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Hanson is a pop/rock band formed in Tulsa, Oklahoma, by brothers Isaac on guitar, vocals, and piano; Taylor on keyboards, piano, guitar, drums, and vocals and Zac Hanson on drums, piano, guitar, and vocals. The brothers are best known for their 1997 hit song "MMMBop" off their debut album, "Middle of Nowhere," which earned the trio three Grammy nominations.
The Hanson brothers began by jamming in their garage and independently recorded two albums: "Boomerang" (1995) and "Mambo" (1996). The brothers managed to get a slot at South By Southwest and were spotted by their future manager, Christopher Sabec, who was instrumental in getting the trio signed to Mercury Records. Their debut album, "Middle of Nowhere," appeared in 1997 and the brothers became an instant sensation. Three Grammy Awards followed in 1998 for Record of the Year, Best New Artist and Best Pop Performance by a Duo or Group with Vocal.
2000 marked the release of the band's seventh studio album, "This Time Around," however, Island Def Jam Records were in financial constraints at the time and poorly promoted the album, resulting in low record sales. The band financially supported themselves while on tour that summer and fall of 2000 in an effort to promote their album. Hanson left Def Jam Records shortly thereafter in an effort to have more creative freedom over their music.
The brothers also started up their own record label, 3CG Records, and began to release their albums themselves. 2009 saw the brothers record "Shout It Out," which peaked at #30 on Billboard's 200 Albums chart and #2 on the Indie chart.
MediaNet's Content Information Solutions bring quantity and quality to your entertainment content needs.
MediaNet mastered Content Fulfillment Solutions over the last ten years. We offer many tools and implementation methods.


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The country's tax office has appealed a ruling handed down by India's Supreme Court last month, in a last-ditch attempt to bill Vodafone $2.5bn (£1.3bn) for its 2007 acquisition of a 67pc stake in Hutchison Whampoa's Indian mobile unit.
In January's ruling, the Supreme Court said the tax office did not have jurisdiction over the deal because it was between two overseas companies. One of the three judges presiding over the case said it would amount "to imposing capital punishment for capital investment".
The decision marked a major victory for Vodafone, which had spent five years battling the Indian tax office. The ruling also reassured other multinationals expanding in India, who were fearful they could face similar charges.
However, the tax office on Friday exercised its right to call for a review within 30 days of the original Supreme Court judgment.
Vodafone said in a statement that the Supreme Court had ruled "clearly and unambiguously" that there was no tax due.
The appeal will go before the same three judges and is expected to be complete within six weeks.
Vodafone plans to make an initial public offering for its Indian business in 2013, but says a rewrite of the tax rules would cast doubt on this.

subset: commoncrawl


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Hepatitis C Facts
So what is this stuff?
Hepatitis C is one of the lesser-known STD's. Yet, some 200 MILLION people are estimated to have it, worldwide. (To give you some perspective, the US population is only 300 million.) A lot of people, huh. This disease starts out slowly, presenting symptoms most people would ignore. Eventually, however, it can lead to liver failure, liver cancer and a very painful death. There is no a vaccination, and while some purport a cure is possible, the jury is still out.
How do I get it?
Blood to blood contact is the simplest way. And because the virus can live on inanimate objects for a certain period of time, it's actually possible to get this just by sharing a toothbrush with someone. Or a razor. Let me be more specific – It's suspected this virus can live at room temperature for as long as 4 days. Think about that the next time you touch something and you don't know where it's been! This makes tattooing a possible vector – make sure your tattoo parlor adheres to universal precautions. Sexually, it's less commonly transmitted, but it's certainly possible. Anal sex or rough vaginal sex make a person more susceptible due to increased possibility of tearing and blood exchange. They say it's not known to spread via cunnilingus or fellatio – but I can't say I want to take their word for it.
What are the symptoms?
In the first year, next to nothing, unless you're already immuno-compromised. Beyond that, it would resemble the flu, usually. In most cases the symptoms wouldn't seem out of the ordinary, and, in fact, most diagnoses are coincidental. Otherwise, liver problems are the most common, as this virus pretty much targets that organ. People with full-blown Hep C could be jaundiced, as well.
What's the worst that can happen to me?
You can die a very painful death as your liver shuts down. According to the CDC, about 85% of infected persons will end up with chronic infection. 70% will wind up with chronic liver disease. 20% could develop cirrhosis within 30 years. And, in case you're not familiar with the latter, it's a rather painful way to die.
How do I get tested?
It's a very simple blood test. Your doctor or local STD clinic would be happy to test you. It's important to note there is a WINDOW here. You can end up with a false negative if you test within 3 months of exposure. Your best bet is to wait until you've passed the 3 month mark before testing. Unless you want to do it twice, which is certainly not unheard of.
What if I have it?
In early 2007 doctors claimed that a combination of Interferon and Ribavirin could cure people of this virus. That gives hope to the 300 million living with it. If these don't work for you however, you'll need to think about the following:
You'll have to start taking precautions to prevent transmission to others. That said, the CDC actually doesn't recommend changing sex habits if already in a monogamous relationship that doesn't utilize condoms. It would seem the virus is very rarely passed this way. If your partner is immuno-compromised, however, it would be wise to start using them. Condoms do prevent Hepatitis C transmission, and peace of mind is probably worth this much. You'll need to change your diet, and you'll need to restrict alcohol intake. Your liver will need all the help it can get. You will also likely need to start treatment – and since there isnt't a cure, it's mostly experimental these days. And expensive. And it can come with lots of side-effects.
How can I prevent it?
Use the same precautions you would use for preventing HIV transmission, and then also make sure you don't share things that could have come in contact with blood. Razors, toothbrushes, nail files, nail clippers, etc. It should go without saying one should not be injecting drugs, but if you are, avoid sharing needles.
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Mr Sullivan said he was buoyed by the overwhelming positive nature of the meeting.
"Everyone I met realised the opportunity to embrace the Royal Commission and be part of a healing, reconciliation process. To let the truth come forward so victims could get a fair go.
"Many important issues were discussed, particularly the complex issue of retrieving documents and files for the Royal Commission.
"Throughout the day we also talked about the process of the Royal Commission and our understanding of the public and private hearings," Mr Sullivan said.
Bishop Putney said the meetings provided valuable information about the Royal Commission and the role of the Truth Justice and Healing Council.
"The Catholic Church has committed to being open and transparent with the Royal Commission and this is a position I back 100 per cent.
"During the Royal Commission the stories of many victims will be heard.
"These stories will be traumatic and confronting but victims need to be listened to and they need to know the Church is ashamed and repentant about how they have been treated.
"Once again I offer my sincere apologies to anyone harmed in our diocese and I commit to fully engaging with the Royal Commission to ensure the truth is heard and victims receive justice."
The Truth Justice and Healing Council has been established by the Catholic Church to help the Church response to the Royal Commission into the Institutional Responses to Child Sexual Abuse.
Its role is to oversee the Church's engagement with the Commission, to develop new policies to protect young people and to ensure the Church responds to any future complaints appropriately with justice, putting the needs of victims first.
Media contact Michael Salmon 0417 495 018


text:
Julia is in her second year of a postgraduate medical degree at the University of Sydney. She survived the grueling entrance exam and interview process and is now enjoying learning all about the human body while making the most of the social side of the course.
My father was a vet and I watched him do consults, treat patients and talk to clients. I found it an interesting process to have someone come in with a problem and then talk with them, look at their animal and try to solve the problem. I've also always been interested in the human body and how it works.
Kids always have exciting ideas about what they want to be and I had all those as well, but I think I actually always imagined myself doing medicine in the end.
No, I never wanted to do undergraduate medicine. I was too interested in other things as well, like languages and politics, so I decided to do an Arts degree. I got to do a bit of everything: chemistry, philosophy, maths, economics, politics, and languages; Spanish, Chinese and French. It didn't really lend itself to a smooth transition into medicine, but then again the people in my course now come from all sorts of fields.
There are fewer universities offering undergraduate medicine now, but if you did want to go straight into medicine in first year you need to sit the UMAT (a problem solving, no knowledge required test) and attend an interview. It's a longer course with a different structure than the postgraduate course because they start out with a bigger focus on basic sciences.
It's called the GAMSAT, which stands for Graduate Australian Medical School Admission Test. It is assumed that people sitting the GAMSAT have a knowledge of Year 12 physics and first-year university biology and chemistry.
It's an interesting test because there are three sections with the science section weighing the most. Then you have to write two essays on social science questions like 'what is democracy?' and 'crime and punishment'. There is also an English comprehension section.
Some people sit it with no preparation, while others opt to study for a year in advance and others attend courses on how to answer the questions in the GAMSAT. I borrowed some notes from a friend who had sat it, did a couple of practice exams, and read some sample essays and English comprehension questions.
You put in three preferences for universities and, depending on your GPA and GAMSAT result, one of them might offer you an interview. Sydney Uni had a new format of interview called the multiple mini interview where we spent a certain amount of time at eight stations answering different questions. They were all scenario-based questions on ethical and professional aspects of medicine.
GPA stands for Grade Point Average, that is an indication of a student's overall performance in their course.
It's difficult to prepare because they are scenario based. A lot of people went to courses to practice, but a doctor gave me the advice to read up on medical ethics, professionalism and the basic principles of medicine. Things like why a patient should have autonomy, the role of the doctor and the patient-doctor relationship.
First and foremost, I think that being your own individual is important – don't just say what you think the examiners want to hear. I think they are looking for people who have a solid concept of what is ethical and for people who are well-rounded with interests beyond medicine. They are also looking for people who are deep thinkers and can communicate their ideas.
I don't think you realise just how much work it is until you get into it. You can pass the exams and fulfill the requirements, but ultimately it's about coming out a competent doctor. The course is pretty practical. From the outset you spend one day a week at a hospital with clinicians. We learn how to take patient histories, physically examine the patient, give injections and take blood pressure.
I really like learning about the human body and I also really like the communal side of the course – the fact that we are part of a group and all working towards the same goal.
I always feel like I never know enough. There is an infinite amount to learn and sometimes you can't understand one part until you understand the rest. It's not about being lazy, but it takes time for all the pieces to fit together and sometimes it can be frustrating.
Ultimately I hope to become a competent doctor who can diagnose and treat illnesses and care for patients. I think it would be satisfying to become a rural GP where you see your patients for many years and see them grow up. You are also servicing a community which really needs and values your skills. On the other side of it, I really do find some of the specialties interesting.
Some people know from day one that they want to be an orthopedic surgeon or a cardiologist, but all the way through the degree you have opportunities to focus on areas of interest. Actually choosing a specialty doesn't come until years in.
Firstly you need to understand that medicine is a life choice – it's not the kind of job you leave at 5 o'clock in the evening and go home without a worry on your mind. Also, talk to people who are working in medicine and ask them about their experiences.
It's a lot of hard work to get there, so it's not something to do on a whim. That said, we all really enjoy it! I had a tutor in his seventies at hospital who came bouncing in every Monday morning saying how excited he was to be there and how much he loved medicine. From what I've seen, I think medicine can be an intensely exciting and satisfying profession.
Payment plan


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Kids Fishing Day!
The Parks & Recreation Dept. will host our 13th Annual Weldon Spring Kids Fishing Derby on Saturday, June 10th from 9:00 a.m. – Noon. It doesn't seem possible that the first kids fishing event was held here back on Saturday, May 22nd, 2004. It has certainly grown each year into an outdoor event the kids now plan for. It seems there is nothing like enjoying the fresh outdoor air while catching fish and eating grilled all beef hot-dogs. Boys & Girls ages to 16 years old are invited to attend this outdoor event along with a parent, guardian or grandparent. Fishing, bait, photos, soda, all beef hot dogs & water are all FREE. Our lake remains "catch and release" but the kids don't mind. They love to sit by the lake with their parents or grandparents waiting to catch "the BIG one". If you have kids or neighbors under the age of 16 that would like to get out in the fresh air and enjoy nature, you may want to plan on bringing them up on June 10th from 9 o'clock until noon and have some good old fashioned fun. Remember, Kids Fishing is Catching On."
The City will provide the bait and have "experts" on hand to help the kids bait their hooks and handle the fish again this year. Our Park Guys, Richard & Howie along with Mayor Licklider look forward to helping the kids bait their hooks and take photos. Each child will receive a gift pack at the end of the event. So many of the kids brighten up for pictures with their first fish, or the biggest fish or who catches the most fish. Photos will then be posted on the city's website for all to view.
If weather causes cancelling that day a new date will be announced on the city website or can be obtained by calling our City Parks Department at (636)441-2110 ext. 104.


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Perfect for ageing, mature hair, label.m Therapy Rejuvenating Shampoo (150ml) is formulated with the Rejuven-8™ Complex, which contains eight of the most technologically-advanced anti-ageing ingredients that will leave your hair feeling strong, lustrous and full of vitality. Dull, weak hair will be completely transformed. - L.M.
Directions of use:
- Apply to freshly shampooed hair
- Leave for 2-3 minutes
- Rinse thoroughly


text:
Gain Respect, Win Others over, and Achieve the Success You've Longed For!
In study after study, business leaders say it again and again: weak communication skills are the number one barrier to promoting employees. That means the most important skill you can bring to any job is the ability to communicate well.
When you participate in this on-demand training, you'll learn everything you need to know to become an outstanding communicator. You'll learn how to get support from everyone … you'll discover the poise and presence you need to speak confidently in meetings … and you'll even eliminate the behaviors that may be sabotaging you right now!
You already know that polished communication techniques are essential if you want to work more effectively with others, create better workplace relationships, and build on your potential. Whether you work with a handful of people or hundreds, the practical skills you'll learn will guarantee that will help you in every situation that requires communication finesse.
Don't take chances with your career! Sign up for this on-demand seminar today!
Interested in having access to our complete line-up of on-demand seminars?
With STAR12, it's more affordable than you might think!
Call 1-800-258-7246 or learn more here.
On-Demand Seminar Details:


text: hey everyone, I have had a porn site for nearly a year now. It doesn't have that many videos (48) but that is because I am uploading every video now. It did have 30k videos but they were all embedded an you cant monitor that many videos for quality. I am slowly building the traffic up now since it was down for a while, my best day so far was 378UVs an then it dropped by 200 yesterday. I haven't made a single dollar of the website an I am not surprised. How much traffic does one have to have on a porn website for it to convert? Cheers


text: I have just started promoting a couple of CPA offers. From lots of threads here, I can see that people have been doing well via BlackHat/Craigslist methods. I was wondering what are the chances of getting good profits with simple Whitehat techniques implemented? Is there any chance for that? What I am planning to do: 1) Choose the best paying CPA offers 2) Do some Keyword research to target the high traffic/low competition keywords relevant to that offer. 3) Buy a good keyword rich domain name. Have them unique content put along with the CPA banners/links/opt-ins. 4) Since I am pretty good in KW Research/SEO, it will be easy to rank in first page of Google for these keywords. I can have this scaled to create upto 30 websites/month targeting different offers and might put some PPC into action. Before taking such a leap and investments, I would appreciate any feedback from people who have taken similar whitehat steps and how successful these campaigns turned out to be


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By Josh Stephens, SolarWinds - Whether you realize it or not, you probably already have IPv6 traffic on your network. Not learning how to effectively deploy, manage and secure this traffic would be a huge mistake.
Here's what you need to know -- and do -- to start your transition from IPv4 to IPv6.
Understanding IPv6
First and foremost, you are going to need to educate yourself on the technology and get into full-blown learning mode. There are numerous classes and seminars that will get you ahead of the curve quickly; this will provide you with the basis you need to fully understand the technologies around IPv6 and how to manage them correctly. One of my favorite events is the Rocky Mountain IPv6 Summit.
If books are your learning tool of choice, a couple of good ones are: IPv6 Essentials and IPv6 Security.
This is also a good time to brush up on your fundamentals. I come across my fair share of network engineers who have been getting by without really understanding the underlying technologies. When you decide to start migrating to or adding IPv6 to your network, you really need to have the proper fundamentals first or you will be headed for some really tough times.
Know what you have
The next step is an essential one: you need to conduct an audit. You should have a good idea what you already have on the network, but it's always good to recheck your hardware and software on a regular basis. It's essential to know what you already have that is IPv6 compliant and what isn't. If you attempt to make the move straight over to IPv6 without evaluating, you are not only wasting your time, but could bring down your data center like a house of cards.
Once you complete the audit, you can begin upgrading. For me, I know that I learn best by doing, so you should roll up your sleeves and start working with what you have learned. We already know that we will be faced with a hybrid solution that will be a marriage of IPv4 and IPv6 within our own networks. You should set up test beds within your own network and start migrating a few things into a joint IPv4/IPv6 or "dual stack" solution. You spend some good quality time under the hood in a closed environment and it should become second nature in no time.
Start rolling it out!
A great place to start investigating your IPv6 capabilities is within DNS, as we know it's one of the core technologies that every network engineer should understand and it won't do you much good to bring IPv6 addresses into your network if you can't resolve them to names and vice versa.
Another great place to deploy an early IPv6 network is a "management network" or "telemetry network," as we used to call them in the old days. Network Address Translation (NAT) can be a real burden when it comes to monitoring devices in duplicate or overlapping address ranges, so this may be a great place for you to start moving to IPv6.
While migration to IPv6 won't happen overnight, it's time for you to wrap your mind around all things related to it and come up with a plan to ensure that you are able to roll everything out smoothly.
I hope this tip helps you on your journey to IPv6.
Josh Stephens is Head Geek and VP of Technology at SolarWinds
See also:
IPv6 basics: Getting started with IPv6
What You Need to Know about IPv6
Avoiding the pitfalls when transitioning to IPv6


text:
84B Old Main Street Deerfield
Travel back in time and rediscover the history behind the Patriot's Day holiday and the "shot heard round the world." Revolutionary times will come to life through demonstrations of period crafts and activities, fife and drum music, and a muster. Nathan Hale Ancient Fifes and Drums, Knowlton's Connecticut Rangers and Buckland's Artillery play a lead role in the day's activities.
Historic Deerfield guides and cooks will interpret open hearth cooking, chocolate's role in the military, and powder horn carving in the 1786 Hall Tavern. Horse-drawn wagon rides will transport visitors through the village, and all historic houses will be available for touring. Visitors can make a flag to wave during the afternoon parade, and then take it home as a memento. A "Liberty Quest" will be available for adventurous visitors who will receive a prize once they complete it. The event will also have family-friendly food available.


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NEW YORK, July 27, 2009 — The Danny Tanner "Full House" fans remember is long gone! Bob Saget is outspoken and pushing the envelope more than ever in the Network Television Premiere of "Bob Saget: That Ain't Right," debuting Friday, August 7 at 11:00 p.m. on COMEDY CENTRAL.
Bob Saget leaves nothing to the imagination when he hits the stage full throttle, covering cutting edge topics with his fearless delivery in this all-new stand-up special. Saget does not hold back as he questions even the sexual orientation of his former co-stars on "Full House." Want to skip out on an all-new hour of laugh-out-loud comedy That ain't right! Tune in to COMEDY CENTRAL Friday, August 7 at 11:00 p.m.
COMEDY CENTRAL, the only all-comedy network, currently is seen in more than 95 million homes nationwide. COMEDY CENTRAL is owned by, and is a registered trademark of, Comedy Partners, a wholly-owned division of Viacom Inc.'s (NYSE: VIA and VIA.B) MTV Networks. COMEDY CENTRAL's Internet address is www.comedycentral.com. For up-to-the-minute and archival press information and photographs visit Press Central, COMEDY CENTRAL's press web site at www.comedycentral.com/press.
MTV Networks, a unit of Viacom (NYSE: VIA, VIA.B), is one of the world's leading creators of entertainment content, with brands that engage and connect diverse audiences across television, online, mobile, games, virtual worlds and consumer products. The company's portfolio spans more than 150 television channels and 350 digital media properties worldwide, and includes MTV, VH1, CMT, Logo, Harmonix, Nickelodeon, Nick at Nite, Noggin, The N, AddictingGames, Neopets, COMEDY CENTRAL, Spike TV, TV Land, Atom, Gametrailers and Xfire.


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Flexible support packages are developed in partnership with people with a disability, and their families and carers, to plan for and implement flexible supports tailored to individual needs and priorities.
The packages provide discretionary funding and/or short term case management to support individuals, families and carers. The development and implementation of a flexible support package is based on a self-directed planning and support approach. The principles of the self-directed approach are self-determination, choice, inclusion, transparency, accessibility and citizenship.
When considering an application for Flexible Support Package funding, the following indicators will be taken into account:
Applicants may not be approved the full amount of funding they have applied for.
All Applications must be accompanied by a Quote for the requested funding.
All applications will be considered and a written response will be provided within 30 days
If you are interested in attending or wanting to know more, contact the Aged and Disability Services Information, Assessment and Referral Officer (intake) on 1300 367 700.


text:
Book Title: Collection of engravings of chapels
Author: Wesleyan Methodist Church
Image Title: Trinity Wesleyan Chapel, Macclesfield
Description: Trinity Wesleyan Chapel in Macclesfield.
Click here for additional images available from this book.
For information on licensing this image, please send an email, including a link to the image, to email@example.com
This image is made available by the generous contribution of E. Rhodes and Leona B. Carpenter Foundation.


text:
Hi I posted about whether I'm now on too much levo I'm pregnant 17 weeks and taking 125mcg have been since 4 ish weeks but every blood test my tsh has dropped last test was 0.6. well anyway I take my levo at 11.30pm every night well last night I woke at 1am feeling pumped up and my heart was beating very fast and my leg and arm muscles were twitchy and my head was racing. I got up feeling very awake all of a sudden I tried a glass of water and deep breathing but it took about twenty minutes for this extremely pumped up feeling too past and longer still for me too relax as I very panicked but this strange feeling.
My hubby thinks I should reduce back too 100 as I felt similar when my starting dose was 125mcg rather than 50.
Any advice please it was horrible feeling like I was high on drugs or something should I reduce down now and have bloods done next week?
Would this have also hurt the baby? Thanks


text:
Montreal Online Classifieds, Deals & Sales
Adpost.com Classifieds
Canada Classifieds @ Adpost.com Classifieds - Canada Classifieds for over 1000+ cities, 500+ regions worldwide & across Canada - free,canadian
Annonces classées à Montreal - Montreal Free Classified Ads
Free Classified ads in Montreal, Quebec, Canada for used cars, apartments, jobs, services, electronics, community events and garage sales and more. Here you can find ads to rent furnished apartments, find sublets, buy and sell used furniture, sell car parts, used tires.
buysell.com.... Canada's leading classified ad site. Browse and keyword search 80,000+ ads weekly from Buy & Sell, Bargain Finder, and Boat Journal.
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Kijiji Montreal Classifieds: Free Classified Ads for Montreal
Kijiji Montreal has local buy & sell, furniture, cars, pets, apartments and more. Kijiji is Canada's most popular classifieds with over 250,000+ free ads!
Montreal Classifieds
Are you looking for a place to sell/buy products? Well here you can, people from Montreal get together and trade various items. Find everything from cars, apartments, jobs, services, electronics, community events, concert tickets and much more.


text:
Experimental Diabetes Research
Volume 2012, Article ID 316384, 4 pages
Increased Caspase-3 Immunoreactivity of Erythrocytes in STZ Diabetic Rats
1Department of Pathology, School of Medicine, Dicle University, Diyarbakır 21000, Turkey
2Department of Immunology, School of Medicine, Dicle University, Diyarbakır 21000, Turkey
3Department of Hepatology and Transplantation, Division of Gene and Cell Based Therapy, School of Medicine, King's College London, London SE5 9NU, UK
4Department of Medical Pharmacology, School of Medicine, Dicle University, Diyarbakır 21000, Turkey
5Department of Internal Medicine, Division of Endocrinology, School of Medicine, Dicle University, Diyarbakır 21000, Turkey
6Department of Internal Medicine, Division of Endocrinology, School of Medicine, Süleyman Demirel University, Isparta 32260, Turkey
Received 16 February 2012; Accepted 26 March 2012
Academic Editor: Pietro Galassetti
Copyright © 2012 Uğur Fırat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Eryptosis is a term to define apoptosis of erythrocytes. Oxidative stress and hyperglycemia, both of which exist in the diabetic intravascular environment, can trigger eryptosis of erythrocytes. In this experimental study, it is presented that the majority of erythrocytes shows caspase-3 immunoreactivity in streptozocin- (STZ)-induced diabetic rats. Besides that, caspase-3 positive erythrocytes are aggregated and attached to vascular endothelium. In conclusion, these results may start a debate that eryptosis could have a role in the diabetic complications.
1. Introduction
Hyperglycemia and oxidative stress are the prominent features of diabetes mellitus (DM) and seems to play a crucial role in DM-related microvascular complications. In addition, complications of DM like nephropathy, retinopathy, and macrovascular disease are associated with anemia [1, 2].
Eryptosis, a term used for apoptosis of erythrocyte, is triggered with osmotic shock, oxidative stress, or energy depletion [3]. Moreover, eryptosis is characterized with cell shrinkage, membrane blebbing, membrane phospholipids scrambling, and phosphatidylserine (PS) shifting from inner to outer membrane of the erythrocyte [4]. It is demonstrated that death receptor initiated pathway of apoptosis takes a role in eryptosis involving Fas, caspase-8, and caspase-3 [5]. Caspase-3, an executioner caspase, immunoreactivity is observed in the lysate of erythrocytes obtained from type 2 DM patients [6]. Besides that, previous reports show the evidence that eryptosis underlies anemia and microvascular injury both of which may be related with endothelial adhesion and increased aggregation of erythrocytes, in DM patients [3, 7–9].
In this study, it is presented that increased caspase-3 activity is detected in erythrocytes in the vasculature of cerebrum and cerebellum of STZ-induced DM rats. In other words, eryptotic erythrocytes number is increased in DM rats. This finding can explain the anemia and the underlying or accompanying factors of microvascular injury, such as erythrocyte aggregation and endothelial erythrocyte adhesion in DM.
2. Materials and Methods
2.1. Animals
Female Wistar Albino rats are obtained from the Laboratory Animals Facility of Dicle University. In this study, rats are handled in accordance with the Animal Welfare Act and the Guide for the Care and Use of Laboratory animals prepared by the Animal Ethical Committee of Dicle University. Rats are distributed into following groups with each: non-DM group and DM group. Rats in non-DM group received citrate buffer intraperitoneal (i.p.) injections. Rats of DM group were injected with STZ (50 mg/kg, i.p.; in 0.1 M citrate buffer, pH 4.5) for induction of DM. Blood glucose level of rats in DM group is confirmed before sacrifice and it is over 250 mg/mL. Thirty days after i.p. administration rats are executed for the analysis.
2.2. Biochemical Analysis
The excised cerebrum for biochemical analyses were weighed, immediately stored at −80°C. The cerebral tissues are perfused with 1.15% ice-cold KCl (w/v) and sliced into minute pieces then homogenized in five volumes of the same solution. The homogenate is centrifuged at 14.000 rpm at 4°C for 30 minutes (min). The supernatants are used for the assay. Lipid peroxidation level, indicator of oxidative tissue damage, in the cerebrum is defined with malondialdehyde (MDA) amount as mentioned by Ohkawa et al. [10].
2.3. Immunohistochemical Staining
Cerebrum and cerebellum are fixated in 10% formaldehyde for 48 hours. Then, they are dehydrated and embedded in paraffin. Paraffin blocks are sliced in 4 μm thickness with microtome. Tissue slices are located on positive-charged glasses and incubated at 60°C for 60 min to deparaffinize. Then, slides are treated with xylene ( min) and hydrated with alcohol. Antigen retrieving process is done in citrate buffer (10 mM Citric Acid, 0.05% Tween 20, pH 6.0) by boiling and cooling down (x3) in microwave oven. After this and every other processes slides are washed with Phosphate-Buffered Saline twice for 5 min each. Endogenous peroxidase blocking is done with Peroxide Block (ACA500, ScyTek, UT, USA) for 10 min at room temperature (RT). Then, slides are treated with Super Block (AAA125, ScyTek, UT, USA) for 20 min at RT. Then, slides are treated with rabbit anti-human Caspase-3 polyclonal Antibody (1 : 750) (cat#. GTX73090, Gene Tex, Inc.; CA92606, USA) cross reacting with rat caspase-3 for 20 min at RT. Then, biotinylated SensiTek polyvalent antibodies (ABF125, ScyTek, UT, USA) are applied for 20 min at RT before SensiTek HRP, streptavidin-HRP complex (ABG125, ScyTek, UT, USA) treated for 20 min at RT. Finally, AEC Chromogen/Substrate Bulk Kit (ACJ125, ScyTek, Utah, USA) working solution is applied for 10 min at RT. Counterstaining is performed with Mayer hematoxylin (cat#. 05-M06002, Bio-Optica, Milano, Italy). Slides are evaluated under the light microscope (Nikon ECLIPSE 80i, Japan) at ×400 magnification by a pathologist blinded to study groups.
2.4. Statistics
Caspase-3 positive and negative erythrocytes are counted in vascular spaces at randomly selected 8 regions for each slide. The averages of percentage of positive cell are calculated for each slide. Then, the means of percentages of positive cells of the groups are compared with Student's t-test. The difference of the means of MDA levels is also calculated with Student's t-test. Data are presented as mean ± S.D.
3. Results
In this study, MDA levels, showing lipid peroxidation representing oxidative tissue destruction, in cerebral tissues are significantly higher in DM group than non-DM group, nmol/gr protein, and nmol/gr protein, respectively (). In addition, immunohistochemical staining of the cerebral and cerebellar tissues demonstrates that a few number of erythrocytes show immunoreactivity to caspase-3 in non-DM group (Figure 1(a)), that is physiological outcome of senescence of erythrocytes, possibly. However, the number of capase-3 immunoreactive erythrocytes is elevated in DM group (Figure 1(b)). In addition, majority of the erythrocytes with caspase-3 immunoreactivity attached each other in DM group (Figure 1(c)). Furthermore, these aggregated erythrocytes adhered to endothelium of the vessels (Figure 1(c)). What is more, some of the vessels are totally occluded with caspase-3 positive erythrocytes in these rats in DM group (Figure 1(d)). The statistical picture of our finding is as follows: % of the erythrocytes show immunoreactivity to caspase-3 in DM group; nonetheless, % of the erythrocytes stained with caspase-3 in non-DM group (Figure 2). In addition, the mean of percentages of caspase-3 positive cells is significantly different in DM group than other group (). These findings suggest that eryptosis, ignited with either high serum glucose level or oxidative stress or bought of them and defined with prominent caspase-3 immunoreactivity, is a considerable underlying cause of the diabetic complications, such as microangiopathy and anemia.
4. Discussion
In this study, in brief, caspase-3 immunoreactivity in erythrocytes, aggregation, and endothelial adhesion of erythrocytes are shown with immunohistochemical staining of cerebral and cerebellar tissues in the diabetic rats. In diabetic rats, presence of caspase-3 immunoreactivity in erythrocytes may be an indirect evidence of eryptosis accompanying conditions like PS exposure and caspase-8 activity.
Up to date, according to our literature search, this is the first report that demonstrates caspase-3 activity in erythrocytes with immunohistochemical study in diabetic rat. Beside that, there are two other reports supporting our finding, caspase-3 activity in erythrocytes [6, 11]. First report presents that caspase-3 activity is significantly higher in type 2 DM than healthy subjects [6]. Second report shows that even erytrhocytes of type 2 DM patients without chronic kidney disease are stained with annexin V, bind PS, and show early apoptotic cells [11]. Our results suggest that hyperglycemia, a kind of hyperosmalar state, and oxidative stress may initiate the cascade of eryptosis. Hyperglycemia and oxidative stress are a well-documented trigger of eryptosis; however, how they do succeed that is not clearly demonstrated yet [6]. One explanation of that may be death receptor based. Previously, it was reported that Fas, caspase-8, and caspase-3 exist in erythrocytes and take role in eryptosis [5]. In the same study, it is also reported that erythrocytes expresses FasL. In the line with this and our result, it may be thought that hyperglycemia and oxidative stress direct erythrocytes into hemolytic pathway, very parallel to eryptotic pathway. Then, PS is exposed on the outer membrane of the erythrocyte during hemolysis which results in erythrocyte-to-erythrocyte attachment. Thus, Fas-FasL interaction starts eryptosis, which may protect microcirculation from occlusion and be pointed with caspase-3 positivity, in erythrocytes to escape hemolysis in the process of erythrocyte aggregation. In short, eryptosis may work as a mechanism saving erythrocytes from hemolysis. On the other hand, hyperglycemia and oxidative stress may induce eryptosis independent of hemolysis beginning with death receptor pathway.
It is clearly seen in our study that diabetic rat erythrocytes attached each other and endothelial surface (Figure 1(c)). In reports, increased aggregability was observed in the red blood cells of diabetic patients [8, 9]. In one report, it is shown that PS decreases energy to need erythrocyte-erythrocyte attachment [7]. In addition to these reports, it is claimed that PS exposure is responsible for increased erythrocyte adhesion to endothelium in central retinal vein occlusion [12]. Here, we do not present direct evidence of PS presence on erythrocytes; nonetheless, caspase-3 immunoreactivity may be accepted as indirect evidence of its existence. As a result, we conclude the reason of increased aggregability and adhesiveness may be PS presence in outer membrane of eryptotic erythrocytes. Besides all, it is worthy to say that caspase-3 immunoreactivity is observed in the vascular endothelium of the cerebrum and cerebellum in many areas (unpresented data) in DM group. In line with this, high aggregability and adhesiveness of erythrocytes may cause vascular occlusion which may explain the underlying pathology in microangiopathic complications of diabetes.
Anemia in diabetics is generally overlooked and thought to be developed due to nephropathic complication of diabetes. In addition, low or nonfunctional erythropoietin is accused of anemia [1, 13]. On the other hand, hyperglycemia itself can be the reason of anemia if diabetic treatment is not given properly or absent. As an example, we have seen once a case: 70-year-old female who is diagnosed as having diabetes without nephropathy after hospital admittance is presented with severe anemia (hemoglobin = 8 g/dL) and recovered from anemia (hemoglobin = 12.5 g/dL) with diabetic prescription (unpublished case). We believe that our result, high frequency of eryptotic erythrocytes in diabetics, is a reflection of functional anemia, undetectable with routine laboratory tests, which is also mentioned elsewhere as anemia masked by dehydration [14]. Consequently, to diagnose anemia in diabetics, calculation of intravascular total volume with red blood cell count may be taken into consideration. Alternatively, caspase-3 positive erythrocyte count may be another solution to diagnose functional anemia in diabetics.
5. Conclusions
In short, it is presented here that the number of eryptotic erythrocyte in diabetic rat is higher than non-DM group. This result may help us to understand the bases of anemia and microangiopathy in diabetics. In conclusion, the treatment of masked anemia in diabetes may lead to improvement of diabetic complications in these patients.
Conflict of Interests
All authors fully disclose that there is no financial or ethical conflict of interest.
This project is supported by a grant from Dicle University Scientific Research Project Coordination Unit (DÜBAP), Turkey (10-VF-155). All authors fully disclose that there is no financial or ethical conflict of interest.
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- E. Maellaro, S. Leoncini, D. Moretti et al., "Erythrocyte caspase-3 activation and oxidative imbalance in erythrocytes and in plasma of type 2 diabetic patients," Acta Diabetologica. In press. View at Publisher · View at Google Scholar · View at Scopus
- A. Othmane, M. Bitbol, P. Snabre, and P. Mills, "Influence of altered phospholipid composition of the membrane outer layer on red blood cell aggregation: relation to shape changes and glycocalyx structure," European Biophysics Journal, vol. 18, no. 2, pp. 93–99, 1990. View at Google Scholar · View at Scopus
- M. Martinez, A. Vayá, R. Server, A. Gilsanz, and J. Aznar, "Alterations in erythrocyte aggregability in diabetics: the influence of plasmatic fibrinogen and phospholipids of the red blood cell membrane," Clinical Hemorheology and Microcirculation, vol. 18, no. 4, pp. 253–258, 1998. View at Google Scholar
- N. Babu and M. Singh, "Influence of hyperglycemia on aggregation, deformability and shape parameters of erythrocytes," Clinical Hemorheology and Microcirculation, vol. 31, no. 4, pp. 273–280, 2004. View at Google Scholar · View at Scopus
- H. Ohkawa, N. Ohishi, and K. Yagi, "Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction," Analytical Biochemistry, vol. 95, no. 2, pp. 351–358, 1979. View at Google Scholar · View at Scopus
- J. V. Calderón-Salinas, E. G. Muñoz-Reyes, J. F. Guerrero-Romero et al., "Eryptosis and oxidative damage in type 2 diabetic mellitus patients with chronic kidney disease," Molecular and Cellular Biochemistry, vol. 357, no. 1-2, pp. 171–179, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. P. Wautier, E. Héron, J. Picot, Y. Colin, O. Hermine, and J. L. Wautier, "Red blood cell phosphatidylserine exposure is responsible for increased erythrocyte adhesion to endothelium in central retinal vein occlusion," Journal of Thrombosis and Haemostasis, vol. 9, no. 5, pp. 1049–1055, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. C. Thomas, C. Tsalamandris, R. MacIsaac, and G. Jerums, "Functional erythropoietin deficiency in patients with Type 2 diabetes and anaemia," Diabetic Medicine, vol. 23, no. 5, pp. 502–509, 2006. View at Publisher · View at Google Scholar · View at Scopus
- M. M. Christopher, "Hematologic complications of diabetes mellitus," Veterinary Clinics of North America, vol. 25, no. 3, pp. 625–637, 1995. View at Google Scholar · View at Scopus


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The Tyranny of "Time" – EHR Efficiency Has a Lifecycle
John Lynn is the Founder of the HealthcareScene.com blog network which currently consists of 10 blogs containing over 8000 articles with John having written over 4000 of the articles himself. These EMR and Healthcare IT related articles have been viewed over 16 million times. John also manages Healthcare IT Central and Healthcare IT Today, the leading career Health IT job board and blog. John is co-founder of InfluentialNetworks.com and Physia.com. John is highly involved in social media, and in addition to his blogs can also be found on Twitter: @techguy and @ehrandhit and LinkedIn.
I love when you can find a picture, chart or graph that describes an important concept. I saw that during a CHIME Fall Forum focus group that was led by Heather Haugen from The Breakaway Group. During the focus group, Heather put up the following slide to describe the level of optimization a hospital experiences during the lifecycle of an EHR.
The key element in the above graph is the trough that happens after the initial adoption. I think the slide into that trough of EHR inefficiency is as steep as what's shown on the graph, but the dip in efficiency definitely occurs. In fact, I think that the path to inefficient EHR use is slow and that's why many healthcare leaders don't notice when it happens.
The solution to this problem is to create a program in your organization that manages upgrades, provides ongoing training, and regular workflow assessment and optimization. I imagine most organizations weren't worried about this when they slapped in their EHR to meet meaningful use. However, now they're all going to have to take a deep look into solving this long term problem.
Full Disclosure: The Breakaway Group is a sponsor of the Breakaway Thinking series of blog posts on EMR and HIPAA.


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Enjoy your Blu-ray movies on the road
Play your Blu-ray movies in car! The Philips PB9011 featuring two 9" TFT LCD display screens let you indulge in enjoying your Blu-ray, DVD movies, music and photos on the road. Install and mount easily for in-car enjoyment. See all benefits
Unfortunately this product is no longer available
Enjoy your Blu-ray movies on the road
Play your Blu-ray movies in car! The Philips PB9011 featuring two 9" TFT LCD display screens let you indulge in enjoying your Blu-ray, DVD movies, music and photos on the road. Install and mount easily for in-car enjoyment. See all benefits
Unfortunately this product is no longer available
The stereo speaks provide quality sound and allow you to listen freely. Enjoy music anytime, anywhere, with built-in stereo speakers that allow the convenience and enjoyment of music playback simply by unplugging the headphone.
It comes with convenient in-car accessories to enhance your movie enjoyment on the road. A car adaptor allows you to power your portable DVD player using the cigarette charger, while a mounting strap allows you to attach the player to your car headrest for passenger viewing. Setting up a portable player has never been easier.
The Philips Portable DVD player is compatible with most DVD and CD discs available in the market. DVD, DVD+/-R, DVD+/-RW, (S)VCD, and CD – all of them can play on the DVD player. DVD+/-R is a shorthand term for a DVD drive that can accept both of the common recordable DVD formats. Likewise, DVD+/-RW handles both common rewritable disc types.
Dual screens allow you to display same videos or images from the portable DVD players. Simply plug in and mount the screens on the headrests in your car. Now you can enjoy your favorite DVD movies and JPEG photos with family and friends at the backseats easily and comfortably.
The high resolution (800 x 480 pixel) color LCD display brings images to life, showing off your treasured photos, favorite movies and music with the same 'real life' rich detail and vibrant colors as high quality prints.
Blu-ray Discs have the capacity to carry high definition data, along with pictures in the 1920 x 1080 resolution that defines full high definition images. Scenes come to life as details leap at you, movements smoothen and images turn crystal clear. Blu-ray also delivers uncompressed surround sound - so your audio experience becomes unbelievably real. The high storage capacity of Blu-ray Discs also allow a host of interactive possibilities to be built in. Seamless navigation during playback and other exciting features like pop-up menus bring a whole new dimension to home entertainment.
The Universal Serial Bus or USB is a protocol standard that is conveniently used to link PCs, peripherals and consumer electronic equuipment. Hi-Speed USB devices have a data transfer rate of up to 480 Mbps - up from the 12 Mbps in original USB ones. With Hi-Speed USB 2.0 Link, all you have to do is plug in your USB device, select the movie, music or photo and play away.
The travel bag offers complete protection whilst on-the-go.
The single cable connection design means there is just one cable needed to connect the two Philips Portable DVD players together. No additional cables are needed, there is no mess created and installation takes a few seconds.
With DivX® support, you are able to enjoy DivX encoded videos and movies from the Internet, including purchased Hollywood films. The DivX media format is an MPEG-4 based video compression technology that enables you to save large files like movies, trailers and music videos on media like CD-R/RW and DVD recordable discs, USB storage and other memory cards for playback on your DivX Certified® Philips device.


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The replacement of missing elements of an image, or decorative surface, is often referred to as image re-integration. The conference was a cross disciplinary meeting to investigate the range of approaches taken by different conservation disciplines to image re-integration issues.Brown, A. Jean E. is the author of 'The Postprints of the Image Re-integration Conference 15th-17th September 2003', published 2007 under ISBN 9781904794233 and ISBN 1904794238.[read more]
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With the development LED technology, COB(Chip on board) light source is becoming more and more popular and stands for the future trend of lighting. Hetec, which specialized in COB LED lighting, has developed several generations of COB LED street light. And this is the our latest product.
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Product Code : HTC02
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text: SimiCart Ultimate version is an advanced solution for fast growing business. With Ultimate, merchants can satisfy more customers with famous payment gateways, elegant app layouts and target more loyal customers with reward points. Customers will be impressed by a fast checkout process with address auto fill and free checkout management. This package also benefits merchants with app analytics & perfomance tracking and free installation service.


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When Jason Plott's Western Caribbean cruise was delayed because of dense fog in Galveston, Texas earlier this year, Carnival offered two possible resolutions before casting off: Either a full refund or an abridged cruise, which included an onboard credit and a discount off a future vacation.
Plott didn't like either choice.
"It wasn't enough," says Plott, a director at a Lubbock, Texas software firm. His family couldn't return home early without incurring an airline change fee. And the shortened cruise skipped their favorite ports of call and the offer meant that they'd have to take another Carnival cruise -- something they were reluctant to do.


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Tuesday, June 2, 2009
New Cricut Promo with Stand & Salute & Simply Sweet!
I have spent hours playing with Stand & Salute and it is an amazing cartridge! I just finished a card, which I'll be making a video for, and worked on a mini-album you will also see later today...yikes! It's almost 2 am here. Whoops! Too much cricuting! I better get some rest so I can get all the latest posted in the morning!
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Have you been to Melmoth in KwaZulu Natal? Let us know how you enjoyed your visit to the Zululand region and what you thought of the attractions, restaurants and accommodation options in Melmoth.
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September 2012
Melmoth is historically fascinating and we spent hours exploring the battle field and learning more about the country's history. It is also naturally beautiful. There are not huge malls or entertainment complexes, which suited us just fine but may not be as enticing to other travellers.
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Last month's scuttling of the 30-year US Treasury bond by the US Treasury Department touched millions of Americans, many of them indirectly.
The main effects were to help nudge interest rates lower on big-ticket items such as mortgages and cars, and make intermediate-term bonds (such as the 10-year bond) more attractive to investors.
Few individuals actually hold 30-year bonds, although many own them within their mutual-fund portfolios. The 30-year bond - dubbed the "long-bond" in investment circles - was mainly sought out by institutional investors, such as banks and pension funds.
First issued in 1977, the US Treasury sold over $600 billion worth of the products. By ending the bond, however, Uncle Sam reduces its borrowing costs, while putting downward pressure on long-term rates. (Short-term rates have also been coming down, the direct result of rate cuts by the Federal Reserve.)
Lower rates, of course, add up to good news for consumers. The result, however, is not as sanguine for investors as yields head south.
Still, Treasury issues remain attractive for many mutual-fund investors, says Scott Berry, who tracks bond products for financial information firm Morningstar Inc. While mutual funds based solely on US Treasuries now offer low yields - about 3 percent or less on US government money-market funds, for example - funds that buy different combinations of government products such as agency issues have returned well above 5 percent.
An agency-based fund category Mr. Berry likes is Ginnie Mae (GNMA) funds, which typically yield 0.5 percent to 1 percent more than Treasury bond funds.
Perhaps not surprising, since Sept. 11, investors have poured their dollars into US government bond products - representing a "flight to safety." But the large infusion has pushed yields down - to under 3 percent, for example, on 2-year Treasury notes.
Since they are backed by Uncle Sam, government bond funds don't carry the risk that the bond issuer will default. But they still face the risk of fluctuating interest rates.
Even with lower rates, bond holders can often come out ahead or equal with corporate bonds, since interest payments on Treasury issues are generally exempt from state and local taxes.
Those looking to buy government issues can purchase them through mutual funds or from the Treasury through the "Treasury Direct" program (www.publicdebt.treas.gov).


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Namco Bandai have released a large batch of screenshots for One Piece: Pirate Warriors 2, featuring the entire Straw Hat crew and Eneru.
N4G is a community of gamers posting and discussing the latest game news. It's part of NewsBoiler, a network of social news sites covering today's pop culture.


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Moving one step closer toward a make-over of downtown Culver City, a group of residents and city planners presented their vision for a revitalized city center to the city's Redevelopment Agency last week.
Their suggestions included simplifying travel on the "X"-intersection formed by Culver and Washington boulevards, creating a farmers market and town square, and embedding medallions commemorating famous films in a recessed, tree-lined sidewalk dotted with outdoor eateries.
The suggestions grew out of a weekend workshop in May, during which about 125 people fanned out through downtown Culver City. Their notes and observations led to a report that will be used by city planners as a guide to creating a master plan for the area.
The City Council has already asked staff to study what it would take to implement some of the suggestions contained in the report, Councilman Steven Gourley said. A few projects, such as realigning Culver and Washington boulevards, should begin within a year.


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The Licensed Practical Nurse (LPN), under the supervision of the Registered Nurse, is responsible for administering direct patient care, treatments as ordered by the physician, and administering medications under the proper scope of licensure. This position requires the full understanding and active participation in fulfilling the Mission of CHRISTUS Health Coushatta Hospital, and demonstrating behavior consistent with the Core Values.
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text: We know that the beginning stages of a police state exist in the United States when: a leader is brought into power through illegal means a national catastrophe is used as the pretext to begin a war and institute extraordinary restrictions on constitutional liberties citizen dissent is held to be treasonous the constitutional separation of powers is abrogated by a power-mad executive branch which controls or intimidates the other two branches of government The US Patriot Act was enacted by a Congress that had not actually read it. The only thing representatives and senators got was a two or three page compendium from the White House press office. Nobody was actually given the time to read the provisions of the act. The White House intimidated members of Congress into passing the bill by telling them that if they refused to sign it, they'd be labeled as "unpatriotic"--something almost all members of Congress were frightened of at the time. Lieberman, Daschle and Gephardt later wrote a memorandum stating that Congress had effectively given the Bush Administration "near dictatorial powers." Let the sheeple awake from their daze! Editorial Digest Keeping you informed!


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Nimboxx: Hyper-Converged Infrastructure Developer Exits Stealth
CEO: Rocky Bullock
Hyper-converged infrastructure developer Nimboxx in June exited stealth mode recently with $12 million in new funding and the release of its first appliance, combining storage, server, networking and virtualization technology.
Nimboxx, founded in 2012, targets midmarket MSPs with its 1U appliance containing a mix of flash and disk storage, and can generate 180,000 IOPS of performance. It is based on the Nimboxx Mesh Operating System, the company's software stack that includes server, storage, networking, security and virtualization hypervisor technology and installs on commodity server hardware. Customers can deploy a single unit, or scale both capacity and performance by clustering multiple nodes.


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With "Mark di Suvero at Crissy Field" soon disappearing in our rearview mirror (the successful exhibition closes May 26), the Conservancy is revving up an exciting new attraction on the grassy meadow at the west end of Crissy Field.
In the coming months, the eight steel sculptures that have graced the Crissy airfield will be replaced by a temporary racetrack, as part of our nascent "KART in the Parks" initiative.
Just as the di Suvero exhibit brought art lovers to the Golden Gate National Parks, this project is aimed at connecting the parklands with new communities—namely, local NASCAR enthusiasts and people from around the world who enjoy riding around San Francisco in tiny cars that sound like buzz-saws.
The project also serves as a living, breathing, exhaust-spewing interpretive exhibit, harkening back to Crissy Field's place in the earliest days of auto racing. Indeed, the meadow owes its very existence to the 1915 Panama-Pacific International Exposition and the American Grand Prize auto race that was held during that "world fair." Beginning in 1912, over 360,000 yards of mud and sand were dredged up from the Bay to fill in the swampy wetland along the Presidio waterfront.
The landfill created expansive exposition grounds, site of spectacular pavilions on the east side (including the Palace of Fine Arts) and, on the west, a Grand Prix race track—one mile in circumference, with grandstands for 25,900 people.
There were actually two big races in 1915. The American Grand Prize was held on February 27, a sodden day that saw 11 of the 30 drivers who started the race withdraw because of rain. The event—which featured Eddie Rickenbacker, destined for greatness as America's preeminent flying ace in World War I—was won by dashing Brit Dario Resta, at the wheel of a Peugeot.
Incidentally, Resta also won the Vanderbilt Cup race, held on roughly the same course on March 6—a brighter day that brought out luminaries such as San Francisco Mayor James "Sunny Jim" Rolph and California Governor Hiram Johnson. Resta's average speed on a fast track? A blistering 66 miles per hour.
While the new temporary racetrack will respect and showcase Crissy Field's racing legacy, more modern flourishes will abound. The track surface will be composed of recycled and repurposed materials, and the go-karts will be fueled by biodiesel produced from sustainably sourced soybean oil, collected by Food for the Parks concessionaires.
The karts themselves are crafted of a light but durable plastic/paper composite, with no less than 30% of the fiber derived from back issues of the printed Park Adventures brochure.
Now, if you've read this far with credulity, congratulations! You've taken the checkered flag. But realize, too, that we're having the last lap—er, laugh. Happy April Fool's! (None of the above is true, save for the historical sections about the 1915 races; for more on the evolution of Crissy Field, consult Stephen A. Haller's excellent The Last Word in Airfields.)
Return to Park E-ventures archive or read more articles about related:


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For children ages 2½ - 3½ with caregiver.
Engage your little one in a variety of new ways that stimulate the development of early literacy skills: books, flannel boards, songs, stories and much more. This free program lasts about 30 minutes and registration is not required.
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Program length is 30 minutes.
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Tuesdays at 11 am
Session1: September 4 - October 10
Session2: November 6 - December 12


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Product Description
The Octagonal Plates feature a lovely beaded edge.
Microwave, Dishwasher & Oven Safe.
Available in 10"
Souleo Provence Pottery is the quintessential handmade artisan ceramic tableware evoking Provence. Made by the same family since the 19th century, Souleo Provence Pottery is now being produced in Aledo, Spain. Continuing the Provencal tradition, each piece of Souleo Provence Pottery is glazed then hand-painted with the vibrant colors found in The South of France.
Souleo Provence Pottery is rustic, handmade, hand-painted pottery, therefore imperfections and color variations will occur. These beauty marks are part of the charm of these products. In addition, crackling may be found in the glaze of some pieces. This is due to the firing process and is part of the attractiveness of the pottery.
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So how do you identify what will motivate each of your children to do the best in everything they do? You will first require listening and get to know your child. That means spending time with them and getting to know their likes and dislikes.
Talk to them and learn their specific needs. One of the hardest roles in parenting is motivating your child. Each child is independent and even twins can't always be motivated in the similar way.
Once you've learned what motivates your children to do things on their own, to motivate each of your children, you can expand on that and find individual ways. Motivation requirements will change, as they grow older, mature, and they will need various motivations.
Be a Best Motivator of your children
Try a change of direction with your children. Praise them for the little things and they will begin to see that behaving and getting good grades in school is something worth working for. Only you know what the best goal is to act as a motivator for your children.
Positive motivations work much better than threats and punishment. Those sometimes work in the opposite way and end making matters worse. Most people react to positive reinforcement and praise than they do negative criticism and harshness.
Make Sweet your Child's Tooth
If they have a sweet tooth, it's possible to buy sugar-free candies and even sugar free chocolate. A great motivator I found with my grandchildren is a promise of a Popsicle after toys are picked up. I make the Popsicles myself out of real fruit juice so they are getting a treat and something healthy.
Two for one, not bad is it? Motivation for good behavior can be many different goals, when children are small. One child can be motivated to be on his best behavior by simply giving him a snack as a gift for being good.
As they grow a little older, a sucker or Popsicle won't do the trick any more. They need something they are more interested in. Some may respond to a goal of being able to spend an extra half hour watching TV or playing videos.
Others may be motivated by extra playtime, or increased phone use. You will know what your kids will act in response to by listening to them and tuning into their feelings. How about an extra trip to the library, or a good children's museum, these are magnificent goals to work for.
Make it a fun time and strengthen the positive feelings that come from happy family outings. Never take too lightly how important it is to your child to spend quality time. In keeping your child motivated to grow into the person you want him or her to be, quality, happy time, is valuable.
Goals Change with Maturity
Of course, when they reach the teenage years, you have a new ball game. With the maturity of the teen, goals change. Goals or motivations sometimes have to change daily. If your son's passion is driving, then an enduring goal of earning his own car could be just the ticket to keeping his grades up and staying out of trouble.
Just like schools use their sports programs to keep participants studying and doing what is right, so can any parent do the similar thing. Do you have a child that has artistic talent? A trip to the local artists supply store is the perfect goal for them.
Grandma's House
Maybe the one motivational goal you can give your children is time with them. My grandchildren are small, but their goal is to be the one who was good for the week so they can be present at Grandma's house to spend the night. It has gotten the kids through trial days at preschool, shots for school physicals, and stays at the hospital.
Each child has their own unusual activity that they do with Grandma and they know they will have Grandma's attention the whole time they are here. That's not spoiling them, it is spending time to, really get to know them and what makes them want to perform and do good things.
If you know your child has a special interest, then you can promote that interest into positive reinforcement goals.


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May 27, 2013
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Use coupon code vaporfrombaker to take 10% off your total order (works on hardware too).
Author: vapor
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Records, CDs, Songbooks and more!
Odd Artwork and graphics for sale from local and legendary artist.
You Love gals! This section if full of em. NSFW warning.
Don't go without pants!
We would not be complete without exploring and exploiting the bizarre, the strange, the odd and the deformed.
Strange curiosities you can own.
HEY THERE BROTHERRRRRRR! Wrasslin' and Wrestling items signed, unsigned, rare and hard to find. From Books to toys to paper emphemera.
Comics and Zines from the underground. Some rare and hard to find!
Kustom Kulture & Hotrod items for the real car lovers.
Tattooers and Tattoo Artis History
Items that may have clues.
Some of the best forms of entertainment. Books!
The Best Collection of Vintage Posters in Philadelphia.
We're not your local Toys R'Us.
We searched the world for odd things so you did not have to. Check out the Antiques and Vintage items we come across and are now selling to you!
Tiki Mania! Have a BBQ! Or Decorate your house!
Items for, from, and about Philadelphia and the region close.


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The Grand Canyon (Courtesy of Wikimedia Commons)
This article originally appeared at TomDispatch.com. To stay on top of important articles like these, sign up to receive the latest updates from TomDispatch.com.
Several miles from Phantom Ranch, Grand Canyon, Arizona, April 2013—Down here, at the bottom of the continent's most spectacular canyon, the Colorado River growls past our sandy beach in a wet monotone. Our group of twenty-four is one week into a 225-mile, eighteen-day voyage on inflatable rafts from Lees Ferry to Diamond Creek. We settle in for the night. Above us, the canyon walls part like a pair of maloccluded jaws, and moonlight streams between them, bright enough to read by.
One remarkable feature of the modern Colorado, the great whitewater rollercoaster that carved the Grand Canyon, is that it is a tidal river. Before heading for our sleeping bags, we need to retie our six boats to allow for the ebb.
These days, the tides of the Colorado are not lunar but Phoenician. Yes, I'm talking about Phoenix, Arizona. On this April night, when the air conditioners in America's least sustainable city merely hum, Glen Canyon Dam, immediately upstream from the canyon, will run about 6,500 cubic feet of water through its turbines every second.
Tomorrow, as the sun begins its daily broiling of Phoenix, Scottsdale, Mesa, Tempe and the rest of central Arizona, the engineers at Glen Canyon will crank the dam's maw wider until it sucks down 11,000 cubic feet per second (cfs). That boost in flow will enable its hydroelectric generators to deliver "peaking power" to several million air conditioners and cooling plants in Phoenix's Valley of the Sun. And the flow of the river will therefore nearly double.
It takes time for these dam-controlled tidal pulses to travel downstream. Where we are now, just above Zoroaster Rapid, the river is roughly in phase with the dam: low at night, high in the daytime. Head a few days down the river and it will be the reverse.
By mid-summer, temperatures in Phoenix will routinely soar above 110°F, and power demands will rise to monstrous heights, day and night. The dam will respond: 10,000 cfs will gush through the generators by the light of the moon, 18,000 while an implacable sun rules the sky.
Such are the cycles—driven by heat, comfort and human necessity—of the river at the bottom of the continent's grandest canyon.
The crucial question for Phoenix, for the Colorado and for the greater part of the American West is this: How long will the water hold out?
Major Powell's Main Point
Every trip down the river—and there are more than 1,000 like ours yearly—partly reenacts the legendary descent of the Colorado by the one-armed explorer and Civil War veteran John Wesley Powell. The Major, as he preferred to be known, plunged into the Great Unknown with ten companions in 1869. They started out in four boats from Green River, Wyoming, but one of the men walked out early after nearly drowning in the stretch of whitewater that Powell named Disaster Falls, and three died in the desert after the expedition fractured in its final miles. That left Powell and six others to reach the Mormon settlements on the Virgin River in the vicinity of present-day Las Vegas, Nevada.


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Posts filed under 'video'
Invitation to become a bot herder
What else would you call it? Consider the facts:
– Owen Walker, aka AKILL, the Kiwi bot herder who was stupid enough to get caught, couldn't stop smiling in court when the judge called him a "very bright young man."
– He spent over two years building bot nets- not a person who was a mule but someone who actively recruited people for his A Team- and would have kept going if not stopped. The judge still sees no criminal intent on his part, just curiosity.
– Even the prosecution called for leniency. So much for the vaunted FBI operation Bot Roast.
– He controlled 1.3 million computers around the world yet escaped conviction (also video) since it might ruin the prospects of using his skills in a positive way. No doubt those 1.3 million people are thrilled at that prospect as is UPenn, which he crashed for a couple of days with an accidental distributed denial of service attack
– All he got was a fine of $9,526 or about US$ 7,300 for damage that runs into millions of dollars because all the police actually proved was the UPenn attack.
OK, so he was 16 when he started and suffers from mild Asperger's syndrome but what message does the sentence send to bored teenagers? That the Internet is a lawless wild west? That if you're stupid enough to get caught, don't worry, there's not going to be a hanging? Instead, the police and overseas companies will line up to give you a job? That all you're going to get is a fine that you can probably pay from your first month's salary (as you've already blown the $40,000 you've made)?
From the news coverage, it seems to me that all of the hinting that he might work for the police is just a red herring.
Owen Walker was not that good a programmer, even though the police think so (video), just a person with a very relaxed sense of right and wrong.
The message is physical crime is not worth it- you actually do get sent to jail and no prosecutor is going to ask a judge to discharge you without a conviction. The Internet is where the smart guys go to- it seems that everyone is on your side then.
On TV (video) they aren't willing to speak out against the sentence. So what's next? A book deal? An invitation to speak at the RSA Conference a la Frank Abagnale?
Do we get the crime that we deserve?
NZ: Identity Month
In my first official post on the SSC blog, I mentioned that April is Identity Month, a time for NZ government agencies to talk about identity management.
The first event of the month was yesterday when the Biometrics Institute organised its 2008 Annual New Zealand Conference. I co-presented with a colleague about igovt and then was on the "Biometric Data Management and Data Security Issues" panel. The panel discussion gave me an opportunity to talk about the dangers of using static identifiers like biometrics and gave the example of Germany's unfortunate interior minister.
The highlight of the month is the Identity Conference on 29th and 30th April but there are two more events around the same time that are worth having a look at:
First, a barcamp focussing on User-Centric Identity on 25th and 26th April. Secondly, the Office of the Privacy Commissioner's next Technology and Privacy Forum has Marek Kuziel on 28th April talking about "OpenID Enabled New Zealand."
With so much happening, it's heaven for the identityrati in Wellington. And, with apologies to the people across the ditch, where the bloody hell are you?
[To be fair, I actually did like the original advert and found the politically-incorrect NZ spoof only somewhat amusing.]
Interviewing Simon Willison about OpenID
During the recent Webstock conference, I had the opportunity to interview Simon Willison about OpenID. This is now available online (windows streaming video, MP3, about 15 minutes).
I found talking with Simon really interesting, whether it was about Webstock, New Zealand, or OpenID. He had some great insights into the current state of play, including the challenges and opportunities facing OpenID. I particularly liked his emphasis on looking at OpenID in the context of decentralised social networking and the fit with OAuth and OpenSocial.
Though, I did think Simon did well to duck the question about national-level implementation of OpenID (a la Estonia).
As a first go at video interviewing, it was certainly a great experience for me. But I'm clearly no John Campbell so I guess I'll have to keep my day job…
Webstock recordings now available
The Easter Bunny has done his magic and recordings from last month's Webstock conference are now online. There's hours of great quality presentations to sit back and enjoy.
I had earlier posted comments on day 1 and day 2.
For Kiwis, my pick is the interview ("fireside chat") of TradeMe's Sam Morgan (streaming video, mp3). For the identityrati there is Simon Willison on OpenID and decentralised social networks (streaming video, mp3).
Very cool stuff.
Google's data itch
Google is a data-driven company. That's kind of obvious when you think about it but just how true that is was made clearer in a blog post by Google's Chief Economist, Hal Varian, Why data matters. The first sentence of the post sets the tone, "Better data makes for better science."
He provides a history of search to come up with some critical points, "But in order to come up with new ranking techniques and evaluate if users find them useful, we have to store and analyze search logs… If we don't keep a history, we have no good way to evaluate our progress and make improvements… the data in our search logs will certainly be a critical component of future breakthroughs."
Just what information does Google track? They've got three videos and a whole sub-site that explains things.
It has information people mostly never read like "We may combine personal information collected from you with information from other Google services or third parties to provide a better user experience…" as well as "our servers automatically record the page requests made when users visit our sites. These "server logs" typically include your web request, Internet Protocol address, browser type, browser language, the date and time of your request and one or more cookies that may uniquely identify your browser."
What they are not as explicit about is that cookies are set to typically expire in 2038 or that they have never erased a single search query (which, when you consider that about 60% of all web searches are Google, is a staggering amount). And, just like other companies, they will hand over the data to governments when lawfully required to do so.
Google is a company who has as one of their ten key philosophies "You can make money without doing evil." Making money is of course not evil but some underhand tactics like automatic matching, broad matching, content networks, the way the toolbar operates, etc. come pretty close.
As a data-driven company, I think it is likely that several corollaries arise that tends to explain some of the things Google does:
Corollary 1: Data is valuable therefore the more the better. So, Google collects and stores data about everything at everytime about everyone. Searches are just one of the many, many collection points across its vast reach.
Corollary 2: The richer the data the better. Context and results are important to give better insight so the more the linked data it can get, the more it can learn from the data. Hence, the combination of personal information from multiple services.
Corollary 3: Data is a competitive advantage. Not only does Google need it for improving search but as a core corporate asset that drives advertising revenues.
Corollary 4: Collection of data has to be protected at all costs. Hence, Google's disingenuous arguments about how IP addresses aren't personal information (PII).
There's a whole lot more but it looks like data is Google's itch and the more it scratches, the more privacy advocates feel the pain.
Aussie for privacy
New York governor Eliot Spitzer might have saved himself a whole lot of trouble if he was instead an Australian ministerial staffer.
The Australian Government has ordered over 315 staff to fill out a 25-page form and undergo an in-depth interview about their personal finances, drug habits and sexual history to get security clearance. The reason? To protect them from blackmail.
In what is perhaps the understatement of the year, Cabinet Secretary John Faulkner said that "Some staff find it intrusive."
Gaining security clearance includes requiring staff to list their history of sexual partners, reveal extra-marital affairs and detail homosexual experiences.
Privacy advocates like Roger Clarke point out that "It's a given that sensitive data, stored in large databases will inevitably leak."
With apologies to Foster's (see this iconic commercial if you're not familiar about this reference), is this Australian for privacy?
NZ: Privacy review report
It seems to be the season for official privacy reviews. The Australian Law Reform Commission recently published its recommendations to reform Australia's privacy laws and the UK Information Commissioner's Office has launched the UK's first Privacy Impact Assessment (PIA) handbook.
Joining the list, in NZ the Law Commission has released a study paper Privacy: Concepts and Issues which is the first stage in a major review of laws related to privacy. There is also a video of the press conference of the report's launch (23 minutes) that includes a good overview of the paper and a discussion on the interplay between privacy and technology.
The report is the outcome of stage 1 of the Law Commission's Review of Privacy, and provides background for the later stages. It therefore does not include recommendations.
As one would expect, one of the big questions it looked at was "How is changing technology (particularly the internet) affecting privacy?" Other questions looked at include:
• What is privacy?
• How has it been recognised and protected by the law?
• Are there particular Māori concepts of privacy?
• Do young people have different ideas about privacy from older people?
Given the report's importance, scope, and size (222 pages) it is hard to summarise it or highlight only a few things. I will come back to the report in future blog posts and look at how some of the major questions have been addressed.
However, one thing that I would like to highlight is the recognition of the work we are doing in the Authentication Programme. The report says:
"In New Zealand, innovative work on authentication is being undertaken as part of the e-government programme coordinated by the State Services Commission… New Zealand may not be a leading developer of new hardware or software, but our relatively small size may assist in finding innovative ways of protecting privacy in the design of systems, as the example of the e-government programme suggests."


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Bull Walrus
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Urban areas are already experiencing impacts of a changing climate including increased temperatures, flooding, and extreme storms. These impacts are projected to increase in frequency and magnitude over the next century, leading many cities to develop plans to adapt and prepare for these challenges. Agriculture and forestry sectors can both work to address these changes in an urban environment.
Urban agriculture helps to address local food insecurity issues in cities and suburban areas. Growing food in cities can take the form of backyard, roof-top and balcony gardening, community gardening in vacant lots and parks (sometimes spanning several city blocks), roadside urban fringe agriculture, livestock grazing in open space and intensive indoor hydroponic or aquaculture facilities. Urban agriculture eases access to food, reconnects communities to the practice of growing food, and engages the community on a variety of levels. Increasing tree canopy is often considered in urban climate change adaptation plans, where trees can help reduce local heat island effects, control storm water, and improve air quality. Although urban trees can be an important part of adaptation solutions, they also can be vulnerable to the impacts of climate change. These urban trees may be experiencing stress from improper planting, restricted rooting conditions, road salt, and air pollution already, and therefore extremely vulnerable to climate change.


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Warning... There are a lot of pictures in this post!
Thanks to me! (Prayer)
I can't believe there is only a week and a day left till Christmas!
I basically spent all morning outside. We played hide-and-seek. Then we played
capture the flag. It didn't work very well. The forts with the flags in them were impenetrable.
We had fun until lunch. Then it was time for Jed and Ella's friends to go home. Mom was meeting their Mom halfway to our house. After Mom dropped the kids off, Charity, Elijah, Jed, and Ella had a newspaper route. They earned $39 in tips!!! I was shocked. They were also given a box of chocolates.
Later on...me and Eve were playing Lego in the boys' room. We then heard Mom tell everyone to go upstairs for the advent! In the middle of the afternoon! Okay, it was like 4:30, but still! Normally we do the advent at night! We went to search, sadly with no hints from Dad. Elijah found it.
His smile looks so fake it drives me crazy! :)
While I was taking this picture I noticed that under our tree was getting really full, and I thought I would share...
Notice the matching wrapping paper! We managed to get all our gifts so far in the same wrapping paper! Anyway, here's the card...
You got it! Breakfast for dinner! That's why we had to do the advent before dinner, because it was dinner! Mom got started right away. Charity and Eve helped. I took pictures and watched Addy.
The menu was...
This soon turned into...
(Notice the steam?)
After pancakes there was scrambled Eggs...
Addy wanted to pose and say, "Cheese!" for me so I took her picture...
Sorry about the background...:}
We also had toast.
Now for the Barbie on the shelf. Yes, we didn't do it until dinner time, but at least we didn't forget! right?
Barbie decided to make chocolate milk for Ella and Lily to have with their breakfast/dinner.
(She made some for herself as well..)
Barbie ate at our table tonight!
Their chocolate milk...
And their pancakes...
Mom made them "E" and "L" pancakes.
Lily said they were awesome!
That about sums up our 8th advent! I hope you enjoyed my post!
Merry week-before Christmas!