text:
We developed The Pool's award-winning content platform, with its unique content model and stand-out user experience:
- Winner at the 5th annual Online Media Awards for 'Technical innovation'
- Winner at the 21st Annual Webby Awards for 'Best lifestyle mobile site and app'
- Winner at the 7th annual Lovie Awards for 'Websites, Lifestyle' & 'Mobile Sites, Lifestyle'
The challenge
Founded by Sam Baker, former editor-in-chief at Cosmopolitan, and BBC Radio 6's Lauren Laverne, The Pool is a pioneering digital publication for women 'too busy to browse'.
Inspired by the radio broadcast model, original content on everything from politics, to film and fashion is published during specified timeframes to enhance its relevance to readers.
The Pool required a powerful technology framework to support its unique model. Content needed to operate on a radio-broadcast-style schedule, with regular 'drops' throughout the day and night.
And with many of the publication's contributors needing to publish directly into the content management system, it was imperative that content editors had access to a simple, easy-to-use administrative system supporting a powerful publication workflow.
With a strong focus on how its content is consumed, The Pool was looking to deliver a differentiated user experience that makes it easy and enjoyable for readers to find relevant content at the right time, regardless of whether they're browsing on a laptop or a mobile.
What we did
We built a fully-responsive website using a powerful publishing platform based on Pimcore. This open-source content management system was identified as the right fit for The Pool's complex demands, thanks to its support for bespoke functionality.
The administrative system for content editors is straightforward and includes a publication workflow, so content can be seamlessly approved by The Pool's editorial team. The administrative system replicates the look and feel of the actual templates, providing content areas that can be edited, and drop zones that can be populated with different types of media. The result is a simple, powerful content management experience.
The Pool's content is housed in a groundbreaking 'timed wheel', a mechanic that allows users to scroll back and forth to view the day's programme.To ensure the broadcast model was incorporated into the technology, we built a broadcasting tool to automatically post content at the correct times.
The frontend stack was chosen to ensure a fast, responsive, and mobile-optimised user experience across all devices.
One of the reasons we designed The Pool as mobile-first, and then built it up, is that everything we do, we do with our user in mind.
Sam Baker, founder, The Pool
The results
Following the site launch, The Pool has gained recognition as a pioneering new media platform that puts the needs of its readers first.
The publication was awarded the 'Technical innovation' accolade at The Drum Online Media Awards 2016, The Webby People's Choice award for 'Best lifestyle mobile site and app' in 2017, and was a winner in the 7th Annual Lovie Awards for 'Websites, Lifestyle' and 'Mobile Sites, Apps & Podcasts, Lifestyle'.


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text: Bacterial Toxins: Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.Cholera Toxin: An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.ADP Ribose Transferases: Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.Streptolysins: Exotoxins produced by certain strains of streptococci, particularly those of group A (STREPTOCOCCUS PYOGENES), that cause HEMOLYSIS.Cytotoxins: Substances that are toxic to cells; they may be involved in immunity or may be contained in venoms. These are distinguished from CYTOSTATIC AGENTS in degree of effect. Some of them are used as CYTOTOXIC ANTIBIOTICS. The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS.T-2 Toxin: A potent mycotoxin produced in feedstuffs by several species of the genus FUSARIUM. It elicits a severe inflammatory reaction in animals and has teratogenic effects.Enterotoxins: Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.Hemolysin Proteins: Proteins from BACTERIA and FUNGI that are soluble enough to be secreted to target ERYTHROCYTES and insert into the membrane to form beta-barrel pores. Biosynthesis may be regulated by HEMOLYSIN FACTORS.Toxins, Biological: Specific, characterizable, poisonous chemicals, often PROTEINS, with specific biological properties, including immunogenicity, produced by microbes, higher plants (PLANTS, TOXIC), or ANIMALS.Exotoxins: Toxins produced, especially by bacterial or fungal cells, and released into the culture medium or environment.Bacterial Proteins: Proteins found in any species of bacterium.Tetanus Toxin: Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.Adenosine Diphosphate Ribose: An ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.Diphtheria Toxin: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.Antitoxins: Antisera from immunized animals that is purified and used as a passive immunizing agent against specific BACTERIAL TOXINS.Adenylate Cyclase Toxin: One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin components.Escherichia coli Proteins: Proteins obtained from ESCHERICHIA COLI.Botulinum Toxins, Type A: A serotype of botulinum toxins that has specificity for cleavage of SYNAPTOSOMAL-ASSOCIATED PROTEIN 25.Marine Toxins: Toxic or poisonous substances elaborated by marine flora or fauna. They include also specific, characterized poisons or toxins for which there is no more specific heading, like those from poisonous FISHES.Botulinum Toxins: Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.Virulence Factors: Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)Bacillus anthracis: A species of bacteria that causes ANTHRAX in humans and animals.rho GTP-Binding Proteins: A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin organization, gene expression and cell cycle progression. This enzyme was formerly listed as EC 188.8.131.52.Shiga Toxins: A class of toxins that inhibit protein synthesis by blocking the interaction of ribosomal RNA; (RNA, RIBOSOMAL) with PEPTIDE ELONGATION FACTORS. They include SHIGA TOXIN which is produced by SHIGELLA DYSENTERIAE and a variety of shiga-like toxins that are produced by pathologic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Furin: A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.Colicins: Bacteriocins elaborated by strains of Escherichia coli and related species. They are proteins or protein-lipopolysaccharide complexes lethal to other strains of the same species.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Shiga Toxin 2: A toxin produced by certain pathogenic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157. It shares 50-60% homology with SHIGA TOXIN and SHIGA TOXIN 1.Pertussis Toxin: One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.Shiga Toxin 1: A toxin produced by certain pathogenic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157. It is closely related to SHIGA TOXIN produced by SHIGELLA DYSENTERIAE.Pore Forming Cytotoxic Proteins: Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.Superantigens: Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.Immunotoxins: Semisynthetic conjugates of various toxic molecules, including RADIOACTIVE ISOTOPES and bacterial or plant toxins, with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; and ANTIGENS. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect.Clostridium perfringens: The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Virulence Factors, Bordetella: A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.Shiga Toxin: A toxin produced by SHIGELLA DYSENTERIAE. It is the prototype of class of toxins that inhibit protein synthesis by blocking the interaction of ribosomal RNA; (RNA, RIBOSOMAL) with PEPTIDE ELONGATION FACTORS.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Staphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.GTP-Binding Proteins: Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.NAD: A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)Kinetics: The rate dynamics in chemical or physical systems.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Protein Transport: The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.rhoA GTP-Binding Protein: A RHO GTP-BINDING PROTEIN involved in regulating signal transduction pathways that control assembly of focal adhesions and actin stress fibers. This enzyme was formerly listed as EC 126.96.36.199.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Scorpion Venoms: Venoms from animals of the order Scorpionida of the class Arachnida. They contain neuro- and hemotoxins, enzymes, and various other factors that may release acetylcholine and catecholamines from nerve endings. Of the several protein toxins that have been characterized, most are immunogenic.Receptors, Cell Surface: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.Clostridium difficile: A common inhabitant of the colon flora in human infants and sometimes in adults. It produces a toxin that causes pseudomembranous enterocolitis (ENTEROCOLITIS, PSEUDOMEMBRANOUS) in patients receiving antibiotic therapy.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Endocytosis: Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.Mycotoxins: Toxic compounds produced by FUNGI.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.CHO Cells: CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.Lipid Bilayers: Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Liposomes: Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Lipopolysaccharides: Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Protein Structure, Secondary: The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Neuromuscular Agents: Drugs used for their actions on skeletal muscle. Included are agents that act directly on skeletal muscle, those that alter neuromuscular transmission (NEUROMUSCULAR BLOCKING AGENTS), and drugs that act centrally as skeletal muscle relaxants (MUSCLE RELAXANTS, CENTRAL). Drugs used in the treatment of movement disorders are ANTI-DYSKINESIA AGENTS.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Scorpions: Arthropods of the order Scorpiones, of which 1500 to 2000 species have been described. The most common live in tropical or subtropical areas. They are nocturnal and feed principally on insects and other arthropods. They are large arachnids but do not attack man spontaneously. They have a venomous sting. Their medical significance varies considerably and is dependent on their habits and venom potency rather than on their size. At most, the sting is equivalent to that of a hornet but certain species possess a highly toxic venom potentially fatal to humans. (From Dorland, 27th ed; Smith, Insects and Other Arthropods of Medical Importance, 1973, p417; Barnes, Invertebrate Zoology, 5th ed, p503)Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Ricin: A protein phytotoxin from the seeds of Ricinus communis, the castor oil plant. It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Neurotoxins: Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.Clostridium botulinum: A species of anaerobic, gram-positive, rod-shaped bacteria in the family Clostridiaceae that produces proteins with characteristic neurotoxicity. It is the etiologic agent of BOTULISM in humans, wild fowl, HORSES; and CATTLE. Seven subtypes (sometimes called antigenic types, or strains) exist, each producing a different botulinum toxin (BOTULINUM TOXINS). The organism and its spores are widely distributed in nature.Mice, Inbred BALB CBacillus thuringiensis: A species of gram-positive bacteria which may be pathogenic for certain insects. It is used for the biological control of the Gypsy moth.Spider Venoms: Venoms of arthropods of the order Araneida of the ARACHNIDA. The venoms usually contain several protein fractions, including ENZYMES, hemolytic, neurolytic, and other TOXINS, BIOLOGICAL.Cnidarian Venoms: Venoms from jellyfish; CORALS; SEA ANEMONES; etc. They contain hemo-, cardio-, dermo- , and neuro-toxic substances and probably ENZYMES. They include palytoxin, sarcophine, and anthopleurine.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Mice, Inbred C57BLToxoids: Preparations of pathogenic organisms or their derivatives made nontoxic and intended for active immunologic prophylaxis. They include deactivated toxins. Anatoxin toxoids are distinct from anatoxins that are TROPANES found in CYANOBACTERIA.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Vibrio cholerae: The etiologic agent of CHOLERA.Protein Biosynthesis: The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.Exfoliatins: Protein exotoxins from Staphylococcus aureus, phage type II, which cause epidermal necrolysis. They are proteins with a molecular weight of 26,000 to 32,000. They cause a condition variously called scaled skin, Lyell or Ritter syndrome, epidermal exfoliative disease, toxic epidermal necrolysis, etc.Killer Factors, Yeast: Protein factors released from one species of YEAST that are selectively toxic to another species of yeast.Endotoxins: Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.Bordetella pertussis: A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.Sea Anemones: The order Actiniaria, in the class ANTHOZOA, comprised of large, solitary polyps. All species are carnivorous.Anthrax: An acute infection caused by the spore-forming bacteria BACILLUS ANTHRACIS. It commonly affects hoofed animals such as sheep and goats. Infection in humans often involves the skin (cutaneous anthrax), the lungs (inhalation anthrax), or the gastrointestinal tract. Anthrax is not contagious and can be treated with antibiotics.Shellfish Poisoning: Poisoning from toxins present in bivalve mollusks that have been ingested. Four distinct types of shellfish poisoning are recognized based on the toxin involved.Enterocolitis, Pseudomembranous: An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization.Clostridium Infections: Infections with bacteria of the genus CLOSTRIDIUM.Lethal Dose 50: The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.Trihexosylceramides: Glycosphingolipids which contain as their polar head group a trisaccharide (galactose-galactose-glucose) moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in ceramide trihexosidase, is the cause of angiokeratoma corporis diffusum (FABRY DISEASE).Pest Control, Biological: Use of naturally-occuring or genetically-engineered organisms to reduce or eliminate populations of pests.Corynebacterium diphtheriae: A species of gram-positive, asporogenous bacteria in which three cultural types are recognized. These types (gravis, intermedius, and mitis) were originally given in accordance with the clinical severity of the cases from which the different strains were most frequently isolated. This species is the causative agent of DIPHTHERIA.Shigella dysenteriae: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that is extremely pathogenic and causes severe dysentery. Infection with this organism often leads to ulceration of the intestinal epithelium.G(M1) Ganglioside: A specific monosialoganglioside that accumulates abnormally within the nervous system due to a deficiency of GM1-b-galactosidase, resulting in GM1 gangliosidosis.Trichothecenes: Usually 12,13-epoxytrichothecenes, produced by Fusaria, Stachybotrys, Trichoderma and other fungi, and some higher plants. They may contaminate food or feed grains, induce emesis and hemorrhage in lungs and brain, and damage bone marrow due to protein and DNA synthesis inhibition.Clostridium: A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.Elapid Venoms: Venoms from snakes of the family Elapidae, including cobras, kraits, mambas, coral, tiger, and Australian snakes. The venoms contain polypeptide toxins of various kinds, cytolytic, hemolytic, and neurotoxic factors, but fewer enzymes than viper or crotalid venoms. Many of the toxins have been characterized.Elapidae: A family of extremely venomous snakes, comprising coral snakes, cobras, mambas, kraits, and sea snakes. They are widely distributed, being found in the southern United States, South America, Africa, southern Asia, Australia, and the Pacific Islands. The elapids include three subfamilies: Elapinae, Hydrophiinae, and Lauticaudinae. Like the viperids, they have venom fangs in the front part of the upper jaw. The mambas of Africa are the most dangerous of all snakes by virtue of their size, speed, and highly toxic venom. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p329-33)Biological Assay: A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.Saxitoxin: A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poison found in certain edible mollusks at certain times; elaborated by GONYAULAX and consumed by mollusks, fishes, etc. without ill effects. It is neurotoxic and causes RESPIRATORY PARALYSIS and other effects in MAMMALS, known as paralytic SHELLFISH poisoning.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.


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He decides to try a bit of a cocky thing. The horny masseur gets on his feet and starts fucking the brunette while a blonde fingers her clit. Sex obsessed slut seduces a stranger and has a lot of intense squirting orgasms. As much as I tried not to, I just had to jam my cock really deep down her throat. The naked babe wrapped her legs around him tightly, kissing and biting his neck.
My god she was beautiful and it was the greatest blowjob ever.
HardcoreSister and BrotherTeen Sex. Orgasmic massage ends with the masseur fucking two smoking hot babes. Brings Cheerleader First sexual experience with nimble She loves sex and she loves to seduce strangers. Our incompetent nanny gets punished by bondage orgasm.


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When hundreds of women marched topless through the streets of New York and other cities last summer - part of the 8th Annual GoToplessDay - their protest on behalf of gender rights exposed far more than bare skin. That's because they were the just the latest in a long line of protesters who are focused on changing culture before they change any laws.
Needless to say, the media - photo buffs in particular - had a field day, giving this issue some truly 'out-sized' attention.
The protesters chose to bare it all in honor of Women's Equality Day, which commemorates the pivotal movement in August 1920 when women earned the right to vote. For the protest participants, being able to go topless was another right grounded in gender equality, just as a women's right to vote once was. While judges in the state of New York have ruled in favor of a women's right to go topless in public, most other places have yet to follow suit.
The marchers believed that only total transparency of a breast-defying nature would lead lawmakers across the country to change archaic laws.
It's a controversial approach that could bear fruit in the current presidential race when it comes to campaign finance reform.
When the Supreme Court ruled in Citizens United that corporations could fund candidates as if they were individuals, many threw up their hands in dismay. How easy it would be to hide behind a non-individual entity!
The antidote might be an act of "disruptive transparency" that finds common ground with the disrobing female protesters in New York. In campaign finance reform, of course, the goal is not to remove one's clothing, but to unveil the names of one's campaign donors.
The idea is simple and targeted. A candidate who believes that campaign finance reform is critical to the future of our democracy would step forward to set a new standard. Every ad, website and social media communication would include the names of the candidate's top three donors - whether it be an individual, corporation or labor union. This new standard of transparency would send a signal to all of the candidate's SuperPacs and political nonprofit groups that they, too, must publicly disclose the names of their donors. The information would be audited by two reputable accounting firms. It's a basic process that would be verifiable and, quite possibly, disruptive.
The presidential candidates should declare that public service begins with being public. It would mark a new starting point for political campaigns and create a new set of expectations. If Bernie Sanders were first, he would set The Sanders Standard.
The purpose of this approach is to garner a reaction - changing culture before changing laws in a way that forces other candidates to follow suit. It follows a long line of protestors who have used disruptive transparency as their weapon of choice when it comes to social change.
Those topless marchers in New York? Their protest on behalf of women's civil rights forced a reaction that continues a debate about issues once considered below the radar, if not below the belt.
When millions of gay men and women came out of the closet, they provoked a reaction among their families, friends, co-workers and neighbors. Gay marriage was not on the minds of these closet exiters -but their very presence in the midst of our daily lives made us reconsider who gets to enjoy a walk down the aisle. Our culture had to change before it was reflected in our laws.
Or consider the recent tribunal in Guatemala that revealed in detail how top government officials used their positions to steal public money. After years of hopelessness, the corrupt president of Guatemala resigned and citizens ushered in a new era of transparency.
People aspiring to public office often trumpet endorsements from elected officials, professional groups and other public figures. How can they take pride in these supporters and not from those who are actually funding their campaigns? Pride in ownership should be a standard starting point for public figures.
Indeed, in the Citizens United case, all but one justice reaffirmed the constitutionality of disclosure requirements for election-related spending. According to the court, disclosure laws serve governmental interests in "providing the electorate with information" which allows voters to "make informed choices in the political marketplace."
Lest you think that no public official would have the courage to go public with the names of his real supporters, consider these ringing words from the 2010 Supreme Court ruling in Doe vs. Reed:
"Requiring people to stand up in public for their political acts fosters civic courage, without which democracy is doomed." Those are words of Antonin Scalia. How could the Koch brothers find fault with him?
Down the road there will be ballot initiatives, new legislation, constitutional amendments and elections galore. But why wait? Any presidential candidate could step forward tomorrow to set a new standard.
Who will be the first candidate to go 'topless" in this year's election parade?
Michael M. Appell (left) is a senior lecturer at Brandeis University's Heller School for Social Policy and Management and the assistant director of Heller's MBA in Nonprofit Management program. Gary L. Appell (right) is a volunteer with the California Clean Money Campaign.


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Acne is fast glowing and mostly seen problem in day today life. Not a single one wants the acne because it will feel uncomfortable about their skin. You want to learn how to take care proper the skin in deeply with help of the natural skin care tips. Take care of skin in not a completed it will simple. If you are not able to wash your skin properly during the night then also there is no issue you can recover your skin radically and fast, lacking extra injurious in your skin. There is most important to use only recommend and FDA approve product should be use to get rid form acne. But the acne treatment products are costly and heaving of impractical to pronounce element. So there is best way to use natural remedy to overcome the acne problem.
Natural Acne treatment for skin care
Ice is best option to overcome the acne on the skin. You should have to use ice to area of your pores and decrease redness. If you have more amount of acne on your skin then take the ice cubes and gently hold on the acne are or give massage on that affected are. Ice has cold nature when he comes in contact in blood vessels under the skin then it will reduce the irritation or redness or inflammation and make it's a lesser amount of noticeable.
Tea tree oil:
Tea tree oil contains the anti-fungal and antibacterial property. It is pure herbal medicine containing 100% safe and effective. It will help to gently moderate the acne problem.
Benzoyl Peroxide:
Benzoyl Peroxide is also best medicine to get hill form acne problem. It will treat mild to moderate acne. You can use it on only affected are of your skin. Keep avoid use of Benzoyl Peroxide cream in the sensitive area like nose, eye, mouth and in the area of broken skin because it will cause irritation.
In the study of Tea tree oil and Benzoyl Peroxide comparison, it will prove that Tea tree oil will give better effect on getting rid form acne form skin. It will overcome or fight with the acne and dropping the cut on the skin. Benzoyl Peroxide will give fast result as compare to the Tea tree oil, but Tea tree oil has not providing any side effect on user.
Egg oil:
Egg yolk oil is containing immunoglobulins. It is help to overcome on the bacteria infection and also boost to decrease the inflammation. You can get heel form pimples without putting any acne scars on the skin with help out of Omega 3 fatty acids.
Process to use Egg oil:
Egg oil should be applied two times in a day on the affected area of skin means on acne. Give proper massage at least 2 to 3 minutes on the acne area.
Wash your skin after the one hour when it completed get absorbed in to skin with face wash.
You should have to follow this acne treatment up to your skin get completed clean or remove all acne and pimples on the skin and your skin will look like healthy and acne less glowing. If you stop this process in the middle then there is chance to get spread the acne again on the skin.
Make a slice of the row potato and apply that on the affected area of skin like on acne. Row potato will act as a anti-inflammatory which is best medicine to get heal form the acne problem. After some time wash your skin properly with the water.
Apply the honey on the affected area of skin on acne part. Or you may use honey with the combination of water or green tea. Wait at least 15 to 20 minutes up to it get completely get absorbed in to the skin or get dry completely. Clean your skin with the normal water and make the skin dry with cotton. Use some moisturized cram after using honey on the skin.


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1. Do not overbook yourself
It is so easy to roam around the club fair, see ads on Facebook for different events or simply think you are superhuman that can do everything but I promise as much as you try, you aren't. In college, it is most important to focus on yourself first and then classes. Find one or two things you are most passionate about and dive head first into those instead of giving 50% into 8 things.
2. Try new things
Even if you find out the rugby team is not for you there was no harm in trying it, right? Use this time to try new things and find out what you like to spend your time doing.
3. Go to the library
I know everyone says it but I am guilty of it too. I did not use the library as much as I should have my freshmen year and I can tell you it is worth it to use it. It is multi-purposeful. I mean you can bring a blanket and take a nap, print things and write out your whole life story while sitting in the library.
4. Use a planner
My planner is my lifeline to everything I commit to in college. You may not think you need to organize yourself with a planner but trust me, you will forget something if you do not have it.
5. Eat and exercise regularly
Grades aren't everything in life. You come first. Make sure to take time for yourself. Whether that is getting up a few minutes earlier to get breakfast from the dining hall or to get a work out it, then so be it because you will be happier you did it in the long run.
6. Organize your study space once in a while
Nothing makes me more anxious than coming back to a messy room especially a messy study space. It is proven that if you tidy your study space it will give you more motivation to get your studies done.
7. Be yourself
Going into freshmen year everyone says it is a time to re invent yourself. Do not try to be anyone but yourself because the friends you make or the friends you will want to have are the ones who will love you for YOU.
8. Cherish each moment
College goes by fast especially freshmen year so cherish every moment and the opportunity it hands you.
9. Study
I mean at the end of the day you aren't paying thousands of dollars to party every night (shocking, I know) so prioritize your time so you can enjoy your experience.
10. Call your parents
Nothing will make your parents day more than giving them a call every so often. You can deny it all you want but at some point you will miss your parents, I promise.


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I was Introduced to Drexina Nelson through stylist Lamont Lawrence and as I prepped for the interview, I was not ready. I believe the word that I used to describe her was 'overwhelming'.
This lady is a production studio boss, a creative, and self-proclaimed workaholic who has worked with everyone from Idris Elba to Nene Leakes.
Drexina is from Georgia originally, raised in Texas but moved back to Georgia for high school. She was raised in a culturally diverse environment which has given her an appreciation for the melting pot that we currently live in.
She started her career as a makeup artist and wanted more out of the profession. She decided to learn photography and eventually created a full-service production studio called The Society Studios located in Atlanta Georgia.
Drexina is driven and when you talk to women who are constantly creating and working it is difficult to avoid the inspiration that they naturally give you. If you are a photographer with dreams of taking your work to the next level you need to read this interview:
1. What drives you, How do you stay motivated daily?
The thing that drives me the most is my mind and spirit. My mind is constantly on overdrive. I have a zillion and one ideas, however, it is my spirit that leads me to know which one takes precedence over the other.
I am in a place right now where what drives me the most is being true to myself and my creativity. I believe that creativity is a special gift, and one that must be utilized appropriately.
I stay motivated daily by constantly staying centered, in the moment, and thriving for excellence. I rarely sleep because my mind is constantly churning out ideas.
I stay motivated because I understand that while I am here I have a mission to accomplish… I have a purpose on this journey… I believe that until I reach my final destination, I am always learning and pushing for growth. That is what motivates me.
2. How did you transition from makeup artist to a production studio badass – describe that process including the moment you realized you wanted more than just 'make up'.
I started dabbling in makeup during my youth however in 2005 I was at a crossroad. I was at a point where I had to make a decision to either continue working in corporate America or to live my dreams as a creative.
The decision to leave corporate America came when I had the opportunity to meet with a local agency that represented makeup artists.
The agent took a look at my portfolio and told me that my work was good however I must work with better photographers.
I made the decision at that moment to learn photography myself and to begin shooting my makeup work. Over time however, I began to fall in love with photography more than makeup. By 2006, I was no longer doing makeup and made strides to fulfill my new direction as a professional photographer.
3. What is The Society Studios?
The Society Studios is something super special to me. I like to call my studio a beauty production facility, as we can handle the production of a beauty project from concept to creation.
Our team works hard to help companies realize their true vision, and then we also help them to birth it. I believe that many companies just need a good creative doctor to help them bring their vision to life and that's what the studio strives to do. Our motto is Your Vision. You Create. We Capture It.
I believe that sums up what we do. We assist our clients with creating long lasting, awe-inspiring imagery that exceeds their expectations.
4. What is the client experience like when they work with you?
At the Society Studios, our goal is to make our productions as seamless as possible. Our team is BIG on the experience of each of our clients.
Our facility is the first part of the experience because we have taken the time to put our hearts and soul into each detail of our facility.
On the wall are positive words that we as a team stand for. We make sure the music is upbeat, and there is a zesty lemongrass fragrance in the air.
We want to ensure that our clients have a positive experience from start to finish. We work in a non-stressful and drama free environment. All of our clients become like family to us, and we believe in taking care of our family!
5. Who was your first celebrity client and what was that shoot like?
My first celebrity shoot was with Akon. I met Akon through a friend that was his stylist at the time. She had a client that was a furrier, and they wanted to use him as the face of their campaign. The shoot was very easy and seamless. It was the beginning of the fast acceleration of my photography career in Atlanta.
6.Do you ever come out of a shoot with a bit of doubt, thinking, "That could have been better" or "I am not 100% happy with that" ?
There have been many occasions where I was not happy with a shoot. There are so many elements that as a professional you still can not prepare for.
For instance, if a model is beautiful but she cannot move, a celebrity client is late, or many obstacles like that can throw off the creative energy causing the production to go in a much different direction.
Many times however, if I take a step back and re-evaluate the images once I release the visual that was initially in my mind, I find that the images are never as bad as I thought.
Many times, it is the thought that because the image did not materialize the way that I thought that it would be considered a failure.
I have learned that I had to let go of my perception of what I wanted, and love it for what it was even if I was not 100% thrilled with the outcome. I have also learned that these instances are when I grow as a creative.
7. Describe a low point in your career, and how you overcame it?
The lowest point in my career was actually last year. 2016 was a rough year. While I don't consider it professionally a failure, I was not in the mental space to perform.
I had a major death… actually a murder in my family that took my mind in a totally different direction. This was a
low point because at one moment, I thought that I would not make it through. How dare I continue to move forward in prosperity while a person that I love so much sits in an urn?
I was hurt to my heart and did not see the silver lining or the light at the end of the tunnel. 2016 was a dark time for me, and I felt totally alone.
I had to make a concerted effort to pull myself out of the wreckage. I had to go back to change my state of mind. I was a warrior… A victor and not a victim!
Although my loved one is no longer here, I had to make the choice to pull though. I truly know that he would not want me to fail. He was always so proud of my journey.
Though this trial, I have learned to be true to who I am as a creative and what I want as an individual. I am no longer looking outward for validation or looking for acceptance from others.
I had to learn that what I have as a creative no one else has, and that is worth its weight in gold. I believe that I am much stronger than I was yesterday, and I live in the belief that Marques is guiding my way each and every moment.
8. What would you tell an up and coming photographer who wants to get a bit more creative by starting a production company, what is the best advice you could give to that person?
My best advice to a new photographer is to study and to find a mentor that they admire. The best way to success is to be around it, and to study it.
As they say, if you are the smartest one in your group then it's time to get another group. I believe that new photographer should shoot many genres prior to getting fixated on one.
Over time their style and niche will happen organically. My thoughts are that time is the best teacher so never rush progress. Just enjoy the process.
9. Would you describe yourself as a risk taker?
I am most definitely a risk taker however I can honestly say that there have been times where fear has challenged me to move forward. At this point I realized that most fears are not life or death so I continue to fight to create… regardless of what the little voice in my head says at times.
10.Describe the hardest shoot or production you have ever done?
On production, you never know when you will have a technical difficulty. One of the hardest production was my first time shooting for the reality show Housewives of Atlanta.
The reason this was so difficult was because I was not aware that their equipment shut down all of my wireless transmitters at the time.
I thought that all of my equipment just chose to not work on the day that we were filming for national television. Luckily, I was able to figure out that their equipment was super powerful and I was able to use my older cords and equipment to get through the shoot. That was almost a nightmare!!
11.If you could pick one celebrity client that is your fave who would it be (You can pick more than one)
I can say that I have so many celebrity clients that I love working with. It is truly difficult to name them as I don't want to leave anyone out!
Me – Fair enough!
12. Looking back, what would you tell your 15yr old self?
I would tell my 15-year-old self that she beautiful, smart, unique, and amazing just the way she is. There is no such thing as perfection.
I would also tell her to trust her intuition as her guide in life, don't take no as the final answer, believe in herself, stop looking to others for approval, don't be afraid to shine, and to value each moment of this life….
Lastly, I would tell her that no matter how successful she ever becomes that family is the most amazing gift that was given to her… and to cherish that with everything.
I want to thank Drexina for allowing me to share her story with my audience you are truly an inspiration to us all the epitome of #Blackgirlmagic. You can find Drexina on Instagram here and on here website here.


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Print wristbands and inpatient labels with one device
The WS2 is a hygienic, compact direct thermal desktop printer from SATO ideal for various healthcare scenarios. Suitable for direct use in the hospital ward due to its disinfectant-ready, antimicrobial plastic casing, the WS2 prints both patient ID wristbands and inpatient labels quickly and accurately for optimum patient safety and operator peace of mind. The WS2 is also offered bundled with SATO patient ID wristbands as part of a competitive package, making the need to hand write labels a thing of the past.
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An activation code is a code adapted activate a hardware system, software, inventory, or leave behind to ensure that it for use.
Another simple and single audio editor. Theres minute allowance significantly particular concerning this one, however it's going to meet basic audio modifying wants.
This suite provides you 4 of the world's finest education software program instruments, premeditated specifically to work by means of sensible Boards, combine by means of units and coin studying engaging and interactive.
What are the totally different kinds of software program?
Reduces exchange retailer measurement utilizing an built-in HSM (Hierarchical Storage management) e mail archiving software directs all .PSTs, e-mails and their attachments to a major storage medium. discrete instantaneous Storage (SIS) removes duplicates, stores the unique electronic mail and its attachments onto a less expensive storage section, and leaves astern a hyperlink on change. The link is on average 1KB. It usually cuts the amount of the exchange server as much as 80%.
Is start on-supply software profitable?
mp3 normalizer - TimeEmail archiving removes duplicate recordsdata thus there may be less to again . you too can the software program to define archiving processes, automating the .
Where can i discover mP3 nORMALIZER and start-source software?
VLC (initially VideoLAN shopper) is a highly transportable multimedia participant for varied audio and video codecs, including MPEG-1, MPEG-2, MPEG-4, DivX, MP3, and OGG, in addition to for DVDs, VCDs, and numerous...
Alpha-model" denotes development status, not value. a few alpha versions are available at no cost, some or not. regardless of cost, it is typically not advisable to make use of alpha model software except meager amount else is accessible, since it usually accommodates bugs that may [hopefully
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thread: 2012-03-06 : Chad Underkoffler: Freelancing for RPGs
On 2012-03-07, David Berg wrote:
Chad, thanks for the response. Sorry for asking you to speculate about stuff you haven't dealt with firsthand; I'm still glad to hear your experiences as an observer of such issues. "Ask their other freelancers" makes sense to me... I guess there isn't any magic secret, huh?
As a freelance web designer, my experiences are quite different from everything discussed here.


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There is a growing trend amongst men now that smearing a blob of borrowed moisturiser over razor rash and remembering to squirt some deodorant on is no longer acceptable. It is however an overwhelming market for the "every day" gent who simply wants a productive but effective skincare regime and buying hundreds of products isn't the answer. In celebration of Men's Health Awareness Week we have tackled this issue and here are our top ten tips
Here is our simple guide to what you need to do to ensure that those ten minutes in the bathroom are productive


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"I don't mind if you don't like my manners. They're pretty bad. I grieve over them during the long winter evenings. But don't waste your time trying to cross-examine me."
I think that the situation in which this witness stands towards either party, does not give the party calling the witness a right to cross-examine her, unless her evidence was of itself of such a nature as to make it appear that she was an unwilling witness.
By continuing, you agree to our Terms of Use and Privacy Policy.


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ART ALBUM. The Russian/Soviet Filmposter (Hardcover)
Title: The Russian Filmposter (Hardcover)
Author: by Snopkov (Author)
Cover: Hardcover, 366 pages
Publisher: Moscow, Kontakt-Kultura (2002)
Shipping: Worldwide free shipping
More than 300 posters about Russian/soviet movies in one book.1908-2001
Album RUSSIAN cinema poster is the most comprehensive summary illustrated edition devoted to the centuries-old history of Russian film posters, since its beginnings in Russia in the early XX century. The album includes 300 posters announcing the first appearance on cinema screens and the resumption of screenings of feature films and several documentary films created by outstanding masters of Russian and Soviet cinema of the XX century. Movies, the album received universal acclaim and was honored with many national and international awards and was included in the Golden Fund of world cinema. Most of the posters placed in the album, in a public illustrated magazines have played. The introductory article reveals the peculiarities of the history of Russian film posters. The album is supplied in the author index, illustrated list of works and index of films.
Addressed to a wide circle of readers and specialists in the field of art history, museology, advertising, marketing, artists, designers, filmmakers, workers of publishing houses, teachers and students of higher and secondary specialized educational institutions specializing in the field of advertising, graphic arts and design. For art lovers and collectors.


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A bit of everything in my life
Posted March 1, 2006on:
Woohoo, time for another entry! I wonder how come there was no one replying to my last entry, does this mean that no one reads my blog? Ok, nvm, I know a few who tells me they know what's going on with me from my blog anyway.
Listening to JJ's new album now, love the 1st song "ZHI DUI NI SHUO", so romantic especially with the Korean "I Love You" inside. Reminds me of Yong Ha. Hehe.. 7th song "AI QING YOGURT" reminds me of "DOU JIANG YOU TIAO" . Love the song, cute n meaningful. Last song on the album is English song called "Down", nice music but it suspiciously seems like originally a Mandarin song. So glad that he put the Channel U's song inside the album, I liked the catchy tune. JJ's my 2nd fav Chinese male artiste after my no.1 David Tao. Simply coz they are both sincere singer-songwriters with immense talent, are Christians and they are able to handle different genres of music especially my fav ballads n R&B. They are a couple of the rare people who I like all the songs in their albums.
Yest I went for 2 interviews. One was a 2nd interview at a sales n mktg com..found out from one of the trainers who brought me to a roadshow that there was no basic salary & therefore no CPF either. 100% commission-based. Seen those ppl who stand at the roads with broadband plans and Club rainbow charity? That's what I'll be doing if I take the job. Somehow that doesn't seem to agree with me. Prospects are good, yes..but risky wor. Wat happens if I can't get ppl to sign up? Eat myself?
The other was an admin job which reminds me of my work at my uncle's company except that I'll be the only one running the whole office if I took this up. The interviewer was a friendly lady but she sort of bothered me with all her opinions n good advice. You know I hate to be nagged. Even said my year at Chartered was wasted coz it did not add value to me. I was thinking, no it didn't. Juz becoz it didn't apply to that position doesn't mean it was wasted. I did experience what it was like to work in a corporate environment compared to a SME n made many friends n that's what count to me.
Give me a job I'll love, with good prospects n I'm able to excel in. That's all I ask , is that so difficult to find? Sigh….


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Lessons Learned from Investing $1 Billion (Stock vs ETF vs Mutual Fund Investing) - Part 1 of 2
Download the audio version and get the giveaway here: www.buildwealthcanada.ca/20
Today I'm thrilled to have Peter Hodson on the show who is the owner of 5i Research, the Canadian MoneySaver Magazine, and in his investment career, has managed over $1-billion dollars in assets.
How cool is that!
I've always wanted to have Peter on the show to pick his brain about investing best practices here in Canada, and see what he learned over his decades of professional investing.
Peter and his team have also been generous in providing Build Wealth Canada listeners with a special offer where you can get your investment questions answered, and learn more investment best practices by getting a free trial membership over at 5i Research.
Questions Covered:
Can you start by telling us your background, and your story from your days on Bay Street, to now running 5i Research and owning Canadian MoneySaver magazine?
In Canada it seems that investors fall into one of 5 main categories. They either:
Buy mutual funds
Buy indexes
Buy individual stocks for growth
Buy individual stocks for dividends
Buy a combination of the above.
Can you walk us through these options and how do we decide what type of investing is right for us?
Before we dive into more detail and talk about 5i, what are some key investing lessons that you've learned over the years that we can apply to our own investing lives?
Let's talk about 5i Research. For those Canadians that haven't heard of 5i, can you tell us more about what it is that you do, and how is 5i different?
You have a model portfolio for growth, and another for income on 5i. Can you explain the difference between the two and how do we know which one to follow based on our situation?
How do we choose between a growth vs a balanced portfolio?
How have these portfolios been performing compared to the index?
Why don't I just invest in indexes instead of following the 5i portfolio? Is it just because of the potential for higher returns or are there some other advantages or disadvantages? (ex. greater diversification among different industries)
What if I don't want to be researching and analyzing individual companies. Is 5i still a good fit for me? (i.e. can I just model your portfolio and not do anything else other than re-balance?). Or, do I need to be actively researching the companies you suggest after your initial recommendation to ensure that they are still a good fit?
Is your portfolio just for Canadian companies? If so, what sort of asset allocation do you suggest outside of Canada for diversification purposes?
Would you recommend using the 5i portfolio completely for the Canadian portion of our portfolio, and then use ETFs for international exposure?
ETFs that model a broad market index can now be purchased for free from certain discount brokerages here in Canada. If we are to follow the 5i portfolio, then we now have to deal with paying transaction costs every time that we purchase a stock. If somebody would like to invest a set percentage of their salary every month, what's the step-by-step process that they should take to do it most efficiently and to minimize fees while still being diversified (which is hard to do if you're only buying one company or two at a time)?
Would this workflow/strategy change depending on how much someone has to invest every month? What if we have a lump sum to invest?
Should I use my TFSA or RRSP for the 5i portfolio? What about using an unregistered account? Should I ever be using that instead? (i.e. preferential tax treatment on dividends). Does this vary based on whether I follow your income portfolio vs your growth portfolio?
Your portfolio has done really well. What if we're concerned that we've missed the boat and are now buying these companies when their prices are already at their peak (especially for those companies that have done really well)?
What are your thoughts on asset allocation between stocks and bonds? Do you recommend bonds? If not, what do you suggest?
You assign a letter grade to the stocks in your portfolio too. Is that more if we aren't following your portfolio and are just picking and choosing stocks?
For our ETF portion of the portfolio, what are your thoughts on more targeted ETFs like small cap ETFs vs just going for the broad market index? The more targeted ones can have higher fees so is it worth it since now your return has to try to offset those?


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Phoenix at Johnson Ferry
9 Sherwood Lane Marietta GA 30067
for a local advisor
Schedule a tour of The Phoenix at Johnson Ferry today and receive your complimentary guide to aid in choosing the best senior care facility for your loved one.
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*Prices quoted are monthly rental charges and are provided by the communities themselves. Actual prices may differ due to one-time fees, timing and care services required. Speak with your Senior Living Advisor to learn more.
Reviews of Phoenix at Johnson Ferry
- Poor
Meds not given on time. Staff had an attitude. Laundry mixed with other people's. Turnover of staff —it seems daily. 3 exec.directors in a few months. Etc.
- Poor
Meds not given on time. Staff had an attitude. Laundry mixed with other people's. Turnover of staff —it seems daily. 3 exec.directors in a few months. Etc.
- Don't go there.
Don't trust a word they say; only about 70% of whatever was spoken about at the initial sales pitch actually came to pass. They misrepresent everything! Don't go there.
- See all 24 community reviews
Community Details at Phoenix at Johnson Ferry
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If you become aware of any information that should be updated or noted, please contact A Place for Mom.


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The loss of Heskey after 55 minutes was the only blot on what was a superb defensive performance by the Latics against the Barclays Premier League leaders.
"He went for a challenge with William Gallas and he will go for a scan and we hope it is not too serious," said Bruce.
Copyright (c) PA Sport 2008, All Rights Reserved.


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Sylvia Watson, FSIA, Feng Shui
Consultant Columbus, Ohio
Feng Shui Articles
Nature's Lessons for a Career Change
By Sylvia Watson, FSII, FSIA and Connie Spruill, MA, FSIA © 2000
Feng shui can is a great career for those contemplating a career change.
First of all, life is about change and transitions. As this occurs, you grow and
gain wisdom. Even though you might be anxious to leave a particular field, it is
important to reflect on the benefits you received and the contributions you
made. Keep in mind that your present profession will always be invaluable to all
future endeavors; many of your skills honed over the years can be transferred to
your new career.
Not sure which option is right for you?
Still not sure which service is the best match? Contact Healing Environments with Feng Shui or call us at 614.402.5087. Please be aware that we do not employ salespeople, so there will be no sales pitch of any kind; simply a frank, friendly conversation about how we can work together.


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Student counselling cover letter
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text: Manchester is full of so many exciting things to do on your visit to the city and we can help to arrange some of these to your programme. Things To Do Old Trafford Stadium & Museum Tour Whether you're a Manchester United fan or not, a visit to the Museum & Tour Centre is a day to remember! Learn More Enquire Now Etihad Stadium Tour Explore MCFC heritage through the unique memorabilia and interactive self- guided displays. Learn More Enquire Now Premier League & Championship Matches Fantastic top Premier League and Championship fixtures during your stay. Tickets Limited. Learn More Enquire Now Professional Coaching Academy Professional coaching at the Platt Lane Academy is synonymous with developing outstanding young football talent. Learn More Enquire Now National Football Museum Explore the world's finest collection of football artefacts and archives. Free admission. Learn More Enquire Now The Trafford Centre Situated just 5 miles outside Manchester city centre visitors have the choice of 230 stores along 3 miles of granite and marble boulevards. Learn More Enquire Now Alton Towers Escape to Alton Towers Theme Park & Resort, perfect for thrillseekers. Learn More Enquire Now


text: The 2nd annual Snug Harbor Fishing Outing for the RPHS Hunt & Fish club was held last Saturday at Snug Harbor. There were 25 Reeths-Puffer kids in attendance at this outing that went from 10am-1pm. Prizes were given out to the biggest fish, smallest fish, and most caught. Congrats to Kaleb Visger on catching 8 fish. David Russell, Adam Hughey, and Austin Witham all tied catching a 16 inch bass. All together there were 5 brand new fishing poles, over 25 packages of soft baits, 12 Scentlok hats, and 6 tackle boxes given out as prizes. A big shout out goes to Snug Harbor Outfitters, Ray's Mini Mart, Johnson's Great Outdoors, Armstrong's, and Scentlok for supplying prizes and bait for this outing.


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This week, amid all the usual falsehoods and buffoonery, President Donald Trump struck a blow against US militarism and upended the proceedings of the "Group of Seven" industrialized countries. Take Trump out of it and… aren't these outcomes that the left has long wanted?
Can Trump occasionally be right for all the wrong reasons? And what's a lefty to do when this happens? Charles Mudede, Eli Sanders, and Rich Smith try to figure it out.
After that, Congresswoman Pramila Jayapal talks about what she saw inside an ICE detention center where migrant mothers seeking asylum in the US have been separated from their children. Jayapal shares the women's stories and talks about what listeners can do to end this inhumane practice.
Finally, another primary night! Charles talks about Wisconsin, Rich talks about Virginia, and Eli talks about South Carolina. Then Rich offers a quick take on the new, very funny Michelle Wolf series on Netflix. It's called "The Break."
Plus, as always, the music of Ahamefule J. Oluo.


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Making reading fun is the reason why Erik Stedman '20 started Canterbury's book club.
"I wanted reading to be something that wasn't stressful," he said. "Here you can just read a book without annotating it or worrying about taking a test about it."
Thirteen students, so far, are taking advantage of the opportunity.
"During the school year, you get unmotivated to read for fun, so book club is a way to keep me engaged to read for fun, and to experience new genres that I would not have read before," said Sabrina Capodicci '20.
Book club member's choose the books themselves by first presenting their recommendations to the club. From there Erik puts together a Google form where members vote on their first, second, and third choice. A synopsis of each recommended book is also attached so members can familiarize themselves with each book before voting.
"If you don't like the book chosen, you don't have to read it," said Erik. "And if you start the book, and don't like it, you don't have to finish it."
Book club meets the first Tuesday of every month during sit down lunch. So far, there are two tables dedicated to the book club. Mrs. O'Meara and Ms. Bailey sit at the two tables.
"The main reason that I created Book Club was because I wanted there to be a place where you could talk about books with other people, but also because I wanted there to be a way for people to discover new books that they may have never read before," said Erik.
The book chosen by the club for its first read is Hatchet by Gary Paulsen. Here is an excerpt from a review in Kirkus Books.
"A prototypical survival story: after an airplane crash, a 13-year-old city boy spends two months alone in the Canadian wilderness. In transit between his divorcing parents, Brian is the plane's only passenger. After casually showing him how to steer, the pilot has a heart attack and dies. In a breathtaking sequence, Brian maneuvers the plane for hours while he tries to think what to do, at last crashing as gently and levelly as he can manage into a lake. The plane sinks; all he has left is a hatchet, attached to his belt (Kirkus, 1987)."
If you would like to join the book club you can contact Erik Stedman '20.
"Hatchet by Gary Paulsen." Kirkus Review, Kirkus, 1 Sept. 1987,
www.kirkusreviews.com/book-reviews/gary-paulsen/hatchet/. Accessed 18 Oct.


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Exploring nature...
PUBLISHED: 20:00 07 June 2014
CHILDREN got to grips with nature during the spring half-term at a Sunshine And Puddles event, organised by North Somerset Children's Centre.
Zachary and Harrison making herb scent jars.
Families gathered at the Old Town Quarry in South Road, Weston, to enjoy arts and crafts, campfire cooking and games.


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Company Plan Software
Business plan software is something that typically gets overlooked
and isn't thought about, to be a need for some reason. In my
viewpoint, business strategy software is essential, it is not a high-end.
I am a big supporter of company preparation. When people ask me if
they require a company plan, my response is, "Absolutely!" You see,
starting a company without an organisation strategy is comparable to starting
college without a degree strategy. If you do not know where you are
going, you will not understand how to get there. You will squander your time
and your money if you are not following a strategy. It's truly that
So, you know you require a service plan, but what about business
plan software? For organisation preparation, there are truly three
alternatives: 1) crafting your own service plan from scratch; 2).
Hiring a business plan writer or business planning expert; or.
3) utilizing organisation strategy software application to write your own business strategy.
Each of these options has its own advantages and.
Composing your own organisation plan from scratch is definitely a.
possibility. Doing so offers you the flexibility to format and arrange.
The strategy in any way that you choose. On the other hand, doing.
Monetary projections, which are necessary for the purpose of.
Budgeting and financial planning can be tough to do without.
A service plan program, or a minimum of monetary projection.
Software application or spreadsheets.
Employing an organisation strategy author makes good sense …


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Child birth is something that is very special. One of the things that you are going to need to consider if you are pregnant is what type of assistance you would like to have during child birth. Chances are that you may want to consider a midwife. First, however, you must learn about some of the most important things regarding a midwife, such as what is a midwife and how you can find one.
What is a Midwife?
The most important thing that you may need to learn is what is a midwife. By definition, a midwife is a person who is trained to assist women during child birth. There are two different types of midwives, called direct entry midwives and certified nurse midwives. Using a midwife during child birth is known to be just as safe as using a doctor, as a person will need to meet a number of requirements in order to become a midwife.
What Do Midwives Do?
A midwife's job is to provide support to women throughout the entire duration of pregnancy, during labor, and during delivery. They do not offer pain medication to women during regular child births, as this is not something that they typically believe in. One of the main goals of midwives is to help women have safe births, without any type of complications. Many midwives even offer classes or information about safe deliveries.
Why Would a Person Need a Midwife?
If you are pregnant, it is important for you to choose someone to be present with you during the birth, whether it is a doctor or a midwife. Both are known to be equally safe and effective choices. Often, the amount of complications or medical interventions during child birth reduces when a midwife is used. This may be something that you will want to factor into your decision.
What Are the Requirements to Becoming a Midwife in the USA?
The requirements of becoming a midwife varies according to the type of midwife. A certified nurse midwife must have a bachelor's degree at the very minimum, must have completed nursing and midwifery training, and must get certified by passing both state and national exams. They typically work under the supervision of doctors and are often licensed in every state. Direct entry midwives do not always have a degree or certification. They typically get te job through apprenticeship or some other type of formal training. Many direct entry midwives work in homes or in non-hospital situations. However, some states do not allow them to work legally. Both certified nurse midwives and direct entry midwives can become certified by the North American Registry of Midwives as a certified professional midwife, after passing both written and hands on training examinations.
How Do You Hire a Certified Midwife in the USA?
In order to find a midwife in the United States, there are various places that can refer you to one. Aside from friends and family members, you can also ask your obstetrician-gynecologist or primary care physician to refer you to a midwife. Some midwives may work under the supervision of doctors or obstetrician-gynecologists, while others may come to you. Before you decide to hire a midwife, it is important to do a bit of research on their background. Finding out about their background, certifications, experience and anything else is very important to the overall success that you have with a midwife.