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Issam A. Awad, MD
John Harper Seeley Professor of Surgery
Director, Neurovascular Surgery
Director, Safadi Program of Excellence in Clinical and Translational Neuroscience
Issam A. Awad, MD, is an internationally recognized leader in neurosurgery. He is skilled in the surgical management of neurovascular conditions affecting the brain and spinal cord, including cerebral aneurysms, cerebrovascular malformations, carotid surgery, hemorrhagic stroke and skull base tumors.
Dr. Awad's research contributions have spanned more than two decades. His scientific innovations include the characterization of subcortical ischemic lesions in the aged, advances in the understanding of the natural history and biologic behavior of cerebral vascular malformations, and numerous technical advances in neurovascular and epilepsy surgery.
Recognized as a pioneering and productive scholar, Dr. Awad has educated scores of neurosurgeon trainees and holds prominent editorial responsibilities. He has authored leading textbooks and published more than 250 scholarly papers related to clinical innovations, surgical outcomes and research.
Additionally, Dr. Awad has been elected to some of the most distinguished professional societies and has held leadership positions in professional and learned societies in the United States and around the world. He has served as President of the Congress of Neurological Surgeons, Chairman of the Cerebrovascular Section of the American Association of Neurological Surgeons, Chairman of the Congress of Neurological Surgeons, and on the Executive Committee of the American Stroke Association and the Board of Governors of the American College of Surgeons. He is the Founding Chairman of the Scientific Advisory Board of Angioma Alliance. He has been recognized as one of the "Best Doctors in America" for more than a decade.
Practice Locations
The University of Chicago Medicine
Center for Advanced Medicine
Year Started Practice
Board Certification
Neurological Surgery
Medical School
Loma Linda University School of Medicine
Loma Linda University Medical Center, CA
Cleveland Clinic, OH
The Royal Infirmary of Edinburgh, Scotland, UK
Alpha Omega Alpha Honor Medical Society
Languages Spoken
Office Phone
(773) 702-2123
Office Fax
(773) 702-3518
Office Postal Address
Issam A. Awad, MD
Clinical Interests
Request an appointment online
Learn More About Dr. Awad
Dr. Awad is director of the Safadi Program of Excellence in Clinical and Translational Neuroscience.
Dr. Awad helps collegiate hockey player Sam Messina get back on the ice after surgery to repair his arteriovenous malformation.
As medical director of the University of Chicago Medicine's HHT program, Dr. Awad leads a multidisciplinary team that cares for patients with hereditary hemorrhagic telangiectasia (HHT).
Learn more about Dr. Awad's research.
Dr. Awad reunited with a grateful patient 27 years after he performed surgery on her following a stroke.
Dr. Awad's cerebral cavernous malformation (CCM) clinic attracts patients from around the world. Learn how he helped 4-year-old Zane Smith, whose family traveled from Cambridge, England to seek Dr. Awad's expertise.
Ohio resident Sherry Kedra sought out Dr. Awad after a cerebral cavernous malformation (CCM) leaked into her brain. When a second CCM bled a year later, Kedra returned to Chicago for surgery. Read Sherry's story.
Grateful for the successful treatment of a dural arteriovenous malformation/fistula (DAVM/DAVF) in his brain, Bill Davis and his wife Judy made a generous donation to support Dr. Awad's research. Read Bill's story.
After suffering a massive stroke, Jim Faulkner credits Dr. Awad's expert care for giving him a second chance at life. Read Jim's story.
Dr. Awad successfully detected and removed a cerebral cavernous malformation (CCM) that had been causing Steven Steinhilber to experience seizures. Read Steven's story.
In a four-hour procedure, Dr. Awad, who has performed more than 800 such surgeries in his 25-year career, treated multiple cerebral aneurysms in a single operation.
Read how Dr. Awad removed a large tumor, a large meningioma, from the base of a woman's brain, restoring her vision.
By performing an experimental procedure, Dr. Awad saved the life of a man who had experienced an intracerebral hemorrhage, a type of stroke.
A pill to prevent brain surgery? Dr. Awad and his colleagues are investigating a drug that may lower the risk for people with the familial form of CCM.
Selected Publications
View a partial list of Dr. Awad's publications through the National Library of Medicine's PubMed online database.


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- Signature pads
- Software
- Apps
- Solutions
- References
- Service
- About us
StepOver International GmbH delivers exclusively outside the EU. For deliveries inside EU, please select the language English-UK&Ireland. Do not show note
The duraSign Pad Brilliance is the first in the line of an entirely new product family - the "duraSign Pad Series" from StepOver Europe. This product series - and by extension this signature pad - stands out for its extreme durability, coupled with outstanding security features and an elegant appearance.
Thanks to its extremely flat structure (1.1 cm thick) and large colour screen, the naturaSign Pad Colour 2.0 signature pad doesn't just shine on the counter - it even copes brilliantly with the demands of mobile use. Plus, this device is the most advanced on the market in terms of security and technology.
Developed especially to meet the demands of mobile use. Thanks to its large black-and-white screen, rounded edges and ultra-flat structure (0.95 cm thick), this signature pad is a highly compact yet stable device for capturing signatures.
The signature pad naturaSign Pad Classic with black-and-white screen and USB connection is the official successor to the signature capture devices naturaSign Pad Standard I and II, which have sold one hundred thousand copies. At first glance, this signature pad does indeed resemble its predecessors, but the screen resolution has been heightened to better display both the graphics and the signature.

subset: commoncrawl


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Our school programs will have kids everywhere wanting more!
We've spent the last decade adding a pinch of magic to curriculums across Melbourne. Our programs not only bring a huge dose of fun to your school, they improve physical health, increase feelings of resilience and coping. With a focus on teaching perseverance, building confidence and self-esteem – they are an excellent component of your school's wellbeing program.
Do you want to get your school involved in the exciting world of the circus? Learn more about each program by clicking on the relevant button below.
Performing Arts
Give your students the opportunity to explore a different type of performance. Our circus shows give kids a unique experience, allowing them to find new talents – both as individuals and working together in a team.
With music, costumes and the whole creative process taken care of by us, what are you waiting for?!
Circus Show-Off (day performance)
If you want to offer your school students that little bit extra, then the Circus Show-Off program gives them all of the above and more.
As well as taking the children step-by-step through the basics of all age-appropriate circus skills, our experienced trainers will help them to focus on more specific routines and equipment to prepare for a daytime circus display they can put on for their parents or fellow students.
Evening concert
We know that organising a performance is difficult – it takes time, energy and lots of patience (and that isn't made any easier when you're trying to run a school at the same time!).
But as a team of seasoned experts, Little Devils Circus makes stress a thing of the past; we don't just help your school deliver a mind-blowing performance… we do all the hard work. Everything is provided – the music, the costumes, the equipment, the rehearsals – all you have to supply is the children!
And when you read the outstanding parent feedback, it's no wonder this program is our most popular service for schools.
If you want to give your school's children, parents and staff a performance they'll remember with pride for the rest of their lives, then call us now on 1300 JUGGLE (1300 584 453) or get in touch here.
Please be advised that our availability for the school concert program gets snapped up fast, so the sooner you contact us the better.
"It was an absolutely wonderful experience for the students, parents and staff. One we will never forget.It was so rewarding to watch the students' efforts along with their broad smiles. They were so, so proud of their achievements and accomplishments!. The performance was well timed, choreographed, glittering costumes and disciplined. The students knew what to do and it was wonderful to see the continued support offered by the trainers throughout the show. The night was a huge success, and I knew that it would be well received and appreciated by everyone once they saw the finished product."
Gayle Cope, Principal, Wattle Park Primary School
"This week at our Transition program for the new prep students who are to join our school next year, there was a little fellow who was reluctant and reticent. One of our year 5 students- Juan pulled out three of his own juggling balls and proceeded to entertain him and bring a smile to that little ones face! So the skills will live on – not just for a one off school performance."
Gayle Cope, Principal, Wattle Park Primary School
"As the Performing Arts Co-ordinator, I was extremely happy with the way Little Devils worked in with the school. Our communication was clear and the concert ran smoothly with fantastic parent feedback. Our best Concert Ever. Thank You!"
Kingswood Primary School
"The parents were astounded and blown away! They were particularly impressed that all the children were "stars" and they all had the opportunity to shine."
Julie Wilkinson, Principal, Solway Primary School
"Thanks for the whole Little Devils experience. The trainer was FANTASTIC and had great rapport with the students. They were very skilled in their teaching throughout, extremely well organised, and we would love to do it all again next year!"
Sandringham Primary School


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This item is so popular, it has sold out. You're in luck! It'll be back soon. Please enter your email and we'll notify you as soon as it returns.
These colorful, handpainted teapots are made in Morocco from recycled glass.
While these are heatproof, some caution with very hot liquids is advised.
Capacity: 32 oz.
Product is final sale and not returnable


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It has been a very busy month. I've spent many hours on an animation piece for a great local play called The Jade City Chronicles. If you haven't heard of it, you will. This thing is going to be big!
On top of that, I was in Atlanta for a week participating in the Portrait Society of America's Art of the Portrait conference. I made some amazing contacts and learned a lot, most of which I'm trying to implement daily.
The show that opened at the Main Street Gallery in Carrboro is a hit. The turnout opening night was better than expected and I look forward to selling a few pieces from the show. But wait, there's more!
As you know, I'm starting to do some work on the Christmas triptych (see last entry) as well as a series of Tarot paintings. The Tarot will concentrate on the 22 Major Arcana and I've already started recruiting models to pose. If any of you have ever wanted to be in your own tarot deck, now's the time! For that matter, if you've ever wanted to be a maid-a-milking, now is also THAT time.
The new Passion Paintings seem to be doing some great things for people (and here I do not make fun, because I think these may actually be some of the most important paintings I have ever done).
And I've decided which charity I'm going to support this year. I will make a bigger announcement about that. But, for you insiders you will get to know ahead of the rest of the pack. This year, 10% of every painting sold will go to the Alzheimer's Foundation of America (http://www.alzfdn.org/). The Alzheimer's Foundation of America is a great organization. According to the website: "85% of expenses go directly to programs and services to help individuals with Alzheimer's disease and their caregivers; the remaining 15% of expenses support administrative and fundraising events."
There will be more links for that coming soon, including their financial report, recognition, etc. And this one is close to my heart, so we'll be doing all we can to help!
On top of all that, I'm planning for my next big art show, sometime in September of this year. I'll be sure to announce the date as soon as I firm it up.
As you can see, I have a very busy year ahead of me. The good news is that I don't have to do it alone. You guys have been amazing! I love hearing your comments and assistance. Without you I couldn't do this, so thank you VERY much.
I have a lot to do, and you have a lot to look forward to from Seraphim Studios.
--- Geraud


text: I've been dying for a sig p229ST forever now and when it FINALLY got released, ordnance outsellers wouldn't send it because our DOJ hadn't approved it yet. So I let my dream drift away for a few months until I realized I can hard chrome/nickel finish a regular p229 to look like the ST. Now I can finish the p229 but I want the p229 rail in .40 w/ satin/nickel/chrome but it seems like the DOJ only leaves me with the p229 rail in 9mm or the p229 w/o rail .40. Why can't I have the p229 rail .40!?!?!?!?


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Werner Horvath
Werner Horvath was born in Linz, Austria in 1949 and has been painting since his youth. Beside this interest he studied medicine in Vienna and is now a well known chief radiologist in Linz, specialist in interventional radiology. His art-style turned from Phantasic Realism (1969 - 1975) slowly to New Constructivism, named after the philosophical theory, based on the works of Vico, Uexküll, Glasersfeld, Watzlawick and others. The theoretical background is explained in detail by the artist in a stage play in form of a text-collage, called Jahrtausendwende - Die Theorie des neuen bildenden Konstruktivismus (in German). Horvath tries to show in his paintings, that the so-called reality is not so "real" at all, for the world we live in can be understood as constructed by ourselves. For instance, colors do not really exist, but are products of the visual system and therefore are only "real" within our consciousness. But also forms of all kind have no reality outside our subjective world; on the contrary they are built up by several psychological mechanisms. And at last we have to take into consideration, that we live in a "symbolic world": We see Stalin not only as a politician who lived from 1879 to 1953, but also as a symbol of dictatorship and cruelty. As precursors of his style Horvath names Giuseppe Arcimboldo and M.C.Escher. Most of Horvath's paintings are influenced by political events, deal with political and social problems or express the artist's opinion on our society.
|Albert Einstein
|Marilyn Monroe


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Payment options on www.flyuia.com and at UIA ticket offices
You can purchase your ticket using the following bank cards: Visa, Visa Electron, MasterCard, American Express, Diners Club International, Discover, UATP, Maestro UK, and Maestro International (excluding Ukraine)
Please note.
* In case of transaction via Ukrainian acquirer, payment is made in UAH. Please contact your card-issuing bank for detailed information about conversion and debiting an account.
* Payments under non-Ukrainian payment cards shall be managed by Ukraine International Airlines under the agreement governed by Dutch law and made by the Head of UIA's representative office in the Netherlands with the Adyen B.V., or by other payment solutions contracted by Ukraine International Airlines, with the application of the relevant intraregional / interregional fees.
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You can pay for your ticket using the link sent to you by out Contact Center agent via e-mail.
Please note. In order to have your ticket issued in time, it is mandatory that you immediately contact UIA and confirm successful payment as well as acknowledge the receipt of the ticket. Otherwise your booking may be cancelled.
You can check the receipt of payment into the UIA account in UIA Contact Center using the following online form.
Payment options on www.flyuia.com
Ticket booked on www.flyuia.com can be paid via bank transfer within Ukraine only.
Information regarding the total amount and payment deadline will appear, and you will receive an email with your Booking Confirmation as well as a Payment Order attached which must be paid within 48 hours. Your e-ticket will be issued automatically upon receiving payment into the UIA current account, and a "Confirmation" with your ticket number will be sent to your e-mail address.
Please note: This payment method may be used no later than 7 days prior to scheduled flights departure. Should you need originals of a tax invoice and a delivery note, you may receive them in our ticket offices. Legal entities must present a power of attorney.
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Prior to paying for your ticket via bank transfer, please make a booking through our call centre. After the booking has been made, you will receive an invoice via e-mail.
Note. Should you need originals of a tax invoice and a delivery note, you may receive them in our ticket offices. Legal entities must present a power of attorney.
You can check the receipt of payment into the UIA account in UIA Contact Center using the following online form.
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Ticket can be booked on www.flyuia.com and paid at particular UIA ticket offices in:
Payment must be made within 48 hours otherwise your reservation will be automatically cancelled. Such payment method may be used no later than 5 days before your flight departure.
Please note the following service fees are applicable:
Detailed information on UIA service fees can be found here.
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UIA knows that credit and debit card security is important. To ensure that your online transactions on the UIA official website are secure, we partner with industry-leading and reliable online payment providers. When paying for air tickets online, our passengers enter payment card data on a secure page of our acquiring bank partner which uses 3D-Secure technology for safe online shopping. The card processing system is in full compliance with PCI DSS (Payment Card Industry Data Security Standard) international security requirements.
Payment options on www.flyuia.com
EasyPay terminals at Chernivtsi, Kherson, Vinnytsia, Zaporizhzhia airports
Additional services can be paid via EasyPay terminals at Chernivtsi, Kherson, Vinnytsia, and Zaporizhzhia airports. Currency: only UAH is accepted.
The following services can be paid:


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Carrefour Spain has joined the green movement with a campaign that equates plastic bags to excrement. The concept is straightforward, simple and easy to remember: "Plastic bags = shit."
It's the first supermarket in Spain to join the ecological movement. The campaign, created by Publicis Madrid, surprised the audience by using an unexpected tone, deeply different from the one brands usually use when referring to these delicate matters. Publicis' chief creative officer, Santiago Lucero, explained that they decided to "simply say plastic bags are shit, just like you tell your kids when you want them not to touch something toxic or dangerous."
The first part of the campaign consisted of a four-day period of teaser spots, with an anonymous message reading: "Plastic bags take 400 years to decompose. Shit = bags. 400 years. 400 shits. We must do something." The films invited the audience to visit a website called Give the Environment a Hand.
Later, they aired other commercials showing the Carrefour logo and phrases such as "A 15-minute use and 400 years to decompose. It's just not worth it."
The supermarket also suggested replacing plastic bags with a different kind of material, such as raffia, cotton or biodegradable starching.
Carrefour is heading down a path that will soon become the only choice for stores and supermarkets. Last year, the Spanish government approved the Plan Nacional Integrado de Residuos, or National Integrated Plan of Waste Materials, a set of rules aimed to restrict and eventually ban the use of plastic bags by 2015. Spain is the third-largest consumer of plastic bags in Europe. Spaniards uses an average of 238 bags per year and supermarkets are a big provider. Only 10% of the bags are recycled.
Spain hasn't been the only country to take up the issue. There were at least two anti-bag campaigns in Latin America, only they use a different approach and a much softer tone. Last March, Argentine agency Kepel & Mata made a spot called "Revenge" for Chilean Cencosud Group, owner of Jumbo, Disco and Vea. They went for an emotional tone, using a 3-D animated story.
Last month, the Brazilian Social-Environmental Plastic Institute invested almost $4 million on an integrated campaign created by Washington Olivetto's W/ agency, focused on the "three Rs concept": Reduce, Reuse and Recycle. Seventy percent of the Brazilian population prefers plastic bags, and instead of forbidding them, they chose to educate people in order to get them to behave responsibly.
The government implemented a program that, among other measures, includes the promotion of a more-resistant kind of bag that will stop people from using two bags instead of one to carry heavy stuff and will still be durable enough to be used again at home.


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900 TreadmillTRUE Fitness prides itself on manufacturing the world's highest quality cardio equipment to fit every facility and every budget. The 900 is the embodiment of that philosophy.
Performance 100 TreadmillThe TRUE Performance 100 treadmill offers affordable quality for your home fitness needs.
Performance 300 TreadmillTRUE Performance 300 is a treadmill suited for users of all fitness levels. It is simple to monitor your progress on the Performance 300 with the easy-to-read LCD screen.
Performance 800 TreadmillThe TRUE Performance 800 offers a customizable experience on one of the largest running surfaces in the industry. Up to 6 users can save their own custom profile information that can be easily accessed by tabs seen at the bottom of the console.
30 TreadmillThe new 30 treadmill was made from the user foremost in the mind. This new streamlined, compact footprint is manufactured with only optimum components and is sure to rival any merchandise in its category. Only TRUE puts the excess finishing touches into just about every individual product, and the 30 's no exception to this rule. In REAL tradition, the 30 gives a softer deck cushion in front where foot impact develops, while providing dependably firm foot push off to your back.
50 TreadmillThe new M50 treadmill was designed with the user foremost in mind. Featuring TRUE's orthopedic belt and aluminum straddle covers, the M50 stands apart from the rest. Only TRUE puts the extra finishing touches into each and every product, and the M50 is no exception to this rule. In TRUE Tradition, the M50 treadmill provides a softer deck cushion in front where foot impact takes place, while providing dependably firm foot push off towards the back. With an overall length of just 74", the M50 treadmll maximizes workout space in your home. TRUE encourages you to "Find Your Motivation" with the new M50.
5.0 TreadmillThe 5 fitness treadmill machine meets TRUE's uncompromising measures for quality using a walk-through frame that enables full use within the 5's running surface, but keeps the footprint small to increase your space. Modern, intelligent design complements an area instead of choosing it over.
5.4 TreadmillThe 5.4 treadmill meets the true standard for quality which includes a walk-through frame allowing full use with the 5.4's going surface, but keeps the footprint small to maximize your space. Modern, intelligent design complements a room instead of using it over. Walk/run and pace quick keys offer fast and simple access to exercise options.
Alpine Runner - Transcend 16The TRUE Alpine Runner is the ultimate combination of a traditional treadmill workout and the high intensity workout achieved with an average incline trainer.
Alpine Runner - Escalate 15The TRUE Alpine Runner is the ultimate combination of a traditional treadmill workout and the high intensity workout achieved with an average incline trainer.


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free icons
Make Your Artwork Smoother With ArtIcons 4.10
New Version of Award-Winning Icon Editor Offers Enhanced Image Processing Features
October 2004
- Aha-Soft, a leading developer of graphics software has announced this month a release of its award-winning icon creation and management tool Aha-Soft ArtIcons Pro v4.10. This innovative solution offers both professional and casual graphic artists all tools needed for designing, editing and retouching Windows icons and managing icon libraries.
The main stress in version 4.10 of Aha-Soft ArtIcons Pro is laid on perfecting image processing capabilities that allow creation of more attractively looking icons. Now graphic artists can apply anti-aliasing while importing and resizing images to smooth out their edges and eliminate artifacts commonly known as "juggies". Another new feature is the perspective grid that helps artists better use perspective in the process of creating the Windows XP style icons.
The image editor in the new version has also sufficiently improved from the days of the 3.xx versions and offers graphic artists a number of breakthrough features, including the ability to create icons with several raster layers. The support for multi-layer icons is implemented through the use of a new image format — Icon Project. "The concept of using layers is very familiar to any artist working with digital imaging software," — says a representative from Aha-Soft. — "Layers give you more freedom in using complex graphic tools and creating professionally looking images. This new feature enables Aha-Soft ArtIcons Pro to rival any high-end graphics package. In fact, it is better than any of these high-end tools when you consider creation of icons and other small graphics."
Aha-Soft ArtIcons Pro is specifically designed for efficient icon creation and management and offers a variety of features that cannot be found in standard graphics applications, including the ability to import icons from executables, image and library files and the search and extract function that enables busy artists scan through the contents of a folder or a drive and arrange all images found in any files into a single icon library for easy and effective management.
ArtIcons is equipped with all essential drawing tools including various kinds of airbrushes, pencils and paintbrushes as well as miscellaneous text, line and shape tools. The software also offers a variety of solid, patterned and gradient flood fills, drop shadow, smooth, color modification and other effects. The native Windows XP icon format support enables artists to create 32-bit icons with 8-bit alpha channels.
Aha-Soft Art-Icons Pro now supports multiple interface languages and images as large as 3000 by 3000 pixels. It features the ability to export icon libraries to single 32-bit bitmap images, new flood fill patterns and effects, and more.
System Requirements
Windows 95/98/ME/2000/NT/XP, 2MB of free disk space.
Shareware, 30 days trial. Standard version is $19.95 US, ArtIcons Pro is $39.95 US.
About the Publisher
Based in Krasnoyarsk, Russia, Aha-Soft manufactures cutting-edge image processing software for professional and amateur graphic artists. Aha-Soft's line of icon and cursor tools features innovative software designs to set new standards. This privately owned company was founded in 2000 and is off to a phenomenal start, receiving high praise in its first years of operation from top Internet download sites including ZDNet, TuCows and Simply the Best.
For more information about Aha-Soft please visit the company's web site at
P.O. BOX 17077, Krasnoyarsk-10, 660010, Russia
Full Version Evaluation
Should you need a full version for review, please email us at
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Perfect Toolbar Icons
Business Toolbar Icons
is our pick. It allows you to design and edit all kinds of graphics required in the software development cycle, including icons, static and animated cursors and interface elements - all these graphics can now be designed in a single application.
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Toolbar Icon Set
. A collection of practical and eye catching Windows icons representing all basic operations required for software development.
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Business Icon Set
will make your software and web products look more modern and attractive. File formats included into the set are Windows icons, GIF and PNG images.
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ArtIcons Pro
is an advanced icon-specific utility for Windows. It supports ICO, BMP, PNG, GIF, PSD, XPM, XBM, WBMP, CUR and ANI image formats and allows you to manage icon libraries.
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Any to Icon
converts icons and cursors into BMP, JPG, PNG, GIF, ICO, CUR and other formats. This wizard can find icons and make images for use on Web pages.
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oa Civil Engineer in South Africa - The upgrading of Black residential areas : Kwazakhele Township : Basil Read awards
In mid-1982, Mr Louis Rive, the man responsible for the upgrading of Soweto, was appointed to find ways of improving the quality of life in Black townships in the Eastern Cape. This involved sophisticated new township development and the improvement and extension of the basic infrastructure of the existing townships, including roads and stormwater, water and sewage reticulation, the installation of domestic sewage services, the supply of water and the provision of taps in each house.
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text: Inspired a passion for travel and the exotic climes of her own diverse background, Nicole Farhi's collections are renowned for their impeccable balance of creativity and class. After moving to London from France, Farhi began working with Stephen Marks at French Connection, before going on to create her own brand of women's fashion in 1982. The Nicole Farhi jacket collection is simply sublime. Combining decadent fabrics, impeccable tailoring and that all important sense of individuality, each piece is a study in modern sophistication.


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ISTANBUL, Turkey—Al Jefferson had 11 points and 17 rebounds, fellow newcomer Ryan Gomes scored 12 points as the Minnesota Timberwolves beat Efes Pilsen 84-81 Saturday in the first game of the NBA Europe Live tour.
Gomes had 10 points and nine rebounds in the first half. Ricky Davis scored 12 points.
Drew Nicholas scored 24 points, and Andre Hutson had 15 points and 19 rebounds for the Turkish team.
The Timberwolves spent the past week training in Istanbul as part of the Europe Live tour, helping dedicate a new basketball court and community center at a local school. They also distributed hearing aids to more than 1,000 children.
The Timberwolves traded longtime star Kevin Garnett, the NBA's leading rebounder each of the previous four seasons, to the Boston Celtics during the offseason. Jefferson and Gomes were two of the five players Minnesota got back in the deal.
The Timberwolves play the Celtics next week in London.


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Sensing McConnell could be defeated, challengers try to unseat veteran Republican leader
Emboldened by the far-ranging criticism of Kentucky Sen. Mitch McConnell as he tries to lead Republicans in a Democrat-controlled Senate, candidates from both parties are challenging the Senate minority leader's 2014 reelection bid.
Among the most recent to join the race are Republican candidate Matt Bevin, a Kentucky businessman and political newcomer, and Democratic challenger Alison Lundergan Grimes, Kentucky's secretary of state.
Much of the criticism about McConnell comes from the extremes of both parties.
The argument that McConnell continuously tries to maneuver and block Obama and the Senate majority's legislative agenda comes mostly from the more liberal faction of the Democratic Party, who also point to his 2010 comment that making President Obama a "one-term president" should be Republicans' top priority.
However, the conservative wing of his Republican Party has also been critical, saying McConnell has cast aside their core values in compromising with Democrats on such key issues as immigration reform, confirming Obama appointees and raising the federal debt limit.
Such concerns have resulted in Bevin endorsements from conservative groups including the Madison Project and the United Kentucky Tea Party, a coalition of 14 like-mined organizations.
The three squared off Saturday at the state's premiere political showdown, known as the Fancy Farm picnic.
McConnell largely ignored his challengers, aiming his criticism instead at President Obama while touting his leadership role.
Grimes and Bevin went on the attack, in the first joint appearance by the three.
Grimes tried to portray McConnell as the chief Republican obstructionist.
"If doctors told Sen. McConnell he has a kidney stone, he'd refuse to pass it," she said.
Bevin declared that he would defeat McConnell in the May 2014 primary. By the time he made the bold declaration, McConnell had left the stage.
The Madison Project said earlier this month in endorsing Bevin: "For years, Sen. McConnell has been undermining conservatives in the Senate, even as he evinces the image of a conservative warrior to his constituents,"
The endorsement by the fundraising group is expected to give Bevin access to donors across the country, which he will need considering McConnell's $10 million war chest that he uses to help club essentially anybody who even hints at a challenge.
His campaign, for example, posted an attack ad last week within hours of Bevin officially declaring his candidacy that accuses him of being a tax deadbeat and taking $200,000 in taxpayer bailout money for his Connecticut business.
Bevin dismissed the allegations, telling Fox News they are a "smoke screen" because McConnell has no record on which to stand.
Roughly six months earlier, the McConnell campaign showed its hardball tactics in a secretly recorded tape about plans for actress Ashley Judd, whom Democrats were floating as a challenger.
"I assume most of you have played the game Whac-A-Mole?" the 71-year-old McConnell is heard saying. "This is the Whac-A-Mole period of the campaign... . When anybody sticks their head up, do them out."
Staffers on the tape also seem to discuss bring up Judd's history of mental-health problems, and they purportedly worked with the FBI on finding the taping culprits.
As the 2014 election season unofficially starts after Labor Day, McConnell has a double-digit lead over Bevin and a slight lead over Grimes, though most political analysts think he will win a sixth term.
He is running in a Republican-leaning state in which Obama won just 38.5 percent of the vote last year, and GOP nominees have won the state's past six U.S. Senate contests.
In addition, McConnell has his own Tea Party support going into the primary -- the backing of the national group Tea Party Nation and Kentucky GOP Sen. Rand Paul, elected as part of the 2010 Tea Party wave.
And he has hired as campaign manager Jesse Benton, a veteran Paul-family political adviser.
Even Bevin, during his campaign announcement, acknowledged the long odds in saying: "Never in the history of American politics has a party leader in the United States Senate been defeated in the primary."
Should McConnell win the primary, he will continue to try to link Grimes to Obama, while Grimes tries to portray him as major factor in the so-called Capitol Hill gridlock.
On Tuesday, during Grimes' first official campaign stop, she suggested McConnell embodies Washington's "disease of dysfunction." And she made clear she was ready for his rough-and-tumble campaign style.
"I have a message for you, Sen. McConnell," Grimes told the crowd of supporters. "I don't scare easy, and neither does the rest of Kentucky."
Stuart Rothenberg, of the non-partisan Rothenberg Political Report, appeared earlier this month to give the final edge to McConnell, though he accepts Democrats' argument that McConnell seems more vulnerable now than he has in the past.
"He may well be," Rothenberg said. "But that doesn't mean that Democrats can beat him next year."
However, he also warned: "This is a race worth watching, and Republicans ought not dismiss the challenge."
The Associated Press contributed to this report.


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The researchers found that female bees have two different versions of a gene called csd, one from each parent, that form an active protein that triggers female development. Unfertilized eggs, which have only one copy of csd from the mother, default to being males.
In 1845, a Polish parish priest called Johann Dzierzon proposed that male bees have no fathers: They develop from unfertilized eggs, while females grow from fertilized eggs. Later work showed that Dzierzon was right. Male bees have half as many genes (haploid) as females, which get a set of genes from each parent (diploid). About one-fifth of animal species including all ants, bees and wasps use a similar haplodiploid system of sex determination, but the actual genes and mechanisms involved are not well understood.
Martin Beye and Martin Hasselmann from the Martin Luther University of Halle/Wittenberg, Germany, and Robert Page and Kim Fondrk at the University of California, Davis, isolated a honeybee gene called complementary sex determiner, or csd. Csd exists in 19 alternative versions, or alleles, Page said. Female bees have two copies of csd which are always different alleles. Males have only one copy.
The researchers worked out the DNA sequence of four csd alleles and found that they were highly variable. But the same alleles were found in both males and females, showing that there are no alleles for "maleness" or "femaleness."
Studies on developing eggs showed that in both males and females, the csd gene becomes active about 12 hours after eggs are laid and remain
Contact: Andy Fell
University of California - Davis


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It took me a second or two to "get" this one. Then I laughed so hard I... well, whatever.
Saturday, November 27, 2010
REALLY funny cartoon
Posted by Patrice Lewis at 10:00 PM
5 comments:
- AnonymousNovember 28, 2010 at 11:35 AM
Eeeeewwww...! Trouble is, after checking this fellow's underpants, they'll use the same gloves to check YOUR and MY underpants! Remember, those gloves aren't for OUR protection, but for THEIRS!ReplyDelete
Brings new EWW factor to fluid bondingReplyDelete
- AnonymousNovember 29, 2010 at 8:06 AM
OK, I'm gagging now after first Anon's true observation. Hhhyuuuk! Reeeetch!ReplyDelete
Steve Davis
Anchorage, Alaska
hmm, awesome postReplyDelete
Subscribe to: Post Comments (Atom)


text: Luminant posts loss as revenue grows Published on July 28, 2000. Luminant Worldwide, the i-marketing services venture backed by Young & Rubicam, reported a second quarter net loss of $29.1 million or $1.25 a share on revenue of $40.2 million. A year ago, it came in with a loss of $30 million or $1.25 a share on revenue of $23 million. Luminant closed July 27 at $7.25 a share, down 15.9%. Copyright July 2000, Crain Communications Inc. Most Popular In this article: News


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This page is a download link from the site http://maslatip.com/ Please click download below to download the file you want. If there is difficulty in accessing the download link, please contact the admin. Thank you for your visit. Hope can be useful!
Here are some question that are often used in National Mathematics Olympiad for student in University. This exam are usually incorporated in National Science Olympiad (OSN) Pertamina. You can download by clicking on download link below.
If you find a 404 not found in the page download, please reload the page download. You may be able to search for and download files on a national science olympiad or national exam by clicking the link below.
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text:
The Prague and Budapest offices of McCann-Erickson Worldwideare launching the honey-nut cereal with TV commercial adaptations from the network's Paris office, as mandated by the marketer, said Csilla Pal, the Nestle account director at McCannin Budapest.
TV spots and trade promotion for the cereal are already running in the Czech Republic, while in Hungary advertising andpromotion begins in July.
Copyright June 1999, Crain Communications Inc.


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Q: How do I purchase tickets to Rogue Bar shows?
A: You can purchase tickets the day of the show at the door. We have a shitty ATM on premise that occasionally works. We strongly encourage you bring cash!
Q: What time should I get there?
A: Because we don't do advanced ticketing, we encourage you to show up early to ensure entry. We are open from 6am, so no need to wait around doing nothing – you can play pool, have a drink or listen to our daytime customers argue whether Obama was born in Hawaii or Kenya!
Q: What type of payment do you accept?
A: We strongly encourage that you bring cash. It makes things easier for everyone. We even have an ATM on site! Cash-getting – made easy.
Q: How old do I have to be to attend a show?
A: You must be 21 years of age or older to enter unless accompanied by a parent. Children under 13 are not permitted. Either way, we encourage you to go enjoy your youth. Perhaps learn to play an instrument.
Q: Do I need an ID to enter the venue?
A: In compliance with Arizona State Laws, you must show a valid, non-expired, government issued photo ID to enter. This policy is strictly enforced and any violation will result in immediate ejection from the venue. We no longer accept vertical AZ IDs or vertical AZ driver's licenses.
Q: Do you allow outside food and beverage?
A: We serve drinks, so we got you boo. But ordering a pizza is fine.
Q: Where is your patio?
A: We do not have a patio where you can bring you drinks outside at this time. Please leave your drink with a bartender, or finish it, then go outside and have a smoke. Thanks.
Q: Where are you located?
A: 423 N Scottsdale Road, Scottsdale, AZ 85257. We're open at 6am and close at 2am. We're across the street from a violin shop and next to a hotel. Planned Parenthood is also located 2.5 miles away.
Q: Where do I park?
A: We have a small amount of parking spaces out front. If they're taken, go ahead and park in the neighborhood next to us. We're sure they don't mind.
Q: Is there seating at Rogue Bar?
A: We have pretty cool booths you can snag if you come early. We also have some bar stools. If you're asking if this is a seated venue: noooo.
Q: I left my card/ID/wallet/ferret/guitar/clothing at Rogue last night!
A: Oops. Give us a call real quick at (480) 947-3580 and we'll check for it! We're open 6am-2am, so you can swing by and check if you want!
Q: What is the capacity at Rogue Bar?
A: We can comfortably accommodate 100 people.
Q: Is Rogue Bar handicapped accessible?
A: For sure! If you are worried about accommodations, give us a call before the show at (480) 947-3580 and we will make sure everything is good to go!
Q: Can I bring my gun inside?
A: No. Pusuant to A.R.S. § 4-229.
Q: We are a polka-metal-folk fusion band touring from Southern Canada, can we play Rogue Bar?
A: Yeah! We have live music Thursday through Sunday and we're always looking for cool new acts to play! Please include links to your music as well as the dates you are looking for. We welcome ALL types of music at Rogue. Hit us up at email@example.com.
Q: Do you have a backline?
A: No, you must provide your own equipment. BUT we provide everything else you will need (microphones, PA, etc). We have a really great sound system and awesome sound engineers, too.
Q: Are you open if there is no show on the calendar?
A: We are open every night until 2am. Arizona law allows us to serve booze for 20 hours a day and goddammit, we're gonna use up every minute.
Q: How do I know what dates are open/what events are happening?
A: Go check out calendar, if the day is empty, we are probably open! You can also like us on Facebook and follow us on Twitter & Instagram.
Have a question we didn't answer? Contact us here for more in depth questions!


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Dates for Delbert: 1905 - 1979
Dates for Fern E. : 1891 - 1971
(I think these are actual brothers, but there is no last name.)
Contributed on 1/11/07
Record #: 13154
On this site you can upload gravestone photos, locate ancestors and perform genealogy research. If you have a relative buried in Ohio, we encourage you to upload a digital image using our Submit a Photo page. Contributing to this genealogy archive helps family historians and genealogy researchers locate their relatives and complete their family tree.
Submitted: 1/11/07 • Approved: 1/11/07 • Last Updated: 8/12/15 • R13154-G13153-S3


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Robyn Hood: I Love NY #10
|Cover A
|Cover B
|Cover C
|Cover D
|Allan Otero | Grostieta
|Riveiro | Ceci de la Cruz
|Juan Carlos Ruiz
|Renato Rei | Wes Hartman
New York State of Mind
New York City needs a guardian angel, and Robyn has unselfishly answered the call time and time again. But she's starting to wonder if that's what she really wants. Luckily, big questions are sometimes answered in small ways, even in the Big Apple.
Writer: Lou Iovino
Artwork: Sergio Ariño | Ace Continuado | Riveiro
Colors: Grostieta | Jorge Cortes | Hedwin Zaldivar | Federico Blee
Letters: Taylor Esposito of Ghost Glyph Studios
Editor: Jessica Rossana
Production & Design: Christopher Cote | Joi Dariel
New Releases are available for purchase at your local comic shop (1-888-COMIC-BOOK) and our shop!


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CINCINNATI, OH (FOX19) - As the Mercury drops, the cost to heat homes rises. For some tri-state residents, paying those high utility bills is a struggle.
For those struggling to pay high bills, the Home Energy Assistance Program is there to help. HEAP is a federally funded program designed to assist Hamilton County residents with their utility bills.
The program helps out individuals like Keynote Kennedy.
"You know, I keep the oven open to keep warm at night. That drives up my energy bill a little bit more," explains Kennedy. "I'm just trying to get a little bit of help for that."
Kennedy states that she received the help she needed thanks to the program. HEAP has also helped out Veronica Reynolds, who says her power was shut down ten days ago.
"I feel pretty good," explains Reynolds. "It's a relief taken off my shoulder. I know that my babies are going to have somewhere warm now. [I] don't have to depend on anybody."
Carol Withers says she has been without power for about a week. She claims the temperature inside of her Northside apartment has dropped well below 50 degrees.
They disconnected my utilities so I have nothing," says Withers. "I have no heat or anything and it's been very cold."
Withers says HEAP helped get her back on her feet.
Locally, more than 100 people apply daily for the Home Energy Assistance Program. The program can pay up to $175 when power is disconnected. Officials with the program say they may be able to help when utility bills become overwhelming.
"We look at each individual circumstance and we may be able to pay on someone's bill, not necessarily put them on a payment plan with Duke or a program, but we may be able to pay $175 on their bill," explains Dianne Dozier of the Community Action Agency.
Last year, the Community Action Agency was able to help more than 10 thousand people. This winter, they expect to help even more. Due to high demand, HEAP suggests scheduling an appointment early.
To be eligible for the Home Energy Assistance Program, individuals must meet certain income requirements. To learn more about the program, click here: http://www.cincy-caa.org/homenergy.asp
Copyright 2014 WXIX. All rights reserved.


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Glioblastoma is highly enriched with macrophages, and osteopontin (OPN) expression levels correlate with glioma grade and the degree of macrophage infiltration, thus we studied whether OPN plays a crucial role in immune modulation. Quantitative PCR, immune blotting, and ELISA were used to determine OPN expression. Knockdown of OPN was achieved using complementary siRNA, shRNA and CRISPR/CAS9 techniques followed by a series of in vitro functional migration and immunological assays. OPN gene-deficient mice were used to examine the roles of non-tumor-derived OPN on survival of mice harboring intracranial gliomas. Patients with mesenchymal GBM show high OPN expression, a negative survival prognosticator. OPN is a potent chemokine for macrophages, and its blockade significantly impaired the ability of glioma cells to recruit macrophages. Integrin αVβ5 (ITGαVβ5) is highly expressed on glioblastoma-infiltrating macrophages and constitutes a major OPN receptor. OPN maintains the M2 macrophage gene signature and phenotype. Both tumor-derived OPN and host-derived OPN was critical for glioma development. OPN deficiency in either the innate immune or glioma cells demonstrated a marked reduction of M2 macrophages and elevated T cell effector activity infiltrating the glioma. Furthermore, OPN deficiency in the glioma cells sensitized them to direct CD8+ T cell cytotoxicity. OPN can be exploited as an immune modulatory target, with efficacious therapeutic results using systemically administered OPN-4-1BB bispecific aptamers, increasing median survival time by 68% (P < 0.05). OPN is an important chemokine for recruiting macrophages to glioblastoma, mediates crosstalk between tumor cells and the innate immune system, and can be exploited as a therapeutic target.
Jun Wei, Anantha Marisetty, Brett Schrand, Konrad Gabrusiewicz, Yuuri Hashimoto, Martina Ott, Zacharia Grami, Ling-Yuan Kong, Xiaoyang Ling, Hillary G. Caruso, Shouhao Zhou, Y. Alan Wang, Gregory N. Fuller, Jason T. Huse, Eli Gilboa, Nannan Kang, Xingxu Huang, Roel Verhaak, Shulin Li, Amy B. Heimberger
Transplantation with autologous hematopoietic progenitors remains an important consolidation treatment for multiple myeloma (MM) patients and is thought to prolong disease plateau-phase by providing intensive cytoreduction. However, transplantation induces inflammation in the context of profound lymphodepletion that may cause hitherto unexpected immunological effects. We developed preclinical models of bone marrow transplantation (BMT) for MM using Vk*MYC myeloma-bearing recipients and donors that were myeloma-naïve or were myeloma-experienced to simulate autologous transplantation. Surprisingly, we demonstrate broad induction of T cell-dependent myeloma control, most efficiently from memory T cells within myeloma-experienced grafts, but also through priming of naïve T cells after BMT. CD8+ T cells from mice with controlled myeloma had a distinct TCR repertoire and higher clonotype overlap relative to myeloma-free BMT recipients. Furthermore, T cell-dependent myeloma control could be adoptively transferred to secondary recipients, and was myeloma clone-specific. Interestingly, donor-derived IL-17A acted directly on myeloma cells expressing the IL-17-receptor to induce a transcriptional landscape that promoted tumor growth and immune escape. Conversely, donor IFNγ secretion and signaling was critical to protective immunity, and was profoundly augmented by CD137 agonists. These data provide new insights into the mechanisms of action of transplantation in myeloma and suggests rational approaches to improving clinical outcome.
Slavica Vuckovic, Simone A. Minnie, David Smith, Kate H. Gartlan, Thomas S. Watkins, Kate A. Markey, Pamela Mukhopadhyay, Camille Guillerey, Rachel D. Kuns, Kelly R. Locke, Antonia L. Pritchard, Peter A. Johansson, Antiopi Varelias, Ping Zhang, Nicholas D. Huntington, Nicola Waddell, Marta Chesi, John J. Miles, Mark J. Smyth, Geoffrey R. Hill
Plasmacytoid dendritic cells (pDCs) play a key role in antiviral responses by producing type-1 IFNs. However, recent studies showed that pDCs induce immune suppression and promote tumor growth in human ovarian cancer and myeloma. The molecular mechanisms underlying pDC acquisition of these properties are unknown. Here we show that human pDCs activated by CpG inhibited growth and induced apoptosis in myeloma cells via secreted IFN-α, but direct contact with myeloma cells converted pDCs into tumor-promoting cells by suppressing pDC IFN-α production. E-cadherin, expressed on both myeloma cells and pDCs, mediated these effects via a homophilic interaction — activation of E-cadherin signaling upregulated and activated TNFAIP3 to interact with TLR9, resulting in TLR9 ubiquitination and degradation, and inhibition of IFN-α production in pDCs. These findings were supported by an in vivo study in which pDC depletion induced tumor regression and better survival in the Vk*MYC myeloma mouse model. Furthermore, IFNAR1 expression level positively correlated to overall survival of patients with multiple myeloma (MM), and the IFN-α level in patient bone marrow was significantly lower than that in marrow of healthy individuals. This study reveals a novel mechanism underlying how MM tumors educate pDCs in their microenvironment and provides new targets for improving the treatment of MM.
Enguang Bi, Rong Li, Laura C. Bover, Haiyan Li, Pan Su, Xingzhe Ma, Chunjian Huang, Qiang Wang, Lintao Liu, Maojie Yang, Zhijuan Lin, Jianfei Qian, Weijun Fu, Yong-Jun Liu, Qing Yi
The targeted delivery of therapeutic drugs to lymph nodes (LNs) provides an unprecedented opportunity to improve the outcomes of transplantation and immune-mediated diseases. The high endothelial venule is a specialized segment of LN vasculature that uniquely expresses peripheral node addressin (PNAd) molecules. PNAd is recognized by MECA79 mAb. We previously generated a MECA79 mAb–coated microparticle (MP) that carries tacrolimus. Although this MP trafficked to LNs, it demonstrated limited therapeutic efficacy in our transplant model. Here, we have synthesized a nanoparticle (NP) as a carrier of anti-CD3, and optimized the conjugation strategy to coat the NP surface with MECA79 mAb (MECA79-anti-CD3-NP) to enhance LN accumulation. As compared with nonconjugated NPs, a significantly higher quantity of MECA79-NPs accumulated in the draining lymph node (DLN). Many MECA79-NPs underwent internalization by T cells and dendritic cells within the LNs. Short-term treatment of murine cardiac allograft recipients with MECA79-anti-CD3-NP resulted in significantly prolonged allograft survival in comparison with the control groups. Prolonged graft survival following treatment with MECA79-anti-CD3-NP was characterized by a significant increase in intragraft and DLN Treg populations. Treg depletion abrogated the prolongation of heart allograft survival. We believe this targeted approach of drug delivery could redefine the methods of administering immune therapeutics in transplantation.
Baharak Bahmani, Mayuko Uehara, Liwei Jiang, Farideh Ordikhani, Naima Banouni, Takaharu Ichimura, Zhabiz Solhjou, Georg J. Furtmüller, Gerald Brandacher, David Alvarez, Ulrich H. von Andrian, Kenji Uchimura, Qiaobing Xu, Ishaan Vohra, Osman A. Yilmam, Yousef Haik, Jamil Azzi, Vivek Kasinath, Jonathan S. Bromberg, Martina M. McGrath, Reza Abdi
Chronic lymphocytic leukemia (CLL) is characterized by clonal proliferation and progressive accumulation of mature, B lymphocytes in the peripheral blood, lymphoid tissues and bone marrow. CLL is characterized by profound immune defects, leading to severe infectious complications. T cells are numerically, phenotypically, and functionally highly abnormal in CLL, with only limited ability to exert antitumor immune responses. Exhaustion of T cells has also been implicated as playing an important role in anti-tumor responses. The CLL-mediated T cell exhaustion is achieved by aberrant expression of several inhibitory molecules on CLL and their environment, prominently the PD-L1/PD-1 receptors. Previously, we showed that CD84, a member of the SLAM family of receptors, bridges between CLL cells and their microenvironment. In the current study, we followed CD84 regulation of T cell function. We showed that a cell-cell interaction mediated through human and mouse CD84 upregulates PDL1 expression on CLL and their microenvironment, and PD1 expression on T cells. This resulted in suppression of T cell response and activity in vitro and in vivo. Thus, our results demonstrated a role for CD84 in regulation of immune checkpoints by leukemia cells, and suggested CD84 blockade as a therapeutic strategy to reverse tumor-induced immune suppression.
Hadas Lewinsky, Avital F. Barak, Victoria Huber, Matthias P. Kramer, Lihi Radomir, Lital Sever, Irit Orr, Vita Mirkin, Nili Dezorella, Mika Shapiro, Yosef Cohen, Lev Shvidel, Martina Seiffert, Yair Herishanu, Shirly Becker-Herman, Idit Shachar
Allergic asthma is characterized by airway hyperresponsiveness, inflammation, and a cellular infiltrate dominated by eosinophils. Numerous epidemiological studies have related the exacerbation of allergic asthma with an increase in ambient inhalable particulate matter from air pollutants. This is because inhalable particles efficiently deliver airborne allergens deep into the airways, where they can aggravate allergic asthma symptoms. However, the cellular mechanisms by which inhalable particulate allergens (pAgs) potentiate asthmatic symptoms remain unknown, in part because most in vivo and in vitro studies exploring the pathogenesis of allergic asthma use soluble allergens (sAgs). Using a mouse model of allergic asthma, we found that, compared with their sAg counterparts, pAgs triggered markedly heightened pulmonary eosinophilia in allergen-sensitized mice. Mast cells (MCs) were implicated in this divergent response, as the differences in airway inflammatory responses provoked by the physical nature of the allergens were attenuated in MC-deficient mice. The pAgs were found to mediate MC-dependent responses by enhancing retention of pAg/IgE/FcεRI complexes within lipid raft–enriched, CD63+ endocytic compartments, which prolonged IgE/FcεRI-initiated signaling and resulted in heightened cytokine responses. These results reveal how the physical attributes of allergens can co-opt MC endocytic circuitry and signaling responses to aggravate pathological responses of allergic asthma in mice.
Cong Jin, Christopher P. Shelburne, Guojie Li, Kristina J. Riebe, Gregory D. Sempowski, W. Michael Foster, Soman N. Abraham
The accrual of myeloid-derived suppressor cells (MDSCs) represents a major obstacle to effective immunotherapy in cancer patients, but the mechanisms underlying this process in the human setting remain elusive. Here, we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-125a, miR-146b, miR-99b) that are associated with MDSCs and with resistance to treatment with immune checkpoint inhibitors in melanoma patients. The miRs were identified by transcriptional analyses as being responsible for the conversion of monocytes into MDSCs (CD14+HLA-DRneg cells) mediated by melanoma extracellular vesicles (EVs) and were shown to recreate MDSC features upon transfection. In melanoma patients, these miRs are increased in circulating CD14+ monocytes, plasma and tumor samples, where they correlate with the myeloid cell infiltrate. In plasma, their baseline level clusters with the clinical efficacy of CTLA-4 or PD-1 blockade. Hence, MDSC-related miRs represent an indicator of MDSC activity in cancer patients and a potential blood marker of a poor immunotherapy outcome.
Veronica Huber, Viviana Vallacchi, Viktor Fleming, Xiaoying Hu, Agata Cova, Matteo Dugo, Eriomina Shahaj, Roberta Sulsenti, Elisabetta Vergani, Paola Filipazzi, Angela De Laurentiis, Luca Lalli, Lorenza Di Guardo, Roberto Patuzzo, Barbara Vergani, Elena Casiraghi, Mara Cossa, Ambra Gualeni, Valentina Bollati, Flavio Arienti, Filippo De Braud, Luigi Mariani, Antonello Villa, Peter Altevogt, Viktor Umansky, Monica Rodolfo, Licia Rivoltini
The resolution of inflammation is an active process that is coordinated by endogenous mediators. Previous studies have demonstrated the immunomodulatory properties of the axonal guidance proteins in the initial phase of acute inflammation. We hypothesized that the neuronal guidance protein neogenin (Neo1) modulates mechanisms of inflammation resolution. In murine peritonitis, Neo1 deficiency (Neo1–/–) resulted in higher efficacies in reducing neutrophil migration into injury sites, increasing neutrophil apoptosis, actuating PMN phagocytosis, and increasing the endogenous biosynthesis of specialized proresolving mediators, such as lipoxin A4, maresin-1, and protectin DX. Neo1 expression was limited to Neo1-expressing Ly6Chi monocytes, and Neo1 deficiency induced monocyte polarization toward an antiinflammatory and proresolving phenotype. Signaling network analysis revealed that Neo1–/– monocytes mediate their immunomodulatory effects specifically by activating the PI3K/AKT pathway and suppressing the TGF-β pathway. In a cohort of 59 critically ill, intensive care unit (ICU) pediatric patients, we found a strong correlation between Neo1 blood plasma levels and abdominal compartment syndrome, Pediatric Risk of Mortality III (PRISM-III) score, and ICU length of stay and mortality. Together, these findings identify a crucial role for Neo1 in regulating tissue regeneration and resolution of inflammation, and determined Neo1 to be a predictor of morbidity and mortality in critically ill children affected by clinical inflammation.
Martin Schlegel, Andreas Körner, Torsten Kaussen, Urs Knausberg, Carmen Gerber, Georg Hansmann, Hulda Soffia Jónasdóttir, Martin Giera, Valbona Mirakaj
Interrupting T cell costimulatory signals as a strategy to control undesired immune responses, such as occur in autoimmunity or transplantation, has the potential to alleviate many of the unwanted side effects associated with current immunosuppressive therapies. Belatacept, a high-affinity version of CTLA4-Ig that blocks ligand ligation to CD28, has been approved for use in kidney transplant recipients. Despite the long-term benefits associated with its use, such as improved renal function and lower cardiovascular risk, a subset of patients treated with belatacept experience elevated rates of acute T cell–mediated rejection, tempering enthusiasm for its use. Here we demonstrate that costimulation-independent T cell alloreactivity relies on signaling through CD122, the shared IL-2 and IL-15 receptor β-chain. Combined costimulatory and CD122 blockade improved survival of transplanted tissue in mice and nonhuman primates by controlling proliferation and effector function of CD8+ T cells. The high-affinity IL-2 receptor was dispensable for memory CD8+ T cell responses, whereas signaling through CD122 as a component of the high-affinity IL-15 receptor was critical for costimulation-independent memory CD8+ T cell recall, distinguishing specific roles for IL-2 and IL-15 in T cell activation. These studies outline a novel approach for clinical optimization of costimulatory blockade strategies in transplantation by targeting CD122.
David V. Mathews, Ying Dong, Laura B. Higginbotham, Steven C. Kim, Cynthia P. Breeden, Elizabeth A. Stobert, Joseph Jenkins, J. Yun Tso, Christian P. Larsen, Andrew B. Adams
Checkpoint blockade immunotherapy targeting the PD-1/PD-L1 inhibitory axis has produced remarkable results in the treatment of several types of cancer. Whereas cytotoxic T cells are known to provide important antitumor effects during checkpoint blockade, certain cancers with low MHC expression are responsive to therapy, suggesting that other immune cell types may also play a role. Here, we employed several mouse models of cancer to investigate the effect of PD-1/PD-L1 blockade on NK cells, a population of cytotoxic innate lymphocytes that also mediate antitumor immunity. We discovered that PD-1 and PD-L1 blockade elicited a strong NK cell response that was indispensable for the full therapeutic effect of immunotherapy. PD-1 was expressed on NK cells within transplantable, spontaneous, and genetically induced mouse tumor models, and PD-L1 expression in cancer cells resulted in reduced NK cell responses and generation of more aggressive tumors in vivo. PD-1 expression was more abundant on NK cells with an activated and more responsive phenotype and did not mark NK cells with an exhausted phenotype. These results demonstrate the importance of the PD-1/PD-L1 axis in inhibiting NK cell responses in vivo and reveal that NK cells, in addition to T cells, mediate the effect of PD-1/PD-L1 blockade immunotherapy.
Joy Hsu, Jonathan J. Hodgins, Malvika Marathe, Chris J. Nicolai, Marie-Claude Bourgeois-Daigneault, Troy N. Trevino, Camillia S. Azimi, Amit K. Scheer, Haley E. Randolph, Thornton W. Thompson, Lily Zhang, Alexandre Iannello, Nikhita Mathur, Karen E. Jardine, Georgia A. Kirn, John C. Bell, Michael W. McBurney, David H. Raulet, Michele Ardolino


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Police spokesman Sam Clemens goes over the call log on Wednesday.
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As part of the Operatic PastCast
Discover the rich history of New York City's Metropolitan Opera through a series of fascinating and enlightening commentaries by Alfred Hubay, whose career at the Met spanned over six decades.
Season by season, Mr. Hubay discusses in great detail what he has witnessed at the world-renowned opera house, from his beginnings in 1943 as an usher through his impressive rise into management. His time begins under Edward Johnson, General Manager between 1935 and 1950, and continues through the Rudolf Bing years.
He shares his insights with producer Donald Collup as part of an extended project called the Operatic PastCast, which consists of 23 years of memories and experiences. Recording sessions began on February 10, 2011 and continued through July 20, 2012.
Mr. Hubay began his career at the Metropolitan Opera as an usher on October 3, 1943 and has been formally associated with the House for 62 years! His first performance was Boris Godunov on November 22, 1943. This means that he heard Ezio Pinza, for example, sing the title role not once, but eight times.
His memory is biblical in content, colorful in word, and vivid in his descriptions of his vast knowledge of the House.
In 1956, Mr. Hubay was promoted to Chief Usher. He became House Manager in 1960, and eventually Box Office Manager in 1962. After retiring in 1987, he continued to serve as a valued consultant until 2005. Throughout this period, he appeared as a panelist on the Opera Quiz during the Texaco Metropolitan Opera Broadcasts for 38 consecutive years.
In 1978, he was given the Verdi Medal for Achievement by the Metropolitan Opera National Council.
It is Mr. Hubay's desire that, through his reminiscences, you may experience the enriching world of opera.
See Alfred Hubay in Susan Froemke's 2017 documentary, "The Opera House" about the making of the Metropolitan Opera at Lincoln Center.
Susan Froemke's "The Opera House" made it New York City debut at the Metropolitan Opera on October 1, 2017.


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Beyond the gathering storm / Janette Oke.
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- ISBN: 9781441203502 (electronic bk.)
- ISBN: 1441203508 (electronic bk.)
- Physical Description: 1 online resource.
- Publisher: [United States] : Bethany House Publishers : 2005.
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Henry--a Canadian Mountie like his father--struggles between the call of duty and the call of his heart. When he informs a young logger's wife of her husband's death, the memory of that loss haunts him for years. Assigned to a new beat five years later, he rediscovers Amber and gains her trust...and eventually her heart.
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Monday, February 11, 2013
His Name was Raoul Wallenberg: Courage, Rescue and Mystery During World War II by Louise Borden
Born into a relatively well-to-do family of bankers in Stockholm, Sweden in 1912, Raoul Wallenberg was always excited and curious about everything and his endeavors were encouraged and supported by his family. At age 11, he traveled alone from Sweden to Turkey on the Orient Express to visit his grandfather, Gustaf Wallenberg, Sweden's minister to Turkey. And at age 19, he left Sweden to attend college at the University of Michigan, majoring in Engineering. When he returned to Europe, Raoul spent time travelling and as he did, he began to hear stories from Jews who has escaped Hitler's Germany, stories about new laws, beatings and even murder inflicted on Jews by the Nazi government.
Raoul had taken a job and was an excellent salesman, helped by his ability to speak different languages. But pretty soon the world was at war. As he watched country after country fall to Nazi occupation, he worried about Sweden's neutrality. Denmark and Norway, close neighbor, had already fallen to the Nazis. When roundups and deportations were announced in Denmark in 1943, Sweden gave permission for Danish Jews to enter the country, saved by the many Danish fisherman willing to sail them there. Swedish freedom and neutrality remained intact.
Hungary was also a country with a large Jewish population, but it was not a neutral and in 1944, it, too, became a Nazi occupied country. Roundups and deportations of Hungarian Jews began and many went to the Swedish embassy seeking visas to Sweden. But the War Refugee Board in America wanted a neutral Swede to organize some relief for the Jews in Hungary. Raoul Wallenberg, with his many languages and skill as a salesman, was just the person they needed.
Wallenberg devised a legal looking Protection Pass or Schutzpass that were like Swedish passports and protected the bearer from deportation. Wallenberg even created a single Schutzpass that protected whole families. But the Schutzpass, which probably saved around 20,000 people, was only one way Wallenberg worked to help Hungarian Jews.
Ironically, the man who worked tirelessly to save Jews, was picked up by the Soviet military in Hungary and on January 17, 1945, he was last seen being driven away in a Soviet car, and was never to be heard from again.
The details of Wallenberg's life and the work he did saving Jews in Hungary are all nicely detailed in-depth in Borden's free verse biography of this incredible man. His Name Was Raoul Wallenberg is beautifully put together, divided into 15 sections, each one chronicling a period of Wallenberg's life with a wealth of supporting photographs and other documents that give a comprehensive picture of his life as he grows and changes and even goes beyond his disappearance up to the present. As you will discover when you read the Author's Note at the back, Borden had the privilege of working closely with his family over many years and so had much more personal insight into the real child and man that was Raoul Wallenberg than biographers are generally privy to. And that shows throughout the book.
But His Name Was Raoul Wallenberg is more than just a biography, it is a shining example of one man who rose to the challenge at a very bleak time in history and who made a difference in the world, saving so many Hungarian Jews from certain death. Borden has written a book that is a fine addition to the whole body of Holocaust literature and anyone interested in the Jewish experience at that time.
Raoul Wallenberg was named Righteous Among The Nations by Yad Vashem in 1963 in Israel.
Come back tomorrow for an interview with Louise Borden.
This book is recommended for readers age 12+
This book was purchased for my personal library
You can find more information about Raoul Wallenberg at his alma mater, the University of Michigan, here
You can find more on Raoul Wallenberg and the plight of Hungarian Jews at the United States Holocaust Memorial Museum here
Be sure to visit Louise Borden's website here
This review also appears on my other blog Randomly Reading
Nonfiction Monday is hosted this week byAbby the Librarian
6 comments:
This looks like a fascinating read. Can't wait to see it in person!ReplyDeleteReplies
Yes,I found it to be quite fascinating. Hope you enjoy reading Wallenberg's story.Delete
I have not heard of this one. My ancestors were Swedish and Norwegian and I haven't read about many people from either country. This book sounds fascinating. I look forward to reading it. Thanks for sharing. :)ReplyDeleteReplies
You won't be disappointed, Stephanie And if you want to read a great novel about immigrants from Norway, there's an old book called Giants in the Earth. I loved it as a teen.Delete
A story like this always makes me wonder if I would have been brave enough to do something so compassionate and proactive.ReplyDelete
I'll be intrigued to check out the free verse biography! Thanks Alex for sharing and I look forward to the interview.
Congrats to Louise Borden for the win!Replies
I always think the same thing but then I stop and just hope I would do the right thing in any circumstances. A free verse biography is interesting. Free verse has become so popular not.Delete


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Business Student Awarded Scholarship
Benjamin P. Schooley, a student at Belmont University, has been awarded a Beta Gamma Sigma scholarship for his superior performance in the study of business. Schooley has received a $1,000 scholarship to continue his education in 2004-05.
Schooley is a student member of Beta Gamma Sigma and represents the top percentage of students within business programs accredited by The Association to Advance Collegiate Schools of Business (AACSB International). Membership in Beta Gamma Sigma is based on academic achievement and is extended to the best students in programs accredited by AACSB International. It is considered the highest recognition available to business students worldwide.


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Top 10 Fastest Centuries in Cricket History
The fastest centuries in cricket history can be scored only by the attacking batsmen. Whereas in this Modern World of T20 cricket, there some great and hard hitter batsman known for their attacking gameplay. But even since the early 90's destructive batsmen did existed and performed extremely well. Pakistan's Boom Boom Shahid Afridi is one of those batsmen who scored the first fastest century from just 37 balls but now the record has been broken down twice till now.
The very first time Afridi's record was broken by the New Zealand left-hand All-rounder, Corey Anderson who scored 100 in just 36 balls against West Indies. The second one is the world record by the South African 36o player Abraham Benjamin De Villiers. See the list of top 10 fastest centuries in cricket history.
10 Virat Kohli (India) – 52 balls against Australia in Jaipur on October 16, 2013
The Innings came from the 2nd ODI match when Australia tours India in October 2013 and Virat Kohli was 100* from 52 balls with Strike rate of 192 almost touching 200. In this Heroic Match winning inning, Kohli scored 7 sixes and 8 boundaries In total and was a Joy to watch from the moment he batted.
9 Kevin O`Brien (Ireland) – 50 balls against England in Bangalore on March 2, 2011
A Nightmare match for England as they were knocked out of the ICC Cricket World Cup 2011. As it was a Group B match and England scored a healthy total of 327. However, everybody on the side of Ireland lost all their hopes as the score was then 5-111 in 24.2 overs but then came the hero of this glorious Victory Kevin O`Brien who later got run out at 113 and scored his Century in just 50 balls.
8 Sanath Jayasuriya (Sri Lanka) – 48 balls against Pakistan in Singapore on April 2, 1996.
A Heroic Inning coming from the 1996 Singer Cup when the Srilankan Left handed legend batsmen Sanath Jayasuriya scored 100 in Just 48 balls. However, with this, the Lankans put forward a healthy total of 349 runs in that Match which Pakistan fell short of. Jayasuriya got out for 134 in just 65 balls. His innings included a total 11 fours and 11 Sixes with a strike rate of 206.
7 Jesse Ryder (New Zealand) – 46 balls against West Indies in Queenstown on January 1, 2014.
The Fastest Century from the New Zealander came from the 3rd ODI match of the West Indies tour of New Zealand in 2014. The Crowd of Queenstown roared as Jesse Ryder scored his Century in just 46 balls. However, Ryder got out in 104 runs out of 51 balls. This mesmerizing innings had in total 12 boundaries and 5 sixes with a Strike rate of 203.
6 Shahid Afridi (Pakistan) – 45 balls against India in Kanpur on April 15, 2005.
When Pakistan tours India in 2005 For a 5 match ODI series. A Memorable inning for Pakistan's Hulk Shahid Afridi came from the 5th ODI match at Kanpur as he hammered the Indian bowlers all over the Ground. Moreover, Afridi's 100 came from just 45 balls which were one of the fastest centuries in cricket history. He smashed 102 runs in 46 balls in this match which included 10 Fours and 9 Sixes with a Strike rate of 221.
5 Brian Lara (West Indies) – 45 balls against Bangladesh in Dhaka on October 9, 1999.
It was West Indies tour of Bangladesh in 1999 October when this heroic hundred of Brian Lara came from the 2nd ODI Match. Lara scored the Century in just 45 deliveries. In that inning, Brian Lara got out at 117 runs from 62 balls faced. Lara had in total 18 boundaries and 4 sixes with a strike rate of 188
4 Mark Boucher (South Africa) – 44 balls against Zimbabwe in Potchefstroom on September 20, 2006.
Here comes a Century from the Best Wicketkeeper South Africa ever had. Yes, you have guessed it right. It's Mark Boucher who scored his Century in Just 44 balls from Zimbabwe tour of South Africa, 3rd ODI match played on September 2006. Boucher just missed a 150 as he was 148 not out from 68 deliveries. Boucher scored sixes more than the boundaries in this match. His innings included 10 sixes and 8 fours with a strike rate of 216.
3 Shahid Afridi (Pakistan) – 37 balls against Sri Lanka in Nairobi on October 4, 1996.
Comes a historic innings from the late 90's when Shahid Afridi scored Fastest Century in just 37 balls against Sri Lanka. The inning came from Kenya for KCA Centenary Tournament on 4th October 1996. Shahid Afridi got out at 102. In his handsome innings, he scored 11 sixes and 6 boundaries. The most brutal batsmen Pakistan ever witnessed. The record of fastest centuries in cricket remained with Afridi for many years and therfore, he also got name Boom Boom Afridi by his fans.
2 Corey Anderson (New Zealand) – 36 balls against West Indies in Queenstown on January 1, 2014.
A world record of fastest centuries in cricket was broken for the very first time by the Kiwi Left handed batsmen, Corey Anderson who score a Century in just 36 balls. From the 3rd ODI Match when West Indies tour of New Zealand Corey had a date to remember as he scored this exceptional inning on the first day of the new year Jan 1, 2014. However, Corey Anderson was 131 not out in that inning from 47 balls faced. He scored 14 sixes and 6 fours.
1 AB de Villiers (South Africa) – 31 balls against West Indies in Johannesburg on January18, 2015.
AB de Villiers scored the fastest centuries in cricket history against tourist west Indies in 2nd ODI played at the Johannesburg in January 18, 2015. Where Hashim Amla scored 153 and Riley Russow scored 128 already. The 360 batsmen smashed the Windies bowlers to each and every direction of the Johannesburg stadium. De Villiers got out with just 1 run short of his 150. In that world class inning AB scored 149 from just 44 balls which included 16 sixes and 9 boundaries


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Based in London, Swift RC is an online store which provides a range of RC helicopters - both electric and nitro powered - from brands such as Align and Gaui. They also provide a wide range of affordable RC cars from ACME and FS Racing as well as self build kits for those who enjoy building models from scratch.
Swift RC has a proven track record with two radio control online stores called Helideals and RC Car Deals. Providing high level customer service is paramount to Swift RC. Emails are responded to in a timely manner and their online store is easy to navigate and provides visitors with product descriptions, features list, high quality photos and videos.
Loyalty points are offered to customers who purchase products from the RC Helicopter store. The company's online blog provides a number of different articles to offer guidance and advice to new radio control helicopter flyers, as well as remote control car racers.
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text: This two-year-old farm-to-table restaurant located in Bangall, New York is fabulous. The ingredients are sourced from nearby farms, the wines are delicious (and the bartender may let you try it before committing), the staff and owners are welcoming, the service is impeccable and the chef's and local favorites menus are amazing. If you only have time to pick up some farm-fresh milk or ice cream, you can do that at their convenient Market Cafe next door.


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Birds in Cornwall is an ongoing series of DVDs that provides recordings of the county's avian highlights observed throughout the year. This series has been produced since 1998, with the exception of 2008 to 2010. The aesthetically pleasing shots and informative commentary should make this of interest to more than just regional birdwatchers.
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University Hospitals is dedicated to helping physicians advance their knowledge, skills and professional competence through a variety of opportunities for advanced medical education.
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Six Year Highway Bill Fails to Reform Waste
When the Senate Committee on Environmental and Public Works (EPW) recently released its proposal for a six year reauthorization of the current highway and surface transportation law (MAP-21), little was included to reform long term problems or reduce waste.
According to The Heritage Foundation, one of the EPW's key failings is that the bill proposes increased spending on core highway programs, but it does not reduce spending elsewhere. This will only continue Congress's habit of "increasing spending when the money is not there, which is one reason why the balance in the Highway Trust Fund is nearly depleted."
Another key problem of the EPW proposal is the failure to eliminate the diversion of federal gas taxes to fund purely local programs and activities that have no relationship to road and bridge improvements. For example, bicycle paths and historical looking street lamps have been funded under the Transportation Alternatives Program.
Tags: Government, Highway Funding, Politics, Taxes


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Cyclist with ties to VT, CO dies in Belgium crash
October 4, 2013
JERICHO, Vt. (AP) — A U.S. cyclist from Colorado with ties to Vermont has died in an accident while training in Belgium.
The Young Telenet-Fidea Cycling team says 26-year-old Amy Dombroski, a professional cyclocross racer, died Thursday while doing speed training behind a scooter when she collided with a van.
Manager Hans van Kasteren said she was catapulted into the air, thrown 50 meters and died instantly.
Dombroski was a native of Jericho and lived in Boulder, Colo. She won three under-23 cyclocross national titles and moved to Belgium last year to train with her team.


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Because equity regards as done, what should be done. And this salad should be done. Slash "made." And I apologize to everyone not currently knee-deep in the MBE right now, but it has infiltrated all parts of my brain.
It's a seriously delicious, summery salad, perfect for all the times when your desired food prep level is hovering around "assembly." Throw in all the fruit in your fridge, add grilled chicken and goat cheese, and go back to doing property questions. Or, you know…whatever.
Equity Salad
Spinach, torn into pieces (excellent for right after you score your practice test)
Strawberries, chopped
Dates, pitted and chopped
Cucumber, chopped
Goat cheese, crumbled
M made his amazing Mediterranean chicken to put on top, and I'll have to ask him for that recipe. As far as I can tell, it involves him standing over the stove for five minutes and constantly squeezing a lemon over a pile of garlic, but theoretically there might be another step.
Happy summer, everyone! Someone better be lying on a beach in a floppy hat in my stead right now!


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Stop what you are doing, take a step back, and look at how you perform your work. You will probably agree that things are currently effective, but could be more efficient. This course will provide you with the tools and techniques necessary to enhance all the building blocks of accounting and finance. From accounts payable and cash management to budgeting and financial statements, we will show you best practices in tools and techniques that will make your job easier and help you deliver more value. The course will also cover behavioral concepts related to the day-to-day accounting and finance operations.
This course uses a mix of exercises, workshops, group case studies, and presentations. Additionally, some time will be devoted to learning practical tools in Excel for reporting, analysis and reconciliation. Conceptual ideas, rules, and best practices will also be discussed in accounting, finance, budgeting and general reporting.
Professionals in the field of finance and accounting, managers, supervisors, and finance professionals who desire to understand, apply and implement practical tools to enable them to run the finance and accounting departments more efficiently.
This is a hands-on training course using laptops which will be made available by Meirc for the duration of the training. For courses outside Dubai delegates must bring along their own laptop with a fully functional version of Excel 2010/2013.
National Association of State Boards of Accountancy (NASBA): Meirc Training & Consulting is registered with the National Association of State Boards of Accountancy (NASBA) as a sponsor of continuing professional education on the National Registry of CPE Sponsors. State boards of accountancy have final authority on the acceptance of individual courses for CPE credit. Complaints regarding registered sponsors may be submitted to the National Registry of CPE Sponsors through its website www.learningmarket.org
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Posted by Caleb on June 4, 2010 · Comments (56)
An Army "investigating officer" has banished evidence about the controversy over President Obama's eligibility – or lack thereof – to be commander-in-chief from a pending hearing for a career military doctor who announced he is refusing orders until Obama documents his constitutional status.
Military Tribunal will not examine Obama's eligibility
"In my view our constitutional jurisprudence allows Congress alone, and not a military judicial body, to put the president's credentials on trial," wrote Daniel J. Driscoll in a memorandum determining what evidence the defense for Lt. Col. Terrence Lakin will be allowed to explore at next week's hearing.
"It is my opinion the discovery items pertaining to the president's credentials are not relevant to the proof of any element of the charges and specifications set forth in the charge sheet," he continued. "Consequently I will not examine the documents or witnesses pertinent to the president or his credentials to hold office."
The ruling came prior to a scheduled Article 32 hearing for Lakin, who posted a video inviting his own court hearing because of the status of the president and questions over whether his eligibility means orders given under his control would be invalid.
Read More: By Bob Unruh, WND
Tags: obama army Lakin