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Posted by Steve Almond on May 15, 2019
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Installing a tachometer on your Vehicles can assist in preventing critical repair problems, however. You might have a weak ground issue. The way the brain learns is a subject that still requires a good deal of study. How it learns can be associated by how it is able to create memories.
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StartHub Demo-Night
March 7 @ 16:30 - 20:00
Hereby we would like to invite you to our StartHub Demo-Night on the 7th of March from 16.30 until 20.00. Let's together take a look at what happened this previous half year and look towards the future of StartHub. During this evening we will celebrate new collaborations, the success of our new programme and showcase the progress of our student start-ups. You can visit throughout the evening, where you see what our student entrepreneurs have been doing, speak with our partners and campus colleagues while enjoying a drink. At 18:30 the highlight of the evening is a pitching contest for young, upcoming entrepreneurial talent. Afterwards we facilitate matchmaking and networking activities.

subset: commoncrawl


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To the Earl of Carryck
My Lord,
Allow me to report success: at long last I have located the man I believe to be your cousin. He is known as Dan'l Bonner, called Hawkeye by his associates, Indian and White. Even if there were not plentiful documentary evidence that he is your uncle Jamie Scott's son by Margaret Montgomerie, the sight of him alone would convince anyone that he is indeed a Scott of Carryck.
Bonner resides on the northernmost frontier of the State of New-York, where he was raised--as you always believed--by ationatives. I trust you will be pleased to learn that he took as guidwife a Scotswoman (now deceased), whose father was, by fortunate circumstance, a Munro cadet of Foulis. She bore a son, called Nathaniel, now some thirty-six years of age, in robust health andwitha new guidwife in hopeful expectation. Both father and son have made their living as hunters and trappers in the wilderness that the Natives call the endless forests, between this place and the Mohawk Valley. That is where I found Nathaniel, who then directed me here to Montréal. He is a likely young man, and I believe you will be well pleased with him.
Before I can carry out the task entrusted to me and convey Bonner and his son home to Carryck, Dan'l must first be disengaged from the military garrison where he is currently being held for questioning, in the matter of a large shipment of the King's gold, missing for some forty years.
You see that the family resemblance is more than simple physiognomy.
I have had word from Pickering, who has docked the Isis at Halifax, but first getting to Bonner is a very complicated undertaking, and one which may require some drastic steps. The whole venture is made even more complex by the interference of the Lieutenant Governor, Lord Bainbridge. My Lord will remember Pink George from the unfortunate incident with the pig, I trust. He, at any rate, has not forgot it.
Yours at command, My Lord
Angus Moncrieff
Montréal, this third day of January,
To Mr. Nathaniel Bonner
Paradise, on the West Branch of the Sacandaga
State of New-York
With the prodigious help of Rab MacLachlan and your excellent directions, I have found your father. Unfortunately, the Lieutenant Governor had found him first and he paces a cell in the garrison gaol while being questioned on a matter referred to only as the "Tory gold," details of which MacLachlan scruples to share with me. While I have seen your father for only a moment I can report that he seems to be in good health. A message in two parts:
First, a young man called Otter, of the Mohawk (or Kahnyen'kehâka as I understand they call themselves), was arrested with him, but is unharmed. Second, your father believes that a "visit to the pomkin patch" is the only way to resolve his current difficulties.
If, as I suspect, this means that you will be coming to Montréal, I beg you to call on me in my rooms in the rue St. Gabriel. You will find me to be an experienced and willing assistant in the garden. I ask only for your father's ear for an hour to present my lordship's case.
I believe your lady's time must be close at hand. Please allow me to send my very best wishes for her safe delivery, and for the continuing health of your entire family.
Your Willing Servant
Angus Moncrieff
Secretary and Factor to the Earl of Carryck
Montréal, this third day of January, 1794
North to Canada
1 February, 1794
On the edge of the New-York wilderness
In the middle of a blizzard in the second half of the hardest, snowiest winter anyone in Paradise could remember, Elizabeth Middleton Bonner, sweat soaked, naked, and adrift in burning pain, wondered if she might just die of the heat.
Once again she grabbed the leather straps tied to the bed frame to haul herself forward, and bore down with all her considerable strength.
"Come, little one," sang the girl who crouched, waiting, at the foot of the bed. Her ten-year-old face was alight with excitement and fierce concentration, her bloodied hands outstretched, beckoning.
From a basket before the warmth of the hearth came the high, keen wail of Elizabeth's firstborn: a daughter, just twenty minutes old.
"Come, child," crooned Hannah. "We are waiting for you."
We are all waiting for you.
In the grip of a contraction that threatened to set her on fire, Elizabeth bore down again and was rewarded with the blessed sight of a crowning head. With shaking fingers she touched the slick, wet curls and her own flesh, stretched drumtight: her body on the brink of splitting itself in two.
One last time, one last time, one last time. She strained, feeling the child flex and turn, feeling its will, as strong as her own. Elizabeth blinked the sweat from her eyes and looked up to find Hannah's gaze fixed on her.
"Let him come," the girl said in Kahnyen'kehâka. "It is his time."
Elizabeth pushed. In a rush of fluid her son, blue-white and already howling, slid out into her stepdaughter's waiting hands. With a groan of relief and thanksgiving, Elizabeth collapsed backward.
For one sweet moment, the wailing of the newborns was louder than the scream of the blizzard rampaging through the endless forests. Their father was out there, trying to make his way home to them. With her arms crossed over the warm, squirming bundles Hannah laid against her skin, Elizabeth muttered a prayer for Nathaniel Bonner's safe delivery from the storm.
As Elizabeth labored, the small handful of farmers and trappers with the good sense to be stranded by the blizzard in Paradise's only tavern sat huddled over cards and ale, waiting out the weather. While the winds worked the rafters like starving wolves at a carcass, they told stories in easy, slurred voices, but they watched their cards and tankards and the long, straight back of the man who stood, motionless, at the window.


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Shoe Storage Benches With Doors – Are you really running out of space on your room? Have you got more blankets than fit on your linen closet? Are your children having trouble maintaining their space arranged? Are you looking for a reading bench for your bedroom and might really use a bit more space for storing things? It's a storage chair for the bedroom. Other individuals might not understand the value in getting a bench in their bedroom. There are lots of reasons to integrate this superb piece of furniture in your room today.
Storage chairs come in all shapes and sizes. These pieces of furniture are wonderful ways to store things which aren't needed all of the time like linens and blankets. They can also be used to hold shoes or other articles of clothing that are worn only during specific seasons.
The first is what size do you want. How big is your room? The right size bench will flow perfectly with its surroundings. A bench that is too small will look odd and out of place. One that is too big will become a barrier to get around and make your space look small also. When contemplating size measure your distance look at options and see what will fit the best with a piece of cardboard or other substance to mimic the bench. If your bench is going in front of a window be sure you will like the elevation also.
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The Aurora Public Schools is committed to the policy that all persons shall have equal access to its programs, facilities, and employment and does not discriminate on the basis of race, age, color, creed, national origin, sexual orientation (which includes transgender), conditions related to pregnancy or childbirth, disability, religion, ancestry, sex or need for special education services, or genetic information for employment and provides equal access to the Boy Scouts and other designated youth groups. Career and technical education opportunities will be offered without regard to these protected classes. In adhering to this policy, the Aurora Public Schools abides by Title IX of the Education Amendments of 1972, the Americans with Disabilities Act, Section 504 of the Rehabilitation Act of 1973, the Age Discrimination Act and Titles VI and VII of the Civil Rights Act of 1964.
I have loved working with kids since I was 12, shadowing a family friend in her in-home daycare, until I began working there at 14. I grew up in that environment starting at age 9 however, so I was always familiar to the process, if not involved. She took children from 3 mo to 6 yrs, and from there I worked at a summer camp with kids age 5 to 11, where I also coordinated birthday parties based on the parents' requests. Meanwhile working with various clients throughout the years. I recently worked in a center as an Infant Supervisor, but I prefer 1 on 1 with families so I went back to nannying! I've just had a little one of my own at the end of July, and took a little time off for baby, but I'll be back to work at the end of October. When I am ready I would prefer a full time family that is okay with him coming along with me. If this will work for you, please get back to me! I will look forward to meeting you in the future!
We recognize that there are good reasons to make changes in early childhood education and care (ECEC) in Ontario. But we believe that these must be based on the best available evidence about what is of most benefit to children and families; we argue that these proposed changes are not. Additionally, we suggest that changes in ECEC in Ontario will continue to have negative effects if they continue to be "piecemeal".
Disclaimer: We at ChildcareCenter strive daily to keep our listings accurate and up-to-date, and to provide top-level, practical information that you can use and trust. However, ChildcareCenter.us does not endorse or recommend any of the childcare providers listed on its site, cannot be held responsible or liable in any way for your dealings with them, and does not guarantee the accuracy of listings on its site. We provide this site as a directory to assist you in locating childcare providers in your area. We do not own or operate any child care facility, and make no representation of any of the listings contained within ChildcareCenter.us.


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By Edited by Brahim Attaf
Read Online or Download Advances in Composite Materials for Medicine and Nanotechnology PDF
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This booklet experiences the most recent advances within the improvement of silicon nano-biotechnology for organic and biomedical purposes, which come with biosensing, bioimaging, and melanoma remedy. during this ebook, newly built silicon nano-biotechnology and its biomedical purposes are systematically brought.
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Sample text
Biomaterials 25(24):5481-5489. , Shinomiya, K. and Tanaka, J. 2007. Fabrication of three-dimensional porous hydroxyapatite/collagen composite with rubber-like elasticity. Journal of Biomaterial Science, Polymer Edition 18(4):393-409. , Shinomiya, K. and Tanaka, J. 2006. Control of pore structure and mechanical property in hydroxyapatite/collagen composite using unidirectional ice growth. Materials Letters 60(8):999-1002. Zhang, J. and Misra, R. D. K. 2007. Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: Core-shell nanoparticle carrier and drug release response.
28 Advances in Composite Materials for Medicine and Nanotechnology The shape of the mineral phase of the composite material obtained by in vitro coprecipitation in the presence of fluoride is biomimetic and similar to the mineral phase of natural bone. The main difference between the mineral phases of bone and composite materials obtained in the presence of F- is the size of the crystal. In order to obtain naturalsized crystals in the mineral phase, crystallization inhibitors may be used. Under these conditions, we expect to reduce the size of the crystals.
HA, the mineral that occurs naturally in bone tissue, has also been used extensively as a tissue engineering scaffold material due to its 38 Advances in Composite Materials for Medicine and Nanotechnology osteoinductivity. It is typically used for coating biomedical implants to induce bone regeneration, allowing the implant to integrate with the surrounding tissue. While HA was originally popular for use as a scaffold for tissue engineering, it is non-resorbable in bulk form which has limited its popularity as a bone graft substitute material (Figure 3).
Advances in Composite Materials for Medicine and Nanotechnology by Edited by Brahim Attaf
by William


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The Forum > General Discussion > The UN has to go!
The UN has to go!
SteeleRedux Quote "but instead charged on to the next diversion." Pointing out others have woken up to a lot just being economic refugees or economic migrants same thing is not a diversion it is more evidence as to the reality of what is occurring around the world.
There are legitimate refugees but they are in camps next to the country they left as per the refugee convention.
I am not going to answer questions that you know are correct but are being pedantic in wanting examples, how long have infowars been around if every story was fake they would be gone long ago.
Posted by Philip S, Thursday, 6 December 2018 9:29:35 PM
Hi SteeleRedux,
I had to dig around a bit to find a link to the podcast episode on the webpage you linked to, were you trying to simply use the word 'Pizzagate' to try to discredit me or did you actually watch the podcast episode?
I think the #Pizzagate tag had more to do with the 'Focus on the Facts' radio show and Evelyn Pringle who interviewed George Webb as a guest rather than George himself advertising Pizzagate.
I listened to that episode and there was no mention of Pizzagate.
However he'd been a guest 1 month prior and did discuss it, but I haven't listened to that episode.
I think there was some legitimate questions over Pizzagate, but I stayed away from Comet Pizza saga because there was no upside to it.
I didn't like the smell of it, and that was even before someone ran in waving a gun, and the whole thing turned into a farce.
My interest was more towards Laura Silsby and the contents of Podesta emails rather than Comet Pizza.
I thought the pedophile related logos there were curious however.
George's research looked at pedophilia more in the area of compromise operations, where people would be filmed in the act and then become controlled by others once they hold it over them. High profile people could be taken on expensive yachts out into international waters or those who rode the Lolita Express out to Jeffrey Epstein island where they thought they were safe from scrutiny, for example.
And he didn't go looking for the story, it was a legitimate line of questioning in regards to his investigation into Clinton operations in Haiti as well as in regards to the Podesta emails release.
Posted by Armchair Critic, Friday, 7 December 2018 11:03:42 AM
I'll stick up for Infowars, though I haven't watched it much lately.
Alex Jones documentaries were what first woke me up, but he often rants too much on his show and doesn't spend enough time explaining facts, so it really does become a 'War for your mind' (Infowars slogan) as much as it is a news or information service.
Also he won't criticise Israel as much as Israel sometimes deserve the criticism.
Over the years I've moved across to other shows which provide a better analysis of the kind of topics Alex discusses, but I'll still stick up for them. They're a bit 'alarmist' but certainly no worse in factual content then other mainsteam media news, when you factor in fake news narratives.
Posted by Armchair Critic, Friday, 7 December 2018 11:17:56 AM
Dear AC,
Well actually I was discrediting Webb and rightly labelled him a kook. He is antivaxx, doesn't believe HIV causes Aids, and went to hospital with 6 others after consuming his own alternative medicines. Grade A kook.
You wrote; "I think there was some legitimate questions over Pizzagate". There are no legitimate questions over Pizzagate. Nothing happened. It was all made up. I get that you love a good conspiracy but most have some semblance of substance. This had none. Zip, Zilch, Zero and those who think otherwise are also kooks.
Posted by SteeleRedux, Friday, 7 December 2018 11:58:51 AM
Well you know at some level I should be proud to be called a kook, and wear it like a badge of honour;
In the same way that I'm a racist, a homophobe, a rapist, a bigot, xenophobe, misogynist, anti-semite etc.
- Apparently...
Being a kook really just means I don't naively believe what I'm told without putting the issue to some scrutiny first.
"He is antivaxx, doesn't believe HIV causes Aids, and went to hospital with 6 others after consuming his own alternative medicines. Grade A kook."
Well I don't know if these things you allege are true, and I've been watching him for 2 years +
- Do you have any link to him stating this as fact?
Antivaxx is a vague term - why do you seem to use all these vague terms as poor attempts to discredit me?
Using all these terms just mischaracterises the actual issues for the benefit of convincing other useful idiots.
I might be considered an antivaxxer too, (add it to the above list) because I don't tow the official stance to the T, and I question the safety and effectiveness of some vaccines, whether they're safe for kids under certain ages, and whether it's safe for them to be given so many shots at once, and whether the vaccines themselves are truly safe (given side effects and allergies) and if they aren't 100% safe that parents should be informed of the risks and hold the final decision over what is given to their child.
- This doesn't necessarily mean I'm against the science of inoculation despite the intention to label one as such.
That doesn't make me a kook, it makes me cautious, diligent and responsible.
At some point, I'll go have a look at the Pizzagate stuff, try to refresh myself with the legitimate aspects to it (the parts that held merit and the parts that didn't) and I'll come back to it.
Posted by Armchair Critic, Friday, 7 December 2018 2:46:15 PM
Dear AC,
I neither want to discourage nor disparage your desire to be comfortable with the term kook. However this is the second time that you have used my critique of someone else to impugn that I was disparaging you directly. I was not.
May I gently suggest that for you to be thinking otherwise does flag a paranoia that seems often in the mix among those who enjoy the fruits of conspiracy theories.
Posted by SteeleRedux, Friday, 7 December 2018 3:55:38 PM


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DSAGM, The Danish Society of Pattern Recognition and Image Analysis (The Danish chapter of IAPR) holds its 17th National Meeting.
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The DSAGM general assembly will take place Monday August 17, 2009 at 16:00-17 at the Backafallsbyn conference facilities.


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I've been following the whole mess that is the Shirley Sherrod resignation/firing over her NAACP speech, and there's definitely a post in there about the importance of context and good will. Needless to say, it's been entertaining to watch the coverage of the story on various news networks.
Last night, apparently Bill O'Reilly took a shot at Rachel, and I LOVE LOVE her response to him — check it out:
When you got all 'kick your network's butt' and 'madam' on me, you weren't really trying to tout your network's ratings. You were trying to take the attention off of me saying that your network, Fox News, continually crusades on flagrantly bogus stories designed to make white Americans fear black Americans, which Fox News most certainly does for a political purpose, even if it upends the lives of individuals like Shirley Sherrod, even as it frays the fabric of the nation, and even as it makes the American dream more of a dream and less of a promise… but even if no one watches us at all, except for my mom and my girlfriend and people who forgot to turn off the TV after Keith, you are still wrong on what really matters, and that would be the facts, Your Highness.
So dad, if you're reading this post, this week illustrates for you why I don't trust Fox News. Any "news" organization that has such a hateful ideology isn't worth my remote click.


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Blockade of CD49d-mediated lymphocyte trafficking has been used therapeutically for certain autoimmune diseases, such as multiple sclerosis (MS). In addition to negative effects on the trafficking of mature lymphocytes to sites of inflammation, CD49d blockade in mice and monkeys rapidly mobilizes hematopoietic stem/progenitor cells (HSPCs) capable of short- and long-term engraftment. Here we aimed to ascertain the effects of treatment with antifunctional anti-CD49d antibody in humans (MS patients receiving infusions of the CD49d-blocking antibody natalizumab) on levels of circulating HSPCs after a single dose of antibody or after long-term treatment. On average, 6-fold elevated levels of circulating CD34+ cells and colony-forming unit-culture (CFU-C) were achieved within 1 day of the first dose of natalizumab, and similar levels were continuously maintained under monthly natalizumab infusions. The blood of natalizumab-treated subjects also contained SCID-repopulating cells. The fate of these circulating HSPCs and their clinical relevance for MS patients remains to be determined.
In nonhuman primates, CD49d-blockade with humanized antifunctional antibodies results in rapid (peak < 1 day) and prolonged (> 10 days) increase in circulating hematopoietic stem/progenitor cells (HSPCs).1,2 Elevated circulating HSPCs were likewise observed in anti-CD49d antibody-treated mice.2 Furthermore, mice conditionally ablated for CD49d sustain more than 8-fold elevated levels of circulating HSPCs without evidence of progressive accumulation or of bone marrow (BM) depletion for their life span.3 Even though the homing efficiency of anti-CD49d-mobilized HSPC was reduced, if sufficient numbers of cells were used, these cells provided short- and long-term engraftment. Studies in humans treated with anti-CD49d antibody, particularly after protracted blockade of CD49d, have not been reported, nor have any other studies of prolonged administration of mobilizing agents been performed. A clinical-grade humanized mouse-antihuman function-blocking CD49d antibody (natalizumab, Tysabri;Biogen/Idec, Cambridge, MA) is available under a special restricted distribution program for treatment of relapsing-remitting multiple sclerosis (MS) patients who failed to respond to or did not tolerate first-line therapeutics.4 As trials of natalizumab in healthy volunteers are not justifiable, because of prolonged immune-modulating effects of the antibody, including the possibility of rare, but potentially fatal progressive multifocal leukencephalopathy,5 we made observations in a cohort of MS patients receiving/scheduled to receive disease-modifying monotherapy with natalizumab.
Human subjects and protocol
Adults with MS receiving/scheduled to receive disease-modifying therapy with natalizumab (300 mg intravenously once every month) at the University of Washington Departments of Neurology/Rehabilitation Medicine were eligible for participation. Exclusion criteria were other disease-modifying therapy, steroids, or lithium. After written informed consent was obtained in accordance with the Declaration of Helsinki, immediately preceding the next scheduled natalizumab infusion blood was drawn from "untreated" patients (before the first infusion) and "chronic" patients (≥ 5 prior doses). In some patients, a second blood draw was done after infusion, generally on the subsequent day. A cohort of healthy controls was also recruited. Blood draws were anonymous; except for classification as "untreated/first-dose" or "chronic" recipient, no subject information was collected. The study was approved by the University of Washington Internal Review Board.
HSPC assays
Colony-forming unit-culture (CFU-C) assays were performed as described.6 Side-scatter low/CD34bright (CD34+) cells were quantified by flow cytometry, as described.7 The presence of competitive repopulating units (CRU) was tested in xenotransplants 9 to 10 weeks posttransplantation, as described. Transwell migration of CFU-C toward SDF-1 (100 ng/mL) was enumerated as described.6 Cell-cycle status on flow-sorted CD34+ cells was analyzed by Acridine Orange staining.8
Results and discussion
Before the first natalizumab dose, circulating CD34+ cells and CFU-C in "untreated" MS patients (Figure 1A,D) were within the range reported for healthy subjects9 and our healthy controls studied concurrently (ie, MS per se is not associated with elevated circulating HSPCs). Subjects on "chronic" natalizumab treatment had 5- to 7-fold elevated circulating CD34+ cells and CFU-C (Figure 1A,D) 1 month after infusion. In a subgroup of "chronic" subjects, circulating HSPCs were analyzed before and 1 day after the monthly dose of natalizumab. Renewed infusion did not result in significant further augmentation of circulating CD34+ cells or CFU-C (analyzed 1 day after the infusion, Figure 1C,F), indicating continuous functional satiation of CD49d on BM-HSPC with standard natalizumab dosing.
Comparison of natalizumab-recipients before and 1 day after the first infusion ("1st dose") revealed 5- to 6-fold increased CD34+ cells and CFU-C after the first infusion (Figure 1B,E). Mean postinfusion values after the first dose were no different from those in "chronic" natalizumab-recipients before or after repeated natalizumab infusions, documenting achievement of maximal levels of circulating HSPCs within 24 hours of a single natalizumab infusion. Because circulating CD34+ cells and CFU-C in untreated MS patients were normal, the increased frequency of circulating HSPCs in natalizumab-treated MS patients is apparently the result of drug effects.
CD34+ counts in natalizumab-treated MS patients were thus approximately one-sixth of those in MS patients mobilized with granulocyte colony-stimulating factor (G-CSF).10 However, the relative frequency of clonogenic cells appeared to be higher among natalizumab-mobilized than among G-CSF-mobilized CD34+ cells (1 in 3 CD34+ cells for natalizumab vs 1 in 10 for G-CSF mobilized CD34+ cells),11 likely because the G-CSF induced proliferation/differentiation dilutes clonogenic cells with more mature CD34+ subsets. Thus, the difference in HSPC mobilization potency may be less pronounced than CD34+ numbers suggest. CD34+ counts in natalizumab patients were one-third of those achieved with the CXCR4-antagonist AMD3100 in healthy volunteers.9
The sustained HSPC levels in natalizumab recipients contrast with mobilization kinetics after G-CSF, in which after the peak on day 5, circulating HSPCs numbers are regressive despite continued administration.12,13 It indicates that, without CD49d-mediated BM retention, a new equilibrium is established between HSPCs in BM and those in circulation. In natalizumab recipients, a total of approximately 50 × 10E6 CD34+ cells (8 CD34+ cells/μL × 6 L of blood) are in circulation at any given time. Assuming that the transit time of normal circulating HSPCs is short14 and not very different from normal in natalizumab-treated patients (supported by unpublished data for CD49d−/− mice), several million CD34+ cells are trafficking through the blood of the average natalizumab recipient every day. A similar pattern of sustained elevation of circulating HSPCs was observed in CD49d-deficient mice.3
Most CD34+ cells in blood from natalizumab patients are quiescent (Figure 1H), a phenotype associated with favorable homing and/or engraftment.15,16 Similar data were reported for unmobilized17 or G-CSF-mobilized CD34+ cells18 (ie, may represent a general feature of circulating HSPCs). Peripheral blood CFU-C from natalizumab-treated patients did not migrate in in vitro transwell assays, whether spontaneously or SDF-1–directed, in contrast to normal BM HSPC (Figure 1G). We attribute the lack of migration to continuous saturation by natalizumab, as several previous observations show absence of migration with anti-CD49d antibody-treated cells.
To establish whether peripheral blood of natalizumab-treated patients contained any CRU, xenotransplants of mononuclear cells from 7 to 8 mL of blood (containing 50 000-60 000 CD34+ cells) were performed. Human engraftment of more than 1% was observed in 3 of 3 recipients (not shown), although no quantitative conclusions about CRU can be drawn from these studies. The engraftment data are of interest in view of the cells' inability to migrate in vitro. Similar to our data, cells mobilized with the chemokine Groβ did not migrate in vitro but engrafted well,19 reinforcing the view that in vitro behavior of HSPCs cannot predict their in vivo performance.
The role, or clinical consequence, of elevated circulating HSPCs for natalizumab-treated MS patients is unclear. Potential effects of HSPC on remodeling/repair of nonhematopoietic organs have been reported.20,21 It is thus tempting to hypothesize that circulating HSPCs may contribute to the anecdotal cases of neurologic improvement under therapy, which may not be explained by the main mechanism of natalizumab in MS (ie, attenuated lymphocyte recruitment).22,23 Although in natalizumab-treated MS patients significant numbers of HSPCs continuously circulate outside the protective BM environment, their likelihood to acquire deleterious mutations is probably small, given their G0 cycling status, but this possibility needs to be considered. Thus far, an increased propensity of natalizumab patients for hematologic malignancies has not been reported; however, further long-term observations are needed.
The usefulness of natalizumab as a priming agent for HSPC peripheralization is likely restricted only to patients receiving natalizumab for their underlying illness, given the risk of immunization against natalizumab24 and prolonged immune-modulating effects. However, CD49d blockade with short-acting small-molecule CD49d inhibitors, if efficacious, could be theoretically considered as treatment strategy for patient groups intolerant or unresponsive to G-CSF,10,25 especially in combination with other mobilizing agents, such as the CXCR4 antagonist AMD3100.26
Contribution: H.B. conceived of the studies, wrote the IRB protocol, obtained informed consent, performed experiments, collected and analyzed data, and wrote the paper; A.W. wrote the IRB protocol and recruited subjects; K.-H.C. performed experiments; S.L. recruited subjects; T.P. analyzed data and wrote the paper.
Conflict-of-interest disclosure: S.L. serves on the Speaker's Bureau for Biogen/Idec, manufacturers of natalizumab. The other authors declare no competing financial interests.
Correspondence: Halvard Bonig, Johann-Wolfgang-Goethe University, Institute for Transfusion Medicine and Immune Hematology, Sandhofstrasse 1, 60528 Frankfurt; e-mail: hbonig{at}u.washington.edu or hbonig{at}blutspende.de.
The authors thank the nursing staff of the 8SE infusion station at University of Washington Medical Center for their support.
This work was supported by a Core Center of Excellence in Hematology grant from the FHCRC (National Institutes of Health [NIH] DK56465 to H.B.) and by NIH grant HL58734 (T.P.).
The publication costs of this article were defrayed in part by page charge payment. Therefore, and solely to indicate this fact, this article is hereby marked "advertisement" in accordance with 18 USC section 1734.
- Submitted September 10, 2007.
- Accepted January 10, 2008.
- © 2008 by The American Society of Hematology


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text: New CHAT Workshop in Worthing next month CHAT Workshop for carers of adults with a learning disability We have a new Carers Health and Training workshop for carers of an adult with a learning disability coming up on April 3rd at the Chatsworth Hotel in Worthing. There are more details about the day and timings etc on the webpage here. Wednesday 3rd April Chatsworth Hotel, The Steyne, Worthing, BN11 3DU 10:00am- 2:15pm Lunch will be provided A day for carers to share and learn from each other and Learning Disability health professionals. Take time for you, meeting other carers and try a relaxation session.Learning Together Come, chat and share ideas about the person you care for. Communication – different ways to help people with a learning disability communicate Physical health – getting older with a learning disability Mental Health – recognising changes for people with a learning disability Sensory Needs – when might behaviour be a sensory issue Time For You Relaxation Take some time to try our guided introduction to relaxation. Informal time meeting other carers, health professionals and conversation. The CHAT project aims to encourage open peer to peer discussion, learning and support, with carers and LD health professionals working together. By alanlewis|2019-03-07T12:32:36+01:00March 5th, 2019|News Feed|Comments Off on New CHAT Workshop in Worthing next month Think Carer! Share this with a carer you know FacebookTwitterLinkedInRedditGoogle+PinterestEmail Related Posts


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Everyday is always a promo day for 2Go as another ticket sale offer comes your way!
It's not too late yet for that last minute decision to extend bonding moment with your love ones, barkadas or office mates since August is giving you your much needed holidays and long week ends. Thinking of your dream trip?
Superferry 2Go for once is extending another special sale in celebration of Ninoy Aquino Day. You may fine here details for our promo "2Go Boat Promo As Low As P600".
2Go Travel offers you a chance to travel to your desired place for as low as P600, P800 and P1,100 to all popular 2Go destinations in the Philippines. So, what are you waiting for? Go to your nearest 2Go office at mag book ka na!
2Go Boat Promo As Low As P600, P800, P1,100
2Go Ticket Promo P600
for destinations Batangas to/from:
- Caticlan
- Odiongan
- Roxas
- Romblon
P800 Promo Ticket Sale
Manila to Visayas
- Cebu
- Iloilo
- Bacolod
- Dumaguete
2Go Promo Ticket Sale P1,100
Manila to Mindanao
- Cagayan de Oro
- Ozamis
- Iligan
- Butuan via Nasipit
- Zamboanga
- Dipolog via Dapitan
Promo tickets are available for booking August 21, 2018 on your 2Go stores nationwide. Sailing period starts August 21 to the remaining days of the month of August 2018.
More and more promos are coming your way from your 2Go Travel company. We will be sharing it with you. So for more promo updates, just Like and Follow our Facebook Page: Superferry 2Go!!!
Please share information.


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Earlier this week we were invited to spend the day at Lightwater Valley theme park in Ripon, North Yorkshire. It's somewhere we've never been before but as it's only around an hours drive away we…View Post
Earlier this week we were invited to spend the day at Lightwater Valley theme park in Ripon, North Yorkshire. It's somewhere we've never been before but as it's only around an hours drive away we…View Post
Earlier this week was Max's 8th birthday, I'm really not sure how I'm old enough to have an eight year old. It's crazy! We started the day at Center Parcs, where we'd spent the weekend.…View Post
On Sunday Evie turned 6! I honestly have no idea how that happened, they grow up so quickly. I know that's such a cliché but it's so true, the years just fly by. I thought…View Post
I thought that I would sit down and do a little recap of 2018, it's certainly been a good one! I don't think we've been quite as busy as we were in 2017, but that…View Post
Over the past few weeks we have been taking part in the Shepherds Friendly Christmas savings challenge and I am honestly amazed at the amount of money we have managed to save! I wrote a…View Post
What does your Christmas Day usually look like? I guess for most of us there's lots of present opening and a Christmas dinner, but the rest is different from family to family and year to…View Post
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OK, so I've given in and decided that this year we are going to be doing Elf on the Shelf. We did try it a few years ago when the kids were really little but…View Post
When the weekends are filled with rain, icy winds and freezing temperatures, it can be difficult to get the kids to head outdoors and play, even on those rare occasions where it is dry. And…View Post
How to remove permanent marker pen… We have a brand new dining table in our house. It's white, which might not be the post practical colour with children around, but we went for it anyway.…View Post
Moving is complicated enough but when you add kids into the mix, it can become nightmarish. With all the work that goes into moving, you might not know how to make your kids feel better…View Post


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After the release of My Mines I in February 2002, Edgar continued touring, performing in locales such as New York City, the Miami Infiltrate, Vancouver, and several cities in Japan.On tour he incorporated visuals such as synchronized projections, and he also performed at the Detroit Electronic Music Festival in 2003, his debut as a Warp Records artist.Two years later, the Seattle Seahawks/Denver Broncos, from the NFC/AFC West, would continue this trend when they met each other for Super Bowl XLVIII.The Giants jumped to a 9–0 lead in the first quarter of Super Bowl XLVI before the Patriots scored 17 unanswered points to take a 17–9 lead in the third quarter.The stakes are high considering the scope of CKE, which has 3,800 franchised or company-operated restaurants in 44 states and 41 foreign countries.
The Giants defeated the Patriots by the score of 21–17.
Pitchfork Media wrote in a review that "There is no new ground being broken but that's not the point; Edgar comes across as a committed student, absorbing twenty-five years of electronic music and figuring out how to integrate and mold the history into something that sits comfortably in the now." One of them was X District, which started out as an accidental exchange of cryptic and symbolic writings between Edgar and Laura Clarke from Leeds.
These conversations and typed words ended up as the Color Correction EP on Noir Push Recordings in 2007.
It's also revamping its yellow star logo and bringing in a CEO to replace Andy Puzder, who is leaving after failing in his bid to become President Trump's Labor Secretary.
and Hardee's featured sexy TV ads with Paris Hilton and Kate Upton lustily devouring drippy hamburgers. With its customers demanding higher quality, the restaurant is making changes, starting with a TV ad campaign that openly mocks the sex-fueled formula that led to higher sales for years.


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|By Maureen O'Gara
Article Rating:
|December 18, 2009 01:30 PM EST
Cloud Computing Expo - Oracle expects the European Commission to wave its acquisition of Sun through next month MySQL and all without any annoying conditions.
Oracle president Safra Catz, who's been wrestling with the EC, said so when the company posted its fiscal second-quarter results Thursday, another reason Oracle's going to have a Merry Christmas.
Catz took a bunch of Oracle users to an EC hearing a week ago to buttress the company's claims that the EC had put words in users' mouths to support the theory of harm it manufactured to try to stop Oracle from getting MySQL.
Oracle Named Exclusive Diamond Sponsor of Cloud Expo 2010
The meeting was backed by a write-in campaign from hundreds of users as well as a letter from the US Senate and a public statement from the Justice Department.
A grateful Catz said, "I want to thank all of our customers for the overwhelming support they have given us during this process."
After further discussions with the agency over the weekend Oracle Monday made a few relatively non-restrictive promises regarding MySQL so the EC could leave the stage with its dignity intact. It still has until January 27. It will be curious to see it takes that long.
Oracle's CEO Larry Ellison, who blamed the EC's foot-dragging for Sun losing $100 million a month to rivals said he expects "Sun to rapidly improve both its market share and margins once this merger closes," claiming that "Sun's new Sparc Solaris system and Sun's new Exadata database machine both run the Oracle database faster than IBM's fastest computer."
Ellison reckons the Exadata-style business is the future of computing and worth billions of dollars.
During a conference call Ellison said Sun had no talent for selling high-volume, low-margin x86 machines and would leave that business to Dell and HP. Instead it will focus on the high-performance end peddling SMP machines and private clouds based on both Sun Solaris operating system and Oracle's Unbreakable Linux and complete with integrated storage and networking.
Oracle's Q2 beat the Street and the numbers hint that enterprise spending might be coming back into fashion again.
Oracle earned $1.46 billion, or 29 cents a share, up 15%, on revenues up 4% to $5.9 billion, pushing past the $5.69 billion expected. On a non-GAAP basis it realized 39 cents a share, three cents better than expected.
New software license revenues were up 2% to $1.7 billion, versus the $1.54 billion expected. Software updates and support revenues were up 14% to $3.2 billion.
The company's operating income was up 10% to $2.2 billion and operating margin was up 200 basis points to 37%. Operating cash flow on a trailing 12-month basis was $8.7 billion, up 7%.
In a prepared statement, CFO Jeff Epstein said, "We delivered results which were substantially better than we expected on both the top and bottom line, growing non-GAAP operating margins by 280 basis points to 49%, the highest Q2 non-GAAP operating margin in our history."
Oracle claimed it took market share from SAP in every region around the world for the fourth consecutive quarter. President Charles Phillips said that in constant currency, "our applications business grew 1% in the Americas and 2% in Asia Pacific versus a negative 35% and negative 34% respectively for SAP."
Catz said Sun, for all its losses, is still expected to bring Oracle $1.5 billion in operating income. Leaving Sun out – Oracle will redo its predictions next month – she forecast software license revenues to grow this quarter somewhere between minus 1% to up 9% and revenue to be up 3%-6% with non-GAAP ESP of 36 cents-38 cents
While the focus and objectives of IoT initiatives are many and diverse, they all share a few common attributes, and one of those is the network. Commonly, that network includes the Internet, over which there isn't any real control for performance and availability. Or is there? The current state of the art for Big Data analytics, as applied to network telemetry, offers new opportunities for improving and assuring operational integrity. In his session at @ThingsExpo, Jim Frey, Vice President of S...
May. 25, 2019 06:45 PM EDT Reads: 6,925
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life settl...
May. 25, 2019 03:30 PM EDT Reads: 14,660
@CloudEXPO and @ExpoDX, two of the most influential technology events in the world, have hosted hundreds of sponsors and exhibitors since our launch 10 years ago. @CloudEXPO and @ExpoDX New York and Silicon Valley provide a full year of face-to-face marketing opportunities for your company. Each sponsorship and exhibit package comes with pre and post-show marketing programs. By sponsoring and exhibiting in New York and Silicon Valley, you reach a full complement of decision makers and buyers in ...
May. 25, 2019 12:00 PM EDT
Two weeks ago (November 3-5), I attended the Cloud Expo Silicon Valley as a speaker, where I presented on the security and privacy due diligence requirements for cloud solutions. Cloud security is a topical issue for every CIO, CISO, and technology buyer. Decision-makers are always looking for insights on how to mitigate the security risks of implementing and using cloud solutions. Based on the presentation topics covered at the conference, as well as the general discussions heard between sessio...
May. 24, 2019 09:00 AM EDT Reads: 14,314
The Internet of Things is clearly many things: data collection and analytics, wearables, Smart Grids and Smart Cities, the Industrial Internet, and more. Cool platforms like Arduino, Raspberry Pi, Intel's Galileo and Edison, and a diverse world of sensors are making the IoT a great toy box for developers in all these areas. In this Power Panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists discussed what things are the most important, which will have the most profound e...
May. 22, 2019 10:30 AM EDT Reads: 7,225
The Jevons Paradox suggests that when technological advances increase efficiency of a resource, it results in an overall increase in consumption. Writing on the increased use of coal as a result of technological improvements, 19th-century economist William Stanley Jevons found that these improvements led to the development of new ways to utilize coal. In his session at 19th Cloud Expo, Mark Thiele, Chief Strategy Officer for Apcera, compared the Jevons Paradox to modern-day enterprise IT, examin...
May. 22, 2019 05:00 AM EDT Reads: 8,236
Rodrigo Coutinho is part of OutSystems' founders' team and currently the Head of Product Design. He provides a cross-functional role where he supports Product Management in defining the positioning and direction of the Agile Platform, while at the same time promoting model-based development and new techniques to deliver applications in the cloud.
May. 21, 2019 06:00 PM EDT Reads: 2,666
There are many examples of disruption in consumer space – Uber disrupting the cab industry, Airbnb disrupting the hospitality industry and so on; but have you wondered who is disrupting support and operations? AISERA helps make businesses and customers successful by offering consumer-like user experience for support and operations. We have built the world's first AI-driven IT / HR / Cloud / Customer Support and Operations solution.
May. 21, 2019 01:15 PM EDT
LogRocket helps product teams develop better experiences for users by recording videos of user sessions with logs and network data. It identifies UX problems and reveals the root cause of every bug. LogRocket presents impactful errors on a website, and how to reproduce it. With LogRocket, users can replay problems.
May. 21, 2019 12:15 PM EDT
Data Theorem is a leading provider of modern application security. Its core mission is to analyze and secure any modern application anytime, anywhere. The Data Theorem Analyzer Engine continuously scans APIs and mobile applications in search of security flaws and data privacy gaps. Data Theorem products help organizations build safer applications that maximize data security and brand protection. The company has detected more than 300 million application eavesdropping incidents and currently secu...
May. 21, 2019 11:45 AM EDT


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About Us
Our mission is The Great Commission. As daunting as the task may seem Jesus commanded us to "Go and make disciples of all the nations...." Today there is no better place to reach the nations than on the college campus or military base. These young men and women come from all over the world and our investment in them can pay eternal benefits as they leave us and go around the globe. The good news is that "all power has been given to (Jesus)" and He promises to to be with us even "to the end of the age." We are excited to see how the Lord works in the coming years.


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So then, what is it…
What is the SECRET to getting in shape..? I tell you what, if you read every word of this email, you may just find out.. 🙂
"The SECRET diet pill to get you in shape!"
I hear ya, but surely i need to eat less than what i burn..?
The simple answer is yes..
This is often the question that is bounded about in the fitness industry for anyone who wants to get in shape…
….so then, what diet is best..?
I would say all of them work…BUT..
The idea is to put the body into a calorie deficit…(eat less than what you burn)
I.e if you burn 2500 and eat 2300, then you will lose weight in a sustainable way in a slight calorific deficit…make sense..?
Split up your carbs, Proteins and Fats (50, 40, 10) for the best results.
And you will find that this is the simplest way for you to keep in control of any fat gain issues..
Bullshit alert..
…You could go and spend £85 on some kinda fat burner, eat what you want and not worry about working out, or being in a slight deficit….WRONG..!
The secret pill…
The XLS medical fat absorption pill is the Number 1 brand….it really works….BUT…
"Only if you use them as part of a calorie controlled diet with exercise".…are you kidding me..?
These companies, make an absolute fortune out of our desperation to be in shape and it is wrong…
If you eat in a slight calorie deficit, increase your protein levels and workout 3 x per week, this will also work and it will save you putting £85 down the toilet….
Please stop looking for the easy option…it is hard, but it will be worth it.. 🙂
Talk soon,
Sean Cole
P.S. Loads of tips coming this year, its going to be a great 2018 for free tips….stay tuned.


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Have just been out picking up the Christmas Tree. We're back to the news that there's a ban on the sale of alcohol from midday today until midday Sunday in all the shops. Don't worry we stocked up with some Glühwein! from IKEA while we were there. Restaurants and Bars will still be able to sell though.
Things are definitely heating up in France this weekend. 89,000 police called into action and 12 heavy duty vehicles? (Do they have water canons?)
You can read move https://www.ouest-france.fr/pays-de-la-loire/nantes-44000/nantes-saint-nazaire-vente-d-alcool-interdite-des-ce-vendredi-6115884


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Series Objectives 1. Review social emotional development through the lens of Infant and Early Childhood Mental Health. 2. Understand behaviors young children exhibit through the lens of attachment, relationship, trauma and culture. 3. Partner with parents to promote healthy parent-child relationships which support development. 4. Identify and integrate specific strategies to use when working with young children and their caregivers to contribute to healthy social emotional development.
Webinar 3: April 25th 6:30-8:30 Tracy Schreifels and Arielle Handevidt
I Wonder: Using Curiosity to Understand and Address Children's Behavior
Course ID 136962
What if caregivers used their curiosity to resolve challenging behaviors? Learn how to use reflective thinking to understand how development, trauma, and attachment influence behaviors. Behavior is a form of communication that caregivers can learn to interpret when time is taken to process the meaning. Explore a toolbox of strategies for preventing and addressing behavior in infants, toddlers and preschoolers.
KCF Area(s) II.C: Promoting Social and Emotional Development (2 Hours)
Content Area III: Positive ways to support children' social and emotional development (2 Hours)
April 25th, 2019 6:30 PM through 8:30 PM
1000 Western Avenue
Fergus Falls, MN 56537
United States
Fergus Falls, MN 56537
United States
Email: firstname.lastname@example.com Email: firstname.lastname@example.com