capable of producing a detectable signal indicative of the presence of ligand(s) of interest in the fluid sample;
(d) a second, porous membrane disposed along the higher end of the housing floor in fluid communication with the first, porous membrane, to which the second, porous membrane is immovably bound:
(i) one or more second antiligands complementary to the ligands of interest in the fluid sample, said second antiligands being bound beneath said first display port; and
(ii) first ligands complementary to said first antiligands, said first ligands being bound immovably beneath said second display port;
(e) one or more fluid gulleys in the higher end of the housing floor to capture excess sample fluid from the second, porous membrane; and
(f) an absorbent means in fluid communication with said second porous membrane for capturing excess fluid sample from said second porous membrane.
a) adding said fluid sample to the apparatus according to claim 1 through the entry port of said apparatus,
b) allowing said fluid sample to migrate past the first and second display ports of said apparatus, and
c) comparing any color change mediated by said label or absence thereof displayed through said first display port to the color change mediated by said label displayed through said second display port to determine if the display visible through said first port is identical to or different from the display visible through said second port, wherein an identical color change in the first and second display ports indicates the presence of analyte, a color change in the second display port and no color change in the first display indicates no analyte, and different color changes in the first and second display ports indicates a compromised assay.
1. Field of Invention
This invention relates to one-step methods for conducting assays of fluids suspected of containing selected ligands. It further relates to an apparatus for conducting these assays.
2. Description of the Prior Art
In recent years, immunoassay procedures have undergone nearly continuous refinement in an effort to simplify and speed the process of detecting selected ligands in fluids suspected of containing them (these fluids will hereafter be referred to as analyte samples). As a result of this work, assays using monoclonal antibodies which recognize different epitopic sites on an antigen have been developed which made it possible to conduct simultaneous assays without repeated incubation and washing of bound antibody.
One example of such a process can be found in U.S. Pat. No. 4,632,901. In the method of that patent, a liquid sample suspected of containing an antigen of interest is poured onto a porous material to which an antibody capable of binding the antigen of interest is coupled. Through capillary action of an absorbent material in contact with the porous material, the sample is drawn in a directed fashion through the porous material and past the coupled antibody. Antigen in the sample will be captured by, and will bind with, the coupled antibody.
After this first step is completed, a second step is taken wherein a separate solution of labelled antibody is passed through the porous material so as to bind to the antigens which are now bound to coupled antibody. Unbound labelled antibody is then flushed from the porous member by a washing step, which may be followed by an incubation period. Finally, a third solution containing substrate reactive with the label on the antibody of the second solution is added to cause a visible color change indicative of the presence of the antigen of interest. To facilitate accurate performance of this method, an apparatus is provided which funnels sample through to the absorbent member which, by capillary action, will pull the sample through the device and, in one embodiment, out of its bottom.
Similar to the three step method of U.S. Pat. No. 4,632,901 is the dipstick method of U.S. Pat. No. 4,366,241. In the dipstick method, the assay device is a strip on which an immunological ligand is bound. The strip is dipped into or otherwise contacted with the analyte sample, then successively contacted one or more separate solutions which may contain a labelled antiligand, enzyme substrate (for enzyme labels) and/or washing fluids to remove any unbound label. A filtration step may also be taken to facilitate complete washing (see, e.g., U.S. Pat. No. 4,623,461). Other researchers have suggested the use of a second control assay for verification of the assay results (see, e.g., U.S. Pat. No. 4,200,690 [method provided for analyzing fecal samples using two washing and incubating steps]).
For a similar dipstick device with both labelled and unlabeled antibody bound to the sample-receiving porous material (see PCT Application No. PCT/GB88/0322).
While the developments described above have provided compact, relatively efficient means for performing assays, several problems with the presently known procedures remain. First, after addition of the analyte sample to the assay device, these procedures require the addition or use of one or more additional solutions to complete the assay. As each solution is added to the device, or each device dipped into successive solutions, the opportunities for spillage or contact between the solution(s) and the user are enhanced. This problem is further worsened in assays which require the user to remove a portion of the device (such as a viewing port) during the procedure.
Multiple dipping or pouring steps present not only a possible loss of sensitivity of the assay (through loss of reagent solutions), but also an aesthetic and hygienic problem for the analyst. Consumers in particular are likely to be intimidated by the need to mix and add one or more solutions during the procedure, if not put-off altogether by the prospect of contacting the analyte sample (which is usually urine in consumer assays such as pregnancy tests).
Another consideration is how accurately the results of the assay are reported. Chromatographic devices are becoming more common in recent years. For example, U.S. Pat. Nos. 4,094,647, 4,235,601 and 4,361,537 describe test strip devices where different zones in the strip contain reagents needed to produce a detectable signal as analyte passes into or through the zones.
A variation on the strip devices described above requires the user to apply a second ligand containing fluid to the device after application of the analyte sample. A fluorescent or enzymatic label is covalently bound to the ligand in the second fluid; the ligand is specific to the analyte of interest and will bind thereto, allowing its detection on activation of the bound label. This and similar devices (see, e.g., U.S. Pat. No. 4,740,468) suffer to some extent from the same shortcoming as the devices which require washing and incubation steps; the need to use more than one solution at the correct time and in the correct order to perform the assay.
One effort to avoid the need for addition of reagent solutions found in prior art devices is reflected in U.S. Pat. No. 5,075,078. This patent describes several embodiments of chromatographic test strip devices which use a visually detectible result format generating plus (+) or minus (-) signs to indicate, respectively, the presence or absence of the analyte of interest in the sample.
In particular, the '078 devices are directed to solving the problem of "leading edge effects" i.e., where the plus or minus sign is not clearly or completely formed, causing the test results to be inconsistent or unreadable. To explain, conventional plus/minus assay devices include a chromatographic substrate of absorbent material. A test region will be located on the substrate, in which is located a procedural control bar parallel to the direction of fluid flow through the substrate and a patient test bar perpendicular to the control bar. Typically, a ligand specific to the analyte of interest will be bound within the test bar which will capture analyte present in the sample fluid. A label reagent is added to the device after addition of the analyte sample fluid; alternatively, the label reagent may be added with the sample fluid.
If the analyte of interest is present in the sample fluid, the label reagent will react with it in the test bar and with a corresponding ligand in the control bar, forming a plus sign. In absence of the analyte of interest, the label reagent will react only with the ligand bound in the control bar, forming a minus sign. However, experience with these prior art devices has shown that several failures can occur which produce misleading test results. For example, depletion of ligand in the control bar can prevent binding of label in that area, causing only part of the minus sign to appear. Another failure is caused by a solvent front which causes the edges of the control and/or test bars to become blurred; it is this phenomenon which is commonly referred to as a leading edge effect.
The plus/minus devices of the '078 patent attempt to avoid these failures by placing the control and test bars at a preferred 45° angle to the direction of fluid flow and at a 90° angle with respect to each other. A diffusible label application pad is included in the device which includes a label conjugated to a ligand (generally, an antibody). The device is described as being "self-performing" (i.e., requiring only the addition of analyte sample fluid to perform the test) and as producing clear test results (due to the orientation of the test and control bars, which is intended to minimize the distance the sample fluid must travel, thus limiting the opportunity for leading edge effects to affect the test results).
However, whether or not leading edge effects are controlled by the '078 patent's orientation of the control and test bars, the possibility for misleading results is still inherent in the device. Specifically, placement of the displays for positive and negative test results on the same region of the substrate by definition allows for the two results to be confused. Accordingly, a test device which provides for separate test result displays which cannot be confused is still needed in the art. Further, the device must still be user-friendly; i.e., require a minimum of steps to perform and allow those steps to be performed in a simple, hygienic manner. These needs are addressed by the present invention.
The present invention overcomes the limitations of prior assay procedures and devices and provides a method and device for performing simple, clean and accurate analyte assays.
These results are accomplished in the present invention by means summarized as follows:
The apparatus of the present invention comprises a closed container, preferably made of a nonporous plastic, such as the commercially available plastic "ABS" supplied by the Monsanto Company of St. Louis, Mo., in which a sample entry port and two display ports. The housing may be formed in two pieces, the first being a ported cover and the second being the floor, a portion of which is raised to form a membrane platform.
The sample entry port leads to a chamber in the housing in which a porous membrane having fibers therein of any orientation (preferably fiberglass) is disposed. The membrane extends upwardly out of the chamber, where it contacts a second porous membrane which is affixed to a platform extending substantially along the remaining length of the housing. At the end of the platform an absorbent pad may be present to collect excess sample fluid.
A soluble antiligand corresponding to the analyte of interest is coupled to the first porous membrane. This antiligand is conjugated to a label, preferably a metal label and most preferably colloidal gold. A second immobilized antiligand corresponding to the analyte of interest is coupled to the second porous membrane and positioned beneath the first of the two display ports. An immobilized ligand corresponding to the first antiligand is coupled to the second membrane and positioned apart from the second antiligand and beneath the second of the two display ports. The first soluble antiligand serves as a label reagent; the second immobilized antiligand serves as a patient test region, and the immobilized ligand serves as a procedural control region.
The assay is performed in a single step. An amount of analyte sample is dropped or poured into the sample port. All or most of the sample proceeds by capillary action (i.e., wicking) to the second port, thereby contacting and dissolving the first labelled antiligand along the way. If analyte is present in the sample, it will bind to an epitopic site on the labelled antiligand and pass therewith to the second membrane. The tightly fitted housing cover is adapted to retain all sample in the device, thus avoiding spillage and the need for any further contact between the sample and user.
The analyte sample fluid containing either labelled antiligand alone or a labelled antiligand/analyte complex (i.e., "first conjugate") will ascend by wicking up to the second membrane and along the latter to the patient test region beneath the first display bar. A first conjugate is present in the analyte sample fluid, the analyte therein will bind to an epitopic site on the immobilized second ligand, causing a reaction visible through the first display port.
For comparison, the analyte sample fluid will continue its migration along the second membrane past the first display port to the control bar beneath second display port. The labelled antiligand, conjugated or otherwise, will bind to the immobilized ligand present beneath in the control region, causing a visible reaction. If a reaction appears through the first display port which matches the reaction visible through the second, the test is positive for presence of analyte. If there is no reaction visible through the first port comparable in appearance to the control region, the test is negative for presence of analyte. If visible results appear through both display ports which are substantially dissimilar in appearance, the user is alerted that the test results are compromised and that the test should be repeated.
Several features of the inventive assay device assist in avoiding the latter set of test results. First, simultaneous migration of an excessive amount of analyte sample fluid is limited by requiring the fluid to ascend through the first membrane. If visible results appear through both display ports which are substantially dissimilar in appearance, the user is alerted that the test results are compromised and that the test should be repeated.
Second the impact of leading edge effects or depletion of bound antiligands or labels are minimized by physically separating the test and control regions and by using the presence of a reaction, rather than the appearance of a given shape, to signify a positive or negative result. Finally, the entire process is simplified by having the label reagent bound to a substrate placed within the device, thus avoiding any need to for the user to add a reagent or mix it with the analyte sample.
FIG. 1 is a perspective view of the assay unit;
FIG. 2 is an exploded view of the components of the assay unit;
FIG. 3 is an enlarged sectional view taken on line 3--3 of FIG. 1;
FIG. 4 is a sectional view taken on line 4--4 of FIG. 3; and
FIG. 5 is a sectional view taken on line 5--5 of FIG. 3.
FIG. 6 is a perspective view of the first and second membranes of the assay unit showing a positive assay result;
FIG. 7 is a perspective view of the first and second membranes of the assay unit showing a negative assay result;
FIG. 8 is a perspective view of the first and second membranes of the assay unit showing an inconclusive assay result.
1. Definitions
For ease of understanding, the following definitions will apply throughout this description:
a) Ligand
A molecule or compound having one or more epitopic sites; i.e., those points at which another molecule or compound will bind. Ligands for purposes of this invention may include luteinizing hormone or other naturally occurring biological ligands in serum, plasma, urine or other fluids, and will preferably include antigens.
b) Antiligand
Receptor molecules or compounds which bind to particular epitopic sites on ligands. Antiligands may in this context include any naturally occurring or prepared biological receptor, and will preferably include antibodies.
For simplicity, the terms antibody and antigen will be used throughout this disclosure. It will be appreciated by those skilled in the art, however, that the invention is not limited to use with antigens and antibodies.
c) Analyte Sample
A liquid suspected of containing ligands of interest for which a particular assay will be specific.
d) Label
A molecule or compound which directly or indirectly mediates the production of a signal (such as a color change) which is used in assay procedures to indicate the presence or absence of ligands of interest in an analyte sample. Labels may include enzymes, fluorecsors and will preferably include metal sols.
e) Metal Label
Labels of metal sols; i.e., metal or metal compounds such as metal oxides, metal hydroxides, metal salts or polymer nuclei coated with a metal or metal compound. These metal labels may include dry forms of any of the above-named metals or metal compounds, and will preferably include colloidal gold in dry form.
f) Conjugate
Depending on the context in which it is used, "conjugate" shall mean a analyte labelled antiligand molecule first produced in the assay ("first conjugate") or the analyte labelled antiligand/unlabelled antiligand molecule produced second in the assay method ("second conjugate").
2. Preferred Embodiments
Apparatus: The Assay Device
Turning to FIG. 1, there is shown a perspective view of an apparatus which can be used to perform assays in accord with the invention. FIG. 1 therefore depicts a housing 5 of rectangular shape (although any appropriate shape may be employed). Housing 5 is composed of two parts. The first is housing cover 10 in which three openings appear. The first opening is sample entry port 12, which preferably has sloping walls 13 defining a full or half funnel extending downwardly toward the bottom surface 22 of housing floor 20 (see, FIG. 2) As shown in FIG. 3 (a view taken along line 3--3 of FIG. 1, walls 13 will preferably stop short of touching bottom surface 22 by a distance sufficient for a porous membrane described to it between them.
The second and third opening through housing cover 10 each form a separate display port through which the test result can be viewed and compared to a control display. To this end, the first display port 15 and second display port 16 are preferably side by side for ease of comparison.
Turning to FIG. 2, the apparatus is shown in exploded view. In this view, it can be seen that housing floor 20 is divided into two distinct regions. The first is depression 25, which is defined by bottom surface 22, sidewalls 23 and slope 24. In a preferred embodiment (shown in FIG. 3), housing cover 5 will have a vertical bar 26 extending downwardly into depression 25 just in front of slope 24 to hold membrane 40 (described below) in place. The second region of housing floor 20 begins at the top of slope 24 and consists of an extended surface forming platform 30 parallel to and extending away from depression 25 as shown in FIG. 2, fluid gully 64 may be included as a sink for excess analyte sample. Platform 30 may extend the length of housing floor 20 from slope 24, or it may stop just short of the end of housing floor 20, leaving room for fluid gulley 32 to collect excess analyte sample fluid (in the same manner as fluid gulley 64 see, FIG. 5).
Contained within housing 5 will be first and second porous membranes 40 and 42. Preferably, an absorbent pad 43 for collection of excess analyte sample fluid will also be included. The preferred spatial relationship of these membranes are shown in FIG. 2 as follows:
First porous membrane 40 will be disposed within depression 25 and along slope 24 to platform 30. Preferably membrane 40 will be affixed to a nonporous substrate 41 such as coated paper by an adhesive or other suitable means. Substrate 41 will extend along platform 30 to form a surface to which second porous membrane 42 will be affixed. First porous membrane 40 and 42 will be in contact with, but need not be affixed, to the other. In the most preferred embodiment, membrane 40 will be split at its point of attachment to substrate 41 to extend above and below the substrate. This configuration serves to regulate the flow of analyte sample from membrane 40 to membrane 42. Flow control can also be enhanced by placement of a well 64 below the junction between membranes 40 and 42.
In a preferred embodiment of the device, locating points will be present in depression 25 and platform 30 (examples of these points are representatively shown in FIG. 2 as points 60 through 63). These locating points respectively identify where the ligands described below will be bound to membranes 40 and 42. When the membranes are properly aligned along the locating points, the bound ligands and antiligands will be placed beneath the various ports through housing cover 5 as follows:
At the point on first porous membrane 40 corresponding to locating points 60, a first soluble antiligand, preferably an antibody and most preferably an antibody to human chorionic gonadotropin (i.e., anti β-hCG) will be bound so as to be beneath sample entry port 12. The preferred material for the first porous membrane is a fiberglass product such as that which is marketed under the trade names "MANNIWEB" or "MANNIGLAS" by Lydall, Inc. Binding will be by use of soluble aminosilanes. Other suitable materials include polyethylene or nitrocellulose pads and strips; means for binding ligands to these materials are well-known in the art.
The first soluble antiligand will be labelled according to means known in the art. For purposes of producing a clearly visible reaction, labels of metal sols are preferred, with labels of colloidal gold or selenium being most preferred. An example of a suitable product is colloidal gold available from Janssen Life Sciences Products. These colloidal metals will produce colored reactions without addition of further reagents; however, flourescors (such as fluorescein and phycobiliprotein) and enzymes (such as those identified in U.S. Pat. No. 4,275,149, incorporated to that extent herein, may also be used. To maximize contact of analyte sample with labelled antiligand, the latter should be bound to the membrane across its face; i.e., from one side to the other (see, bar 65 shown in phantom on FIG. 2).
The second immovable antiligand will be bound to the second porous membrane in a position corresponding to locating point 61. This will be the location of the patient test region, which is aligned beneath display port 15 in the assembled test device. Second porous membrane 42 will preferably be a chromatographic strip coated with gelatin to enhance the life of the strip and clarity of any visible reactions produced in the test. The second antiligand may be immovably attached to membrane 42 by means known in the art, including covalent bonding or attachment to an insoluble protein-coated surface (see, e.g., U.S. Pat. No. 4,200,690, the disclosure of which is to that extent herein incorporated).
Preferably, the second immovable antiligand will be bound in a bar or oval shape extending from side to side of the membrane 42 in a manner similar to the attachment of the first soluble antiligand to membrane 40. Use of a simple, unidirectional configuration such as a bar avoids the need for the user to determine if a more complex shape (such as a "+" or a "-") has been sufficiently formed to indicate a particular result. Further, use of a simple shape overcomes the impact of leading edge effects by making test results dependent on the appearance through the appropriate port of any shape or color, rather than of the appearance of a particular shape or color.
At the region of second porous membrane 42 aligned to locating point 63 a ligand corresponding to the first soluble antiligand. Binding of the immobile ligand may be by the same methods described with respect to binding of the immobile second antiligand above. For ease of comparison, the shape and orientation of the immobile ligand membrane 42 should be similar to the shape and orientation of the immobile second antiligand.
Thus, when housing cover 5 is placed onto housing floor 20 (preferably by snapping [see, snaps 71 in FIG. 3 and 4] or other suitable coupling means to form snap-tight fit between the two [see, FIGS. 3 and 4]) the soluble first labelled antiligand will be bound beneath or near sample entry port 12, the immobile second unlabelled antiligand will be bound beneath first display port 15 and the immobile ligand will be bound beneath second display port 16.
3. Method: Ligand Assay Procedure
In applying the invention, an analyte sample such as urine which is suspected of containing human chorionic gonadotropin hCG ligand is applied by dropping or pouring (from a pipette or other container) the sample into sample entry port 12 of the assay device described above. No other steps will be taken by the user during the assay; i.e., no washing is required, no addition of a reagent is required and no movement of the device is necessary to obtain visual access to display ports 15 and 16. The user's only next contact with the assay device after the addition of the analyte sample will be to throw the device away when the assay is completed.
Ligands of interest in the analyte sample, if present, will bind by agglutination with the soluble first labelled antiligand on the first porous membrane 40 to form a first conjugate. If desired, further analyte sample may be added up to the maximum binding capacity of unlabelled antiligand and absorbency of the absorbent pad material 43 at the end of the assay. The first conjugates and unbound labelled antiligand, if any, will dissolve into the analyte sample and be carried along therewith by capillary action ("wicking") up to the second porous membrane 42. The position of the first antiligand and first conjugates, if any is indicated as 65 on FIGS. 2, 6 and 7.
All first conjugates carried with the analyte sample fluid will contact the second porous membrane 42. Sample will pass through that second porous membrane 42, bringing the first conjugates, if any, into contact with the second unlabelled antiligand immovably bound to the second porous membrane 70 to bind by agglutination therewith to form second conjugates of labelled antiligand-analyte-unlabelled antiligand. If second conjugates are formed, they will appear as display 66 (FIG. 6).
Analyte sample will continue its migration by wicking through second porous membrane 42 past the immobile second antiligand to the immobile ligand. Labelled first antiligand not conjugated to analyte will bind with the bound immobile ligand to form a third conjugate. The third conjugate will appear as display 67 (FIGS. 6 and 7). Formation of all conjugates in the assay method may be by sandwich or competitive immunoassay techniques well known to those skilled in the art. Within a predetermined time period, any second conjugate present and the third conjugate will undergo a visible color change mediated by the label. In a preferred embodiment, this color change will signal either a positive (analyte present) or negative (analyte not present) reaction by providing two separate reactive zones within those portions of second porous membrane 42 visible to the user through display ports 15 and 16.
For example, as shown in FIG. 6, a positive result is indicated when color changes forming substantially similar shapes (in this instance, horizontal bars 66 and 67) appear in both display ports 15 and 16. In contrast, as shown in FIG. 7, a negative result is indicated when a color change forming a distinguishable shape (e.g., a horizontal bar 67) appears only through display port 16. Finally, an inconclusive result is shown in FIG. 8, where color changes appear in both ports having substantially dissimilar shapes (i.e., horizontal bar 67 and smudge 68). In this latter instance, the user would be alerted that the test should be repeated. While due to the decreased impact of leading edge effects and similar phenomena in this assay it is not expected that inconclusive results will be frequent, the assay requires such a small application of analyte sample fluid that repetition should not be problematic in most applications.
Other control or comparative result signals may be provided, including signals which indicate whether an invalid result is obtained, by similar means known to those skilled in the art (see, e.g., the signal system described in European Patent Application No. 8611367.0 [Publication No. 0217 403 A2]).
The following example illustrates a preferred way of using the present invention when it is constructed to include the preferred structure and materials disclosed above. The example is, however, intended only to be illustrative and in no way should be construed to limit the scope of the invention as defined solely by the claims appended hereto. Specifically, it will be appreciated by those skilled in the art that the analyte of interest may be a protein, a peptide, an amino acid, a nucleic acid, a hormone, a steroid, a vitamin, a toxic or other chemical contaminant in the sample fluid, a pathogenic microorganism, and metabolites from analogs of, or antibodies to these substances.
This assay procedure is performed using beta-human chorionic gonadotropin (hereinafter "hCG") antibody to form the first conjugate and on anti-hCG-colloidal gold compound to form the second conjugate. The analyte sample is 1 cubic centimeter (hereinafter "cc") of urine suspected of containing HCG; the assay is performed at ambient temperatures not below or exceeding 15°-30° C.
The 1 cc of urine is added to sample entry port 12 by pipette. Within 3 minutes visible color changes (from pure white to pink) through substantially the center of display ports 15 and 16 on second porous membrane 42 are faintly visible. By the end of five minutes, a vividly pink bar symbol has appeared through substantially the center of each display port, indicating the presence of hCG in the sample. All other visible areas of the second porous membrane visible through the second port remain white (the normally visible color of the second porous membrane).
This assay may be performed within 7 days of a suspected conception.
Although the foregoing invention has been described in detail, it will be obvious to those skilled in the art that certain changes and modifications thereto may be made without departing from the scope or spirit of the invention.


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Anxiety Disorder is spreading rapidly now a day. In order to ensure survival, everyone has to deal with some amount of mental and physical stress. General anxiety or stress is a normal feeling and helps us to remain cautious and alert. However, some times the level of stress becomes so high that it becomes impossible for the affected person to handle it effectively. Or, the person becomes comparatively weak to handle even normal amount of stress. Astrology readings of Vedic horoscope can easily identify both the situations well in advance; and accordingly one can take advance precautions in this regard.
Primarily, it is the relationship among first house, eighth house, and the planets Moon and Saturn which may generate anxiety problems. The first house of your Vedic horoscope signifies your physique, nature and strength in general. If the lord of first house or Moon is weak and having relationships with eighth house; or eighth house lord is placed in first house; or Ascendant lord, Moon and Saturn are having a relationship either by conjunction or aspect in vedic horoscope of a person; it may have negative influence on the personality and the person concerned will become vulnerable to Anxiety Disorder. Under such circumstances, if the planets Moon and/or Saturn are weak- the chances of suffering from anxiety disorder will be grave.
The level of negative influence will depend upon the relationship of Moon and Saturn with first and eighth houses. Like, if Saturn becomes the lord of eighth house (Gemini or Cancer ascendant) and makes relationship with ascendant lord or Moon – the chances of anxiety disorder will be quite prominent and grave too. The strength of Ascendant lord, Moon and sixth and ninth houses will act as a protective cover. Like, the person may be able to deal with anxiety disorder through medication or other remedies; but he will surely be suffering from it to some extent. For balanced astrology readings in this regard, the Divisional charts should also be given due consideration. Operation of malefic planetary periods in the vedic horoscope will act as a trigger to generate significant negative influence. In nutshell, astrology readings of first and eighth houses, and the planets Moon and Saturn will indicate if the person may suffer from anxiety disorder or not; and the operating planetary period is the key to identity the timing of these inauspicious results taking place in the vedic horoscope. For better understanding, the astrology readings of following example horoscopes will be helpful.
This vedic horoscope belongs to famous American Celebrity -Allen Woody. The union of Saturn + Moon in seventh house of his Vedic Horoscope has caused Allen Woody to suffer from anxiety problems including many phobias. Ascendant lord Sun is united with eighth lord Jupiter and Mercury in fourth house of his vedic horoscope; and Saturn is also having its aspect over the union. As lord of sixth and twelfth houses respectively, Saturn and Moon are quite capable of influencing Allen Woody horoscope to generate health issue related with anxiety. The good placement of ascendant lord Sun and exalted Mars in sixth house helped Allen Woody to understand and deal with these inauspicious influences over his horoscope.
In this vedic horoscope, Saturn rules over fourth and fifth houses and is a Yogakaraka planet for Libra Ascendant. Saturn has gone to eighth house and the Moon is positioned in fifth house and also having aspect of badly placed Saturn. The ascendant lord Venus is united with Mars, which rules over second and seventh houses of the horoscope. As per vedic astrology readings, second and seventh houses are Maraka Bhavas; therefore, the union of Mars with Venus is not completely clean. The native was having hidden traits of anxiety issues right from adolescence; but were under control. However, during Saturn/Jupiter Bhukti, the inauspicious influence was significantly grave; and native suffered from many health issues including anxiety disorder. During antardasa of malefic sixth lord Jupiter, the badly placed Saturn, which is having relationship with Moon, did generated anxiety problems for the native despite being a Yogakaraka Planet for Libra Ascendant.
How Vedic Astrology Readings can help in Anxiety issues: Well, first of all – one may have advance information if there are any such inauspicious influences in his/her vedic horoscope or otherwise. Sometimes, even strong people fall prey to anxiety disorder and suffer. Having advance information in this regard may help the concerned person to remain alert in this regard and approach proper medical treatment even with minor indications. Quite often, people do not give due attention to minor symptoms of anxiety disorder; and it allows the problem to become grave. The use of suitable gemstones is another way of having some relief in anxiety disorder. Gemstones of planets, which are favorable and strong enough to act against the problem causing planets, can be expected to have good amount of control. Taking appropriate decisions in accordance with planetary placement is also helpful. Like, if indications of anxiety disorder are present in the vedic horoscope, one may take important decisions of his life in accordance.


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New York Jet Ski Adventure Tour
E-Voucher Delivery
Print or Email Instantly! You can also choose your send date.
When do I choose a date?
If giving as a gift, your recipient can choose a date at their convenience; otherwise, you can choose one after checkout.
Hassle-Free Policies
30 day returns. Free exchanges. No expiration dates.
1-Hour Tour:
May through October:
Daily - 8:30 AM AM to 5:00 PM
November through December:
Daily - 11:00 AM & 1:00 PM
2.5-Hour Tour:
May through October:
Daily - 7:00 AM to 5:00 PM
Whether a native or a tourist, you haven't seen New York City like this! Take in the sights from aboard a personal watercraft during this guided New York Jet Ski Adventure!
- Guided by an outstanding tour provider with a 5-star ranking on TripAdvisor
- Licensed instructors/guides will show you the city from a unique perspective
- Drive your own personal watercraft or ride as a passenger with up to 1 friend or loved one
- Choose between a 1-hour lower Manhattan tour or an extended 2.5-hour full island tour
- Visit such famous sites as Chelsea Piers, George Washington Bridge, Yankee Stadium, the Brooklyn Bridge and more!
Feel the rush of wind in your hair and the spray of the sea as you take in New York City in a whole new way!
You will meet your certified instructor and guide at the Liberty Landing Marina in Jersey City, a quick 10-minute ferry ride from lower Manhattan (ferry fare not included). Once there, you will be provided with a wet suit, life vest, and water shoes. You'll suit up and climb aboard your very own personal watercraft!
For this tour, you will be driving a Yamaha VP1 or VP1 Sport watercraft, commonly referred to as a jet ski. Though each jet ski can seat up to two participants, you may choose the option to drive alone or to bring along a passenger, provided your combined weight does not exceed 350 pounds. After a short safety briefing and basic training, you will head out onto the bustling New York City waterways to see the sights!
Along the way, your guide will take photos for you, provide interesting facts, and help you navigate the waterways. Want a bit of a thrill? You are free to test the limits of your jet ski, which can hit speeds of up to 55 MPH. Just make sure you are within eye sight of your guide.
For this adventure tour, you may choose between two routes:
- 1-Hour Lower Manhattan Tour: Explore the most famous sights in New York Harbor. Departing from the marina, you will cruise past Ellis Island, the Statue of Liberty, the Brooklyn Bridge, the Freedom Tower, and more! This will be an approximately 1-hour journey.
- 2.5-Hour Manhattan Tour: Get the full New York experience as you journey around the entire island of Manhattan. You will see the Freedom Tower, The Intrepid Aircraft Carrier & Sea Museum, 79th Street Boat Basin, the GW Bridge, Yankee Stadium, The United Nations, the Brooklyn Bridge, and so much more! This will be an approximately 2.5-hour adventure.
Essential Information
- Participants must be at least 18 years of age with a valid form of ID to drive a jet ski
- Non-driving passengers must be at least 16 years old with parental consent
- Combined weight of passengers on a dual jetski must not exceed 350 lbs
- All participants must wear a life vest
- Wet suits, water shoes, and life vests will be provided
DurationDepending on the option selected, this experience can be range from 1.5-3 hours.
Maximum ParticipantsUp to 2 passengers per jet ski, dependent on option selected and combined weight restrictions. Each tour is limited to 12 participants. For pricing beyond the options listed, please call Cloud 9 Living at 866-525-6839.
SpectatorsThis tour is for booked participants only.
Weather DependentThis experience is weather dependent. Always contact the experience provider with questions regarding weather conditions.
What To WearIt is recommended to wear a bathing suit or swim trunks. If you have your own water shoes or aqua socks, you may bring them but no other footwear is permitted on the watercraft. Water shoes, life vests, and wet suits will be provided.
Booking InformationFor this experience, it is recommended to request bookings at least 7 days in advance.
Cancellation PolicyPrior to scheduling/booking a date for this experience, Cloud 9 Living's standard return and exchange policy shall apply. Once you have scheduled a date and received a booking confirmation, cancellations and rescheduling are allowed up to 72 hours prior to the experience. Failure to appear on your booked date or cancel/reschedule 72 hours prior will result in the loss of the value of this experience.
Experience IDWAT-NEW-0055
Do I need experience driving a jet ski?
No! Jet skis are very easy to operate and your guide/instructor will spend a few minutes at the beginning of the tour to go over safety precautions and operation tips.
How many people can ride one jet ski?
1 or 2 people are allowed on each jet ski (depending on purchase option selected). However, each jet ski has a combined weight limit of 350 pounds.
If two people go on a jet ski, are we allowed to switch drivers?
Yes! Both participants are allowed to drive the jet ski provided they are both over 18 years old with valid form of ID. You may switch at any point during the tour.
What type of water craft will we use?
For this tour, you will be riding/driving a Yamaha V1's and V1 Sports. These personal water crafts (PWCs) are commonly referred to as Jet Skis.
Is there a better time of day to go on a tour?
Tour conditions vary greatly depending on the time of day due to the amount of boat traffic on the water. Mornings are generally the calmest conditions. Afternoon tours give you a true sense of how busy and bustling the NYC waterways can be and that provides its own thrill. Late afternoons are usually pretty magical in terms of scenery.
Is this experience weather dependent?
Yes. This experience can be subject to rain and wind conditions. Please always check with the experience provider prior to your tour with any concerns regarding weather.
- Do I need experience driving a jet ski?


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Welcome to
The Guild of Property Professionals
The Guild has created a series of guides to help you through the moving process
When it comes to moving home, you need professionals who are trained and trustworthy, with in-depth local knowledge and the technology and connections to market your property.
The Guild of Property Professionals is a network of 800 carefully selected Property Professionals, working together to deliver the best result for their customers. They are reputable, experienced agents who are audited to ensure they observe best practice. They have access to in-depth training, guaranteeing they know the industry and your local market inside-out. They also benefit from a wide range of marketing materials to ensure their properties are marketed properly, in the right places.
By choosing a Guild Member, you are in safe hand and will achieve a better result.
Being an independent agent puts you at an advantage – you are different, and we are proud to work alongside you.
There are a host of advantages to becoming a Member. Being part of The Guild means that you join a network which spans the UK, you are connected to like-minded businesses through shared values and dedication to the industry.
From detailed training via the Guild's Associate Scheme to the latest marketing tools to ensure your clients' properties stand out, The Guild is your partner when it comes to delivering best in class service.
Purchase price: £
Keep up-to-date with the latest property news or just enjoy some of our property related articles.


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The place was packed for lunch Wednesday — only hours after the "sneak preview" wound Tuesday night when 620 close friends waited to help Wolfgang Puck bow his latest — seventh — eatery in L.A., Red Seven, located in the red wing of the Pacific Design Center. Here's a tip for Graydon Carter — Red Seven could be the perfect place for Vanity Fair's Oscar party, no longer at the now-departing Morton's.
Red Seven is an airy eatery which ordinarily seats 225 but it opens into space atthe PDC to accommodate hundreds who attend the magazine's sought-after Oscar soiree. (Like I said, 620 were on hand for the eatery's own opening bash with the usual-elbow-to-elbow celebrants — a la Oscar partygoers).
Wolfgang, champagne glass in hand, glad-handed everyone as his platoons of servers provided non-stop drinks for all the exotic tasters — and sampling of the deliciously different menu to come. Unlike past restaurant successes, there's no open-to-view kitchen and waiters parade out from the behind-the-scenes with no end of samples of the full menu.
How to describe the new menu, Wolfie? "It's modern Trader Vic's," he accurately pegged it. The chef de cuisine is Yoshinori Kojima. The restaurant's designer is Martin Vahtra and Wolfgang puckishly admitted he'd gone overboard on the budget of Red Seven which boasts a lengthy welcoming bar for anticipated "happy hours" clientele in this neighborhood. After all, you get thirsty hiking through the miles of decorator suppliers in the Pacific Design Center. Currently, Puck's place is open only for lunch and "the happy hour." Dinner menu is still on the back burner.
Why the name Red Seven? "Seven" is Wolfie's lucky number. And on July 7, he and Gelila Assefa will marry on the Isle of Capri.


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Conversational feedback
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Automated notifications and clear guidance help everyone to complete the 360 without interrupting the daily workflow. As you can complete it on desktop and mobile (iPhone & Android), your employees can start the review process on one device and finish it on another.
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Ronald B. Herberman, M.D.
Arthur S. Levine, M.D.Download high resolution version
PITTSBURGH, September 19, 2001 — Clinical research has grown dramatically over the past decade as a result of an increase in knowledge, opportunities and funding. The University of Pittsburgh Schools of the Health Sciences has established a new Office of Clinical Research (OCR) to facilitate the process of clinical research, promote its value and foster communication among those involved in clinical research at the university.
"We have received wide-spread support for this office from program leaders throughout the Schools of the Health Sciences. By providing a broad infrastructure offering support to all clinical researchers, we cannot only more efficiently facilitate existing research and help our researchers, we can be more supportive to young investigators," said S. Clifford Schold, M.D., assistant vice chancellor for clinical research, Health Sciences, University of Pittsburgh. Dr. Schold, who reports to Ronald B. Herberman, M.D., associate vice chancellor for research, and to Arthur S. Levine, M.D., senior vice chancellor, Health Sciences, and dean of the School of Medicine, will have administrative responsibility for the office.
"The office is being established in response to the rapidly emerging and critical need of the faculty for a robust and sophisticated infrastructure in support of clinical trials," said Dr. Levine.
The OCR is organized into four operational units giving researchers specialized resources to help with planning and implementing clinical research. These units are:
Clinical Research Support Unit – This unit will guide the investigator and the research team through regulatory requirements, assist in subject identification and recruitment, and provide an independent safety monitoring committee for studies in progress.
Education Unit – This unit will assist with the coordination and development of educational programs in clinical research on the University of Pittsburgh campus, including the master's program in clinical research through the Clinical Research Training Program, educational programs organized through the Western Psychiatric Institute and Clinic (WPIC) and the University of Pittsburgh School of Nursing, and certification programs coordinated through the Research Conduct and Compliance Office (RCCO).
Informational Management Unit – This unit will coordinate information management services for clinical research across the Schools of the Health Sciences by facilitating communication between various database and information technology systems used by the schools. OCR will take on this responsibility in close collaboration with Charles Friedman, Ph.D., associate vice chancellor for biomedical informatics, University of Pittsburgh.
Sponsored Clinical Trials – This unit will establish relationships between the Schools of the Health Sciences and sponsors of clinical trials that include industrial sponsors, governmental sponsors and foundations and promote clinical trials and funding opportunities sponsored by federal agencies. The Sponsored Clinical Trials Unit will work closely with the Pittsburgh Clinical Research Network (PCRN), which primarily focuses on facilitating clinical trials sponsored by industry. Peter Small, executive director of PCRN, and Lisa Cohn, vice president for operations at PCRN, will play important roles in OCR.
"What we are doing with the OCR is providing a service that lets researchers bypass the complexities and nuances of the research process, putting the focus on their research – not the red-tape," said Laurel Yasko, R.N., B.S.N., C.C.R.C., director of the OCR.
Affiliated with the University of Pittsburgh Schools of the Health Sciences
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Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.
Pittsburgh, PA, USA | UPMC.com


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Italian Greyhound Rescue Florida rescues and adopts out Greyhounds across the entire state of Florida. You can also view Italian Greyhounds looking for homes at ItalianGreyhound.Rescueme.org and PetFinder.org.Continue Reading
Italian Greyhound Rescue Florida is part of the Italian Greyhound Club of America, which rescues Greyhounds in need across the United States. Non-profit organizations in different states are responsible for transporting, caring for and finding homes for the Greyhounds that the IGCA takes in. RescueMe.org is a search engine that allows users to browse adoptable animals across the country and filter searches by breed and location. PetFinder.org is similar to RescueMe.org, but animal shelters are not always registered to both sites, so the sites may show different results. Listings and availability are not always current, depending on how often a particular shelter updates its listings. A city or county animal shelter in any part of Florida can provide a list of breeds currently available for adoption, and these shelters can often provide information for more specialized rescues. Many of these groups are in desperate need of foster homes for animals. Foster "parents" of rescued dogs provide temporary homes and care for dogs until they can be placed in permanent homes. Adoption fees and applications differ between organizations.Learn more about Pets