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Public Theater's WILD WITH HAPPY Begins Previews 10/9
The Public Theater (Artistic Director Oskar Eustis and Executive Director Patrick Willingham) will begin previews for the world premiere production of WILD WITH HAPPY, written by Colman Domingo, on Tuesday, October 9 in The Public's LuEsther Theater. Directed by Robert O'Hara, WILD WITH HAPPY runs through Sunday, November 11, with an official press opening on Tuesday, October 23. Tickets are on sale now at (212) 967-7555, www.publictheater.org, or in person at The Public Theater box office.
The complete cast of WILD WITH HAPPY features Colman Domingo (Gil); Korey Jackson (Terry); Maurice McRae (Mo); and Sharon Washington (Adelaide, Aunt Glo).
The Public Theater will also present post-show discussions following select performances with the artists from WILD WITH HAPPY on Wednesday, October 17 and Thursday, October 25. The talkbacks following these performances are included with the price of admission.
From Colman Domingo (a Tony Award nominee for The Scottsboro Boys and an Obie Award winner for Passing Strange) comes a deeply imaginative and utterly outrageous new work that explores the bizarre comedy that lies within death and healing. Gil, an actor who's struggling to carve out his own new life, finds his worlds colliding when his mother dies and he decides to have her cremated. But where should he scatter the ashes? And can he make a fairytale ending for her in the one place that made her wild with happy?
WILD WITH HAPPY features scenic and costume design by Clint Ramos, lighting design by Japhy Weideman, original music and sound design by Lindsay Jones, and projection design by Aaron Rhyne.
ROBERT O'HARA (Director). For The Public, O'Hara has directed The Brother/Sister Plays (Part 2), and Insurrection: Holding History. His Off-Broadway and regional credits include In The Continuum, Eclipsed, Antebellum, A Raisin In the Sun, A Life in the Theater, Man in Love, BootyCandy. He is a recipient of Obie, Helen Hayes, NAACP, and Oppenheimer Awards.
Colman Domingo (Playwright, Gil) has appeared at The Public in Passing Strange and Henry V. Domingo's Broadway credits include Passing Strange, The Scottsboro Boys, Well, and Chicago. His additional Off-Broadway credits include Blood Knot, The Scottsboro Boys, A Boy and His Soul, and Bright Ideas. His select film and television credits include Spike Lee's Red Hook Summer, "The Big Gay Sketch Show," "Law & Order," "Law & Order: Criminal Intent," and "Nash Bridges."
Korey Jackson (Terry) has been seen regionally in Duck Crossing, Five Guys Named Moe, and Dreamgirls. A recent graduate of New York University's Graduate Acting Program at Tisch School for Performing Arts, Jackson's select NYU credits include The Henry Box Brown Play, Sueno, Acquainted with the Night, The Emperor Antony, The Rivals, and Richard III. Jackson has been seen on television in "Law & Order: SVU."
Maurice McCrae (Mo) has appeared in New York in All God's Chillum' Got Wings, American Ma(u)l, and Young Black Men… His regional credits include A House With No Walls, The Piano Lesson, The Ninth Wave, Fences, Cheaters, Soldier's Play, and Jonin.' His television credits include "24," "Guiding Light," "JAG," NYPD Blue," and "Maloney."
Sharon Washington (Adelaide, Aunt Glo) has appeared in The Public Theater Productions of Coriolanus, Cymbeline, Richard III, The Caucasian Chalk Circle, and Before It Hits Home. She has appeared on Broadway in The Scottsboro Boys and Off-Broadway in The Overwhelming, String of Pearls, House, Garden, Seeking the Genesis, The Radical Mystique, and Joined at the Head. Her select film and television credits include Rocksteady, An Invisible Sign, Michael Clayton, Die Hard: With a Vengeance, "Royal Pains," and "Damages."
The revitalization of The Public Theater's downtown home this October will physically manifest The company's core mission of sparking new dialogues and increasing accessibility for artists and audiences by dramatically opening up its landmark building to the street and community, and transforming the lobby into a public piazza for artists, students, and audiences. Designed by Ennead Architects, the project encompasses enhancements to the building's interior and exterior while preserving the historic structure. Key elements of the design include infrastructure updates to the 158-year old building, as well as construction of a new exterior entry stair and glass canopy; installation of ramps for improved accessibility; an expanded and refurbished lobby; the addition of a mezzanine level with a new lounge, designed by the Rockwell Group; expansion and remodeling of restroom facilities; and comprehensive exterior restoration, ensuring stability of the landmark façade.
The only theater in New York that produces Shakespeare and the classics, musicals, contemporary and experimental pieces in equal measure, The Public continues the work of its visionary founder, Joe Papp, by acting as an advocate for the theater as an essential cultural force, and leading and framing dialogue on some of the most important issues of our day. Creating theater for one of the largest and most diverse audience bases in New York City for nearly 60 years, today The company engages audiences in a variety of venues-including Joe's Pub; the Delacorte Theater in Central Park, home to the beloved, free Shakespeare in the Park; and the Mobile Unit, which tours Shakespearean productions for underserved audiences throughout New York City's five boroughs. The Public's wide range of programming includes free Shakespeare in the Park, the bedrock of The company's dedication to making theater accessible to all, new and experimental stagings at The Public at Astor Place, and a range of artist and audience development initiatives including its Public Forum series, which brings together theater artists and professionals from a variety of disciplines for discussions that shed light on social issues explored in Public productions. The Public Theater receives annual support from the New York City Department of Cultural Affairs. www.publictheater.org


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RF Micro Devices (RFMD®) announced plans to expand its compound semiconductor manufacturing capacity to support growth expectations in the company's cellular and multi-market product groups.
RFMD anticipates increased demand for its industry-leading compound semiconductor process technologies as a result of favorable market trends in the company's primary markets. In the cellular handset market, the increasing adoption of highly integrated, multi-chip transmit modules and the migration to 3G multimode devices are expected to drive increased demand for RFMD's GaAs PHEMT and RFMD's GaAs HBT (both AlGaAs HBT and InGaP HBT).
These favorable market trends require greater quantities of compound semiconductor content and are expected to underpin a five-year compound annual growth rate of greater than 20 percent from 2007-2012 in the market for cellular front ends. RFMD was recently recognized as the leading manufacturer of cellular front ends.
Additionally, in markets served by RFMD's Multi-Market products group, it is anticipated the migration to 802.11n (GaAs HBT and GaAs PHEMT) and the increasing adoption of WiMAX (GaAs HBT and GaN) will be among the primary drivers of increased compound semiconductor content and accelerated market growth. RFMD's GaN process technology is quickly being recognized as a superior process technology for applications that require high power, linearity and bandwidth, as compared to existing technologies, such as silicon LDMOS. RFMD is the world's largest manufacturer of GaAs HBT and GaAs PHEMT, and the company is quickly ramping commercial production of its GaN process technology. Asif Anwar, director of Strategy Analytics GaAs and Compound Semiconductor Technologies (GaAs) service, said, "RFMD has consistently been the world's largest supplier of GaAs devices for several years as a result of its leadership in the cellular handset PA space.
The company continues to move in line with the requirements of the cellular handset market, and this will continue to drive the volume at RFMD. RFMD has also developed a coherent multiple market strategy to target higher value segments with the rollout of its GaN and GaAs PHEMT technologies as well as the expansion of its IP and product portfolios through the proposed Sirenza acquisition. This dual 'high volume-high value' strategy will help the company remain at the forefront of the compound semiconductor industry."
Bob Bruggeworth, president and CEO of RFMD, said, "The markets served by RFMD are growing, and RFMD is growing its compound semiconductor content within these markets. The addition of our third fab will enable us to capture a greater percentage of this growth while also reducing manufacturing costs and driving continued improvement in operating profitability.
Once complete, our third fab, in conjunction with our second fab, will focus on high volume cellular and WLAN front end products that utilize GaAs HBT and GaAs PHEMT. The new fab will also provide capacity for the production of wafer-level packaged SAW filters and the development of new, next-generation process technologies that provide highly integrated front end functionality. Our first fab will focus on high value multi-market products that utilize specialty GaN, GaAs PHEMT and GaAs HBT technologies."

subset: commoncrawl


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Rodriguez Receives Linsteadt Technology Transfer Achievement Award, Nov. 20, 2007
by Eva D. Blaylock
Email: email@example.com
ALBUQUERQUE, N.M., November 20, 2006 -- Patrick A. Rodriguez, Director of the Technology Transfer Support Group of the Air Force Research Laboratory's Space Vehicles Directorate , was recently announced the recipient of the 2007 Department of Defense George Linsteadt Technology Transfer Achievement Award.
The award recognizes the efforts of individuals that are involved in technology transfer, as professionals, managers, technologists, principal investigators and patent attorneys, who enable technology transfer from DOD to industry.
Rodriguez, a New Mexico native, has been involved with the Air Force Research Laboratory since 1983 and has been employed as a liaison between research agencies such as the New Mexico Economic Development Department of the New Mexico Research and Development Institute and the New Mexico Institute of Mining and Technology. He is also a former Los Alamos Laboratories employee.
As director of the technology transfer group, Rodriguez is responsible for identifying technological assets and mechanisms that are potential technology transfers to industry, developing strategies and plans to transition identified technologies, aiding other Air Force and DOD organizations with technology transference, and representing the laboratory with various federal, state and local government organizations involved with transfer, utilization and commercialization of technologies.
As stated on Rodriguez's award announcement, from Deputy Under Secretary of Defense John J. Kubricky, "He is being recognized for his career achievements and impact on the Department's Technology Transfer through enabling legislation, as well as his leadership in commercializing the results of the Partnership for Optics. The proliferation of his efforts is a leading example for DOD technology transfer professionals."
Rodriguez was specifically lauded for his personal facilitation of 235 Cooperative Research and Development Agreements with a contribution to the Air Force of approximately $149 million, 11 Patent License Agreements worth $1.2 million, and 215 Educational Partnership Agreements resulting in the transfer of $34 million of used equipment from the laboratory to educational institutions.


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Steve Jobs, in full Steven Paul Jobs, (born February 24, 1955, San Francisco, California, U.S.—died October 5, 2011, Palo Alto, California), cofounder of Apple Computer, Inc. (now Apple Inc.), and a charismatic pioneer of the personal computer era.
Founding of Apple
Jobs was raised by adoptive parents in Cupertino, California, located in what is now known as Silicon Valley. Though he was interested in engineering, his passions of youth varied. He dropped out of Reed College, in Portland, Oregon, took a job at Atari Corporation as a video game designer in early 1974, and saved enough money for a pilgrimage to India to experience Buddhism.
Back in Silicon Valley in the autumn of 1974, Jobs reconnected with Stephen Wozniak, a former high school friend who was working for the Hewlett-Packard Company. When Wozniak told Jobs of his progress in designing his own computer logic board, Jobs suggested that they go into business together, which they did after Hewlett-Packard formally turned down Wozniak's design in 1976. The Apple I, as they called the logic board, was built in the Jobses' family garage with money they obtained by selling Jobs's Volkswagen minibus and Wozniak's programmable calculator.
Jobs was one of the first entrepreneurs to understand that the personal computer would appeal to a broad audience, at least if it did not appear to belong in a junior high school science fair. With Jobs's encouragement, Wozniak designed an improved model, the Apple II, complete with a keyboard, and they arranged to have a sleek, molded plastic case manufactured to enclose the unit.
Though Jobs had long, unkempt hair and eschewed business garb, he managed to obtain financing, distribution, and publicity for the company, Apple Computer, incorporated in 1977—the same year that the Apple II was completed. The machine was an immediate success, becoming synonymous with the boom in personal computers. In 1981 the company had a record-setting public stock offering, and in 1983 it made the quickest entrance (to that time) into the Fortune 500 list of America's top companies. In 1983 the company recruited PepsiCo, Inc., president John Sculley to be its chief executive officer (CEO) and, implicitly, Jobs's mentor in the fine points of running a large corporation. Jobs had convinced Sculley to accept the position by challenging him: "Do you want to sell sugar water for the rest of your life?" The line was shrewdly effective, but it also revealed Jobs's own near-messianic belief in the computer revolution.
Insanely great
During that same period, Jobs was heading the most important project in the company's history. In 1979 he led a small group of Apple engineers to a technology demonstration at the Xerox Corporation's Palo Alto Research Center (PARC) to see how the graphical user interface could make computers easier to use and more efficient. Soon afterward, Jobs left the engineering team that was designing Lisa, a business computer, to head a smaller group building a lower-cost computer. Both computers were redesigned to exploit and refine the PARC ideas, but Jobs was explicit in favouring the Macintosh, or Mac, as the new computer became known. Jobs coddled his engineers and referred to them as artists, but his style was uncompromising; at one point he demanded a redesign of an internal circuit board simply because he considered it unattractive. He would later be renowned for his insistence that the Macintosh be not merely great but "insanely great." In January 1984 Jobs himself introduced the Macintosh in a brilliantly choreographed demonstration that was the centrepiece of an extraordinary publicity campaign. It would later be pointed to as the archetype of "event marketing."
However, the first Macs were underpowered and expensive, and they had few software applications—all of which resulted in disappointing sales. Apple steadily improved the machine, so that it eventually became the company's lifeblood as well as the model for all subsequent computer interfaces. But Jobs's apparent failure to correct the problem quickly led to tensions in the company, and in 1985 Sculley convinced Apple's board of directors to remove the company's famous cofounder.
NeXT and Pixar
Jobs quickly started another firm, NeXT Inc., designing powerful workstation computers for the education market. His funding partners included Texan entrepreneur Ross Perot and Canon Inc., a Japanese electronics company. Although the NeXT computer was notable for its engineering design, it was eclipsed by less costly computers from competitors such as Sun Microsystems, Inc. In the early 1990s Jobs focused the company on its innovative software system, NEXTSTEP.
Meanwhile, in 1986 Jobs acquired a controlling interest in Pixar, a computer graphics firm that had been founded as a division of Lucasfilm Ltd., the production company of Hollywood movie director George Lucas. Over the following decade Jobs built Pixar into a major animation studio that, among other achievements, produced the first full-length feature film to be completely computer-animated, Toy Story, in 1995. Pixar's public stock offering that year made Jobs, for the first time, a billionaire. He eventually sold the studio to the Disney Company in 2006.
Saving Apple
In late 1996 Apple, saddled by huge financial losses and on the verge of collapse, hired a new chief executive, semiconductor executive Gilbert Amelio. When Amelio learned that the company, following intense and prolonged research efforts, had failed to develop an acceptable replacement for the Macintosh's aging operating system (OS), he chose NEXTSTEP, buying Jobs's company for more than $400 million—and bringing Jobs back to Apple as a consultant. However, Apple's board of directors soon became disenchanted with Amelio's inability to turn the company's finances around and in June 1997 requested Apple's prodigal cofounder to lead the company once again. Jobs quickly forged an alliance with Apple's erstwhile foe, the Microsoft Corporation, scrapped Amelio's Mac-clone agreements, and simplified the company's product line. He also engineered an award-winning advertising campaign that urged potential customers to "think different" and buy Macintoshes. Just as important is what he did not do: he resisted the temptation to make machines that ran Microsoft's Windows OS; nor did he, as some urged, spin off Apple as a software-only company. Jobs believed that Apple, as the only major personal computer maker with its own operating system, was in a unique position to innovate.
Innovate he did. In 1998, Jobs introduced the iMac, an egg-shaped, one-piece computer that offered high-speed processing at a relatively modest price and initiated a trend of high-fashion computers. (Subsequent models sported five different bright colours.) By the end of the year, the iMac was the nation's highest-selling personal computer, and Jobs was able to announce consistent profits for the once-moribund company. The following year, he triumphed once more with the stylish iBook, a laptop computer built with students in mind, and the G4, a desktop computer sufficiently powerful that (so Apple boasted) it could not be exported under certain circumstances because it qualified as a supercomputer. Though Apple did not regain the industry dominance it once had, Steve Jobs had saved his company, and in the process reestablished himself as a master high-technology marketer and visionary.
Reinventing Apple
In 2001 Jobs started reinventing Apple for the 21st century. That was the year that Apple introduced iTunes, a computer program for playing music and for converting music to the compact MP3 digital format commonly used in computers and other digital devices. Later the same year, Apple began selling the iPod, a portable MP3 player, which quickly became the market leader. In 2003 Apple began selling downloadable copies of major record company songs in MP3 format over the Internet. By 2006 more than one billion songs and videos had been sold through Apple's online iTunes Store. In recognition of the growing shift in the company's business, Jobs officially changed the name of the company to Apple Inc. on January 9, 2007.
In 2007 Jobs took the company into the telecommunications business with the introduction of the touch-screen iPhone, a mobile telephone with capabilities for playing MP3s and videos and for accessing the Internet. Later that year, Apple introduced the iPod Touch, a portable MP3 and gaming device that included built-in Wi-Fi and an iPhone-like touch screen. Bolstered by the use of the iTunes Store to sell Apple and third-party software, the iPhone and iPod Touch soon boasted more games than any other portable gaming system. Jobs announced in 2008 that future releases of the iPhone and iPod Touch would offer improved game functionality. In an ironic development, Apple, which had not supported game developers in its early years out of fear of its computers not being taken seriously as business machines, was now staking a claim to a greater role in the gaming business to go along with its move into telecommunications.
Health issues
In 2003 Jobs was diagnosed with a rare form of pancreatic cancer. He put off surgery for about nine months while he tried alternative medicine approaches. In 2004 he underwent a major reconstructive surgery known as the Whipple operation. During the procedure, part of the pancreas, a portion of the bile duct, the gallbladder, and the duodenum were removed, after which what was left of the pancreas, the bile duct, and the intestine were reconnected to direct the gastrointestinal secretions back into the stomach. Following a short recovery, Jobs returned to running Apple.
Throughout 2008 Jobs lost significant weight, which produced considerable speculation that his cancer was back. (The average survival rate for patients who underwent Whipple operations was only 20 percent at five years.) Perhaps more than those of any other large corporation, Apple's stock market shares were tied to the health of its CEO, which led to demands by investors for full disclosure of his health—especially as the first reasons given for his weight loss seemed insufficient to explain his sickly appearance. On January 9, 2009, Jobs released a statement that he was suffering from a hormonal imbalance for which he was being treated and that he would continue his corporate duties. Less than a week later, however, he announced that he was taking an immediate leave of absence through the end of June in order to recover his health. Having removed himself, at least temporarily, from the corporate structure, Jobs resumed his previous stance that his health was a private matter and refused to disclose any more details.
In June 2009 the Wall Street Journal reported that Jobs had received a liver transplant the previous April. Not disclosed was whether the pancreatic cancer he had been treated for previously had spread to his liver. The operation was performed in Tennessee, where the average waiting period for a liver transplant was 48 days, as opposed to the national average of 306 days. Jobs came back to work on June 29, 2009, fulfilling his pledge to return before the end of June. In January 2011, however, Jobs took another medical leave of absence. In August he resigned as CEO but became chairman. He died two months later.
Learn More in these related Britannica articles:
computer: Apple Inc.Wozniak and Steven P. Jobs, shared an interest in electronics. Wozniak was an early and regular participant at Homebrew Computer Club meetings (
seethe earlier section, The Altair), which Jobs also occasionally attended.…
Internet: Two agendas…that Apple's two young founders—Steven Jobs and Stephen Wozniak—worked as interns in the Stanford University Artificial Intelligence Laboratory and at the nearby Hewlett-Packard Company. The Bay Area's counterculture also figured prominently in the PC's history. Electronic hobbyists saw themselves in open revolt against the "priesthood" of the mainframe computer…
Apple Inc.: Garage start-up…a former high-school classmate, 21-year-old Steven P. Jobs, moved production operations to the Jobs family garage—and the Silicon Valley garage start-up company legend was born. Jobs and Wozniak named their company Apple. For working capital, Jobs sold his Volkswagen minibus and Wozniak his programmable calculator. Their first model was simply…
Steve Wozniak…American electronics engineer, cofounder, with Steve Jobs, of Apple Computer, and designer of the first commercially successful personal computer.…
Pixar Animation Studios…was acquired by Apple cofounder Steve Jobs, then the head of the computer firm NeXT Inc. Catmull became president and CEO of the new company, called Pixar, and Jobs was installed as chairman of the board. Initially, Jobs steered the company's efforts toward marketing the Pixar Image Computer and developing…
More About Steve Jobs7 references found in Britannica articles
Assorted References
- Apple Inc.
- Cook
- In Tim Cook
- Internet
- iPod
- In iPod
- personal computers
- Pixar Animation Studios
- Wozniak


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By Christine Hinrichs
After months of TV watching, countless cheers and upsets, and numerous football parties, the Super Bowl is finally here. And with the Patriots and the Giants meeting for their second Super Bowl matchup in the last few years, it's sure to be a great game. I enjoy having Super Bowl parties, but what I really love is creating theme recipes. Here are two recipes, one for New York fans and one for Patriots fans, and both are easy to put together and are sure to impress your guests.
New England Chowder with Old Bay Croutons
(serves 6-8 as a regular entrée)
adapted from Epicurious
If you don't like clams, feel free to omit the clams and then substitute vegetable stock for the clam juice. For a more festive feel, serve the chowder in shot glasses!
- 2 tablespoons unsalted butter
- 1 ¼ pound canned clams, minced, juice reserved
- 2-3 cups clam juice OR 3 cups of vegetable stock
- 1 yellow onion, diced
- 1 tablespoon all-purpose flour
- ½ teaspoon fresh thyme, chopped
- 3 large russet potatoes, peeled and diced
- ½ cup frozen corn
- 2 cups half and half
- 1 tablespoon dry white wine
- ½ teaspoon Worcestershire sauce
- 1 teaspoon Old Bay seasoning
- Salt & pepper to taste
- 1 baguette, diced into 1-inch cubes
- 1-2 tablespoons extra virgin olive oil
- 2-3 teaspoons Old Bay seasoning
Preheat your oven to 400 degrees. Combine the clam juice and juice from canned clams until you have 3 cups of liquid.
In a large soup pot, melt the butter over medium heat. Once melted, add the onion and cook until translucent and tender, about 5-7 minutes. Add the flour and cook over low heat, stirring, for another 2 minutes.
Whisk in the clam juice, bring to a simmer and cook for 5 minutes. Add the thyme and 1 teaspoon of Old Bay seasoning. Add the diced potatoes and simmer partially covered until the potatoes are tender.
In a separate sauce pan, combine the minced clams and half and half and simmer until clams are cooked through. Once the potatoes are tender, add the clam mixture to the soup pot and the frozen corn. Simmer together for another few minutes. Stir in the wine and Worcestershire sauce, taste and adjust salt & pepper.
Meanwhile, toss the cubed bread, olive oil, and Old Bay seasoning. Arrange the bread cubes on a baking sheet lined with parchment paper in a single layer. Bake until the bread is crisp but still has some give, about 5-8 minutes. Serve the chowder in small bowls or shot glasses and top each serving with Old Bay croutons.
Christine Hinrichs is a vegetarian who loves everything related to food. She daydreams about recipes, frequents the local farmers' markets, and reads cookbooks before bed. Read about her food adventures at ruminationsonfood.blogspot.com.
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Remember game 1, when the way to beat the Hawks was blitz, blitz, blitz? The report was out on Wilson, the Cards showed the league what to do, and Wilson faced so much blitzing in the following weeks that if he hadn't been such a slippery squirrel, he would have been road kill. How times have changed.
Against the Vikings, he only faced 8 rushes of 5 or more guys. Why? He was killing the blitz. He was 5 for 8 for 45 yards and two touchdowns vs the blitz.
And he never even smiled while he was doing it.


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Organize It: Vintage Blue Drawers & Boxes
When considering storage solutions, instead of buying new, try vintage blue! These steel cabinets and boxes add a warm industrial look to your style, and their pre-owned condition makes them an easy way of being eco-friendly. Better yet, their compact size and rectangular shape are space efficient, making them easy to blend with modular pieces.
To get vintage pieces shining, give it a good wipe down. Two passes with a cleaning spray and cotton rags does a solidly good job.
Shown above from left to right:
1. Industrial Blue 18 Drawer Parts Cabinet, $325.00 from Old Soul VTG
2. Vintage Steel Blue Boxes, $45.00 from Retrograde LA
3. Tall Blue Industrial Cabinet with Drawers - 40 drawers, $28.00 from Skippi Diddle
4. Metal Box Storage File - Porta File, $12.50 from Naya Studio
5. Vintage Blue Tool Box - Craft Organizer with Handle, $14.00 from My Vintage Fix
• A Sensational Silver, Blue & White Palette for a Fashion Forward Kitchen
• Curvy Blue Bathroom from Porcelanosa
(Images: As credited above.)


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NEW DELHI – He was a slight young man, who sported hipster eyeglasses and a wispy moustache. He had dyed his spiky hair blond, but that wasn't the only thing that made college student Nido Tania stand out in the Indian capital.
Tania was from northeastern India, a narrow strip of territory wedged between China and Myanmar, whose people say they face discrimination here for having "Asian" facial features. When Tania, 20, stopped in a dairy to ask for directions Tuesday afternoon, a shopkeeper's taunt about his hair color quickly escalated into a violent altercation in which several men thrashed him with sticks and steel rods, friends say.
He died in his bed the next day, succumbing to severe injuries to the chest and brain, according to preliminary medical results provided to his family.
The incident has sparked fresh outrage in New Delhi, which was already reeling from a spate of high-profile rape cases, and has added to a growing sense of insecurity in a capital that is aiming to be a showcase for India's growing economic might.
Hundreds of protesters rallied Saturday in Lajpat Nagar, the bustling market where the beating took place, calling it a hate crime and demanding that the assailants be prosecuted.
"This happens every day in Delhi. Each and every one of us has experienced discrimination because of our physical features," said Sophy Chamroy, a 22-year-old student from the northeastern state of Manipur.
India's 1.2 billion people comprise a vast tableau of languages and customs but – as with the rape cases – racially motivated assaults seem to occur in New Delhi and other major cities with grim regularity. Many victims from the northeast are young people who have migrated to the capital for school or job opportunities lacking in their poorer home areas.
Last year in New Delhi, three students from Manipur were brutally beaten by neighbors. In a separate case, a 21-year-old beautician from Manipur was found dead in her apartment with severe injuries to her face and toes. Police labeled it a suicide and dropped the case but many suspected she was slain.
So widespread is the discrimination against people from northeastern India that the federal government in 2012 passed a law that punishes the use of a racial slur with up to five years in prison. Still, activists say, authorities rarely enforce such laws and police are as likely to participate in discrimination as intervene to stop it.
"You don't know what is on the minds of people in Delhi, because these incidents keep on recurring," said Geetartha Barua, an official with the state government of Arunachal Pradesh, where Tania lived.
He was in New Delhi on vacation and going to visit an ailing friend in the area near Lajpat Nagar when he walked into the dairy Tuesday afternoon, friends said. According to Barua, the dairy shopkeeper taunted Tania for not knowing his way around, saying, "Are you from China?" and making fun of his hair.
Tania smashed a glass display case in anger, prompting the shopkeeper and several other men from the market to set upon him and a friend. The shopkeepers called the police, who got Tania to pay about $120 for the broken glass but did not take any action against the assailants, Barua said.
Police officers let Tania go, but when he passed the shop a second time the attackers beat him again, said Jotam Toko Tagam, the former president of a New Delhi organization for students from Arunachal Pradesh. When he reached his sister's apartment, where he was staying, he complained of heavy pain and was bleeding badly from his wrist, but he fell asleep early Thursday morning after applying balms across his body, Tagam said.
Around 1 p.m. the next day, friends tried to wake him but found his body cold and limp. Brought to a nearby hospital, he was pronounced dead on arrival, Barua said.
The case sparked a swift outcry across Indian media and websites Friday, with many criticizing the response by the Delhi police. Three men reportedly have been detained for questioning, but Barua said police didn't open a murder investigation until 24 hours after Taniam died, after the incident had begun to make national news.
"We are being forced to go exert pressure on different quarters to get the police to investigate this matter properly, at a time when the situation is very sad," Barua said. "The response from the police side has not been encouraging."
Tania's body was flown home Saturday morning to Arunachal Pradesh, where his father is a lawmaker in the state legislature.
Twitter: @SBengali
Tanvi Sharma in The Times' New Delhi bureau contributed to this report.


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UNIVERSITY PARK, Pa. — The tour of the smash hit Broadway revival of "West Side Story" comes to the Center for the Performing Arts at Penn State for one performance at 7:30 p.m. Tuesday, Nov. 19, in Eisenhower Auditorium.
The show is sold out, but a few tickets might become available as the date of the presentation nears. For ticket availability, call the Arts Ticket Center at 814-863-0255 or 800-ARTS-TIX.
"West Side Story" tells the story of star-crossed lovers Tony and Maria as they struggle to rise above the hatred and intolerance that surrounds them. "West Side Story" soars as one of the greatest love stories of all time and remains as powerful, poignant and timely as ever.
The Leonard Bernstein and Stephen Sondheim score is considered one of Broadway's finest and features such classics of the American musical theater as "Something's Coming," "Tonight," "America," "I Feel Pretty" and "Somewhere."
The show "remains Broadway's best dance-driven musical," wrote an Associated Press critic. "Five decades have not dimmed the extraordinary choreography or the score that pulsates throughout."
"The true stars of 'West Side Story' are Jerome Robbins' graceful, endlessly expressive choreography and Leonard Bernstein's score, which still sounds bracingly modern a half-century after it was first heard," wrote a reviewer for Variety. "The music is a primal force."
Three theatrical luminaries created West Side Story: two-time Tony Award winner Arthur Laurents (book) and multiple Tony and Grammy award winners Bernstein (music) and Sondheim (lyrics).
"West Side Story" features scenic designs by James Youmans, costumes by Tony Award nominee David C. Woolard, lighting by Tony Award winner Howell Binkley and sound design by Peter McBoyle.
The show is recommended for ages 13 and older. It includes strong language, violence and some sensitive subject matter true to the story. Parental guidance is suggested. A small portion of the lyrics and dialogue in this revival production are in Spanish. It's not necessary to understand Spanish to comprehend the story.
Audio description, which is especially helpful to patrons with sight loss, is available for this performance at no extra charge to ticket holders.
Artistic Viewpoints, an informal moderated discussion featuring two "West Side Story" cast members, will be offered in Eisenhower one hour before the performance and is free for ticket holders. Artistic Viewpoints regularly fills to capacity, so seating is available on a first-arrival basis.
Kish Bank sponsors the presentation. FOX 8 and ABC 23 are the media sponsors.
Find the Center for the Performing Arts on Facebook at http://www.facebook.com/pscpa.


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St. Katherine YAL Sandwich Making for the Homeless
Please join us on Tuesday, June 5, 2018 for our monthly Deuteri Deutera sandwich-making for the homeless event at 7:30 PM in the kitchen of the Meletis Charuhas Center.
The sandwiches that we make will be delivered to the Bailey's Crossroads Shelter in Falls Church that same evening. The shelter is thankful to receive our help each month, as they serve many local men and women in need of our contributions!


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The YMCA of Central Ohio is collaborating with the South-Western City School District to offer programs at four district schools this summer that combine reading and academic enhancement with youth enrichment activities.
The YMCA of Central Ohio is collaborating with the South-Western City School District to offer programs at four district schools this summer that combine reading and academic enhancement with youth enrichment activities.
"We've done programs for the district in the past, but this is the first time we've done a full-blown program that intertwines enrichment activities during the afternoon and an academic-based literacy program in the morning," said Nancy Brody, metropolitan school-age quality education research director for the YMCA.
The program originally was slated for Stiles Elementary School only, Brody said.
The Stiles sessions are being funded through a $30,000 grant from Y in the USA, the YMCA's national organization, she said.
"Stiles was selected for this program because of a combination of being a low-income school with a very high rate of free and reduced(-price) lunches plus a large number of English as a Second Language students," Brody said.
The school district asked if the YMCA would be willing to help organize summer programs at three other schools: Harmon and Prairie Lincoln elementary schools and Franklin Woods Intermediate School, she said. The activities at those three schools are being funded by the school district.
The YMCA has hired district teachers to conduct the morning educational sessions while Y employees mostly handle the afternoon enrichment program, Brody said.
At the elementary schools, students in kindergarten and first grade spend the morning working on their reading, writing and math skills, she said.
The reading work is designed in part to help students prepare for being able to meet the state's new third-grade reading guarantee and/or to keep their reading skills from falling behind while school is out for the summer, Brody said.
ESL students also are able to work on improving their English speaking skills, she said.
"We're trying to keep students and their teachers from having to take time at the start of the school year to catch up after the long summer," Brody said.
Students entering the fourth and fifth grades also are working to improve and maintain their reading skills at Franklin Woods, she said.
In the afternoon, students participate in a variety of enrichment activities, including swimming lessons, educational field trips, lessons on health and nutrition and at least one hour a day of physical fitness activities.
The summer program has run each Monday through Thursday since June 24 and will end today, Aug. 1.
"I was just out at Stiles and what's great is that the staff members and the children are so enthusiastic," Brody said. "Every staff member I spoke to asked if we could please, please do this program again next year. We'd love to do it again, but it will depend on whether funding is available."
"We've been able to include a lot of fun activities, both in the morning and afternoon, so the kids don't feel like they're spending the summer at school," said Mary Schneider, the YMCA's child-care director.
The food and nutrition aspect of the program is perhaps as important as the educational and fitness components, she said.
"The children are learning about the importance of eating healthy," Schneider said. "Some of them didn't realize, for example, how important it is to drink a lot of water."
Students receive two nutritious meals and a snack at the program each day, she said.
"The staff members say they can tell some of these kids, especially on Monday after the weekend, are hungry and perhaps haven't been able to have a complete meal at home," Schneider said.
Elana Lenihan, assistant child-care director, helps to oversee the Stiles program and said she has been thrilled with the youngsters' enthusiasm.
"The kids are so excited to learn," she said early this week. "We will not be doing our testing until (July 31), but I think it's certain we'll see some real educational benefits for the students."
A total of 146 students have participated in the program at the four schools, Brody said. The program also has been open to students from other district schools located near the host sites.


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Diane Culhane Art
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Materials: Acrylic paint, ink & pencil on canvas
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Description: All four sides of this 4"x4"x1.5"canvas is painted. This is a continuation of the composition wrapping around all the edges; giving side views for a completion of the story.


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Table of Contents
> Protein Truncation Test (PTT)
Protein Truncation Test (PTT)
Related terms
Future research
Author information
Related Terms
Autoradiography, biotin labeling, chemiluminescence, colorimetry, electrophoresis, ELISA-PTT, epitope tags, fluorescent detection, FluoroTagsT tRNAs,
in vitro
translation, mutation detection, mutation scanning, nonisotopic detection, phosphorimaging, protein truncation test, PTT, SDS-PAGE, truncation mutations, tumor suppressor genes, Western blot.
Genes, which are made of deoxyribonucleic acid (DNA), are considered the building blocks of life because they provide instructions for cells in the body. They are located inside cells and they control an organism's development and function by instructing cells to make new molecules (usually proteins). Genes are passed down from parents to their offspring (children).
DNA is a long thread-like (double-helix) molecule made up of large numbers of nucleotides. The sequence of bases in DNA serves as the carrier of genetic (hereditary) information. Nucleotides are the building blocks of DNA and are made of nitrogen bases, sugars, and phosphate. Nitrogen bases are of two types: purines, such as adenine (A) and guanine (G), and pyrimidines, such as cytosine (C) and thymine (T). Long strands of nucleotides form nucleic acids. Ribonucleic acid (RNA) is a nucleic acid that helps in protein synthesis, which is important for the growth and maintenance of the body. RNA is formed under the direction of DNA and both help to form amino acids, which are the building blocks of protein.
A mutation is a change in the sequence of base pairs in the DNA that makes up a gene. "Base pairs" refers to a pair of nitrogen bases such as adenine-thymine and guanine-cytosine in DNA and adenine-uracil and guanine-cytosine in RNA. A nonsense mutation may result in a truncated and, in many cases, nonfunctional protein. Some mutations may influence the risk of developing certain disorders/diseases. For example, mutations on the BRCA1/BRCA2 genes are associated with the development of breast and ovarian cancers.
Protein translation is a process by which the genetic code carried by messenger RNA (mRNA) directs the production of proteins from amino acids, the building blocks of proteins. This process is also known as RNA translation. mRNA is a form of RNA that carries information from DNA in the nucleus to the ribosomes within the cytoplasm of the cell, which are the sites of protein synthesis.
The protein truncation test (PTT) is a simple, fast, and efficient technique that is accurate provided that quality control is maintained. The technique screens for biologically relevant gene mutations (mutation detection), which cause an early stop to the process of protein translation which leads to incomplete and nonfunctional proteins. Certain incomplete and nonfunctional proteins may lead to the development of a disease/disorder. For example, the duchenne muscular dystrophy (DMD) gene provides instructions for the making of (encodes) the protein dystrophin. Dystrophin is an important component of muscles and provides structural stability. Certain mutations in the DMD gene may result in incomplete or nonfunctional dystropin, thereby causing the disease DMD, a rapidly progressive degenerating disease of muscles that is eventually fatal as a result of the weakening of respiratory and heart muscles.
PTT may have a wide diagnostic application in identifying the disease-causing mutations due to premature protein translation termination. Some of the conditions include breast cancer, cancer of the large intestine and rectum, bladder cancer, polycystic kidney disease (multiple cysts in kidney leading to kidney failure), Duchenne muscular dystrophy (DMD; a rapidly progressive degenerating disease of muscles), neurofibromatosis (growth of tumors along nerves in the skin, brain, and other parts of the body and skin pigmentation), and tuberous sclerosis (non-cancerous growth of tumors in skin, brain, kidney, and other organs).
PTT was first reported in 1931 and was used chiefly in the field of clinical research and did not have wide acceptance due to several limitations in its original method. However, with recent advances and modifications, PTT has evolved considerably from its original form and is the preferred mutation scanning technique applied on a protein level.
Protein truncation test method (PTT) is based on detection and size analysis of prematurely terminated translation of protein products resulting from
in vitro
(a test performed in a test tube in laboratory) transcription and translation of the coding sequences. These coding sequences are derived from the amplification (increase in number) of DNA/RNA samples by polymerase chain reaction (PCR).
Transcription is a process by which messenger RNA (mRNA) is synthesized from a DNA template (pattern) resulting in the transfer of genetic information from the DNA molecule to the mRNA. This process is also called DNA transcription. This is different from translation, which is a process by which the genetic code carried by mRNA directs the production of proteins from amino acids, the building blocks of proteins.
PCR is an efficient and sensitive laboratory technique to amplify (produce multiple copies) a specific sequence of DNA into billions of its copies in the presence of sequence specific oligonucleotide primers and DNA polymerase enzyme. An oligonucleotide primer is a sequence of nucleotides, usually of 20-50 bases that is complementary to a specific DNA sequence and serves as a starting point for DNA replication/multiplication. DNA polymerase is an enzyme that synthesizes new DNA strands using preexisting DNA strands as a template, thereby assisting in DNA replication.
Steps involved in the protein truncation test
Genomic RNA or DNA is extracted from the sample of interest (blood, cell culture) and purified. Usually RNA is used as an amplification template and DNA is used in few cases (e.g., BRCA1 gene, FAP gene, etc.). RNA samples are preferred as they contain the exons. Exons are sequences of DNA in a gene that contain information (codes) for protein formation (synthesis) that are transcribed to mRNA. Introns are intervening sequences in a gene situated between exons and they do not code for protein synthesis. During the transcription process, the introns from the DNA get removed (spliced) and the mRNA has only the exons. The mRNA with only exons is then translated into proteins.
The purified genomic DNA with large exons (>2kb or kilobase) may be amplified using PCR and genomic sequences containing RNA use reverse transcriptase PCR (RT-PCR). RT-PCR is a technique that involves the synthesis of complementary DNA (cDNA) from RNA by reverse transcription (the opposite of transcription i.e., synthesis of DNA under the direction of RNA). cDNA is a single stranded DNA that is complementary to mRNA. This is followed by the amplification of cDNA by PCR.
The nucleic acids (DNA/RNA) have two ends of the strand as 5' (5 prime) end and 3' end. The 5' is called a 'leader' end and 3' is known as a 'trailer' end. Specifically designed primers are used to incorporate a T7 RNA polymerase (RNAP) promoter at the 5' (5 prime) end, as the amplified product is further utilized for
in vitro
transcription and translation. T7 RNAP is an enzyme that catalyzes (helps in a chemical/biological reaction) to form a RNA copy of DNA or RNA template.
The amplified PCR or RT-PCR product is used as the starting material for
in vitro
translation and the resulting protein is analyzed by gel electrophoresis. Electrophoresis is a technique that uses electrical current to separate and analyze proteins (also DNA and RNA) by electrical charge. Gel electrophoresis separates the molecules by molecular weight and charge. The product is probed/checked with specific complementary sequences to the target sequence and tagged with fluorescent markers, facilitating easy detection. FluoroTagsT tRNAs are fluorescently labeled and may eliminate the need for radioactivity in research and diagnostic tests.
In the conventional PTT method, the translated protein products are analyzed by SDS-PAGE followed by autoradiography or phosphorimaging. Sodium docecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) is a protein electrophoresis method that separates the proteins based on their electric charge, molecular weight and structure (complex structure of amino acids and carbon, hydrogen, nitrogen etc.). These proteins are labeled (attached) with radioactive molecules that may be visualized by autoradiography, which develops film exposed to radiation (similar to an X-ray). Phosphorimaging is a technique similar to, but much more accurate than autoradiography, and is used to visualize the molecules and fragments labeled with radioactive molecules by analyzing them electronically with the help of a computer.
The recently modified PTT uses the ELISA (enzyme linked immunosorbent assay) based non-radioactive method to detect the truncated proteins (incomplete and nonfunctional proteins) and/or Western blotting. ELISA is a sensitive method to detect an antigen or an antibody linked to an enzyme as a marker for the detection of specific proteins. An antigen is any substance, such as a virus, bacterium, toxin, or foreign protein, which triggers an immune system response in the body. The immune response is in the form of proteins that are specific to an antigen and are known as antibodies or immune bodies. Western blotting is a technique used to identify and locate proteins based on their ability to bind to specific antibodies. The ELISA and Western blotting techniques do not use radioactive molecules, which require special handling with skilled persons and suitable precautions as they may cause cancer.
A biotinylated Lysine-tRNA is used to incorporate biotin label in the protein during the
in vitro
translation step. tRNA (transfer RNA) carries amino acids to the ribosome (a cell organelle that carries out protein synthesis) for protein synthesis. The biotinylated Lysine-tRNA is a process where the biotin (vitamin H) gets tagged (attached) to the truncated protein during its synthesis in translation for easy detection.
The biotin-labeled translated proteins are visualized by chemiluminescence, colorimetry, or fluorescent detection methods. The chemiluminescence method uses a chemical dye that binds with the biotin and the chemical reaction emits light, which is detected by a luminescent imager. Similarly, in the colorimetric detection method, a colored staining reagent such as BM teton may be detected by colorimeter. In the fluorescent detection method, fluorescent dyes, such as HNPP (2-hydroxy-3-naphthoic acid-2'-phenylanilide phosphate), are detected by ultra-violet (UV) illumination.
: The advantageous features of PTT include pinpointing the site of mutation, high sensitivity and specificity, low false positive rate, and most importantly, highlighting the disease-causing mutations. Specificity refers to the distinguishing quality or accuracy of the test to detect mutations and sensitivity indicates the probability of a test to correctly identify the mutation of single base pairs in a sequence. The false positive rate is the proportion of negative instances that were erroneously reported as being positive for a mutation.
Other techniques to detect mutations that may cause premature (earlier than predicted) termination (ending) of protein translation leading to incomplete and nonfunctional proteins include single strand conformation polymorphism (SSCP) analysis, heteroduplex analysis, and denaturing gradient gel electrophoresis (DGGE). SSCP analysis involves electrophoretic separation of single-stranded nucleic acids based on the difference in a single base pair (mutation). Heteroduplex analysis involves the mixing of test DNA and wild-type DNA (normal or reference DNA), followed by heating to melt the duplex (denature), then cooled to reanneal (joined) the duplex. Any difference between two DNA sequences leads to the formation of DNA mismatch (heteroduplex DNA), which may be detected on gel electrophoresis. The DGGE analysis involves the separation of DNA fragments based on sequence differences that result in different denaturing characteristics of the DNA, when run on a gel with increasing concentrations of chemical denaturants. These techniques are time-consuming and labor-intensive in comparison to PTT and do not pinpoint the disease-causing mutations.
The protein truncation test has gained widespread use not only in the clinical and diagnostic laboratories, but also in research applications such as producing intact or truncated proteins for protein-protein interactions, protein-nucleic acid interactions, biochemical analysis, epitope mapping (using epitope tags), and various others. Epitope mapping refers to the process of identification and characterization of proteins so as to find the compatible proteins and antibodies that bond with each other.
New gene mutations are being detected in inheritable conditions such as epidermolysis bullosa (a genetic disorder with fragile skin resulting in blister formation from minor mechanical friction as in rubbing of skin) and ataxia-telangiectasia (an immune disorder characterized by abnormalities of balance, enlarged blood vessels in the eyes and skin surface, and are prone to certain cancers).
The protein truncation test (PTT) has found wide applications, especially in the detection of various disease-/disorder-causing mutations, which may help with prevention or early detection of disease. PTT may enable accurate prenatal (during pregnancy) diagnosis for families who are at high risk of having further affected children (parents carry a copy of a mutated gene and there is a chance of that mutation being passed on to their children). Some of the examples are described below.
Mutations on the BRCA1/BRCA2 genes are associated with the development of breast and ovarian cancers. Detection of these mutations may help to identify the persons who may be at risk for developing these cancers, especially among cancer prone families and in certain population groups. Most of the mutations on BRCA1 and BRCA2 genes associated with breast and ovarian cancer result in shortened and nonfunctional proteins. Detection of these truncated proteins aids in the early detection of breast and ovarian cancers.
Alterations in the APC (adenomatous polyposis coli) gene are associated with familial adenomatosis polyposis (FAP), an inherited condition where the affected person is prone to develop intestinal cancer (colon and rectum). APC protein regulates cell division and prevents cellular overgrowth (tumor suppression). Most of the mutations on the APC gene result in the production of an abnormally short, nonfunctional version of the APC protein, which may lead to polyp formations that could become cancerous. Polyps are the fleshy growth on the inside wall of the intestine. Typically, the affected person may begin to develop polyps as early as in the teen years and the polyps may become cancerous by the age of 40, unless treated. Hence, the early detection in the family members of the affected person for these altered proteins by PTT, which are associated with the development of polyps, aids in timely prevention and control of FAP.
A mutation in the DMD or dystrophin gene is associated with the development of Duchenne muscular dystrophy, a rapidly progressive degenerating disease of muscles that is eventually fatal as a result of the weakening of respiratory and heart muscles.
Inheritable polycystic kidney disease is caused by mutations in the PKD1 and PKD2 genes. These genes provide instructions for making proteins, which are essential for normal development, organization, and function of the kidneys. Early detection of these mutations may help prevent and control the disease.
The neurofibromin 1 (NF1) gene provides instructions for making neurofibromin proteins, which act as tumor suppressor proteins for uncontrolled growth of nerve cells. A mutation in the NF1 gene may lead to nonfunctional and incomplete neurofibromin protein, which is associated with the development of neurofibromatosis. Neurofibromatosis is a disease condition characterized by skin pigmentation and growth of tumors along nerves in the skin, brain, and other parts of the body that may become cancerous.
Other conditions, such as tuberous sclerosis (non-cancerous growth of tumors in skin, brain, kidney, and other organs) caused by mutations on either the TSC1 and TSC2 genes and choroideremia (degenerative disease of the eye leading to vision loss which mostly affects males), which is caused by a mutation in the CHM gene on the X chromosome that codes for the Rab escort protein 1 (REP1), may be detected and diagnosed with the help of PTT.
Limitations of the protein truncation test (PTT) include technical issues related to the use of ribonucleic acid (RNA) and stability of the transcripts derived from the two alleles present. RNA is fragile and easily damaged or degraded by ribonucleases, a RNA cutting enzyme.
Slow readout may be another limitation; it takes a relatively long time (usually 1-2 days) for the protein migration and separation because of the use of electrophoresis followed by radioactive detection, another time-consuming procedure.
The radioactive detection materials should be handled with care. Persons using any radioisotope must be well trained in their safe use and facilities should be available for the safe disposal of radioisotopic and contaminated materials. Exposure to radiation may increase the person's susceptibility to develop cancer.
These limitations on the conventional PTT method have been overcome by the use of high throughput based PTT using biotin labeled chemiluminescence, colorimetry, or fluorescent detection methods.
Future research
The application of the protein truncation test (PTT) is not restricted to the detection and diagnosis of new mutations and their related diseases, but also may contribute towards understanding how these changes cause the disease and imparting knowledge for finding potentially effective and lasting treatments (such as gene therapy) for these disease conditions. For example, mutations in the dystrophin gene are associated with the development of Duchenne muscular dystrophy (DMD), a rapidly progressive degenerating disease of muscles that is eventually fatal as a result of the weakening of respiratory and heart muscles. Progressive research to treat this condition using gene therapy is currently being done.
Author information
This information has been edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
Basurto-Islas G, Luna-Munoz J, Guilloznet-Bongaarts AI et al. Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease. J Neuropathol Exp Neurol. 2008 May;67(5):470-83.
Du L, Lai CH, Concannon P et al. Rapid screen for truncating ATM mutations by PTT-ELISA. Mutat Res. 2008 Apr 2;640(1-2):139-44. Epub 2008 Jan 31.
Gites S, Lim M, Carlson R et al. A high-throughput nonisotopic protein truncation test. Nat Biotechnol. 2003 Feb;21(2):194-7. Epub 2003 Jan 13. Erratum in: Nat Biotechnol. 2003 Sep;21(9):1098.
Hauss O, Muller O. The protein truncation test in mutation detection and molecular diagnosis. Methods Mol Biol. 2007;375:151-64.
Kahmann S, Herter P, Kuhnen C et al. A non-radioactive protein truncation test for the sensitive detection of all stop and frameshift mutations. Hum Mutat. 2002 Feb;19(2):165-72.
Natural Standard: The Authority on Integrative Medicine. .
Roest PA, Roberts RG, Segino S et al. Protein truncation test (PTT) for rapid detection of translation-terminating mutations. Hum Mol Genet. 1993 Oct;2(10):1719-21.
Soukupova J, Dundr P, Kleibl Z et al. Contribution of mutations in ATM to breast cancer development in the Czech population. Oncol Rep. 2008 Jun;19(6):1505-10.
Vossen R, den Dunnen JT. Protein truncation test. Curr Protoc Hum Genet 2004 Sep;Chapter 9:Unit9.11.
Copyright © 2011 Natural Standard (
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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Stackable chair with four-leg base frame, in talc filled polypropylene with closed backrest, with or without armrests. It's available in 5 different colors and can be used also outdoor.
Juno is the latest seating system by James Irvine for Arper. With Juno, plastic chair has come of age. Cast in a single form, it has fluid lines and a light profile: in silhouette, weight and impact. It enjoys all the benefits of simplicity and uniformity but with a clever twist. Juno brings efficiency and customization together in unique combination. Compared to other single-shot molded plastic chairs, Juno features an extremely varied range of configurations: this singular, simple shape available in five colors with closed or open back and arm rests can also be customized with sleek upholstered seat and back rests. Made for both residential and contract use, indoors and out, Juno is available in 4 forms: solid back and open back, both with and without arm rests. All forms are available in 5 colors: white, sand, anthracite, orange, yellow. Seat and back rests can be finished in upholstered pads. All variations are stackable to allow for large-scale use and storage. Red Dot Product Design Award, Germania 2013 iF Product Design Award, Germania 2013 Winner of Design Guild Mark ADI Design Index 2013 German Interior Innovation Award 2014 Designed by James Irvine in collaboration with Arper, Juno is a sleek and minimal chair compatible with home, office and outdoor environments. For 2014, Arper will begin fabrication of this contemporary design in a new plastic that has been fortified by fiberglass, lending a sturdiness to its clean form. A newly engineered linking system makes Juno ideal for stacking and stowing. Juno's alluring silhouette is available with optional armrests and open or closed backrests.
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1. Pace
Draw out the positive phase of each exercise (lifting or pushing) for 4 seconds, and the negative phase (lowering or resisting the weight) for 6 seconds. Do each move without stopping for 2 minutes, but if your muscles give out sooner, rest for a few seconds and continue for the remaining time.
2. Weight
Even small dumbbells can get very heavy when you're lifting and lowering so deliberately. Start with 3- or 5-pound weights in the moves that call for them.
3. Mindfulness
Concentrate on the muscle you're working to ensure you're taking it through the full range of motion.
4. Posture
Practice "exaggerated perfect posture," says Mincieli. For most moves, this means abs tight, shoulders back, and chest high.
5. Breathing
To help maintain your rhythm, exhale during the positive phase and inhale during the negative. Don't hold your breath -- this can cause your heart rate and blood pressure to spike, leading to lightheadedness and even fainting.


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Recently, Keith Olbermann, on his MSNBC account show, Countdown with Keith Olbermann, cited Fox Account as the "worst bodies in the world." He claimed that the Fox Account Approach is arrant bourgeois propaganda. He aswell acclaimed that President Obama, in a contempo TV account (the aforementioned interview, incidentally, as the now-notorious fly-swatting incident, in which, according to account letters on MSNBC, NBC, CBS, CNN and elsewhere, the President demonstrates his "remarkable fly-swatting skills") claimed that there was at atomic one account approach committed to abrasive his administering at all costs. Olbermann suggests that the President was apropos to Fox News.
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The UKs first ever LGBT History Month magazine is being launched with the support of Angela Eagle
Budget airline EasyJet yesterday offered to fly Pope Benedict XVI to the UK following the recent controversy surrounding his viewpoints on British Equality laws and estimated cost of his visit.
The Sun has caused havoc after publishing a poll yesterday asking whether gay people should be allowed to be cabinet ministers.
The Government will not push through proposals that churches argue would restrict their ability to deny jobs to gay people and transsexuals, Equality Minister Harriet Harman has confirmed.
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'Without doubt, they were the most notorious girl gang Britain's ever seen." (Brian McDonald, The Gangs of London)
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The Background
The Forty Elephants, or the Elephant Girls, are an historic all-female gang which operated in London, England from the mid-1800s to about the 1950s. They were brought to light in 2010 by Brian McDonald who included them in his book The Gangs of London. Maggie Hale is both a conflation of several different historic gang members, and also entirely fictional. Unlike many male gangsters of the period, none of these women ever wrote their memoirs, and today any further information regarding these female "enforcers" is lost to time. Using, then, a combination of meticulous research, instinct, and imagination, this is a story both captivating and repelling, humorous and terrifying.
The Play
The Elephant Girls is written and performed by Margo MacDonald, and directed by Mary Ellis. The show premiered in June of 2015 at the Ottawa Fringe Festival, Canada, where it instantly became a runaway smash hit. In addition to rave reviews, every performance sold out 100% (in fact, it was the first show in the history of the festival to sell-out completely on advance sales alone). The show won all the top Fringe awards, including Best of Fest, Outstanding Production, and Critic's Pick for Best Show. It was then moved into a larger venue and held-over by the Fringe for two additional performances, both of which also sold out. Most recently, it toured abroad to the month-long Edinburgh Festival Fringe. In Canada, the production swept the 2015 professional theatre awards in Ottawa, Les Prix Rideau Awards, winning Outstanding New Work, Outstanding Direction, and Outstanding Performance - Female. Margo also was awarded Best Actress—Professional by the Capital Critics'Circle.
Gritty, humorous, moving and edgy, this play consistently holds audiences captivated. It's the kind of show people line up to see more than once, waiting for hours on the chance of a ticket to the sold-out performances.
This is much more than just a fascinating history; the show raises questions about identity, sexuality, poverty, education, the disenfranchised, the outcast and marginalized, the nature of violence, and more —all of which our society still struggles with today. What is 'belonging'? What's the meaning of 'family'? What price should we be willing to pay for freedom?
This is a story which needs to be told, and one which once heard will not soon be forgotten.
Grab your tickets now : eventbrite-Elephant Girls
****"As soon as the lights come up, Margo MacDonald captivates, knowing how to keep an audience in the palm of her hand…astonishing."
—Ashleigh More, Broadway Baby
**** "…the attention of the audience never strays and remains ensnared in a captivating story.
The play is brilliantly written and exceptionally performed…you will be left wanting to know more. Highly recommended."
—Fringe Guru
"A gripping, psychological insight into gang life… MacDonald is captivating…The Elephant Girls evolves into a deeply psychological struggle between truth and fiction, as Maggie wrestles with the dangerous passion that bubbles beneath her carefully constructed bravado. Complex, subtle, and often deeply uncomfortable, this battle is fascinating to watch."
—Jordan Shaw, The List
Winnipeg Fringe Festival, Winnipeg, MB, Canada—July 2016
***** "A fascinating story, anchored by one of the finest performances you'll find at this year's Fringe. Stampede—do not walk—to The Elephant Girls. … a ferocious, charismatically intense performance."
—Joff Schmidt, CBC Manitoba
***** "MacDonald is captivating as [her character] Maggie slowly strips away her armour, revealing a history of violence, depravation and intensely steamy sexual experience…utterly entrancing…"
—Pat St. Germain, Winnipeg Free Press
Ottawa Fringe Festival & Hold-Overs, Ottawa, ON, Canada—June & July 2015
***** "Gritty, powerful, and excellently crafted... an astounding story... we are fortunate to have seen the world premiere of a show that will undoubtedly become a great success."
–Kat Fournier, Capital Critics'Circle
"This outstanding solo piece wraps issues of power, class and gender in the story of Maggie Hale...Meticulously researched, lovingly scripted, and directed in economical fashion by Mary Ellis... Outstanding. This is the Fringe at its best."
–Patrick Langston, Ottawa Citizen
"I guarantee you will not be disappointed. At times the show is hilarious, others heart breaking, and still others so horrific that you don't want the it to stop because you can't turn away."
—Jeremy Dias, Capital Xtra
"Margo MacDonald is a force to be reckoned with... This was truly a performance that made me forget where I was. For that hour, I was in a pub in London, while a terrifying and fascinating woman told me an unforgettable life story."
—Valerie Cardinal, OnStage Ottawa
"With her sustained working class London accent, her defiant physical stance, her gaze that could destroy innocence and her character's strong presence...[MacDonald] produces a captivating and at times moving performance."
—Alvina Ruprecht, Capital Critics'Circle
"This original show…could possibly become an important text in the Canadian repertoire."
- Capital Critics'Circle
"Superb... a riveting hour."
–John Sekerka, The Revue
© Copyright 2009 Pinkwire, Talent Media.
Designd & powerd by ENTWURF.


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Insurance companies nervous over extent of Oswald damage
INSURERS are bracing for a new round of claims following heavy rains and flooding in Queensland and northern New South Wales at the weekend as ex-tropical cyclone Oswald pounded the coast.
The severe weather is from the first cyclone of the season. More are expected over the next few months and insurers will be on edge until they have a clearer idea of their overall claims exposure.
Several thousand claims have been lodged already, although more are expected as the full extent of the damage becomes apparent.
The bad weather at the weekend comes hard on the heels of the heavy cost of the recent bushfires in Tasmania, NSW and Victoria, with claims from the Tasmanian fires alone costing $42 million so far.
With the Queensland rain and flooding, the insurers with the largest operations in the area, such as Suncorp, IAG and QBE, are expected to face the next round of claims. Suncorp has increased call centre staff to cope with the anticipated high level of calls.
''Claims volumes will come through over the next few days,'' a Suncorp spokeswoman said.
Several homes and commercial properties in and around Bundaberg have been flooded, along with areas of Brisbane such as Redcliffe, Scarborough and Bribie Island. In NSW, properties from Byron Bay to Coffs Harbour were hit by the weather as it moved south.
On Sunday, the Insurance Council of Australia declared parts of Queensland a ''catastrophe'' with moderate to severe damage experienced in communities from the NSW border all the way north to Cairns, with substantial damage reported in the Wide Bay area in particular, the council said.
''The declaration of a catastrophe … means insurers have established a taskforce to help co-ordinate the recovery process,'' the council's chief executive, Rob Whelan said.
Insurers had received several thousand claims by noon on Sunday, he said, although it was too early to estimate insurance losses.
The number of claims will rise in the coming days as property owners returned from holidays. At least 150 properties had reportedly sustained severe damage in the Wide Bay region alone.
''Insurers are greatly concerned about extreme weather expected over the next few days in Queensland, with severe inundation already having been experienced in several towns and cities, and major flood warnings now in place for every river from Cairns to the (NSW) border,'' Mr Whelan said.
''The general insurance industry had anticipated a very wet summer this year, while also hoping Queensland might avoid a repeat of 2011.
''The weather bureau has warned it's highly possible we will see more before the end of summer.''
Since early 2010, the council has declared six catastrophes in Queensland for flooding and cyclone damage, with losses amounting to almost $4 billion.
Apart from the mini-tornadoes that hit some parts of Queensland, there had not been a great deal of wind, so that most claims in Queensland were not expected to be large, typically a broken window that might have resulted in a small rain-affected area, the Suncorp spokeswoman said.
''There has been no major inundation yet, so we anticipate it will be smaller claims,'' she said.


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Married dad overcomes struggle to pursue an Ivy League education
By Dr. Tyra Seldon
In a rap world filled with the likes of Chief Keef, Lil Wayne, Drake and Jeezy, Ill Holiday is not your typical hip hop aficionado. In fact Ill Holiday, better known as Casey Bridgeford, is not your typical anything.
At the age of thirty-one, the married father of four will be a first year student at the University of Pennsylvania in the fall. Having earned a 4.0 GPA at IvyTech Community College in Indianapolis, Indiana, Casey is that rare student who has transcended the ranks of a community college to enter the ivory towers of the Ivy League.
Initially, school was a refuge for Casey. A parent struggled with a drug addiction and he often moved from one housing project to another. Transitioning back and forth from home life to school life eventually took its toll and he found himself disinterested in school. According to Casey, he "couldn't see the connection between school and life." The only time he encountered anyone with the title Dr. was in the emergency room. If it wasn't for members of his church who had college degrees, he wouldn't have known that college was an attainable goal. In his own words, "I didn't have a firm context of what college was."
Like many young men growing up in an urban epicenter, Casey gravitated towards a career as a rap artist. After several years in the music industry and running a successful marketing firm that eventually tanked during the 2008 recession, Casey found himself on the cusp of homelessness with limited income, no job prospects and an eviction notice from his landlord.
In the fall of 2010, he decided to return to school to pursue his education. Undaunted by the prospect of starting over, Casey elected to attend a community college to secure the educational foundation that he needed in order to be successful. Little did he know that after years away from the classroom, not only would he excel, but he mastered the coursework and soon earned 50 credit hours.
This initial success became the springboard for him to dream bigger and broader. Yet, Casey's quest to pursue an Ivy League education and his acceptance is just as unconventional as his avenue to pay for it. Unwilling to saddle his young family with exuberant debt, he has decided to draw on the strength of his community. Like the rent parties that some of us might remember from episodes of Good Times, his friends, family and community members have gotten together to host an educational party and launch an online campaign to help offset the costs of relocating his family to Philadelphia.
As easy as it is to surmise that Casey's educational success story is one that others' cannot obtain, he would caution otherwise. "Young people have to look at the long term effects of their decisions. If they do so, it will become clearer what they need to do and how they need to do it. It is when we focus on short term goals that we make short term decisions. My greatest transition wasn't shifting from a community college to the Ivy League; it was transitioning my thought process."
Dr. Tyra Seldon is an independent scholar and freelance writer who is committed to eradicating educational disparities. This article is a part of Your Black World's Education over Incarceration Project.


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I'm an architectural photographer, living in Rome, Italy. Involved in traditional and large format photography in territorial documentation, in 1998 I discover the perfect way to represent and display very large views: the immersive photography.
Beside "normal" immersive photography, like landmarks panoramas, I make researches on the potentials of this new media, working with artists and applying it to particular subjects.


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A person let out of a vehicle with only parking lights, walks with their small flashlight toward the entrance tunnel of the Residencia at the observatory under a carpet of stars formed by the Milky Way. The glass dome on the roof of the Residencia is barely visible in the lower right, reflecting stars in the sky.
Large Magellanic Cloud
Flight to Venus
TO BUY PRINTS OF THIS PHOTO CLICK ON http://www.rqfphoto.com/Events/Flight-to-Venus/23612068_mGJB8r
This is a United Parcel Service MD-11 aircraft UPS Flight 4911 en route from Ontario, CA to Louisville, KY flying at 37,000 ft and was 71.3 miles from the camera. Elevation was 3.5 degrees.
After a week of inquiries, I have made contact with the crew -- Captain David Kantor and 1st Officer Dean Burke. I have made two large prints and will be mounting, framing, and sending them to David and Dean.
See next photos for a map showing the locations of the camera and aircraft and presentation of the prints to the crew members.
All photographs Copyright 2017 by Bob Fugate. No use without Authorization. Contact email@example.com
ABQ to PHX to MRY and returnPhoenixalbuquerquedesertmontereywindow seat


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New Raiders coach Dennis Allen dipped into a familiar location to find a replacement for departed defensive line coach Mike Waufle. Allen on Monday hired Texas A&M defensive line coach Terrell Williams to succeed Waufle, according to Rivals.com.
Williams 37, spent the past two seasons as the Aggies defensive line coach. Coincidentally, Allen played for Texas A&M and got his coaching start with the college.
The Aggies ranked 12th nationally against the run last season, at an average of 101.9 yards per game. Stopping the run has been a huge priority of past Raiders coaches, with little success.
Texas A&M ranked 90th against the run before Williams' arrival. They improved to 30th in 2010 and jumped to 12th last year.
Last season, the Raiders allowed 5.1 yards per carry and finished near the bottom of the league in average yards per game.
Williams also coached the defensive line at Purdue, Akron and Youngstown State before he joined the Aggies staff.
One of Williams' prized pupils was defensive end Cliff Avril, who played for the Detroit Lions last season and is a prospective free agent.
The Raiders have not confirmed Williams' hire. Same goes for the reported hires of Ted Gilmore, Johnny Lynn and Mark Hutson.
Follow me on Twitter: @corkonthenfl


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[Frances Woodward Ferguson]
Description: An Entry in Weslaco's annual "Birthday Party" fashion show. Organized by the Chamber of Commerce to highlight the fruit and vegetables grown in the Rio Grande Valley, area citizens created and modeled clothing made from local fruit, vegetables, and flowers. Frances is wearing a gown with bustle effect composed of grapefruit seed. The nosegay was made of membrane giving the effect of orange blossoms. Costume weighed 60 lbs. Representing the Rio Grande Valley Citrus Exchange Employees.
Date: December 8, 1939
Item Type: Refine your search to only Photograph
Partner: Weslaco Museum


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Tile Panel Systems
Tyvarian Photo Galleries
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Tyvarian technology has homeowners and designers recognizing its value in a multitude of applications along with bathrooms & kitchens. This innovative and unique process incorporates high definition images with our Cultured Marble. Creating the look of Natural Stone, Granite, Travertine & Onyx (in both honed & polished finishes). Our stylish new product is a durable, colorful and maintenance free surface with endless design capabilities limited only by your imagination.


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Current Selections
Our Sherwood bedroom storage collection offers beautiful Arts and Crafts design at an outstanding value. Built by North Dakota woodworkers, each modern kids' dresser and storage cabinet features solid wood and high-quality wood veneers sealed with a natural oil-and-wax finish.See the full Sherwood collection
Details of Sherwood 49w 19d 35h Seven-Drawer Dresser
Product Details
- Dimensions: 49"w 19"d 35"h
- Width: 49"w
- Floor to Bottom Clearance: 5.5"h
- Space Between Legs: 46"w 14.5"d
- Leg Thickness: 1.5"w
- Case Construction: benchmade solid wood and wood veneer with unfinished wood veneer back
- Drawer Construction: solid wood front; Baltic birch plywood sides; dovetail joinery; wood veneer bottom
- Drawer Details: full-extension ball-bearing glides; 100-lb capacity
- Drawer Interior: (2) 8.25"w 15"d 4.25"h; (1) 18.25"w 15"d 4.25"h; (4) 18.25"w 15"d 6"h
- Includes: 4 oz bottle of Satin Wax; anti-tip safety hardware
- Certification: meets voluntary ASTM F2057-14 anti-tip safety standard for clothing storage units over 30" high
- Product Origin: made in North Dakota
- Material Origin: United States and imported
- Item Number: 004860
- See all photos
Material Details
- Wood: maple
- Finish: oil-and-wax
- Material Description: Maple adds timeless warmth and lightness to your room. Even after maple is harvested and made into furniture, it continues to be a living, breathing material that responds to its environment - it expands and contracts with changes in humidity and also changes color over time as it's exposed to air, sunlight and wear. New maple ranges in color from cream to gold and will beautifully deepen in gold tones over time.
- Wood: maple
- Finish: oil-and-wax
- Hardware: stainless steel
- Material Description: Our stainless steel has an upgraded metal composition to better resist corrosion and wear and tear. A brushed texture ensures wear marks will blend in over time and when cared for properly, stainless steel will last a lifetime.
- Hardware: stainless steel
- Colors may vary depending on your monitor and printer. For color accuracy, request a swatch.
Receive unlimited items for only $99 within 100 miles of our stores or $139 anywhere else in the contiguous United States. Plus enjoy free UPS shipping on hundreds of select items. Learn more: www.roomandboard.com/delivery
More items in the Sherwood Collection
Our promise to you
Exceptional Service, Start to Finish
We treat you the way we would like to be treated, from shopping and ordering to delivery and long-term service.
American craftsmanship
More than 90% of our products are manufactured in America using quality U.S. and imported materials. Working with family-owned companies around the country allows us to bring you the best craftsmanship and fastest delivery with the least environmental impact. It also means you get furniture with a story you'll be proud to share.
Free design services
Our Design Associates put their product expertise and passion for home design into helping you create a functional and inspiring space. Their design help is always available to you for free.
The best price every day
We work directly with our manufacturing partners to bring you the best quality at the lowest possible price, every day. Our prices are guaranteed for the calendar year so there's no need to rush—or any reason to wait—to buy what you love.
Unlimited Items for One Flat Rate
Receive unlimited items for $99 within 100 miles of our stores or $139 anywhere else in the contiguous United States. Small home decor items ship for free via UPS.
Full-Service Delivery
Our respectful Delivery Associates take care of every detail. Furniture arrives fully assembled and is placed exactly where you want it with no packaging left behind.
Free Returns and Exchanges
We offer free return or exchange delivery service on any item you buy from us. We understand that it can take a few days to a few weeks to determine if your new furniture will work for you. We encourage you to make a return or exchange in a timely manner because damaged, worn or altered items may be refused or result in an adjustment to your refund.
Our Guarantee
We stand behind the quality of our products and the prices we charge. If you're not satisfied with your purchase or any part of your experience, just let us know. We're here to help.


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Story highlights
- France Football magazine declares Lionel Messi the world's highest-earning player
- It says Argentina striker earned $52 million in wages and sponsorships in 2011
- Second on the list is former England captain David Beckham after taking home $50 million
- Real Madrid's Cristiano Ronaldo is third on the list after collecting $46 million
Lionel Messi is widely regarded as the world's best footballer -- and now it seems the Argentina star is also unrivaled among his peers off the field.
David Beckham has long been the sport's biggest earner even in his declining years, due to his lucrative endorsement deals, but the former Manchester United and Real Madrid superstar has been eclipsed by Barcelona's magician.
The three-time World Player of the Year was unveiled by France Football magazine as the highest-earning player in soccer on Tuesday, collecting €33 million ($52 million) in wages and endorsements during 2011.
The 24-year-old, who has scored 51 goals for the Catalan giants in all competitions, headed a list which placed Los Angeles Galaxy's former England captain Beckham in second on $50 million.
Beckham recently signed a new contract with the Galaxy, and unveiled a clothing line with Swedish retailer H & M earlier this year.
Messi's on-field rival Cristiano Ronaldo also featured highly. The Portugal forward's total earnings of $46 million in 2011 put him third ahead of Samuel Eto'o of Cameroon.
Eto'o secured a lucrative move from Inter Milan to big-spending Russian team Anzhi Makhachkala in August 2011 and he has reportedly banked $37 million.
Manchester United and England striker Wayne Rooney was fifth on the list with $32.6 million, while the Manchester City duo of Argentina's Sergio Aguero and Yaya Toure of the Ivory Coast took home $29.7 million and $27.8 million respectively.
Completing the top 10 were Chelsea striker Fernando Torres ($26.4 million), Real playmaker Kaka ($24.5 million) and Bayern Munich's Germany captain Philipp Lahm ($22.6 million).
France Football is one of Europe's leading sports magazines, and it formerly organized the Ballon d'Or awards for the continent's top achievers.
The Ballon d'Or has now merged with ruling body FIFA's world player of the year awards.