text:
Jimmy Wardhana (Cultural Affairs Bureau of Macau S.A.R, Architects Association of Macau, Macao Urban Planning Institute, JWCC Architecture Co. Ltd.) / China; Macau, China
黄业雄(澳门特别行政区政府文化局,澳门建筑师协会,澳门城市规划学会,黄业雄蔡韵璇建筑设计有限公司)/ 中国;中国澳门
Patio of Macau is a result of a social neighborhood formed by Chinese community. It is a hidden layer that is weaved into the framework of urban fabric. Its significance however has always been excluded from the efforts of urban conservation and left for self-survival which gradually loses existence due to the deteriorating conditions caused by a process of rapid urban development.
What is really close to us and co-existing with us is usually forgotten and consumed by bigger and newer things. Viewing from plan is the most impactful method of viewing the urban fabric, it will reveal traces of urban development yet it does not reveal the specificity of Patios, yet this is the same issue that we are currently facing in current society.
Taking sand as an example, though homogenous from the normal eye, it reveals the beauty once it is magnified 300 times.
By magnifying its existence to the world, it makes people aware of the issue. The protruding element of the installation is like a magnification to the on-going issue that is being neglected by society, bringing it onto the same level of awareness as other urban issues. It also implies that by magnifying the patio will reveal the beauty within and re-discovering of a diminishing urban identity.
JWCC Architecture is a multi-disciplinary practice with the modus operandi of combining research, arts and culture into the core of architectural and interior design.
Half Utopia
Good Luck !
Game City
Shamate is a Kind of Sorrow
Pai Gu is Fat
Thousands of Reflections in
City Curation–
In the Name of Luohu
The Endogenous Construction Of Interior Design
First Station: Baishizhou
Urban Village Furniture Exchange Program
Game Simulation of the Urban Village
Urban Village Library
Shenzhen Case: the Regene
Multi– Dimension Urban Digital Platform: Beta– Nantou Urban Village
Data–mining the Urban Village
Home, sweet home‐an instant photography exhibition
Massive Change: Centuries of Shenzhen's Transfor
Placing Shangsha: Coalescing the Urban Village through Identity
Mapping Atlas of Shenzhen
One-House Zoo
THE GIFT BOX by GLOCAL
Hand Shake
Urban Algorithm
Roberto Burle Marx and Leonardo Finotti, a dialogue
The Story of Spring: Shenzhen 30 Years
I'm Not From Here, Either
Millennial City
Life and Death of Hubei ‐ the labyrinth of urban renewal
A Wall of Beijing
The Samsara of Building No.42 on Dirty Street
Trapped in the maze
New City
Sounding Architecture
Building Fringes
X Views
Contem-porary Images Show China's Van Goghs
Urban Playhouse: A Chinese Communal Drama in Seven Acts
Urban Villages, a Marking from Shenzhen's Urbanization Effort
CO-Design: Long-Term Community Engagement through SmallScale Home Improve
Research Towards Self-built House in Urbanvillage
Alternative Housing Practices in Guangzhou Villages-by-the
BH x SZ
Urban Village Montage
Path Breaking Shenzhen
The production of Wellbeing
Irregular / Informal / Illegal: The Production of Urban Land in the Mexico City Metropolitan Area
Shanghai Project: A Study of Workers' Village
Duo-Story of Urban Village - a shakinghand building and buildings shaking hands
Irregular Development
Designing Affordability
Dashilar Project
Automated Landscapes at the Pearl River Delta region
Urban patchwork
Invisible Villages: the Reconstruction of Belief Spaces in the Process of Urbanization in Jinjiang
Tales of Two Cities by 2017 Bi-City Biennale of Urbanism\Architecture (Hong Kong)
Invisible Cities
Ceramic - INformation
Science Fiction & Urban Village Exhibition
AUTONOMIC: the city on demand
The Why Factory The Future City is Wide
The Village Code
The Contesting Landscape: Informal Rooftop Settlement X Urabn Fishing Village, Xiamen
Magic Carpet To Kwa Wan – Creating Inclusive Places for Hong Kong's Arrival District
Four appearances of urban village
Take off, urban village! (Low Carbon City, the evolutionary future)
CI-village-TY 3.0
Poetics of Spatial Agency
Incremental Village: Elevating the Urban Vernacular of 21st Century Guangzhou, China
Mega-weaving & Microintervention 2017 GAFASCU Joint Workshop in Nantou Old town
One village, ten thoughts
"UABB Do Course at Urban Village" – Store's New Image
Small & Smart Design
Sky Farm
Restricted Urban Village Renovation
Post-it Whole- Duration Interaction Program of 2017 UABB
Nature Urban
The Five Cereal Ritual/ West find your roots
The Feast/The Square
HOUSE 17: Migrating Shenzhen Scenes
From Cacophony …
In the City
Nantou Photo Studio
Zhulang Huagai: A Figure for the Nantou Urban Village
Information Pavilion (Brick Pavilion) of 2017 UABB
Paint the Urban Village


text:
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A web hosting service is a type of Internet hosting service that allows individuals and organizations to make their website accessible via the World Wide Web. Web hosts are companies that provide space on a server owned or leased for use by clients, as well as providing Internet connectivity, typically in a data center. Web hosts can also provide data center space and connectivity to the Internet for other servers located in their data center, called colocation, also known as Housing in Latin America or France.
Until 1991, the Internet was restricted to use only ...for research and education in the sciences and engineering...[1][2] and was used for email, telnet, FTP and USENET traffic - but only a tiny number of web pages. The World Wide Web protocols had only just been written[3][4] and not until the end of 1993 would there be a graphical web browser for Mac or Windows computers.[5] Even after there was some opening up of internet access, the situation was confused until 1995.[6]
A web hosting service is a type of Internet hosting service that allows individuals and organizations to make their website accessible via the World Wide Web. Web hosts are companies that provide space on a server owned or leased for use by clients, as well as providing Internet connectivity, typically in a data center. Web hosts can also provide data center space and connectivity to the Internet for other servers located in their data center, called colocation, also known as Housing in Latin America or France.
Until 1991, the Internet was restricted to use only ...for research and education in the sciences and engineering...[1][2] and was used for email, telnet, FTP and USENET traffic - but only a tiny number of web pages. The World Wide Web protocols had only just been written[3][4] and not until the end of 1993 would there be a graphical web browser for Mac or Windows computers.[5] Even after there was some opening up of internet access, the situation was confused until 1995.[6]


text:
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The Dream Machine --- The Imagination of the World Wide Web
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Even with half a dozen writers working on the story, this still turns into a by-the-numbers comedy, where the underdogs triumph over their foes and everyone's a sore winner-loser. I do not hesitate to use the words "Gag Me!" Moranis has played this type of role one too many times. So has O'Neill, doing his usual unlovable creep act. A real snorefest, for those of you who don't have the patience to slog it out to the end.


text:
Generation 21
The Enzyme Magician
Genzyme strategy by its creator: Henri
«We continue in the heart and spirit as like
the early days.»
An interview with
Henri Termeer, President, CEO and Chairman of Genzyme,
by Jorge Nascimento
Rodrigues, editor of www.gurusonline.tv, January
Henri A. Termeer, 58, a Dutch by origin with a French
flavour, leader of Genzyme for more than 20 years, received
us with a smile. He was celebrating good news in Europe.
On January 27, 2006, the Committee for Medical Products
for Human Use, of the European Medicines Agency, adopted
a positive opinion about Myozyme, a drug for long-term
enzyme replacement therapy in patients with Pompe disease.
Pompe disease is a rare one, but fatal for children
if not treated. The marketing authorization will follow
in two months.
This is an example of the historical strategy of this
U.S. biotech pioneer, an exception to every rule in
its sector, as the consultant Cynthia Robbins-Roth wrote
in "From Alchemy to IPO - The Business of Biotechnology"
(Perseus, 2000). Since Termeer took the lead of Genzyme
from the founder scientists in 1983, with the help of
the venture capitalists, the plan was simple: create
a broadly diversified business, a market product oriented
company, with a clear goal to get profitable as soon
as possible. Today, Genzyme is focused on six broad
medical areas. «We want Genzyme as a product
company and not a research one. We have our own technology
and the capabilities to develop, manufacture and distribute
medicines ourselves, we do not license it out to others»,
says Termeer.
After a severe downtrend in mid of 2002, the close
stock price in Nasdaq went up from a low of $16.8 in
10 July 2002 to $71 in February 2006. The company today
has a market cap of $18.4b; it's third in market cap
in the TOP Biotech companies listed in NYSE and Nasdaq.
In 6 years jumped from 9th to 3rd.
Founded as a small start-up company in 1981 in Boston's
"Combat Zone" (downtown infamous district
of adult entertainment), Genzyme has evolved into a
diversified global business with annual revenues expecting
$3.1 billion by the end of 2006. With headquarters in
the heart of the Mass bio-cluster at Kendall Square,
in Cambridge, the other side of the River Charles, the
company is a true global firm, with facilities spanning
the globe in 33 countries.
Why did you decided, in 1983, to quit Baxter in
LA, left California, accept half of your salary at that
time, and move to a small office opposite to Boston's
infamous Combat Zone (the adult entertainment district
in downtown at that times) to lead as president a two-year
old start-up of scientists? What was the sex-appeal
of Genzyme?
Well, the early 1980's was the true beginning of biotech.
The field was virgin. The venture capital guys wanted
people like me to take care of these babies. We convinced
each other that was a good start. I must confess, I
always felt to start a company and built it from the
beginning. So I left Baxter's site in Los Angeles, to
move to the backstreets of Boston.
Cynthia Robbins-Roth in her famous book "From
Alchemy to IPO" wrote that Genzyme was an exception
to every rule in the bio-sector, because instead of
focusing on one technology or disease it has been a
model of diversified businesses. Why do you think this
portfolio strategy pays?
At that time we met every Saturday with the scientific
advisors to come up with the business strategy and we
developed the diversification strategy. We wanted a
diversified company that could use technology to make
a difference for people with serious deseases, and to
get profitable so we can continue to develop new medicines.
We wanted Genzyme as a product company and not a research
one. We have our own technology, we do not license it
out to others for development. Also we wanted to do
this globally. And not only represent the Boston biotech
cluster. Remember that we have a full integrated company
in Japan and we start to manufacture in Europe in 2000.
Looking ahead 10 years from now, what are the main
biotech trends you forecast?
One of the trends is related with the market in the
next 10 to 20 years. The possibility of bringing medicines
to a very large population of the world, due to emergent
countries, like China and India. This change will have
a big impact in our field. The research in stem cells
and gene therapies will have also a big role. It will
take more time, but it will play a big role. Also in
the field of the pandemic risks, biotech will have also
a significant role.
From your pipeline which drugs do you think will
be the next killer applications?
I will refer two. First, our non-antibiotic approach
to treat hospital diarrheas, a huge problem, very costly
and with an increase mortality rate. Physicians have
treated the first patients in a Phase 3 clinical study
to test the safety and efficacy of tolevamer, an investigational
polymer therapy for patients with Clostridium difficile
associated diarrhea, a form of infectious diarrhea caused
by the bacterium C. difficile. Second, we are studying
a new use for the marketed B-CLL treatment Campath®,
now for the treatment of multiple sclerosis. Results
from an interim analysis of the Phase 2 trial in MS
were highly encouraging, and the companies are working
with clinical investigators and regulatory authorities
to ensure that a comprehensive program is in place to
manage patient safety in both the ongoing Phase 2 and
planned Phase 3 studies. We will know by the middle
of the year the results. The total market for this area
is about $5 billions.
One of the greatest difficulties of the pharma industry
is the high cost of identifying new targets and compounds,
and bringing them to market as developed drugs. How
does Genzyme tackle this challenge?
For us the most important thing is to make a contribution
to the health care, particularly in rare diseases. We
want to understand the disease, and this takes a long
time. We do not work in the traditional way. We look
also to the outside, we are able to collaborate. We
think we must be open, not focused in a specific technology.
We use various technologies.
How does Genzyme identify the most promising biotech
firms to partner or to acquire?
We are very open, very friendly. We continue in the
heart and spirit as like the early days. The first criterion
is simple - many companies talk to us.
The emergent Asia is today in the breaking news
for every technology. You have offices in China, but
not in India. Why?
That's a good question. We have 3 or 4 teams studying
how to approach Indian subcontinent. It's a very big
world. For sure, we must be in India. I think before
the end of the year, we will have news about it.
What are the major criteria to attract a company
like Genzyme to build a plant or an R&D unit in
a particular country?
The country has to have particular capabilities and
we have to "feel" them. For example, Ireland
in manufacturing; Portugal in the clinical trials. Our
Research Centre in Cambridge, UK, is there because of
the cluster.
Genzyme Profile
Started at 1981 by 8 MIT scientists. Henri A. Termeer
entered in 1983 to
lead the company, convinced by a group of venture capitalists.
The start-up had only 11 employees at that time.
The name comes from the begining of the company. The
scientists extract the enzyme that comprises the medicine
from placentas.
One of the historical companies of the Biotech Massachusetts
centered at Kendall Square, Cambridge, near Boston,
where we can find also Amgen, Biogen and the pharma
giant Novartis. A study conducted by the Massachusetts
Biotechnology Council (MBC) and The
Boston Consulting Group (BCG) concluded that the Massachusetts
cluster currently employs 30,000 people at approximately
300 biotech
companies plus 150 medical devices firms. Analysts estimates
an additional 100,000 jobs will be created by 2010.
This U.S. region is home to the largest concentration
of biotech companies in the world. According to "Mass
Biotech 2010" Report (http://www.massbiotech2010.org/),
during the last years, employment in the biotech industry
has grown 10
percent annually and has contributed roughly half of
the new industrial jobs in Massachusetts. Today, biotechnology
accounts for 18 percent of the state's venture-capital
investment, 27 percent of its R&D spending, one
sixth of its public companies, and approximately 10
percent of its market capitalization. What's more, the
fact that approximately 8 percent of the world's pipeline
of new medications (pharmaceuticals as well as biotech)
is now located in Massachusetts represents enormous
potential for growth and job creation. Most biotech
observers agree on the nine major U.S. biotech clusters:
Boston/Cambridge (Massachusetts), New York/New Jersey/Connecticut,
Philadelphia, Washington D.C./Baltimore, Raleigh/Durham,
Seattle, South San Francisco/Bay Área of San
Francisco, Los Angeles and San Diego. Colliers International's
Life Sciences Group pinpoints Chicago, Houston, Indianapolis,
Memphis, St. Louis and the state of Wisconsin to be
among the emerging U.S. bio-clusters.
Genzyme becomes a public company quoted at Nasdaq through
an IPO in 1986.
Stock Market Value at Nasdaq (2005): $18.4 billion
(4% of the total biotech market cap in 2005). Third
in market cap in the Top biotech quoted in Nasdaq and
NYSE. In 6 years jumped from the 9th place to the 3rd.
The TOP 5 in 2005 in market cap: Amgen (88.9b); Genentech
(88,4);Genzyme (18,09); Biogen Idec (15,1); Celegene
Part of the Nasdaq Biotech Index, consisting of 158
After a downtrend in mid of 2002, the close stock price
of GENZ went up from a low of $16.8 in 10 July 2002
to $71 in February 2006.
Growing revenues: $2.2 billion in 2004, $2.7b in 2005;
$3.1b expected for 2006.
R&D spending: 18.5 per cent of 2005 revenues.
8,000 employees in locations in 33 countries spanning
the globe.
Genzyme ranked 51 among Fortune's 100 best companies
to work for.
Has been also selected as a member of the Dow Jones
Sustainable World Index, consisting of more than 300
leading sustainability-driver companies.
Therapeutic Portfolio: 25 marketed products in six
broad areas - LSDs (Lysosomal Storage Disorders) &
rare diseases, renal, orthopedics, transpant & immune
disorders, oncology/endocrinology, genetics and diagnostics.
Recent investments in Europe (2005): 400 million euros
in Belgium, Ireland and UK
M&A strategy: 10 acquisitions in UK and U.S. in
the last 15 years (one from 2005 is pending)
Novel financing methods: tracking-stocks method for
specific parts of the
portfolio in the 1980's and 1990's. "We segment
and give particular investors specific segments of the
business", explains Termeer. Since 2000, this strategy
was abandoned. "It is not doable anymore",
says Termeer.
Wall of fame of HB case studies: In 1993, Genzyme entered
the Harvard
Business case studies portfolio. "Genzyme: A financing
history", by Timothy A. Luehrman and Andrew D.
President Profile
Henri Termeer, 58, acepted the Genzyme challenge in
1983. The fledgling company only could pay him about
half his Baxter(previous employer in LA, California)
salary and gave him a small office.
He has been at the helm of the company since then.
He is now Chairman, President and CEO.
Dutchman by origin. Born in the Netherlands, with a
French flavour.
Previous Page | Top ^


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Are betablockers the new way to go?
Is anyone else seeing a trend in all patients with HTN receiving a betablocker during surgery or in PACU whether indicated or not? I've been giving a lot of labetalol and lopressor lately. I believe it is on the way to becoming a new core measure (as if there aren't enough already).
About gentle_ben_RN
Joined: Mar '06; Posts: 120; Likes: 22
Specialty: 6 year(s) of experience in general surgery/ER/PACUDec 30, '06Joined: Nov '03; Posts: 181; Likes: 6PACU RN, we recover fresh post op cardiac surgeries and generally I've seen betablockers given after the first 12 hours or so post op rather than immediately post op. We use the standard nipride/NTG to titrate for goal Map and the fresh hearts are usually on epi for the first 12-24 hours too. I've seen milrinone used when there are pul HTN issues.
What kind of surgeries are you seeing that require the betablockers immediately post op and are you pleased generally with the results?Dec 31, '06Occupation: RN Specialty: 6 year(s) of experience in general surgery/ER/PACU ; Joined: Mar '06; Posts: 120; Likes: 22Thanks for the reply. It's not any specific cases. The patients who have HTN and take a prescribed betablocker (usually Torpol XL) at home are receiving either lopressor or labetalol by the CRNA during the case (even when the pre-op, intra-op, and immediate post-op BP/HR is fine). It may be related to the patient having been NPO. However, some of our surgeons request the patients to take their meds with a sip of water pre-op so that the betablocker will be on board. I've heard a few of the CRNA's saying that it will be a new core measure soon, similar to what we've been doing with pre-op antibiotics.
Does your facility have anything like this regarding betablockers?
I don't know about the open hearts, they all bypass PACU where I work and go to the CVSU.
Have a great new year!Jan 1, '07Joined: Aug '02; Posts: 38,000; Likes: 37,221This does not address your topic, but I started on atenolol yrs ago when my HTN first dx by family doc. Reacted weird at first. For almost 4 days could not get out of bed at all. Did not even pee. Told doc, who didn't understand, she just told me to half the dose from 50 mg to 25 mg. Evenually I got used to that but have been extremely fatigued ever since (although other reasons). Now I have new doc who I asked to change my HTN med after long time off betablocker. She started me on ACE inhibitor and I just added inderal LA which is managing my BP quite nicely. I asked for the inderal d/t seeing 60 minutes piece recently which stated new studies using inderal for post traumatic stress disorder. I figured since I have HTN anyway, why not try it. Must say, I am doing lot better. Anxiety is being helped along with acceptable BP. (But she also put me on klonopin). But I should have had something like this a long time ago. However, still need to see cardio as far as I am concerned d/t previous episodes. Am not certain that BP is my only cardiac problem. Just wanted to talk to you b/c getting on Cardiovasc meds was scary, new; and when I tell docs (not cardiac spec) about my weird reactions they kind of dismiss my comments. Sorry to take up your time with my everyday experiences.Jan 1, '07Occupation: PACU RN Specialty: 10 year(s) of experience in long term care, med-surg, PACU, Pre-Op ; Joined: Nov '05; Posts: 45; Likes: 8I had gone to an ASPAN seminar where the use of beta blockers was talked about as the latest measure that we would see it more. It has been being used for many surgery patients to prevent heart attacks during or after the operation.Jan 1, '07Joined: Apr '06; Posts: 6; Likes: 1Our anesthesiologists are developing a new Beta blocker protocol that we will have in place in the near future. It involves preop administration (PO) of drugs for patients that meet the criteria (patient history, vascular case, etc).Jan 1, '07Occupation: RN Specialty: 6 year(s) of experience in general surgery/ER/PACU ; Joined: Mar '06; Posts: 120; Likes: 22Thanks for the input everyone. I may post some new threads about some of the latest things we've been doing in PACU where I work.
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1979 Cadillac Sedan Deville
1979 Cadillac Sedan DeVille - 37K Org Miles - Stunning All Original Car!!!
1979 Cadillac Sedan Deville
Only 37K Original Miles
Absolutely Beautiful Car, Like Showroom
New All Original Car
Super Rare Triple Aqua Color Combo
All Original Paperwork Including Window Sticker
Loaded w/Options
Mechanically Excellent
Runs & Drives Like New!
This is a beautiful, all original 1979 Cadillac Sedan DeVille in beautiful condition inside and out. It is a truly an all-original car with only 37K original miles. This Sedan DeVille is 38 years old but in every possible regard, it is virtually a new car. It is a true time capsule that has been driven an average of only 1,000 miles per year since purchased new. It has been pampered all its life and it shows! It was ordered in gorgeous and rare Atlantis Aqua with a truly amazing all original Antique dark aqua leather interior. The car rust free and is solid as rock. It is absolutely loaded with factory options, which include factory air conditioning and power everything. I have had the privilege of selling many of these cars but have rarely come across one as nice and original as this one here. Don't forget the huge 425ci power plant, just try and find another one like this!!
425ci 4bbl V8 (#'s Matching)
Power Windows
Power Locks
Power Steering
Power Brakes
Factory Air Conditioning (Blows Ice Cold)
AM-FM Radio
6 Way Power Seats
Vinyl Padded Roof
Headlamp Control
Cruise Control
Trunk Mat
Carpeted Floor Mats
Correct Spare Tire & Jack
This is an ultra clean Cadillac that has been kept in a garage and very well maintained its entire life and it shows! The exterior of this car is in beautiful condition. It has all original paint that looks amazing, finished in gorgeous and rare Atlantis Aqua with a teal pinstripe. The body is totally rust free and super straight. All the chrome and stainless on the car is in beautiful original condition and looks great. This car really shows like a diamond!
It has an exquisite, all original Antique dark aqua leather interior in it, which looks like new. Everything works in the car including ice cold air conditioning. The dash and gauge cluster looks like it just came off the showroom floor. It has never even been smoked in before. Inside the trunk is also all-original with its original spare tire and jack!
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- Engine Type
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- —
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- Sedan
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- 4
- Paint Type
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- Year
- 1979
- Make
- Cadillac
- Model
- Sedan Deville
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- 37,236
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- Antique Dark Aqua
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- —
- Seating Type
- Split Bench
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- Leather
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- Column
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- No
- Engine Size
- Transmission Type
- 3 Speed Automatic
- Body Style
- Sedan
- Miles
- 37,236
- Vin
- Stock
- 345345377


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The decision to build three colossal ship was taken in 1907 during a dinner at the home of Lord William Pirrie, chairman of Harland & Wolff. In the evening met Pirrie
Joseph Bruce Ismay, chairman of White Star Line, and President of the International Mercantile Marine (IMM), a group of companies owned by the famous American
financier John Pierpont Morgan. 1901 Morgan decided to join the growing competition between carriers for transatlantic voyages between Europe and America.
The massive wave of immigration (12 million crossed the Atlantic, only to New York, between 1892 and 1920) had made the route very profitable and superiority of
the two leading British companies was Cunard Line and White Star Line, which was already under serious threat of total German, French and Italian companies. In 1902, three years
after the death of Thomas Henry Ismay (founder of the White Star Line) decided his son Bruce to accept the offer he had received from IMM and sold the company. This
development did Cunard as the only independent British line.
The man who financed them here three vessels was John Pierpont Morgan. He who designed the Titanic was Lord Pierre, owner out of the shipyard Harland & Wolff. Row boss was
Thomas Andrews. But before we could start building them here so the ships had to redo the entire shipyard, undergoing out the old and in with the new. They had to install the new
ramps, racks, etc.. They each had to rebuild the entire shipyard to build them here three ships. As December 16, 1908 so initiated keel out Olympic. Just over three
months later, began laying the keel out of the Titanic lying next to Olympic. The vessels were riveted both manually and hydraulically.
White Star Line had done a lot of advertising for both the Olympic and the Titanic. On a poster, they played Olympic/Titanic at some of the world's highest object such as a
pyramid, Hotel Empire State Building and some other buildings. The reason why they did so was because they want to show how big their ship was
Olympic, Titanic and Britannic were built in the so-called Olympic class. It was felt that those vessels here would be those most luxurious the world has ever seen.
The vessel became best known of them here three was the Titanic which sank on its maiden voyage. Both the Olympic and Britannic served during World War I as laseret vessels.
A laseret ship is a ship that has different markings on which slaggs ship it is. Such as that Britannic was painted white with four (4) red cross on both port and starboard
which indekerade on that she was a hospital ship which had wounded soldiers brings to country and therefore did not get attacked out of enemies' ships.
The time when they built them three sisters called the Edwardian era (English: Edwardian era or Edwardian period), a period in British history that stretched
1901-1910, that is, when King Edward VII's reign lasted. Victorians Dodi January 1901, when her son Edward succeeded the throne, marked the transition
from Victorian times to the Edwardian. Often pull the boundary of the Edwardian the end slightly after the death of the king 1910, for example at the Titanic 1912
or the First World War broke out in 1914.


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Rapid urbanization in India has led to a significant rise in vector borne diseases such as Malaria and Dengue. To prevent these diseases, India needs effective and innovative vector control solutions. In line with Bayer's commitment to safeguard public health, the company has launched Aqua K-Othrine, India's first water-based space ...Read More »
The #BYOC Challenge !
The war against plastic has been waged, and it is gaining moment among residents of Bengaluru's Whitefield. And their strategy is nothing short of innovative this time. Bring Your Own Cup (BYOC) challenge calls for residents to carry their own steel glasses, plates or containers instead of using plastic or ...Read More »
Poverty rate in India reduced to half !
Over 270 million people in India moved out of poverty in the decade since 2005-06 and the poverty rate in the country nearly halved over the 10-year period, a promising sign that poverty is being tackled globally, according to latest estimates. The 2018 global Multidimensional Poverty Index (MPI) released by ...Read More »
National Deworming Day Awareness Drive by Akshayapatra !
National Deworming Day, celebrated on August 10 every year, is an initiative by the Ministry of Health and Family Welfare – a focused strategy to combat parasitic worm infections in children. GlaxoSmithKline Consumer healthcare and The Akshaya Patra Foundation, Hubbali, came together for an integrated nutrition intervention. The two organisations ...Read More »
Chhattisgarh shows growth in its Medical & Healthcare sectors
In 2003, Chhattisgarh had a serious crisis on its hand. After having just started out as a newly formed state in 2000, the infant mortality rate (IMR) and maternal mortality rate (MMR) stood at a seriously worrisome statistic: 70 deaths per 1000 live births and 365 deaths per 1 lakh ...Read More »
What goes in the ocean goes in you !
From Sea to Sea. Marine debris – plastics, metals, glass, and other solid waste materials that enter the ocean environment – can be found virtually everywhere in the ocean. 60 to 95 percent of it is plastic. Animals trying to avoid ocean plastic have to navigate a minefield. Eighteen billion pounds of it flows into the ocean every year, making it difficult for animals, ...Read More »
Think before you print !
Around the world we use 1 million tones of paper everyday and 93% of paper comes from trees alone which we can call as virgin paper. Production of recycled paper uses only half the water and 3/4 of the energy than new paper Minimal use and wastage of paper – Huge water consumption involved in paper making ...Read More »
Geriatic Clinic to be launched at Jaslok Hospital's permises
Jaslok Hospital and Research Centre has launched one of its kind Geriatic Clinic at its hospital premises on Peddar Road in the city. The clinic was inaugurated by Padma Shri awardee actress Shashikala at an event on September 16. Even though India is a young country, it's important to understand ...Read More »
Send me to School..not to Work !!
Child's EDUCATION is one concrete step, which is going to make a big difference. We all together should condemn child labor and discourage where ever it is possible from our end, as individuals and as a group Lets join our hands together for better world and better India and believe ...Read More »
Bringing School to Homes !!
Education has the potential to elevate a person and their family through the inculcation of social responsibility, increased awareness and improved financial conditions. Even as educationists are propagating the need for literacy, thousands are deprived of a proper education thanks to outdated teaching methods or a lack of true commitment. ...Read More »


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Market Wrap
Three For Three
The three biggest tech stocks have announced and all three pleased investors with the results. MSFT and INTC beat estimates by two cents each on Tuesday after the close. IBM missed by a penny due to more shares outstanding than analysts had expected but results were good despite the lagging economy. With this trio of tech giants setting the earnings standard can the rest of the sector match their marks or are we doomed to be disappointed?
Dow Chart - Daily
Nasdaq Chart - Daily
Despite the strong earnings by the tech trio, economically nothing changed. The Chain Store sales for the week were up +1.3% and the second consecutive positive week. This is a positive trend but not very encouraging. Pre-Easter is usually a strong retail period and only a +1.3% gain is mediocre at best. Retailers said the CNN effect was dwindling and shoppers were coming back into the malls for Easter, but not in large numbers.
Industrial production fell by -0.5% in March and was a larger decline than expected. All of the major market groups lost ground. Capacity Utilization fell to 74.8% and very near the lows seen in 2001. Companies do not need to buy new equipment and start new lines if 25% of their capacity is currently unused. All the factors are in place for an increase of profits without spending additional money but the demand must appear first.
Manufacturing problems are still growing as represented by the NY Empire Manufacturing Survey. The April number dropped to -20.4 from -2.8 in March. This is a drastic drop and there was weakness in all areas. New orders fell to -15.9 from -4.7, back orders fell to -26.3 from -15.5. Inventories fell to -16.6 from -3.3. This is a very negative report and should it prove to be a proxy for the next ISM we could be in deep trouble.
In earnings news GM beat estimates but then gave cautious guidance according to early reports. The stock dropped on the news but if you analyze it a bit closer maybe it shouldn't have. GM said it was "less certain" of hitting its internal earnings target of the $5.00 for the year. The consensus estimate for GM was $4.63 so anything close to $5.00 would be a win even if it did not hit the "internal" number exactly. Is that a warning? GM said higher incentive costs and the wobbly U.S. economy could impact their 2Q earnings. The stock lost -.95 cents on the news.
JNJ was the only other major earnings cloud if you don't count airlines. JNJ beat estimates by a penny but said that it was seeing slower sales of some of its bigger drugs. JNJ lost -1.80 on the news.
IBM missed earnings by a penny last night because analysts were expecting their aggressive stock buyback program to continue. They had overestimated the number of shares to be bought over the last quarter and calculated the estimates on the lower number of shares outstanding. IBM surprised them by only buying $65 million in shares because they bought Rational Software in February and that $2.1 billion cash/share drain postponed any buybacks. Other than the earnings per share number the earnings were better than expected. They said they had the second best 1Q ever in services sales. They received over $12 billion in new orders in the 1Q alone. IBM was up +2.83 on Tuesday.
After the bell Intel beat lowered estimates on all fronts and affirmed estimates for the next quarter. Intel beat estimates by two cents, revenue slightly and profit margins by 3 points. Intel had warned that margins would be "below the midpoint 50% level" during their mid-quarter update. Actually they also cautioned that revenue would also be at the low end of the range. Today they blew out all the ranges and surprised on all fronts. They did warn that flash memory sales were still hurting their overall profits. Since analysts were so kind to ratchet down their estimates after the mid-quarter guidance Intel was able to come in smelling like a rose. Their inline guidance for the 2Q will likely lead to an increase of estimates requiring another round of lower guidance from Intel at mid-quarter. Don't you love this earnings game? This is normally the worst quarter for the chip maker. INTC was trading up +.88 cents at $18 in after hours.
Microsoft threw its hat into the ring with earnings that also beat the street by two cents on better than expected revenue. There were some clouds in the MSFT report. CFO John Connors said MSFT was only seeing PC growth in the low to mid single digits through June 2004. He said growth in their subscription businesses would also be slower. MSFT guided analysts lower for full year earnings to $1.04 to $1.06 a share where the First Call consensus was $1.08. They said they expected .23 to .24 cents for the current quarter and analyst's estimates were for 24 cents. Not much but it is the second quarter MSFT has guided analysts lower. With their lower forecast for the next 12 months it could put a damper on their stock and temper the outlook from Intel. MSFT was trading up +1.05 at $25.82 in after hours.
TXN also beat the street by a penny at +.07 cents and reversed a loss of -.02 cents in the prior year. TXN also guided analysts to a gain of +7% in revenue for the second quarter. They are planning on cutting -1250 jobs in a restructuring move to cut costs and bring plants closer together.
Seagate Technology also beat the street by a whopping +10 cents and said sales of disk drives rose by +1.6 million units in the past quarter. They said by the end of June their 80GB drive would comprise virtually all of their 16 million units sold. This is an increase from 4.6 million of the 80 GB in the first quarter. The standardization of components and higher volume is helping profitability. They also declared a three-cent quarterly dividend. STX closed at $11.39.
Corning also affirmed estimates of returning to profitability by the third quarter. They said they were closing another plant and getting out of another money losing venture of making glass for televisions. They are cutting -1000 jobs and taking a substantial charge but are making progress on their recovery.
On the negative side NVLS predicted a drop of -26% in revenue on Monday due to the SARS epidemic. NVLS was off -1.06 today but analysts were trying to decide if NVLS bean counters were being honest or searching for another excuse now that the Iraq ate my earnings excuse was over.
Some good news from a non-tech sector came from MBNA, the credit card issuer, which said credit losses were easing and the worst appeared to be over in the consumer sector. This prompted gains across the board in the credit card stocks but more importantly appeared to point out that the worst may be behind us. This conflicts with the NY Manufacturing survey and the weekly Jobless Claims but any glimmer of hope is still hope.
With all the earnings news investors are glazing over to the Iraq war. Been there, done that, next! Well next could be Syria. The war of words is heating up and the U.S. said it was considering various options including military action to prevent Syria from exporting weapons of mass destruction and terrorists. They claim they have documentation supporting their claim that Syria has an advanced bio/chemical weapons program and they have been intercepting potential terrorists from Syria heading into Iraq with leaflets promising rewards for killing Americans. While this may sound like another conflict shaping up I believe it is just pressure to make Syria turn over all the Iraqi leaders who have escaped into Syria. The U.S. turned off an illegal oil pipeline that was sending 300,000 barrels of oil a day into Syria. This was a windfall for Saddam Insane and Syria as profits from the illegal oil sales went both to Saddam and Syria. That is about $250 million in additional revenue a month. Syria's cut for buying the illegal oil was a 50% discount on 200,000 barrels per day. With Syria on the brink of financial disaster already, cutting off this flow of cash and threatening sanctions is all meant to lean on them hard to turn over Iraqis. (my opinion) Not that all the other benefits would be nice as well but first things first.
Where are we going next? With the futures up strongly already and still rising(S&P +8.50 and NDX +24) there is little doubt we will explode at the open on Friday. Short of some seriously negative news event or a tech earnings disaster before the open the odds are good we will test the 1425 level again on the Nasdaq and 8500 on the Dow. Anyone still short will be buying chip stocks with both hands and enduring a large amount of pain. Most of the chip stocks were up in after hours on the TXN/INTC news. The enthusiasm for the tech trio's earnings will eventually wear off if the rest of the sector fails to meet the high standards. With Thursday before Easter normally bullish and this being a short options expiration week the volatility is likely to be huge.
Earnings slated for tomorrow include MO, AMD, AAPL, ASML, BRCM, CAT, F, GDT, HDI, JPM, NITE, LRCX, MERQ, MER, MGG, MIPS, RBAK, SNDK, SUNW, TLAB, KO, PGR, VNWK, WB and BK. These are just a small portion of the companies to report on Wednesday. 35% of the S&P report this week plus hundreds of smaller companies. We are not out of the woods yet. 54% of the companies already reported have warned about the 2Q.
The markets have seen an upward bias already this week but the volume has been very light. The volume on Wednesday will be the key. The Nasdaq only traded 1.2 billion shares today and there is a good bet it will do two billion on Wednesday. If it does it could be a major turning point in the market. If it tops out at something in the 1.5 billion range then the long term weakness could still be with us.
Make no mistake. The 8522 level has been STRONG resistance since the first rally in March. The same type of resistance equates to 1425 on the Nasdaq and it appears we will gap well over that at the open. A strong move over these levels could generate some serious short covering and some defensive buying. Everyone that expected an earnings disaster and an opportunity to buy lower could react to the rebound with knee jerk buying. If we do get over 8520 the next real resistance is 8850 and would be a serious change in market sentiment. Fasten your seatbelts.
Enter Very Passively, Exit Very Aggressively!
Jim Brown


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Exactly what is inflation, and how do we measure it? It is very important to investors, savers, and people in general, that we understand.Read More »
Monthly Archives: February 2016
Don't Ignore Silver; Its Time has Come!
Gold and silver generally move in sync with each other and tend to move in the same direction. The relationship is such that there's even an indicator that measures it – the gold/silver ratio. Many investors use the ratio to spot extremes in the pricing of either precious metal, and to spot trends, whether up or down. The ratio currently sits at approx. 80:1 and suggests that silver has some catching up to do.Read More »
The Financial Crisis "Nobody Saw Coming" IS Coming
Almost every financial crisis is presented in the mainstream media as one that "nobody saw coming" yet, as the 4 charts show below, the next one is foreseeable - "the writing is already on the wall".Read More »
Any 1 Of These 20 Stocks Could Be A 10-Bagger At Higher Gold & Silver Prices
The list of stocks provided in this post are what I consider "must own"stocks if you want big returns. Why? Because most of them are potential 10-baggers at higher gold & silver prices. These are the cream of crop when it comes to risk/reward for large returns. They all have solid projects and growth potential. They all have the "goods" and are extremely undervalued. Take a look.Read More »
Financial Crisis Now Entering A Very Dangerous Phase
Soon the problems in the world economy are likely to resume with a vengeance leading rapidly falling asset markets and currencies. Gold and silver will move up very strongly. The lucky few who can afford some physical gold will weather the storm better financially - but no one will escape the suffering that will hit the world in coming years.Read More »
Perspectives On The Great Depression & Resultant Deflation
The Great Depression was the most severe economic depression ever experienced by the Western world and it was during this troubled time that the world's most famous case of deflation also happened.Read More »
Investing In Gold & Silver: Why, When, Where & How Much?
Why should you invest in gold & silver? How much of your investment dollars should you allocate to them? Should it be invested in bullion, ETFs, mutual funds, individual mining/royalty stocks or warrants? This article provides the answers.Read More »
Big Banks Blatantly "Harvesting" Your Money! Got Physical Gold?
When prices are set by companies that can profit by manipulating or rigging them, we're screwed. This "harvesting" of our money in ever-more-creative and hard-to-detect ways is not just stealing by reaching a hand into our pocket and taking out money, but stealing in which banks can hit a few keystrokes and magically make whatever is in our pocket worth less. This is corruption at the molecular level of the economy - space age stealing - and it's only just coming into view.Read More »
Turn Today's Wealth Destroyers Into Tomorrow's Wealth Creators – Here's How
Your past and future stock market gains actually have been, and will continue to be, absolutely nothing more than a mirage - a cruel illusion - unless you develop a drastic out-of-the-box investment strategy. Here's how to do so.Read More »
Reach Your Retirement Goals By Following These 10 Axioms of Effective Investing
What's the key to making good investment choices? It isn't necessary to understand the inner workings of the securities markets or the mathematical economies underlying investment theory. Instead, 10 axioms of effective investing provide the critical cornerstone for guiding investment philosophy and making decisions. [Here they are.] Words: 2155Read More »


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Divorce in Guatemala clears presidential bid
You_ve heard of the king who gave up his throne for the woman he loved. In Guatemala, a woman is giving up the man sh...
You_ve heard of the king who gave up his throne for the woman he loved. In Guatemala, a woman is giving up the man she presumably loves for a shot at the throne. Or, at least, the presidential palace.
First Lady Sandra Torres is divorcing her husband, President Alvaro Colom, so that she can run for his job in elections later this year. The Guatemalan Constitution not only prohibits presidential reelection, as many constitutions in Latin America do, but it also bans close relatives of a sitting president from running as a candidate.
The constitution was written in 1985 when a right-wing military held sway, and the intention was to close the doors to the presidency, not widen them. Rather than attempt to change the constitution, an arduous task, Torres, who has served in Colom_s Cabinet, decided to make it so that she was not a close relative of the president. Divorce.
Public opinion was not kind, especially among the elites and other opponents of the leftist first lady. Torres was accused of having committed everything from fraud to an _assault on social dignity._ A straw poll by the Siglo 21 newspaper showed 86% of respondents condemning the divorce move.
Virgilio Alvarez, head of the FLACSO office in Guatemala, said that a kind of _Sandra-phobia_ has developed in Guatemala, whereby a lot of people just don_t like her. Not that she doesn_t have considerable baggage. Accusations of misuse of public funds (in a nation of notorious corruption) and other dark shenanigans have long swirled around her and Colom_s government. A secret U.S. diplomatic cable dated 2009 and disclosed by WikiLeaks called Torres the _most able_ member of the government and the _most abrasive._
Colom speaks of his feelings about the deal in this video of an interview with Mexican television, what both he and Torres call a "sacrifice." So far, Torres trails far in the polls, and her eligibility may yet be challenged in court.


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Holoprosencephaly (HPE) is defined as the incomplete separation of the two cerebral hemispheres. The pathology of HPE is variable and based on the severity of the defect, HPE is divided into alobar, semilobar, and lobar. Using a novel hypomorphic Six3 allele, we demonstrate that variability in Six3 dosage results in different HPE phenotypes. Furthermore, we also show that while the semilobar phenotype results from severe downregulation of Shh expression in the rostral diencephalon ventral midline, the alobar phenotype is caused by downregulation of Foxg1 expression in the anterior neural ectoderm. Consistent with these results, in vivo activation of the Shh-signaling pathway rescued the semilobar phenotype but not the alobar phenotype. Our findings show that variations in Six3 dosage results in different forms of HPE.
- Received October 20, 2015.
- Accepted October 12, 2016.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.


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Stephen Jones. Turquoise/gold brocade headpiece. Summer wear. Free size.
Turquoise and gold "Trinket" polyester brocade toque with matching feathers, crystals and beads. A "couture" piece from the "Chinoiserie-on-Sea" collection. Secured by an elastic cord and metal comb. Made in England.
Approximate dimensions: base (excluding feathers and when piece is laid flat) 23cm from side to side at widest point and 14.5cm from front to back at deepest point. Drop of 25cm from highest point of feathers to lowest tip. Fits in Medium hatbox.
Warning: Last items in stock!
Availability date:


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Water shortage?
Since March I haven't heard anything further that would suggest that we will be facing a hose pipe ban. We were given the warning that it had been a dry winter and then it went quiet. After checking the Environment Agency website it seems that there has been below average rainfall affecting groundwater although reservoirs are stable. We've had our water butt for a month now, and during this period I thought that we had received quite a bit of rain (especially during April). So I was a little surprised when we ran out on Saturday! I've been using the water for pot-bound plants and seedlings – watering whenever I've noticed the compost looking a little dry – but nothing more than that.
I guess this demonstrates that ordering the second butt as a back-up wasn't such a bad idea after all… That's Niall with his Piscean instinct! He's cleverly devised a way in which the second water butt can act as an overflow. It seems that we need to collect all the rainwater we can to see us through the summer. In theory droughts will be a distant memory, and our patch will remain forever green!


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Debbie Ocean, a criminal mastermind, gathers a crew of female thieves to pull off the heist of the century at New York's annual Met Gala.


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