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text: A lobby and a reception are available to guests. Services such as a safe and currency exchange facilities make for a comfortable stay. Internet access and wireless internet access (no extra charge) are available in the public areas. Gastronomic options include a restaurant and a bar. Guests can visit the supermarket to purchase daily necessities. A garden is among the features contributing to a pleasant stay.

subset: commoncrawl


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KUCHING: Personnel from enforcement agencies led by Land and Survey Department demolished the premises and facilities built illegally on government land at the entrance to Santubong National Park yesterday.
In another operation the team also demolished 24 structures and buildings built without approval on state land and land belonging to Federal Land Commissioner at Semariang Tanah Merah area.
The Land and Survey Department, in a press statement yesterday, said the two operations, Ops Santubong and Ops Tanah Merah were carried out after the owners failed to comply with the eviction order issued by the department.
The department said "Ops Santubong' was conducted to solve the issue of the leisure activities operator who had illegally collected entrance fee to Santubong National Park area after the company's agreement with the authorities was terminated."
The entrance fees were collected without approval from the Controller of National Parks and Nature Reserves which meant the operator had committed wrongful obstruction by not allowing visitors to enter the national park area if they did not pay the entrance fee.
"Besides that the premises the company operated at two main entrances to Santubong National Park were built on government's land without approval from the Land and Survey Department," the statement added.
Meanwhile, a shocked Dayang Noorazrina Abdullah, who operates mountain climbing and jungle trekking business at the entrance to Santubong National Park, insisted that she was licensed to conduct business at the entrance and maintain the jungle trek at the national park.
She said that her daughter, Dayang Noorazilla Jasni was also licensed to operate the restaurant at the entrance to Santubong National Park, adding their licence to operate jungle trekking and mountain climbing business would only expire in two years time, while the licence to operate restaurant expires next year.
Dayang Noorazrina claimed she charged the RM8 entrance fee after the authorities agreed with the terms stated when obtaining the letter of support from them.
Dayang Noorazrina said the minimal amount charged was used to hire people to maintain the cleanliness in the national park as her company was requested by the authorities to maintain the cleanliness of the national park.
While acknowledging that she received a letter on Oct 29 this year, giving her seven-day notice to vacate the premises, she claimed that she had replied the letter the next day but there was no reply from the authorities.
Dayang Noorazrina also refuted claims that she had encroached into state land as she claimed that a cable car project operator had acquired the area and agreed to grant her a small plot of land which had been surveyed for her to run her business.
"I am aware that many parties are not happy with us operating our business here because they want to take over the jungle trekking business here. I believe there is a conspiracy behind the demolition of our premises to kick us out from here and stop us from operating our business."


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Mathew Knowles' latest baby mama, TaQoya Branscomb is offended that anyone would label her as an opportunist.
Once a lingerie model and now a real estate agent, people have accused TaQoya of looking for a comeup when she hooked up with Mathew. It's not that people hadn't been saying it since news of his youngest daughter Koi popped up, but its only gotten worse since TaQoya reveled the adorable little brown girl.
In a statement released to TMZ by a family court in Houston, TaQoya insists that she would have announced her baby with Mathew well before now if she was simply looking to capitalize on his name.
"Mathew and I had a romantic relationship in 2009 during a difficult time in his life. It had nothing to do with Beyoncé's music career. Despite the media speculations, I am not an 'opportunist,' if that was the case I would've spoken out four years ago. I was just as shocked as anyone when the information was leaked."
She added, "I had remained quiet and raised my daughter as a single mother in a happy and healthy environment."
Ideally, TaQoya said she would rather that her paternity battle with Mathew hadn't been splashed across the Internet and tabloids, but she doesn't think she had any other choice.


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Dr. Norman Kretchmer, a leading expert on infant nutrition, died last Wednesday in the Moffett Hospital of the University of California at San Francisco. He was 72 and lived in San Francisco.
The cause was kidney failure due to myeloid metaplasia, a bone-marrow disease, his family said.
Dr. Kretchmer was professor emeritus of nutrition at the University of California at Berkeley and professor emeritus of obstetrics and pediatrics at the San Francisco campus. At his death he was editor in chief of The American Journal of Clinical Nutrition, a monthly published in Berkeley by the American Society of Clinical Nutrition.
He received national attention in 1972 when he reported that experiments at Rockefeller University had shown that human infants and rats evidenced certain basic tendencies related to nutrition. At the time he was a professor of pediatrics at Stanford University. For instance, he established that the way a mother feeds her infant during the first year of his life may be crucial in determining how healthy he will be as a grown-up.
He established that fat infants tend to have obesity problems as adults but thin babies do not. Also, babies who are fed large amounts of sugar may have a tendency to develop heart trouble as adults more readily than those with fewer sweets in their diet. And he found that the nutritional needs of infants differ from those of adults. For instance, many infants cannot readily make an amino acid that is a building block for protein synthesis. Adults can synthesize it, but infants must obtain it from mother's milk.
Norman Kretchmer was born in Manhattan and graduated from Cornell University in 1944. He received a master of science degree the following year from the University of Minnesota, where he also earned a Ph.D. in physiological chemistry in 1947. He worked and taught in that field before he got his M.D. at the State University of New York in 1952.
He was associated with Cornell and Stanford until he was appointed director of the National Institute of Child Health and Human Development, a branch of the National Institutes of Health, in 1974. He held that post until 1981, when he joined the faculty of the University of California at Berkeley and San Francisco.
He wrote "Developmental Nutrition" (Franklin, 1994) and "Sugar and Sweetness" (CRC Press, 1991). He also contributed to "Prenatal and Perinatal Biology and Medicine" (Gordon & Breach, 1987). All remain in print.Continue reading the main story
Dr. Kretchmer is survived by his wife, Midge Reiter Kretchmer; a daughter, Pamela Senuty of Los Angeles; two sons, Paul, of Mill Valley, Calif., and Steven, of Los Angeles; a sister, Francine Garcia Braunstein of Manhattan, and five grandchildren.Continue reading the main story


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How to make snap poppers - Amazon.com snap poppers
how to make masala soda powder
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Tania Patterson
Moving parts give Tania Patterson's jewellery a distinctive personality. Wearing her jewellery is an activity rather than a passive display, as many of her works have a kinetic aspect which directly involves both viewer and wearer. Her current concerns include bracelets and necklaces which focus on wearability and relate directly to the body. Tania's new necklaces, in the form of single seedpods hanging from a simple wire strand, have softer lines and retain the kinetic aspect.


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Jim Irwin (Civilian)
Gender: Female
Hometown: Illinois
Military Status: Veteran
About Me:
married, 2 children, 3 grandchildren
self-employed contractor
married, 2 children, 3 grandchildren
self-employed contractor
Jim's Assignment History
MCB Camp Lejeune
Unit: force service regiment
MCAS Iwakuni
Unit: MAG II
MCB Camp Pendleton
Unit: FSR
Jim's Salutes
1 - 1 out of 1
Tamie Towers said on 02/24/2012 at 03:47 pm
I'll Go (A Soldiers Oath) - I would like to share with you, a music video dedicated to all soldiers called - I'll Go (A Soldiers Oath) - by Kelly's Lot - It is a tribute to all veterans, and is well worth watching - Here's the link: (this is not a download, simply a link to a YouTube video) - http://youtu.be/c5p1Qiqggao - Or you can copy & paste (or type) the following link into your address bar: http://youtu.be/c5p1Qiqggao - To each and every veteran - Thank You - I salute you - Tamie L. Towers - Patriot - email@example.com - P.S. My dear friend Kelly Zirbes of Kelly's Lot wrote and performed this song and has given permission for the video to be shared and/or embedded anywhere.
Connect with Jim
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A turning point in Korean history, one never to be forgotten is presented in this engaging historical drama, celebrating its 100th anniversary. In 1919, during the Japanese colonial period, two events paved the way for the independence of Korea, the March 1st Movement and the establishment of the Provisional Government of the Republic of Korea. And with it, a covert armament for freedom was born, the Heroic Corps. Historically and in the drama, the man leading the corps goes by the name of Kim Won Bong, his real name only a few people know. He rarely stays in one area for more than two hours and sleeps for only short periods at a time. With fiery passion in his heart, he moves about swiftly and dreams for his country's independence. Lee Young Jin a Korean woman raised by a Japanese military doctor follows in her surrogate father's footsteps, and through a series of events, attends a prestigious medical university in Shanghai. She returns to Joseon and becomes the first female surgeon. The two them cross paths, and although they follow different ideologies, Won Bong soon realizes his need for her and begins to regret sending her deep into enemy territory. These two characters will walk together, sometimes run, sometimes fall, only to get back up again to chase their dreams. Bearing with them the pain and suffering of the historical events that shaped Korea's independence, they hope to instill the past so that it will never be forgotten.
- Original title
- 이몽
- Volunteer Team
- Different Dreams Volunteer Team
- Broadcast Network
- Broadcast Period
- 05-04-2019 to 07-13-2019
- Rating
"Different Dreams" Broadcast Cut In Half This Weekend
Yoo Ji Tae And Lee Yo Won Get Closer After Their Trip In "Different Dreams"
"Her Private Life," Kim Jae Wook, And Park Min Young Top Rankings For Most Buzzworthy Dramas And Cast Members
"Voice 3" Premieres To Higher Ratings Than Season 2 Finale
QUIZ: Plan Your Dream Vacation And We'll Tell You What K-Drama You Should Watch Next


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Austin Bryant
Posted on January 5, 2012
AUSTIN BRYANt is a Boston-based percussionist, performer, and educator with over 15 years of teaching and playing experience. Currently, he teaches at Zach Field Drum Studios located in Newburyport, MA.
He attended The University of Massachusetts, Lowell earning a Bachelors Degree in the study of Music Performance with an emphasis in Music Business. While attending school, he studied jazz, funk, and classical percussion with such performers as Fred Buda (Boston Pops), Jeffrey Fischer (Boston Ballet), Jim Lattini, Dave DiCens0 (Berklee College of Music) ,Bob Gullotti (Berklee College of Music), James Murphy (Berklee College of Music) and most recently Mike Johnston.
His recordings with various artists have been featured on MTV, ETV!, ABC Family, and VH1. He has written songs for Disney/ ABC Family and the corporation Insulet/ Omnipod as well. Austin has performed with an array of groups and artists including Contact, whose single "Never Stop" has reached over 1 million plays on Spotify and was on the Top 5 Global and National Viral playlists, Dan Masterson, James Montgomery and Friends, Beneath The Sheets (featured at Warp Tour 2013), 7 Mile Drive, Sophie B. Hawkins, Jeff Gordon, The Rebels of Art, The Catch Trio, The Vesps, The University Wind Ensemble, directed by David Martins, The University Concert Band, directed by Daniel P. Lutz, Percussion Ensemble, directed by Jeffrey Fischer, and The University Big Band and Jazz ensembles, directed by Walter Platt.


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How to use microsoft link 2010
This Quick Start outlines basic tasks for communicating by using Microsoft® Lync ™ communications software. It explains how to use Lync to easily. Upgrade from Lync to Microsoft Teams in Office Still using Lync? Put conversation at the center of work with Microsoft Teams in Office Lync Quick Start Guides. Important! Selecting a language below will dynamically change the complete page content to that language.
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David di Donatello Awards
2012 David di Donatello awards and D.A.S. Audio
2012 David di Donatello awards and D.A.S. Audio
Rome, the capital of cinema. The David di Donatello Awards, presented annually for cinematic production and performances. Italy's Eternal City recently played host to these coveted film awards, which recognize actors, producers, directors, and film professionals in 24 different categories. The Taviani brothers led the night and took home awards including Best Picture, Producer and Director for their film "Caesar Must Die", which also received a Golden Bear at this year's Berlin International Film Festival.
Not only are the David de Donatello Awards a prestigious night for the film industry: the ceremony is a glamorous must-attend event for celebrities as well. Several national and international stars - including singer Cesare Cremonini, director and screenwriter Paolo Sorrentio, and actress Zhao Tao - walked the red carpet at this year's awards, at the Auditorium Conciliazione in Rome.
Sound professionals AUDIOVISIONI s.r.l. handled the entire audio installation for the award ceremony. AUDIOVISIONI had already worked with the new D.A.S. Audio systems at their installation for the major Italian theater production of the La Cage aux Folles and Il Vizietto musical, written by Max Romeo Piparo, with a cast led by Massimo Ghini and Cesare Bocci. For the David di Donatello Awards at the Auditorium the AUDIOVISIONI team opted for a range of D.A.S. Line Array systems for sound reinforcement, specifically:
16 Aero 12A powered two-way line array speakers


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Exactly Exactly Just How Crucial Is Psychological Connection in a Relationship?
Love isn't only a concept that is abstract of literary works, love is a deep dependence on accessory. It's very important for an individual to learn that these are generally of good value to some body. The look for and upkeep of experience of significant other people is an natural and primary inspiring element in individuals. In the event that anyone to that you're connected becomes emotionally inaccessible, you could begin experiencing anxiety, fear, consternation, and alienation. All of this, in change, causes dangerous cycles of relationship that destroy relationships. The psychological disconnection of lovers is significantly more harmful than their incapacity to negotiate within a conflict. In reality, every few gets through quarrels, but while lovers have actually a psychological connection, absolutely absolutely absolutely nothing severe can happen for their relationships.
Feelings, some joint experiences since well as a way to share their secrets brings individuals closer helping them feel one another on a level that is new aswell as understand more deeply. To possess a healthier and strong relationship , you will need to produce a » cost cost cost savings package" of provided moments. All of this needs to be done at a phase if the attraction that is natural persists, and both lovers have actually a link at the physiological level.
What exactly is a psychological connection?
In accordance with accessory theory, a psychological connection is among the typesof a relationship. The essential example that is common function as the psychological connection that exists from a parent and a kid. Other examples will be the connections between intimate partners, buddies, and family unit members.
A stronger connection that is emotional created whenever mother responds into the requirements of her kid. This connection is incorporated because of the kid's character and functions as the foundation for several their future relationships. You can find five primary requirements of psychological connection.
- Psychological connection is permanent, maybe maybe maybe not short-term.
- Psychological connection is concentrated on a particular individual.
- Relationships, that are suggested by psychological connection, are of good importance for the sphere that is emotional of individual.
- Someone seeks to keep in touch with an individual with who they will have a psychological connection.
- Forced parting with a partner results in bad mood and total unhappiness.
By psychological connection, individuals suggest the establishment of a internal Attachment based on respect and understanding when it comes to individual, their interests, requires, and dilemmas. If such an association isn't founded, then your relationship is not called full-fledged.
Let's say there's absolutely no connection that is emotional?
If you have a lack of psychological, then such ties derive from consumerism. Usually, these are typically covered byself-deception, leaving the belief that everything is the real means it offers become. Many individuals create entire theories to justify the customer mindset toward other people and also reproduce them. …view the rest


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Opinion ARTICLE
ATP-induced P2X Receptor-Dependent Large Pore Formation: How Much Do We Know?
- 1Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, China
- 2Faculty of Biological Sciences, School of Biomedical Sciences, University of Leeds, Leeds, UK
P2X receptors are a group of homo/hetero-trimeric membrane protein complexes with an integral ion channel that opens upon extracellular adenosine triphosphate (ATP) binding (North, 2002; Khakh and North, 2006). There are seven P2X subunits (P2X1-P2X7), all having a membrane topology of cytosolic N- and C-termini, and two transmembrane segments (TM1 and TM2) connected by a large extracellular domain (Figure 1A; Jiang L.-H. et al., 2013). During application of ATP for a few seconds, P2X receptors function as classical ligand-gated ion channels selectively permeable to small physiological cations such as Ca2+, Na+, and K+, with the exception of the human P2X5 receptor which exhibits significant Cl− permeability (Bo et al., 2003). Site-directed mutagenesis and functional studies of mammalian P2X receptors, in addition to the determination of the crystal structures of zebrafish P2X4 receptors in the apo, closed state and ATP-bound, open state, have defined the structural basis for ATP binding, ion permeation and channel gating (Kawate et al., 2009; Browne et al., 2010; Hattori and Gouaux, 2012; Jiang L.-H. et al., 2013; Jiang R. et al., 2013). Three ATP-binding pockets are located at the subunit interfaces (Figure 1B), each consisting of highly conserved residues from two adjacent subunits. Occupation of these sites by ATP or its synthetic analog agonists induces conformational changes of the extracellular domain which open the ion-permeating pathway formed by three TM2s (Figures 1C,D). The narrowest part of the ion-permeating pathway or the physical gate is provided by A347 and L351 in the crystal structures of zebrafish P2X4 receptor (Hattori and Gouaux, 2012) or the corresponding residues S342 and L346 in the structural models of rat and human P2X7 receptors (Figure 1D) (Bradley et al., 2011; Browne et al., 2013; Jiang L.-H. et al., 2013).
Figure 1. Structural models of the human P2X7 ion channel in the closed and open state. (A,B) The structural models of the trimeric human P2X7 receptor in the closed (A) and open states (B), viewed parallel to the plasma membrane. They are generated based on the crystal structures of zebrafish P2X4 receptor (4DW0 and 4DW1 respectively). Each subunit is shown in a different color. Three ATP molecules shown in space filling representation bind to the three inter-subunit interfaces (B). (C,D) The transmembrane ion-permeating pathway in the structural models of the human P2X7 receptor in the closed (C) and open states (D), viewed from the intracellular side of the membrane. The three TM1 helices are located at the periphery and the three TM2 helices in the center form the ion-conducting pathway. Ser342 and Leu346 from each of the three subunits provide the narrow part of the ion-conducting pathway in the open state (D).
It is well known that extended application of ATP to activate the P2X receptors for tens of seconds or minutes induces a remarkable increase in membrane permeability to large molecules of up to 900 Daltons, a phenotype often referred to as formation of large pores. This was originally documented in immune cells about three decades ago; ATP permeablized cell membranes to nucleotides (Cockcroft and Gomperts, 1979) and the cationic fluorescent dye ethidium in mast cells (Gomperts, 1983), or the anionic organic dyes lucifer yellow and carboxyfluoresceine in mast cells and macrophages (Bennett et al., 1981; Steinberg and Silverstein, 1987). These immune cells express the formerly named P2Z receptor, which is now known as P2X7 receptor, and heterologous expression of P2X7 receptors conferred ATP-induced large pore formation (Surprenant et al., 1996). Such large pore formation has also been observed during sustained activation of other P2X receptors including P2X2, P2X2/3, P2X2/5, and P2X4 receptors (Khakh et al., 1999; Virginio et al., 1999a,b; Compan et al., 2012). Substantial efforts have been devoted to understanding P2X receptor-dependent large pore formation, but it has been difficult to interpret in a unified mechanism all results from studies examining different receptors in different cell types with different receptor expression levels. Two distinctive mechanisms or hypotheses have been proposed (North, 2002; Pelegrín, 2011; Jiang L.-H. et al., 2013). The first is that persistent activation of P2X receptors induces dilation of the small ion-permeating pathway. The second, alternative mechanism is that a separate membrane protein interacts with the P2X receptor and forms the large pores upon activation of P2X receptors. For example, pannexin-1 was shown to form large pores associated with activation of the P2X7 receptor (Pelegrin and Surprenant, 2006).
Two experimental approaches are commonly used to study P2X receptor-dependent large pore formation. The biophysical approach is to patch-clamp record agonist-induced currents with Na+ and N-methyl-D-glucamine (NMDG+) being the cation in intracellular and extracellular solutions, respectively (Surprenant et al., 1996; Khakh et al., 1999; Virginio et al., 1999a,b). Under such bi-ionic conditions, if the cell membrane is held at a negative potential, activation of P2X receptors induces initially outward currents which decline in amplitude as the receptor activation continues. Within tens of seconds these outwards currents change into inward currents. The current reversal potential exhibits a progressive shift toward the less negative direction (example recordings see Surprenant et al., 1996; Khakh et al., 1999; Virginio et al., 1999a,b; Bo et al., 2003; Jiang et al., 2005). If one assumes the intracellular and extracellular cation concentrations remain unchanged during patch-clamp recording, the shift in the current reversal potential can be interpreted as a result of an increase in the NMDG+ permeability of the cell membrane, namely, the open ion channel is poorly permeable to NMDG+ at the beginning of receptor activation but significantly increase its NMDG+ permeability as the receptor activation continues. Such an interpretation has led to the pore dilation hypothesis (Virginio et al., 1999a; North, 2002). In addition to the P2X receptors, this biophysical approach has been used to show increases in the permeability during activation of other ion channels such as TRPV1 (Chung et al., 2008; Samways et al., 2008; Munns et al., 2015) and TRPA1 (Chen et al., 2009). The second method to study large pore formation is to use fluorescence microscopy or a fluorescence detection system to monitor agonist-induced intracellular accumulation of fluorescence dyes such as YO-PRO-1 and ethidium, or alternatively agonist-induced progressive loss of preloaded fluorescence dyes such as calcein (example recordings see Surprenant et al., 1996; Virginio et al., 1999a,b; Jiang et al., 2005; Sorge et al., 2012). Measurements of dye uptake (or loss) are often made in more physiological solutions containing micromolar concentrations of fluorescent dye and, by and large, avoid the complications associated with complete removal of extracellular physiological cations. One well-documented example of such complications is that the P2X7 and P2X2/5 ion channels activated in extracellular NMDG+-containing solutions were somehow trapped in an open state and did not return to the closed state even minutes after agonist application was discontinued (Jiang et al., 2005; Yan et al., 2008; Compan et al., 2012). Therefore, the findings from measurements of fluorescence dye uptake are of much more biological relevance. The amplitude and rate of fluorescence dye uptake are grossly indicative of large pore formation (e.g., Roger et al., 2010; Browne et al., 2013).
It was assumed in previous studies, despite not always being stated explicitly, that P2X receptor-dependent large pores serve as the common pathway permeating NMDG+ and fluorescent dye uptake. However, this was challenged in a previous study examining the rat P2X7 receptor heterologously expressed in human embryonic kidney (HEK) 293 cells (Jiang et al., 2005). The study showed that sustained activation of P2X7 receptor in extracellular Na+-containing solutions induced robust YO-PRO-1 dye uptake but, surprisingly, no increase in the PNMDG/PNa. In addition, the study found that removal of a cysteine-rich microdomain in the proximal part of the intracellular C-terminus almost completely abolished agonist-induced reversal potential shift under bi-ionic conditions without compromising agonist-induced YO-PRO-1 uptake. In fact, as compared to the wild-type receptor, expression of the deletion mutant receptor resulted in higher YO-PRO-1 uptake in both Na+-containing and NMDG+-containing solutions (Jiang et al., 2005). These two independent lines of evidence strongly argue against the idea that a same molecular mechanism is used to mediate the entry of both NMDG+ and YO-PRO-1 into the cell. In HEK293 cells heterologously expressing the rat P2X2 receptor, a recent study has found that ATP activation of the P2X2 receptor in extracellular Na+-containing solutions induced no increase in the PNMDG/PNa (Li et al., 2015). The study has elegantly introduced a reservoir model to support the notion that the reversal potential shift simply arises from substantial reduction in the intracellular Na+ concentration and increase in the intracellular NMDG+ concentration during prolonged P2X2 ion channel opening. In their model, the P2X2 ion channel is NMDG+-permeable, albeit with the PNMDG/PNa of 0.05, but there is no need for an increase in the NMDG+ permeability, in other words, no pore dilation! The study has demonstrated that the open P2X2 ion channel permeates NMDG+ as quickly as small cations like Na+, but not as easily as the latter ions. The P2X7 open ion channels also exhibit extremely low, if any, NMDG+ permeability (PNMDG/PNa ~ 0.03-0.04; Virginio et al., 1999a; Jiang et al., 2005). Structural modeling based on the open state structure of zebrafish P2X4 receptor (Hattori and Gouaux, 2012) positions the Cα atoms of three S342 residues in the physical gate of the ion-permeating pathway as being 6.4 Å from the central axis in both rat and human P2X7 receptors (Browne et al., 2013; Jiang L.-H. et al., 2013; Figure 1D). NMDG+ has a size of 6 Å × 6 Å × 12.5Å and therefore, as proposed in a recent study (Browne et al., 2013), the P2X7 open ion channels may be sufficiently wide to permeate NMDG+.
The commonly used fluorescent dyes are, however, considerably larger in size than NMDG+, for example YO-PRO-1 (7 Å × 8 Å × 19Å) and ethidium (6.5 Å × 11 Å × 13Å) (Browne et al., 2013). How do the fluorescent dyes come across the cell membrane, also through the ion-permeating pathway? Previous studies showed YO-PRO-1 uptake following activation of P2X2, P2X2/3, and P2X4 receptors (Khakh et al., 1999; Virginio et al., 1999b). The open ion channels of these receptors, if permitting passage of YO-PRO-1, have to open much more widely than the above-mentioned ion-permeating pathway revealed in the open state structure of zebrafish P2X4 receptor (Hattori and Gouaux, 2012). Such a possibility remains to be tested. A recent study has investigated whether the rat P2X7 ion channel was able to permeate large molecules, including the cationic fluorescent dyes YO-PRO-1 and ethidium, the anionic fluorescent dye fluorescein isothiocyanate (FITC; 8.5 Å × 11 Å × 14.5Å), and neutral cysteine-modifying 2-aminoethyl methanethiosulfonate (MTSEA; 5 Å × 5 Å × 10Å), MTSEA-biotin (7.5 Å × 8 Å × 18.5Å) and MTS-rhodamine (9 Å × 14 Å × 16.5 Å) (Browne et al., 2013). ATP-induced ionic currents and YO-PRO-1 uptake both strongly depend on membrane potential, the driving force for movement of charged molecules. ATP also induced uptake of ethidium and FITC in a correlating fashion even though these two dyes bear opposite charges. ATP-induced ethidium uptake was reduced and by contrast ATP-induced FITC uptake was increased by membrane depolarization. Furthermore, introduction of a positive charge by T348K mutation or neutralization of a negative charge by D352N in the small ion-permeating pathway resulted in a decrease in ATP-induced ethidium uptake but an increase in ATP-induced FITC uptake. Finally, MTSEA-biotin and MTS-rhodamine as well as MTSEA readily modified cysteine replacing G345, a position internal to the narrowest part of the P2X7 open ion channel, and inhibited ATP-induced ionic currents and ethidium uptake. These results provide direct evidence to demonstrate that the rat P2X7 open ion channel can permeate large molecules. However, to accomplish this, the open ion channels need to be a minimum of 14 Å wide. This is noticeably wider than the ion-permeating pathway in the open state models of rat and human P2X7 receptors, supporting the notion that the open ion channel dilates (Virginio et al., 1999a; Browne et al., 2013). Structural determination of the ion-permeating pathway of a mammalian P2X receptor in the open state will provide the key answer to whether or how the open ion channel allows passage of fluorescent dyes.
In parallel with these efforts to understand P2X receptor-dependent large pore formation, studies have accumulated evidence to show the importance of such receptor functionality. For example, P2X7 receptor-dependent large pore formation has been identified as a crucial factor associated with disease conditions such as chronic pain (Sorge et al., 2012), osteoporosis (Syberg et al., 2012) and geographic atrophy (Fowler et al., 2014). Furthermore, preferential inhibition of P2X7 receptor-dependent large pore formation has been proposed in a recent study to be the molecular mechanism underpinning the anti-inflammatory activity of nucleoside reverse transcriptase inhibitors, a class of clinically proven drugs treating HIV (Fowler et al., 2014). Selective targeting of P2X7 receptor-dependent large pore formation appears a promising and novel pharmacological intervention (Jiang, 2015). Therefore, it becomes increasingly interesting and important to gain a better mechanistic insight into large pore formation after activation of P2X receptors, in particular P2X7 receptors.
Author Contributions
LW, L-HJ and DL led the discussion; EC contributed to the discussion and generated the structural models. L-HJ wrote the manuscript, and all authors commented the manuscript.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The research from the authors' labs described in this article has been supported in part by grants from Biotechnological and Biological Science Research Council (BB/C517317/1), Natural Science Foundation of China (81371346), Department of Education Henan Province, and start-up fund from Xinxiang Medical University. EC is a recipient of Wellcome Trust PhD studentship.
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Keywords: ATP, P2X receptor, large pore formation, ion-permeating pathway
Citation: Wei L, Caseley E, Li D and Jiang L-H (2016) ATP-induced P2X Receptor-Dependent Large Pore Formation: How Much Do We Know? Front. Pharmacol. 7:5. doi: 10.3389/fphar.2016.00005
Received: 30 November 2015; Accepted: 11 January 2016;
Published: 29 January 2016.
Edited by:Domenico Tricarico, University of Bari, Italy
Reviewed by:Yong Yu, St. John's University, USA
Copyright © 2016 Wei, Caseley, Li and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Lin-Hua Jiang, firstname.lastname@example.com;
Dongliang Li, email@example.com


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Former CBC radio host, Tetsuro Shigematsu says, "In my heart I knew I would always comeback to theatre and to telling my father's story in particular."
And tell his father's story he does in the upcoming play, Empire of the Son, at Richmond's Gateway Theatre.
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Agenda for the Week of 9/19
Hamlet - Act 2
- This is a SIP week, so you will be in class Monday/Tuesday/Wednesday
- Check your school email EVERY DAY
- All assignments are due on Sunday by 7:00 PM, except the initial discussion board post on Wednesday by midnight
- If your work isn't completed by 7:00 PM on Sunday, you are required to come in every day until it is done - graded or not
- Some assignments in this unit are for your benefit, but not for a grade. If you are concerned about doing well on the AP test, you are going to want to complete all work.
- There are many, MANY film versions of Hamlet. None of them cover the entire work, but they are mostly wonderfully done. I encourage you to watch them at some point during this 5-week unit.
Skills Covered
- Reading and analyzing a drama
- Analyzing elements of a tragedy
- Analyzing Shakespearean language
- Writing one-page responses
- AP-style multiple choice
Monday - Face to Face
-Download the play from this link
-Begin reading Act II in class
-Discuss Act II
Tuesday - Face to Face
-Continue reading and discussion
Wednesday - Face to Face
-Continue reading and discussion
-Initial discussion board post DUE TODAY by midnight - Respond to the question on Google Classroom. Responses should be analytical and use textual evidence where appropriate. (Aim for around 100 words minimum.)
Thursday - On Your Own
-Finish Act II on your own if necessary
-Audio version here if you prefer to listen
-Video version here if you prefer to watch (but stop before Act III!)
-Read two articles: "More on Hamlet" and "When in Doubt, It's from Shakespeare..."
Friday - Sunday - On Your Own
-Complete an LRJ for Act 1 (Due to Google Classroom by Sunday at 7PM)
-Complete Multiple Choice for Act II - It is a passage from Act I (bring answers to class Monday)
-Respond to at least one classmate's initial post by Sunday at 7PM. Responses should be analytical and use textual evidence where appropriate. (Aim for around 100 words minimum.)


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Cooperation vs. Deliberation: CMC and the Problem of Argument in International Distance Education
Michael Davis, Albert Rouzie
IRRODL Volume 3, Number 1, ISSN 1492-3831 Publisher: Athabasca University Press
The idea that Internet-based distance education offers the potential to globalize higher education has not been matched by significant interest in the pedagogical and methodological issues at stake. This essay discusses a two-year experimental course conducted between two college classes in Karlskrona, Sweden and Ohio, in the United States. The goal of this course was to use online debate to augment intercultural understanding. This experiment involved both synchronous and asynchronous computer mediated conferencing (CMC) as well as various types of assignments intended to emphasize the discursive strengths of each CMC form. We discovered, however, that our assumptions about CMC discourse were challenged by the way it developed in our international contexts. Ultimately, we developed and propose a methodology that delimits and makes productive the playful agnostics of synchronous debate by employing asynchronous conferencing for the pre-debate development of common ground and the post-debate development of formal arguments. Key Terms: MOO, asynchronous conferencing, international education, collaboration, conflict, argumentation, American studies.
Davis, M. & Rouzie, A. (2002). Cooperation vs. Deliberation: CMC and the Problem of Argument in International Distance Education. The International Review of Research in Open and Distributed Learning, 3(1),. Athabasca University Press. Retrieved May 27, 2019 from https://www.learntechlib.org/p/49525/.
ReferencesView References & Citations Map
- Garfinkel, H. (1967). Studies in Ethnomethodology. Englewood Cliffs, N.J.: Prentice-Hall. Garrison, Randy. (2000). Theoretical Challenges for Distance Education in the 21 ¡SUP¿ st Century: a Shift from Structural to Transactional Issues." International Review of Open and Distance Learning 1.1: P. 1-17. [Online]
- Sweden. (1986). The Swedish Immigration Board. Sweden: a general introduction for immigrants. Norrk¨oping: The Swedish Immigration Board. Trindade, Armando Rocha, Hermano Carmo & Jos´e Bidarra (2000). "Current Developments and Best Practice in Open and Distance Learning." International Review of Research in Open and Distance Learning 1.1: P. 1-25.
These references have been extracted automatically and may have some errors. Signed in users can suggest corrections to these mistakes.Suggest Corrections to References
Cited ByView References & Citations Map
How interpersonal- and classroom communication interventions can affect online cooperative learning: An experimental study
Hannah Klautke & Cary Roseth, Michigan State University, United States
Society for Information Technology & Teacher Education International Conference 2016 (Mar 21, 2016) pp. 274–277
A Review of e-Learning in Canada: Rejoinder to Commentaries
Philip Abrami, Robert Bernard, Anne Wade, Eugene Borokhovski, Rana Tamin, Michael Surkes, Dai Zhang & Dai Zhang
Canadian Journal of Learning and Technology / La revue canadienne de l'apprentissage et de la technologie Vol. 32, No. 3 (Oct 15, 2006)
Student Participation in Online Debates Within and Across Course Offerings
Gayle V. Davidson-Shivers, University of South Alabama, United States; Tuangrat Sriwongkol, King Mongkut's Institute of Technology North Bangkok, Thailand; Crystal A. Thomas & Stephanie McLendon, University of South Alabama, United States
EdMedia + Innovate Learning 2008 (Jun 30, 2008) pp. 3687–3694
How do female students perform in online debates and discussion?
Gayle Davidson-Shivers, Holly Ellis & Kay Amarasing, University of South Alabama, United States
E-Learn: World Conference on E-Learning in Corporate, Government, Healthcare, and Higher Education 2005 (October 2005) pp. 1972–1977
These links are based on references which have been extracted automatically and may have some errors. If you see a mistake, please contact email@example.com.


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That doesn' t need a button. Try using Mitsubishi codes if the Polaroid codes for Direct TV don' t work.
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We might just have an easy solution up our sleeve! Fix a Stuck Button on Your Smartphone or Tablet [ How- To] - YouTube Resetting an Android smartphone or a tablet is not very hard, especially, if there is a home button on your device.
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It said I had insufficient memory, which I found odd, because u knew I had more than enough memory, so I tried to reset, now I' m stuck. ( All other buttons are working.
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It is not the whole tablet, only the part described. If any functions are not working, try using the Auto- Search Programming Method below.
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Eco Travel Neti Pot Starter Kit
Contains everything needed for a daily nasal wash routine. The Himalayan Institute introduced the Neti Pot in 1972. Our trademarked lotus design and distinctive shape dispenses the perfect rate of flow to optimally cleanse the sinus passages.
Starter Kit Contents:
Non Breakable Eco Neti Pot
Neti Wash Plus
Eco salt jar
Why a Nasal Wash?
The nasal passages are lined with a thin layer of mucus that is one of our body?s first lines of defense against disease. A nasal wash keeps this layer of mucus moist, clean, and healthy. Compared to other nasal wash techniques, using the Neti Pot is easy. A nasal wash can be as routine as brushing your teeth.
Use it anytime to:
Remove excess mucus due to congestion
Rid nostrils of pollen and other allergens
Cleanse the nasal membranes of dust, smoke, or other airborne contaminants
Relieve nasal dryness due to air travel
Improve flow of breath before doing relaxation or meditation techniques
Eco Neti Pot
Made from petroleum-free, natural bioplastic, the Eco Neti Pot is perfect for travel and made with the same trademarked lotus design and distinctive shape as our original pot.
Eco Neti Salt Jar
Refillable eco jar for use with the sinus cleansing system. How can salt be eco friendly? This refillable 10 oz jar and perfect measure spoon are made from Ingeo, a plant-based, petroleum-free material. Neti Pot Salt is 99.99% USP grade salt, the highest purity salt commercially available. It contains no additives or anti-caking agents. Add one perfect measure spoonful of salt to 8 oz of warm water in your neti pot.
Neti Wash Plus Daily Neti Pot Boost
Neti Wash Plus contains 4 herbal extracts, essential oils of Peppermint, Eucalyptus, and Menthol to mildly cleanse and soothe the sinuses. This unique formula helps to nourish and moisturize your nasal passages and provides anti-microbial properties to support the health of your sinuses. The herbal extracts, essential oils, and Xylitol cool, decongest, and invigorate.
Suggested Use
Using your Neti Wash Neti Pot
1. Add 1/4 teaspoon of Neti Salt and warm water to your Neti Pot.
2. Lean forward and turn your head to the side.
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4. Raise the Neti Pot gradually so the saline solution flows in through the upper nostril and out the lower nostril. Breathe through the mouth.
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Third- through fifth-grade students at F.E. Bellows Elementary School are using the power of dance and movement to tell stories and gain a deeper appreciation for the Chinese and Indian cultures.
As part of a 10-week multicultural appreciation and enrichment program, they've welcomed two dance companies to their school – the Ajna Dance Company, renowned for preserving and performing traditional Indian dance forms, and the New York Chinese Cultural Center, which focuses on Chinese dance forms. A total of 120 students are experiencing free dance lessons during their lunch periods in March, April and May.
"Cultural dance movement has symbolic meaning which increases students' connections to the myths and aesthetics that make each nationality unique," said Dr. Valerie Feit, K-12 enrichment coordinator and co-director of counseling and guidance. "As part of our innovative Seekers and Solvers program, Dance Parade brings social studies content to life."
Feit added that the dance lessons encourage students to be physically active, while providing them with complex cultural expressions. Feit coordinated the visit along with F.E. Bellows Principal Michael Scarantino.
Fourth-grader Grayson Findlay, who recently experienced the Bharatanatyam, a classical Indian dance form, said she enjoyed learning all the hand movements.
"It's really fun to learn different cultures' music and dancing," Findlay said. "I love dancing and it's fun."
Parents are invited to join the upcoming dance classes, which will take place during lunch hours on March 19 and 26, as well as on April 9, 16, 23 and 30, and May 7 and 14. The classes culminate in an invitation for students to participate in the 12th annual Dance Parade NYC and Festival on May 19, along with the teaching artists. Dance Parade NYC, which takes place annually in New York City, features 10,000 dancers who perform traditional and contemporary dance genres. Last year, 30 F.E. Bellows Elementary School students and parents joined the Mazarte Dance Company during the parade.
Students and parents, whether involved in the dance classes or not, are welcome to participate in Dance Parade NYC. A parent information meeting will be held in the F.E. Bellows Elementary School library on April 9 at 6:30 p.m.
For more information about Dance Parade NYC, visit www.danceparade.org. Any questions, contact Dr. Valerie Feit at email@example.com.


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Those with a higher education will stand out against their competitors, making them more marketable for higher-paying jobs.
Hoboken, NJ (PRWEB) April 2, 2008
Although most economists say the United States is not in a recession, the pocketbooks of many Americans would say otherwise. In fact, a recent CNN/Opinion Research Corp. poll found that the majority of people in the U.S. believe we are now in a recession and inflation is their top concern. In the face of economic struggles, eLearners.com, a web resource of EducationDynamics that connects prospective students with online colleges, is seeing an increase in requests for information on online MBA degrees.
"In tough economic times people with an MBA or other advanced degree are often the ones that come out ahead," said Terrence Thomas, Chief Marketing Officer for eLearners.com. "Those with a higher education will stand out against their competitors, making them more marketable for higher-paying jobs."
According to the U.S. Census Bureau, a higher level of education equals higher overall lifetime earnings. Census Data projects that a professional degree holder (e.g. lawyer or doctor) will earn $4.4 million in the span of his or her career. The U.S. Census Bureau also found that people with an MBA or other advanced degree earned four times that of people with a high school diploma ($82,320 compared to $20,873 respectively).
"But, it's not just about about the money, particularly in recessionary periods," continued Thomas. "It's about employability."
A September 2007 College Board report titled "Education Pays" found that higher levels of education directly correspond to a lower unemployment rate. The average unemployment rate for people with at least a bachelor's degree was around two percent, while the average unemployment rate for high school graduates was nearly five percent.
To "recession proof" their employment, many Americans are seeking advanced degrees, such as an MBA degree, to solidify their current position or to switch careers entirely. People are also looking to education to tap into jobs that may handle the hard economic times better than others. Some of those fields include education, international business, security and healthcare. For people having to juggle a career and school, online colleges are a perfect fit because of their convenience and flexibility. eLearners.com lists the following as its top ten most requested online master's degrees: Business Administration, Counseling, Psychology, Health Administration, Criminal Justice, Nursing, Curriculum and Instruction, Special Education, K-12 Education and Educational Leadership.
In addition to serving as a comprehensive resource on online graduate degrees, eLearners.com recently launched a Guide to Online Graduate Schools to walk students through the selection and application process. The site, which features simple-to-navigate, concise and in-depth information, is located at http://www.elearners.com/guide-to-online-education/guide-to-online-graduate-degrees.asp.
For more information on eLearners.com, log onto http://www.elearners.com.
About eLearners.com®
The eLearners.com website is one of several high visibility, high-quality prospecting tools offered by EducationDynamics, LLC. Since 1999, eLearners.com has been successfully connecting learners to online education, including online mba programs as well as online degree and certificate programs, specialized career training, and a variety of online courses. For prospective students, eLearners® provides a powerful search engine for users to find thousands of online program offerings, as well as educational evaluation tools and financial aid resources. For colleges and universities, the eLearners.com website offers a low-cost, performance-based method to provide national exposure and increase enrollments in their programs. For more information on eLearners.com, visit http://www.elearners.com.
About EducationDynamics
EducationDynamics, a portfolio company of Halyard Capital, is the leading marketing and information services company dedicated to helping higher education institutions find, enroll and retain students. Its content-rich and highly visible education websites, including EarnMyDegree.com, eLearners.com, GradSchools.com, StudyAbroad.com, and its more than 50 special interest microsites, make EducationDynamics the premier provider of qualified prospective students for colleges and universities. In addition, the company offers a full suite of web-delivered services proven to drive enrollment growth and reduce student attrition. For more information, visit http://www.educationdynamics.com.


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There have been requests for ways to assist the migrants that are in the Central American Caravan in Tijuana. The city of Tijuana has reported that they are needing assistance to provide basic needs to the men, women and children who are there. There are people who need help. If you would like to help the United Nations Association of the USA had set up a drop off location for those that want to donate. The location is:
San Diego: (UN Association San Diego) 2171 Pan American Plaza, UN Building, San Diego, CA 92101. Hours are 9:45 am to 4:45 pm