text:
A panel of lawmakers today advanced the nomination of a former legislator and conservative blogger to the Arizona Board of Regents after he promised to scale back and avoid the usually controversial subjects he delves into.
Greg Patterson, who operates and writes the blog Espresso Pundit, said the political website will be going "dark" for some time if his nomination is confirmed.
"I'm going to have it go dark for a month or two and then see exactly what I can talk about and what I can't," he said. "Chances are, it's going to stay completely dark for quite a while."
"I don't want to make it look unprofessional or unseemly to talk about other issues as well … (when) you represent the Governor's Office, you're representing the education community and you're representing a lot of folks," he added.
The move is an apparent attempt to mollify critics and provide assurances to supporters who may be wary of him blogging on controversial topics — and criticizing policymakers or their ideas — while he serves as a regent.
Later, when Sen. Jerry Lewis, a Republican from Mesa, asked what his blog would look like when he resumes it, Patterson indicated it would be far from the kinds of things he weighs in on today.
He might write, he said, about the questions that perplex children, such as why, for example, Phoenix Sky Harbor International Airport has terminals 2, 3, and 4—but not a terminal 1.
The committee approved his nomination by a vote of 6-1.
Senate Minority Leader David Schapira, the only Democrat present, voted "no."
As expected, Schapira tried to take Patterson to task for his views and his blog posts, which in the past have included criticisms of tuition increases and of university presidents.
They discussed, at length, the nominee's critical views on universities' liberal arts programs and a blog post he wrote about what he would tell students if he conducted the freshmen orientation.
In the blog post, he wrote: "While one or two of you may become Rhodes Scholars or CEO's — some of you will also become homeless or go to prison."
The title of the post is "Here's why they don't let me conduct orientation."
Schapira thought the remark was disparaging to students.
But the Republicans on the committee said they appreciated Patterson's candor and honesty.
Students need to have a "reality check," said Sen. Lori Klein, R-Anthem.
Patterson zeroed in on one point: university degrees should lead to jobs. Otherwise, you'll see the kinds of frustration expressed in the Occupy Wall Street movement, he said.
During the next hour, Schapira pressed and Patterson answered.
It was a measured, civil, intense and entertaining debate.
To explain his position, Schapira read from an Arizona Republic editorial against Patterson's and voted "no."
The full Senate still needs to confirm his nomination.


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April 23, 2013
Federal Court Orders Wisconsin Resident Eric N. Schmickle and his Company, Q Wealth Management Inc., to Pay over $5 Million in Restitution and a Civil Monetary Penalty for a Multi-Million Dollar Commodity Futures Fraud
In a related criminal action, Schmickle pleaded guilty to wire fraud and was sentenced to 36 months in prison
Washington, DC – The U.S. Commodity Futures Trading Commission (CFTC) today announced that it obtained an Order requiring Defendants Eric N. Schmickle, of Cedarburg, Wisconsin, and his company, Q Wealth Management Inc., to pay approximately $3.6 million of restitution and jointly to pay a $1.5 million civil monetary penalty in connection with operating a commodity futures Ponzi scheme (see CFTC Press Release 6362-12, September 26, 2012).
The Consent Order for Permanent Injunction, entered on April 19, 2013, by Judge Rudolph T. Randa of the U.S. District Court for the Eastern District of Wisconsin, also imposes permanent trading and registration bans against the Defendants and prohibits them from violating the Commodity Exchange Act and a CFTC Regulation, as charged.
The Order finds that, from May 2009 through approximately April 2012, Schmickle operated a fraudulent commodity futures scheme through two entities: Q Wealth Management Inc., a Commodity Trading Advisor, and Aquinas SF LLC, a Commodity Pool Operator. Through these entities, Schmickle solicited approximately $5.2 million from one managed client and ten pool participants. Of those customer funds, Schmickle lost more than $2.9 million in trading and fees and misappropriated approximately $647,000 for his own personal benefit.
The Order further finds that to perpetrate the fraud, Schmickle fabricated and issued false account statements and tax forms that showed fake investment gains, instead of the actual losses. In addition, Schmickle sent invoices to the managed client, charging that client for commission on fake investment gains, according to the Order.
In a related criminal proceeding, on August 31, 2012, Schmickle pleaded guilty to wire fraud, and on February 26, 2013, Judge Randa sentenced him to 36 months in prison (see United States v. Schmickle, No. 12-cr-149 (E.D. Wis. Mar. 12, 2013)).
The CFTC appreciates the assistance of the U.S. Attorney's Office (Eastern District of Wisconsin) and the Federal Bureau of Investigation (Milwaukee Division).
The CFTC Division of Enforcement staff members responsible for this case are David Chu, Mary Beth Spear, Ava Gould, Scott Williamson, Rosemary Hollinger, and Richard Wagner.
Media Contact
Dennis Holden
Last Updated: April 23, 2013

subset: commoncrawl


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You've all heard the claim that we aren't really atheists, we are just mad at god. (Or you will see such things as "so and so claims to be an atheist.")
Today, though I saw an argument in chat with a theist, and someone else's account of an argument they had out in public, and I stopped to wonder if maybe we aren't sometimes encouraging this line of bullshit, albeit unwittingly.
What happened in both cases was the atheist began recounting all the sorts of horrible things Yahweh is portrayed as doing or believing or commanding. In one case, I saw the atheist say "why should I love god when he won't love me back?"
The problem with this sort of thing is we usually don't take care to phrase our remarks to make it clear that god is a character of fiction. When discussing the misdeeds of Yahweh we tend to fall back on a convention we use when we talk about a fictional character in a book. We refer to him by name and talk as if the guy was real and the book was not fiction, for example, "In George Orwell's 1984, Winston Smith was arrested for thoughtcrime," not, "In George Orwell's 1984, the character Winston Smith..."
We know what we mean, because we both know Winston Smith (or god) is fictitious. But they don't know god is fictitious.
Talking this way with someone who believes the fictional character is real might cause him not to understand you are just following the convention. Your phrasing sounds to him like you accept god as real, he "knows" god is real, so he assumes at some level you think god is real.
What I am suggesting here is that you ever want to bring up how nasty this being is, you make it clear that you don't think he exists, make sure you put "fictitious" (or equivalent) in every other sentence at least, and not let them think for a minute that you assume the existence of god.
Yes I know that when you just said you were an atheist this shouldn't be necessary, but obviously many of these people don't understand atheism in their guts, so don't let their paradigm default you into a "believer but mad at god" box.
Views: 6314
So you're saying that when someone or some group of people is still talking about a god, that is proof that the god exists? Can all those gods really exist at the same time, and each god just has different scriptures written?
Or (again I ask), do you think you believe in the only true god, and everyone else is wrong?
It's not a proof that god exists but it's a proof that we are building in anyway such relationship with him by believing or denying. By the way there is no True god or false one you should attack the idea of his existing,than there is no need to talk about them all.i hope that my poor English does not weakened my argument.
RE: "i hope that my poor English does not weakened my argument."
No, but your poor logic does. No one can have a personal relationship with an imaginary being without the aid of delusion.
@thelonely. I am not denying anything. I just don't believe it.
No god, no allah, no angels, no ghosts - simple really.
I also don't believe in Apollo, Enki, a Babylonian god, or Utu, another Babylonian god, but I have my doubts about Artemis :D
He doesn't have poor logic if you read what he said he said people are building a delusion that they have a relationship with god. archaeopteryx- Why do you need to be so critical or someone who lacks some in english and is trying to participate with a lot of intelligent people.
archaepteryx I know what it is like to try to speak a second or third language so I have to call you an a++hole for your unnecessary criticism.
First of all Molly, I lived in Mexico for six years with only a High School (Castillian Spanish) background, so I know as well as anyone how it feels to try to navigate with only a bare grasp of a language, and Lonely speaks FAR better English, than I did Spanish when I first went to Mexico.
Secondly, if you've been following the conversation between Lonely and myself, you will have noticed that I have bent over backward to let him know that his grasp of English is not a problem with me, it's the premise that he begins each post with, that there IS a god, with which I have a problem.
Thirdly, as you may notice, you and I have run out of "Reply" buttons, so I'm having to try to find a work-around to put this post where it should be to make sense. Well, Lonely and I ran out of "Reply" buttons as well, and because he didn't know why, he assumed that I had abruptly ended our conversation because I was angry - check our thread and see for yourself! I made it a point to go back in, find a way to place my post under his (just as I did here), so he would be sure to see it, and explained to him that as more and more replies get added to a thread, the text gets narrower and narrower, until suddenly, there are no more "Reply" buttons, and that it had nothing to do with anything I did or didn't do.
You are certainly free to call me anything and everything you like - all I ask, Molly, is that you're doing it for the right reasons.
pax vobiscum,
Sounds like Occam's Razor coming into play.
For believer's its a matter of belief or non-belief in their 'true god"..They've already assumed theirs is the true one and everyone else is wrong, so that's the only one that matters in regards to O.R for them.. Now, as Atheists we expand that to include all gods no matter the religion. That in effect renders O.R. invalid by lowering the odds of any one god being the true one. (2,000+ to 1 aren't good betting odds for anyone..) Therefore, it invalidates O.R. and a belief in a god, while at the same time it validates a stance on Atheism.
I need to correct my reference.. I mean Pascal's Wager, when I mentioned Occam's Razor. No idea how I made that mistake.. LOL
I have memories Lonely, memories that my parents did just as your parents did - they taught me that their religion was the only true religion in the world. But even at that young age, I had access to National Geographic magazines that contained stories of other cultures around the world, who believed in different gods, and I found myself asking why our religion was any better than the others. When I got, "It just is." as an explanation, I began to doubt that my parents had the answer either. The older I got, the more I questioned, and the more I questioned, the more I realized that most people had no idea what was true and what was not, they just believed what their parents believed.
Gradually, through lots of study on the subject, my eyes began to open and I realized that all gods were invented by Man. My memories are still on the server, but my beliefs were overwritten by the facts.
i like when you personalize the discussion, because the idea of believe or not is simply a personnel experience with God it has no relation with science or why you interfere your self when we discussed him. So if we talk about each individual experience with what we called God you will find unlimited experiences.
Personal experiences with an imaginary being involve at LEAST delusions and possibly hallucinations. So you saw the image of Muhammad on a grilled cheese sandwich - who cares?
See, I told you I could be lots more arrogant.


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In 1633, an aging Italian astronomer named Galileo Galilei was taken before the Roman
In 1633, an aging Italian astronomer named Galileo Galilei was taken before the Roman
Inquisition, tried, convicted of heresy, and sentenced to spend the rest of his life in prison.
Galileo's crime? He endorsed the idea, proposed a century earlier by the great Catholic astronomer Nicolaus Copernicus, that the earth is not the center of the solar system. In fact, said Galileo, it is the other way around: The sun sits at the center, and the earth is simply one of a handful of planets that revolve around it.
This idea was judged as being diametrically opposed to the position taken by Holy Scripture. Galileo was forced to publicly recant his views, and his book containing the offending idea, Dialogue Concerning the Two Chief World Systems, was banned. The old man's sentence was later commuted to house arrest, and he lived out the rest of his days confined to his villa outside Florence, where he eventually went blind.
Still, Galileo's views persisted, and the meticulous experiments and mathematical models he used in his search to understand nature set the stage for all the developments of modern science that followed. Three centuries later, a German physicist named Albert Einstein called him "the father of modern science."
For more than a thousand years leading up to the time of Galileo, science had been more interested in creating intellectually satisfying descriptions of reality than in trying to see if those descriptions could be supported by proof. But with the age of Copernicus and Galileo, European scientists began the vigorous pursuit of empirical evidence. Thought experiments gave way to actual physical experiments, such as the famous moment when Galileo dropped two objects from the Leaning Tower of Pisa to test out Aristotle's assertion that heavier objects fall faster than lighter objects. (They don't.)
From Galileo's time onward, scientists' precise observations contributed to a picture of the world that looked very much like a massive piece of mechanical clockwork; they had little practical use for such ideas as soul, spirit, or consciousness. The French philosopher and mathematician René Descartes, a contemporary of Galileo's who is today regarded as "the father of modern philosophy," declared that the best way to understand how the world works would be to divide existence into two parts: the objective or material world, governed by the principles of science, and the subjective world of the mind and the soul, which would be the province of the church.
Descartes is especially famous for the statement I think, therefore I am. But the truth is, the think part of that declaration puzzled Descartes, much as it has puzzled scientists for centuries since. Just how is it that we think? Where do our thoughts come from? How do the bits of physical matter that constitute our brains generate consciousness? As contemporary physicist John Hagelin has said, "There is a deep philosophical problem surrounding how you get consciousness out of a hunk of meat."
Despite Descartes' neat division of reality, common sense suggested that our thoughts must be connected to the rest of existence somehow. But how, exactly? The answers to those questions open up a tremendous new world of possibility for what we can achieve in our lives, and they form a central part of The Answer.
In the generations following Galileo and Descartes, Sir Isaac Newton took the idea of nature-as-machine much further, detailing the precise laws that govern how that machine operates. All of classical physics, and in fact, all of modern science, has been built upon the foundation created by Newton, who described a universe of empty, three-dimensional space, through which physical objects move according to immutable laws. These laws of motion made possible the advance of modern technology, from simple steam engines to the space probes that have analyzed soil samples on Mars.
What we have been able to accomplish by applying Newton's laws has been truly astonishing. But scientists eventually reached the limits of the Newtonian worldview. As their tools grew more sophisticated, their explorations of the physical world took them deep into the heart of the atom, where the nature of reality proved to be something quite different from anything Descartes or Newton ever imagined.
At the dawn of the twentieth century, the tidy, objective, mechanistic view of the world began to fall apart. With the discovery of radioactivity in the late 1890s, scientists began looking into the world within the atomic nucleus, and they were shocked to discover that on the subatomic level, the physical world did not behave at all the way Newton said it should. In fact, the "atom" itself turned out to be a sort of illusion: The closer scientists looked, the less it really appeared to be there.
Coined in ancient Greece, the term atom means "indivisible unit," and through the nineteenth century, scientists believed that our entire physical universe was composed of these elementary particles. But radioactivity showed us that the atom was divisible after all -- in fact, there was a whole new world of phenomena inside the atom, waiting to be explored, measured, and described. And when our vision of the atom fractured, the foundation of classical physics fractured along with it. Our view of how the world works was in for a radical transformation.
When we say the name Albert Einstein, what comes to mind? Perhaps you think of his wild mane of white hair, or that famous picture of the distinguished physicist sticking out his tongue. Or maybe you think simply, "Genius." But whatever picture you have, you will also probably come up with "E=MC2." Why on earth would a mathematical equation for a sophisticated theory be so famous that even nonscientists recognize it immediately? Because with that simple equation, "Energy equals mass times the speed of light squared," Einstein shattered centuries of thinking and radically altered our view of how the world works.
In his effort to explain the puzzling behavior of light, Einstein found the only viable solution was to stop looking within the neat framework of Newtonian physics. Instead, he introduced his own picture of how the world works: the theory of relativity. One reason Einstein's idea was so transformative was that for the first time ever, it described how energy and matter are not only related, but can be transformed back and forth into each other. A chink had been found in the wall separating the worlds of matter and energy. Now the elegant, clear-cut world of classical, Newtonian physics would be forced to move over and make room for the fuzzy, strange, nearly unimaginable world of quantum physics.
Quantum physics is the study of how the world works on the smallest scale, at a level far smaller than the atom. And as scientists studied the nature of reality on a smaller and smaller scale, something strange began to happen: The deeper we went into reality, the more it seemed to dissolve from view. The search for the smallest known particle of matter had instead turned up distinct yet elusive little packets of energy, which physicists called quanta.
The Einstein breakthrough comes down to this: Everything is energy. A rock, a planet, a glass of water, your hand, everything you can touch, taste, or smell -- it's all made of molecules, which are made of atoms, which are made of protons and electrons and neutrons, which are made of nothing but vibrating packets of energy.
This is where quantum physics intersects with what I found inside that cardboard box. What physicists found has everything to do with how you are going to create the life of your dreams by building your dream business. For once we know that everything is energy -- that there is no absolute distinction between matter and energy -- then the boundaries between the physical world and the world of our thoughts start to disappear as well.
In the decades that followed Einstein's theory of relativity, the new quantum physics began to reveal some very strange things. The tiny packets of energy known as quanta exhibited some very peculiar behaviors, including an unexplainable ability to influence one another, a property called entanglement.
In his book Science and the Akashic Field, physicist Ervin Laszlo describes a series of experiments conducted by lie detector expert Cleve Backster. Backster took some white blood cells from the mouths of his subjects and cultured them in a test tube. He then moved the cultures to distant locations, more than seven miles away. He attached lie detectors to the cultures and then performed a series of experiments on his subjects.
In one of his tests, he showed his subject a television program depicting the Japanese attack on Pearl Harbor in 1941. This man was a former navy gunner who had actually been present at Pearl Harbor during the attack. When the face of a navy gunner appeared on the screen, the man's face betrayed an emotional reaction -- and at that precise moment, the lie detector's needle seven and a half miles away jumped, exactly as it would have had it been attached to the man himself, and not just to a test tube of his cultured white blood cells miles away.
Subsequent experiments varied the circumstances and increased the distances involved to dozens and even hundreds of miles, with the same astonishing results.
How is such a thing possible? In the language of quantum physics, the particles of the gunner's body are still connected or "entangled" with one another, and no matter how far apart they are separated in space, they will continue to influence one another. In fact, this effect appears to occur at speeds faster than the speed of light, which violates one of Einstein's basic rules.
Scientists dubbed this mind-boggling capacity for instantaneous interconnection nonlocality. Einstein had a somewhat less technical term for it. He called it spooky action at a distance.
What could this force be? Could it be something even more basic than energy? The search was on for an underlying force that could bring together all the different kinds of energy we knew. This quest for a single mathematical equation that would account for the behavior of all the known forces in the universe -- a unified field theory, or "theory of everything" -- has become the holy grail of science. Some leading astrophysicists, such as Stephen Hawking, say that when we come up with this theory of everything, we will know the mind of God.
Within twenty years of Einstein's radical work, another revolution in worldview occurred, just as cataclysmic as Einstein's. It started with two of the early pioneers of the quantum world, the Danish physicist Niels Bohr and his protégé Werner Heisenberg.
Bohr and Heisenberg studied the puzzling behaviors of these tiny subatomic particles and recognized that once you look deep within the heart of atoms, these "indivisible particles" are not at all like the neat little miniature solar systems of billiard balls everyone had expected, but were something far messier: They were something like tiny packets of possibility.
Each subatomic particle appeared to exist not as a solid, stable "thing," but as the potential of any one of its various possible selves. Heisenberg's uncertainty principle stated that it was not possible to measure all of a subatomic particle's properties at the same time. For example, if you record information about the location of a proton, you cannot pin down its speed or trajectory; if you figure out its speed, now its precise location eludes you.
Bohr and Heisenberg's work suggested that at its most basic level, physical matter isn't exactly anything yet. At the subatomic scale, according to this new understanding, reality was made not of solid substance but of fields of potentiality -- more like a set of possible sketches or ideas of a thing than the thing itself. A particle would take on the specific character of a material "thing" (in the scientists' terms, its properties would collapse into a single state) only when it was measured or observed.
And that was the really strange thing: the discovery that the act of observation influenced these particles' behavior.
Every time the scientists looked for an electron, an electron would appear, right where they were expecting it. And it didn't matter if the person performing the observation was a scientist or a bus driver. In fact, even more bizarre, it was soon found that the mere intention of measuring particles, even without carrying out the actual act itself, would still affect the particles in question!
Suddenly subjectivity -- the action of consciousness upon a piece of "matter" -- had become an essential component in the very nature of reality.
As scientists continued pursuing their explorations on staggeringly small scales, they eventually found themselves staring at something truly confounding. They termed it the zero-point field (ZPF), because at this most infinitesimal of levels, some sort of force appears to be present even at a temperature of absolute zero, when all known forms of energy vanish.
This is the place where the instantaneous connections of entanglement -- those action-at-a-distance phenomena Einstein termed spooky -- begin to make sense. Here, beneath the level of energy itself, exists a still more basic level. The field at this level is not exactly "energy" anymore, nor is it a field of empty space. It is best described, physicists realized, as a field of information.
To put it another way, the undifferentiated ocean out of which energy arises appears to be a sea of pure consciousness, from which matter emerges in clustered localities here and there. Consciousness is what the universe is made of; matter and energy are just two of the forms that consciousness takes.
Ervin Laszlo calls this field that underlies and connects all things the A-field, in deference to the ancient Vedic concept of the Akashic record, a nonphysical repository of all knowledge in the universe, including all human experience. The psychologist Carl Jung called it the collective unconscious; Teilhard de Chardin dubbed it the noosphere; Rupert Sheldrake refers to it as the morphogenetic field. It has been intuited and described for thousands of years and in a multitude of terms and images throughout human history. Only in the last few decades has science caught up to what we always sensed but could never fully explain.
Says Laszlo: "The ancients knew that space is not empty; it is the origin and memory of all things that exist and have ever existed....[This insight] is now being rediscovered at the cutting edge of the sciences [and is emerging] as a main pillar of the scientific world's picture of the twenty-first century. This will profoundly change our concept of ourselves and of the world."
In fact, it has already profoundly changed our picture of ourselves and our world -- and it will radically change how you approach your business.
So what are we saying here, that everything that is, is made of thought? That thought creates the physical world? Yes, that is exactly what we're saying. Here, in a nutshell, is the conclusion so far of humanity's epic quest to understand the world:
Everything in the physical world is made out of atoms.
Atoms are made out of energy.
And energy is made out of consciousness.
Your thoughts not only matter, they create matter. Thought is where everything comes from. And your thoughts are where your business comes from.
If all this seems difficult to grasp or accept, imagine what it must have seemed like to the people of Galileo's time when they were asked to consider the proposition that the earth travels through space around the sun. To the ordinary citizen of the sixteenth or seventeenth century, it was so patently obvious that the earth stood still that the matter didn't even warrant serious discussion. After all, if we were shooting through space, why weren't we blasted by hurricane-force winds? "Besides, any fool can see that the earth isn't hurtling through space: We're just standing right here!"
Or travel back a few thousand years further, to antiquity, when the world was generally perceived to be flat. "Of course the world is flat! I mean, aren't you going to believe the evidence of your own eyes?"
So it is with the discoveries of modern physicists. Anytime our view of the world shifts radically, things seem uncomfortable, strange, bizarre, surreal. Even impossible.
"The world, round?" "So you're saying the earth moves, that it orbits the sun -- not the other way around?" "Matter and energy are actually the same thing? You mean, matter is made of energy?" "What, now you're saying that matter and energy and everything in our world is made of thought? And our thoughts actually influence the formation of matter?!"
Yes, indeed, this seems surreal. But to pre-Socratic philosophers, so did the idea of a spherical earth. The truth is, we don't see what is there. We see what we are prepared to see, what we are conditioned to see.
There is a story that when Magellan's expedition first arrived on the shores of Tierra del Fuego in 1520, the native canoe-going population didn't mount much of a response, because the vast European sailing vessels represented such an alien concept that they literally could not see them. Like Captain Kirk and Mr. Spock and the rest of the team of the USS Enterprise stepping out of their invisibility-cloaked spaceship, the foreigners seemed to the natives as though they stepped out into their smaller canoelike landing craft literally out of thin air.
You've heard the old expression "I'll believe it when I see it." But that's not really how it is. The truth is more like this: You'll see it when you believe it. In a very real, concrete sense, your beliefs don't simply reflect your reality, they create your reality -- and that applies to the reality of massive success in business. In the chapters that follow, we're going to walk through the process, step by step, of building your dream business by first harnessing the most powerful force in the universe: your beliefs.
If the idea that the universe is made of thought seems amazing, here is the truly amazing thing about it: The scale of power we're talking about here is staggering beyond comprehension.
The universe appears to be structured as a series of layers or levels, much like an onion or Russian nesting dolls: Inside of organisms, we find cells; inside cells, molecules, then "indivisible" atoms, then electrons and protons, then quarks, bosons, mesons, photons, leptons...and the smaller the world, the greater the amount of force we find wrapped inside it.
The deeper in nature you go, the more dynamic nature becomes. In other words, the more fundamental the level to which you penetrate, the greater the power you'll find.
For example, chemical power, the force of chemical interactions, operates at the level of molecules and atoms. Nuclear power operates at the level of the atomic nucleus, about a million times smaller -- and it is a million times more powerful. Yet even the nuclear level pales in comparison to the deeper levels today's quantum physics is exploring. According to Laszlo, the zero-point field has an energy density of 1094 ergs per cubic centimeter -- that's ten thousand billion, billion, billion, billion times more energy in a single cubic centimeter of "empty space" than you have in all the matter in the known universe.
And that's just one cc of empty space. Imagine what you'd have in a quart.
In 1902, two years after the physicist Max Planck first coined the term quantum to describe the core reality of light, a young British writer named James Allen penned a little book entitled As a Man Thinketh, which drew its title and its message from the biblical verse "As a man thinketh in his heart, so is he." At the time, few would have associated the two men and their work, but with the hindsight of a century's discoveries, we can now see the connection. While scientists spent the rest of the century pursuing the horizon set by pioneers such as Planck, Einstein, Bohr, and Heisenberg, which would ultimately lead to the quantum vacuum, philosophers like Napoleon Hill, Earl Nightingale, and Bob Proctor worked to articulate its application to the practical world of human accomplishment.
This idea, that our thoughts have a direct, causal impact on our reality, has been observed, but it always seemed like something that rational people couldn't buy into, an idea that created more questions than answers. Now science has given us that set of answers.
Remember the mind-boggling amount of power in that cubic centimeter of "empty space," or consciousness? When Victor Hugo said, "There is nothing more powerful than an idea whose time has come," we now know that this was more than a metaphor. He may not have fully realized it at the time, but he was giving us a literal description of how reality works.
Thought is the most powerful force in the universe. Our thoughts are the controlling factor in what we manifest and create in our lives.
The idea precedes the thing.
That is at the heart of how my dream house showed up, as well as every business I've built, and the same thing happens to every businessperson who has a vision and applies these strategies and tactics. It started as a picture, an idea in my mind, and before I knew what had happened, I was living in it.
Science tells us that underlying what we know as the world is a field of pure consciousness, billions upon billions of times more powerful than any measurable energy, and that this field of absolute consciousness knows everything that happens, anywhere and everywhere in the universe, instantaneously and with absolute accuracy. This is not so different from the kind of descriptions people have given for millennia in their efforts to grasp the ultimate nature of our universal source, what some of us call God. Whatever you call it, the picture that emerges is of a world bounded by an infinitely large, omnipotent, omniscient intelligence, which lies behind everything in the phenomenal world as its source, author, and ultimate destination.
This is the dream world we live in, you and I, and it is the clay from which you will shape and give life to your dream business.
Reprinted with Permission
Copyright © 2008 by Ria Ventures, LLC, and Murray Smith


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|2012-09-08, 00:27
|Link #1042
True Harem End or BUST
Join Date: Oct 2010
|2012-09-08, 02:01
|Link #1043
Join Date: Aug 2011
Location: Kharkiv, Ukraine
Age: 31
|2012-09-08, 03:44
|Link #1044
Join Date: Dec 2008
Age: 29
|2012-09-08, 04:02
|Link #1045
Anime-Only Viewer
Graphic Designer
Join Date: Apr 2006
Location: USA
Actually, when I think about it, the anime title has 3 elements:
1) Love
2) Election
3) Chocolate
Originally, I thought that these 3 subjects blended together, which would result in Chisato. However, after seeing these past episodes, I now realize that they are 3 distinct subjects that are not necessarily blended together. Yuuki has the "election" to win to save the club. That has a lot of focus. He also has to deal with "love", which does not necessarily relate to the elections. Finally, he will have to deal with "chocolate".
If we look at it this way, chocolate definitely and solely belongs to Chisato. If Chisato belongs to chocolate, the elections belong to Isara and Mifuyu (who helps him out/influence him the most), then that leaves love left. Therefore, love will probably not be in store for Chisato, and the likely candidates are Satsuki and Michiru. Satsuki for obvious reasons; however, the reason why I included Michiru is because she, so far, does not fit with either "election" or "chocolate".
Btw, I did not include Satsuki in "elections" because her influence on Yuuki has been mostly as a lover, not political assistance.
|2012-09-08, 04:17
|Link #1046
Senior Member
Chisato has her good points, to be sure, but a lot of guys would flee in terror from a girl like this, lol.
It's a shame that she's as prone to jealousy as she is, because she's otherwise one of the better tsunderes I've seen.
Spoiler for minor game comparison:
|2012-09-08, 04:24
|Link #1047
reading #hikaributts
Join Date: Feb 2009
Spoiler for Game Comparison:
Last edited by relentlessflame; 2012-09-08 at 06:55. Reason: Comparisons must be behind spoiler tags
|2012-09-08, 04:34
|Link #1048
Join Date: Nov 2010
Location: somewhere on this planet
I'm annoyed at a female character not voiced by Rie Kugimiya!? That has to be a first. Chisato gotten too much emotional development that I can't see her not the end girl. Thats too bad. These VN Eroge adaptations never picks the girl I want to win. They too perfect for the MC. MC wants girl with flaws.
|2012-09-08, 04:42
|Link #1049
reading #hikaributts
Join Date: Feb 2009
|2012-09-08, 04:52
|Link #1050
I'm bound to disagree regarding the assumption on the Election and Love....
Chocolate probably refers to three the club, the past and Chisato...
Election is literally for the Election which determines if the club will continue to exist... It also points about the struggles of the club to win the election.
Love... again literally... Its not all about Satsuki, because if it is ..its bias in a sense and it directly questions the other girls' feelings....
The title is literal for me... Its all about the Chocolate, the election and the Love.....
Last edited by NoemiChan; 2012-09-08 at 05:02.
|2012-09-08, 04:54
|Link #1051
Divine Gundam Pilot
Join Date: Dec 2005
|2012-09-08, 04:56
|Link #1052
reading #hikaributts
Join Date: Feb 2009
Aside from me, atleast 3 others who have posted in thread have played the game.
|2012-09-08, 05:00
|Link #1053
Divine Gundam Pilot
Join Date: Dec 2005
|2012-09-08, 05:12
|Link #1054
You disgust me.
Join Date: Apr 2009
Location: UK
Age: 28
Huh, that's definitely a first for me. I went the entire episode actually focused on the story and without wishing that the show would end early.
I'm glad that they're finally putting focus on the financial aid students since that's where the biggest potential lies imo. But they're still irritatingly skimpy on the details. When Oojima decided to add it to his manifesto why didn't they talk about how that is affected by Satsuki's manifesto which they know includes financial aid students too? The way the story tries to swerve round issues like that so they can leave it for later feels way too forced. A good chance to finally clear things up too.
Chisato was indeed incredibly annoying this episode. I was pretty apathetic to her to begin with so it didn't take much to make me pissed off with her. But you what? I'm glad they've taken this direction. It finally adds something to her painfully flat character. I'm guessing the only reason we don't sympathise with her is because they're still refusing to explain to us why she's like that. Unfortunately that's a pretty bad way to go, since in the end we might be too pissed off with her to even hear the explanation by the end of it. So let's just hope to God that they clear the whole thing up next episode and get it over and done with. I still can't say I like the way they just throw in the drama when it comes to the characters. For me it hurt Satsuki's episodes too.
|2012-09-08, 06:34
|Link #1055
Senior Member
There's kind of two sides to politics. And I think we've allowed how Koi to Senkyo to Chocolate is excellent at portraying one side of it to maybe raise our expectations too much when it comes to how good Koi to Senkyo to Chocolate will be at portraying the other side of it.
The two sides of politics is actual political policy (which I take from your words to mean that you'd like to see more of), and what's sometimes called "the politics of politics".
Political policy is mainly about governing, and how you intend to run things once elected, and/or if you're already in government.
The politics of politics is about election campaigns, and the strategy and tactics that go into winning elections and maintaining an edge over your political opponents both in campaigns and outside of them (i.e. while just governing).
This anime has been very good at portraying the politics of politics. We see all the fundraising, all the campaigning, all the tactics, all the long-term political strategizing, all the media interactions - We see much of the best and some of the worst of what political campaigns tend to entail. Mind you, it's at a much smaller level than something like running for Head of State of a country, but it's still a pretty accurate depiction of what "the politics of politics" is like.
Heck, as much as Chisato annoyed me at times this episode, I did have to wryly grin over one very telling piece of advice she gave Oojima - "Don't run on this idea of yours, since it's not popular! Just do it anyway once you get elected!" That so reflects modern politics, and how cynical it frequently can be.
But even as good as this anime has been at portraying the politics of politics, it has indeed skimped out on its portrayal of political policy. But really, I think this is a case where we probably need to remember that this is first and foremost an eroge adaptation. While its overarching election plot is obviously important, it's also largely a vehicle for believably putting Oojima in various relationships with other girls aiding the romance side of things (it's actually rather ingenious, as this election plot manages to get Oojima around the old harem anime complaint of "How is this male lead managing to attract so many girls?!").
It's certainly possible that this anime will yet delve more substantively into political policy, but given how deep we are into this anime and how the romance side of things is far from resolved, I wouldn't get my expectations up too high there.
|2012-09-08, 06:44
|Link #1056
My posts are frivolous
Join Date: Nov 2008
Age: 30
^Agreed with the political side of the show. So far they've done quite a good job in portraying how politics is always about the interests of the individual/faction, and allies are never truly allies but parties with shared interests. For example, the Public Safety Commission is only helping Ooshima since they themselves can't run, and a greenhorn like him would be the easiest to oust in future. I wonder if we'll start to see gerrymandering and pork-barrel politics in the coming episodes.
On the relationship aspect, I like Michiru most but I'm not sure how they can actually resolve all the loose ends while having Oojima end up with anyone other than Satsuki, given the overall theme of the show. Satsuki is his election rival after all, and thus has the largest role among the girls in terms of plot.
|2012-09-08, 06:54
|Link #1057
You disgust me.
Join Date: Apr 2009
Location: UK
Age: 28
But still, even if it's not the main focus, it's not okay to force the issues away anyway. That scene where Oojima declares the financial aid students as part of his manifesto was obviously about his policies. And they also know that Satsuki's policies are about the aid students so naturally you'd think the conversation would follow in that direction. But it doesn't. They don't even consider it, even though it's the first thing I'd consider immediately. It's hard to feel for characters when they occasional act completely outside of any sort of logic, even if it's a supposedly minor thing like that. And it's not as if the way Oojima's new found manifesto being affected by Satsuki's manifesto isn't linked to the mechanics of the politics either so they don't really have any reason not to go there anyway.
|2012-09-08, 07:07
|Link #1058
Join Date: Dec 2003
Age: 37
So basically, you can't come to the conclusion that something is illogical just because it isn't shown (and because it's the first thing you'd consider if it were you). There are a lot of conversations that aren't shown (the outcome is assumed) or are severely abbreviated due to time-constraints. That may be unfortunate, but if your "being able to feel for characters" depends on seeing every logical conversation, I think that's asking for the impossible in such a short show. You have to be able to connect a few dots on your own.
|2012-09-08, 07:16
|Link #1059
I disagree with you all.
Join Date: Dec 2005
I don't really care about the pairings, but it infuriates me how willing to push the financial aid students under the bus Chisato is.
I think she may be wrong, too. It's possible the bullying is the fact of a very small part of the population, but the bulk is too cowardly or apathetic to do anything about it. They could view a vote for a defender of the financial aids as a way to feel good about themselves at no cost to themselves.
Last edited by Anh_Minh; 2012-09-08 at 08:19.
|2012-09-08, 08:07
|Link #1060
Senior Member
But Koi to Senkyo to Chocolate is balancing an awful lot - Not just its three premises (love, election, and chocolate), but also trying to squeeze in nice moments between Oojima and each of the main heroines. It is a real juggling act. While I admire the ambition behind it, I can't help but think that this anime might have been tighter if it made a clear romantic choice (Clannad-esque) and just ran with that instead of trying to get in something from each and every girl's route (that's my impression anyway, I haven't played the games).
The good news is that Oojima/Chisato will hopefully be resolved (one way or the other) next episode. If the resolution is an Oojima/Chisato romantic end... well, as much as that's not what I want, at least it would allow more focus to be put on the election for the last 2/3 episodes.
|bishoujo, drama, eroge, politics, romance, school life, seinen
|Thread Tools


text:
S4 E15 Episode 415
ENTREPRENEUR: Jennie Nigrosh
PITCH: The Green Garmento
ASKING FOR: $300k for a 20% stake
BEST PART OF THE PITCH: Jennie has created a garment bag that has multi-functions to create a cleaner closet and a cleaner planet. It can be turned in a space-saving hamper when turned inside-out. By bringing this bag into the dry cleaner, it eliminates the need for single-use plastic bags. Jennie says her company is approaching the million-dollar mark in sales. She also says her product saves money for the dry cleaners that buy and resell the bags.
DO THE SHARKS BITE? The sharks are skeptical when they learn that, even though Jennie has lots of sales, the company hasn't really made any money. In fact, she's actually been losing money. She also has investors who are taking 9% revenue until they get their money back. The numbers are not good. Robert and Barbara think it's a great product, but they'd be buying into a problem. They are both out. Kevin says that people fundamentally want to save the planet unless it costs them money like this product does. He's out. Mark says debt is not an entrepreneur's friend. He's out. Daymond applauds the effort Jennie has made, but he can't invest in the troubled business either.
LEARN MORE: Visit http://thegreengarmento.com/
In Season One, Tiffany Krumins made a deal with Barbara for her children's medicine dispenser called Ava the Elephant. Since her appearance in the tank, she's sold 100,000 units with over a million dollars in sales. She also created Ava the Elephant thermometer stickers that actually read children's temperature. Tiffany is now working with a logistics company and four international distributors. The success of the business has helped her financially and therapeutically.
ENTREPRENEUR: Matt Canepa & Pat Pezet
PITCH: Grinds
ASKING FOR: $75k for a 10% stake
BEST PART OF THE PITCH: Matt and Pat created coffee pouches that are filled with freshly-ground coffee that is then flavored and supplemented with vitamins and nutrients to keep you bright and alert. They call it a healthy alternative to chewing tobacco. They have used their background in sports to get their product into the hands of 20 pro teams. They are on track to do $300,000 in sales by the end of the year.
DO THE SHARKS BITE? Barbara loves the energy the guys show, but she can't relate to their product. She's out. Kevin believes the coffee companies may crush them. They need money to prevent that from happening. He offers them $100k for a royalty of 25 cents for every can sold. Robert offers $75k for 15%, but he'd like Daymond to come in on the deal because his specialty is distribution. Mark doesn't believe this product will give him a big enough return for his time. He's out.
THE RESULT: The guys want to know if Robert and Daymond would go up to $100k for the 15%, but the two sharks want more equity for that kind of deal. The guys then ask for more cash. That's not going to happen. The sharks are holding firm with their offer and that's ultimately good enough for Matt and Pat. Here's hoping these two former baseball players will hit a home run with their new partners.
ENTREPRENEUR: Scott Duff & Carlos Ortiz
PITCH: My Cold Snap
ASKING FOR: $50k and a 12% royalty for a 100% stake
BEST PART OF THE PITCH: Scott and Carlos have created a product that they claim is the only ice chest that fits in your hand. It holds a can that keeps a drink cold from the first sip to the last. They have $250k in sales in the promotional products industry in a deal that is now over. They have $20,000 units sitting in inventory. They've had a long period of activity when they put the product on hold.
DO THE SHARKS BITE? Barbara feels like the guys have taken a cold body out of storage and they want her to bring it back to life. She's out. Robert also has a problem with the fact that the business died years ago. He's out. Kevin doesn't think he can make any money from the product. He's out. Daymond believes that these guys are offering a hundred percent of their company because they want him to work for them. He's out. Mark doesn't like the product and he doesn't want to help it. He's out, too. My Cold Snap got a very cold reception from the sharks.
LEARN MORE: Visit http://www.mycoldsnap.com____________________
ENTREPRENEUR: Rebecca Rescate & Chris Hindley
PITCH: Hoodie Pillow
ASKING FOR: $90k for an 15% stake
BEST PART OF THE PITCH: Rebecca has been in the tank before. She sealed a deal with Kevin Harrington in Season 2 for her cat toilet-training system called CityKitty. She's broke a million bucks in sales with that product and is headed for $5 million. Her new venture is with a partner to pitch a product puts a hood onto a pillowcase. Daymond plops down on a couch to test the product. The other sharks think he looks ridiculous, but Rebecca argues he looks relaxed. They've sold 3,000 units in eight weeks. Chris invented the product and Rebecca owns 30% of the company. This makes her a mini-shark. They have a utility and design patent on the product. They also have a portable travel hoodie that you can use on planes. The sharks perk up when they see this product.
DO THE SHARKS BITE? Kevin offers $90k for a 33% stake but nobody can take a draw from the business until later. All three of them will take an equal draw when the time arrives. Chris offers Kevin 25% of the business for $100k, but Mr. Wonderful sticks with his original offer. Daymond also wants a third of the company for the $90k. He wants a decision in 10 seconds. Rebecca wants to hear from the other sharks, so Daymond is out. Barbara wants him to come back in on a deal with her for a 40% stake and a 10-cent royalty. Daymond is back in, but again wants an answer right away.
THE RESULT: Chris says he will do the deal with Daymond and Barbara if they'd accept 30% equity. This has the two sharks offering 35%, but Rebecca wants $90k for 20%. This has Barbara going out because they won't meet her halfway. Robert realizes he doesn't want to miss out on Rebecca again, so he's willing to give her what she asks. Chris can go for that. They have a deal!


text:
Staff writer
Hillsboro High School head boys' basketball coach Darrel Knoll said he does not like to compare a current team to past teams.
Each team develops an individual personality based on its players. Knoll is looking forward to finding the right rotations and the right plays to allow his 2012-13 squad to play cohesively.
That does not mean there aren't common denominators. Whether he was talking about his first state championship team in 1991 or the teams in the late '90s, Knoll said all of his best teams liked to play up-tempo with pressure defense and a fast-breaking offense, those teams could lock down on defense when they needed to, and collectively each unit had reservoir of physical and mental toughness to call upon in dire moments.
Knoll's current team already has two out of four of those factors. With a likely starting five of Brett Weinbrenner, Evan Ollenburger, Shaq Thiessen, Christian Ratzlaff, and Josh Wiebe, the Trojans will be as athletic as any team in 3A. Last year the Trojans were skilled in the open court, by applying full court pressure and running the floor in transition.
"When we were playing great ball last year, we were pushing the ball hard," Knoll said.
This season, the Trojans will look to use a tenacious man-to-man defense to make up for a lack of height. Each member of the Hillsboro top seven, including seniors Harry Faber and Tyler Proffitt, is a competent on-ball defender. Hillsboro was also adept at playing passing lanes for steals, to the tune of about 10 per game last season.
Leading the Trojans is junior point guard Brett Weinbrenner. At practice on Nov. 14, Weinbrenner was the first up in any drill, providing an example for his teammates. His handle is impeccable and his composure is equally airtight.
"Brett has a ton of ability to play basketball," Knoll said. "I put a lot of faith in his ability."
Floor general for Hillsboro is a difficult job filled with seemingly contradictory tasks. Knoll wants Weinbrenner to be aggressive and push the ball with every opportunity, but he also wants his junior guard to limit turnovers whenever possible. The Trojans turned the ball over about 10 times a game last year; Knoll wants that number to be the same, if not improve slightly.
Knoll wants Weinbrenner to be aggressive in the Hillsboro offense, looking to drive, draw multiple defenders, and then dish to the open teammates. He wants to see Weinbrenner's assists go up, but he also wants Weinbrenner to take advantage of scoring opportunities. He said most of Weinbrenner's shots last season were quality looks — mostly open 3-pointers and layups, with an occasional spot up jumper near the free throw line — and he wants that trend to continue.
On top of all of that, Weinbrenner often plays full-court defense, hassling an opposing team's point guard up the floor. The earlier he can force his opposite into an error, the better chance Hillsboro has of scoring on the other end. In any game, Weinbrenner needs to instinctively measure the flow of the contest and then adjust his game to what the Trojans need.
Right behind Weinbrenner in any drill Nov. 14 was Thiessen.
At times, Thiessen's considerable athletic gifts overshadow his skill. Knoll marveled how quickly Thiessen runs the floor, from standing to sprinting in about two steps. Thiessen is equally likely after to lead a Hillsboro break after picking off an errant pass or finish the possession with a highflying layup.
Thiessen was one of the team leaders in blocks last season and will be one of Hillsboro's better rebounders this season. As a 6-foot tall wing player, he uses his jumping ability to match the abilities of a taller player.
That said, Thiessen has worked to acquire the skills to be an offensive force. Like Weinbrenner, his handle is strong. He uses a variety of stutter steps, crossovers, and spins to get into the lane. Once he gets where he wants to go, he can finish in traffic, hit a mid-range jump shot, or drain it from 3-point range. He is Hillsboro's most difficult one-on-one cover and is destined to give opposing coaches nightmares.
Once either Weinbrenner or Thiessen get into the lane, Ratzlaff and Ollenburger will be waiting to spot up for open shots. Of the two juniors, Ratzlaff is the more natural gunner, looking to hoist a three at every opportunity and for good reason because he has a pretty stroke and the height to hit the shot over most defenders.
Ratzlaff also showed flashes of an all-around offensive game in the second half of the season last year. He was often the second wing for 3-on-2 breaks but he could finish at the basket in Hillsboro's half-court offense as well. He will be called upon this season to replace some of all-around contributions of Jesse Allen.
Knoll's concern for Ratzlaff is less about his play and more about his health. Ratzlaff struggled with a knee injury most of last season before sitting out for football this last fall. He also has a history of nagging back problems. As far as Knoll can tell in early practices, Ratzlaff seems to be operating at 100 percent and the Hillsboro coach would prefer to keep it that way.
Ollenburger earned starting time last season mainly for his effort on defense. In many games last year, he was asked to cover an opposing team's best scorer. He may be the toughest player on the team, showing a passion for diving for loose balls and completing other hustle plays.
Knoll said Ollenburger worked this summer to improve his shooting and vowed to include the junior guard as a bigger part of the offense.
That leaves senior post player Josh Wiebe to round out the starting five. Even though Wiebe was willing to run the floor and showed a talent for finishing at the rim with multiple defenders in the vicinity, Wiebe could go for stretches where he was forgotten in the Hillsboro offense.
It's not that Wiebe is not willing to partake in difficult physical tasks. Although he is 6-2, Wiebe is the Trojans only true post defender and he will be asked to push larger players off the block. Knoll said Wiebe has come into this season with added muscle to help him bang nightly in the post. He is also Hillsboro's best rebounder and he gave the Trojans several second chances on offense with his work on the glass last season.
Knoll wants Wiebe to get more touches, whether in the low post or from the high post positions, with his back to the basket or facing up. Knoll knows Wiebe will be a source of high-percentage shots.
The Trojans bench may be thin, at least to start the season. Faber and Proffitt both give the Trojans quality shooting and defense off the bench. Both players saw their playing time increase last season as they showed improvement. Fellow senior Jesse Brown offers an athletic option at guard off the bench.
Sophomore Micah Allen and newcomer junior Josh Davidson are vying for playing time, Allen as a long-armed guard and Davidson in the post.
Knoll said conditioning was going to be a point of emphasis any way, especially to develop mental toughness. Toughness is the last trait the Trojans have yet to develop. As the Trojans grind through these early practices, they'll show evidence of that toughness by pushing through fatigue.
Other moments to prove their toughness will have to wait for the first games of the season starting 7 p.m. Dec. 4 against Moundridge in Moundridge.


text:
Dihydropyrimidine dehydrogenase (DPD) Deficiency
Dear OncoLink "Ask The Experts,"
A family member was recently diagnosed with esophageal cancer. One of the chemotherapy treatments mentioned was Fluorouracil. We've read that if a person is DPD-deficient, the side effects could be severe, including death. Is there a test for this? Is this rare? Or should he avoid this drug completely? We've found articles on the internet that lead us to believe between 10% - 15% of the population have this deficiency.
Weijing Sun, MD, Assistant Professor of Medicine at the University of Pennsylvania, the Director of Upper GI and Pancreatic-biliary-hepatic Cancer Group and the Associate Director of the GI Cancer Program, responds:
Fluorouracil (5-FU) has been in use as a chemotherapy drug for more than 50 years. Overall, it is a safe drug, with relatively mild side effects in most patients.
DPD (aka Dihydropyrimidine dehydrogenase) is an enzyme that is necessary for the metabolism or breakdown of more than 80% of the 5-FU dose received. A lack of properly functioning DPD can lead to severe side effects, which tend to occur sooner than expected with functioning DPD.
'DPD deficiency' has been estimated by some to occur in 10% of all patients, but most studies have found 3-5% to be the actual incidence. The actual amount of functioning DPD varies widely in these patients, leading to variations in the amount and severity of side effects. Many of these can be prevented by adjusting the dose of 5-FU. Only 0.1-0.2% of the population has a complete lack of DPD, which would lead to the most severe toxicity. Although DPD levels can be tested, this testing is not typically performed or suggested at this point, but is an area of ongoing research. Researchers are looking at various tests that could be done to detect this abnormality, but feel that the currently available test is lacking in sensitivity and specificity.
Some researchers are looking at blocking DPD completely, making every patient completely deficient, allowing for better absorption of 5-FU, and making dose adjustments easier.
An interesting finding in some studies was that patients with lower levels of DPD had better responses to the chemotherapy when compared with patients with higher levels of DPD, who had poor responses to therapy. In another study looking at prescreening for abnormalities in the DPD gene, there were 300 patients in whom the authors could find no abnormalities. Despite this, 20 of these patients (6.6%) had severe side effects, suggesting that DPD is not the only culprit in 5-FU toxicity.
References & Further Reading
Gardiner, SJ et al., Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice Pharmacol Rev 2006 58(3): 521-590
Morel, A et al., Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil tolerance. Mol Cancer Ther 2006 5(11): 2895-2904
Van Kuilenberg, AB et al., Clinical Implications of Dihydropyrimidine Dehydrogenase (DPD) Deficiency in Patients with Severe 5-Fluorouracil-associated Toxicity: Identification of New Mutations in the DPD Gene Clinical Cancer Research 2000 Vol. 6, 4705-4712


text:
RALEIGH � A second House committee has agreed to give the city of Charlotte more flexibility with current hotel and prepared food taxes to pay for Carolina Panthers stadium improvements.
The House Finance Committee voted 21-11 Tuesday to expand how Charlotte can use part of those Mecklenburg County revenues beyond the Charlotte Convention Center to help with renovations to Bank of America Stadium.
The legislation does not provide what Charlotte city leaders want, a penny increase on the prepared food and beverage tax. Now others have scaled back their request to a half-cent increase.
Bill sponsor Rep. Ruth Samuelson of Charlotte says the bill would not give the city all it's asked for and would require leaders to prioritize spending among many projects. The measure now goes to the full House.


text:
Boy Scout Projects
|Charge Smoke Detectors
Use these ideas for your cub scout or boy scout group to perform a good turn. Whether you need a boy scout eagle project or a cub scout project, these ideas can be useful to find an interesting topic and adapt it to your needs. Older boys can take on more difficult tasks that require more strength, planning, and hours of work. Younger boys need to have a task that is short-term, obviously beneficial, but still requiring of an effort. Being able to see an impact from the work done is a great reward for scouts and a lasting eagle project that required significant planning, leadership, and sweat is a source of pride.
Jul 14, 2012 - Terry Leiter
I have a 3 year old grandson and I would like to do some projects that are on his level for enjoyment and as preparation for joining the ScoutsJul 14, 2012 - Scouter Paul
Terry - There is no preparation needed for a boy to join Scouts. If there's a Lion Cub program in your area, he can join that in kindergarten. Otherwise, he can become a Tiger Cub in first grade. The Scouting program is designed to offer age-appropriate activities and it requires absolutely no studying, preparation, or practice beforehand. Just play with him outside as much as possible and show him he can trust you and he's safe with you. Toddler and preschool activities are usually simple playing but you can find lots of ideas by searching online for "toddler projects".Sep 11, 2012 - Ladi C
we have a wolf c in our pack who rcievs blood tansfusion and he wants to do a blood drive. I saw that it was under "Boy Scouts" only... My question is: Can Cub Scouts sponsor blood drives to and if so what type of bage would they be eligeble for?Sep 11, 2012 - Scouter Paul
Ladi - Sure, a cub scout pack or den can organize or help with a blood drive. Cub scouts can't give blood but they can certainly assist with a drive. There are a lot of miscellaneous patchs you can purchase at scoutstuff.org and I bet you could find one that would work for a blood drive, but there is no cub scout requirement that doing a blood drive would fulfill.Feb 04, 2013 - Kristie
For one of our wood projects, we've decided to make bat houses, which has turned our wood project into a conservation project. The boys will be working with the community to place these bat houses in the right areas. But how do you top that? Any thoughts on cool wood projects that aren't too pricy?May 22, 2013 - Tamara
can a cub scout pack perform a U.S. flag disposal ceremony?May 22, 2013 - Mark Kirkendall
Tamara, Cub Scouts can; in fact, all US Citizens can. But first, please call it a Flag Retirement. Disposal has visions of trash being thrown out. There are many Flag Retirement Ceremonies listed on the web. The VFW has just adopted one standard retirement for their organization. Many Boy Scout Troops conduct Flag Retirement Ceremonies. Our Troop does one for Flag Day and our Rank Advancement Week. Cub Scouts are still alittle immature but, with proper leadership, they can be made to understand the importance and reverance of the ceremony. Mark Kirkendall Boy Scout Troop 632 and Retired Army Master Sergeant Tecumseh, MichiganNov 06, 2014 - David Risueño
To reach the rank of Life Scout, must the Scout develop his own Service Project or participate in any Scoutmaster approved project? Thank you for your helpNov 06, 2014 - Scouter Paul
@David - The requirement says "Take part in". The only leadership requirement in current rank advancement comes into play in the Eagle Scout requirements. For Life, the scout can help with some other scout's Eagle service project, or any other service that his scoutmaster approves. It's always a good idea to get that scoutmaster approval BEFORE doing the service, not as an afterthought. Some scoutmasters require the approval before the service, others do not.Aug 30, 2015 - Ken Zabel
Eagle Projects that are conservation projects can also be Hornaday Projects - and with a few conservation merit badges (and an expanded project report) - he can also earn the Hornaday Badge!
If 60% of his troop worked on the project they can also earn a Hornaday Unit Award.
CHECK THIS OUT: In 2014 there were 51,820 new Eagle Scouts - but only 115 Hornaday Badges and 32 Hornaday Unit Awards!
Check out this booklet and send me an e-mail if you would like me to be your Hornaday Advisor.
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If 60% of his troop worked on the project they can also earn a Hornaday Unit Award.
CHECK THIS OUT: In 2014 there were 51,820 new Eagle Scouts - but only 115 Hornaday Badges and 32 Hornaday Unit Awards!
Check out this booklet and send me an e-mail if you would like me to be your Hornaday Advisor.
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Wayne Kerr LS30-10 30A 10A DC Power Supply
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Mets back above .500 thanks to shutout of Cards
NEW YORK -- Through 19 games, the Mets continue to show their ragged edges at every turn. Their hitting is not where they want it to be. Their pitching has at times left much to be desired. They have hardly seized every opportunity in front of them, as manager Terry Collins readily admits.
But they are winning more often than not, and right now that's all that matters.View Full Game Coverage
NEW YORK -- Through 19 games, the Mets continue to show their ragged edges at every turn. Their hitting is not where they want it to be. Their pitching has at times left much to be desired. They have hardly seized every opportunity in front of them, as manager Terry Collins readily admits.
But they are winning more often than not, and right now that's all that matters.View Full Game Coverage
The Mets peeked back above .500 with a 2-0 win over the Cardinals on Monday, riding Jenrry Mejia's career-long scoreless innings streak, Travis d'Arnaud's improved hitting, some fine defense and Kyle Farnsworth's first save to victory at Citi Field.
From the start, Mejia was superb, striking out five over his first three innings. Showing no ill effects from the blister that forced him out of his previous outing after only 77 pitches, he buzzed his way through six innings without much issue.
"It bothered me a little bit, but last year I felt pain in here," Mejia said, pointing to the right elbow that required cleanup surgery over the offseason -- the insinuation being that if he could deal with that, he can deal with anything.
The Cardinals finally knocked Mejia out of the game by drawing back-to-back two-out walks in the seventh, but Scott Rice induced a ground ball to end that threat. After Carlos Torres pitched a scoreless eighth, Farnsworth entered and earned his first save as a Met.
Manager Terry Collins recently named Farnsworth the closer over Jose Valverde, who struggled in his attempt to replace injured ninth-inning man Bobby Parnell. After missing out on making the team in March due in part to poor velocity, Farnsworth has increased his fastball from the mid-80s to the mid-90s in a span of three weeks.
"I really don't look at that kind of stuff," Farnsworth said. "Arm strength comes over pitching in games and throwing. That's how arm strength comes along. So the looser you get, it's just one of those things. But I'm not concerned with velocity."
The Mets received all the offense they would need in the third inning, when David Wright's two-out single plated Eric Young Jr. (and also extended his hitting streak to 12 games). Insurance came in the form of d'Arnaud's RBI single in the sixth, though the Mets squandered a chance to do more with that rally after loading the bases with one out.
d'Arnaud finished with two hits, exorcising some of his early-season demons, but Curtis Granderson could not do the same, striking out three more times to sink deeper into what is now an 0-for-19 funk.
"I just need to get results," Granderson said. "I've just got to put the bat on the ball, put it in play, and hopefully, some good things will happen. That's the only thing really I can do."
For now the Mets are making up for Granderson's troubles with contributions from elsewhere. Collins singled out Rice and Torres for their performances on Monday, as they led a pitching staff that came through with its third shutout of the season and has not allowed a run in 17 innings. Shortstop Ruben Tejada came through with two fine defensive plays, including a highlight-reel double play to dampen the effects of a leadoff walk in the fifth.
But the star was Mejia, who increased his personal scoreless streak to 13 2/3 innings by pitching shutout ball into the seventh. Demonstrating better fastball command than he had in previous outings, he did not walk a batter until the fifth and struck out seven. He effectively shut down one of the best offenses in the National League, despite feeling the lingering effects of his blister.
Now entrenched in the rotation, Mejia should remain a significant part of it until his innings total begins climbing too high around midsummer. He is the embodiment of a team that did not know what to expect from him -- or themselves, in many ways -- just two weeks ago.
"He came to Spring Training bound and determined to be the fifth starter," Collins said. "There was a lot of talk this winter as to who it was going to be, and Jenrry put his mind to it. He got himself in great shape and … to pitch the way he did tonight, [it was] an outstanding job. We weren't sure what he was going to give us, and he gave us more than we expected, for sure."
Anthony DiComo is a reporter for MLB.com. Follow him on Twitter @AnthonyDicomo.


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The National Weather Service has issued a freezing rain advisory for western Montgomery and Chester counties from 10 p.m. tonight until 8 a.m. Saturday. The NWS says there could be mixed winter precipitation tonight in the form of snow and sleet which could change over to all freezing rain or drizzle. The precipitation could cause hazardous travel conditions as temperatures will remain in the lower 30s tonight.
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Hi there- Olfacta ! I LOVE reading your blog - been reading and lurking for a looong time. Great stuff. My fave is your article on Mitsouko - I re read often .
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St. Helen's Churchyard is still open for burials of people living in the Parish. We also have smaller plots available for ashes in our Tree of Life memorial garden. The church has burial records going back hundreds of years and indexes of these records are available in the Parish Office or through this website for people researching family history.
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Box Office: Captain America Sets an April Record
Apr 6, 2014 5:51 PM EDT
Captain America: The Winter Soldier dominated the box office this weekend, earning $96.2 million, surpassing Fast Five as the highest-grossing April debut, Box Office Mojo reports. Meanwhile, last weekend's No. 1 film, the Biblical epic Noah, plunged… Read more


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Languages: English, Vietnamese
Expertise: Anal Cancer, Bile Duct Cancer, Carcinoid Syndrome, Carcinoid Tumors, Cholangiocarcinoma, Colon Cancer, Colorectal Cancer, Gastric Cancer, Gastroesophageal Junction Cancer, Gastrointestinal Cancers, Gastrointestinal Tumors, Hepatocellular Cancer, Liver Cancer, Medical Oncology, Neuroendocrine Tumors, Pancreatic Cancer, Rectal Cancer, Small Bowel Cancer, Small Intestine Cancer, Stomach Cancer ...read more
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Dung Le, M.D. is an associate professor of oncology at the Johns Hopkins University School of Medicine and member of the Johns Hopkins Kimmel Cancer Center. Her research interests include novel approaches to patients with gastrointestinal malignancies. She has served as the principal investigator (PI) on many clinical trials focused on testing immunotherapy in patients with gastrointestinal malignancies and she has also served as the national PI on several studies including: anti-programmed death-1 (PD-1) in tumors with mismatch repair deficiency; a clinical trial in advanced pancreatic cancer patients evaluating the safety, tolerability and immune response to CRS-207, a listeria vaccine platform which has been modified to express the tumor antigen mesothelin; a multi-center, phase 2 study testing CRS-207 as a boost to allogenic pancreatic tumor cells transfected with GM-CSF gene (GVAX) for treatment of advanced pancreatic adenocarcinoma (PDA); a trial testing GVAX/ipilimumab in the maintenance setting for metastatic pancreatic cancer; and GVAX/CRS-207 +/- nivolumab in metastatic pancreatic cancer.
These studies incorporate extensive laboratory correlates and have involved collaborations with clinicians and bench scientists with expertise in the fields of immunotherapy and cancer genomics.
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Selected PublicationsView all on Pubmed
Le DT, Ladle BH, Lee T, Weiss V, Yao X, Leubner A, Armstrong TD, Jaffee EM. CD8(+) Foxp3(+) tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response. Internat J Cancer. Journal international du cancer. 2011;129(3):636-647. PMCID: PMC3064958. Role: Designed and performed the experiments. Conducted data analysis. Primary author on manuscript.
Le DT, Brockstedt DG, Nir-Paz R, Hampl J, Mathur S, Nemunaitis J, Sterman DH, Hassan R, Lutz E, Moyer B, Giedlin M, Louis JL, Sugar EA, Pons A, Cox AL, Levine J, Murphy AL, Illei P, Dubensky TW, Jr., Eiden JE, Jaffee EM, Laheru DA. A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction. Clin Cancer Res. 2012;18(3):858-868. PMCID: PMC3289408. Role: Lead investigator on multi-institutional study. Designed and conducted the study. Conducted analysis of both clinical and correlative studies and was primary author on manuscript. Funding: Received an ASCO Career Development Award to conduct this study.
Le DT, Lutz E, Uram JN, Sugar EA, Onners B, Solt S, Zheng L, Diaz LA Jr, Donehower RC, Jaffee EM, Laheru DA. Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J Immunotherapy. 2013;36(7):382-389. PMCID: PMC3779664. Role: Principal investigator study. Designed and conducted the study. Conducted analysis of both clinical and correlative studies and was primary author on manuscript. Funding: Wrote R21 that funded this study (R21CA126058-01A2).
Le DT, Wang-Gillam A, Picozzi V, Greten TF, Crocenzi T, Springett G, Morse M, Zeh H, Cohen D, Fine RL, Onners B, Uram JN, Laheru DA, Lutz ER, Solt S, Murphy AL, Skoble J, Lemmens E, Grous J, Dubensky T Jr, Brockstedt DG, Jaffee EM. Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes-Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer. J Clin Oncol. 2015 Jan 12. PMCID: PMC4397277; Role: Lead investigator on multi-institutional study. Designed and conducted the study. Conducted analysis of both clinical and correlative studies and was primary author on manuscript. Funding: Received a K23, Career Development Award to conduct this study. 1K23CA163672
Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, Biedrzycki B, Donehower RC, Zaheer A, Fisher GA, Crocenzi TS, Le JJ, Duffy SM, Goldberg RM, de la Chappelle A, Koshiji M, Bhaijee F, Huebner T, Hruban RH, Wood LD, Cuka N, Pardoll DM, Papadopoulos N, Kinzler KW, Zhou S, Cornish TC, Taube JM, Anders RA, Eshleman JR, Vogelstein B, Diaz LA Jr. PD-1 blockade in tumors with mismatch repair deficiency. NEJM. 2015. PMCID: PMC4481136; Role: Lead investigator on multi-institutional study. Designed and conducted study. Conducted analysis of both clinical and correlative studies and was primary author on manuscript. Funding: Received a GI SPORE grant to conduct microsatellite instability testing (MSI) for prescreening component of study (P50 CA62924).
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MILPITAS, Calif., June 23, 2016 – Western Digital® Corporation (NASDAQ: WDC), a global storage technology and solutions leader, today announced two new virtualization solutions designed to significantly improve virtual machine performance and density in VMware® vSphere® environments. These include the availability of the new FlashSoft® 4 software for VMware vSphere 6, and the introduction of the Flash Virtualization® System, a new flash-based hardware and software solution. FlashSoft 4 leverages a Western Digital and VMware VAIO co-design partnership for vSphere 6.
"The two-year collaboration between Western Digital and VMware has helped to advance storage solutions for VMware customers," said Ravi Swaminathan, vice president and general manager of the Data Center Solutions Business Unit at Western Digital Corporation. "These new product innovations resulted from the deep ongoing engagement between our companies and are expected to greatly enhance virtual machine performance. We look forward to expanding possibilities of the new architecture to continue delivering high-value solutions for our customers."
FlashSoft 4 software is based on an architecture that uses the new VMware vSphere APIs for IO Filtering (VAIO), providing the highest level of usability and performance1 with vSphere 6. FlashSoft 4 is the first host-based caching software to achieve VMware Ready™ certification for guaranteed compatibility, reliability and support. It also introduces support for VMware-supported datastores, virtual disk acceleration, improved performance and stability, and integrated management through the vSphere web client GUI.
The new Flash Virtualization System builds on the benefits of the latest FlashSoft software by pairing it with SanDisk ION Accelerator™ software and Fusion ioMemory™ PCIe solid-state accelerators in a flash-provisioned server capable of delivering over a million IOPS2 to accelerate storage I/O across the VMware environment. Without disrupting current server and storage infrastructure, the easy-to-deploy solution offers cluster-wide flash acceleration in existing VMware environments. The cost-effective solution also enables customers to get more performance and efficiency from existing storage and compute infrastructure, resulting in significant hardware and software savings.
"The VAIO framework represents the next generation of integration for third party data services integration in vSphere environments, enabling leading software solutions providers to align with VMware's vision for the software defined data center," said Yanbing Li, senior vice president and general manager, Storage and availability Business Unit, VMware. "Western Digital's support as a design partner for VAIO and the introduction of their new FlashSoft software illustrates the important role that our partners play in delivering on the promise of the software-defined data center."
"The FlashSoft 4 software for vSphere 6 using the VAIO API is in-line with Dell's vision for the software-defined data center. Using server-tier flash technology with FlashSoft host-based caching software is an innovative and cost effective way to increase application performance in virtual environments," said Ravi Pendekanti, vice president, Server Platform Development, Dell Inc. "We are excited to see VMware's support for host-based caching through the VAIO program, and VMware Ready certification will give customers the confidence to broadly adopt and deploy this innovative solution."
Pricing and Availability
FlashSoft 4 is immediately available as a solution bundle consisting of FlashSoft software and SanDisk® SAS, SATA, or Fusion ioMemory PCIe solid-state devices, with MSRP starting at $3600 to $5900 depending on the device. The software is offered through Western Digital, OEMs and reseller partners, including Dell, HPE, Lenovo and HDS, as well as select channel partners.
The Flash Virtualization System is also immediately available with MSRP starting at $75,000 (12.8TB3, 8-node cluster configuration).
About Western Digital
Western Digital Corporation (NASDAQ: WDC) is an industry-leading provider of storage technologies and solutions that enable people to create, leverage, experience and preserve data. The company addresses ever-changing market needs by providing a full portfolio of compelling, high-quality storage solutions with customer-focused innovation, high efficiency, flexibility and speed. Our products are marketed under the HGST, SanDisk and WD brands to OEMs, distributors, resellers, cloud infrastructure providers and consumers. For more information, please visit www.hgst.com, www.wdc.com, and www.sandisk.com.
About SanDisk
SanDisk®, a Western Digital Corporation (NASDAQ: WDC) brand, provides trusted and innovative flash storage products that have transformed the electronics industry. SanDisk's quality, state-of-the-art solutions are at the heart of many of the world's largest data centers, and embedded in advanced smartphones, tablets and PCs. SanDisk's consumer products are available at hundreds of thousands of retail stores worldwide.
© 2016 Western Digital Corporation or its affiliates. All rights reserved. Western Digital, [WD], SanDisk, FlashSoft, SanDisk ION Accelerator, Fusion ioMemory and Flash Virtualization are registered trademarks or trademarks of Western Digital Corporation or its affiliates in the U.S. and/or other countries. Other trademarks, registered trademarks, and/or service marks, indicated or otherwise, are the property of their respective owners.
1 https://blogs.vmware.com/virtualblocks/2015/02/05/vsphere-apis-for-io-filtering/
2 SanDisk ION Accelerator data sheet
3 1 TB = 1000 Gigabytes
Forward-Looking Statements
This news release contains certain forward-looking statements, including new product offerings and product availability that are based on current expectations and involve numerous risks and uncertainties that may cause these forward-looking statements to be inaccurate. Risks that may cause these forward-looking statements to be inaccurate include among others: need for higher capacity, faster storage solutions may not grow as expected, our product offerings may not be available when we expect or gain customer acceptance in the timeline we expect, and the other risks detailed from time-to-time in Western Digital's and SanDisk's Securities and Exchange Commission filings and reports. This news release contains information from third parties, which reflect their projections as of the date of issuance. All statements made in this news release are made only as of the date of this release. Western Digital undertakes no obligations to update the information in this release in the event facts or circumstances change after the date of this release.
Rebecca Parr
Western Digital
+1 408.801.3224


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Former Mizzou guard stays in the SEC
COLUMBIA - A former Mizzou guard is staying in the SEC and in the black and gold next year.
On Thursday, Akira Levy announced she will transfer home to Vanderbilt for the upcoming season. She is originally from Baxter, Tennessee, which is not far from Nashville.
The guard declared her entrance into the transfer portal on June 9th.
Levy averaged about four points per game but had her season cut short due to a knee injury.
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JEFFERSON CITY - The Cole County FEMA Disaster Relief Center in Jefferson City is wrapping up operations on Tuesday, but... More >>
JEFFERSON CITY - The Department of Health and Senior Services received over 2,100 medical marijuana facility applications by the deadline.... More >>