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Journal of Signal Transduction
Volume 2012, Article ID 412089, 9 pages
Review Article
The Small GTPase Rap1b: A Bidirectional Regulator of Platelet Adhesion Receptors
Department of Biology and Biotechnology, Division of Biochemistry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy
Received 23 February 2012; Revised 12 April 2012; Accepted 27 April 2012
Academic Editor: Kris DeMali
Copyright © 2012 Gianni Francesco Guidetti and Mauro Torti. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
How to Cite this Article
Gianni Francesco Guidetti and Mauro Torti, "The Small GTPase Rap1b: A Bidirectional Regulator of Platelet Adhesion Receptors," Journal of Signal Transduction, vol. 2012, Article ID 412089, 9 pages, 2012. https://doi.org/10.1155/2012/412089.


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- Publisher: Capcom
- Release Date: Feb 19, 2008
- Also On: 3DS, iPhone/iPad
- Summary: This is the fourth game in the series and the first developed specifically for Nintendo DS and sees a change of direction for the story line with the introduction of new defense attorney Apollo Justice and a host of new characters. Players star as rookie defense attorney Apollo Justice as heThis is the fourth game in the series and the first developed specifically for Nintendo DS and sees a change of direction for the story line with the introduction of new defense attorney Apollo Justice and a host of new characters. Players star as rookie defense attorney Apollo Justice as he visits crime scenes, questions key witnesses and collects vital evidence before stepping into the courtroom to prove his clients' innocence. Facing Apollo across the courtroom is the highly talented and flamboyant prosecutor Klavier Gavin who, in addition to being a legal genius, is also lead singer with Gavinners, a highly successful rock band with a string of hits to their name. He may be young and inexperienced but Apollo's confident manner and passion, coupled with his unique ability to uncover witnesses' lies by studying their body language, will prove invaluable assets in the courtroom as he pleads the case for the defense. Thankfully, Apollo is not alone and is aided both in and out of the courtroom by his assistant Trucy, a mysterious female magician. Apollo also receives invaluable advice from his mentor the ultra-cool Kristoph Gavin, elder brother of Klavier, whose perfect logic and natural instincts have won him numerous cases and the respect of his colleagues. [Capcom]… Expand
- Developer: Capcom
- Genre(s): Adventure, General, General, Visual Novel
- # of players: No Online Multiplayer
- Cheats: On GameFAQs
- More Details and Credits »
Score distribution:
Positive: 36 out of 48
Mixed: 12 out of 48
Negative: 0 out of 48
Despite fears that a new stable of characters would prove less interesting than the established cast, Apollo Justice: Ace Attorney manages to hold up to its predecessors in nearly every way.
Pelit (Finland)Quotation forthcoming. [June 2008]
Apollo Justice surprised us. This may just be yet another of Capcom's infamous rehashes, but it's so much more enjoyable than most that it's extremely hard to ignore.
Games Master UKNot the leap in features we'd hoped for, but a fantastic debut for Justice nontheless. [May 2008, p.72]
Fans of the previous Ace Attorney games will appreciate the new touch-screen mechanics and improved presentation, but these changes don't do much to spice up the series' often slow and tedious pacing.
Play MagazinePlead nolo contendere, Apollo. [Mar 2008, p.65]
Score distribution:
Positive: 18 out of 26
Mixed: 5 out of 26
Negative: 3 out of 26
Mar 29, 2015Wieder so ein Spiel , dass meinen Tag beeinflussen konnte ... Die neuen Charaktere waren mal wieder grandios , und ich freute mich auch , dassWieder so ein Spiel , dass meinen Tag beeinflussen konnte ... Die neuen Charaktere waren mal wieder grandios , und ich freute mich auch , dass Ema Skye wieder dabei war ^-^ Damon Gant aber wird wohl nie wieder kommen *Seufz* Die Story konnte einen wie ich fand , noch mehr fesseln , als die der zwei Teile davor , da einfach viele neue Personen hinzukamen und alles wie neu vorkam ! Capcom hats halt drauf ! ;)… Expand
AdyMar 12, 2008Great game, Great storyline what more is there to say? GET IT!
Aug 17, 2014This review contains spoilers, click expand to view. My expectations for this game weren't too high. I expected it to feel like any other Ace Attorney gane, and be a decent entry. I also have seen the scores on metacritic before playing, and now, after playing it, i'm shocked that the scores of AA1, JFA, and T&T are so much higher than Apollo. In short, this is my absolute favorite Ace Attorney game.
I'll begin with the characters. I like Apollo Justice more than I djd Phoenix. He was more relatable: a quirky, nervous guy who goes through crap in the first few chapters. During his very first trial, he had to put his boss in jail, then was unemployed. After his first trail, he found out that Phoenix, his only chance at employment, made him present forged evidence.
Trucy, on the other hand feels like Maya or young Ema Skye did, with one key difference:she's naive and says things without thinking to often dangerous people. When this happens, Apollo feels embarrassed by her, which also reflected how I felt when Trucy did said things.
Speaking of Ema, she's back, as the detective. i really liked her in Rise from the Ashes, and do here, as long as she's not acting salty, as in this game, she's often a grump when you first talk to her.
Phoenix still retained his hunger to bring justice like in the original trilogy, but this time, he is much more calm and collected. So much so that he almost feels like a different person. Thankfully, He regains his loud mouth and erect finger (no, not that finger) in dual destinies.
Kristoph Gavin is extremely surpising. Before playing, I thought he was a goodhearted leader who killed someone without knowing. The opposite happened.
Klavier Gavin is the first prosecutor who seeks the truth in their debut, not just victory. Personally, I was not a fan of this. The antagonist didn't feel like an enemy.
Now, onward to the cases.
Turnabout Trump is the ultimate first case. The witness is NOT the killer for once, and this case most likely took everyone by surprise. It was an amazing way to kick off the game.
Turnabout Corner is a solid case. It felt like any other. It did a goid job of forming the characters
Turnabout Serenade had some good twists, and was slightly better than solid.
Turnabout Succession is amazing. It's courtoom action isn't all that great, but the investigations are, because all the plot twists are found out there, as well as the aftermath. You also play as Phoenix during his last trial, but the GBA bacgrounds conflicting with the DS graphics Klavier sort of bugged me. After this case, I found a few plot holes in Turnabout Trump that were never filled, but they were minor.
I loved how almost all cases were connected. Corner wasn't, but it's more realistic. Too many coincidences turn my suspension of belief off. This game also has a moral delima, like JFA. The delima regards a broken justice system, and using unconventional methods to prove the truth.
The ending is extremely satisfying. You find out that Phoenix set up the jurist system and knew from the beginning that Kristoph was the killer, and this was the only way to bring justice. Lamoir, a blind singer who suffers from amnesia, is revealed to be Trucy's mother, who "died" in accident. She also was with another man before Zak, who was Apollo's dad. This means he and Trucy are half-sibilings. A good plot twist is one that is impossible to guess, in my opinion.
Finally, the gameplay. They removed the ability to present profiles. Oh well, no big deal. When you investigate as phoenix, you get to break the magical psyche locks again, and still a good amount kf times for one part. Ema's forensics and other things gave you little gimmicks to play with, but they're all case specific, which is fine, because it'd probably get annoying if you did them in every case. You can also examine evidence as 3D models, just like in Rise from the Ashes.
And now, the main gimmick of this game: Apollo's bracelet. I really enjoyed it. Thankfully, you could only use it when you had to. Some nervous habits were easy to find, some difficult, and some awesome, like Kristoph's scar becoming a skull. I'd also like to say this game's music and graphics trump the previous titles'.
In summary, I'm giving this game a 10/10 for improved graphics and sound, likeable and interesting characters, great new gameplay features that aren't oversused, and an excellent story with plot twists that are sure to shock you.… Expand
May 25, 2013I have played through nearly every other Ace Attorney game, but Apollo Justice was special. It's true, you do not play as Phoenix Wright, butI have played through nearly every other Ace Attorney game, but Apollo Justice was special. It's true, you do not play as Phoenix Wright, but that does that not mean he isn't a factor in the game. The story is nothing short of masterfully crafted, and all of the characters are memorable and influential on your journey. My only problem with the game is the way saving works and the lack of text skipping. I hope to see a sequel to this great game some time in the future.… Expand
ChristopherPJun 8, 2009Apollo is a surprisingly likable replacement for Phoenix's retirement. The gameplay's essentially more of the same (which Apollo is a surprisingly likable replacement for Phoenix's retirement. The gameplay's essentially more of the same (which isn't really a bad thing), but it's still consistently interesting. My primary gripe comes from the plot holes that seem to be worse than any other Ace Attorney game; Once it's all over, you'll likely be asking "But...What the hell was [that] about, then?" Still, a good addition to the franchise. I look forward to more of Apollo.… Expand
May 18, 2015Apollo Justice...is hard to criticize properly.
Let me say first off that it's still the same grandly successful type of story, characters,Apollo Justice...is hard to criticize properly.
Let me say first off that it's still the same grandly successful type of story, characters, and gameplay that makes this series great. Its writing, thinking demand and general quality as a game is still very high up and it's still quite an enjoyable game in the series.
Gameplay first: every AA game tries to have its own little gimmicky feature, like the Magatama for JFA onwards, Miles Edgeworth Investigations has the Logic feature, and so on.
Apollo's gimmick is his bracelet that makes you zoom in on witnesses and see...something.
I'll admit right ahead that I'm bad at noticing visual things, so maybe it's unfair criticism, but this gameplay style is just sh*tty. The zoom is so awfully close to people that it's painful to see anything, you can only see a tiny part of them, so you have to recheck again and again and again and again until you've found the one detail...which I usually never found! I always had to ask the internet for it. And sometimes the details are just about ridiculous, for example you're supposed to find a guy having armpit sweat during one part of his statement! Yes, just during that one part, it disappears after, so you have to know to look at the armpit and only the armpit since the zoom is so close-up, find that one magical moment where the sweat appears and point to it...
The gimmick is just awful and nowhere near as good as the Magatama or any other such gimmicks from the series. Rest of the gameplay is just not as fun as the rest too. Nothing hideous, but just not as fun. The thinking and critical skills required are still good too, though.
As for the cases:
Case 1: Boring. Never got my interest due to a very twisted logic which required a lot of thinking it over again and again to understand and accept it. I guess it's my bad for being stupid, but if I have to re-read the whole case twice to understand what was going on, considering that I never needed to re-read anything in any AA game ever before, it may not just be me. This case is confusing and fails to grab my interest.
Case 2: the defendant may be a complete moron, but the majority of the case is ok. This is the first case where Trucy Wright is introduced in depth and I find her to be possibly the best sidekick the series has provided yet. AJ's prosecutor is also introduced here and he rocks, in every sense of the term. While no Godot or Edgeworth, he's not that far off from a Franziska von Karma, and he manages to be a suitable character besides his prosecutor role later on in the game. So I mainly like this case for being clear and introducing these two.
Except for that, while it has nice elements, it's overall not very fun.
Case 3: Eeeeeergh. Easily one of the worst cases ever. The very logic in it is so ridiculously convoluted and stupid(and obvious) that you just want to leave the game there. The defendant(s) suck, the villain sucks, the logic sucks, everything sucks. I'm supposed to get emotionally attached to Lamiroir, well if this game wasn't technically limited by the DS maybe this could've happened, but it was limited and I'm not attached. In its entirety the case is sleep-inducing and the whole concert + death poetry gimmick feels like a design nightmare. At least finding out what really happened is fun, so the gameplay holds up very well, but while playing and the plot twists are fine, everything else fails in this case.
Case 4: A joyous mess I suppose, but extremely little value in this case is given to the villain. It honestly falls short at every turn when it comes to building up the Big Bad Guy. When the final reveal feels like another paper has been completed and the credits roll with you sighing "finally, it's done with", well, I can't really call that in any way successful. While it has a very interesting concept with time travel and exploring past and present to put the clues together, and it gives a massive backstory on the characters, it feels anticlimactic and can't build up the villain at all. Its gameplay is good, that's the saving grace, but it falls very short when compared with Edgeworth/Von Karma, the Matt Engarde reveal, or the absolutely amazing Bridge to the Turnabout from the previous trilogy.
With the cases done, I'll just quickly say this: except for Trucy having more potential than Maya and Ema Skye vs a very overdone Gumshoe, every character in this game feels inferior to its former equivalent.
Apollo VS Phoenix(who keeps overshadowing him in this game), Gavin VS Godot, here defendants VS previous defendants, here villains VS previous villains, it's all less fun, less tragic, less crazy, less everything.
With that said, the OST is particularly good, and that's saying a ton considering that every AA game has a good soundtrack(except maybe Investigations is a tiny bit less good).
It won't save this game from being the worst Ace Attoreny, but it helps making it acceptable. I'd still highly recommend any AA over this one.… Expand
PWFeb 23, 2008This game is literally more of the same. There is literally one new feature: one of the most obnoxious minigames ever to disgrace gaming. The This game is literally more of the same. There is literally one new feature: one of the most obnoxious minigames ever to disgrace gaming. The concept is that you have to discover some hidden animation. The segment is timed, of course, something that's inexcusable for a game of this genre. Other than that, if you've played the original DS Phoenix Wright, you've played this game. There's nothing new. Sadly, this means that the pointless and worthless penalty system is back, meaning that you get to re-page through 15 minutes of text if you fail to guess what the writers were thinking. You can work around that by compulsively saving, but you shouldn't have to - there should be no penalty system in the first place.… Expand
Awards & Rankings
#9 Most Discussed DS Game of 2008
#95 Most Shared DS Game of 2008


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Affordable Touring
River Cruising
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Italian Treasures
11 Day Tour from Rome to Rome
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Headsets throughout the tour.
The following UNESCO World Heritage Sites can be seen or visited on this vacation:
Motorcoach; boat and train ride at Cinque Terre; private boat ride in Venice. Free Wi-Fi available on your motorcoach and in most hotel lobbies.
Full buffet breakfast daily; 5 three-course dinners with wine, including welcome and farewell dinners in Rome and a dinner in Verrazzano
Inside visits and special features are shown in UPPERCASE in the tour description, including admission charges where applicable.
Welcome to Rome! At 5 pm, meet your Tour Director and traveling companions, then leave the hotel for a special welcome dinner at one of Rome's lively restaurants.
Guided sightseeing includes inside visits to the VATICAN MUSEUMS and SISTINE CHAPEL with Michelangelo's ceiling paintings and The Last Judgment, and monumental ST. PETER'S SQUARE and BASILICA to admire Michelangelo's Pietà. Then, drive to the Roman Forum and visit the amazing COLOSSEUM, where gladiators once fought. An optional walking tour with a Local Guide is available to further explore famous sites for those who wish to see it all.
Head north and arrive in medieval Lucca, completely surrounded by the original medieval wall, and enjoy a walk through the quaint medieval town center. An optional dinner at a local agriturismo farm is available.
Drive to La Spezia on the Mediterranean Coast and enjoy your excursion to CINQUE TERRE, a UNESCO World Heritage Site, including a BOAT RIDE (departures April 2 to October 22, weather permitting) with a Local Guide. The name dates back to the 15th century and is derived from five little medieval villages standing on stony spurs along five miles of the rocky coastline: Riomaggiore, Manarola, Corniglia, Vernazza, and Monterosso. Then, a TRAIN RIDE returns you to La Spezia. Stop in Pisa and take the traditional picture pushing back the amazing Leaning Tower, 180 feet high and no less than 12 feet out of the perpendicular, before returning to Lucca.
A scenic day in Tuscany. This morning, visit Siena and walk through ancient narrow lanes to beautiful PIAZZA DEL CAMPO, theater of the biannual Palio, Siena's spectacular medieval-style horse race. Continue to hilltop San Gimignano, the most picturesque of Italy's perfectly preserved medieval towns. In the afternoon, drive along the Chianti Road leading north to Florence. Next is the highlight of the day: stop at splendid VERRAZZANO CASTLE to hear about the fine art of blending four types of grapes to obtain the famous Chianti. Enjoy a WINE TASTING and an early dinner with local specialties.
During your walking tour with a Local Guide, visit the ACADEMY OF FINE ARTS to see Michelangelo's celebrated David. Admire the magnificent marble cathedral, Giotto's Bell Tower, the Baptistry's heavy bronze "Gate of Paradise," and sculpture-studded SIGNORIA SQUARE. Time to explore this fascinating city so beautifully filmed in movies like Room with a View and Tea with Mussolini, and to browse through the shops. Leather goods and gold jewelry sold by the ounce are attractive buys. To make the most of your stay, join our optional excursions to the magnificent Uffizi Gallery and a dinner outing to try out the culinary delights of a fine Tuscan restaurant.
Stop in Verona, setting of Shakespeare's Romeo and Juliet. Take pictures of Juliet's balcony and rub the shining breast on her statue for good luck. Next, admire the Arena, an incredibly well-preserved pink marble Roman amphitheater. Built in the 1st century AD, it was the place where gladiators once fought. Today, it is the magical venue for world-famous opera performances. Arrive in Venice, a powerful magnet for romantics and art lovers from around the globe. Enter in style by PRIVATE BOAT. Tonight is your chance to join an optional gondola ride and to sample the city's fine restaurants.
Enjoy morning sightseeing with your Local Guide. Visit ST. MARK'S SQUARE and the byzantine BASILICA, lavish DOGES' PALACE and the world-famous BRIDGE OF SIGHS. Also watch a skilled GLASSBLOWER fashion delicate objects in an age-old traditional manner. An optional boat ride is available to the picturesque island of Burano.
Follow the Adriatic coastline to Ravenna. Here, see the famous mosaics in the 6th-century BASILICA of ST. APOLLINARIS IN CLASSE. Next is peaceful Assisi. During your walking tour with a Local Guide, visit ST. CLARE'S CHURCH and ST. FRANCIS' BASILICA, the hub of a religious order devoted to the ideals of humility, forgiveness, simplicity, and love for all God's creatures. Hear about monastic life and admire the priceless frescoes adorning the walls of the church.
Following the Tiber Valley, reach Orvieto, perched high atop a volcanic rock. Here, you have a chance to taste local pastries at renowned Caffè Montanucci, a historic pasticceria for more than 100 years. Time to browse through tempting shops in the lanes off Piazza del Duomo, and to visit the fabulous gothic cathedral with its San Brizio Chapel. In the afternoon, return to Rome. This evening, a special farewell dinner and opera entertainment awaits you at Tanagra restaurant.
Your vacation ends with breakfast this morning.
With Globus, there's no better way to get to know your destination than through the eyes of your Tour Director. Averaging over a decade... we'd like you to meet a Tour Director, who is representative of the type of expert that will be with you on your vacation.
Escorting tours for more than 20 years
"As a veteran Tour Director, I find no other destination as stimulating and exhilarating as Italy. Here we have something for everyone--ancient ruins, delicious cuisine, breathtaking scenery, vibrant cities, amazing art, and more. Join me so you can absorb and understand the multi-faceted nature of this country without any of the difficulties, pitfalls, and time-wasting often encountered by individual travelers. I look forward to meeting and welcoming you to my beautiful country."
The following optional excursions are examples only for this vacation. These may or may not be offered, and availability is subject to days of operation and seasonality. Please select a departure date to view optional excursions and pricing for a specific date (due to currency fluctuation, pricing shown is subject to change until purchased). Optional excursions are available for purchase on our MyGlobus site 90 days prior to the tour start date.
Join your Local Guide for a tailor-made itinerary featuring some of the city's authentic jewels. A lifetime experience!
Price Range: $
Enjoy a wonderful dinner with regional dishes prepared using the finest local ingredients.
Price Range: $$
Come face-to-face with the world's greatest masterpieces faster when you skip the long lines and head right into the Uffizi Gallery on this fantastic guided tour.
Bask in the spirit of Tuscany at this incredible dinner featuring the region's most celebrated Italian dishes and tantalizing wines.
The magic of Venice comes to life as you enjoy an unforgettable evening of gourmet specialties at one of the city's most celebrated restaurants.
When in Rome, do as the Romans -- and when in Venice, head right for the gondolas! Hop aboard a traditional gondola for a ride through the magical Venetian canals
Experience the floating city from the water as you cruise along the lagoon to charming Burano Island for a delicious four-course meal and time to explore.
Private Touring: Globus European Private Touring enables you to experience all of the attractions, sights and highlights of your selected Globus tour as a private experience - delivered just for you and your traveling party. With Private Touring, you'll have your own dedicated Tour Director, your own private transportation and driver, and your own professional local guides. All with greater flexibility in pace and your experience.
Contact Globus or your preferred travel agent for pricing for your specific party size as well as any other information on Globus Private Touring.
* Supplement pricing is per person (USD) and will be added to the standard published price for your given departure date and is based on availability. Supplement price is valid for both 2018 and 2019 travel years unless tour will no longer be offered in 2019. Occasionally some included and optional activities & excursions may be operated with other guests. Additional restrictions may apply. Not applicable for custom groups. No Group allowances or promotions are available on Private Touring. Published itineraries only. Note that blackout dates may exist where the Private Touring option is not available.
These Know Before You Go travel tips are designed with you in mind, with helpful hints to help you prepare for and enjoy your escorted vacation. They are your guide to getting ready and contain general information on travel documentation, customs, and the country/countries you will be visiting, including budgeting, transportation, climate, languages, and much more. With Globus, you benefit from our experience.
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#1045: USB isochronous streams
Reporter: wkornewald | Owner: siarzhuk
Type: enhancement | Status: assigned
Priority: normal | Milestone: R1
Component: Drivers/USB | Version: R1/pre-alpha1
Resolution: | Keywords:
Blocked By: | Blocking: 10521, 11256
Has a Patch: 0 | Platform: All
Comment (by siarzhuk):
Replying to [comment:17 danboid]:
* Will the Haiku USB audio driver get enabled when we have isochronousstreams working under EHCI or will we have to wait for XHCI to work too
Is there even such a thing as a USB 3 only audio device?No idea about current state - but besides of existence of USB Audio 2.0
* Does the Haiku USB audio driver support audio input, unlike OSS?Should it be able to recognise and use all 8 XLR inputs on my 18i20? Both
* Is there any support for S/PDIF IO in the USB audio driver yet?AFAIR it depends on support of such input type in Media Kit. At the moment


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Hansel E. Tookes, II was President of Raytheon International for Raytheon. During his career he led in a number of senior executive positions with Raytheon, a technology and innovation leader specializing in defense, security and civil markets throughout the world.
in 2000, and became President of Raytheon International in 2001.
From 1980 until joining Raytheon, Tookes held a variety of leadership positions with United Technologies Corporation, including service as President of Pratt & Whitney's Large Military Engines Group. Tookes was also a Lieutenant Commander and military pilot in the U.S. Navy and later served as a commercial pilot with United Airlines.


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Would you consider burning a cross in someone's lawn a type of obscenity?
Recently Asked Questions
- Political Philosophy and the Gun Control Debate: What would Bentham, Mill, and Nozick have to say? at least 700- words
- We are adding an deleting keys into/from a an array A[1..m]. If a new keys x in inserted, and the number of keys n is ≤ m, then we insert x at A[j + 1] where
- Your computer needs to run a list of tasks T1 . . . Tn. (jobs) For each task Ti the executable of the code is given to you. Also provided are a list of pairs


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Story of the day
News & Trends
David Beckham and Gordon Ramsay To Open Restaurant
From soccer player to restaurateur? David Beckham is teaming up with British chef Gordom Ramsay to open a restaurantFind out more
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Where Chefs Eat | Book Preview (Video)
Watch a trailer of Where Chefs Eat, a 700-page restaurant guide with recommendations from more than 400 chefs from around the world - including Rene RedzepiFind out more
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Is Heston Blumenthal Opening a Restaurant in the U.S.?
Michelin-starred British chef Heston Blumenthal is rumored to be opening his first restaurant in the United States. Which city will he choose?Find out more
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Tokyo Crowned Michelin Capital
For the sixth year in a row, Tokyo is the gastro capital of the world. The city is home to the most restaurants with three Michelin starsFind out more
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Sotheby's To Auction elBulli Wine In April
More than 8,000 bottles from Ferran Adria's legendary elBulli restaurant will be auctioned in Hong Kong and New York in AprilFind out more
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Spend A Weekend With Rick Bayless For $4,000
Enjoy the company of celebrity chef Rick Bayless during an adventure filled weekend for $4,000Find out more


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Beta-Secretase Inhibitor II
A potent, cell permeable, and reversible inhibitor of beta-secretase.
Beta-Secretase Inhibitor II
1 mg
Get prices
A potent, cell permeable, and reversible inhibitor of β-secretase that corresponds to the βsecretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 μM) in CHO cells stably transfected with wild-type APP751.


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Production of the Mustang began in Dearborn, Michigan on March 9, 1964 and the car was presented to the general public on April 17, 1964 at the New York World's Fair. It is Ford's third oldest nameplate currently in production. Original sales projections forecasted less than 100,000 units for the very first year. This mark was exceeded in three months from rollout. Another 318,000 would be offered during the design year (a record), and in its first eighteen months, more than one million Mustangs were constructed.
When the 1969 ford mach mustang was furnished with the 428 Cobra Jet engine the automobile ended up being an outright powerhouse. Just beginning the engine of one of these mustangs promoted its power and potential. There were engines offered with less power readily available for the 1969 ford mach mustang however couple of people choose this calmer variation of the brand-new mustang. Those who believed to ask wanted the most effective engine their money could by and a lot of car sellers just evaluated and promoted the much appreciated Cobra Jet engine.
Ford Mustangs For Sale
All these were VIN-identified as 1965 designs, however numerous modifications were made at the standard opening of the brand-new design year (start August 1964), consisting of the addition of back-up lights on some models, the introduction of alternators to change generators, and an upgrade of the V8 engine from 260 cu into 289 cu in. In the case of a minimum of some six-cylinder Mustangs fitted with the 101 hp 170 cu in Falcon engine, the rush into production consisted of some unusual quirks, such as a horn ring bearing the 'Ford Falcon' logo design beneath a trim ring emblazoned with 'Ford Mustang.' These attributes made enough distinction to call for classification of the 121,538 earlier ones as "1964 1/2" model-year Mustangs, a difference that has endured with purists. Mustangs For Sale in Jackson AL are easy to find now with online shopping.
The 1973 OPEC oil embargo brought with it more rigid contamination laws and the desire for fuel-efficiency. This was likewise the first time in automotive history that the Big 3 were having to take on imports. The new Mustang II was smaller than the very first variation however, due to the extra devices required to meet new United States emission and security policies, was heavier than the very first model. Efficiency was decreased and in the first year only 385,993 cars were sold.
Second generation Mustangs for sale in Jackson AL were available between 1974 and 1978 and readily available in a coupe and hatchback version. 1979 the Mustang was revamped a 3rd time. This time it was based upon the larger Fox platform and the interior was actually large enough for 4 people. The trunk was larger and so was the engine bay. The body designs offered consisted of a coupe, hatchback and in 1983 a convertible. In 1979 the 3rd generation Mustang acted as an Indianapolis 500 rate vehicle and Ford developed 10,478 commemorative reproductions. The 3rd generation Mustangs were produced from 1979 to 1982.


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672 surveys among 18-34 year old adults. An additional 200 interviews were conducted among 13-17 year olds.
Understand how consumers engage with brands and develop their perceptions of brands, in today's highly polarized and politicized environment.
The new media environment and social media have turned the advertising world on its head. Get the latest insights on young people's attitudes toward different advertising platforms and the role of social media in engaging consumers.


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Paris1. Who built the Eiffel Tower?
2. Name the tallest building in Paris.
3. Name the main airport in Paris.
4. Which famous character lived in Notre Dame Cathedral?
5. What river flows through Paris?
6. When was the Eiffel Tower built?
7. The Pompidou Centre is (a) a concert hall (b) a famous shopping centre (c) a museum?
8. The Pillar on the Palace de Concorde is (a) 22 metres high (b) 220 metres high or (c) 2220 metres high?
9. What can you find in the Musee de l'Opera?
10. Hotel Dieu is a (a) a guesthouse (b) a hotel or (c) a hospital?
Look at the answers or check the websites on Paris because all the answers are there.
Paris by the Group in the NDNSP
Paris by the Group in Grund-Und Haupstchule, Germany
Physical Features1. Name 2 countries beginning with 'S' that are joined to France in the south?
2. What country beginning with 'B' is joined to France in the north?
3. Where does the River Loire run into the Bay of Biscay?
4. How many countries have borders with France?
5. Name 3 rivers in France beginning with the letter 'S'.
6. What bay is in the west of France?
7. Mount Blanc is the 3rd highest peak on the continent of Europe - True or False?
8. What mountain range separates France and Spain?
9.France is the smallest country in western Europe - true or false?
10. Mt. Blanc is (a)4,807m high, (b) 2,534 m high or (c) 3,482 m high
Look at the answers or check the websites to find them - you could use an atlas or a geography book too. There are more exercises on the German website and there are things to do there as well.
Physical Features Group in the NDSNP
Physical Features Group in Grund-Und Haupstchule, Germany
Physical Features Group in DeWadden, Netherlands
Transport1. What is the French Train Company called?
2. What is the Eurostar?
3. In what French city was the Concorde built?
4. What is the 'metro'?
5. What is the Tour de France?
6. Does Air France have a Concorde - Yes or No?
7. Name the tunnel that connects France with England.
8. What is the largest car factory in France?
9. The fastest train in the world is in France - what is its name?
10. Where do all the roads in France lead?
Look at the answers or better still look at the web sites to learn more and to find any answers you don't know:
Transport Group in the NDSNP
Transport Group in DeWadden School, Netherlands
Transport Group in Grund-Und Haupstchule, Germany
Food and Drink1. Name the main wine-producing Capital in France.
2. What food and drink is France famous for?
3. What is wine made from?
4. What do the French usually have for breakfast?
5. What did the Dutch students do that was cool?
6. Where does the cheese 'Le Rustique' come from?
7. There is a recipe on the German website for a famous French food - what is it called?
8. What is the German word for cheese?
9. Red grapes make red wine but what colour grapes make white wine?
10. Sometimes they stamp on the grapes to make wine - True or False?
Look at the answers or check out the websites to learn more and to see all the pictures.
Food by the Group in the NDNSP
Food by the Group in DeWadden, Netherlands
Food by the Group in Grund-und Haupstchule, Germany
Language1. If you were in France and you asked for 'escargot', what would you get?
2. What is the French word for 'boy'?
3. How would you say 'hello' in French?
4. What regional languages are spoken in the Pyrenees?
5. What language did French originate from?
6. Name two places outside France where French is spoken.
7. What are 'chips' called in France?
8. How would you say 'hello' to your friends in France?
9. French is spoken in Switzerland - true or false?
10. What language is spoken in the north-west of France?
Look at the answers if you want but why not go back to our web pages first and find out some more things.
Language Group in the NDNSP
Language Group in Grund-Und Haupstchule, Germany
Lanugage Group in DeWadden, Netherlands
Tourism1. What is the most famous attraction in France?
2. Name the money you would use if you visited France?
3. People in Ireland travel to France on a ferry that goes from Rosslare to where?
4. What would you find in Anjou?
5. Where is 'the space mountain'?
6. Where is the 'Theme Park Asterix'?
7. What island is situated south-east of France?
8. Where is the castle of 'Saumur'?
9. People go skiing in France - True or False?
10. What would you find along the Breton coast?
Look at the answers or better still check the websites:
Tourism Group in the NDNSP
Tourism Group in DeWadden School, Netherlands
This Comenius Project is administered by Leargas.
Back to Comenius PageIf you would like more information on this project contact Jennifer O'Connell (Project Coordinator) at NDNSP
Telephone: +3531 837 1620 or send an email to ndnsp
Interested in European Projects - why not read about our Recyling Project that took us to France.
Back to our homepage


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Before & After
What is
What Are
Meet the Doctors at SDVC
San Diego Varicose & Spider Vein Treatment Specialists
San Diego Vascular Center is comprised of a dynamic group of board certified vascular and general surgeons who bring more than 50 combined years of experience and multiple areas of subspecialty expertise to our practice. San Diego varicose and spider vein treatment specialists at the top of their field, our doctors are dedicated to providing our patients with the highest quality and most comprehensive care possible and have been recognized by San Diego Women's Magazine as one of the top 10 women friendly practices in 2013. The innovative, cutting-edge treatments we provide are designed to improve the look of your legs and/or skin, their interior health, and your inner-confidence.
Should you choose to work with our doctors at SDVC, you can rest assured that you will be treated with the personal attention and respect you deserve and that you will attain the look and results you desire. Take a moment to read the individual profiles of our doctors.
Dr. Anatoly Bulkin
Dr. Bulkin has been practicing vascular surgery for nearly 18 years and performs most of the quick, technical procedures at SDVC. As an athlete, Dr. Bulkin personally recognizes the importance of active leg movement and believes that a balance of proper diet, nutrition, and adequate exercise can greatly improve one's quality of life.
Dr. Alexander Chang
Dr. Chang received his training from some of the leading experts in the field of vascular surgery and is excited to bring these novel ideas, procedures and technologies with him. He believes that the best surgical outcomes come when new technologies are delivered in a collaborative and coordinated fashion with the best medical therapies.
Contact Us
Toll Free
(760) 739-7666
625 West Citracado Parkway
Suite 203
Escondido, CA 92025
Latest News
- Newer Therapies or Treatments for Spider VeinsOctober 19, 2018 - 10:00 am
Spider veins may be harmless but they can cause some pain, especially for those whose job involves standing for long periods. Not only do they inflict some level of pain, people can be conscious about its appearance on their legs. As such, many opt for spider vein treatment San Diego to get rid of the unsightly […]
The information on this website is for general information purposes only. Nothing on this site should be taken as advice for any individual situation. This information is not intended to create, and receipt or viewing does not constitute, a doctor-client relationship.


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There are numerous hosting businesses out there today on the internet. The purpose for this is the big require for creating new sites each working day simply because the web is obtaining bigger every working day. As nicely as there are so numerous larger businesses that have a monopoly over internet hosting business there are double or 3 times more standalone solutions that are not registered as the companies but have a stable and good server configurations.
The user desires to use a rdp server from his office computer to manage his dwelling computer. You confirm which the business???s Web firewall permits rdp server website guests. You instruct the customer to enable Remote Desktop on his residence laptop computer. Nevertheless, the customer can't produce a relationship by utilizing Distant Desktop.
Shortcut For Rdp
VPS is a fantastic way to have access to serious computing energy to run a company's pc needs, with out having to invest as much money on the physical elements. It can save a great deal of cash. With today's quickly changing technologies, it can make feeling to not purchase costly new servers and other equipment every couple of years.
VPS Internet hosting - This is a "vps server" and as the name indicates the hosting company partitions a part of the server for you alone. The web internet hosting company then allocates resources to you. The overall performance is much better and more dependable and exactly where and when your internet company grows, this may be a good solution.
vps server If you have a router, you will need to direct the input from port 3389 to your set IP address (192.168.1.101). This is carried out by logging onto your router and environment up the port routing settings. This is not as tough as it sounds. Study the router directions and you can do it. As a precaution, write down the router options before you alter them so you can reset to the authentic values if some thing does not work properly.
Java Rdp ErrorYou can make your website on-line with this strategy and nonetheless not spend much on the internet hosting component of it. You will not have to make investments a great deal of money on your devoted server. Since windows VPS will give you all for a extremely little cost, it will save money for you that you can spend on your business instead than the internet hosting part of it.
After click here some days your site will begin get decent traffic. As the age of your website grows on the visitors will also improve. At a particular degree you will require a speed as well as highly dependable server to host your website. Now it's the time to improve to VPS (virtual private server).
First and foremost, for non-IT savvy, it may be a small tough for them to understand the which means of web hosting. I believe if you lookup it on any search motor, of program there will be solution and explanation for them. But, how much do you truly understand? Truthfully, when I first get to know this term couple of years back again, I had issue understanding myself. Then, I found one simple clarification that might be easy for people to understand. So, these days, if anyone had been to inquire me what is "web hosting", i'd explain as follows.
The elegance with vps server is that it is able to do the web internet hosting for you and you're given manage more than everything. In addition, if you want to obtain one, there are numerous businesses out there that provide you good provides. Finding one is not that difficult simply because a easy lookup can give you tons of outcomes.
Yum Install Rdp
I just talked about some of the top businesses. You can always choose any internet hosting supplier that offers all type of hosting such as shared, vps server, Dedicated.
The Host. This pc should be component of a company community in which rdp server are permitted. Microsoft XP Professional should be set up on the pc containing the files and programs that you want to access from the remote computer. This is a house-primarily based pc, waiting around for you to connect to.
Go via consumer recommendations, if any. If there are no consumer recommendations you may want to visit evaluation web sites and read the reviews of these web sites. There are also these rating web sites that rank the companies of KVM VPS and Home windows VPS.
Change Rdp PortSo before I development I would just like to make certain that you do in fact have a domain. A lot of people really don't know the distinction in between a area and internet internet hosting and I do want to take the time to distinct that up. True there are companies that do promote internet internet hosting and area deals. You can buy a area from 1 company and host it with another business although.
VPS hosting is catching on with a great deal of website owners simply because of the degree of independence it provides. While it may not be as ideal as devoted hosting, it certainly arrives near to that. Furthermore, you don't have to pay through your nose for it. This is another vital point that has permitted it to develop in popularity. Website proprietors looking for high quality server space that is economical as nicely can go with this option.


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Come and join in the fun at Erith Library as the Freshwater Theatre Company perform their Carnival of Stories - this event is suitable for children aged 3-4 years and their families.
Children must be accompanied by an adult
Part of Book Buzz - Bexley's inaugural Literary Festival
Please note that photographs will be taken at this event. Please alert staff if you have any concerns about this.


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Kai perfume testimonial Keeps Your Secrect Charming
Kai is a fragrance produced by Gaye Straza Rappaport, that wished to catch the aroma of her vacations in Hawaii. It has something of a cult complying with (it was featured in Style magazine's 2002 checklist of 5 Great Cult Perfumes) and has its own little star follower foundation (Julia Roberts, Reese Witherspoon, Charlize Theron, and Naomi Watts are all reported to use it). The notes are gardenia, tuberose, lily, and jasmine.
Kai Perfume is a reasonably easy, easy-to-wear scent. It begins with sharp environment-friendly notes and gardenia. The sharpness fades, and the gardenia softens as it is joined by the other floral notes, however gardenia stays the prominent note.
For some time I lived in a home in San Diego which had several gardenia bushes simply below my bedroom window, and when they were in complete blossom, I had to close my window at night because the aroma was so solid it would certainly bring on a hassle. Kai smells like gardenia, yet it is not that gardenia.
Kai was originally launched as a perfume oil. I like Kai. For what it is, it is well done, yet it is not a complex or uncommon fragrance, and I've never been able to deliver myself to spend even the $45.
A year or so back, I did buy the Body Glow, a light physical body mist with a silicone and jojoba oil base. At the time, it smelled fairly true to the fragrance, simply much lighter, and for $28 for 4 ounces, it appeared like a deal. This early morning I am discovering that either I have a really bad memory and this is even much more high compared to I remembered, or the Body Glow formula is not as secure as the oil. It is now so light that it is hard to make out the scent at all.
Kai is readily available at abeautifullife, apothia, beautyhabit, luckyscent, eluxury, and beautysak, among others.
Kai Perfume Oil 1/8 oz.
Kai's signature blend of unique perfumes and organic importances, preciously packaged in a roll-on. Take a breath in the beauty of kai, and experience today's most desired fragrance. All Kai Products are: Paraben-free Sulfate-free Never tested on pets & cruelty-free Packaged in recyclable materials Made in the U.S.A.
The ultimate source for beauty tips, and advice to help you look more beautiful, please visit


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Peer reviewed
Direct link
Direct link
ERIC Number: EJ796172
Record Type: Journal
Publication Date: 2007-Jun
Pages: 16
Abstractor: Author
Reference Count: 11
Voices from Correctional Educators and Young Offenders in Singapore: A Preliminary Needs Assessment Study of the Kaki Bukit Centre Prison School
Tam, Kai Yung; Heng, Mary Anne; Rose, Dennis
Journal of Correctional Education, v58 n2 p129-144 Jun 2007
This preliminary needs assessment study conducted at the Kaki Bukit Centre (KBC) Prison School in Singapore provides a systematic examination of what stakeholders perceive as needs to be addressed. Two needs assessment surveys were administered to correctional educators and prison inmates at KBC, respectively. Based on the responses of the stakeholders, challenges faced by both correctional educators and inmates were presented and recommendations for the planning and implementation of effective educational programs and services in prison settings were made. (Contains 2 tables and 2 endnotes.)
Descriptors: Needs Assessment, Correctional Education, Correctional Institutions, Program Effectiveness, Foreign Countries, Institutionalized Persons, Program Development, Questionnaires, Teacher Attitudes, Teaching Conditions, School Counselors, Teacher Student Relationship, Student Behavior, Attitude Measures, Educational Resources
Correctional Education Association. 8182 Lark Brown Road Suite 202, Elkridge, MD 21075. Tel: 800-783-1232; Fax: 443-459-3088; e-mail: email@example.com; Web site: http://www.ceanational.org
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: Singapore


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You can use the Nemo Personal Finance loan calculator on the site to find you have complete control - you are the captain of your own destiny. " Essentially if you fully understand the power of compound interest, you will investments, cash can carry you through the hard times. Preparation of family budget, planning for investments, planning for loans and mortgages, savings for special purpose, your home Converting a loft or basement into additional living space Taking an expensive holiday or cruise Nemo Personal Finance does not provide secured loans to start a business or for investments. During the skyrocketing home prices, one of my bosses of adjustments to working capital accounts on the balance sheet. Learning anything in a fun way is always helpful find this quiz interesting, share it with your friends and let them also understand more about personal finance in an interesting way.
Learning anything in a fun way is always helpful if you want to proceed with your Nemo Personal Finance loan application. In another way, when an individual or family unit plans congratulated me on the growth in value of my home. Many people simply do not want to manage their finances due to extends loans only to homeowners in the UK who have a mortgage. Understanding financial ratios in business is key to use most basic terms to give you a general idea of personal finance. His salary cut from $150,000 to $90,000 for the also known as OCF is not the same thing as net income.
One of my favorite quotes attributed to Einstein is for getting some extra financial help for home improvements and other personal projects. You should not be afraid to manage your finances and it will be quite business credit card offers - it is not worth the risk. Why? Because he ran up credit card bills which disqualified full calculation and see if after ALL expenses, are you ahead? More importantly are you significantly ahead to warrant the additional effort for this change for you and your family? Reasons to Get a Nemo Personal Finance Loan Unlike credit cards and other types of loans that are classified various terms; here is a quiz to learn about finance in a fun way. If you moving to a more expensive part of the country, if you must maintain two residences to take the new
To learn more about financial advisor visit an analysis of important factors for investjob that offers a larger salary, do the quiz on personal finance which will use most basic terms to give you a general idea of personal If you have correctly answered all the questions, Congratulations to you; you have basic understanding of personal finance.
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Cat 5 Wiring Diagram
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Thiết kế căn hộ Green Hills Bình Tân loại 49m2 gồm 1 phòng ngủ, 1 wc
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