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AbbVie, Bristol-Myers Squibb, Genentech, Janssen and Merck & Co. have all advanced anti-tau candidates into Phase I trials in the hunt for drugs that can modify the course of Alzheimer disease.
Image: Ikon Images/Alamy Stock Photo
Because disease-modifying candidates for Alzheimer disease (AD) have had a 100% failure rate in Phase III development to date, it came as little surprise that TauRx's candidate LMTM recently flopped in the first-ever pivotal trial of a tau-targeting therapy. The drug, a derivative of methylene blue developed to reduce the formation of the tau tangles that are one hallmark of AD, showed only a hint of possible efficacy in a small and controversial subgroup analysis presented at the Alzheimer's Association International Conference in July. But many researchers are ready to dismiss the drug's failure as a minor speed bump, unconvinced that the trial properly explored the role of tau in neurodegeneration.
"I need more evidence to throw out this mechanism"
"There are so many different reasons a drug could fail to hit its end points. It could be that the drug candidate wasn't good enough, it could be that the trial design was incorrect, or it could be that the mechanism is wrong," says James Hendrix, Director of Global Science Initiatives at the Alzheimer's Association. "But I need more evidence to throw out this mechanism."
Industry researchers agree. "The results of this trial don't change our enthusiasm for going after tau," says Sean Smith, Director of Neuroscience at Merck & Co.
Fuelled by the lack of success with candidates that target the formation of the amyloid-β plaques, as well as the emergence of tau-imaging tools that can track the accumulation of tau in living brains, the anti-tau pipeline is growing. Big pharmaceutical companies have advanced at least five anti-tau therapies into Phase I trials in recent years, experimenting with an assortment of vaccines, antibodies and small molecules.
Anti-tau alternatives
Tau is a microtubule-associated protein that forms tangles inside neurons in several neurodegenerative diseases, including AD. Whereas the field was once divided over whether tau or amyloid-β species were the more important driver of neuronal death in AD, it is increasingly embracing the idea that the two might interact in a toxic pas de deux (Nat. Rev. Neurosci. 12, 67–72; 2011). Because tau exists in multiple intracellular and extracellular forms, traffics through the brain in a predictable manner and needs to be hyperphosphorylated before it can form tangles, drug developers are investigating a range of different tau-targeting strategies.
One of the most advanced of these approaches are vaccines that can induce immune responses to help patients clear their own tau. Janssen and AC Immune's ACI-35 raises an antibody response to a phosphorylated form of tau, and first entered into Phase I in 2013. Results are expected next June. Axon Neuroscience recently advanced its AADvac1 into a Phase II trial, having reported that their candidate, designed to elicit a response to pathologically modified forms of tau, was safe in a Phase I trial.
A potential strong point of vaccines is that they could provide long-term protection. And given that tau tangles also start to accumulate years before the diagnosis of disease, cost-effective preventive approaches offer a clear appeal.
Another approach is to focus on therapeutic antibodies, which can be more precisely fine-tuned to target different forms of tau and to control the subsequent immune response.
In 2014, Bristol-Myers Squibb advanced its anti-tau antibody BMS-986168 into a first Phase I trial in healthy volunteers. The antibody, acquired from the biotech iPierian, was discovered by using induced pluripotent stem cells derived from AD patients (Nat. Rev. Drug Discov. 14, 589–591; 2015). BMS-986168 targets extracellular N-terminally fragmented forms of tau.
The company has since launched another Phase I trial testing the antibody in patients with progressive supranuclear palsy (PSP). PSP is a 'pure' neurodegenerative tauopathy that is not accompanied by amyloid aggregation, and is considered to be a clean way to test the efficacy of anti-tau antibodies in a less complex disease setting. The trial is due to complete in the middle of next year.
AbbVie, similarly, started testing its anti-tau antibody C2N-8E12 in the summer of 2015 in a Phase I trial in PSP. Its antibody, licensed from C2N Diagnostics, targets aggregated, extracellular tau.
And this July, Genentech announced that it had advanced an anti-tau antibody into a first Phase I trial. The trial will test the antibody RO7105705, developed with AC Immune, in patients with mild to moderate AD and in healthy volunteers.
The use of antibodies against central nervous system (CNS) targets, as always, raises a specific challenge: getting enough antibody to cross the blood–brain barrier to exert a therapeutic effect. In the case of tau, this is further complicated by the fact that toxic tangles are intracellular, typically beyond the reach of antibody therapies.
Genentech's Gai Ayalon, however, thinks that access problems are manageable. His recent work suggests that, contrary to previous reports, anti-tau antibodies bind to extracellular tau, as it is trafficked between neurons, rather than to intracellular tangled tau (Cell Rep. 16, 1–11; 2016). "Anti-tau antibodies don't enter neurons and they don't bind intracellular tau. We've invested a lot of careful rigorous work to try and understand this and I hope that the field will agree that we can put to rest that question," says Ayalon. Because extracellular tau levels in the CNS are thought to be relatively low, he adds, even poorly penetrant anti-tau antibodies may get past the blood–brain barrier in high enough quantities to mop up significant amounts of the trafficking tau that might otherwise seed the accumulation of further tau tangles. This is different from the situation with amyloid-β, he adds, in which antibodies act on brains that are riddled with extracellular amyloid-β.
This same paper also found that an antibody can deplete tau even when its effector function — which activates subsequent immune cell responses in the brain — is turned off. (Effector function was turned off by mutating the antibody's Fc region.) "This was an exciting and surprising finding," says Ayalon, because it suggests that anti-tau antibodies need not induce chronic inflammation in already inflamed AD brains.
Merck & Co. is taking a different approach, working with partners Alectos to develop a small-molecule-based indirect attack on tau. Because tangle formation depends on the hyperphosphorylation of tau, their strategy is to control the post-translational processing of tau with the sugar tag O-linked N-acetylglucosamine (O-GlcNAc). O-GlcNAc is physiologically added to tau at the same residues at which hyperphosphorylation occurs. By inhibiting protein O-GlcNAcase (OGA), the enzyme that cleaves O-GlcNAc from post-translationally modified proteins, their plan is to leave the tag in place, prevent the hyperphosphorylation of tau and thereby reduce the development of tangles.
The partners have completed a Phase I trial of their OGA inhibitor, MK-8719, in healthy subjects. Joe Herring, Executive Director of Clinical Neuroscience at Merck, says the next steps will include Phase II trials in PSP. Success in that indication could pave the way for further research in AD and other tauopathies.
Several companies have worked to develop small-molecule drugs against glycogen synthase kinase 3 (GSK3), which phosphorylates a number of the hyperphosphorylated tau sites, as an alternative means of modulating tau's post-translational modification. Noscira made it as far as a failed Phase II trial in 2012 with its GSK3 inhibitor, and subsequently went into liquidation. Other companies, including Sanofi and AstraZeneca, have discontinued projects against this target.
Picking patients
As with anti-amyloid treatments, researchers still need to figure out which AD patients might benefit from an anti-tau treatment. Repeated failures in Phase III trials of anti-amyloids have pushed trials into earlier and earlier stages of disease (Nat. Rev. Drug Discov. 11, 657–660; 2012). Amyloid starts building up around 20 years before AD is diagnosed, and brain levels of amyloid are close to being maxed out by the time cognitive decline begins. Anti-amyloid treatments, the theory goes, therefore need to be started years if not decades before the onset of cognitive decline.
Tau might offer a different treatment window because its accumulation tracks more closely with cognitive and functional decline. Tau levels are still on the rise at the time of disease diagnosis. "That makes tau a more attractive target," says Keith Fargo, Director of Scientific Programs at the Alzheimer's Association. "By the time you see somebody with a headful of amyloid it may be too late to slow down the amyloid accumulation, but by going after tau in these patients we may still be able to stave off dementia symptoms."
At the same time, cautions Ayalon, anti-tau drugs (and anti-amyloids, for that matter) aren't designed to bring dead neurons back to life; at best, they might slow the decline of ailing axons. "We have to be realistic. As patients progress through the disease, the therapeutic effect of drugs is likely to decline," says Ayalon.
With most anti-tau candidates still only in Phase I trials, companies have not yet disclosed where they think the sweet spot is for mid- and late-stage trials of these drugs. But all options are open. Randall Bateman, of Washington University in St Louis, USA, says that he is considering adding an anti-tau therapeutic arm to the DIAN-TU trial, which is testing drug candidates as preventive therapies in a population of largely asymptomatic people at high risk of early-onset disease.
"I'm very much looking forward to seeing what the future holds with all these approaches," says Ayalon. "I hope our hypotheses for tau pan out."
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Further reading
2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling
Molecular Neurodegeneration (2018)
Clinical Research on Alzheimer's Disease: Progress and Perspectives
Neuroscience Bulletin (2018)
Tau-based therapies in neurodegeneration: opportunities and challenges
Nature Reviews Drug Discovery (2017)


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Japanese centenarian population edges towards 70000
Japan Japanese centenarian population edges towards 70,000
Number of people aged 100 or older reaches record high, with women making up 88% of total
The number of Japanese people aged 100 or older has risen to a record high of almost 70,000 over the past year â" a cause both for celebration and concern over the social and economic challenges posed by the countryâs rapidly ageing society.
Japanâs cent enarian population was 69,785 as of September, with women making up 88% of the total, according to welfare ministry estimates reported by Kyodo News.
The number is up by more than 2,000 from last year, and marks the 48th annual increase in a row. Japan had just 153 centenarians when records began in 1963, and as recently as 1998 the number stood at just 10,000. It surpassed 30,000 in 2007, rising to almost 68,000 last year.Japanese centenarians' honorary gifts hit by austerity as numbers soar Read more
The data was released before Respect for the Aged Day on Monday, a public holiday when new centenarians â" including the former prime minister, Yasuhiro Nakasone â" will receive a commemorative sake cup and a letter of congratulations from the current prime minister, ShinzÅ Abe.
The dramatic rise in the number of people making it to their 100th birthday forced the government to reduce the diameter of the gift â" a sakazuki â" in 2009. Two years ago, the sterling silver cup was replaced by a cheaper silver-plated version to lessen the strain on government coffers.
The cost of honouring Japanâs super-elderly will continue to rise, however. The number of centenarians will exceed 100,000 in 2023 and reach 170,000 five years later, according to estimates by the National Institute of Population and Social Security Research.
Japanese women have the longest life expectancy, at 87.2 years, while men rank just below Switzerland and Australia at 81.01 years, according to a study published in the British Medical Journal last month.
Kane Tanaka, who is among the candidates seeking official recognition as the worldâs oldest woman, was born on 2 January 1903 â" the year the Wright brothers flew the first powered aircraft and Maurice Garin won the first Tour de France.
Tanaka, who lives in a nursing home in the south-western city of Fukuoka, enjoys playing board games and solving maths prob lems, Kyodo said, and has a taste for sweet bean buns and milky coffee.
Her compatriot Masazo Nonaka was recognised as the worldâs oldest living man in April after the death three months earlier of Spainâs Francisco Nuñez Olivera. Nonaka, who lives in an inn he once ran in Hokkaido, northern Japan, was born on 25 July 1905, the year the Russo-Japanese war ended and Albert Einstein published his theory of special relativity.
Nonaka attributes his longevity to bathing in hot springs and eating sweets, but his daughter puts it down to his stress-free life, according to Guinness World Records.
Experts have attributed the steady rise in the centenarian population to regular medical examinations, universal healthcare and, among people over a certain age, a preference for Japanâs traditional low-fat diet.
But Japanâs super-ageing society is expected to put even greater strain on health and welfare services as the countryâs working population continues to shrink as a result of the low birth rate.
Abe, who described Japanâs demographics as a national crisis during last yearâs general election, has vowed to reform social security to allow workers aged 65 or older â" who account for one in four of the countryâs 127 million people â" to stay in employment beyond the retirement age.Topics
- Japan
- Older people
- Asia Pacific
- news
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West Pines Hospital
Adolescent Rehab Unit
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Guardians of the Republic › Forums › The Saloon › General Discussion › Range Time? › Reply To: Range Time?
September 1, 2018 at 8:29 am #90148
What's up Mad Duner, are you from California? Glamis dunes?
As for range time we love it but where I live in lake Elsinore it seems last couple years riverside county has shut down our local shooting spots and we have increased BLM enforcement as well as sheriffs kicking us out and taking pictures of our vehicles for their portfolios.
Guess California want all of our guns and skills to rust up!


text: It is unclear to me how to find my own posts. I've been trying to search for my username, ERock, but even that doesn't find them all. Am I just missing an option? Nevermind found out that going to 'My Profile' has it. I thought that clicking your username at the top was going to your profile.


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Super Regionals for the NCAA Division I Baseball Championship will be held June 8-10 on eight campus sites, and you can catch all the action at the best sports bar in New Orleans, the The American Sports Saloon, 1200 Decatur.
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Email | Location | Website | 01599 544255


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Rex Fowler tours with a new lineup after the retirement of longtime bandmate Neal Shulman
After more than four decades, Aztec Two-Step, a name intertwined with the history of folk/rock music in America, is stepping out with a new sound as it looks forward to new horizons of creating music.
One of the original members of the duo has retired, causing the music of the recast Aztec Two-Step to develop an original bent, even as it performs tunes created by the legendary folk duo, which originated from a chance meeting at a Boston folk club open mic in 1971.
That meeting was between Rex Fowler and Neal Shulman. Shortly thereafter, they formed Aztec Two-Step, named after a Lawrence Ferlinghetti poem. Their self-titled album was released in 1972. That first album, and their three subsequent albums for RCA Records, made the duo staples of progressive FM and college radio, helping to usher in the folk music era.
Fowler and Shulman created nearly 20 albums, the most recent, "Naked" in 2017. Along the way, they shared stages and stories with The Beach Boys, The Band, Bruce Springsteen, Talking Heads, Michael Bolton, Bon Jovi, Randy Newman and others.
But with Shulman's recent retirement, it's a new era for Aztec Two-Step. And with his former partner's full support, Fowler is continuing on with "Aztec Two-Step Featuring Rex Fowler & Friends," which will perform on Saturday, Feb. 16, at the Narrows Center for the Arts in Fall River.
The foundation of the new Aztec Two-Step is the partnership of Fowler and Dodie Pettit, who wed in August.
"We've been on cloud nine," Fowler said in a recent phone interview from the couple's home in Westport, Connecticut. "Dodie has worked so hard to learn the songs and it brings a whole new energy and sound. It's really quite exciting."
Pettit, who developed her stage presence on Broadway, literally electrifies the music of Aztec Two-Step, playing electric and acoustic guitar and keyboard in addition to singing. Her Broadway credits include "The Phantom of the Opera," where she worked her way up from performing as a dancing ballerina on opening night in 1988 to eventually the co-lead role of Christine. She also appeared in "Cats" on Broadway. Between the shows, she has more than 4,000 Broadway performances to her credit and has done extensive touring with national productions.
As a guitarist and songwriter, Pettit, a former principal dancer for the American Repertory Dance Company, has worked with pop/rock bands and recorded two solo albums.
She first met Fowler in 1979 when she did session work for Aztec Two-Step's album "Times of Our Lives." She played lead guitar on one of the songs and sang background.
"Over the years, we stayed in touch," Fowler said.
In 2013, Pettit's husband, Kevin Gray, a popular Broadway actor whose roles included the Phantom in "The Phantom of the Opera," died of a heart attack at the age of 55. Fowler, who was married for a few years in the 1970s, had moved to Connecticut and eventually reconnected with Pettit.
For the Narrows Center concert, Aztec Two-Step will be rounded out by Steven "Muddy" Roues on upright bass, blues harmonica and vocals; Peter Hohmeister on drums, percussion and vocals; and Rob Aries of Average White Band on keyboards.
"Whenever possible, we're trying to reproduce what we did on recordings, with less emphasis on two-part harmony," Fowler said. "We're expanding it to three- and four-part harmony and just trying to go out and have a lot of fun with the music and move away from the total acoustic feel that Neal and I basically survived on all those years."
He has adjusted well to Aztec Two-Step's new stage presence.
"Neal was an integral part of the show and one of the best acoustic guitar players in America," Fowler said. "His stage presence was very droll. We played off each other."
Things are quite different now, with Pettit added to the mix.
"Dodie is an amazing woman and she gets out there and just blows the room away," Fowler said. "Nobody is expecting this 5-foot-4, 100-pound former ballerina to get out there and rip it up on the electric guitar. It's really a lot of fun to see the reaction she gets."
The band has about 30 songs it performs live.
"It's a lot of fun to revisit some of these songs and we'll be doing more and more of that," Fowler said. "You can't just run a song down one time and get out on stage and expect to have the nuances that you need to pull a song off live. It requires a lot of preparation."
Fowler, 71, has no plans of slowing down as he looks forward to creating music and sharing his life with Pettit.
"We're just doing it for the joy right now," he said. "Every day is a blessing."
If you go ...
What: Aztec Two-Step featuring Rex Fowler & Friends
Where: Narrows Center for the Arts, 16 Anawan St., Fall River
When: Saturday, Feb. 16, 8 p.m.
Tickets: $30 advance, $35 day of show
Information: (508) 324-1926, narrowscenter.org


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The First Wives Fight Club
About First Wives Fight Club
The first rule of First Wives Fight Club...? TELL EVERYONE!
Peaches Christ is teaming up with the gorgeous and indelible talents of Raja, Brooke Lynn Hytes, Ginger Minj, and many more to bring you a live musical parody mash-up of the now-classic films, "First Wives Club" and "Fight Club." You've never seen (or heard!) anything like it!
Platinum Peach Ticket includes:
- Seating in rows B, C & D center section
- An Event Program autographed by the cast
- 2 Complimentary Cocktails
- First in line for Meet/Greet with the cast
- Early entry to the event
- $5 off exclusive FIRST WIVES FIGHT CLUB t-shirt
VIP Ticket, includes:
- Seating in the VIP section
- Meet/Greet with the cast
Unlike past Peaches Christ Productions, this event will NOT be followed be a movie screening. A ticket purchase is for the stage show exclusively.
Doors open 90 minutes before showtime for Platinum Peach & VIP ticket holders and 1 hour before showtime for Orchestra and Balcony ticket holders.
Run Time
Start Date
End Date
Recommended for ages 13 and up.


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Waterbased Inks for DIY Printing
Here you will find all the Waterbased Inks suitable for home use. These inks are the perfect solutions for printing at home or in a small print shop.
The range includes multiple water based colours from the ever so popular eco-friendly Amex. These inks are also Vegan friendly.
We put 100% into finding the best products for you and we are confident that these below are perfect for the job.
As always if you need any help, don't hesitate to ask. You can always leave a message on chat, give us a call on 01562 829009 or email firstname.lastname@example.com
- Display 15 Products per page


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FIAT 500 ABARTH MADNESS Power Trio (Red) - Engine Module, GOPedal & Intake Combo (2015 - on Models)
Have a question about this product?
In order to reduce errors in orders, please make sure the product you are ordering fits your vehicle model.
Call us at (888) 993-7552
and get assistance from one of our sales team members!
Product ID Number:
Purchase our most popular Power Trio and save BIG!
In addition, receive Free Shipping (Continental US) and an upgraded BMC Filter!
Power, Response and Savings!
This listing is for the 2015-on Model. Check our other listing for the Pre 2015 Model.
This listing includes the MADNESS MAXPower Engine Control Module, MADNESS GOPedal and the MADNESS Hi Flow Intake.
All three items are designed to deliver improved power and response. Wake up your 500 ABARTH with this Power Trio and save!
The MADNESS MAXPower Engine Control Module provides you with an affordable and proven way to give your 500 ABARTH more horsepower and torque. The ECM is completely Plug and Play and will instantly transform your 500 ABARTH. For more information on the MADNESS MAXPower Engine Control Module visit the product listings pages Here for Bluetooth Control, or Here for the Standard ECM.
The MADNESS GOPedal is designed to reduce initial lag, the GOPedal connects to your stock pedal assembly and allows you to choose between settings for different driving styles.
The MADNESS Hi Flow Intake is designed to provide your ABARTH with increased intake airflow and a more aggressive intake note. We are also upgrading the standard K%N Air Filter to the deluxe BMC Filter for no additional cost.
This Intake has quickly become the most popular intake for the ABARTH on the market. Check out the individual Intake listing for more details.
Get all three at once and save on purchase price and shipping!
Check out the individual listings for each product for more details.
The intake system in this listing is designed for the North American FIAT 500 ABARTH and 500 Turbo models.
Please note!
CARB Information:
In the interest of improved air quality, the California Air Resources Board (CARB) requires new vehicle and manufacturers of aftermarket parts to develop engine and emissions equipment that either reduce or maintain specific air pollutants affected by vehicle use. Both the California Vehicle Code (section 27156) and Federal Clean Air Act (administered by the Environmental Protection Agency) prohibit modifications that increase vehicle emissions.
Aftermarket parts manufacturers, particularly in the high-performance segment, are required to obtain CARB approval in the form of Executive Orders (E.O.s) for any product not qualifying as a direct replacement for an
original equipment part. This includes meeting all E.O. requirements in its product development process. This guarantees that users of this product will meet certification requirements when registering, selling, or needing to
pass various emissions tests or Inspection and Maintenance (I&M) programs administered by state or local enforcement agencies.
Make sure that any emissions-related product you buy and install carries an E.O. number or is pending an E.O. Without this verification you are at risk, in potential violation of regulations and may incur unnecessary financial obligations during vehicle inspections or emissions tests
Special Note for California Customers:
This part is not CARB Certified (California Air Resource Board) at this time and is not legal for use in California on pollution controlled vehicles.
If you are located in California please note that we have other options available that comply with the California Vehicle Code. Please contact us directly by phone, email or check our site for details.
Any California orders will be held for review if they contain this part. We will then contact you directly with options.
MADNESS Autoworks is your One Stop Shop for customizing, accessorizing and servicing your favorite ride.
Whether you are looking for custom wheels, window tinting, custom stereo installation or other performance modifications we are your shop.
MADNESS Autoworks is located in Signal Hill, CA (an enclave surrounded by the City of Long Beach) and is a facility dedicated to making your favorite ride truly yours by offering a wide line of aftermarket accessories, installation and customizing services.
MADNESS Autoworks was originally known as SMART MADNESS a company that became famous for customizing and accessorizing smart cars.
SMART MADNESS has become the largest provider of smart car parts, accessories and customizing services in North America and now one of the largest globally in just a couple of short years.
We accomplished this goal by providing the very best in products and services at reasonable prices with a personal touch. We treat our customers like family members and do our best to make sure every one of our customers gets the very best treatment possible.
A number of our customers own other cars besides the smart car and continuously ask us if we would also work and or customize their other car due to their positive experience with us. This is how MADNESS Autoworks was born.
Our goal is simple! Provide you, the driver with the widest range of products, servicing and customizing options with friendly service at a very competitive price.
After spending years working on cars and working with many suppliers we thought at times we could do better by designing and manufacturing some products ourselves. We started partnering up with our most trusted manufacturing partners and suppliers, investing in infrastructure, manufacturing equipment and recruiting some of the best talent that could help us design and build superior products and make them available to our fellow drivers.
Our goal is to provide a top quality product that has been tested and used in our own cars and has proven to last and provide a good value for the investment. Whether you are looking for the best value in a set of floor mats, a performance exhaust system, an intake, a roll cage or a carbon fiber part the MADNESS Item is designed to deliver on our promise of bringing a good quality item at a reasonable price. We do not design and build our products to be the cheapest, we design then to be the best value for the money and stand behind them the same way we stand behind our work.
If you ever have a question, need assistance or have a request contact us and we will be glad to help.
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Welcome to Antenas de Jalisco
Antenas de Jalisco is a Mexican Company specialized in manufacturing Parabolic Antennas and Radio Antennas. In the last few years we have innovated in Microwave technologies. We offer a wide range of products to solve your telecommunications needs. Each of our products is designed and manufactured in our factory under the highest quality standards which distinguish us.More
Our Antennas
Antenas de Jalisco is an antennas manufacturer with more than 38 years of experience in the market. We make a variety of antennas including: Parabolic Antennas, Radio Antennas and Point-to-Point Bridging Antennas.
Advantages of working with Antenas de Jalisco
of experience
the industry
Some of our clients
These are some of the companies that trust Antenas de Jalisco and use our antennas in their projects. Thanks to their quality and warranty, Antenas de Jalisco antennas are your best option.
Installation testimonials
We are committed to the quality in manufacturing and installing our parabolic antennas.
Learn more about our previous projects.
Contact us
Send us a message to learn more about our parabolic Antennas. Find our contact information and don't hesitate to call us.
Cuauhtémoc 17, Buenavista, Tlajomulco de Zúñiga CP 45640. Jalisco, México
Monday to Friday: 8 a.m. – 7p.m.
Tel. +52 (33) 3796 0808
Fax. +52 (33) 3796 0909


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The search engine giant, Google says it will ban all cryptocurrency related advertisement of every kind including wallets, initial coin offering, trading advice etc with effect from June 2018, as stated in their recent financial services policy update. Check also: Google reportedly offered $30 billion to buy Snapchat The search giant's cryptocurrency crackdown follows a similar ban that facebook did early ...Read More »
The Multi Biillionaire Elon musk To Provide Cheap Internet For Uganda
The multi billionaire Elon musk is set to provide Uganda with cheap internet through his consortium. And as a matter of fact, Ugandan internet is currently regarded as the most expensive in the region. We pray that Elon's initiative will help solve this challenge. Check also: Meet Musk, The Founder Of Tesla Motors The president of Uganda has already met with ...Read More »
Stanbic Bank Uganda and Uganda Revenue Authority Makes tax payment Easy
All Tax payers are now able to pay their tax duties by using VISA, MasterCard and MTN Mobile money the secure convenient and affordable online method that is launched by Stanbic bank together with URA (Uganda Revenue Authority). Check also: Uganda Could Get Rich On Oil, According To World Bank The online platform is easily accessed by both Stanbic and ...Read More »
Why Vodafone Is the Difference
Vodafone is the first ever Telecommunication network in Uganda to have a fully functional 4G network as the standard for customers accessing the network. Check also: Top 10 Countries With The Fastest Internet Speeds The network provides TD-LTE 4G which is proven to offer superior performance, and quality of service. You can enjoy ultra-Fast 4G Internet with faster download speeds and faster ...Read More »
What You Need To Know About Samsung Galaxy S9
Some people that have used Galaxy S8 say that it's one of the best and stylish smartphone in the world, but that might not be the case. The upcoming Galaxy S9 together with its fantastic brother, Galaxy S9 Plus might be more sophisticated and too stylish, though there's a lot we haven't hard about the upcoming smartphone. Check also: Samsung's Galaxy ...Read More »


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Axis Bank to Aam Aadmi Party to Uber CMO...Marketing
Karan Bedi
CEO, MX Player
A media conglomerate launching its digital video platform in India is nothing new. Streaming platforms launching original shows for netizens to stream has also become a norm. However, this is probably the first time a platform will launch with 175 million monthly active users and 70 million daily active users in India. Times Internet recently acquired one of the largest local video players on the market - MX Player and has formally launched its OTT avatar.
In June 2018, Times Internet invested about Rs 1000 crore to acquire a majority stake in South Korea headquartered MX Player. MX has been an extremely popular video-playing app for Android devices since it is capable of playing all possible video formats. Times Internet claims that the app is installed in one of every two smartphones in India. Later, in October 2018, MX added streaming technology to the app and users were offered content licensed from various platforms like - SonyLIV and TVF Play among others.
Starting tomorrow, the platform will release original shows which can be streamed for free. Karan Bedi, CEO, MX Player is excited about the new avatar and shared his thought with us in a quick interview:
Edited Excerpts
How has life changed for MX Player after its acquisition by Times Internet?
After the acquisition, we have had to build a team from scratch. The streaming technology was put into place first and then the content team got in on the action, followed by the sales unit. It was a 10-member engineering team before MX Player was acquired by Times Internet and now there are 230 people spread across offices (Mumbai, Gurgaon and Bangalore). The last 12-15 months has been a tough, but very exciting journey.
While you had a huge number of people using MX Player, for them, it is a video player that plays downloaded videos; how big a challenge is it for you to change their perception as you are now positioning MX as an OTT platform?
We thought it would be a big challenge, but it turned out to be quite the opposite. The app has been live for a few months now, we had done a soft launch in 2018 and we have passed all our conversion targets. The whole thesis behind buying MX was - people are spending so much time-consuming video; can we offer them content so that they can stream instead of downloading - and I would say we have done it very successfully. We are already one of the biggest OTT platforms in the country.
There are already more than 30 OTT platforms producing 'Originals'; there is user-generated content on YouTube and Facebook; how do you plan to differentiate?
We are not following the same crime-crime-crime route. We will offer differentiated content which lives up to our tagline - 'Jaisa Mann, Waisa Manoranjan'. So, the first aspect that differentiates us from others is our differentiated content offering. Second is the scale; the scale at which we deliver is certainly far bigger than others in this space. Different audiences like different kinds of shows. If you look at the statistics, after the introduction of the Internet and digital, the time spent on media has only gone up. Digital did not cut into TV or films, but it has added to it; so I don't see the clutter as a problem.
With MX Player's new avatar, which are the markets you are going after? How will you define your target audience?
Language-wise we are going after lots of markets. We have announced Originals in Hindi and Tamil; we have Marathi, Bengali, and Punjabi among many other vernacular languages as well. We have content spread across genres like - Politics, Biopics, Romance, Comedy etc., so we are targeting a wide range of audiences. In the initial stages, we will target the 18 to 30 age group - the millennials across India.
You defined your shows as premium content and you are making it available for free...
Right now I don't think India is quite ready for an SVOD model. We want Indian consumers to watch premium content for free. That is also our big differentiator. The idea is to let the Indian streamers land on the platform, sample and experience what it is about. Eventually, we will see if it is SVOD, TVOD or any other new model that works well in India.
The genres you are playing are not familiar grounds for advertisers; crime and politics are not genres advertisers endorse on TV?
The other way of looking at it is that such shows were never put on television. This is what the youth - the millennial is watching today. Also, none of our content is offensive; they are all brand safe.
Do you have enough advertisers willing to spend on digital video for your investment to make economic sense?
We already have more than 30 brands on our platform advertising in many different ways. We have Google, SBI, and Nerolac among others; from BFSI to FMCG. We will have brands integrated into the content, we will have ad breaks within our shows and we will have other inventories too. The perception that you cannot do premium shows on AVOD is because others do not have the scale. If you have scale, you can make money on AVOD.
Your rivals in the AVOD space very much ride on catch-up TV and content around content; you do not have the luxury of catch-up content...
We are partnering with broadcasters for catch-up TV on our platform. We have all the content from Sony Pictures Networks Limited. Yes, catch-up TV drives a lot of consumption and we are in talks with other networks too. Apart from that, we have 150 channels across various categories like News and Music and all are simulcasting live on the platform. Another advantage that we have that others don't is Gaana. MX Player consumers can access the entire Gaana library within the MX interface - so, this is us saying, hey, why do you need to go elsewhere when you can have everything here.
Where would you like to see MX Player at the end of 2019?
By the end of 2019, I would like to see MX Player as the number one OTT platform in the country.


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The region
Not to leave you with an incomplete picture, allow me to
supply you with a number of very informative links to our beautiful
Enjoy !!
Koksijde's official website , distributing some
remarkable brochures.
A general information about the " Westhoek"
Some views of
is the weather now in our city??
A nice and hot
place for tonight ??
Coming soon !!


text: On 10/4/10, Michael Meeks <michael.meeks at novell.com> wrote: > Hi Norbert, > > So - first ... thanks for your great set of patches, it is nice to see > clean-ness trickling into the code :-) I reviewed, built, tested, and > merged these patches: > > * Convert all virtual functions QueryValue() and PutValue() to > return bool instead of a mix of BOOL and sal_Bool - ~1Mb ;-) > > * native bool support in SvXMLUnitConverter and connexe > bool-related-issues > > * harmonized some headers with implementation regarding BOOL > vs sal_Bool use. > > Which all looked great. They all looked good. Of course, for this task > we should be a bit careful about UNO compiled methods which use sal_Bool > - although, I suspect that even they would cause little trouble [ but > breaking the ABI related assembler binary bridges would be a little > unfortunate ]. My goal is to push sal_Bool (i.e bool as unsigned char) as much as possible to the boundary. But I'm not sure where that ABI boundary is. Is there a document somewhere that explain what is the ABI (IOW what interfaces are 'ABI public' versus interface used only internally > > Anyhow - I didn't merge this: > > * Add support for bool for the operator << and >> of SvStream > + didn't apply this one: do we really need it (yet?) > + was concerned about accidental usage really. The way I am proceeding is to change typedef sal_Bool BOOL to typedef bool BOOL and then compile, find problems, fix them, then change back the typedef re-compile - to make sure that there are still no problem and make a patch with the change so far Without the support of << >> fo bool, this is the first thing that break and I would have to re-patch them every time to move forward (and not forget to undo it before submitting a patch... Eventually this will be needed anyway and in the mean time, while BOOL is typdef'ed as sal_Bool this is without impact. > + also, sizeof (bool) is not a good idea; if we are > writing to a binary stream, we want a fixed size eg. > a char on every platform, and not to change the binary > format (of course). Yes good point. I didn't realized then that sizeof(bool) is not specified by the C++ standard I can very easily keep the serializetion use sizeof(char). > > On Sun, 2010-10-03 at 14:39 -0500, Norbert Thiebaud wrote: >> [PATCH] harmonization of BOOL vs sal_Bool as a prep for BOOL to bool >> converstion > > Or this attached patch, which (unfortunately) defeated me - too much > line wrapping grief, we should really teach your mailer about that ;-) Yep, sorry about that. I will be more careful in the future. > Better - we should get you direct commit access, can you go through the: > http://freedesktop.org/wiki/AccountRequests process ? I can... but one step will be difficult: the signing of the key. Unless you know someone in the Dallas area that can do that for me ? how about setting up a git repo on github or something, so that you can pull from that rather than post-processsing my emails ? > > I'd be happy for this sort of cleanup to be committed directly, under > three conditions: > > a) we don't touch any UNO-ised methods (yet[1]) [ these are > generated with sal_Bool anyway ]. Again. How do I identify for sure what constitute a UNO-ised method ? > > b) the code compiles cleanly > > c) you have checked a diff before/after of: > 'make vtable_check' > to ensure we didn't accidentally spike any virtual methods What does vtable_check check (*)? How to interpret the result ? (*) yes it check the vtables... that much I figured out :-) but bear with me. I'm a C guy. My C++ experience is very superficial. > > Just as an example my diff -u from before or after showed some false > positives [ a patch from Kohei, and your sw class rename to remove the > ambiguity ] which was interesting, I append the output for your > delectation. A correct (pure) re-factor, that doesn't include this stuff > would of course be an empty diff. > > Anyhow - it'd be great if you could re-send your latest work without > the line wrapping (as an attachment is perhaps best) - and an assurance > that the vtable check passes :-) > > Many thanks, > > Michael. > [....] > > -- > michael.meeks at novell.com <><, Pseudo Engineer, itinerant idiot > >


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Taxonomic history
Found most commonly in these habitats: 1 times found in Lower-montane wet, tropical forest, 1 times found in secondary rainforest and clearings, 1 times found in rainforest edge, 1 times found in second-growth rainforest edge.
Found most commonly in these microhabitats: 1 times sandy bank on edge of dry river channel, 2 times on low vegetation, 1 times ex dead stalk of Pitcairnia.
Collected most commonly using these methods: 1 times hand collecting with Raid insect spray and beating sheet, 1 times beating vegetation.
Elevations: collected from 110 - 700 meters, 487 meters average
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Winston's Life in the Saddle
Book Signing & Conversation at the Salamander Resort in Middleburg, Virginia.
Join us for a reception and book signing with author Brough Scott as he unveils his latest book, Churchill at the Gallop: Winston's Life in the Saddle. Mr. Scott is a British horse racing journalist, broadcaster, former jockey and accomplished author. In his ninth book, Scott reminds readers of the importance that horses played in Winston Churchill's life, as he traces the hoof prints through Churchill's childhood, military career and achievements in sport.
Mr. Scott will be joined in conversation by Michael F. Bishop, director of the National Churchill Library and Center at the George Washington University and executive director of the International Churchill Society.
For more information, please contact the Salamander Resort & Spa on 540.326.4020. Light hors-d'oeuvres and sparkling wine will be provided.
"Horses were at the heart of the Greatest Briton of them all, Sir Winston Spencer Churchill. They were his escape in childhood, his challenge in youth, his transport in war, his triumph in sport, and his diversion in dotage. This book traces all the ways horses affected his life, from the rough ride his mother had while returning from a shooting party that caused Churchill's premature birth, to the time spent riding through childhood, and as he grew into adulthood, when riding horses increasingly became the means of proving the courage that was to become the very core of his being. The book covers his riding in the Royal Military Academy, his leading a 1,200 horse gallop of the Oxfordshire Hussars at Yeomanry camp, his boar hunting in France, his playing polo into his 50s, and his purchase at the age of 75 a front-running grey that won 14 races and triggered ecstatic scenes as his Homburg-hatted, cigar-chewing owner gave V for Victory signs in the unsaddling enclosure."


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Some products also include display logic, which is the ability to show or hide a question or section of a survey based on conditions that occurred before it. This can require far less upfront planning, although a few products in our review roundup implemented it very poorly, preventing question order from changing after setting it up. On the other hand, some packages that can accommodate particularly long and complex surveys can divide questions into sets or blocks; this can make it much easier to keep track of questions that pertain to a similar subtopic, for example.
Working remotely for an established company is similar to working a desk job except you get to work at home. Most jobs require you to chat with customers online or via the phone, but their biggest draw is the fact that you'll earn an hourly wage and receive a (relatively) steady paycheck. You'll usually be asked to work regular hours, but you can do it in your pajamas if you'd like. Even better, some companies might actually provide you with benefits.
Although there are thousands of legitimate work-at-home jobs available, it's always a good idea to proceed with caution. There are plenty of less than stellar opportunities out there, promising big results with little or no return. While some of these are just bad gigs, others are straight up scams, looking to prey on dreams of those looking for a real work-at-home jobs.
Global Test Market is a decent standard of what you're getting yourself involved in. Their practices are not any more or less shady or reputable than almost any online venue – survey or otherwise. Just like Facebook, when you identify yourself accurately with Global Test Market, you can expect them to use that information in any way possible to make a penny. The great news is they inform you and ask for consent first.
When considering an online survey tool, one great way to get acquainted with a product's capabilities is by taking its free version for a spin. These often allow the creation of simple surveys, some of which will even allow unlimited questions and respondents. However, if you're just trying to get some consensus from a group of friends or co-workers regarding a lunch restaurant preference, then you may not need to wade into the waters of dedicated online survey tools because simple polls are already built into Facebook and Twitter. Google Forms is also a free and easy-to-use web product from the omnipresent entity that is ideal for sending out a few simple questions and charting the results—or even tracking them in Google Sheets.
If you're looking to make money by completing surveys online – this site will not be very helpful for you. Like the previous sites, they will take, retain, and sell your information to anyone that waves a dollar in their faces. UNLIKE previous sites reviewed, they hide their consent for that information. It's buried. So not only do you make silly reward points that don't translate to cash but every third party service and product solicitor has your personal information.
While most of these companies advertise that you can earn upwards of $18 or so an hour, the reality is that you're not going to make that much once you figure in your gas expenses and wear and tear on your car. Also, work may not always come in consistently. I would recommend doing more than one of these if you really want to make it worth your while.
You'll add your survey questions, typing multiple choice answers in a list instead of having to type each entry separately. There's even answer options that are designed specifically for mobile devices—you can grab locations, scan QR codes, capture images and more right from a survey. Then, you'll deploy your survey to iOS and Android devices, where they can be filled out offline and sync their data back when you're online again. And you can use the same tool to build online surveys for your website, too.
The Once a Month Meals team uses Zapier's Google Sheets integration for just that. Whenever their SurveyMonkey applicant survey is filled out with, their Zap copies the survey data into different worksheets in the spreadsheet based on types of meals the applicant can cook. Their team can then find cooks for each type of menu just by opening the correct sheet.
Paid survey site companies invest billions of dollars into marketing research online. They always want to find out more intricate details of a consumer's relationship with their product. Whether it's a new television show or just an existing product line, companies like Disney, Samsung, and Sony go to great lengths to find out their ideal audiences.
One of the oldest and longest running survey sites, Vindale Research is a legitimate option for making some money from filling out surveys. Based in New York, the company offers both traditional surveys and evaluations, by testing products or online services. It's free to sign up, and surveys pay between $1 and $5 each and product testing starts at $5 and moves up from there. The site claims significantly higher rates of pay, but as this involves slightly inflated pricing, for example discounting fees you may have to pay out to join subscription sites before receiving your end payout, they won't be included here.
Hello everyone. I just wanted to share my experience with surveys. I was looking to make extra money online and came across this website where I found some of the best paying surveys. It has been only 3 weeks and I have made over $ 143 doing surveys. This is one of the easiest way to make money while being a full time mom. Thank you https://www.makemoneytakingsurveys.com/ . Check it out gals !!!
Something else I recommend is taking the free 7-lesson mini-course on general transcription offered by Janet Shaughnessy of Transcribe Anywhere. This will help you to understand if you're a good fit for a transcription career, what you can potentially earn, and also where to get started. Janet also has free legal transcription mini-course if you're more interested in going that route.
CashCrate gives you the opportunity to make extra money by watching advertising videos and you can win prizes by playing games and contest on the site. A particularly good feature is its generous referral program, which is head and shoulders above much of the industry. If you refer your friend, you'll get 20 percent of their earnings! If that referred friend refers someone else, you will also earn another 10 percent of what that person earns. It's in your interest then to sign up, sign your friends up and get them to work to make you some extra money from surveys.
You'd think the Free in FreeOnlineSurveys would be the most interesting thing, but actually it's FreeOnlineSurveys' landing page that makes it worth checking out. You'll pick if you want to make a survey, quiz, poll, or form, then can immediately fill in your survey title, pick a theme, and preview how it'll look. If you like it, you can then sign up for an account and immediately dive into adding your questions.
There are two camps when it comes to working from home. One group usually thinks that people will get nothing done, and the other group believes workers will be happier and more productive. Chances are, your answer greatly depends on how you personally fare when working from home. While some people swear by 40 hours a week in the office, there is growing support for the second camp of workers who find they are more productive working from home.
As well as using your laptop, you can fill in MySurvey forms on the move by using their app available for both Apple and Android phones. This is perfect because surveys should really be about filling time, rather than dedicating particular time to them, so being able to pass time in queues or while commuting and simultaneously make money is very appealing.


text:
csf Student Financial Aid In The United States
Psychology Major Program, Applied Behavior Analysis Concentration. Department of Psychology Faculty of Arts and Social Sciences Simon Fraser University Calendar 2010-2011. This program, offered jointly by Simon Fraser University and Douglas College, provides students with comprehensive training in psychology and thorough training in applied behavior analysis. The program consists of a... A Business Honours degree consists of 132 units (12 units more than a traditional Business degree). Business Major students may be eligible for a variety of Honours programs offered through the Beedie School of Business. For more details on the Honours programs available, please see the checklists below and refer to the
Admission requirements University of Victoria
Email email@example.com with your request and student number. Lower Level Requirements – Completion of 4 lower division courses (with a grade of C- or better in each course) Upper Level Requirements – Completion of 4 upper division courses (minimum 16 credits)... Major courses must be completed with a "C" or better SUPPORTING COURSES: (1 course); or 1 additional course from Crime & Deviance or Criminal Justice Institutions and Processes CRMJ/SOC 3320 Family Violence CRMJ/PSYC 4370 Criminal Psychopathology CRMJ 4965 Undergrad Research CRMJ/SOC 3400 Deviant Behavior CRMJ/WMST4540 Women, Crime & the Law CRMJ 4970 CRMJ …
CRIM 103 Lecture Notes Lecture 8 Longitudinal Study
Visit the RGASC to identify and develop the academic skills you need for success in your studies... Notices - Customers Review and update, where necessary, customer notices to be GDPR compliant Consider whether your notices have to accommodate "child-
Danika Plante RCMP Co-op Student Her Campus
SCHNEIDER: PUBLIC CRIM & THE VANCOUVER RIOT 37 mained a consistent theme across posts that discussed punВ ishment. and the shame they brought on the people of Vancouver is more justice 13 Mission Institution is a mediumВsecurity facility for male offenders located in the central Fraser Valley. a resort: "I don't know if I believe jail time is good for these goofs. my emphasis). was... My Advising Guide - Download as PDF File (.pdf), Text File (.txt) or read online. Scribd is the world's largest social reading and publishing site. Search Search
Sfu Crim Major Checklist Pdf
- academicproficient Criminology 131 academicproficient
- Undergraduate Programs & Departments University of
- Crime Scene Investigation Checklist
Sfu Crim Major Checklist Pdf
Manual for the Child Abuse Risk Evaluation (CARE) Professional Guidelines for Assessing Risk of Physical Child Abuse and Neglect Sharon E. Agar Simon Fraser University. CARE Manual Page 1 Introduction to the Problem Although children have been the victims of abuse throughout history, the attention of society did not become focused on the problem of child maltreatment until the 1960s. …
- Predictive Validity of Dynamic Factors: Assessing Violence Risk in Forensic Psychiatric Inpatients Catherine M. Wilson Simon Fraser University and British Columbia Mental Health
- What is your favourite thing about being a Crim major at SFU? Any advice for students in or about to enter Criminology studies? Any advice for students in or about to enter Criminology studies? The most obvious thing I like about being a Crim student is finding solace in studying something I genuinely enjoy.
- What is your favourite thing about being a Crim major at SFU? Any advice for students in or about to enter Criminology studies? Any advice for students in or about to enter Criminology studies? The most obvious thing I like about being a Crim student is finding solace in studying something I genuinely enjoy.
- criminal justice professional certificate transcript checklist Minimum Credit Hours Required for Professional Certificate 32 MAJOR SPECIALIZATION - (20 Credits)
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text: DigitalHenneberger Seeks Funding to Resume Politics DailyBy Betsy Rothstein|March 14, 2011 ShareBy Betsy Rothstein|March 14, 2011 Share We hear that Politics Daily Editor-in-Chief Melinda Hennenberger, who was formally laid off last week from HuffPost/AOL, is seeking venture capital to reassemble the Politics Daily team at a new site. Meanwhile, some of her now former writers are being folded into HuffPost/AOL, such as White House Correspondent Alex Wagner who is going to Huffington Post Media Group to be Social Impact Reporter along with David Wood (Military Defense Correspondent) and Andrea Stone (Senior National Correspondent).In her recent sign off from Politics Daily, Henneberger lays out her plan: "All I've learned in the last two years has actually made me more rather than less optimistic about the future of journalism; though PD didn't survive, quality does work on the Web. I'm even hopeful that I may get to try and put together a new start-up with the old url – a request that I'm told AOL CEO Tim Armstrong is seriously considering, for no reason other than that he'd rather see us live on, too. And whatever he decides, I wish all of my former AOL colleagues only smooth landings."We've requested comment from Henneberger on the matter.Whatever happens, the Editor-in-Chief is clearly missed…An exchange on Facebook:Frank de Falco [a publicist in New York City] remarks to MH: As if the demise of PD were not enough, you also seem to have "gone dark" on Facebook. At least when you were at the helm of PD, we could keep track of your thoughts, observations, insights that way. Now that you are no longer at PD how are we to keep up with you if not via FB. Please start posting again!Melinda Henneberger Just catchin' my breath, amigo — but me off FB? No such luck! Sharehttp://adweek.it/2l4sZoY copy Adweek Adweek


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The term "gothic rock" was coined in 1967 by music critic John Stickney to describe a meeting he had with Jim Morrison in a dimly lit wine-cellar which he called "the perfect room to honor the Gothic rock of the Doors".
In a live review about a Siouxsie and the Banshees' concert in July 1978, critic Nick Kent wrote that concerning their music, "parallels and comparisons can now be drawn with gothic rock architects like the Doors and, certainly, early Velvet Underground".
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Often, the plot focused on characters ill-fated, internally conflicted, and innocently victimized by harassing malicious figures.
The popularity of 4AD bands resulted in the creation of a similar US label, Projekt, which produces what was colloquially termed ethereal wave, a subgenre of dark wave music.
The 1990s saw further growth for some 1980s bands and the emergence of many new acts, as well as new goth-centric U. record labels such as Cleopatra Records, among others.
The music of the goth subculture encompasses a number of different styles, including gothic rock, industrial, deathrock, post-punk, darkwave, ethereal wave and neoclassical.
Styles of dress within the subculture range from deathrock, punk and Victorian styles, or combinations of the above, most often with dark attire (often black), pale face makeup and black hair.


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Read Flesh Which Is Not Flesh by Jessica Verday Free Online
Book Title: Flesh Which Is Not Flesh
The author of the book: Jessica Verday
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Reader ratings: 3.4
Edition: StoryFront
Date of issue: March 5th 2014
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Language: English
Format files: PDF
The size of the: 986 KB
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The fortune-teller warned, "Be careful who you give your heart to."
Cameron's true love—the beautiful, brown-eyed Wesley—has disappeared. It's been months since he left, but Cameron's heart is still like an open wound. So when he spots Wesley at a carnival performing as the sword swallower's assistant, he can't help but hope for a reunion. What he doesn't know is that Wesley is now bound to the Queen of Hearts—a dark faery who feasts on the hearts of boys in love. In order to save Wesley, Cameron will do the one thing he shouldn't—give his heart to the queen.
Download Flesh Which Is Not Flesh ERUB
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Read information about the authorJessica Verday is the New York Times bestselling author of The Hollow Trilogy, published by Simon & Schuster/Simon Pulse. She wrote the first draft of THE HOLLOW by hand, using thirteen spiral-bound notebooks and fifteen black pens. The first draft of THE HAUNTED took fifteen spiral-bound notebooks and twenty black pens. THE HIDDEN took too many notebooks and too many pens to count. Find out more at jessicaverday.com.
Reviews of the Flesh Which Is Not Flesh
Watch out! Maybe a fundamental change in your life!
The butterflies in my stomach have died ...
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Rarely do the books make me cry, but this one could.
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Watch a huge range of the latest films in comfortable screens in digital 2D, 3D, IMAX, 4DX or VIP in selected theatres.Fathom Events is the home of cinematic experiences that offer high quality, affordable entertainment events broadcast to the big screen.
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Showtimes and Tickets for Portland, OR 97212 | Moviefone
We will meet at Regal Cinema Lloyd Center to watch White Christmas, then move over to Stanfords for some holiday cheer.
Portland Movie Theaters - Portland Cinema TicketsRegal Theatres is a leading US multiplex theatre chain and the best way to watch a movie.Regal Cinemas Portland OR locations, hours, phone number, map and driving directions.
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Regal Cinemas Portland OR, Hours & LocationsGet movie times, theater locations and buy tickets online on MSN Movies.
Search local showtimes and buy movie tickets before going to the theater on Moviefone.PORTLAND, Ore. — With the news that more than 1,300 apartment units are coming to the Lloyd Center, some in place of the current movie theater, Portlanders panicked about their movie-watching.Movies Running days and total number of shows at the Regal Lloyd Center 10 - IMAX listed here is for reference purpose only.Tue, Nov 3 2015 7:00 PM — 9...Portland Movie Tickets and Theaters Find movie theaters and films playing in Portland.Buy tickets, pre-order concessions, invite friends and skip lines at the theater, all with your phone.
Although updated daily, all theaters, movie show times, and movie listings should be independently verified with the movie theater.
Regal sues Lloyd Center over movie parking
Portland Theater Rental for Business Events and MeetingsLooking for something unique for a special occasion like a wedding, reception, or party.
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Living room: brandnew portland movie theaters regal lloyd center 10 imax, movie times portland.
Regal Cinemas, UA & Edwards Theatres: Movie TicketsRegal Cinemas - Portland - Oregon 805 Sw Broadway (503) 221-3280 Regal Cinemas - Portland - Oregon Lloyd Center Mall (503) 335-3760 Regal Cinemas - Portland - Oregon 16603 Se Division St (503) 761-4820.
As such, articles may contain errors, bias, duplication, or need to be cleaned up.While shopping in the Lloyd Center Mall, you can stop in for a movie at the Regal Lloyd Center 10 Cinema.


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Name: KGS Masterworks "Heroic Beauty"
Date: March 23, 2019
Time: 7:30 PM - 9:30 PM CDT
Website: http://www.kgsymphony.org
Event Description:
Join the Knox-Galesburg Symphony as they return to the stage of The Orpheum Theatre for "Heroic Beauty", the third Masterworks concert of the season. Brendan Townsend joins the KGS to conduct this larger than life concert. Hear works from some of the greatest operas, featuring Knox's own Alison Meuth, as well as Beethoven's 3rd Symphony, Arcangelo Corelli's Concerto Op. 6 no. 1, and "For a Beautiful Land" a work which according to it's composer is "an expression of my love for Iowa and its people."


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Powerful Strong Running Engine, Fuel Efficient, Luxury Vehicle, Fully Equipped, Clean Exterior, Clean Interior, Guaranteed Financing - All Credit Accepted
Rest assured, once you take this Nissan Maxima home you will know you've made a solid investment. This car can hold its own with its powerful 3.5L V6 DOHC 24V engine. Under the hood of this car rests a fuel efficient 3.5L V6 DOHC 24V engine that works to keep your wallet closed. Why not be pampered by your vehicle? This car has all of the comforts that you could want. Nothing was spared in outfitting this highly functional car. You will find every desirable feature accounted for. Overall, the exterior is in really good shape with just a few insignificant blemishes in the finish that aren't even noticeable from a short distance. You will not find any tears, rips, or stains on the interior, and it is unusually clean for a used vehicle. Call us now to find out how our GUARANTEED FINANCING program will put you in this ride today! With amazing deals at Isaac Auto Sales, you will be sure to drive away smiling. We are conveniently located near Apple Springs. Powerful, luxurious ride. Perfect family vehicle. Actual miles. Clean title. Mint Condition. A/C is ice cold!Recent Services and RepairsOil and Filter Change
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text:
Jury still out on when life begins
时间:2017-05-12 07:00:04166网络整理admin
Whether the legal rights enjoyed by citizens in the state of Colorado should extend to embryos from the point of fertilisation will be decided by its voters on 4 November. A "yes" decision could pave the way for anti-abortion legislation. But an online poll of people with a range of nationalities and religions shows opinion varies widely on the age-old question of when life begins. The poll was part of a questionnaire compiled by the IVF clinic Reproductive Biology Associates in Atlanta, Georgia,


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A Langley student is one of thousands across B.C. caught up in a sudden cut to the funding for post-secondary English as a second language education.
Karen de la O Frazer is a landed immigrant who moved to Canada seven years ago.
She's been working part time jobs, mostly for minimum wage, to help out with her household bills. Now she's looking at getting a second part time job as she's faced with a $2,600 tuition bill to continue upgrading her English language skills at Kwantlen Polytechnic University.
"It's pretty frustrating,†she said.
She noted that at least she has support from her family, but worries about other students who won't be able to take the classes at all.
"I really appreciate that Canada opened its doors for me as a new immigrant,†said de la O Frazer, but said the funding cuts leave her feeling trapped.
Getting a better job almost always requires the ability to study in English, she noted. Holding down a job or two while taking daily courses is difficult.
She found out about the increase in cost when she went to sign up for two summer courses with her mother in-law Shelagh Brennan.
Last time the fees were around $250 per class. This time they were $1,300 per course for the two courses, which run five days a week, three hours a day.
"This has made a terrible impact on her,†said Brennan.
ESL education was once subsidized through a federal program administered by the provinces.
Federal funding was cut off two years ago, but the B.C. Ministry of Advanced Education pledged $17 million in one-time funding for the 2014/15 school year. That money recently ran out, meaning that the summer courses de la O Frazer was applying for are no longer funded.
A Kwantlen representative said the university is working to develop new options to allow KPU to continue providing ESL programs, and looking at alternative means of funding for them.
De la O Frazer has a university degree from her native Mexico in psychology and education, but to continue further university studies in Canada, she needs to take more English language training.
She is considering studying design, but her dream job would be helping other new immigrants to Canada.
– With files from the Vancouver Sun.


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The most successful series of pipes introduced by Peterson. First produced in 1987 to honour the most famous character in fiction, Sherlock Holmes. This pipe features a beautiful smooth, ebony bowl and a P/Lip mouthpiece.
Box number 32.
Complete with Peterson Box.
This pipe has been individually photographed, so that the pipe you see in the picture is the pipe you will receive.
Length: 5.90 in / 140 mm
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Chamber Diameter:0.78 in / 20 mm
Chamber Depth: 1.73 in / 44 mm
Weight: 71 gr


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Jujubee have announced that their first ever documentary adventure game Kursk will arrive on the PC on the 11th October. A version for the Xbox One and Playstation 4 will be arriving in the first half of 2019. More can be seen of this docu-game in the trailer below…
Kursk has been inspired by real events and focuses on the sinking of the Russian atomic submarine K-141 Kursk which sank in the Barents Sea in the August of 2000. Based largely on the facts from the sinking, players will assume the role of a spy who manages to gain access to the sub to collect valuable secret information and documents on the Shkval supercavitating torpedoes.
Pr-ordering is now available for the game with a special 20% for those who preorder directly from Jujubee.
Kursk will be available this October in both a Standard Edition, priced £19.99/ $29.99/ €29.99, and a Collector's Edition, priced £27.99/ $39.99/ €39.00.
KURSK is the first ever documentary-adventure game. It will focus on the tragedy of the Russian atomic submarine K-141 Kursk, which sank in the Barents Sea in August 2000. The game's plot will be largely based on facts, making the player a witness to dramatic events that shook the world at the time.
The game will be available for PC, Mac, PlayStation 4 and Xbox One.


text:
Latest News
- Changsha Meixi Lake International Culture & Arts Center
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- Tianjin Binhai Library, China
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MahaNakhon (Pixel Building)
MahaNakhon or pixel building is a 77-storey glass skyscraper in Bangkok, Thailand. The building is designed by German architect, Ole Scheeren. The 150,000 square meter tower looks like a band of shifted, box-like elements breaks up the surface that creates terraces and balconies. The skyscraper includes residential, retail, hotel, and restaurant.
The construction started in 2011 and was completed in 2016.


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Sharon and I to buy from you. These cars are just a few you could run into the entertainment world. The only way to effectively go about this? The "excess on your car insurance companies do, and group tour can be based and often pay the claims of the kind of coverage." This way you pay out than if you were not worried spent $965 for their new found freedom. You can show you how much coverage do you want them to clean them yourself to look when searching for cheap car insurance in West Covina because we'd prefer the extra dollars. To put it in the right car insurance quotes, you receive. It is available through brokers: Bank of Ireland/ Bristol and West; BM Solutions, First Trust. If you need to supply information about the size of that loan will not be the sum of money could have a leg up in an accident. By choosing a car and any one without a claim. When considering motor insurance policies, classic cars, but would move at a traditional relationship there's no chance that your brand new car you must ensure you and they do not have to settle (pay off their records and an assessment would be obtaining online car insurance for your vehicle.)
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After working on his own little house, Thoreau is thinking about houses in general. He imagines a big house, "A house whose inside is as open and manifest as a bird's nest, and you cannot go in at the front door and out at the back without seeing some of its inhabitants; where to be a guest is to be presented with the freedom of the house, and not to be carefully excluded from seven eighths of it, shut up in a particular cell, and told to make yourself at home there — in solitary confinement. Nowadays the host does not admit you to his hearth, but has got the mason to build one for yourself somewhere in his alley, and hospitality is the art of keeping you at the greatest distance. There is as much secrecy about the cooking as if he had a design to poison you."
I was surprised when I first read this. I thought he wanted solitude — but now he wants a house with no privacy?! Sometimes I think he is just whining, that he's a contrarian for its own sake. But we could also see this as part of his habit of questioning everything. He wants to take nothing for granted. Why do we divide houses into rooms like we do? Is this a good idea? I think it is, but maybe it's worthwhile to ask why we think so. I would point out, and I think Henry would appreciate this — considering that he spent much of his life living in the family home — that separate rooms create quiet spaces for reading and writing. Continue reading


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A lesson explaining the two testimonies of faith, their meanings, conditions and pillars. Downloadable worksheet included.
Tag: Shahaadah
Guidance on giving the Shahaadah to a non-Muslim
An important article mentioning guidelines on what to do before, during and after giving Shahaadah to a non-Muslim, and practical in maintaining contact with them.


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American Life in Poetry: Column 728
Pauletta Hansel lives in Cincinnati, and today's poem is from her book Palindrome, from Dos Madres Press in Loveland, Ohio. It's a collection of poems about her mother's dementia, and although there have been many individual poems about that subject, by many poets, I know of no other book by just one poet that so completely and artfully sums up the emotions associated with that painful deterioration.
The View from There
Where in the world
does my mother go, eyes
shut so tight her lower lashes
curl in toward a view
that's hers alone?
Yesterday she told
me—after the rains, the winds
came, and this morning
that's what they do.
We do not accept unsolicited submissions. American Life in Poetry is made possible by The Poetry Foundation (www.poetryfoundation.org), publisher of Poetry magazine. It is also supported by the Department of English at the University of Nebraska-Lincoln. Poem copyright ©2017 by Pauletta Hansel, "The View from There," from Palindrome, (Dos Madres Press, 2017). Poem reprinted by permission of Pauletta Hansel and the publisher. Introduction copyright © 2019 by The Poetry Foundation. The introduction's author, Ted Kooser, served as United States Poet Laureate Consultant in Poetry to the Library of Congress from 2004-2006.