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June 13, 2008 - (BRONX, NY) - Researchers at Emory University School of Medicine and Albert Einstein College of Medicine of Yeshiva University have helped to discover important new information about the cause of Fragile X Syndrome, the most common form of inherited mental retardation. The study appears in the June 10 issue of Developmental Cell, and was led by Gary J. Bassell, professor of cell biology and of neurology at Emory and Robert H. Singer, Ph.D., professor and co-chair of anatomy and structural biology at Einstein.
Fragile X syndrome is caused by the absence of a protein known as FMRP (fragile x mental retardation protein). FMRP is necessary for brain signaling at the synapse, the site where two neurons communicate via chemical and electrical systems. This signaling is essential for normal brain development, learning and memory.
The researchers found how the lack of FMRP in Fragile X Syndrome interferes with this vitally important signaling process. Their results may lead to the development of new treatments for Fragile X Syndrome, which also contributes significantly to autism spectrum disorders and epilepsy.
FMRP—the protein that causes Fragile X Syndrome when absent—is known to be an mRNA (messenger RNA) binding protein. mRNA's are the molecules that convey the DNA sequences of genes from the cell nucleus out to the cytoplasm where the mRNA message is transcribed into proteins. By regulating mRNA molecules, mRNA binding proteins crucially influence how proteins are synthesized from mRNAs.
The precise functions for FMRP have been unclear, but scientists recently have learned that FMRP can bind to and regulate several mRNAs that are present at synapses in the brain. Each mRNA molecule can be translated many times at the synapse, producing many copies of the encoded protein and providing an efficient way for a neuron to supply its synapse with essential proteins needed for communication.
Until now, it wasn't clear how FMRP and its bound mRNAs are delivered to the tentacle-like projections of neurons—their axons and dendrites--and then on to the synapses at their outer extremities.
"A major question in neuroscience is how mRNAs that code for proteins crucial for neuron-to-neuron communication can be precisely transported over long distances to where they are needed--and then be regulated at exactly the right moment to permit communication between neurons, ultimately leading to learning and memory," said Dr. Singer, who also is professor of neuroscience at Einstein.
"FMRP is a protein that can target messenger RNAs destined for the farthest reaches of the cell and deliver them at the right place and time for synaptic signaling to occur," added Dr. Bassell.
The researchers and their colleagues have developed high resolution microscopic imaging tools to visualize FMRP in live neurons, allowing them to track the movements of FMRP and its associated mRNA molecules along dendrites, using cultured neurons isolated from the hippocampus of mouse embryos. They discovered that FMRP binds to a molecular motor, which allows it to carry its bound mRNAs in the form of particles out into the dendrites.
Using a mouse model of Fragile X Syndrome, the investigators saw that mRNAs were not motored into dendrites in response to synaptic signaling. The result: a lack of the local protein synthesis at synapses that is needed to sustain the signaling between nerve cells. In essence, Fragile X Syndrome occurs because neurons have lost the ability to send protein-coding messages from their nuclei to their synapses.
The researchers also were able to identify the select group of mRNAs that, under normal circumstances, the neuron ships into dendrites via FMRP. Knowing which molecules within the FMRP pathway function at synapses should facilitate the development of new treatment strategies and drug interventions for Fragile X Syndrome.
In addition to senior authors Drs. Bassell and Singer, the lead author on the paper was Jason B. Dictenberg of Hunter College, City University of New York and Albert Einstein College of Medicine. Other researchers were Sharon A. Swanger, Emory University Department of Cell Biology and Laura N. Antar, Albert Einstein College of Medicine.
The National Institutes of Health and the Fragile X Research Foundation funded the research.
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Preparing For The Holidays And Learning To Be Helpful
Here's a wonderfully simple way to focus on helping others as the holidays approach. All you need is a large jar and some sort of item to use as a "counter". In our house, we used dried pinto beans. Pennies would also be a good counter, or even pebbles.
One of my husband's and my main goals as the holidays approach is to teach our children about the gift of giving of ourselves. We do this by focusing on ways to be helpful without being asked and without fanfare or reward. The focus is on the act of kindness. To reinforce this lesson, we set a large jar on the kitchen counter along with a shallow dish with a supply of dried beans in it.
Each time one of us (children and adults alike) was helpful to another family member, a friend, a neighbor or even a stranger, we moved a bean from the dish into the jar. Over the next several weeks, we watch the number of beans in the jar grow. We also talk about being helpful on Sundays when we are all dining together. We share ideas of how to be helpful and come up with new ways to help and try out during the upcoming week.
These small acts can be something simple, such as helping a schoolmate at the water fountain or aiding in a search for a lost toy or item. Or, it can be something larger, such as helping with the dishes when it isn't even your turn, or cleaning up your room without being told. Regardless, everyone is on his or her honor to help "fill the jar".
On Christmas Eve, after the kids go to sleep, "Santa" comes to our house and replaces the beans with something a bit more festive, such as chocolate candies or jellybeans. There are usually "a few more" than there were beans. After all, Santa's a very giving person as well! It helps tie in this wonderful lesson we want our children to learn with the fun of Christmas.
This is a great idea to try year-round. Once the jar is filled, the family can trade it in for something special, such as a trip to the movies or an ice-cream night. If using pennies, trade in the pennies for folding change and use that for the special reward!

subset: commoncrawl


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By Dirk Hayhurst
Manny Machado's head is awfully crowded lately, what with all the people who've crawled inside, trying to figure out what the malfunction is.
And, let's be honest, there has to be some kind of malfunction. How else can you justify throwing a bat 90 feet at another player?
Don't tell me it was an accident, Manny; that the bat slipped and you honestly meant to swing at a pitch that was already in the catcher's mitt. You can't be one of baseball's brightest young stars and play off the incident like you're also one of its dumbest -- that you not only temporarily lost your mind, but your instincts as a player, too?
This is what happens when baseball is left to police itself. When autocratic rulers come to power based not on age, maturity, experience, or wisdom, but based on production, success at a kids games and social clout. This is how you have the kind egregious stupidity you saw Manny Machado display this weekend passed off as an accident. Heck, even if you were to look at it from the premise of baseball's unwritten rules -- a concept that is overwhelmingly stupid in and of itself -- what Machado did was still dumb.
Let's rewind and put things in perspective, dissect how a simple tag play can be evolve into attempted assault with a 34-inch hunk of flying, flame tempered lumber.
Last Friday, June 6, Manny Machado was tagged out by Josh Donaldson while progressing to third base on infield groundball. It was a routine play for Donaldson; a ball hit in front of him, pulling him forward to field the ball on a good bounce, then make the a throw across the infield in concert with the direction his weight was already moving. It was all standard save for the fact that Manny Machado was passing in front of Donaldson while it was happening.
As any good runner would, Machado deviated out of the baseline to avoid getting tagged easily by Donaldson, and hopefully disrupt him from making a play in the process. Since Donaldson is programmed to get the lead runner and Machado was right in front of him, and his weight was already heading forward, he tagged Machado instead of making a cross-field throw.
Nothing out of the ordinary, at least not until Machado lost his balance, toppled over, threw his helmet and screamed in outrage that Donaldson's tag was malicious.
But Donaldson's tag was anything but malicious. If tags are like handshakes among men trying to show virility through grip strength, Donaldson's tag was on the sissified end of the spectrum. Players are taught to put tags on opposing players hard. Not because it's chance to dole out contact in an otherwise no-contact sport, and not because it's a chance hit someone without getting a flag on the play. It's because if a tag is made firmly and obviously, there is no debate about whether the tag was actually applied. A manager need not come out of the dugout to argue angles and replay doesn't get consulted. If a player is physically moved by the force a tag, there is no doubt it was made.
For argument's sake, let's take Machado's side for a second. Let's say that Donaldson's tag was a full on crosscheck. Even then, according to baseball's unwritten codes, Donaldson is in the clear. Why? Because he had the ball, was expected to make a firm tag, had more playing time than Machado, was older and was after a runner who left the running lane. All signs -- written and unwritten -- pointed to Donaldson's actions being legal.
It was only when Machado popped up off the ground and got in Donaldson's face that things got out of hand. Indeed, another of baseball's unwrittens kicked in -- the nuclear ones.
Teams think in a pack mentality. In fact, that's how unwritten rules are born in the first place. It may be more apt to say they suffer from a pack mentality, or at least from a crippling dependency on Group Think. In baseball, rules get invented by older guys. Younger guys find it easier to acquiesce than to challenge those rules. Heads are kept down, lines are fallen into, and preferences get passed off as things that have always been.
Given the chaotic nature of baseball, the competitive nature of those who play it, and ego required to endure its peaks and valleys, most players are insecure. If they are secure, give them two weeks worth of bad results and constant media scrutiny over their worth as a player and a person and that will change.
Confidence, bravado, machismo; it's all projected to help compensate for what isn't always naturally available. It's how lines like, act like you've been there before and fake it until you make it are canonized. When you examine those cannons, you realize there aren't a lot of people who've been there before if they have to act like it all the time, and many don't know what it looks or feels like to make it if they have to constantly fake it.
Imitating behavior, following others, blending it -- these are survival mechanisms in a high profile, high-risk environment like baseball. You don't question where rules come from, you just accept you don't know, focus on what you do, and, when in doubt, follow what everyone else does. Thus, when one of your star players flops on the ground soccer player style and throws his helmet like a petulant five year old, you don't hold a vote to discuss rushing on the field to brawl in his honor, you just do it because that's what everyone else doing.
Machado was clearly in the wrong to start a beef with Donaldson. But once he did, the big, red, launch button was pressed, and his team was militarized. From there, it became a matter of respect -- that infamous word the written rules say is taught by winning and losing, but the unwritten rules say can only be taught through physical violence.
But Machado didn't just bring his team on the field, he brought Donaldson's A's on as well. After all, another rule is that you always back up your teammate. The A's weren't just going to let Donaldson get trampled out there. Machado became baseball's Helen of Troy, the angry face that launched millions of dollars of athletic talent into battle.
Many pundits around the game have defended Machado for throwing his bat, his helmet, and getting into the face of Donaldson saying it's simple immaturity. And they're right, it is. Machado's young and brash, and while he may be too prideful to admit he was wrong now, in a couple years, he'll look back and realize there was no reason for him to get upset, and that it would have been better just to let it all go.
But that's not because baseball will have taught him an exclusive lesson, or that the policing of the sport works. That's because Machado got older. Boys become men in all walks of life, even, dare I say it, ones where fastballs to the head aren't learning tools. Baseball doesn't own the market on personal development. And thank God for that because baseball's maturing process looks a hell of a lot more like a doomsday device that insures everyone's mutual destruction than it does a balanced and functional member of society.
Donaldson was already thrown at and hit by Orioles' pitchers as retaliation for his offense against Machado. In turn, Machado was thrown at by A's pitchers as retaliation to retaliation.
Ironically, many of baseball's "mature" players who live and die on the baseball code (and oodles of fans who subscribe to its tenets) feel the issue would've be done if Machado had stood at the plate and worn the pitch like a man. He didn't. Instead Fernando Abad's pitch missed its mark, and Machado -- retaliating for the retaliation against his team's retaliation -- swung woefully and blatantly late as part of a poorly disguised excuse to launch his bat down the line in the direction of third baseman Alberto Callaspo.
Throwing bats at players… some people call that escalation. Buck Showalter calls it learning: "I thought Manny handled it better than someone with some experience [would]," he said. "It was also a good experience for him to have. He cares. It's a learning experience for all of us."
And what, Buck, have we all learned? That throwing bats that actually hit people is something less experienced players do? That because no one took a bat to the face, baseball's policing system works?
Or maybe it's that in the last three days the actions of your third baseman have set into motion things that clearly expose baseball's unwritten rules as the esoteric, hypocritical, destructive mess they really are, and, instead of breaking from what isn't working, it would rather close its eyes and pretend all is well.
While I do blame Machado for taking it this far, he didn't build the machine that assures team's mutual destruction. The players of today are victims of the players of the past. They are followers, not originators, hopelessly stuck in whims of those been there before players.
The reason this past weekend got out of hand is the same reason you can bet future games between the O's and A's will get out of hand. It's the same reason a game between anyone in this game will get out of hand: because baseball is hopelessly shackled to its eye for an eye style of justice, even when that puts the whole world on the DL over one man's mistake; because baseball will pridefully rationalize its right to pridefully rationalize; because the only thing baseball agrees on is that everyone must be taught to respect a set of rules no one can agree on.
And I'll give you four guess on how it's going to teach that respect. If you manage to dodge all four, you win a free trip to first base.
* * *
Dirk Hayhurst is a former pitcher who spent nearly a decade in professional baseball between MiLB andMLB. He is also a best-selling author, and has appeared on Baseball America, Bleacher Report, Deadspin, The Score, ESPN, TBS' MLB postseason broadcasts, Sportsnet Canada and more. More from Dirk atwww.dirkhayhurst.com. Follow him on Twitter at @thegarfoose.


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Our craftsmanship and dedication to the construction of every home that we build can been seen throughout Kingston and the surrounding areas. We have been building custom fine homes for over 25 years.
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Let Marques Homes build you and your family a prestigious new home customized to your lifestyle! Experience total confidence and support with the staff and trades of Marques Homes.
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We all know how important it is to make off-site back-ups of our genealogical data. Watched the news this past weekend? Did you see what's left of the Dallas Cowboys practice facility in Irving, Texas after a fierce storm and microburst winds hit the structure? Well, that same storm came through my neighborhood only about 20 minutes before it hit Irving. I was headed to Sonic for my daily Dr Pepper fix and suddenly found myself in the middle of 50-mile-per-hour winds, heavy rain and marble-sized hail. I'm talking very sudden! In about 5 minutes the weather went from cloudy but calm and dry to severe storm with lightening, hail, high winds and lots of rain. Fortunately, my house is a bit sturdier than the Cowboys house. The point is, things happen! Weather, hard drive crashes, thieves… it can happen. Don't wait until after the disaster to wish your data was safe!
I have my genealogy data backed up on an external hard drive and also a USB thumb drive. Ok. But I also want it "in the clouds", online somewhere, to be extra safe. Also so that I can access the data if I'm somewhere and don't have my thumb drive handy.
I have been slowly uploading my images to My Picasa Web Album. I've been uploading them as I "complete" each surname study. A good start, but taking too long. As an example, I have been seriously studying my McBurnetts for a couple of months now, so at that rate it will be years before all my images are in the web album. But that's ok, because the uploading process is part of the investigative process, and I want to be as thorough as possible.
But I still want my data safely online, as soon as possible. Remember, I live in Tornado Alley…
Several months ago, I began reading about Mozy, the online backup service. Sounded good, so I gave it a shot. The service will automatically upload your data, as background activity. Ok. So I signed up for it and the uploading process began. This went on for several days, and my computer was virtually worthless during that time period. I have a 3-year-old Dell 710m Inspiron laptop. Not lightening-fast brand new, but not a dinosaur either. My Internet connection is DSL, usually pretty fast. But while Mozy was doing its thing, my little laptop turned to molasses, it seemed. It took forever just to read the online newspaper! After about 5 days of this sludge, my data was still nowhere near finished uploading, maybe because Mozy kept stopping and restarting. I finally gave up on it. I understand that a big bunch of folks use Mozy and are quite satisfied, but not me. So I just continued with my external hard drive…
Last week, I read a post from Elyse about how she backs up her data using Windows Skydrive. 25 GB free storage is plenty for me! So I went to the Skydrive site and signed up. Simple. I started uploading my data. Simple. The only drawback that I can see with SkyDrive is that you can't upload entire folders, only 1 file at a time. But, hey, it's free. Also there's the Big, Bad Microsoft to deal with. A lot of folks don't like Microsoft and don't trust Microsoft. I personally have never had any problems, but then I don't upload any "sensitive" data, like personal financial stuff. But to some, Microsoft is a stigma.
Overall, I was pleased with SkiDrive. Slow, but secure.
Then a comment from Bobby mentioned ADrive. 50 GB free storage, and the ability to upload entire files or directories. So off to ADrive I went. I read through the site and was impressed. My entire My Documents is only 17 GB, mostly digital photos, and the genealogy folder is 2.4 GB, so 50 GB is more than plenty. I signed up and began setting up my storage system. I created folders mirroring my hard drive organization, so everything is easy to find. My biggest folder within my genealogy folder contains about 800 images of family that my uncle gave me. Most of these photos are from about 1960 forward. Not many really old pix, but still valuable. I set that to upload last night before I went to bed, and when I got up this morning, the upload was just finishing.
Here's what my files look like:
My plan is to set the upload every night before I go to bed. I'll let you know how long the entire process takes.


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Updated November 2013
Genetic engineering, or genetic modification, uses a variety of tools and techniques from biotechnology and bioengineering to modify an organism's genetic makeup. Transgenics refers to those specific genetic engineering processes that remove genetic material from one species of plant or animal and add it to a different species. Due to the high similarity in genetic sequences for proteins among species, transgenic organisms are able to effectively assimilate and express these trans-genes.
Figure 1: The mule is a common example of a transgenic organism created when a horse and a donkey mate and produce offspring. Image courtesy Wade B. Worthen, Furman University, Biology Department.
The process of creating a transgene begins by isolating the gene of interest from a donor organism or selecting for purchase any of the thousands of known genes from massive online genomic databases. Once the gene is obtained, it is usually altered so it can function more effectively or be expressed more readily in the host organism. That gene is then combined with other genetic elements and introduced into a second organism (the host), at which point it's known as a transgene. A transgenic organism is further defined as one that contains a transgene introduced by technological methods rather than through selective breeding. Hybrids are transgenic organisms created when reproductive cells from two species combine to form a single embryo (e.g., a mule is the offspring of a horse and a donkey); on the other hand, chimeras are created by artificially combining genetic material from two organisms into a single species.
Current Developments
Figure 2: Golden rice (right) compared to white rice. Image courtesy International Rice Research Institute (IRRI) via Wikimedia Commons.
The field of transgenics allows scientists to develop organisms that express a novel trait not normally found in a species; for example, potatoes that are protein rich, or rice that has elevated levels of vitamin A (known as "golden rice").1,2 Transgenics may be also used to save endangered species such as the American Chestnut tree, which is currently being repopulated by Chinese-American chestnut hybrids specifically engineered with a genetic resistance to the chestnut blight—the deadly fungus that nearly decimated native populations in the early 1900s.3
Transgenic combinations may also include plant-animal-human transgenes, such as when the DNA of human tumor fragments is inserted into tobacco plants in order to develop a vaccine against non-Hodgkin's lymphoma.4 Researchers have similarly developed a flu vaccine using human DNA and tobacco plants.5 Other transgenic plants have been used to create edible vaccines. By incorporating a human protein into bananas, potatoes, and tomatoes, researchers have been able to successfully create edible vaccines for hepatitis B, cholera, and rotavirus, the latter of which can cause fatal bouts of diarrhea.6
Another recent transgenic plant project, known as the "glowing plant project," incorporated a gene from a firefly into a houseplant, creating plants that display a soft illumination in the darkness. One of the proposed goals is to create trees that could illuminate streets and pathways, thereby saving energy and reducing our dependence upon limited energy resources; however, the public release of such plants has sparked a heated debate centered around potential environmental impacts of introducing highly genetically engineered plants into natural ecosystems.7
BioSteel® is a high strength, resilient silk product created by inserting the genes from a silk-spinning spider into the genome of a goat's egg prior to fertilization.8 When the transgenic female goats mature, they produce milk containing the protein from which spider silk is made. The fiber artificially created from this silk protein has several potentially valuable uses, such as making lightweight, strong, yet supple bulletproof vests. Other industrial and medical applications include stronger automotive and aerospace components, stronger and more biodegradable sutures, and bioshields, which can protect military personnel and first responders from chemical threats such as sarin gas.9
Figure 3: Pigs may serve as a valuable source of organs and cells for transplantation into humans. Source: Impactlab.net.
Genetic engineering and transgenic combinations represent a significant aspect of current biotechnology research. Other examples include:
Xenotransplantation, or the transplantation of living tissues or organs from one species to another, is often seen as a potential way to alleviate the shortage of human hearts and kidneys. Pigs have a similar physiology and organ size, making porcine (pig) organs ideal candidates for transplantation into human recipients. Researchers are also exploring the use of cell transplantation therapy for patients with spinal cord injury or Parkinson's disease.
Genetic manipulation of stem cells now includes the growth of tissues on a scaffolding, or a 3-D printer, which then can be used as a temporary skin substitute for healing wounds or burns. Tissue engineering is becoming a viable alternative in procedures that involve replacement of cartilage, heart valves, cerebrospinal shunts, and other organs.10
Commercial companies are deriving therapeutic proteins, such as monoclonal antibodies, from the milk of transgenic cows, goats, rabbits, and mice, and using them to administer drugs in treatment protocols for rheumatoid arthritis, cancer, and other autoimmune disorders.11,12
Clearly, genetic engineering and transgenics represent fields with myriad potential practical applications that are of value to patients and physicians, as well as potentially lucrative research and innovation streams for commercial and industrial consideration.
Ethical Issues
Transgenic biotechnology presents an exciting range of possibilities, from feeding the hungry to preventing and treating diseases; however, these promises are not without potential peril. Some of the issues that need to be considered are the following:
Social Concerns
If the blending of animal and human DNA results, intentionally or not, in chimeric entities possessing degrees of intelligence or sentience never before seen in nonhuman animals, should these entities be given rights and special protections?
What, if any, social and legal controls or reviews should be placed on such research?
What unintended personal, social, and cultural consequences could result?
Who will have access to these technologies and how will scarce resources—such as medical advances and novel treatments—be allocated?
Extrinsic Concerns
What, if any, health risks are associated with transgenics and genetically modified foods?13
Are there long-term effects on the environment when transgenic or genetically modified organized are released in the field?
Should research be limited and, if so, how should the limits be decided? How should the limits be enforced nationally and internationally?
Intrinsic Concerns
Are there fundamental issues with creating new species?
Are species boundaries "hard" or should they be viewed as a continuum? What, if any, consequences are there of blurring species boundaries?
Are chimeras and transgenics more likely to suffer than "traditional" organisms?
Will transgenic interventions in humans create physical or behavioral traits that may or may not be readily distinguished from what is usually perceived to be "human"?
What, if any, research in genetic engineering should be considered morally impermissible and banned (e.g., research undertaken for purely offensive military purposes)?14
- Will these interventions redefine what it means to be "normal"?
The Issue of Species Boundaries
Some individuals argue that crossing species boundaries is unnatural, immoral, and in violation of God's laws, which presumes that species boundaries are fixed and readily delineated.15 However, several books and journal articles demonstrate that the concept of fixed species boundaries continues to be a hotly debated topic.16,17 Some bioethicists point out that a variety of species concepts exist: biological, morphological, ecological, typological, evolutionary, and phylogenetic, to name a few.18,19 All of these definitions of what a species is reflect both changing theories and the varying purposes for which individuals conceptualize and utilize different species.20 If species boundaries are simply a matter of a naming convention, and there are no truly fixed boundaries to cross, then many philosophical objections to transgenics are rendered less problematic.
Figure 4: Many plants and animals form hybrids in nature. Should these hybrids be considered separate species? Copyright 2013 by The University of California Museum of Paleontology, Berkeley, and the Regents of the University of California. Used with permission. Source: http://evolution.berkeley.edu/evolibrary/article/evo_41
While the morality of crossing species boundaries reflects differing worldviews and is subject to disagreement there are, however, several known risks associated with the transplantation of cells or organs from animals to humans. For example, there is a small but significant risk of the transmission of usually fatal zoonotic diseases, such as bovine spongiform encephalopathy (aka "mad cow disease"), porcine endogenous retroviruses (PERVs) and Nipah encephalitis.21 The introduction of these diseases to the human population could have devastating consequences. As a result, the U.S. Food and Drug Administration (FDA) has banned xenotransplantation trials using nonhuman primates until the procedures have been adequately demonstrated to be safe and until ethical issues have been sufficiently publicly discussed. However, with the advent of stem cell tissue engineering and 3-D printing, xenotransplantation may quickly become outmoded, opening the doors to more complex social, ethical, and legal issues and discourses.22
Figure 5: Genetically modified crops (or GMOs) may pose long-term risks to the environment, such as damage to cultivated foods and non-target organisms, or large-scale ecological shifts. Image source: OneGreenPlanet.org.
In addition to the issue of species boundaries, there are other issues that need to be considered and discussed prior to large-scale acceptance and usage of transgenics and other genetic engineering research, including:
- the risks and benefits of the experimental use of animals;
- the risk of creating new diseases—for which there is no treatment—by combining animal DNA or human DNA with plant DNA;
- the potential long-term risks to the environment;
- the potential for increased suffering of transgenic organisms. Various bioethicists, environmentalists, and animal rights activists have argued that it is wrong to create animals that would suffer as a result of genetic alteration (for example, a pig with no legs) and that such experimentation should be banned.23
The Legal Implications of Transgenics
Several bioethicists have called for a ban on species-altering technologies that would be enforced by an international tribunal.24 Part of the rationale for this ban is the concern that such technologies could be used to create a slave race—that is, a race of subhumans that could be exploited. In April 1998, scientists Jeremy Rifkin and Stuart Newman, who are both opposed to genetically modified organisms (GMOs), applied for a patent for a "humanzee" (part human and part chimpanzee) to intentionally fuel debate on the issues and draw attention to potential abuses. The United States Patent and Trademark Office (USPTO) denied the patent on the grounds that it violated the Thirteenth Amendment of the Constitution of the United States, which explicitly prohibits slavery.25
Although the USPTO has permitted the extensive patenting of bioengineered life forms, the question that was raised by Newman and Rifkin's application is one that will not easily be resolved: What constitutes a person? A genetic definition is not very helpful, given the variability of gene sequences between individuals. A species definition can be controversial, as mentioned earlier.26 If we look to specific characteristics for a definition, we are faced with the fact that humans share many characteristics with primates and other animals—so where do we draw the line?27
If we create a being that has the ability to speak and perhaps even reason, but looks like a dog or a chimp, should that creation be given all the rights and protection traditionally bestowed upon a person? Some bioethicists argue that the definition of "human being" should be more expansive and protective, rather than more restrictive.28 Others argue that more expansive definitions could minimize humanity's status and create a financial disincentive to patenting creations that could be of potential use. The question of whether the definition should be more expansive or restrictive will need to be considered as courts, legislatures, and institutions address laws regarding genetic discrimination.
Figure 6: The International Olympic Committee is one of multiple organizations that have expressed public concern about genetic engineering.
In a similar vein, the medical director of the International Olympic Committee (IOC) has expressed concern that athletes have started employing genetic engineering to get an edge over their competition.29 If individuals are willing to genetically manipulate their children to make them better athletes, then it's likely individuals will be willing to manipulate their children to better looking, more musically inclined, or whatever else might give them an advantage. Opponents of genetic manipulation argue that, by allowing this, we run the risk of creating a race of superhumans, changing what it means to be "normal" and increasing the ever-widening gap between the haves and the have-nots. Proponents of genetic manipulation argue that currently parents can and do give their children advantages by sending them to better schools or giving them growth hormones, and that banning genetic manipulation is a denial of individual liberties. These arguments also reflect the opposing philosophies regarding how scarce resources should be allocated.
Genetic engineering and transgenics continue to present intriguing and difficult challenges for 21st century scientists and ethicists, and education and meaningful, respectful discourse are just the beginning of what is required to tackle such complex ethical issues. Until we as a society or, perhaps, as a global entity can agree on what beings—human or otherwise—are worthy of moral and legal status and respect, we can expect intense cross-disciplinary debate and discussion as new life forms are created through science and medicine.
© 2013, American Institute of Biological Sciences. Educators have permission to reprint articles for classroom use; other users, please contact firstname.lastname@example.com for reprint permission. See reprint policy.


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Hard Times For The Legend
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The Monument of Ferdowsi, the greatest Persian poet, on his memorial square in Tehran, Iran
6 responses
Leslie Hunziker gave props (21 Jun 2011):
wild & cool!
Celina Ortelli gave props (17 Aug 2011):
Tamara Maz gave props (21 Aug 2011):
Interesting composition!
John Linton gave props (13 Oct 2011):
Rockin' JPG's Theme Park (in a most timely way).
Thomas Beckmann gave props (20 Nov 2011):
42 = The meaning of life :-) cool catch.
Kreddible Trout said (20 Oct 2013):
don't panic.
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No, the warehouse differentiates the satellites by part of the preamble in the packet data and scores
We've got users running up to 4 co-located ground stations with the same siteId.
The warehouse is accepting packets again, I did a fix to improve processing within the data
server but the side effect was that it was a little too rigorous at rejecting packets.
The effect was for the Dashboard to back off and caches data. Once we had uploaded the
patch to the data service, a whole load of data arrived within the space of a minute when the r
ejection code was removed! Just fixing up the created times now :-)
We though initially that our one year old was having a tantrum when the sequence number
glitched yesterday evening. We now believe that it was an FC2 reset and that the packet preamble
for few millisconds was using the FC1 code.
Many thanks
Dave, G4DPZ


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Erin Callan, the former chief financial officer of Lehman Brothers, offers this contribution to the work-life balance discussion:
I don't have children, so it might seem that my story lacks relevance to the work-life balance debate. Like everyone, though, I did have relationships—a spouse, friends and family—and none of them got the best version of me. They got what was left over.
I didn't start out with the goal of devoting all of myself to my job. It crept in over time. Each year that went by, slight modifications became the new normal. First I spent a half-hour on Sunday organizing my e-mail, to-do list and calendar to make Monday morning easier. Then I was working a few hours on Sunday, then all day. My boundaries slipped away until work was all that was left.
Inevitably, when I left my job, it devastated me. I couldn't just rally and move on. I did not know how to value who I was versus what I did. What I did was who I was.
I have spent several years now living a different version of my life, where I try to apply my energy to my new husband, Anthony, and the people whom I love and care about. But I can't make up for lost time. Most important, although I now have stepchildren, I missed having a child of my own. I am 47 years old, and Anthony and I have been trying in vitro fertilization for several years. We are still hoping.
Sometimes young women tell me they admire what I've done. As they see it, I worked hard for 20 years and can now spend the next 20 focused on other things. But that is not balance. I do not wish that for anyone.
I've been following Callan for a very long time. Until I read this, I didn't realize how much she regretted about the choices she made with her life. It's quite moving.
It's hard not to wonder how much of this is related to the failure of Lehman Brothers. If her firm had not collapsed, she might have felt different about rising to the upper echelon of Wall Street. Success can often provide at least the illusion of happiness. Or, perhaps, it would have just delayed the recognition of her own unhappiness.
Callan hardly needs advice from me but I'll offer it anyway. She may want to consider that her lack of satisfaction with her life's direction is not a product of the choices she made. Instead, her choices may have been a product of her lack of satisfaction. In my experience, the kind of people who can rise to the level she did at a relatively early age tend to be filling a hole in their psyche, an indistinguishable yearning for something more that is experienced as a kind of pain.
Look at Callan's life. She is obviously very ambitious and capable. Yet she describes her life as almost beyond her control. There are no words of happiness about the success she achieved. Instead, she says she wouldn't wish her life on anyone. And now that she is in a new phase of life, she is still filled with regret, worry and unsatisfied ambition. "We are still hoping," she writes. But she means striving, pushing, trying to escape the limits of the ordinary.
If Callan suffers from this, it's not clear that she wouldn't still feel this kind of profound regret if she had filled that abyss with family life rather than work in the financial sector. This feeling of unease about her place in the world is just a part of who she is.
There's very little that can be done about this. Although perhaps recognition of the permanence of this uneasiness would help her experience it not exclusively as a source of pain.
Follow me on Twitter @Carney


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Thursday, 31 March 2011
March review0 comments Posted by anomaly16 at 23:59
It hasn't been an awesome month for poker, but with contracting all of Feb and most of March I wasn't expecting anything great.
My game has definitely suffered, or at least my perception of it, during my time away from the tables so I'm focussed on getting back to where I was. I am planning to get coaching, but I want that to take my game forward and not use it fix leaks I've developed over the last 2 months so it will be a couple of weeks before I book any lessons probably.
Only 2 months to vegas now, so getting super-excited! I'll be playing 3 WSOP events and 2 events in the Venetian Deepstack series this time (total buyin $4200). I advertised 60% of my action for sale on 2+2 a few days ago and sold out in 40 minutes, even getting an offer to buy 1% of my main event action if I was playing! I think the ME isn't a wise investment for me at this stage but I would love to play it some day. I'll have 1% of Gary's attempt, so that will have to do for this year.


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This blogpost was originally posted in February but is back by popular demand.
Thanks for all your emails and requests.
So, You Have A Child With A Hearing Loss On Your Caseload
First Steps for Speech Language Pathologists
The terms deaf or hard of hearing cover a wide range of conditions and all affect a child's listening ability and interfere with their language, social and educational development. The number of children in neighborhood preschools and auditory-oral private schools is ever increasing. Many of these students will need support from SLPs to succeed in mainstream classrooms.
Starting Points
First, below are facts to stimulate your thinking in order to begin by asking the right questions.
Points to Ponder
• 95% of parents of children with hearing loss are hearing themselves
• The trend is that hearing parents are choosing spoken language options such as Auditory-Verbal Therapy for their children with hearing loss
• Auditory based intervention does not use any visual communication systems
• Children with all degrees of hearing loss can learn spoken language through hearing
• Early diagnosis, aggressive audiological management, contemporary hearing technology is essential
• Audiograms no longer predict outcomes
• Hearing loss is not about the ears? – It's about the brain! We hear with the brain –the ears are just the way in. (www.Carol Flexer.com)
• Children can have sensori-neural, unilateral, fluctuating, and conductive hearing losses. They wear hearing aids, cochlear and baha implants and/or FM systems.
What is Auditory-Verbal Therapy?
According to The Alexander Graham Academy for Listening and Spoken Language, "Auditory-Verbal Therapy facilitates optimal acquisition of spoken language through listening by newborns, infants, toddlers, and young children who are deaf or hard of hearing. Auditory-Verbal Therapy promotes early diagnosis, one-on-one therapy, and state-of-the-art audiologic management and technology. Parents and caregivers actively participate in therapy. Through guidance, coaching, and demonstration, parents become the primary facilitators of their child's spoken language development. Ultimately, parents and caregivers gain confidence that their child can have access to a full range of academic, social, and occupational choices. Auditory-Verbal Therapy must be conducted in adherence to the Principles LSLS of Auditory-Verbal Therapy" (AG Bell Academy, 2012).
Who are Listening and Spoken Language Specialists?
The AG Bell Academy governs the certification of Certified Auditory-Verbal Therapists (LSLSCert. AVT) and the LSLS Certified Auditory-Verbal Educators (LSLS Cert. AVEd).The LSLS certification is awarded to qualified professionals who have met rigorous academic, professional, post-graduate education and mentoring requirements, and have passed a certification exam. Typically, LSLS certified practitioners are licensed audiologists, speech-language pathologists, or educators of the deaf who have the required background, training and experience in listening and spoken language theory and practice with children with hearing loss and their families.
What Do I Need to Know?
Helen Keller once said, "Blindness separates people from things; deafness separates people from people..." Without prior experience it is difficult to appreciate the impact hearing has on basic human interaction and daily communication.
If you have the opportunity to see a child who has graduated from AVT or an auditory-oral preschool first and foremost take advantage of theparents' knowledge. Depend on the audiologist, the AVT's and the hearing itinerant's expertise. In the reference section, there are links to simulations of hearing loss and listening with technology that is insightful. Become familiar with variables that effect hearing such as the impact of noise, distance, room acoustics and equipment malfunctions and ways to manage them. Learn about the child's listening and learning abilities, social needs, and the IEP accommodations.
Classrooms are auditory – verbal environments where LISTENING serves as the basis for learning. Read this brief children's story below. Do you recognize it?
You can read the passage but endings are missing and the words are not distinct. It takes time and energy to figure out the story. This visual simulation is similar to the listening ability of a child with well-fit hearing aids. The small font size represents that sound is perceived more quietly than it is for typically hearing children. The child may 'hear' but not understand what was said because pieces are missing. Do you know the story?
Hearing aids and/or cochlear implants do not restore normal hearing. Students who use hearing aids may not be able to hear all of the sounds of speech even when it is quiet and the speaker is close by. A hearing loss is invisible and therefore it is easy to forget the effort required to attend, learn and participate. Children with language delays or additional learning issues make this even more challenging.
Strategies to Facilitate Listening and Spoken Language
There are many specific and purposeful auditory strategies and techniques used to teach a child who is deaf or hard of hearing to learn spoken language through listening. Here are three of the most basic and effective.
Hearing First!
You Will Lose the Opportunity for Listening.
Talk about pictures, objects and events before you show them.
This will focus the child on listening and reduce visual dependence.
After you show the materials, repeat and rephrase the message.
This provides repetition and allows the child to "connect" the
auditory and visual information.
Sit beside the student close to the child's better ear.
Listening Sandwich
Present information through hearing.
Add VISUAL cues, as necessary
Then, SAY IT again to promote listening. "Put it back into hearing."
Wait Time
Pausing and Waiting!
Allow time for the child to process and attach meaning to what was heard.
Don't rescue too soon!
In summary, I have included numerous references, important videos, printable handouts and a wealth of resource materials. This will enable you to further investigate opportunities for supporting children with hearing loss and their families.
"I am deaf and I can listen, hear and talk!"
So, you want to learn more?
This first step is to view the TED Talks video, Establishing a Sound Foundation for Children who are Deaf or Hard of Hearing. Dr. Karl R. White explains the differences in raising children with hearing loss today versus 35 years ago and the key factors for successful language development.
Next, watch a series of short videos of my friend and mentor, Carol Flexer, PhD, CCC-A, LSLS Cert. AVT, as she teaches on auditory brain development, acoustic accessibility, the listening environment, signal to noise ratio and more in her engaging videos. Be sure to scroll down to see Carol!
Read a post from the ASHAsphere blog entitled, "Auditory-Verbal Therapy: Supporting Listening and Spoken Language in Young Children with Hearing Loss & Their Families" Todd Houston, Ph.D., CCC-SLP, LSLS Cert. AVT.
Investigate the Listening and Spoken Language Knowledge Center a vast site for children and adults with hearing loss, their families and the professionals who support them.
Spend some time at Success For Kids With Hearing Loss where Karen L. Anderson PhD, an audiologist has a wealth of resources including printable handouts regarding the relationship of types and ranges of hearing loss and the impact on listening and learning, social needs, and the potential school accommodations and therapy needs. Be sure to investigate Learning With a HL - Things For the Teacher To Know and Understand
So if you're ready to dig in, order your own copy of 101 FAQs about Auditory-Verbal Practice. It is an excellent resource edited by Warren Estabrooks, the President and CEO of WE Listen International. The book takes the reader on a journey through current theory, practice, and evidence-based outcomes. It offers knowledge, guidance, encouragement and hope for future generations of children who are deaf or hard of hearing, their families and professionals.


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Mark Mitchell, OK.gov
405-524-3468 Ext. 120
Drew Hall, OSF
Oklahoma Increases Transparency Efforts
OKLAHOMA CITY – April 24, 2012 – Data.OK.gov, the state of Oklahoma's online data repository, recently integrated with the federal government's Data.gov site to provide new Oklahoma-specific federal datasets.
Data.OK.gov currently offers 215 datasets created by Oklahoma state agencies in addition to the 5,249 datasets now available from Data.gov. The seamless integration of the two sites is possible because both sites are hosted by Socrata, the Seattle-based company that provides the website's software-as-a-service (SaaS) open data platform.
"The additional access to federal data on Data.OK.gov increases the transparency of our state," said Secretary of Finance Preston Doerflinger. "It brings a level of openness and interactivity with government data that our citizens deserve. It lets them see for themselves where Oklahoma stands and where we rank in relation to other states."
The new federal and Oklahoma-specific federal datasets are located on Data.OK.gov under the Federated Domains subheading in the left navigation. The 'This Site Only' link provides Oklahoma-specific federal datasets and the 'explore.data.gov' link provides federal datasets.
"Locating data from the state and Data.gov portals can be cumbersome due to the abundance of data available," said Alex Pettit, State Chief Information Officer. "Now all data concerning Oklahoma, both state and federal, will be at our citizens' fingertips."
The datasets available on Data.OK.gov and Data.gov enable the public and media to utilize state and federal data in a variety of ways, including:
The state's new online data repository is a product of a partnership between the Oklahoma Office of State Finance, Socrata, a leading provider of open data services for federal, state and local governments, and OK.gov, Oklahoma's official website.
About Socrata
About the Oklahoma Office of State Finance
About OK.gov
- 30 -


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I can picture it just like it was yesterday. Midnight came and went and I was still standing atop the Channel 2 Bridge in the Florida Keys. The current was slowly running east as the new tide was just starting to pick up. Below me was a large pod of tarpon, and I was watching them move in and out of the dark shadows between the footbridge I was standing on and the traffic bridge to the east.
I had been fishing for a few hours and had spent a fair amount of time targeting this pod of fish with no hookups so far. My bait of choice was a nice large, freshly-dead shrimp drifted with as little weight as possible. I knew the fish were seeing my bait as a few of them had shown interest in it, but still would not take.
As the tide began to pick up, I knew that I had to try something different otherwise the skunk is all I would catch on this night. I pulled a spool of 40-pound fluorocarbon out of my bag and replaced the 80-pound leader I had been using with one much lighter. On my next cast, I watched as my bait drifted slowly back towards one of the large shadows lurking beneath the bridge. Sure enough I felt a solid "thunk" on the end of my line. Instantly, I set the hook, and the fish rocketed airborne. I was hooked up to a giant tarpon, and the only thing I need to change was my line.
As a tackle shop owner, I am faced with many critical angling questions every day. One of the most important has to do with fishing line. Think about it. Your fishing line is what connects you to the lure or bait that you are fishing, and it is also what connects you to the fish after it bites. Good fishing line is the life blood of successful anglers.
The problem is that there are so many different types and styles of lines. Sometimes picking the right one can become quite confusing. Walk into any tackle shop along the coast and what do you see? A wall full of monofilament, fluorocarbon, and superbraid. "Which one should I use?" The answer is not simple, as the proper line can vary for the every spot you fish and every technique you use.
Still, I've spent quite a few years fishing in and around Ocean City, and fortunately I've been able to see what works best for other anglers and at the same time figure out what works best for me. So tune in to next week's article, and I will do what I can to point you in the right direction for selecting the best fishing lines for angling around Ocean City.
But for now, let's take a look at some of the reports that have come in from around town this past week.
Sue at "Oyster Bay" reports, "Fishing this week was good on flounder though there's a lot of "shorts" out there. Surf fishing has been mostly small stuff like spot, kingfish, and croaker. Good action for kids with Fishbites or bloodworms. Sharks and big rays for pullage. Route 50 Bridge has had a good bite of bluefish at night and early morning. Sea bass are biting offshore, with catches more flounder. Oceanic Pier has had croaker action with lots of shad at night. Crabbing is still happening. Offshore, still good tuna fishing. We're still getting reports of Norfolk spot in the surf along with catches of kingfish, sand perch, croaker and a rare snapper blue. Anglers are using bloodworms, Fishbite Bloodworms, and little pieces of squid or fresh bunker for these panfish. Lots of big rays and smaller skates whether you want them or not. Sharks are around with the larger ones biting at night. (Sandbar, sand tigers, and duskies are the sharks that anglers are catching and releasing.)"
Captain Jeffrey Grimes of "Helbent Charters" reports, "Mother nature chased us off the water early several times this week but without a lot of rain till late Friday the flounder bite continued to be very good. The folks at Oyster Bay told me they have heard of a good Flounder bite in the East Channel so we started out there and we caught fish on each of our first several drifts. After a while I was not real happy with the water clarity so we moved out to the Commercial Harbor and drifted the end of the incoming tide and we caught fish there on our first several passes. Finally, we moved out into the Inlet right before slack tide and we caught several bigger fish there as well. I kept changing up the baits we were offering and we found different baits worked better at the different locations. In the East Channel frozen shiners and squid strips worked the best. Out by the Commercial Harbor Gulp 3" White Minnow worked the best and in the inlet live minnows worked the best. So what did I learn this week? First, check with your local tackle shop and ask them where the bite is. Second, change up the baits you are using throughout the day."
Oceanic Pier is now open (no fishing license required when fishing on this pier) and anglers are catching lots of flounder but keepers are hard to come by. Friday the pier had three or four keepers but most days anglers are catching one or two keepers. Croaker have also hit the pier more consistently this week. Anglers are catching them by day and also at night. There's been live spot and little sea bass for the kids to catch. Some tautog have been caught at the very end and left hand corner of the pier. At night the shad run was surprising good this week. A few blues and croaker are biting at night. Anglers catch blues and shad on spec rigs."
"Old Inlet" reports, "Plenty of spot on the surf. Good tuna bite in the Poormans. Joe VanSant released a 500-pound-plus blue marlin as well. Heard several reports of good flounder fishing in the bay as well as plenty of small blues. Best striper fishing is at night with all of the heat and boat traffic during the day. Live eels and lures on the incoming tide and floating fleas on the outgoing."
"Bill Sports Center" in Lewes, reports, "Kingfish and croaker were reported from the surf. Flounder are biting on Spec Rigs and Gulp! Yellowfin are biting in the Canyons."
"Lewes Harbour Marina" reports, "Flounder catches have been pretty good for guys who know how to work rough bottom structure. The rocks and sea trees of the Old Grounds between DB and DA Buoys, as well as the rubble of reef sites 9 and 10 have been holding fluke, and savvy fishermen have found that modifications to standard rigging helps them catch more flatties amongst that kind of cover. According to Captain Ricky Yakimowicz, short leaders are the key. He said a 3- to 4-ounce bucktail with a hair teaser on a 4-inch leader about a foot ahead of the jig works well. He mentioned that flukers also had success employing a rig with a sinker as heavy as necessary to maintain contact with the bottom, and a hair teaser hook on a short dropper about 6 to 8 inches above the weight."
Capt. Monty on the "Morning Star" is now fishing for sea bass daily. Call for reservations. 410-520-2076. Here's a summary of his report, "Catches from not-so-much to very fine indeed. Sunday I even had one fellow with more than 20 keeper sea bass. Our special 12-hour trip Saturday started with a couple beautiful seabass and a lost-at-boatside keeper cod — then the day fell in a heap for about four hours. Despite a light rail, I had decided to fish way-out and deep. The current, easy the previous day, was full bore, 16 ounces held bottom only briefly in the strong tidal flow. Amazingly, with almost 20 knots of wind the boat laid to the current on anchor: Typically, I'd not even factor current with that much wind. Mate Mike summed up one part of the boat thusly, 'They only had one tangle, but it lasted four hours.' So we picked along, doing our best with a poor situation. I knew the tide would change. Ripping still, the current finally rolled halfway around the compass. South and settled, velocity lessened. The fish came out of hiding — hungry. On the way home, we had a screaming run of large tuna. Three hundred yards of 80 pound line later, Mr. Murphy laughed as the tuna flipped us a fin and went back to life as a super predator. One of these days. Another fish, summer flounder, answered to twitch-twitch on Sunday. Caught a few up to 4 1/2 pounds on gulps and cut bait with the biggest on clam. Game-on any day."
Captain Victor Bunting on the Ocean Princess reports that he has still been picking up a mix of both keeper and throw back sea bass over the last week. "We are seeing a few more nice flounder coming in and have probably landed a good number of keepers in the last few days. The occasional triggerfish is still making an appearance, but still not as frequently as I would like. I would expect to see a few more of these fish over the next week. All in all we have had more good days of fishing than bad. Make sure you call 410-289-6226 for a reservation if you would like to go fishing."
The "Restless Lady" reports, "Captain Todd and Brandon started out with a very rough ride this morning with a young crew. After feeling bad, the young crew with our friend Matt Defeo of Severna Park pulled through and had a nice catch even though it was rough with 5-6 footers. We were a little north of the Hotdog with a nice catch of yellowfins and three Mahi gaffers. Another charter from July 11, a stop in 40 fathoms had a bite which then suddenly had a 200-pound mako on the end of tuna gear meanwhile the tunas were everywhere five miles away in the Washington. We got there and had nine nice ones … still great fishing for all."
At "Skip's Bait & Tackle Shop" this week, we had some nice weigh-ins. My long-time friend and great fisherman Jack Koslosky came by twice with nice catches. The first time Jack had a 35-inch bluefish that weighed 10 pounds, 9 ounces. The monster blue hit a live spot in the O.C. Inlet. Jack also had two nice flounder that day — 19 ½-incher and 18 ½-incher, both caught in the east channel. The very next day Jack showed up again at the tackle shop with his neighbor Gary Redcay, Gary is also one of O.C.'s top anglers. They limited out on flounder with six nice flatties, 18 inches to 22 inches, all caught north of the bridge on live minnows.
I also had some great charters this past week for striped bass, or rock fish as we call them here in O.C. It's hard to believe that we are catching keeper rock and lots of throw backs in mid-July. This is the latest I've ever caught this many stripers, which proves we now have resident fish staying in the O.C. waters all summer. It also proves that proper management of a species can bring them back from being almost wiped out from being over fished.
All four of our charter boats here at Skip's Charter & Guide service are having awesome fishing, with some of the best fishing we've seen in years. Inshore and offshore fishing is off the hook. Pick up that phone and give us a call and book that fishing trip. We still have openings but their filling up fast. We also have our bay boat running with family flounder trips, plus our fishing, clamming, and crabbing combo charter for just $450 for a half day of family fun. We provide all rods and tackle as well as all the bait, so pack some sunscreen and a few drinks and come on out for a memory-making day on the water.
When you step on the boat, you are stepping on a boat that has over 40 years of fishing and boating experience with some of Ocean City's top captains working for Skip's Charter and Guide Service this year. Give me a call at the tackle shop at 410-289-Fish (3474) or on my cell 410-430-5436 and let's talk fishing.
At the tackle shop we are open 6 a.m.-9 p.m., seven days a week, with a great staff that will answer any questions you may have about fishing the Ocean City waters. If you have a report or pictures you would like in The Dispatch or on www.oceancityfishing.com, email me at firstname.lastname@example.com or email@example.com.
The summer weather is here, and the fishing is smoking hot. So get out there and fish! Who knows? Maybe I'll be writing about you next week.
(Maguire is an outdoor writer and owner of Skip's Bait and Tackle and Skip's Charter and Guide Service in Ocean City.)


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To you, it is just a cage; but to your hamster, it is home. Hamsters are pretty clean little creatures and they groom themselves several times a day. Everybody is familiar with the image of a hamster wiping its face with its paws. Basically, hamsters like to be clean and as the owner, its your responsibility to keep their cage clean. By regularly maintaining your hamster's cage you are ensuring their mental and physical health. Many hamster illnesses, in fact, are caused by contaminants in a dirty hamster cage.
Unfortunately, hamster owners should prepare to clean their hamster's cage every day. You need to remove wet litter, caused by urination, on a daily basis. Remove soiled litter and replace it with fresh litter either every morning or every evening, whatever fits your schedule best. This shouldn't take more than a few minutes so it isn't really much of a burden.
On the other hand, you should clean the entire cage and its contents at least once a week. First, you'll need to give your hamster some place to play while you are cleaning the cage. A hamster ball is a great distraction but many pet owners will plug the bathtub and let their hamster run around. When cleaning the cage, remove all soiled bedding and stale food. Wipe the cage with warm, soapy water and rinse it thoroughly. It's always best to use a mild, unscented soap as hamsters are highly sensitive to the smell.
When you're finished cleaning, you just need to put the bedding back in the cage and reassemble the various parts of the cage including food bowl and water dispenser. Just 20 or so minutes a week is enough to keep a safe, clean, and healthy environment for your hamster.


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by Jennifer Ward Barber
After competing at IRONMAN 70.3 Vineman in July, I took a short break from training and all the nutritional discipline that comes with it. Oatmeal? Try chocolate croissants. Green smoothies? Try cocktails. I returned home needing to recover not only from my race, but from my post-race celebrations as well.
Enter the cleanse. I'd read about juice cleanses everywhere from Vogue to The New York Times, and was eager to test the waters. I found a one-day cleanse that looked appealing and picked up my bag of goodies the day I got home. To offer a perspective from the other end of the seriousness spectrum, I enlisted local pro triathlete, Beth Walsh, who tried a longer cleanse after IRONMAN Cairns in June (where she placed fifth).
But first, the basics.
Why cleanse?
Thankfully, I didn't have to look very far or order expensive bottles from the other side of the country: a small company called Beaming had recently set up shop in my neighborhood, and their One-Day Reset cleanse was the perfect introduction to cleansing.
According to Beaming's in-house expert Natasha McKeon, cleansing can help relieve the liver, colon and kidneys of their load of impurities and reset the body at a cellular level. It also helps kickstart healthier habits by revealing what your current diet is lacking. "You may not realize how depleted you were," McKeon says. "When done right, a cleanse can be life-changing. Instead of counting down the days until you can have a Diet Coke or a piece of pizza, you realize you don't want what you used to crave." She adds that a long-term approach is more about balance than rules, but cleansing can help athletes get back to neutral.
The Mayo Clinic's Katherine Zeratsky echoes McKeon's philosophy. She says there are benefits to overhauling your normal eating habits and purposefully excluding processed foods (and their extra fats and sugars) for a focused period of time.
What to look for
There are many different kinds of cleanses on the market, all offering their own spin on a new and improved you. There's the famous Master Cleanse, the 21-Day Clean Cleanse, the BluePrint Cleanse and countless others. Sifting out the good from the bad is the next critical step for triathletes.
McKeon suggests that the typical juice cleanse—where you drink all of your nutrients—is less than optimal for endurance athletes. Her recommended four-day cleanses include a combination of high-protein, low-glycemic smoothies, soups, cold-pressed juices and raw entrées for dinner. The key is volume: "If you're taking a full four days off training, the four-day cleanse is perfect as-is," she says. If athletes are still training daily, she recommends adding items like avocado, almonds, celery and jicama to support their activity level.
What to watch out for
McKeon says that athletes should be wary of juice cleanses that offer strictly high-glycemic juices. "You need to be wary of these because they cause spikes in blood sugar," she says.
Going too low-calorie can also be dangerous. As an athlete, you need to be able to sustain your energy level, not become starved or deprived. "You need to be consuming something healthy every two to three hours to keep your energy up," McKeon says.
When should you cleanse?
There are a few key times that are optimal for triathletes to embark on a cleanse and, depending on your level, different applications. Below is my take on when and why a cleanse might work for an age-grouper, while Walsh's take is from a professional's standpoint.
Reset after a race: Racing can leave you completely depleted and, after a few days of recovery (eating and drinking what your body craves), cleansing can help you bounce back into training more quickly by flooding your body with energizing nutrients. "After something strenuous like completing an IRONMAN is a great time to detoxify the body," McKeon says. In addition to replenishing electroytes and hydrating, McKeon recommends avoiding processed foods high in sodium and refined sugars and grains. "Go for lots of organic greens and a raw, plant-based protein blend," she says.
→Age-grouper take: "I recovered well calorie-wise from Vineman 70.3, but the one-day cleanse provided a flood of nutrients I'd been missing."
→Pro take: "After something like an IRONMAN it's just good to have all those raw foods and juices in your body. They also offer great anti-inflammatory properties," says Walsh, who is also a coach. Walsh cautions against cleansing before a race, however: "It shouldn't be a last-minute effort to get down to race weight," she adds. "It's not your normal diet and you don't want to mess with that a week before a race."
Kick start a new training season: It's been a month since you crossed the finish line of your A-race, and you're feeling a little stale in both body and mind. Cleansing can offer a physical "reset," launching you back into healthy eating habits and helping to kill cravings. Bringing a new seriousness to your diet can give you a mental boost as you enter a new, more disciplined season.
→Age-grouper take: "It's easy for me to 'let myself go' after a race. The one-day cleanse stopped the spiral and made me realize how much I enjoyed feeling 'clean' and healthy."
→Pro take: "I started my cleanse as I began a new training block, which I might not recommend for other people—I was doing pretty heavy training. You have to make it right for you. I added in some higher-glycemic raw, natural foods to supplement the juices: bananas, raw almonds and avocado. I'd recommend triathletes cleanse at least two weeks before they get back into serious training."
Combat a bad habit: Is that late-afternoon cup of coffee making it hard for you to fall asleep? Having trouble killing that 8 p.m. ice cream craving? Cleansing can flood your body and palate with fresh, healthy foods and help kill the reliance on external stimulants and sugar.
→Age-grouper take: "All it took was two weeks for me to start feeling overly reliant on coffee and, the more I gave into my cravings, the more they spiked. I'd forgotten how much I enjoyed eating fresh foods and had started to feel sluggish and complacent about my diet."
→Pro take: "After shoving gels in my mouth for a whole IRONMAN, I rarely crave sweet stuff—more the pizza and burger variety. The week after I eat whatever I feel like eating and give myself a break before getting back to work. I was really excited to start my cleanse, not because I'd developed a bad habit, but to start to make more conscious choices of what I chose to eat."
While cleansing may not make you feel like a completely different athlete, it's more about making the mental switch to treating your body well as you head into the next training block, and reminding yourself of the variety of healthy foods waiting to help fuel you—and keep you healthy—for the next season's races.
If you're interested in cleansing, there are many options on the market, some better than others. Check out Beaming's raw food cleanses on their website. Experts also recommend Whole 30 (a challenging cleanse for long-term habit resets), Clean Cleanse (an approachable, book-led cleanse) , or The Thrive Diet by former IRONMAN pro triathlete Brendan Brazier, a book that speaks specifically to endurance athletes.


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xray wrote:Rode the Fish, have a Nugget.
Lightwind almost nothing can keep up with the Nugget. To me it was so much more livelier than the Fish as well. Shoots upwind too..
do you ride it in waves? How do you find it compared to the fish? This has been on my mind for some time now
I really liked last years fish for the light stuff and small waves...I had it out in super light conditions and liked it for small waves, but after getting more time on the raceboard I kept on not using it...


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Rhetoric rather than government management dominates discussion over furloughs, spending cuts.
A House hearing on Tuesday, advertised as a discussion on how some agencies are implementing sequestration, focused more on partisan politics than on government management.
Republican lawmakers pressed agency officials on the necessity of furloughs, how much pre-sequester planning they did before the governmentwide spending cuts took effect on March 1, and why they haven't asked Congress for more flexibility in administering the sequester. Democrats argued that Congress was to blame for imposing sequestration, and agencies are simply abiding by the law's restrictions to cut the same percentage across every program, project and activity within the overall budget.
Nobody was happy, least of all the witnesses from the Agriculture Department, Commerce Department and the Federal Communications Commission caught in the political crossfire.
Here's one such exchange from Tuesday's hearing: Rep. Matthew Cartwright, D-Pa: "The whole country understands that it is Congress that writes the laws, and it is the law that mandated across the board cuts, and it's the law that restricts federal agencies from defying Congress' intent in the implementation of across the board cuts."
Rep. Jim Jordan, R-Ohio, speaking to witness David Robbins, FCC's managing director: "Mr. Robbins, when Congress passes a law, does it automatically become the law?"
Robbins: "No, the president has to sign it."
Jordan: "Oh, I forgot, that's an important lesson…Mr. Young [Michael Young, Agriculture's director of budget and program analysis], is that your understanding of how the law works? Once the Congress passes something, that the executive branch, the president has to sign it?"
Young: "Yes, sir."
Jordan: "Mr. Sastry [Hari Sastry, Commerce's deputy assistant secretary for resource management], is that how you understand it works in America, too?" Sastry: "Yes."
Jordan to Sastry: "And to your knowledge, the president signed this law didn't he?" Sastry: "Yes."
Jordan: "Imagine that."
And so it went.
The panel's witnesses, in broad and relatively brief remarks, said they've been planning for sequestration since Congress passed the 2011 Budget Control Act, which required the spending cuts to begin in 2013. Republican lawmakers questioned why agencies had not asked for more flexibility to transfer funds, known in government parlance as reprogramming authority, and asked whether savings could have been found elsewhere to avoid furloughs. "You've had 20 months to get ready for this," Jordan said. House Oversight and Government Reform Committee Chairman Darrell Issa, R-Calif., sent 17 federal agencies a letter last month asking them to identify unnecessary or wasteful agency programs that could be eliminated as an alternative to the mandatory spending cuts mandated by sequestration.
The federal government has to produce $85 billion in spending cuts in fiscal 2013. Agencies have to submit a detailed sequestration plan to Congress by April 1.
Officials stressed the budget-cutting restrictions imposed by sequestration, which requires across-the-board reductions to every program, project and activity within an agency. "With roughly 95 percent of our budget going to our workforce, rent, utilities and contracts, it will be a daunting task to find the $17 million of cuts required under the sequester without adversely impacting our workforce and the mission of our agency," said Robbins, who added that the FCC is doing everything it can to avoid furloughs.
As for Commerce, it has to slash $567 million from its total budget, including $270 million in cuts from the National Oceanic and Atmospheric Adminsitration's budget.
Agriculture has to shave $2 billion from its books during the remainder of the fiscal year. Several programs administered by the Agriculture Department are exempt from sequestration, including the Supplemental Nutrition Assistance Program, or food stamps. Agriculture's fiscal 2012 budget was $151.8 billion -- the 5th largest budget in the federal government.
Agriculture actually has some limited flexibility in managing the cuts, which allows transfers of up to 7 percent among certain accounts within an individual USDA agency. Agriculture Secretary Tom Vilsack said on Tuesday he would use that flexibility to avoid some administrative disruptions regarding certain Farm Service Agency payments. But, according to Young, the extra wiggle room Agriculture has would not negate the expected furloughs of thousands of food inspectors -- a possibility that has riled both Republicans and Democrats. "The interchange authority would not assist [the Food Safety and Inspection Service] in addressing its shortfall because there are no other accounts from which the agency could transfer funds to offset the shortfall," Young said.
Some Republicans looked to find savings in federal pay and compensation. Jordan and Rep. Scott Desjarlais, R-Tenn., both asked Young whether food inspectors receive bonuses, and how much they were worth. Young said that such employees have received bonuses but that he did not know the total amount of bonus money paid out to employees over the past few fiscal years.
Rep. Paul Gosar, R-Ariz., asked officials to calculate the potential cost-savings in their agencies from recalibrating the prevailing wage.
That type of policy granularity notwithstanding, the hearing was largely a public platform for lawmakers to sound off on sequestration.
"When you cut $85 billion out of a budget over a course of seven months, there are consequences," said Oversight and Government Reform Committee Ranking Member Elijah Cummings, D-Md. "Duh."


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Search News
IDB launches dual tranche $1 billion 2-Yr and $1.5 billion 7-Year fixed rate global bonds
Wednesday, July 17, 2019 - 17:38
The Inter-American Development Bank ("IADB" or "IDB"), rated Aaa/AAA (Moody's/S&P), today priced a new dual tranche $1 billion 1.875% 2-year and $1.5 billion 2.000% 7-year fixed rate global bond. The 2-year note pays a semi-annual coupon of 1.875%, matures on 23 July 2021 and priced with a spread of 3bps over mid-swaps and 5.75bps over the UST 1.625% due June 2021, which represents a yield of 1.924% s.a.
IDB announces the finalists for the Superheroes of Development Award
Thursday, July 11, 2019 - 18:59
The Inter-American Development Bank (IDB) today announced the eight finalists for the second edition of its Superheroes of Development Award, which recognizes the innovative solutions devised and valuable lessons learned by executing agencies while implementing development projects in Latin America and the Caribbean.
IDB Issues New Education, Youth, and Employment (EYE) Uridashi Bonds for Naito Securities
Monday, July 8, 2019 - 16:33
The Inter-American Development Bank ("IDB" or "IADB"), rated Aaa/AAA, has priced two Uridashi zero coupon notes for Naito Securities under its Education, Youth and Employment (EYE) Bond Program.
MDB climate finance hit record high of $43.1 billion in 2018
Thursday, June 13, 2019 - 11:26
An increase of over 22 percent on the previous year, boosting projects that help developing countries and emerging economies cut emissions and address climate risks – joint report.
IDB launches US$2.1 billion 2.250% 10-year Fixed Rate Global
Wednesday, June 12, 2019 - 16:54
The Inter-American Development Bank ("IDB" or "IADB"), rated Aaa/AAA (Moody's/S&P),priced a new US$2.1 billion 10-year global bond. The transaction pays a semi-annual coupon of 2.250% and matures on 18 June 2029. Priced with a spread of 12.25 basis points over the UST 2.375% May-29, this represents a yield of 2.270%.
IDB announces selected proposals of its "Bootcamps for Tech Fans" challenge
Thursday, June 6, 2019 - 16:48
Fifty-seven proposals were submitted, and the entities selected will benefit people in Central America, Colombia, Mexico and Venezuela. IDB Lab, the IDB's innovation laboratory, has announced the two proposals selected to implement the best and most innovative Ready-to-Work Bootcamp models aimed at closing the skills gap of our future workforce in Latin America and the Caribbean, especially of people in vulnerable circumstances.
The IDB honors Peruvian chef Gastón Acurio
Tuesday, May 21, 2019 - 17:47
The ambassador of Peruvian cuisine will deliver the Cátedra Enrique Iglesias of Culture and Development on May 21, 2019. The Inter-American Development Bank (IDB) announced today that the chef Gastón Acurio was recognized with the Cátedra Enrique V. Iglesias of Culture and Development. This award was created by the organization to distinguish those who have excelled in their work of promoting the progress of Latin America and the Caribbean through the arts and culture.
IDB Launches GBP 500 Million 1.250% Benchmark Due December 2025
Thursday, May 2, 2019 - 15:27
The transaction pays an annual coupon of 1.250% and matures on 15 December 2025. It priced with a spread of 40 basis points over the 2.000% UKT due September 2025, which represents a reoffer yield of 1.305% annually.
Inter-American Development Bank Prices AUD 500 Million 5-Year 'EYE' Bond
Monday, April 15, 2019 - 13:07
The Inter-American Development Bank ("IADB" or "IDB"), rated Aaa/AAA (Moody's/S&P), priced a new AUD500 million 5-year fixed rate Kangaroo offering under the Education, Youth, and Employment ("EYE") Bond program...
IDB selects CastleOak Securities to its Discount Note Dealer Group
Tuesday, April 2, 2019 - 10:25
To partner with the IDB to broaden the distribution of its debt securities.


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PVT US Army
World War I
December 15, 1895 - February 28, 1973
Contributed on 12/15/08 by mjkane7
Email This Contributor
Record #: 123366
Thank you for visiting the Arkansas Gravestones. On this site you can upload gravestone photos, locate ancestors and perform genealogy research. If you have a relative buried in Arkansas, we encourage you to upload a digital image using our Submit a Photo page. Contributing to this genealogy archive helps family historians and genealogy researchers locate their relatives and complete their family tree.
Submitted: 12/15/08 • Approved: 10/9/09 • Last Updated: 9/14/12 • R123366-G0-S3


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Cajon Latino Birdseye Cherry
This image shows the scope of delivery.
In terms of sound, the Latino Cajones really stand out. This is due to a true separation of the snare and bass sound achieved by a special construction. The top of the front plate offers a rich and precise snare sound created by strands and the bottom features a separated bass sound without sympathetic snare wire buzz.
Regarding visual appearance, the combination of birch body and beech front plate with an elegant Birdseye cherry veneer makes this instrument become an attractive choice.


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Watermark/Logo will NOT be on your print.:
This is a new, reprinted Vintage Image on real art cloth canvas:
The print is on a 11"x 17" REAL CLOTH ART CANVAS with very clear colors.: The images are printed as large as possible to facilitate framing and/or matting. There is at least a minimum of a 1/4" white border..depending on the original size (measurements) of the image.
READ Please, Important Information
: A) All out of US & Canada deliveries take a long time..and can be up to 2 - 3 weeks or more due to CUSTOMS DELAYS B) We ship via First Class Mail US Post is FREE C) Most shipping is within 24 business hours of Paypal D) Out Of US PLEASE GET IN TOUCH FIRST TO FIND OUT THE POSTAGE COST E) Any out of US orders will NOT be shipped unless POSTAGE Payment has been made
Any questions please email to
Payments are with Paypal
Payments are expected within 7 working days of purchase
We ship USPS
Exchanges are accepted, please get in touch regarding proceedure


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Why Being a Lazy Manager Is a Good Thing
"Lazy" typically isn't a word you'd like people to use when describing you, especially in the workplace. But guess what? Being lazy is a good thing! As a manager, you want to help your employees. And that's great — until … r


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Property by
Towns & Villages
Other property in
Offers around £210,000
|Flat 2, Penkiln Bridge Court
Offers over £65,000
|6 Penkiln Mews, Minnigaff
Offers around £39,000
|6 Cumloden Mews
Offers around £59,950
|Tavullia, Penkiln Court
Offers around £175,000
|5 Riverbank
Offers around £150,000
*Under Offer*
7.87 ha agricultural land in sheltered area with vehicular access.
Further Information
If we can be of any assistance with further details of this property or the purchase or sale of any other property, please contact us.
Although prepared with care and believed to be correct, these particulars are not guaranteed and will not form part of any contract. Purchasers should satisfy themselves as to all points.
We have attempted to make our sales details as accurate as possible from the information we have about this property. If there is any point which is of particular interest or importance we would ask prospective purchasers to contact our office and we will endeavour to check the information. We would advise this course of action if prospective purchasers are contemplating travelling some distance to view the subjects of sale.
Where dimensions are quoted, they are approximate only. Heritable systems and appliances are untested and sold as seen.
The photographs used are for the purpose of illustration and may demonstrate only the surroundings. They are not therefore to be taken as an accurate indication of the extent of the property. Also it should not be assumed that the photographs are taken from within the boundaries of the property or show what is included in the sale.
Misrepresentation Act 1967
The particulars on this website do not form part of any contract. Galloway & Ayrshire Properties Limited and its employees or agents is not authorised to warrant the condition of or description of the property on behalf of the seller/landlord. Whilst information and particulars are given in good faith, intending purchasers/tenants must satisfy themselves independently as to the accuracy of all matters on which they rely upon.
12861 - 337 24/08/2019 07:57:56


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(Courtesy of Brybrarobry)
Wednesday, November 18, 2009
Best DUI Ever
Posted by Simon at 2:16 pm
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A blog dedicated to my gorgeous twin boys, my stunning wife and my sport of triathlon.
A thought - "If God invented marathons to keep people from doing anything more stupid, then the Ironman must have taken Him by surprise and Marathon Des Sables must have completely dumbfounded Him"
From the Ironman running rules "1. No form of locomotion other than running, walking OR CRAWLING is allowed"
"Do, or do not, there is no TRY" Yoda. "There is no Spoon" The Oracle


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The Wyndham San Diego Bayside offers stunning views of San Diego Bay and a list of amenities that make it the ultimate city escape. Wyndham San Diego Bayside is steps from the restaurants and nightspots of the Gaslamp Quarter, and close to Little Italy, the Port of San Diego, and the Convention Center.
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