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Stratified Medicine - BSc (Hons) - Video
The right treatment, for the right person, at the right time.Take a look
Graduates from this course are employed in many different roles
- Bioinformatician
- Clincial trial design
- Computational biologist
- Medical researcher
In this section
The right treatment, for the right person, at the right time.
Study Stratified Medicine at Ulster University in the United Kingdom.
Stratified medicine, also known as personalised medicine, is at the cutting edge of a new era in healthcare.
Our ability to understand how genes, lifestyle and environment can influence disease promises to revolutionise healthcare practices. Stratified medicine relies on the use of biomarkers (such as genes or proteins) to stratify (or organise) patients into groups of individuals who are at risk of developing a disease, or who are likely to respond better to one therapy over other alternatives.
It also focuses on the development of new technologies and systems to predict disease, select the best treatment, and reduce side effects for individual patients. This approach to streamlining healthcare provides more accurate clinical decision making tools to identify 'the right treatment, for the right person, at the right time.'
To learn more about stratified medicine in practice and how Ulster University is using it to treat rheumatoid arthritis patients, you can read our blog post here.
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Magee campus
Our vision is aligned to the strategic growth plan for the city and regionWatch the video
About this course
In this section
The Stratified Medicine BSc Hons is a three-year, full-time course (or four years with optional placement). In year one students will study six modules which will establish a strong foundation in topics such as physiology, disease and treatment, pharmacogenomics, clinical governance, computer programming and the 'omics' (genomics, proteomics and metabolomics).
Year two will consist of six modules which will develop your expertise 'in silico', with applied computer programming, data management and analysis and 'in vivo' with study of specific disease epidemiology and pathologies.
An optional placement year is available in year three, which provides a wide range of opportunities for students to experience professional work experience in an industrial, hospital or university environment.
Final year provides essential know-how of clinical trial design and analysis, healthcare economics and the application of your acquired expertise through completion of a research project (data analysis/clinical/basic science research).
You will gain an in-depth understanding of disease systems, molecular pharmacology, genetic and proteomic biomarker discovery and validation, and bioinformatic and statistical analyses of large patient and 'omic' datasets.
You will exit this progamme with a highly sought-after combination of expertise in biomedicine, bioinformatics and biostatistics and will be well-equipped to become part of a rapidly expanding workforce on the cutting edge of medical progress. You will be well positioned for a career in research, the health service, and the pharmaceutical and diagnostics industries.
The programme incorporates professional skills developed in collaboration with a dedicated Industrial Liaison Committee, comprising over 30 industrial partners located throughout the UK, Ireland and the US, which includes companies like Randox Laboratories, Almac Diagnostics, GlaxoSmithKline and Aridhia.
Your future career will no doubt improve patients' quality of life through better healthcare, and smarter technologies to treat and manage diseases such as heart disease, diabetes, neurological disorders, cancer or immune disease.
Associate awards
Diploma in Professional Practice DPP
Diploma in Professional Practice International DPPI
Find out more about placement awards
Full time.
Start dates
- September 2019
Teaching, Learning and Assessment
The content for each course is summarised on the relevant course page, along with an overview of the modules that make up the course.
Each course is approved by the University and meets the expectations of:
- the relevant generic national Qualification Descriptor
- the applicable Subject Benchmark Statement
- the requirements of any professional, regulatory, statutory and accrediting bodies.
Attendance and Independent Study
As part of your course induction, you will be provided with details of the organisation and management of the course, including attendance and assessment requirements - usually in the form of a timetable. For full-time courses, the precise timetable for each semester is not confirmed until close to the start date and may be subject to some change in the early weeks as all courses settle into their planned patterns. For part-time courses which require attendance on particular days and times, an expectation of the days and periods of attendance will be included in the letter of offer. A course handbook is also made available.
Courses comprise modules for which the notional effort involved is indicated by its credit rating. Each credit point represents 10 hours of student effort. Undergraduate courses typically contain 10- or 20-credit modules (more usually 20) and postgraduate course typically 15- or 30-credit modules.
The normal study load expectation for an undergraduate full-time course of study in the standard academic year is 120 credit points. This amounts to around 36-42 hours of expected teaching and learning per week, inclusive of attendance requirements for lectures, seminars, tutorials, practical work, fieldwork or other scheduled classes, private study, and assessment. Part-time study load is the same as full-time pro-rata, with each credit point representing 10 hours of student effort.
Postgraduate Master's courses typically comprise 180 credits, taken in three semesters when studied full-time. A Postgraduate Certificate (PGCert) comprises 60 credits and can usually be completed on a part-time basis in one year. A 120-credit Postgraduate Diploma (PGDip) can usually be completed on a part-time basis in two years.
Class contact times vary by course and type of module. Typically, for a module predominantly delivered through lectures you can expect at least 3 contact hours per week (lectures/seminars/tutorials). Laboratory classes often require a greater intensity of attendance in blocks. Some modules may combine lecture and laboratory. The precise model will depend on the course you apply for and may be subject to change from year to year for quality or enhancement reasons. Prospective students will be consulted about any significant changes.
Assessment methods vary and are defined explicitly in each module. Assessment can be a combination of examination and coursework but may also be only one of these methods. Assessment is designed to assess your achievement of the module's stated learning outcomes. You can expect to receive timely feedback on all coursework assessment. The precise assessment will depend on the module and may be subject to change from year to year for quality or enhancement reasons. You will be consulted about any significant changes.
Coursework can take many forms, for example: essay, report, seminar paper, test, presentation, dissertation, design, artefacts, portfolio, journal, group work. The precise form and combination of assessment will depend on the course you apply for and the module. Details will be made available in advance through induction, the course handbook, the module specification and the assessment timetable. The details are subject to change from year to year for quality or enhancement reasons. You will be consulted about any significant changes.
Normally, a module will have 4 learning outcomes, and no more than 2 items of assessment. An item of assessment can comprise more than one task. The notional workload and the equivalence across types of assessment is standardised.
Calculation of the Final Award
The class of Honours awarded in Bachelor's degrees is usually determined by calculation of an aggregate mark based on performance across the modules at Levels 5 and 6, (which correspond to the second and third year of full-time attendance).
Level 6 modules contribute 70% of the aggregate mark and Level 5 contributes 30% to the calculation of the class of the award. Classification of integrated Master's degrees with Honours include a Level 7 component. The calculation in this case is: 50% Level 7, 30% Level 6, 20% Level 5. At least half the Level 5 modules must be studied at the University for Level 5 to be included in the calculation of the class.
All other qualifications have an overall grade determined by results in modules from the final level of study. In Master's degrees of more than 200 credit points the final 120 points usually determine the overall grading.
Academic profile
The University employs over 1,000 suitably qualified and experienced academic staff - 59% have PhDs in their subject field and many have professional body recognition.
Courses are taught by staff who are Professors (25%), Readers, Senior Lecturers (18%) or Lecturers (57%).
We require most academic staff to be qualified to teach in higher education: 82% hold either Postgraduate Certificates in Higher Education Practice or higher. Most academic staff (81%) are accredited fellows of the Higher Education Academy (HEA) - the university sector professional body for teaching and learning. Many academic and technical staff hold other professional body designations related to their subject or scholarly practice.
The profiles of many academic staff can be found on the University's departmental websites and give a detailed insight into the range of staffing and expertise. The precise staffing for a course will depend on the department(s) involved and the availability and management of staff. This is subject to change annually and is confirmed in the timetable issued at the start of the course.
Occasionally, teaching may be supplemented by suitably qualified part-time staff (usually qualified researchers) and specialist guest lecturers. In these cases, all staff are inducted, mostly through our staff development programme 'First Steps to Teaching'. In some cases, usually for provision in one of our out-centres, Recognised University Teachers are involved, supported by the University in suitable professional development for teaching.
Figures correct for academic year 2019-2020.
Here is a guide to the subjects studied on this course.
Courses are continually reviewed to take advantage of new teaching approaches and developments in research, industry and the professions. Please be aware that modules may change for your year of entry. The exact modules available and their order may vary depending on course updates, staff availability, timetabling and student demand. Please contact the course team for the most up to date module list.
In this section
Year one
Biochemistry and Cell Biology
Year: 1
Status: C
This module aims to provide an introduction to the structure, biochemistry, metabolism and function of key biological macromolecules including nucleic acids, carbohydrates, proteins and lipids. Students will construct knowledge of the building blocks of key biochemicals which are essential to cell function and human health. students will explore the relationship between macromolecule structure and function in the context of cell biology, human health and disease. Through practical classes which are designed to complement central concepts, students will have the opportunity to reinforce and develop their theoretical knowledge base.
Anatomy and Systems Based Physiology
Year: 1
Status: C
This module will introduce fundamental aspects of anatomy and physiology under conditions of health. Students will learn how a range of anatomical systems function in the normal state, which will prepare them for the study of disease pathophysiology in later semesters.
Mathematical Methods
Year: 1
Status: C
This module establishes the fundamental concepts of data handling and analysis . Students will learn the fundamental mathematics required to process and analyse data and the fundamental programming concepts required to implement analysis. This modules will establish a critical level of literacy in applied mathematics and computing that is applicable across all quantitative sciences.
Genetic Inheritance and Genetic Variation in Human Disease
Year: 1
Status: C
This module will introduce the basic principles of genetic inheritance, from Mendelian laws to examples of autosomal, sex-linked and maternal human inheritance patterns, and provide a solid grounding in mathematical calculations for assessing the probability of inheriting different types of genetic traits. The topic of epigenetics and trans-generational epigenetic inheritance will also be introduced, alongside a consideration of genetic variation and its relationship to disease susceptibility. The genetics of whole populations will be considered, how allele and genotypic frequencies are calculated, and how they change within a population due to evolutionary pressures. The module will also cover methods for the analysis of large and small-scale DNA changes, as will statistical methods for population-based genetic association mapping. Underlining this will be real world examples of how genetic analysis methods can be applied for biomarker discovery in relation to drug response and disease risk.
Clinical governance, regulatory processes & ethics
Year: 1
Status: C
This module seeks to provide students with an introduction to the concepts of clinical governance, its regulatory processes and how it relates to ethics. The module also covers research governance and good ethical research practice. It creates a foundation for the clinical trials design and patient recruitment level 6 module. Teaching includes lectures and tutorials.
Disease and treatment
Year: 1
Status: C
This module will introduce fundamental aspects of disease systems and treatment approaches in stratified medicine covering topics ranging from the classification of disease to current and emerging trends in therapeutics.
Year two
Epidemiology of Disease
Year: 2
Status: C
The purpose of this module is to describe the concepts behind the epidemiology, how it influences human health policy and discuss the types of study, analyses and interpretation in tracking human disease and how this relates to stratification of patients into clinically relevant subgroups.
Pharmacology and Pharmcogenomics
Year: 2
Status: C
This module will introduce the basic principles of how drugs work in the body and how individual variation (including genetics) can hamper this process. This is particularly relevant to the concept of non-response - something that is targeted with stratified medicine. Worked examples of specific disease states will help students understand the complexity of the pharmacological treatment pathways and how stratification may aid these processes.
Statistical and Computing Methods
Year: 2
Status: C
This module develops fundamental knowledge and understanding of statistical and computing methods, training students with the practical skills to implement and/or apply these methods using a statistical computing language to tackle typical data analytic tasks in biomedical sciences and stratified medicine.
Neurological Disease
Year: 2
Status: C
This module provides insight into the cellular and molecular causes of common neurological diseases, their treatment and the potential to stratify patients for most appropriate therapies
Inflammatory and immunological Diseases
Year: 2
Status: C
The purpose of this module is to describe key immune/inflammatory disease causes, effects on sufferers, clinical management strategies, molecular pathways of disease and the potential application of stratified medicine.
Psychiatry for Stratified Medicine
Year: 2
Status: C
This module provides an overview of aetiology, diagnosis, pathophysiology and treatment of psychiatric disorders and integrates this knowledge with an understanding of the role of a stratified approach to clinical and psychiatric management strategies.
Year three
Placement: Diploma in Professional Practice (International) (DPP/DPPI)
Status: O
Year: 3
This module is optional
This placement experience is designed to provide an insight into the world of work, to consolidate knowledge and skills acquired during the first two years and to promote the development of transferable skills.
Year four
Multi-omics and Systems Biology
Year: 4
Status: C
This module develops key concepts in systems biology and omics data analysis, providing hands-on experience of cutting-edge analytical tools and approaches, with a strong emphasis on making sense of omics data and systems models in their biomedical context. Students will learn the importance of interpreting analytical output in its biological and biomedical context - translating raw data into biological meaning. Graduates will possess a robust conceptual framework that facilitates understanding of analytical approaches across the many different types of omics data, and skills and confidence in their ability to analyze, interpret, and effectively communicate systems biology models and omics data analysis.
Translational Stratified Medicine Portfolio (Entrepreneurship)
Year: 4
Status: C
This module will introduce entrepreneurship concepts focussed on launching a business in the biotechnology or health sectors. It will provide an overview of the steps necessary in planning, forming and funding a new 'biobusiness' and managing intellectual property and commercialisation of novel products.
Clinical decision making and health economics
Year: 4
Status: C
This module explores the development of new personalised medicine products, from idea inception to performance evaluation and clinical uptake. It explores personalised medicine from the regulatory and clinician's point of view, examining existing and emerging technologies and systems. It provides an appreciation of the regulation and clinical guidance which is required to ensure the use of tests are evidence-based and considers the impact of their application to patient management including the economic cost-benefit analysis.
Clinical Research Project
Year: 4
Status: C
This module provides students with experience of an independent original scientific research study. It provides experience of planning, organisation, conduct, critical analysis and reporting/presentation of research study findings. Students will complete an individual research project on a topic relevant to current research in Personalised Medicine. Graduates will have experienced independent, supervised, original research, and been provided with an opportunity to plan a research project, identify/resolve ethical issues, collect and analyse data, present and defend their findings, and write a scientific paper.
Biomedical Informatics
Year: 4
Status: C
This module will provide an understanding of biomedical informatics and its use within basic research and applied research and practice. It will build on knowledge gained in the level 4 module genetic inheritance, genomics, proteomics and metabolomics.
Clinical trials design and patient recruitment
Status: O
Year: 4
This module is optional
This module provides an integrated study of clinical trial design, patient recruitment and the regulatory and ethical processes involved. It builds on the concepts developed in the level 4 module clinical governance, regulatory processes and ethics module. This knowledge is integrated with an understanding of the role of clinical trials in progressing research and development of disease therapies.
Clinical or Fundamental research design
Status: O
Year: 4
This module is optional
This module seeks to guide students to use their skills and knowledge acquired to date to (1) challenge the scientific literature, and (2) to generate hypothesis and develop clinical or fundamental research plan, in a disease area of their choice, that may inform future stratification of patients. Through the module students will use their presentation skills, capacity to work together, as well as their capacity to develop and structure ideas.
Stratified Medicine & Healthcare Innovation
Status: O
Year: 4
This module is optional
This module will review the fundamental principles of healthcare economics in the field of stratified medicine and explores current approaches highlighting the shortfalls in the existing paradigm which must be addressed. Practical skills for evaluating the clinical and economic benefits of stratification are also developed.
Entry conditions
We recognise a range of qualifications for admission to our courses. In addition to the specific entry conditions for this course you must also meet the University's General Entrance Requirements.
In this section
- A level
- Applied General Qualifications
- Irish Leaving Certificate
- Scottish Highers
- Scottish Advanced Highers
- International Baccalaureate
- Access to Higher Education (HE)
- English Language Requirements
- Additional Entry Requirements
A level
The A Level requirement for this course is BBB to include 2 science subjects – 1 from Group A and 1 from Group B
Group A: Information Technology, Digital Technology, Physics, Mathematics
Group B: Biology, Chemistry, Double Award Science
Provided the subject requirements are met you can substitute a combination of alternative qualifications recognised by the University for one A level Grade B.
Applied General Qualifications
Overall BTEC award profile DDM (to include 9 distinctions) in an appropriate acceptable science discipline.
Irish Leaving Certificate
Irish Leaving Cert (Higher Level) grades H3,H3,H3,H3,H3 to include 2 science subjects – 1 from Group A and 1 from Group B:
Group A: Information Technology, Physics, Mathematics
Group B: Biology, Chemistry
Plus English and Maths Grade H6 or above (HL) or Grade O4 or above (OL) if not sitting at Higher Level.
Scottish Highers
The Scottish Highers requirement for this course is BBBCC to include Grade B in 2 science subjects – 1 from Group A and 1 from Group B
Group A: Information Technology, Digital Technology, Physics, Mathematics
Group B: Biology, Chemistry, Double Award Science.
Scottish Advanced Highers
The Scottish Advanced Highers requirement for this course is CCC to include 2 science subjects – 1 from Group A and 1 from Group B
Group A: Information Technology, Digital Technology, Physics, Mathematics
Group B: Biology, Chemistry, Double Award Science.
International Baccalaureate
Overall International Baccalaureate profile minimum 26 points (to include minimum 13 at higher level) to include 2 science subjects – 1 from Group A and 1 from Group B
Group A: Information Technology, Physics, Mathematics
Group B: Biology, Chemistry, Double Award Science.
Access to Higher Education (HE)
Access Course (120 credits) with an overall mark of 70%, to include 70% in two Level 3 modules - 1 from Group A and 1 from Group B:
Group A: Information Technology, Physics, Mathematics
Group B: Biology, Chemistry
Plus NICATs Maths (25 credits) or Maths 1 & 2.
GCSE Profile to include Grade C or 4 or above in English, Mathematics and Biology or Double Award Science at grade C,C/4,4.
English Language Requirements
English language requirements for international applicants
The minimum requirement for this course is Academic IELTS 6.0 with no band score less than 5.5. Trinity ISE: Pass at level III also meets this requirement for Tier 4 visa purposes.
Ulster recognises a number of other English language tests and comparable IELTS equivalent scores.
Additional Entry Requirements
Satisfactory health screening will be required.
Acceptable alternative qualifications include:
HND entry requirement:
Pass HND in an acceptable science discipline with overall Merit to include 60 distinctions in level 5 credits/units
HNC entry requirement:
Pass HNC in an acceptable science discipline with overall Distinction to include 90 distinctions in level 4/5 credits/units
You may also meet the course entry requirements with combinations of the different qualifications to the same standard as recognised by the University (provided subject requirements as noted above are met). Examples of acceptable combinations include:
2 A Levels and BTEC Subsidiary Diploma
OCR National Diploma and BTEC Subsidiary Diploma
2 A Levels and Cambridge Technical Introductory Diploma
A Level and BTEC National Diploma
For further information regarding combination offer requirements, please contact Faculty Office staff T: +44 (0)28 71267 5027 or E: email@example.com
Careers & opportunities
In this section
Job roles
Graduates from this course are employed in many different roles. Here are some examples:
- Bioinformatician
- Clincial trial design
- Computational biologist
- Medical researcher
Career options
Your future
You will exit this course with a highly sought after combination of expertise in disease pathology, bioinformatics and biostatistics and will be equipped to become part of a rapidly expanding workforce on the cutting edge of medical progress. You will be well positioned for a career in research, the health service, the pharmaceutical, or diagnostics industries.
Your future career will improve the quality of life of patients through better healthcare, and smarter technologies to treat and manage diseases such as heart disease, diabetes, neurological disorders, cancer or immune disease.
Work placement / study abroad
A third year (optional placement year is available)
The placement provides a wide range of opportunities for students to experience professional work experience in an industrial, hospital or university environment.
Students benefit by greatly improving their practical abilities, time management, organisational and interpersonal skills and hence their employability.
ApplyHow to apply Request a prospectus
Applications to full-time undergraduate degrees at Ulster are made through UCAS.
Start dates
- September 2019
Fees and funding
In this section
Fees (per year)
Important notice - fees information
Fees illustrated are based on 19/20 entry and are subject to an annual increase. Correct at the time of publishing. Terms and conditions apply. Additional mandatory costs are highlighted where they are known in advance. There are other costs associated with university study.
Visit our Fees pages for full details of fees
- Northern Ireland & EU:
- £4,275.00
- England, Scotland, Wales
and the Islands:
£9,250.00 Discounts available
- International:
- £14,060.00 Scholarships available
Scholarships, awards and prizes
Undergraduate Achievement Award from the Society for Endocrinology
Additional mandatory costs
Health Screening and Vaccinations
Costs for 2017: £35 - £155 dependent on vaccinations required.
Tuition fees and costs associated with accommodation, travel (including car parking charges), and normal living are a part of university life.
Where a course has additional mandatory expenses we make every effort to highlight them. These may include residential visits, field trips, materials (e.g. art, design, engineering) inoculations, security checks, computer equipment, uniforms, professional memberships etc.
We aim to provide students with the learning materials needed to support their studies. Our libraries are a valuable resource with an extensive collection of books and journals as well as first-class facilities and IT equipment. Computer suites and free wifi is also available on each of the campuses.
There will be some additional costs to being a student which cannot be itemised and these will be different for each student. You may choose to purchase your own textbooks and course materials or prefer your own computer and software. Printing and binding may also be required. There are additional fees for graduation ceremonies, examination resits and library fines. Additional costs vary from course to course.
Students choosing a period of paid work placement or study abroad as part of their course should be aware that there may be additional travel and living costs as well as tuition fees.
Please contact the course team for more information.
Faculty Office
Course Director: Dr Catriona Kelly
Administrative Co-ordinator: Mrs Brenda Plummer
For more information visit
Faculty of Life and Health Sciences
- The University endeavours to deliver courses and programmes of study in accordance with the description set out in this prospectus. The University's prospectus is produced at the earliest possible date in order to provide maximum assistance to individuals considering applying for a course of study offered by the University. The University makes every effort to ensure that the information contained in the prospectus is accurate but it is possible that some changes will occur between the date of printing and the start of the academic year to which it relates. Please note that the University's website is the most up-to-date source of information regarding courses and facilities and we strongly recommend that you always visit the website before making any commitments.
- Although reasonable steps are taken to provide the programmes and services described, the University cannot guarantee the provision of any course or facility and the University may make variations to the contents or methods of delivery of courses, discontinue, merge or combine courses and introduce new courses if such action is reasonably considered to be necessary by the University. Such circumstances include (but are not limited to) industrial action, lack of demand, departure of key staff, changes in legislation or government policy including changes, if any, resulting from the UK departing the European Union, withdrawal or reduction of funding or other circumstances beyond the University's reasonable control.
- If the University discontinues any courses, it will use its best endeavours to provide a suitable alternative course. In addition, courses may change during the course of study and in such circumstances the University will normally undertake a consultation process prior to any such changes being introduced and seek to ensure that no student is unreasonably prejudiced as a consequence of any such change.
- The University does not accept responsibility (other than through the negligence of the University, its staff or agents), for the consequences of any modification or cancellation of any course, or part of a course, offered by the University but will take into consideration the effects on individual students and seek to minimise the impact of such effects where reasonably practicable.
- The University cannot accept any liability for disruption to its provision of educational or other services caused by circumstances beyond its control, but the University will take all reasonable steps to minimise the resultant disruption to such services.


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Well not only is Tuesday Christmas day it is also a day where the supermarkets are closed, how will some people survive!!
Because of the Sunday trading laws today our local Tesco will be opening at Midnight Sunday evening and then staying open through the night and day until 7pm on Christmas Eve.
I mean I ask you if the shopping lemmings don't have what they want for Christmas already then there is no hope really. I am sure without doubt that some silly sod will be hammering on their grills tomorrow evening when they are shut demanding to be let in to shop!!! When they refuse I am sure the person will utter the immortal words "YOU HAVE RUINED CHRISTMAS!!"
You don't believe me? Well this is based on my experience of Christmas Eve in retail and I spent 17 years in the industry!!
They will be in there Christmas Eve with full trolleys and empty Christmas Spirit buying stuff that they don't need or for that matter often want plus in many cases what they can't afford, but the shops will be shut Christmas Day so they must buy stuff just in case!
Reading the paper today I see that Amazon is starting it's post Christmas & New Year Sale at 9am Christmas Day. They will be having I gather some short time offers through the day, I mean can't they just hold back one day?
I remember when Christmas was a time for being with family and friends, these days it's a time to out buy people gift wise then spend months moaning that you spent more money on them than they did on you. Some will moan about non-arrival of Christmas cards, you know those cardboard things that arrive from people you had forgotten existed and who you only hear from at Christmas.
Seeing the way some people behave this time of year in the name of celebrating a birth that allegedly took place in little more than a up market shed, it makes me relieved that I am an Atheist!!
Whatever your beliefs or otherwise have a great 25th December, remember those who are on their own and take care of yourself and those around you, and be grateful if your not working in retail on 26th December when all the madness starts again.

subset: commoncrawl


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Style Advice
Style Advice
The Portrush yarn dyed sports polo shirt adds a retro twist to a sport classic.
True to its sporting heritage, the Portrush features all the polo essentials, such as a button down neckline and collar, short ribbed sleeves and a dropped hem at the rear. We've added contrasting sports stripes to the chest and sleeves for an authentic retro look. This polo is finished in a stretch pique for a textured feel, with Mr Wills embroidery on the chest.
Think 80's, but actually stylish.
- Mr Wills embroidery
- Button up collar
- Stretch pique
- Contrasting yarn dyed stripes
- Our model wears a size M
Care Advice
- 96% Cotton, 4% Polyester
- Wash similar with colours at 40 degree
- Tumble dry low
- Cool Iron
- Do not dry clean
- Do not bleach


text:
The closer I get to the Halloween release of #Jacked the more tracks you will hear slipping out. This will be a free release featuring some remixes of my hottest #bmoreclub tracks. This next preview comes from Thunderbird Juicebox. He kills his version of me and Mike-Mike's "Loop That Shit" from "The Party Starter".
Thunderbird Juicebox - Shake That (Free 320kbps MP3 download) by Thunderbird Juicebox
Thunderbird Juicebox - Shinebox by Thunderbird Juicebox


text:
This coffee is brought to you by the women farmers of CECANOR, women who have increased their income, their ability to organize, and their leadership opportunities by participating in Cafe Femenino.
Above all, these women feel proud to instill in their daughters the expectation that they will grow up to become leaders in their community - just like their mothers.
Flavor Notes: Nutty, chocolate, maple syrupRoast: Medium-DarkOrigin: Peru Region: NorteVarietal: Tipica, Bourbon, Catimor, Gran Colombia, Villa SarchiGrade: SHB EP Altitude: 1000-2050MProcessing: Washed and sun driedCertifications: 100% Organic, Fair Trade, Cafe Femenino


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Abroad Surrogacy Clinics Deal Great Opportunities for Gays to Come
No doubt if you are a part of a gay couple that wishes to have your very own child, you …Read More
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Hold Your Children Enamel Wholesome Wonderful dental well being is a large asset on so many ranges. Because of quite …Read More
No doubt if you are a part of a gay couple that wishes to have your very own child, you …Read More
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Uterine Fibroids are the benign tumor inside the uterus or womb. They do not have any symptoms as such. Many …Read More
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What on earth is this and what is it for? Well, this is a medical procedure that is used for …Read More
Levonorgestrel IUDs are hormonal alternatives for the popular and effective 'T' design Copper, Silver or Gold intrauterine coil devices. While …Read More


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Why the New York Mets Should Not Trade for Robinson Cano
There was a ton of speculation today that it is quite possible that the New York Mets could acquire second baseman Robinson Cano from the Seattle Mariners. Closer Edwin Diaz could also be acquired in that deal. The Mets main target would be Diaz in that deal because he would upgrade that bullpen.
New York should be all in for getting Diaz but not Robinson Cano. The first reason why the Mets should not acquire him is because he is already 36 years old. The second reason why they shouldn't get him is because he still has five years remaining on his contract and Cano is owed $24 million each season.
If someone is going to get $24 million a year, they should save that for either Manny Machado or Bryce Harper.
The third reason why New York shouldn't trade for Cano is because he was suspended 80 games last season for PEDs.
I don't expect to him to have another solid season at his age. He did have a good year last season when he was on the field with a .303 batting average 10 home runs and 50 RBI's. His on-base percentage was .374.
The fourth reason why the Mets shouldn't trade for Cano is because Jeff McNeil has earned the right to be New York's opening day second baseman. He had a .319 batting average last season with three home runs and 19 RBI's, along with seven stole bases. His on-base percentage was .381.


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ONCAlert | Upfront Therapy for mRCC
Broad-Panel NGS Benefits Metastatic NSCLC
Published Online: Jan 10,2019
Michael F. Berger, PhD
Michael F. Berger, PhD, described the NGS landscape through the lens of his experience as the associate director of the Marie-Josée and Henry R. Kravis Center for Molecular Oncology during a presentation at the 13th Annual New York Lung Cancers Symposium hosted by Physicians' Education Resource®, LLC. The center developed the MSK-IMPACT (integrated mutation profiling of actionable cancer targets) comprehensive panel for sequencing 468 cancer-associated genes.1 The assay also evaluates tumor mutational burden (TMB) and mismatch repair deficiency (dMMR) or microsatellite instability (MSI).
"What might have been done in the context of an individual tumor type for a small core set of genes or mutations has now expanded to all different cancer-associated genes, knowing that mutations that may be more commonly observed in one cancer may also be less frequently observed in other cancers but also can provide informed treatment decisions for those patients," said Berger.
As an example, he cited BRAF mutations, which have been observed in approximately 50% of melanomas and have prompted the development of dual pathway–targeting agents, including the combination of dabrafenib (Tafinlar) and trametinib (Mekinist). In NSCLC, the same combination gained FDA approval in 2017 for patients with metastatic disease that harbors BRAF V600E mutations, which are found in 1% to 2% of lung adenocaricnomas.2
MSK now seeks to offer NGS testing to patients with meta- static cancer across all solid tumor types, particularly those with NSCLC, Berger said. He added that some patients with earlier-stage cancers may also undergo testing if they are treated through surgical oncology.
In NSCLC, such testing is growing increasingly relevant, notably because of novel therapies being developed for less prevalent gene fusions, Berger said in an interview with Targeted Therapies in Oncology. He cited the example of NTRK fusions, which have been identified in less than 3% of NSCLC cases. Larotrectinib (Vitrakvi), a selective tyrosine receptor kinase (TRK) inhibitor, and entrectinib (RXDX-101), an oral pan-TRK inhibitor, are among the drugs being developed in this space. 3
"The broad testing allows us to capture not just the common but also the rare mutations, and it also gives us information about more complex mutational signatures that are increasingly important for predicting response to immunotherapy," Berger said.
TMB is being explored as a biomarker in NSCLC. The FDA is currently considering a supplemental biologics license application for the combination of nivolumab (Opdivo) plus low-dose ipilimumab (Yervoy) for the frontline treatment of patients with advanced NSCLC with TMB ≥10 mutations per megabase.
Although dMMR/MSI is "very rare in lung cancer," Berger says patients with this signature may be candidates for pem- brolizumab (Keytruda), a PD-1 inhibitor that is approved for patients with unresectable or metastatic MSI-high or dMMR solid tumors who have progressed following prior treatment and who have no satisfactory alternative treatment options.
In describing the current landscape for NGS testing, Berger said there are 3 main test categories: hotspot panel, with amplicon capture of approximately 10 to 50 genes; cancer gene panel, with hybridization capture of about 100 to 500 genes; and whole exome sequencing, with hybridization capture of approximately 20,000 genes. At one end of the spectrum, hotspot panel testing is a lower-cost option that offers a fast turnaround, while at the other end, whole exome sequencing provides the greatest potential for discovery.
"There is a sweet spot in the middle, and this has been our approach," he said, referring to MSK-IMPACT. "It is cheaper, more rapid, more economical than the more comprehensive approaches, and in some ways more clinically suited."
At the same time, Berger said the choice of NGS strategy depends on clinical and practical factors. "There is really no one right approach. It depends on the disease, the lab, the resources available, the throughput in the laboratory, the turnaround time requirements, and cost consider- ations," he said.
One advantage of the MSK-IMPACT test, he said, is that it analyzes DNA from tumor cells and a matched normal control sample for comparison; in lung cancer, blood is the source used in the normal test.
"When we set up this program and developed the test, it was really with the goal of identifying individual muta- tions that might elicit responses to particular targeted therapies," Berger said. "But we can move beyond that, and that is enabled largely by the fact that we are sequencing both tumor and matched normal [samples]."
Thus far, more than 32,000 tumors have been sequenced with MSK-IMPACT, with approximately 200 additional tumors tested every week, Berger said. In 2017, the FDA approved the test, which is typically available only to patients treated at MSK, as an in vitro diagnostic.
Commercially available NGS tests approved by the FDA include the FoundationOne CDx assay, which tests for 324 genes; the Praxis Extended RAS Panel, which detects 56 mutations in RAS family genes; and the Oncomine Dx Target Test, which analyzes 23 genes and ROS1 fusions. The FoundationOne and Oncomine tests are approved as companion diagnostics for NSCLC drugs that target specific mutations.
- Evaluation of automatic class III designation for MSK-IMPACT (integrated mutation pro- filing of actionable cancer targets): decision summary. FDA website. accessdata.fda.gov/ cdrh_docs/reviews/DEN170058.pdf. Accessed December 7, 2018.
- Planchard D, Smit EF, Groen HJM, et al. Dabrafenib plus trametinib in patients with previ- ously untreated BRAFV600E-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial. Lancet Oncol. 2017;18(10):1307-1316. doi: 10.1016/S1470-2045(17)30679-4.
- 3. Drilon A, De Braud FG, Siena S, et al. Entrectinib, an oral pan-Trk, ROS1, and ALK inhib- itor in TKI-naïve patients with advanced solid tumors harboring gene rearrangements: up- dated phase I results [AACR abstract CT007]. Cancer Res. 2016;76(suppl 14):CT007. doi: 10.1158/1538-7445.AM2016-CT007.
Clinical Articles
Broad-Panel NGS Benefits Metastatic NSCLC


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The City of Perry has a once a week collection operation for bulk waste. Bulk waste consists of household items that are too large to reasonably fit in the garbage cart. The most common examples of bulk waste are furniture, carpeting, mattresses and appliances.
The bulk waste must be neatly stacked in a pile and not scattered and away from vehicles, poles, mail boxes and other obstructions adjoining your property. Carpet, padding and rugs should be rolled in three (3) foot sections and tied or taped and weigh no more than forty (40) pounds.
The total volume of bulk should not exceed six (6) cubic yards. If the pile is larger than this size, the City will collect the material at an additional fee to the customer.
Freezers and refrigerators must have the Freon reclaimed and a certification sticker placed on them as required by Federal law. Residents must contact a licensed heating/cooling specialist to reclaim the Freon before putting it out for collection. The doors must also be removed for safety reasons.
For items that are being disposed of that contain glass, please extensively tape and cross tape the glass to prevent it from shattering.
What We Cannot Collect
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- Paint or any liquid items.
Debris over seventy-five (75) pounds.


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Portfolio for Julian Barrow - Commissionaportrait
Painting only in oils, Julian Barrow is best known for his town and landscapes as well as paintings of country houses he has painted over 800 in his life. He is also a distinguished painter of interiors and conversation pieces. Born in Cumberland, Barrow has lived most of his life in London. After a very brief period at art school, he worked for a year as an apprentice in the restoration department of the National Gallery, followed by several years studying in Florence. More than thirty years ago he moved to Tite Street, where he works in a studio building occupied at various times by Whistler, Sargent, Glyn Philpot and Augustus John. Though based in London, he has travelled extensively, painting wherever he goes. His paintings hang in private collections throughout the world. He has exhibited more than twenty times at the Royal Academy and exhibits regularly in London, New York and the Middle East. He has been President of the Chelsea Arts Society for the last fourteen years.
I usually require 3 to 4 sittings for portraits of people and 3 to 4 visits for paintings of houses, landscapes, and interiors.
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Brian Sewell in the Evening Standard 1996;
"The marmalade glow of Julian Barrow's autumn is almost tolerable."


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Day 17 – Railay Is for Climbers
Dateline: Tonsai Beach, Krabi, Thailand, Saturday, March 20, 2010
Railay, in Thailand's Krabi province, is a rock climbing Mecca. People come here to try out some of the best climbs in the world. Now, every place claims to have "the best climbing in the world." In my estimation, though, Railay is a rock climber's paradise for at least three reasons.
#1 – The Rock Climbing
First, there's the rock climbing. It is indeed epic. There are rock faces in every direction so you can climb all day long in the shade so long as you keep switching venues. There's multi-pitch, bouldering, sport, and something called deep water solo where climbers go out in boats and climb without ropes on rock faces that hang out over the ocean. You won't get bored in Railay. New routes are being created all the time. People spend months here climbing their brains out. Which brings me to the second reason why Railay is special.
#2 – Thailand Is Cheap
Sure, Yosemite, the Swiss Alps, Vail, and New Zealand have great climbs. They are not, however, cheap. By Thai standards, Railay is a bit pricey. Most climbers, though, are not Thai. You can still find lodging for under seven bucks and have a meal for two. I've even seen people camped out in tents on Tonsai Beach. If you bring your own rock climbing gear, your daily expenses would run you about $15 a day. Imagine how much you could spend on booze.
#3 – Location, Location, Location
In my experience, rock climbing areas are very pretty. When you get high enough, you have expansive views of whatever countryside or desert or valley you're climbing over. The views here are quite nice. You climb over bays of crystal clear water. You lay your ropes down on white sand. At the top of your climbs, you look down on tropical beaches, tropical trees, and tropical, topless, European sunbathers. I took one look at the climbs here and realized that regardless of how terrible you climb, you're going to look good against this backdrop.
#4 – The Rasta Vibe
This is one chilled out place. The icon of choice isn't Buddha, it's Bob, as in Marley. Seems like every Thai guide has dreads. If you visit the right bars, they serve joints instead of peanuts. Reggae culture reigns supreme.
I have no idea why this is the case. Perhaps it's the tropics. Perhaps it's because the Thai climbers here connect with Marley's hymns to the oppressed. Maybe they've just got some damn good bud. I don't know. I do know that it gives the already slow tropical life an even more relaxed feel. People seem friendlier. People seem high.
This is all well and good. I'm in a climbing holy place. I will climb. This, despite the fact that, on balance, I probably hate climbing.
Don't get me wrong. I like the feel of scrambling up rock. It's a puzzle for me. Hang on this, pull on that, squeeze on this, ascend into the heavens. There's something very rewarding about "solving" a wall. You can look down and know exactly how much you've accomplished.
Now, you may look at this and say to yourself, "HHhhhmm. . .call me crazy, but it sounds like you like rock climbing."
I don't. Scrambling up rocks is not rock climbing. To rock climb you actually have to have a little bit of strength and body control. Climbs are steeper. You cannot have the grip of an eight-year-old girl. I have the grip of a four-year-old girl with mono. I've been hanging on a wall, admiring my 10 foot achievement, and come to the realization that my wrist is cramping. Suddenly, I am hanging on for dear life, wondering if I'll bang my knee on a ledge before I hit the ground. This is usually a static position, which eliminates the climbing part of the experience.
Yes yes yes. I know I'm being melodramatic. I've only ever top roped, which means I have a rope that keeps me from hitting the ground and from even falling more than two feet. So, if the fear of death is removed, why do I not enjoy climbing?
Easy. I end up in a static position because I don't want to let go of the wall. Not because I don't want to die (though that's a little bit of it), but because letting go of the wall is failure. A good climber never lets go of the wall. They climb up with less protection than people like me. For them, failure to hold on means they're falling far. They will get hurt. They may die. They most certainly will lose some choice pieces of skin. That's a high price for failure.
To me, failure means humiliation. I hate humiliation. When I climb, someone is watching, if only the person holding the other end of the rope. It's rare, though, to climb with only one person watching. It's impossible at a place like Railay.
I have no problem with private failure. Shoot, the anonymity of academic grades certainly proved that. Failure in front of family and close friends is bad, but not life threatening. Failure in front of people is the opposite of fun.
For me, rock climbing is an exercise in public humiliation. Inevitably, I will have to admit defeat at least four times on a climb. I will have to hang on the rope for at least 20 minutes to rest. I will slip and lose my grip. People will see my hands and calves shake as I hug the wall for dear life, trying to figure out what to do next. People on the ground will wonder why I'm taking so damn long. I may not die, but I will want to. At least in that, I'd get a little respect.
People keep telling me that I should just chill out and have fun when I climb. Those people usually fall into two categories: 1) they are good at rock climbing and 2) they are female. If you're good at rock climbing, you'll inevitably think I'm exaggerating and that I'm not that bad. After all, you're good at rock climbing. To you, rock climbing is not that hard. You have the grip of a championship judo wrestler and the balance of the Empire State building. You do not realize that rock climbing might be difficult for others because to you it is like breathing. You cannot talk to me because you do not understand. You do not experience my horror. You will stand on the ground as I climb and wonder why it's taking so damn long.
If you're a woman telling me that I should chill out, that's because you have not experienced the humiliation of public climbing. There's a double standard at work here. Chicks that rock climb are cool. No matter how bad you are, men (though perhaps not women) will encourage you and give you props for throwing yourself repeatedly at the wall. Men dominate the rock climbing world, so you, as a female, have not experienced the embarrassment of repeated failure because, for you, the bar is lower. You just have to climb. That is success. This means you'll have initially enjoyed climbing and done it again and again and, over time, you will be good at rock climbing (see category #1). Then you will doubly not understand what I'm going through.
There's also an underlying male dynamic here. Men, back me up on this, but there's a competitive vibe to everything that we do. Men go to great lengths to not fail in front of their own species. This will sometimes lead to excessive drinking, driving too fast, and Mark McGwire. The pressure to do well in front of other men is intense.
Now, in most aspects of my life, I've come to grips (so to speak) with who I am. I'm good at some things and not others. I can live with that. I can put myself in situations, not do well, and be fine with it. That's usually because I'm either doing that activity with my friends or have repeatedly explained to the other participants that I suck and that they're going to have to live with it.
More often than not, though, I just avoid doing what I'm not good at. I don't play baseball. I don't try to take the lids off jars without assistance. I don't rock climb.
Did I mention that Railay is a rock climber's Mecca?
Today, Darrel and I checked out Tonsai Beach and found all the rock climbers. I'd rented a pair of shoes and used them for a total of 15 seconds. I tried to boulder a face, got tired, and hopped off. That experience cost me (81 cents) a second. I know hookers that charge less.
It was way too hot to do much. We spent the afternoon just hanging on the beach, eating, drinking, and napping on these mats that a restaurant had out on a deck overlooking the sea.
If you're wondering why I'm philosophizing more than recounting, that's because there's nothing to recount. The pic above is one of only two I took all day. If you look closely, you can see white chalk marks where climbers have climbed. You can also see quickdraws hanging from the overhang, which climbers hook their ropes into.
I am in Railay though and I will rock climb. Visiting Railay and not climbing is like visiting the Louvre and not seeing the Mona Lisa or going to Mardi Gras and not showing your boobs. As much as I suck at it, I'll gut out a route or two. If nothing else, because I just paid a guy to take me deep water soloing. That's right. Boat, ocean, rock face, no rope. This is a bad idea.
Stupid Travel Tip of the Day: Love rock climbing when you visit Railay.
Not So Stupid Tip: If you're climbing, consider spending a day or two at Tonsai Beach. The vibe is really chill and the accommodations are supposed to be cheaper. The beach isn't as nice and you're more isolated, but you'll probably meet a lot more climbers since most of them are there for the walls and not for the sand, surf, or the accompanying pricier accommodations.
Doris permalinkMarch 22, 2010 12:18 am
lol. At least you are trying!
I was just thinking about the rock climbing issue today. I have all the gear but haven't tried climbing again in about 3 years because I am TERRIBLE at it (something about my lack of attention to detail and inability to figure out that if I put my pinky this way instead of that, I can climb up the rock). Also I do not like being a beginner. Ever. At anything. But I am thinking about trying again…
Jason Oei permalinkSeptember 3, 2010 12:25 am
Mervyn! Obviously I'm way behind, but I can't believe you were there! That was my favorite place when I was an SM in Thailand. I seem to remember it only being a 3-4 hour van ride from Had Yai. Good to see that it recovered from the tsunami, had heard it got hit pretty hard. Safe travels!
Jason Oei permalinkSeptember 3, 2010 12:46 am
Oh yeah, guess it won't hurt to say this now that you've left Railay, but there is also another issue with those anchors: They've been finding that the rain/moisture creates a pretty good acid when it interacts with all that limestone (cave formations, right?) which just chews up those metal anchors and bolts. Good to know AFTER you leave, right?


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24 JUN - 1 JUL 2019 | Espinho, Portugal
FEST – New Directors | New Films Festival is an all-encompassing celebration of the new tendencies of world cinema. The event focuses on a competitive and non-competitive showcase of the most promising new figures and works from around the globe.
The 15th edition of the festival will take place between the 24th of June and the 1st of July 2019, in the seaside town of Espinho (Portugal).
The selection is divided into several categories which include Feature Film and Short Film competitions in the Fiction, Documentary, Animation and Experimental Non-Narrative formats. The event also includes non-competitive sections that range from retrospectives, national and regional showcases, open-air beach screenings and the exhibition of Transmedia and Virtual Reality content, only to name a few.
The festival is currently accepting first and second feature films (regardless of the age of the director) as well as short films by directors up to the age of 35 at the end of the production.
Candidates must choose one of the available submission categories. Do not worry if your film fits different categories (Ie: Hybrid productions), as all submissions will be considered for the different competitions. If your film is also eligible for the NEXXT competition (focused on academic productions) but you wish the film to be considered for all other competitions please mention in the comment section of the submission the academic institution where the film was produced. If you have any doubts at all please do not hesitate to contact us at firstname.lastname@example.com
Throughout the years' FEST has selected for its feature film competitions films such as Jonathan Glazer's "Birth"; Sean Baker's "Tangerine"; Carlos Marques-Mercet's "10.000KM"; Tobias Nole's "Aloys"; Anna Rose Holmer's "the Fits"; and Rúnar Rúnarsson's "Volcano", among many others.
FEST's Short Film sections are known for its wide variety of styles and filmic visions, having been throughout the years a platform for the launch of new artists such as Govinda Van Maele (Luxembourg), Christos Massalas (Greece), Mati Diop (France), Adriano Valerio (Italy), Patrick Vollrath (Germany), Ninja Thyberg (Sweden), Manuel Abramovich (Argentina), Daria Belova (Russia), Simon Mésa Soto (Colombia), Aga Woszczynska (Poland), Jela Hasler (Switzerland), as well as hundreds of other up-and-coming filmmakers.
FEST also includes a series of other activities that run parallel to the festival, in particular, FEST – Training Ground (one of Europe's largest film forums) and FEST – Pitching Forum (film project competition), and others. For more information please visit our website at www.fest.pt
a) GOLDEN LYNX (Fiction & Documentary Feature Length Films)
b) SILVER LYNX (Fiction, Documentary, Animation and Non-Narrative Experimental Short Length Films)
c) PORTUGUESE GRAND PRIX (Portuguese majority Short Length Films)
d) NEXXT (Academic Short Length Films)
e) FESTinha Sub 6 & Sub 12 & Sub 16 (Children & Youth Feature & Short Length Films)
f) AUDIENCE AWARDS (Feature & Short Length Films)
Rules and Regulations
FEST New Directors | New Films Festival
1.1 FEST – New Directors | New Films Festival is organized by FEST - Associação Cultural (also known as FEST – AC or FEST).
1.2. The 15th edition of FEST will take place in the city of Espinho, Portugal, between the 24th of June and the 1st of July 2019 with the following objectives:
1.2.1. Promote sustainable development of film, screenings and promoting new talents in this area;
1.2.2. Disseminate new innovative work and film discourses from around the globe, providing a privileged window into the world of New Cinema;
1.2.3. Create new audience for cinema;
1.2.4. Promote the interchange of experiences between participants in the event;
1.2.5. Elevate the skills of participants;
1.2.6. Promote the city of Espinho as a quality cultural tourism destination;
1.2.7. Offer a quality cultural event accessible to every individual.
2.1. FEST has two distinct types of competition, competitions focused on feature-length films (upwards of 55 minutes length) and competitions for short films (up to 54 minutes). These competitions are represented in the sections Golden and Silver Lynx, Nexxt, Portuguese Grand Prix and FESTinha.
2.1.1 The short film competition accepts short length films made by directors with no more than 35 years of age (including) on the last day of production;
2.2.2 The feature-length film competition accepts films that are first or second feature-length productions (regardless of the director's age);
2.1.3 The films must have been concluded after the 1st of January 2018 and they must not have been screened in previous editions of FEST — New Directors/New Films Festival.
2.1.4 Film submissions will not be discriminated in terms of theme, genre, race, creed or any other limitations, apart from the elements described in this regulations. As such, all submissions will be analysed with the same rigor and dedication;
2.1.5 Submissions which do not fit these requirements will be considered invalid automatically, and FEST reserves the right to not let the applicant know that his or hers application has been disqualified.
2.2 All films to be considered for selection must be submitted using only one of the following options:
2.2.1 Using our own page at FilmFreeway (https://filmfreeway.com/festival/FestNewDirectorsNewFilmsFestival), where the largest possible amount of information about the production should be made available. If you choose to not use the FilmFreeway streaming service, we would be thankful if the submitters would leave the download option activated, but this is not mandatory;
2.2 All links/online screeners must be made available until the 31st of May 2019. It is also obligatory that all films are made available with English subtitles (including Portuguese productions) unless if all dialogues are already in English
2.3 If the submitter has any problem completing the application or making the online screener available via streaming, he or she must get in direct contact with the organization via the following address: firstname.lastname@example.com between the 10th of September 2018 and the 25th of February 2019. FEST reserves the right to not reply to requests and queries sent outside of the mentioned period. The email title/subject MUST contain the title of the film and the name of the director in the title.
2.4 It is permitted for the applicant to submit more than one film (in separate entries); The candidate cannot submit the same film in different categories or genres, as described in point 2.8;
2.5 FEST – New Directors | New Films Festival's competition are structured in different sections, each with its own jury members. Each section, jury and award is structured as follows:
2.5.1 All Feature Length films selected for the Golden Lynx competition will be disputing the awards Golden Lynx for Best Fiction Feature Film; or Golden Lynx For Best Documentary Feature Film. These works will also be disputing the Audience Award for Best Feature Film;
2.5.2 All Short Films selected for the Silver Lynx Competition will be disputing the awards Silver Lynx For Best Fiction Short Film; or Silver Lynx Award For Best Documentary Short Film; or Silver Lynx Award For Best Animation Short Film; or Silver Lynx Award For Best Experimental Short Film. All these works will also be disputing the Audience Award For Best Short Film;
2.5.3 All the Short Films selected for the NEXXT competition, limited to films produced in an academic context, will be disputing the NEXXT award;
2.5.4 All the Short Films selected for the National Grand Prix (GPN or NGP), limited to Portuguese majority productions, will be disputing the National Grand Prix award;
2.5.5 All the Feature and Short Films selected for the FESTinha section, focused on content directed at children and teenagers, will be disputing one of the three possible awards: FESTinha Sub6; FESTinha Sub12; e FESTinha Sub16;
2.5.6 FEST will create 6 separate jury groups (between 2 and 5 members each), who will have total freedom, and will, not be subjected to any interference or suggestions by the organization, in the moment of choosing the winning films. These 6 groups will be formed under the following structure:
a) Fiction Feature jury;
b) Feature and Short Documentary jury;
c) Short Animation and Experimental jury;
d) Short Fiction jury;
e) NEXXT jury;
f) National Grand Prix jury;
2.6.7 The winners of the FESTinha competition will be defined in a different format, where a pre-defined group of children and teenagers, through a workshop method, will decide on the three winning films, without any interference by the organization which may put in question the independence and neutrality of the jury;
2.6.8 The two Audience Awards (one for feature and another for short films) will be defined through a ballot paper vote that is distributed in the beginning of the official screening, and collected at the end. The final result will obey to a size of audience ratio logic;
2.6.9 Only the films exhibited in the context of the Golden and Silver Lynx competitions will be eligible for the Audience Award;
2.6.10 The final jury attributes awards without appeal and according to rules based on general principles determined by FEST – New Directors | New Films Festival. The final jury has the right to not award any one of the prizes if the criteria, according their belief, are not met;
2.6.11 The jury may not choose to award more than one film in each category;
2.6.12 The jury may distribute a maximum of 2 Honourable Mentions per category, although it has the right to not attribute any mention if it sees fit;
2.6.13 Media representatives present at the event may provide a Film Critics' Award without the interference of the organization of the event;
2.6.14 The prizes consist on a special trophy, distributed after the event, if no representative of the film is present at the closing ceremony, which will take place on the 30th of June 2019 in Espinho.
2.6.15 The prize will be sent via post within a period of 6 months after the closing ceremony of the event.
2.6.16. Additional rewards are not guaranteed, and if confirmed will be made known via our website (www.fest.pt), together with a new set of rules specifically defined for that purpose, if necessary.
2.7 Film Submissions at FEST – New Directors | New Films Festival are dependent on a submission fee of 6€ for short and medium length films and 10€ for feature-length films. The payment will be completed using Paypal and the submission platforms mentioned above;
2.7.1 This payment will be reduced between the period of the 10th of September and the 10th of October 2017, when there will be an "Early Bird" promotion with the following prices: 4 Euros for Short Films and 8 Euros for Feature Films. All the submissions completed after this period will have to pay the normal fee, as mentioned on point 2.7;
2.7.2 All Portuguese majority productions are exempt of any submission fee in order for the organization to promote the participation of the Portuguese artists and industry members. This exemption does not apply to other Portuguese speaking nations and regions;
2.7.3 All productions from countries currently under sanctions by the European Union or the Portuguese Republic, or with significant obstacles to PayPal access or impossibility of international bank transfers, may be exempt of paying the submission fee. All of these situations will be dealt on a case by case basis, as such, it is vital that these candidates get in touch with the organization, before completing the submission, via this email: firstname.lastname@example.com;
2.7.4 If a candidate has any significant technical problem in the payment of the submission fee, he or she must get in touch right away with the organization via email (firstname.lastname@example.com) in order to initiate a discussion on alternative payment methods. These situations will be dealt with on a case by case basis and FEST reserves the right to not provide alternative to PayPal as a payment method;
2.7.5 If a candidate aims at achieving a fee waiver he or she will have to get in touch with the organization via email (firstname.lastname@example.com) argumenting to great detail the reasons behind his or hers request. FEST reserves the right to deny any Fee Waiver.
2.8 The applicant will indicate on the entry form the category of their film. Only one of the following options must be chosen: Fiction; Documentary; Animation; Experimental.
2.8.1 If the film in question is a hybrid, where different styles and genres are mixed, the candidate must choose one single genre;
2.8.2 FEST reserves the right to opt for a different genre then the one the candidate choose and indicated in the submission form;
2.9 The submission period terminates on the 25th of February 2019 at GMT. All applications submitted after the mentioned deadline may be automatically disqualified.
2.10 Once a film is submitted to FEST, it cannot, for any reason, be removed from the program by the person or institution who submitted it;
2.11 All films and materials sent to FEST — New Directors | New Films Festival will not be returned and will remain in the festival's archive, unless there is a previous written agreement between the applicant and FEST stating the contrary;
2.12 FEST is not responsible for any spelling mistake or wrong information provided in the application. The titles and names of filmmakers used in all promotional materials will always refer to the ones provided in the application. Equally, title changes made by the filmmakers after the submission, may not be possible to alter, as such the applicant recognizes this at the moment of completing the submission.
2.13 By filling in the form and sending the application and film, the applicant provides full legal authorization for FEST — Associação Cultural to exhibit the film in the festival and in public presentations.
3.1 The selection of FEST is made by a secret group of programmers which should not be contacted directly by the applicants; as such any direct dialogue with programmers can be regarded as an unfair advantage and can be a strong enough reason for FEST to disqualify the submissions
3.1.1 All information, questions, queries or sending of additional material or updated news of the film or filmmakers recent career must be sent to at firstname.lastname@example.com (The email MUST contain the title of the film and the name of the director in the title/subject). The organization will forward all sent information to the programming team.
3.1.2. Fest reserves the right to not share information about the chances of selection of a submitted during the period of analysis.
3.2 FEST will inform the applicants that have been selected for the competitive section by e-mail or phone, latest by the 31st of May 2019;
3.2.1 The organization of FEST reserves the right to not contact non-selected submissions, yet the organization commits itself to do all the necessary efforts to contact every single submitter if possible. The final selection will be published on our website: www.fest.pt
3.2.2 Fest reserves the right to not use the contact options and selection news services within the partner platforms.
3.3 FEST – Associação Cultural is not obliged to provide reasons for the non-selection of a film.
3.4 FEST – Associação Cultural is not obliged to cover screening fees, as such applicants recognize this situation at the time of submission.
4. EXHIBITION FORMATS, TRANSIT OF SCREENING COPIES and SCREENING DETAILS
4.1 Expenses for the shipping and screening of films are to be met by the film's applicants; unless there is a previous written agreement between the applicant and FEST stating the contrary.
4.2 All applications or film copies sent with remitted expenses to be paid at the destiny by FEST will be returned and considered invalid;.
4.3 The exhibitions copies must be sent by 1st of June 2019, unless if both parties have a written agreement claiming the opposite.
4.4 The festival accepts the following formats for exhibition: DCP, Blu-Ray, digital file .MP4 or .MOV, 1080p or 720.
4.4.1 All exhibition copies must have no embedded subtitles. An additional srt. file with the correct time codes and clear English subtitles must be sent along with the final copy, whenever the film in question does not have dialogues in English;
4.5 FEST reserves the right to define the date of the screening and does not guarantee that the date can be altered at the convenience of the applicant. Fest also reserves the right, in case of extraordinary reasons, to change the date and time of the screening at the last minute;
4.5.1 In case a film is awarded, it will be rescreened on the 30th of June 2019, without additional costs or fees.
4.6 All selected filmmakers will be provided with two free accreditations that give full access to all film screenings, Masterclasses and Workshops, with the exception of FEST – Pitching Forum;
4.6.1 All selected filmmakers have the right to submit, free of charge, one single project application to the 2020 edition of FEST – Pitching Forum.
4.7 All selected filmmakers will be provided with up to 10 tickets for the official screening, which must be requested by the 9th of June 2019.
4.8. FEST-AC cannot guarantee any support or reimbursement of travel, accommodation and food expenses by any member of the cast and crew of a selected film. The applicant recognizes this situation at the time of submitting the film.
5.1. All eventual doubts or omissions in the regulation will be solved by FEST — New Directors | New Films Festival following rules of equity and good and fair judgment.
5.2. All submissions to FEST — New Directors | New Films Festival translate full acceptance and no reservations in the terms of the regulation.


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Lazy show notes.…Continue reading
G.O.A.T. Bonus Episode #3
Right Wing History For August 5th.
Promo for Playing For Keeps
Lazy show notes
Bonus: Over at my writing blog, I was bored and had a little fun making up a "cast list" for the non-existent movie version of my …Continue reading
A review of my first podcast interview.
From my Dad:
Please remember I love you when you read what I have to say about the Mur Lafferty interview. I swear I mean this to be helpful.…Continue reading
Geek of all Trades Episode #3: I finally get some Pod-cred.
In which our illustrious host interviews his podcasting idol, finally makes his Schenectady Mailbox an official segment, announces a new one even though he doesn't have an intro for it yet, insists people go see The Dark Knight, and gives …Continue reading
G.O.A.T. Bonus Episode #2
It's late, I know. Sorry 'bout that. To make up for it, I'm including a bonus from the Goddess of Radio, Randi Rhodes.
300 colonists bound for New France depart Dieppe, France
(was at www.datesinhistory.com/cgi-bin/bigphp.phtml?v1=jul23)
Ford Motor Company sells its …
Geek of all Trades Episode # 2: I do in fact "got chills" and they are indeed "multiplyin'."
In which our illustrious host loses control, cause the power you're supplying, is electrifying. Also, he re-tells the origins of his nickname, reviews a movie (or perhaps 3), gives an update on a couple of his writing projects, announces a …Continue reading
G.O.A.T. Bonus Episode #1
This Day in History from the Point of View of a Right Winger for July 9th:
Napoleon annexes the Kingdom of Holland: https://en.wikipedia.org/wiki/First_French_Empire
The 14th Amendment: (was at www.nps.gov/archive/malu/documents/amend14.htm
Great Train Wreck of 1918: https://en.wikipedia.org/wiki/Great_Train_Wreck_of_1918
Geek of all Trades # 1: Indiana Jones and the Terrorist Fist Jab
In which our illustrious host gets all philosophical on everybody's asses, trips over himself trying to inform new listeners about what they can expect from the show (won't be doing THAT again for awhile), talks a little about music and …Continue reading
Due to circumstances beyond my control…
…Episode 1 of Geek of all Trades is going to be late. Mevio is down for Site Maintenance, and I have no idea how long it will be. Hopefully I can still get the show in the feed before Midnight …Continue reading
Episode 15: Ave Atque Vale, MILF & Cookies Podcast (T Minus 0. LAST SHOW!) [M&Cookies]
In which our illustrious host says goodbye to one show (and hello to another, cause he's nuts), bitches about the Associated Press, plays a sad song, talks about George Carlin, gives a spoiler-free review of Get Smart, and hopes for …Continue reading


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Gravity (Alfonso Cuarón, 2013)
Surprisingly, only a single image in Alfonso Cuarón's Gravity truly harkens back to Stanley Kubrick's 1968 film, 2001: A Space Odyssey. Adrift through the reservoirs of space amid satellite debris, spinning out of control with only her gasping breath offering comfort, astronaut Ryan Stone (Sandra Bullock) secures safe passage back to an American space station. Stripping herself of uniform in zero gravity she drifts in a fetal position, with Cuarón pulling away, allowing the Earthly light to encapsulate her form. Of all the visual sights that Gravity provides, it's this moment of maternal rebirth that suggests a momentary lapse in the film's hyperactive movement, giving a shout out to the Star Child imagery of 2001: A Space Odyssey. But whereas Kubrick's worldview ridicules humanity's universal intervention and penchant for destruction, Cuarón embraces those very same ideas, with questionable results.
The pick-yourself-up-by-your-bootstraps narrative that Alfonso and Jonas Cuarón adopt for Gravity suggests a measure of humanism but it's marred by overt simplicity. For all of its many technical flourishes, from its long takes to the impressive sound design, Gravity's narrative is of Earthly conceit. The ideas rarely expound upon items of larger thematic concern nor is there a sense of real gravity to its celebration of life. Simplicity for simplicity's sake is never something to hold against a film and often times striving for a measure of calculated simplicity can benefit a picture. But in Gravity's case, the unusual dichotomy of technical wonder only accents the problematic scripting. It's largely highlighted by George Clooney's shmoozing as Commander Matt Kowalski.
By interjecting comic notes to the cosmic aura, the jarring disconnect between the two worlds is never reconciled. Is this an attempt to alleviate the otherworldliness of the picture's cosmos and its humanistic intent? Or perhaps Cuarón is adopting Kubrick's mentality by suggesting that humans and space ought to be mutually exclusive? This might have been the case if there was a sense meditation involved in its structure - a little breathing room. But the aforementioned imagery of Bullock in the fetal position offers only the slightest glimpse into a larger framework. The remainder of the picture is largely an exercise in action filmmaking. Not meant as a slight, but to suggest that Gravity is benchmark in introspective filmmaking is laughable.
But as it is, Gravity is essentially a construct of perpetually thrilling action set pieces. Quite honestly, it wouldn't be too far a stretch to see a bit of Buster Keaton in some of the action choreography. Hell, there's even a sequence where Bullock skins the edge of a satellite with her fingertips, clinging on at just the nick of time that briefly recalls Harold Lloyd dangling for dear life in Safety Last!. But with so little in the way of thematic cohesion, Gravity has more in common with a recent Steven Spielberg outing, The Adventures of Tintin.
Back in 2007 when Cuarón, Guillermo Del Toro, and Alejandro González Iñárritu were dubbed "The Three Amigos" following the commercial and critical success of Children of Men, Pan's Labyrinth, and Babel, they sparked comparisons a trio of filmmakers from the 70s - notably Steven Spielberg, George Lucas, and Francis Ford Coppola. In a self-fulfilling prophecy, Cuarón embraces much of Spielberg's cinematic tendencies - Gravity is as narratively propulsive, overly sentimental and intellectually bankrupt as some of Spielberg's efforts. It works in spurts, with Cuarón's relentless pacing working within the confines of his 90-minute runtime.
Amid the sensory overload, it's Bullock who is the picture's true saving grace. One of cinema's great action heroines (look no further than Speed and Demolition Man to see her tower over her co-stars' masculine bravado), she diffuses much of the narrative constraints through subtle touches, punctuations in her voice, and a kind of sensual physicality. She runs through trenches of domineering masculine narrative exposition and, unfortunately, quite literally pulled along by man, but the fact that she's capable of overcoming these circumstances and turns her character into something substantial is a credit to her skill. Gravity has and will continue to be hailed as a great this and stellar that but my biggest takeaway was seeing a filmmaker at his most thematically bankrupt and an actress at her very best.
Rating: 6/10


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Critical Questions in the Wake of the Executive Order to Secure the ICT Supply Chain
In an effort to secure the digital supply chain for the United States, President Trump issued an executive order on May 15 prohibiting the trade of information and communications technology or services designed, developed, manufactured or supplied by "foreign adversaries." The Executive Order on Securing the Information and Communications Technology and Services Supply Chain states that the risk of using such technology and services constitutes a national emergency. Based on discussions with government leaders – such as the Attorney General, the secretaries of Treasury, State, Defense and Homeland Security, the U.S. Trade Representative, the Director of National Intelligence, and others – the Secretary of Commerce will determine which supply chain transactions pose a threat to the United States.
The impact of this executive order – not only on technology companies – is potentially huge. The butterfly effect in our global economy of these imminent supply chain shifts can not only create significant impact felt by consumers, but it places business leaders in the driver's seat to navigate some highly perilous terrain. Which begs the question: In light of this executive order, what minefields should these business leaders watch out for?
Contingency planning is key
This executive order is one of many market-influencing developments for which any business relying on a supply chain must prepare. But how do you plan for resiliency in the face of unknown geo-political developments, regulations and policies? As they should for any contingency, business leaders can take initial steps by:
You're likely thinking, "that's easier said than done." Well, I recently read an article about the impact of rising tariffs on farmers. One impacted farmer decided to switch careers to driving trucks because he saw it as a more stable opportunity to support his family. In many ways, it's much more difficult to pivot a business than a single career, but failing to take action in the face of a market change is a recipe for disaster.
The fundamental Questions
Business leaders must first arm themselves with solid data about their own business ecosystems. That starts with some crucial, fundamental questions. For example, which partners are the real lynchpins to delivering that business' products and services? And can this sourcing be diversified across the business' ecosystem to mitigate risk? Understanding the dynamics between internal applications and systems – in addition to external partners, suppliers and customers – will help ensure uninterrupted revenue streams.
In the face of this new executive order, as it relates to technology, the question is: will companies in the United States be able to dynamically transform their supply chain, and even find new and innovative ways of meeting their hardware needs? Will they take the opportunity to finally develop software or virtualize versions of the hardware – and perhaps embark on an entirely new business model? Time will tell.
The lesson in all of this: These are the types of questions every company that relies on – or is attempting to do – business outside of the United States should be asking themselves. To put it simply, can their business be as agile as a farmer-turned-trucker?
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EBN Dialogue / LIVE CHAT
EBN Dialogue enables you to participate in live chats with notable leaders and luminaries. Open to the entire EBN community of electronics supply chain experts, these conversations see ideas shared, comments made, and questions asked and answered in real time. Listed below are upcoming and archived chats. Stay tuned and join in!
Archived Dialogues
Live Chat 01/15: CPOs Re-Shape Their Business Roles
Increasingly chief procurement officers (CPOs) are re-shaping their organizational role to focus on creating results far beyond cost controls. A new IBM survey explores how.
Live Chat 11/12: Examining the Cyberthreat to Supply Chains
The number of cyberattacks is on the rise and hackers are targeting the supply chain. Drew Smith, founder and CEO of InfoArmor, will be on hand to discuss the reality of today's threat landscape and what to do about it.


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Marc Zabludoff
This title is not awesome because it's a silly pun. It's because there's actually such a creature as a hyracotherium! Say that five times fast. Then type it five times fast. 🙂 Are two hyracotheriums called hyracotheria? Might have to read the book to find out!
Even the author name is pretty cool on this one.
For the curious, he's a link to the hyracotherium Wikipedia page.