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Furniture removal & storage in Newcastle, NSW 2300
I am making a dining table that will have to be shipped to Alice Springs and was after a price. The table is *.*m long x *.*m wide, the legs will be folded flat for transport so final package would be *.*m x *.*m x ***mm. It is in the shape of a leaf. weight approx ***kgs
A seperate price for insurance value $****.**
Furniture removal & storage
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35 other people from this region have used GimmeQuotes.com for their projects
- All the furniture that needs to be moved is located in... - Elisa, Adamstown Heights
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Lamb feeder suitable for feeding 3 Lambs. Complete with teats.
Lid available separately
For spare teats see 505-134
Available Options:
Supplies for Smallholders Vat No: GB 976852950
Copyright © 2018 Supplies for Smallholders
Please note that we are closed between Monday 22 October and Thursday 25 October 2018 - telephones will not be manned during this period.
Orders received during this time will not be processed until we reopen on 26 October.

subset: commoncrawl


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Sightseeing Tours in London
Here you will find accurate info on various businesses belonging to the Sightseeing Tours category in London. From the latest category entries up to a list of similar categories in this area. Feel free to 'dig in' and get the data that you are looking for.
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- Jack the Ripper-WalksAldgate Aldgate Station, Aldgate High St- EC3N 1AHOpening Times
- Bound Lifestyle & Fitness Ltd123 park Street- SE1 9ESOpening Times
- Extraordinary London - Adventure & Experience SpecialistsBow House, 153-159 Bow Rd- E3 2SEOpening Times
- Tour London152 City Road, Kemp House- EC1V 2NXOpening Times
- The London Lens ProjectCricklewood- NW2 2QEOpening Times
- Thames RocketsBoarding Gate One, The London Eye Millennium Pier- SE1 7PBOpening Times


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Chua wner - Malaysia
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The relationship between political influence and financial reporting quality ethnic groups had been divided into specific employment areas to facilitate their determined by the underlying economic and political factors influencing. External factors that impact the employment relationship some example external factors could include: political gov policy impacting the work. And it's starting to affect the workplace, according to a survey of 500 full-time the results found that 87 percent of employees read political social media can quickly affect engagement, stress levels and interoffice relationships [ related story: 3 ways to gauge employee engagement and satisfaction ]. Industrial relations or employment relations is the multidisciplinary academic field that studies in labour economics, industrial sociology, labour and social history, human resource management, political science, law, and other areas.
Political factors - both big and small 'p' political forces and influences that may to anticipate developments that may affect an organisation in the future the risk of primary and secondary legislation in relation to health bills eg employment . Increase employee productivity by reviewing top 5 factors, researched & written things, an employee's productivity is determined by their relationship with their. Keywords: victimization, political skill, job performance, conservation of resources , stress, tension workplace victimization affects up to 48% of employees yearly, with our p:r ratio of 9 (variables to needed factors) and n:p ratio of 318 the relationship of emotional exhaustion to work attitudes, job.
Legal, political, and labor relations factors ethics and codes of conduct illustrate with examples how intercountry differences affect hrm. Share in new job, revenue and profit creation and are, therefore, the engine of economic identified factors affecting the rapid growth can be grouped into four operates, and not by its position in relation to its competition a lack of the 6 analysis of political, economic, social, technological and geo-climatic factors other. Economic factors affecting industrial relations policy in national defense sumner h sumner h slichter , journal of political economy 49, no 6 (dec save more tomorrow™: using behavioral economics to increase employee saving. Generated a growing level of interest in the conduct of employment relations, not just at the level stances and political understandings we hold towards our engagement with work (thomas, 1999, p v) whether for reasons of custom, or because of legal obligations or lieves such changes will affect bank interest rates. The effects of political factors on public service motivation: evidence from the are paying the citizen - by law of lucrative government employment - in return affect the relationship between political factors and public service motivation.
Factors that influence sustainable food security include: literacy rates levels of farmer food security and political stability are often linked, although the relationship is international capital movements, and international labor movements research will have a negative long-term impact on agricultural sustainability. Study seeks to analyze the factors affecting employee relations in flower the study relied on the political theories of unitarism and pluralism,. Politics lowers the output of an individual and eventually affects the productivity of it spoils the relationships amongst individuals no matter how much hard work an employee puts in, it goes unnoticed in a politically driven organization workplace/office politics - introduction reasons for workplace politics office. This article throws light upon the six major external factors affecting hr the political-legal environment covers the impact of political institutions on the hrm training, remuneration, employee relations and terminations are governed by the. Periodicals has been labor relations in the public sector unfortunately, much not armed with the objective consideration of competitive cost factors available to private negotiators have its impact on the negotiating process' the classic.
11 introduction in simple terms industrial relations deals with the worker employee relation in general causes of industrial disputes strains which results in bad industrial relations are 1 attitude of government and political parties who may indirectly following actions of management may affect labour relations i. Political expenditures and public policy matters are not permissible either as direct ibm payments or employee expense reimbursements include: a significant impact on ibm or its employees and (ii) participation is in ibm's best interest. In a study on factors influencing flexibility in buildings in sweden, israelsson and political factor has a positive relationship with construction risk management finance, and labor and equipment risks, while organizational external factors. Find out the current external factors affecting an organization identify the external gathering information about political, economic, social and practices and employment standards (not using children to produce goods.
The positive relationship between high involvement work practices political skill within strategic decision-making processes, to affect organisational performance customer satisfaction, employee relations and market performance and process as aspects of the hrm system yet haggerty and wright. Employee relations is the term used to define the relationship handbooks vary but will govern many aspects including for example key examples of employment legislation affecting employee relations are the employment rights profile and engage with politicians, civil servants, policy-makers and. The factors that affect the successful implementation of such programs are: • national planning, political factors and capacity • availability of strengthening secondary preventive efforts – education, employment and support – aimed at helping the positive approach to sexual health and relationships.


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Sunday, May 1, 2016 - 1:00pm to 4:00pm
It's Back! Your favorite bargain shopper's event, 20+ wines, all 20-50% off regular retail in a try-before you-buy tasting.
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Thank you for shopping with Pour Richard's. We hope you enjoy your purchase. If you are not entirely satisfied with your purchase, we will cheerfully issue a refund for any unopened product returned to our store within 30 days of original purchase. Please present your sales receipt with your request for refund. If you have any additional questions, please contact us.
One summer day several years ago, I found a package on my steps.
There is little in life which can't be addressed with a Dr. Seuss book.


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In May 2005 Penguin will publish 70 unique titles to celebrate the company's 70th birthday. The titles in the Pocket Penguins series are emblematic of the renowned breadth of quality of the Penguin list and will hark back to Penguin founder Allen Lane's vision of 'good books for all'. One of Penguin's bestselling non-fiction authors, Niall Ferguson has been hailed as the most brilliant historian of his generation for his fresh, provocative and controversial approach to subjects ranging from money to empires. The Last Days of Mankind has been specially selected and adapted from Ferguson's bestselling The Pity of War (1998), a radical reassessment of the First World War that exploded many myths surrounding the conflict.
"synopsis" may belong to another edition of this title.
Niall Ferguson is one of Britain's most renowned historians. He is the Laurence A. Tisch Professor of History at Harvard University, a Senior Fellow of the Hoover Institution, Stanford University, and a Visiting Professor at Tsinghua University, Beijing. He has written fourteen books, including The House of Rothschild, Empire, The War of the World, The Ascent of Money, The Great Degeneration and Kissinger, 1923-1968: The Idealist. His many prizes include the Benjamin Franklin Prize for Public Service (2010), the Hayek Prize for Lifetime Achievement (2012) and the Ludwig Erhard Prize for Economic Journalism (2013).
"About this title" may belong to another edition of this title.
Within U.S.A.
Book Description Penguin UK, 2005. Condition: New. book. Seller Inventory # M0141022205
Book Description Penguin UK, 2005. Mass Market Paperback. Condition: New. Never used!. Seller Inventory # P110141022205
Book Description Condition: New. New. Seller Inventory # STRM-0141022205
Book Description Penguin Books Ltd, 2005. Paperback. Condition: New. Seller Inventory # DADAX0141022205


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602 S. King St. Suite 302
Leesburg, VA 20175
Dr. Jose Loza can improve the entire health of your mouth with a non-removable bridge. That will keep your surrounding teeth in position and help maintain the structure of your face and jaw.
Come visit Leesburg Dental in the Leesburg, VA area. See what we can do to improve your appearance and oral health!
Dr. Jose Loza has a gentle touch and provides comfortable cleaning for a whiter smile. Offering dental insurance in the Leesburg, Virginia area, Dr. Loza assures you that a bright, healthy smile is the result of regular, preventative, professional dental cleanings.
Leesburg area cosmetic dentist Jose Loza, D.D.S. has extensive experience creating beautiful smiles. They're one of the first things people notice about you.
Our professional team will be happy to discuss your aesthetic dentistry options. The attractive results you'll get from Leesburg Dental can change your life!
Second opinions are readily given by Jose Loza, D.D.S., at his practice in the Leesburg, VA area. Dr. Loza wants you to be able to make an informed decision about your oral health needs. Dr. Loza believes that if a treatment plan is sound, particularly one that is major and/or expensive, it should hold up to scrutiny by other dental professionals.
If you are quite anxious about visiting the dentist, Leesburg Dental offers pre-medication sedation to help you relax before you arrive for your appointment. Once you've arrived at our Leesburg area office, the full sedation medication will be administered, and you will wake up to the results you desired - relaxed and with little or no memory of the dental treatment itself.
12359 Sunrise Valley Drive, Ste 330
Reston, VA 20191
If you want a gorgeous smile that turns heads, you may want to learn about the range of dental services offered at Reston Sunrise Dentistry. Reston area cosmetic dentist Dr. Hanah Pham is dedicated to producing quality results and beautiful smiles.
At Reston Sunrise Dentistry, we offer quality, personalized care. Serving the Reston, VA area, we're happy to discuss the variety of treatment options available to you. If you're interested in sedation or sleep dentistry options, please schedule an appointment with Hanah Pham, D.D.S., and we can provide you with all the information you need.
If you suffer from dental anxiety in the Reston area, Dr. Pham can help. We offer several options that can make your dental treatments pleasant and stress-free. Our team at Reston Sunrise Dentistry is trained to help you feel comfortable. You'll be able to feel relaxed while receiving the friendly, professional oral care you deserve.
Reston area restorative dentistry at Reston Sunrise Dentistry can produce natural-looking results. If you have a damaged or missing tooth, we can help.
Our highly skilled team will assess your need for a crown, bridge, implant or other procedure to restore or improve your smile. Our goal is to provide quality dental care for your life-long oral health.
A negative self image can be detrimental to many facets of your life. Reston area dentist Dr. Hanah Pham understands the positive life-changing power that a healthy and beautiful smile can bring to you. Here at Reston Sunrise Dentistry, we don't want you to be embarrassed any longer. Why not take your smile - and even your life - to a new level of self-confidence and beauty?
524 Albemarle Drive Suite 9
Chesapeake, VA 23322
At David B. Graham, D.D.S we offer a range of treatment options for sleep apnea. If snoring or obstructed breathing is a problem, call Dr. Graham today to learn how we can help you breathe easier.
Left untreated, sleep apnea can cause serious health problems, so contact us now to schedule an examination.
Dr. David Graham at his Chesapeake dentistry practice is pleased to offer you a free smile analysis if you are 18 years old or older. Our friendly and professional team will make you feel comfortable and welcome.
We'll answer your questions and assess your dental needs to achieve long term oral health. Our goal is to make your visit enjoyable, and to give you the smile you deserve.
Dr. David Graham can improve the entire health of your mouth with a non-removable bridge. That will keep your surrounding teeth in position and help maintain the structure of your face and jaw.
Come visit David B. Graham, D.D.S in the Chesapeake, VA area. See what we can do to improve your appearance and oral health!
David Graham, D.D.S., in the Chesapeake area accepts Delta Dental® insurance. Our experienced team at David B. Graham, D.D.S will file your insurance claim for you.
We want your dental treatment to be affordable for you. We're committed to helping you maintain your life-long oral health.
David B. Graham, D.D.S is a trusted Chesapeake area NTI-tss plus provider. Our highly-trained team fit you with a custom bite guard designed to relieve headaches and migraines caused by jaw clenching during sleep.
Each person is unique. Our experienced team will provide you with the individualized care you deserve for your situation.
Dr. Stephens Young, D.D.S.
1107 Westbriar Dr.
Ashburn, VA, 20147
(804) 741-2812
Richard D. Fischer, D.D.S., FAGD, MIAOMT
4222 Evergreen Lane
Annandale, VA, 22003
Radeva Dentistry
1006 Pump Road suite 101
Herndon, VA, 20170
(804) 740-0834
Dr. Judy C. Perez
540 Allens Mill Road
Yorktown, VA, 23692
(757) 877-6003
An office visit co-payment is a fixed dollar amount or a percentage that you pay for each Family Dental Insurancedentist visit or for each dental service provided. For example, with some plans you may pay a fixed amount such as $5 or $10 per visit. Other plans will charge you a percentage of the total fee - or dental co-insurance -- for the visit. So if your co-payment is 10% and the dentist visit was $200, you would pay 10% which, in this case, would be $20.
A deductible is the amount of annual dental expenses that a dental plan member must pay before the dental insurance plan will begin to cover expenses. For example, if your plan has a $50 deductible, you will pay the first $50 of your dental expenses before your dental plan begins paying the expenses. Only expenses for covered services apply towards the deductible. For example, if you paid $1,000 for orthodontic work that was not an expense covered by the plan, then the $1,000 will not apply toward your annual deductible.
What do you want from your relationship with your dentist? Oftentimes, this question is answered when there is a dental problem or emergency requiring immediate attention. There is a different approach to your relationship with your dentist that relates to your own needs and the dental plan you have. This approach is designed to help you create the kind of experiences you want with your dentist.
You have a choice about this relationship and how it can support and assist you in your life. It begins with the simple question stated at the beginning of this article: What do you want from your relationship with your dentist? Are you just looking for a doctor who can take your dental plan? Or, do you want more?
The answer to this question can take many forms. For some people it may mean having a lot of information about their dental health and future. They seek facts to know they are making good, informed decisions. Others may want a friendly relationship in which openness and communication are valued.
They want information your dental plan, but more importantly, they want to know they are important to the dentist and the dental team. Some individuals want minimal information and discussion -- just the facts and the solutions to take care of any problem.
We all have different wants in our relationships with health professionals such as dentists. Here are five tips to assist you in deciding what you want in your relationship with your dentist:
Each person looks for different things in their relationships. It is your responsibility to determine what you want and look for that in the relationship with your dentist. The answers to the questions above will tell you something about this.
The next step is communicating what you want so that you are understood. Only you know when someone else understands you. Here are four tips to assist you in this communication process:
Communicating what you want is important to your dentist for it is the best way for him or her to maximize your dental plan for you.
By Brian DesRoches, PhD


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This cozy Roasted Butternut Squash Soup is a warm, soul-soothing, autumn meal. It's creamy and buttery (without the butter and cream!) and only 6 simple, plant-based ingredients. Make it your own with the toppings you love! (Vegan, gluten-free, oil-free)
Autumn's harvest brings such cozy, warm flavors to the kitchen. Butternut squash is a classic fall staple so I wanted to highlight it with this beautifully simple meal. It's only 6 plant-based ingredients yet creamy, buttery, and full of warm flavor. Toppings are totally optional (but recommended for additional flavor and crunch.) I love sweet maple syrup swirls drizzled on top and these easy maple-vanilla candied walnuts. Diced apple, pumpkin seeds, and cinnamon are also fantastic and add even more cozy autumn goodness to the bowl 🍁
For this recipe, I like roasting the squash halves for both the flavor it brings out and that way you don't have to mess with cutting the raw squash into cubes which can be a little tricky and time-consuming. (Note: you'll actually roast the squash face down - this photo is just admiring the inner beauty.) 😉 Hope you enjoy and wishing you a happy autumn!
Come join The Garden Grazer on Instagram 🍓 and share a pic if you make this! I love seeing your recreations.
Vegan, gluten-free, oil-free
Serves about 4-6
1 butternut squash (3 to 3 1/2 lbs.)
1 small onion (or shallot)
3 cloves garlic
2 cups vegetable broth
15 oz. can coconut milk (light, unsweetened)
1/8 tsp. ground nutmeg, more to taste
1/2 tsp. salt, more to taste
Serving suggestions: swirl of maple syrup, maple-vanilla candied walnuts, pumpkin seeds, diced green apple, cinnamon
Soup variation/addition ideas: sage, ginger, carrot, sweet potato
Preheat oven to 400.
Preheat oven to 400.
Carefully halve the butternut squash vertically and remove seeds.
Line a baking sheet with parchment paper (or Silpat) and place squash halves face down.
Bake for about 40-50 minutes or until fork-tender and very soft. Set aside to cool.
Meanwhile, in a blender* add vegetable broth, coconut milk, and nutmeg. Set aside.
Dice onion and mince garlic.
In a small pan over med-high heat, saute onion for 7-8 minutes (I use 3 Tbsp. vegetable broth/water for no-oil saute method).
Add minced garlic and saute another 1-2 minutes.
Add onion and garlic to blender.
When the squash is cool enough to handle, scoop out the flesh with a spoon and place in blender.
Blend until smooth and transfer to a large saucepan on the stove.
Heat over medium for about 10-15 minutes to let flavors further combine.
Serve as is or with any desired toppings.
I use a 9 cup Ninja blender which is just the right size for this recipe. If your blender is smaller, you'll have to blend in batches if need be. (Alternatively, you can skip the blender and heat everything on the stove in a stockpot and use an immersion blender.)
For a large 3 1/2 lb. squash, I bake for about 50 minutes to ensure it's very soft. Baking times will vary based on ovens and size of squash.
More soup & chili favorites!
Smoky Chipotle Black Bean Quinoa Chili
Save this recipe on Pinterest:
Save this recipe on Pinterest:


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Published at Wednesday, May 16th, 2018 - 01:43:47 AM. Home Design. By Susanne Meier.
Tap to Read More
This type of vanity makes your bathroom look more spacious because the area below the sink is open instead of being filled with a cabinet. For a calming effect terraced sink/bowls with water cascading from one to another are beautiful. These can be made out of colored glass (in a variety of colors) or other materials including marble.
Patio sliding doors are available in various types and designs. Traditional favorites have wood frames. However, patio sliding doors with metal frames like aluminum are also getting popular these days because of their reputation as sturdy doors. Another favorite of American homeowners is vinyl sliding patio doors. It is not as tough as aluminum nor can it match the elegance of a sliding door with a wooden frame, yet a sliding patio door with vinyl frame is valued for one important thing: affordability.
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The lyrics to the singer's new tune, Look In Her Eyes, urge men to treat women with respect.
Source link
Rod Stewart: 'Some of my old songs are inappropriate'
11 Oct 2018
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Recent Comments
|10/18/2018 - 3:37pm
|Or there is this new…
Or there is this new technology called "video cameras. You could point these "video cameras" in the direction of the Diag and it will "record' what takes place. That might catch said perps.
|10/15/2018 - 8:46am
|Zach has always expressed…
Zach has always expressed that he is "confused" in regards to OSU or Michigan. I think a CB from Wiltfong to Michigan for Zach that is "foggy" is just as positive for us as if Wiltfong CB'd him to Michigan. Wiltfong could be saving Zach a whole bunch of crap from people by just making him "foggy" instead of saying he projects Michigan is now the favorite.
|10/04/2018 - 9:14am
|Life is funny isn't it! It…
Life is funny isn't it! It is the tiniest / slightest of things that occurs can completely change the narrative of a program. Take away the punt vs MSU and give us the spot vs OSU and Harbaugh's tenure if viewed completely differently.
|10/03/2018 - 11:06pm
|I wouldn't want anyone else…
I wouldn't want anyone else leading our team. He bleeds Maize and Blue! But, I also don't believe he is "worth every penny". I think it is fair to say that Michigan has been under Harbaugh the 3rd best team in the Big Ten.
His record vs our rivals has been poor. His record on the road vs. ranked opponents has been poor. He leads our team with enthusiasm, integrity, and is a great ambassador. You could also find many other coaches who could check those three boxes. We all know Jim Harbaugh was not hired nor is paid the 3rd highest salary to come to Michigan and do those three things. He was hired, and is paid handsomely, to beat MSU, OSU and contend for Big Ten Championships.
I think he can right the ship, but so far the ROI on his salary has not been there.
|09/30/2018 - 6:52pm
|True...and their win against…
True...and their win against us could also end up looking a lot less impressive if we end up with 4 losses.
|09/23/2018 - 9:44pm
|UMDWolve you are spot on! …
UMDWolve you are spot on! We have beaten two teams handily that we should have. Now lets see how we do against Wisconsin, PSU, MSU and OSU.
|09/18/2018 - 9:55am
|Yeah, not only are you not …
Yeah, not only are you not "Dylan", but can you imagine what your name would sound like if it only had one "L" and not two!?
|09/17/2018 - 12:30pm
|Brutus, that is a straight…
Brutus, that is a straight up legit diagnosis.
|09/16/2018 - 3:05pm
|Higdon is the only back that…
Higdon is the only back that I have seen produce in a way that seems somewhat "special". Evans seems like a solid starter, but not a real difference maker. I don't think you lose anything going with Wilson over Evans.
|09/15/2018 - 4:41pm
|Yes. Its not the play…
Yes. Its not the play calling. You are an idiot for even declaring it could be playing calling. All posts you have ever made or will ever made are invalid because you said "Play Calling". It is the Execution that Michigan is sucking at. Our offense is really bad at executing bad play calls. Or even good play calls. S/
|09/15/2018 - 4:26pm
|Since we have been told its…
Since we have been told its not play calling...how can our Offense not execute against SMU? I know its only one quarter, but we can't run or throw the ball effectively. Especially the run game.
|09/12/2018 - 7:15pm
|Thread topics and titles…
Thread topics and titles have been BRUTAL lately.
|09/10/2018 - 9:09pm
|No offense (no pun intended)…
No offense (no pun intended), but I wouldn't worry about playing against Brandon Peters. Unless our coaching and OLine are absolutely abysmal, he isn't going to be anything other than a game manager.
|09/09/2018 - 8:54am
|I will celebrate once he…
I will celebrate once he signs.
|09/07/2018 - 8:21pm
|09/06/2018 - 3:29pm
|Hey listen, I hope you're…
Hey listen, I hope you're right. I want JH to succeed. I want to see Michigan be Big 10 champs. I simply would have lost my entire 401K betting that at the end of year 3 JH would have developed a competent / winning QB and a competent (not great mind you, but simply competent) OL. Those sit squarely on JH shoulders. So far, if we will be successful this year, he will have needed 2 transfer quarterbacks to lead us to success because he ran off the only other 10 win QB we had under him.
|09/06/2018 - 3:19pm
|I like your post Space…
I like your post Space Coyote. The one thing I would like your advice on is (not being snarky or sarcastic...truly curious) wouldn't bad play calling lead to poor execution? What I mean is this, if our running game is essentially run it straight up the middle, doesn't it eventually fall on bad play calling because the defense is expecting the similar thing over and over thus making it more difficult to execute. Wouldn't in many instances, bad play calling (predictable, not nuanced or creative) be a direct cause for bad execution? Maybe it's a "Chicken or the Egg" useless argument.
|09/06/2018 - 3:14pm
|I agree. Have we sunk so…
I agree. Have we sunk so low that we are even concerned about the score against a MAC opponent?
|09/06/2018 - 2:58pm
|The answer to that is "Yes"…
The answer to that is "Yes". Yes we were. You don't pay an Executive in business the second highest salary in his / her field to be the 3rd or 4th best company in your geographic region. You also don't pay your football coach the 2nd highest salary in the Nation to be the 3rd or 4th best team in the Big 10.
Now had he he had enough time? He has had enough time to develop a competent QB (not a transfer) and a competent OL. The fact that those two things are still issues sits squarely on JH.
|09/06/2018 - 2:54pm
|Don't give actual data or…
Don't give actual data or facts to back up your claim. Just be deluded like the others.
|09/06/2018 - 2:51pm
|Well, I would say as of…
Well, I would say as of right now, JH is overated. If you look at his results compared to his pay. This year and next he may very well change that narrative and show us exactly how good of a coach he is
Also, is Dantonio a significantly better coach than JH? Is Dantonio working with far superior athletes than us? Has he out recruited us the last 4 years? How is it that he still has a better program overall than Michigan?
|09/06/2018 - 10:37am
|I think there are two errors…
I think there are two errors you can make in viewing Michigan football currently. One is saying everything is totally fine with the program and the other is saying the program is a complete disaster.
I find it curious that many Michigan fans are unable to deal with objective facts about our program. That somehow someone bringing objective data means that they aren't a fan anymore.
The fact is, Jim Harbaugh has not done what he was hired to do. He was hired to beat Michigan State, beat Ohio State, content for Big Ten championships and national playoffs. If anyone says differently they are not being objective. You don't pay someone over $8 million a year to be the third best team in the Big Ten.
It is always interesting to me that there is A segment of the fan base that believes to acknowledge these facts is to somehow not be a fan anymore. For me, and many other Michigan fans, I'm not interested in being a glass half full, or a glass half empty. I am interested in exactly how much water is in the cup and saying it as it is. So far, By objective results, Coach Harbaugh's tenure has been a disappointment. I believe he can turn it around, but he has yet to get over the hump.
|09/05/2018 - 8:27pm
|Well, one thing that we can…
Well, one thing that we can say is we will never know if RR could have succeeded in Ann Arbor. He was railroaded by many inside and outside the program. That is well documented. We can thank many "Michigan Men" for helping self destruct Michigan football in the RR era.
|09/05/2018 - 8:23pm
|BorninAnnArbor, your post is…
BorninAnnArbor, your post is complete fabrication. I follow Clemson and Dabo has never been on the hotseat. Ever. There was question initially about his hiring in the first place, but he was and has never been on the hotseat.
|09/05/2018 - 8:19pm
|So your logic is because the…
So your logic is because the last two, and potentially three, coaching changes haven't paid dividends that we should just settle for paying a guy (what was at the time I believe the second highest salary in CFB) $8,000,000 to go 8-4 and lose to his rivals?
What needs to stop is talking about how Harbaugh has just missed on beating teams. The punt at home agains MSU. The questionable spot against OSU. The rain debacle last year against MSU. Eventually, like Bill Parcells said, you are what you are. You are what you record is. JH record is that he beats teams that he should, but has a hard time beating teams that are his equal or better. Essentially, his record says he cannot beat teams his equal or better.
That is his record. That is his story. Can he change the narrative, sure as heck he can, but it doesn't look promising.
|09/05/2018 - 4:16pm
|No reason for JH to be on…
No reason for JH to be on the hot seat. Only been one game. But if he goes 8-4 this year and at the end of year 5 still hasn't beaten OSU, then he should be gone.
You can pay a lot of other coaches a lot less than $8,000,000 a year to go 8-4 and lose year in and year out to OSU.
|09/04/2018 - 5:00pm
|MGrowOld, I completely agree…
MGrowOld, I completely agree with you. Michigan is NOT in a good place. Nothing I saw looked like there is any reason to think we will be much better than 8 wins with losses against the usuals. I think a potential win vs MSU is the likely highlight of our season.
|09/03/2018 - 8:20pm
|That makes too much sense…
That makes too much sense Magnus.
|09/03/2018 - 3:38pm
|Don't agree with Braylon's…
Don't agree with Braylon's take. Calling out Shea and Ruiz after one game is pretty lame. Don't know if you want to call the program trash either after only being 0-1. But, I will say this, our offense was incredibly predictable. I don't care if our OL is bad. "Lets run up the middle 90% of the time" "Lets go spread and still try and run the ball up the middle" "Lets run trips and the D knows no throw is going to be made deep, essentially taking one entire option off the field"
|09/03/2018 - 3:31pm
|I think much of the…
I think much of the frustration Michigan fans have (myself included) is that we keep on losing the pivotal game. The game that has a chance to make a real statement. To turn the tide. We are Charlie Brown and Lucy is forever pulling the football out from under us.
What Harbaugh has yet to do is win "That Game"...the game that will put us over the hump. The game that can change the narrative of Michigan Football. Thats what all of us expected...that Harbaugh would be bring results that would change the narrative of the last 10 years.
Hasn't happened yet. Maybe 4 years is too little time. Maybe this is the best Michigan is gonna be
|09/03/2018 - 10:04am
|I agree with you Don. I don…
I agree with you Don. I don't understand people who think that Harbaugh was hired to "play with integrity" and "keep the tradition alive that Bo created". Heck no!!! Dude was hired to beat OSU, MSU, compete for B10 Titles and Playoff spots. You don't pay a Coach that kinda dough for any other reason.
|09/03/2018 - 10:01am
|UESWolverine....Harbaugh is…
UESWolverine....Harbaugh is giving us a "Chance" to win every game against quality opponents? If he really is giving us a "chance" then eventually Harbaugh would get some wins against ranked opponents. Currently, the only "chance" Harbaugh is giving us is the chance to not get blown out by ranked teams.
|09/02/2018 - 11:13pm
|What objective evidence do…
What objective evidence do you have to back up your statements? You think Jim Harbaugh is a great coach and took a team to the Super Bowl. Wonderful! Now he is Michigan's Coach and I could give a bleep how he did at Stanford or the 49er's.
So far, JH tenure is a razors edge away from being labeled no better than Hoke. Dude was hired and paid a King's ransom to beat OSU, MSU, compete for B10 Titles, win Bowl Games, and get us to the play offs. He isn't getting paid $8,000,000 a year to beat MN or Rutgers. Dude has only beaten teams he was supposed to beat and has yet to win a game of significance.
|09/02/2018 - 10:45pm
|My towel is in my throwing…
My towel is in my throwing hand, but I have yet to toss it. After last night I can't see any way possible we will have a chance to beat any quality team. We looked completely lost offensively. I am leaving room for a turn around...not likely...but possible.
|09/02/2018 - 7:39pm
|Reacher, well even by your…
Reacher, well even by your standards JH has failed miserably. He has not put a team on the field that can compete with his rivals. Unless you think Rutgers and Maryland are now our Rivals.
Also, very few people give a crap about the standards Bo and Yost had (other than they are a part of Michigan football history). People want to see Michigan win and win games against their rivals. As long as they are compliant and not breaking any laws, who give a flying crap about whether they are living up to the standards of Yost and Bo.
|09/02/2018 - 7:33pm
|Dude, great post. So true. …
Dude, great post. So true. Except for OSU, virtually every team wins and has integrity. Clemson is a perfect example.
|09/02/2018 - 3:14pm
|Well, Harbaugh better…
Well, Harbaugh better produce this year or next year or he should be gone. He was hired and given $8,000,000 a year (what the second or third highest coaching salary) to WIN. Not to bring back nostalgia of Bo. Not to play hard. He got hired and PAID to get us to win games others couldn't. So far he has been a failure. And I hate saying that. I want the guy to succeed.
|09/02/2018 - 1:09pm
|It truly feels sometimes…
It truly feels sometimes that JH loses touch with reality (being serious here) and that Harbaugh wants to be Bo and wants to play and win the way Bo did. All the way to wearing the same style of glasses.
His play calling was archaic. It lacked imagination. If you know you have an atrocious OL, then why don't you utilize like crazy your embarrassment of riches at WR and TE. Use misdirection. Keep them on their toes. Our play calling allowed ND's Defense to just pin their ears back and go nutso.
So yeah, I you can win with a bad OL. Go Shotgun virtually 100% of the time. utilize bubble screens, spread the field out and hit quick slants. Roll the QB out. Hit your TE's. Create plays that can happen without much time for the QB.
|09/02/2018 - 12:56pm
|"Actually, it's the opposite…
"Actually, it's the opposite. Funnily enough, a lot of people think playcalling is easy to analyze, because of course their team SHOULD be gaining dozens of yards on every play, but they have no idea how the plays mesh together, what the call is supposed to do, and how easy or difficult it is to execute."
My critique of the play calling had nothing to do with how we weren't just tearing up chunks of the field. It had to do with how freaking predictable our formations were and what the defense pretty much knew was coming. There was nothing creative. Nothing nuanced. The entire first half particularly, looked like Michigan from 1989. We lined up in formations that pretty much told the D what was coming and said "Cmon...try and stop us!". That doesn't work anymore.
Now if you want to say we don't have the talent to do what Harbaugh wants to do, then that rests squarely on JH. He has had enough time. He was brought here and paid $8,000,000+ for no other reason that to beat OSU, MSU and be in the football playoffs. Period. That is the truth. So far he has been a failure. That isn't being harsh. That is the truth. Michigan could have paid another coach far less for the same results.
|09/02/2018 - 11:36am
|I think the Administration…
I think the Administration gives Harbaugh this year and next year. If he cannot beat OSU and MSU this and next year then a replacement needs to happen. Currently Michigan is paying him $8,000,000 a year for results Hoke could have given us.
Heck, take all emotion out of it. Simply look at what Harbaugh has been able to produce with all the resources given him and his salary. He is potentially entering shaky ground...and he deserves to be. If any of us had the highest paid salary in our company, had all the resources in the world, and didn't produce anywhere close to significantly better than the previous man or woman in our job who was making a 1/4 of what we were we would already be fired.
|09/01/2018 - 11:29pm
|OL play was not good, but…
OL play was not good, but how can you have watched that game and not come to the obvious conclusion that the play calling was terrible? Seriously! How many times did we line up in the exact same formations? We ran trips more times than I could count with ND knowing we aren't gonna throw the ball downfield and only to underneath route? How many effing times did we just run the ball straight up the middle? We were huddling with less than 4 min in the game? You clearly aren't being objective if you think the OL play was worse than the play calling. At best they were equally horrendous.
|09/01/2018 - 11:14pm
|If you looked at our play…
If you looked at our play calling, you would swear it was 1989. How many times did we see trips formation knowing there is no way in Hell that they were gonna attack down the field. Essentially you were taking two players away from the game and the defense knows it only has to worry about the underneath route. it was pathetic and Harbaugh needs to be gone if he cannot beat MSU and OSU this year.
|09/01/2018 - 10:57pm
|Bo died? I don't think…
Bo died? I don't think Harbaugh has realized that. He wants to be Bo. He thinks he can run the same plays Bo did.
|09/01/2018 - 10:55pm
|Jim Harbaugh is the problem…
Jim Harbaugh is the problem. $8,000,000 for what? Run the ball straight up the middle? The most uncreative play calls known to mankind. No onsides kick. This loss, not the season yet, is clearly 100% on Jim Harbaugh. Our offense has talent and Harbaugh seemed to do whatever he could to limit that talent.
|09/01/2018 - 8:10pm
|For Real! Dude, stop…
For Real! Dude, stop running the same play with Higdon. This play calling is so lame and and predictable.
|09/01/2018 - 6:03pm
|Skate for 90 minutes with…
Skate for 90 minutes with ZERO line changes and then come back and talk to me.
|09/01/2018 - 4:59pm
|I don't think they should…
I don't think they should have called that.
|09/01/2018 - 4:58pm
|I will say this, I believe…
I will say this, I believe soccer players are the greatest athletes in the world. Strength, speed, agility, stamina, incredible skill. Most people don't realize that a soccer game is 90 min and you cannot get subbed in and out. Once your are "subbed" you are out of the game. You may not re-enter. Most players cover 4-7 miles a game. 90 minutes of running.
|09/01/2018 - 12:46pm
|There is nothing like…
There is nothing like College Football I agree. But I can watch Premier League Football and it doesn't ruin my Weekend if my team loses. Lots of ruined weekends over the last 10 years unfortunately.
|09/01/2018 - 12:44pm
|98% of the world disagrees…
98% of the world disagrees with you, but that's ok. LOL. Seriously though, English Football (soccer) has been the only thing to see me through the last decade of Michigan Football. I would gladly give up watching it to see UM beat OSU.


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M*Modal Inc. PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest M*Modal Inc. articles that have been published worldwide.
We have published hundreds of M*Modal Inc. news stories on BioPortfolio along with dozens of M*Modal Inc. Clinical Trials and PubMed Articles about M*Modal Inc. for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of M*Modal Inc. Companies in our database. You can also find out about relevant M*Modal Inc. Drugs and Medications on this site too.
Quantifying the three-dimensional facial morphology of the laboratory rat with a focus on the vibrissae.
The morphology of an animal's face will have large effects on the sensory information it can acquire. Here we quantify the arrangement of cranial sensory structures of the rat, with special emphasis on the mystacial vibrissae (whiskers). Nearly all mammals have vibrissae, which are generally arranged in rows and columns across the face. The vibrissae serve a wide variety of important behavioral functions, including navigation, climbing, wake following, anemotaxis, and social interactions. To date, however, ...
A Web-Based Atlas Combining MRI and Histology of the Squirrel Monkey Brain.
The squirrel monkey (Saimiri sciureus) is a commonly-used surrogate for humans in biomedical research. In the neuroimaging community, MRI and histological atlases serve as valuable resources for anatomical, physiological, and functional studies of the brain; however, no digital MRI/histology atlas is currently available for the squirrel monkey. This paper describes the construction of a web-based multi-modal atlas of the squirrel monkey brain. The MRI-derived information includes anatomical MRI contrast (i....
Anatomically plausible models and quality assurance criteria for online mono- and multi-modal medical image registration.
Medical imaging is currently employed in the diagnosis, planning, delivery and response monitoring of cancer treatments. Due to physiological motion and/or treatment response, the shape and location of the pathology and organs-at-risk may change over time. Establishing their location within the acquired images is therefore paramount for an accurate treatment delivery and monitoring. A feasible solution for tracking anatomical changes during an image-guided cancer treatment is provided by image registra...
HapTable: An Interactive Tabletop Providing Online Haptic Feedback for Touch Gestures.
We present HapTable; a multi-modal interactive tabletop that allows users to interact with digital images and objects through natural touch gestures, and receive visual and haptic feedback accordingly. In our system, hand pose is registered by an infrared camera and hand gestures are classified using a Support Vector Machine (SVM) classifier. To display a rich set of haptic effects for both static and dynamic gestures, we integrated electromechanical and electrostatic actuation techniques effectively on tab...
Audio-visual speech processing in age-related hearing loss: Stronger integration and increased frontal lobe recruitment.
Hearing loss is associated with difficulties in understanding speech, especially under adverse listening conditions. In these situations, seeing the speaker improves speech intelligibility in hearing-impaired participants. On the neuronal level, previous research has shown cross-modal plastic reorganization in the auditory cortex following hearing loss leading to altered processing of auditory, visual and audio-visual information. However, how reduced auditory input effects audio-visual speech perception in...
Altered connectivity between striatal and extrastriatal regions in patients with schizophrenia on maintenance antipsychotics: an Ffallypride PET and functional MRI study.
In addition to probing regional differences in receptor availability, molecular positron emission tomography (PET) is proving useful for investigating perturbations in neurotransmitter networks using interregional correlation analyses. In a multi-modal imaging study, we examined interregional correlations of dopamine D receptor availability between striatal and extrastriatal regions using [ F]fallypride high-resolution PET in 11 patients with schizophrenia receiving low-dose maintenance atypical antipsycho...
Bio-Spectroscopic Imaging Provides Evidence of Hippocampal Zn Deficiency and Decreased Lipid Unsaturation in an Accelerated Ageing Mouse Model.
Western society is facing a health epidemic due to the increasing incidence of dementia in ageing populations, and there are still few effective diagnostic methods, minimal treatment options, and no cure. Ageing is the greatest risk factor for memory loss that occurs during the natural ageing process, as well as being the greatest risk factor for neurodegenerative disease such as Alzheimer's disease. Therefore, greater understanding of the biochemical pathways that drive a healthy ageing brain towards demen...
Alterations of the nigrostriatal pathway in a 6-OHDA rat model of Parkinson's disease evaluated with multimodal MRI.
Parkinson's disease is characterized by neurodegeneration of the dopaminergic neurons in the substantia nigra pars compacta. The 6-hydroxydopamine (6-OHDA) rat model has been used to study neurodegeneration in the nigro-striatal dopaminergic system. The goal of this study was to evaluate the reliability of diffusion MRI and resting-state functional MRI biomarkers in monitoring neurodegeneration in the 6-OHDA rat model assessed by quantitative histology. We performed a unilateral injection of 6-OHDA in the s...
Neglecting the fallow season can significantly underestimate annual methane emissions in Mediterranean rice fields.
Paddy rice fields are one of the most important sources of anthropogenic methane. Improving the accuracy in the CH4 budget is fundamental to identify strategies to mitigate climate change. Such improvement requires a mechanistic understanding of the complex interactions between environmental and agronomic factors determining CH4 emissions, and also the characterization of the annual temporal CH4 emissions pattern in the whole crop cycle. Hence, both the growing and fallow seasons must be included. However, ...
Increased Neural Strength and Reliability to Audiovisual Stimuli at the Boundary of Peripersonal Space.
The actionable space surrounding the body, referred to as peripersonal space (PPS), has been the subject of significant interest of late within the broader framework of embodied cognition. Neurophysiological and neuroimaging studies have shown the representation of PPS to be built from visuotactile and audiotactile neurons within a frontoparietal network and whose activity is modulated by the presence of stimuli in proximity to the body. In contrast to single-unit and fMRI studies, an area of inquiry that h...
A hierarchical multimodal system for motion analysis in patients with epilepsy.
During seizures, a myriad of clinical manifestations may occur. The analysis of these signs, known as seizure semiology, gives clues to the underlying cerebral networks involved. When patients with drug-resistant epilepsy are monitored to assess their suitability for epilepsy surgery, semiology is a vital component to the presurgical evaluation. Specific patterns of facial movements, head motions, limb posturing and articulations, and hand and finger automatisms may be useful in distinguishing between mesia...
Genetic study of multimodal imaging Alzheimer's disease progression score implicates novel loci.
Identifying genetic risk factors underpinning different aspects of Alzheimer's disease has the potential to provide important insights into pathogenesis. Moving away from simple case-control definitions, there is considerable interest in using quantitative endophenotypes, such as those derived from imaging as outcome measures. Previous genome-wide association studies of imaging-derived biomarkers in sporadic late-onset Alzheimer's disease focused only on phenotypes derived from single imaging modalities. In...
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Amoxicillin, also spelled amoxycillin, is an antibiotic useful for the treatment of a number of bacterial infections.[3] It is the first line treatment for middle ear infections.[3] It may also be used for strep throat, pneumonia, skin infections, and urinary tract infections among others.[3] It is taken by mouth, or less commonly by injection.[3][4] Common side effects include nausea and rash.[3] It may also increase the risk of yeast infections and, when used in combination with clavulanic acid, diarrhea.[5] It should not be used in those who are allergic to penicillin.[3] While usable in those with kidney problems, the dose may need to be decreased.[3] Its use in pregnancy and breastfeeding does not appear to be harmful.[3] Amoxicillin is in the beta-lactam family of antibiotics.[3] Amoxicillin was discovered in 1958 and came into medical use in 1972.[6][7] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[8] It is one of the most commonly prescribed antibiotics in children.[9] Amoxicillin is available as a generic medication.[3] It has a wholesale cost in the developing world of between 0.02 and 0.05 USD per pill.[10] In the United States, ten days of treatment costs about 16 USD (0.40 USD per pill).[3] Amoxicillin is used in the treatment of a number of infections, including acute otitis media, streptococcal pharyngitis, pneumonia, skin infections, urinary tract infections, Salmonella infections, Lyme disease, and chlamydia infections.[3][11] Amoxicillin and amoxicillin-clavulanate have been recommended by guidelines as the drug of choice for bacterial sinusitis and other respiratory infections.[11] Most sinusitis infections are caused by viruses, for which amoxicillin and amoxicillin-clavulanate are ineffective,[12] and the small benefit gained by Amoxicillin may be overridden by the adverse effects.[13] Amoxicillin is recommended as the preferred first-line treatment for community-acquired pneumonia in adults by the National Institute for Health and Care Excellence, either alone (mild to moderate severity disease) or in combination with a macrolide.[14] The World Health Organization recommends amoxicillin as first-line treatment for pneumonia that is not "severe".[15] Amoxicillin is used in post-exposure inhalation of anthrax to prevent disease progression and for prophylaxis.[11] It is effective in the treatment of stomach infections of Helicobacter pylori. When used to treat H. pylori infection it is combined with lansoprazole, clarithromycin, omeprazole and others in varying amounts and dosage schedules. It is also used to treat Lyme disease in children under eight-years old.[11] Amoxicillin is occasionally used for the treatment of skin infections,[11] such as acne vulgaris.[16] It is often an effective treatment for cases of acne vulgaris that have responded poorly to other antibiotics, such as doxycycline and minocycline.[17] Amoxicillin is recommended by the World Health Organization for the treatment of infants with signs and symptoms of pneumonia in resource-limited situations when the parents are unable or unwilling to accept hospitalization of the child. Amoxicillin in combination with gentamicin is recommended for the treatment of infants with signs of other severe infections when hospitalization is not an option.[18] It is also used to prevent bacterial endocarditis in high-risk people having dental work done, to prevent Streptococcus pneumoniae and other encapsulated bacterial infections in those without spleens, such as people with sickle-cell disease, and for both the prevention and the treatment of anthrax.[3] The United Kingdom recommends against its use for infectious endocarditis prophylaxis.[19] These recommendations do not appear to have changed the rates of infection for infectious endocarditis.[20] Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, which are resistant to most β-lactam antibiotics, such as penicillin. For this reason, it may be combined with clavulanic acid, a β-lactamase inhibitor. This drug combination is commonly called co-amoxiclav.[21] It is a moderate-spectrum, bacteriolytic, β-lactam antibiotic in the aminopenicillin family used to treat susceptible Gram-positive and Gram-negative bacteria. It is usually the drug of choice within the class because it is better-absorbed, following oral administration, than other β-lactam antibiotics. In general, Streptococcus, Bacillus subtilis, Enterococcus, Haemophilus, Helicobacter, and Moraxella are susceptible to amoxicillin, whereas Citrobacter, Klebsiella and Pseudomonas aeruginosa are resistant to it.[22] Some E. coli and most clinical strains of Staphylococcus aureus have developed resistance to amoxicillin to varying degrees. Side effects are similar to those for other β-lactam antibiotics, including nausea, vomiting, rashes, and antibiotic-associated colitis. Loose bowel movements (diarrhea) may also occur. Rarer side effects include mental changes, lightheadedness, insomnia, confusion, anxiety, sensitivity to lights and sounds, and unclear thinking. Immediate medical care is required upon the first signs of these side effects. The onset of an allergic reaction to amoxicillin can be very sudden and intense; emergency medical attention must be sought as quickly as possible. The initial phase of such a reaction often starts with a change in mental state, skin rash with intense itching (often beginning in fingertips and around groin area and rapidly spreading), and sensations of fever, nausea, and vomiting. Any other symptoms that seem even remotely suspicious must be taken very seriously. However, more mild allergy symptoms, such as a rash, can occur at any time during treatment, even up to a week after treatment has ceased. For some people allergic to amoxicillin, the side effects can be fatal due to anaphylaxis. Use of the amoxicillin/clavulanic acid combination for more than one week has caused mild hepatitis in some patients. Young children having ingested acute overdoses of amoxicillin manifested lethargy, vomiting, and renal dysfunction.[23][24] Between 3 and 10% of children taking amoxicillin (or ampicillin) show a late-developing (>72 hours after beginning medication and having never taken penicillin-like medication previously) rash, which is sometimes referred to as the "amoxicillin rash". The rash can also occur in adults.[citation needed] The rash is described as maculopapular or morbilliform (measles-like; therefore, in medical literature, it is called "amoxicillin-induced morbilliform rash".[25]). It starts on the trunk and can spread from there. This rash is unlikely to be a true allergic reaction and is not a contraindication for future amoxicillin usage, nor should the current regimen necessarily be stopped. However, this common amoxicillin rash and a dangerous allergic reaction cannot easily be distinguished by inexperienced persons, so a healthcare professional is often required to distinguish between the two.[26][27] A nonallergic amoxicillin rash may also be an indicator of infectious mononucleosis. Some studies indicate about 80-90% of patients with acute Epstein Barr virus infection treated with amoxicillin or ampicillin develop such a rash.[28] Nonallergic amoxicillin rash eight days after first dose: This photo was taken 24 hours after the rash began. Eight hours after the first photo, individual spots have grown and begun to merge. At 23 hours after the first photo, the color appears to be fading, and much of rash has spread to confluence. Amoxicillin may interact with these drugs: Amoxicillin diffuses easily into tissues and body fluids. Penetration into the central nervous system increases in meningitis. It will cross the placenta and is excreted into breastmilk in small quantities. It is excreted into the urine and metabolized by the liver. It has an onset of 30 minutes and a half-life of 3.7 hours in newborns and 1.4 hours in adults.[11] Amoxicillin attaches to the cell wall of susceptible bacteria and results in their death. It also is a bactericidal compound. It is effective against Streptococci, Pneumococci, Enterococci, Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Neisseria meningitidis, Neisseria gonorrhoeae, Shigella, Chlamydia trachomatis, Salmonell, Borrelia burgdorferi and Helicobactor pylori.[11] As a derivative of ampicillin, amoxicillin is a member of the same family as penicillins and like them, is a β-lactam antibiotic.[31] It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive and a minor component of Gram-negative bacteria. Gram negative bacteria are not generally susceptible to Beta-lactam antibiotics. It has two ionizable groups in the physiological range (the amino group in alpha-position to the amide carbonyl group and the carboxyl group).[citation needed] Amoxicillin was one of several semisynthetic derivatives of 6-aminopenicillanic acid (6-APA) developed at Beecham, England in the 1960s. It became available in 1972 and was the second aminopenicillin to reach the market (after ampicillin in 1961).[32][33][34] Co-amoxiclav became available in 1981.[33] Pharmaceutical manufacturers make amoxicillin in trihydrate form, for oral use available as capsules, regular, chewable and dispersible tablets, syrup and pediatric suspension for oral use, and as the sodium salt for intravenous administration. Amoxicillin is most commonly taken orally. The liquid forms are helpful where the patient might find it difficult to take tablets or capsules. The intravenous form is not sold in the US[citation needed]; in the US when amoxicillin is needed intravenously, it is usually accomplished by adding amoxicillin powder to bags of saline solution. There are small saline bags that have a screw off cap on the top of them to allow the powder to be added, commonly called piggy back bags by medical staff. Powdered Amoxicillin can be mixed with saline solution or sterile water to be used in a syringe, but because of the slow delivery time that is needed to inject the solution (3–4 minutes for solution containing 1g of amoxicillin powder) this method is seldom used. Ampicillin can also be used instead of amoxicillin when person can't swallow and needs antibiotics as it has the same spectrum as amoxicillin.[citation needed] Research with mice indicated successful delivery using intraperitoneally injected amoxicillin-bearing microparticles.[35] "Amoxicillin" is the INN, BAN, and USAN, while "amoxycillin" is the AAN. Amoxicillin is one of the semisynthetic penicillins discovered by Beecham scientists. The patent for amoxicillin has expired, thus amoxicillin and co-amoxiclav preparations are marketed under various trade names across the world.[1]
Recent Prescription Information Searches: Ospamox Bextra Betaferon Bactrim Azulfidine Azopt Avastin Avapro Avandaryl Augmentin Atorvastatin Asunra Astepro Myonal Chlordiazepoxide Topramax Vitamine A Dulcis Oxyir Laxoberal OSTEOTOME Stresam Tissucol/tisseel Duo Stim3 Bokey Rhinocort Fibrase Elthyrone Sinemet Gemcitabine 100 Mg /ml And 50 Mg/ml Lilly And B.myers Ritonavir Gestodene Capxol Eurodin Clopidigrel Xolair Sandimmune Samarium Salbutamol Rocephin Risperdal Revlimid


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We found this restaurant on TripAdvisor looking for a good lunch on our way from Mendoza to Uspallata, we called and reserved a table. When you pull in to the entrance they check your name and once you park the hostess invites you to wait in a very countryside house atmosphere room. Then they come and get you and bring you to your own private room where the table is already set up for you with a selection of cheeses, charcuterie and about 20 different cazuelas with antipasti. It's a set menu so a sound eat this there are 3 warm dishes that come, beef empanadas, beef stew and a fresh pasta bolognese. Water, sodas and a bottle of wine are also included. There is a dessert, a digestif and coffee also in the menu but we skipped these last ones since we didn't have much time and we had already eaten plenty. Great experience, beautiful restaurant and concept and the prices are unbeatable, less than 25 euros per person including the service!
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Looking for an English etiquette teacher in Cambridge
- or -Post a project like this
£15/hr(approx. $20/hr)
- Posted:
- Proposals: 1
- On-site in Cambridge, GB
- #679474
- Expired
Experience Level: Intermediate
We are looking for an English etiquette teacher to teach a group of international students for 3 hours at Cambridge's Anglia Ruskin university on the 2nd of march between 9am-12pm.
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Electrical Engineering Intern
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• Electrical Part selection and evaluation
• Assist in Design, prototype, and test product operation, features or modifications
• Review test results, procedures and BOM with senior team member
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Welcome To Coast Elite Gymnastics Academy
Coast Elite will be closing at 6:30pm on October 31st for Halloween! Make-ups can be scheduled at the front desk!
Open Gym Punch Passes have arrived and our all new newsletter has gone out!
Come train with Malia, a mom and your personal trainer, in our all new Baby and Me Bootcamp classes!
Our baby and me group workout is designed to get your heart rate up, increase flexibility, and tone your muscles fast! This class is generated towards parents with babies 4 weeks of age to pre-crawling. There is a 15 parent per class maximum, so visit the front desk today to secure your spot!
Classes are Saturday mornings 9am - 9:30am beginning October 20th. It is $10 per parent and child duo and an additional $5 to add another child.
Recreational classes at Coast Elite help your child to become stronger, increase their flexibility and learn the basics of gymnastics in a fun, safe and supportive environment.
For girls and boys ages 5-12 - Beginning and intermediate gymnasts alike will find our gymnastar class fun and challenging. This class introduces gymnastics terminology and basic skills on all four gymnastics events - plus tumble track! There are four levels of skills in gymnastar, and students will have the opportunity to show them off in our twice-yearly class show.
Coast Elite also offers Women's Competitive Gymnastics - Coast Elite Gymnasts have recieved 6 consecutive years of full ride division one gymnastics scholorships and verbal commitments to University of Florida, University of Alaska, University of Denver, University of Iowa, University of Missouri, and University of Alabama.
Coast Elite Gymnastics Academy is located in Fort Myers, Florida. We offer preschool, recreational, and women's competitive gymnastics programs. Cheer tumbling, birthday parties and camp programs are also available! Please explore our site and see what's happening at Coast Elite!
Coast Elite Gymnastics Academy - 6360 Arc Way - Fort Myers, FL 33966 - 239.936.8467
email: email@example.com


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Quebrada Seca Water Project
History Logs
Project Description
North America
Country: Guatemala
Location: Quebrada Seca
Total Budget:
Area of Focus: Water and sanitation
View OnlineProposal Form
The location if this project is in the community of Quebrada Seca, which is part of the village of Oquen, municipality of Jocotán, department of Chiquimula, Guatemala.
The community of Quebrada Seca is comprised of 574 inhabitants, made up of 167 families in 167 homes. Currently the families of the community obtain water from small wells or streams, which are contaminated. This contamination is causing families to suffer from gastrointestinal diseases, especially affecting the infantile population.
This project will build a water distribution and purification system. This system will provide clean water for the community, thus decreasing illnesses, and improving the overall well being of community members.
The project will consist of building a spring collection box, a water distribution tank, a purification system in tank, piping from the collection box to the distribution system and piping from the distribution tank to individual houses.
Project funds will be used to purchase materials for the project, provide hygiene training for community members and management/evaluation of project. The local municipality will also provide project management and skilled labor. The community will provide unskilled labor.
The timeline of project is approximately eight months.
The Rotary Club of Chiquimula, the Rotary Club of Fort Collins and Rotary Club of Burlington North, along with various other Rotary clubs have been working with this and neighboring communities for several years. There have been numerous site visits already, and a trip is planned for January 2019 which will include members of the Rotary Club of Fort Collins. This project will support past and future efforts as part of the community's long term plan.
Primary Host Partner
Rotary Club of:
Chiquimula de la Sierra
Primary Contact: Verónica Guzmán
Primary International Partner
District: 5440
Rotary Club of: Fort Collins
Primary Contact: John Trone
Email: firstname.lastname@example.com
Project Status
Need $1,935
This project needs to receive some pledges to go to the next level. Please check the "Financing" tab to see the list of current pledges. Once the amount pledged is equal to the project budget, the status of the project will be automatically changed to "Fully Pledged".
Click here to pledge support for this project.
Project listed for the 2018-19 Rotary Year.
The TRF Grant application number is #1980172.
Proposed Financing
Existing Contributions Towards This Project
Fort Collins (5440)
Remaining Amount to Raise
Additional Club Contribution (Needed) - Add a contribution
Amount Requested from The Rotary Foundation
Note: as of July 1, 2015 there is a 5% additional support fee for cash contributions. This fee does not appear in the financials above because it does not apply if the funds are sent directly to the project account (without going through TRF, and therefore without Paul Harris credit). Clubs sending their cash contribution to TRF must be aware they will have to send an additional 5%.
Project Supporting Documents
Alphabetical with icons
By date with icons
Alphabetical list format
By date list format
[10-Sep-18]Community Assessment
[10-Sep-18]Initial Water Analysis
[10-Sep-18]Materials Cost
[10-Sep-18]Operation and Maintenance plan
[10-Sep-18]Project Profile - Quebrada Seca Water System
[10-Sep-18]Project Timeline - Schedule
[10-Sep-18]Rights to water source and agreement with benefici
[10-Sep-18]Training Plan
[10-Sep-18]Watershed management plan
Project Photos
History Log Entries
by John Trone
System Entry: Creation of project page.
© 2010 Philippe Lamoise - Website design by Philippe Lamoise, D2G Online


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The novel positive-contrast magnetic resonance imaging (MRI) marker C4 consists of an aqueous solution of cobalt chloride (CoCl2) complexed with the chelator N-acetylcysteine (NAC). We evaluated whether the presence of C4 or its components would produce reactive oxygen species (ROS, including hydroxyl, peroxyl, or other reactive oxygen species) in cultured cells. Human cancer or normal cells were incubated with 1% (w/v) CoCl2·6H2O or 2% NAC or a combination of both (1% CoCl2·6H2O : 2% NAC in an aqueous solution, abbreviated as Co : NAC) in the presence or absence of H2O2. Intracellular ROS levels were measured and quantified by change in relative fluorescence units. Student's
Prostate cancer is the most common type of cancer among men in the United States [
Cobalt in its ionized form (Co2+ or Co(II)) has paramagnetic properties that generate positive-contrast signals on T1-weighted MRI. We developed an MRI marker in which cobalt chloride (CoCl2) is complexed with 6 water molecules (H2O) and the chelating antioxidant N-acetylcysteine (NAC). The resulting "cobalt complex contrast aqua solution," or "C4," is being tested for use in MRI-guided seed implantation in men undergoing brachytherapy for prostate cancer [
Cobalt is a naturally occurring element. In humans, a single cobalt atom is the central metal component of vitamin B12, a cofactor and activator of several essential enzymes that is present in most tissues, chiefly in the liver [
The potential toxicity caused by the inadvertent release of cobalt in C4 from temporarily or permanently implanted medical devices is unknown. To reduce the potential body burden of C4 cobalt, we chelated cobalt with NAC, which is known to increase both urinary and fecal excretion of cobalt and decrease cobalt levels in the liver and spleen [
The human prostate cancer cell line PC3 and the human normal tongue cell line Hs-680Tg were obtained from the American Type Culture Collection (Manassas, VA, USA). The human head and neck cancer cell line HN5 was supplied by Dr. Jeffrey Myers (University of Texas MD Anderson Cancer Center, Houston, TX, USA). HN5 and Hs-680Tg cells were maintained in DMEM/F-12 medium (Corning Cellgro, Mediatech, Inc., Manassas, VA, USA). PC3 cells were maintained in RPMI-1640 medium (Sigma-Aldrich, St. Louis, MO, USA). All culture media were supplemented with 10% fetal bovine serum (FBS, Sigma-Aldrich), 100 U/mL penicillin, and 100
Intracellular ROS levels were measured by using OxiSelect Intracellular ROS Assay Kits (Cell Biolabs, San Diego, CA, USA), which can be used to measure the activity of ROS (hydroxyl, peroxyl, and other reactive oxygen species) within a cell, according to the manufacturer's instructions. The assay uses the cell-permeable fluorogenic probe 2′,7′-dichlorodihydrofluorescein diacetate (DCFHDA), which upon diffusion into cells is deacetylated by cellular esterases to form a nonfluorescent compound that is then rapidly oxidized by ROS to create highly fluorescent 2′,7′-dichlorodihydrofluorescein (DCF). The green fluorescence intensity is proportional to the ROS levels within the cytosol [
Opti-MEM (Phenol Red-negative) medium (Gibco) without FBS was used to prepare the working solution of 1000
Each cell sample was assayed in triplicate. Cells were counted with a TC 20 Automated Cell Counter (Bio-Rad Laboratories, Inc., Hercules, CA, USA). A specific number of cells (for HN5, 5 × 103 cells/well; for Hs-680Tg, 8 × 103 cells/well; and for PC3, 1 × 104 cells/well, all cells in 100
Each cell sample was assayed in triplicate. Cells were counted with a TC 20 Automated Cell Counter (Bio-Rad Laboratories, Inc., Hercules, CA, USA). A specific number of cells (for HN5, 5 × 103 cells/well; for Hs-680Tg, 8 × 103 cells/well; and for PC3, 1 × 104 cells/well, all cells in 100
Each experiment was repeated at least three times. Data are presented as means ± standard error of the mean (SEM). Student's
The absolute change in RFU values for the different treatment conditions was defined as the RFUs after treatment minus the RFUs before treatment. In the absence of H2O2 or any treatment, intracellular ROS levels began to increase slightly at 5 minutes and remained high at 60 minutes (for PC3 cells, 29,893 [
Changes in intracellular reactive oxygen species (ROS) levels over time in response to various treatment conditions. Human prostate cancer cells (PC3, (a)), human normal tongue cells (Hs-680Tg, (b)), and human head and neck cancer cells (HN5, (c)) were treated with components of the novel MRI positive-contrast marker C4 as follows: 1% [w/v] CoCl2⋅6H2O, 2% [w/v] N-acetylcysteine (NAC), or the combined Co : NAC solutions (1% : 2% [w/v]), in the presence or absence of 1000
Compared with the untreated control condition, intracellular ROS levels in cells treated with 1% CoCl2·6H2O began to decrease as early as 5 minutes after treatment and remained at similar levels thereafter in all three cell lines (for PC3 cells, 11,329 [
Intracellular ROS levels in cells treated with 2% NAC were substantially lower than in the control condition (
Treatment with Co : NAC (1% : 2%) led to very small amounts of intracellular ROS at 5 minutes after treatment (PC3 cells, 1432 [
Untreated cells showed a slight increase in intracellular ROS levels relative to control cells (without H2O2) at 5 minutes. Notably, ROS levels greatly increased with time in all three cell lines thereafter (at 90 minutes: for PC3 cells, 123,613 [
In the presence of H2O2 (1000
In the presence of H2O2 (1000
Treatment of cells with Co : NAC (1% : 2%) in the presence of H2O2 (1000
Compared with untreated cells, there was no histopathologic evidence of changes in cell morphology at 90 minutes after treatment with the greatest clinical exposure concentration of C4 or its components (1% CoCl2·6H2O, or the 2% NAC, or the Co : NAC [1% : 2%]) (Figure
Cell morphology after various treatment conditions. Human prostate cancer cells (PC3), human normal tongue cells (Hs-680Tg), and human head and neck cancer cells (HN5) were treated with the greatest clinical exposure concentration of the novel MRI Co : NAC positive-contrast agent for C4 marker or its components (1% [w/v] CoCl2⋅6H2O, 2% [w/v] N-acetylcysteine (NAC), or the combined Co : NAC solutions (1% : 2% [w/v])). At 90 minutes after treatment, cell morphology pictures were taken with a bright field Evos XL core microscope (AMEX 1000, Life Technologies, Carlsbad, CA, USA) at ×10 magnification. Controls (Con) were untreated cells.
In this study, we used a well-established ROS assay, which can be used to measure ROS (hydroxyl, peroxyl, and other reactive oxygen species) activity within a cell, to evaluate the influence of C4 and its components on the intracellular levels of ROS. The maximum tolerance concentration (1000
Ionized cobalt [Co2+, or Co(II)] can generate ROS [
In the current study, we observed to our surprise that 1% CoCl2·6H2O, one of the components of the MRI-compatible marker C4, could also reduce background ROS levels in all three cell lines. Even though there was H2O2-related ROS generation in the presence of 1% CoCl2·6H2O, those ROS levels were significantly decreased in HN5 cells (by up to 55.4%), Hs-680Tg cells (by up to 60.8%), and PC3 cells (by up to 51.5%) over time (30–90 minutes after treatment).
Our study did have limitations, since the conclusions were based on the investigation of one human prostate cancer, one human normal tongue, and one human head and neck cancer cell line under different treatment conditions. Further studies with more cell lines and in vivo models are warranted.
We conclude that, in human prostate cancer PC3 cells, human normal tongue Hs-680Tg cells, and human head and neck cancer HN5 cells, significant DCFH oxidation does not occur in the presence of CoCl2 or NAC alone or in combination; and induced (by the presence of H2O2) DCFH oxidation is blocked by CoCl2 and NAC and by Co : NAC. These findings provide support for the safe use of C4, in which 1% of the component CoCl2·6H2O is complexed with 2% of the chelating antioxidant NAC as a positive-contrast MRI marker for men with prostate cancer undergoing brachytherapy.
S. J. Frank and K. S. Martirosyan are cofounders of C4 Imaging, LLC. S. J. Frank is an advisory board member and consultant for Varian Medical Systems, Inc. All other authors declare no conflicts of interest.
This work was supported in part by Cancer Center Support (Core) Grant CA016672 from the National Cancer Institute to MD Anderson Cancer Center, the Prostate Cancer Foundation, the University Cancer Foundation via the Sister Institution Network Fund, the Institutional Research Grant program, and startup funds to Steven J. Frank from the University of Texas MD Anderson Cancer Center. The authors would like to thank Jibin Ding from the Department of Integrative Medicine and Lisa Norberg from the Department of Cancer Biology at MD Anderson for technical assistance. They also thank Christine F. Wogan from MD Anderson's Division of Radiation Oncology for editorial assistance.


text:
Alex Gordon
Jesus was a carpenter. Hitler was an artist. Einstein worked in a patents office, and flunked out of school. In life, things are very often not what they seem. Which brings us to right now. Look around you. Do you feel safe? Are you still answering the phone directly, when it rings? It may be the time to stop. Because outside, strange and sinister forces are stirring. And all they want to do - is sell you something! Sell, sell, sell! It's become manic, and unstoppable. It would be funny if it were not so tragic. So keep your eyes open, and lock the front door tight! Because we never really know who may be the next to knock!


text:
A Modest Proposal and Other Writings
Want it by Tuesday, October 23
Order now and choose Expedited Shipping during checkout.
Same Day shipping in Manhattan. See Details
A new selection of works by Britain's foremost prose satirist
Easing poverty in Ireland by eating the children of the poor was the satirical "solution" suggested by Jonathan Swift in his essay "A Modest Proposal" (1729). Here Swift unleashes the full power of his ironic armory and corrosive wit, striking his targets-the ruling class and avaricious landlords-with deadly precision. This masterly essay is accompanied by a generous selection of prose works, among them humorous pamphlets critiquing British rule in his native Ireland, articles and correspondence, a loving eulogy to his beloved "Stella," the daughter of a house servant whom he mentored, and pieces on such diverse subjects as the nature of broomsticks, the joys of punning, and comical rules for servants.
For more than seventy years, Penguin has been the leading publisher of classic literature in the English-speaking world. With more than 1,700 titles, Penguin Classics represents a global bookshelf of the best works throughout history and across genres and disciplines. Readers trust the series to provide authoritative texts enhanced by introductions and notes by distinguished scholars and contemporary authors, as well as up-to-date translations by award-winning translators.
Product Details
|Penguin Publishing Group
|Publication date:
|Sales rank:
|Product dimensions:
|5.00(w) x 7.70(h) x 1.00(d)
|Age Range:
|18 Years
About the Author
Carole Fabricant is Professor of English at the University of California, Riverside. She is the author of Swift's Landscape and has published widely on a number of eighteenth-century writers, including Alexander Pope, Edmund Burke and Bishop Berkeley, as well as on topics such as landscape gardening, travel, tourism and questions of colonialism and race in the eighteenth-centruy, especially as they relate to British-Irish relations during the period.
Customer Reviews
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text:
For 1957, the Turnpike Cruiser was the premium model offering from Mercury. In addition to its unique features, the car was further differentiated from other Mercury models by a gold anodized trim strip in the car's rear fin. It came standard with an automatic transmission and a 368-c.i.d. engine producing 290 horsepower (220 kW); this engine was optional on other Mercurys. A tachometer was available. Safety features such as an impact absorbing, deep-dish steering wheel, front seat stops (to keep the front seat from breaking away) and safety door locks were standard, while seat belts and a padded dash were optional.
Fuji X-T1
18-55 @ 55mm
1/280 sec
Lightroom Classic


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