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EMESSA Labs for Pharmaceutical Industries was
established in 1958
as one of the most deep-rooted pharmaceutical factories
in Syria
By Pharmaceutical
Pharmacologic Category
Each F.C. tablet of Carvedilol 12.5 contains: Carvedilol 12.5 mg
A pack containing 20 F.C. tablets of Carvedilol 12.5
105 sp
89 sp
Carvedilol is nonselective (beta) adrenergic blocking agent with (alpha)1-blocking activity.
Mechanism of action:
As a racemic mixture, carvedilol has nonselective beta-adrenoreceptor and alpha-adrenergic blocking activity at equal potency. No intrinsic sympathomimetic activity has been documented. Associated effects include reduction of cardiac output, exercise- or beta agonist-induced tachycardia, reduction of reflex orthostatic tachycardia, vasodilation, decreased peripheral vascular resistance (especially in standing position ), decreased renal vascular.
Resistance, reduced plasma renin activity, and increased levels of atrial natriuretic peptide.
Absorption/Distribution: Carvedilol is rapidly and extensively absorbed following oral administration, which absolute bioavailability of 25 to 35 %
Due to a significant degree of first-pass metabolism. Following oral administration, the apparent mean terminal elimination half-life generally ranges from 7 to 10 hours. Plasma concentrations achieved are proportional to the oral dose administered.
Carvedilol is >98% bound to plasma proteins (primarily albumin).
It has a steady –state volume of distribution of 115 L, indicating substantial distribution into extravascular tissues. Plasma clearance ranges from 500 to 700 ml/min.
Metabolism/Excretion: Carvedilol is extensively metabolized.
Less than 2% of the dose was excreted unchanged in the urine. The metabolites of Carvedilol are excreted primarily via the bile into the feces.
Congestive Heart Failure:
Carvilol is indicated for the treatment of mild or
Moderate (NYHA class II or III) heart failure of ischemic or car-diomyopathic
Origin, in conjunction with digitalis, diuretics, and ACE inhibitor, to reduce the progression of disease as evidenced by cardiovascular death, cardiovascular hospitalization, or the need to adjust other heart failure medication.
Carvilol may be used in patients unable to tolerate an ACE inhibitor. Carvilol may be used in patients who are or are not receiving digitalis, hydralazine or nitrate therapy.
Hypertension: Carvilol (Carvedilol) is also indicated for the management of essential hypertension. It can be used alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.
Carvilol is contraindicated in patients with NYHA class IV decompensated cardiac failure requiring intravenous inotropic therapy, bronchial asthma or related bronchospastic conditions, second - or third - degree AV block, sick sinus syndrome (unless a permanent pacemaker is in place), cardiogenic shock or severe bradycardia.
Use of Carvilol in patients with clinically manifest hepatic impairment is not recommended.
Carvilol is contraindicated in patients with hypersensitivity to the drug.
1- Cardiovascular: Bradycardia, postural hypotension, edema.
2- Central nervous system: Dizziness, somnolence, insomnia, fatigue.
3- Gastrointestinal: Diarrhea, abdominal pain.
4- Neuromuscular and skeletal: Back pain.
1- Respiratory: Rhinitis, pharyngitis, dyspnea.
2- Other adverse reactions occurring in less than 1%:
- V block, extrasystoles, hypertension, hypotension, palpitation, peripheral ischemia, syncope, ataxia, vertigo, depression, nervousness, malaise, pruritus, rash, decreased male libido, hypercholesterolemia, hyperglycemia, hyperuricemia, constipation, flatulence, xerostomia, impotence, anemia, leukopenia, hyperbilirubinemia, paresthesia, myalgia, weakness, abnormal vision, tinnitus, asthma, cough, diaphoresis.
Use with caution in patients with cobgestive heart failure treated with digitalis, diuretics, or ACE inhibitor since A-V
conduction may be slowed:
discontinue therapy if any evidence of liver injury occurs; use caution in patients with peripheral vascular disease, those undergoing anesthesia, in hyperthyroidism and diabetes mellitus.
If no other antihypertensive is tolerated, very small doses may be cautiously used inpatients with bronchospastic disease. Abrupt with drawal of the drug should be avoided, drug should be discontinued over 1-2 weeks:
do not use in pregnant or nursing woman; may poteniate hypoglycemia in a diabetic patient and mask signs and symptoms; safety and efficacy in children have not been established.
Decreased effect: Rifampin may reduce the plasma concentration of carvedilol by up to 70%; decreased effect has also occurred with aluminum salts, barbiturates, calcium salts, cholestyramine, colestipol, NSAIDs, penicillins (ampicillin), salicylates, and sulfinpyrazone due to decreased bioavailability and plasma levels; beta-blockers may decrease the effect of sulfonylureas.
Increased effects: Carvedilol may enhance the action of antidiabetic agents, calcium channel blockers, digoxin; clonidine and carvedilol may result in augmented blood pressure and heart rate lowering effects. Other drugs likely to increase carvedilol's levels and effects include quinidine, fluoxetine, paroxetine, and propafenone since these drugs inhibit CYP2D6.
Increased effect/toxicity of other beta-blockers occurs with contraceptives flecainide, epinephrine (initial hypertensive episode followed by bradycardia), lidocaine, ergots (peripheral), and prazosin(postural hypotension).
Congestive Heart Failure: dosage must be individualized and closely monitored by a physician during up-titration. Prior to initiation of Carvilol ,
the dosing of digitalis, diuretics and ACE inhibitors (if used) should be stabilized. The recommended starting dose of Carvilol is 3.125 mg twice daily for two weeks. If this dose is tolerated, it can then be increased to 6.25 mg twice daily. Dosing should then be doubled every 2 weeks to the highest level tolerated by the patient. At initiation of each new dose,
patients should be observed for signs of dizziness or light-headedness for one hour. The maximum recommended dose is 25 mg twice daily in patients weighimg less than 85 kg and 50 mg twice daily in patients weighing more than 85kg.
Carvilol should be taken with food to slow the raate of absorption and reduce the incidence of orthostatic effects.
Before each dose increase the patient should be seen in the office and evaluated for symptoms of worsening heart failure, vasodilation (dizziness, light-headedness, symptomatic hypotension) or bradycardia, in order to
determine tolerability of Carvilol. Transient worsening of heart failure may be treated with increased doses of diuretics although occasionally it is necessary to lower the dose of Carvilol or temporarily discontinue it. Symptoms of vasodilation often respond to a reduction in the dose of diuretics or ACE inhibitor. If these changes do not relieve symptoms, the dose of Carvilol may be decreased. The dose of Carvilol should not be increased until symptoms of worsening heart failure or vasodilation have been stabilized. Initial difficulty with titration should not preclude later attempts to introduce Carvilol.
If congestive heart failure patients experience bradycardia( pulse rate below 55 bets/min.), the dose of Carvilol should be reduced.
Hypertension: Dosage must be individualized. The recommended starting dose Carvilol is6.25 mg twice daily. if this dose is tolerated, using standing systolic pressure measured about 1 hour after dosing as a guide, the dose should be maintained for 7 to 14 days, and then increased to 12.5 mg twice daily if needed, based on trough blood pressure, again using standing systolic pressure one hour after dosing as a guide for tolerance. This dose should also be maintained for 7 to 14 days and can then be adjusted upward to 25mg twice daily
if tolerated and needed. The full antihypertensive effect of Carvilol is seen within 7 to 14 days. Total daily dose should not exceed 50 mg. Carvilol should be taken with food to slow the rate of absorption and reduce the incidence of orthostatic.
Addition of a diuretic to Carvilol, or Carvilol to a diuretic can be expected to produce additive effects and exaggerate the orthostatic component of Carvilol action .
Carvilol (Carvedilol) should not be given to patients with server hepatic impairment.
Overdosage may cause sever hypotension, bradycardia, cardiac insufficiency, cardiogenic shock and cardiac arrest. Respiratory problems, bronchospasmas, vomiting, lapses of consciousness and generalized seizures may also occur.
The patient should be placed in a supine position and, where necessary, kept under observation and treated under intensive-care conditions. Gastric lavage or pharmacologically induced emesis may be used shortly after ingestion.
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Ericsson Sells 2,185 Mobile Tech Patents To Newly Minted Troll, Unwired Planet
from the 2185-EXPLOITABLES!-NIB!-BID-NOW!!! deptWell, if it wasn't clear before, it's certainly official now. Unwired Planet (formerly Openwave), a former innovator in the WAP browser field, decided back in April that it was no longer interested in competing in the marketplace. Instead, it set the dials to "troll" and announced a new "corporate strategy," one that would punish actual innovators for innovating. CEO Mike Mulica announced a "multi-pronged strategy to realize the value of [Unwired Planet's] unique patent portfolio."
Now, an aider and abettor has thrown Unwired Planet 2,185 additional trolling devices.
Last week, Unwired Planet, a patent licensing company that once upon a time was an Internet services company called Openwave, announced a deal to acquire a portfolio of 2,185 U.S. and international patents and patents pending from Ericsson.In other words, Ericsson will profit from any litigation or settlements Unwired Planet manages to extract from tech companies. Pretty good money, if you don't mind being part of the problem. Mulica was on hand again to put lipstick on the troll-pig with plenty of words that dance around the shakedown-and-sue "business model" Unwired is calling a "corporate strategy" these days.
The company said the deal "significantly broaden[s] Unwired Planet's Mobile Internet-focused portfolio," including 753 U.S. issued patents related to 2G, 3G and LTE technologies. Ericsson will also contribute 100 additional patent annually to Unwired Planet from 2014 through 2018. Terms call for Unwired Planet to compensate Ericsson with certain ongoing rights in future revenues generated from the enlarged patent portfolio. Unwired Planet will also grant Ericsson a license to the Company's enlarged patent portfolio.
Unwired Planet CEO Mike Mulica said in a statement that his company looks forward to "leveraging a strong, multi-dimensional patent portfolio and furthering discussions with key industry players who are interested in licensing these inventions to protect and further build their product strategies."Well, just replace "leveraging" with "exploiting" and "furthering discussions" with "shakedown letters" and "interested in" with "forced to" and we've got ourselves a sentence! For that matter, let's replace "protect and further build" with "tentatively move forward in a highly litigious atmosphere, infested with tapeworms sporting UP/E logos."
The costs inflicted by the new hybrid tapeworm will, of course, be passed on to the end users in the form of increased costs, fewer innovations and East Texan accents. Ericsson will receive, in exchange for patents covering a broad swath of "telecommunications infrastructure" (and part of its
In addition, America itself will be blessed with several million more reasons for newly minted lawyers to embrace the patent field, which despite the best (but still very poorly done) efforts of the US government, still offers a good chance to make big money by doing little more than spamming successful companies with threatening letters.
Filed Under: mobile, patents, wireless
Companies: ericsson, unwired planet

subset: commoncrawl


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Wild Hills
The Wild Hills were part of the Wide World outside of the village of Ham, the home of Farmer Giles. They lay to the west and north of Ham, near the dubious marches of the mountain-country. The Giant who came blundering into Farmer Giles' fields usually went walking in the Wild Hills (it was only by making a bad guess when he was lost that the Giant came to lands inhabited by men). [1]


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Restorative Yoga postures help to relieve the effects of stress. Through the use of props such as bolsters, blankets, blocks, straps, chairs and the wall a completely supportive environment for total relaxation is created. Participants will be guided through a progressive series of supported postures. Each posture has a variety of benefits. While supported in these postures the student will be given guidance to explore the body and breath and learn the art of relaxation for body and mind.
Back to All Events
Earlier Event: February 20No preschool storytime today
Later Event: February 27No preschool storytime today


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Captain's Report
Contents of Report
Mission of the Boston Whaler 345 Conquest
Like most boats that Boston Whaler is introducing these days the 345 Conquest has been carefully designed to cruise, fish, or both. By creating a semi-enclosed hardtop pilothouse she becomes a four-season vessel, and her cabin below is a cozy place for a couple to hang out, or for a relaxed bunch of angler buddies to yak about the catch after fine day of fishing. She's also appealing to the person looking to downsize from the expense and maintenance of a big battlewagon. This boat can go out in most of the same conditions at a fraction of the cost, and operating expense.
She is also designed for the boater who is ready to move up from an open boat, one who is looking for some creature comforts, overnight capability, and a foredeck. This boater might be an avid angler, or a casual one who likes to do some cruising with the family.
Distinguishing Features
• Convertible Cabin V-Seating. By far this is the most unique feature on the 345 Conquest. At the push of a button, the dinette table lowers, the two seats pivot together and a berth is formed, complete with steps leading up to either side.
• Portside Helm Deck Dinette. This makes a convenient place for quick bites while still being able to keep an eye on the lines. It's also a nice spot to bring out the paper charts and go over the waypoint numbers from previous trips. Plus the aft seatback is reversible to convert to aft facing and remaining in the cockpit.
• Upper Galley Area. A cockpit grill and an optional freezer drawer conveniently located right near the helm deck sink make it easy to cook up a quick meal on the fly.
• Multi-tasking Cockpit. While some may think of this as a dedicated fishing machine, the simple fact is that it's also a capable cruising boat and that means she's going to be entertaining guests in the cockpit. All of the fishing amenities can be closed off, and optional bench seats to the stern and starboard side can be deployed to make a convenient gathering area.
• Level Flotation if Swamped. All Boston Whalers, no matter how large, float level when swamped. This is a claim that only a couple of other boats this size can make.
It is a pleasure to review a new boat that has been in so many ways designed and outfitted right -- as standard! We can hardly think of anything to quibble about with this boat. Her option list is quite creative, but only real boating connoisseurs will need to visit there.
First, Who is This Boat For?
The answer is she is built for adventuresome anglers who like to take off for the fishing grounds in pretty much whatever kind of weather is forecast. This is not a fair-weather-only boat. She is also for anglers who want to cover some distance, fish, overnight, then return to home port a day or so later without having to worry about a front moving in.
Cruise Ready. The 345 Conquest is also designed for cruising with the family. We'd gladly take her on long weekends out to remote island destinations or cruises to nowhere. While no boat is safe in more severe storms, the pop-up weather that we boaters have all encountered is a non-issue for this cruise-friendly vessel.
Entertaining? The folks at Boston Whaler have seen it all and they know many people buy boats for some of the simplest work and often "over-buy" simply because they either like the look of the boat, or are enamored with the vessel's potential. So, yes, the 345 Conquest can also be used for harbor cruising with several couples along to enjoy cocktails, grill burgers or fish on the boat's standard grill.
Thinking Out Of The Box. Here is where the "unusual" option comes into play: Big fishboat cockpits often don't lend themselves well to entertaining because while any man would happily sit on the cockpit gunwales, most women don't like to. Boston Whaler has thought of that, and makes optional fold-out bench seats for both the port and starboard bulwarks so three couples can comfortably sit. Fold the companion seat back forward, and the lucky owners can join in the conversation.
Major Features --
Hardtop with Integrated Windshield. In the standard model there are no downward sloping glass side windows leaving the top area open and breezy, which is how a lot of people in Florida and the tropics prefer it. Of course it can also be fitted with removable isinglass. The hardtop provides UV and rain protection, and gives the owner a place to mount the standard side and back curtains. Above, there is plenty of room for all kinds of antennas. Full side windows and even a glass bulkhead aft with a door are optional.
Wet Bar. The starboard wet bar comes standard with a refrigerator that faces inward towards the entrance to the helm area. When the freezer option is selected, the standard location of the refrigerator becomes the freezer and refrigerator is moved to the cockpit area.
Air Conditioning is Standard. There is a 12,000 BTU unit for the cabin below and an 18,000 BTU unit for the helm-deck/pilothouse. Both are reverse cycle so our friends up north can have a four-season boat. A/C requires shore power or a generator, so a 7.5 kW LOW CO gas generator is included as standard.
3 Outboards + Bow Thruster. The 345 Conquest weighs 14,200 lbs. (6,441 kgs.) dry, without engines. Add the standard triple Mercury 250-hp Verados, fill up all of the tanks, add gear, food, drinks, and six adults and we're looking at a boat that weighs over 20,000 lbs. (9,090 kgs.). Boston Whaler states that the minimum horsepower for this boat is 750, and her maximum rating is 1,050-hp. Since the previous version of the 345 was powered standard with twin 300-hp engines, we would trust the builder's judgment on this score. The standard 4 kW bow thruster makes docking this boat a piece of cake. A control upgrade to the outboard joystick is available.
Well-Equipped Galley. The 345's galley is small but it has a refrigerator/freezer, a microwave, and sink. What else is needed?
Sleep Tight. We are partial to boats that have U-shaped or V-shaped seating in the bow with a table. The reason is that we have spent many a night at anchor sitting at a table like this with friends, a bottle of Burgundy, some grilled fish with lemon juice and good conversation.
Automatic Table/Queen Bed. At the push of a button the V-seating and table morphs into a "queen size" bed and it's an exceedingly clever solution and a great use of space. The table automatically lowers and the twin seats "scissor" together to form the island berth, complete with stairs to both sides.
Want Two Singles? If two singles are preferred, then simply take the finger off the button once the table is lowered, and before the two side seats come together. The real beauty of this design is not only in its ingenuity, but in the fact that no filler cushions are needed and therefore no need to find room to store those fillers.
The Mid "Cabin." There is a mid "cabin" that is a crawl-in design but the overhead is really too low to use it as a sitting room. For sleeping it's fine. Its cushions make into another sleeping space with a privacy curtain. A bench seat is to starboard that opens out into a berth large enough for a single adult, or two kids. The wet head has a curtain to keep the sink and the VacuFlush toilet dry.
Optional Joystick Control. With multiple outboards, maneuvering around the dock with an adverse current running can be challenging, particularly for those not used to it. By equipping the boat with a joystick specifically calibrated for the 345 and the number of engines employed, all of the complex mental maneuvering calculations are done by the on-board joystick system.
Optional Upper Helm. Boston Whaler has a tower station available with a full set of controls and electronics including a small RayNav display and the Merc VesselView. Joystick-controlled boats will also have a second joystick in the tower as well. Having this tower not only lets the fish slicks be seen from a long way off, but it raises the height of eye from the 8' (2.4 m) level of the lower helm, to 14' (4.27 m), and that means the visible horizon goes from 3.5 miles (5.6 km) to 4.6 miles (7.4 km) out.
Feature Rich. There are really too many standard items on the 345 to mention -- often things that are usually optional on many boats in class. But just to suggest what is going on here -- 10" cleats, 4 spring line cleats, cockpit coaming bolsters, a hot and cold water shower in the cockpit, cockpit wet bar with refrigerator/freezer and sink, trim tabs, 3 pantograph windshield wipers with washers, dockside TV inlet with antenna, windlass, raw water washdown, isolation transformer, etc., etc.
Floats Level If Swamped. The folks at Boston Whaler hardly mention this little detail anymore, thinking that this horse has been beaten to death over the decades. Indeed, at times in this brand's long career it was the only thing really going for it. Times have changed. As we said, we think virtually everything has been done right on this vessel. From a seaworthy standpoint the most important thing about the 345 Conquest is the fact that she is a well-found express design which will easily shed green water. Indeed, even her side decks include molded channels to direct water directly over the side instead of into the cockpit.
A Tight Ship. Between this, her large, dual 2" (5 cm) deck drains to either side of the self-bailing cockpit, double-clamped hoses and ball valves all keeping her hull tight, frankly, little more is needed. But the 345 has more -- between her hull, inner liner and deck there is enough foam flotation to keep her level if she is somehow swamped. Call it extra piece of mind. We hope the company never abandons this dead horse.
The Boston Whaler 345 Conquest has a LOA of 35'11" (10.9 m), a beam of 11'8" (3.6 m) and a draft of 22" (56 cm). With an empty weight, including the optional tower, of 14,620 lbs. (6,632 kg) half fuel, two people and test power, we had an estimated test weight of just over 19,000 lbs. (8,618kg).
With a triple set of 300-hp Mercury Verado's turning 17p Revolution 4 propellers, we reached our top speed of 43.5 kts at 6000 rpm. At that speed we were burning fuel at a rate of 81.7 gph giving us a range of 192 naut. miles. Best cruise came in at 4500 rpm and 28.1 kts. That speed reduced the fuel burn to 39.6 gph which the 345 could keep up for just over 9 hours and 256 nautical miles while still holding back a 10% reserve. We reached planing speed in 4.4 seconds, accelerated to 20 mph in 7.1 seconds, 30 came and went in 11.1 seconds, and we continued accelerating through 40 mph in 16.1 seconds.
Simply put, the 345 Conquest is a joy to operate. She clearly has the pedigree of an offshore capable boat and it shows in her solid handling characteristics. She throws water well off to the sides and far enough back to present a dry ride. She has a natural bow high cruise attitude and adding trim just boosts the speed, it does not change the attitude. She has a narrow entry and cuts cleanly through large waves rather than pounding over them. Operations from the tower are comfortable, but it's clearly made for standing rather than sitting while driving. In the sitting position the helm it just out of reach so clearly the long hauls will be spent at the lower helm, likely on auto-pilot.
The folks at Boston Whaler tell us that the new model 345 Conquest has been designed with lots of customer input. Further, they say that she is built and equipped for veteran boaters, those who know what they want and need to go offshore safely. When comparing express fishboats, remember that the 345 Conquest is fully equipped. Don't compare her on price with other boats in class that need to be loaded up with options to get the job done. All of the needed equipment has to be paid for one way or the other.
Test Result Highlights
- Top speed for the Boston Whaler 345 Conquest (2019-) is 50.0 mph (80.5 kph), burning 81.70 gallons per hour (gph) or 309.23 liters per hour (lph).
- Best cruise for the Boston Whaler 345 Conquest (2019-) is 32.4 mph (52.1 kph), and the boat gets 0.82 miles per gallon (mpg) or 0.35 kilometers per liter (kpl), giving the boat a cruising range of 294 miles (473.15 kilometers).
- Tested power is 3 x 300-hp Mercury Verado with Joystick.
Standard and Optional Features
Marine Electronics
|VHF Radio
|Air Cond./Heat
|Battery Charger/Converter
|CD Stereo
|Head: Fixed
|Shore Power
|Trim Tabs
|Washdown: Fresh Water
|Washdown: Raw Water
Exterior Features
|Outlet: 12-Volt Acc
|Swim Ladder
|Transom Door
|Transom Shower
Boats More Than 30 Feet
|Bow Thruster
Hull Warranty
10-year limited structural
(It's quick and FREE!)


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How to Use the iPhone 4S Reminder App
The Reminders app on the iOS 5 software on your iPhone 4S isn't just any ordinary to-do list: Reminders on the iPhone can be tagged to your location, and it also works nicely with iCal, Outlook, and iCloud. iCloud can keep reminders in sync across all your iOS devices and computers.
Consider the power of tying a reminder to your location. You'll be notified of the items you must pick up at the supermarket at the moment you drive into the grocery parking lot. Or perhaps a reminder to call your spouse will pop up before you open your front door following a business trip.
Reminders are organized by lists — at the start, Apple supplies a general Reminders list, and a list that reveals the items you've completed — talk about a sense of accomplishment!
You can create your own lists, of course, perhaps one for groceries, another for the tasks you must do for the PTA. Lists show the due date or the location or both. You can swipe to the left or right to quickly jump from one list to another.
The two main ways to display reminders are list view and date view.
To add a reminder in list view, as shown in the following figure, tap the + button at the upper right, and type the name of the reminder you have in mind. To add or edit a list itself, tap the icon with the three bars at the upper-left of the Reminders screen. From the screen that appears, you can also search through all reminders.
In date view, shown in the following figure, you tap the calendar icon at the upper left. The screen displays a calendar that you can consult to see the reminders of a given day, as well as a search box that lets you find reminders without paying attention to a particular date.
To add or edit reminder details, tap the reminder itself from either the list or the date view. From the next screens, you'll be able to choose a date and time in which you want to be reminded, and choose a location. You can indicate that such location reminders appear When I Leave or When I Arrive at My Destination. With Location settings turned on, the iPhone can detect your current whereabouts. To specify the location to use for the reminder, tap Current Location, tap Choose Address, and select a name from the iPhone Contacts list that appears.
From Reminders, you can't type an address manually; you must choose the current location or select an address from Contacts. So if you want to add addresses to Reminders — the address of your kid's school, say, or the supermarket — you must first add them to your Contacts.


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Taking aim at tumors: Novel way of studying cancer may inspire new treatments
Many of the newest weapons in the war on cancer come in the form of personalized therapies that can target specific changes in an individual's tumor. By disrupting molecular processes in tumor cells, these drugs can keep the tumor from growing and spreading. At the forefront of this work are Binghamton University researchers, Susan Bane, and Susannah Gal, who are deploying a new tool in their study of an enzyme called tubulin tyrosine ligase, or TTL.
In developing these targeted therapies, scientists need to understand exactly what kind of activities within a tumor cell these drugs disturb. Bane, a professor of organic and biological chemistry, and Gal, an associate professor of biological sciences, are getting an insider's look at these cells and paying particular interest to the many cancer cells that contain less-than-normal levels of TTL.
Funded by the National Institute of General Medical Sciences, Bane and Gal's work focuses on microtubules, which are structures that provide part of the scaffolding that gives a cell its structure and also help chromosomes line up correctly during cell division.
These microtubules are made of proteins called tubulin and during the course of a cell's life, an enzyme called carboxypeptidase clips an amino acid called tyrosine off the end of some of these proteins. Later, TTL puts tyrosine back on the tubulin. No one knows the purpose of this cycle, but as Bane points out, "We do know that if you don't have that enzyme, you'll die."
In certain cancer cells, the cycle of removing and reattaching tyrosine has fallen out of balance: Too many tubulins lack tyrosine.
"Patients who have that characteristic in their tumor have a poor prognosis," Bane says. "And those tumors tend to grow more aggressively."
Hoping to learn more about the role of TTL in cancer, Bane and Gal are studying the removal and reattachment of tyrosine in live cells.
Bane has developed a way to mark tubulin with a fluorescent molecule using TTL, allowing the researchers to observe tubulin in action under a fluorescent microscope. The new labeling technique, using a small molecule, provides an easier way to watch the behavior of microtubules as cells divide. Cancer cells are often undergoing cell division at a much faster rate than normal cells, making the process a major target of cancer research.
Although Bane and Gal aren't trying to develop a new cancer treatment, their efforts to learn the role of TTL in tumor growth could someday make it easier to choose a treatment for a specific case of the disease.
"Potentially, someone could send us their tumor sample, and we could put it in our labeling system and say, 'Yes, that has a problem with the TTL system, and therefore you should be more aggressive with it,'" Gal says. "Or we could say, 'That's probably OK, so you can treat it with normal chemotherapy.'"
Bane and Gal are very hopeful that this new approach will then allow clinicians to treat cancer far more effectively as therapies would be personalized to an individual's tumor.
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Model yes. Role model, no.
Naomi Campbell, who recently took center state in the ongoing war crimes trial of former Liberian dictator Charles Taylor, has battled drugs, assaulted aides and sought help with anger management. She's certainly beautiful on the outside, but ....
"Listen, I make many mistakes. Many mistakes. I'm not a perfect human being," Campbell told Interview magazine. "I have to learn from my mistakes. And a lot of the ones I've made have been public. So I always get nervous when people speak about something that sounds like a role model, because I don't know if I've been a great role model myself."
A pictorial in the magazine has Campbell, 40, in a black dress posing like a dominatrix over a heavily tattooed and submissive male model.
Campbell testified last month before an international tribunal in The Hague about receiving diamonds from Taylor after a gala dinner in South Africa in 1997. Taylor is accused of trading in "blood diamonds" in exchange for helping rebel factions during the 11-year civil war in Sierra Leone.
Selected Reading: Interview magazine, Hague Justice Portal, The New York Times.


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Chicken Burger Recipes
Chicken Kebab Burger
Chicken kebabs are both healthy and nutritious. The poultry is mixed with garbanzo beans and seasoned with Indian spices. I usually make this recipe when I have leftover chicken. We had company for dinner so I decided to make a complete meal out of them and serve them as burgers. I double-stacked 2 patties with tomato slices, cilantro, fresh mint, raita (Indian yogurt sauce), red onion and fried shallots.
The weather is getting clearer and sunnier by the day, so next time you think of a barbecue, you should consider making chicken shami kebabs (that's the real name of the dish). If you're planning a fancy dinner party, you could serve them as tapas. Bite-size burgers are getting very popular. Either way, you should definitely try this fresh take on an American classic.
Full Recipe...


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My office is now in functioning form. It's not finished but it's an open space for me to disappear to every day to log hours and to finish both work and fun projects.
I love having my own space! It's wonderful. Every detail has been so liberating – from organizing my file structure and having a place to store work materials (my 9-5 job), to finding a home for every little craft object that participates in the clutter of everyday life around here.
Here's a sneak peek at my organizing in action, please ignore those crazy wires (need to find a solution for those soon):
That's a new curtain, too! I created that for this project early last year and realized very recently how perfect it was color-wise for this space – it's Cassandra Seaspray and it can be found here. The french doors between the kitchen and office are glass so it can be difficult to 'disappear' when Liv's nanny is over to help play with her while I'm working. Plus, guests get a little privacy in the room.
Here's the desk – clean and clear. Knowing me that won't last long.
I used a combination of Target and One Kings Lane fabric boxes, See Jane Work brown portfolio boxes and metal baskets, and West Elm white lacquer magazine butlers and file cabinets to outfit the shelves. The look I'm hoping to achieve is organic – plenty of mixed textures and naturals colors.
I've learned an important lesson after having a few work spaces: you must love your organizational tools and the way your office looks when tidy, or you'll never aspire to it at the end of a long day.
That big gap there on the left is where the printer will sit. It's nice and close – none of this wireless business that would *sometimes* allow the computer to communicate with the printer on its own free will.
Here's an angle of the desk and left bookshelf. I have to soak in as much clean and clear desk as I can now… it may be a while after my organized desktop chaos takes over.
Treasures include an estate sale yellow glass candy jar that doubles as nook to stash rolls of ribbon, a wax bird from West Elm (on sale) a See Jane Work metal basket that houses fabric remnants I'm currently working with (the rest are sorted by color in the big OKL fabric boxes at the bottom of the shelf) and a favorite photo of Liv and I printed on glass (have you heard of Fracture? I discovered it through a Groupon). I still need to take some time to label all of the boxes. Labeling, labeling is awesome.
I brought this ceramic urn back with me after our trip to Iowa for RAGBRAI. I found it at a little garden shop in Woodward, IA and managed to stuff it in my suitcase. Now it's home to paint swatches that we frequently pull out when working on the house.
All the while I was working on this particular afternoon, Liv gleefully watched on from her chair in the kitchen. Moms have got to take full advantage of nap and meal times!
Ordering all of the office organizational supplies can be a daunting task, and I find that having a clear layout where each and every object will go is helpful. I made this rough sketch before purchasing supplies and it helped to determine how many of what was actually needed.
I deviated from plan a bit, but all in all I'm less distracted and more on target with a careful plan laid out in advance.
Man this is a tough room to photograph – too narrow! But here's one last shot before all the techy stuff is added back in:
PS I need a camera expert – what's the ideal setting for indoor photos? What a steep learning curve this new SLR camera is! Indoor photos especially…
For more Office Makeover posts, check out: wall collage part 1, fabric bulletin board inspiration, (new) inspiration board, new lamps, wallpapering open shelves, finding the perfect credenza, new trim, dining table-to-desk, a new desk & bookshelves, installing remnant carpeting, grasscloth wallpaper, painting the office nook, finding carpet for the office, chocolate brown wall ideas, plastering progress, inspiration for a diy desk, back in action!, desking hunting for under $300, bookcases under $300,inspirational rooms, room layout options, demo part 1 & demo part 2.


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Slow-Cooker Chili
Hello all! And a happy Monday to you! I hope you all had an amazing weekend full of fun! Our weekend was pretty great. Nice and relaxing.
Fall has officially started! The autumn equinox has begun! And I'm continuing to share some of our favorite fall recipes! Today I present you with one of the most rewarding recipes: Slow-Cooker Chili! I say most rewarding because it requires less than 10 minutes of work for a DELICIOUS payoff!
- 1 pound ground beef
- 24 ounces tomato sauce
- 1 tbsp tomato paste
- ¼ cup water
- 1 can black beans, drained
- 1 can kidney beans, drained
- ⅛ tsp ground cayenne pepper
- ¼ tsp sugar
- ¼ tsp oregano
- ¼ tsp black pepper
- ½ tsp salt
- ¾ tsp ground cumin
- 2 tbsp chili powder
- In a medium skillet, cook ground beef over medium-high heat until evenly brown. Drain.
- In a slow-cooker, combine cooked ground beef, tomato sauce, tomato paste, water, beans, cayenne pepper, sugar, oregano, pepper, salt, cumin, and chili powder {AKA: dump everything in!}. Mix thoroughly. Cook on medium heat for 4 hours.
Another amazing part? When you come home/go into the kitchen it will smell amazingly like chili! It smells divine!! My favorite way to have chili? Turn it into chili mac with some pasta! Top it with a little sour cream and cheese! The hubby loves his with toppings but nothing else.
How do you like your chili??? On a hot dog? Over fries? Turned into chili mac like me? Or do you love the original, straight


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WORCESTER � A 19-year-old man shot several times in the parking lot of the Mekong Market on Main Street early Saturday morning is in good condition and is expected to recover, police said.
The victim, who police have not identified, was found conscious on nearby Ethan Allen Street just before 2 a.m. Police said he was uncooperative and refused to discuss what had happened when he was found on Ethan Allen Street and again later in a local hospital.
Residents of Ethan Allen Street this morning said they didn't hear the shots and don't know the identity of the victim.
Detectives found unspecified evidence in the parking lot at 747 Main St., where the shooting happened, and are continuing to investigate, according to police.
Contact reporter Thomas Caywood at email@example.com or follow on Twitter @CaywoodTG


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BALTIMORE – UMBC women's basketball shot a season-best 56.1 percent and had five players score in double-figures en route to scoring a season-best 77 points in a 77-62 victory versus Vermont in America East action on Sunday afternoon at the RAC Arena.
In a game that saw 10 ties and 16 lead changes, the Retrievers took the final lead of the contest with 4:03 remaining, which sparked a 15-2 run for the black and gold.
Freshman guard Taylor McCarley (Bowie, Md./Academy of Holy Cross) hit four-of-five from the field and 10-of-12 from the charity stripe to finish with a team-high 18 points, five steals and five rebounds. Freshman forward Sara Tarbert (Delta, Pa./Kennard-Dale) added 14 points, five rebounds and five assists, while sophomore Liz McNaughton (Fairfax, Va./Fairfax) matched a career-best with 12 points and added six rebounds. Sophomore center Bridget O'Donnell (Belle Mead, N.J./Montgomery) connected on five-of-six shots for 10 points and pulled down seven boards.
UMBC snaps an 11-game skid to improve to 3-22 overall and 2-11 in league play, while Vermont drops its fifth straight to fall to 6-19 overall and 3-9 in America East action.
The Retrievers opened up an eight point lead five minutes into the contest, but Vermont scored the next 13 points to take a 15-10 advantage. Vermont took a 29-27 lead into the break, despite being held without a field goal in the paint throughout the half. UMBC shot 52.4 percent from the floor in the half, but turned the ball over 14 times in the period. UVM junior Kayla Burchill scored 11 of her game-high 27 points in the half and pulled down seven of her eight rebounds.
The teams traded baskets throughout the second half until the Retrievers were able to break the contest open with under four minutes remaining in the contest. UMBC hit 15-of-17 free throws in the final four minutes of the contest to hang on for the victory.
Vermont snagged 12 of its 18 offensive rebounds in the second half and scored 18 points off its second opportunities, but UMBC shot 60 percent from the field and connected on 25 of its 28 free throw attempts in the half. Freshman guard Emily Russo (Woodbine, Md./Glenelg) scored 11 of her season-best 13 points in the second half.
The Retrievers held a 32-8 advantage at points in the paint, and shot a season-low three shots from beyond the arc.
UMBC closes out its three-game homestand versus Stony Brook on Wednesday, Feb. 19 in its annual Play4Kay contest. Tip-off is set for 7 p.m. at the RAC Arena.
Game Notes
-UMBC snaps a two-game skid versus Vermont, but the Catamounts hold a 14-10 advantage in the all-time series.
-UMBC's 77 points were the most scored in a game since Feb. 2 of last year when the Retrievers posted 86 points versus Maine.
-The Retrievers' three three-point field goal attempts were its fewest in a game during the Phil Stern era.
-Taylor McCarley tallied a season-best two blocks.


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In comments, and in 300 words or less, give us a snippet from your novel that will bring a smile, incite a giggle, or make us laugh out loud. Don't forget your buy link and website/blog link. Have fun!
Come see my snippet on Exquisite Quills' Tickle Us Tuesday! http://exquisitequills.blogspot.com/


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Savannah Guthrie Named Co-Anchor, 'TODAY' Confirms
Savannah Guthrie will be the new co-anchor of 'TODAY' starting July 9, the show officially announced on June 29.
Just one day after Ann Curry told viewers she was leaving her position as co-anchor, TODAY has named Savannah Guthrie as her replacement.
Guthrie joined the show as the host of the third hour in June 2011 and also contributes as the shows chief legal analyst.
The new TODAY team will include Matt Lauer, Savannah Guthrie, Al Roker and Natalie Morales and will debut on Monday, July 9th.
What do YOU think about this news, HollywoodLifers?
–Dory Larrabee
More TODAY News:
- Ann Curry Announces Leaving 'Today Show': 'Sorry I Can't Carry Ball Over Finish Line'
- Meredith Vieira Denied Offer To Replace Ann Curry On 'Today Show'?
- Ann Curry, You've Got Nothing To Apologize For (Re: 'Today' Show)


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U.S. Official: Sgt. Bowe Bergdahl Has Declined to Speak to His Family
Doctors Moving Slowly on Treatment because of Swirling Controversy Over Prisoner Swap
WASHINGTON—Sgt. Bowe Bergdahl has declined to speak to his family after five years in captivity, according to a U.S. official familiar with matter, one sign of the difficult journey the 28-year-old soldier faces as he tries to reclaim a semblance of a normal life amid a raging debate over his capture and release.
Doctors treating Sgt. Bergdahl at a U.S. military hospital in Germany are moving slowly because of the controversy, which is complicating what would in any case be an arduous recovery. Sgt. Bergdahl has said that...


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Tzipi Obziler (ODU'95) Getting Active In Real Politics
By ODU Athletics
Nov. 14, 2008
By Bob Larson -Business News
Politics is all about ups and downs and such has been the case for Israeli tennis player turned politician Tzipi Obziler (ODU'95) in the last few weeks.
Just a few weeks ago in Shrewsbury, England 35 year-old Obziler suffered the ignominy of losing to an opponent 21 years her junior - the much heralded British 14 year-old and Wimbledon junior champion Laura Robson.
But Obziler clearly had other things on her mind. A committed member of the Green Givatayim party, she decided to stand as a candidate in the local elections that took place earlier this week. And she was duly elected to the Givatayim municipal council after her party won two mandates.
One of women's tennis unquestioned veterans - she made her competitive debut on the satellite circuit nearly 20 years ago - 176th ranked Obziler insists she is not contemplating retirement although her position may force her to cut back on a playing schedule that this year alone has seen her contest 25 events including all four Grand Slams and the Olympic Games as well as representing Israel in Fed Cup.
Obziler was not the only sportsperson to figure in the Israeli elections. Arkadi Gaydamak, who owns British Premier League soccer club Portsmouth, failed in his attempt to be elected Mayor of Jerusalem. However Judoka Yoel Rozvozov, a European Championship medalist at judo, was elected to the Netanya city council.
Obziler ranked No. 1 collegiate women's tennis player in the country in the fall of 1995 while at ODU.She captured the National Clay Court Championship that season, before returning to Israel to begin her professional tennis career.
Obziler competed in the Olympic games in Beijing for her native Isreal in both singles and doubles.


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Roy Halladay pitched his way into history Saturday as he pitched the 20th perfect game in the history of baseball as the Phillies beat the Marlins.
On a night when most eyes in the City of Brotherly Love were on the Flyers playing in the Stanley Cup in Chicago, Doc was surgically cutting apart the Fish in Miami.
"It's never something that you think is possible," Halladay said.
Doc's line -- no runs, no hits, no walks and no base runners on 115 pitches. 27 up and 27 down.
And just for good measure Doc struck out 11 Marlins.
"I don't know what to say," Halladay said. "Early in my bullpen I was hitting spots more than I have been. I felt like I just carried that out there."
He was the second Phillie ever to be perfect. Hall of Famer Jim Bunning threw a perfect game on Father's Day 1964 against the Mets. The last Phillies to pitch a no-hitter was Kevin Millwood in 2003.
Halladay credited catcher Carlos Ruiz for a smooth ride.
"We felt like we got in a groove early and about the the fifth or the sixth I was just following Chooch," he said. "I can't say enough about the job he did today. Mixed pitches. For me it was really a no-brainer."
They needed every bit of Halladay's perfection as the Phightins only managed to score one run on seven hits.
Doc outdueled Marlins' ace Josh Johnson who allowed only an unearned run in seven innings.
But despite Johnson being good, Halladay was better.
It was nights like these that led Phillies general manager Ruben Amaro, Jr. to give up a bevy of prospects and Cliff Lee (basically) to ensure Halladay could pitch in Philly.
It was the second perfect game in the majors this month alone, Dallas Braden doing it for Oakland against Tampa Bay back on May 9. It's the first time in the modern era that there were a pair of perfectos in the same season.
Congrats Doc -- what a "Halladay" weekend night.
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Joe McCoy
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Finest premium cotton is used for this t-shirt. The dying process is done after the t-shirt is made, giving it a better colour fade after multiple washes. Features original McCoy Sports tag.
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Taking it's cues from each changing era of the American experience in Sportswear, Denim and Workwear, Joe McCoy continues to manufacture unchanging products designed to last generations.
When unraveling the cultural history woven together on the American continent, the singular contribution of one legendary figure comes quickly to mind, Joseph Getting McCoy. As the son of immigrants, Joe McCoy combined the traditions of his parents with ideas born of the the new world. he rode the mid-nineteenth century frontier wave eastward to frame with his innovate and tough brand of textiles. The arrival of work pants reinforced with copper rivets heralded the dawn of the new era. In the early twentieth century, motorisation, prosperity and strong demand for durable goods and luxuries rapidly spread across the country. Labourers wanted tough and affordable workwear. Gatsbyian playboys wanted suits and coats of the finest materials. Not many years later this deepening polarity gave way to a bubble-bursting depression and world-changing war, followed by a radical shift in clothing needs. The garment industry was revolutionised as government contracts poured in for innovative and functional clothing. When the dust settled, American garments were recognised round the world for their function and originality. Taking it's cues from each changing era of the American experience in Sportswear, Denim and Workwear, Joe McCoy continues to manufacture unchanging products designed to last generations.


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Recall 11V258000
Transmission Intermediate Shaft May Fail
Recall Details
The right intermediate drive shaft may suffer from noise and excessive wear due to misalignment with the transmission right side output gear. As the splines on the intermediate shaft wear, a whirring and/or whining noise may develop and eventually result in damage to the automatic transmission output gear. Severe wear of the splines could result in a loss of drive force to the wheels, increasing the risk of a crash. Dealers will inspect the right side output gear and intermediate shaft and replace worn parts as necessary. Alignment of the intermediate shaft will also be inspected and corrected if needed. This recall is expected to begin during May 2011. The Kia recall number is SC089.
Our Quick Take
A whirring or whining noise may develop from the transmission. This could lead to failure of the right intermediate drive shaft, which can cause a loss of engine power to the drive wheels, increasing the risk of a crash.
What Should You Do?
This could be considered a medium priority recall; this would change to high if any abnormal noise is noted from the transmission area. Please contact your Kia dealer. They will check to see if your specific vehicle is affected and advise you on what to do next. Always have your vehicle identification number (VIN) handy when you call.


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It takes talent to be the world's best not-for-profit educational organization for adults. When it comes to creating educational travel adventures that enrich the lives and fulfill the dreams of adults, there's no organization better than Road Scholar. What's our secret? Dedicated and talented staff who believe in our mission.
Our headquarters is in Boston and we have offices throughout the United States, in the United Kingdom and Australia. We are always on the lookout for people who are excited by, enthusiastic for and believe in the power of our mission.
How far can you go with Road Scholar? Our president started in our call center. Watch Jim Moses tell his story.
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After your first year, we'll match your automatic 5% contribution to a 403(b) Retirement Plan. We may even add to it – in 2018, Road Scholar added another 5% for a total of 10%!
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Road Scholar values and supports individual differences and strives to create an environment that contributes to the success of both the individual and the organization. As an Equal Opportunity Employer, we consider applicants for all positions without regard to race, color, religion, gender, national origin, age, sexual orientation, pregnancy, illness, marital or veteran status or disability or any other status protected by applicable law.
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Butch rising
The long goodbye from Beaumont Independent School District Superintendent Dr. Carrol "Butch" Thomas is still an ongoing drama at the district's Harrison Avenue headquarters. Apparently he isn't willing to just retire and spend his days counting the loot he stashed during his 16 years as one of the highest paid school superintendents in the state. Word out of Austin is that Thomas has applied to Gov. Rick Perry for appointment as commissioner of public education for the state of Texas. If he gets the job – which is far from certain – he surely would make no less than Robert P. Scott, who left the job on July 2 making $186,300 a year. Although that is only a little more than half the $360,000 Thomas made at BISD, it is still a pretty good income for a retired guy.
Thomas was recommended for the job by Roscoe C. Smith, member of an ad-hoc Dallas group of educators, politicos and preachers known as the Coalition for an Accountable System of Education (CASE), which was formed last year in an unsuccessful attempt to get a former Dallas school district superintendent reappointed to his old job. Smith wrote Perry recommending Thomas, who at the governor's request submitted a thick, hard-bound book about himself labeled a "profile" that describes the "educational leader and strategist" we have all come to know.
This book runs into trouble in the opening sentence of the section labeled "Biography," which describes Thomas as "a highly sought after educational leader who is renowned for his work in inspiring people in communities and government to achieve the best for those who depend on public education." Maybe that's true in some parallel universe, but not here in Beaumont where Thomas and his cronies have sought to divide the community along racial lines to cement their power. They have largely succeeded with this divisive ploy, much to the regret of many city residents of both colors who lament the byproduct of this tactic — a Beaumont divided like it hasn't been for 40 years.
The fourth paragraph of this sham bio revisits a tired BISD talking point about some ephemeral online magazine that named BISD one of the nation's Top 10 school districts – in exchange for a list of BISD vendors to whom they could sell advertising. The whole Top 10 rating is a blatant lie as even the most dimwitted functionary at BISD headquarters must surely know. A recent report by the Texas Education Agency shows only four out of 23 BISD schools evaluated in 2012 meet Adequate Yearly Progress standards, the federal accountability system under the No Child Left Behind Act. With 19 out of 23 BISD schools failing to meet minimal standards, anybody calling that a Top 10 track record needs to take some remedial math.
You might want to give Rick Perry a call. If you think Butch has done a good job here, tell that to the guv. But if you've had your eyes and ears open for the past 16 years, tell him what Thomas has done to this community.


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Sept. 26, 2006
SANTA CLARA, Calif. - Any fears of Sunday's women's soccer contest being a "trap game" after Friday's emotional 3-0 defeat of No. 3 UCLA were quickly put to rest by the No. 5 Santa Clara Broncos as they dominated Sunday's contest against the No. 14 CS Fullerton Titans. Outside back Marian Dalmy accounted for both Bronco goals and the defense recorded its seventh shutout of the season in the 2-0 victory at Buck Shaw Stadium.
The Broncos (8-2-0) will continue their current five-match homestand Saturday night, Sept. 30, as they take on the Stanford Cardinal in a 7 p.m. contest at Buck Shaw Stadium. Tickets are available by calling (408) 554-4660 or by clicking here.
"This weekend was huge, I think that we knew we needed to play real well against UCLA, and we did," Dalmy, one of the team's captains, said of the momentum that the weekend's wins give the Broncos. "To carry it on is such a big part because we're moving deeper into our season now and playing well every game and getting better is what we need to focus on."
Santa Clara outshot CS Fullerton (4-4-1) by a staggering 23-5 margin Sunday afternoon, getting plenty of solid opportunities from a variety of players as seven different Broncos put at least one shot on frame. Only a gutsy performance in defeat by Titan keeper Karen Bardsley kept the match from becoming a complete rout, as she made nine saves on the day, including a couple from point-blank range.
Dalmy netted her first two goals of the season in the contest, the first coming off of a nice feed from Kiki Bosio on the far side, which Dalmy took in stride and walked in along the far post and beat Bardsley from a tough angle for the match's opening score. For Bosio it was her fourth assist of the season.
"Kiki was able to hold the ball so well that it helped me get around for her pass, and once I took the touch, I looked up, saw I had room and realized that no one was coming at me so I took the shot," Dalmy said of her first goal.
About 15 minutes into the second half, Dalmy again penetrated the box along the goal line, this time coming from the near side, when she was tripped up and taken down and awarded a penalty kick just after the 60-minute mark. Her shot skipped past Bardsley and into the lower-left corner of the goal to give SCU the two-goal advantage.
The Broncos continued to press, outshooting the Titans 16-2 in the second half, but only the play of Bardsley kept them from doing further damage. Lexi Orand had a few chances stopped, while Chioma Igwe got off a bending shot from about 21 yards that looked headed into the upper-left corner but Bardsley got enough of the ball to deflect it just wide. A Brittany Klein shot was blocked wide in the 75th minute, and after a loose-ball scramble on the ensuing corner kick, Kelly Giddings got off a rocket from just inside the top of the box that Bardsley just managed to get in front off and keep out of the net.
Meagan McCray and Julie Ryder each took a half in goal and made a save for the Broncos Sunday, while Carrie Schuler made her first appearance back on the pitch since suffering a knee injury over two years ago on Sept. 5, 2004 at Notre Dame, entering the match and playing on the back line.


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Wüsthof Stainless-Steel Kitchen Shears
These heavy-duty shears are destined to become one of your all-time favorite kitchen tools. As versatile as they are efficient, they're great for everything from taking apart a whole chicken and snipping dried fruit to harvesting fresh herbs, cutting flowers and opening bottles.
- Forged from one piece of tempered high-carbon steel for exceptional strength.
- Blades have finely honed edges to guarantee precision cutting.
- Steel-tooth insets in handles twist open bottle and jar caps.
- Handles are designed for a secure, comfortable grip.
- Shears come apart for easy cleaning and sharpening.
- Made in China.
Dimensions & More Info
- Made in Germany.
Use & Care
- Hand-wash with warm water and a mild detergent. Rinse and dry immediately.
- Sharpen knife at home using a sharpener designed for scissors, or have them sharpened by a professional.
Gift with Purchase
Receive a $25 Williams-Sonoma Gift Card with your purchase of Wüsthof cutlery. Print Coupon
Registrant: Receive a free gift when you add qualifying Wüsthof products to your registry. Print Coupon
Shipping Information
UPS can deliver most in-stock items within 3–5 business days. UPS is unable to deliver to P.O. boxes.
Shipping Rates
The shipping rate varies depending on your order total and shipping destination. View Shipping Options and Charges.
Next Day Delivery
For an additional charge of $26 per address, we can expedite delivery to most destinations. This service is not available for some oversize items, items shipped directly from the supplier (including perishable and custom-manufactured items), out-of-stock items and items to be shipped outside the contiguous 48 states.
Orders received by 9:00 p.m. ET Monday through Thursday will arrive the next business day; orders placed Friday through Sunday will arrive on the following Tuesday.
Return Policy
At Williams Sonoma, we take great pride in the quality and craftsmanship of our products. Attention to design, materials, safety and construction are our priority. Upon receipt, please inspect your purchase and notify us of any damage; we will arrange for a prompt replacement.
If within 30 days, you are dissatisfied for any reason, you may return your purchase for a refund of the merchandise value. An original receipt or gift receipt is required for all returns and exchanges. Returns with a gift receipt will be refunded in the form of a Merchandise Credit for the amount indicated on the gift receipt. Returns with original receipt will be refunded in the original form of payment, cash and check refunds over $100 will be issued as a company check (may take 14 business days from time of request).
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Wüsthof Stainless-Steel Kitchen Shears
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Phill Martin - Cosmic Shimmer Ink Mist Spray - Chic Grey Blue
Any 3 Cosmic Shimmer Ink Spray Mists for just £9.00!
Choose any 3 Cosmic Shimmer Ink Spray Mists for just £9.00!
Please note this offer cannot be used in conjunction with a promotional code. If entering a discount code during checkout, this offer will be removed and the new discount applied across all individual items.
Expires 31st December 2019
These Ink Spray Mists from Cosmic Shimmer are so versatile. You can mix with the Cosmic Shimmer White Chalk Paint or Cosmic Shimmer Pearl Shimmer Paint to create new colours to paint with. Use Cut-N-Dry Foam to create your own ink pad or pop some ink onto craft sheet and use with a brush to colour in images. You'll acheive fantastic results with this great product!
UK DELIVERY FREE Crafty Super Saver Delivery
FREE Crafty Super Saver Deliveryon all orders £20 and over for anywhere in the UK & Channel Islands. (Delivered in 3 to 7 working days)
Priority Post Delivery: £3.95
Same day dispatch if ordered before 3pm. (Delivered in 1 to 3 working days)
Speedy Next Day Delivery for UK only: From £6.95
Normally arrives Next Working Day if ordered by 1pm. (Saturdays & Sundays are not classed as working days) Powered by DPD Local Predict delivering your parcels, your way!
Euro Priority Delivery: From £3.99
Typically delivered within 4 to 7 working days.
Global Priority Class: From £7.99
Typically delivered within 5 to 10 working days.
For further information please see our UK Order & Delivery Information or International Order & Delivery Information & our Help Guide
Shop in total confidence at Craftasmic.co.uk in the knowledge that all orders are backed by our 14 day no-quibble money back guarantee. If for any reason you are not 100% satisfied with any of our products we will be pleased to refund or exchange your purchase.
All we ask is that you return your items to us, in perfect condition and with their original packaging within 14 days of delivery. The cost of the return postage is borne by you, but we'll be delighted to send out any exchanged items free of charge.
If you're unfortunate to receive items which need to be returned due to faults or transport damage, don't worry as we're happy to help with this. Simply contact us and we'll look to resolve the problem. Should you need to return the item to us, we'll then issue a full refund or exchange and will also refund your return postage.
We can assure you that the whole Craftasmic Team is focused on delivering an exceptional shopping experience that will leave you 100% satisfied!
For further information please see our Returns Information & Help Guide
- Colour: Blues, Greys/Silver
- Weight: 70g
Item: CSPMMGREY
Cosmic Shimmer Ink Spray Mists can be used in a variety of ways. Use as a spray mister through masks and stencils to create amazing backgrounds, mix with paints, change the colour of your ribbons and more! These sprays can be used on card, paper, wood and fabrics. Chic Grey Blue is a colour by Phill Martin.
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Native Voices at the University of Washington is a center where students, faculty, and independent producers create documentaries and media research that contributes to the understanding, strengthening, and support of Indigenous people and communities. Native Voices envisions filmmaking from a decolonized, community based, and global perspective. We offer students and producers the opportunity to explore documentary from an Indigenous perspective, and to create projects that speak to critical personal, social and political issues in their lives.
Documentaries produced in our center have won awards and been screened at Sundance, the American Indian Film Festival, the National Museum of the American Indian, the Museum of Modern Art, and many other venues. Our films are used in Indigenous education throughout the world.


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Doodle Stitch Along with us!January 07, 2011, 10:00 am Posted by guestblogger
Hey there crafty people! This is Aimee Ray, the author of Doodle Stitching: The Motif Collection. I've got a fun project for you, a Stitch Along! We'll be giving away a free embroidery pattern motif a week from my book for the next 4 weeks, and we'll all stitch them up together into a super cute mini quilt. The motifs are from the Woodland Fairy Tale set (one of my personal faves), and you can get the first one today: first up is the Gnome and Mushroom (click the linked text to download a PDF of the motif, which includes two size options). Start embroidering them right away! Get creative and use whatever colors and stitches you like. (If you've never embroidered before, this is a great time to start! If you need some beginners tips, visit my blog for some free tutorials.
Read more after the jump!
I'll be posting my progress from the previous free motif each Friday, and in our Stitch-a-Long flickr group. We would LOVE to see your photos too, so please share them as we go along!! If you don't already have a flickr account, it's free to join. (Update: there's a good conversation happening over in our group pool regarding plans for the final mini quilt sampler, just in case you're curious or have questions.)
At the end, I'll be putting my embroideries together into a mini quilt, but you can use yours for anything you can think of. It will be great to see how everyone does different things with the same patterns!
Sound like fun? I hope so! But, there's more! Lark is generously having free giveaways each Friday as well! Read below for details. I hope you'll join us!
To enter for a chance to win an embroidery kit and a copy of Doodle Stitching: The Motif Collection, leave a comment on this post by 11 p.m. EST on January 13, 2011. Any comment will do, but we'd love to hear about your creative new years resolutions (if you have any). We'll randomly select a winner and announce the results on January 14. Click here for the official rules.
Thanks to everyone for sharing your creative resolutions with us… how very inspiring! How awe-inspiring! It was wonderful to see how many people are working to bring a little bit of creativity into their everyday lives! Best of luck… we completely, absolutely, 100% salute you!
And now for the winner…. congrats to Veronica Leigh who wrote: "This year, I plan on stitching more and going out for more creative endeavors (upcycling as much as I can, attempting to knit once again)." Go, Veronica!
Looking for motif #2? Grab it here!


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Learn how to create visual stories with filters, emoji, and animated stickers using the free Clips app on iPad. You'll collaborate with others and create a short video to share. Bring your iPad or we'll provide one. Recommended for all skill levels.
More about Skills
In Skills sessions, you'll get familiar with the fundamental techniques and tools of a creative topic. These are different from Product sessions, which are for anyone completely new to a product or app.


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Adults with
epilepsy may wonder if their children will also
develop epilepsy. Whether a family history of epilepsy (genetics) increases a
person's risk for the disorder partly depends on what type of
epilepsy the family member has had.
Several types of childhood epilepsy may be passed from parent to
child. These include benign focal childhood epilepsy, childhood absence
epilepsy, and juvenile myoclonic epilepsy, which have no other known
If you developed epilepsy as a result of a head injury, stroke, or
other clear causes, you probably will not pass the condition on to any children
you have. But certain genetic factors may have made you more likely to
develop epilepsy after the injury, stroke, or other cause. And you might pass
on these genetic factors to your child.
A child of a parent with epilepsy may or may not develop the
disorder. Family history is a risk factor, but many people with epilepsy have
children who never develop it. Research on the role of genetics in epilepsy
continues. But knowledge about the issue is still quite limited.
Next Section:
Previous Section:
Last Revised:
August 26, 2011
Healthwise Staff
Medical Review:
Susan C. Kim, MD - Pediatrics & Steven C. Schachter, MD - Neurology
This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
To learn more visit Healthwise.org
© 1995-2012 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.


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Hire Silent Disco in Renfrewshire
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40 Pages of Question And Answers on Roosevelt Island Cornell NYC Tech - Also, Community Board 8 Roosevelt Island Cornell Task Force Meeting Tonight To Discuss Recommendation To Full Board
Community Board 8 Roosevelt Island Cornell Technion Task Force will be meeting tonight. According to CB 8:
Meeting Date:While the meeting is open to the community and anyone is allowed to attend, there will no public statements or comments taken. The purpose of this meeting is for the Task Force members to discuss among themselves the information they received from Cornell and all other interested parties in order to draft a resolution recommending action by the full board.
Tuesday, December 4, 2012 - 6:30pm
Meeting Location:
Manhattan Park Theatre Club
8 River Road, Roosevelt Island
New York, NY
Executive Session of Task Force to craft Cornell-Technion resolution
During the November 26 Cornell Roosevelt Island Task Force meeting, Community Board 8 Chair Nicholas Viest explains what will happen at tonight's meeting
Below are some answers from Cornell NYC Tech to questions submitted during the November 26 CB 8 Roosevelt Island Task Force meeting. (Full video of meeting is here). The full question and answer response from Cornell NYC Tech is here.
Q - Looking for partnerships to support early childhood education (Page 1)Click here for all 40 pages of questions and answers and here for the Cornell NYC Tech Draft Environmental Impact Statement.
A - We are willing to work with all age groups of children on Roosevelt Island, although we plan to focus our efforts on students who are in middle school as this is a pivotal time to interest them in the STEM (science, technology, engineering and math) fields. Our interaction will involve direct student interaction, support for teachers, and family engagement. We have initiated discussions with, and look forward to continuing to work closely with PS/IS 217 to determine the specific programs that will be most useful to make that school a model in STEM education. Re: timing, while significant programming requires faculty and graduate student involvement, in advance of having significant numbers of those resources we will be partnering with several NYC institutions who have demonstrated expertise in K-12 programming. We would be happy to have the next planning meeting with PS/IS 217 within the next 90 days to begin more detailed planning.
Q - Community needs its own environmental consultant, to be paid for by Cornell
An Environmental Management Report should be prepared for this project and be reviewed and concurred by all stakeholders. Should have independent consultant monitor construction (Page 2-3)
A - During the abatement, demolition and excavation of the site, a third party monitor will be appointed and information will be available to the community. As a requirement of the Remedial Action Plan (RAP)/Construction Health and Safety Plan (CHASP) governing hazardous materials, reviewed and approved by NYCDEP, third- party monitoring will be conducted to ensure compliance with these Plans. A P.E.-certified Remedial Closure Report will be prepared at the completion of each phase of the project to document and demonstrate that all remedial activities have been properly implemented.
In 2013, we will establish a Construction Task Force with the community which will receive regular and detailed updates and will ensure an on-going dialogue with the community about environmental concerns and construction generally.
Q - Should commit to security plan to address terrorism concerns (Page 3)
A - All major universities, including Cornell, take security very seriously. Given our existing presence in NYC, we are familiar with some of the challenges of balancing the needs for security, with the desire for an open campus in the City. We have already begun planning and we will work with the appropriate experts and agencies on security issues.
Q - Should use barges. Barging is preferable, could expand to include ferry service and construction of permanent dock; explore ferry service as mitigation for traffic impacts; RIOC completed a ferry study (Page 4)
A - Cornell presented our work to date on barging to the community on 11/26/12. As indicated at that meeting there are several options that look promising and we are continuing the analysis as well as meeting with appropriate agencies to discuss the feasibility of the various options.
While the Cornell project is not dependent on ferry service, we agree that ferry service would be great for the island and therefore would like to work with other owners and stakeholders to achieve this goal.
As we continue to explore barging we will look for opportunities to utilize those facilities for passenger service. Currently our analysis shows that barging requires a set-up very different than passenger-oriented infrastructure, but we will continue to look for synergies.
Q - 50% of materials should be locally sourced (within 100 miles of site) (Page 6)
A - We are committed that our campus will be a minimum of LEED-silver. LEED provides credit for materials sources within a 500-mile radius (which for NYC includes a lot of water!), and all of our past LEED projects have achieved this LEED objective. We typically encourage both architects and contractors to help in achieving this goal – architects by specifying materials that can be supplied locally/regionally, and contractors by including local suppliers in the bid process. To achieve one LEED credit point, 10% (by cost) of the total materials have to be locally sourced and manufactured. To achieve two, 20% is the goal. We typically achieve both points as there is enough regional manufacturing to allow this without cost impact.
Q - Will Cornell be making concrete on site? ( Page 6)
A - Although we are reviewing the possibility, it is unlikely there will be a concrete batch plant on site. Extended permitting periods, environmental impacts (control of truck wash out, noise and dust, etc.) and the delivery of raw materials (gravel, portland cement, chemical additives) are all factors that are significant obstacles to making a plant a reality.
Q - Will Cornell help with the cost of the seawall that we all need to keep the Island intact and safe during storm surges? (Page 7)
A - We will not own nor control any portion of the promenade or seawall. The best protection against storm surges is raising the level of the site, as we are planning to do. To the extent that a barging plan impacts the seawall, we would make any necessary repairs at that location.
Q - Provide pedestrian access to 59th St. bridge (Page 8)
A - We think it is a great idea and are happy to initiate a study to examine the feasibility of pedestrian access to the 59th Street Bridge. However, construction of such a facility would be a significant capital investment beyond the scope of the Cornell campus.
Q - Disabled community is well respected on island and Cornell should make provisions for disabled, e.g. priority on buses (Page 8)
A - The Cornell campus is being designed in recognition of the needs of the disabled community and will be fully accessible.
Q - There would be 1,000+ vehicle trips each day on Main Street during the construction period for Phase 1. (Page 14)
A - The Draft EIS considers a worst-case scenario at the period of most intensive construction activities, and assumes that all materials will be brought in by truck (versus barging or other alternative methods that continue to be studied). With these conservative assumptions, the highest number of trucks in the peak construction period – the third quarter of 2015 – would be 67 per day, and the number of worker vehicles would be approximately 334. The number of trucks and worker vehicles would be less at other periods.
Moreover, not all of these vehicles would necessarily be on Main Street, as many of the workers would park at the Motorgate Garage because there will be only 100 parking spaces available at the Cornell site.
Q - What type of explosive materials will be used and its method of transportation to the Island? Method of handling the excavated soil, the existing ash layer (usually includes high level of metal including mercury), and the dust control? (Page 16)
A - Explosives will not be necessary to complete the rock excavation. All the rock material anticipated on site should be of a type that can be excavated by mechanical means.
Q -How is the helix ramp leading from the bridge to the island going to be improved to handle the huge heavy truck traffic anticipated? What would be the impact if the ramp had to be closed for repairs? (Page 18)
A- No improvements to the helix are proposed as part of the project. As with any transportation facility, including local roads, highways, and bridges, necessary repair would be conducted with the appropriate maintenance and protection of traffic and pedestrian flows, subject to review and approval by the entity having jurisdiction over the facility, which in this case would be RIOC. Cornell will be complying with the reduced load limits on the bridge and helix as approved by DOT.
Q - Why is there no modeling of traffic during AM and PM peak hours in the Study? Will there be traffic jams and backups across the entire bridge, on Vernon Blvd, and especially on Main St in the PM rush (it seems that there will be)? (Page 19)
A - The DEIS includes a detailed traffic impact analysis for the AM, midday, and PM peak hours and provides recommendation on potential mitigation measures where significant adverse traffic impacts were identified. On Roosevelt Island, no significant adverse traffic impacts were identified for Phase 1 and the impacts identified for Phase 2 could be addressed with the installation of traffic signals at two on-island intersections.
Q - Why is there no consideration of Cornell running its own shuttle buses for staff parking at Motorgate during peak hours rather than using overcrowded red buses? (Page 20)
A - The DEIS analysis identified the need to increase Red Bus service during peak construction and in Phase II to address anticipated increase in ridership, the cost of which would be paid for by Cornell.
Q - Construction trucks will be a truck every 8 minutes. (Page 23)
A - During peak construction in the 3rd quarter of 2015 when an average of 67 daily truck deliveries were estimated, it is correct that there would be on average approximately one truck delivery every 8 minutes. However, as shown in Table 20-3 on page 20-12, the average daily truck deliveries during Phase 1 and Phase 2 construction were estimated at 37 and 21, respectively, which would be substantially less than what may be experienced during the peak quarter of construction.
Q- Cornell must contribute to the Public Service Department in order to adequately increase the manpower that will be needed for maintaining security and safety for new residents and its facilities (referring to DEIS 4-4) (Page 24)
A - Cornell will have a security department that will work cooperatively with the Public Service Department and NYPD. As described in the DEIS, the proposed project does not meet the CEQR Technical Manual threshold for an analysis of police and fire protection services.
Q - No hazardous materials should be transported on main street (only barge) (Page 26)
A - To the extent that trucks are used either to bring in hazardous materials (e.g., fuels) or take out hazardous materials (e.g., asbestos removed prior to demolition or petroleum contaminated soil during tank removal or subsequent excavation), it would only be performed in strict accordance with the RAP/CHASP (e.g., covering of trucks containing soil) and applicable regulatory requirements, including those relating to state waste transporter permits and state/federal placarding rules.
Q - Privately Owned Public Spaces generally have 24 hour access – why should the public space on the campus be limited to certain hours? Concerned whether open spaces will be publicly accessible, and whether portion of waterfront connection will be enclosed (Page 37)
A - The public access area hours in the zoning text (open daily from 6am to 10pm between April 15th and October 31st and from 7am to 8pm for the remainder of the year) are the hours that apply to waterfront access areas under Article VI, Chapter 2 and accordingly are proposed for the development site given its proximity to the river on two sides. Hours of operation are included in the Zoning Resolution in virtually all cases where publicly accessible open space is required for development, as opposed to public plazas generating a floor area bonus. The reason for having stated public access hours is that there is a benefit to having hours of operation to control noise and promote a secure campus.
A maximum of 20% of the required open space may be covered, and some of this space could be located within buildings, provided that the space remains open and publicly accessible, and complies with the minimum height and other design requirements applicable to public access areas.
Q - What kind of academic research and what kinds of business will be here? (Page 38)
A - Because this is a tech campus, the research will be around data, software, and related hardware such as robotics and basic electronics. The businesses interested in locating on the campus are ones that will benefit from collaboration with the campus in these areas, either in the tech sector or in related industries.
Q - What is meant by "corporate co-location" use? (Page 39)
A - The first phase of the campus likely will include 100,000 square feet of corporate co- location space. The campus is designed to directly connect academic research with industry. The corporate co-location buildings will provide space for private companies, start-ups, entrepreneurs and other tech- related organizations that want to be located on campus with close access to the Cornell Tech students and faculty. Under our lease with the city, we are required to develop an academic campus including at least 620,000 sf of academic space, which will prevent the site from becoming a business district.


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Materials & Coatings
Producer of Perforated and Expanded Metal Products Opens 18th Service Center
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Saturday, November 1, 2008
McNichols Co., Tampa, FL, opened its newest service center near Kansas City, KS. The newly constructed 24,000-sq.-ft. facility in suburban Lenexa is the firm's 18th service center in North America, and includes 12,000 sq. ft. dedicated to fabrication services—plasma-arc cutting, welding and more. McNichols manufactures perforated and expanded metals, wire cloth and various types of grating and flooring.
McNichols Co.: 913/310-0599; www.mcnichols.com
See also: McNichols Company
Related Enterprise Zones: Materials/Coatings
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Bockrath colon cancer discusses colon cancer information and prevention
live streaming schedule & on demand videos
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