text:
Willkommen, bienvenue, welcome, welkomEdit
Welcome to the Vim Tips wiki! We hope you can help improve the articles by fixing typos, adding comments (at the bottom of each tip page), rewriting tips, joining in discussions, or making other improvements.
Be sure to visit the community portal for information about our site, with links to how to pages.
Keep an eye on recent changes to check progress.
Our policy guidelines may be useful. We'd like you to join the very low-volume mailing list.
Hi Chrisbra, welcome to the Vim Tips wiki! Thanks for your edit to the File:Undo tree.vim.png page. It's always great to see new contributors. This is an automated message; somebody may drop a message for you here in the next day or two with any comments or suggestions, but until then keep up the good work, and don't be afraid to be bold!
Please leave a message on my talk page if I can help with anything. -- JohnBeckett (Talk) 20:51, May 11, 2010
Rollback Edit
Thanks for reverting those recent vandalisms. I just allocated you the rollback right to make that a little easier. After checking the diff and deciding the changes were bad, you can click "rollback" (an extra link next to the most recent edit). That removes all consecutive edits by the same IP or user with a standard edit summary. On the other hand, the fact that you see the rollback link can be a little irritating (and somewhat easy to hit accidentally), so if you don't want it please reply here). JohnBeckett 03:53, November 1, 2011 (UTC)
- Thanks, let me try how I get around with that Chrisbra 06:39, November 1, 2011 (UTC)
Batch rollbackEdit
WOW. Good use of your new rights for this nonsense:
Did you get through all 103 of the edits on the list?
If so, did you find some way to do a "batch rollback", or did you need to do each page manually?
--Fritzophrenic 17:54, November 8, 2011 (UTC)
- I noticed this nonsense, when he made changes to one of the pages, I am watching, so using the rollback permission I got recently, I manually rolled back each change as it happened (well almost...). Still, several clicks were neccessary. Chrisbra 20:03, November 8, 2011 (UTC)
Merging tips Edit
Thanks for merging some old tips (I notice you did that recently and in the past). I think that's one of the most valuable things to do here as it removes obsolete gunk, and reduces the number of tips that need fixing. I'm leaving a note with a suggestion for next time.
It's best to avoid any possible upset to someone who might have created a tip. So I no longer refer to deleting old tips as not useful (with a couple of exceptions for out-of-place material where we don't have an alternative tip with replacement text). Another issue is that we should credit material that is added to a tip (that's desirable, and it's part of the copyright as it is supposed to be possible to work out who-contributed-what from page histories).
Suppose tip 1100 is called "Some old tip" and better material is at tip 1200 which is "Improved tip", but 1100 has some useful info. My procedure:
- Edit 1200 and paste in an exact copy of the 1100 page (including its tip template and all comments) under a new heading like the following, with an edit summary like the following:
- Heading:
==Copy of 1100 [[Some old tip]]==
- Edit summary:
Merge from 1100 [[Some old tip]]
- Heading:
- Edit 1200 again (perhaps immediately after saving above, or in a few weeks time). Do the actual merging (delete the "Copy of" heading, and the tip template for 1100, and old comments and stuff that's not wanted). This is just a standard edit, with an edit summary like "merge".
- Edit 1100 and replace it with a redirect:
- Content:
#REDIRECT [[Improved tip]]==
- Edit summary:
Merge to 1200 [[Improved tip]]
- Content:
If 1100 is actually junk, you might do all the steps above, but end up deleting everything that was copied from 1100. The edit summary would still be as above ("merged") on the basis that all useful material for current Vim is now at 1200 (but there was nothing useful).
The details of the above are not vital, and we worked for years without doing these steps, so any glitches or forgotten steps can be ignored. The rationale is that the above makes it easier to work out what happened at some time in the future. For example, a comment from 1100 might end up as part of 1200. Looking at the history of 1200, someone can determine when the material was added, and there will be a link in the history identifying where the material came from. If wanted, the person could check the history of 1100 and see how that material was originally added to the wiki.
There is one more detail, but I think it's best to leave that to me (that is, ignore the following). Anyone is welcome to do it, but it's routine trivia that is easy for me to do, and I have a script which I run every few months; it tells me if there is any navigation that needs fixing. The detail is that someone has to check "What links here" (in sidebar toolbox) when looking at tip 1100. One thing that will link to the old tip is VimTip1100. That page (for a real example) would be a redirect, and it needs to be changed:
- Old content:
#REDIRECT [[Some old tip]]
- New content:
#REDIRECT [[Improved tip]]
- Edit summary:
Fix redirect for merged tip.
There are sometimes other pages linking to the old tip. If it is in a normal tip, the link should be updated to the new destination. If it is on a user page or a "New tips" page, it should be left unchanged.
Sorry to drop all this here, but I wanted to document what I think is "best practice" somewhere. JohnBeckett (talk) 10:42, August 29, 2012 (UTC)
Try your code firstEdit
You added an example to the Search and replace tip, but I think you did not test your code - that isn't works on my system (tried out on Debian Sid & Win Xp, terminal & GUI, v7.3.547-7) The
:substitute does not executes the second part of the command with the
n flag.
--BimbaLaszlo (talk) 06:12, May 4, 2013 (UTC)
- It works well. The problem is that you do not have a version of Vim that satisfies "With a recent enough Vim". I think it was Chrisbra who created the patch that Bram applied to Vim a few months ago which fixed what you are referring to. I would like to find the patch number because I'm planning to fix Copy search matches to use the much better technique that current Vim offers, and would like to be a bit more precise about which version of Vim is required. JohnBeckett (talk) 06:48, May 4, 2013 (UTC)
- You need at least patch 7.3.627, which makes those things work. I initially created that patch, so that my Colorizer plugin works without creating many undo-states. (commit referencing patch 7.3.627). Chrisbra (talk) 11:01, May 4, 2013 (UTC)


text:
Windows 7 Games | Action & Arcade Games | Sushi To Go Express
Sushi To Go Express Game
One hour or 60 minutes free trial demo version of the game is provided above. There are some games with more than 1 hour (80 minutes) time limit. Windows7Games.com provides virus free games setup files which are placed on secure server. Downloading time of game setup files varies depending up on size and your internet connection speed. Before buy your full version legal copy with various available payment methods you can play free demo of downloadable casual game. You have to purchase activation code or serial key for full version of the game by credit card, Visa Card, Master Card, American Express Card, Discover Card or Via PayPal.
Read Sushi To Go Express Game Features
- Fast-paced gameplay
- Unique upgrades
- Help Tony Tortuga!
- Buy full version of this game for PC!
Minimum System Requirements for Playing Game
- Operating System: Windows XP/Vista/7/8
- Processor: 1.0 GHz
- RAM (Memory): 512
- DirectX Version: 7
- Free Space on Hard Disk: 38 MB
More Information About This PC Game
- Game Size: 25.66 MB
- Date of Release:
- Game Category: Action & Arcade Games

subset: commoncrawl


text:
STAY AHEAD OF THE MARKETAll of our property searches are updated daily with the latest listings, prices and statuses of availability for each home. Begin your Lake Travis home search by using our Property Search Tool, or download our Mobile Property Search App so you can search while on the go. Use our Highland Lakes Property Search Tool to get the latest listings for the homes upstream from Lake Travis. All of our search tools allow you save searches, save favorites, receive email updates about homes you might like and offer the ability to search by map. Be sure to register on either search tool you use to take advantage of all the features they have to offer.
CHOOSE YOUR OWN LAKE TRAVIS REAL ESTATE EXPERTPurchasing a new home, or selling your current home, can be an overwhelming task. Get fast, personalized service, from our Lake Travis Realtors® and not some computer generated match. By using our Agent Search Tool, you can select a highly qualified, service focused real estate professional that can help with all of your Lake Travis home buying and selling needs today!
Located about 12 miles northwest of Austin, the Lake Travis area is surrounded by rolling hills and beautiful lakeside communities Nearby you will find shopping, fine dining, excellent schools, luxurious spas, resorts, golf courses and the new Lakeway Regional Medical Center. Easy access to Lake Travis, Lake Austin and Highland Lakes make this area a highly desired residential spot for those who enjoy a relaxing atmosphere, outdoor activities, nature, canoeing, fishing and boating. Home prices in this area range from $300,000 to $10 Million.
Alta Mira, Aviara, Barton Creek, Bauerie Ranch, Belterra, Bridges at Bear Creek, Brodie Heights, Brodie Springs, Chaparral Park, Circle C Ranch, Courtyard at Gaines Ranch, Covenant Estates, Covered Bridge, Deer Haven, Escondera Condominiums, Estates of Bauerie Ranch, Grananda Hills, Hielscher, Ledge Stone, Lost Creek at Gaines Ranch, Heights at Loma Vista, Maple Run, Meridian, Oak Park, Olympic Heights, Regents Hills, Ridge at Lantana, Sendera, Shadowridge Crossing, Shady Hollow, Sierra Vista, Southland Oaks, Spanish Oaks, Sunset Valley, The Madrones, Travis Country, Travis Country West, Village at Western Oaks, Westcreek, Western Oaks.
"Texas Real Estate Commission Information About Brokerage Services�
"Texas Real Estate Commission Consumer Protection Notice.�


text:
Marine Electronics
Top Product Reviews
Samsung Fast Adaptive Charger Original 2 Pack with 2 Micro USB OR Type C Cables
November 9, 2019
I've ordered these charger cords in the past & have been satisfied with them. I was somewhat disappointed that these cords are not as thick as the cords I've received previously nor as long.
Steve Madden Women's Mid-Length or Maxi Chevron Coat
November 10, 2019
This is the warmest coat I've had in a while! The sleeves have fleece cuffs that are slightly longer than the shell to keep out the cold and wind, and the oversized pockets easily hold gloves, keys, and a wallet.
Winter Gloves Warm Windproof Gloves Waterproof Gloves Touch Screen Gloves
November 9, 2019
After opening the package I didnt think the gloves would even fit but to my surprise they did. I work on a 13 acre ranch, and I know these are not work gloves but they keep my hands warm and they allow me to my job. WILL be purchasing a few more.
Spire By Galaxy Women's Heavyweight Parka Jacket with Faux-Fur Hood
November 9, 2019
For the price it is a decent warm long coat! Wish it had the flannel lining throughout the inside instead of small portion -and rest a silky cold material.
Gucci Guilty Eau de Toilette for Women (1, 1.6, or 2.5 Fl. Oz.)
November 3, 2019
I don't know what this smells like in a Department Store, but this small bottle is one of the best fragrances I have ever bought!! I would love it to be available in larger bottles on Groupon. I can't say what it smells like, but it's yummy!!


text:
Lipscomb Athletics is excited to announce that the official dedication of Smith Stadium will take place on Saturday, April 12 at 3 p.m. or 15 minutes following game one of the Lady Bisons doubleheader with Mercer University.
Game one is set to begin at 1 p.m.
Smith Stadium will honor the families of Michael Smith and son Derek Smith who own Rio Grande Fence Company, one of Nashville's most respected businesses since 1958.
The Smith family has been instrumental in elevating the softball complex into one of collegiate softball's premier facilities.
Besides the construction of a 500-seat stadium, the Smith Family has generously assisted the Lipscomb softball program with a new stadium entrance surrounded by brick columns with flag poles adjoined by Rio Grande fencing, a new padded outfield wall and new backstop padding, a new windscreen that includes extensive branding throughout the park, new in-dugout restrooms for both home and away teams and a new inning by inning LED scoreboard that includes a decorative truss and Lipscomb branding.
"We are so appreciative of the Smith family for their tremendous support for our softball program," Philip Hutcheson, Director of Athletics, said. "The Smiths have been game changers for our Athletic Department and their support will bless our student-athletes for years to come."
With the naming of Smith Stadium the Lipscomb Softball complex will officially be known as Draper Diamond at Smith Stadium.
"We are incredibly grateful for what the Smiths have done," Lipscomb softball coach Kristin Ryman said. "It started a long time ago with what the Drapers gave to our program to allow us to have the ability to build a new field.
"We have one of the best facilities in the conference. I feel like it just keeps getting better and better and that is because of the generosity of first the Drapers and now the Smiths. The Smiths have gone above and beyond."
Ryman points out that the Smiths are fans of the softball program.
"It is fun to work with the Smiths because they are detail people," Ryman said. "They know how to run a business. They run one of the best in Nashville in Rio Grande Fence Co..
"They haven't just given money and been hands off. They have continued to stay involved and that is exciting for me as a coach."


text:
ADEN Flint could be sold to help Swindon Town manager Paolo Di Canio in his January transfer window business.
The Advertiser reported last week that two League Two clubs are interested in signing the imposing centre-back, and Di Canio confirmed after Town's 4-0 defeat of Carlisle on Saturday that he has received offers for the 23-year-old's services.
The Italian did not name the interested sides in question, although the Adver understands they are Port Vale and Bradford, but he did admit that he would consider shipping his defender out if it meant freeing up the funds necessary to extend the loan deals of Chris Martin, Danny Hollands and John Bostock and bring another new face to the club.
With Troy Archibald-Henville set for up to six months on the sidelines, Di Canio would be left with just three regular senior centre-backs – Darren Ward, Joe Devera and Alan McCormack – but he said his hand could be forced due to a lack of spending power at the County Ground.
"He could be the player. Not because I don't like him, because when we talk about him it is not confirmation of the name of the player we have to sacrifice, but it's one that we have received a request from a few clubs ready to spend money that can give me the opportunity," he said.
"He's one of the options. He's probably the main one because there is this opportunity but we will see because I want to keep him. I want to maintain this group. If it's possible I want to bring in another player.
"If we can send out all three players and keep Flint that will be the worst madness situation in the world, especially if there is no financial problem.
"The problem is something that I don't understand or I don't want to understand because I don't want to burn my brain. I want to keep going. I don't want to spend nervous energy thinking about why."
Di Canio also revealed that any potential permanent switch for Paul Caddis to Birmingham in January appears to have fallen through.
A fee was agreed in principle with the Blues, only for the Championship outfit to state that they are unable to complete the deal for the former Town captain this month.
Caddis is now expected to complete his season-long loan at St Andrew's, with rumours of a move to Bristol City believed to be inaccurate, while Adam Rooney will also see out his spell in Wiltshire.
Di Canio said: "This is the problem. We agreed a deal in some way and the amount of money, but at the end we received: 'We can't buy him now'.
"At the moment they say no, and 99 per cent not even for the rest of the transfer market month.
"We have to know he will stay there. We're happy to keep Rooney in here until the end of the season and go through another plan."


text:
Watch Taylor Swift Perform New Tearjerker 'Ronan' at the 'Stand Up 2 Cancer' Telethon
Taylor Swift delivered a heartfelt, heartwrenching performance of her original song, 'Ronan,' at the Stand Up 2 Cancer telethon on Friday night (Sept. 7). Warning: You're going to need tissues for this.
Swift wrote 'Ronan' about a three-year-old boy of the same name ater reading a blog post by his mother, Maya Thompson. Thompson is credited as a co-writer of the song. The actual Ronan passed away after battling neuroblastoma in 2011.
Accompanied only by a guitar and a lone drum, Swift sits on a stool and croons softly, "I remember your bare feet down the hallway / I remember your little laugh / Race cars on the kitchen floor / Plastic dinosaurs / I love you to the moon and back. … Come on baby with me, we're gonna fly away from here / You were my best four years." Swift addressed the death of the tot poignantly and heartbreakingly, singing, "Flowers pile up in the worst way" and describing the painful drive home. While her pitch may not be the best it's ever been in this performance, we're chalking it up to the fact that she was probably struggling not to cry while she sang it. It's simultaneously warm, sentimental and absolutely haunting.
All proceeds of 'Ronan,' which is available on iTunes, will go to fight cancer. Good luck listening to it without crying — we only lasted about 30 seconds before we started lying and saying our eyes were just really, really watery.


text:
(Reuters) - Billionaire investor Carl Icahn is so convinced he was right to sell some of his Netflix Inc stake that he made a big bet - possibly worth hundreds of millions of dollars - with his son Brett, who disagreed with the decision.
Icahn, whose firm acquired Netflix shares for an average price of $58 against their current price at $330, cut his 9.4 percent stake by more than half to 4.5 percent, booking profits of around $800 million, he revealed on Tuesday.
His son Brett Icahn, 34, who came up with the idea to invest in Netflix, and Brett's investment partner David Schechter, said in a statement they believe the streaming video company is still undervalued. They said they did not want to reduce the stake in the company, which produced the Emmy Award-winning drama series "House of Cards."
So Icahn agreed to make up for any lost profits by injecting money into funds run by his son and Schechter if their views are proven right and it turns out he sold the Netflix shares too soon, according to a regulatory filing which details the agreement. If the shares climb further, then Icahn has committed to make "cash or cash equivalents" available to a new fund under Brett Icahn and Schechter's management, called the New Sargon Portfolio, it said.
Carl Icahn didn't return calls seeking comment. Brett Icahn responded to emailed questions by referring to the filing but declined to elaborate. Schechter couldn't be reached for comment.
The father-son agreement is one of the more unusual bets seen in the investment world. It exposes the dynamic between the corporate raider-turned-activist investor and a son who has been slowly cutting his teeth in money management.
It is unclear whether Carl Icahn needed the agreement of his son and Schechter to reduce the stake and the bet was the result, or whether it was a much more informal arrangement.
The payment to New Sargon will be based on a "notional" position in Netflix - as if the stake had not been reduced.
For example, if the Netflix shares, which Icahn sold at between $304.23 and $341.44 to reap a profit of about $800 million, continue to climb to say $500 then Icahn would have missed out on a much bigger potential gain of about $1.3 billion. He would pay the Sargon portfolio a large part of the difference - through a complex calculation that includes assumptions, a hurdle, and is also related to the shares' value at the end of March this year. The agreement expires in August 2016.
Netflix shares have dropped about 15 percent from an all-time high of $389.16 hit on Tuesday, before Carl Icahn did the bulk of his selling. They closed on Wednesday at $330.24.
It is unclear whether Brett Icahn and Schechter would personally take a slice of any payment from the older Icahn or just reinvest the money in the fund.
If Carl Icahn's decision to sell is proven to be the right investment call and Netflix's shares fall, both father and son will see their profits from the investment pared, given they still own 2.67 million shares, or a 4.5 percent stake. There will be no additional penalty for his son's funds if the share price falls below the Icahn selling price.
Such a decline in Netflix's shares would validate Carl Icahn's status as one of the world's savviest investors and dealmakers. In the filing, he said in reference to the Netflix investment that as a "hardened veteran of seven bear markets I have learned that when you are lucky and/or smart enough to have made a total return of 457 percent in only 14 months it is time to take some of the chips off the table."
The younger Icahn and Schechter, however, said Netflix "remains significantly undervalued" and "one of the great consumer bargains of our time."
The Sargon Portfolio, which the younger Icahn and Schechter co-manage and Carl Icahn supervises, has generated 37 percent annualized returns since its inception on April 1, 2010, through September 30, 2013, and currently manages in excess of $4.8 billion for Icahn Enterprises and Carl Icahn's own capital. Icahn Enterprises has assets of approximately $29 billion.
Carl Icahn has also credited his son for his $2 billion investment in Apple Inc, though Icahn himself has been communicating with Apple CEO Tim Cook. Icahn tweeted on Wednesday that he "just sent a letter to Tim Cook. Full letter will be disclosed on my website, the Shareholders' Square Table, which will be launched tomorrow."
Reporting by Jennifer Ablan in New York; Editing by David Gaffen, Paritosh Bansal, Martin Howell and Lisa Shumaker


text:
First Drive: 2013 Lamborghini Aventador LP 700-4 Roadster
Let's play a game of pretend. Let's pretend that the dude who's able to drop a half-mill-something for the top-of-the-range, screw-sanity Lamborghini Aventador Roadster actually cares about how it drives -- about throttle tip-in, the ministrations of the differential, how strenuously the back end wiggles under brain-pan-smushing decelerations. Let's pretend that he won't drop $445,300 (and maybe $70K in options) and head straight for South Beach to see how many halter-top-wearing hotties he can cram into the leather passenger seat before Miami's vice squad takes notice.
Lamborghini launched the topless version of the Aventador in -- claro que si! -- South Beach. Italians have never been afraid to embrace cliche, especially when it's working for them, and under the vast umbrella of the VW Group, Lamborghini is doing quite well indeed, thank you. The headed-for-pasture Gallardo was its bestselling model ever, and more than 1200 examples of the Aventador can be found bedazzling locals from Boston to Beijing.
Fortunately, before crabbing along in auto mode on bumper-to-booty-packed Ocean Drive, we opened up the Aventador's 691 hp at Homestead-Miami Speedway. And? Well, in the grand tradition of monster Lambo flagships, the Roadster is kind of a hot mess. And in the continuing tradition of said monster flagships, we're kind of all right with that.
The Roadster sees a few changed mechanics from the original coupe, including cylinder deactivation and an auto stop/start system on the 6.5-liter V-12. (Oh, the gas savings! Eh...) Those changes are being ported over to the coupe as well, so the internals are the exact same.
The top of the carbon-fiber monocoque tub was guillotined away, and extra reinforcements were added to the sills to compensate for the loss of stiffness. The result is an additional 110 pounds.
Unfortunately, the springs and dampers have also been tweaked to give a softer ride on both models -- a result, Lambo execs say, of customer input. (Read: complaints from butt-sore spouses.) This makes the ride more palatable on questionable asphalt and/or Ocean Drive, but on sweepers with heavy cornering loads, the suspension goes squishy, even when riding on optional Pirelli P Zero Corsa tires. The Roadster's wheels, by the way, are 20 inches up front, 21 rear, so as to look even more awesome around South Beach.
As expected, the car is steroidal and maniacal, excellent qualities when your hands are totally open on the steering wheel, your gas foot sucked to the floor and the right paddle triggered at every redline. Top down, it's your own personal wind tunnel, flipping eyelids inside out. Sixty-two mph comes in three seconds, top speed is 217 mph, even with the top off.
Nuance just ain't its thing. That massive mid-mounted engine has enough torque to topple oak trees (509 lb-ft at 5500 rpm), but using it in any measured way is a curious business. In Sport and Corsa modes, the gas pedal has two essential characters: off and blunderbuss blast. There is very little in between. It's impervious to moderation. Try easing into the throttle, and you'll be met with a short, lumpy pause -- hello? -- before a concussive slap of power causes the entire frame to unsettle. Lamborghini execs aren't unaware, and the software may see future tweaks. Add this to the tendency for this big, wide car to understeer, and big, slow corners become a lesson in Taoist patience. Or you can get a little sneaky.
Sport mode oddly allows more slip than Corsa, channeling 90 percent of torque bias to the rear wheels, versus only 80 in track mode. We found that the fastest way to conquer slow corners was to stick to Sport, get all braking done extra early -- and the brakes are phenomenal -- then come completely off both pedals as you round a big turn. At the apex, goose the gas to induce that sledgehammer torque, setting up just enough slip to get the nose pointed the right way early. Then, slam it.
Along the way, there will be lurches, bucking, and very wonderful exclamations from the twelve-cylinder perched behind your noggin. The entire operation isn't always pretty, but it is guaranteed hoot-worthy. After all, if you were looking for al fresco delights married to ideal dynamics, you'd be rereading the review of the McLaren MP4-12C Spider, which is like a too-perfect dinner guest compared with the Lambo's lampshade-on-the-head buffoonery.
Besides, the Aventador's primary purpose, the place where it lives, is to entertain. And that it does. Start with the design. It is unquestionably an Aventador -- wider than a barn, shorter than a Hobbit, edges sharp enough to give paper cuts. Scissors doors, but of course. The reality-defying, Barbie-esque proportions are compounded when the roof is off. The car is simply bad-ass in real life.
The rear engine hood has been reworked. Stacked glass plates cover the engine, with a spine running down the center. It is a show stopper. But retaining the peek-a-boo view to the engine meant that the top could not be an automatic. Instead of a folding hard top or canvas covering, we get two carbon-fiber pieces (each weighing 13.2 pounds) which snap into place. In other words, it is human operated, just like a Camaro T-top of yore.
Snapping the roof on or off isn't an easy-peasy process. But it's child's play compared with storing the two pieces in the front trunk, where they're ensconced in an overly elaborate shelving system. Think of a real-life game of Tetris, with you blind folded and a sizable crowd gathered to watch.
We see a lot of future divorces beginning here. "You bought a half million dollar car and you can't even figure out how to get the roof back on?"
No worries there. The newly single owner can simply return to South Beach in his shiny Aventador and begin the wooing process anew. The Roadster is made for that.
2013 Lamborghini Aventador LP700-4 Roadster
Price: $445,300/$482,820 (base/as tested)
Engine: 6.5-liter DOHC 48-valve V-12
Horsepower: 691 hp @ 8250 rp
Torque: 509 lb-ft @ 5500 rpm
Transmission: 7-speed auto-clutch manual
Drive: All-wheel
L x W x H:188.2 x 79.9 x 44.7 in
Headroom: 36.6 in (top up)
Legroom: 36.8 in
Curb Weight: 4180 lb (est. )
Fuel economy: 11/18 mpg (city/highway, est.)


text:
Zebra Z4M ribbons
Thermal transfer ribbons for Zebra Z4M printers
FeedYourZebra supplies only genuine Zebra thermal transfer ribbons for Zebra Z4M and Zebra Z4M Plus industrial label printers.
Zebra Z4M and Z4M Plus thermal transfer ribbons are designed specifically for use with Genuine Zebra labels in Zebra Z4M printers.
Using genuine Zebra thermal transfer ribbons helps you achieve the best print results possible and all at great prices.
All our prices include free delivery.
Zebra thermal transfer ribbons are available for Zebra Z4M in the following formulations to perfectly match your label printing application.
Zebra 2300 standard wax thermal transfer ribbons provide very good print quality on most uncoated and coated paper facestocks. It provides good print quality on normal and rotated barcodes at speeds of up to 254mm per second. Its low print energy requirements for image transfer and its superior backcoating make this a superb pure wax ribbon choice for all Zebra thermal transfer printers. Suggested applications for Zebra 2300 standard wax thermal transfer ribbons are general purpose labelling, shipping and receiving and inventory tracking. You can find labels for the Zebra Z4M printer here.
Zebra 2100 high performance wax thermal wax thermal transfer ribbons are resin enhance and offer superior abrasion resistance when compared to conventional was ribbon products. The Zebra 2100 thermal transfer ribbon provides excellent print quality on normal and rotated barcodes on coated and uncoated thermal transfer labels and tags, as well as many many synthetic label materials. Its low print energy requirements for image transfer make it the ideal choice for extremely high print speeds up to 304.8mm per second. You can find labels for the Zebra Z4M printer here.
Zebra 3200 premium wax / resin thermal transfer ribbon is a special ink formulation for use with all Zebra thermal transfer printers. The Zebra 3200 thermal transfer ribbon provides outstanding print quality on a wide range of label materials and provides smear and scratch resistance on Zebra paper and synthetic label materials. In addition, it offers good resistance against many everyday chemicals resulting in staying power and durability in harsh environments. Suggested applications for Zebra 3200 thermal transfer ribbons are outdoor product labelling and retail shelf-edge labelling. You can find labels for the Zebra Z4M printer here.
Zebra 3400 high performance wax / resin thermal transfer ribbon offers excellent print quality on a wide range of coated and uncoated paper labels and many matt synthetic labels materials. The ribbon excels when rotated barcodes are required. This high performance ribbon also provides good abrasion resistance and is competitively priced, offering an economical solution to many industrial and retail labelling applications. Suggested applications for the Zebra 3400 thermal transfer ribbons are shelf-edge label and tags, box and pallet labelling, inventory labels, labels exposed to steam, alkali or acid solutions and industrial labels with medium life expectancy. You can find labels for the Zebra Z4M printer here.
Zebra 5095 high performance resin thermal transfer ribbons provide images resistant to most harsh environments (smearing, moisture, abrasion, extreme temperature and chemicals) when printed with our Zebra synthetic labels and tags. The low energy requirements for this ribbon will allow for excellent print quality even when very small fonts are required and high print speeds are possible. Suggested applications for Zebra 5095 thermal transfer ribbons are chemical container labelling, automotive labels, industrial rating plates. You can find labels for the Zebra Z4M printer here.
Zebra 4800 performance resin thermal transfer ribbons offer exceptional abrasion and solvent resistance on a wide variety of label materials, while still providing excellent edge definition. This ribbon is an excellent choice for printing dense barcodes and high resolution graphics. Its unique resin base provides excellent resistance to outdoor elements and many chemical solvents. Suggested applications for Zebra 4800 thermal transfer ribbons are steel mill labels, automotive labels, labels exposed to harsh outdoor environments. You can find labels for the Zebra Z4M printer here.
If you are looking for genuine Zebra direct thermal labels, Zebra thermal transfer labels, Zebra thermal transfer ribbons or Zebra replacement thermal printheads, then you'e found the right place and FeedYourZebra can help.
With over 10 years experience, we are a leading Zebra authorised reseller, supplying genuine Zebra products throughout the UK and EU. We have the widest stock of Zebra labels, ribbons and printheads available for next day delivery. All items are shipped free of charge - even to the EU (for a list of the countries we supply see here).
We supply direct thermal and thermal transfer labels for Zebra desktop printers. Zebra desktop range consists of LP2824, TLP2824, LP2844, TLP2844, GC420d, GC420t, GK420d, GK420t, GX420d, GX420t, GK430t, GC420d, GC420t and GT800 printers. Labels for the Zebra desktop printers are supplied on 25mm cores and have a maximum outside diameter of 5" (or 125mm). They are not interchangeable with labels for Zebra industrial printers due to the different size core and small maximum capacity.
With the exception of the Zebra LP2824 and TLP2824, the maximum label width available is 102mm. The LP2824 and TLP2824 has a maximum label width of 57mm.
Zebra thermal transfer ribbons are available for the Zebra desktop range, however, you should note that certain models are direct thermal only printers - so don't have the capability for using thermal transfer ribbons - these are LP2824, LP2844, GK420d, GX420d, GC420d printers.
FeedYourZebra supplies labels for Zebra mid-range, industrial and high performance printers. Labels for these printers are supplied on 76mm cores and have a maximum outside diameter (roll size) of 8" (or 203mm).
Different models in the industrial and high performance range are available - some of these models have differing maximum print widths - and so the maximum width of label that can be used varies across the ranges.


text:
Every year, thousands of kids travel to Stratford to visit the Children's Garbage Museum, but time may be running out.
"We've been here since 1993. What we do is, we teach people how to take care of their environment by recycling and by thinking before they throw something in the trash," said Paul Nonnenmacher, Director of Public Affairs at the CT Resources Recovery Authority.
One attraction at the garbage museum is a trash-a-saurus, a one-ton dinosaur made from trash thrown in dumpsters and landfills.
"It depicts 2,000 pounds, which is how much trash each person makes of trash in Connecticut every year," Education Supervisor Sotoria Montanari said.
At the museum, visitors learn the importance of recycling. They also get a bird's eye view of the Connecticut Resources Recovery Authority's recycling center. That's where your recyclables go when they leave your house.
"For many years, this museum has been funded by money we get from recyclables that are brought to the adjacent recycling center," said Nonnenmacher.
But the museum has a major problem. Those contracts end on June 30 and the recycling center will make less money on new contracts that go into effect after the 30th. There will be no money left to run the museum.
"The situation is pretty grim. We're down three runs in the bottom of the 8th and the Yankees have Rivera warming up in the bullpen," said Nonnenmacher.
Until then, the museum is working to get the word out about its dire situation, hoping someone steps in to help so it can continue to education young people.
"We hope the impact will be that it empowers them to go home and actually make a difference, to teach their parents to recycle more to think about reusing items," said Montanari.


text:
A spring can occur when an underground flow of water stagnates and is compressed or heated. The water needs a release. If the water finds "weak earth" and pushes through to the surface, it will be released. This creates a spring: a pool of mineral water.
Magic, technically Espiritus - the energy of magic, also flows through the astreal world like water. There are place where pressure builds even in the fluid astreal world. It finds the point of greatest weakness, usually the barrier between the realms. The energy flows forth out of the Astreal into the world. In most cases, this makes a place attuned to a higher energy, making it unique or empowered. In the case of "negative energies" which are chaotic and destructive, pooling has other consequences. While a little negative Espiritus can be healthy, too much is disruptive. Where it pools "melts" the reality there, changing it to match its form. This Espiritus becomes material. The material form is a HellPit.
HellPits vary in size, from anywhere from an arm span to two man's heights across in a roughly roundish shape. The sides are always sharp, as if a hole has been punched in the ground. As to depth, it is hard to say. Things that enter a HellPit tend not to leave (or if they do, they do so in a very different form). A HellPit is not technically a pit, but a pool of magically charged chaos. The pool's surface is always a bit from the surface - from a hand span to an arm's length below the edge. Even major extractions can only lower the level of the pool for a time (thus attempts to drain pools always fail). It is always bubbling too, giving off a smell like a lighting bolt has struck.
The pit itself is a hazard, but the pooled liquid, that is the true danger. It is Hell's Blood.
Hell's Blood is the thick syrupy liquid that "pools" in HellPits. It is a shocking green that glows with its own soft light. Its smell is the smell of burning things, things burned by lightning. It is charged with the potential of change.
This magical change can be dangerous.
Change "builds up" and randomly leap away like lightning to the ground, striking some point near the HellPit. Some strikes are near. Some are far, like the edge of a great forest. Anything touched by this "change bolt" is changed, and usually not for the better. The thing is changed to a darker, more dangerous, more destructive form. Trees become animated and blood thirsty, rabbits begin to hunt, wolves become giant wargs with spikes on their spine, bears become giant monsters shooting lightning from their claws, no changes are ever exactly alike.
And woe be it to the thing that falls into the pit. If it emerges, it becomes a creatures of nightmare. No longer recognizable for what it was, it is truly a monster.
Sometimes, and this be legend, things of true Evil or Chaos emerge from the pits full cloth, escaping from their realms through the astreal and ending up in the material world.
Places around HellPits are assumed to be cursed, dammed, or shunned. The number of "monsters" in the vicinity of a HellPit is daunting. The occasional "other thing" that is in the area is what people fear.
Those who practice magic and do not mind the touch of Evil or Chaos, will utilize the ectoplasm in their magics. Any magic of change (and any magic really, as it changes reality) is empowered and amplified by use of the Hell's Blood. If one is not too concerned with safety or possible changes, using the Hell's Blood directly (burning it in a brazer or keeping it a chalice and using it as a foci) is quite potent.
Now, if there are enough HellPits in an area, people might be able to learn how to use their power. If one is not too picky, the powers can be used to restore lost limbs.
The most common way to use these power, safely, is to keep the Hell's Blood in a "Reliquary", a glass cylinder topped with gold/silver/bronze caps. (A bone of some animal is in the Hell's Blood). Not only will this create a powerful light source, but it will generate a manna every scene or impulse (depends on the Hell's Blood or the Bone used).
Hell's Blood that has been "purified" and most of its magic removed, still has uses. If kept in a Reliquary like item, it is still a strong ever burning light source.
Variations on Reliquaries can allow "power" to empower magic items or other things.


text:
Mike Tyson can still throw punches, but he doesn't throw stones.
The former heavyweight champ, who won big laughs with his cameo in "The Hangover," said he would not have had a problem working with Mel Gibson had the "Braveheart" star appeared in the sequel.
"I'm not going to ever in my life point my finger at anyone," Tyson told the New York Post. "I don't live in a glass house. None of us do. I work with anybody, as long as they're respectful."
Gibson, whose once-stratospheric career has been brought down by scandal surrounding his ugly breakup with babymama Oksana Grigorieva, had hoped to get back into the game with a funny turn as a Bangkok tattoo artist in"The Hangover 2." But a cast revolt, reportedly led by Zach Galifianakis, got Gibson nixed and replaced by Liam Neeson.
Tyson, who served prison time for rape and has fared worse against his own demons than he ever did in the ring, had sympathy for Gibson.
"We all have that guy -- a Mel Gibson -- in us. We just don't want people to be exposed to it. Maybe he needs to go get help. We all need help, and need someone to talk to. I'm not against him, but I'm not for him."
Selected Reading: New York Post, Popeater, IMDb.


text:
Easy Muffins Recipes
View All | View Summaries
Mango Stilton Cheese Muffins
06.29.11 by Jackie
Making savory muffins is one of the easiest fancy, light accompaniments you could prepare. The batter can even be prepared in advance. This time around, I flavored the muffins with mild stilton cheese, dried mango and fresh ginger.
I prepared a full platter of mini muffins and served them with a salad of mixed greens and another platter of rolled smoked salmon (cold sliced meat would work fine as well), crème fraîche and slices of lemons. The weather is getting warmer, so a light lunch along with sweet treats and fresh cold drinks was really satisfying.
Full Recipe...


text: CONTRIBUTE TO THE CAUSE Please consider donating to support the next generation of innovators and leaders in Africa. Your donation will help empower youth to make an impact in their communities for years to come. Donate Today! OVERVIEW & PROGRAMS Today, despite greater global interconnectivity and opportunity than ever before, the creativity and agency of our youth in Africa is sidelined. Young people have bright ideas about the problems that face their communities, but those ideas are seldom expressed or heard. As a result, youth miss the opportunity to test their ideas for improving their societies, or even realize the value in their ideas. This culture of learned helplessness cuts the countries off from generations of good ideas and stunts the growth of creativity in talented young people. GMin believes that young people everywhere should have the opportunity to "learn to make and make to learn". GMin therefore provides design workshops, seed funding, mentorship, physical spaces and opportunities to go through rapid prototyping that enable young people to learn through solving actual challenges in their local communities. MISSION Global Minimum fosters a generation of young innovators and leaders in Africa who tackle challenges affecting their communities through critical thinking and hands-on learning. LOCATIONS Sierra Leone Kenya South Africa Cultural and environmental differences are taken into account with each program and therefore no two programs/projects are identical. Our country teams are dedicated to creating the best environment for our participants to thrive. INSPIRATIONAL INNOVATORS Hundreds of students in Sierra Leone, Kenya, and South Africa have participated in GMin's programs over the past four years. Their remarkable stories continue to inspire others to create a culture of innovation in their communities. Kelvin Doe Mercy Sigey Tom Osborn Luthando Dyasi Want To Read Other Student Stories? Teams of young innovators like Kelvin Doe from Sierra Leone, Nicola Jacobs from Cape Town, and Sophia Seketo from Kenya identify problems in their communities and develop prototypes that aim to solve them. Take some time to read more of the inspiring stories of students who, along with their teams, set out to create impactful change in their communities, by developing innovative solutions.Inspiring Students Focus Areas Enabling Youth Helping youth identify local problems and come up with local solutions. Innovation and Entrepreneurship Providing the opportunities and educational outlets for youth to learn. Building Community Involving the entire community for sustainable change. CONTRIBUTE TO THE CAUSE As we are committed to empowering others, we have been fortunate to have received financial support from people across the world. Please consider donating today to support the next generation of innovators. Your donation will help us to continue to empower talented individuals to make an impact in their communities for years to come. Donate Today! gminHome05.08.2014


text:
discover RELAIS DU CHATEAU formerly known as CASA ILLICA
like a small luxury boutique hotel near a medieval castle
a best kept travel secret halfway between Parma and Piacenza in the lands of Giuseppe Verdi
1 hour from Milan and 1 hour 30 from Bologna
… in the footsteps of the greatest successes "Madame Butterfly", "La Bohème", "Tosca" …
From an altitude of 200 meters, the RELAIS DU CHATEAU • CASA ILLICA, located two steps away from the medieval castle of Castell'Arquato, one of "The most beautiful villages of Italy", is overlooking the verdant rolling hills meld into rich flowing vineyards. A nineteenth-century villa in Liberty style where Luigi Illica, the librettist of Giacomo Puccini and Pietro Mascagni was born in 1857 and lived almost until his death.
This little gem, hidden in the historical center of Castell'Arquato is the only place where to spend one or more nights in the tranquility of an exclusive residence with a top quality accommodation and a multilingual host to satisfy all your requests with great attention.


text:
Game Servers (2)
Setup Guides for Game Servers
Information (2)
Company Info.
Linux VPS Hosting (2)
General Information for Linux VPS Hosting
Our Network? (2)
Get test ips and more
Web Hosting (4)
General Information for Web Hosting
Most Popular Articles
Cloudflare - For Your Site
CloudFlare Via Their Website If you would like to setup CloudFlare manually using the CloudFlare...How to Use RDP - Best Remote Desktop for Windows, Mac, & Linux
How to Use RDP - Best Remote Desktop for Windows, Mac, & Linux Remote desktop is an...Nameservers
Cyclone Servers Nameservers NS1.CYCLONESERVERS.NET (22.214.171.124)NS2.CYCLONESERVERS.NET...Installing MySQL On CentOS
MySQL is an open-source relational database that is free and widely used. It is a good choice if...HOW DO I LOG INTO MY VPS AS ROOT VIA SSH?
To log into your VPS from a Windows machine: You will need a program that supports SSH...
Powered by WHMCompleteSolution


text:
Obituary index
Elizabeth A. "Betty" McKinlay
Send a link to a friend
[June 20, 2014]
Elizabeth A. "Betty" McKinlay, 83, of Lincoln passed away
on Tuesday, June 17, 2014 at The Christian Village Nursing Home in
Sunday from 5:00 p.m. until 7:00 p.m. at the Peasley
Funeral Home.
Rosary Service: Sunday at 4:30 p.m. at the
funeral home
Monday at 11:00 a.m. at Holy Family Catholic Church
Funeral home: Peasley Funeral Home, Lincoln
Elizabeth A. "Betty" McKinlay, 83, of Lincoln passed
away on Tuesday, June 17, 2014 at The Christian
Village Nursing Home in Lincoln.
A Mass of Christian Burial will be held on Monday,
June 23, 2014 at 11:00 a.m. at Holy Family Catholic
Church with Rev. Jeffrey G. Laible officiating.
Visitation will be held on Sunday, June 22, from
5:00 p.m. until 7:00 p.m. at the Peasley Funeral
A Rosary Service will be held at 4:30 p.m. prior to
the visitation.
Burial will be in Holy Cross Cemetery in Lincoln.
Elizabeth Ann McKinlay was born on April 25, 1931 in
Creston, Iowa the daughter of Floyd and Gertrude
Schmitt Derrickson. She was united in marriage for
sixty-two year to Don E. McKinlay on January 12,
1952 in Lincoln. He survives.
Also surviving are her children: Kathleen Jacques,
Jane (Dennis) Carroll, Nancy (Dennis) Netoff, Kent
(Rhonda) McKinlay, Mary (Tim) Hallissey, Mark
(Angie) McKinlay, Karen McKinlay. Thirteen
grandchildren and Six great grandchildren. Two
sister: Marilyn Taylor and Diana Powell.
She was preceded in death by two brothers: William
"Bill" Derrickson, Jesse Derrickson.
Betty graduated from Lincoln Community High School.
She retired from State Bank of Lincoln. She had
previously worked for Representative Jack Lauer in
his Lincoln office.
She was a member of Holy Family Catholic Church.
Memorials may be made to American Cancer Society.
Click here to send a note of condolence to the McKinlay family.
Did you know.....
...You can send a
condolence note to families via email?
Fricke-Calvert-Schrader, Peasley,
Quiram-Peasley and
Holland Barry & Bennett funeral homes have this option
Click on the name of the appropriate
funeral home (in the line above) and insert the family name to
send a note.
< Obituary index
Back to top


text: Fear Before (formerly known as Fear Before the March of Flames) is an experimental rock band that resides in Aurora, Colorado. As stated on their Alternative Press podcast, their name originates from a Colorado newspaper headline of local forest fires titled "The Fear Before The March of Flames." They released their debut album Odd How People Shake in 2003 with a re-release in January 2004, second album Art Damage in September 2004, third album The Always Open Mouth in September 2006, and fourth album Fear Before in October 2008.


text:
Strategic planning, team training, and belief in employees have Absolute Dimensions machining its way to success.
The timing was right when Mike Rickords and his son-in-law, Stephen Brittain, decided to turn their dream of owning their own machine shop into reality. Mike had decades of experience working for a large aerospace manufacturer, and Stephen had held various positions from CNC operator to large assembly program manager at a small firm. So in 2003, when Mike heard that he might be laid-off, they both got serious about the idea of using their combined experience to start their own business.
Building the business plan
While they were putting together a business plan, they reached out to the Kansas Small Business Development Center (KSBDC) at Wichita State University. The KSBDC helped them create a more robust business plan to present to a bank for financing. "After 10 banks turned us down, Garden Plain State Bank approved a SBA guarantee 7(a) loan to finance one water-jet machine and some operating capital," said Stephen. Then, on March 19, 2004, Absolute Dimensions, LLC opened its doors for business.
By 2008, the business was doubling its revenue every six months, and they needed another machine to keep up with demand. One week after they bought a new horizontal CNC machine, the strike at Boeing in Seattle hit the market hard. "Our financing and nerves got tight in those days. Luckily, we had some receivables and cash on hand to help us through those lean months" said Stephen. "Business was slow and we were concerned about our keeping our employees on the payroll, so we participated in the Kansas Shared Work program," he added.
In 2009, Absolute Dimensions, LLC was able to obtain a SBA 506 Recovery Act zero-interest loan to help through the difficult time. They also kept in touch with the KSBDC for guidance on strategic planning, and even had all five of their office staff attend their workshops. The strategic planning process helped them diversify their product and service capabilities to include composite materials. They also added new customers outside the aerospace industry. Absolute Dimensions, LLC is now using their machining equipment to produce parts for a truck manufacturer, a company that makes signs, and they even make custom metallic inlays for tile.
By 2012, Absolute Dimensions, LLC, was growing to the point where they needed to consolidate their financing at a larger bank that had the capacity to service their needs. Today, the company's 24 employees are trying to keep up with demand, and using every inch of available space in their facility.
Advice to other small business
When asked for their words of wisdom to other small business owners, Steven and his wife Miranda, who manages the office, said it is vital to manage the growth of your business. "You can grow too fast and put your business at risk", said Stephen. "Save money when you have it because your cash flow can create constraints", Miranda added. They both believe it's important to reach out to organizations like the Kansas Small Business Development Center for expert advice on business planning. They gave a lot of credit to the KSBDC and the SBA for helping them navigate through the turbulent times.
The future looks bright for Absolute Dimensions, LLC. If things keep up, they may be looking for a new building and more automation to meet the growing demand.
Originally published at http://www.sba.gov/about-offices-content/2/3117/success-stories/753832
Additional video footage of Absolute Dimensions can be found here.
Alan Badgley, consultant with the KSBDC at WSU assisted Absolute Dimensions. Alan has expertise in strategic planning, specialty finance, and training. Alan can be reached at email@example.com or 316-978-3193316-978-3193.


text: Rory Brady was Ballycraig's golden boy, the local lad who moved to America and became a professional hockey player. But he broke his promise to Erin O'Brien-and never went back for her. Now Erin has moved on, and Rory must race the clock to prove to her that the man she fell in love with is still there. But can happy-go-lucky Erin risk it all and give another chance to the man who broke her heart?


text:
Deryck Whibley Removes Ex-Wife Avril Lavigne's Last Nameby Mandi Salerno | PopCrush
Sum 41 lead Deryck Whibley has been dealing with a lot of big life changes. Most recently, he's finally received a legal name change, dropping the last name Lavigne that he acquired when he married ex-wife Avril Lavigne.
The 34-year-old rocker married the 'Hello Kitty' star in 2006 and officially changed his name to Deryck Lavigne Whibley. The forward-thinking couple only lasted for a few years before they filed for divorce in 2009, but it wasn't until this past November that Deryck went through with the paperwork to drop his last association with the blonde singer. The change was approved this past Thursday, June 12, according to TMZ.
Deryck has also been struggling with alcoholism and just last month spent time in the hospital due to medical issues resulting from the addiction. On June 6 he posted an update on his health to his website, sharing, "My days are quite full, but I work on getting better every day. I have doctor check ups often, and I've had so many needle pricks in the past few months, that all the veins in my arms are dead. … The progress may seem slow to some people but I'm getting better all the time and I love being sober."
On a happier note, he added, "There's a lot of writing going on as well and I have a few exciting things for a new record already. I can't wait to get back out there and see you all again."
We're wishing you the very best on your recovery, Deryck!


text:
BALTIMORE (AP) — Shackleford won the Preakness on Saturday, holding off a late charge from Animal Kingdom to win as a 12-1 underdog.
The victory was redemption for Shackleford, who finished fourth behind Kentucky Derby-winner Animal Kingdom after leading for much of that race.
It also meant there would be no Triple Crown try at the Belmont Stakes in three weeks.
In the Preakness, Shackleford battled for the lead from the outset. He trailed Flashpoint in the early going, then took the lead and wouldn't relinquish it despite a hard charge from Animal Kingdom.
Ridden by Jesus Lopez Castanon and trained by Dale Romans, Shackleford won by three-quarters of a length in 1:56.21.
Castanon has never before won a Triple Crown race or even Breeders' Cup race. His father was a trainer in Mexico.
Animal Kingdom was the morning-line 2-1 favorite at Pimlico and was bidding to become the first Triple Crown winner since Affirmed in 1978. The colt came from well behind to make a charge, but appeared to make the move too late. He paid $4.20 and $3.60.
Astrology took third and paid $8.00.
Dialed In finished fourth, followed by Dance City, Mucho Macho Man, King Congie, Mr. Commons, Isn't He Perfect, Concealed Identity, Norman Asbjornson, Sway Away, Midnight Interlude and Flashpoint.


text:
New Planet Born in Milky Way?
Astronomers say they may have spotted a possible planet in the dramatic and violent process of being born, an event that may shed light on how large, gaseous planets come into being. Gautam Naik reports on Lunch Break. Photo: AFP/European Southern Observatory.
This transcript has been automatically generated and may not be 100% accurate.
... I ... on the ball ... in a larger gains you that are spotted by astronomers in the Milky way ... Delta night Kansas amazing story James is right now from our London bureau ... Dow from a shrinking deal in the Milky way hot tell how many know that this might actually be a planet ... write what were these the astronomers have found is a in addition distant part of the galaxy about ... three hundred and fifty light years from ... Earth ... in the Milky way ... there is a very um stall ... and around this young still is a ... disc comprised of gas and dust ... and this disc which they believe ... is the likely place for the ... birth of new planets ... they seem to discover that I mean ... write to all ... that could be a planet that is in the very early stages of being formed ... this is important because although some scientists have pinpointed what might be ... slightly older planets ... this perhaps is the first time they found something ... actually being born in distiller womb ... and what was the technology gal cannot tell us what we're talking about Star Wars here like in a galaxy far far away ... I've that was the technology to allow them to view this happening with their special type of telescope ... well it's true that ... that's right that is a telescope in the app to come and desert in Chile certificate sitting very high up above sea level ... Annie gets a very clear the of the heavens ... what they did was they found that this disk of gas and dust ... around this young star in the Milky way Galaxy ... had a bit of both ... anomaly that there was some disturbance in it ... so they tried to take a picture using this telescope and an infrared camera off ... the latest evidence of what they discovered was ... that that tiny gold ... appeared to be because of the radiation intimated that kind of heat that that seem to be generating ... a new body that has been for ... the way this would happen is tiny bits of debris in this gas disc what kind of cool events can keep the money each other and colliding ... and get bigger and bigger under the influence of gravity but most likely collapse ... and form of that and that's what they believed it discovered ... and right now they think that planning could be about the Siamese the size of Jupiter or potentially bigger ... that's right idea covered estimates is that it's you know roughly the size of Jupiter which is in the justice but of course in our own solar system ... of but it could be two of three times larger ... and ... it's ... not of much else is known about this body but ... you know it's in it it's essentially FB just in the Stetler womb it's gonna take tens of thousands of years for this to go up and become a full fledged planet like a ... and in the next coming years and decades of these astronomers of a new study ... this lavender and trying to understand better how which was formed ... because the question of how planets both of our solar system and the rest of the universe ... come to be is the ... enduring mystery in in cosmology ... are right that say no we have that technology can even watch at this stage captain night more on that that gift a digital network on all our platforms


text:
Month: February 2011
Willamette Valley Oregon for Valentine's Day Weekend
What could be better than a glass of Pinot Noir wine coupled with Pinot Noir brownies! Monks Gate Vineyard near Carlton, Oregon tempts with this offering Valentine's Day weekend. Linda bakes these irresistible treats herself and will offer them to visitors of the vineyard/tasting room on Saturday, February 12 and Sunday, February 13. (Tasting fee applies).
Monks Gate is one of dozens of wineries in the Valley planning special events during Valentine's Day weekend. The theme at Coelho Winery in Amity will be "The Perfect Aphrodisiac," with the staff offering a selection of wines paired with "sweet and savory aphrodisiacs." On Sunday, February 13 at 3 p.m., Vintage Voices, a jazz ensemble, will perform classic love songs in the tasting room. (Reservations requested, charity donation to YCAP.)
Get ready for a fun and eventful weekend in the Willamette Valley this Valentine's Day weekend. We invite you to make the R. R. Thompson House in Carlton your home base during a weekend of exploration.


text:
Rubeosis iridis is a reddish discoloration in the colored part
of the eye (iris) caused by the growth of abnormal vessels. It usually results
from severe diabetes and may progress to neovascular glaucoma, a severe and
often painful type of glaucoma.
Last Revised:
March 22, 2011
Healthwise Staff
Medical Review:
Adam Husney, MD - Family Medicine & Carol L. Karp, MD - Ophthalmology & Christopher J. Rudnisky, MD, MPH, FRCSC - Ophthalmology
This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
To learn more visit Healthwise.org
© 1995-2012 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.


text:
Please enter the text you see above to unblock the
email address. If you cannot read the text, you can reset
it and try different text.
Skip To Navigation
Skip To Content
Alberta.ca > Agriculture and Forestry
> General Store
> Wood BioMass Listings
Please let us know what you think
Phone the Ag-Info Centre, toll-free in Alberta at 310-FARM (3276), for agricultural and forestry information.
© 1995 - 2019 Government of Alberta Copyright and Disclaimer


text:
Nutrition Facts
Ingredients and Preparation
Tip: Use extra lean ground beef to lower the fat content in this meat loaf.
- Mix all ingredients together.
- Place in 1-pound loaf pan (preferably a pan with a drip rack) and bake covered at 350°F for 50 minutes.
- Uncover pan and continue baking for 12 minutes.


text:
Additional information
|1.5 kg
Mother of the bride outfit from the Irresistible Collection.
Irresistible IR4008 in Rose
Irresistible is one of the newer brands on the Mother of the Bride/Groom scene, bringing quite a unique blend of sophistication and glamour with just a touch of power dressing for the big occasion.
The designs help to build the confidence that, in turn, builds pride. The ruffled and ruched fabrics are flattering and allow the wearer to relax knowing that, whether sitting or standing the dress will keep the secrets of the years modestly covered. Uncompromising colours and patterns add to the palette that creates an ideal canvass on which to accessorise.


text:
Lining Things Up
I've been a little too busy to blog lately, but I have a free moment and thought I'd give an update. I'm sure most of you saw the article I wrote the other day on the Vernon Wells situation. Toronto has set a "flexible deadline" of about a month or so for negotiating a contract extension with Wells. After that? Toronto could a)look into trading Wells or, b) keep him and just hold off on discussions until during the spring or during the year. If they can't reach an agreement, it doesn't necessarily mean the Jays will trade Wells, but the club will surely at least entertain offers.
So now we wait. Toronto could still look at some of the free agents out there, but in the current market, it might make more sense to explore trades. The Jays could offer Dustin McGowan or some other young pitchers. I wouldn't be surprised to hear Adam Lind or Reed Johnson's names in trade rumors either. And teams will definitely inquire about Alex Rios, but it seems very unlikely he'd be dealt. The Jays needs at least one starter. If Wells is traded, Toronto would also need an outfielder — corner outfielder would work fine because Rios can play center. Dodgers and Mets have been rumored teams.
On another subject, it's getting to the point where we can start guessing what Toronto's lineup could be. The only spots really in question seem to be the No. 2, Nos. 6-8 spots.
Gregg Zaun might be a good fit for the two hole because of his ability to get on base and he is a switch hitter. He doesn't move that great around the bases, though, so maybe Lyle Overbay — the only other lefty in the order — might be a better fit. Aaron Hill's style of hitting might be best suited for the No. 2 spot, too, though. Rios has hit there in the past as well. For argument's sake, I'll put Zaun in the No. 2 spot and then the other slots fill out themselves.
So here is one possible lineup:
1. LF Reed Johnson, R
2. C Gregg Zaun, S
3. CF Vernon Wells, R
4. DH Frank Thomas, R
5. 3B Troy Glaus, R
6. 1B Lyle Overbay, L
7. RF Alex Rios, R
8. 2B Aaron Hill, R
9. SS Royce Clayton, R
If Rios picks up where he left off last season, Wells-Thomas-Glaus-Overbay-Rios is quite an impressive row of hitters. What are some lineup thoughts that you all have? Get those posts going…
29 Comments
At the beginning of the off-season, I was all for trading Vernon Wells, because I was fed up with the way he seemed to disappoint in the clutch.
However, after the Frank Thomas signing, I reversed my thought process. It became clear that Vernon Wells was a perfect fit for the order.
I would really like to keep Wells but in reality, he may cost too much for the Blue Jays to resign at the end of the year, and if he doesn't sign an extension, I think that he should be traded.
I would be thrilled if Ricciardi could manage to fill out our rotation without giving up any of our outfielders (including Lind) in trades. I don't mind trading any of the young pitchers, because I am not certain that any of them have particularly bright futures.
I love Zaun's OBP and switch-hitting ability in the two-hole, not to mention overbay, but I think Rios should bat second.
If Rios can bat around .300 (of which there is a very good chance) his OBP will be high enough, and more importantly he will benefit from all those extra fastballs hitting in front of Vernon Wells more than Zaun would. Rios' speed looks good there too!
The patient veterans (Zaun, Overbay, Glaus and Thomas) are better off down the lineup with more RBI opportunities albeit with less protection.
I think that Overbay and Glaus should be switched in positions. Overbay had a great year at five-spot last year, and that way there is only two righties in a row in the power part of the lineup. If that were the case, then rios would have to bat after glaus to a)scare pitchers into giving him pitches and B) knock him in considering his OBP.
Second, I see that the White Sox may be looking to trade Tom Garland for some younger talent, and I am wondering if thats a possibility at all. His contract is hefty, 22 million over two years, but maybe worth it?
I like Hill at second because he sees lots of pitches. Plus, he better speed than Zaun. Rios is more valuable at the 7.
Why would Jays need a major league outfielder in a trade back from Wells? They look like they have one in Lind already. He can take left and Johnson can slide into centrefield. Jays seem to be deepest in outfield prospects as well.
I say one major-league arm, one pitching stud prospect, and maybe relief or SS prospect for Wells.
I agree with Zaun second. OBP is definitely key in the early slots. You don't need to be able to run fast when the guys after you are hitting homers, which is definitely how this team is built. Plus, if Zaun's power numbers last year in his limited plate time scale up to full-time this year, that's going to be even more runs scored for Johnson.
If you put Rios in front of Overbay then Rios can use his speed to score from first on a double. If Overbay makes an out, then Rios can think about stealing second, since Hill is more of a singles hitter and you're not going to take the bat out of his hands the way you would if he stole in front of one of your big hitters.
i personally like
I know that overbay before glaus is a bit unrealistic but glaus hasn't really impressed me. Overbay had a great year last year and that with no one else hitting behind him. If glaus is hitting behind him he will get more better pitches which he could easily hit for doubles scoring in wells, rios or johnson and thomas if he gets on base. Glaus could then bring in overbay. I think that zaun is too slow to be second and he isn't a 2nd place hitter.
In regards to the wells situation i say sign him. If you can't come to an agreement then trade him. This would be the best time to do so. I like the trade with the angels or the mets. Mets would be better for us since they aren't in american league and we won't have to face wells. If wells gets traded then probably overbay would move to 3rd to fill his spot and then …
Personally I like Alex Rios batting second. When he was in the second hole last season he seemed to produce a little better. Greg Zaun has a fantastic OBP but I like him lower in the order. My lineup would look like this
With this lineup everyone has a bit of protection. Rios will see alot of good pitches ahead of Wells while Overbay and Zaun give great protection to the middle of the order. And if Wells does get traded I wouldn't mind seeing Rios hit in the three hole. He has speed and his power is starting to come around.
You want to split up Overbay and Zaun as the only left-handed/switch hitters in the order.
My opinion would be
As it was already mentioned, you want to split the lefties/switch hitters. You don't want to have your left handers back to back in the order, as it helps to separate to get the pitcher off a groove.
To me, I hate the idea of trading Wells, he is the main key guy of this ball team right now. I know we now have a lot of great players, but Wells is too good to lose. I think there is too much more to come from him. However, if he doesn't sign an extension, then by all means, he should go. Although his gap in center will be hard to fill, we have the backup to make a decent replacment.
Still need that starter though
Putting Overbay up second would work too. His OBP was .370 last year.
My opinion would be..
I wouldn't put Thomas at clean up just yet, let him prove himself first and putting Glaus and Thomas back to back you get back to back power and with Wells infront and Overbay behind you have potentially the best line-up in the majors.
Here is my early prediction for the 25-man roster come spring training (and lineup)- barring a Vernon Wells trade.
1)Reed Johnson, LF
2)Alex Rios, RF
3)Vernon Wells, CF
4)Frank Thomas, DH
5)Lyle Overbay, 1B
6)Troy Glaus, 3B
7)Marcus Giles, 2B
8)Gregg Zaun, C
9)Aaron Hill, SS
1) Roy Halladay
2) A.J. Burnett
3) Gustavo Chacin
4) Mark Redman
5) Paul Byrd
1)B.J. Ryan
2)Brandon League
3)Jason Frasor
4)Jeremy Accardo
5)Scott Downs
6)Brian Tallet
C Toby Hall
C/1B Jason Phillips
IF Royce Clayton
IF Jason Smith
OF Matt Stairs
To LA: Prospect for Toby Hall
To CLE: Shaun Marcum + John McDonald for Paul Byrd
Not to be rude but how the **** did marcus giles get here. Also I don't think that the jays should sign redman. THey should go after weaver, suppan or mulder (although he might also get overpaid). BUT FIRST PRIORITY IS SIGNING WELLS.
The Braves decided not to offer Giles a contract making him a free agent as of 12/12/06. To be honest I'm not to high on Giles. He is average at best defensively and his offensive numbers have dropped in three straight seasons. Aaron Hill is going to be a very good 2nd baseman so I feel moving him away from the position would just hinder his development. Also, there would be no need to trade for Toby Hall because he also became a free agent today. I also feel the Jays need to resign Wells. When you have a franchise athlete you need to treat him well and keep him around. These types of players don't come around very often. There are alot of new free agent on the market as of today including a few good pitchers. Joel Piniero has had a couple of tough years but at only 28 years old he still has alot of upside. I also wouldn't mind seeing the Jays go after Suppan a little more aggresivly and maybe even Jeff Weaver. I know Weaver is about as inconsistent as you can get but he is a high risk- high reward type of player. Mark Redman is an option but if you are going to go after that type of player I feel you should probably give one of your youngsters a shot at making the club.
I'm a beleiver of things happening for a reason. The Jays not signing Meche or Lilly could turn out to be a good thing. They would have been overpaid and we can now do things with our leftover money that may not have been possible before. Hopefully Wells can be brought back for 3-5 more years as we have a very solid core of players that we can build around for a few more years. If we can aquire one more pitcher it would be desirable. If not then its going to be a big risk going into next season with what we have. But with all risks there are rewards. If McGowan can get going and slot into that 3rd spot, with his stuff I think he would be a better option than either Lilly or Meche. Marcum in my opinion is a capable 5th starter. He showed us last year that he can command his fastball slider and changeup. Its just a matter of consistancy, if he can go out there and spot those 3 pitches on a regular basis he will be effective. As it sits right now we will have to rely on someone from the group of finge players to step up, Fransico Rosario, Dustin McGowan, Shaun Marcum, Casey Janssen, Ty Tabenheim, or maybe even Davis Romero. As they will make the difference of this team being contenders or average.
I will bet money that our opening day lineup will look like this, barring injuries or trades.
Clayton/Smith (whoever shows up at spring training)
I have a feeling Hill is going to have a great year. No doubt in my mind he is capable of hitting .310 with 10 HR's.
I kind of wish we could have kept Lilly, however his price is too high. But Chacin has a good chance of getting that third spot, and Marcum and McGowan did show that they can have what it takes, its just a matter of how long will it take. Aside from that, we still don't have any idea how the talks with Wells are going, keeping him, in my opinion, is the most important thing right now.
The middle infield still looks a bit foggy, even though we know for sure that Hill has second base to his own. However, how much do we play Clayton/MacDonald/Smith at SS. Overall I think Smith would work out best defensively, so I think he will edge out the others to be the primary starter there.
Marcus Giles?????? Where on earth would anyone get the idea that the Jays would look to sign him? Hello?? Hill IS the starting 2B, no doubt about it now. Once Wells is determined (signed or not) PITCHING will be addressed.
I'm going with the same as Jordan on this one. I agree it would be nice to have Zaun a little lower in the order, but unless Adams or Smith pull of a minor miracle by earning a starting middle infield job AND prove that he can hit (not very likely), or Lind blows everyone away at Spring Training to earn a starting job over Johnson, Rios or Thomas (REALLY not likely) you have to have have a lefty somewhere other than just 8 and 9.
I see why some of you would like to have Glaus hit clean-up and Thomas in 5 but with Overbay (the double machine) in 6 you can't have the Big Hurt (emphasis on "big") lumbering in front of him. Glaus moves a little faster and can score from second or maybe first on an Overbay double. Thomas can't.
Catalanotto was a good number 2 hitter, right? Compare Overbay's stats to Cat's. OBP is very similar and AVG and SLG are higher. Maybe Overbay doesn't have as much speed, but when you hit a double you don't need to steal second.
I am assuming that Wells stays and Johnson is traded in a package for pitching help.
Rios RH
Lind LH
Wells RH
Thomas RH
Glaus RH
Overbay LF (switches with Glaus against lefties)
Hill RH
Zaun SH
Clayton RH
I am assuming that Wells stays and Johnson is traded in a package for pitching help.
Rios RH
Lind LH
Wells RH
Thomas RH
Glaus RH
Overbay LH (switches with Glaus against lefties)
Hill RH
Zaun SH
Clayton RH
It seems that since McDonald was resigned, there is hardly any chance that Marcus Giles will play for the Jays.
You have convinced me that we are better off staying with the stuff we have than going after a second baseman whose team just dumped for unknown reasons.
What do you think about the Wells offer today?
I like the offer. It puts Wells in a class with many of the great in the game. i feel it is about time wells was mentioned in the same sentance as Arod, Soriano and so on. He's one of the best in the game. I also feel it will make a big difference with the way some of the free agents look at Toronto. If they are willing to pay the money to keep Wells around they are obviously committed to winning. That could be the difference between getting a good pitcher and losing one. Maybe Suppan or one of the other good pitchers left out there will consider Toronto as a more viable option because they are showiwng that commitment.
i agree with thumbing my way. V-Dub is a superstar, when all this trade talk was going i was ready to start rooting for the **** bosox or yanks, thank god i dont have to. on another note, MARCUS GILES IS NOT A GOOD PLAYER. JP knows his stuff, any of the three guys platooning at short is a thousand times better defensively than the weak giles, not to mention that Aaron Hill is 4 years younger, hits for a higher average, strikes out less, and is also a much better defender than giles. giles has a little bit more power, but hes a free swinger, we have enough of those already, glaus, thomas, wells. we need more patient hitters like gregg zaun, and i think aaron hill will develop into one of those players. Keep up the good work Jordan!
According to Foxsports.com's Ken Rosenthal, Wells is "close" to signing the seven year deal worth 126 million. It will include no trade protection and an opt out clause after year three or four. he will still be paid 5.6 million next year.
now that is a relief. glad to have wells locked up through '14
It's a lot of money for sure but salaries are only going to go up. In 7 years it might seem as good a deal as 5.6 does right now.
I think paulmartin has a good lineup there. Assuming of course Johnson is traded (which would not make me happy) and Lind is ready.
I really don't like trading Johnson. You need a guy like him at the top of your order. He sees alot of pitches, gets on base and has decent speed. His fielding is exceptional out in Left. That is where we would miss him the most Lind is a great hitter, but Johnson really solidifys our outfeild. As much as I like how Lind can hit, we NEED pitching, and we also have Travis Snider coming up who is comparable to Lind (corner outfeilder with a great bat). So to me one of them could become expendable in return for some good pitching. I think we go after a pitcher with a reptuation, someone who we know will come in and win 15 games for us. Offer them Lind, and a pitching prospect such as Rosario, or Janssen.
But good job on the jays for going after Wells, we can find a way to fill our holes without creating anotherone if we traded him.
Unless something goes terribly wrong looks like he will be a bird for a few more years.
9.Clayton(as it stands now, hopefully we get someone better.)
I even think Overbay might even bat 4th just for the sake of having a left hander in the top of the line up.
1.Roy Halladay
2.A.J. Burnett
3.Gustavo Chacin
4.Mark Redman
5.Jeff Suppan
I think the key for the jays this offseason to sign redman and suppan and not trade rios. If they do sign both of those pitchers i believe they stand a great chance of making to the playoffs.


text:
Decision Making
People who have followed this blog over the last years know my passion for understanding of how consumers make decision. That's why it's nice to see that Stuart Elliott from the New York Times shows interest and respect for some of the work that I am part. Read his comments in today's New York Times.


text:
Lakeview's Neighborhood Bar
Reopened with a fresh new look & new staff as of June 2013—
Burke's has changed the menu to a more pub friendly Fare. Our chef has placed an emphasis on Scratch made comfort food & our large house "sammich" potions.
We have added 8 new 50" Plasma TV's in the bar area to watch every hometown game in style. Our patio is a relaxing oasis in the busy city.
with 12 Taps with Chicago local craft beers & imported selections, & 100 different bottles, we have strived to make the new look Burke's Lakeview's premier neighborhood pub—Jim Burke, Owner


text:
Welcome to Watch List, where we identify five things on TV to watch while you sit at home and try to make sense of the "Lost" finale. I can't believe the whole show took place in the imagination of an eight-year-old boy! What's that? That's not how it ended? Well, it SHOULD have ended that way. LET'S GO!
24 (FINALE) – 8:00PM (FOX) This is it for Jack Bauer. Well, kinda. He's coming back in a movie written by Billy Ray (Shattered Glass), and I daresay that movie will melt your face off. But this is the last time you'll see Jack's mug grace a small screen series. Obviously, he won't die. But surely he'll blow some stuff up, kill lots of people, and hook a guy's nipples up to a pair of jumper cables. Just for old time's sake. Maybe you think "24" is absurd. Maybe you think it's a dated leftover from the Dubya administration. Whatever you think of "24," I will tell you this: There has never been, and may never again be, a more INTENSE show on network television. Think about some of the "action" shows you saw as a kid. What did "Simon and Simon" do every episode? Do you even remember? Didn't they drive a truck around and maybe get into a five-second bar fight? Those days are thankfully over. "24" was the first show on TV to match R-rated action movies in pacing and graphic violence. That will be its ultimate legacy, and it's not such a bad one. ANTICIPATION: BLOOD!
THE BACHELORETTE (PREMIERE) – 8:00PM (ABC) Time for the female twist on "The Bachelor" that doesn't quite work because it's a female twist on "The Bachelor." I dunno. Far more fun to watch women fight over a guy than to watch guys fight over a girl. Anyway, your lucky gal this season is Ali Fedotowsky, who I bet makes one hell of a pierogi. ANTICIPATION: HOT AND POLISH!
CHUCK – 8:00PM (NBC) It's the two-hour season finale, titled "Chuck Vs. The Subway." How dare he fight a corporate sponsor like that! ANTICIPATION: FIVE DOLLAR BEATDOWN!
INTERVENTION – 9:00PM (A&E) A gymnast becomes an addict. What's the average intake of a gymnast alcoholic? Half a beer a day? Three drops of vodka? One lick of the side of a wine bottle and our girl is a TRAIN WRECK. ANTICIPATION: UNEVEN BROADS!
TRUE LIFE: RESIST THE POWER – SAUDI ARABIA – 10:00PM (MTV) Young Saudis tell stories about rebelling against their own oppressive government. Wait a second. This sounds compelling and important. What's it doing on MTV? It's a little known fact that MTV's True Life series is perhaps one of the finest journalistic shows on TV right now. Except for that one where the dude got calf implants. That was just stupid. ANTICIPATION: CALLING CHUCK D!


text:
The Speed Readers?
...okay the name is a work in progress, but the idea is solid.
So some of you might already know about this but I would like to start a TSG book club. The basic idea is we have a month to read the assigned book then after that time we meet together, possibly through skype, and talk about it.
I have a few books in mind and was thinking about a science fiction/fantasy theme at least to start.
Let me know what you guys think or if you have any book that might be good.


text:
Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00155350
Recruitment Status : Unknown
Verified August 2005 by National Taiwan University Hospital.
Recruitment status was: Recruiting
First Posted : September 12, 2005
Last Update Posted : February 27, 2006
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Coronary Atherosclerosis Inflammation Coronary Heart Disease
|Drug: pioglitazone
|Phase 4
Background: Type 2 diabetes and its antecedent, metabolic syndrome, are important risk factors for premature and accelerated atherosclerotic cardiovascular diseases. However, glycemic control by provision of endogenous or exogenous insulin induced only modest and not statistically significant reduction of the risk of myocardial infarction. We and other investigators have demonstrated that the use of insulin sensitizer, thiazolidinediones, resulted in favorable antiatherosclerotic effects in patients with type 2 diabetes or non-diabetic metabolic syndrome. It has become increasingly clear that morbidity and mortality associated with coronary artery disease (CAD) are often associated with lesions that are not obstructive but prone to rupture, the so-called vulnerable plaques. Conventional coronary angiography is not suitable for identifying vulnerable plaques. They may be detected by intravascular ultrasound (IVUS) and recently developed high-resolution 16-slice multi-detector computed tomography (MDCT). Nevertheless, whether this modality could be used as a guide for optimizing medical treatment of CAD has never been explored in the medical literature. In this study, we will evaluate the efficacy of pharmacological therapy targeted to reduce insulin resistance on the progression and compositional change of non-obstructive coronary atherosclerotic plaques and coronary calcification by serial IVUS/MDCT follow-up in patients with type 2 diabetes or non-diabetic metabolic syndrome during a 2-year period.
Methods and Expected Results: Patients aged ≥18 years conformed to the diagnosis of type 2 diabetes or metabolic syndrome criteria in ATP III and with objective evidence of myocardial ischemia will undergo EBCT, MDCT coronary angiography, percutaneous coronary angiography and intervention if appropriate, and IVUS study if non-obstructive coronary plaques are identified in the MDCT examination. Patients deemed eligible (with one or more ≥ 20% and < 70% stenosis in at least one coronary artery) will then be randomly assigned in a 1:1 ratio to receive pioglitazone (30 mg/d) or placebo in an open-label fashion. Patients with type 2 diabetes assigned to the placebo group are not allowed to be treated with any insulin sensitizer. The target for glycemic control in patients with type 2 diabetes in both groups is reduction of HbA1c to ≤ 7.0%. A total of 120 patients are planned to be included, and the follow-up period is 2 years. To assess the progression of coronary atherosclerosis, MDCT coronary angiography/scanning will be performed at baseline and 3, 6, 12, and 24 months of follow-up. Follow-up coronary angiography and intravascular ultrasound study will be performed at 6 months if patients agree. Blood samples will also be obtained at baseline and 3, 6, 12, and 24 months of follow-up for the measurement of various conventional and novel coronary risk factors. We also obtain DNA specimen from blood drawn at baseline for genotyping. The primary end-points include changes from baseline in total plaque volume, plaque characteristics (as determined by CT-density values and other morphological features), and total coronary calcium score. The secondary end-points include percent change from baseline in calcium volume score in each coronary artery, percent change from baseline in plasma glucose/insulin homeostatic parameters and various risk markers, and the occurrence of a composite of major cardiovascular events (death from any cause, non-fatal myocardial infarction, stroke, and target vessel revascularization).
Clinical Significance: This is the first human study to assess the antiatherosclerotic effects of insulin sensitizer by directly visualizing the atherosclerotic plaques of the whole coronary trees. It will provide us great insights regarding the evolution of coronary plaques and techniques of measuring the total vulnerability burden of the coronary arteries.
|Study Type :
|Interventional (Clinical Trial)
|Enrollment :
|120 participants
|Intervention Model:
|Parallel Assignment
|Primary Purpose:
|Official Title:
|Treatment of Coronary Atherosclerosis and Calcification by Insulin Sensitizers in Insulin-Resistant Patients: Evaluated by EBCT, 16-Slice MDCT Coronary Angiography/Scanning, and Intravascular Ultrasound
|Study Start Date :
|November 2004
|Study Completion Date :
|December 2007
- changes from baseline in total plaque volume, plaque characteristics (as determined by computed tomography [CT]-density values and other morphological features), and total coronary calcium score
- percent change from baseline in calcium volume score in each coronary artery
- percent change from baseline in plasma glucose/insulin homeostatic parameters and various risk markers
- and the occurrence of a composite of major cardiovascular events
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Age ≥ 18 years and the presence of type 2 diabetes mellitus or metabolic syndrome, not currently treated by thiazolidinediones. Diagnosis of metabolic syndrome is determined by criteria defined by the National Cholesterol Education Program Adult Treatment Panel III, modified to use World Health Organization (WHO) proposed waist circumference cut-points for Asians. Therefore, this requires subjects to have three or more of the following criteria:
- waist circumference of > 90 cm in men and > 80 cm in women;
- serum triglycerides of >= 150 mg/dl;
- high-density lipoprotein-cholesterol (HDL-C) levels of < 40 mg/dl in men and < 50 mg/dl in women;
- impaired fasting glucose of 110 to 125 mg/dl; or
- blood pressure of >= 130/85 mmHg or treated hypertension.
- Patients with objective documentation of myocardial ischemia undergoing percutaneous coronary angiography and the coronary arteriogram showing one or more ≥ 20% and < 70% stenosis, which will be left untreated at physician's discretion, in at least one coronary artery
- The baseline MDCT coronary angiogram revealing one or more discernible plaque(s) untreated by stenting in at least one coronary artery
- Ability to perform all tasks related to glycemic control and risk factor management
- Written informed consent signed
Exclusion Criteria:
- Class III or IV heart failure
- Creatinine > 2.0 mg/dl
- Hepatic disease (ALT > 3 times the upper limit of normal)
- Poorly controlled diabetes mellitus (hemoglobin A1c [HbA1c] > 13%)
- Fasting triglycerides > 1000 mg/dl in the presence of moderate glycemic control (HbA1c < 9.0%)
- Non-cardiac illness expected to limit survival to less than two years
- Current alcohol or drug abuse
- Chronic steroid use judged to interfere with the control of diabetes, exceeding 10 mg
- Unable to understand or cooperate with protocol requirements
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00155350
|Contact: Tzung-Dau Wang, MD, PhD
|886-2-2312-3456 ext 5632
|Division of Cardiology, Department of Internal Medicine and Department of Medical Imaging, National Taiwan University Hospital
|Taipei, Taiwan, 100
|Contact: Tzung-Dau Wang, MD, PhD 886-2-2312-3456 ext 5632 email@example.com
|Principal Investigator: Tzung-Dau Wang, MD, PhD
|Sub-Investigator: Wen-Jeng Lee, MD
|Principal Investigator:
|Tzung-Dau Wang, MD, PhD
|National Taiwan University Hospital
|ClinicalTrials.gov Identifier:
|NCT00155350 History of Changes
|Other Study ID Numbers:
|First Posted:
|September 12, 2005 Key Record Dates
|Last Update Posted:
|February 27, 2006
|Last Verified:
|August 2005
Coronary calcification
Plaque vulnerability
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Pathologic Processes
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases
Insulin, Globin Zinc
Hypoglycemic Agents
Physiological Effects of Drugs