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Supreme Court Justice Sonia Sotomayor granted a last-ditch plea from Catholic groups Tuesday night to block a birth control mandate in the new health care law for religious organizations, just hours before it was to have gone into effect. The … Continued
Monthly Archives: December 2013
Goalposts, Moved: Climate Buffoons Now Say Earth Will Warm Four Degrees By 2100 or Something
Considering all the prior predictions have missed the mark, let's just move this one up 86 years. By then maybe they'll free the idiots from the Antarctic ice. Temperatures are on course to rise at least 4 degrees by the … Continued
Krauthammer's Take: Other than Obamacare, Biggest 2013 Story is Rising Libertarianism
Obama pollster: reporters should stop covering polls in 2014
U.S. Asks for Release of Terror Supporter Lynne Stewart on 'Compassionate' Grounds; Update: Released
The terrorists she aided and abetted never showed much compassion. Not to mention her total lack of remorse for aiding them. The U.S. government has asked a New York judge to release a dying former civil rights lawyer who was … Continued
Of Course: Up to 73% of Convicts Register as Democrats
Color us shocked. A new study of how criminals vote found that most convicts register Democratic, a key reason in why liberal lawmakers and governors are eager for them to get back into the voting booth after their release. "Democrats … Continued
Obama celebrates New Year's Eve with fundraising demand
Humiliated Climate Clowns to be Rescued From Antarctic Ice by Helicopter
So because of their vanity we now will witness helicopters coming to the rescue of these buffoons. They should be forced to pay all costs involved for this farce. Passengers on board a research ship that has been trapped in … Continued
Ten Forms of 2013 Media Malpractice
MSNBC's Harris-Perry Apologizes to Romney Family
NYT: 'We had a reporter on the scene talking to the attackers during the [Benghazi] attack'
Democrat Imbecile Eleanor Holmes Norton: People Aren't Signing Up for ObamaCare Because They Think It's Been Repealed
Ladies and gentlemen, your Democrat moron of the day. The lower-than-hoped-for enrollment numbers on the federal exchanges are due to Republican efforts to repeal Obamacare, Delegate Eleanor Holmes Norton (D., D.C.) argued on Monday. Norton blamed a "negative propaganda campaign" … Continued
NYC Department of Education Investigator Sent Teacher Penis Pics: "I like it dirty"
Tell us more about this war on women. A Department of Education detective tried to have sex with a Brooklyn teacher he was probing in exchange for letting her keep her job, she charges. Investigator Lawrence Scott, 40, allegedly sent … Continued
Democrat Panic: If We Don't Defeat Boehner's Tea Party 'President Obama's second term agenda is dead in the water'
Boehner's Tea Party? Really? We're nearly out of time — so we won't waste any: If Boehner's Tea Party House holds on to power in 2014, they will do everything in their power to ensure that President Obama's second … Continued
Climate Clowns Trapped in Antarctic Ice: 'Sea ice is disappearing due to climate change, but here ice is building up'
This is too funny for words. A statement from the Australasian Antarctic Expedition: We're stuck in our own experiment. We came to Antarctica to study how one of the biggest icebergs in the world has altered the system by trapping … Continued
Prostitute Says Spitzer Enjoyed Choking Her: "The more struggle there was, the more he was into it"
So let's talk about that Democrat war on women. He socked it to her. Eliot Spitzer lusted after violence, a former hooker says in a new tell-all book — revealing in graphic detail how the love gov pinned her to … Continued
NY Times: Benghazi Attack 'Fueled in Large Part by Anger at an American-Made Video Denigrating Islam'
You cannot be serious. Months of investigation by The New York Times, centered on extensive interviews with Libyans in Benghazi who had direct knowledge of the attack there and its context, turned up no evidence that Al Qaeda or other … Continued
Coercing Conformity: A government that creates the climate for bullying is the worst of the bullies
White House Cravenly Uses de Blasio Daughter's Fight With Depression and Substance Abuse to Promote Obamacare
The Season of Giving: Chicago Man Offered Dismemberment as a 'Present'
A truly heartwarming tale of giving during the holiday season. An 18-year-old man who was asked to move out of the Northwest Side apartment he shared with his aunt and her boyfriend killed the older man with a hammer, then … Continued


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About Us
In Print
Contact Us
December 2013
Losing Faith
December 7, 2013
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I never knew Faith Hedgepeth. I was never graced with her warm smile, nor was I familiar with the optimistic spirit and joy she brought to those who remember
Midwives: Reclaiming Maternal Health Rights
December 6, 2013
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What's the first thing that pops into your mind when you hear the word 'midwife'? For me, it was outdated homebirths and '70s hippie women. With the
Why I'm Tired of Getting a Gold Star for Being a Male Feminist, and Why You Should Be, Too.
December 4, 2013
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When I'm meeting someone for the first time, no matter who they are, this conversation always seems to happen in one of two ways. Both cases always start
In Search of My Mother's Garden
December 1, 2013
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During the spring semester of my junior year, I took four different Women's & Gender Studies classes and all four placed a heavy focus on feminist literature

subset: commoncrawl


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Research suggests that both these drugs are as bad as each other!
No Difference in MS Disease Activity Between Treatments 16 June 2007
Head-to-head comparison of interferon beta-1b (Betaseron, Bayer HealthCare Pharmaceuticals [erstwhile Berlex]) and glatiramer acetate (Copaxone, Teva Pharmaceutical Industries) shows comparable efficacy but continuing multiple sclerosis (MS) disease activity with both agents.
The study, called Betaseron vs Copaxone in MS with Triple-Dose Gadolinium and 3-T MRI Endpoints (BECOME), is the first investigator-initiated, randomised, prospective, rater-blinded trial to directly compare these 2 agents in the treatment of MS. The study was supported in part by a grant from Berlex/Schering AG.
Diego Cadavid, MD, associate professor in the department of neurology and neurosciences, New Jersey Medical School, in Newark, and the Multiple Sclerosis Center at Holy Name Hospital, in Teaneck, New Jersey, reported the findings here during the Whitaker Research Track presentations of the Consortium of Multiple Sclerosis Centers 21st Annual Meeting.
Seventy-five patients with MS were randomly assigned to treatment groups: 36 with interferon beta-1b and 39 with glatiramer acetate. Combined active lesions (CAL) were monitored monthly for 2 years using 3-tesla MRI with triple-dose gadolinium and a 40-minute delay to maximise enhancement. Clinical indications of relapse, cognition, and disability were also monitored. A total of 2754 CALs were identified during the study.
After 15 months of treatment, a similar number of lesions occurred in both treatment groups, but the occurrence of lesions varied considerably between patients. "Approximately half the MRIs in each group showed new lesions and half did not," he said.
Dr. Cadavid then reclassified the 75 patients by CAL pattern: no CALs for 2 years (n=15), episodic CALs (n=44), and frequent CALs (n=16). The occurrence of these patterns in the 2 treatment groups was not significantly different (Χ2, P = .7).
Disease activity continued to some extent in 77% to 83% of the patients, again with no significant difference between the 2 drug therapies.
Sensitive Technique
Michael Racke, MD, chair of the department of neurology of Ohio State University and moderator of this session, focused his comments to Medscape on the unusually sensitive MRI technique. "In terms of clinical applicability, nobody's going to do monthly triple-dose gadolinium 3-tesla MRI. But the real problem is, we don't have a histologic correlate."
"Dr. Cadavid's data do suggest that the 2 drugs compared are very similar," continued Dr. Racke. However, he thinks the unusual MRI technique used in this study is measuring something different than an MRI with, for instance, a 1.5-tesla magnet after single-dose gadolinium. "Basically, since Berlex funded the study, they thought that Betaseron would beat Copaxone — and it didn't. So the issue becomes: Why is that? With a typical MRI, would you have seen what was anticipated? This technique is very sensitive, but we don't know exactly what we're measuring with that increased sensitivity."
CAL Patterns
Dr. Cadavid also analysed the results of the behavioural and cognitive tests for the 3 CAL pattern groups, including the 25-foot walk test, a test of response speed, and the cognitive skills index (CSI). In nearly every test, the group with frequent CALs scored lower than other groups in baseline testing and continued to do more poorly throughout the study.
Talking with Medscape, Dr. Cadavid said he had been very surprised to find that patients in the frequent-CAL group scored more poorly from the beginning of the assessments. As to why their impairment had not been noticed earlier, he commented: "It's a matter of how the relapse presents. If they lost vision in 1 eye, they'd be picked up right away. But if they have a subtle problem with balance, gait, or cognition, they may not be picked up. People tend to assign the symptoms to something else."
Regarding clinical utility of the 3 CAL patterns, Dr. Cadavid emphasised: "You cannot assume that just because you put [patients] on therapy you've got them under control. You have to be careful, especially with the group with frequent lesions, because they seem to already carry some loss of function when you first see them." Based on the results of this study, he added, "Even though you put them on the drug, you are not really controlling them. They're getting disabled in front of you."
The point is, he added, "after 10 or 12 years of these first-level drugs, we are entering a phase of what seem to be more powerful drugs with more serious side effects. We cannot put everybody in the same basket. It's time to become more selective and target the patients with more frequent lesions with what may be more powerful drugs with a higher risk."
Source: Consortium of Multiple Sclerosis Centers 21st Annual Meeting. John Whitaker Research Track. (16/06/07)


text:
Popular Now
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Popular Now
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01803 865913
+44 1803 865913
Series: Aquarium Atlas - English Edition Volume: 1
By: Rüdiger Riehl(Author), Hans A Baensch(Author), Hans A Smith(Translated by), Eberhard Schulze(Translated by), Bob Behme(Translated by)
992 pages, colour photos, b/w illustrations
Language: English
Volume 1 of the Aquarium Atlas contains condensed knowledge in one compact tome. It presents about 600 ornamental fishes, 100 aquatic plants and, beginning with its 11th German edition, a chapter on amphibians and crustacea. It is a self-contained book. At present, the Aquarium Atlas consists of 6 volumes, each containing different species. Approximately 4,750 fishes and 330 aquatic plants have been pictured in full color and described. Scientists from around the world have helped to give the Aquarium Atlas worldwide renown.
The hardback is billed as the sixth revised English edition, 2005 reprint, the paperbak as the sixth revised English edition, 2004 reprint.
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Joseph Christiana
The Nightmare - Horror Short Film
Tormented by one surreal, terrifying predicament after another, a boy is confronted with his inner fear. As the air becomes harder and harder to breath, as his tormentors become stranger and press in closer, the boy begins to realize the true nature of his situation.
An official Fearnet film!
Screenings to date:
Washington DC International Spooky Movie Festival
Newfilmmakers Winter Festival
Sprockets and Splices Cable Television Show
Montreal Underground Film Festival


text:
(Recasts; adds details, share movement)
April 29 (Reuters) - Biotechnology company BioMarin Pharmaceutical Inc (BMRN.O) reported a quarterly profit that beat market estimates, helped by strong sales of two of its enzyme replacement therapies, and raised its full-year revenue outlook.
The company posted first-quarter earnings of $1.7 million, or 2 cents a share, compared with a net loss of $9.3 million, or 10 cents a share, a year earlier.
Revenue surged 165 percent to $60.4 million.
Analysts on average were expecting the company to report a loss of 4 cents a share on revenue of $55.7 million, according to Reuters Estimates.
Sales of its enzyme replacement therapy (ERT) Naglazyme were $27.7 million, up from $18.4 million in the year-ago quarter. Net sales of BioMarin's other ERT, Aldurazyme, rose about 37 percent to $36.8 million .
The company based in Novato, California, said it expects 2008 earnings of $28 million to $40 million, on revenue of $271 million to $316 million.
It had previously expected net income of $20 million to $40 million on revenue of $255 million to $306 million. Analysts were expecting earnings of 41 cents a share, on revenue of $302.6 million for the period.
Shares of the company were trading at $35.00 after the bell. The stock closed at $33.77 Tuesday on Nasdaq. (Reporting by Aradhana Aravindan in Bangalore; Editing by Deepak Kannan)


text: Bachelor Pad Contestants Are "Crazed Sexual Deviants" 705 Emily A. Farris 08/10/10 11:42AM Filed to: Jimmy Kimmel Live Jimmy Kimmel Live Bachelor pad Chris Harrison TV Jimmy Kimmel Video Chris Harrison talked to Jimmy Kimmel last night about how the contestants are extremely good looking but all they have to offer is their sex drive. Apparently this leads them to do things that are probably "illegal in 49 states."[There was a video here]


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John Denver ~ Steve Irwin
Cassandra Denver ~ Terri Irwin
Bindi Irwin has legal issues obtaining her
$360,000 'Dancing With the Stars' salary.
All monies will be withheld from Bindi until a
death certificate for Steve is produced!
Steve "The Crocodile Hunter" Irwin's daughter, Bindi Irwin, said she will indeed get paid her estimated $360,000 in wages from both competing and winning ABC's "Dancing With the Stars."
"We're all good. It's all sorted now," she told TMZ when asked about the status of the minor contract. "Yeah, we're all happy."
In California, a judge must approve contracts made on behalf of a minor. Part of that process can include the parents waiving any rights to the child's salary. In this case, 17-year-old Bindi's mother Terri signed over her rights. But the court said that they failed to have the father sign off his rights, as well. Clearly, that's impossible as Steve died after being stung in the chest by a stingray in 2006.
Bindi Irwin
Nevertheless, Bindi continued to compete on the ABC dancing competition alongside partner Derek Hough. Her base salary was $150,000 with additional pay as she advanced in the competition. The reported total for making it through all 11 weeks is $360,000, according to People Magazine.
TMZ reported no proof of Steve Irwin's death has been provided and the judge has yet to clear Bindi's 'DWTS' contract at this time. TMZ has been told proving her father is dead without producing a death certificate shouldn't be hard for Bindi's attorneys. (Wingfoot just got a BIG whiff of Bullshit... There will be no death certificate for Steve Irwin because the talented actor who played the characters of John Denver and Steve Irwin is still alive. It's all 'Make Believe'.............. just sayin.')
The young activist said when she does get paid, she won't be keeping it.
"Everything I make goes back to wildlife conservation," she told TMZ. "It's wonderful. It's who we are."
Bindi's parents established the nonprofit organization Wildlife Warriors in 2002. "We have conservation projects all over the world," the dancing champ said.


text:
Financial Services
Wireless Carriers
Traditional KBA doesn't stop professional fraudsters
Today, traditional call center security isn't stopping professional fraudsters who are armed with better technology, stolen identities, social engineering skills, and ring coordination. Recent data shows an increasing number of successful attacks, with KBA (knowledge-based authentication) beaten 80% of the time.
Most fraud is repeat calls by the same fraudsters
Professional fraudsters explore a call center's processes, discover weaknesses, then repeatedly attack. Using Victrio, clients can measure the 'repeat fraud rate', the percentage of total fraud calls in a time period by the same callers. Repeat rates are measured to be shockingly high across the industry:
Brokerage fraud: 71%-89% repeat rate
Credit Card fraud: 72%-95% repeat rate
Deposit Account fraud: 42%-76% repeat rate
The Solution»


text:
The LMH0001 SMPTE 259M / 344M Serial Digital Cable Driver is designed for use in SMPTE
259M / 344M serial digital video applications. The LMH0001 drives 75Ω transmission lines (Belden
8281, Belden 1694A or equivalent) at data rates up to 540 Mbps.
The output voltage swing of the LMH0001 is adjustable via a single external
The LMH0001 is powered from a single 3.3V supply. Power consumption is typically 125mW.
The LMH0001 is available in a 16-pin WQFN package.


text:
Fronius Service Partner search
|Fronius Service Partner
|Fronius Service Partner Plus
Your searchresult
Offizieller Fronius Service Partner Plus
Move the map with the mouse or zoom in and out. Click on the contact icon in the selected area and then click on a company name in the speech bubble that appears.
You can search your location or enter your ZIP code in the search fields above the map to display selected Fronius service partners in your area.


text:
The Man Without Fear
This week the panel weighs in on the Seigel Superman case, review Dominion from Boom! Studios, Green Lantern #29 from DC, and Young X-Men #1 from Marvel. Brian recommends a couple of Hulk trades, Stephen makes a major announcement, and the panel takes a look at Frank Miller's run on Daredevil.
Listen to the Show![podcast]http://media.libsyn.com/media/majorspoilers/majorspoilers_08.mp3[/podcast]
A big Thank You goes out to everyone who downloads, subscribes, listens, and supports this show. We really appreciate you taking the time to listen to our ramblings each week. Tell your friends about the podcast, get them to subscribe and, in turn, help the Hero Initiative.
1)Judge awards 50% ownership of Superman to Siegel heirs
2)Secret Invasion arrives this week – Who do YOU trust?
The Major Spoilers Hero Drive
Stephen announced a special pledge drive, where Major Spoilers will donate 50-cents per subscriber to the Hero Initiative.
Bryan reviews Dominion 1-4 (and half of 5) from Boom! Studios
Stephen takes a look at Green Lantern #29 from DC Comics and mentions it has a great connection to last week's Emerald Dawn review.
Rodrigo blasts Young X-Men #1 from Marvel
Bryan follows up and recommends several Hulk trades from Marvel.
Rodrigo's Words
Rodrigo defines the term Canon and the panel discusses how it works or doesn't work in comics.
Question of the Week
Which Batman symbol do you like the most?
a) Bat on Yellow Circle
b) Black bat across chest
c) Batman Begins bat
d) Justice League Unlimited bat
e) Batman Beyond bat
Take the poll!
Frank Miller's Daredevil Omnibus Companion
The panel members were able to land a copy of the Daredevil Omnibus Companion featuring Daredevil stories by Frank Miller including the Daredevil: Man Without Fear.
Contact us at firstname.lastname@example.com
Music from this episode comes from Ookla the Mok. You can visit them on the web at www.ooklathemok.com and purchase their music at the iTunes Music Store.
5 Comments
hey, where's the direct download. i can't find it
dang it, i need it tonight, i'm going away for the week and i might not have an internet access where i'm going
i hate you wordpress 2.5, or should i blame podpress??
aaaaaaaaaaahh, i love you man.
you know what, i was away from comics for a while, and when you re-started the site, my love in comics was renewed. and you made me buy DC the new frontier absolute.. and i don't regret it.
i also suggest absolut kingdom come and absolute watchmen. of course omnibus daredevil is next on my list, as well as omnibus frank miller elektra when it comes out
thanks again


text:
Cover image: A Philippine tarsier (Tarsius syrichta) chews a katydid under dim mesopic light conditions. A paper by Amanda D. Melin et al., in this issue of Proceedings B (http://dx.doi.org/10.1098/rspb.2013.0189), raises the possibility that such conditions favoured the evolution of enlarged eyes and high-acuity trichromatic vision in the last common ancestor of crown tarsiers, a concept that challenges prevailing views on the adaptive origins of anthropoid primates. Photograph by Petr Slavik © used with permission.
See other Royal Society journals
More most read articles
Large datasets are available through Proceedings B's partnership with Dryad


text:
PAKISTAN: Government Refuses Filing of a FIR Against PM
PAKISTAN: Government Refuses to Allow the Filing of a FIR Against Prime Minister And the Chief Minister of Punjab
The government, once again has refused to follow the orders of the Lahore High Court which directed police to register a First Information Report (FIR) which names amongst others, Prime Minister Nawaz Sharif, the Chief Minister of Punjab Mr. Shahbaz Sharif and 19 others including federal and provincial ministers and government personnel as responsible for the killing of 14 persons in a police shooting on a peaceful protest.
Earlier, the Sessions Court in Lahore had ordered police to register the First Information Report which names 21 federal and provincial authorities including Prime Minister Nawaz Sharif and Punjab Chief Minister Shahbaz Sharif as responsible for the incident on 17th June 2014 where police blindly fired at protesters of Minhajul Quran killing 14 persons on the spot including two women. 85 persons including women and children received bullet wounds following this shooting. Following the police shooting frenzy, when family members of those killed and had attempted to file First Information Report (FIR) calling for an investigation into the shooting and naming those responsible, police have flatly refused to file the FIR. The refusal prompted, the leader of the protest, Minhajul Quran to file a case in the sessions' court to allow the victims of the shooting to file the FIR with the police – to which the sessions court agreed and made order to the affect that the families of the victims be allowed to file the FIR.
However, four federal misters; Pervaiz Rasheed - Minister of Information; Khawaja Asif – Minister of Defence, Khawaja Saad Rafique - Railways Minister and Abid Sher Ali - Minister of State for Water and Power challenged the order of the sessions' court in the Lahore High Court. The Lahore High Court turned down the petitions and restored the decision of sessions' court for filing the FIR from the victims.
In the meantime, on August 26, a report of the Judicial Commission – that was appointed to investigate the shooting incident - was made public through the media by 'unnamed sources'. The government conspicuously kept the report secret for 17 days. The Commission report has held the government responsible for the killings of 14 persons and stated that in the aftermath of the incident police acted on government's orders. The Punjab provincial government has not denied the public of the contents of the report but says instead that the report was received and was being examined and further stated that it required analysis as it was inconclusive in nature.
However, the judgement on appeal by the Lahore High Court directed the police to complete investigations before arresting any person named in the Minhajul Quran Secretariat application or the FIR. Meanwhile, government officials announced to the media that the findings of the Judicial Commission to investigate into this incident were not binding on the government as there were no conclusive findings.
Following the order of the session's court, which allowed family members of those killed to file a First Information Report, Lahore police refused to file the FIR. Lahore police have reminded them that that government is intending to file an appeal against the sessions' court order before the high court and therefore the police cannot entertain the request to file the FIR. The police deliberately ignoring substantial evidence and statements of eyewitnesses had instead lodged a one-sided FIR on the complaint of a police official. 72 days have been passed of the incident but still FIR has not been filed.
Meanwhile, the Joint Investigation Team (JIT), consisted of police, civilian and military intelligence officials, has also declared the chief minister of Punjab and the government responsible for the incident of killing of 14 persons in Model Town, Lahore.
The government's continuous escapades from adhering to court orders and not allowing police to register a First Information Report is a blatant manifestation that the government wants to rule the country by undermining the law.
This is a clear depiction of the non-existence of the rule of law in Pakistan. Worse, not only is it the non-existence of rule of law but by the denial by the police, for any victim to file a FIR to pursue their grievances is a total failure of the system of criminal justice in Pakistan. In the presence of such a flawed criminal justice system impartial investigation becomes a redundant phenomenon , a phenomenon which could always however be made to work based on the whims and fancies of the elite and the politically affluent and not based on rule of law and a system of justice. The denial of this basic right to victims for filing a first complaint against any alleged perpetrator/s is in real terms a denial of the basic justice.
Further, a First Information Report if lodged does not automatically find those named in the report as guilty – in this instance the filing of the FIR would not amount to the prime minister, chief minister and other 19 federal and provincial ministers including the high police officials being guilty of the crimes alleged and would eventually be arrested. This fact was also explicitly explained in the court order that "arrest of a suspect was not necessary during the course of investigation and general impression in this regard was misconceived because a person named in FIR was not to be arrested straightaway upon registration of the case or as a matter of course unless there was sufficient incriminating evidence culpability of the accused"
Therefore, the government must take the initiative and allow the aggrieved parties to file the FIR as ordered by two of Pakistan's courts and allow the law to take its own course.
This would be biggest incompetence still on the part of the Pakistan government in trying to halt the due process of the law, by interfering with the administration of the criminal justice mechanisms.
The Government has sent a clear message to the people of Pakistan that influential and powerful persons can escape the law with impunity but that law does not apply to them but the law applies only on the poor.
In a country where there does not exist a proper criminal justice system nor a system based on the rule of law, the government by denying the rights to its citizens even to file an FIR, falls deeper into an abyss from where there will be no escape - creates apathy and a situation of lawlessness from which there is no return.


text: Entrepreneurship for Purpose and Social Impact 02.07.17 5:00 PM - 8:30 PM Location: Edwins Leadership & Restaurant Institute, 13101 Shaker Square, Cleveland, OH 44120 Entrepreneurial models as a method of driving social change is an approach that is having a significant impact in the country and here in Northeast Ohio. Nationally recognized leaders such as Brandon Chrostowski, founder and CEO of the nonprofit Edwins Leadership and Restaurant Institute, and Mansfield Frazier of The Vineyards and BioCellar of Chateau of Hough, are driven to impact their community and change the lives of others. Greater Cleveland Partnership Middle-Market Investors are invited to join us at Edwins restaurant at 5 p.m. February 7 when Brandon will share his story of creating a culinary arts job-training program for individuals re-entering the workforce after prison. He will also provide a preview of what's next in his growing endeavor to change lives and build a world-class business. Mansfield, who created his organization to leverage current social trends to help solve urban ills including a lack of urban food production, will talk about his successes and challenges in working to create wealth-building opportunities for local residents. We will close out the night with the opportunity to experience some of the amazing food prepared by Brandon and his team at this classical French restaurant. The entire Edwins restaurant, located at 13101 Shaker Square, will be reserved for our group for the evening. Following the presentation from 5 to 5:45 p.m. and a reception beginning at 6 p.m., we invite you to join us for a private three-course dinner from 6:30 to 8 p.m. You may also invite a colleague, significant other, or friend to join us. 5 to 5:45 p.m. – Panel Discussion and Q&A 5:45 to 6:15 p.m. – Reception 6:30 to 8:30 p.m. – Dinner Registration This will prove to be a memorable evening for all in attendance. Seating is limited, so we encourage you to register soon by contacting Reagan Leatherman at firstname.lastname@example.com or 216.592.2376. The dinner cost will be $65 per person and includes two beer and wine drink tickets, hors d' oeuvres, and a three-course dinner. Additional details are below. The menu Reception appetizers: Salmon rillettes atop crostini Cheese platter Gougeres and endive with chicken Provencal Dinner first course choice of: Soup du jour Local field greens with herbs, fried shallots & sherry-hazelnut vinaigrette Escargot with fennel, garlic, butter & parsley Second course choice of: Paupiette - Grouper wrapped in crispy potatoes with haricot verts and beurre rouge Guinea hen, smashed fingerling potatoes, roasted brussel sprouts with Calvados cream sauce Portobello Napoleon with roasted red pepper, grilled squash and zucchini, roasted cauliflower and red pepper coulis Black pepper encrusted Painted Hills Farms New York strip steak with goose fat fried potatoes and Cognac cream sauce Third course choice of: Creme Brulee Chocolate Pyramid Beignets


text:
Merlin's weekly podcast with Dan Benjamin. We talk about creativity, independence, and making things you love.
Merlin's weekly podcast with Dan Benjamin. We talk about creativity, independence, and making things you love.
"What's 43 Folders?"
43Folders.com is Merlin Mann's website about finding the time and attention to do your best creative work.
My kGTD setup
Merlin Mann | Dec 7 2005
Related to today's earlier post, a number of people have written over the past few weeks with curiosity about kGTD ("Is it worth buying OmniOutliner Pro?" "Is it worth buying a Mac?" "Will I be able to vanquish all foes?"). While I'm not prepared to do a major sales presentation, I am happy to oblige the folks who wanted to see how I've set mine up. Also gives you a little window into my current contexts (as well as my atrocious personal habits).
Screenshot here (best viewed full size): comments and questions will be entertained.
Sorry for the late responses...
Submitted by Merlin on December 12, 2005 - 7:08am.
Sorry for the late responses all — I hope this is helpful….
You remind yourself to do system backups?
Mark: I do automated incremental nightly Psyncx backups, then do a twice-monthly cloning of my disk image using SuperDuper.
Thanks for posting that, Merlin. Just wondering why you're using "+" as the suffix for "waiting on" instead of "-"?
Señor: Hm. Maybe I have that wrong. I thought that was the correct way to demarcate future (non-actionable) contexts. Seems to be working so far.
I'm mainly interested in how you freed yourself from Entourage. I'm so deeply invested in it I can't imagine breaking free. And yet I yearn, I yearn…
Communicatrix: It was astoundingly easy I must say. Omni Outliner + iCal + kGTD does (or affords) everything I needed Entourage for.
The thing I was thinking I'd really miss is attaching files, but OO actually does that better letting you control-drag files into any OO line for an instant alias. Ditto for pasting in URLs.
iCal and kGTD aren't quite up to speed with ENT on alarms —- esp. for recurring events — but I can deal. Just means I have to be a little more aware of when to get a haircut and sweep the floor. :)
I've been going back and forth on the Next Actions summary option and it looks like you are using it. Is it working for you?
Karen: Yes, it's been working great. I treat it like a kanban—I do dashes to knock down every item in the NA area, then Sync, take a break while it's running, and come back for more.
I do think that kGTD — VERY much unlike Entourage — benefits from making true GTD-style projects. By this I mean very atomic 2-5 item areas for everything. I've found that if I use the more Entrouragey habit of treating projects as Spheres of Life, kGTD doesn't work as well. You really need to track all the projects separately in order to bubble up all the true next actions.
Would you be willing to briefly expound on your usage of "future" contexts (including future "waitingfor")?
Brendon: Sure thing.
|EXPLORE 43Folders


text: Being as I am not a fan of mechanical broadheads I am trying to find a fixed blade broadhead that shoot good from the Storm. I would prefer that I could use Slick Tricks but so far I am not able to get them to shoot good at all from the Storm. Spitfires shoot fantastic, to near same point of impact as field tips. I am looking for info from anyone who has a Storm and has gotten fixed blade B/H's to shoot good. Never had an issue with any other crossbow. They all would shoot Slick Trick as accurately as field tips. For some reason the Storm is not accomodating to using Slick Tricks


text: I'm on a quest to find a pair of speakers that have had as much work put into their design as the sound itself. In other words, I need speakers on my desk that won't look like eye sores in comparison to an iMac. A couple on my list of considerations right now are: http://www.ilounge.com/index.php/mac/entry/altec-lansing-expressionist-classic-fx2020/ http://www.gadgetmac.com/news/2011/5/18/ufi-ucube-speakers-complement-your-imac-with-aluminum.html http://store.apple.com/us/product/TX583VC/A/bowers-wilkins-mm-1-speakers Any other recommendations, thoughts or ideas are more than welcome. Thanks so much!


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Warner Bros
By Jay Boyar, Sentinel Movie Critic
July 23, 2004
Rating: PG-13 for action, violence and some sensuality. What it's about: A mousy graphics designer becomes the confident Catwoman. The Kid Attractor Factor: It's somewhat based on a comic-book character. Good lessons/bad lessons: Crime doesn't pay. Violence: Comic-book-style action. Language: A word here and there. Sex: Catwoman wears an outfit that looks like something out of a bondage catalog, complete with whip. There are other suggestions of sensuality. Drugs: No. Parents' advisory: Not for the little ones.
Orlando Fringe review: 'Skill Focus: Burlesque Strikes Back'
By Tod Caviness, Orlando Sentinel Entertainment Critic
May 16, 2013
With their colorful, often skimpy costumes, the heroines (and heroes) of sci-fi, video games and comic books are a no-brainer when it comes to fodder for burlesque. But like any true nerds, the guys and gals of Skill Focus: Burlesque put a fair amount of brains into the show anyway. This manifests in a lot of ways during their three rotating shows, each dedicated to a different geek obsession. The costumes are clever (and easily removable) takes on genre favorites, with some even allowing for a playful bit of gender-bending.
Jolie as Catwoman? Newmar approves
By Hal Boedeker and Roger Moore, Sentinel Staff Writers
August 2, 2008
These sound like "shoot the moon" trial balloons, but rumor has it that Angelina Jolie is "interested" in playing Catwoman in the next Batman movie, the one they'll make if The Dark Knight ever runs out of gas at the box office. Ex-Catwoman Julie Newmar is in favor of that casting move. Sure, Jolie needs to eat a few cookies -- judging by recent photos and her emaciated turn in Wanted, the lady needs to bulk up. And do producers want Johnny Depp as The Riddler (interesting) and Philip Seymour Hoffman as The Penguin?
Tim Burton: Michelle Pfeiffer's Catwoman was purr-fection
By Geoff Boucher
August 13, 2012
Tim Burton has watched plenty of world-class actors while directing 15 feature films, but he sensed there was "something really special happening" when Michelle Pfeiffer played the practically purr-fect Catwoman in " Batman Returns," which is celebrating its 20th anniversary this summer. "I don't really go back and look at the movies but her performance in that was one of my favorite performances of anything by anyone in any movie that I've worked on," Burton said recently.
Catwoman Purrs In Batman Sequel
By Jay Boyar Sentinel Movie Critic
April 24, 1994
Returning to bat in Batman Returns is Tim Burton, who directed the 1989 Batman.For the 1992 sequel, Burton digs deep into comic-book lore, coming up not only with the fiendish Penguin, but also with the sharp-clawed Catwoman, whom he re-invents.In Burton's version, Catwoman is a meek secretary who turns flashy super-villain after being pushed out a window by her boss, the power-crazed - and power-plant-crazed - mega-businessman Max Shreck.Returning as Batman in Batman Returns is Michael Keaton, who, once again, gives the shadowy hero the deep shadings that warded off the campy ghost of Adam West and captured the paranoid atmosphere of the late 1980s.
Pfeiffer Replaces Bening In The Catwoman Seat
August 1, 1991
With Annette Bening out, Michelle Pfeiffer is in as Catwoman in the sequel to Batman, Warner Bros. announced Tuesday.Bening, star of the current film Regarding Henry, dropped out of the sequel because she is expecting a baby with Warren Beatty, which makes fitting into those catsuits a little difficult.
Hairballs Are More Exciting Than This
By Jay Boyar, Sentinel Movie Critic
July 23, 2004
Look what the cat dragged in. It's Catwoman, arguably the worst superhero film ever made. Remember Batman & Robin, the travesty that killed the Caped Crusader's film franchise back in 1997? Remember how everyone laughed at how inappropriately kinky it was? Well, Catwoman is all kink and no think. As the title character, Halle Berry cracks a whip, wears what looks like a bondage mask and sports a hot shredded-leather catsuit. Our heroine's mysterious mentor, like a porn-film guru, expounds a libidinous-sounding philosophy.
Q: Was Eartha Kitt the only black woman to play Catwoman...
July 14, 1992
Q: Was Eartha Kitt the only black woman to play Catwoman on the original Batman TV series?- A: Yes, Kitt was the only black woman to play the role of Catwoman. The other two actresses who played the feline villainess were former Miss America Lee Meriwether and Julie Newmar.
If You Say So
July 8, 1992
Catwoman is about a woman discovering her empowerment and part of that is sexuality. I look at the movie metaphorically. Catwoman's in vinyl, and Batman's in rubber, and they inflict pain on each other. Isn't that the same way in life?- Actress Michelle Pfeiffer, on her Batman Returns role, in the Washington Times
Talkies (special Bat-edition)
By Jay Boyar, Sentinel Movie Critic
June 26, 1992
The most quotable quotes from Batman Returns:- ''Honey, I'm home! . . . I forgot, I'm not married.'' Selina ''Catwoman'' Kyle (Michelle Pfeiffer), upon returning to her apartment after a day at the office.- ''One can never have too much power.'' Mega-millionaire Max Shreck (Christopher Walken), expressing his philosophy of life.- ''Be gentle, it's my first time.'' Catwoman to her first opponent.- ''You gotta admit: I played this stinkin' city like a harp from hell.'' The Penguin (Danny DeVito)
Omarr's daily astrological forecast
By Jeraldine Saunders, Tribune Media Services and Omarr's Astrological Forecast
June 11, 2012
BIRTHDAY GAL: Actress Adrienne Barbeau was born in Sacramento, Calif., on this day in 1945. This birthday gal first appeared as Carol on the hit series "Maude" from 1972-78. She would go on to star in such hit films as "The Fog," "Creepshow" and "Escape From New York. " She's come to personify the voice of Catwoman in several animated series and in 2010 appeared on the long-running TV soap "General Hospital. " ARIES (March 21-April 19): Act like you are invincible and others may actually believe it. Your creative energies are running high, so make the most of it. Hold off on making any major purchases or investments until conditions improve.
'Dark Knight Rises' prologue at Regal Pointe Orlando on Dec. 16
December 5, 2011
Mark your calendars, Batfans. According to Warner Bros., the 6-minute "Dark Knight Rises" prologue arrives at Regal Pointe Orlando Stadium 20 + IMAX on Dec. 16, playing before showings of "Mission: Impossible - Ghost Protocol. " The prologue introduces Bane, a villain played by Tom Hardy ("Inception"). The movie, directed by Christopher Nolan and with Christian Bale as Bruce Wayne/Batman and Anne Hathaway as Selina Kyle/Catwoman, is scheduled to open July 20. Bale has indicated that this would be his last foray as the Caped Crusader.
TV honors Black History Month
By Hal Boedeker, Sentinel Television Critic
February 1, 2009
Television pays tribute to Black History Month, which starts today, with a range of programs. TV critic Hal Boedeker highlights 10 worthy of attention: 1 CBS Reports: Road to the White House, CBS, 7 tonight: Steve Kroft of 60 Minutes had unusual access to Barack Obama in the two years before the Illinois senator won the White House. The program traces Obama's run and victory. 2 Adjust Your Color, PBS, Tuesday: Independent Lens profiles radio shock jock Petey Greene, who was also a hustler, drug addict and convicted felon.
Jolie as Catwoman? Newmar approves
By Hal Boedeker and Roger Moore, Sentinel Staff Writers
August 2, 2008
These sound like "shoot the moon" trial balloons, but rumor has it that Angelina Jolie is "interested" in playing Catwoman in the next Batman movie, the one they'll make if The Dark Knight ever runs out of gas at the box office. Ex-Catwoman Julie Newmar is in favor of that casting move. Sure, Jolie needs to eat a few cookies -- judging by recent photos and her emaciated turn in Wanted, the lady needs to bulk up. And do producers want Johnny Depp as The Riddler (interesting) and Philip Seymour Hoffman as The Penguin?
Flashy fusion of sweat, beat
By Darryl E. Owens, Sentinel Staff Writer
May 16, 2006
Inside a warehouse in Orlando, students in sweat-streaked workout gear assemble in two lines. One by one, in concert with a partner across from them, they start an unspoken dialogue of movement: They move down the length of the warehouse, entranced by a percussive conga beat, encouraged by classmates' claps, performing push-ups. Their dialogue complete, they return to the end of their lines, reveling in the rhythm, parroting Portuguese chants rising above the congas: Capoeira! Capoeira!
Heroine In Black Leather
January 21, 2005
* Catwoman (Warner; 100 minutes; rated PG-13 for action, violence and some sensuality; priced for rental, $27.95 for DVD): Look what the cat dragged in. It's Catwoman, arguably the worst superhero film ever made. As the title character, Halle Berry cracks a whip, wears what looks like a bondage mask and sports a hot shredded-leather catsuit. Our heroine's mysterious mentor expounds a libidinous-sounding philosophy: "Catwomen are not contained by the rules of society. You follow your own desires."
Georgia police said Thursday they are...
August 18, 1989
'CATWOMAN' SUSPECT. Georgia police said Thursday they are seeking to extradite a Canadian woman they believe to be the infamous ''catwoman,'' a thief who has burglarized homes in Atlanta. Detective Rudy Lindsey of Atlanta said American officials have contacted the Canadian government in an attempt to extradite Alice Marie McGraw. McGraw, 33, is accused of stealing more than $1 million in jewels and cash, is wanted for two charges of theft and faces up to 15 years in prison if convicted.
Weekend Box Office
July 26, 2004
Matt Damon's The Bourne Supremacy, the sequel about the amnesiac assassin he played in The Bourne Identity, debuted as the top weekend movie, with ticket sales of $53.5 million. Halle Berry's (right) critically derided comic-book adaptation Catwoman opened a distant third with $17.16 million, behind I, Robot. Catwoman, which cost a bit less than $100 million to make, was a disappointment for distributor Warner Bros. 1. The Bourne Supremacy $53.5 million 2. I, Robot $22 million 3. Catwoman $17.16 million 4. Spider-Man 2 $15 million 5. A Cinderella Story $8 million 6. Anchorman: The Legend of Ron Burgundy $7.1 million 7. Fahrenheit 9/11 $5 million/ 8. The Notebook $4.45 million 9. King Arthur $3 million 10. Shrek 2 $2.4 million
Weekend Box Office
August 9, 2004
Good guy or bad guy, Tom Cruise is still No. 1. Cruise's Collateral, in which he plays a psychotic hit man who hijacks a taxi for a one-night killing spree, debuted as the top movie. Collateral bumped off the previous top movie, The Village. The weekend's other new wide release, the Brittany Murphy romantic comedy Little Black Book, opened weakly in fifth. Top films' ticket sales: 1. Collateral $24.4 million 2. The Village $16.6 million 3. The Bourne Supremacy $14.1 million 4. The Manchurian Candidate $10.8 million 5. Little Black Book $7 million 6. I, Robot $6.3 million 7. Spider-Man 2 $5.5 million 8. Harold & Kumar Go to White Castle $3.2 million 9. A Cinderella Story $3.05 million 10. Catwoman $2.9 million
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Often audio amplifiers and equipment use a small-valued capacitor across the input(s) to present a virtual short-circuitto radio-frequency signals - this really helps prevent the unintended radio-receiver effect (the non-linear elements inthe amplifier circuit can inadvertantly act like an amplitude-modulation detector at radio frequencies).Even quite a small value capacitor like 100pF can severely attenuate radio frequencies (MHz and above) without doing muchat all at audio frequencies.Often the source of unwanted noise is from the cables (which here can be acting as radio aerials / antennas). Mainswiring often has sporadic noise spikes (clicks) when switches and thermostats are operated - main wiring is everywhere inbuildings and thus tends to inject such noise into any other wiring running near it.
Electronic noise is any fluctuation in voltages that you don't want.It could be from the operation of a chip, capacitors help smooth this.Here is one example of noise being generated and being suppressed.http://www.thebox.myzen.co.uk/Tutorial/De-coupling.htmlNoise can also be generated by thermal agitation of electrons, this is know as thermal noise. There are other mechanisms that generate noise but in digital electronics this is normally too small to be a problem.Noise can also be injected into a circuit through radiation when the circuit is acting unintentionally like a radio receiver.
but i failed to understand how the IC'S here are producing the varying current and here it is shown that the varying current is going to the ICA and thus the other current going to ICB and ICcare also changing due to changing current produced by ICA .


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Used Pentax K-5
- High Resolution 16.3MP CMOS Sensor
- Speedy 7 FPS Captures Fast Action Shots
- High Sensitivity 80-51200 ISO Range
- Responsive, Accurate 11-Pt Autofocus
- 1080p HD Video at 25 FPS
- 3″ LCD With 921,000 Dots of Resolution
- Fully Weather-Sealed and Coldproof
- Magnesium Alloy & St Steel Chassis
- Highly Accurate 77-Segment Metering
Out of stock
Product Description
Pentax steps up and delivers a rugged top-of-the-line APS-C camera–the K-5 Digital SLR Camera Body (Black), low-noise 16.3MP CMOS high resolution sensor, sensitivity up to a best-in-class ISO 51200, 7 frames-per-second shooting capability and a responsive, high-precision 11-point auto-focus system. A high performing PRIME II imaging engine produces rich-gradation, very high resolution digital images. Plus, full HD video at 1920 x 1080 pixels.
The K-5 makes advances in plenty of other areas as well, such as faster autofocusing speed, and an upgraded High Dynamic Range (HDR) function–for automatically combining 3 photos taken rapidly in challenging situations, for improved contrast and tonal range–that can even be used without a tripod. A bright, clear 3″ LCD display with 921,000 dots resolution makes it easy to compose and review your images, or use the bright viewfinder for composition, secure in the knowledge that the highly accurate 77-segment metering system will deliver the goods every time. Shake Reduction image stabilization makes it possible to shoot at 2.5 to 4 shutter speeds slower without seeing camera shake in your photos.
And all of this photo goodness is packed into a body of sturdy, lightweight magnesium alloy on a chassis of stainless steel that's built to last. The 77 special seals in the body give you a dustproof, weather-resistant and cold-resistant camera, for reliable operation in harsh conditions, at temperatures as low as 14°F (-10°C). An extremely reliable shutter unit provides a top shutter speed of 1/8000 second and is tested to 100,000 shutter releases. A stellar performer.
Accessories Included:
- 2 Batteries
- Battery Charger
- Neck Strap
- User's Manual
Additional Information
|Product Condition
"Like New Minus" – the rating of the equipment is at 97 to 99 percent of original condition. Only the closest inspections will reveal slight wear. Perfect glass, but the box and accessories are usually not included.
There are no reviews yet.


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Reviews and Testimonials
Since 1920, the Quincy Compressor name has stood for industry-leading quality in air compressors and related equipment. In nearly every industry driven by compressed air technology, our reputation speaks for itself. You'll find Quincy air compressors raising the bar for performance and efficiency in automotive, manufacturing, food and beverage, energy, medical, and a wide range of other applications. Designed to deliver reliable, stable pressure, low operating and maintenance costs, and ongoing energy savings, Quincy products are a great choice for any growing business.
Still not convinced? On this page, you'll find information about some of the awards we have received. You can also read customer reviews of our professional air compressors and commercial products.
Thanks to all your employees for making such a fine product.
– Henry Gradowski of Elsberry, MO
Awards and Recommendations
Quincy air compressors have been recognized by both customers and industry insiders alike. We have been the recipient of numerous awards, including the 2010 Manufacturing/Automation Summit Gold Award for compressed air products, which was given to the QGD rotary screw air compressor. We've also received the Liberty Mutual Gold Safety Award, the EnPro Industries Presidential Safety Award, and the Managing Automation Progressive Manufacturing Award, among others.
Awards and reviews of Quincy air compressors speak to not only the innovation that drives our products, but also our commitment to progressive manufacturing and management practices. In 2014, Quincy Compressor received ISO14001:2004 certification, recognizing our commitment to best practices and continuous improvement in environmental management.
In my professional opinion Quincy Compressor makes one GREAT air compressor.
– Steven Couzzo, GKN Aerospace Monitor, Inc.
Committed to Continuous Improvement
Reviews of Quincy air compressors are useful to potential customers and provide an important window into the priorities of current owners. This insight can help guide future product developments.
Total Customer Value (TCV) is the foundation of our management philosophy, and it represents a commitment to reducing costs, improving efficiency and researching new solutions to the engineering challenges our customers face every day. You can see the results of TCV in any of our current generation of air compressors, air treatment equipment, vacuum pumps and other products.
That's one of the toughest pieces of equipment I've ever seen.
– Ken McCooley, Fort Campbell, KY
Read Commercial Air Compressor Reviews Online
Click here to see more of what some of our valued customers have been saying about Quincy products. For more information or assistance choosing the right air compressor for your application, contact a sales representative today.


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Lingering concerns about the political future of Greece pushed U.S. and global stock markets modestly lower on Tuesday. Trading was slow as most investors have closed their books for 2014. It was the eighth-slowest day of the year on the New York Stock Exchange.
On Tuesday:
The Dow Jones industrial average fell 55.16 points, or 0.3 percent, to 17,983.07.
The Standard & Poor's 500 index lost 10.22 points, or 0.5 percent, to 2,080.35.
The Nasdaq composite fell 29.47 points, or 0.6 percent, to 4,777.44.
For the week:
The Dow is down 70.64 points, or 0.4 percent.
The S&P 500 is down 8.42 points, or 0.4 percent.
The Nasdaq composite fell 29.42, or 0.6 percent.
For the year:
The Dow is up 1,406,41 points, or 8.5 percent.
The S&P 500 index is up 231.99 points, or 12.6 percent.
The Nasdaq is up 600.85 points, or 14.9 percent.


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Online MA in TESOL!
save time with pencil dice!
Just a time-saving tip - an idea which my dad came up with a few years ago for party games. Instead of the prompt cubes made out of folded paper mentioned in some of the recipes, just get some plain wooden pencils and write the six prompt words on the six "sides" or edges. These can then be rolled - obviously the word that lands up on top is the prompt. No cutting, folding or messy gluing required.
Colin, Varese, Italy
World's Best Jobs!
Dave's ESL Cafe Copyright © 2016 Dave Sperling. All Rights Reserved.


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EOD front yard sunset documentation.
EOD front yard sunset documentation.
And the nights are not full enough.
Time to trade seven teens for seventies
"…maybe now and then have enough for a beer at Tee-Gees Saturday night."
Kissing booth cathedral.
<Searching> the shore's edge you <find> much needed supplies, but <expend> much energy. AP -15. Int +2. Dex -15. Birch +fern.
Crunch berries happening now.


text: Arduino Uno's Pin labelling is displayed in image below, and detailed function of each & every pin is mentioned below the image. PIN FUNCTIONS : USB To PC : It is used to communicate Arduino via Universal Serial Bus to PC for programming/sending data to Arduino serially. 7V to 12V DC Input : For external… Read Article →


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NoteBurner Audiobook Converter FAQ
Q1. How can I set the output format in the Audiobook Converter?
Please go to Menu > Preferences > Advance > Output File format and choose Custom. In the format section, you can choose to convert your audiobook to MP3, AAC(m4a), AAC(m4b), WAV format. Besides, in the same window, you can even custom your output file with setting like Bitrate, Bitrate Type, Sameple Rate, Channles, etc.
Q2. Can I keep the chapter info in the converted file?
The latest version of iTunes DRM Audio Converter for Mac enables user to retain chapter info when convert audiobook to AAC. But you need to do some setting to make it happen.
To learn more, please refer to "How to keep the chapter info in the converted file?"
Q3. There is some noise in my output audio file? How can I fix it?
Before conversion, please go to the program terminal by clicking to Finder > Applications > Utilities > Terminal, then input the following command code to run start the conversion "defaults write com.macsome.AudiobookConverterConvertSpeed -int 1".
If problem persists, please tell us the file name, the screenshot of the program setting and the program log file for analysis.
Q4. I can't convert a protected audiobook file which is shown with a lock on it.
Please note that Note Burner Audiobook Converter supports converting drm audiobook from iTunes and Audible, but currently doesn't support converting protected audiobook from Amazon.
Q5. How to convert mp3 format audiobook file?
Please first import file to iTunes music directory, then right click on the file, click to Get Info > Options > Media Kind > Audiobook.
When the file show up in Books directory, you can relaunch NoteBurner Audiobook Converter to convert the file.
Q6. Can Audiobook Converter split my audiobook? How?
Yes. After conversion you can click on the Split button to split file according to your needs.
You can choose to split file either by file duration or by chapters.
Q7. Audiobook Converter crash when conert a certain audiobook file. Is there a fix?
Please try to restart computer and go to safe mode to convert file with Audiobook Converter. If your file is stored in external storage device, please copy the file to local disk in your computer then try again. If problem persists, please provide us with the info below:
(1)What's your Mac OS version and the iTunes version?
(2)What is the name of the audiobook file? Can it play normall in iTunes?
(3)Please send us the log files. If program crash, please also send us the crash log file.
How to find the program log file:
Please press "option" and at the same time launch NotBurner Audiobook Converter, then there will generate a Audiobook Converter.log on your desk screen. Another log file will locate in /Users/username/Library/Application Support/NoteBurner/itunes.log
Please send us both log files above, we will submit to our R&D department and give feedback ASAP.


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� Business name: Jenuinely Pure
� Business name: Jenuinely Pure
� Location: Ames.
� Phone number: (515) 451-1760.
� E-mail address: firstname.lastname@example.com.
� Web site: www.jenuinelypure.com.
� Type of business: Retail skin care and cleaning products. �Our company was chosen as an �official skincare partner� at the third annual Taste Awards, a red carpet event in held Jan. 12 in Hollywood, Calif.,� said Isaac Drew, marketing and public relations representative for the company. He said Jenuinely Pure �was chosen by a panel of celebrity judges as the �best skincare products in North America. Representatives of the company attended the event in California.
For more, visit: http://www.youtube.com/watch?v=2CYBGZDQEg4
� Product or service: All-natural and organic products for the body, face, baby and home.
� Number of employees: Four.
� Year and location of company origin and founder(s): 2008 in Ames, Iowa; Founder - Jenny Drew.
� One thing you would like Mid-Iowans to know about this company? �We believe what you put on your body has a tremendous impact on your health and our mission is to provide you with safe and effective products you can use with confidence,� Jenny Drew said.


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Platform: 3DS
Developer: High Voltage
Film tie-ins usually suck, it's true. But the 3DS version of Captain America: Super Soldier has had three or four months or so longer than its relatives to iron out kinks. Supposedly.
Brendan already reviewed this game's larger console cousin earlier this year and found it to be a pretty enjoyable experience: a flawed but perfectly playable hero simulator that allowed you to wield the shield in style, with a number of collectables and little Zola Missions to engage in amongst the linear levels and straightforward action to keep things interesting.
This portable version doesn't do much to differ from it's HD buddies, apart from look worse, but that's to be expected. Truth be told, the visuals aren't horrible, although the first level that literally sees you entrenched and running down Nazis does a pretty good job at trying to persuade you otherwise. The game actually perks up quite nicely visually and the 3D effects, whilst not particularly essential, do add the usual pleasant sense of depth to proceedings.Click here to read more...


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FREE Download: Guide to Software Usabilty Principles
Learn to Create SCADA/HMI Solutions Your Users Will Love!
The usability of software comes down to the end user's ability to easily learn it and then readily use it to accomplish a desired task.
Even the most powerful of software solutions will fail if the end user finds it too difficult to use. Progea's Guide to software Usability principles will explain the principles behind usability and how you can use them to create a SCADA/HMI Software solution for the user that features:
- Natural dialogue between the user and software solution
- Simple task structures
- Tolerance for user errors and easy recovery
- Efficiency and flexibility for user interaction
When you provide a usable solution for your client, not only do you create a satisfied user, but you reduce the need for technical support, decrease training time and costs and create a positive perception of your solution.
Download our FREE guide today by completing the form on the right, and learn how you can give your clients a SCADA/HMI solution they will find both useful and easy to use.


text: Blog Partner of the Month Loving Teckels Animal Sanctuaries Posted on 01 February 2017 by Charity Car Call us old romantics here in the Charity Car office but February means love, it is home to Valentine's Day after all! And we're making it easy for you, because our Partner of the Month is Teckels Animal Sanctuaries. This hard-working little charity rescues and rehabilitates over 120 dogs and 250 cats every year, and we'll be showing you some of their lovely furry residents on Facebook throughout the month... so prepare to melt! Teckels vision is: A world where all animals are well cared for, respected and their needs understood. And that's key to everything they do, because it's not just about finding the first home they can, it's about finding the right home for that individual animal. If you can't wait to take a look and see if your home could be the right environment for one of Teckels' cats and dogs, you can see some of them on their website. Please let us know if you end up re-homing any of these beautiful animals - the Charity Car team would love to see your photos. Love gets the Teckels staff a long way and they pride themselves in superior care of all their animals which includes cleaning, feeding, exercising, playtime, behavioural support and rehabilitation so each animals' needs are met and they feel safe and happy. But love is free, and of course Teckels incur a lot of day-to-day costs that they rely on supporters to help provide. The Teckels team is hoping old cars will provide a welcome boost to those donations and help raise money towards an even bigger target... the replacement of the roofs and floors of all their kennels, which will cost over £100,000. So, any old car donations could help to provide valuable long term care for numerous animals rescued by Teckels. That definitely gives us a warm fuzzy feeling! You can find out more about donating your car on the Charity Car website. As well as collections, events, and of course Charity Car donations, Teckels provides microchipping, grooming and high-quality boarding services for cats and dogs. Owners can enjoy total peace of mind while they are away, knowing that Teckels always put animal welfare first. Teckels are proud members of LiKCA (Licensed Kennels & Cattery Association) and ALIKC (Association of Licensed Kennel and Cattery Owners). Not only does this mean happy cat and dog owners have a safe and knowledgeable boarding facility to leave their loved pets with, but the income from their non-profit boarding facility goes straight to the Teckels charity to help the animals who aren't lucky enough to have a home - amazing! So, enjoy the month of love and all our updates from Teckels on social media - we challenge you not to fall head over heels for a new furry friend! Subscribe to weekly blog updates Categories Latest News Keep up to date with the latest news Partner of the Month All about our Partners of the Month Just For Fun Charity activities and silly stuff! Categories Latest News Keep up to date with the latest news Partner of the Month All about our Partners of the Month Just For Fun Charity activities and silly stuff!


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HPU Adds Smith to Admission Staff
HIGH POINT, N.C., Nov. 7, 2013 – The Office of Undergraduate Admissions at High Point University recently hired Sally Smith as a regional admissions counselor.
Smith is responsible for working with prospective HPU students and aiding in the admissions process.
"I will be able to impact students by encouraging excellent applicants who will enhance the culture and contribute to the long range success of the extended community," says Smith.
Smith was awarded the Alumni Achievement Award from Plymouth State University, and she is a certified mediator and certified educational planner. She received her Bachelor of Arts in political science from the University of New Hampshire and a Master of Education in counseling human relations from Plymouth State University.
"It is remarkable to be able to promote an institution of higher education that serves so many and is a model for success. I enjoy being part of a culture that is caring, and student-centered with high standards of service," says Smith. "Also, as a parent of a current student, I can personally attest to the results of a community that challenges students while nurturing their talents to prepare them for life after college."


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Is this fast enough to stream Lost from the plane?
Blog, Blog, Blog
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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.


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Notes to Nineteenth Century Geometry
Notes to the Supplementary Document
1 The informal characterization of n-manifolds in the supplement is not altogether accurate and may cover some far-fetched monsters that we do not wish to cover with this concept. For readers who have a smattering of topology the following characterization is preferable.
(a) Let M be a set of points. Pick a collection of partially overlapping subsets of M, or patches, such that every point of M lies in at least one patch.
(b) If U is a patch of M, there is a one-one mapping f of U onto an open space of Rn, whose inverse we denote by f−1. (Rn denotes here the collection of all real number n-tuples, with the standard topology generated by the open balls.) f is a coordinate system or chart of M; the k-th number in the n-tuple assigned by a chart f to a point P in f's domain is called the k-th coordinate of P by f; the k-th coordinate function of chart f is the real-valued function that assigns to each point of the patch its k-th coordinate by f.
(c) There is a collection A of charts of M which contains at least one chart defined on each patch of M and is such that, if g and h belong to A, the composite mappings h○g−1 and g○h−1 — known as coordinate transformations — are differentiable to every order wherever they are well defined. (Denote the real number n-tuple (a1, ... , an) by a. h○g−1 is well defined at a if a is the valued assigned by g to some point P of M to which h also assigns a value. Suppose that the latter value h(P) = (b1,...., bn) = b; then, b = h○g−1(a). Since h○g−1 maps a region of Rn into Rn, it makes sense to say that h○g−1 is differentiable.) Such a collection A is called an atlas for M.
(d) A given atlas A for M can be extended in one and only one way to a maximal atlas Amax as follows: add to A every one-one mapping g of a subset of M onto an open set of Rn which, combined with any chart h of A, satisfies the condition of differentiability stated under (c).
(e) M is given the weakest Hausdorff topology that makes every chart g in Amax into a homeomorphism. (A topological space is said to be Hausdorff if any two points in it have open neighborhoods that do not overlap.)
The pair (M,A) is an n-manifold.


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I am feeling very frightened and anxious after seeing my Dad today. He is 88, still works and in good health - even after two heart attacks, a triple by-pass six years ago and a six-bypass surgery four years ago. Today he came to visit from Florida and we had lunch together. He said he feels like an old man now and has been weak for the past two years and can't travel like he used to. He said he worries about me a lot and will not be around forever to take care of me when I get laid off my jobs or lose them with bills etc. I told him about my recent job disappointment at the Investment company and he was not happy about that. He wants to see me with a stable job, I told him I was trying, but that times were tough for everyone, and unfortunately, jobs come and go and the economy is not good, many people are losing their jobs. He worries as I don't have a nest egg, and have been unable to keep a job for any length of time. I told him I would be okay, but not sure if I will be..I have no idea what I will do when he passes. I keep thinking, when he goes, I will too, as I will not be able to take care of myself, rent, car payment, bills, school loans. It is very hard to work with depression and anxiety problems, even on medication, as medication can stop working..and have to start all over again.
Well, sorry this letter was depressing, I am having an off day and was wondering if anyone goes through this when they visit their aging parents and have this kind of talk with them. It is scary and I am feeling panicked and anxious. Unfortunately, I have had to be financially dependent with my Dad, as there have been times I have been unable to pay rent, car payment or bills the times I have lost jobs. This happens (anxiety and sadmess) everytime I see my Dad and I realize his health is starting to deteriorate. I worry so much about what will become of me. I am single, live on my own and no boyfriend or family other than my Dad.
Thanks for listening.
Dear Rianna,
Life has ups and downs. Most of us experience both. Some get more of one than the other, but that's life. There are no guarantees. A good job may be great but there is no guarantee it will last.
Personally speaking, I've gone from financial security to barely making ends meet. I've had a house, cars, etc. Then the job disappeared, and it took everything I loved and worked so hard for right along with it. There just are no guarantees things will stay the same. The good news is that they can change for the better too!
I now live in a tiny apartment, my computer is my luxury, my world, my connection to most things and wonderful people. I have no car; I rent on a bus line and use the bus and my feet for all my transportation. I live in a city where I can do that.
Your aged father having to worry about your financial situation is unfair. The best thing you can do for him is to make things happen for yourself. Find a nice room or efficiency apartment you can afford; get rid of the car if you can and save the car payment and insurance money. Live without frills. Find your own cheap thrills: library books, second-hand clothes and household items, etc. Make it a fun project to see just how cheaply you can live. It gets to be fun to see that life can be simple and cheap. It's amazing how you can be happy with "good enough" as opposed to 'the best'.
You can give your Dad the gift of him not having to worry about you by becoming more independent. It will be a gift to you too!
God grant me the serenity to accept the things I cannot change; courage to change the things I can;and wisdom to know the difference.


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Valassis Revenues drop 5.3%
Monday, February 23, 2009
Press release from the issuing companyLIVONIA, Mich. -- Valassis today announced financial results for the fourth quarter and full-year ended Dec. 31, 2008. We reported quarterly revenue of $626.3 million, down 5.3% from $661.5 million for the prior year quarter due primarily to the impact of the continued uncertainty in the global macroeconomic environment. For the fourth quarter of 2008, adjusted EBITDA* was $62.6 million, down from adjusted EBITDA* of $78.5 million for the prior year quarter. During the fourth quarter of 2008, we reported a $245.7 million pre-tax, non-cash impairment charge related to goodwill and other intangible assets that resulted in a quarterly net loss of $222.0 million, or $4.63 per share, compared to net earnings of $20.6 million, or $0.43 per share, in the prior year quarter. Without the impairment charge, net earnings for the quarter would have been $1.4 million or $0.03 per share.
Full-year 2008 revenue was $2,381.9 million, up 6.2% from reported full- year 2007 revenue of $2,242.2 million (which excludes revenue for ADVO, Inc. for the period of Jan. 1, 2007 through March 1, 2007). Full-year 2008 revenue decreased 3.4% compared to pro forma revenue for full-year 2007 of $2,465.7 million. Full-year 2008 adjusted EBITDA* was $216.8 million, as compared to full-year 2007 adjusted EBITDA* of $252.8 million. With the aforementioned impairment charge, full-year 2008 net loss was $207.5 million, or $4.32 per share, as compared to full-year 2007 net earnings of $58.0 million. Net earnings for the year would have been $15.9 million, or $0.33 per share without this charge.
"As the prolonged economic downturn continues to constrict client advertising budgets, we remain focused on what we can control - our strategy, execution and costs," said Alan F. Schultz, Valassis Chairman, President and Chief Executive Officer. "A number of our products are well positioned in this recessionary environment, as they deliver value to a growing list of today's deal-seeking consumers."
Some additional financial highlights include:
-- Achieved 2008 Cost Synergies: Total 2008 cost synergies resulting from our acquisition of ADVO, Inc., were $38.4 million compared to our target of $38.0 million.
-- Reduction of SG&A Costs: Fourth-quarter 2008 SG&A costs were $97.9 million, which includes $2.5 million in legal costs related to the News America lawsuit and $4.2 million in severance costs, compared to the prior year quarter SG&A costs of $107.1 million which included $7.6 million in non- recurring charges. This 8.6% reduction was due primarily to decreases in incentive-based compensation, discretionary spending and staffing.
-- Reduction of Capital Expenditures: Capital expenditures for the fourth quarter of 2008 were $5.3 million. Full-year 2008 capital expenditures were $24.7 million, well below our full-year 2008 guidance of $35.0 million.
-- Liquidity: During 2008 we generated $96.3 million in Cash Flow from Operations and had a net decrease in debt of $108.0 million. We subsequently paid off and cancelled our 6 5/8% Senior Secured Notes that matured on Jan. 15, 2009. No other material debt maturities are scheduled until 2014. We announced on Jan. 26, 2009, that we amended our senior secured credit facility to, among other things, permit us to use up to $125 million to repurchase from tendering lenders our outstanding term loans at prices below par through one or more "modified Dutch" auctions during 2009. In addition, we also agreed to voluntarily reduce the availability on our revolving credit portion of the senior secured credit facility from $120 million to $100 million. The amendment also permits us to exclude from the definition of Consolidated Interest Expense swap breakage costs in connection with any repurchases or payments on outstanding term loans.
-- Pre-Tax, Non-Cash, Impairment Charge: In accordance with SFAS No. 142, "Goodwill and Other Intangible Assets," we recorded a pre-tax, non-cash, impairment charge of $245.7 million. The charge represents a decrease in the market value of our business and does not affect our cash flow or day-to-day operations. In addition, we recorded a write-down of $4.8 million related to our investment in China.
Management noted that it continues to see declines in client marketing budgets due to adverse economic conditions. Based on current forecasts, we reiterate our guidance announced on Nov. 6, 2008: we assume a mid-single digit decline in revenue in the first half of 2009 and flat to slightly down revenue in the second half of 2009, which should result in 2009 adjusted EBITDA* of approximately $215.0 million and allow us to meet our covenant requirements throughout 2009.
"Our 2009 Profit Maximization Plan is on track to reach its total cost savings goal of $50 to $60 million for 2009," said Robert L. Recchia, Valassis Executive Vice President and Chief Financial Officer. "We are quickly adapting to the changing economic environment and doing the right things to control costs, minimize risk and maintain a strong balance sheet and cash flow."
Business Segment Discussion
-- Shared Mail: Revenue for the fourth quarter of 2008 was $337.1 million, down 11.0% compared to the prior year revenue for the quarter. The decline was due to reduced spending in the mass merchandising vertical, lightweighting by grocery retailers and lower wrap revenue. Segment profit for the quarter was $22.8 million compared to $34.4 million for the prior year quarter. Full-year 2008 segment revenue was $1,370.8 million compared to pro forma full-year 2007 segment revenue of $1,406.9 million. Full-year 2008 segment profit was $89.8 million.
-- Neighborhood Targeted Products: Revenue for the fourth quarter of 2008 was $153.8 million, up 8.0% compared to the prior year quarter revenue of $142.4 million, due primarily to an increase in spend in the financial, insurance and telecom verticals. Segment profit for the quarter was $11.0 million compared to $16.1 million for the prior year quarter. Segment profit declines for the quarter were due primarily to a shift in product mix. Full- year 2008 segment revenue was $469.2 million, down 2.4% from full-year 2007. Full-year 2008 segment profit was $38.8 million, down 36.7% from full-year 2007.
-- Market Delivered Free-standing Inserts (FSI): Revenue for the fourth quarter of 2008 was $91.5 million, up 1.4% compared to the prior year quarter due to an increase in industry unit volume of 5.2%. FSI cost of goods sold was up for the quarter on a cost per thousand (CPM) basis as a result of higher paper prices. Segment profit for the quarter was $2.0 million compared to $1.2 million for the prior year quarter. Full-year 2008 segment revenue was $370.2 million, down 7.7% from full-year 2007 due primarily to a mid-single digit price decline. Full-year 2008 segment profit was $1.8 million, down 91.3% from full-year 2007.
-- International, Digital Media & Services: Revenue for the fourth quarter was $43.9 million, down 12.5% compared to the prior year quarter due primarily to our sale of the French and one-to-one direct mail services businesses and the discontinuance of media business in other European countries. Without these businesses, revenue for the quarter would have been $41.8 million compared to $39.1 million in the prior year quarter, an increase of 6.9%. Segment profit for the quarter was $3.8 million, including restructuring charges of $0.6 million, compared to a loss of $2.4 million for the prior year quarter which included restructuring charges of $7.6 million. Full-year 2008 segment revenue was $171.7 million, down 1.7% from full-year 2007. Without the discontinued businesses previously discussed, revenue would have been $147.1 million for 2008 compared to $142.6 million in full-year 2007, an increase of 3.2%. Segment profit for the full-year 2008 was $0.6 million and included restructuring charges of $2.5 million, down 77.8% from full-year 2007, due primarily to continued investment in our interactive initiative.
Industry News
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WikipediaRead full entry
Barred antshrike
The barred antshrike (Thamnophilus doliatus) is a passerine bird in the antbird family. It is found in the Neotropics from Tamaulipas, Mexico, through Central America, Trinidad and Tobago, and a large part of South America east of the Andes as far south as northern Argentina, Bolivia and Paraguay. There is one accepted record from southern Texas.[2] It is found in a wide range of wooded habitats (even gardens and parks) in both humid and arid regions. Throughout a large part of its range, it is among the most common antbirds.
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The barred antshrike is typically 16.5 cm (6.5 in) long, and weighs 25 g (0.88 oz). This species exhibits marked sexual dimorphism. The male is barred all over with black and white, and has a white-based black crest that is raised in display. The female is rufous above with a chestnut crest. The sides of her head and neck are streaked with black, and the underparts are rich buff. In both sexes, the legs are grey, the bill is black and the iris is pale yellow.
The subspecies vary primarily in the overall darkness and the amount of barring and hue of the underparts. For example, in the Tobagonian race T. d. tobagensis, males are whiter below, and females darker, than in the nominate subspecies. The most distinctive subspecies is T. d. capistratus of the Caatinga in north-eastern Brazil, where males have uniform black crown (no white barring to the base) and females have streaked throat and faintly barred belly. It is also the only subspecies where the iris is deep maroon-red. It has recently been suggested that it should be considered a separate species, the Caatinga barred antshrike.
It is typically found as territorial pairs. The female lays two purple-marked creamy white eggs in a deep cup nest in a shrub, which are incubated by both sexes for 14 days to hatching. The chicks fledge in another 12–13 days.
The barred antshrike is an insectivore which feeds on ants and other arthropods at or near the ground; it sometimes follows columns of army ants, and will take small lizards and berries. It is a skulking species, which may be located by its chuckling hu-hu-hu-hu-hu-hu song, often performed as a duet by a pair of birds, or a growled graaaaa.
- ^ BirdLife International (2012). "Thamnophilus doliatus". IUCN Red List of Threatened Species. Version 2013.2. International Union for Conservation of Nature. Retrieved 26 November 2013.
- ^ Lockwood, Mark W. (December 2007). "Texas Bird Records Committee Report for 2007". The Texas Bird Records Committee.
- ffrench, Richard (1991). A Guide to the Birds of Trinidad and Tobago (2nd ed.). Comstock Publishing. ISBN 0-8014-9792-2.
- Hilty, Steven L (2003). Birds of Venezuela. London: Christopher Helm. ISBN 0-7136-6418-5.
- Assis, C.P.; Raposo, M.A.; Stopiglia, R.; Parrini, R. (2007). "Validation of Thamnophilus capistratus Lesson, 1840 (Passeriformes, Thamnophilidae)". The Auk 124 (2): 665–676. doi:10.1642/0004-8038(2007)124[665:VOTCLP]2.0.CO;2.


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Women have internal sex organs, men have external sex organs. Men produce their sperm in the testicles. Sperm is sensitive to temperature and will die if it gets too warm or too cold. So a man swimming in cold water will kill the sperm in his testicles. Normally, this is not a problem because men are producing new sperm all the time, but, if the man is a professional breath-holding diver and is immersed in cold water every day, then he will be continuously killing his sperm and will be unlikely to father children. Another problem for men, is that if they spend too long in very cold water they can suffer frostbite on their penis, which is something no man would want to experience.
Dr Bookspan working as a Ama diver
Dr Bookspan spent time working as an Ama diver to study the effects of swimming in cold water on her own body and the bodies of Ama divers. The divers she studied were all wearing cotton costumes. She made the point that these costumes were very uncomfortable when wet and would make the Ama divers feel much colder when out of the water than if they wore nothing. A naked body will soon dry through its own body heat, but wet clothing will keep the body wet, take far longer to dry and will feel very cold in the slightest wind.
In the past the Ama divers wore nothing, however after the Second World War, with the increase in tourism, too many outsiders began to comment on their nakedness, Ama divers were forced to do a cover-up and adopted cotton costumes. Dr Boodspan says, -
"Diving clothes varied by geographic area, with some divers wearing only a rope belt or loincloth. No fins were used to help swimming. Later when wet suits were developed, only male divers wore them. Women were prohibited protective suits by their cooperatives, since they were considered more cold tolerant to begin with, and the advantage of the suit would "accelerate over-harvesting" Later, the work became pretty much exclusive to women."
She also explains that wet-suits are not as large a benefit for women as they are for men, in cold water. This is because men have a higher skin temperature than women and therefore more heat is radiated away from a man's body in cold water, than from a woman's. So the insulating qualities of a wetsuit are less use to women.
So if this is the reason why few men are breath holding divers in
So how was she able to accomplish these feats when a normal person would quickly freeze to death? It seems that open water swimmer not only train themselves to swim for long distances but also train their bodies to withstand very cold water. This is commonplace with swimmers who have swam the
In 1976 Lynne Cox became, officially, the first person to swim across the
Bounty hunters killing the Yamana and Ona people.
Drawing of Tasmanian Breath divers
There have been reports of breath-holding divers all over the world. In South East Asia reports come from places like
Giant Statue of Mermaid on Kollam Beach, India
There were breath-holding divers in both North and
Large Shell mound before it was bulldozed in the 1920s
So this is the reason why we mostly have stories of mermaid and not mermen, because women can endure cold water much better than men. In our next video we will explain why in so many stories of mermaids in


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A Randomized, Double-Blind Study of MKC-442 Combined With Viracept in Patients Who Are Epivir + Retrovir Experienced and Are Protease Inhibitor- and Non-Nucleoside Reverse Transcriptase Inhibitor-Naive
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00002215
Recruitment Status : Completed
First Posted : August 31, 2001
Last Update Posted : June 24, 2005
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|HIV Infections
|Drug: Emivirine Drug: Nelfinavir mesylate
|Not Applicable
In this randomized, placebo-controlled study, patients are allowed to switch at entry to d4T plus 3TC or d4T plus ddI based on investigator and patient preference. Patients are stratified based on the number of nucleoside reverse transcriptase inhibitor (NRTI) treatments that are changed at entry and on screening HIV-1 RNA (obtained within 30 days of entry) as follows: switched 1 NRTI and 10,000-50,000 copies/ml vs switched 1 NRTI and greater than 50,000 copies/ml vs switched 2 NRTIs and 10,000-50,000 copies/ml vs switched 2 NRTIs and greater than 50,000 copies/ml. Patients are randomized within each of these strata to 1 of the following treatment arms:
Arm 1: MKC-442 placebo plus nelfinavir. Arm 2: MKC-442 plus nelfinavir. Arm 3: MKC-442 plus nelfinavir (higher dose). Treatment is administered for 48 weeks. Patients who are considered virologic successes at Week 48 may continue to receive MKC-442 at the discretion of the investigator.
|Study Type :
|Interventional (Clinical Trial)
|Primary Purpose:
|Official Title:
|A Randomized, Double-Blind Study of MKC-442 Combined With Viracept in Patients Who Are Epivir + Retrovir Experienced and Are Protease Inhibitor- and Non-Nucleoside Reverse Transcriptase Inhibitor-Naive
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria
Concurrent Medication:
At least 1 different nucleoside analog, e.g., 3TC, d4T, or ddI (excluding zidovudine).
- Chemoprophylaxis for Pneumocystis carinii pneumonia.
- Short courses (less than 21 days) of acyclovir for acute treatment.
- Recombinant erythropoietin or G-CSF for Grade 3 or greater anemia and neutropenia, respectively.
- Allowed only with caution and close patient monitoring:
- Ketoconazole, fluconazole, itraconazole, and grapefruit juice.
- Medications metabolized by cytochrome P450.
- Oral contraceptives, contraceptive implants such as Norplant, or injection-type contraceptives such as Depo-Provera only if not sole method of contraception.
Patients may have:
- HIV-1 RNA greater than 10,000.
- No active AIDS-defining illnesses.
- Prior experience with 2 nucleoside analogues and able to switch to at least 1 different non-nucleoside analog, e.g., lamivudine (3TC), stavudine (d4T), or didanosine (ddI) with HIV-1 RNA 10,000 copies/ml or less. [AS PER:
- Nucleoside analog-naive patients must have HIV-1 RNA greater than 50,000 copies/ml.].
Prior Medication:
Treatment with 2 nucleoside analogs. Note:
- able to switch to at least 1 different nucleoside analog e.g., lamivudine (3TC), stavudine (d4T), or didanosine (ddI), while on study [AS PER AMENDMENT 8/4/98].
Exclusion Criteria
Co-existing Condition:
Patients with any of the following symptoms or conditions are excluded:
- Active AIDS-defining illnesses.
- Malabsorption syndrome or severe chronic diarrhea within 30 days of entry, or inability to consume adequate oral intake due to chronic nausea, emesis, or abdominal or esophageal discomfort. [AS PER AMENDMENT 8/4/98].
- Inadequately controlled seizure disorder [AS PER AMENDMENT 8/4/98].
- Any intercurrent illness that could affect viral load determination [AS PER AMENDMENT 8/4/98].
Concurrent Medication:
- Zidovudine.
- Immunomodulators (e.g., systemic corticosteroids, interleukin-2, or interferons). [AS PER AMENDMENT 8/4/98].
- Rifampin, rifabutin, phenobarbital, and hydantoin.
- Amiodarone, quinidine, astemizole, terfenadine, ergot derivatives, midazolam, triazolam, and cisapride.
- Neurotoxic agents (e.g., vincristine, thalidomide). [AS PER AMENDMENT 8/4/98].
Patients with the following prior conditions are excluded:
- History of acute or chronic pancreatitis.
- History of > grade 2 peripheral neuropathy.
- Patients with an acute and clinically significant medical event within 30 days of screening.
Prior Medication:
- Protease inhibitors.
- Non-nucleoside reverse transcriptase inhibitors.
Excluded within 30 days of study drug administration:
- Immunomodulators (e.g., systemic corticosteroids, interleukin-2, or interferons). [AS PER AMENDMENT 8/4/98].
- Rifampin, rifabutin, phenobarbital, and hydantoin.
- Amiodarone, quinidine, astemizole, terfenadine, ergot derivatives, midazolam, triazolam, and cisapride.
- Immunotherapeutic vaccines.
- Cytotoxic chemotherapeutic agents [AS PER AMENDMENT 8/4/98].
Prior Treatment:
Excluded within 30 days of study drug administration:
Radiation therapy [AS PER AMENDMENT 8/4/98].
Risk Behavior:
Current alcohol or illicit drug use that, in the opinion of the investigator, may interfere with ability of patient to comply with dosing schedule and protocol evaluations.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00002215
|United States, Pennsylvania
|Anderson Clinical Research
|Pittsburgh, Pennsylvania, United States, 15213
|ClinicalTrials.gov Identifier:
|NCT00002215 History of Changes
|Other Study ID Numbers:
|First Posted:
|August 31, 2001 Key Record Dates
|Last Update Posted:
|June 24, 2005
|Last Verified:
|April 1999
Keywords provided by NIH AIDS Clinical Trials Information Service:
Drug Therapy, Combination
HIV Protease Inhibitors
RNA, Viral
Reverse Transcriptase Inhibitors
Viral Load
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Protease Inhibitors
HIV Protease Inhibitors
Reverse Transcriptase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Nucleic Acid Synthesis Inhibitors


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Balotelli racially abused during training
Mario Balotelli was subjected to racial insults while training for Italy at the Italian Football Association's (FIGC) training centre in Coverciano, near Florence, on Wednesday.
• Rzouki: Squad selection headache for Prandelli
The AC Milan forward did not respond or react to the insulting chants from one fan, who was identified and led away from the training centre. Most of the fans watching the 30-man Italy squad training showed their support for the 23-year-old, the FIGC reports on its website.
A statement from the FIGC read: "Some boys surrounding the field made some offensive chants towards Mario Balotelli and one of them pronounced a racial insult."
Although he was "distressed by the incident," Balotelli continued to train with his colleagues. According to La Gazzetta dello Sport, Balotelli said to his teammates: "It's incredible, these things happen only in Rome and Florence."
The president of the FIGC, Giancarlo Abete, condemned their actions. "It is absolutely unacceptable behaviour by individuals who should not exist, but sadly we have to accept they are there. The important thing is that they are a minority," he said at a meeting in Milan.
It is not the first time Balotelli has been victim of racially-motivated insults from Italian fans with opposition fans often targeting him in a bid to unsettle him and provoke a reaction.
Inter Milan were fined last year when their fans insulted their former player during a match in which Balotelli was not even playing.
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- Use your finger to move Fins through the ocean
- Guide Fins to the yellow markers to uncover fun animations
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New ADT chief executive Naren Gursahaney clearly likes the gee-whiz aspect of the security business he's leading.
In his new Boca Raton office, he demonstrates how he can monitor his Princeton, N.J., home from his laptop. He switches his porch lights on and off and takes a peak in the laundry room where the dog sleeps.
The Boca Raton-based company with 16,000 employees, 700 of whom work in South Florida, is banking on other homeowners wanting to do the same and upgrade their security systems.
"I have a passion for the business," said Gursahaney, 50, who will lead the $3.1 billion company splitting from parent Tyco International. Shareholders approved the separation, according to results released Monday.
Gursahaney, who was groomed by Tyco CEO Ed Breen, said he'll expand the company primarily through innovative new services, but will consider acquisitions that make "economic sense."
ADT already has the biggest share of the U.S. security market -- 25 percent share of the residential security market -- and about 15 percent of the small-business market. In revenue from security services, ADT is No. 1 among security firms with nearly 6.4 million subscribers and $3.1 billion in revenue as of 2011.
But there's plenty of room to grow, said Gursahaney, pointing to only 20 percent of consumers having a security system. "We have to earn our customers' trust. That means doing things better and anticipate what customers are going to be needing next," he said.