text:
Just one week after your Chad and Sherwood Forest Hospitals NHS Trust launched a campaign to raise £550,000 to fund a new scanner at King's Mill Hospital, medical are lining up to run miles for the cause.
Your Chad is backing the trust, which runs the Sutton hospital in its campaign to buy a gamma scanner with CT technology for its nuclear medicine department.
The scanner will enable more than 2,000 patients each year to have advanced scans, which could speed up the diagnosis of diseases like cancer, helping patients receive the right treatment faster and reducing the need for invasive procedures.
Craig Short, aged 38, a quality improvement officer at the hospital is planning to run this year's Robin Hood Half Marathon in Nottingham to help with the appeal.
Craig will run more than 13 miles around the city, past landmarks like Nottingham Castle and Wollanton Park.
Within minutes of the appeal launch, he had already decided this year he would run it to help build-up funds.
Craig said: "Running the Robin Hood Half Marathon is something I've done for the past two years and I have supported other charities over that time, such as fund-raising to have two defibrillators installed in my home village of Oxton.
"When I saw the new appeal for a nuclear scanner I decided straight away that I would support it this year through sponsorship for the half marathon.
Craig has said one of the main reasons is helping the campaign is to contribute to the hospital.
He said: "I work at King's Mill and live not a million miles away from Mansfield so it's a fantastic opportunity to be able to contribute to something that will make improvements to the future of our hospital and will benefit our patients.
"I hope to raise £500 in total and have already started training for the main event."
The Robin Hood Half Marathon takes place on Sunday, September 30.
It is hoped the new scanner will be in place and helping to diagnose patients by summer 2019.
Can you help raise funds for the much needed scanner?
You do not have to be running a half marathon like Craig to help raise money.
Some great ways to help meet the hospitals target is to host a cake sale or a sponsored car wash. Patients and staff at the hospital have said they need the help of hind hearted volunteers to meet the £550,000 price tag on the scanner.
Staff are already putting their heads together to come up with fund-raising ideas.
If you are planning to raise money get in touch and tell us about your good work and we'll feature you in your Chad – helping boost the amount you raise.
Remember every penny counts.
Do not hesitate you can reach your Chad on 01623 450283 or email us at email@example.com
Donations to the appeal can be made by texting 70070 and quoting SFHC18 to donate £5 or £10, online at Just Giving (www.justgiving.com/sherwoodforest) or by cash or cheque at the Community Hub in the entrance of King's Mill Hospital.


text:
First photos of shot in head Gabrielle
Five months after US Congresswoman Gabrielle Giffords nearly died, after being shot in the head by a gunman whose bullets killed six others, the first pictures of her released since the massacre show the smile of a woman recovering remarkably well.
The images were published on her Facebook page, having been taken the day before an operation to replace part of her skull last month. There is still much rehabilitation ahead for the 41-year-old despite promising signs. Her chief of staff, Pia Carusone, said last week she was some way from being able to hold a full conversation. "She is borrowing upon other ways of communicating," Ms Carusone said.
"Her words are back more and more now, but she's still using facial expressions as a way to express. Pointing. Gesturing. Add it all together, and she's able to express the basics of what she wants or needs. But when it comes to a bigger and more complex thought that requires words, that's where she's had the trouble."
She added: "When she is trying to come up with a word or a sentence and she's clearly struggling, putting everything she's got into it, sometimes she's not successful. When she is, there's a relief that comes across her face that she has found the word. But when she can't come up with that, it is absolute frustration."
Jared Lee Loughner, the 22-year-old who denies carrying out the attack in Tucson in January, has yet to be declared mentally fit to assist his lawyers or understand the charges he faces.

subset: commoncrawl


text:
Bronx, NY native Nya Lee teams up with Miami's legendary rap queen Trina for this lustful visual and remix of O.T. Genasis hit single "Thick." These two give a lyrical reminder of their assets both literally and financially speaking. It's rare that we get to hear strong, independent, self-sufficient, beautiful and talented female MC's on one record but they did it - will they spark a trend of more female collaborations - hopefully!
Nya Lee raps:
I'm the truth, he no lie, I'm what he fanaticize
Let him taste it oh my god, yeah he love it, oh my god
P**** on All Star nickname it Derek Jeter
Trina raps:
I'm that b****, I'm that one
A** round like 12 o'clock
In that blueberry Wraith b**** watch me drop the top
P**** pop, earth shake I'ma squirt it in his face


text:
Qatar National Bank – Ramadan Campaign for TV
Our client wanted us to explore the best ways to target future customers and reach a much younger audience. Basically, we were mainly to address clients – and their parents – about to open their first bank account. The idea was to make a commercial that would convince the whole family, as the TVC was to be aired during prime-time slots. The resulting TVCs were light-hearted and fun, understandable from various perspectives, thus rejuvenating and humanizing the brand and adding a fresh family-friendly image. This was the perfect opportunity for Nayla Al Khaja to show her directing skills with non-professional kids. In total, we produced and directed 5 TVCs.


text:
Webcamsex met de lekkerste dames uit Nederland. De geilste meiden zitten helemaal naakt achter hun webcam om met jou te chatten!
valushanice (22)
Very beautiful attractive young juicy coveted girl. I love communication on various topics, open is not complex. I will be glad to talk with you!
Name: valushanice
Age: 22
City: Charkov
I speak: EN
Build: slank
Hair color: bruin
Eye color: blauw
Appearance: blank
I like to eat Fruits, vegetables, chocolate and to drink Coffee with milk and red wine. My hobbies: Dance, strip plastic, playing the piano. My favorite music is Classical and jazz. I am hetero and I think Gentle, intelligent, purposeful, attractive are hot. Do you want to know more about me?
My favorite position is I always top! and my favorite spots are I like to have a rest in Montenegro. What I like about men Strong arms and attractive ass. Piercings: nee. Relationship: nee. Do you have a sex question for me?
I am blank. My character: Kind, sociable, passionate. My zodiac is steenbok. What I like about me: Charm, figure, sociability and sense of purpose. My lifes purpose is: Continuous improvement and achieve happiness!. My motto is: Perfectionist in life!. Do you chat a lot? ja. Do you smoke? ja. My turn-off is Ill-mannered, rough and greedy persons!. Do you want to tell me something?
Pay by phone or add credits to your account.
Call :phonenr € 1,40 p.m.
Enter the code and click "Send"
Upgrade your credits with a package. (Credits usable for webcam chat)
Create a free account on webcamsex.land and chat with women in your area.
Benefits for webcamsex.land accounts.
Free account in 30 seconds
Direct contact with amateurs
Send messages to amateurs
Cam cheaper
Safe payment via your own bank
Jouw account mist nog een gebruikersnaam. Vul deze hier in.


text:
written by Erica Quam
Last week, I wrote about choosing a word-of-the-year. This week I want to get real with you.
Setting an intention should come with a WARNING.
This isn't what most people talk or write about. You don't read about this as you're getting ready for all the excitement of the New Year.
When you first set an intention...the first thing you might notice are the things you DON'T want that come up.
Which may lead some people to begin to question their intention.
You may think things like...
- "Well, this clearly doesn't work."
- "There must be something wrong with me."
- "Yet another example of why I'm different."
Don't dismiss this powerful practice so quickly. Have a little more trust and faith to see your intention for 2018 through.
Think of yourself as a gardener. You're planting a seed for the year. The first thing that's gonna come up isn't the flower or the fruit. It's not even the stem or the leaves. The first thing that'll come up after you plant a seed is all the DIRT.
So, look out! Begin to pay more attention to the things that are unlike your attention that'll come your way...especially during these first few months of the year.
One of the coaches I work with chose the word, 'abundance' as her word-of-the-year. She wanted to put her focus on all the abundance she had in her life. She wanted to acknowledge opportunities, connections, comforts, and gratitudes.
Early in the year, she had an athlete in her office asking for an increase to her scholarship. She taught her team that scholarship conversations were best if they were between her and them. Not one another. She was the one who would be making decisions about scholarship - so it wouldn't be productive to talk about it with anyone else on the team.
When this coach didn't increase the athlete's scholarship, the athlete threw an absolute fit. She stormed out of the office. She made sure her teammates knew about it. She even criticized her own teammates who were on a higher scholarship amount than her.
The athlete's parents got involved. They went to her athletic director. Parents who had once been on this coach's side - thanking her for helping their daughter have such a great college experience - were now telling her all the reasons she wasn't a good enough coach.
This coach was definitely triggered.
She wanted to be liked. She wanted her athletes to believe they were being treated fairly. She wanted them to feel like they were on a level of scholarship they felt they deserved.
The coach felt horrible. Yet, she knew she had to stick to her own beliefs - instead of listening to all of the many outside opinions, judgements, and criticisms.
This athlete had improved...she just wasn't at the level to merit a scholarship increase. She didn't make the team's top relay. She didn't score at the conference meet. She hadn't made NCAA Consideration times. This athlete didn't meet the criteria for the level of scholarship she wanted.
This coach started to doubt herself and doubt her decision. The hardest part was the discomfort of knowing that this athlete was complaining about her and dividing the team. This young woman had formed her own mini-alliance. The coach could just feel it. The eyerolls during team meetings. The whispers off to the side.
The more triggered the coach got by her athlete...the more discomfort she felt. The more she focused on this situation and made up stories about all the things the team was saying, the more horrible she felt. She wanted to quit.
We talked about this situation during one of our calls. "There's no abundance in my life right now. My word-of-the-year makes me sad...I've taken it down off of my mirror. I feel like it's a joke!"
That's how intention works. It's what no one tells you. You're gonna have challenges that come up this year that will stare you in the face....just daring you to be triggered.
The most important thing is your awareness of these triggers.
- How much do you really want abundance anyway?
- Can you still see abundance - even through a challenging situation?
- What are your athletes really teaching you?
For this coach, once we reframed her situation, she felt a little more hope.
She acknowledged she was proud of herself for sticking to her expectations and not giving in. She decided she needed to pay attention to other athletes on the team a little more. I challenged her to either check in with the athletes who she thought were whispering and rolling their eyes...or let it go.
You can't get rid of everything that triggers you in life. You can become more aware of your triggers. You can begin to take your power back through your own self awareness.
This awareness builder can help everyone on your team. Teach your athletes that they can't control anyone else. The only thing they can control is their own reaction to things. Most of the time, people don't have power over you until you give your power away.
Talk about how you can take your power back once you start to become aware of how you get triggered and how you react to situations.
This can be as simple as asking them to keep a running list of what triggers them...for one week. Have them keep track of the times they get irritable, angry, frustrated, sad, or uncomfortable. They can keep this "trigger tally" on their phones, in a journal, or on a piece of paper they carry around for a week.
The next week come back together. Talk about it.
- What did they notice?
- Were there any themes that came up?
- What else did they learn?
Next, ask them what they can do about the things that trigger them. Write a few of their examples up on a dry erase board. For each example ask them to think one productive action they can take vs. one unproductive action they could take.
Sure - they can always fly off the handle...or bitch and complain about things that trigger them. Is this helpful? Is it productive? Do they feel any better afterwards?
Most of the time, (if they're really being honest) they'll answer no.
If they get stuck, on what they can do to handle things in a more productive way...you can start to teach them and coach them on more productive ways to manage the things that trigger them.


text:
Oyo set to host Amala fiesta, unveils logo, Ambassador
Oyo State government, on Tuesday, unveiled agenda to organise a three-day food festival tagged "Amala fiesta" also known as "Ajodun Oka", which will hold from December 15 to 17 at the Trans Amusement Park, Bodija, Ibadan.
This was disclosed by the Commissioner for Information, Culture and Tourism, Toye Arulogun, while addressing newsmen at the state secretariat, Agodi, Ibadan.
Arulogun disclosed that the ministry is collaborating with Tourist Care Hospitality Association of Nigeria (TCHAN), Ministry of Local Government, Association of Local Government of Nigeria (ALGON) Oyo State Chapter and Canteen Owners Association of Nigeria.
He also unveiled the fiesta logo which he described as a "summation of our food heritage and culture" and Gboyega Olatunji as Amala Ambassador.


text:
A dear friend recently introduced me to Catzorange after hosting a pop up with them at Maiyet in NYC. Maiyet is known for their high end, ethically crafted pieces, but they also carry a beautiful selection of local artisan goods. Catzorange being among them. The line of bags is handmade in Brooklyn by husband and wife team Johnny and Coco Mannix. Their thoughtful craftsmanship, purposeful designs and gorgeous styles are spot on.
The couple runs the show from start to finish, everything from making the bags to creating their visual content and managing the business. The creation of the line came about organically, as the couple searched for a more natural and calmer way of life.
Coco is from Berlin and Johnny a New York native, together they moved from Germany to a small apartment in Manhattans West Village. Few possessions and tiny quarters encouraged them to nurture their creativity, by designing and building out their space in order to fit their aesthetic. After a year, the search for a mellow life lead them to a farm in Amagansett, Long Island. During this time the idea for Catzorange started to take form. Cocos own bucket bag served as the inspiration, a daily carry all that she wore from farm to beach. The piece generated a lot of attention so making more just made sense.
The bags are made by coiling and stitching natural cotton rope. They come in two styles, the aforementioned bucket and a circle tote, both are available in multiple size options. I took the medium bucket bag on a trip to Kauai last month, it was perfect for lazy beach days, heading to nice dinners and mai tais at dive bars. The bags possess a sense of natural simplicity, they are effortless, but designed with intention. I love items that eliminate the need for more the way these bags do, their versatility makes them a wonderful everyday staple.
Shop online www.catzorange.com and follow along @catzorange


text:
Italian outlet Il Messaggero previously claimed that De Vrij, 25, has already agreed a deal to join United this summer.
But they now believe that any pre-agreement could count for little because the Dutchman is set to switch agents.
He is said to be considering ditching SEG, who brokered Memphis Depay's recent Old Trafford exit.
De Vrij was apparently seen having dinner with Pierpaolo Triulzi, the agent of Juventus starlet Paulo Dybala.
And Il Messaggero reckon the change could mean that the Red Devils will have to begin negotiations from scratch.
De Vrij joined Lazio from Feyenoord in 2014.
He has emerged as a key player for Simone Inzaghi's side, making 23 appearances in the italian top flight this season.
There are just over 12 months left to run on his contract at the Stadio Olimpico.


text:
You may add lots of music for your iphone and jam out with tunes all day long extensive. Stay away from having both equally your new music participant and telephone to the fitness center, and just choose your iphone. You'll be able to add several hours of new music on to your phone, and cycle unique music out effortlessly that may help it become simple in your case to enjoy your preferred tunes.
Visite Our Web page Listed here Academia do Importador, roupas importadas, revender roupas de academia: im2
Take terrific pics through the use of your headphone wire! The volume buttons can be employed to just take photographs now, therefore you can maintain the twine inside your other hand to maintain your photographs continuous and distinct. This method may even be used if you are resting your telephone on the stand.
A fantastic gain of having an apple iphone is that you will not ought to buy a GPS method. The apple iphone incorporates an accurate GPS procedure. Given that the iPhone's GPS process now is aware current area, simply put in the sought after desired destination, and you will receive concise instructions, equally as you should having a regular GPS program.
Visite Our Web-site Listed here Academia do Importador, roupas importadas, revender roupas de academia: im2
Your iphone can do nearly anything you wish it to. The phrase "there's an app for that" is partly tongue in cheek and partly real. Check out the application store for lots of fantastic ideas and items you could get started making use of your cell phone to accomplish, monitor or remind you of.
Should you have Siri in your most recent era iphone, keep in mind you must converse simply, plainly and slowly but surely. Should you talk far too fast, in a deep accent or mumble your text, she would not be able to understand you, and you may turn out being disappointed. Try and find out the phrases that she acknowledges effortlessly to make sure that you may have a simpler time utilizing her.
To make browsing the web on the iphone just a little less complicated, obtain a larger keyboard! You don't need to go out and buy a bigger keyboard, possibly. Rotate the apple iphone sideways, tap the deal with bar inside Safari, and voila! You have got a bigger, easier-to-use keyboard for more rapidly plus more successful typing.
Visite Our Internet site Listed here Academia do Importador, roupas importadas, revender roupas de academia: im2
There are some wonderful academic apps for kids accessible in the event you have an iphone. You can also find some terrific games to entertain your kids, and a few in the video games can also be academic. Should your child requirements extra help with math, studying or science, check out out which applications are available for his age and quality amount.
Will not load an too much amount of apps on to your Iphone. There are plenty of effectively considered out apps that could make your life much more nice and assist you get things performed. In addition there are lots of apps which can be a squander of virtual house and will only https://www.youtube.com/edit?video_referrer=watch&video_id=a6YZbqzu3ig.
Visite Our Web site Below Academia do Importador, roupas importadas, revender roupas de academia: roupas importadas
Almost done…
We just sent you an email. Please click the link in the email to confirm your subscription!
OKSubscriptions powered by Strikingly


text:
- Name
- Pyrazinamide
- Accession Number
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Description
A pyrazine that is used therapeutically as an antitubercular agent.
- Structure
- Synonyms
- 2-carbamylpyrazine
- 2-pyrazinecarboxamide
- Aldinamide
- Pirazinamida
- Pirazinamide
- Pyrazinamid
- Pyrazinamida
- Pyrazinamide
- Pyrazinamidum
- Pyrazine carboxamide
- pyrazine-2-carboxamide
- Pyrazineamide
- Pyrazinecarboxamide
- Pyrazinoic acid amide
- Pyrizinamide
- External IDs
- Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing EndUnlock Additional Data Tebrazid Tab 500mg Tablet 500 mg Oral Valeant Canada Lp Valeant Canada S.E.C. 1973-12-31 Not applicableAdditional Data Available
- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.Learn more
- Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.Learn more
- Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing EndUnlock Additional Data Pdp-pyrazinamide Tablet 500 mg Oral Pendopharm Division Of De Pharmascience Inc 1984-12-31 Not applicable Pyrazinamide Tablet 500 mg/1 Oral VersaPharm Inc. - an Akorn Company 1995-04-01 Not applicable Pyrazinamide Tablet 500 mg/1 Oral Mikart, Inc. 1992-06-30 2016-08-26 Pyrazinamide Tablet 500 mg/1 Oral Effcon Laboratories, Inc. 1992-06-30 1995-12-29 Pyrazinamide Tablet 500 mg/1 Oral American Health Packaging 2016-10-24 Not applicable Pyrazinamide Tablet 500 mg/1 Oral Clinical Solutions Wholsesale 1971-06-03 2017-06-15 Pyrazinamide Tablet 500 mg/1 Oral Department Of State Health Services, Pharmacy Branch 1995-04-01 Not applicable Pyrazinamide Tablet 500 mg/1 Oral DAVA Pharmaceuticals, Inc. 1971-06-03 Not applicable Pyrazinamide Tablet 500 mg/1 Oral Major Pharmaceuticals 1971-06-03 Not applicable Pyrazinamide Tablet 500 mg/1 Oral A-S Medication Solutions 1971-06-03 Not applicableAdditional Data Available
- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.Learn more
- Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.Learn more
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Rifater Pyrazinamide (300 mg/1) + Isoniazid (50 mg/1) + Rifampicin (120 mg/1) Tablet, sugar coated Oral sanofi-aventis U.S. LLC 1994-05-31 Not applicable Rifater Pyrazinamide (300 mg/1) + Isoniazid (50 mg/1) + Rifampicin (120 mg/1) Tablet, sugar coated Oral Remedy Repack 2010-09-15 2010-09-16 Rifater Pyrazinamide (300 mg) + Isoniazid (50 mg) + Rifampicin (120 mg) Tablet Oral Sanofi Aventis 1995-12-31 2017-03-29
- International/Other Brands
- Piraldina (Bracco) / Prazina (Armoxindo) / Pyrafat (Riemser) / Pyrazide (Sanofi-Aventis) / Tebrazid (Valeant) / Tisamid (Orion)
- Categories
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antiinfectives for Systemic Use
- Antimycobacterials
- Antituberculosis Agents
- Cytochrome P-450 CYP3A Substrates
- Cytochrome P-450 CYP3A4 Substrates
- Cytochrome P-450 CYP3A4 Substrates (strength unknown)
- Drugs for Treatment of Tuberculosis
- Drugs that are Mainly Renally Excreted
- Pyrazines
- CAS number
- 98-96-4
- Weight
- Average: 123.1127
Monoisotopic: 123.043261797
- Chemical Formula
- InChI Key
- InChI
- InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
- IUPAC Name
- pyrazine-2-carboxamide
- Indication
For the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents.
- Associated Conditions
- Pharmacodynamics
Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB). It is used with other drugs to treat tuberculosis. It is a highly specific agent and is active only against Mycobacterium tuberculosis. In vitro and in vivo, the drug is active only at a slightly acid pH. Pyrazinamie gets activated to Pyrazinoic acid in the bacilli where it interferes with fatty acid synthase FAS I. This interferes with the bacteriums ability to synthesize new fatty acids, required for growth and replication.
- Mechanism of action
Pyrazinamide diffuses into active M. tuberculosis that express pyrazinamidase enzyme that converts pyrazinamide to the active form pyrazinoic acid. Pyrazinoic acid can leak out under acidic conditions to be converted to the protonated conjugate acid, which is readily diffused back into the bacilli and accumulate intracellularly. The net effect is that more pyrazinoic acid accumulates inside the bacillus at acid pH than at neutral pH. Pyrazinoic acid was thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids. However, this theory was thought to have been discounted (PMID: 11914348). However, further studies reproduced the results of FAS I inhibition as the putative mechanism first in whole cell assay of replicating M. tuberculosis bacilli which have shown that pyrazinoic acid and its ester inhibit the synthesis of fatty acids (PMID: 17101678). This study was followed by in vitro assay of tuberculous FAS I enzyme that tested the activity with pyrazinamide, pyrazinoic acid and several classes of pyrazinamide analogs. Pyrazinamide and its analogs inhibited the activity of purified FAS I (PMID: 17485499).
It has also been suggested that the accumulation of pyrazinoic acid disrupts membrane potential and interferes with energy production, necessary for survival of M. tuberculosis at an acidic site of infection. Pyrazinoic acid has also been shown to bind to the ribosomal protein S1 (RpsA) and inhibit trans-translation. This may explain the ability of the drug to kill dormant mycobacteria (PMID: 21835980).
Target Actions Organism AFatty acid synthetase I (FASI)inhibitor Mycobacterium tuberculosis
- Absorption
Rapidly and well absorbed from the gastrointestinal tract.
- Volume of distribution
- Not Available
- Protein binding
~10% (bound to plasma proteins)
- Metabolism
- Route of elimination
Approximately 70% of an oral dose is excreted in the urine, mainly by glomerular filtration within 24 hours
- Half life
9-10 hours (normal conditions)
- Clearance
- Not Available
- Toxicity
Side effects include liver injury, arthralgias, anorexia, nausea and vomiting, dysuria,malaise and fever, sideroblastic anemia, adverse effects on the blood clotting mechanism or vascular integrity, and hypersensitivity reactions such as urticaria, pruritis and skin rashes.
- Affected organisms
- Mycobacterium tuberculosis
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.Learn more
Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.Learn more
Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.Learn more
- Drug Interactions
Drug InteractionUnlock Additional Data (R)-warfarin The risk or severity of bleeding can be increased when Pyrazinamide is combined with (R)-warfarin. (S)-Warfarin The risk or severity of bleeding can be increased when Pyrazinamide is combined with (S)-Warfarin. 3,5-diiodothyropropionic acid The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Pyrazinamide. 4-hydroxycoumarin The metabolism of 4-hydroxycoumarin can be decreased when combined with Pyrazinamide. 5-androstenedione The metabolism of 5-androstenedione can be decreased when combined with Pyrazinamide. 6-Deoxyerythronolide B The metabolism of Pyrazinamide can be decreased when combined with 6-Deoxyerythronolide B. 6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Pyrazinamide. 7-ethyl-10-hydroxycamptothecin The metabolism of Pyrazinamide can be decreased when combined with 7-ethyl-10-hydroxycamptothecin. 9-aminocamptothecin The metabolism of 9-aminocamptothecin can be decreased when combined with Pyrazinamide. Abacavir Pyrazinamide may decrease the excretion rate of Abacavir which could result in a higher serum level.Additional Data Available
- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.Learn more
- SeveritySeverity
A severity rating for each drug interaction, from minor to major.Learn more
- Evidence LevelEvidence Level
A rating for the strength of the evidence supporting each drug interaction.Learn more
- ActionAction
An effect category for each drug interaction. Know how this interaction affects the subject drug.Learn more
- Food Interactions
- Take without regard to meals.
- General References
- Authors unspecified: Controlled trial of four thrice-weekly regimens and a daily regimen all given for 6 months for pulmonary tuberculosis. Lancet. 1981 Jan 24;1(8213):171-4. [PubMed:6109855]
- Authors unspecified: Controlled clinical trial of 4 short-couse regimens of chemotherapy (three 6-month and one 8-month) for pulmonary tuberculosis. Tubercle. 1983 Sep;64(3):153-66. [PubMed:6356538]
- Authors unspecified: A controlled trial of 6 months' chemotherapy in pulmonary tuberculosis. Final report: results during the 36 months after the end of chemotherapy and beyond. British Thoracic Society. Br J Dis Chest. 1984 Oct;78(4):330-6. [PubMed:6386028]
- Yee D, Valiquette C, Pelletier M, Parisien I, Rocher I, Menzies D: Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis. Am J Respir Crit Care Med. 2003 Jun 1;167(11):1472-7. Epub 2003 Jan 31. [PubMed:12569078]
- Boshoff HI, Mizrahi V, Barry CE 3rd: Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I. J Bacteriol. 2002 Apr;184(8):2167-72. [PubMed:11914348]
- Zimhony O, Vilcheze C, Arai M, Welch JT, Jacobs WR Jr: Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli. Antimicrob Agents Chemother. 2007 Feb;51(2):752-4. Epub 2006 Nov 13. [PubMed:17101678]
- Ngo SC, Zimhony O, Chung WJ, Sayahi H, Jacobs WR Jr, Welch JT: Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs. Antimicrob Agents Chemother. 2007 Jul;51(7):2430-5. Epub 2007 May 7. [PubMed:17485499]
- Shi W, Zhang X, Jiang X, Yuan H, Lee JS, Barry CE 3rd, Wang H, Zhang W, Zhang Y: Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science. 2011 Sep 16;333(6049):1630-2. doi: 10.1126/science.1208813. Epub 2011 Aug 11. [PubMed:21835980]
- External Links
- Human Metabolome Database
- KEGG Drug
- KEGG Compound
- PubChem Compound
- 1046
- PubChem Substance
- 46507478
- ChemSpider
- 1017
- BindingDB
- 228814
- ChEBI
- 45285
- ChEMBL
- Therapeutic Targets Database
- PharmGKB
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Pyrazinamide
- ATC Codes
- J04AK01 — Pyrazinamide
- J04AK — Other drugs for treatment of tuberculosis
- J04AM — Combinations of drugs for treatment of tuberculosis
- AHFS Codes
- 08:16.04 — Antituberculosis Agents
- PDB Entries
- 3r4x / 3r55 / 5fpd
- Download (73.6 KB)
Clinical Trials
- Clinical Trials
- Manufacturers
- Dava pharmaceuticals inc
- Mikart inc
- Packagers
- Amerisource Health Services Corp.
- A-S Medication Solutions LLC
- Belgomex Sprl
- Cardinal Health
- Comprehensive Consultant Services Inc.
- DAVA Pharmaceuticals
- Dept Health Central Pharmacy
- Mikart Inc.
- Murfreesboro Pharmaceutical Nursing Supply
- PD-Rx Pharmaceuticals Inc.
- Physicians Total Care Inc.
- Prescript Pharmaceuticals
- Remedy Repack
- Sanofi-Aventis Inc.
- Versapharm Inc.
- West-Ward Pharmaceuticals
- Dosage forms
Form Route Strength Tablet Oral 500 mg Tablet Oral 500 mg/1 Tablet Oral Tablet, sugar coated Oral
- Prices
Unit description Cost Unit Rifater tablet 3.1USD tablet Pyrazinamide 500 mg tablet 1.26USD tabletDrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
- Patents
- Not Available
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 192 °C PhysProp water solubility 1.5E+004 mg/L (at 25 °C) MERCK INDEX (1996) logP -0.60 HANSCH,C ET AL. (1995) logS -0.91 ADME Research, USCD pKa -0.5 Not Available
- Predicted Properties
Property Value Source Water Solubility 93.7 mg/mL ALOGPS logP -0.71 ALOGPS logP -1.2 ChemAxon logS -0.12 ALOGPS pKa (Strongest Acidic) 13.06 ChemAxon pKa (Strongest Basic) -0.68 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 3 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 68.87 Å2 ChemAxon Rotatable Bond Count 1 ChemAxon Refractivity 30.45 m3·mol-1 ChemAxon Polarizability 11.13 Å3 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon
- Predicted ADMET features
Property Value Probability Human Intestinal Absorption + 0.9813 Blood Brain Barrier + 0.9745 Caco-2 permeable + 0.7222 P-glycoprotein substrate Non-substrate 0.8219 P-glycoprotein inhibitor I Non-inhibitor 0.9709 P-glycoprotein inhibitor II Non-inhibitor 0.9971 Renal organic cation transporter Non-inhibitor 0.8985 CYP450 2C9 substrate Non-substrate 0.8861 CYP450 2D6 substrate Non-substrate 0.876 CYP450 3A4 substrate Non-substrate 0.7754 CYP450 1A2 substrate Non-inhibitor 0.8791 CYP450 2C9 inhibitor Non-inhibitor 0.9545 CYP450 2D6 inhibitor Non-inhibitor 0.9731 CYP450 2C19 inhibitor Non-inhibitor 0.9547 CYP450 3A4 inhibitor Non-inhibitor 0.9697 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9353 Ames test Non AMES toxic 0.9133 Carcinogenicity Non-carcinogens 0.9321 Biodegradation Not ready biodegradable 0.9602 Rat acute toxicity 1.8145 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9939 hERG inhibition (predictor II) Non-inhibitor 0.9617
- Mass Spec (NIST)
- Download (8.68 KB)
- Spectra
- Description
- This compound belongs to the class of organic compounds known as pyrazines. These are compounds containing a pyrazine ring, which is a six-member aromatic heterocycle, that consists of two nitrogen atoms (at positions 1 and 4) and four carbon atoms.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Diazines
- Sub Class
- Pyrazines
- Direct Parent
- Pyrazines
- Alternative Parents
- Heteroaromatic compounds / Carboximidic acids / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Hydrocarbon derivatives
- Substituents
- Pyrazine / Heteroaromatic compound / Azacycle / Carboximidic acid derivative / Carboximidic acid / Organic nitrogen compound / Organic oxygen compound / Organopnictogen compound / Hydrocarbon derivative / Organooxygen compound
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- pyrazines, monocarboxylic acid amide (CHEBI:45285) / a carboxamide (PYRAZINAMIDE)
- Zimhony O, Cox JS, Welch JT, Vilcheze C, Jacobs WR Jr: Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis. Nat Med. 2000 Sep;6(9):1043-7. [PubMed:10973326]
- Ngo SC, Zimhony O, Chung WJ, Sayahi H, Jacobs WR Jr, Welch JT: Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs. Antimicrob Agents Chemother. 2007 Jul;51(7):2430-5. Epub 2007 May 7. [PubMed:17485499]
- Zimhony O, Vilcheze C, Arai M, Welch JT, Jacobs WR Jr: Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli. Antimicrob Agents Chemother. 2007 Feb;51(2):752-4. Epub 2006 Nov 13. [PubMed:17101678]
- Schroeder EK, de Souza N, Santos DS, Blanchard JS, Basso LA: Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis. Curr Pharm Biotechnol. 2002 Sep;3(3):197-225. [PubMed:12164478]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Xanthine oxidase activity
- Specific Function
- Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Ha...
- Gene Name
- Uniprot ID
- Uniprot Name
- Xanthine dehydrogenase/oxidase
- Molecular Weight
- 146422.99 Da
- Moriwaki Y, Yamamoto T, Nasako Y, Takahashi S, Suda M, Hiroishi K, Hada T, Higashino K: In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochem Pharmacol. 1993 Sep 14;46(6):975-81. [PubMed:8216357]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Xanthine dehydrogenase activity
- Specific Function
- Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal...
- Gene Name
- Uniprot ID
- Uniprot Name
- Aldehyde oxidase
- Molecular Weight
- 147916.735 Da
- Moriwaki Y, Yamamoto T, Nasako Y, Takahashi S, Suda M, Hiroishi K, Hada T, Higashino K: In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochem Pharmacol. 1993 Sep 14;46(6):975-81. [PubMed:8216357]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- Uniprot ID
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
- Reid JM, Walker DL, Miller JK, Benson LM, Tomlinson AJ, Naylor S, Blajeski AL, LoRusso PM, Ames MM: The metabolism of pyrazoloacridine (NSC 366140) by cytochromes p450 and flavin monooxygenase in human liver microsomes. Clin Cancer Res. 2004 Feb 15;10(4):1471-80. [PubMed:14977851]
Drug created on June 13, 2005 07:24 / Updated on August 24, 2019 06:27


text:
Galway Bay fm newsroom – City councillors have voted to proceed with plans to acquire Lenaboy Castle in Salthill for use as a youth creative hub despite uncertainty over funding.
The property at Taylor's Hill, a former orphanage, is currently owned by the Sisters of Mercy.
The transfer of the building is being conducted as part of the redress scheme agreed nationally by the religious orders and the government.
Tune in to Galway Bay fm news for more details….


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Zender00 <danielpenn...@gmx.net>
|Re: Net.NNTP: Different behavior using different newsserver
|Thu, 12 Mar 2009 10:30:45 GMT
Hi Rory, I tried to use tcpdump to capture the output from my application and the server input. But I were not able to notice significant varieties... It seems that the server send empty responses. Maybe I have to access the nntp server in different ways? I already noticed that newsreader (e.g. GrabIT) perform a bunch of NNTP-Commands (Login, Disconnect, Login, Disconnect, Select Group ...) before they start the proper command... Kind regards, D. Penning Rory Winston wrote: > > Are you able to capture the output on the wire, so we can reproduce? > > Zender00 wrote: >> Hi, >> >> I got some troubles when I am using the org.apache.commons.net.nntp >> package >> with different (binary-)newsserver. >> >> On my first testserver all methods worked fine >> (Connecting/Authentication/Load groups/Load header of a group). >> >> But when I tried to use a different server (same kind of access) I get a >> completely different behavior. >> Connect and authentication works as the same but I does not receive any >> newsgroup. (Method NNTPClient.listNewsgroups() ) >> >> On another server I get once again another behavior: This server does >> send a >> lot of group information but I cannot receive any header from a >> newsgroup: >> NNTPClient.retrieveArticleInfo() returns always only an "-1". >> >> When I use GrabIT to scan these different server there are no problems, >> so I >> guess there is something wrong in my nntp package. >> Are there any known bugs within this package who can explain this? >> >> Kind regards, >> D. Penning >> > > > --------------------------------------------------------------------- > To unsubscribe, e-mail: firstname.lastname@example.com > For additional commands, e-mail: email@example.com > > > -- View this message in context: http://www.nabble.com/Net.NNTP%3A-Different-behavior-using-different-newsserver-tp22454348p22471961.html Sent from the Commons - User mailing list archive at Nabble.com. --------------------------------------------------------------------- To unsubscribe, e-mail: firstname.lastname@example.com For additional commands, e-mail: email@example.com
|View raw message


text:
NorthWind Partners is a global, strategic retained search advisory firm. The prime concentration of our work is with business & professional services, systems, solutions, and product companies spanning the aviation, aerospace and defense, healthcare, industrial, and technology sectors. We also have deep experience and relationships in the government contracting arena.
With over half a century of experience, we serve as trusted consultants evaluating, recruiting and coaching top tier executives. Our markets have realized and continue to undergo tremendous changes in the new global environment that has emerged in the 21st century and since 9/11, particularly in Asia, the Middle East, and Latin America. Our commitment is to build top leadership teams for select clients around the world.
The Partners at NorthWind are committed to directly conducting all searches while the majority of executive search firms rely predominantly on databases, less-experienced research/recruiting associates, or the Internet to perform the bulk of the project and deliver final candidates. Drastically outpacing the industry average, our success rate on engaged assignments is approximately 96% with 99% of executives placed maintaining a minimum tenure of 1 year.
Our team has successfully completed hundreds of assignments for clients and has had the opportunity to learn from the successes and failures of hundreds of companies. We gladly share the benefits of this experience with our clients and candidates.
With more than seven decades of combined experience, our team has successfully completed hundreds of assignments. Your trust in our expertise is appreciated.
Having amassed a wealth of knowledge from the successes and failures of hundreds of companies, we gladly share the many benefits of these experiences with clients and candidates alike.
Employers added 196,000 jobs last month as the U.S. unemployment rate remained unchanged at 3.8 percent, according to the most recent U.S. Bureau of Labor Statistics report released this morning. Wall Street analysts had expected an increase of between 150,000 and 200,000. The March gain is the 102nd consecutive month of job growth. The number of unemployed people
Employers added 304,000 jobs last month as the U.S. unemployment rate rose slightly to 4.0 percent, according to the most recent U.S. Bureau of Labor Statistics report released this morning. Wall Street analysts had expected an increase of about 165,000. The January gain is the 100th consecutive month of job growth. The number of unemployed people currently stands
Low unemployment and high demand for talent is feeding a recruiting environment where job seekers and new employees are more and more in control. CareerBuilder and SilkRoad have released the results of a new joint survey identifying job seekers' and new employees' expectations for hiring and onboarding. It is eye opening to say the least. Candidates today have higher
Executive search firm NorthWind Partners has recruited Paul A. Dillahay as president and chief executive officer of NCI Inc. He succeeds Brian J. Clark, who resigned from the positions to pursue other opportunities. Mr. Dillahay is a seasoned executive and results-oriented leader with broad financial, operational and consulting experience and a proven track record of executing transformational change initiatives, developing leaders,
RESTON, VA, January, 10, 2018 – Peraton has hired L. Roger Mason, recently a senior vice president of Noblis, as president of its newly formed Space, Intelligence and Cyber sector, effective Jan. 8, 2018. Mason will be responsible for strategy, program performance and growth in the new business unit, which aims to deliver advanced, mission-specific technology capabilities
RESTON, VA, January 9, 2017 — Dovel Technologies announced Jan. 4 the appointment of Damon Griggs as chief operating officer. In this newly created role, Griggs will oversee daily operations for the company, including building and scaling the organization, as well as ensuring customers' mission performance objectives are achieved. "As we continue to grow Dovel, it is critical
RESTON, VA, December 12, 2016 — Vectrus Inc. announced the appointment of Charles "Chuck" Prow as President and CEO, effective Dec. 6, 2016. He will also be appointed to the Board of Directors. Mattson and Company, a board advisory and executive search firm that specializes in senior executive talent selection and effective board governance, assisted in the
RESTON, VA, December 9, 2016 — Siemens Corp. announced Nov. 30 the appointment of Lisa Davis as chair and CEO, effective Jan. 1, 2017, to follow the retirement of current CEO Eric Spiegel. Judith Marks has been appointed Siemens CEO U.S., effective the same date. "Eric has grown Siemens' business and furthered our reputation in the U.S. as
RESTON, VA, December 8, 2016 — Abaco Systems today announced that it had recruited Mrinal Iyengar as Vice President, Product Management. Iyengar's most recent assignment was as Director, Advanced Systems at UTC Aerospace Systems (UTAS), one of the world's largest suppliers of technologically advanced aerospace and defense products, where she was responsible for product development of


text:
Dr.Sly Nedic emphasizes the importance of patient education in the successful treatment of this common skin disorder.
Melasma is a commonly acquired condition, occurring mainly in women, which symmetrically affects the skin's photo-exposed area. It is a chronic and relapsing disorder, despite treatment. It has a significant impact on a patient's social, family and professional life, and a huge impact on an individual's self-confidence.
Treating melasma is especially challenging, as it presents many obstacles for physicians and patients, including:
- poor understanding of the causes
- current, one-dimensional conventional treatment concentrates mostly on the skin itself, rather than understanding the internal contributing causes
- lack of patient education on the complexity of the condition
- lack of patient compliance and determination in sticking to prescribed procedures.
After trying numerous treatments with no visible improvements, melasma patients end up going from doctor to doctor, vainly hoping to find a miracle cure in the form of a single product or procedure.
Back to basics: Understanding the cause
From functional and integrative medical perspectives, we need to fully understand the cause of melasma so that we can treat it and its root causes, instead of only treating symptomatically.
Melasma is traditionally referred to as "the mask of pregnancy", due to its frequent appearance during pregnancy. It also predominantly affects women with Fitzpatrick III to VI (darker) skin types, in areas where UV radiation is highest. Hormonal changes are known to play a role here, as melasma is frequently found in women taking contraceptive pills. However, what happens in cases where no pregnancy or contraceptive pill use are present or where male patients are affected?
New understanding
Intriguingly enough, melasma runs in families irrespective of whether a man or woman gets the condition. The study showed that 70% of Latino men with melasma also had a family member with this condition.
Melanin fabrication in the skin is influenced by various internal and external factors that are more prevalent in certain genetically predisposed individuals. In addition to UVR, hormones and inflammatory signals can stimulate the melanocyte to either increase melanin production or increase transfer of melanin to keratinocytes. In men,the source of excessive hormonal influence is often different from that in women (like xenoestrogens, internal estrogen from aromatisation, etc.)
Our skin, especially the epidermis and keratinocytes, contains β-receptors (ER-β), which are highly sensitive to signaling from 17β-estradiol. This is the usual form of estrogen in reproductive women. Incorrect signaling, especially enhanced under UV radiation,upregulates the transcription factors that cause inflammation and increase melanin production.
However, there are more forms of estrogen, such as estriol (in pregnant women), non-bioidentical estrogen (in contraceptive pills), xenoestrogen (from environmental toxicity, cosmetics, etc.), and estrone(delivered by aromatisation). These forms can also have a higher binding affinity towards β-receptors than 17β-estradiol, explaining why Melasma is more prevalent under these circumstances.
One study showed a higher protein expression of β-receptors in the melasma-affected skin, which suggests estrogen participation in the pathogenesis of this disease, despite normal hormone levels in the blood.
Simply explained: estrogen under UV influence creates melasma in genetically predisposed individuals.
Since our environment is cluttered with xenoestrogens (phthalates, parabens, PCBs, BPN, preservatives, etc.) controlling melisma by only using products or procedures locally on the skin will inevitably lead to an unsuccessful outcome. Helping patients to understand this is of vital importance, as it will be reinforced during the integrative management of melasma. Patient compliance in avoiding xenoestrogens and detoxifying them is a big task but necessary!
Another important hormone in melasma pathology is cortisol. During persistent stress, cortisol –which is an anti-inflammatory hormone under normal circumstances – changes the immune response, allowing uncontrolled inflammation. Substantial evidence shows that melasma gets worse during stressful events and that inflammation also plays a role in melasma-affected areas. Inflammation is likely to play a big role in the sun-exposed skin because UVstimulates inflammatory signals, cytokines and the α-MSH hormone.This can also trigger melanin production and hyperpigmentation. Teaching patients how to control stress in order to help with melasma improvement is another big challenge for the integrative practitioner.
UV radiation
Melasma usually appears in sun-exposed areas, where UVR has either initiated or worsened pigmentation.It is interesting that melasma-affected skin shows signs of photodamage, when viewed under a microscope. With UV exposure, there is a direct and indirect way of stimulating the melanocyte to produce more pigment through inflammation and β-receptor signaling. Since this is so important, educating the patient on proper sun protection as part of their regular skincare regime is the most crucial step to diminishing melasma.
Patients need to understand that melasma is an incurable yet manageable condition. Management does not depend solely on prescribed local treatments or procedures – although they do play a significant part. Moreover, patients' compliance in avoiding sun exposure, as well as avoiding undesirable estrogen and xenoestrogens from the environment is essential for a more effective outcome. Regular detoxification, more organic food, and organic skincare would make a substantial difference; however, many patients are reluctant to implement these changes.
The integrative medical approach will include some oral supplements known as β-receptoragonists that, in a way, compete with harmful xenoestrogens. Persistence and dedication to receiving regular local treatments are also important, as one treatment is usually not enough. However, patient education and compliance are fundamental for effective results.


text:
Five Reasons Your Company Should Develop a Cyber Security Strategy Now
From a billion-dollar bank heist to massive leaks of private information, the headlines are littered with reasons why cybersecurity strategies are more important than ever. Though there are many, recent attacks demonstrate five glaring reasons why this is an area that all businesses should take very seriously.
1. Increased Sophistication
Sophisticated cyber theft plots have reached the level of skill found at top spy organizations and government agencies. Businesses are no longer facing independent amateur hackers. They now face professional cyber criminals and even state-sponsored entities. One should also note that it doesn't take a sophisticated attack to breach a system.
2. It Only Takes One
It only takes one weak link to penetrate a system. It doesn't matter whether that weakness is in the system or user-related. Companies rely more than ever on technology while the number of people capable of cyber attacks increases every day. No system or system user is perfect.
3. There Are So Many Different Kinds of Attacks
The internet has been likened to the wild west without a sheriff. Attacks can come in so many varieties, everything from custom, no-patch software to old-school phishing schemes. And don't forget about fake software updates and ransomware attacks, where hackers will freeze their victim's computers until they pay a certain amount of money. Many companies simply end up paying the ransom to get back to work, but besides the financial loss, it can take weeks to get everything back to normal.
4. The Internet Has Built-In Weaknesses
Billions of lines of outdated code are being used throughout the internet, each providing a potential point of system weakness. These security gaps are found in the apps on your phone, the social media sites you use, and the methods you use to pay for goods and services.
5. The Number of Attacks is Increasing – Fast
The Global State of Information Security Survey by PwC found that the number of cyber security incidents detected increased 48 percent from 2013 to 2014. The total number of attacks last year reached 42.8 million, or 117,339 attacks per day. And yet, as the frequency and costs of cyber-attacks rise, spending on security is actually falling – and has never averaged more than 4 percent of IT budgets in the first place.
You don't necessarily have to spend a lot more to keep your system safe, but because of the prevalence of cyber-attacks and potential for devastating losses, it's more than worth it to reevaluate your current system and make sure you're following today's best practices.
Carlos Coutin is Financial Services Technology Strategist at Envision Consulting, He is passionate about RIAs and entrepreneurship, something that led him in his quest to advise people like him, who want to make the best possible tech decisions without stress and with intelligence. Visit his website at www.envision-consulting.com. You can email Carlos at: email@example.com and follow him on Twitter @carlos_coutin.
comments powered by Disqus


text:
When Elon Musk revealed his intention to take Tesla private, he tweeted that it would be "way smoother and less disruptive" if the company were no longer on the stockmarket. Share-price swings can be a distraction for Tesla's staff, who own shares in the firm. What's more, being listed puts "enormous pressure on Tesla to make decisions that may be right for a given quarter, but not necessarily… for the long term". Musk's decision is bad news for ordinary investors. It highlights the "long, slow decline in the importance of public equity markets", says Fidelity's Tom Stevenson in The Daily Telegraph – and the flipside: what the consultancy McKinsey calls "the rise and rise of private markets".
A long-standing deal collapses
Ever since the Great Depression, the US Securities and Exchange Commission (SEC) has imposed regulatory burdens on listed companies, says Colby Smith on the Financial Times' Alphaville blog. The deal has always been that to get access to the savings of private investors, companies have to say what they're earning and how, "quarter after quarter". This is irritating administration for boards, but helps small investors evaluate what they're buying, giving them confidence in the business.
But now companies have backed away from this arrangement because they can get the money they need to fund their development from private markets. In the past few years, "the markets for private capital [have] become deep, sophisticated and global". Private-equity and venture-capital funds have proliferated and banks have become more involved in the early funding of promising new ventures. So companies now "have access to enough private savings of wealthy citizens".
As a result, smaller investors have less of a chance to benefit from the growth of companies, and therefore have less of a stake in the expansion of the overall economy. This is likely to undermine faith in capitalism. Jay Clayton, chairman of the SEC, has called the decline of the public company "a serious issue for our markets and the country". The availability of private funding has made going public less appealing. Instead, companies now list on public markets because their early owners want a liquid market for their own shares. "It's an exit for the big capital that's already there," says Smith. Many companies choose not to go public at all, or they wait much longer before taking the plunge.
The bathtub is draining
The stockmarket is like a "bathtub with the plug pulled out", says Stevenson. Listed companies are pouring out while new listings don't come in at the same rate. The number of stocks in the US has halved in the past two decades. The remaining companies tend to be larger and slower growers than previously, so pickings for investors are slimmer. Amazon floated three years after its inception, growing sales by 60% in the first year after it listed. Facebook took eight years to come to market, increasing revenue by a mere 36% in its first 12 months. "Guess which has been the better investment?"


text:
If I could have a wardrobe made up entirely of funky, oversized blazers I probably would. And the star of it would be this jumbo corduroy baby by super cool new brand Viden. The color is heavenly, and the texture and fit are so fun! There are a thousand different ways you can style this, which makes it a closet staple forever.
Jacket & Top: Viden NY / Trousers: Zara / Shoes: Zara / Sunglasses: MiuMiu


text:
6 months or more is a long time for a promo like Subway's Slice Chicken that cuts price cost and not the sandwich. The great deal is supposed to end last July 11, 2017 but we're so happy we still got it at 79 pesos each.
The said promo deal is really great! Because, besides of having a healthy eating diet, it is also good for your pocket.=)
I bought three orders of Slice Chicken Sandwich (see my picture..) last Sunday and we enjoyed eating this oven toast white meat, tender slice chicken ham with fresh crispy vegetables such as lettuce, tomatoes, green bell peppers, cucumbers, shallots, pickles, black olives and jalapenos in a white bread and honey mustard sauce. Only my daughter chose not with chili and olives. =)
By the way, Slice the Price! promo is still available as of this posting from its newest branch in Sykes Asia Bldg. Madrigal Avenue, Alabang, Muntinlupa City.


text:
Problem Statement in Thesis Papers – UK Writing Tips
I have ordered management essays from EssayFactory, and they are top quality. I saved a lot of time researching, and got the order completed well before the deadline. Recommended.
Our team of expert UK writers understands the challenges involved in composing a thesis problem statement. We have taken the time to familiarise ourselves with hundreds of thesis problem statement examples in order to ensure your paper is written at the highest academic level. We also want to share our secret writing tips to help you write the best quality assignment possible. If you do not have time to write your work yourself, you can order a custom paper from us. We always guarantee top-of-the-line work, delivered on time and error-free!
The problem statement thesis format must comply with all standards. This means that the writer must know all the rules and guidelines.
Tips from our professionals:
- It should help clarify why your topic is important
- It should flow directly to your thesis statement
- It should be easy to locate and one of the first few sentences in your work
24/7 customer
At EssayFactory.uk, we always take care to use all of these techniques when writing such opening sentences. However, our writers are experts in their fields, and such issues are very rare. Furthermore, we offer unlimited revisions to ensure customer satisfaction, something we prioritise above all else.
Another important element we offer is 100% custom and original work. We pride ourselves on our top-notch writers, and we always use the best plagiarism software to make sure that our essays are never copied or reproduced. We also pride ourselves in providing unique and creative approaches to your project, making sure it stands out as exemplary to your supervisor.
- Essay
- Research Paper
- Term Paper
- Case Study
- Choose Other
- Undergraduate
- Master's
- PhD
15 days +
10 days
7 days
5 days
3 days
2 days
24 hours
12 hours
6 hours
3 hours
How to Write the Problem Statement in Thesis Papers
Understanding how to make a problem statement in a thesis can be challenging. But, with the help of a great UK writer at EssayFactory.uk, the experience is always stress-free. We make it easy to calculate the amount you will be spending on your essay using the online calculator available on our website. Have a tight budget? No problem. We also take our data protection policies extremely seriously, and we keep your data for communication purposes only. Your security is incredibly important to us, and we will never share your information with anyone without your consent.
If you need a solution for a thesis or essay problem statement, look no further! We know how to effectively communicate the problem statement or theory in thesis writing. For a research essay, stating the questions your essay will address is the most important aspect of the paper and must be crafted with expertise.
We know exactly what is required to achieve the best marks on any paper for any academic level. Order from us today and get a custom paper that effectively deals with the questions at hand and provides solutions in a highly sophisticated way!


text:
It was announced that 'Thunderstruck,' starring Taylor Gray and NBA superstar Kevin Durant, will be released on DVD just in time for the holidays! Warner Brothers is bringing the family sports comedy to DVD/Blu-ray on December 4, 2012.
When Brian (Taylor Gray,) a hopelessly uncoordinated young fan magically switches talents with his basketball hero (NBA Superstar Kevin Durant, playing himself), he becomes the star of his high school team…while Kevin Durant suddenly can't make a shot to save his life. But with the playoffs approaching, Brian learns that being a true winner involves working hard at your own game, and he tries to make things right in time to prevent a catastrophic end to his hero's season.
The Blu-ray/DVD/UV Digital Copy will feature will include: KD's Klinic – Kevin Durant and Taylor Gray go behind the playbooks and teleprompters to discuss the film's complicated basketball elements and what it took to pull off their "talent exchange"; Coach Z – video interview with James Belushi; From Backboards to Clapboards; Tristin May's Video Blog; Deleted Scenes; and more!
Mark your calendars for December 4th!
'Thunderstruck' DVD Release Announced! is a post from: Taylor Gray Official Website


text:
Music Monday: Corigliano: Symphony No. 1
Come back when your screams aren't so raw around the edges. Edward Rothstein didn't actually write those words in his New York Times review of the New York première of John Corigliano's first symphony (written in 1988 in response to the AIDS crisis), but it's a sentiment that seems to be lurking everywhere beneath the surface. He opines that the piece "is extraordinarily aggressive: to show anger and pain, it shouts and screams and harangues in triple-forte range. These outbursts seem almost tantrums, they are so raw and musically unmotivated.". Later, he calls such gestures "vulgar"; he compares them unfavorably with other "musically sophisticated works" and complains that they "[rely] upon prepackaged emotional baggage" and fail to "enlarge the listener's perceptions". Could you mourn your dead in a way that's a bit more tasteful?
"Of Rage and Remembrance" is the work's subtitle, and that is very much its substance. It begins with rage, insistent strings bursting forth into snarling, dissonant brass chords. As these fade away, an off-stage piano taps out an old transcription of an Isaac Albeniz tango, a piece much loved by one of Corigliano's pianist friends who died of AIDS. The music lives in this reflective space for a while, but the loss becomes overwhelming and another furious onslaught ensues. A wild tarantella follows, depicting a certain music executive's descent into dementia while suffering from the disease. Patches of frenetic dancing alternate with yawning chasms of disorientation, as tho the music has found itself in a psychedelic dance club with death haunting its every step, trying to cover up the terror of unknown destruction with ever more desperate attempts to enjoy an increasingly horrifying present. (In the excellent and extensive program note on his website, Corigliano describes the end of this movement as "a brutal scream". It is not an understatement.)
Remembrance takes center stage in the extensive Chaconne (Giulio's Song). Giulio was an amateur cellist Corigliano had known since college, and several of the key motives in this movement are drawn from a recording of his improvisations made in 1962, well before he died. Eventually, a second cello joins in — representing Giulio's teacher, who also died of AIDS — and this ushers in a tapestry of remembrance, little themes and motives dissolving in and out of the texture, each representing a friend lost to the disease. Here, too, the burden of loss becomes overwhelming, and after a relentless funeral march, the music dissolves into another anguished attack on the senselessness of it all. A brief epilogue follows, in which waves of gentle brass chords suggest the timelessness of the open ocean, and the work ends in something approaching peaceful repose.
It was premature. More than 16,000 people died of AIDS in the United States in 1988, but that number would only continue to rise, peaking at nearly 41,700 in 1995. These were the years of "SILENCE = DEATH", when institutionalized homophobia* led to inaction and the infection of thousands. (President Reagan did not publicly utter the word "AIDS" until four years into the crisis, after more than 1,300 people had died. Behind closed doors, physicians opined that "if [AIDS] kills a few [homosexuals] off, it will make society a better place.". [AVERT.org]**) In the face of such indifference, there was nothing to do but scream, scream and rage and hope that if you were loud enough you could make them hear you, make them treat you like human beings. This is the context of John Corigliano's first symphony; it is a piece written by a gay man watching his community be torn apart by a disease it took years for medical and political institutions to pay attention to, watching thousands, tens of thousands of people die every year, with no end in sight. So are its outbursts vulgar? Perhaps, but no more so than a society that turns a blind eye to the sudden, horrific deaths of thousands.
Given the scale of this suffering, the depth of this fury, it may seem strange that I was almost completely oblivious to it until college. But in some ways, that's what it means to be queer. We are born apart, a perpetual diaspora. We find each other, in dance parties, at theatre club meetings, on online message boards, and we help each other figure out who and what we are. This is a horizontal learning — very few of us have parents who are queer; very few of us learn our history from early childhood from the stories our families tell. We have to learn our history from each other — we don't grow up with it — and that generational split is an aching severance. For people like me, AIDS was a distant bugaboo, a presence that haunted "how to come out to your family" guides as something your mother might be unreasonably afraid of. It wasn't, as it was for many queer people in my parent's generation, something that left their community in tatters.
Like everyone else who took his US Gay and Lesbian history class, I will never forget George Chauncey's lecture on AIDS. There were, of course, lectures and readings geared to situate the disease and its effects on queer politics and community in their historical contexts, but then there was the lecture where, instead of trying to get us to understand it intellectually, he tried to get us to feel it. He asked us not to take notes, just to listen. He put up a small collage of images on the screen, yearbook candids, that sort of thing. "This was so-and-so." A brief biography, maybe a paragraph of who this person was, how Chauncey knew them, what made them special. "And he died." Another slide, another name, another paragraph. "And he died." "And he died." "And she died." Brilliant people, writers, scientists, politicians. Dead, dead, dead. Ordinary people, funny people, human beings, just trying to make their way thru the world like everybody else. Dead. Dead. Dead.
It is difficult to cross this gap, difficult for someone in my generation to step back into the world of the late 80s, difficult to fully grasp what it meant to be queer in that context. Often, it feels like the work of doing history, sifting thru scraps and fragments to piece together an understanding of how the world was. I know barely a handful of queer people my parents' age — I haven't inherited these stories in the way I have tales of Jewish life in New England or farming in the Pacific Northwest. These stories don't come my way; I have to seek them out. I am so hungry for them, so hungry for any scraps that can tether the beautiful queer family I'm part of to some deeper foundation, some connexion with a past to call my own. Some of them are happy scraps, brave and dauntless people sticking it to the world to live authentic lives. And some of them are awful scraps, steeped in brutality, horror, and death. I'm hungry for them all.
And that's why this symphony is so important to me, more important, than I think it otherwise would be: It's a direct and palpable link to my queer heritage in the language that I've dedicated my life to mastering. It is a raw and unapologetic scream, a proclamation that we are here, we are queer, we are dying, but we will not be forgotten. I didn't live thru the AIDS crisis***, but I'm part of a queer community that has been profoundly shaped by its course; our collective queer inheritance in this country is incomprehensible without understanding this disease. And Corigliano's first symphony is a powerful contact point in that understanding. It is a work full of anger, full of bitter, almost nihilistic despair at being abandoned by the systems that were supposed to support us. I wasn't alive when it was written, but when I listen, I partake of the remembrance. I inherit the rage.
*AIDS is not, and has never been, a disease restricted exclusively to the queer population, but gay and bisexual men have always been disproportionately affected by the disease, and in the early years of the epidemic, it was often tied exclusively to those groups in the popular imagination.
**It would be more than a decade before the Supreme Court would rule "gay sex is icky" unconstitutional for the basis of legislation, which makes Rothstein's "vulgar" comment seem more tone-deaf than it otherwise might. I don't know enough about Rothstein to know his thoughts on homosexuality — my inclination is to chalk this up to simple oblivion, not covert malice, but it still stings more than it would if directed at a less charged work.
***I say, despite the toll the disease continues to take around the world, despite the fact that the CDC forecasts that half of college-age gay and bisexual men in this country will be HIV+ by the age of 50. AIDS is far from over.


text:
Scotmas Group: Most Entrepreneurial Exporter of the Year
Scotmas Group Listed in 'Philanthropic Top 30 for 2017' by Real Business
BQ Live Scottish Export Awards 2017
Hydro Nations Summit 2017 in Bangalore
Scotmas Recognised as a Finalist in the HSBC Scottish Export Awards!
Scotmas Agriculture : Reliable, responsive specialists
Scotmas Alpha Installation Avoids Major Capital Expenditure
Head Office
+44 (0)1573 226901
© 2018 Scotmas Limited. All Rights Reserved.
Use Biocides Safely – Always Read the Label
By continuing to browse the site you agree to our use of cookies.


text:
Ah, the "SODI" defense/
"Some Other Dude Did It" (drop a D for dumb)
According to Greenwich Police at about 6:00pm, Kenneth A Alfano, 63, of 174 Davis Ave in Greenwich was observed by a civilian in the area of Bruce Park and Davis Avenue driving erratically while drinking an alcoholic beverage.
According to Greenwich Police, in plain view, the arresting officer observed an open cooler containing three empty 11.2 oz bottles of Mike's Hard Lemonade and four empty 50 ml bottles of Jack Daniels Tennessee Whisky.
Mr. Alfano related to police that he drank one Mike's Hard Lemonade on his way from Danbury, made a stop at home and drank a second one on his way to Stop & Shop, and that the other alcoholic beverages were consumed by another passenger.


text:
If you are getting a tram in Melbourne today, be aware that your stop may be missed.
On Lygon Street, a swarm of bees have decided their home is stop 112 on the corner of Queensbury Street, so trams are not stopping there.
Both routes 1 and 6 are affected, so a little walk is ahead for those in the area.
Yarra Trams are working on the issue!


text:
570 East Leffel Lane
Springfield, OH 45505
The winning bridge at Clark State held 18 kg.
Dr. Mark Brooks Hedstrom
Dr. Brooks Hedstrom is a science teacher at Oakwood High School. He joined the Engineering Innovation team in 2017.
Information will be sent to enrolled students in June.
Commuting students are permitted to park in all parking lots since student parking is free of cost at Clark State Community College for students, faculty and staff.
All students will receive a Clark State Community College student ID card. This ID card will ensure access to the libraries, computer labs and dining hall during regular operating hours.
Students have access to the Springfield City Area Transit (SCAT) public transportation. SCAT runs daily from 9a.m.-5p.m. and can take students to Clark State Community College to and from many locations within city limits near the campus. For more information contact us email@example.com.
Springfield News Sun Photographer wins first place with photo of Engineering Innovation Spaghetti Bridge competition!
From the Springfield News Sun:
From the Clark State News Website:


text:
Psst… hey… hey you… HEY!
What're ya doin'?
Really? Why?
Because there's work to be done.
For what?
For me.
Because I promised myself I would do it.
What does it pay?
… You know, it's really nice outside. There's no humidity and the sun is shining.
… No one is watching. We could have cocktails on the porch. I think I saw some cheese in the fridge.
Shhh… I'm really trying to make some progress.
On what?
My story.
…Hey, I think the dog needs to go out.
The dog is fine.
… There are dishes in the sink, aren't there?
I did the dishes.
… You wanna work out?
…Can I help you with that?
Shhh. I'll get something done when you shut the fuck up.
Jeez! I'm just trying to help.
…So, how's it going? You making any progress?
What do you think?
I think that if you went outside and mowed the lawn that you'd at least accomplish something worthwhile today.
Maybe you have a point. Everyone is out there enjoying summer and here I am banging my head against the proverbial wall, again.
That's all I'm saying…
Uh huh.
… So you wanna read a book that someone with some actual follow through had the wherewith-all to complete? We could do it in the yard.
You dick!
Hey, don't get pissed at me, I'm only what you made me. Maybe if you got your shit together I wouldn't be able to get to you so easily.
Maybe if you had a little compassion…
I am only what you make me. Today I am this.
Why can't you be what I need?
Maybe I am.
It does't feel that way.
… Are you sure the dog doesn't need a walk?


text:
Bug: Navigating in an ArcMap Service is inconsistent
You can navigate an ArcMap Service by using the pan and zoom tools. When navigating a particular ArcMap Service the map pans or zooms to the wrong area of the map.
One reason for this is that the data frame of the ArcMap Service may be rotated. In this case the spatial reference system used by the ArcMap document (adjusted for rotation) does not match the spatial reference system of the ArcMap Service (not adjusted for rotation). This causes map navigation to be inconsistent.
If any of the data frames are rotated you will need to access the ArcMap document and undo the rotation. ArcMap Server does not fully support data frame rotation. There are no other workarounds.


text:
Shakespeare Special!
Speaking Shakespeare with PJ Escobio.
"But words are words. I never yet did hear that the bruised heart was pierced through the ear." ( Othello Act l Sc i)
Shakespeare never intended his work as literature, it was meant to be experienced. It was created for live actors to say on a live stage with an audience.
In this workshop the students will be both performer and audience. They will focus on speaking the text which gives them a more sensory understanding of the iambic pentameter. Through a series of imagination and group exercises they also gain a better understanding of the story's plot, themes, and characters. As audience members they begin to understand how to listen to the classical text without being overwhelmed by it. Our Instructor, PJ Escobio, is the Artistic Director of Shakespeare Frankfurt and has directed and performed roles from all but 5 of Shakespeare's plays.
PJ is offering 3 hour introductory workshops as well as longer courses involving 10 hours of tuition. Sessions can take place at The English Theatre or at school.
Please contact email@example.com for more information.
How do I book a workshop?
This is easy, simply fill in the online application forms. All workshops must be booked using this form. Your application will be processed and you should receive an answer within 3 working days.
Which workshop should I choose?
Have a look at the workshop choices here, we also offer workshops based on the productions happening at our theatre, as well as specialist workshops für Leistungskurs and Abitur groups.
If you don´t know which workshop to choose, then say so on the form. We will advise you on the correct workshop to suit your needs.
What happens when I book a workshop?
Your application is sent to the Education Department, the dates are considered and booked into our event calender, and appropriate pedagogues will be assigned to teach your workshop. Thereafter a Pedagogue will contact you to confirm details.
When can I have a workshop?
Workshops can take place during the week, Monday to Friday at the following times
Please do not ask for all available days but instead suggest 3 dates that would suit you and your students, this way we are sure to find a suitable date and a back-up date if necessary.
How much does a workshop cost?
We try to keep under or around €10 per student, generally workshops are €120 per pedagogue, most teachers prefer to have two pedagogues with one workshop of 12-15 students taking place in the bar and the other group work in the theatre, then they swap locations. Therefore we have two workshops running parallel and your students have an enriched experience.
For custom-made workshops, where our pedagogues have to research a new novel or play, an amount of €150 is charged per pedagogue.
We try to reduce the numbers so that each student receives enough attention, we recommend that one pedagogue works with about 15 students.
Can you come to my school?
Yes, we offer workshops to schools but an additional fee is charged to cover travel costs, and this depends on where the school is located. All we need is space. The school hall, canteen, large classrooms or even the playground can serve as workshop spaces.
Do I have to book in advance?
We only need about 3 weeks notice to organise a workshop. It is worth trying at short notice as well, we like to think of our teachers as lucky. The last two weeks of each term is when we are normally overbooked with workshops, so please book earlier, at least 6 weeks in advance for this period.
What do I need to prepare for a workshop?
What do I need to do in the workshop?
Have fun!
What do the participants need to bring with them?
Workshops can be thirsty work, so please bring something to drink and a snack. There will be a short snack break half-way through in the bar area, but drinks and snacks are not on sale.
In winter, we request that students bring sneakers or trainers with them because some styles of boots damage the stage and limit movement. It is also for the students´ safety so that they do not slip.
In summer sandals are fine, but not flip flops, as students risk slipping while on stage.
May I take photos of the workshop?
Absolutely! And your students may do so as well, with their fellow students permission.
Workshops for students
Tel. (069) 242 316-33
Fax. (069) 242 316-14


text:
Use a carving fork to serve pasta
Shalyapin Ivan/Shutterstock
"I can't get through a night without it. Except we don't use it to carve. Instead, we use it to deftly spin pasta and deliver a neat nest of noodles into a bowl. Using a large spoon in your left hand and the fork in your right, scoop the noodles with the fork and spin on the spoon until a nice bundle forms and set in the bowl—boom!—first class spaghetti." —Chef Ryan Hardy at New York City's Charlie Bird
Use a microwave to juice a lemon
"To juice a lemon, microwave it for 10 seconds. It breaks down the cells and makes the juice flow a lot faster. A good trick to keep in mind when trying to squeeze as much juices out as possible for a vinaigrette." —Chef/Partner Laurent Tourondel, New York's Arlington Club. Don't miss these other smart uses for kitchen tools.


text:
If anyone says that managing a group of people is a walk in the park, you probably should not trust them. Anyone with any responsibility for a team of workers knows that it can be a pain in the neck. But it doesn't have to be. You can make your management duties a lot more manageable with the right tech tools at your disposal.
Make work easy
An issue that most people are going to face at some point in their career is the problem of productivity. Sometimes, it is down to personal engagement or disposition. More often than you might think, however, it's a matter of having the right tools to handle your workload effectively. To that end, you should look at the tools that can make your employees a lot more productive. From time management software that will help them better organise their working day to automating software that will drastically reduce the amount of time spent on busywork, there's a lot you can do to make work easier for them.
Measure that productivity
Naturally, you can't just assume that any solutions you push through are going to do the job. A business that operates on assumptions will not operate well. Instead, make sure you're taking the steps to measure their productivity. For instance, you might set up a shared system where people set up logs of what they do during the day. Rather than making it a one-size-fits-all measurement, talk to them about the work they do and the most relevant key performance indicators to measure their productivity by.
Deal with real concerns
Not all your team's concerns will be about how much work they're getting done or how well they get it done. They face pressures from all sides and some of the most serious revolve around their health. For instance, it's a good idea to track how much extra work an employee might do with tracking software, to make sure they're not overworking themselves. But the right data can help you get at the real heart of their health using things like EAP solutions. That way you can assess and use data on their health to help them find working conditions that better fit their wellbeing.
Keep them in the loop
Any problem or concern is going to be made a lot worse with sub-par internal communication. Emails and messages are a great way to communicate quickly. But they're not always efficient. Especially if people aren't in the habit of cleaning their inboxes regularly. Think about teaching your employees how to use email management apps or alternative forms of communication for those messages that are an extra high priority. It's going to make your workplace a lot more free of mistakes and miscommunications, resulting in a much more efficient business.
Make it a lot easier to get in touch and to hold your team accountable. At the same time, look at how your tech can address their needs, from running health assessment programmes to helping them better deal with their workload.


text:
- Discover hidden toxins in your body with Dr. Hull's hair mineral analysis service.
This month's Healthy Newsletter delivers a Holiday Greeting for a Happy Holiday Season to all our Healthy Newsletter readers.
The articles for this month's newsletter focus on Splenda® and the effects diet sweeteners have on childhood obesity. Things are "heating up" with the artificial sweetener issue, so we'll keep you abreast of the latest news releases about both aspartame and sucralose as they become public.
I have included the first of two incredible case histories to make your holidays brighter. We have been working with two children in Europe suffering from what we believe is aspartame poisoning. When their mums removed all aspartame, these two children's health rapidly began improving. Both of these case histories are medically documented.
Also, we've updated SplendaExposed with three new articles. Stop by, see what's new and feel free to post your comments.
Wishing you and your loved ones a Happy Holiday. We'll be back in 2006 with my 10-Step Detox Program available on amazon.com, and a new book about aspartame is on its way!
- Introduction
- Tell Us Your Story
- Healthy Feedback
- The Hidden Chemicals In Splenda®
- Ditch The Fizz - Sugar-free Creates Obesity In Children
- Did You Know?
- Q & A with Dr. Hull
- This Month's Healthy Recipe
- Feature Article: Emma's Story
Posted December 2005 | Permanent Link
Visit Dr. Hull's Websites & Online Programs
Other Articles In This Category
- Introduction - April 2011
- Introduction - March 2011
- Introduction - February 2011
- Introduction - January 2011
- Introduction - December 2010
Online Hair Analysis Testing
Dr. Hull's Message Board
- Have something to say? Post a comment or discuss articles on Dr. Janet Starr Hull's Free Alternative Health Forum!


text:
How do I open a sqlite db file in my local disk? Follow
I tried double click it didnt work. Database support plugin is enabled.
4 comments
Are you using IDEA 13 EAP/beta or previous versions of IDEA?
13 EAp with ultimate trial
Am I correct that you have an SQLite data source already configured in Database tool window, and want to open a table data?
If this is your intention, then make sure the table (not only .dat file) is shown in the Database tool window. For this apply Synchronize action to the data source. After that select required table and press F4.
If you want something different, please, elaborate.
Problem solved. I wasn't be able to find the database tool window.
Please sign in to leave a comment.


text:
Retail industry suffers from 1,060 reported incidents of shoplifting every day
Recorded store theft has reached new epidemic proportions, according to the latest research from global loss prevention solutions provider Checkpoint Systems.
Analysis from recorded crime from every police force reveals that shoplifting in the UK increased by 7.1% in 2017 when a total of 387,092 incidents of retail theft were recorded – the equivalent of 1,060 every day.
Checkpoint Systems' research reveals that theft reached its pinnacle in March 2017, with 34,694 incidents reported.
Northumbria Police and Nottinghamshire Police recorded the largest annual increases, with 2,277 and 1,671 more incidents respectively – an average of 190 and 139 every month. However, it was Lincolnshire that recorded the highest percentage increase of 31.2%.
With approximately 43,000 retail establishments in London, the Metropolitan Police continue to handle the largest number of shoplifting reports, with 47,460 incidents recorded in 2017 – 130 every day.
Despite covering one of the largest areas of the UK, Dyfed-Powys Police recorded the lowest level of shoplifting, with an average of 25 incidents every month, yet there was still an increase of 19.1% in 2017.
Of the six forces reporting a decrease in shoplifting, Northamptonshire Police saw the number of incidents fall by 7.6% and the Police Service of Northern Ireland (PSNI) by 4.6%.
At a time when physical stores are experiencing unprecedented challenges, the figures make worrying reading for the estimated 330,000-plus UK retailers.
According to Checkpoint, the reality is that reported incidents are likely to just be the tip of the iceberg.
Many retailers do not have the resources to identify or apprehend thieves and the perpetrators simply continue to commit crimes until they are caught.
Neville Payne, VP of Merchandise Availability Solutions at Checkpoint Systems UK, which develops intelligent retail solutions that are designed to reduce shrinkage, said: "Recorded incidents of shoplifting as well as Organised Retail Crime are increasing, with thieves targeting stores that either don't have security antennas and protected merchandise, or those that have poor alarm compliance. Stolen products lead to incorrect inventory and out of stocks, which negatively impact the overall shopping experience.
"However, it doesn't just fall at the doorstep of the retailer, there need to be tougher penalties on those caught shoplifting, otherwise they will keep reoffending. And, as retailers are trialling more open store formats and flexible payments, the high street simply can't cope with a 'five finger discount' mentality becoming the norm."
Click here to view the UK shoplifting league table.


text:
Modern Desk
Designer: Plushpod
This piece has a stunning appearance. Modernize your home with this exotic desk!
This modern and exotic desk is made from high quality wood veneer. The cabinets and cylinder has a nice combination of walnut and chocolate on oak finish. Each cabinet has 3 drawers with plenty of space to store all your office supplies. Known for it's simplicity and sturdiness and it has a unique design.
The desk includes: two glass, two cabinets, and one cylinder.
An optional long cabinet is also available to complete this modern desk. The long cabinet comes with two doors and two drawers in the same matching walnut and chocolate on oak finish.
This desk and cabinet is custom made. We can tweak dimensions or do a whole adjustment. We can meet your needs! Please call us to get a custom quote based on your own dimensions, needs, and desires. Bring your ideas to us and we will make it.
Walnut and chocolate on oak
Exotic wood veneer on birch ply, glass
Entire desk
Left side: 81" W x 36" D x 30" H
Right side: 84" W x 18.5" D x 28.5" H
Left cabinet: 17" W x 22" D x 30" H
Right cabinet: 17" W x 17" D x 28.5" H
Cylinder: 14" Dia x 28.5" H
Long cabinet: 64" W x 18" D x 30" H
Made to order - 4 weeks approx.
Freight shipping charge may apply and we will confirm.


text:
Basic configuration of the core and realm applications
From OregonCore Wiki
In the introduction, we explained that there are two major applications that make up your server software. Each of these has a configuration file that allow you to tailor the way your server works. Although the system allows a considerable amount of customization, this article will explain only the settings that are required to start the server for the first time.
After running the server, you may want to change various other aspects of the configuration. Each section has an extensive list of the options, and possible settings in most cases, that will be available.
First, copy or rename:
- oregonrealm.conf.dist to oregonrealm.conf
- oregoncore.conf.dist to oregoncore.conf
Now, open those files with a text editor and properly read the description of each field and change it appropriately. You've just configured OregonCore.


text:
Seeing again: Nkosinathi Thomas Ngulube
Everything has already happened and nothing has happened. I can't think of a better way to explain my experience with Nkosinathi Thomas Ngulube's work, particularly a series of oil paintings showcased as part of the 'solo' program at the Candice Berman gallery.
I spend a lot of timeat this particular gallery and once in a while I'll see Ngulube's work. I admire the abstraction, composition, tone and hue but ultimately neglect the work…. I've always recognized the skill behind his work but never really felt moved by it.
Until one evening at home; I was sitting listening to music when I decided to go over some old art brochures. Two pieces caught my eye; the pianist and cheek to cheek. I was surprised to think that I had seen these oil paintings before because somehow, in that moment, they became some of the most impressive abstract art pieces I had seen in my life.
This experience of seeing again and feeling anew made me reflect on what emotions and experiences are made of. Everything is everything and things both exist and do not exist.
These two pieces which were so impactful to me yet remained completely unseen existed - they were made and real - but they also did not exist to me….the only difference between the two realities being time. "Time is the wrench that sabotages our understanding of the universe."
This is Ngulube talking on his work:
'I am greatly inspired by by my love for art, what I love, what I know, what is happening around me and my experiences. I suckle my experiences from my immediate existence, for to produce art I must be free within.'
Ngulube is a Joburg based artist practicing in various mediums; sculptural work, painting and printmaking.