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Grade Level: 6th – 8th grade
Subject Matter: Life Science
National Standards: NS.5-8.1, NS.5-8.3
Flowers, such as lilies, irises, roses, daffodils, or tulips – one flower for each student.
Scalpel – one for each pair of student
Magnifying lens – one for each pair of students
Tweezers – one pair for each pair of students
Blank sheets of white paper and pencils, one of each for each student
Black construction paper, one sheet for each student
Pollination: the transfer of pollen from a flower's male reproductive parts to its female reproductive parts.
Fertilization: the union of male and female reproductive cells.
Sepal: the outermost part of the flower that surrounds and protects the flower bud and extends outward from the base of a flower after it has opened.
Petal: the outer parts of a flower, usually brightly colored to attract pollinators.
Pistil: the female part of the flower, which contains the stigma, style and ovary.
Stigma: the sticky part at the top of a flower's pistil, where pollen enters the style and travels to the ovary.
Style: the slender part of a flower's pistil, extending from the stigma to the ovary.
Ovary: the lower part of a flower's pistil, containing its female reproductive cells.
Ovule: a small structure in the flower's ovary that develops into a seed after fertilization.
Stamen: the male part of the flower, which contains the anther and filament.
Anther: the top part of a flower's stamen that develops and contains pollen.
Filament: the stalk-like portion of a flower's stamen that supports the anther.
Prep: Before you present this lesson, become familiar with the anatomy of a flower by researching and viewing diagrams or images online or at the library. Teachers TalkingScience recommends that you hand out to your students printed copies of a diagram of the parts of a flower's anatomy that are explored in this activity. Or you can draw a sketch, based on your research, on a blackboard.
1. Begin the lesson by having students watch the Science Friday video, "Pollen Origami." Ask students to define and describe various methods of pollination. How does the anatomy of a flower support the process of pollination? Tell students that they will dissect a flower to investigate the function of each part of the flower, and how each part helps the process of pollination.
2. Hand out a blank white sheet of paper and a pencil to each student. Tell students that throughout the dissection, they will tape onto this sheet and then label the parts of the flower. Students also should write down their hypothesis of the function of each part of the flower.
3. Hand out a flower to each student. Have students count the number of sepals and petals on their flower, respectively. How do the petals or sepals feel? Based on location, shape, texture and color, what do the students think is the function of the sepals and petals?
4. Instruct students to carefully remove two or three of the sepals and petals so that they can see the inside of the flower. Have students tape and label the sepals and petals onto their sheet, and write down what they think the function of each one is, and why.
5. Tell students that firstly, they will dissect the male part of the flower. Can they guess which part of the flower is the stamen? Help students to identify and count the stamens. How many stamens are there? Why would a flower have that many stamens?
6. Hand out black construction paper, scalpels and tweezers that students can share. Have students remove one of the stamens carefully, using a scalpel and a pair of tweezers. Have students rub the top part of the stamen on their piece of black construction paper. Ask students to examine the pollen with a magnifying lens and describe what they see, including size, shape and color.
7. Have students describe the other parts of the stamen. Instruct students to remove all the stamens and tape them to the dissection sheet, labeling the anther and the filament. Students also should write down why they think the stamen is the male part of the flower, as well as the function of its individual parts.
8. Tell students that now they will dissect the female part of the flower. Have students identify the pistil and feel the top part of the stigma. Why would the stigma feel sticky?
9. Have the students use the scalpel to carefully remove the pistil and cut it in half lengthwise, so that they can examine the inside with the magnifying lens. Can they find the ovary and the ovules? Have students tape both halves of the pistil onto their dissection sheet with their hypothesis on the function of the pistil.
10. Have students compare and contrast their hypotheses on the function of each part of the flower. How are the male parts of the flower different from the female parts of the flower?
Flowers contain male and female reproductive parts. The pistil is the female part of a flower and is comprised of the stigma, style, and ovary. The sticky texture of the stigma, combined with its location at the top of the pistil, helps to attract and adhere pollen grains that may be floating in the wind or clinging to the legs of an insect. The style is the long, tube- like structure leading to the ovary, which contains the female egg cells called ovules.
• What are some adaptations of flower petals to help attract pollinators?
• What are some disadvantages facing flowers that depend on insects for pollination?
• How do non-flowering plants reproduce?
• Identify the part of the flower that will become the fruit.
Extend this activity by having students dissect different types of flowers, or by having students collect flowers from a nearby field or park. Students can observe and record the shape, size, color, and odor of these flowers. Then they can compare their similarities and differences using a Venn diagram. Can they find different species of a common flower, such as goldenrod, and record the differences?


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Vintage Cameras10:59
I came across this vintage camera shop Canemah.etsy.com whilst reading the Frankie guest curator feature on The Storque yesterday. The...
I came across this vintage camera shop Canemah.etsy.com whilst reading the Frankie guest curator feature on The Storque yesterday. They're all reasonably priced too, better then what you'd find them for on eBay. But it does take the magic away from coming across one of these in a vintage store or opshop.
oh, and how amazing is this camera collection?! (via FOREVER IS TODAY)
What do you like to collect?
52 comments
ohhh i would totally love to get my hands on of these lovelies!! i can just imagine all the cool vintage pics that could be taken from them!ReplyDelete
Oh I will definitely check out that shop. But I agree. Half the fun is finding one amongst a pile of stuff and checking out all its features before you buy.ReplyDelete
Awesome pictures! I wish I kept my cameras from growing up.ReplyDelete
:) Marcie
I collect vintage cameras too!ReplyDelete
I'll definitely check out this store! I have about 10 cameras now and I love them all. What I love most is that vintage film cameras always works! And they take amazing pictures too:)
I do love that collection. I have at least 2 of the same cameras. =DReplyDelete
-Andi x
Love this post! I collect mostly lomos but I'm branching into vintage cameras too. I quite prefer finding them IRL mainly because you can better tell their working condition. That said, the shop you've linked to looks pretty amazing :)ReplyDelete
I wish I had a camera collection of great size like these. I have old film compact cameras.. no slr. Would be great if I did.ReplyDelete
Eeek! Ok, I guess I'll be staring on those for a couple more minutes..:DReplyDelete
WOW. I love taking photos and I'd love to have that collection, too! <3 P.S. I used to collect stickers when I was young. Hahaha!ReplyDelete
@Noelle ~ hehe I used to collect stamps!ReplyDelete
I have a collection of Zenits, it is very cheap in Russia))ReplyDelete
less then 50 dollars)
and check out my new project - Story of my Clothes
nice collection. i am collecting boss effects pedal. =)ReplyDelete
@melon ~ haha, Im guessing you're a guitarist!!ReplyDelete
so, so rad.ReplyDelete
Wow. that's an amazing collection.ReplyDelete
I kind of collect cameras too.
but I only have a holga, polaroid, analog SLR, digital SLR and a cybershot of 3years old.
- AnonymousFriday, May 14, 2010
Collecting cameras must be really costly! Maybe I'd turn to collecting shells just because its free.. Haha.ReplyDelete
Best Cheap Digital Camera with No Strings AttachedReplyDelete
If you are looking for a great deal and want to possess the best cheap digital camera available in the market you will be wasting your time googling the term 'best cheap digital camera'. The best way to get your hands on the best cheap digital camera deal is to go to the site mentioned below and take your time picking and choosing. You are sure to find the best deal here.
Visit Smart Shoppers to get yourself the best cheap digital camera available any where.
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corks. happy little corks with dates on them. :)ReplyDelete
I collect retro toys...nothing in particular just as long as I fall in love with them and are different...I got a £2 little black cab from Columbia market in London last weekend and it made me the happiest girl on the planet :-)ReplyDelete
omg, thank you so much for the link to that shop. I've been looking for something like that for a long time. The prices are great!ReplyDelete
xxx kissmequick
ohhhh, this post is making my heart pump fast:)ReplyDelete
you know i'm totally in love with polaroid..i collect and use different types of vintage polaroid cameras..vintage cameras are so close to my heart♥
thanks for the link!
btw, i used to collect stamps too! ;)
Oh! Lovely cameras!ReplyDelete
i'd love to collect cameras. if only i have the budget... at the moment i'm just collecting pretty links and keeping them in my blog :) oh and also people's weekend photos for my other blog heheheh :DReplyDelete
best etsy find ever! i have several very old vintage cameras that i've collected over the years...i just wish i could still get the appropriate film for some! there's nothing like a vintage photograph...ReplyDelete
oh my, these are lovely! im collecting books, it's my favorite thing in this world i thinkReplyDelete
I love taking photographs, capturing moments, good and bad, and it all depends on the camera to what the quality will be like.ReplyDelete
Fab post!
Eda ♥
Please follow: candyflosscurlscupcakesandcouture.blogspot.com
Oh my heart did a little pitter patter.ReplyDelete
As a photographer I must have these. Love all those cameras , thanks for sharingReplyDelete
I want a polaroid camera so badly --- hehehe :)ReplyDelete
my dad collects vintage cameras aswell. he has an amazing collection, but the ones he trauseres more are the ones that used to belong to his father and grandfather, and amazingly, they still work! (its hard to find film for them though =/)ReplyDelete
vintage cameras are the best :}ReplyDelete
my friend's dad collects them .
I would love to own a vintage camera! I may save up and get one :)ReplyDelete
Coooool. I want all of them.ReplyDelete
Last weekend I found in my grandfather's house a very antique camera. "Gevaert" made in my country, Argentina, was very well known during 1940 :)
Now i want a professional camera !
- AnonymousSaturday, May 15, 2010
I'm into photography so I'm a proud owner of a Minolta SRT 202 and Canon XSI. This is a great collection!ReplyDelete
ohhh my gosh, i'm drooling!! haha. i really want one. or all of them (:ReplyDelete
I've collected a few cameras over the years. I've actually had to throw some out because they were either duplicates, or just didn't look as pretty when I had to display them. It was like throwing out an ugly kid :(ReplyDelete
I haven't taken a photo of my collection in a while but here they are
- AnonymousSaturday, May 15, 2010
Awww these are lovely, but unfortunately I don't collect anything at the moment :/ Bit disappointing I know. xxxReplyDelete
@Natasha ~ oh thats ok!! sometimes I wish I didnt collect things, it can become an obsession!!ReplyDelete
wow, i love all those camera's!ReplyDelete
i have only three old polaroid camera's...
i collect so many things: books, beautiful (special) magazines, vintage teacups
and love. ;)
oeeeh i love that, so vintage :)ReplyDelete
I collect cameras, though maybe not consciously :P When I see a camera at a thrift store or a flea market, it's hard not to ask the price. And usually they'll say, "oh, how does 2 bucks sound?" and I'll be like, "hu, fair enough" :PReplyDelete
These are so great, my dad has quite a few vintage cameras and I love hearing about each of their stories and imagining all the places they've been and photos they've taken.ReplyDelete
Thanks for the great find!
p.s. I collect old copies of books I love, like Little Women and Pride and Prejudice...
Oh god I wish I had such a big camera collection.Vintage camera give you some of the most interesting resultsReplyDelete
I want to start collecting more jewellery and books. What do you collect Liss?ReplyDelete
Old (but working) cameras ... I now have over 6/7 cameras, that's not much but at the beginning I didn't want to collect cameras ... I just fall in love with the pictures people take with them and end up by buying them, or find some at my grandma's (one still have some film inside that my mum loaded when she was no more than 20), or they are gifts ...ReplyDelete
i love shooting with vintage cameras//film. totally checking out this site, thanks for the headsUP!ReplyDelete
jess s//
@Sundari ~ I collect vintage fabric, plates, tea cups. and unintentionally collect owl things, cameras, magazines...books..ReplyDelete
I have a few of these. Having vintage cameras to hold/ decorate is almost as special as using them to take photos.ReplyDelete
- Mike ReilleyThursday, June 10, 2010
I have been collecting Polaroid cameras for over 60 years. I have 120 Polaroid cameras of many different models, including the first models made. I displayed these cameras many times at the Bloomsburg Pa Fair and other places. I won money prizes and ribbons.ReplyDelete
I am now 74 years old and it is too much work for me to display them any more so I am selling them. I would rather sell the whole collection at once if I could find someone that was interested.
If you would be interested in any or all let me know and I will give you details. They would be priced anywhere from $10 to $100+. If anyone wants to buy the whole collection I will sell the whole collection for only $7 for each camera. ( $ 840 )
Buy the whole collection and I will add all the accessories that I have free. (Cases,flashes,instruction books etc.)
Ohhhhh...an awesome vintage collection. I would love to have one for sure.ReplyDelete
For all the cool and passionate photographers round the world, engage yourself to buy camera online. High quality camera models including Sony, Kodak, Panasonic, Canon and more for affordable budget and free shipping service. Visit website Zoomin.com.
I dream of owning one of these<3ReplyDelete

subset: commoncrawl


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SAMJ: South African Medical Journal
versão On-line ISSN 2078-5135
versão impressa ISSN 0256-9574
SAMJ, S. Afr. med. j. vol.103 no.4 Cape Town Abr. 2013
Economic appraisal of dabigatran as first-line therapy for stroke prevention in atrial fibrillation
M BerghI; C A MaraisII; H Miller-JansönIII; F SalieIV; M P StanderV
IBCom (Econ & Int Trade), BCom Hons (Econ). HEXOR (Pty) Ltd, Midrand, Gauteng Province, South Africa
IIMSc Math Stats. HEXOR (Pty) Ltd, Midrand, Gauteng Province, South Africa
IIIBChD, DipOdont, PGDipIHE. HEXOR (Pty) Ltd, Midrand, Gauteng Province, South Africa
IVMB ChB, MBA. HEXOR (Pty) Ltd, Midrand, Gauteng Province, South Africa
VBPharm, MPharm. Boehringer Ingelheim South Africa, Randburg, Gauteng Province, South Africa
BACKGROUND: Dabigatran is an oral anticoagulant direct thrombin inhibitor recently registered in South Africa (SA) to reduce the risk of stroke and systemic embolism in patients with atrial fibrillation (AF). Owing to the price disparity between warfarin (the current gold standard for treatment of patients with AF) and dabigatran, we conducted an economic appraisal of the use of dabigatran compared with warfarin from a payer perspective in the South African private healthcare setting.
OBJECTIVES: To estimate the cost-effectiveness (CE) and budget impact of dabigatran compared with warfarin for the prevention of stroke in AF patients.
METHODS: A previously published Markov model was populated with SA cost and mortality data to estimate the CE and budget impact analysis of dabigatran over a lifetime horizon. The model population consisted of a cohort of patients of whom those aged younger than 80 years used dabigatran 150 mg twice daily and those older than 80 years 110 mg twice daily. Modelled outcomes included total cost, quality-adjusted life years (QALYs) and incremental CE ratio (ICER), with the effectiveness measured by QALYs gained.
RESULTS: Dabigatran compared with warfarin as first-line treatment was estimated to have an ICER of R93 290 and an average incremental cost per beneficiary per month of R0.39 over a 5-year period. Conservative assumptions were made regarding the number of international normalised ratio monitoring tests for patients on warfarin, and the ICER is estimated to decrease by as much as 15.7% under less stringent assumptions. A robust sensitivity analysis was also performed.
CONCLUSION: Dabigatran as first-line treatment compared with warfarin for the use of stroke prevention in patients with AF is deemed cost-effective when used in accordance with its registered indication in the SA private sector.
In South Africa (SA), the risk of cerebrovascular disease is significant; it is estimated that approximately 240 strokes occur daily.[1] Worldwide, up to 3 million people per year suffer atrial fibrillation (AF)-related strokes.[2] SA patients with irreversible AF currently use warfarin as first-line treatment. Dabigatran (Pradaxa; Boehringer Ingelheim) is an oral anticoagulant with direct thrombin inhibitory action and was registered in SA in September 2012 for the prevention of cardioembolic stroke in patients with non-valvular AF.
The Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY)[3] trial was a non-inferiority trial with 2-year follow-up, comparing the use of dabigatran with warfarin in patients with AF who were at risk of stroke. A total of 18 113 people in 44 countries were enrolled and randomised into three treatment arms, two blinded dabigatran arms, using two fixed doses of dabigatran (110 mg twice daily and 150 mg twice daily), and a blinded, adjusted-dose warfarin arm. The primary study outcome was prevention of stroke or systemic embolism. The primary safety outcome was major haemorrhage. Secondary outcomes were stroke, systemic embolism and death rates.
Both dabigatran doses were non-inferior to warfarin in respect of the primary efficacy outcome. In addition, the 150 mg dose of dabigatran was superior to warfarin with respect to prevention of stroke or systemic embolism, and the 110 mg dose was superior to warfarin in respect of major bleeding. The RE-LY trial showed relative reductions of 9.5% and 34.3% in the risk of stroke or systemic embolism for twice-daily dabigatran 110 mg and 150 mg, respectively, compared with warfarin. All-cause mortality was reduced by 9.2% and 12% for the 110 mg and 150 mg doses of dabigatran, respectively, compared with warfarin.[3]
Internationally, economic appraisals were performed to evaluate the use of dabigatran for patients with AF. In an economic study in the USA, the estimated cost per quality-adjusted life year (QALY) gained proved cost-effective below a willingness-to-pay threshold of US$50 000 per QALY when comparing dabigatran 150 mg twice daily with warfarin. The cost-effectiveness (CE) was, however, dependent on the pricing of dabigatran in the USA.[4] Economic appraisals performed in the UK had similar results.[5]
In SA, the daily cost of dabigatran is significantly more than the cost of warfarin. Policy makers therefore need to understand the potential economic benefits that might be derived from the use of dabigatran compared with warfarin. Economic appraisals not only provide insight into the economic viability of substituting dabigatran for warfarin, but also assist in policy decision making. The objective of this study was to estimate the CE and budgetary impact of using dabigatran for stroke prevention in patients with AF in the SA private healthcare sector, thereby assisting in guiding policy.
Kansal et al.[5] designed a CE model based on the outcome of the RE-LY trial in 2010. The CE model simulates disease progression and estimates quality of life and incremental cost per QALY for patients with AF in SA.
The CE results were estimated using the sequential dose model setup, which ensures that patients aged <80 years receive 150 mg dabigatran twice daily and patients >80 years 110 mg twice daily. Warfarin-related outcomes from the RE-LY trial are referred to as trial-like warfarin in the CE model, and in the model base case we used this parameter for warfarin utilisation in patients with AF. The 'real-world' utilisation of warfarin in patients with AF, incorporating less stringent international normalised ratio (INR) testing and sensitivity, was investigated by comparing dabigatran with real-world warfarin as first-line treatment.
The CE model developed by Kansal et al.[5] was made available for adaptation to the SA private healthcare setting and populated with SA mortality and cost data. These are discussed under 'Inputs and assumptions' below.
A budget impact analysis (BIA) module was developed by the authors. The BIA module considers and compares a status quo scenario where only warfarin is used for stroke prevention in AF patients, and a new intervention scenario in which some of the AF patients receive dabigatran for stroke prevention. The BIA module is a dynamic model that incorporates the prevalence, incidence and mortality of AF patients in SA. The budget impact is estimated over 5 years and is expressed as the incremental cost per beneficiary per month (ICPBPM).
The CE model and BIA model results were estimated using the basecase scenario parameters as set out in Table 1. Table 1 also indicates the rationale for using these parameters as a base-case scenario.
Event costs used to populate the model were estimated using 2007 medical scheme claims data. The data included 2.1 million claim lines occurring between January 2000 and May 2007. The claims represent all patients who had a claim with a diagnosis code contained in chapter IX of the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD 10) coding system. These claims were adjusted to 2011 values using medical inflation figures as published by Statistics South Africa.[6]
Event costs are defined as: (i) the costs of clinical events that are associated with a patient with AF, notably stroke, systemic embolism (SE) and transient ischaemic attack (TIA); and (ii) the costs of adverse events in patients on treatment for AF related to bleeding tendencies.
Event costs were estimated separately for patients who were physically independent (i.e. able to function independently of assistance from a caretaker or family member) after any event, patients who were only moderately physically dependent, and patients who were totally physically dependent. The model accounts for follow-up costs after a thromboembolic event based on patients' physical dependencies.
Inputs and assumptions
Mortality data
There are no publicly available life tables for the SA medically insured population. The SA85-90 life tables published by the Actuarial Society of South Africa[7] were used as an approximation for the mortality experience of the SA private sector. The mortality rate of the SA85-90 population is greater than the mortality rates used by Kansal et al.,[5] with the difference more pronounced in females than in males.
Drug costs
The cost of dabigatran was supplied by Boehringer Ingelheim SA (BI SA). It is assumed that patients with an INR of <2 will require 5 mg of warfarin per day, those with an INR within the range of 2 - 3, 3 mg of warfarin per day, and those with an INR of >3, 1 mg of warfarin per day. The costs of these drugs are set out in Table 2.
Event costs
The cost of ischaemic stroke (IS) was estimated by calculating the total claimed amount for any hospitalisation during which a patient had a claim reflecting stroke, not specified as haemorrhage or infarction. It was assumed that the median cost of the first quarter of the data is the average cost for a patient who is independent following an IS. Similarly, it was assumed that the cost for a patient who is moderately disabled following an IS is represented by the median cost of the second quarter of the sorted data, the cost of a fatal IS by the median of the third quarter of the data, and the cost for a patient who is totally dependent after an IS by the median of the last quarter of the data. Owing to a lack of robust data, it was assumed that intracranial haemorrhage (ICH), haemorrhagic stroke (HS) and IS all incurred the same cost. SE was estimated by calculating the total claimed cost in hospital, where at least one claim with pulmonary embolism occurred. The cost of fatal cases was estimated using the first quartile of the systemic event costs, and the non-fatal cases were estimated using the third quartile of the costs. A TIA was estimated as the median total hospital cost where at least one claim with TIA occurred. The cost of acute myocardial infarction (MI) was estimated as the median total cost in hospital where at least one claim with acute MI occurred, and it was assumed that fatal and non-fatal MIs have the same cost. Fatal extracranial haemorrhage (ECH) and non-fatal gastrointestinal (GI) bleeds were estimated from the total cost of hospital stay claims. It was assumed that discontinuation of treatment after an event, treatment switch and death from unrelated causes are not associated with additional costs. The event costs are summarised in Table 2.
A patient's follow-up costs subsequent to a stroke were estimated from costs incurred after the patient had been discharged from hospital. A zero cost was assumed when a patient was independent without a stroke history. It was assumed that treatment discontinuation without an event would result in the cost of one consultation. These costs are also summarised in Table 2.
Treatment uptake
The BIA module compares a cohort of AF patients using warfarin with the same cohort should they initiate treatment with dabigatran. The BIA module is based on the assumption that 3 333 AF patients will receive dabigatran for stroke prevention in year 1 (which comprised 20% of the total number of AF patients). Furthermore, it was assumed that the total number of patients receiving dabigatran will increase by 10% per annum. These assumptions are based on market growth projections provided by BI SA.
Warfarin monitoring costs
The INR monitoring cost of patients treated with warfarin is incorporated into the model. The costs for one INR test and one specialist consultation are shown in Table 2. Owing to lack of SA data, the INR testing frequency was estimated using medical schemes' claims data and verified by consultation with two key opinion leaders (KOLs). The claims data are shown in Fig. 1 and suggest a bimodal distribution, indicating that a large proportion of patients receive an INR test twice a month or more frequently, and another large proportion monthly. These two centroids are assumed to represent the average number of tests for uncontrolled and controlled patients. The KOLs agreed that controlled patients will have monthly INR tests, while the frequency of INR tests for uncontrolled patients can vary between daily and bimonthly.
Accordingly, for the base case, it was estimated that patients with an INR within the range of 2 - 3 would have an average of 12 INR tests per annum, while patients with an INR outside this range would have 24. These are thought to be conservative estimates, as many patients receive more than two INR tests per month (Fig. 1). It was assumed that patients with an INR within and outside the range of 2 - 3 will have three and six specialist consultations per year, respectively.
Table 3 sets out the CE results for the base-case scenario with effectiveness measured by QALYs gained. Table 4 shows the BIA results.
Sensitivity analysis
The base-case scenario compared using dabigatran as first-line treatment with trial-like warfarin, with no treatment as second-line treatment.
The choice of comparator when dabigatran was used as a first-line option was altered between trial-like warfarin and real-world warfarin. The ICER decreases to R90 077 (-3.45%) and the ICPBPM decreases by 3.26% on average over a period of 5 years.
Sensitivity analysis was performed on INR monitoring. For the scenario in which a patient's INR falls outside the range, one of the KOLs advised that 'If on long-term warfarin, as many as 36 tests per year might be performed.' Sensitivity analysis on the number of INR tests for uncontrolled patients was therefore conducted and the ICER was estimated with 24 and 36 INR tests annually. The number of INR tests conducted, and the estimated ICER for uncontrolled patients per year, are shown in Fig. 2. The number of tests for a controlled patient was not altered from the base case. The ICER decreases by as much as 15.7% when increasing the number of INR tests for uncontrolled warfarin patients from 24 tests per annum to 36 tests per annum.
The BIA results for an uncontrolled warfarin patient, assuming that these patients receive 30 and 36 INR tests per year, indicate that the ICPBPM ranges between R0.14 and R0.60 for 30 INR tests and between R0.13 and R0.56 for 36 tests. The relative reductions from the base case are 4.7% and 9.4% in the first year for 30 and 36 INR tests, respectively. The average decreases of the ICPBPM over 5 years are 5.2% and 10.5%, respectively.
In the opinion of the KOLs, a stable individual can use up to 20 mg of warfarin a day; sensitivity analysis was therefore also performed on the amount of warfarin used by a patient within the INR range 2 - 3 and that for a patient whose INR is <2. The amount was adjusted to
20 mg a day from 3 mg for a patient within range and from 5 mg for a patient with an INR <2. For a patient with an INR >3, warfarin use remained at 1 mg a day. The ICER decreases to R27 055, representing a 71% reduction from the base-case results. The estimated BIA results reveal an average decrease of 48% over a period of 5 years, ranging from R0.08 in year 1 to R0.32 in year 5.
In this study, we first estimated the CE of dabigatran as first-line treatment compared with warfarin, followed by no second-line treatment. Secondly, the budgetary impact of introducing dabigatran into the SA private healthcare market over a 5-year period was investigated. CE was demonstrated for patients using 150 mg of dabigatran twice daily if aged <80 years, after which they will switch to 110 mg dabigatran twice daily. The analysis estimated the total cost for dabigatran and warfarin, as well as the life years and QALYs for both treatment arms, to calculate the ICER with effectiveness measured by QALYs gained.
At an ICER of R93 290, dabigatran proves cost-effective when compared with trial-like warfarin as a first-line treatment in patients with AF and at risk of suffering IS. The budgetary impact was estimated as R0.15 per beneficiary per month in the first year, increasing to R0.63 in the 5th year. Although this appears to be small, it should be considered by policy makers and healthcare funders as part of their total budget, the burden of disease of their respective risk pools and the potential opportunity cost of funding dabigatran in the future.
The authors considered various clinical scenarios (through sensitivity analyses) to estimate the CE and budgetary impact of treating AF patients with dabigatran as first-line therapy for stroke prevention.
It was observed that the results are not very sensitive to the comparator in first-line treatment when using trial-like or real-world warfarin. The base-case results are considered to be conservative, since the cost offset by avoidance of INR testing through the use of dabigatran reduces the ICER by up to 15.7% under less conservative assumptions. The base-case scenario is also sensitive to an increase in the amount of warfarin used by a patient according to the INR range.
Comparing the model inputs used by Kansal et al.,[5] and the inputs used to populate the model for the SA private sector, the largest relative cost difference was shown for a patient being independent, moderately disabled and totally dependent as a result of IS, IH and HS. The mortality rates used by Kansal et al. were lower than the mortality rates used for the SA health sector. Mortality rates in SA are on average 23% and 27% higher for males and females, respectively, than those in the UK model. This together with the cost differences influenced the results generated for the SA population.
The National Institute for Health and Clinical Excellence (NICE) technology appraisal guidance[8] showed that the INR monitoring costs for the population on warfarin are difficult to quantify accurately. This is due to the variation in the costs of INR testing in the UK, as well as uncertainty about the frequency of INR testing, which is dependent on the patient's INR range. NICE made a key recommendation that dabigatran be recommended as a treatment option for the prevention of strokes in patients with AF, within the licensed indications of use. Furthermore, NICE agreed that a dose of 150 mg was clinically more effective in the RE-LY trial.
We conclude that dabigatran should be considered as a cost-effective option within its registered indication when compared with warfarin. Accurate data on the resource utilisation (specifically frequency of INR testing) associated with stroke prevention in AF will enhance the robustness of the results. Dabigatran is worthy of consideration as a treatment option when managing patients with AF, as it is the only treatment that, when compared with warfarin, provides a superior reduction in IS and HS, which is the main goal of anticoagulation treatment.
Acknowledgements. The authors thank Drs Piet Wessels and Ester van Vuuren for their valuable contribution. Furthermore, we would like to thank Mr Fuad Salie (Head of Market Access at Boehringer Ingelheim South Africa) and Martin van den Berg (BI SA) for their contribution to the research and their review of the manuscript.
Conflict of interest. The study was funded by BI SA. The manuscript was reviewed by key personnel from BI SA prior to submission.
1. Steyn K. Heart and Stroke Foundation of South Africa. Media Data Document. Cape Town: Department of Medicine, University of Cape Town, and Chronic Diseases of Lifestyle Unit, July 2007. [ Links ]
2. World Health Organization in collaboration with the World Heart Federation and the World Stroke Organization. Global Atlas on Cardiovascular Disease Prevention and Control. 2011. http://www.world-heart-federation.org/fileadmin/user_upload/documents/Publications/Global_CVD_Atlas.pdf (accessed 15 December 2012). [ Links ]
3. Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009361(12):1139-1151. [http://di.doi.org/10.1056%2FNEJMoa0905561; [ Links ]
4. Freeman JV, Zhu RP, Owens DK et al. Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrilation. Ann Intern Med 2011;154(1):1-11. [http://dx.doi.org/10.1059/0003-4819-154-1-201101040-00289] [ Links ]
5. Kansal AR, Sorensen SV, Gani R, et al. Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation. Heart 2012;98(7):573-578. [http://dx.doi.org/10.1136%2FheartJnl-2011-300646] [ Links ]
6. Statistics South Africa. Consumer price index, Statistical release P0141. http://www.statssa.gov.za/publications/statsdownload.asp?PPN=p0141&SCH=5455 (accessed 20 March 2012). [ Links ]
7. SA85-90 life tables. http://www.actuarialsociety.org.za/Practice-Areas/Other-Technical-Committees/Continuous-Statistical-Investigations-577.aspx (accessed 1 March 2012). [ Links ]
8. NICE technology appraisal guidance 249. Dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation. March 2012. http://Guidance.nice.org.uk/ta249 (accessed 10 August 2012). [ Links ]
Accepted 15 February 2013.
Corresponding author: M Bergh (email@example.com)


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MLB.com Serving Fake Antivirus Via Malicious Online Ads
Baseball fans browsing MLB.com should watch out, as researchers have identified malicious ads tricking users into downloading fake antivirus software.
One of the ad networks being used by Major League Baseball on MLB.com is displaying malicious ads to site visitors, Perimeter E-Security researchers reported on Monday. When several Perimeter clients who had recently accessed MLB.com began reporting fake antivirus infections, researchers immediately suspected a polluted ad network was at fault, according to Evan Keiser, a security analyst at Perimeter E-Security.
The malicious advertisement was still active, as of 3PM today, Keiser told Security Watch.
"After page-refreshing MLB.com 20–30 times we were finally given the [malicious] redirect," Keiser wrote on the company's blog post.
The malicious ad in question was a luxury watch ad for www.plentywatch.com, Keiser said. The ad was being pushed by an ad server at adginserver.com. Perimeter also saw that the same image was being spread by an ad network on gipcampaign.com, but there is very little information available about either of these groups other than the fact that they were registered fairly recently around the same time by the same person or entity, according to Keiser.
Fake AV on MLB.com
Going from the advertisement to the fake antivirus infection requires "quite a bit" of user interaction, according to Keiser. The user is prompted to download the installation file for the rogue software after clicking on the online ad. The variant, "Windows Secure Web Patch," then pretends to scan the computer and finds problems that it will remove only if the user registers the software for $99.99.
"Needless to say, this program is fraudulent, so do not purchase it," Keiser warned.
Perimeter is currently investigating what other sites are displaying this malicious ad. Keiser said this specific ad server had been serving up fake antivirus on MLB.com as far back as May 25.
"One of the users who reported it to them [mlb.com] didn't seem to have the best experience dealing with their support," Keiser said.
Lucrative Scams
Fake antivirus and other types of scareware are actually a lucrative source of income for cyber-criminals involved in the scam, including the distributors as well as the owners. Distributors get paid for every person that downloads and installs the software and the campaign operators pocket the registration fee from the users. They can also sell of any other personal or financial information the user entered in the registration form, such as addresses and credit card numbers.
Perimeter identified 22 URLs involved with this particular malware campaign, all of them with India's .in domain suffix. It appears some of these domains are part of a large 600-plus pool of domains currently being used in "quite prevalent 'fake antivirus' malware campaign," Daniel Wesemann wrote on the SANS Institute's Internet Storm Center blog. The criminals behind the campaign are frequently changing the executables being pushed to avoid detection by security vendors, according to Wesemann.
How Criminals Use Online Ads
Malicious advertisements are sneaky because they are often served up by otherwise legitimate ad networks. Most website publishers don't display their own ads, but partner with an ad network which has a pool of online ads ready to be served. If criminals have accounts on these networks, they scan slip malicious advertisements into the rotation. Site visitors who click on the advertisement are directed to the malicious site and infected. This way, criminals can infect visitors to a certain website without even going through the time-consuming process of hacking that site.
Early last year, the public website for the London Stock Exchange was hit by a similar campaign when one of the online ads turned out to be malicious.
Online advertisements are a significant problem, so much that several Internet companies recently banded together to fight malicious online ads. Facebook, Twitter, Google, AOL, and the Interactive Advertising Bureau are among the big names behind the new Ads Integrity Alliance. The group's goal is to combat "badware" collaboratively, according to Maxim Weinstein, the organization's executive director.


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Lourdes Care Plus program is open to anyone who carries Medicare Parts A and B. Its benefits include:
- Cafeteria meal discounts: 30% discount in our "All Spice Cafe" for cardholder when presented to cashier.
- Supper Club: available from 4:00 PM - 5:30 PM daily. Includes soup, entree, vegetable, bread & butter, beverage, and dessert.
- Free physician referral services: If you do not have a family physician or need specialty care, we can put you in touch with doctors who can help. Call 1-877-9LOURDES for assistance.
There is no membership or maintenance fee for Lourdes Care Plus. To become a member, call 607-798-5899 and ask for an application to be mailed to you.


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text: Hi! This is Dana. I'm 16 and I started tennis maybe around 5-6 years ago. But I just recently(3 years ago) started to get competitive, and have been with a school team and I started to compete against other schools. I have a lot of power but I don't know how to use it properly. Nice to meet you!


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Interrow spacing requirements at 35 degrees north latitude.
If not spaced correctly, tilted rows of PV modules—a common layout for low-slope roofs and ground-mounted arrays—can end up with the tops of one row shading the bottom of the row behind it. In some cases, the entire production of the partially shaded rows can be curtailed.
A common approach is lay out the array to avoid interrow shading between 9 a.m. and 3 p.m. on the winter solstice—the day when the sun is at its lowest angle and has the narrowest range of azimuth angles. The shadows cast on this day are longer than on any other day of the year.
The amount of shading depends on the row spacing. The required spacing can be calculated based on the site's latitude (the higher the latitude, the longer the shadow); the row height above the ground or the roof surface (the taller the rows, the longer the shadow); and the desired solar window (more space will be required to avoid interrow shading with a wider solar window).
For this example, the PV array is assumed to be facing true south and on a flat surface. If the height (H) of the modules' top edge above the roof or ground is known, along with the sun's altitude (y) and azimuth (z) angles at the start (or end) of the desired solar window, then the required distance (D) between the back of one row and the front of the next can be calculated as:
D = [H ÷ tan(y)] × cos(z)
But, let's face it: Many people prefer to avoid trigonometry, so the formula was used to draw a graph which gives the interrow spacing factor to avoid shading from 9 a.m. to 3 p.m. The graph's x-axis is the latitude of the site and the y-axis is the row-space factor. Simply multiply the factor for your latitude by the row height to calculate the space required between the back of the one row and the front of the next.
This graph works for arrays facing true south on a flat surface. If the array isn't facing true south, and/or the mount surface is pitched, then the calculations become more complicated and you'll have to brush up on your trig!


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Wetzel joins Broadhead following a 22-year run at Colle+McVoy, where he was group creative director. Throughout his career, Wetzel has worked on such iconic brands as Caterpillar, Land O' Lakes, Purina, Pfizer, Bayer, 3M, General Mills and Cargill.
The addition of Wetzel with his background strengthens the fast-growing agency's creative resources and its core focus on the business and life of rural America.
"I have always been impressed by the focus and passion of Broadhead for the rural market," Wetzel says. "They understand their strengths and how they can leverage them on behalf of clients."
Wetzel leads an experienced creative team at the agency, packed with veterans such as Pam Mariutto, Dan Roettger, Jon Montgomery and John Walker. But it wasn't just the existing talent that attracted him. "Broadhead has a clear sense of where they want to take the agency," Wetzel says. "You're going to see us continue to grow."
Agency CEO Dean Broadhead says Wetzel was a natural fit for the agency. "Greg understands our market, our clients and our path," says Broadhead. "We look forward to the future with him at the helm."


text: Lancope, Inc. is a leading provider of network visibility and security intelligence to defend enterprises against today's top threats. By collecting and analyzing NetFlow, IPFIX and other types of flow data, Lancope's StealthWatch® System helps organizations quickly detect a wide range of insidious attacks from APTs and DDoS to zero-day malware and insider threats. Through pervasive insight across distributed networks, including mobile, identity and application awareness, Lancope accelerates incident response, improves forensic investigations and dramatically reduces enterprise risk. Lancope's anomaly detection capabilities are continuously enhanced with threat intelligence from the StealthWatch Labs security research team. www.lancope.com


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Deadline for Urban Food Code Update survey extended to August 29
More than 400 Portlanders have given their feedback on the Urban Food Code Update Concept Report via an online survey. Due to the community's interest in the project and the proposed ideas around farmers markets, community gardens, urban food production, backyard bees and animals, and community-supported agriculture drop-off sites, the survey will stay open until 5 p.m. on August 29.
We welcome your thoughts. Read the concept report and then take the survey.
For more information, please visit the website at www.portlandonline.com/bps/foodcode or contact Steve Cohen at email@example.com or 503-823-4225.


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Military Discount
Better Half
10% off your stay. Excluding all holidays, Spring Break, Christmas and Thanksgiving breaks. Active military only. Must fax military ID to get discount and reservation must be made in the name on ID. Call and make reservations to get discount. Once ID is received, we will confirm the reservation request.


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Can somebody (or more than one person) suggest tips/techniques for getting a blues sound....I've been trying to learn blues piano but I need some help from some pro's
the more specific the better
That's a good point.... that's another reason why it's helpful when you can watch guys do stuff. One of the issues I have is that there's different things you can do depending on whether you're playing alone,or playing with a band. I've never gigged on piano alone (except for solo ballads that I've written) ,but I work on tunes alone at home alot. There are things you can do with two hands on the upper registers when you're playing with a band that you can't do when you're playing alone and trying to supply the bottom with you're left hand. Chord voicings are critical too, and different voicings are important to know when you're moving thru different phrases of the music. Some chord voices put your hands in positions that are difficult to transition out of,especially if you're moving to a riff that requires a crossover during the riff. You may have to start the next riff with the wrong fingers if you don't take the preceding chord voicing into consideration.outstretchedarm wrote:i here ya. sometimes, though, somebody can just drop a trick on you thats like, so simpleand taes your playing to another level.
those are good.
outstretchedarm wrote:thanks for the tip
ricochet wrote:Good blues piano lessons online here: http://www.playpianotoday.com/blues/index5.swf
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Forty-one Big 12 student-athletes have earned recognition on the 2013 Academic All-Big 12 Softball Team, the league office announced.
Elizabeth Paul (Baylor), Rosie Hull (Kansas), Jessice Vest (Oklahoma) and Taylor Powell (Texas Tech) were nominated with 4.00 grade point averages.
Baylor paced all teams with 10 total honorees, including nine first team members. The first team is comprised of 32 selections, while nine student-athletes earned second team recognition.
First team members consist of those who have maintained a 3.20 or better GPA while the second team selections hold a 3.00 to 3.19 GPA.
To qualify, student-athletes must maintain a 3.00 GPA or higher (either cumulative or the two previous semesters) and must have participated in 60 percent of their team's scheduled contests. Freshmen and transfers are not eligible in their first year of academic residence. Senior student-athletes who have participated for a minimum of two years and meet all the criteria except percent of participation are also eligible.


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Published May 30, 2018
Ketchup, mustard, sauerkraut, relish or…gasp…chili, everyone has a favorite hot dog. So what's yours?
Whether you call them hoagies, grinders, subs, or heroes, who's got the... see the Top 5 →
Spicy or sweet? Tangy or hot? Fried or not? Who's the best? see the Top 5 →
When your jeans need a hem or your favorite sweater needs patching, who do... see the Top 5 →
They may be little, but they matter a lot! Who dresses your children to... see the Top 5 →
The place where it is ok to stare. Who has the best designer jewelry in... see the Top 5 →
Who keeps your finest clothes looking brand new? see the Top 5 →
The 2018 Sacramento A-List awards are based on more than 85,000 votes from local Sacramento-area experts.


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Arts Education
Preventing Youth Violence
Education and the Economy
Palmetto State
Career Pathways
Odds and Ends
Quote to Note
Upcoming Events
Arts Education
On April 2, the National Center for Education Statistics (NCES), part of the Department's Institute of Education Sciences (IES), issued findings from the first nationwide arts survey in a decade, documenting the state of arts education in U.S. public schools. "I start from a simple presumption that I think most parents and teachers share: all students should have access to arts instruction," Secretary Duncan said at the release. "For a host of reasons, high-quality arts education is critical to providing all students with a world-class education. So, when I look at the big picture of the 2009-10 arts survey, I see a good news-bad news story." On the one hand, there have not been significant declines in the availability of music and visual arts instruction in elementary and secondary schools. On the other hand, the percentage of elementary schools providing dance and drama instruction decreased from 20% in 1999-2000 to 3% and 4%, respectively, in 2009-10, and, at more than 40% of high schools, coursework in the arts was not required for graduation in 2009-10. "And, unfortunately, the 'arts opportunity gap' is the widest for children in high-poverty," the Secretary noted. Indeed, just a third of high-poverty secondary schools have five or more courses in music, compared to 60% of low-poverty secondary schools, and just a fourth of high-poverty secondary schools have five or more courses in visual arts, compared to half of low-poverty secondary schools. (Note: The Secretary's full remarks are available online.)
Meanwhile, according to a new report from the National Endowment for the Arts (NEA), at-risk students who have access to the arts in- or out-of-school also tend to have better academic results, better workforce opportunities, and more civic engagement.
Preventing Youth Violence
Also on April 2, the Department of Justice hosted the National Summit on Preventing Youth Violence, bringing together mayors, police chiefs, school officials, youth, and other local representatives to report on their efforts to prevent youth violence in connection with the Administration's National Forum on Youth Violence Prevention. Participants included Secretary Duncan, Attorney General Eric Holder, Secretary of Health and Human Services Kathleen Sebelius, Secretary of Housing and Urban Development Shaun Donovan, Director of the Office of National Drug Control Policy Gil Kerlikowske, and White House Senior Advisor Valerie Jarrett. In his remarks, Secretary Duncan commended the work of six cities (Boston, Chicago, Detroit, Memphis, and Salinas and San Jose, CA) that have developed comprehensive plans to help reduce youth and gang violence, improve opportunities for youth, and encourage innovation at the local level. (Note: Senior Advisor Jarrett's remarks are available online.)
Meanwhile, Secretary Duncan unveiled a revitalized StopBullying.gov web site, with new tools and information about who is at risk of being bullied, how to tell if a child is bullying someone else, and concrete steps that individuals, families, and communities can take to address bullying where they live, play, and attend school.
Education and the Economy
Secretary Duncan participated in The Atlantic's March 27 Digital Town Hall meeting, titled "Jobs and Economy of the Future: Educating the Next Generation to Compete," where the discussion focused on how best to prepare students for college and careers. The achievement gap, science, technology, engineering, and math (STEM) jobs, and technology in the classroom were among the principal topics of conversation. The Secretary, joining correspondent and co-anchor of the PBS NewsHour Judy Woodruff, pointed to the massive cultural change needed to improve the educational system and better prepare students to compete in today's global economy. He emphasized better training to produce more effective teachers, making connections between education and careers, engaging students in their passions, and challenging schools to innovate. Moreover, he observed that, while technology has transformed our lives, it does not seem to be utilized to its potential in the classroom.
Palmetto State
Soon thereafter (March 30), the Secretary was in South Carolina for a one-day, three-city visit with Congressman James Clyburn focused on innovative education reform and keeping college affordable for America's families. He began the day in North Charleston, where he joined students, teachers, and business leaders for a roundtable discussion on school reform, bullying, and community engagement. Next, he stopped at Scott's Branch High School in Summerton, where he joined former Secretary of Education Richard Riley to speak with students and teachers about the school's "Creating a Corridor of Innovation" program. With the help of a federal Investing in Innovation (i3) grant, Scott's Branch is implementing a New Tech High School model that is infused with the latest technology for education and executes a project-based learning approach that can help increase college- and career-readiness in high-poverty rural districts. Then, at Allen University, an Historically Black College and University (HBCU) in Columbia, he hosted a college affordability town hall with students.
Career Pathways
A recent "Dear Colleague" letter highlights the joint commitment of the Departments of Education, Health and Human Services, and Labor to promote the use of career pathways approaches as a promising strategy to help adults acquire marketable skills and industry-recognized credentials through better alignment of education, training and employment, and human and social services among public agencies and with employers. The Departments encourage states to line up state resources to support integrated service delivery areas across federal and state funding streams and ensure that interested agencies and partnerswhether focused on education, workforce development, or human and social servicesare fully aware of this joint commitment for improved collaboration and coordination across programs and funding sources. While there are a number of definitions of career pathways, this term generally refers to a series of connected education and training strategies and support services that enables individuals to secure industry-relevant certification and obtain employment within an occupational area, as well as to advance to higher levels of future education and employment within that area.
Odds and Ends
The Department has issued notices inviting applications for "validation grants" (up to $15 million) and "scale-up grants" (up to $25 million) through the Investing in Innovation (i3) Fund. School districts, groups of schools, and non-profits organizations in partnership with districts and schools are eligible to compete for these grants, with applications due May 29. Grant awards will be made to those with the strongest proposals for expanding promising or effective educational practices to improve learning. (Note: A pre-application for "development grants" [up to $3 million] was announced last month, due April 9.)
On March 28, the Secretary testified before the House Education and the Workforce Committee on priorities in the President's Fiscal Year 2013 budget.
On March 30, the Secretary announced that nine more states (Arkansas, Colorado, Delaware, Illinois, Indiana, Massachusetts, Nebraska, North Dakota, and Pennsylvania) will receive funds to turn around their persistently lowest-achieving schools through the School Improvement Grants (SIG) program. (Note: A blog post highlights preliminary achievement data from the first year of efforts under SIG.)
A new NCES "First Look" report presents findings from a spring 2011 postsecondary education data collection on student enrollment, graduation rates, and financial statistics.
Materials presented during the NCES Testing Integrity Symposium (February 28) are available online.
Based on comments received from the general public and key stakeholders, the Department made a number of changes to its Strategic Plan for Fiscal Years 2011-14.
Quote to Note
"Despite the brutal budget climate in the states and in Washington, arts education must not just survive but thrive. A well-rounded education is simply too vital to our students' success to let the teaching of the arts and humanities erode. Some states and districts are leading the way in protecting and expanding arts instruction. In Boston, under Mayor Thomas Menino's leadership, the city has formed a fantastic partnership with foundations and philanthropists to work toward the goal of providing arts education for all students as a core component of excellent schools. Three years ago, Boston launched a $10 million public-private initiative to bolster arts education, and it is producing big results. This year, 14,000 more Boston students are getting arts instruction than did in 2009. And, twice as many high school students are accessing arts learning during the school day. Boston is helping lead the nation where we need to go. So, working collectively, let's follow their example."
|Secretary of Education Arne Duncan (4/2/12), in remarks at the release of a nationwide arts survey
Upcoming Events
The Department is hosting a series of webinars over the coming months focused on community colleges. The next webinar will be held April 26, from 12:30 to 2:00 p.m. Eastern Time. The theme is "Promoting College- and Career-Readiness: Bridge Programs for Low-Skilled Adults." (Note: Both audio and video of the initial two webinars are archived online.)
This spring, First Lady Michelle Obama will deliver commencement addresses at Virginia Tech University, North Carolina A&T University, and Oregon State University.
April 11-14, the Department will exhibit at Council for Exceptional Children's (CDC) Annual Convention in Denver. If you are attending this event, please stop by the Department's booth. Also, on April 11, at 3:00 p.m. ET, Secretary Duncan and Assistant Secretary for Special Education and Rehabilitative Services Alexa Posny will join the CDC for a Twitter Town Hall.
Credits, Subscribe & Unsubscribe
Please feel free to contact the Office of Communications and Outreach with any questions:
Deputy Assistant Secretary, Intergovernmental AffairsStacey Jordan, (202) 401-0026, email@example.com
Program AnalystAdam Honeysett, (202) 401-3003, email@example.com
To be added or removed from distribution, or submit comments (we welcome your feedback!), please contact Adam Honeysett. Or, visit http://www2.ed.gov/news/newsletters/edreview/index.html.
This newsletter contains hypertext links to information created and maintained by other public and private organizations. These links are provided for the user's convenience. The U.S. Department of Education does not control or guarantee the accuracy, relevance, timeliness, or completeness of this outside information. Furthermore, the inclusion of links is not intended to reflect their importance, nor is it intended to endorse any views expressed, or products or services offered, on these sites, or the organizations sponsoring the sites.


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Patient Center
October 10, 20199:30 AM
Thank you for choosing us for your medical needs.
If you are unable to find a desired time, please call our office directly at (303) 839-6001 and we would be happy to assist you.
**Be sure to read ALL of the following instructions before you schedule your appointment.**Please note that Denver Health Medicaid and Humana are no longer accepted.If you need to schedule your post-op visit, please be sure to select the physician who performed your child's surgery. This will ensure you receive care from a provider who is familiar with your child's needs, the surgery performed, and any special follow up instructions.If you are needing a gastrostomy button change, G-button site check, or a pectus brace adjustment, please select the Current Patient appointment option.New patients, please arrive 15 minutes before your scheduled appointment time. New Patient Paperwork can be downloaded by clicking here.Thank you, again, and we look forwarding to seeing you!
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All Styles
About Kids' Vegan Shoes
Looking for vegan friendly shoes for the kids? The TOMS Kids' Vegan Featured Shop offers an assortment of kids' shoes made of vegan and recycled materials and using no animal products. Our vegan slip on shoes offer comfort and durability for casual and everyday wear. These boys' and girls' shoes are available in a variety of solid colors and bold prints and also come in both youth and toddler sizes. Each pair of shoes purchased, TOMS gives a pair of shoes to a child in need. One for One®.


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Fox News Omits Crucial Statement In Discussion About A United Nations "Global Tax"
On the September 29 edition of Fox News' Bulls and Bears, host Brenda Buttner and fellow Fox News contributors persisted in fear-mongering about a United Nations proposal for implementation of a "global tax" and failed to report on a statement from the U.S. Mission to the U.N. that threw cold water on the claim.
Buttner argued to a panel of Fox News contributors that the U.N. global tax proposal "could happen, couldn't it?" She was referring to a FoxNews.com report on the United Nations, which summarized the tax proposal as the following:
A 1 percent tax on billionaires around the world. A tax on all currency trading in the U.S. dollar, the euro, the Japanese yen and the British pound sterling. Another "tiny" tax on all financial transactions, including stock and bond trading, and trading in financial derivatives. New taxes on carbon emissions and on airline tickets. A royalty on all undersea mineral resources extracted more than 100 miles offshore of any nation's territory.
Approximately 24 hours after this story was published, a spokesman for the U.S. Mission to the United Nations sent the following "unsolicited statement" to Fox News:
The United States opposes global taxes because we believe that any source of revenue should remain under the control of national authorities. This is an idea that has been kicked around for years. Fortunately, it hasn't gone anywhere, nor will it.
In fact, Fox News reported a similar story over a decade ago, but the host of Bulls and Bears Brenda Buttner, nor her panel -- consisting of Gary B. Smith, Stephane Fitch, Kyle Harrington, Jonas Max Ferris, and Tobin Smith -- presented the facts of the global tax initiative.
Instead of acknowledging the statement or the tax proposal's impotent history, Buttner's panel - consisting of Gary B. Smith, Stephane Fitch, Kyle Harrington, Jonas Max Ferris, and Tobin Smith -- largely buttressed Buttner's fear-mongering about global taxes. Only Fitch questioned the necessity of the segment, arguing that "it's not going to happen," in part because "the U.N. has no taxing authority."


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About the Serapeum in Saqqara...
It's so much easier for Tony to fantasize than it is for him to practice independent thought on this, or any other, subject...
So, here's a link:
https://nathandickey.wordpress.com/2014 ... -of-egypt/
Moderators: Minimalist, MichelleH
"...show intense field change at high latitude, localized in a distinctive circular daisy-chain configuration centred on the north geographic pole. Here we show that this feature can be explained by a localized, non-axisymmetric, westward jet of 420 km width on the tangent cylinder, the cylinder of fluid within the core that is aligned with the rotation axis and tangent to the solid inner core. We find that the jet has increased in magnitude by a factor of three over the period 2000–2016 to about 40 km yr−1, and is now much stronger than typical large-scale flows inferred for the core..."
"...We document discovery of a distinct Pt anomaly spread widely across North America and dating to the Younger Dryas (YD) onset. The apparent synchroneity of this widespread YDB Pt anomaly is consistent with Greenland Ice Sheet Project 2 (GISP2) data that indicated atmospheric input of platinum-rich dust..."
Tiompan » Wed Mar 08, 2017 11:15 am
"The empirical evidence was posted here a while ago , it is obvious that you didn't read or understand the links .
Empirical evidence is not something that you can provide , that's why the breath wasn't being held .
Here it is again " it might be a start to provide evidence for the stones being "strategically spaced " and them being "placed in sulphuric acid ".
If either of these suggestions had any truth it wouldn't be difficult to prove it .
The engravings were done with stone toki . Again , even more elaborate engravings were done millenia before the discovery of metals .
Still no answer to whether you come up with the fantasies or get them from the saddo sites .
Is Circumspice right ? If so , do tell us the source ."
"...A total of 887 moai have so far been catalogued on Easter Island, including 397 at the quarry – the volcanic crater of Rano Raraku. Rano Raraku is one of the world's most extraordinary and evocative archaeological sites. A great many statues were being sculpted there when activity apparently came to an abrupt halt.
Francis Mazière writes:
Here in this lunar landscape they carved giants that belong to another world; the impression is shattering. Everything here is on the most tremendous scale, and it all gives rise to a strong feeling of distress, for everything seems to have stopped suddenly, in a single day, as though it had been hit by the blast of some enormous disaster. ... It is this which gives the sanctuary its unearthly feeling.2..."
"...Most of the 900 moai in the island come from the slopes of the Rano Raraku volcano..."
"...Recently, some new evidence has appeared that the feat of building the Egyptian pyramids was accomplished largely with machine tools..."
Tiompan wrote:Of course evidence was provided for you , you either didn't read it or understand it .
Meanwhile you have failed to provide anything like evidence yourself .
Don't judge others by your standards , a lot more complex engravings were done much earlier than those on the Island .
You still haven't told us the source of your fantasies .
"...the ultimate "smoking gun", this cannot be explained by conventional methods...when they opened this tomb, in December 2012!, the head of archaeology of ancient Egypt said to CNN, to MSNBC, to Aljazeers,... "we don't know how this was done!"...and that's honest, we appreciate his honesty, because Egyptology cannot explain this in any way!..."
http://www.khemitology.com/Brien Foerster- "...We now have substantial evidence to show that advanced machining technology existed in Egypt before the time of the Pharaohs. Watch the evidence in this video. And visit Egypt with us:
"...and so, we believe that the great pyramid and the other two pyramids on the Giza plateau are far older than the dynastic Egyptians by several thousands of years and were destroyed in a giant cataclysm of some kind which was global in nature approximately 12,000 years ago..."
"...there sits all those artifacts..."
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We pride ourselves on our high quality caladium bulbs and selections of varieties offered. All of our caladium bulbs are hand-graded and hand-counted by experienced employees.
Caladiums Online offers the highest quality standard and unique caladiums. We offer only the large Number One and premium Jumbo caladium bulbs, which yield more and bigger leaves per plant. Our selections include exclusive, unusual, patented, and new caladium varieties. Prices are reasonable and have no added shipping and handling charges. With easy care and minimal maintenance you can have maximum color for your home, lawn and garden all summer long.
Please Note: Caladium bulbs are available on a first come-first served basis. Your caladium order will be reserved when we receive it. Some varieties sell out before the season is over.
We accept Mastercard, Visa and Discover.
We offer free shipping via UPS within the Continental United States.
You may request a ship date of April through June 1, weather permitting. We do not ship when temperatures are below 40F.
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(c) 2019 Bates Sons & Daughters - Caladiums Online
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The official Shirebrook Town Football Club app
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This website is part of the Pitchero Football network. Create your own free Football club website with Pitchero.
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Louisiana Department of Wildlife and Fisheries (LDWF) Secretary Robert Barham announced the following closure to recreational and commercial fishing in a portion of St. Bernard Parish effective immediately today, July 2.
This precautionary fishing closure is due to strong east to southeast winds and higher than normal tides influenced by Hurricane Alex and the proximity of oil in portions of inshore and offshore state waters.
The portion of state waters in St. Bernard Parish north of 29 degrees 47 minutes 00 seconds north latitude from the double-rig line in Breton and Chandeleur Sounds westward to 89 degrees 25 minutes 00 seconds west longitude.
Precautionary closures of recreational and commercial fishing have been implemented based on the best information the Secretary of the department receives from field biologists, staff and trajectory models from NOAA.
Once reports of oil are received, LDWF initiates a field survey and immediate seafood testing in the suspected areas. Closures are subsequently made with the intent to be as safe as possible, while not closing any fishing areas unnecessarily. As test results come back clearing the area, effected waters are then reopened.
LDWF continues to work closely with DHH in an effort to assess all opportunities to resume normal fishing activities on Louisiana's coast and guarantee the safety of Louisiana's seafood.
For more information related to the oil spill, visit http://www.emergency.louisiana.gov. Connect with us on www.facebook.com/GOHSEP and on Twitter as @GOHSEP. View photos from the state's response efforts at http://www.flickr.com/photos/lagohsep.
For more information contact Marianne Burke, 225-765-2917 or firstname.lastname@example.com.


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Thanks to this forum, I learned about the direct route from the ranger station to the summit of San Jacinto. I've seen it called the Sid Davis route or the Tamarack route. For those who don't know, it's almost a perfectly straight shot from the ranger station to the summit, which means it's short, but STEEP.
My partner and I did this on Tuesday and it was amazing: perfect weather window (cloudless blue skies, no smog, temps around 30s at 8500' and 20s at the summit at 10800', very little wind, and a clearly marked and packed path. We got a late start (11:15am tram) and were surprised how empty it was: we saw one guy in boots hiking down, and ran into another pair of snowshoers at the summit, and nobody else on the entire mountain.
Good condition snow, perhaps a little crunchy on the way back. There was about 1 foot at the base and probably 4 feet of snow at the summit. Looking at the long valley camera this evening it looks like long valley got another 2-3 feet, which suggests the summit might be getting slammed. I bet all of the nicely packed down tracks are gone.


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When writing my thesis in LyX, I encountered the following problem:
After finishing a chapter, I wrote
\break in order for LyX to start writing the next section in the next page.
The problem is that LyX automatically spaced the last page of the first section, so that the last word will appear in the end of the page. It caused a very big space between the beginning of this page and its ending.
Does someone know how to fix it?


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Baked Roasted Squash, Ricotta and Fusilli
This recipe is from Guiding Stars, Baked Roasted Squash, Ricotta and Fusilli. They contacted me about an important topic of overeating for the holidays. We are all so tempted by divine appetizers and desserts over the holidays but if you eat a healthy meal before you go out you will be less likely to overindulge.
I was drawn to this recipe as you know we love to do vegetarian meals at least once a week. This sounded amazing and it really was. Simple ingredients combined together to give a very satisfying meal. The nutmeg plays a very important role in the recipe, so if possible use freshly grated or at least a newer nutmeg that hasn't lingered in your spice cabinet for decades.
- 1 lb. peeled, seeded butternut squash, cut into ½" pieces, about 3 cups
- 1 large sweet onion, Vidalia, Walla Walla, Maui, large diced
- ¾ tsp. freshly grated nutmeg
- Salt to taste
- Freshly ground black pepper
- 1½ Tbsp. olive oil
- 8 oz. pasta, like fusilli or rotelli
- 2 cups fat free ricotta cheese
- 3 Tbsp. Parmesan cheese
- Preheat oven to 375F. On a large rimmed baking sheet. Toss squash and onion with the olive oil. Season with salt, pepper and the nutmeg. Lay out the vegetables to a single layer. Roast for 35-40 min. Stir for the last 5-10 min. The squash and onions will start to brown lightly. Reduce heat to 350F.
- Meanwhile cook the pasta according to the package instructions and drain.
- Mix together 1 12/ cups ricotta and 2 Tbsp. Parmesan. Toss the warm pasta into the cheese. Season with salt and pepper.
- Add the roasted veggies to the bowl and gently toss to combine. Spray an 8x12" pan with cooking spray and transfer the pasta to this dish. Spread on the top the remaining ricotta and sprinkle on the Parmesan cheese. Cover with aluminum foil and bake for 15-20 min. Broil for 3-4 min. until lightly browned and serve.
Recipe adapted from Guiding Stars


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Plain and Simple Quilt Shop
Plain and Simple Quilt Shop is creating a community of quilters in Apex, North Carolina.
Friendly Farmhouse
Tom and Sharon Reilly have created a welcoming atmosphere at Plain and Simple Quilt Shop in Apex, North Carolina. The quilt shop is housed in a 106-year-old farmhouse and encourages quilters to gather. "Making friends is so important," Sharon says. "I want quilters to feel like my shop is their home away from home."Related Links
Small Classes
Classes are held in one of the four farmhouse rooms. Classroom size is small, which means that the student-teacher ration is always low. Elegant But Easy, a quilt made using precut 2-1/2" strips, is one of the classes offered.Related Links
Meet the Staff
Front row, from left to right: Tom Reilly, Sharon Reilly, Linda McDermott, Kathy Moore, Laura Lapp, and Teri Berrier; second row: Jeannette Sites, Ann Waterman, Jennifer Grover, and Linda Kay Stone; third row: Sara Schmitt, Elizabeth Povse, Kim Mohr, and Corinne Kerns. Not pictured: Barbara Becker.Related Links
The Beauty of Appliqué
Sharon specializes in appliqué, which works well done in her favorite fabrics. "We have no brights, no batiks," Sharon says. "Other shops do that well, so we decided to keep our focus on the old-timey look."Related Links
Not Just Quilting Cotton
Shelves at Plain and Simple Quilt Shop are brimming with textiles and samples, including over-dyed wools from two local artists.Related Links
Inspiration in Every Corner
Baskets, shelves, and cabinets host the fabric bolts, precut fabric, quilt samples, and patterns at Plain and Simple Quilt Shop. Displays throughout the shop create a homey atmosphere and provide creative inspiration.Related Links
Importance in Community
Sharon's mission is to make the shop a big part of the Apex community so people feel they belong. "Owning this shop fulfills my need to give back to the community and to create a place where people can come to talk, to laugh, and sometime to cry," she says.Related Links
Times Remembered
Garden scenes of the past are outlined in the center of each block of Times Remembered. Shop owner Sharon Reilly designed Times Remembered for Quilt Sampler magazine.Related Links
Nostalgic Scenes
Each scene was echo-quilted with gentle curves to mirror the embroidery details.Related Links
Times Remembered Color Option
Instead of embroidery, quilt tester Laura Boehnke showcased fussy-cut nature scenes from Holly Taylor's Lakeside Resort collection for Moda Fabrics in the framed panels of the Times Remembered color option.
Contact Plain and Simple Quilt Shop to purchase a copy of the Spring/Summer 2010 issue of Quilt Sampler. Issues are also available at your local quilt shop, on newsstands, and online.Related Links


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