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This week's CSA includes:
1 Cucumber
3 Pieces Squash
1 Bag Fava Beans
1 Bag Potatoes
1 Bag Baby Speckled Romaine Lettuce
1 Bag Pea Shoots
1 Head Garlic
Meat Choices This Week:Whole Chicken, Half Chicken, Chicken Breast,
Chicken Leg/thighs, Pork Chops, Ground Pork, Bacon,
Country Ribs, Spare Ribs, Hot And Sweet Italian Sausage,
Pork Bratwurst, Spicy Pork Sausage Patties
Letterbox CSA Week 11, July 5, 2018
Gabriel's Sauteed Fava Beans
"When I was recently able to get ahold of fresh fava beans, I wanted to cook them in a way that highlighted the taste of the beans themselves, and here's how Gabriel Claycamp of Culinary Communion suggested I fix them."
Gabriel's Sauteed Fava Beans
This week's recipe comes from Julie R at Genius Kitchen
Boiling water
1 lb fresh fava beans, in the pod (yields about 1 1/2 to 2 cups shelled beans)
1/2 tablespoon butter
1/2 teaspoon olive oil
1 garlic clove, minced, to taste
Salt & freshly ground black pepper, to taste
In a large saucepan, bring water to a boil, then add salt – the amount depends on how much water you have, but it should be very salty, like seawater.
Shell the beans from the fava pods (I found it's sometimes easier - especially if you're new to fava beans - to open the pods when you run the edge of a knife along the seam, cutting away the tough edge so that the pod halves come apart).
In a bowl, combine ice and tap water to make ice water; set aside.
Add the shelled beans to the boiling water and let cook for about 3 minutes, then remove from saucepan and immediately plunge into the ice water to halt the cooking. Let the beans cool, then peel the outer skin from each of them.
Over medium heat in a skillet, melt together the butter and olive oil, then add the garlic and sauté for 1 minute. Add the peeled fava beans and sauté for about 5 to 7 minutes, or until they are done to your preference.
Season to taste with salt and freshly ground pepper, serve, and enjoy!
Note: in choosing your fava beans, get the pods that are firm and fresh looking; also, if you're feeling silly, have these along with your favorite liver dish and a nice Chianti.
Note 2: once you've made these basic fava beans, you can add other delicious items such as caramelized onions or fennel, chunky fresh tomatoes, and/or a bit of chopped proscuitto.
Note 3: I asked Gabriel if favas could be frozen effectively, and he said that yes, you can shuck them and blanch them for 1 minute at most, then freeze them in a single layer on a sheet in the freezer before putting them into bags; great bright green color and no mushiness in texture; thaw, peel, and use as usual.


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subset: commoncrawl


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56 Celebrity Tattoos That We Actually Like
56 Slides
Whether they're concealed on the red carpet, revealed with a clever caption on social media, or carefully shielded from the eyes of the public, countless celebs of all different ages have made their bodies home to some serious ink. And, whether influenced by a loved one, pulled from a favorite song, or something entirely out-of-the-box, you can pretty much count on A-listers for inspiring your next (or first-ever) tattoo. So without further ado, check out on some of the best ink inspo from your favorite celebs.


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Keeping Your Toddler Busy at Home
This past winter was a doozy. Up here in northern Michigan, it snowed straight through the first week of May. And while I personally didn't mind the quiet coziness of watching the snow fall on the trees in my backyard, my two small children were starting to go stir crazy, and I knew that watching Netflix and snacking on popcorn was only going to get us through so many days stuck inside our condo. Needless to say, whether it's below freezing outside or you just don't have the energy to head out with your kids every single day, it's good to have an arsenal of creative things to do with kids at home.
So, here's my giant list of fun year-round activities to do with kids without having to leave the house.
Toys, Games, and Other Supplies Every Kid Should Have to Stay Busy at Home
- A bucket of sidewalk chalk
- Sandbox or sand table and sturdy toys to explore with
- Kiddie pool or water table
- Dolls and a dollhouse to encourage imaginary play
- Age-appropriate puzzles
- Crayons!!
- Sidewalk toy (like a trike, scooter or another wheeled toy) and properly-fitting helmet
- Flashcards to encourage conversation
- Bubbles!
Mess Free Activities
Video Chat With a Friend
There's nothing my kids (and I) love doing more on a snowed-in evening than FaceTiming their cousin. To be extra-awesome, you could make video chat play dates with friends to give each other a spare 15 minutes to put the dishes away or blow dry your hair. Just set aside a half an hour and have each adult take turns overseeing that chat while the other gets a sweet break.
Download the PBS Kids App
Already consumed with cleaning up messes? Park your kid in front of the PBS Kids app where there are tons of free videos, games, and activities starring your favorite PBS characters (yeah, even that asshole, Caillou) that encourage development while giving you a break from the crayons and markers.
Invest in Mess-Free Art Toys
Do a little searching and you can come up with some wonderful, kinetic and colorful ways to let your kid explore without making a mess or spilling a bunch of tiny pieces. Products like Crayola's Mess-Free Touch Lights, Melissa and Doug's On the Go Water Wow! painting books, and Etch A Sketch Freestyle are all great options for getting creative without a mess.
Dance Party
Throw on some Spotify (we love The Crane Wives, Breathe Owl Breathe, or just some good old fashioned Taylor Swift pre-1989), grab some silk play scarves, and get the wiggles out.
Awesome and Educational Kids Shows That Are Streaming on Netflix and Amazon
Every family has their own standards/tolerance for television. But if you're up for letting your kids enjoy some good ole' fashioned TV, these titles are tops in my book (and my kids' too!):
On Amazon Prime Video:
- Tumble Leaf: Whimsical forest creatures explore the world in unique animation.
- If You Give a Mouse a Cookie: Mouse finds himself in silly, mixed up situations that he works out with the help of his friends in this adaptation of the children's picture book series.
- Guess How Much I Love You: From the beloved children's book, Big and Little Nutbrown Hare share adventures that will charm both you and your tot.
- Creative Galaxy: Similar in theme to Daniel Tiger's Neighborhood, Arty the alien learns important life lessons with guidance from his parents with the added bonus of live-action kids crafting art projects that your toddler can also create.
On Netflix:
- Puffin Rock: Narrated by the ever-charming Chris O'Dowd, Puffin babes Oona and Baba explore Ireland's coast in this sweet show about family.
- Llama Llama: Llama learns about school and friendship with the help of his busy and professional mama Llama, voiced by Jennifer Garner.
- Sarah & Duck: Two besties meet new friends and adventures in this quirky BBC program. Who cares that only one of them can speak human?
- Word Party: Diapered animal babies sing their way through manners and other basic tot-friendly social concepts.
- StoryBots Super Songs: Why is the sky blue? Why do cows moo? The StoryBots will answer these questions and more through hyped up songs that'll cheer up any kid on a rainy day.
Messy Activities
They'll need a bath after these.
Finger Paint the Bath
This one is super messy but if it's bath time anyway, squirt a few puddles of finger paint straight onto the bathtub, then let your little Picasso go nuts! It's best to do this activity in an empty tub, since sitting in paint water probably isn't great for their skin and you'll need to watch your little one well since paint + bathtub = slipping hazard. Still, this is a project my oldest daughter loved as a toddler and we did it often during the winter months. Once she was all done, I just turned on the water and rinsed her and the tub off so clean up isn't a total bummer on this one.
Make Pizzas Together
Whether you have a brand new toddler or an older kid, throwing fixings on a pizza is fun for all ages! I like to pre-chop everything and then section it out in an appetizer tray or in small bowls and let my girls go wild from there. You'll definitely need to vacuum and wipe down the counters afterward, but it's a fun and rewarding stay-at-home activity and you'll have dinner when you're all done!
More Messy Activities
- Trace with shaving cream in the bathtub
- Bath crayons (I like making messes in the same place I gotta clean the kids up, obviously)
- Cake decorating: I just buy a cheap ole box cake, bake it up and then let my girls frost and decorate with a couple cans of Funfetti.
- Soapy storage container: When you're just not in the mood to do a bubble bath, fill a plastic storage container with soap and warm water, set it on a big bath towel and throw in some toy boats to keep your toddler busy.
Quiet Activities
Play With Fairy Lights
Balloon Toss
Have an open package of birthday balloons in the junk drawer? Blow a few up and toss them around with your tot. Experiment with fans or the A/C to learn some simple physics.
Borrow Digital Material From the Library
Sign up for any digital programs your local library offers, like Hoopla. You can borrow kid-centric storybooks, documentaries. and music without ever leaving your house!
Turn the Windows into a Canvas With Washable Window Crayons
When my kids are done using these window crayons to create works of art on our backslider, I just spray it down with a few squirts of glass cleaner and a towel and everything's is back to new!
Dig for Treasures
Bury toy animals or any object that's safe for your kid (read: not a choking hazard) in the sandbox or sand table and have your little one dig for treasure.
In the Yard
Rock Painting
Collect a handful of rocks then break down a cardboard box and paint your new finds in the sunshine. You'll be able to contain the mess while getting some fresh air and doing a unique art project with your kids.
Collecting Leaves for Nature-Inspired Art Projects
Scour your backyard for leaves for leaf rubbings, bouquets or fairy houses. As you go along, use Google to identify trees and figure out which leaf came from which tree to really extend the outside opportunity of this perfect fall activity.
Picnic Breakfast
Too muggy to play outside today? Get up before the heat sets in and have breakfast on your patio. Spread out a blanket or set out a folding table and enjoy a great start to the day so you don't have to feel parent-guilt all day about not getting your kid outside enough.
More Fun Outdoor Activity Ideas
- Play yard games: Brands like Melissa and Doug and Hape have awesome outdoor games like croquet, hopscotch and bean toss games that can be easily stored away.
- Bubble machine: Buy a bubble machine from Amazon or your local delivery service and make homemade bubbles using dish soap (Method and Seventh Generation liquid dish soaps both make awesome and lovely smelling bubbles) and water to keep your kiddos busy catching, popping and chasing bubbles when the weather's nice.
- Draw people with chalk: Have your little one lay down on the sidewalk or patio and trace them. Then, hand over the chalk and have her color in her features, adding eyes, a nose, mouth clothing and whatever else she dreams up! This is also a great time to talk about colors and anatomy.
Questions & Answers
© 2018 Kierstin Gunsberg


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Redeem your hard-earned points now!
Please check out our store here: https://community.mimecast.com/store
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Through Missions (All of these are available to sort through -- earned and unearned -- in the Reputation tab of your profile!):
Through Actions (note that there are daily caps on lower-value activities such as "liking" content. Activities such as answering questions will ultimately earn you even more!):
|Individual Actions
|Have your reply be marked as correct
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|Someone voted on your Idea
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What is Mimecaster Central Gamification?
Mimecaster Central Gamification is a system that lets you earn points, badges, levels, and even prizes as you participate in the community. Your growing expertise gains you extra benefits, recognition and Mimecaster Central Swag!
This adds fun to our community participation by gamifying it. This includes rewarding points and badges to motivate you to create, interact with, or view different content types. You can start by participating in the community and earning points.
Here's more about the gamification terms used in Mimecaster Central:
Group of actions required to earn a badge and/or points. A single mission can reward you with points, a badge, or both.
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Completing Missions
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Check out what missions are available in Mimecaster Central by going to the top right and clicking your avatar > View Profile > Reputation. Then click on Missions in the left column.
You can use the drop down to sort the missions by Earned and Unearned:
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Earning Points
Participate in the community to earn points. These points are what you need to advance to higher levels.
Basically, you can earn points by taking certain actions in your community, such as liking a blog post, creating an idea, or asking a question.
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To see how you are ranking and available missions, visit your Profile.
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Enjoy your Mimecaster Central Swag: Wear it proud and wear it loud!


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My Birthday Wish for Lucky Number 27
There are 2 types of people in this world. The ones who plan strategically, make sure they have a soft landing, then jump off the cliff. Then there are those like myself that dive head first off the cliff leaving their fate up to the universe…
2014 and Lucky Number 27 has been the best year of my life thanks to a big leap of faith I took this April not knowing what events would transpire.
I quit my career, sold all of my possessions, and left the country to volunteer and live at a Christian Children's Refuge in Guatemala for 3 months. The best 3 months of my life so far.
I didn't even speak Spanish but I learned rapidly by interacting daily with the 33 children at the home. I learned more from this experience than I ever could in a classroom. These kids reminded me daily of what is most important in life which is God, Love, and Family. All the money in the world can't buy genuine love, a grateful attitude, or the time you take out of your life to spend with your friends, family, or loved ones. The kids hugged me everyday and within a couple of weeks opened their heart up and said Yo Te Quiero meaning I love you.
My note from Norma that she gave me before I left as well as her best handmade jewelry sprinkled with tears.
I consider each of them family now. A new spiritual family that opened my eyes and gave my life a new meaning. Now I know my purpose and it is to help these children continue to receive the blessings they deserve.
The children's home reached full capacity at 33 kids August of 2013 and have had to turn away numerous children in need because they don't have the space available to take more in.
I have 1674 friends on Facebook
If each friend would donate just $30 I would reach my goal of $50,000 to build "New Hope Orphanage and Rescue Center" which would save 100 more children from poverty, abuse, neglect and offer medical care, food, education, and an eternal family that can give them the unconditional love every child deserves.
You can help my wish come true by donating or sharing the link below to help spread awareness for this great cause on Facebook, LinkedIn, Twitter, Pinterest, and Google+


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Completed for Mr and Mrs R - Little Downham - April 2015
This was our Deepdale shaker style UK manufactured solid wood door in a stylish Dakar colour with German wood effect worktops. Complete Kitchens Ely designed, supplied and full installed the new kitchen, including plastering, new ceiling lights and electrical upgrades to bring the electrics to conform to current legislation. A stunning transformation!
Before & After


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The chinese secret to longevity in humans. Goji berries are full of antioxidants that cleanse the blood and dispose of any free radicals that maybe of harm to our cells. They are high in vitamins, A, B, C and E. Vitamin A being very good for anti-aging. Also they are good for the immunity, preventing cancer and heart disease and lowering cholesterol. Results show that eating goji berries may result in benefits such as mental well being, athletic performance, better sleep, calmness, happiness and health. You are able to find goji berries at your local grocery store, they are great on top of cereal or mixed in to a smoothie.
Tag Archives: superfood
Superfoods for a vibrant living
If you suffer from fatigue, anxiety, depression or can't get yourself to concentrate on anything then maybe you might want to incorporate some superfoods into your daily diet. Superfoods are foods that have super properties that are very beneficial to the body. For example, they may have high levels of antioxidants or they may have a high phytonutrient content (From the greek work "phyto" meaning plant and "nutrient"). Basically these foods are very nourishing and have a high concentration of essential nutrients beneficial to our health.
These are just some of the many superfoods out there:
-Wild Omega-3 rich fish, blue berries and pomegranates, olive oil, nuts, (walnuts,almonds,pine nuts, macadamia),Whole grains ( oats, whole wheat, barley), brown rice, red grapes, garlic and onion, green tea, broccoli, kale, cabbage, spinach, tomatoes, yogurt and dark chocolate


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Meet Olivia La Roche
On Her Morning Routine
I'm very bribe oriented. I guess you could call it "incentivized?" I get myself out of bed with the promise of tea and toast. I've tried a million other breakfast options, vegan bowl things, eggs, smoothies... but I'm a tea and toast gal. I love the "Wonder Bread" from Josey Baker at The Mill in San Francisco, and that's probably one of the things I miss the most. (and my family!) I'm looking for my NY replacement. The closest I've come is Roberta's (yeah the pizza place) sunflower sourdough. I tell myself it's healthy bread because it's so fermented... it's true! I recently quit coffee, so I drink green tea. I'm very into The Deep Steep right now, a toasty green tea from Steep Tea Co. I sometimes put avocados and anchovies on my toast, but mostly I go for plain toast with grass-fed cultured butter and a sprinkle of salt. I always take my breakfast back into bed to eat. It's a nice and slow part of the day (because I get up early) and my final farewell to bed.
on being a content creator
I'm a writer and artist. I write in my journal every day, and I am always jotting down ideas for stories and books - I have a few personal writing projects in the works and still occasionally sketch and paint. Creating content was a way to blend my love of fashion, photography, writing and art. I used to work on editorial/advertorial content for e-commerce primarily, but I've been branching out into visual content for social media, and I love it. Most of the time, I'm mixing it all on a project depending on the client's interests.
on being freelance and managing multiple clients
All my clients are interested in a unique vision, and we inspire each other. It's a two-way street. I rarely do anything overly commercial, and if I do, you probably won't see my name on it. It's important to me to work in collaboration. I'm really into time management and creating a meticulous workflow for myself. I dislike being stressed, but I like being productive, so I had to find systems to manage it all. Mostly I try and get up early; it's like giving yourself the gift of more hours in a day. Being in so many different roles keeps me stimulated. I thrive under pressure. I love the way each project blossoms into the next.
on founding a vintage store
I founded Petra von Kant (name inspired by Rainer Werner Fassbinder's film The Bitter Tears of Petra von Kant) with my business partner and friend Alexes Bowyer. We shared a vision, knew we had the skill set required, and we went for it. We both come from creative backgrounds (Alexes is a jewelry designer and expert metalsmith), and they fit perfectly with the multiple hats we wear. Together we buy, style, model, and take photos for the site.
on her style
I'm pretty "vintage" as my business would tell you. I'm always shopping for the brand, so I find things for myself all the time. I rarely have to go shopping for anything new. I would say aesthetically (and generally), I like odd things. I like to have things I've never seen before and probably won't again. I love textures and colors, and I think I approach dressing a bit more like an artist than a sartorialist. I'm into the composition of a look and see my wardrobe as a full palette. In my collection of non-vintage, I have a lot of Rachel Comey, Maryam Nassir Zadeh, and Issey Miyake.
on her health regimen
I think the biggest tips I can give are to check out Vitacost.com and earthshiftproducts.com. I love both for taking good care of myself. Earth Shift has these amazing skin and body detox kits, and Vitacost is basically the Whole Foods supplement aisle at like half off. I rotate what I am taking based on what my needs are, and everyone's needs are different. Now that it's winter I'm all about some raw vitamin D (Garden of Life D3 Vitamin Code Whole Food Raw D3 Vitamin Supplement). I also take a lot of hair, nail and skin vitamins, including my Super Powder Collagen which is all from Neo cell on Vitacost. I also recommend Vitacost DIM Complex with BroccoSinolate, NeoCell Laboratories Beauty Burst,
New Chapter Fish Oil Supplement and Vitanica, Iron Extra Vegetarian Capsules.
on her health tips
I add a pinch of Himalayan salt to my water and a scoop of powdered collagen for skin health. It's technically called "Sole" and helps your body hold on to hydration. The collagen is my addition. I also LOVE Moroccan red clay and always have it on hand for masks and first aid. It has the strongest drawing power of any clay and heals a pimple overnight. And, I basically put the refrigerator on my face too. I blend face masks from random ingredients that I know have benefits when I need a boost.
On her diy mask recipes
Here's a little key to masking from the fridge. Mix and match, it's literally all food so unless you're allergic you're not going to hurt yourself. For Moisturizing, mix yogurt, honey, olive oil, avocados, flax seeds, almonds, tofu, oats. For Exfoliating, mix papaya, strawberries, apple, ground rice, grapes, coffee. And for Purifying, mix aloe, brewers yeast, garlic, apple cider vinegar, turmeric (but it stains!), egg whites.
on her makeup routine
I am pretty boring with make-up/I look like a drag queen with ever-so-slightly too much. I wear RMS un-cover up everyday with a little Bare Minerals bronzer, Nars blush and some Fat and the Moon lip stain - I like Nars Lipsticks' "Clay Idol" or "Morocco" I top it all of with a swipe or two of Kevyn Aucoin The Volume Mascara - the kind that comes off in little tubes, no smudging!
On her favorite skincare products
Dr. Hauschka - I've been using these German biodynamic products since I was 15 and worked in a little herb shop. We sold it there, and the owner was in her 70's with the best skin I'd ever seen. She swore by Dr. H. I also think I like Sunday Riley, still trying a lot of their products and making up my mind. I'd say my top 4 right now are Rose Day Cream Light by Dr. Hauschka, Sunday Riley Blue Moon Tranquility Cleansing Balm, In Fiore Kashmir Body Balm and Tatcha Women's Soothing Rice Enzyme Powder. I also recommend Weleda Skin Food, Caudalie Beauty Exilir, Bioderma's Sensibio H20 Micellar Water, Avene Thermal Spring Water Spray, Weleda Sage Deodorant, Dr. Bronner's Magic Soaps 18-in-1 Hemp Pure-Castile Soap Lavender, Shiseido 'Extra Smooth' Sun Protection Lotion Broad Spectrum SPF 38 and Egyptian Magic All Purpose Skin Cream.
On her favorite haircare and body products
Davines' Dede Shampoo, Davines' Melu Conditioner, Kevin Murphy Balancing Wash Strengthening Daily Shampoo and Leonor Greyl Huile Secret de Beaute
on her wishlist
I need to restock all my RMS makeup. Issey Miyake Cauliflower T-shirts, Giorgio Armani Prive Bois d'Encens Eau De Parfum, and everything cozy from Lauren Manoogian. OH AND I need some Maison Margiela Tabi boots!
on her role model
My mom has run her own consulting business her entire adult life and traveled the world doing what she loves (which happens to be saving the planet). She is a professional environmental activist working on zero waste initiatives globally. When I was little and asked what our religion was, she said "recycling, " and I believed it. Aside from work, my mother is THE MOST shameless, self-confident human I have ever met. She and I talk about everything, but she's not one of those "friend moms" and the older I get, the more I realized her incredible power as a woman and how grateful I am to have been formed by that. She completely accepts who she is, and thus who I am. She's a continuous support system intellectually and always says "ask for what you want, appreciate what you get, and work on the difference."
Olivia's favorite books
Beauty by John Miller, Delta of Venus Erotica by Anais Nin, The Natural Way to Draw: A Working Plan for Art Study by Kimon Nicolaides and The Yoga-Sutra of Patanjali by Patanjali
Olivia's favorite movies
Eat Drink Man Woman, Working Girl, Prisoner of the Mountain, P.S. I love you, Wings of Desire, Once Bitten, Being There, Mr. Bean. Oh, and Grease, I know the words to every song.
Olivia's favorite spots in NYC
I love this odd little Turkish Health restaurant call Abracadabra.
I like Gottlieb's for matzo ball soup.
I do love the Bushwick co-op for local groceries.
Recently, I'm addicted to the spicy hot chocolate at this spot in Soho - L.A. Burdick.


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The Tower Of London (From A View Published About 1700.)1872-1878
This illustration is from Walter Thornbury "Old and new London, a narrative of its history, its people, and its places, vol. 2"
- This object is in collection:
- Edwin C. Bolles papers
- This illustration appears in:
- Old and New London, A Narrative of its History, its People and its Places. Illustrated with Numerous Engravings from the Most Authentic Sources. vol 2
- Subjects
- Engravings
- Building sites
- Boats
- Water
- London
- England
- Tower of London
- Permanent URL
- http://hdl.handle.net/10427/8706
|To Cite:
|DCA Citation Guide
|Detailed Rights
To request a high-resolution image, choose Add to List.


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Lucky Leprechaun Slots Game, Leprechaun Loot is a 5 reel, 20 payline slot machine game.
It works just like a real slot machine game. You can't win or lose any real money.
How to play Eagleslots: Leprechaun Loot:
To play, first add some virtual cash to your game – just click on the $50 or $100 notes to add $50 or $100. (If you haven't yet registered your game, you'll only be able to add 20 cents a time).
Once you've added your cash, click on one of the bet buttons on the top row – you can bet up to a huge $10 a time. The more you bet, the more you can win. You're now ready to play – so click the yellow SPIN button to start your way to fame and fortune. Click on autoplay if you prefer to sit back and watch the game play with itself. You can click on PAYTABLE at any time to see what the symbols will pay.
You can gamble any win to try and increase it – see here for how it works.
If you're heading out to the pub for a while, press RESERVE so everyone knows not to touch your game.
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The wait is over! A SPECTACULAR 3 BEDROOM + OFFICE, 2.75 BATH, 3 CAR GARAGE, SINGLE LEVEL HOME, WITH A CITY VIEW, ON ONE OF THE MOST DESIRABLE LOTS in Newport Ridge Estates is finally available! This home is one of the very few that features an open view beyond the reservoir to the city, and it only gets better at night when you combine the lit firepit, city lights, and Disneyland fireworks! This is the penultimate in light, bright, and open flowing floorplan. A complete renovation has infused classic sophistication, with a touch of modern and California cool. Upon entrance through the double doors your eye will be immediately drawn to the custom, roll away sliding glass doors that completely open, to bring the outdoors, inside. This is an ideal home for entertaining, or enjoy a private and luxurious night in. No detail was overlooked; from the beautiful new wood flooring throughout, stylish and contemporary remodeled bathrooms and kitchen, with all new lighting, freshly painted, two fireplaces, attractive and low maintenance backyard with firepit and view, and more...Not to mention, all of this is located in Newport Coast. One of the most sought after locations in all of Orange County. 3 Sea Terrace's close proximity to world class Crystal Cove beaches, 5-Star Premier Resort at Pelican Hill, Fashion Island, premium dining, shopping, entertainment, and breathtaking scenery offers a vacation feel 365 days a year, This wont last long...
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I think Stuart Wilde nailed it when he said "anger comes from loss." Anger and even frustration, in my opinion, are secondary emotions; the fiery layers above what's invariably underneath: a sense of loss. You're angry because you're losing something or you're afraid you will.
People choose anger over simply feeling the loss in the deepest sense because it's a more active emotion. Its ferocity keeps us feeling a sense of movement through the situation rather than feeling powerless over it. But anger can also trip you up and get you in trouble if you don't take the time to acknowledge, process and take action in response to what's really there.
Sitting down with your anger and agreeing to lose that thing your afraid of losing is a simple but liberating trick! So often we're holding on very tight in resistance to losing that thing, but resistance can keep us feeling very stuck! So what if you lost it? So maybe you don't prefer to lose it but what if you were simply willing to lose it?
For example say you've been dating a person who's super charming and charismatic but they've been giving you mixed signals and just cancelled the last date. Maybe you're angry with them for leading you on or being unclear. Maybe at this point you don't know for sure what they really want; perhaps they really are busy with work, or maybe they're a royal jerk dicking you around. Either way agree to lose it. It's not a pessimistic expectation that you are definitely going to lose it, it's just the willingness to.
Agree to the possibility that anything can happen from here. It's so simple but effective. It's just a choice. You might think "Oh so I don't actually NEED this person to be interested! Losing this romantic interest may not be what I prefer in this instance but I'm willing to let it go and leave it in time's trusted hands!"
Have you ever agreed to lose something in this way? I'd love to hear about what worked for you in the comments.


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Windows Error 3 Occured While Loading Java Vm
Conventions Refer to Cisco Technical Tips explicitly specifying the option "LAX_VM" together with the path to your JDK binaries. You can use a program Is your computer runningPlease try again later or
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Handmade Stoneware Pottery Mug With Copper Red Glaze, (Sku 30)
I made this piece on the pottery wheel using stoneware clay. It was fired in a natural gas kiln to 1800 degrees F, then dipped in a Copper Red glaze. Lastly, it was fired again to about 2300 degrees F. in a natural gas kiln. It is 100% functional, dishwasher safe and microwaveable. It measures about 4" tall by 5" wide.


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Travel agents can now book their clients on Emirates and Qantas codeshare flights, with bookings to Qantas domestic destinations now open.
After obtaining interim regulatory approval on their alliance earlier this month, the two airlines launched bookings on 32 Qantas flights across Australia, for travel from 31 March 2013.
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Also from 31 March, Emirates Skywards members will be able to earn Skywards Miles on Qantas international and domestic services that are part of a continuous international journey with Emirates or Qantas.
Meanwhile, the Australian regulatory body, the Australian Competition and Consumer Commission (ACCC) is still assessing the potential impact on codeshare flights between New Zealand and Australia.
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Ortho-Cyclen is an oral contraceptive that is made of two different female hormones. Ortho-Cyclenis primarily used to prevent pregnancy in women of child bearing age. Ortho-Cyclenmainly works by stopping ovulation and changing the uterine walls and thickening the cervical mucus. Therefore, the sperm cells cannot fertilize the egg, and a fertilized egg cannot develop in the uterus.
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Treatment of recurrent epithelial ovarian carcinoma with single-agent apatinib
Epithelial ovarian carcinoma (EOC) is the leading cause of death from gynecological cancers in women (1). An estimated up to 85% of patients with EOC will develop recurrent disease within 2 years even after radical surgery and combination chemotherapy (2). After recurrence, response rates to second-line chemotherapy for platinum-sensitive patients are approximately 30%, while for those, with platinum-resistant disease are only 10–25% to chemotherapeutic agents (3). The overall survival rate at 5 years is 50% and the 75% of patients die of recurrent disease (4,5). Thus, EOC is as regarded as a clinically incurable disease. Novel approaches with biologic agents that target the mechanisms of tumor growth and metastasis are needed.
Among the various factors contributing to tumor progression, angiogenesis plays an important role, as it helps tumor growth by ensuring sufficient oxygen and nutrient supply required for unlimited proliferation of tumor cells and growth of new blood vessels, and furthermore potentially results in tumor progression and metastasis (6). Basically, the direct interaction between tissue vascular endothelial growth factor receptors (VEGFRs) and their soluble ligands (VEGFs) mainly regulates the procedures of angiogenesis (7). The VEGFR family involves three kinds of type II transmembrane proteins (VEGFR-1, VEGFR-2 and VEGFR-3), which are characterized by a tyrosine kinase activity (8). Among these receptors, VEGFR-2 is the most important mediator of the VEGF-induced angiogenic signaling (8).
Apatinib (YN968D1) is a novel and strongly selective VEGFR-2 tyrosine kinase inhibitor (TKI) that targets the intracellular ATP binding site of the receptor, and prevents phosphorylation and subsequent downstream signaling (9). Here, we report a unique case of recurrent EOC, where the patient showed significant response to apatinib following the failure to chemotherapy.
Case presentation
A 59-year-old Chinese woman was admitted to our department with a 1-month history of irregular postmenopausal bleeding on January 7th 2015. The patient did not display any remarkable abnormality after physical examination, and had no history of hypertension, cardiac diseases, gastritis, gastric ulcer or nephritis. The ultrasound examination showed a 4.2 cm × 3.4 cm solid mass in the left adnexa uterus and a 5.7 cm × 4.0 cm one in the right adnexa uterus. A MRI scan revealed enlarged lymph nodes in the pelvic cavity. The serum levels of tumor markers were as follows: CA125, 2,871.00 U/mL, and ROMA index (postmenopausal), 98.61%. At the time of admission, the patient was diagnosed of postmenopausal bleeding, and the possibility of endometrium carcinoma, or ovarian carcinoma in both adnexa uteri.
Later on January 9th, a diagnostic curettage was performed and the pathological examination suggested breaks in the endometrium and proliferation stage in mucus. This result excluded endometrium carcinoma and indicated towards the likely possibility of the diagnosis of ovarian carcinoma.
Subsequently, after written informed consent was obtained from the patient, an operation incorporating of radical hysterectomy (removing the whole uterus, tissue on the sides of the uterus, the cervix, and 2–3 cm of the top part of the vagina), bilateral adnexectomy, omentectomy, appendectomy and metastasectomy of liver, diaphragm and peritoneum were performed on January 18th. Intra-operatively, a friable cauliflower-like 4.0 cm × 5.0 cm × 5.0 cm mass adhering to the left fallopian tube and ovary was observed, while the right ovary appeared normal in appearance. However, the right fallopian tube was about 2 cm thick, and displayed cauliflower-like tissue on its surface. Bilateral adnexa uteri were densely adhered to the pelvic wall and rectum, and cauliflower-like tissues were scattered on the pelvic peritoneal, but no ascites within the peritoneal cavity were observed. In addition, multiple metastatic masses of size of 2.0 cm × 2.0 cm on the surface of Glisson's capsule and diaphragm were observed. A metastatic mass in the size of 1.0 cm × 1.0 cm was also noticed in the ligamentum teres hepatic. The multiple metastatic masses of size 3.0 cm × 4.0 cm × 5.0 cm touching the surface of greater omentum were also observed. The resected masses from the pelvic cavity were sent for rapid pathological examination and led to confirmation of adenocarcinoma. The ovarian papillary serous carcinoma was confirmed based on the examination of intraoperative frozen sections (Figure 1). This poor differentiated carcinoma involved the serous surface of uterus and the right fallopian tube and surrounding fat. The metastatic masses in the pelvic cavity and surface of liver, diaphragm and sigmoid colon were confirmed to be papillary adenocarcinomas. Tumor cells were found in celiac metastases, ligamentum teres hepatic and greater omentum, but not in the ascites. Tumor thrombi were noticed in the vessels. These observations led to the diagnosis of papillary serous ovarian carcinoma of stage IIIC.
After this diagnosis, the patient received six cycles of chemotherapy involving the regimen of paclitaxel 210 mg on day 1 + nedaplatin 120 mg on day 2 on February 13th, March 3rd, March 28th, April 18th, May 10th and June 6th, respectively. The patient tolerated the chemotherapy well and the results of blood routine test, liver function and tumor markers were listed in Table 1.
Full table
Next, on August 5th, 2 months after the end of the first-line chemotherapy, the serum CA125 level of increased to 87.39 U/mL. In addition, a PET/CT scan on August 11th revealed enhanced uptake of 18F-labeled fluorodeoxyglucose (FDG) in the anterior median peritoneotome of upper abdomen, the left lobe and caudate lobe of the liver, splenic hilus and inside the spleen. This observation led to the diagnosis of recurrent ovarian carcinoma with extensive metastases into the abdominal cavity.
At this stage, multidisciplinary consultation involving specialists from oncology, interventional therapy and hepatobiliary surgery was scheduled. As the tumor had metastasized within 2 months after the six cycles of standard postoperative chemotherapy, oncologists suggested that the metastases were due to drug resistance and the summary of the advices from specialists included (I) interventional ablation; (II) resection of the spleen and metastases in the liver; (III) molecular targeted therapy; or (IV) chemotherapy with different regimens. Based on the general status of the patient the adopted treatment modality was decided to be second-line chemotherapy or molecular targeted therapy and followed by alternative surgery or interventional ablation.
In parallel, on August 27th, the levels of VEGF and RRM1 proteins were analyzed the results revealed high expression of VEGF protein and low expression of RRM1 protein, therefore suggesting that the patient was sensitive to apatinib. On the same day, the CA125 level elevated to 149 U/mL.
Meanwhile, the patient was willing and already scheduled to receive chemotherapy with the changed regimen including carboplatin 0.4 g day 1 plus gemcitabine 1,400 mg day 2. Thus, on August 28th, the carboplatin 0.4 g was administered, but the next day the patient developed fever with a peak of 38.2 °C and so the administration of gemcitabine was suspended. The blood routine tests on the following days displayed that levels of platelets, leukocytes and hemoglobin were progressively decreasing, with a minimum levels of 68×109/L, 101×109/L and 3.73 g/L, respectively. These results indicated serious bone marrow depression due to chemotherapy. Moreover, the serum level of CA125 on September 7th rose to 167 U/mL. Therefore, it was decided to terminate the administration of chemotherapy.
At this stage, after receiving the written consent from the patient, apatinib mesylate tablets (Chinese name Aitan) were administered at a dose of 250 mg twice a day after meals, starting on September 12th. On September 22th, the patient developed hypertension (range of 145–160/95–100 mmHg), along with anorexia, nausea and vomiting. In addition, on September 27th, dental ulcer and throat pain were also noticed, and by October 2nd the patient had complaints about abdominal pain and diarrhea. Then a gastroscopy revealed gastric ulcer. Besides, the patient was diagnosed of hand-foot syndrome on October 9th. But all these side effects or complaints were relieved or disappeared after symptomatic treatments.
Interestingly, the blood analysis of the results including BRT, liver functions and CA125 levels on October 10th, 27th and November 11th displayed normal. Specifically, the CA125 serum levels decreased to 10 U/mL and since then maintained normal. The ultrasound examination on November 11th did not identify any abnormality. The results of liver functions test on November 27th revealed ALT value of 111 U/L and AST value of 128 U/L, respectively. Thus, the administration of apatinib was discontinued. After hepatoprotective management until the liver function recovered to normal range, the administration of apatinib was continued at the same dose as previously. The December 27th CT scan revealed no abnormality in the former bilateral adnexa areas.
Finally on May 17th 2016, a PET/CT scan showed no enhanced FDG uptake in the abdomen or pelvic cavity (Figure 2). Moreover, the enhanced FDG uptake observed in the anterior median peritoneotome of upper abdomen, the left lobe and caudate lobe of the liver, splenic hilus and inside the spleen also disappeared when checked on August 11th, 2015. At this time, we accessed the state of disease and concluded that the patient had a partial remission. Since then regular CA125 tests and BRTs showed normal results, with the latest CA125 test on July 20th showing a value of 22.71 U/mL (Table 1).
This is the first report of a patient with recurrent EOC, responding positively to apatinib, a VEGFR-2 TKI. So far there has not been any similar report in the literature. This report highlights the experience of clinical physicians, while using apatinib in clinical practice.
EOC patients are usually expected to respond to initial chemotherapy, however, they often develop resistance to platinum-based regimens. The patient in our report also displayed similar characteristic. The antitumor effect mechanism of apatinib does not involve the inhibition of in vitro growth (cell proliferation) of cancer cell, but is mediated by its antiangiogenic role, which is different from the functional mechanism of chemotherapeutic agents (10).
Angiogenesis has been a crucial step for tumor cell survival, proliferation, local invasion, and distant metastasis (11). Overexpression of VEGF and VEGFR correlates with increased tumor cell growth rate, microvessel density, proliferation, metastatic potential and poor prognosis in multiple cancers (12). Therefore, inhibition of VEGFR signaling is a promising therapeutic target, and involves blockage of VEGF/VEGFR pathway through specific inhibitors (antibodies or small molecules), either binding to VEGF or interfering with certain domains of VEGFR. Recently, many VEGFR-2 inhibitors such as sorafenib, vandetanib, cediranib, and sunitinib have been developed (13-15).
Besides, apatinib can also effectively inhibit, to some extent, the activities of platelet-derived growth factor-b, c-kit and c-src proteins, all of which have been implicated in the pathogenesis of malignant tumors (16-18). Apatinib has also been shown to reverse the P-glycoprotein (ABCB1)- and ABCG2-mediated multidrug resistance in drug-resistant solid tumor cells by inhibiting their transport function (19). In addition, apatinib can also block the formation of rat aortic ring which mimics the multiple steps of in vitro angiogenesis (10). Based on these mechanisms, apatinib inhibits VEGF-stimulated endothelial cell migration and proliferation and subsequently not only decrease the tumor microvascular density (9), but also is able to circumvent cancer cell resistance to other antineoplastic agents. In the present case, apatinib exhibited its antitumor ability after the patient was resistant to the drugs in the first-line chemotherapy.
As a compound derived from valatinib, apatinib has shown superior efficacy in xenograft study (20). Also, its in vitro IC50 value for 50% enzymatic inhibition has been lower than other recently-developed anti-VEGFR agents such as sunitinib (0.001 vs. 0.005, respectively) (10,21).
The antitumor activity of apatinib has been validated in several preclinical tumor models (10), while its clinical efficacy has been demonstrated in patients with gastric cancer (22,23), hepatic cancer (24), breast cancer (24) and colorectal cancer (9). After its approval by China Food and Drug Administration, apatinib has been suggested to treat chemotherapy-refractory advanced gastric cancer and adenocarcinoma of the gastroesophageal junction for Chinese patients.
The pharmacokinetic and dose-escalation results indicate that apatinib is well tolerated by most patients at a daily dose of ≤850 mg (9). The results from a phase I clinical study showed that apatinib exhibits substantial antitumor activity across many malignancies at the recommended dose of 750 mg once daily (9). However, significant inter-patient variability with apatinib warrants dose modification to meet individual needs. Most side effects with dose of 500 mg/day were mild to moderate (25). For patients with non-small cell lung cancer, Zhang et al. (26) and Hu et al. (25) recommended an initial dose to be 500 mg rather than the originally reported 750 mg for treating other malignancies. In this report, the patient received a dose of 500 mg/day.
In generally, the toxicity of apatinib was controllable and tolerable and most of the side effects were caused by the inhibition of blood vessel endothelia. Systemic hypertension is a common side effect and can be attributed to the inhibition of VEGFR in arterial endothelial cells, and decrease in the release of nitric oxide, which then acts on arterial smooth muscle cells to cause vasodilation (27). Hypertension has been observed with all of the oral VEGF TKIs, as reported previously (28), and therefore, patients with preexisting hypertension should be evaluated cautiously for receiving apatinib, due to safety issues. If serious side effects, such as gastrointestinal perforation, urgent wound dehiscence, fistula, severe hemorrhage, nephritic syndrome or hypertensive crisis are observed, the apatinib administration should be immediately discontinued. So far, no study has reported a correlation between the appearance of side effects, as possible surrogate markers, and the response to apatinib.
It is important to have suitable biomarkers to predict the efficacy of antiangiogenic agents. A biomarker study of apatinib in patients with breast cancer showed that both hypertension and high expression of phosphorylated VEGFR-2 could serve as potential biomarkers for its efficacy (29).
CA125 is the tumor marker often considered as the "gold standard" in ovarian cancer (30) and can be measured with a simple blood test. The CA125 level has been shown to increase in majority of the EOC patients with EOC (9) and correlate with the course of the disease (10). Numerous studies have confirmed the usefulness of CA125 levels in monitoring the progress of patients with epithelial ovarian cancer (31-34). Commonly accepted definitions of disease recurrence based on serum CA125 levels alone specify a doubling of this tumor marker level, either from the upper limit of normal (35 U/mL) in patients with normalization of this marker after primary treatment or from the nadir levels in patients with an elevated serum marker value that never normalizes after primary treatment (35,36). Most reports indicate that a rise in CA125 levels precedes clinical detection by about 3 months (37). In our case, the CA125 level decreased to normal range under chemotherapy, indicating that our case was sensitive to CA125. And the elevation of CA125 value after the first-line chemotherapy was concurrent with the recurrence of disease. Besides, a PET/CT scan also revealed enhanced uptake of 18F-labeled FDG in multiple sites. Thus, the diagnosis of recurrent disease was made.
PET/CT has the better efficiency at detecting recurrent smaller tumors, thus allowing earlier detection particularly when the only evidence of recurrence is a steadily increasing serum CA125 level (38). Previous studies have demonstrated the ability of PET/CT to diagnose tumor recurrence even when the serum CA125 level is <30 U/mL or peritoneal implants are smaller than 2 cm. Generally, PET/CT has much better overall sensitivity, specificity, accuracy and positive- and negative-predictive values than CT or MRI in the detection of recurrent EOC. That is the reason why we selected PET/CT as an evaluation method.
In conclusion, recurrent EOC is probably incurable, and its management remains a challenge for clinical practitioners. However, in well-selected patients with recurrent EOC, apatinib may contribute to achieve clinical benefits with an acceptable safety profile. However, the definite efficacy of apatinib and the correct sequence of the treatment warrant further evaluation involving large-scale clinical trials.
Funding: This work was supported by grants from Society Development Plans, Department of Science and Technology Changzhou (CJ20159018).
Conflicts of Interest: The authors have no conflicts of interest to declare.
Informed Consent: Written informed consent was obtained from the patient for publication of this manuscript and any accompanying images.
- Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014. CA Cancer J Clin 2014;64:9-29. [Crossref] [PubMed]
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- Vargas-Hernández VM, Moreno-Eutimio MA, Acosta-Altamirano G, et al. Management of recurrent epithelial ovarian cancer. Gland Surg 2014;3:198-202. [PubMed]
- Wu MD, Wang Y, Ding T, et al. A retrospective clinical study of bevacizumab combined with gemcibabine or paclitaxel in the treatment of recurrent ovarian cancer. Indian J Cancer 2014;51 Suppl 3:e103-5. [Crossref] [PubMed]
- Rubin SC, Randall TC, Armstrong KA, et al. Ten-year follow-up of ovarian cancer patients after second-look laparotomy with negative findings. Obstet Gynecol 1999;93:21-4. [PubMed]
- Sullivan LA, Brekken RA. The VEGF family in cancer and antibody-based strategies for their inhibition. MAbs 2010;2:165-75. [Crossref] [PubMed]
- Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-76. [Crossref] [PubMed]
- Fontanella C, Ongaro E, Bolzonello S, et al. Clinical advances in the development of novel VEGFR2 inhibitors. Ann Transl Med 2014;2:123. [PubMed]
- Li J, Zhao X, Chen L, et al. Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in patients with advanced malignancies. BMC Cancer 2010;10:529. [Crossref] [PubMed]
- Tian S, Quan H, Xie C, et al. YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. Cancer Sci 2011;102:1374-80. [Crossref] [PubMed]
- Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000;407:249-57. [Crossref] [PubMed]
- Longo R, Gasparini G. Challenges for patient selection with VEGF inhibitors. Cancer Chemother Pharmacol 2007;60:151-70. [Crossref] [PubMed]
- Wood JM, Bold G, Buchdunger E, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 2000;60:2178-89. [PubMed]
- Clark JW, Eder JP, Ryan D, et al. Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors. Clin Cancer Res 2005;11:5472-80. [Crossref] [PubMed]
- Wedge SR, Ogilvie DJ, Dukes M, et al. ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy. Cancer Res 2000;60:970-5. [PubMed]
- Irby RB, Yeatman TJ. Role of Src expression and activation in human cancer. Oncogene 2000;19:5636-42. [Crossref] [PubMed]
- Heinrich MC, Blanke CD, Druker BJ, et al. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol 2002;20:1692-703. [Crossref] [PubMed]
- Song S, Ewald AJ, Stallcup W, et al. PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol 2005;7:870-9. [Crossref] [PubMed]
- Mi YJ, Liang YJ, Huang HB, et al. Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res 2010;70:7981-91. [Crossref] [PubMed]
- Chen P, Iruela-Arispe L, Lou L, et al. VEGFr inhibitor YN968D1 xenograft dose response studies against human colon cancer Ls174t and HT29. Proc Amer Assoc Cancer Res 2006;47:abstr 1764.
- Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003;9:327-37. [PubMed]
- Roviello G, Ravelli A, Polom K, et al. Apatinib: A novel receptor tyrosine kinase inhibitor for the treatment of gastric cancer. Cancer Lett 2016;372:187-91. [Crossref] [PubMed]
- Li J, Qin S, Xu J, et al. Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial. J Clin Oncol 2013;31:3219-25. [Crossref] [PubMed]
- Geng R, Li J. Apatinib for the treatment of gastric cancer. Expert Opin Pharmacother 2015;16:117-22. [Crossref] [PubMed]
- Hu X, Zhang J, Xu B, et al. Multicenter phase II study of apatinib, a novel VEGFR inhibitor in heavily pretreated patients with metastatic triple-negative breast cancer. Int J Cancer 2014;135:1961-9. [Crossref] [PubMed]
- Zhang L, Shi M, Huang C, et al. A phase II, multicenter, placebo-controlled trial of apatinib in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) after two previous treatment regimens. J Clin Oncol 2012;30 suppl; abstr 7548.
- Tang JR, Markham NE, Lin YJ, et al. Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor. Am J Physiol Lung Cell Mol Physiol 2004;287:L344-51. [Crossref] [PubMed]
- Izzedine H, Rixe O, Billemont B, et al. Angiogenesis inhibitor therapies: focus on kidney toxicity and hypertension. Am J Kidney Dis 2007;50:203-18. [Crossref] [PubMed]
- Fan M, Zhang J, Wang Z, et al. Phosphorylated VEGFR2 and hypertension: potential biomarkers to indicate VEGF-dependency of advanced breast cancer in anti-angiogenic therapy. Breast Cancer Res Treat 2014;143:141-51. [Crossref] [PubMed]
- Høgdall E. Cancer antigen 125 and prognosis. Curr Opin Obstet Gynecol 2008;20:4-8. [Crossref] [PubMed]
- Meyer T, Rustin GJ. Role of tumour markers in monitoring epithelial ovarian cancer. Br J Cancer 2000;82:1535-8. [PubMed]
- Bast RC Jr, Xu FJ, Yu YH, et al. CA 125: the past and the future. Int J Biol Markers 1998;13:179-87. [PubMed]
- Menon U, Jacobs IJ. Ovarian cancer screening in the general population. Curr Opin Obstet Gynecol 2001;13:61-4. [Crossref] [PubMed]
- Verheijen RH, von Mensdorff-Pouilly S, van Kamp GJ, et al. CA 125: fundamental and clinical aspects. Semin Cancer Biol 1999;9:117-24. [Crossref] [PubMed]
- Rustin GJ, Nelstrop AE, Tuxen MK, et al. Defining progression of ovarian carcinoma during follow-up according to CA 125: a North Thames Ovary Group Study. Ann Oncol 1996;7:361-4. [Crossref] [PubMed]
- Rustin GJ, Marples M, Nelstrop AE, et al. Use of CA-125 to define progression of ovarian cancer in patients with persistently elevated levels. J Clin Oncol 2001;19:4054-7. [PubMed]
- Yin BW, Lloyd KO. Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. J Biol Chem 2001;276:27371-5. [Crossref] [PubMed]
- Chu LC, Tsai HL, Wang H, et al. Posttreatment FDG PET/CT in predicting survival of patients with ovarian carcinoma. EJNMMI Res 2016;6:42. [Crossref] [PubMed]


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Sometimes it is nice to reflect and to think about what happened the past few weeks, months and year. In year 2013 I was convinced that, that year would bring me love. Guess what? It did but not in the way you are thinking…
The year 2013 learned me how to love and appreciate myself. It thought me how proud I should be of myself for passing my HAVO as a Dutch Surinamese girl who was brought up in Suriname. It gave me the strength and courage to study further. It thought me that by accepting myself just the way I am is the best way to live because I have to live with myself my whole life. And why should I waste my time by not feeling good about myself or not appreciating myself. It's a pity, a waste of time, and not worth thinking about.
In some way I had a lot of love for this year. I felt it in the air, way before the year started. I painted my predictions in this painting. I felt that the year 2013 was a year for new beginnings, love, inspirations, health, happiness, prosperity and different deeper feelings.
Why come with this is now and not earlier?
You should always reflect on how you feel or work. It is important because you'll get an insight on the things you did right and the things you can improve. By reflecting on yourself you can constantly change the way you view yourself, your situation or others. You can see what changed and what the difference is between last year and this year. By reflecting I see how last year changed me and when my new beginning started.
In this year I made yet another painting. I was so convinced that this year was a year for, all the above of course and, love. If you would manipulate the numbers of 2013 a bit you would get the word love.


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Here comes 2018
11 Monday Dec 2017
Posted Uncategorizedin
11 Monday Dec 2017
Posted Uncategorizedin
18 Monday Sep 2017
Posted CIPS, study, Uncategorizedin
I have been able to help many of you with CIPS past papers over the years but I now need your help.
There are many more past papers out there that you have access to that I may not have access to. I need help from a few volunteers to help me update the past papers folders (all levels) on Dropbox with additional past papers (2015 to date?) to make the folders as comprehensive as possible.
Sadly I had also given access to users unfamiliar with using Dropbox and at some point all content was deleted and then later restored-which is tricky because I don't know what was/ wasn't returned to the folders.
Please let me know if you would be able to help me get those updates done to help even more CIPS students on their CIPS journey. CIPS students need a lot of help out there, let's do this!
26 Tuesday Aug 2014
Posted Procurement, Uncategorizedin
How are you doing?
Remember this blog post I did about the free Ethics course available through CIPS? it was titled Free Elearn | Up your Ethics.
The offer for the course will be ending in October 2014!
As a CIPS member, achieving the CIPS Ethical Procurement and Supply certificate and being listed on the CIPS Community Register as ethically trained complements your membership and publically recognises your up to-date knowledge of, and ongoing commitment to, ethical procurement and supply. A testament to your commitment to ethics, it is highly recommended for all CIPS members
Check it out here
25 Monday Mar 2013
Posted Uncategorizedin
Many people send me emails asking me for past papers – once you register as a CIPS member (which you have to do anyway inorder for you to sit for CIPS exams) you will be given login details to the website and you get free access to all the past papers that you can dream of this includes the assessors comments on the questions and how they should have been answered – which really helps because questions over the years tend to be repeated sometimes.
Become a member of CIPS through you Britis council office or through emailing them to find out the easiest way – sometimes it is country specific firstname.lastname@example.com
08 Friday Mar 2013
Posted Uncategorizedin
It is the general elction period in Kenya this week. I think we are all a little bit glad that this is not happening during the holidays as last elections ended in dire post election violence that some Kenyan never recovered from. I think the economy is still moving on to be honest, aside from the negative publicity that international news seem to portray. To all fellow kenyans, stay safe and be good wherever you are lets keep this economy going.
In other news, i have finally started on my CIPS Level 5 exam preparation journey its going slow thats all i can report for now its going….
21 Wednesday Mar 2012
Posted Procurement, Procurement professional, Uncategorizedin
It is rare that procurement professionals really show any interest in the business aspect of their respective organisations. May be its a plain lack of interest or maybe they are too busy tied up doing their regular stock takes. Who cares what's going on the business world? You should, and here are a few reasons why:
Even when stuck back in the warehouse racks or your busy loading and dispatching trucks or placing orders, it is important to get your head out of the water and understand what business is affecting your business.


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By Kal Weinstein
Capital News Service
RICHMOND - Two groups have organized a march Saturday to call for the resignation of Gov. Ralph Northam over a racist photo in his medical school yearbook and for his comments concerning late-term abortions.
Buses will shuttle in people from all over Virginia for the "March on the Mansion," organized by the Douglass Leadership Institute and the Southern Christian Leadership Conference. The groups want to an "end to racism, and infanticide and a return to values of Dr. Martin Luther King and Frederick Douglass."
They have called on Virginians of all races, religions and political beliefs to join a "unity rally and march for righteousness and justice."
Saturday's March on the Mansion is unusual in that it combines the concerns over abortion and race into one protest.
A photo published worldwide from Northam's 1984 Eastern Virginia Medical School yearbook page showed a person in blackface and one in a Ku Klux Klan robe. Northam initially apologized for the photograph and then denied he was in the picture. He later admitted to putting shoe polish on his face for a Michael Jackson dance contest in 1984.
The picture was published days after the governor made national headlines for his support of a bill to relax restrictions on late-term abortions.
On a radio program, Northam, a pediatric neurologist, said third-trimester abortions are done when a fetus has severe deformities or is non-viable. In such cases, Northam said, "The infant would be delivered. The infant would be kept comfortable. The infant would be resuscitated if that's what the mother and the family desired, and then a discussion would ensue between the physicians and the mother."
That comment drew a backlash from abortion opponents. They accused Northam of advocating infanticide.
After the yearbook photo surfaced, there was a flurry of calls for Northam's resignation — from both Democratic and Republican leaders — but the governor resisted and promised "to lead Virginia forward."
Demonstrators will gather on the steps of the Virginia Capitol at 11:30 a.m. Saturday and then march to the governor's home at the Executive Mansion. Speakers at the march will include the Rev. Dean Nelson, chairman of the Douglass Leadership Institute, and the Rev. William Keen, president of the Virginia chapter of the Southern Christian Leadership Conference.
Andrew Shannon, the chapter's vice president, said the march will reiterate the values of Martin Luther King Jr., who founded the SCLC in 1957.
"We were easily able to bring these two leaders together based on their beliefs in the importance of life," Shannon said.
"We also think it's important for people to understand the long history of people using blackface as a stereotype to portray negative images of African Americans."
Shannon anticipates hundreds of people from throughout the state will attend the march, with buses available for passengers from the Suffolk, Portsmouth, Chesapeake, Hampton, Newport News, Danville, Pittsylvania County and Halifax.
Nelson said that if Northam emerges from his home to greet the protesters on Saturday, they would pray for him and ask him to step down.
Capital News Service is a program of Virginia Commonwealth University's Robertson School of Media and Culture. Students in the program provide state government coverage for a variety of media outlets in Virginia.


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What is the life span of the person with HIV ?
The patient after initial HIV infection, viral load was very high. The immune system then responded and lowers the number to a base level.
Now again the immune count is been reduced to 200, wherein doctor has suggested that the patient might require a separate treatment without connecting with the outside world.
what is the life expectancy of the person ? and how harmful is she to live among the common masses?
Hi there! Thanks for contacting the AIDS Vancouver helpline with your questions. We're happy to help!
Nowadays, we have extremely effective antiretroviral treatments for HIV. When diagnosed quickly and treatment is started as soon as possible, prognosis for HIV+ individuals is very good. Most people are able to bring down their viral load to very low or even undetectable levels when they adhere to their medication. Undetectable levels refers to less than 50 copies of viral RNA per mL of blood. HIV+ individuals who comply to their medication and stick to it consistently end up living normal lives with regular life spans! Sometimes, HIV+ individuals end up being even healthier than their HIV- counterparts, since they're more conscious of their health and take proactive measures such as eating healthy and exercising. Overall, the life span of HIV+ individuals can be the same as anyone else when they take their treatment properly.
Additionally, since treatment reduces the level of the virus in the body and the blood, it greatly decreases how infectious someone is. There is no need for an HIV+ person to ever be quarantined or separated from the world. If anything, the person should just disclose their status to any sexual partner, but other than that, they are free to live a normal life. When someone has a low or undetectable viral load, it's very unlikely that they will transmit the virus to anyone else.
I hope this helped!
AIDS Vancouver Online Helpline
Private & Confidential


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Craig Hella Johnson has been honored with numerous awards, including 2008 induction into the Austin Arts Hall of Fame, Chorus America's 2009 Louis Botto Award for Innovative Action and Entrepreneurial Zeal, and the 2011 Citation of Merit from professional music fraternity Mu Phi Epsilon, the organization's highest honor for a non-member. In 2012 he was an invited speaker for TEDxAustin. He was one of seven panelists for the Fetzer Institute and Eranos Foundation's "Love and the Musical Arts" gathering in Switzerland in 2011. In April 2013 Johnson was designated the official Texas State Musician for 2013 by the Texas Legislature. As a choral conductor, Johnson was awarded the 2015 Best Choral Performance Grammy® for Conspirare's CD The Sacred Spirit of Russia (Harmonia Mundi label). In June 2015 Johnson received The Michael Korn Founders Award for Development of the Professional Choral Art, Chorus America's lifetime achievement award.
A unique aspect of Johnson's programming is his signature "collage" style: through-composed programs that marry music and poetry to blend sacred and secular, classical and contemporary, traditional and popular styles. Craig's first concert-length composition, Considering Matthew Shepard, was premiered in 2016 by Conspirare. His works are published by Alliance Music Publications and he works with G. Schirmer Publishing on the Craig Hella Johnson Choral Series, featuring specially selected composers as well as some of his original compositions and arrangements.
A Minnesota native, Johnson studied at St. Olaf College, the Juilliard School, and the University of Illinois and earned his doctorate at Yale University. As the recipient of a National Arts Fellowship, Johnson studied with Helmuth Rilling at the International Bach Academy in Stuttgart, Germany.


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Garden Detective
Can tart grapefruit ever be sweet?
Experts tackle readers' garden questions.
Q: I have a grapefruit tree that was given to me, so I don't know the variety. The flesh is pink and the peel gets rosy. This year I had a bumper crop, however the fruit is less than desirable. The peel is very thick and the fruit is not sweet. I harvested in January. Was this too soon or too late? Is there anything I can do to improve my crop? I use a citrus food quarterly.
Linda Abel, Woodland
Bee garden writer Debbie Arrington:
Several different things are contributing to your grapefruit quandary. Pink grapefruit can be both tart and sweet. Their flavor can be influenced by weather, water and fertilizer.
Summer weather often is key to good grapefruit. Of all citrus, grapefruit have one of the highest heat requirements. They demand triple-digit July temperatures; that's when their sugars form. If summer weather is mild, those sugars never get started and the fruit will be very tart.
Grapefruit need a lot of hang time to ripen. Like all citrus, grapefruit has to ripen on the tree and will not get sweeter after harvest. It can take grapefruit 10 months or more to reach their peak.
In Sacramento, grapefruit actually is a late spring or summer crop – not winter. January grapefruit come from only the warmest areas, such as low desert regions in Arizona and California. According to the Cooperative Extension, grapefruit grown in interior California must be left on the tree until late spring or summer before it becomes edible, and even then flavor is often tart. Instead of January, pick in May or June. (So, yes, you did pick too soon.)
How do you know when to pick? Grapefruit turn color long before they're ready (although ripe pink grapefruit will have a red blush). Instead, pay attention to their shape and feel. Ripe citrus feels heavy but has a slight give when squeezed. As it ripens, grapefruit have a slightly oval shape with a little flatness on the top and bottom.
Bitter-tasting fruit often has its origins in irrigation – too much or too little, according to master gardeners Annie Kempies and Mary Griggs. Water deeply every 10 to 14 days, making sure the water penetrates the soil to a depth of 15 inches.
Use a soil probe or a trowel to make sure the roots are receiving the right amount of water. Do not water (or dig) right at the trunk, as the feeder roots are farther way, near the drip line.
To help retain soil moisture and minimize weeds, add a layer of mulch 2 to 4 inches deep around the tree, making sure you leave about a 12-inch space between the trunk and the beginning of the mulch.
Thick rind usually indicates too much nitrogen fertilizer. Grapefruit need a little nitrogen boost in late winter and early spring when they flower and set fruit. But UC Cooperative Extension specialists point out that high levels of nitrogen fertilizer are to be avoided for oranges and grapefruit during the summer and fall, as that contributes to thicker rind, lower juice content, and regreening of Valencia oranges.
So, feed your tree a little citrus food now, but skip the summer and fall feedings. Many home citrus growers report success (and sweet fruit) with no added fertilizer at all.
Older grapefruit varieties tend to be tarter. According to UC experts, grapefruit have a history of very sour flavor and only recently have been hybridized to produce sweeter fruit. Some varieties never taste sweet; that may be part of your tree's issues. Juice from that tart fruit can be blended with other sweeter citrus (such as oranges) and still be used.
For additional information, Four Winds Growers has an extensive website with information on citrus varieties and care: www.fourwindsgrowers.com.
The Bee's Debbie Arrington is a consulting rosarian and lifelong gardener; firstname.lastname@example.com, 916-321-1075, @debarrington
Garden questions?
Questions are answered by master gardeners at the UC Cooperative Extension services in Sacramento and Placer counties. Send questions to Garden Detective, P.O. Box 15779, Sacramento, CA 95852. Send email to firstname.lastname@example.com. Please put "Garden Detective" in the subject field and include your postal address. To contact UC Extension directly, call:
- Sacramento: 916-875-6913; 9 a.m.-noon and 1-4 p.m. Monday-Thursday
- Amador: 209-223-6838; 10 a.m.-noon Monday-Thursday; website: ceamador.ucdavis.edu
- Butte: 530-538-7201; 8 a.m.-noon and 1-5 p.m. weekdays
- Colusa: 530-458-0570; 9 a.m.-noon and 1-4 p.m. Tuesdays; website: cecolusa.ucanr.edu
- El Dorado: 530-621-5512; 9 a.m.-noon Tuesday-Friday
- Placer: 530-889-7388; 9 a.m.-noon Tuesday-Thursday or leave a message and calls will be returned; website: pcmg.ucanr.org/got_questions
- Nevada: 530-273-0919; 9 a.m.-noon Tuesday-Thursday or leave a message
- Shasta, Tehama, Trinity: 530-242-2219; email email@example.com
- Solano: 707-784-1322; leave a message and calls will be returned
- Sutter, Yuba: 530-822-7515; 9 a.m.-noon Monday-Tuesday and 1-4 p.m. Thursdays
- Yolo: 530-666-8737; 9-11 a.m. Tuesdays and Fridays, or leave a message and calls will be returned


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Official Tie of Ice Hockey Australia featuring a woven shadow of the logo in ultra fine polyester satin.
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Get ready to make your friends jealous when you wear this beautiful ladies Geneva Quartz link watch featuring a faux tiger design with rhinestones surrounding the face, and a gorgeous alloy silver colored chain bracelet. Worn together, they make a real fashion statement.
Bracelet Details and Fit: Mixed Metals. 6" with 1" extension.
Watch Details: Mixed Metals. 7".


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Haroshi "GUZO" exhibition at the NANZUKA gallery
Haroshi, the artist behind all the intricate trophies given away to the winner of the Battle at The Berrics skateboard competition, and also known through his collaborations with HUF, is having a solo exhibition at the NANZUKA gallery in Tokyo. Haroshi have been making sculpture works and installations using scraped board decks since 2003. To make the sculptures he stacks the decks collected in layers like a block and cuts out the models from there. For this exhibit, he made a total of 20 figures as well as another art installation that will be on display until June 10, 2017. Check out a few photos above and make sure to stop by if you have the chance.


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It is the Olympics again after a four years wait. Records will be broken and new superstars will be born from a single moment of brilliance. However, there are two women sprint records from the late eighties which may prove to be too big a challenge for our sprinters today.
These records are held by the one and only Florence Griffith-Joyner.
Popularly known as Flo-Jo, Florence Griffith-Joyner was the most flamboyant athlete of all time. There hasn't been anyone as colourful before her and there hasn't been anyone in her league ever since in the last 20 years. She has pioneered sporting fashion sense in the eighties with her psychedelic outfits and topped her flamboyance with her Nail Art.
In the last five years, Nail Art where catchy designs and colours finally became popular but Flo-Jo did it twenty years ago when the norm then was only mono tone nail varnish. Sports and vanity did not mixed. Most athletes wouldn't even use neutral coloured varnish but prefer to opt for the natural look. But not Flo-Jo. She not only did her nails to match her attire. And she did it all in style.
The important thing was that Flo-Jo proved to the world that she wasn't just some attention seeker without the capability to match her flamboyance. Flo-Jo blazed the running lanes and she left all her competition behind.
In 1987, Flo-Jo broke the World Record for the 100 meters clocking at 10.49 seconds during the US Olympics trials. Many felt that the run was wind assisted but the official wind meter showed no wind and her record was recognised.
Then in the 1988 Olympics, Flo-Jo won the 100 meters at 10.54 seconds proving to her critics that she was indeed the fastest woman in the world.
In the same Olympics, Flo-Jo went one up by breaking the 200 meters World Record by running a 21.34 second sprint.
Today, 20 years later Flo-Jo's records for both the 100 meters and 200 meters stayed intact.
Will these records be broken during the Beijing Olympics? They all tried during the last four Olympics but failed. It is unlikely to be any different in Beijing. We will know by 17th August 2008.
Her decision quit at the pinnacle of her career after the 1988 Olympics fueled her critics' suspicions that she was avoiding the mandatory random drugs testing which was implemented in 1989.
Unfortunately, Flo-Jo died prematurely in her sleep on 21 September 1998 where the official cause of death was suffocation as a result of a severe epileptic seizure. Her untimely death cast further suspicions of drug abuse or even the effects of steroids or some performance enhancing drugs.
Despite the controversy surrounding her, she will remain as the only women sprinter who has held the official World Records for both the 100 meters and 200 meters sprint for 20 years. Whether or not, her World records will be broken this Olympics, Flo-Jo will always the one and only Flo-Jo. She was and will continue to be the most flamboyant superstar race queen ever.


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If you have any special orders or you are concerned about specific delivery days… please email, call us, or you can note it in the order box provided. If you call us and we are unavailable, please leave a message and we will return your call that day. We are located in the West Cost, Pacific Time. Packages are sent through USPS priority mail except for the 11.7 oz. – 10 packs and the 3 oz. – 30 packs those will be shipped through UPS or FedEx.


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One of Britain's brightest hopes for podium glory at this year's summer Olympics, 22-year-old table tennis wizard Darius took the time out from his intense training schedule to show FHM around the highlights of his extensive animation collection...
The Original Adventures of Superman
Properly old-school, black-and-white Superman cartoons from the 1940s.
"Superman is my favourite superhero, he does what I do; fly from country to country trying to beat guys! I love anything to do with Superman.
Insanely popular anime series about an adolescent ninja.
"Naruto is an inspiration when I'm training or competing. He's the most talented guy but he works really hard."
Street Fighter Alpha: The Movie
A 1999 anime taken on evergreen fighting series.
"When I was a kid I played Street Fighter II on the SNES all the time."
Sonic The Hedgehog
Spiky, leaping lunacy.
"I grew up with Sonic and watching the cartoons, Sonic evolves with each series. Sonic X is the best.
disney's ducked-up take on Scrooge.
"Scrooge has got all his nephews and I've got a little brother, and nephew and a godson so, yeah, I'm Scrooge, man!
Hand drawn mega-hit from Disney's early 90s golden period.
"I like that he's a street-rat. I've come from the bottom, too – anyone can find their magic carpet and fly.
Batman: The Animated Series
Widely regarded as one of the greatest ever takes on the Dark Knight.
"I used to watch this every week on Live & Kicking."
Death Note
Anime series, later adapted into two live-action movies.
"It's a Japanese anime about a guy who can kill you by writing your name in a book. It's witty stuff."
Spirited Away
This Japanese anime won an Oscar for best animated feature of 2002.
"Brilliant, but every time I watch it I fall asleep!"
Peter Pan
Disney's 1953 classic, and Michael Jackson's favourite movie.
"Peter's the boy that never grew up, a bit like me. I love traditional Disney films – I'm not into the Pixar stuff. Besides, tell a lady you've got Disney and you're on to a winner."


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James Goehmann brought more than four decades of teaching experience, including nearly three decades as math department chair, when he joined the Upper School faculty at Morgan Park Academy this fall.
Mr. Goehmann teaches AP Calculus AB, honors pre-calculus, and honors geometry; leads an advisory group; sits on the Upper School's Honor Council; and is a faculty moderator for our Illinois Council of Teachers of Mathematics (ICTM) competition team.
He studied at the University of Chicago, where he earned a B.A. in mathematics and a Master of Arts in Teaching degree.
What do you enjoy most about teaching?
I enjoy it when students succeed in mathematics beyond the level they thought they could achieve. I enjoy the sense of accomplishment that students get when they overcome difficult math topics, especially if they were anxious about their ability to handle those topics.