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Keeping Score
Going through my bookshelves, I came across a ten-year old document that I thought you might find interesting.
As part of a research project, I'd contacted Howe Sportsdata to ask if they had any official rules for scoring a professional ballgame. I was looking at official score sheets of minor league games, and found some symbols I'd never seen before. Howe sent me a document they distributed to all official scorers, which is a remarkable insight into the scorekeeping trade.
At the time, Howe was the official scoring service for minor league baseball, and collated data for Major League Baseball. Howe is no more, having been acquired by SportsTicker in December 1998. SportsTicker was just acquired by STATS Inc. on March 5. MLB brought all its stats services in-house a few years ago, and shortly thereafter took responsibility for collating minor league data.
One thing I found out from the Howe people is that there is no "official" way to score a ballgame. Most of us learned to score ballgames when we were children, but there are many systems and some people simply make up their own.
Here's what the Howe document had to say on the subject:
It is not a requirement, but we are trying to develop a standardized scorekeeping system throughout professional baseball. Toward that end, we are supplying you with 200 play-by-play scoresheets, good for 100 games. We understand longtime scorers have their own particular method that they will want to stay with, but otherwise scorers are strongly encouraged to stick as closely as possible to the uniform system outlined here.
These days, it's all done by computer. Go into any press box in affiliated baseball and you'll find them connected to a web page programmed by MLB Advanced Media (commonly known as BAM). It's all a standard interface. When entering lineups, the scorer actually enters for each player a unique ID number assigned by BAM.
But if you're a fan, you'll still do it the old-fashioned way, with a scorebook and a pencil.
The Howe document includes a sample scoresheet, the sheet for Game #7 of the 1960 World Series between the Yankees and Pirates. It's famous for Bill Mazeroski hitting a home run in the bottom of the 9th to give the Pirates the championship (long before it was called a "walk-off" homer.)
Here's a tidbit I bet you didn't know … No batter struck out in the game.
Click Here to view the Howe document. You need Adobe Acrobat Reader Version 7 or later to view the document.


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Nov 1, 2013
Rachel Sayers
For more than 50 years, Ohio University has partnered with United Appeal to harness the giving power of University employees. Starting Friday, Nov. 1, this year's "United 2 Give, United 2 Help" campaign will continue this long-standing partnership with United Appeal for Athens County to raise funds for those in need during the holiday season.
United Appeal is a charitable organization that helps to distribute funds to meet everyone's basic needs in Athens County. They accomplish this by allocating funds to a number of local charities, including the American Red Cross of Southeast Ohio, Athens County Habitat for Humanity, Athens County Food Pantry and other humanitarian organizations. A total of 16 agencies will be supported in the 2014 fundraising cycle. United Appeal also runs 2-1-1 Athens County – a free information service phone number.
"We've always been a good source of information for Ohio University employees," explained Pam Harvey, executive director of United Appeal. "We provide a way for people to give one-stop donations that benefit a number of different charities."
This year marks the University's 58th year participating in the annual fund drive, and has become something of a tradition for faculty and staff to give back during the holidays.
"Last year we were able to finally break the ten percent participation rate," said Harvey "To give as many people the opportunity to give as possible, whether it be a small amount or a large amount, is a wonderful thing, especially during the holiday season."
This year United Appeal has set a county-wide goal of raising $150,000, with the University's goal being $50,000. Pledge cards will be given out in University department mailboxes in the upcoming weeks, and donations can be made by payroll deduction, check or credit card. The campaign will run through December 24 and all are encouraged to give, no matter the amount.
"It's a way to get that holiday giving feeling right away," Harvey explained. "The money that we get is turned right around to make sure everyone in Athens has a wonderful holiday."

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Customize your JAMA Network experience by selecting one or more topics from the list below.
To determine the quantity of tobacco use in network television programming popular among US youth and to examine variation in tobacco depictions by TV Parental Guidelines system rating and television network.
A content analysis was conducted of broadcast network television programming popular among youth. Nielsen viewership rating data were used to identify a sample of top-rated television series for youth aged 12 to 17 years during the fall 2007 television season. Depictions of tobacco use per television episode were examined by TV Parental Guidelines rating and television network. χ2 testing was used to examine differences in proportions of tobacco depictions across television episode ratings and networks.
Data collection and analysis were conducted at the American Legacy Foundation (now known as Legacy).
Broadcast television viewers in 2007.
Main Outcome Measure
Tobacco use depictions on broadcast television were examined.
Forty percent of television episodes examined had at least 1 depiction of tobacco use. Of these depictions, 89% were of cigarettes. Among episodes rated TV-PG (ie, parental guidance suggested) (N = 73), 50% showed 1 or more incidents of cigarette use, in contrast to 26% of TV-14 (ie, parents strongly cautioned) episodes. The percentage of episodes with any tobacco use depictions was highest on the FOX network (44%; n = 32), followed closely by The CW (CBS–Warner Brothers) (41%; n = 30).
Substantial tobacco use was observed in television shows popular among youth. It is projected that almost 1 million youth were exposed to tobacco depictions through the programming examined. Tobacco use on television should be a cause for concern, particularly because of the high volume of television viewing among younger audiences.
In 2004, 78% of middle school students and 87% of high school students reported seeing actors using tobacco on television or in movies.1 Studies have documented the prevalence of tobacco imagery in movies,1-7 as well as the association between exposure to tobacco imagery in movies and initiation of smoking among youth.8-12 Based on these findings, the National Cancer Institute recently concluded that "the total weight of evidence. . . indicates a causal relationship between exposure to movie smoking depictions and youth smoking initiation."13(p11-12) In fact, Dalton et al12,13 estimate that exposure to smoking in movies accounts for approximately 52% of all smoking initiation. Because movies and television are not mutually exclusive media channels, the body of evidence pertaining to movies is relevant to television as well, particularly because most movies are shown on television after airing in cinemas. In addition, movie trailers (the advertisements used to promote movies playing in theaters) contain depictions of tobacco use and commonly air on television. A 2006 study14 found that 95% of youth aged 12 to 17 years in the United States were exposed to images of tobacco use on television in the context of a movie trailer during a 1-year period between August 2001 and July 2002. Exposure to these trailers has been shown to increase the attractiveness of smoking among youth who have experimented with cigarettes.15
Several studies16-20 have found a relationship between television viewing and smoking initiation. One study16 used longitudinal data to demonstrate that television viewing was associated with subsequent initiation; another study17 noted a quadratic relationship, with risk for initiation increasing markedly with more hours of television viewing. However, these studies do not document the number or prevalence of tobacco depictions in the televised content, nor do they make any claim regarding a causal association between televised tobacco depictions and youth smoking initiation. Other investigations have documented the prevalence of televised tobacco depictions within popular television series, such as The Simpsons,21,22 and across multiseries samples that are designed to represent popular television more broadly.23-27 The most recent data on US youth are from an Office of National Drug Control Policy study28 conducted in 1998. The study found tobacco depictions in 20% and tobacco-related dialogue in 23% of the sampled episodes, which were drawn from the 20 top-rated situation comedies or dramas popular among US youth aged 12 to 17 years. The study also found tobacco imagery in 6% of programs rated TV-G (defined as appropriate for a general audience), 20% of programs rated TV-PG (ie, parental guidance suggested), and 24% of programs rated TV-14 (ie, parents strongly cautioned).
The objective of this study was to provide current information about the potential exposure of US youth to tobacco imagery via television by quantifying the number of tobacco use depictions in a sample of television programs popular with youth aged 12 to 17 years during the fall 2007 season. We also compare the quantity of tobacco use across television rating categories and television networks.
The sample for this study included new television programming popular among an audience aged 12 to 17 years that aired on broadcast television during prime-time hours in the fall season of 2007 (September 21 through December 31, 2007). Prime time is defined as the part of day during which the greatest television viewership takes place,29 usually 8 to 11 PM. Programming that achieved a top 15 viewership rating among those aged 12 to 17 years according to Nielsen30 viewership data were selected for the sample. Sporting events, movies, awards programming, rerun episodes, and programming on cable television were excluded from the sample. Because of the Hollywood writers' strike in December 2007, two of these series (Family Guy and House) did not air new programming during the last month of the study period. The final study sample included 73 episodes representing the following 8 television series: American Dad, America's Next Top Model, Desperate Housewives, Family Guy, Gossip Girl, Heroes, House, and The Simpsons. All 73 episodes aired on 1 of the following 4 national broadcast television networks: ABC, FOX, NBC, or The CW (CBS–Warner Brothers). These 8 series represent an estimated 61.5 hours of television programming over a 14-week period.
The thumbs up! thumbs down! method for counting tobacco use depictions was used for this study.4,31,32 In brief, this approach consists of counting tobacco use in the following manner: (1) Each instance of on-screen tobacco depiction—regardless of whether the product is lit or how it is depicted in the episode (ie, in an ashtray, on a billboard, in a character's hands, etc)—is counted as a single incident. (2) When 2 characters are shown simultaneously smoking, it is counted as 2 incidents. (3) When a character who is smoking moves his or her cigarette, cigar, or pipe off screen and then back on, it is counted as 2 incidents. (4) When the camera focuses on a character using tobacco, focuses elsewhere, and then refocuses on the character using tobacco, it is counted as 2 incidents. An appearance of a carton of cigarettes is counted as 1 incident, with each visible cigarette in the carton counted as an additional incident.
Using the thumbs up! thumbs down! method, the following 3 forms of tobacco use were analyzed: cigarette, cigar, and pipe use. The number of tobacco incidents is presented as a cumulative count across the series, as well as dichotomously (no tobacco use vs ≥1 incidents of tobacco use per episode) to account for the potential of the thumbs up! thumbs down! approach to produce an overestimation of tobacco use.4 Dichotomous variables for tobacco use depictions were also created for cigarette and cigar use separately (any vs none).
All 73 episodes were analyzed by 2 trained research assistants. A third coder (D.S.) was used to resolve any discrepancies in incident counts. To assess overall agreement in tobacco content counts between the 2 coders, κ interrater reliability statistic was computed for each tobacco variable. Agreement for all forms of tobacco use was high (κ = 0.999, P < .001).
All television episodes are categorized according to their rating based on the TV Parental Guidelines system, a national public service classification established by the National Association of Broadcasters, the National Cable Television Association, and the Motion Picture Association of America to help guide parents regarding television content for their children.33 Rating categories, ordered from less to more restrictive, include the following: TV-Y, TV-Y7, TV-G, TV-PG, TV-14, and TV-Mature. All episodes in the study sample were rated TV-PG or TV-14. TV-PG is defined as the following: "Parental Guidance Suggested. This program contains material that parents may find unsuitable for younger children." In contrast, TV-14 is defined in the following manner: "Parents Strongly Cautioned: This program contains some material that many parents would find unsuitable for children under 14 years of age."34
Coarse or indecent language, sexual content, and portrayals of violence are the only factors considered in assigning TV Parental Guidelines.33 These ratings can be found on the television screen in real time for the first 15 seconds of each episode, as well as in TV Guide, Reader's Digest, and online. In addition, the Federal Communications Commission33 has made these ratings accessible via the V-chip technology.
The proportion of youth nationwide exposed to tobacco as a result of viewing the episodes examined in this analysis was estimated using 2 data sources. First, the estimated number of youth aged 12 to 17 years was obtained from the 2000 US Census.35 Second, Nielsen30 data estimating the number and percentage of youth watching the study episodes were obtained. A mean percentage was calculated by adding all the percentages and then dividing the aggregate sum by 73. Finally, the mean percentage of youth watching these 73 episodes was multiplied by the total number of individuals aged 12 to 17 years in the US population, resulting in the number of youth exposed to tobacco as a direct result of the programming examined in this study.
Statistical analysis was performed using commercially available software (SAS version 9.1; SAS Institute, Cary, North Carolina).36 Descriptive statistics include the median and interquartile range as measures of dispersion, as well as the absolute count of tobacco use depictions. Two-sided χ2 testing was used to compare TV Parental Guidelines categories and television networks by tobacco use (dichotomized as none vs ≥1 depictions), with episode as the unit of analysis. For contingency tables with at least 20% of cells containing fewer than 5 observations, Fisher exact test P values are reported.
Of 73 episodes examined, 40% (n = 29) included at least 1 depiction of tobacco use, 33% (n = 24) showed 1 or more depictions of cigarette use, and 8% (n = 6) demonstrated at least 1 depiction of cigar use. Most tobacco depictions were of cigarettes, amounting to 271 total incidents in 61.5 total hours of programming analyzed, for a mean of 4.4 incidents per hour (Table 1). Given the low incidence of pipe use, data are not shown for this product (data are available on request from author J.C.). Two of the series, Heroes and Gossip Girl, amounting to 20 episodes (or more than one-quarter of the study sample), did not include any depictions of tobacco use.
More than one-quarter (27% [n = 20]) of episodes examined in this study were rated TV-PG, in contrast to 73% (n = 53) of episodes rated TV-14 (Table 2). When comparing the proportion of episodes with any tobacco use, significantly more episodes rated TV-PG contained at least 1 tobacco depiction vs programming rated TV-14 (60% vs 32%, P = .03). While exactly half (50% [n = 10]) of episodes rated TV-PG had at least 1 cigarette depiction compared with just over one-quarter (26% [n = 14]) of episodes rated TV-14, this difference was not statistically significant (P = .09). In contrast, twice as many episodes rated TV-14 (9% [n = 5]) had 1 or more cigar depictions vs those rated TV-PG (5% [n = 14]), but this difference was also not statistically significant (P = .99). The median number of cigarette use depictions was 1 (interquartile range, 0-4) among episodes rated TV-PG compared with a median of 0 (interquartile range, 0-1) among episodes rated TV-14.
Most analyzed episodes aired on FOX (44% [n = 32]) network, followed by The CW (30% [n = 22]), NBC (15% [n = 11]), and ABC (11% [n = 8]) (Table 3). All episodes shown on NBC were rated TV-14, yet none contained tobacco depictions. In contrast, more than half of the programming on The CW contained tobacco use depictions; episodes on this network were evenly distributed across rating categories TV-PG and TV-14.
Significant differences were noted in the distribution of TV Parental Guidelines across television networks (P = .003). Television programming that aired on NBC was exclusively rated TV-14 (100%, n = 1), while most episodes on ABC (75%) and FOX (81%) were rated TV-14, and episodes on The CW were almost evenly distributed across the 2 ratings categories, with 45% rated TV-14 and 55% rated TV-PG.
The greatest proportion of episodes with at least 1 tobacco depiction was observed on FOX (44%), followed by The CW (41%), yet a higher absolute count of tobacco depictions was observed on The CW (n = 157), followed by FOX (n = 143). When comparing the proportions of episodes with 1 or more tobacco use depictions across all networks, significantly greater proportions of FOX and The CW episodes contained tobacco use (P = .004) than was observed in ABC and NBC programming. Nationally, the estimated number of youth aged 12 to 17 years who were exposed to tobacco use as a result of the television programming examined in this study was 940 000.
This is the first study in almost a decade that documents the incidence and proportion of tobacco depictions in a multiseries sample of television programming popular among US youth. Findings indicate that almost 40% of television programming most popular among youth aged 12 to 17 years includes tobacco depictions. Perhaps the most striking observation was that a higher proportion of tobacco use depictions was found among programs rated TV-PG compared with those rated TV-14, indicating that exposure to tobacco use may skew toward youth of younger ages, resulting in earlier exposure to this behavior. In fact, approximately half of all TV-PG–rated programming included some level of tobacco depictions. Estimates project that 940 000 (almost 1 million) youth were exposed to tobacco depictions on television during this single fall programming season.
This study included 1 reality (or allegedly unscripted) television series, America's Next Top Model. This popular series includes an episode in which there were 122 incidents of cigarette use. This incidence far exceeds that of any other single episode in this sample. As a result, analyses were performed with and without this outlier; tests of differences in the proportion of tobacco use depictions were consistent (data are available from author J.C.).
This study has several important limitations. Because the sample included only new and popular television programming and was reduced as a direct result of the writer's strike during the study interval, this study underestimates the total amount of exposure to tobacco depictions. In fact, Nielsen30 data indicate that the typical US youth aged 12 to 17 years watches on average 3 hours 20 minutes of television per day, or 200 minutes per day. Our study captured tobacco use during 61.5 hours (3690 minutes) of television during the 98-day study period, reflecting a mean of 38 minutes per day. If this estimate is taken as a fraction of the daily mean for a typical US teen, the programming examined in this study represents only 19%, or less than one-fifth, of a US youth's mean daily television consumption.37
Future research is warranted to better understand what, if any, effect exposure to televised tobacco depictions has on youth tobacco use initiation, particularly given the high level of television viewing among youth audiences. It is likely that multiple media channels provide exposure to tobacco depictions and, as such, may stimulate a similar effect. Ideally, samples should include a broad portfolio of programming popular among youth, with particular attention to cable and reality television programming.
Public health officials should urge television networks to eliminate all depictions of tobacco use in youth programming. Until then, TV Parental Guidelines should be adjusted so that programs featuring tobacco use are rated TV-MA (mature audience only).
Current TV Parental Guidelines do not consider any form of substance use, including tobacco, in determining a program rating.33 The strong evidence linking youth exposure to tobacco depictions in movies to initiation of smoking among youth should serve as a rationale for including tobacco use depictions as a criterion for rating programming for young audiences. However, only about one-quarter of parents report frequent use of TV Parental Guidelines ratings, and less than 10% of US households have made use of the V-chip, a tool that allows parents to identify and block television programming that they believe may be harmful to their children.37 Efforts to educate parents must be undertaken to increase the use of the TV Parental Guidelines rating system and the V-chip, in conjunction with modernizing the rating system to incorporate tobacco use depictions. Across the few programs that were sampled, almost 1 million youth were exposed to tobacco depictions on television over a single fall programming season. Public health practitioners and policy makers should discourage any tobacco depictions within youth programming. Further restrictions reducing youth exposure to tobacco use on television programming should be considered given the evidence linking smoking imagery in the media to initiation of youth smoking.
Correspondence: Jennifer Cullen, PhD, MPH, Legacy, 1724 Massachusetts Ave NW, Washington, DC 20036 (firstname.lastname@example.com).
Accepted for Publication: July 1, 2010.
Author Contributions:Study concept and design: Cullen, Sokol, Slawek, Vallone, and Healton. Acquisition of data: Sokol and Slawek. Analysis and interpretation of data: Cullen, Slawek, Allen, Vallone, and Healton. Drafting of the manuscript: Cullen, Sokol, Slawek, Allen, Vallone, and Healton. Critical revision of the manuscript for important intellectual content: Cullen, Sokol, Slawek, Allen, and Vallone. Statistical analysis: Cullen. Administrative, technical, and material support: Sokol, Slawek, Allen, Vallone, and Healton. Study supervision: Cullen, Slawek, Vallone, and Healton.
Financial Disclosure: None reported.
Cullen J, Sokol NA, Slawek D, Allen JA, Vallone D, Healton C. Depictions of Tobacco Use in 2007 Broadcast Television Programming Popular Among US Youth. Arch Pediatr Adolesc Med. 2011;165(2):147–151. doi:10.1001/archpediatrics.2010.276
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Congressional Showdown Over Debt Limit Could Happen Later Than Expected
Congressional Showdown Over Debt Limit Could Happen Later Than Expected
As they broke from a three-day retreat in Williamsburg, Va., House leaders offered President Obama and the Senate a temporary three month increase of the debt ceiling. David Welna talks to Robert Siegel about the proposal.
From NPR News, this is ALL THINGS CONSIDERED. I'm Audie Cornish.
And I'm Robert Siegel. A congressional showdown over the nation's debt limit may not happen as soon as expected. That's because House Republican leaders announced today that they are taking up legislation next week to extend the Treasury's borrowing limit for three more months. The surprise move comes at the end of the two-day House GOP retreat at a resort outside colonial Williamsburg in Virginia. NPR congressional correspondent David Welna is there and joins us now.
And David, Treasury Secretary Tim Geithner said the Treasury could run out of ways to pay the bills by mid-February unless the debt ceiling is raised. What does this extension, assuming it happens, what does it mean for that deadline and why the sudden turn from Republicans who seemed eager for a fight over the debt limit?
DAVID WELNA, BYLINE: Well, Robert, it would do away with that deadline, assuming such a measure does get passed by both chambers of Congress and signed into law by President Obama. If that happens, the big showdown over longer term raising of the debt ceiling, say, another two years, would be put off until April. I think what we're seeing here is a kind of a political blink, a recognition by House Republicans that while they may want a lot of concessions from Democrats, such as big spending cuts and entitlement reforms in exchange for raising the debt ceiling, they're not in a very good political position to get those concessions at a time when Democrats have just expanded their numbers in both the House and Senate and President Obama's won a second term.
I also think just not that many Republicans have the stomach to see what might happen should the country actually go into default. Republicans have already taken the blame for the debt ratings downgrade in the last debt ceiling debacle.
SIEGEL: Well, the last time that we had a showdown over the debt ceiling, it was August, 2011, and the Republicans were talking about a dollar for dollar - every dollar the debt ceiling was raised, a dollar's worth of spending had to be cut. Are they making the same kinds of demand for this short term extension?
WELNA: Not for this three month extension and that won some praise today from Senate Majority Leader Harry Reid, but Reid can't be happy about a demand House Republicans are making for this short term measure. They're going to include language that says until the Senate passes a budget, which it hasn't done for the past three years, the paychecks of all Senators will be withheld until a budget is passed.
Don't look for a lot of votes from Senate Democrats for that one. Also, an aide to Speaker John Boehner told me today that House Republicans won't agree to a longer term increase in the debt ceiling until a budget is passed. And April 15th, the day the short-term extension would run out is the same day a budget is due by law, so I would not rule out another Donnybrook over the debt ceiling around then.
SIEGEL: Now, there's another deadline looming out there, March 1st. On that date, the massive automatic spending cuts, which were delayed just last month, are set to kick in. Also, the government will run out of funding by the end of March, risking a possible shutdown. What's the Republican thinking, pushing the debt ceiling debate to the last of these big fights instead of the first?
WELNA: Well, I think it's mainly because Republicans realize they may not get much in exchange for raising the debt ceiling and so they think that they can - they have a stronger hand to play in these other fiscal fights that you just mentioned. They think that they can get concessions from President Obama both on spending cuts and possibly on entitlement reform. And those would be trophies for them to sort of brandish. If they're forced to fold in the debt ceiling fight in April, they could say we got something, at least.
SIEGEL: Okay, thank you, David. NPR congressional correspondent, David Welna.
Copyright © 2013 NPR. All rights reserved. Visit our website terms of use and permissions pages at www.npr.org for further information.
NPR transcripts are created on a rush deadline by Verb8tm, Inc., an NPR contractor, and produced using a proprietary transcription process developed with NPR. This text may not be in its final form and may be updated or revised in the future. Accuracy and availability may vary. The authoritative record of NPR's programming is the audio record.


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WOODINVILLE, WA -- LeMond Fitness and Life Fitness are caught up in court battles over a distribution dispute related to LeMond's RevMaster Pro group cycling bikes.
Life Fitness, owned by Brunswick Corp., Lake Forest, IL, has had the exclusive rights to sell LeMond RevMaster bikes in North America and some international markets since 2002. Some 75,000 RevMaster bikes have been sold in the United States, according to John Post, LeMond Fitness president.
In late May, Brunswick filed a civil lawsuit in Illinois seeking $3.9 million in damages related to the distribution of LeMond bikes, per published reports.
According to the suit, Life Fitness has received hundreds of customer complaints since early 2008 and has spent more than $225,000 on warranty and service work because of RevMaster problems. Life Fitness said it received complaints about the handle bars, seat and pedals of the bike. The company also said it has lost customers in the process.
The quality issues prompted Life Fitness to terminate its distribution agreement with LeMond last month, the company says.
LeMond denied the quality allegations and filed a lawsuit in federal court seeking more than $1 million in damages for early termination of the distribution agreement.
The company also issued a letter to its retailers on June 15. In the letter, Post told retailers that Life Fitness' allegations "are without merit" and were an "act of bad faith designed with no other purpose than to injure our reputation as a brand. I also want you to know that notwithstanding these events, we will continue to stand behind each and every one of our products."
Post told Club Industry's Fitness Business Pro that club owners may now order RevMaster and G-Force bikes, as well as parts and technical support, directly from LeMond Fitness. Online ordering is available on the LeMond Web site. To report problems with the bikes, club owners can contact LeMond directly by phone at 425-482-6773, ext. 109.
Life Fitness also said it will back the LeMond products it has sold.
"Club owners should contact Life Fitness—we stand behind all of our products and support any issues that will arise," says Stephanie Weiss, public relations representative for Life Fitness.


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Counting the money seems to grow more difficult every year both at home and in government. That�s why we hate to see an experienced hand at it decide to move on. THUMBS DOWN to news this week that Alamance County Finance Officer Amy Weaver will retire on Dec. 31 after serving the county for 30 years in various roles. Life�s not always smooth in the finance lane, but Weaver has guided the county through pretty darned well, we�d say. The next finance director, by the way, will be required to report directly to the Board of Commissioners, not through the county manager. Good luck there.
THUMBS UP to roots. In this case, we mean the success of the Future Farmers of America program at Southern Alamance High School. In our modern age, it�s good to see renewed interest in agriculture, what used to rule our culture many decades ago. The program at SHS has about 400 students taking agriculture classes like horticulture, agricultural mechanics or agriscience. About 350 of those students are also FFA members. Last year Southern�s FFA won first place in five out of five categories at the state FFA convention. It was a first for Southern or any other school. FFA students also take care of the grounds and turf on campus, making Southern one of the best-looking campuses around.
THUMBS DOWN to the ravages of age. We�re speaking here about Burlington�s Walter B. Ellis American Legion Post 63. The Willowbrook Drive site has been a local fixture since 1924, when World War I veterans built the stone and brick building. Age and deterioration have taken their toll. Rainwater regularly floods the lounge. The building�s foundation needs extensive work and, after years of water damage, the kitchen and bathrooms need to be replaced. Post leaders have been able to secure loans to cover some of the $35,000 costs but are turning to the community for help with the rest. If you feel moved to help out these guys and gals who served their country in defense of us all, contact (336) 226-9273. We recommend it.
THUMBS UP to the more than 200 athletes and 75 coaches who are in Burlington this weekend for the Special Olympics State Bocce Tournament. This is the first year the city has hosted it. Athletes have trained for a minimum of eight weeks at the local level and competed in a mandatory qualifier prior to moving on to this state-level competition. Games continue today until 5 p.m. at the Burlington Tennis Center, 1402 Overbrook Road, at City Park.
THUMBS UPto Alamance-Burlington Schools Teacher of the Year, DeAnna Foust-Platt, who is a finalist for regional teacher of the year. Foust-Platt is one of two finalists for 2013 Piedmont Triad/Central Region Teacher of the Year. She spent the past two and a half years working in ABSS alternative schools, first Sellars-Gunn and now teaches middle grades reading and English language arts at Ray Street Academy in Graham. She�ll find out in December if she has been chosen to represent the Piedmont Triad/Central Region and advance in the 2013 North Carolina Teacher of the Year competition.
THUMBS DOWN to the impending closing of B. Christopher�s after close to 15 years of doing business locally. The Burlington fine-dining restaurant is relocating to downtown Greensboro by January. Owner Chris Russell said he was undecided about whether to relocate B�s Bistro and Micro Lounge, which he also owns. Locally owned businesses, you hate to lose even one.
And THUMBS UP to the many hats the Salvation Army is donning these days as it deals with people in need and the coming of Thanksgiving and Christmas. The Army is still in need of food to help restock its pantry, hit particularly hard since the sudden closure of Loaves & Fishes Food Ministry. It is also taking applications for its Angel Tree program, which provides Christmas assistance to families with children who might otherwise not receive holiday gifts. For more information, call the Salvation Army at 336-227-5529.
Thanks for doing so.


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Harvard University President Drew Faust has ordered a comprehensive review of the university's email privacy polices amid disclosures that a secret search of some deans' email accounts by administrators was broader than originally acknowledged.
Speaking at a meeting with Harvard's Faculty of Arts and Sciences (FAS) on Tuesday, Faust expressed concern over the university's "highly inadequate" institutional policies and processes for protecting email privacy.
"We have multiple policies across the university that vary across schools, with some faculties lacking any explicit policies at all," Faust said in remarks posted verbatim by Harvard Magazine.
Calling the lack of email policies an "institutional failure," Faust said she would create a task force to develop recommendations on university-wide policies and guidelines for email. Those recommendations will be made available for community discussion and university consideration by the end of the fall term.
Faust's remarks come a few weeks after the Boston Globe detailed how university administrators had secretly searched the email accounts of 16 resident deans at Harvard. The university was looking for the source of a leak about a cheating scandal, the Globe reported.
Harvard acknowledged the search, but maintained it was done in an extremely limited manner and only to identify an individual who shared a confidential email with an unauthorized person. The email, which contained advice on how to counsel students accused of cheating, was shared with the Harvard Crimson student newspaper and later picked up by the Globe. Harvard administrators said they decided to conduct a search out of concerns for the privacy of students involved in the cheating scandal.
Harvard officials admitted they made a mistake in not informing the deans about the search, either before or after it took place. The university, however, insisted that it had not actually opened any emails or searched their contents. Instead, IT administrators only conducted an automated subject line search of each dean's administrative email accounts to see if they could identify the source of the leak. The university also stressed that the subject-line search only involved administrative email accounts, not a separate Harvard email account that each dean maintains for personal use.
At Tuesday's meeting, Harvard Dean Evelyn Hammond noted that two additional searches had taken place that were not previously disclosed. After the initial search identified the resident dean responsible for forwarding the email, Hammond said she authorized another search to look specifically for correspondence between that individual and two student reporters from the Crimson.
In addition, Hammond said she also authorized a search of the same dean's personal email account for correspondence with the reporters. In both cases, the search involved only the subject lines and not the actual content of the emails, she said in comments posted on Harvard Magazine. She apologized for not informing her peers or the deans about the searches, but insisted that her actions were driven purely by concerns over student privacy.
The incident has proved to be embarrassing for Harvard. Several faculty members have faulted the university for not informing deans about the searches and said they fear the incident could erode trust between administrators, faculty members and staff.
Acknowledging those concerns, Faust said Tuesday that she has also asked a leading Boston lawyer from outside Harvard to conduct a full investigation into how the searches were conducted and to verify that the information provided so far is a full and accurate description of what actually happened.
Jaikumar Vijayan covers data security and privacy issues, financial services security and e-voting for Computerworld. Follow Jaikumar on Twitter at @jaivijayan or subscribe to Jaikumar's RSS feed. His e-mail address is firstname.lastname@example.com.
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Jul 16 @ 6:30 pm – 9:00 pm
Join us in Chicago's Fulton Market area in the historic, Morgan Manufacturing building as we bring our signature grape to the windy city. This elegant and industrial urban space will be home to 60 renowned Willamette Valley Wineries. Owners and winemakers will be on hand offering a specially curated wine list, including library and current releases, perfectly paired with wine-friendly small bites.
Morgan Manufacturing | 401 N Morgan Street, Chicago, 60642
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Saitek is the third company to release one of these keyboard game controllers. The company must have lacked research skills when developing its Pro Gamer Command Unit (PGCU) because this product has the same problems of its predecessors. There are 21 keys total, including an awkwardly-placed "shift" key that gives a second function to all of the other keys, and a toggle switch that proves to be useless in most games. Stiff keys, semi-awkward design and an expensive price tag ($68) are severely hindering the PGCU.
Saitek Pro Gamer Command Unit [TrustedReviews]


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"The book project Shoe Fleur: A Footwear Fantasy began with a picture of a leaf I had taken for a client" says Michel. "The leaf was turned upside down and I remember saying out loud to no one in particular, "that leaf looks like a shoe". After a move here and a twist there, Michel had created his first shoe fleur, appropriately named, La Première. Each morning for a year Michel went to the flower market and came home with the blooms that inspired him. "The flowers actually spoke to me...and by sculpting these accessories from individual botanicals I was speaking back". Whether you're shoe-obsessed, fashion-forward, flower-powered of just an imaging aficionado, Shoe Fleur just may stimulate and inspire a few fantasies of your own.
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Subscribe To UPDATED: Clash Of The Titans 2 And Deadpool Still Don't Have Directors, But They're Getting Closer Updates
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Way back in June we got ourselves excited about the news that Jonathan Liebesman may direct Clash of the Titans 2, and right around the same time the rumors were swirling that Robert Rodriguez had been offered Deadpool, the Ryan Reynolds-starring spinoff from X-Men Origins: Wolverine. Here were are three months later and neither deal has been confirmed, but Deadline Hollywood is chiming in to swear it's too soon to give up hope.
[UPDATE: THR now says Jonathan Liebesman has just signed a deal to direct Clash of the Titans 2.]
Things are looking a little worse for Liebesman and Warner Bros. as they try to hammer out a Clash of the Titans deal, since apparently "they are far apart on money." But Rodriguez himself went on the record to explain that, with Deadpool, the delay is more about schedules than money. Rodriguez has read and like the Deadpool script, but he's also committed to making Spy Kids 4 for whatever reason:
"We haven't really gotten into the discussion, but they are trying to make a certain small window that's going to be tough because of Spy Kids. If they push it back, it would be a lot better for me."
The bigger problem seems to be Reynolds' schedule, since he's committed to half a dozen other projects including the cop comedy announced this morning. Reynolds is a requirement for Deadpool and Rodriguez is not, so if you're placing bets on which one will have his schedule accommodated, I would assume Fox will let Rodriguez keep the Spy Kids and shove off.
So there's your update for the day: nothing has changed, the same people are still in the running, and nothing is official. Sorry if we got your hopes up.


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Former Republican presidential candidate and Senator Rick Santorum came out in strong opposition of Chuck Hagel's nomination as Secretary of Defense, suggesting that Iran could acquire a nuclear bomb if he holds the position.
Santorum's PAC, Patriot Voices, sent an email to supporters this morning with the subject line "Iran has a nuclear bomb." Santorum suggested in the email that it could be the case with Hagel as Defense Secretary.
Santorum said that Patriot Voices will be launching a national media campaign with ads on television and radio in the hopes of blocking Hagel's confirmation.
Here's Santorum's full email:
"Iran has a nuclear bomb"
This could be the horrific headline not too far in the future if we don't stop the nomination of Chuck Hagel as Secretary of Defense.
I strongly oppose President Obama's nomination of former Senator Chuck Hagel for Secretary of Defense because his confirmation would send a dangerous signal to Iran and other radical Islamic elements which would make our country and our allies less secure. Not only did Senator Hagel tip off the Iranians that he would not use strength to prevent them from obtaining nuclear weapons, he disrespects our strongest ally in the middle east, Israel. Time after time, Sen. Hagel has sought to distance the United States from Israel and refused to stop efforts to end terrorist attacks on Israel.
But we shouldn't be surprised that President Obama would nominate someone like Senator Hagel to this important position. After all, it was President Obama who whispered his "flexibility" to Russian dictators.
That's why I am announcing our campaign to stop Chuck Hagel from becoming Secretary of Defense.
Defeating Senator Hagel's nomination will not be easy, but as we learned with our efforts to defeat the United Nations Convention on the Rights of Persons with Disabilities (CRPD) treaty, it is a battle worth taking on. Just last month, we won our fight to stop CRPD, and for the safety and security of our nation, I intend to win the fight to stop the nomination of Chuck Hagel as Defense Secretary.


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Mr. Destructoid is in everything these days, including your mom!
Destructoid's time is running out in the first free TMS challenge for Ms. Splosion Man. The challenge comes to an end on July 31, just a few days from now. The top three times on the Mr. Destructoid challenge will win some Ms. Splosion Man and Destructoid goodies like figures, limited edition bobbleheads, posters and shirts.
Here are the top five users and times on the leaderboards as of this posting:
What's your best time? Think you can make it in the top three?
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Saturday, January 14, 2012
Game 12: Verizon Center
Sixers 103, Wizards 90
WASHINGTON — The first time I went to an NBA game was in March of 1980 in a late-season game between the two-time defending Eastern Conference champion Washington Bullets and the lowly Detroit Pistons. The game was played at the Bullets' arena in Landover, Md., called the Capitol Centre.
As far as suburban arenas go, there was nothing too unique about the Cap Centre aside from the fact that there were no levels in the seating area. It was like a high-school gym with bleachers ringing the playing surface.
Granted, it would have been a pretty big high-school gym since the Cap Centre had a capacity for more than 18,000 people, but a high-school gym nonetheless.
There wasn't anywhere close to 18,000 folks in the Cap Centre on a sunny Sunday in March of 1980. In fact, I got the sense that my dad wasn't too excited about going to see the Bullets' game even with the free tickets. I was insistent, though. I always was when it came to going to games.
Anyway, we saw a few Hall of Famers that afternoon. Elvin Hayes, the Bullets' high-scoring forward was 34 and winding down his NBA career and Wes Unseld, the rebounding machine, was in his next-to-last season in the league. The Bullets also had All-Stars Bobby Dandridge and Phil Chenier, as well as standouts like Kevin Grevey, Greg Ballard, Mitch Kupchak and a guy called "Super" John Williamson.
Detroit had Hall of Famer Bob McAdoo and had just fired a little-known coach named Dick Vitale. When the gig with the Pistons didn't work out, Vitale gave broadcasting a try.
With all that talent on the floor, it was the smallest dude out there that stole the show.
Point guard Kevin Porter had 24 assists that afternoon, which at the time was the fourth-most in a game in NBA history. In a game two years earlier, Porter got the record of 29 assists in a game, which he held until the 1990-91 season when Scott Skiles got 30.
In all the years and all the games that followed, I never saw anyone come anywhere close to matching Porter's 24-assists game. And I have seen a lot of games. Hell, I was even at the game where Willie Burton scored 53 points to set the single-game scoring record at the Spectrum, but no one ever has come close to emulating Porter in that very first game I attended. Actually, 24 assists in a game has been surpassed just nine times by seven players in the 32 years since my first game and the last of those came in 1996.
Chances are I saw something I'll never see again that day at the Cap Centre.


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Can I Have Surgery After Radiation?
Dear OncoLink "Ask The Experts,"
I have heard that if I choose radiation therapy for prostate cancer treatment that I could not have surgery later if the cancer recurs. Why not?
Alan J. Wein, MD, Professor and Chair of the Division of Urology at the University of Pennsylvania School of Medicine, responds:
You can have surgery after radiation therapy. The risks however, such as urinary incontinence, erection, rectal injury are very much higher and the actual cure rates (meaning no disease present at 10 to 15 years after surgery) are uncertain.
Daniel Eun MD ?Director of Robotic and Minimally Invasive Urologic Oncology and Reconstruction at PENN Urology at Pennsylvania Hospital, responds:
One of the most common questions posed to urologists surrounds the concept of limiting treatment options if one chooses radiation. It is true that radiation therapy can be administered to patients with either high-risk features at prostatectomy or detectable PSA following surgery. The question of surgery after radiation therapy is a bit more complicated. There are certainly centers that will perform surgery after radiation therapy; however, the morbidity (side-effects) associated with salvage prostatectomy (surgery after radiation) is significant, particularly with regard to erectlie dysfunction and urinary continence. Cryotherapy (freezing the prostate) remains an option for those patients who undergo radiation therapy who are thought to have local failure.
This question and answer was part of the OncoLink Brown Bag Chat Series. See the full transcript of Prostate cancer treatment: where are we now?


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We're glad we wore our deodorant on Saturday, such was the sweat factor at The Standard Hotel, where Purple Magazine double teamed it with Zac Posen for one of Fashion Week's most perspiration-inducing parties. Having enjoyed another "P" before in the form of Prabal Gurung's dance-off, our Belvedere soaked brains (and spilled-on pant leg) needed a minute to adjust to a crush of front-row girls and guys spilling across both the Boom Boom Room and Le Bain. Everywhere you looked Olivier Zahm was posing for pictures, cigarette in one hand, bottle of vodka in another, while Jared Leto's poncho never quite left our field of vision. Add a leather-daddied up Cator Sparks and a gyrating Paz de la Huerta, and raunchy glam had officially arrived. We managed to stay relatively dry by the pool table, where Lady Gaga's "Born This Way" lyrics suddenly seemed to make a lot more sense.
All The Best Fashion Moments From The Orange Is The New Black...
The groundbreaking Netflix series Orange Is The New Black may officially be coming to an end with the seventh season now streaming, but don't worry,


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Reversible Showerproof Down-filled Hooded Gilet
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- A showerproof gilet in reversible contrast colours, down-filled and hooded for added warmth.
- Outer: 100% polyester
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text: Rep. Gabrielle Giffords is still undergoing physical and speech therapy in Houston, but on Sunday she'll return to Arizona to participate in events marking the one year anniversary of the shooting that left her wounded and six people dead. Giffords' husband, Mark Kelly, plans to speak during a vigil at the University of Arizona. Giffords won't do any interviews while in Tucson and isn't expected to speak at the events, but the fact that she's able to attend already says a lot.


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A New Hitting Coach and a Medicine Ball Rejuvenate a Beleaguered Dunn
Poor Adam Dunn.
It now comes to light that he may not have had to endure his historically-awful 2011 season if Jeff Manto was the hitting coach.
You see, Dunn spoke yesterday of Manto's unconventional method of having the slugger swinging a bat with a medicine ball–yes, a medicine ball–between his legs to help keep him from lunging which preserves his overall balance.
So far, at least, the results are clear. Dunn's been a different hitter as of late, coming up with clutch hits and going the other way to boot. Last night, he drove in five runs in the 7-3 Sox victory over the Mariners with an opposite field, run-scoring double and a pair of homers, one a towering three-run shot.
After the first 13 games of the season he's now got three homers, 12 RBIs, a .265 batting average (more than 100 points higher than he finished last year), a .368 on-base percentage and .940 OPS.
The strikeouts (22) are still there and, let's face it, they always wil be for a hitter of this ilk. But I think that you'll agree that we can live with that, if we get those home runs and run-scoring doubles.


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Canaccord Genuity Wealth Management Investment Advisors are driven by core company values and recognize that building lasting relationships is key to delivering results to our clients and community.
1. We put our clients first.
We develop deep trust with our clients through detailed consultation, appropriate investment ideas and value-added services.
2. A good reputation is our most valued currency.
Integrity and respect for client confidentiality are the basis of all our relationships.
3. Ideas are the engine of our business.
Our originality in the generation of quality ideas positions us ahead of the competition globally.
4. We are an entrepreneurial, hard-working culture.
We believe that highly qualified, motivated professionals working together in an entrepreneurial environment results in superior client service and shareholder value.
5. We strive for client intimacy.
The more detailed our understanding of our clients' needs and objectives, the better positioned we are to meet them.
6. We are dedicated to creating exemplary shareholder value.
We are committed to aligning the interests of our people with fellow Canaccord Genuity shareholders through share ownership. We believe that ownership motivates the ideas and efforts that lead to value creation.
7. To us there are no foreign markets.TM
Our clients benefit from our truly global perspective. We deliver insightful, actionable ideas from both local and international markets through our continued pursuit and evaluation of global opportunities.
Rodney Blake


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- Pernix Therapeutics is pleased to provide its users with information provided by and access to Managed Markets Insight & Technology (MMIT), LLC's Formulary Compass™ database. Pernix Therapeutics does not review the information content, accuracy, completeness, or compliance with any applicable statute, rule, or regulation
- Source: Managed Markets Insight & Technology (MMIT), LLC and/or publicly available websites, as of 8/25/2019, and is subject to change without notice by a health plan or state. Please contact the plan or state for the most current information
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- This is intended for provider communication only. This information is not a guarantee of coverage or payment (partial or full). Actual benefits are determined by each plan administrator in accordance with their respective policy and procedures
- Formulary information in this document does not establish clinical comparability of products and should not be seen as making any claim regarding efficacy or safety
- This list may not be an exhaustive list of all plans in your area
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- Pernix Therapeutics does not endorse any particular plan. Other product and company names mentioned herein are the trademarks of their respective owners
WARNING: ADDICTION, ABUSE, AND MISUSE; LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; NEONATAL OPIOID WITHDRAWAL SYNDROME; CYTOCHROME P450 3A4 INTERACTION; RISKS FROM CONCOMITANT USE WITH BENZODIAZEPINES AND OTHER CNS DEPRESSANTS; and INTERACTION WITH ALCOHOL;Addiction, Abuse, and Misuse
ZOHYDRO ER exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk prior to prescribing ZOHYDRO ER and monitor all patients regularly for the development of these behaviors and conditions.Life-Threatening Respiratory Depression
Serious, life-threatening, or fatal respiratory depression may occur with use of ZOHYDRO ER. Monitor for respiratory depression, especially during initiation of ZOHYDRO ER or following a dose increase. Instruct patients to swallow ZOHYDRO ER capsules whole; crushing, chewing, or dissolving ZOHYDRO ER capsules can cause rapid release and absorption of a potentially fatal dose of hydrocodone.Accidental Ingestion
Accidental ingestion of even one dose of ZOHYDRO ER, especially by children, can result in a fatal overdose of hydrocodone.Neonatal Opioid Withdrawal Syndrome
Prolonged use of ZOHYDRO ER during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.Cytochrome P450 3A4 Interaction
The concomitant use of ZOHYDRO ER with all cytochrome P450 3A4 inhibitors may result in an increase in hydrocodone plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in hydrocodone plasma concentration. Monitor patients receiving ZOHYDRO ER and any CYP3A4 inhibitor or inducer.Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants
Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.
- Reserve concomitant prescribing of ZOHYDRO ER and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate.
- Limit dosages and durations to the minimum required.
- Follow patients for signs and symptoms of respiratory depression and sedation.
Instruct patients not to consume alcoholic beverages or use prescription or non-prescription products that contain alcohol while taking ZOHYDRO ER. The co-ingestion of alcohol with ZOHYDRO ER may result in increased plasma levels and a potentially fatal overdose of hydrocodone.
ZOHYDRO® ER (hydrocodone bitartrate) is indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.
- Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations, reserve ZOHYDRO ER for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.
- ZOHYDRO ER is not indicated as an as-needed (prn) analgesic.
- Significant respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment
- Known or suspected gastrointestinal obstruction, including paralytic ileus
- Hypersensitivity to hydrocodone or to any other components of ZOHYDRO ER
Addiction, Abuse, and Misuse
ZOHYDRO ER contains hydrocodone, a Schedule II controlled substance. As an opioid, ZOHYDRO ER exposes users to the risks of addiction, abuse, and misuse. Because extended-release products such as ZOHYDRO ER deliver the opioid over an extended period of time, there is a greater risk for overdose and death due to the larger amount of hydrocodone present.
Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed ZOHYDRO ER. Addiction can occur at recommended doses and if the drug is misused or abused.
Assess each patient's risk for opioid addiction, abuse, or misuse prior to prescribing ZOHYDRO ER, and monitor all patients receiving ZOHYDRO ER for the development of these behaviors and conditions. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol addiction or abuse) or mental illness (e.g., major depression). The potential for these risks should not, however, prevent the prescribing of ZOHYDRO ER for the proper management of pain in any given patient. Patients at increased risk may be prescribed opioids such as ZOHYDRO ER, but use in such patients necessitates intensive counseling about the risks and proper use of ZOHYDRO ER along with intensive monitoring for signs of addiction, abuse, and misuse.
Abuse or misuse of ZOHYDRO ER by crushing, chewing, snorting, or injecting the dissolved product will result in the uncontrolled delivery of the hydrocodone and can result in overdose and death.
Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing ZOHYDRO ER. Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity and advising the patient on the proper disposal of unused drug. Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product.Life-Threatening Respiratory Depression
Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used as recommended. Respiratory depression, if not immediately recognized and treated, may lead to respiratory arrest and death. Management of respiratory depression may include close observation, supportive measures, and use of opioid antagonists, depending on the patient's clinical status. Carbon dioxide (CO2) retention from opioid-induced respiratory depression can exacerbate the sedating effects of opioids.
While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of ZOHYDRO ER, the risk is greatest during the initiation of therapy or following a dosage increase. Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy with and following dosage increases of ZOHYDRO ER.
To reduce the risk of respiratory depression, proper dosing and titration of ZOHYDRO ER are essential. Overestimating the ZOHYDRO ER dose when converting patients from another opioid product can result in fatal overdose with the first dose.
Accidental ingestion of even one dose of ZOHYDRO ER, especially by children, can result in respiratory depression and death due to an overdose of hydrocodone.Neonatal Opioid Withdrawal Syndrome
Prolonged use of ZOHYDRO ER during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. Observe newborns for signs of neonatal opioid withdrawal syndrome and mange accordingly. Advise pregnant women using opioids for a prolonged period of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.Risks from Concomitant Use or Discontinuation of Cytochrome P450 3A4 Inhibitors and Inducers
Concomitant use of ZOHYDRO ER with a CYP3A4 inhibitor, such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritonavir), may increase plasma concentrations of hydrocodone and prolong opioid adverse reactions, which may cause potentially fatal respiratory depression, particularly when an inhibitor is added after a stable dose of ZOHYDRO ER is achieved. Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in ZOHYDRO ER-treated patients may increase hydrocodone plasma concentrations and prolong opioid adverse reactions. When using ZOHYDRO ER with CYP3A4 inhibitors or discontinuing CYP3A4 inducers in ZOHYDRO ER-treated patients, monitor patients closely at frequent intervals and consider dosage reduction of ZOHYDRO ER until stable drug effects are achieved.
Concomitant use of ZOHYDRO ER with CYP3A4 inducers or discontinuation of an CYP3A4 inhibitor could decrease hydrocodone plasma concentrations, decrease opioid efficacy or, possibly, lead to a withdrawal syndrome in a patient who had developed physical dependence to hydrocodone. When using ZOHYDRO ER with CYP3A4 inducers or discontinuing CYP3A4 inhibitors, monitor patients closely at frequent intervals and consider increasing the opioid dosage if needed to maintain adequate analgesia or if symptoms of opioid withdrawal occur.Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants
Profound sedation, respiratory depression, coma, and death may result from the concomitant use of ZOHYDRO ER with benzodiazepines or other CNS depressants (e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, other opioids, alcohol). Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.
Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioid analgesics alone. Because of similar pharmacological properties, it is reasonable to expect similar risk with the concomitant use of other CNS depressant drugs with opioid analgesics.
If the decision is made to prescribe a benzodiazepine or other CNS depressant concomitantly with an opioid analgesic, prescribe the lowest effective dosages and minimum duration of concomitant use. In patients already receiving an opioid analgesic, prescribe a lower initial dose of the benzodiazepine or other CNS depressant than indicated in the absence of an opioid, and titrate based on clinical response. If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe a lower initial dose of the opioid analgesic, and titrate based on clinical response. Follow patients closely for signs and symptoms of respiratory depression and sedation.
Advise both patients and caregivers about the risks of respiratory depression and sedation when ZOHYDRO ER is used with benzodiazepines or other CNS depressants (including alcohol and illicit drugs). Advise patients not to drive or operate heavy machinery until the effects of concomitant use of the benzodiazepine or other CNS depressant have been determined. Screen patients for risk of substance use disorders, including opioid abuse and misuse, and warn them of the risk of overdose and death associated with the use of additional CNS depressants including alcohol and illicit drugs.
Patients must not consume alcoholic beverages, or prescription or non-prescription products containing alcohol, while on ZOHYDRO ER therapy. The co-ingestion of alcohol with ZOHYDRO ER may result in increased plasma levels and a potentially fatal overdose of hydrocodone.Life-Threatening Respiratory Depression in Patients with Chronic Pulmonary Disease or in Elderly, Cachectic, or Debilitated Patients.
The use of ZOHYDRO ER in patients with acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment is contraindicated.
Patients with Chronic Pulmonary Disease: ZOHYDRO ER-treated patients with significant chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosages of ZOHYDRO ER.
Elderly, Cachectic, or Debilitated Patients: Life-threatening respiratory depression is more likely to occur in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics or altered clearance compared to younger, healthier patients.
Monitor such patients closely, particular when initiating and titrating ZOHYDRO ER and when ZOHYDRO ER is given concomitantly with other drugs that depress respiration. Alternatively, consider the use of non-opioid analgesics in these patients.Adrenal Insufficiency
Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use. Presentation of adrenal insufficiency may include non-specific symptoms and signs including nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure. If adrenal insufficiency is suspected, confirm diagnosis with diagnostic testing as soon as possible. If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. Wean the patient off of the opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers. Other opioids may be tried as some cases reported use of a different opioid without recurrence of adrenal insufficiency. The information available does not identify any particular opioid as being more likely to be associated with adrenal insufficiency.Severe Hypotension
ZOHYDRO ER may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients. There is an added risk in patients whose ability to maintain blood pressure has already been compromised by a reduced blood volume, or after concurrent administration of certain CNS depressant drugs (e.g., phenothiazines or general anesthetics). Monitor these patients for signs of hypotension after initiating or titrating the dosage of ZOHYDRO ER. In patients with circulatory shock, ZOHYDRO ER may cause vasodilation that can further reduce cardiac output and blood pressure. Avoid the use of ZOHYDRO ER in patients with circulatory shock.Risks of Use in Patients with Increased Intracranial Pressure, Brain Tumors, Head Injury, or Impaired Consciousness
In patients who may be susceptible to the intracranial effects of CO2 retention (e.g., those with evidence of increased intracranial pressure or brain tumors), ZOHYDRO ER may reduce respiratory drive, and the resultant CO2 retention can further increase intracranial pressure. Monitor such patients for signs of sedation and respiratory depression, particularly when initiating therapy with ZOHYDRO ER.
Opioids may also obscure the clinical course in a patient with a head injury. Avoid the use of ZOHYDRO ER in patients with impaired consciousness or coma.Risks of Use in Patients with Gastrointestinal Conditions
ZOHYDRO ER is contraindicated in patients with known or suspected gastrointestinal obstruction, including paralytic ileus. Hydrocodone in ZOHYDRO ER may cause spasm of the sphincter of Oddi. Opioids may cause increases in serum amylase. Monitor patients with biliary tract disease, including acute pancreatitis, for worsening of symptoms.Increased Risk of Seizures in Patients with Seizure Disorders
The hydrocodone in ZOHYDRO ER may increase the frequency of seizures in patients with seizure disorders, and may increase the risk occurring in other clinical settings associated with seizures. Monitor patients with a history of seizure disorders for worsened seizure control during ZOHYDRO ER therapy.Withdrawal
Avoid the use of mixed agonist/antagonist (e.g., pentazocine, nalbuphine, and butorphanol) or partial agonist (e.g., buprenorphine) analgesics in patients who are receiving a full opioid agonist analgesic, including ZOHYDRO ER. In these patients, mixed agonist/antagonist and partial agonist analgesics may reduce the analgesic effect and/or may precipitate withdrawal symptoms.
When discontinuing ZOHYDRO ER, gradually taper the dosage. Do not abruptly discontinue ZOHYDRO ER.Risks of Driving and Operating Machinery
ZOHYDRO ER may impair the mental and physical abilities needed to perform potentially hazardous activities such as driving a car or operating machinery. Warn patients not to drive or operate dangerous machinery unless they are tolerant to the effects of ZOHYDRO ER and know how they will react to the medication.
Adverse reactions in ≥2% of patients in placebo-controlled trials include constipation, nausea, somnolence, fatigue, headache, dizziness, dry mouth, vomiting, pruritus, abdominal pain, edema peripheral, upper respiratory tract infection, muscle spasms, urinary tract infection, back pain, and tremor.
Serotonergic Drugs: The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome.
Monoamine Oxidase Inhibitors (MAOIs): MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma).
Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics: May reduce the analgesic effect of ZOHYDRO ER and/or precipitate withdrawal symptoms.
Muscle Relaxants: Hydrocodone may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.
Diuretics: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone.
Anticholinergic Drugs: The concomitant use of anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus.
Pregnancy: May cause fetal harm.
Lactation: Not recommended.
You are encouraged to report negative side effects of taking ZOHYDRO ER to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
To report adverse events, a product complaint, or for additional information about ZOHYDRO ER, call Pernix Therapeutics at 1-877-745-3667.
Please see Full Prescribing Information, including BOXED WARNING, before prescribing ZOHYDRO ER.


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The party of your dreams.
Celebrate a birthday with friends or organise the perfect company event – we will create the right experience for every occasion. We can fulfil practically any wish. Four different kitchen teams offer a unique range of culinary styles. You can choose from a number of locations and count on outstanding, professional service.


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SAN DIEGO, Aug. 12, 2013 /PRNewswire/ -- Cardium Therapeutics (NYSE MKT: CXM) today reported on a research collaboration with researchers at Boston Children's Hospital, to assess the medical utility of Excellagen® as a delivery scaffold to seed autologous mesenchymal fetal stem cells for ex-vivo engineering of tissue grafts for transplantation into infants to repair prenatally diagnosed birth defects.
(Logo: http://photos.prnewswire.com/prnh/20051018/CARDIUMLOGO)
Autologous mesenchymal fetal stem cells are derived prenatally from infants with a medical defect requiring life-saving tissue repairs. These stem cells are sourced from amniotic fluid, the placenta or umbilical cord blood. The stem cells are then seeded into a scaffold to promote the growth of an engineered tissue graft. These grafts will potentially be used to surgically repair, either in the fetus or immediately following birth, certain prenatally diagnosed birth defects that could include congenital diaphragmatic hernia, tracheal and chest wall defects, bladder extrophy and various cardiac anomalies. Preliminary pre-clinical research has confirmed that Excellagen collagen homogenate maintains mesenchymal fetal stem cell viability. Additional proof of concept studies are currently underway.
"Boston Children's team has made remarkable progress in the field of tissue regeneration and surgical repair of prenatally diagnosed congenital defects. We believe that Excellagen has an opportunity serve as a delivery platform in the field of stem cell therapy and we look forward to continuing to work with the Boston Children's team to help make their innovative therapeutic vision a new standard of care, and potentially advance stem cell therapies toward commercialization," stated Christopher J. Reinhard, Chairman and Chief Executive Officer of Cardium. "Excellagen was specifically designed to support advanced biologics and this new application further highlights its potential versatility as an important delivery agent for a variety of innovative therapeutic applications."
Cardium's FDA-cleared Excellagen is an aseptically-manufactured, quaternary fibrillar Type I bovine collagen homogenate that is configured into a staggered array of three-dimensional, triple helical, telopeptide-deleted, tropocollagen molecules. This linear array forms a flowable, biocompatible and bioactive structural matrix that can promote chemotaxis, cellular adhesion, migration and proliferation to stimulate tissue formation. The Excellagen homogenate represents a new product delivery platform that allows for the potential development of a portfolio of advanced tissue regeneration therapeutic opportunities that could include anti-infectives, antibiotics, peptides, proteins, small molecules, DNA, stem cells, differentiated cells and conditioned cell media.
About Excellagen®
Excellagen is a syringe-based, professional-use, pharmaceutically-formulated 2.6% fibrillar Type I bovine collagen homogenate that functions as an acellular biological modulator to activate the wound healing process and significantly accelerate the growth of granulation tissue. Excellagen's FDA clearance provides for very broad labeling including partial and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/graft, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, second-degree burns and skin tears) and draining wounds. Excellagen is intended for professional use following standard debridement procedures in the presence of blood cells and platelets, which are involved with the release of endogenous growth factors. Excellagen's unique fibrillar Type I bovine collagen homogenate formulation is topically applied through easy-to-control, pre-filled, sterile, single-use syringes and is designed for application at only one-week intervals.
There have been important, positive findings reported by physicians using Excellagen as part of Cardium's physician sampling, patient outreach and market "seeding" programs. In several case studies, physicians reported a rapid onset of the growth of granulation tissue in a wide array of wounds, including non-healing diabetic foot ulcers (consistent with the results of Cardium's Matrix clinical study), as well as pressure ulcers, venous ulcers and Mohs surgical wounds. In certain cases, rapid granulation tissue growth and wound closure have been achieved with Excellagen following unsuccessful treatment with other advanced wound care approaches. From a dermatology perspective, a previously unexplored vertical market, remarkable healing responses have been observed following Mohs surgery for patients diagnosed with squamous and basal cell carcinomas, including deep surgical wounds extending to the periosteum (a membrane that lines the outer surface of bones). Additionally, because of the easy-use and platelet activating capacity, physicians have been employing Excellagen in severe non-healing wounds at near-amputation status, in combination with autologous platelet-rich plasma therapy and collagen sheet products. These case studies and positive physician feedback provide additional support of Excellagen's potential utility as an important new tool to help promote the wound healing process. Excellagen case studies are available at http://www.excellagen.com/surgical-wounds.html.
About Cardium
Cardium is an asset-based health sciences and regenerative medicine company focused on the acquisition and strategic development of innovative products and businesses with the potential to address significant unmet medical needs and having definable pathways to commercialization, partnering or other economic monetizations. Cardium's current portfolio includes LifeAgain medical data analytics, Tissue Repair Company, Cardium Biologics, and the Company's To Go Brands® nutraceutical business. The Company's lead commercial product, Excellagen® topical gel for wound care management, has received FDA clearance for marketing and sale in the United States. Cardium's lead clinical development product candidate Generx® is a DNA-based angiogenic biologic intended for the treatment of patients with myocardial ischemia due to coronary artery disease. To Go Brands® develops, markets and sells dietary supplements through established regional and national retailers. In addition, consistent with its capital-efficient business model, Cardium continues to actively evaluate new technologies and business opportunities. For more information, visit www.cardiumthx.com.
Forward-Looking Statements
Except for statements of historical fact, the matters discussed in this press release are forward looking and reflect numerous assumptions and involve a variety of risks and uncertainties, many of which are beyond our control and may cause actual results to differ materially from stated expectations. For example, there can be no assurance that Excellagen can be effectively applied to repairing prenatally diagnosed birth defects using mesenchymal stem cells or that it can be successfully developed for this or any other therapeutic application; that case study observations will be reproducible or generalizable, or that results or trends observed in a clinical study or follow-on case studies will be reproduced in subsequent studies or in actual use; that new clinical studies will be successful or will lead to approvals or clearances from health regulatory authorities, or that approvals in one jurisdiction will help to support studies or approvals elsewhere; that the company can attract suitable commercialization partners for our products or that we or partners can successfully commercialize them; that our product or product candidates will not be unfavorably compared to competitive products that may be regarded as safer, more effective, easier to use or less expensive or blocked by third party proprietary rights or other means; that the products and product candidates referred to in this report or in our other reports will be successfully commercialized and their use reimbursed, or will enhance our market value; that new product opportunities or commercialization efforts will be successfully established; that third parties on whom we depend will perform as anticipated; that we can raise sufficient capital from partnering, monetization or other fundraising transactions to maintain our stock exchange listing or adequately fund ongoing operations; or that we will not be adversely affected by these or other risks and uncertainties that could impact our operations, business or other matters, as described in more detail in our filings with the Securities and Exchange Commission. We undertake no obligation to release publicly the results of any revisions to these forward-looking statements to reflect events or circumstances arising after the date hereof.
Copyright 2013 Cardium Therapeutics, Inc. All rights reserved.
For Terms of Use Privacy Policy, please visit www.cardiumthx.com.
Cardium Therapeutics®, Generx®, Cardionovo®, Tissue Repair™, Excellagen®, Excellarate™, LifeAgain™, Genedexa™, Neo-Apps®, MedPodium®, Neo-Energy®, Neo-Chill™ and Neo-Carb Bloc® are trademarks of Cardium Therapeutics, Inc. or Tissue Repair Company. To Go Brands®, High Octane®, Green Tea Energy Fusion™, Acai Natural Energy Boost™, Greens to Go®, Extreme Berries to Go®, Healthy Belly®, VitaRocks®, Smoothie Complete®, Trim Green Coffee Bean™, and Trim Energy®, are trademarks of To Go Brands, Inc. Other trademarks belong to their respective owners.
|SOURCE Cardium Therapeutics
Copyright©2012 PR Newswire.
All rights reserved


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On behalf of Craven County Partners In Education and Craven County Schools, I would like to personally thank everyone involved in the success of our �Stuff The Bus� campaign.
On behalf of Craven County Partners In Education and Craven County Schools, I would like to personally thank everyone involved in the success of our �Stuff The Bus� campaign.
Through the generosity of our community, we received more than 7,000 school supply items with an estimated value of $6,080. Plus, we received cash donations and sponsorships of $2,000, allowing us to serve more than 350 Craven County School children. We also received $3,600 in-kind sponsorships, which helped us to keep our expenses to a minimum.
Thank you to our sponsors who made this event a tremendous success: A Dog�s Dream, The Harold H. Bate Foundation, Coastal Children�s Clinic, Fuel Warehouse, Williams-Scarborough-Smith-Gray CPA, Dr. Todd Rankin and Century 21 Zaytoun-Raines.
Several businesses also dropped off school supplies as we led up to the event which included Morgan�s Restaurant and Hardison and Hardison CPA. Some were made by anonymous donors, and we thank you.
I would be remiss if I did not thank the Marines who arrived to save the day in Havelock. Not only did they help us �Stuff the Bus,� but they also assisted with the sorting of the items for delivery to the schools. A special thank you to Jennifer Krivohlavy with the Single Marines Program at Cherry Point air station for coordinating the Marine volunteers and their transportation to and from the event.
I would also like to thank all of those behind the scenes who played a critical role in the success of this event: Sun Journal, Havelock News, BOB 93.3, and WITN for the coverage; the New Bern Area Chamber of Commerce Minority Business Council, NCAE, and AlphaGraphics, for their partnership; Walmart for allowing us to park the buses in front of the stores in Havelock and New Bern; Chick-fil-A for the gift coupons; Dianne Lane and Lauren Taylor, our very hard working bus drivers; and all of the volunteers who came out to work the day of the event.
The mission of Stuff the Bus is to serve as many children as possible who have been identified as in-need by their school�s guidance counselor and principal with the needed school supplies they require to succeed in school. These school supplies will give them the tools they need to help keep them on the road to learning.
An investment in Partners In Education is an investment in our workforce, our community, and our future. Good things are happening at PIE.
Darlene J. Brown, executive director of Craven County Partners In Education


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Understand SQL Server Management Studio Windows Management
The tool windows in Microsoft SQL Server Management Studio are a highly functional, flexible, and efficient system that allows you to:
Maximize the user workspace for development and management.
Reduce the number of unused windows displayed at one time.
Easily customize the user environment.
Manipulating windows is central to the Management Studio environment. Users can easily access the tools and windows they use frequently. Users can control how much space they want to allocate to different information, and the environment should maximize the space available for editing queries accordingly. Windows can be moved to different locations on the screen. Many windows can be undocked and dragged out of the Management Studio frame. This is particularly useful when using more than one monitor.
To increase your editing space while maintaining functionality, all windows offer the Auto Hide feature, which displays the window as a tab within a bar along the border of the main Management Studio environment. When the pointer is placed over one of these tabs, the underlying window reveals itself. Auto Hide for a window can be toggled by clicking the Auto Hide button, represented by a pushpin in the upper-right corner of the window. There is also an Auto Hide All option on the Window menu.
Some components can be configured in either tabbed mode where components appear as tabs in the same docking location, or in multiple document interface (MDI) mode where each document has its own window. To configure this feature, on the Tools menu, click Options, click Environment, and then click General.
See Also
Other Resources
Use SQL Server Management Studio