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About Hard to Handle
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Quantitative Biology > Populations and Evolution
Title: Non Standard Finite Difference Scheme for Mutualistic Interaction Description
(Submitted on 2 Jan 2012 (v1), last revised 2 Jan 2015 (this version, v2))
Abstract: One of the more interesting themes of the mathematical ecology is the description of the mutualistic interaction between two interacting species. Based on continuous-time model developed by Holland and DeAngelis 2009 for consumer-resource mutualism description, this work deals with the application of the Mickens Non Standard Finite Difference method to transform the continuous-time scheme into a discrete-time one. It has been proved that the Mickens scheme is dynamically consistent with the original one regardless of the step-sizes used in numerical simulations, in opposition of the forward Euler method that shows numerical instabilities when the step size overcomes a critical value.
Submission historyFrom: Gianluca Gabbriellini [view email]
[v1] Mon, 2 Jan 2012 21:13:41 GMT (536kb,D)
[v2] Fri, 2 Jan 2015 12:12:33 GMT (536kb,D)
Link back to: arXiv, form interface, contact.


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About us
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Monday, August 19, 2019
Wednesday, 9 May 2018, 09:00 HKT/SGT
Helsinn Healthcare SA
Helsinn Group announces the launch of the IV formulation of AKYNZEO(R) (fosnetupitant/palonosetron) in the United States
Lugano, Switzerland, and Iselin, NJ, United States, May 9, 2018 - (ACN Newswire) -
Helsinn, a Swiss pharmaceutical group focused on building quality cancer care products, today announces that the intravenous formulation of AKYNZEO(R) (a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) for injection has been launched in the United States by its U.S. subsidiary, Helsinn Therapeutics (U.S.), Inc..
The FDA, on April 19, 2018, has approved AKYNZEO(R) IV in combination with dexamethasone in adults for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. AKYNZEO(R) for injection has not been studied for the prevention of nausea and vomiting associated with anthracycline plus cyclophosphamide chemotherapy.
Oral AKYNZEO(R) was previously approved by the FDA as a fixed combination oral agent in 2014 for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy, including, but not limited to, highly emetogenic chemotherapy. AKYNZEO(R) is an oral fixed combination of palonosetron and netupitant: palonosetron prevents nausea and vomiting during the acute phase and netupitant prevents nausea and vomiting during both the acute and delayed phase after cancer chemotherapy.
The bioequivalence of fosnetupitant and netupitant was demonstrated in a Phase 1 study and the safety of IV AKYNZEO(R) was established through a repeated dose safety study in cancer patients to potentially uncover adverse drug reactions that may appear during subsequent clinical practice. No anaphylactic and injection site reactions related to IV AKYNZEO(R) were reported in this study.
A repeated dose safety study is ongoing in patients receiving anthracycline plus cyclophosphamide to further establish the safety profile in this setting.
The prevention of CINV has significantly evolved over the past several decades. Currently the combination treatment of antiemetic medicines with different mechanisms of actions is recommended by the main international antiemetic guidelines for the prevention of CINV in most settings.
Giorgio Calderari, Helsinn Group General Manager, commented: "Helsinn's mission is to help people with cancer get the most out of every day. We're delighted that we are now able to make this therapy available in intravenous formulation. This is an important moment for Helsinn, as it allows us to bring an additional option to patients experiencing CINV in highly emetogenic chemotherapy treatment."
Paul Rittman, Chief Executive Officer of Helsinn Therapeutics, added: "We are delighted to launch the intravenous formulation of AKYNZEO(R) in the U.S market. One of our top priorities is to further expand the presence of Helsinn in the U.S. in order to help even more people who are suffering from the emetogenic side effects of cancer treatment."
About Akynzeo(R)
AKYNZEO(R) (netupitant 300mg/palonosetron 0.5mg) capsules was approved October 2014 in the United States and is indicated in combination with dexamethasone in adults for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy, including, but not limited to, highly emetogenic chemotherapy.
AKYNZEO(R) (fosnetupitant 235mg/palonosetron 0.25) for injection was approved April 2018 in the United States and is indicated in combination with dexamethasone in adults for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy.
Limitations of Use
AKYNZEO for injection has not been studied for the prevention of nausea and vomiting associated with anthracycline plus cyclophosphamide chemotherapy.
AKYNZEO is a combination of palonosetron, a serotonin-3 (5-HT3) receptor antagonist, and netupitant or fosnetupitant, substance P/neurokinin-1 (NK-1) receptor antagonists: palonosetron prevents nausea and vomiting during the acute phase and netupitant/fosnetupitant prevents nausea and vomiting during both the acute and delayed phase after cancer chemotherapy.
Warnings and Precautions
- Hypersensitivity reactions, including anaphylaxis, have been reported in patients receiving palonosetron, one of the components of AKYNZEO, with or without known hypersensitivity to other 5-HT3 receptor antagonists.
- Serotonin syndrome has been reported with 5-HT3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs. Serotonin syndrome can be life threatening. Symptoms associated with serotonin syndrome may include the following combination of signs and symptoms: mental status changes, autonomic instability, neuromuscular symptoms, seizures, and gastrointestinal symptoms. Patients should be monitored for the emergence of serotonin syndrome, and if symptoms occur, discontinue AKYNZEO and initiate supportive treatment. Patients should be informed of the increased risk of serotonin syndrome, especially if AKYNZEO is used concomitantly with other serotonergic drugs.
Adverse Reactions
- Most common adverse reactions for AKYNZEO capsules and injection: headache, asthenia, dyspepsia, fatigue, constipation and erythema
Drug Interactions
- Use with caution in patients receiving concomitant medications primarily metabolized by CYP3A4. The plasma concentrations of CYP3A4 substrates can increase when co-administered with AKYNZEO. The inhibitory effect on CYP3A4 can last for multiple days
-- Dexamethasone doses should be reduced when given with AKYNZEO. A more than two-fold increase in the systemic exposure of dexamethasone was observed 4 days after a single dose of netupitant or a single infusion of fosnetupitant
-- Consider the potential effects of increased plasma concentrations of midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) when administering with AKYNZEO. When administered with netupitant, the systemic exposure to midazolam was significantly increased
- Avoid concomitant use of AKYNZEO in patients on chronic use of a strong CYP3A4 inducer such as rifampin as this may decrease the efficacy of AKYNZEO
Use in Specific Populations
- Avoid use of AKYNZEO in patients with severe hepatic impairment, severe renal impairment, or end-stage renal disease
- Avoid use in pregnancy, limited data is available, may cause fetal harm.
For more information about AKYNZEO please see the full Prescribing Information.
About the Helsinn Group
Helsinn is a privately owned pharmaceutical group with an extensive portfolio of marketed cancer care products and a robust drug development pipeline. Since 1976, Helsinn has been improving the everyday lives of patients, guided by core family values of respect, integrity and quality. The Group works across pharmaceuticals, biotechnology, medical devices and nutritional supplements and has expertise in research, development, manufacture and the commercialization of therapeutic and supportive care products for cancer, pain and inflammation and gastroenterology. In 2016, Helsinn created the Helsinn Investment Fund to support early-stage investment opportunities in areas of unmet patient need. The company is headquartered in Lugano, Switzerland, with operating subsidiaries in Switzerland, Ireland, the U.S., Monaco and China, as well as a product presence in approximately 190 countries globally.
For more information:
Helsinn Group Media Contact
Paola Bonvicini
Group Head of Communication
Lugano, Switzerland
Tel: +41 (0) 91 985 21 21
[email protected]
For more information, please visit
and follow us on Twitter, LinkedIn and Vimeo.
This announcement is distributed by Nasdaq Corporate Solutions on behalf of Nasdaq Corporate Solutions clients.
The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.
Source: Helsinn Healthcare SA via Globenewswire
Topic: Press release summary
Science & Research
From the Asia Corporate News Network
Copyright © 2019 ACN Newswire. All rights reserved. A division of Asia Corporate News Network.
Helsinn Healthcare SA Releated News
Apr 20, 2018 22:10 HKT/SGT
Helsinn Group announces the FDA approval of the IV formulation of AKYNZEO(R) (fosnetupitant/ palonosetron) in the United States
Apr 17, 2018 08:00 HKT/SGT
Taiho Pharmaceutical and Helsinn Group present preclinical data at AACR Annual Meeting for a RET inhibitor under co-development as an attractive compound for anticancer therapy
Mar 28, 2018 21:50 HKT/SGT
Helsinn Healthcare S.A.: Winners of the inaugural Lyfebulb-Helsinn Innovation Summit & Awards in Oncology announced
Mar 2, 2018 09:00 HKT/SGT
Helsinn Healthcare S.A.: Eleven finalists have been chosen for the first ever Lyfebulb-Helsinn Innovation Summit & Award in Oncology
Oct 17, 2017 14:30 HKT/SGT
Helsinn Pharmaceuticals (Beijing) Co. Ltd. Opens Office in Shanghai, China
More news >>
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Today MmoGah is sharing with you a Madden 19 complete controls guide. This guide contains all the controls for Offense, Defense, Running, Catching, and Intercept on PS4 and Xbox one. If you are a veteran, then this year's offering only has a few new features to master, but if you are new to the game and want to catch up to the competition, then this is for you.
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Revealed at EA Play 2018, Madden is returning to PC for the first time in 11 years, which launches alongside the PS4 and Xbox One versions of the game. Gamers of Madden 19 will have the opportunity to play through several modes of the upcoming PC release, which you can see some of in this video featuring a match between the Cleveland Browns and New York Giants.
Devin Wade's story continues in Madden 19 with Longshot Homecoming along with Colt Cruise's personal tale from high school glory to his struggle to make ends meet. Longshot served as a tool to teach you the basics of playing Madden and the intricacies of the sport itself, the actual storytelling was well done.
Though it had leaked a few days earlier, EA Sports announced Wednesday that Brown will grace the front of Madden 19 standard edition which will be available world wide for Xbox One and PlayStation 4 on Aug. 10. Brown was long overdue for a cover as the NFL's reigning best wide receiver for five seasons.
Though it hasn't been officially announced, it seems pretty clear Pittsburgh Steelers WR Antonio Brown is the cover boy for the standard edition of Madden 19. On Tuesday, Steelers Depot tweeted out an image of several Madden 19 covers on which Brown is portrayed as the cover athlete.
The moment gamers have been waiting for has arrived. On Tuesday, EA Sports unveiled the Madden 19 ratings for every player. The reveal wasn't as long as it has been in previous years as EA only segmented the information in about four parts for this year's release. It began with the 7 99-overall-rated players and now, fans can look at the ratings for players on all 32 teams.
New York Giants running back Saquon Barkley and Cleveland Browns quarterback Baker Mayfield are at the top of their 2018 NFL Draft class. On Tuesday, EA released the ratings of the top rookies in Madden 19. Take a look at which players made it on to Madden 19's top rookies.
On Wednesday, EA Sports began their annual unveiling of player ratings for Madden 19. They are starting with the players who will begin the game rated a 99 overall. This year, there are 7 including New England Patriots legend Tom Brady. Please read on for the short list of the game's elite.
YouTuber Miguel "Gator" Lazada released a video showing off the top-rated players on all but three of the teams in Madden 19. Only three players — Rodgers, Aaron Donald and Antonio Brown — are rated 99 Overall. Brady has slipped to 97. Only Donald returns to the 99 Rating with which he finished in Madden 18.
Madden 18 added a new mode called Longshot. This year, Longshot is coming back with a new story called Longshot: Homecoming. Last Saturday, EA has released some screenshots from Madden 19 MUT, connected franchise, gameplay and Longshot Homecoming. Let's take it one mode at a time.
Early in May, longtime creative director of the Madden franchise, Rex Dickson stepped down from the position. According to the latest news from Polygon, Mike Young is the new creative director for the franchise. When you look at the visual quality of "Longshot," it seems safe to expect continued improvement in the graphics and presentation of the series under Young's influence.
EA has officially released the floodgates during this year's pre-release hype train. On Friday, EA Sports announced a load of information about Madden NFL 19 including the release date, Hall of Fame Edition cover athlete, pre-order details and some of the game's new features.
Jimmy Garoppolo made quite the impression on the San Francisco 49ers and the NFL after he was traded to the Bay area during the 2017 season. His stellar six-game stint landed him a new contract, increased fame and now he's getting a new face scan for Madden 19.
As we all know that Rex Dickson, the creative director of the Madden NFL series for EA Sports since 2012, has left the franchise and the company in early May, but his replacement hadn't been named. Carlos Guerrero will now be the senior producer for the series, which was a post previously held by Seann Graddy. It's unclear if Madden will have a creative director moving forward.
The football season is over, but we're just coming into the start of the Madden 19 release date hype. From now on, MmoGah will keep sharing all of the latest news and details related to the release of Madden 19 in this post, so please keep checking back to stay up to date with the latest information on Madden 19.
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Thursday's Wales National St David's Day Civic Service has been cancelled due to winter weather.
Most Rev John Davies, Archbishop of Wales, was supposed to preach at the service, calling on civic leaders from across Wales to follow the example of St David.
Archbishop John was expected to give the address at St John the Baptist Church in Cardiff.
However, a mini-service led by Canon Sarah Rowland Jones will be held instead for anyone who turns up.
Speaking of the importance of marking St David's Day, Archbishop John said in a statement, "St David founded communities where people worked, with whatever resources they had, to create trusting, supporting and lasting relationships in which everyone felt secure, supported and valued.
"It took ongoing hard work and a deal of self-discipline but he was, I believe, a model we would do well to emulate in our own communities today where some feel less than valued, vulnerable and insecure."
Stay up to date with the latest news stories from a Christian perspective. Sign up to our daily newsletter and receive more stories like this straight to your inbox every morning.


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WASHINGTON (8/25/14 12:05 p.m. ET)--Credit Union National Association interim President/CEO Bill Hampel announced this morning that John Magill, executive vice president for government affairs and special assistant to the president, will be leaving his position at CUNA on Sept. 5.
"John Magill has been a significant leader in CUNA's advocacy team for almost nine years, and we wish him well," Hampel said, adding," John will be sorely missed."
Magill, a 30-year veteran of Capitol Hill, joined CUNA in May 2006 as senior vice president of legislative affairs. He was promoted to the executive vice president post in September 2011.
"It's been a fulfilling, rewarding experience and an important part of my life," Magill said of his time at CUNA. He noted that it is expected that a new CUNA president/CEO will be named in the next few weeks.
"So the timing is right for me to step into my next challenge in our nation's capital, where so many of us are fortunate to work and call home."
As executive vice president for government affairs and special assistant to the president, Magill provided strategic counsel on legislative and political issues while overseeing the day to day operations of those key advocacy areas. He also handled a number of administrative and other related matters inherent in the daily operations of the CUNA Washington office.


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This HNA Producer Agreement (this "Agreement) is between Producer and Health Networks of America, LLC, a Nevada limited liability company, on behalf of itself and its affiliates (collectively, "Company"). For purposes of this Agreement, HNA's affiliates shall, at HNA's election, include any entity in which HNA holds equity ownership or has a written partnership agreement with or any other form of partnership implied or otherwise.
In addition, Producer acknowledges and agrees that Company may impose required privacy and security measures from time to time, including but not limited to, encryption of electronic devices that are used by Producer in fulfilling its obligations under this Agreement, and that it shall promptly implement such security measures following Company's disclosure of the same. Failure to promptly implement such security measures shall be considered a material breach under Paragraph 3 of Section C of this Agreement. Upon termination of this Agreement, or sooner if requested by Company, Producer will immediately deliver to Company any and all literature, documents, data, information, order forms, memoranda, correspondence, customer and prospective customer lists (obtained from Company), customer orders, records, cards or notes acquired, compiled or coming into Producer's knowledge, possession, custody or control in connection with his/her activities as a sales agent/ producer or sales representative of Company, as well as all machines, parts, equipment, rating tools and other materials received by Producer from Company or from any of its customers, agents/producers or suppliers in connection with such activities.
(b) the assignor is required to assign all commissions to the assignee as a condition of employment and (c) because of such relationship, it is appropriate for Company to report such commissions for tax purposes as income to the assignee.
a). Material default or substantive breach by Producer of one or more of its obligations under this Agreement (including any amendments)
b).any expiration, termination, or suspension of any license and appointment that is necessary for Producer to transact business on behalf of Company and that are required by any state or jurisdiction where Producer solicits sales of any Company Products, or Producer's commission of fraud, dishonesty, breach of trust, theft, misappropriation of money, or breach of any fiduciary duty.
c).Producer's failure to comply with any provision of this Agreement shall be material if Company determines that such failure affects Producer's ability to perform under this Agreement. Termination for cause shall not be Company's exclusive remedy, but shall be cumulative with all other remedies available at law or in equity. A failure to terminate this Agreement for cause shall not be a waiver of the right to do so with respect to any past, current or future default.
Addendum A – Product Authorization
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On Monday night, I hosted my first ever Brand Bootcamp for Food, Fitness and Wellness Professionals at Tournesol Wellness in New York City. In attendance were food bloggers, wellness professionals, an author, a naturopathic doctor and conscious sports content provider. We discussed how to differentiate their businesses from competitors, watched inspirational videos, journaled about unique value and more. In the end, each attendee left with a template for creating powerful messaging and tips for application that will help them attract their target audience as well as the inspiration to confidently move forward with their concepts.
Are you interested in scheduling a Brand Bootcamp for your food, fitness or wellness organization or networking group? Email me.
What is a brand bootcamp without a selfie? Look how awesome we are:
We also snacked on delicious treats provided by Amy and Brian and Heavenly Organics. Thank you to these awesome companies and YUM.


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SimDive allows you to simulate a dive orientation test with the use of the compass; the purpose of the simulation is to make a dive and be able to return to the starting point of departure, only by making use of a compass.
SimDive can serve both to learn how to use the compass during a navigation dive of orientation, and to keep good training practice. SimDive should NEVER be used during a real dive in water.
During the simulation dive you can meet both fixed obstacles (rocks) that must be circumvented, and fish, animals, plants, shells and flotsam, that have no interaction with the diver, but which may distract him thus making it harder to return to the starting point of the dive.
In order to increase the difficulties of performance, some of the conditions of immersion, such as visibility, conditions of day/night light, speed of navigation and intensity and direction of the current, may be changed.
At the end of each dive, you can also keep record of the track of the dive, and recall it subsequently, to visualize and analyze the path.
Please Note: In the LITE version some functions, such as setting the general conditions of the dive and the recording possibility, are disabled.
SimDive was created by Roberto Baroncini, diving instructor of Centro Sub Faenza (Italy), with the aim to facilitate classroom teaching of the theory of navigation dive of orientation.


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{meetup} Security & Development – Codemotion Tech Pills
Security & Development: a topic we all think about, in the tech world & beyond. What do we do about it though?
Join us on Thursday, January 26, 2017 for an evening of community conversations & exchange of thoughts, guest expert speakers sharing their view; all, around information security & development, two very interlinked topics, so relevant in today's world where everything is a potential hacking target.
Whether you are developer that wants to learn more, strengthen your security skills or get started thinking security by design; an infosec professional that is involved in application security, or helping with the development cycle, or someone who is involved in general with technology products or solutions, this is a great event to get some security thinking and meaningful conversations started!
• 18:30 Doors open
• 19:00 A developer's guide to the galaxy of OWASP Security Knowledge Framework
• 19:45 Principles of secure software development
• 20:30 Borrel / Networking
When: Thursday, January 26 – 6:30 pm
Where: Venture Cafe, Stationsplein 45, Rotterdam
Register now to save your free seat!Back to news list


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Despite surging volatility, a tumultuous six months and the 1.3% decline in the last week of June, US stocks, as measured by the S&P 500 total return index, showed a positive return for the quarter of 3.43% offsetting the first quarter decline and produced a 2.65% advance for the first six months of 2018.
World equity markets continued to have a difficult time, with the MSCI ACWI ex US declining another 2.61%, putting the year-to-date decline to -3.77%. Bonds continued to be under modest pressure reflecting the Federal Reserve policy of raising short-term interest rates, The Bloomberg Barclay's Aggregate Bond index dropping 0.16% for the three months and 1.62% decline through June.
Overall, the lower corporate tax rates from United States tax overhaul bill has raised earning's expectations while the tariff issues has raised uncertainty and contributed to increased volatility in the US Stock markets.
The US stock market, which represents well over a third of the world's publicly traded equity valuation, currently is fairing much better than the rest of the world reflecting our relative modest dependence on world trade. Our economy is consumer based and almost 70% of the consumer sector is service based. Countries like China, Germany and much of the world's emerging economies are much more trade and export oriented. Thus, trade tensions are causing more turbulence to their markets than they are in the United States.
But the biggest factor affecting investment performance in the US stock market hasn't been the exposure to tariffs, presidential tweets or even foreign exposure, it has remained growth stocks vs. value stocks at almost all capitalizations. The S&P 500 Value ETF (IVE) showed a return of minus 2.29% while the growth component, represented by the IVW ETF showed a positive return of 7.17% year-to-date.
Annualized Performance as of 6/30/2018 (1-year figures are not annualized)
IVE ETF NAV Value: 1-year 7.43%; 5-years 10.27%; 10-years 8.29%; expense ratio 0.18%
IVE ETV Mkt Price Value 1-year 7.46%; 5-years 10.29%; 10-years 8.29%; expense ratio 0.18%
IVW ETF NAV Growth: 1-year 20.40%; 5-years 15.78%; 10-years 11.50%; expense ratio 0.18%
IVW ETF Mkt Price Growth: 1-year 20.39%; 5-years 15.79%; 10-years 11.51%; expense ratio 0.18%
Performance data quoted represents past performance and does not guarantee future results. Investment returns and principal value Will fluctuate, and when sold, may be worth more or less than their original cost. Performance current to the most recent month-end may be lower or higher than the performance quoted and can be obtained by visiting www.ishares.com. Performance data quoted represents past performance and does not guarantee future results. Investment returns and principal value Will fluctuate, and when sold, may be worth more or less than their original cost. Performance current to the most recent month-end may be lower or higher than the performance quoted and can be obtained by visiting www.iShares.com. Market returns are based upon the midpiont of the bid/ask spread at 4:00 pm eastern time (when NAV is normally determined for most ETFs) and do not represent the retunrs you would receive if you traded shares at any other time.
Past performance is not a guarantee of future results. IVE ETF, IVW ETF and Index performance are not illustrative of Plumb Funds' performance.
Please call 866-987-7888 for performance of the funds or
Click here for most recent quarter-end performance for the Plumb Equity Fund.
Click here for most recent quarter-end performance for the Plumb Balanced Fund.
We were pleased to discuss the merits of this growth cycle on Fox Business News and Bloomberg Radio this last quarter. Despite the US stock market experiencing the second longest uninterrupted bull market in post-World War II history without a 20% decline, the S&P 500 is trading at a prospective P/E ratio under 17, which is about equal to its average level for the last fifty years and almost ten multiples lower that the pre-tech bubble levels of 2000.
Growth in the current cycle is highly weighted to communication technology, e-commerce and healthcare innovation. We believe that many of the companies driving and enabling these disruptive trends have developed very profitable business models that in many cases include significant recurring revenue. We believe that trends in these industries can continue to support both economic growth and stock price appreciation.
As always, we believe that knowing what we own and why we own these investments is the key to long-term investment results.
Thank you for the confidence you have placed in us.
Thomas G. Plumb
Important Information
Opinions expressed are those of the author as of July 31, 2018 and are subject to change, are not intended to be a forecast of future events, a guarantee of future results, nor investment advice.
Past performance does not guarantee future results. IVE ETF, IVW ETF and Index performance are not illustrative of Plumb Funds' performance. Please call 866-987-7888 for performance of the funds or or
Click here for most recent quarter-end performance for the Plumb Equity Fund.
Click here for most recent quarter-end performance for the Plumb Balanced Fund.
References to other funds should not be interpreted as an offer of these securities.
Mutual fund investing involves risk. Principal loss is possible. The fund may invest in small and mid sized companies which involve additional risks such as limited liquidity and greater volatility. The funds invest in foreign securities which involve greater volatility and political, economic and currency risks and differences in accounting methods. Because the funds may invest in ETFs, they are subject to additional risks that do not apply to conventional mutual funds, including the risks that the market price of an ETF's shares may trade at a discount to its net asset value ("NAV"), an active secondary trading market may not develop or be maintained, or trading may be halted by the exchange in which they trade, which may impact a fund's ability to sell its shares. The fund may also use options and future contracts, which have the risks of unlimited losses of the underlying holdings due to unanticipated market movements and failure to correctly predict the direction of securities prices, interest rates and currency exchange rates. The investment in options is not suitable for all investors. The Plumb Balanced Fund will invest in debt securities, which typically decrease in value when interest rates rise. This risk is usually greater for longer-term debt securities.
Diversification does not assure a profit nor protect against loss in a declining market.
The price-earnings ratio (P/E ratio) is the ratio for valuing a company that measures its current share price relative to its per-share earnings. The price-earnings ratio is also sometimes known as the price multiple or the earnings multiple.
You cannot invest directly in an index. The S&P 500 Index is an unmanaged market-capitalization-weighted index based on the average weighted performance of 500 widely held common stocks. The Morgan Stanley Capital International All Country World Index Ex-U.S. (MSCI ACWI Ex-U.S.) is designed to provide a broad measure of stock performance throughout the world, with the exception of U.S.-based companies. The Bloomberg Barclays US Aggregate Bond Index is a market capitalization-weighted index, meaning the securities in the index are weighted according to the market size of each bond type.
Plumb Funds are distributed by Quasar Distributors, LLC, distributor. IVE ETF and IVW ETF are not distributed by Quasar Distributors, LLC.


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The concern for detail makes perfection
"Details make perfection and perfection is not a detail", said Leonard de Vinci. By its concern for detail and its perfectionism, the Events department of Samsic Emploi enables your event to leave a lasting mark on the spirits of your guests.
Cocktails, company evenings, inaugurations, fairs, exhibitions: Samsic Emploi shapes your event to your image and relieves you of all constraints, so that you can benefit fully from the moment, in the company of your guests.
Our strict selection of personnel, welcoming and at ease in foreign languages, guarantees you a top-of-the-range service.
With its various partners, Samsic Emploi also advises you on the best way to ensure the success of your event, from design to logistics, depending on your budget.


text: For most of my first decade at Creative Learning Systems, it often felt like we were a lone voice in the No Child Left Behind wilderness. Schools were under enormous pressure to meet federally-mandated testing guidelines. Despite the best of intentions, educators often had little bandwidth for programs like the SmartLab. We all knew better, but the unfortunate reality was that authentic learning had, by necessity, become subordinate to standardized test performance.Read More


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Western Cape, Knysna meet 6 Year young Teacup Yorkie boy Bailey and
4 year old Yorkie female Bella.
They need a fantastic home together.
They have both been sterilized. They are in good health, playful and loving.
They are house trained.
They will be good with older children.
They are excellent with other dogs. They are not good with cats.
Yorkies for Adoption >


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DeepMind Health Q&A
How did the partnership come about?
Two years ago, Pearse Keane, a consultant ophthalmologist at Moorfields Eye Hospital, contacted DeepMind and requested a meeting to discuss whether artificial intelligence (AI) could help meet a growing clinical need to better analyse eye scans.
Pearse and Professor Sir Peng Khaw, Director of the National Institute of Health Research Biomedical Research Centre at Moorfields and the UCL Institute of Ophthalmology, met with the DeepMind Health team and were keen to initiate a collaborative research project between Moorfields and DeepMind.
What does the project involve?
Eye health professionals use scans of patients' eyes to detect and diagnose serious eye conditions and diseases.
At Moorfields we perform more than 5,000 optical coherence tomography (OCT) scans every week. It takes eye health professionals a long time to analyse these highly complex eye scans, which can impact on how quickly patients can be seen to discuss their diagnosis and treatment.
Our research project with DeepMind Health is investigating how AI technology could help us to analyse these scans. We hope this will lead to earlier detection and treatment of eye disease before lasting damage occurs.
What is artificial intelligence?
Artificial intelligence (AI) refers to a wide branch of computer science that attempts to build machines capable of intelligent behaviour.
What is machine learning?
Machine learning is a type of AI, which refers to the development of programmes that are able to act without being explicitly programmed. A programme will use a variety of techniques to build a mathematical description or 'model', based on the data shown to it and 'learn from' this data to perform a function, such as making a prediction or identifying specific pixels.
Machine learning programmes will learn patterns that might not be picked up by other types of programmes. This can be useful for problems involving complex information, such as those in the medical domain.
What has the research found?
Our first research paper, published on Nature Medicine's website on Monday 13 August 2018, demonstrated a significant step towards our goal of creating technology which would allow eye health professionals to prioritise patients with the most serious eye conditions and treat them before lasting damage occurs.
Firstly,we have developed AI technology which can match the accuracy of expert ophthalmologists and optometrists when identifying a range of eye conditions – such as age-related macular degeneration and diabetic eye disease – and generating
the correct referral recommendation.
Secondly, the research used de-identified OCT scans taken from routine care and benchmarked against real de-identified referral decisions used at Moorfields Eye Hospital, demonstrating that the AI technology is applicable to real-world healthcare settings.
The AI technology can also provide information that explains to eye health professionals how it arrived at its decisions. We think this is critically important for clinical application, since it will allow doctors, nurses and healthcare professionals to scrutinise these recommendations.
The research also demonstrated that the AI technology can be easily applied to different types of eye scanner, massively increasing the number of people across the world that it could benefit, and future-proofing the technology against new devices and models that could emerge in the future.
It's still early days, but we believe AI could revolutionise the way eye diseases are diagnosed, treated and managed, creating a system which enables eye care professionals to quickly prioritise patients with the most serious eye diseases before irreversible damage sets in – taking us one step closer to preventing avoidable sight loss.
What eye diseases can the AI system detect?
The AI system was able to detect many forms of macular disease. Age-related macular degeneration (AMD) is the most common macular condition that the AI system is able to detect. Other macular conditions include myopic maculopathy, macular holes, diabetic macular oedema and retinal vein occlusion.
However, unlike previous studies in this area, we didn't focus on or exclude any specific eye conditions for this research because we want to create technology that can identify all patients in urgent need of eye treatment, regardless of the specific eye diseases they might have.
I have age-related macular degeneration (AMD). Can the AI system help me?
The AI system is not a treatment for eye conditions like age-related macular degeneration (AMD). It is designed to detect many forms of eye disease so that it can help doctors and eye health professionals decide what care a patient might need.
There are two types of AMD: 'wet' and 'dry'.
Dry AMD is the most common type of macular degeneration and affects about four in every five people who have the condition. Unfortunately, there is no treatment for dry AMD.
Wet AMD can develop very suddenly and causes serious changes to your central vision. The treatment available on the NHS for wet AMD is with a group of medications called anti-vascular endothelial growth factor (anti-VEGF) drugs. These are injected inside your eye.
If you notice a sudden change in your vision, you should have your eyes examined by an eye health professional as soon as you can.
Where can I get more information about macular disease?
If you or a family member have been diagnosed with macular disease, help and support is available from charities including Macular Society and RNIB. They can answer questions and provide information and advice about any aspect of living with sight loss.
What are the next steps for this research?
It's still early days and this technology will need to go through rigorous clinical trials before it could be deployed at Moorfields and in other clinical settings, but we're excited about the potential it has demonstrated.
Can patients register their interest to take part in future clinical trials?
No. It is not possible to register your interest to take part in future trials due to the strict recruitment criteria.
At the time a study is recruiting, patients who have been referred to Moorfields as a patient and match against the strict recruitment criteria will be contacted by the care team to ask if they are interested in taking part.
You can always ask your GP or hospital consultant about any clinical trials or other well designed studies that you may be suitable or eligible for. The NHS also provides further information on participating in research and where to find out about active clinical studies: https://www.nhs.uk/conditions/clinical-trials.
How long will the project last?
The research project agreement is for five years.
How much data has been shared with DeepMind?
Over the course of the research project, Moorfields Eye Hospital will share approximately one million de-personalised digital eye scans, used by eye health professionals to detect and diagnose eye conditions.
Anonymous clinical diagnoses, information on the treatment of eye diseases, the model of the machine used to acquire the images and demographic information on age (shown to be associated with eye disease) will also be shared during the course of the project.
What will happen to the data now?
This is only the first phase of a five year research collaboration. At the end of the research work, the data held on DeepMind drives will be destroyed with 8-pass overwrite and a certificate of destruction will be provided to Moorfields.
Do patients have to give their consent for their data to be used?
When research is conducted using de-personalised data, with no way for researchers to identify individual patients, explicit consent from patients for use of their data is not required. For more information, please refer to the ICO Guide to the General Data Protection Regulation (GDPR).
As with all research collaboration agreements with non-NHS organisations, patients can opt out of any data-sharing system by emailing the trust's data protection officer firstname.lastname@example.com. Patients will need to include their NHS or medical records number in any messages. Opting out of research applies to all research projects at Moorfields, not just the DeepMind collaboration.
If you don't want your confidential patient information to be used for research and planning, you can opt out of this. If you do opt out, there are some specific situations where your data may still be used. Data that does not identify you may still also be used.
In this case, all future research will take place excluding those who have opted out. As with all studies on anonymised datasets, measures will be adopted to render it impossible to identify any individual patients. It is therefore not possible to opt-out of research already underway for this reason.
What are the data protection measures in place for this project?
We rigorously ensure that no personally identifiable data is included in the database of scans which is provided to DeepMind for this project.
During the course of the project DeepMind is taking rigorous measures to protect the security of the data, and avoiding disclosing it to anyone other than the researchers and engineers working on the project.
Data contributing to this study can only be used for research that explores the use of machine learning to support clinicians in their management and diagnosis of eye diseases. The data itself cannot be linked with any other dataset, although any new models or software produced by the research may be linked to other datasets to allow for it to be used to help treat patients in the future, and also to enable further research to improve the models by drawing upon other approved sources of data.
How can patients be sure that no identifiable data is being shared with DeepMind?
Anonymisation procedures are thoroughly validated and formally approved by the Moorfields Eye Hospital information governance team before any data transfer to DeepMind takes place.
What processes are in place to ensure the data transferred to DeepMind is only ever seen by the research team?
A data custodian has been appointed by DeepMind to control access to the data. Only those who require access to conduct the research work will be granted access. All researchers who are involved in the study are required to complete Health and Social Care Information Centre (HSCIC) and internal DeepMind information governance training before beginning research work.
What approvals has DeepMind been given for this research project?
DeepMind has been given permission for data access via a Research Collaboration Agreement with Moorfields Eye Hospital, and an approval to carry out research from the Moorfields Research & Development department through their Research On Anonymised Data (ROAD) approval pathway.


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This article shows how to control game events by script commands. This includes how to make an event move around (applying a move route), change their graphic and so on.
Simple script commands
The script section PokemonField contains several functions for controlling events with scripts. For an example of their use, see the script section PokemonDuel.
Waits for x frames, where one frame is 1/40 of a second. While waiting, processes the rest of the scene.
Shakes the screen with a given power and speed for x frames, where one frame is 1/20 of a second. Returns immediately, so that other things can be made to happen during the shaking.
Flashes the screen with a given colour for x frames, where one frame is 1/20 of a second.
Sets the color tone for the screen and all graphics thereon. Fades the tone in for duration frames, where one frame is 1/20 of a second.
Runs a move route on an event (Game_Character). To set the player's move route, use
$game_player for event. To set the move route for an event on the current map, use
$game_map.events[X], where X is the event's ID. event can be nil. commands is an array of move route commands, with each command followed by a set of parameters for that command. Here is an example of a move route defined for a player:
pbMoveRoute($game_player,[ PBMoveRoute::ChangeSpeed,2, PBMoveRoute::Backward ])
Notice that the ChangeSpeed command is followed by a number specifying the speed. The Backward command has no parameters. Here is a list of possible commands, together with their required parameters:
- Down, Left, Right, Up - no parameters
- LowerLeft, LowerRight, UpperLeft, UpperRight - no parameters
- Random - no parameters
- TowardPlayer, AwayFromPlayer - no parameters
- Forward, Backward - no parameters
- TurnDown, TurnLeft, TurnRight, TurnUp - no parameters
- TurnRight90, TurnLeft90, Turn180, TurnRightOrLeft90 - no parameters
- TurnRandom, TurnTowardPlayer, TurnAwayFromPlayer - no parameters
- WalkAnimeOn, WalkAnimeOff - no parameters
- StepAnimeOn, StepAnimeOff - no parameters
- DirectionFixOn, DirectionFixOff - no parameters
- ThroughOn, ThroughOff - no parameters
- AlwaysOnTopOn, AlwaysOnTopOff - no parameters
- Jump - X offset; Y offset
- Wait - Number of frames to wait (1/20 second)
- SwitchOn - Switch number
- SwitchOff - Switch number
- ChangeSpeed - Desired movement speed (1-6)
- ChangeFreq - Desired frequency (1-6)
- Graphic - Filename; hue (0-359); direction (2=up, 4=left, 6=right, 8=up); pattern (0-3)
- Opacity - New opacity (0-255)
- Blending - New blend type (0=normal, 1=add, 2=subtract)
- PlaySE - Name of the sound effect (SE) file to play
- Script - Script to run
- ScriptAsync - Script to run (the move route doesn't wait for its completion before continuing)
When using "pbMoveRoute", it will always set ThroughOn at the beginning and ThroughOff at the end. This means the event can be made to move to places it wouldn't ordinarily be allowed to go (e.g. the player walking on water, an NPC moving over a tree). Be sure that nothing strange can happen because of this.
This function returns immediately, and doesn't wait for the move route to complete. This function's return value is the generated move route (RPG::MoveRoute).


text: Successful people do things unsuccessful people don't like to do. Comfort is highly overrated in the short run, and often underrated in the long run. In the short run discomfort is a sign that something is happening. It's usually growth of some kind, or at least something that will lead to growth. Bask in that. Use it. Get better. It's not permanent. However, when the dull nauseating angst drags on it's a sign that more short-term discomfort may be required to move things off center. This means change.


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Highlights in the History of Whaling
Rosemead, CA: Bookhaven Press, 1968. Number 381 of 500 copies. This lovely miniature book was the second book to be printed at Pall Bohne's Bookhaven Press. As he states in the colophon, Bohne was the author as well as the illustrator, typographer, printer, and binder. "Pall W. Bohne (1935-2017) was an eminent member of the Southern California fine press and book arts scene who was known particularly for his expertise in letter press printing. As the operator of Bookhaven Press in Rosemead, California from 1967-1992, Bohne produced numerous works of ephemera and printed pamphlets, including a few miniature books, including Highlights in the History of American Whaling and Jabberwocky, the Famous Mock Heroic Epic. Bohne demonstrated his skills as an artisan through wood-engraving and bookplate production, and purportedly held a wide range interests in other fields such as beekeeping and blacksmithing" (from UCLA library finding aid for their Bohne collection). Bound in grey paper covers with black glossy paper spine with title in gilt. Small nick and repair to top of spine. otherwise very good. Interior pages near fine with many illustrations by Bohne of whale species, whaling tools, and products made from whales such as scrimshaw and corsets. 45 pages including bibliography. Measures 1 7/8 x 2 1/2 inches. MINIATURE/111418.
Item #32576
Price: $75.00


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'She's a woman who has been pursued in the same way that Diana was' – George Clooney defends friend Meghan Markle
George Clooney has made it clear he's Team Meghan Markle.
In less than one year, Britain's Duchess of Sussex has attracted ire of royal watchers not seen before the social media age and since a rumoured rift with sister-in-law Kate Middleton was made public last year, the interest into her private life has been unwavering. None of this has been helped by the fact that her father Thomas regularly sells stories about his daughter and most recently on Sunday, released a private handwritten letter in which she begged with him to stop dealing with the press and to allow her to live her life.
When asked about the ongoing treatment of the former Suits star, which is playing out in front of the world's media, Clooney, who attended Meghan's wedding to Prince Harry last May with wife Amal, said: "They're just chasing Meghan Markle everywhere, she's been pursued and vilified. She's a woman who is seven months pregnant and she has been pursued and vilified and chased in the same way that Diana was and it's history repeating itself."
"We've seen how that ends," he told Australia's Who magazine.
It's reported that the Clooneys, who have a home in the UK, have become increasingly close with the Sussexes, enjoying cosy nights at their home in the Cotswolds and while he wouldn't be drawn about the status of his friendship, he laughed off any suggestions he's in the running to become godfather.
"Oh yes, I'll be godfather of the royals apparently," he said, before adding, "No! I'm a father of twins, I have enough s**t to deal with – literally."
Fresh criticism against the new duchess appears to have come from a piece in People magazine in which a number of her closest friends, who jumped to her defence, albeit off the record, with such detail that it's believed the expectant mother approved her friends to break their silence. The magazine's cover story detailed five different friends who wanted to "stand up against the global bullying we are seeing and speak the truth about our friend" and detailed how "normal" Meghan still is and remains in touch with her nearest and dearest from her pre-royal life.
"Meg has silently sat back and endured the lies and untruths. We worry about what this is doing to her and the baby. It's wrong to put anyone under this level of emotional trauma, let alone when they're pregnant," a source said.
Another friend added they had stayed at Nottingham Cottage, the two-bedroom property where the couple lives on the grounds of Kensington Palace, saying: "We had a couple of days together recently. Her husband was out of town on work. In the room she made up for me, there was a candle lit by the bed, slippers and a robe. We were the only two in the house. It was our time.
"She made the most lovely meals. She made tea every day. It was raining and muddy outside, so the dogs got all dirty, and she's wiping them off with towels. How much she loves her animals, how much she loves her friends, how much she loves feeding you, taking care of you — none of that has changed."
The wave of abuse has been so prominent against Meghan and Kate in recent months that Kensington Palace is battling to monitor it all.
"The Palace has always monitored comments but it's a hugely time consuming thing. They can block certain words, but some of it is quite serious," a source told Hello! last month. "Over the course of last year, with hundreds of thousands of comments, there were two or three that were violent threats. You can delete and report and block people and the police have options around particular people. It's something you have to manage because there's no other way to control it."
Source: Read Full Article


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Women Hold Fewer Than a Quarter of LA's Cannabis Licenses
Women-owned businesses make up roughly 13% of licensed retailers and distributors in LA, according to a Leafly analysis. Another 12% are co-owned by women.
Iowa AG Tells Agency to Halt Portion of Medical Marijuana Law
An unusual attempt by Iowa to work with another state to transport medical marijuana oil across state lines is on hold amid legal concerns it could invite scrutiny from the federal government.
Nevada Tax Panel Makes Key Decision on Transporting Cannabis
The state Tax Commission voted unanimously to uphold an earlier decision to expand licensing to those other than liquor distributors because they have been unable to keep up with demand.
Ohio Picks 2 Vendors to Ramp up Medical Marijuana System
A pair of vendors has been selected to develop Ohio's seed-to-sale, medical marijuana tracking system and its online licensing system.
Nevada Judge Clears Way for More Cannabis Licenses
A Nevada judge has cleared the way for the state's marijuana regulators to start issuing cannabis distribution licenses to businesses other than existing alcohol wholesalers.
Arkansas Has Received Zero Applications to Grow or Dispense Medical Cannabis
Arkansas Department of Finance and Administration spokesman Scott Hardin said Friday morning that the agency had received no applications to grow and distribute medical marijuana.
Heavy Interest in North Dakota Medical Marijuana Network
"I'm pretty sure we're going to have the ability to have a dispensary in each part of the state," said the director of the Health Department's medical marijuana division.
Some Nevada Cannabis Retailers 'Running on Fumes'
Most of Nevada's cannabis retailers are optimistic an emergency regulation will help keep them from running out of product, but some are "running on fumes."
Nevada Officials to Consider Emergency Rule on Cannabis Distribution
"We are now informed that many [dispensaries] have only days or weeks of product to be sold," says the chief of staff for Gov. Brian Sandoval.
Nevada Cannabis Ruling May Delay July 1 Start Date
A judge in Carson City ruled that the state hasn't followed the rules of its legalization initiative. Stores open July 1? Maybe not.
Massachusetts Tobacco Wholesalers Want a Piece of the Cannabis Pie
The tobacco industry in Massachusetts is trying to get a piece of what's expected to be a lucrative state cannabis market.
California Cannabis Farmers Insist on Driving Their Own Trucks; Here's Why
Craft cannabis companies say distribution control is critical to their success. The Teamsters disagree.
'Security Cows' Will Guard This Hawaiian Cannabis Farm
Farmer Richard Ha is going beyond the security measures mandated by the state. He's hired cows. Security cows.


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What dates are you thinking of traveling? It only takes one click to check our availability calendar, so, what are you waiting for??
If you're on a budget, our one-bedroom condo in Playas del Coco is affordable while offering ocean views. You can save money while you're visiting by shopping at one of the modern-style, local grocery stores and preparing your meals in our kitchen, which features Costa Rican hardwood cabinets and granite countertops.
Check our reviews on tripadvisor!
Staying at our quiet condo complex also ensures a relaxing vacation where you can enjoy the ocean views from our bedroom balcony or our rooftop terrace. Our condo offers the added bonus of being fully air-conditioned, plus we offer free Wi-Fi and we're only 7 steps from the pool!!
Questions? Send us an email and we'll be glad to help you make your dream of traveling to Costa Rica come true.
And remember, during Green Season (April to October) in Costa Rica, it's the time to save big on our condo, with rates as low as USD $25 per night!!
Seriously?? Yes!! It's your turn to finally visit Costa Rica!!
Ed & Connie


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5 Things Women in Recovery Should Be Doing!September 30, 2015 - Addiction, Recovery, Women's Treatment - 0 Comments
Recovery can be a very hard time for a woman. You have taken all of the right steps and completed all of the grueling treatment to find that recovery is just as hard. Do not worry, you are not at all alone.
Here are five things that women should be doing while in recovery:
1. Pick up a hobby
Have you always wanted to learn how to sew, cook, or play sports? Your previous addiction may have made it seemingly impossible to learn these tasks. Now you are in recovery and have the time and the energy to engage in all of the wonderful things you had to miss out on before. As an added bonus, you get to spend quality time with loved ones, learn new things, and have something awesome to talk about in your next meeting with friends. Plus, with this new hobby you'll be too busy and too happy to even think about your old addiction!
2. Stop holding on to regret
We know it's hard, but we also know you can do it. All of the of the good and bad things that have happened in the past have shaped who you are and what you want to become. Your choice to become a healthier, stronger, happier woman is a great decision. You are an inspiration to those who want to quit their addiction. You are a clear-thinking individual who can love your family to the fullest extent. And you are a beautiful individual realizing that willpower is in fact enough. You set examples for young women and teenage girls that they can say "enough is enough" or that they don't have to live the life they have always lived if it was ruled by addiction. You should never feel regret for making a good decision.
3. Adopt a pet
You don't have to run out and adopt a dog, maybe a flower or plant would also suit you well. Adopt something new in your life to celebrate this new chapter. Make sure that whatever you adopt, you love it and would be willing to take care of it. This new adoption is both symbolic of a happy beginning and a commitment to a happier life filled with love and smiles. You deserve this.
4. Write down all of the things that you are happy to have accomplished now that you are in recovery
Write each of these things down on a small strip of paper, fold it up, and put it into a large jar or box. On bad days pull one of these strips of paper out and remind yourself that this is just one bad day and that you have good things and good memories in your life.
5. Smile
Smile as much as you can. You have done something so hard that other people just cannot fathom doing it. Be inspirational, supportive, and smiley to those around you. Smiles are contagious and you will find that the more often you smile, the more often others smile around you. Being happy and wanting to make others happy is such a beautiful thing!
Comments are closed here.


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Through the power of Front Desk, Propertybase is able to capture leads from contact forms. There are several different methods Propertybase uses to accomplishes this. In this article we will review, in detail, how to configure one of those methods: XML-to-Email.
Note: Before you can use XML-to-Email, you must enable Front Desk.
XML-to-Email Overview
The concept of XML-to-Email webforms is very simple. Your web form captures data from potential leads and sends that data in a specific XML format to your unique Front Desk email address. It's very important the data being sent to Front Desk follows the specified XML format. The code below shows all supported XML tags for both Contact and Inquiry objects. Please note that XML tags are case sensitive.
Supported Contact Fields
<FirstName>Form Data</FirstName> <LastName>Form Data</LastName> <Email>Form Data</Email> <Phone>Form Data</Phone> <LeadSource>Form Data</LeadSource> <MailingStreet>Form Data</MailingStreet> <MailingCity>Form Data</MailingCity> <MailingPostalCode>Form Data</MailingPostalCode>
Supported Inquiry Fields
<Project_Name__c>Form Data</Project_Name__c> <pbasr__Rotation_Name__c>Form Data</pbasr__Rotation_Name__c> <Property_Enquired_About__c>Form Data</Property_Enquired_About__c> <Enquiry_URL__c>Form Data</Enquiry_URL__c> <How_did_you_hear_about_us__c>Form Data</How_did_you_hear_about_us__c> <Enquiry_Source__c>Form Data</Enquiry_Source__c> <Message>Form Data</Message>
Note: Not all XML tags are required, only Last Name. This is how Propertybase assigns leads to specific Contact records.
Custom Fields
You can use custom fields, but you must include the exact API name of the field you would like to use. Our support team will need to verify that we have setup the correct mapping in the backend. After you send in test record if something does not go in correctly, let us know and we will adjust your mapping. Always make sure you Grant Access, so we can verify.
Frequently Asked Questions
What if I can't send my emails using XML?
Although XML is the preferred format, you can send lead emails using any format to Front Desk. Please note that if you send emails to Font Desk using a format other than XML, it make take up to 48 hours for our Support Team to develop a parser to accept your leads.
Does the fields have to be in a specific order?
No it does not matter, Inquiry and Contact fields can be mixed up. As the system will know where to start and stop grabbing the information for each field. Start grabbing last name at <LastName> and end at </LastName>


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When the ego warrior is originally born within our lives, it is vulnerable and pure like a child. Through life experiences, the pure ego adapts into it's nature. For an example, if a person was bullied, beat up or looked down upon in society, the ego will develop a safety mechanism from that experience. The safety mechanism is usually manifested via a person's believe system. Therefore, a person can believe that they must act, be, or not trust certain people for protection. Just as the ego can create a belief system that they are not worthy of certain luxuries in life. These different types of belief systems can be applied to any positive and negative experiences in our lives. It is important to realize that the belief system manifested from our ego is not good or bad. It is merely a reflection of a person's perception of how they feel they should adapt and protect themselves from others.
The ego warrior can become dangerous, however, when it is creating/protecting and reacting from the emotion of fear. Fear is the emotions that can make the ego become over protective of itself. Therefore, the ego can becomes very selfish and feel separated from others. This is when the 'Me verses them' mentality manifests into reality. In this sense, it becomes very arrogant and cocky and ready and willing to attack anyone who it feels is a threat to their identify or personality while not taking responsibility for their actions. Yes, the ego seems very confident in this state, but it is only a disguise to hide the internal wounds.
But it is never too late for healing. We can overcome and heal our ego, with time of solitude, isolation and admitting to our self that we are not perfect. Because it is YOU who truly knows the pains of your life and your manifested belief systems. Only through analyzing, reflecting, learning, and observing yourself can we learn to heal ourselves. Looking within may not be easy, however, because this pushes us to be honest with ourselves and to face our fears . But the only way to battle fear, is to battle it head on. Once you do that, you will realize it is not as bad as you think. Then you can transform your ego and your reactions if you feel the need. Once you feel that the ego warrior is more like a samurai, it will be honorable and loyal to your higher self (god/goddess) within. And in this union you will have the strength to be warrior when needed combined with spirituality at the same time. A perfect union for with you path to ascension.


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Too much to do to be wasting time with La PhotoCabine. Thanks to James of Bluebird Vintage for that little link! Luke took a million turns, and almost all of them were blurry. Timing for this kind of thing is lost on a 4 year old. If you're wondering about the room decor, our computers are appropriately situated in the official nerd den. The artwork behind me is original animated cels (fist of the north star, akira, astro boy, wicked city, golgo 13, he-man, black star). And yes, we have a 4 player arcade machine Todd built there too. It's HUGE and runs on an emulator so it plays practically every old arcade game there is. All this fabulous geekery courtesy of Todd ;-D
Back to the grind!
XO - Jill
PS. hehe. I just noticed the light makes Todd look like he's a bit shiny on top if you know what i mean. hehe. He's not - but he's going to hate me if he reads this. Sorry cutie!


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Oct 26 2018
Nipper Board and Beach Training
If you ticked 'yes' for additional board training here's what you need to know…. There are 2 squads - ADVANCED & DEVELOPMENT The ADVANCED squad is assessed by skill level & competency – not age. Members of this squad are expected to commit to both Tuesday (creek) & Thursday (surf) sessions. The squad is by(…)


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The other day I came across an interesting article singing the praises of the 6 hour work day. The argument basically states that people are far less productive when they have to wake up before the sun comes up and that people in professional and creative jobs can work at their best for only 6 hours a day.
I'm all for better working conditions, and it would be nice to only put in six hours a day, but I don't know if I buy this argument at all. I think my work quality is proportional to my motivation. If I'm working on something I'm passionate about, putting in a 13 hour day is no problem. Conversely, if I don't care about my project and I am just waiting for the hours to pass, 6 hours can seem like an eternity.
I also feel like any company that went to a six hour day would have a very good reason to pay their employees less. I'd much rather keep my 8 hour day and current salary.
Now for the best tips from the around the web on earning more money and spending less…
Andrew @ 101 Centavos writes Ten Things You Can Do To Impress People At Work – Working for the Man takes some doing. The workplace can be a political jungle, populated with hazards like vengeful Vice Presidents, ambitious underlings, and fearsome human resources trolls who are just waiting for a chance to eviscerate your career with razor-sharp talons. Fear not, here's the prototypical blog list of ten things you (yes, you!) can do to get ahead. Some of them may require effort, some not so much.
Graham @ Moneystepper writes Timing the market: can you improve gains by timing the stock market? – Timing the stock market: can you easily time the markets? I'll be brief. No. You can not. Do not try.
Alexa @ Single Moms Income writes Blog Goals Update #1: How I Tripled My Search Engine Traffic In 30 Days – Blogging is a legitimate way to earn money and one of the ways I do so. And, it is something anyone can do as long they are committed. Here is update number one on my blogging goals.
Larry @ KrantCents writes Classic Cars, Muscle Cars and Antiques Cars Are Good Investments! – Buying a used car will save you money, but a classic, muscle or antiques cars may actually make you money. You still have to choose your car carefully, but these cars usually increase in value unlike your typical car which decreases in value as soon as you buy it.
Holly @ Club Thrifty writes Buying a House: HOA Fees and Other Shenanigans – Living in a neighborhood with an HOA usually means extra rules and at least a few HOA fees. However, there are benefits to having an HOA.
Gary @ Gajizmo writes How To Find A Job After College – If you are a college student about to graduate next semester, you know that Spring and Summer offer the best opportunities to find a job after college graduation. Here are some tips on how to find a job after college.
Joshua Rodriguez @ CNA Finance writes Is It Time To Start Investing – In this post, Joshua talks about when it's the right time to start investing as well as other things that beginning investors should know.
Tonya Stumphauzer @ Budget and the Beach writes How I Made 10k in Side Income – A breakdown of how I made 10k in side income in 2013.
Pauline @ Make Money Your Way writes Making enough money for retirement – Everyone can make a little extra money, it is not that difficult. This post will give you several ideas about making enough money for retirement.
Matt Becker @ Mom and Dad Money writes Should Young Investors Really Fear a Market Downturn? – For younger investors, the fear of market downturns really needs to be challenged. In fact, the biggest risk we face is not the big market downturns, but failing to participate in the big market rallies.
Miss T. @ Prairie Eco Thrifter writes Want Better Career Success? Develop Your Confidence – If you are looking to improve your career prospects, one of the best things you can do is develop confidence.
Jacob @ Cash Cow Couple writes Low Cost Cell Phone Plans – We've been researching the cheapest cell phone plans available. Come check them out and save a boatload of money on your monthly bill!
Dee @ Color Me Frugal writes 12 Free or Cheap Ways to Get Exercise in the Winter – Here are 12 frugal and fun ways to make sure you stay active when the weather turns cold!
Kay @ Green Money Stream writes How I Overcame the Lure of Lifestyle Inflation – It's easy to get caught up in the chase of lifestyle inflation, especially as you start to earn more money in your 30's. Here's how lifestyle inflation began to take hold on me and how I was able to resist its lure.
The Warrior @ Net Worth Warrior writes The Ultimate Guide to (Finally) Cutting the Cable or Satellite Cord – In-depth review of how to make the transition from cable or satellite to other resources of television entertainment.
Adam @ The Cheapest Cars To Insure writes 10 of the Best Insurance Group 1 Cars – Getting the best affordable insurance policy for your type of car.
Jack @ eMoneyLog writes A guide to shopping from thrift stores – Shopping at a thrift store can be difficult if you do not know what to buy at these stores. It can actually be very intimidating. Some of the items are just crap, many are average quality but you can also often find gems if you know what to look for. In this post I take a look at the best items to buy from the ones available at a thrift store. There are many stores that will carry old items that have antique value. If you know how to identify these you an end up with some really good items at
Jay @ The First Million is the Hardest writes Early Upgrade Plans – What Your Wireless Company Doesn't Want You To Know – Plans that allow you to upgrade your phone after 6 months are all the rage right now. Are they a good deal, or are they another way for your wireless company to make more money off of you?
Justin @ Root of Good writes I Have a Luck Making Machine – Find out how the Luck Making Machine makes us wealthier and always makes smart choices. From houses to cars to careers, we always seem to have the best luck thanks to the Luck Making Machine we own.
Irfan @ Everything About Investment writes Tips for Personal Financial Success – Getting a handle of managing your basic personal finance can return many financial rewards as well as provide you with more free time to pursue your interests and freed up money to invest. When we talk about the basic elements of anyone's personal finances we are including a personal budget, savings and investment planning, managing your income and outgoings resourcefully as well as applying for loans and finance and various insurance policies you may need over your lifespan.
John @ Frugal Rules writes And You Wonder Why We Have Financial Problems… – Recent studies show, and not really surprisingly, that much more money is being spent to market financial products as opposed to teaching about them. While this may seem like an impossible problem to solve, teaching financial literacy can help stem the tide. Teaching financial literacy will help individuals begin to make wiser financial decisions like saving for retirement and living within their means.
Lazy Man @ Lazy Man and Money writes 5 Smart Shopping Apps for this Holiday Season – As you prepare for the holiday shopping season, here are 5 apps that can help you save money:
Grayson @ Debt Roundup writes How I Saved $780 Per Year On My Cell Phone Bill – One question that I get often is "How do I save money on my cell phone bill?". I can understand the popularity of this question because it seems cell phone bills are getting higher and higher these days. I decided to show others how I saved $780 per year on my cell phone bill.
Richard Adams @ Frugality Magazine writes Buy Books Cheap: How To Save 24% When Buying Books Online – If you're an obsessive reader like me, yet hate to spend unnecessary money, it makes perfect sense to try and buy books cheap. Fortunately – as you're about to see – there is a simple yet effective way to buy books cheaply online and save a surprising amount of money on what you would have spent shopping elsewhere.
Lisa E. @ Lisa Vs. The Loans writes Use Your Personal Network to Save Major $$$ on Your Wedding – It's no secret wedding are expensive. But with some creativity and a lot of help, you can achieve the wedding of your dreams regardless of your budget!
Little House @ Little House in the Valley writes DIY Holiday Gifts: Cookie Exchange – This year, I've been invited to a cookie exchange. Basically, I bake one type of cookie, bring a huge amount (because we'll be taste testing and swapping), then package them up as gifts. I'll leave the event with about 60 different types of cookies packaged into a handful of gifts. It will be another great way to give gifts to colleagues and friends without spending a ton of money.
KK @ Student Debt Survivor writes Are Community-Supported Agriculture Shares a Good Deal? – CSA shares are a healthy way to get your day's worth of fruits and veggies, but do they save you money?


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Sole Proprietorship
Sole proprietorship refers to the individual ownership of a business. Here one individual is at the helm taking all the important policy decisions. There is a single chain of command. Also, the responsibility to pay taxes rests on the sole owner's shoulders. Let us discuss sole proprietorship in detail.
Advantages & Disadvantages of Sole Proprietorship
A sole proprietorship signifies the simplest form of business that can be owned in Canada. A single owner has all the reigns under his command in this form of business. Under the Canadian law, the owner and the business are considered one single entity. So, these two entities are viewed as one in the eyes of the law and proceedings are carried out accordingly. Secondly, the owner owns all the assets and resources of the business. Most importantly, the sole proprietor cannot claim employee status under his/her own business. He shall not receive a salary from the business. Instead, he can earn a profit from the business operations. So, the owner cannot be the employee in case of sole proprietorship.
Now let us discuss the advantages and disadvantages in case of sole proprietorship.


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New Title & A Cover
I'm hoping the work comes ready for print release around August 1, with an eBook release around and about August 11 to 17th. We'll see how it all fares as it goes through the editorial process with Marva Dasef.
The cover is coming final, too, though it will go through some adjustments and changes, I'm sure, before we're all happy. Here's the working final:


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Yael T. Abouhalkah
Johnson County's GOP primaries turn white-hot as Wednesday event looms
Johnson County Republican voters hold the fate of the Kansas Legislature in their hands as Aug. 2 elections loom.
A little bit of hyperbole there? Perhaps, but the case certainly can be made.
The county's moderate GOP voters have plenty of chances to kick out the extremist legislators who have helped Gov. Sam Brownback destroy the state's finances.
One way to do that is tie the ultra-conservatives to their support over the years for the reckless steps Brownback has taken, with the lowlight being the income tax cuts that have slashed $650 million a year from the state budget. That money could have been used for public services such as solid schools and universities.
But Brownback and his proponents such as the Kansas Chamber of Commerce are fighting back. This week the chamber's PAC released its list of endorsements, with lots of Brownback sycophants on the page.
In addition, incumbents are lashing out against their opponents, supporters or the press (imagine that!) on social media, such as Sen. Jeff Melcher has decided to do.
So who are the good guys and gals in many of these races?
Johnson Countians can see for themselves at a League of Women Voters of Johnson County event from 7 to 9 p.m. Wednesday at the Blue Valley CAPS Building, 7501 W. 149th Terr., in Overland Park.
The league says it has invited all candidates in competitive House races in a large portion of Johnson County, as well as the Senate district in that area.
Here's the unknown: Will the ultra-cons show up to make their case that they deserve to be retained in office? Or will they cede the two hours to their challengers?
That's what happened Sunday. I attended another league event in northeast Johnson County where none of the incumbents showed up to defend their records. But most of the challengers appeared.
For example, Dinah Sykes made a good case that she's ready to provide better leadership for the Republican Party in Senate District 21 than incumbent Greg Smith has done in recent years. Smith failed to show.
Here's the lineup for Wednesday's event, per the league. I have boldfaced the candidates who — up to this point — appear to be more promising candidates in the races. An asterisk notes an incumbent.
District 8: Patty Markley, Craig McPherson*
District 14: Keith Esau*, Leesa Gabel
District 15: Erin L. Davis*, Bo Dostal, Kim Palcic
District 20: Rob Bruchman*, Jan H. Kessinger
District 27: Timothy James Harmon, Sean E.Tarwater, Sr.
District 28: Joy Koesten, Jerry Lunn*
District 30: James A. Dingwerth, Randy Powell*
District 38: Willie Dove*, Nathan Lucas, Mitra Templin
District 43: Donald Roberts, Bill Sutton*
District 78: Allen Clayton, Ron Ryckman*
District 11: Jeff Melcher*, John Skubal
Yael T. Abouhalkah: 816-234-4887, email@example.com, @YaelTAbouhalkah


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Pope essay on criticism analysis
St. Anne Byzantine Catholic Church
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Church - (727) 849-1190
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In Memory of +Father Basil
The Divine Liturgy Schedule
The Divine Liturgy
Our Online Prayer Book
Parish Photo Gallery
Links to Other Byzantine Pages
Fasting and abstinence
Visit Our Iconostasis!
Tropars for the Saints of the Calendar
The Divine Liturgy Schedule
Sundays: 10:00 A.M.
Holy Days: 10:00 A.M.
Weekdays: 10:00 A.M.
For a detailed schedule, click .
Please try the
New Calendar and provide your feedback!
Please click above for special dates and times
Hall rentals can be made by contacting Anne-Marie at 847-2310.
Many thanks and many years to Christina
Brundage for previously maintaining this website!
Saturday, 10. July 2004 23:56 -0400


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join e-list
Learn how refugees have escaped persecution to come to the crossroads of the U.S in this interactive event that includes an exhibition highlighting post-WWII resettlement efforts, information fair, reception, and panel discussion.
Extended hours and free admission to the Eugene and Marilyn Glick History Center will allow attendees to view You Are There 1950: Making a Jewish Home, an exhibit that tells the story of the Kaplans, a family which fled the Holocaust and made a new home in Indianapolis. This story, other historical stories, and contemporary stories of resettlement in Indiana will be featured in this event which explores why people leave their homes and how service organizations work to ease the burden of that transition. Additionally, attendees will learn how they can become part of the effort to make a difference in their community.
Presented by Indiana Historical Society and Jewish Federation of Greater Indianapolis. Questions? Call 317-233-1882 or email email@example.com.
MapPhoto credit: Indiana Historical Society
Spirit & Place is a project of the Polis Center, IU School of Liberal Arts/IUPUI


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We crowdsource Edible Arrangements's maternity, paternity and parental leave policies, based on Edible Arrangements's employee reviews and anonymous tips from Edible Arrangements employees.
Edible Arrangements Maternity and Paternity Leave Policies
Edible Arrangements offers. This information is based on anonymous tips submitted by employees.
Retail: Other Maternity and Paternity Leave
How many weeks of paid maternity, unpaid maternity, paid paternity and unpaid paternity leave do employers in the Retail: Other industry offer?


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Halloween Celebration main content.
Halloween Celebration
Saturday, October 27, 2018
Saturday, October 27, 2018
Curious George®, Clifford the Big Red Dog®, Franny K. Stein, Little Critters®, and Miffy are among the characters who will greet costumed children as they arrive at the American Museum of Natural History to celebrate Halloween.
With more than 30 Museum halls open for the event, guests are invited to wander among "ferocious" dinosaurs, "eerie" elephants, and the "mysterious" universe for trick-or-treating, arts and crafts, and fun with roaming cartoon characters, stilt-walkers, and balloon artists.
There will also be live performances and presentations by:
Made possible with the support of The Rudin Foundation, Inc.


text: This family is so unique and fun. These three sisters are typical sisters. Best friends one minute, enemies the next. We visited one of their favorite picnic spots by the lake with the sweetest little canal each girl took turns sitting on the dock overlooking. Evelyn is getting so big, but the girls had fun chasing her around and snuggly up for a few pics together. Thanks so much to this awesome family!