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Two new review studies evaluating the safety of the pain-relieving medications selective cyclooxygenase 2 (COX-2) inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) find increased cardiovascular and kidney risks. The studies and an accompanying editorial were posted online today by JAMA because of the public health implications of the findings. The articles will appear in the October 4 print issue of JAMA.
"It is estimated that more than 30 million people worldwide take nonsteroidal anti-inflammatory drugs (NSAIDs) daily for treatment of pain and inflammation," according to background information provided in one of the articles. Adverse effects of some conventional NSAIDs include toxic gastrointestinal (GI) effects, as well as adverse renal (kidney) effects. "Overall, an estimated 2.5 million individuals in the United States annually experience adverse renal effects caused by use of NSAIDs," the authors write. "With decreased risk of adverse GI effects, a class of drugs that selectively inhibits COX-2 enzyme was introduced for analgesia (pain relief) and the treatment of arthritis." According to the authors, the adverse renal effects of selective COX-2 inhibition are unclear. Evidence is accumulating on the potential class effect of COX-2 inhibitors on cardiovascular risk. Two COX-2 inhibitors have already been withdrawn from the market: rofecoxib (marketed as Vioxx) and valdecoxib (marketed as Bextra).
Jingjing Zhang, M.D., Ph.D., from Brigham and Women's Hospital and Harvard Medical School, Boston, and colleagues evaluated the adverse risks of renal events and arrhythmia (disturbance of the normal heart rhythm) events in patients prescribed COX-2 inhibitors from a systematic review of the medical literature to determine if these negative side-effects involve every drug in this class.
"In this comprehensive meta-analysis of 114 randomized trials of COX-2 inhibitors comprised of 116,094 participants, rofecoxib uniquely increased risks of renal events (peripheral edema, renal dysfunction, hypertension) and arrhythmia events, with apparent adverse effects by the end of year 2000 and 2004, respectively," the researchers write. "However, the results did not show adverse effects of other COX-2 inhibitors on renal events and arrhythmia, indicating no overall evidence for a COX-2 inhibitor class effect."
In conclusion, the authors write: "Notably for policy and clinical decision making, our results also suggest that a time-cumulative meta-analytic approach for examining available trial safety data would have helped clarify apparently adverse effects several years earlier than the current report. The knowledge of all potential adverse effects is important and indeed time-sensitive, for physicians and patients both need complete information about risks and benefits to properly use COX-2 inhibitors and other clinical treatments." They continue, "future drug safety monitoring of emerging clinical treatments may benefit from continuous cumulative meta-analytic aggregation of safety data for all drug-approval applications and experimental agents." (JAMA. 2006; 296:doi:10.1001/jama.296.13.jrv60015.
Editor's Note: Corresponding author Mr. Ding was supported by a grant from the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) and by an institutional training grant from the National Cancer Institute, National Institutes of Health. Dr. Song was supported by grants from the NIDDK, National Institutes of Health. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
In a related study, Patricia McGettigan, M.B.B.S., B.Pharm., F.R.A.C.P., Ph.D., and David Henry, M.B., Ch.B., F.R.C.P., from The University of Newcastle, New South Wales, Australia, conducted a meta-analysis of the observational studies in the medical literature to compare the risks of serious cardiovascular events (predominantly, myocardial infarction [heart attack]) with individual NSAIDs and cyclooxygenase 2 inhibitors (COX-2).
In background information, the authors write that interest in the cardiovascular effects of the relatively selective inhibitors of COX-2 has been intense. Although rofecoxib was withdrawn from world markets, celecoxib (marketed as Celebrex) "continues to be widely used, despite meta-analyses of randomized controlled trials showing an increased risk of myocardial infarction." The authors add, "attention has turned to the cardiovascular safety of the older non-selective non-steroidal anti-inflammatory drugs (NSAIDs). These agents are used extensively and some are available in many countries without prescription."
The authors based their analysis on 17 case-control analyses that included 86,193 cases with cardiovascular events and over 500,000 controls, and six cohort analyses that included 75,520 users of selective COX-2 inhibitors, 375,619 users of nonselective NSAIDs, and nearly 600,000 unexposed participants.
"A dose-related risk was evident with rofecoxib (relative risk 1.33 with 25 milligrams or less per day and 2.19 with more than 25 mg/day)," the authors report. "The risk was elevated during the first month of treatment. Celecoxib was not associated with an elevated risk of vascular occlusion. Among older non-selective drugs, diclofenac had the highest risk with a summary relative risk of 1.40. The other drugs had summary relative risks close to one: naproxen, 0.97; piroxicam, 1.06; and ibuprofen 1.07." The authors state that this review "contradicts claims of a 'protective' effect of naproxen and raises serious questions about the safety of diclofenac ģ"
"In conclusion, controlled data from observational and randomized studies confirm a dose-related risk of cardiovascular events with selective COX-2 inhibitors. The observational data indicate that the risk increases early in treatment. An older NSAID, diclofenac, seems to share this risk and, unlike celecoxib, it appears to be harmful at commonly used doses. We believe there are grounds for reviewing its regulatory status." (JAMA. 2006; 296: doi:10.1001/JAMA.296.13.jrv60011.
Funding for this review was provided through project grants from the National Health and Medical Research Council of Australia and the National Heart Foundation Australia. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
Editorial: The Seduction of Common Sense In an accompanying editorial, David J. Graham, M.D., M.P.H., from Silver Spring, MD writes, "in this issue of JAMA, two systematic reviews [by Zhang et al and by McGettigan and Henry] provide clarity on a topic that has been dominated more by disinformation than reason." He also discusses the findings of these two new studies and places them in context of other reports on risks associated with COX-2 inhibitors and other NSAIDS.
Dr. Graham writes, "What does this all mean? First, rofecoxib increases the risk of acute MI at low and high doses. ģ There is no initial 18-month period of immunity from risk. Celecoxib also increases risk at doses higher than 200 mg/d; at lower doses, the potential risk is less clear. Several other NSAIDs increase risk, including the COX-2 selective NSAIDs diclofenac and meloxicam, and the non-selective NSAID indomethacin and probably ibuprofen. Meta-analyses of randomized clinical trials and observational studies agree that naproxen is neutral for MI risk."
Dr. Graham also mentions that another COX-2 inhibitor NSAID, etoricoxib (which is not approved for use in the United States), recently was reported to have a risk of thrombotic cardiovascular events similar to diclofenac, with the implication that etoricoxib is safe from a cardiovascular perspective. However, he points out that "etoricoxib was compared with diclofenac, a drug shown to substantially increase the risk of acute MI" in another previous study and in the meta-analysis by McGettigan and Henry.
Dr. Graham concludes, "if the lessons of recent history have been learned, the FDA's concerns will now be squarely focused on patient safety rather than corporate profitability, and, ultimately, common sense will prevail." (JAMA. 2006; 296:doi.10.1001/JAMA.296.13.jed60058). Editor's Note: Dr. Graham reported no financial conflicts of interest, but reported that he was subpoenaed as a federal government expert by plaintiffs, for the purpose of providing testimony (in May 2006) that may be used in a number of Vioxx-related lawsuits, and reported that he received no compensation for this activity, other than his federal salary.
Dr. Graham is an employee of the U.S. Food and Drug Administration. This editorial was Dr. Graham as an officially approved outside activity in his private capacity and not as a Food and Drug Administration employee. The views expressed in this Editorial are the author's own, and do not reflect the official policy or position of the Food and Drug Administration.
Contact: Todd Datz
JAMA and Archives Journals
View drug information on Bextra; Vioxx.
Two new review studies evaluating the safety of the pain-relieving medications selective cyclooxygenase 2 (COX-2) inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) find increased cardiovascular and kidney risks. The studies and an accompanying editorial were posted online today by JAMA because of the public health implications of the findings. The articles will appear in the October 4 print issue of JAMA.


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(What's that you say? Not as dumb as the guy who Photoshopped this in the first place? SHADDAP.)
I was woken up by the doctor's wife telling me that this lady was nearly unconscious. Halfway through rubbing my eyes, I remembered that I was a doctor and my brain started screaming the resus mnemonic at me. The air stewardess passed by, and I called her over and told her urgently "Get me a cup of water please".
"No, not water." Came the authoritative voice of Dr Baldy (not me, the other senior doctor. Imagine the rapper Pitbull except as a doctor. Wait, actually, that would make him Dr Evil. Never mind. --Editor).
I stopped. Both me and the stewardess looked at him.
"Bring her a cup of 7-Up instead. Just a small one," he said, and the stewardess nodded.
As she ran off, I asked Dr Baldy what type of doctor he was. "Oh, I'm a GP," he said. "What's with the 7-Up?" I followed. He proceeded to explain to me that in his experience as a GP, when people were feeling nauseous (like they're going to vomit), giving them plain water would often make them vomit, whereas a small quantity of a sugary carbonated drink actually helped fight the feeling and calmed them down somewhat. "7-Up seems to work the best, in my experience," he added. "I don't know why, but a lot of being a GP is working from experience".
He was right. The lady felt better and less thirsty, and she didn't throw up.
Later after the flight landed, I thanked him for the tip. "Any other last tips?" I asked him.
"Just one. Don't work in the NHS." He winked, put his arm around his wife, and headed for his connecting flight.
So kids, the next time you feel sick from catching a virus/eating bad food/reading this blog, remember - SIP SOME 7-UP, NOT WATER. See? Who said reading my blog wasn't educational?
If you liked this post, please consider liking our Facebook page. If you didn't like the post, go like my Facebook page anyway. I love you long time.

subset: commoncrawl


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jaegerm needed a new logo design and created a contest on 99designs.
A winner was selected from 47 designs submitted by 18 freelance designers.
The Council for Innovation is looking for a fresh look that represents the organization for what it is (see description below of organization). Will need to include Council for Innovation as part of the logo. I encourage you to contact me via email at firstname.lastname@example.com at anytime with questions.
Council for Innovation
Desired Color Scheme:
None specific - needs to be professional and energetic. Will need color and grayscale at end
Accepted File Formats:
Standard Web Formats (.jpg, .gif or .png); Vector Formats (.eps, .pdf or .ai); Layered Formats (.psd or .tiff)
 The Vision, Mission and Purpose of the Council for Innovation is listed below.Â
Vision (Cultivate)
The Council for Innovation (CFI) is a catalyst for the entrepreneurial spirit. CFI cultivates a culture of innovation and entrepreneurship to vault our local community's innovative companies into and across the regional, national, and global economies as high-impact businesses.
Mission (Identify, Enable, Promote)
CFI identifies, enables, and promotes high-growth, high-impact innovative and entrepreneurial companies and accelerates their success in our local community and beyond.
Purpose (Facilitate)
CFI facilitates the exchange and delivery of information, intelligence, and knowledge throughout a distributed network of innovators, entrepreneurs, investors, and the people who support them. CFI acts as a nucleus and distributor of resources and assistance to innovators and entrepreneurs and their high-impact businesses.
Find out how a design contest works or learn more about our logo design services.


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CORRECTION: I had originally thought this would air Friday, but it aired this morning on ESPN2:
Vodpod videos no longer available.
Nationals' president Stan Kasten says in the interview that the presidents race is not fixed, and that "it's inevitable" that Teddy will win. He also hints that there may be more 1-on-1 races in Teddy's future like his recent race against the Orioles Bird.
Filed under: Videos | Tagged: ESPN, nationals presidents race, Presidents Race, Stan Kasten, Teddy Roosevelt |


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With Christmas behind them, the Oregon Ducks arrived in Arizona on Wednesday afternoon to begin final preparations for the Tostitos Fiesta Bowl next week.
Oregon head coach Chip Kelly spoke with media after arriving, addressing topics such as the rumors surrounding Kelly leaving for the NFL after this season, the Stanford loss and how the team has recovered, and bowl preparation.
Opening Statement:
"Our players got an opportunity, like our coaches at times, to go home for Christmas, so we've been off since the 22nd. I actually had an opportunity to go home, so it was pretty good. We tell our players every year, our goal is to spend Thanksgiving together, Christmas with our families and New Year's together. So for the fourth year in a row they've done it. We're excited to be here. There's a familiarity for us as a group. About 50 of our players and our entire coaching staff was here two years ago (for the 2011 Tostitos BCS National Championship Game). Had a great experience. We're practicing at the same high school, we're staying at the same hotel, so I think that part of it will give us a little bit of an understanding of what's going on. We know where everything is a! nd can point the younger guys in the right direction. We're excited to get going. We'll have a brief team meeting tonight and we start back in earnest tomorrow."
Q: Has the team rebounded from the loss to Stanford?
A: "There's not much you can do about the past. If you're still thinking about what happened when we played Stanford, and we got beat by a real good team in overtime. We all know the rules of engagement when this thing started, and we've talked about it. If you lose in the regular season, there's an opportunity that you're not going to get there. We lost. We understand it. We make our own beds. We lie in them. We got ready to go. I think the way our kids responded and played the next week, in our next game, really told you what this team was all about. I think on that Monday after the Stanford game our kids understood what was at stake."
Q: On whether he is interested in an NFL job?
A: "I'm coaching the Fiesta Bowl, and that's where my sole attention is. That's all I've always had my plan to do. I'm going to coach this team, and that's it."
Q: Are the rumors (about NFL jobs) distracting?
A: "It doesn't bother me. It gives you guys stuff to write about, so I think you're entertained by it. But because I don't read it, it doesn't mean anything to me."
Q: Do you have NFL ambitions?
A: "My whole thing since I've been here is that I'm going to do the best job I can every single day. If that's good enough that other people look at you sometimes, I don't really care about that. I think too many people live in the future. We live in the moment. Our football team lives in the moment. I think how you've watch us play over the last four years, we've always lived in the moment. The only thing we can control is today. I'm always worried about today, always concerned about today. I'm going to get up tomorrow and try to replicate that again. Our whole thing about our football team is about being consistent, so if my approach was to look at what's going to happen five years down the road, ten years down the road…it's never been my philosophy, never will be my philosophy. I'm excited about a team meeting we're going to have ! here in about an hour and a half, and that's about it…My heart is to win the day, and that's it. I know everybody wants to hear a different answer, and I know at times when I don't give you guys the answer you guys want, then I'm being evasive. I'm not being evasive. My job is to coach the University of Oregon football team, and I love doing it. And that's what I'm going to do."
Q: Why arrive more than a week before the Tostitos Fiesta Bowl?
A: "Because we gave them such a break at Christmas, we felt like this was what we had to do, because we weren't going to fly everybody back to Eugene and then relocate for a day and then come back…I thought it was really important for our guys to get home for an extended period of time because we've had them since August 6. These kids haven't had a break at all. Went through Thanksgiving. So we felt it was important for them to get the break that we gave them over Christmas."
Q: Does your bowl prep stay the same every year?
A: "We're pretty consistent…Our game plan's been implemented, offense, defense, special teams, so now it's just refining it, getting back. I don't anticipate having any rust. They didn't have enough time off to get it…We've been pretty consistent with this being our fourth BCS game."
Q: Do your players take BCS games for granted?
A: "That's never been our mentality, because we're always a positive-looking operation and going forward. I don't sense that from our guys, the kids that we coach. There's still a youthful enthusiasm to this team. There's 65 freshmen and sophomores that weren't here two years ago. The one thing that I think is unique, especially in college football, is it's turned over every year. There's a bunch of guys coming in, so there'll be a bunch of new faces…It's a good mix. You never know, but I don't think in anything in life you can take for granted. That's the one thing you've got to really realize, and we try to teach as a teachable moment, is that these opportunities aren't given to anybody. You've got to earn them, and I think our players understand that. They understand the pain after ! we lost to Stanford but know that we had a great chance to go to something else if we go out and played well against Oregon State, and I was really proud of how they played that week, so I don't think they take it for granted."
Stay tuned for continued Fiesta Bowl coverage from the EDN sports crew throughout the week as the Ducks prepare to take on the Kansas State Wildcats.


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Toronto-based Red, a renewable energy projects developer, owner and operator, co-developed the Ontario projects for the past 14 months with WWPC.
Canadian power producer Capstone Infrastructure acquired Red for C$70 million ($66.6 million) in July.
Jeff Jenner, Red's president and CEO, said: "I am very pleased to complete this transaction and increase our contracted development pipeline of projects.
"With the strength of our financial partner and the proposed arrangement with Capstone Infrastructure, these development projects will be fully supported as they move into construction and operation."
It is expected Red and its financial partner, which secured loans to the Ontario projects during 2012, will each hold a 50% ownership interest in the projects once they are completed, and will equally fund the project construction costs in 2014.


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Step 1. If you are on Digicel's network, click 'Connect with your Digicel ID' to log in automatically.
Step 2. Go to Menu and Select 'Request Credit'.
Step 3. Enter Number and amount.
Step 4. Confirm that this is the number you wish to request from.
Step 5. A confirmation message will pop up and advise the request has been sent.
Please note: Screenshots are for the updated version of the app. Be sure to download the updated version for your phone today!


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Master of the View of St. Gudule
Belgian, active 15th century
The Flagellation of Christ, c. 1480
oil, tempera on panel
71.3 x 39.5 cm
Collection of the Winnipeg Art Gallery; Gift of Lord and Lady Gort
This brilliantly coloured late fifteenth-century panel painting, identified with South German and Northern Netherlandish traditions, depicts the Flagellation of Christ, also referred to as Christ at the Column. The WAG panel was part of a triptych or multi-panelled altarpiece featuring a series of scenes from the Passion of Christ. The central panel would have depicted the Crucifixion realized in a relief sculpture. Divided into distinct architectural spaces, the WAG painting allows the viewer to witness the events leading up to and following the Flagellation (visible in the left and right background) while keeping the focus on the motley group of Christ's tormentors. They appear poised to strike at their prisoner, who directs his gaze to the viewer, challenging one to ponder the grave injustice of the event. The figure of St. Augustine, a celebrated Latin theologian, is depicted in robes and mitre on the reverse side of the panel.
Gallery Hours
- Tuesday 11am-5pm
- Wednesday 11am-5pm
- Thursday 11am-5pm
- Friday 11am-9pm
- Saturday 11am-5pm
- Sunday 11am-5pm
- Closed Monday


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Öl und Gas
Der SRU zitiert hier die o. December 0 Comments. Viele Unternehmen verhängen deshalb einen Investitionsstopp.
2. Ölpreise und Ölmärkte: Vor der Krise?
Many people have lost significant amounts of weight while taking GC twice per day. There are a lot of people putting out Garcinia Cambogia reviews and most users have a great experience with the extract. There are simple directions that come with the product that you should follow to ensure maximum success. Some of these include taking the supplement in the same routine every day and eating less as your appetite becomes lessened. The specific amount of weight you will be able to shed depends on many different factors- but many people report improvements of over 9 kg in a matter of weeks.


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When Michele Foust received a diagnosis of Stage 2 breast cancer this spring, she typed out a list of questions about her treatment.
At the top of the 26-year-old's concerns was an unknown that haunts many young cancer patients: "If I survive, will I be able to have children?"
Foust's breast surgeon was unsure and told her she thought it was likely that chemotherapy would impair her chances by damaging healthy eggs as fast as it killed other rapidly dividing healthy cells such as hair follicles.
Indeed, says Neelima Denduluri, a breast medical oncologist at Virginia Hospital Center, "chemo is a real risk to fertility." Certain regimens, she says, "are more likely to cause infertility and decreasing of sperm count," with up to 80 percent of patients affected, with exact rates depending on the type of cancer treatment and age at diagnosis.
Despite this, medicine has come a long way recently toward helping cancer patients — women especially — preserve fertility prior to treatment.
The most common and successful option for a woman with cancer is freezing an egg or embryo before undergoing chemotherapy or radiation. Once the patient decides she is ready to get pregnant, she is given estrogen and progesterone to prepare the lining of the uterus. The embryo is then thawed (or the egg is inseminated) and transferred into the uterus. Success rates specifically for cancer patients have not yet been studied. But in vitro fertilization (IVF) rates are around 50 percent for women younger than 35.
(For men with cancer, freezing sperm before treatment is far less invasive and less expensive.)
There are also experimental options such as ovarian tissue freezing, in which all or part of an ovary is removed and the outer area, which contains the eggs, is frozen in strips for later use. The ovary can be reimplanted when the patient is well. The procedure typically costs around $12,000; because it is experimental, research centers often provide funding, according to Teresa Woodruff, a professor of obstetrics and gynecology at the Feinberg School of Medicine at Northwestern University. Woodruff refers to such procedures as part of oncofertility, a new discipline that bridges oncology and reproductive medicine.
"I really appreciated there were so many advances in cancer therapy, yet so many young survivors were ending up sterilized," Woodruff said. "There was a real need for a focus specifically in this field."
About 140,230 Americans younger than 45 will receive a cancer diagnosis this year, the American Cancer Society projects. The large majority of them are likely to survive for five years or more.
But only recently has fertility been factored into a patient's treatment plan, according to Mark Payson, a reproductive endocrinologist at Dominion Fertility, a practice based in Arlington. When he speaks to breast cancer support groups, patients say that "only half of their oncologists talk to them about fertility options."
Last month, a study by researchers at the University of Sheffield in England found that only 40 percent of young female cancer patients were happy with the way their doctors discussed the options they had to preserve fertility.
Most doctors are typically more concerned with saving the patient's life than with fertility options, Payson said.
When Ilana Brunner's breast cancer was discovered in 2009, she quickly embarked on fertility treatments in order to freeze some embryos before chemo began. But she was concerned others might not know to take the same steps.
"When I started chemo, they hooked me up to the machine and made me watch a video about cancer and chemo. But the video never mentioned fertility for women," though it mentioned it for men, said Brunner, a 40-year-old lawyer who lives in Silver Spring. "I actually complained. To me, it was a travesty."
Foust's fate was different. A few days after her initial conversation, she and her husband got an urgent phone call with a new plan for her treatment.
Her breast surgeon at Virginia Hospital Center had set up a conference call with Stephen Lincoln, a reproductive endrocrinologist with the Genetics & IVF Institute's fertility preservation center for cancer patients:
She would be able to try to freeze her eggs or embryos before her treatment.
Genetics & IVF, along with other well-known fertility centers including Shady Grove Fertility Center and Dominion Fertility, is part of a nationwide effort to encourage oncologists and their staffs to talk to cancer patients about their increasing fertility options.
"Everyone is recognizing now that talking about fertility is a part of dealing with cancer," Lincoln said. "People aren't just being rushed right into treatment anymore."
Denduluri concurs. "The awareness is just much higher now, whereas before many were concerned with finding the so-called cure and saving the patient's life," she said. "It's more a balancing act now, and there are more strident feelings about the importance of bringing up fertility issues at the beginning of treatment."
In late May, Foust went to the Genetics & IVF pharmacy near her home in Annandale and went home with a supply of vials of gonadotropins, hormones that stimulate the ovaries to produce eggs for retrieval.
She would have to give herself injections every day for the next two weeks. Then Lincoln and his team would extract her eggs, a procedure done with light sedation. (The process is typically the same one used for any woman who would like to have her eggs frozen to preserve her ability to have children.)
In breast cancer cases, doctors want to keep estrogen levels low because of concern that raising them might accelerate the growth of a tumor. Foust's doctors combined a low dose of gonadotropin and a medication that promotes ovarian stimulation while keeping estrogen levels low.
"It was amazing that they could actually do this, safely. At the same time, you never think as a 26-year-old that the ability to bear children — something I was looking forward to — will be taken away from you," said Foust, an emergency room nurse.
She decided to freeze eggs instead of embryos because she was concerned about having embryos she might not use. There was also a chance that she could have children naturally, depending on how much harm chemotherapy caused to her fertility.
"If I had children somewhere frozen, I would wonder what to do: Do you donate them? Do you send them to science?" she said.
Just a few years ago, Foust wouldn't have been able to consider this problem.
Back then, egg freezing had far lower success rates and was considered experimental by the American Society for Reproductive Medicine. That label was lifted in October, thanks to improved success rates with a new flash-freezing technology known as vitrification.
"It's been a massive leap forward," said Frank Chang, a reproductive endocrinologist at Shady Grove Fertility Center.
A growing number of oncologists reject the traditional view that the hormones used to stimulate eggs for retrieval — as well as pregnancy itself — might increase the risk of developing certain cancers. Today many doctors see both the freezing process and pregnancy as safe after three to five years of tamoxifen, a hormone drug used with breast cancer patients, according to Denduluri.
And although large-scale data are still being collected about recurrence rates after pregnancy, tumor histories are also looked at on a case-by-case basis to see if carrying a baby is safe, according to Denduluri.
There are also smaller studies showing that pregnancy after a breast cancer diagnosis does not carry a negative outcome as long as a patient waits two to three years after starting treatment with tamoxifen, Denduluri said.
For many patients, dealing with infertility treatments amid a cancer diagnosis is an emotional (and sometimes physical) encumbrance. It is also expensive.
Treatments are viewed as elective and are rarely covered by insurance. Fertility drugs can cost $6,000 a round or more; egg retrieval and freezing can be another $5,500. For freezing embryos, the process can run $6,500 and more.
Many fertility centers help cancer patients find help with funding their drugs. The Livestrong Foundation's Fertile Hope program has helped close to 4,000 survivors since 2004, said Ashley Koenings, senior navigator for fertility services. Each month, the program helps about 80 people.
Shady Grove works with Walgreens, which donates drugs to patients whose insurance does not cover them. Shady Grove also has financial assistance for egg retrieval, depending on a patient's income level.
But even with financial help, the emotional toll is often severe. Dealing with fertility issues is a roller coaster ride for anyone, but for cancer patients and survivors, it can feel even more burdensome.
"For once, could my body work with me instead of against me?" Brunner said of her efforts to retrieve her eggs. "During that time, a pregnant woman in a supermarket put me in tears."
Brunner froze her eggs twice — once before her double mastectomy and another time before chemotherapy. "Someone said, 'Are you sure you want to do this and start poking yourself with needles?' And I said, 'This is nothing compared to what I have to do with cancer.' "
After two unsuccessful embryo transfers, including with a gestational carrier (a woman who volunteered to carry the pregnancy for Brunner), she tried again, post chemo. She was able to get one viable egg the first round and one more the second. Both were fertilized with her husband's sperm using IVF and were implanted in a new gestational carrier. Her positive outcome in retrieving viable eggs after chemo is uncommon, doctors said. Today, she has twins who are 9 months old.
At a recent Shady Grove Fertility's Family Day, her twins wore onesies that said, "Made with love . . . and science."
"Even when they are both crying and I've had no sleep, I am so thankful," she said.
Meanwhile, Foust was able to freeze 15 eggs. When she is ready to become pregnant, the eggs can be thawed, fertilized and transferred to the uterus as embryos.
She is currently going through eight rounds of chemotherapy. Knowing that her eggs are frozen brings her comfort.
"I remember seeing a picture in my breast surgeon's office that has a list of things that cancer cannot do," she said. "And I wanted that to include that it couldn't take a pregnancy away from us. Even if we never use the eggs or get pregnant on our own, it would be a blessing. I refer to my frozen eggs as my pocketful of sunshine."


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Nothing is simple any more. Getting on (and off) an airplane, changing channels on your TV, figuring out why the "check engine" light keeps flashing on your dashboard. Oh, it's such a long list.
So, why would I think that buying some functional, basic men's rainwear would be easy?
For weeks now I've been buried under a mountain of jargon, quasi-science and hype, trying to make sense of the various high and low-tech fabrics and features. All I was looking for was something you could throw in your backpack or briefcase in case of rain.
This mission took me through the perils of zipper chafe, the nuances of taped seams and the mysteries of waterproof ratings. What I learned — and it applies to womenswear too — is that it doesn't have to be that complicated.
I've looked over dozens of hooded, zip-front jackets like the seven shown here. Then, after trying them on, fooling with all the Velcro and gizmos, reading the encyclopedia of information on the tags, I was just getting more confused.
With the help of a confessed "gear nerd" at Outside magazine — senior editor Grayson Schaffer — I've finally figured out that there are only a few things that you need to know to make a smart purchase that will fit your needs.
What a relief. Schaffer said to pay no attention to all those crazy waterproof ratings that manufacturers boast about. He said, "Those numbers are not going to lead you to the best jacket." Whew!
So, what
going to lead you to the best jacket? Pared down to the essentials, Schaffer's advice is to ask yourself what's important, what you need it for and what features you can do without.
Do you want serious protection: to stay dry in a torrential downpour?
"Go with a brand name fabric" (like Gore-Tex, HyVen t, h2no, eVent) "and a name brand jacket" (Marmot, Mountain Hardwear, The North Face, Patagonia, REI, Eastern Mountain Sports, etc.).
Need something that you grab from the back seat of the car to throw on just long enough to dash through the rain into your house?
A $30 nylon Coleman from Walmart will do (top left).
It must be really lightweight and supremely packable?
There are some jackets that weigh only 8 ounces and squeeze down to the size of your fist, like the Marmot Super Mica, for about $200. But if you can handle 6 more ounces and a little more bulk, save $50 by buying the Marmot Aegis Jacket, the bright blue one at the bottom.
Expect it to last for many years?
Look at the seams. They should be taped or welded. If the seams are merely stitched, you're going to have leaks.
Worried about getting hot or clammy?
Look for pit zips — zippers at the armpits to ventilate.
Need to carry bulky stuff?
Check for large chest pockets that will zip closed (not snap or Velcro only) around the largest thing you haul (a water bottle?).
Want to save money?
"What you can do with $50 is not much." But for $150 to $200 "you can find some nice fabric and important features." End-of-season sales help keep price down.
How about really cheap?
"If you want full waterproofness but breathability is not important, buy a plastic poncho for $1" — like they sell at sporting events and outdoor concerts. It will work for a single downpour. Ditto a big black plastic bag with holes cut for head and arms.
Still confused?
Shops specializing in outdoor gear have salespeople who know the options and can help you decide what you need. Or check gear ratings such as Outside magazine's summer 2010 Buyer's Guide in early May.
What every jacket should have
Adjustable cuffs
Draw cord at hem and hood
Ample chest pockets
Easy-to-work zipper
Collar that protects from zipper chafe


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- Meeting Program
- Meeting Summary
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- Travel / Transportation
- Conference Location
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This meeting will be conducted in English.
All programs are subject to change. Check this site for updates.
This meeting is part of the Global Health Series
Download Flyer
Twitter hashtag for this meeting: #KSnewtb


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Hi everyone, this is Gwen from This and That by Gwen sharing a fun card.
I love the colors of this card, they are so warm and inviting. This is the LeMoyne Star quilt pattern. The star was cut from the Art Philosophy cartridge and then cut apart to make the diamond shapes. Every other diamond shape is popped up.
The tag was made with the Ribbon Banners - Straight metal dies (I just cut the end off of it) and stamped with the new Fall Leaves stamp set, both from My Craft Spot.
Have a great day!


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to grips with
Man, as a tool-using animal, must have
learned in the Stone Age that tools are
not worth much unless you know how
to use them. Yet learning to use tools, as
any artisan knows, takes experience
and usually much painstaking practice.
When the tool is a new one, you have
to learn not only how to use it, but what
can be done with it. The inventors of
basic handtools are lost in the mists
of history, but the Hepplewhites and
Chippendales who used them are not
likely to be soon forgotten. A whole
generation passed between the time
when James Watt patented the steam
engine and the day when the first ship
was propelled by steam.
The H&S Auditape System has been
called an important advance in auditing
techniques for the computer age.
It is reasonable to expect that experience
will reveal vast and unexpected
opportunities to use it. But like most
new tools, Auditape may not give up its
secrets easily. We have no master
craftsmen preceding us to show us how
to use it to full capacity. Finding new
applications for Auditape will challenge
our ingenuity, because some of the
problems it can help to solve are neither
elementary nor obvious.
Ingenuity will flourish best if we
have a clear understanding of how
Auditape works and then learn to look
at problems from new angles until we
find solutions. The following case illustrates
how ingenuity and persistence
were combined to solve a client problem
in an imaginative way.
A client maintained his open accounts-
payable invoices on magnetic
tape in variable-length format. The format
is described as variable-length because
the record pertaining to each
vendor might contain a different number
of characters from every other vendor's
record. In this case, after a header
record consisting of 90 characters of
identification data, the tape contained
a variable number of invoice records of
30 characters each. Following this
there was a trailer, or summary record
for each vendor, of 40 characters containing
totals of year-to-date payments.
No. of Date of Paym't
inv. last to
paid paym't date


text:
Introduce others to the peaceful world of rebreathers. This is a fast-growing segment of diving, moving quickly into the mainstream. As unit costs decrease and the advantages of rebreather diving are readily seen, more divers are becoming interested in the benefits of this technology. Take advantage of this increasing demand as a Rebreather Instructor.
Please, contact a Blue Horizons Training Consultant for details. Call to schedule your class today, or click the e-mail button, below.
Scuba Tune-Up classes are conducted every first Saturday of each month. Call to schedule your class, today or send us an e-mail.
Are you a certified diver who hasn't been able to get in the water enough —too much work, not enough play?
Join us on the first Saturday of each month (excludes December) for $10 Bubbles and a Beer. For $10, any certified diver can join us in the pool. Tank is included. Don't have your own gear yet? For another $10 you will get an entire scuba kit to use.
Cylinder and weights are included with first $10.
Right after the event, we will head to one of the local watering holes/restaurants to grab a beer, some food & hang out. The restaurant will be a family-friendly establishment, welcoming those who can drink beer, as well as those who can only drink root beer. For those who want to drink beer, proper ID and legal age are required.
Come as often as you like; we would love to see you. Blowing bubbles is always a great time, even if it's just in the pool. Please call to sign up so we know how many are coming.
Event costs include scuba-related activities, only.
Private dates are available for all courses — by appointment.
Now enrolling.
Please, contact our Blue Horizons Course Director's Office for details, or click the e-mail button, below.


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NAIA Wrestler of the Week ? No. 3
KANSAS CITY, Mo. – Ryak Finch of Grand View (Iowa) has been named the NAIA National Wrestler of the Week, the national office announced Wednesday. Finch was selected based on his performances from Jan. 20 – 26 and was chosen out of a pool of nominees from the four Qualifying Groups.
Finch, a junior from Reading, Ariz., compiled a 5-0 record during the week, including three victories against NCAA Division I opponents. In the Vikings Jan. 23 dual against NCAA Division II No. 19 Maryville (Mo.), Finch tallied four of Grand View's 33 points with a major decision (14-4) victory against Brandon Oshiro. The 125-pounder continued his stellar week on Jan. 25 at the Grand View Open, with a pair of technical falls against Drake Swarm of NCAA Division I Iowa State and Phil Lauk of NCAA Division I Iowa, and a pin of Dakota Leach of NCAA Division I Southern Illinois Edwardsville. He also was credited with a win by forfeit at the event.
On the season, Finch, who is the top-ranked 125-pound wrestler in the NAIA, owns a 20-0 record.
The next Wrestler of the Week announcement will be on Feb. 5. For the complete Player of the Week calendar, click here.
Nominees: Eric Lopez, Menlo (Calif.); Carlos Toledano, Doane (Neb.); Austin Fehlhafer, Concordia (Neb.); Eric Gruis, Dakota Wesleyan (S.D.); Nico Martinez, Missouri Valley; Bryce Shoemaker , Baker (Kan.); Dirk Ponchak, West Virginia Tech; Sam Johnson, Cumberlands (Ky.); Scott Stewart, Cumberland (Tenn.).
2013-14 NAIA Wrestlers of the Week
Week 1 (Jan. 15): Joe Cozart, Lindsey Wilson (Ky.)
Week 2 (Jan. 22): Javier Carbajal, Cumberlands (Ky.)
Week 3 (Jan. 29): Ryak Finch, Grand View (Iowa)


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Seattle SU Cornhole Boards, Custom All Weather Cornhole Bags & Carrying Case Package
Product Features
- Officially Licensed Collegiate Product
- ACA Regulation Size 24" x 48"
- Tournament Grade Construction
- Includes Bag Set & Folding Legs
- Fully Assembled & Made in the USA
With this set you get two high quality cornhole boards with folding legs, a complete bag set (8 bags CUSTOM LOGO ALL WEATHER), CUSTOM LOGO CARRYING CASE, and a FREE string pack to carry the bags (A $10 value!). This set comes ready to play right out of the box as shown here! All boards are 24"x48" regulation size. Our custom sets take a few days to complete plus 1 to 5 days for delivery. Allow 10 business days for production and shipping. If you need something faster please contact us.
Our boards are quality constructed using 1/2" cabinet grade plywood. Not the cheap stuff many other dealers use. 24"x 48" (2 feet by 4 feet) with the 6" hole centered 9" from the top and 12" from each side. The play surface is framed with sturdy 2x4 boards and folding legs for portability. The back measures 12" off the ground and the front measures 4" off the ground.
Our all weather bags are made of quality Duck Cloth canvas material measuring 6"x 6" and will last for years to come.
Show off your team spirit with our officially licensed cornhole carrying case! Store and carry your full sized 24x48 cornhole set in our heavy duty, high quality cornhole carrying case which also doubles as a storage bag. Made of high quality, durable PVC-backed weather resistant canvas materials, strong triple stitched 60 inch nylon carrying straps, and quality zippers, you can finally store and protect your cornhole set with ease. We use the same material many luggage manufacturers use. This case is large enough to store two full size 24x48 cornhole boards that use 2x4 (or smaller) frames with folding legs and your accessories. Another unique feature of our exclusive case is that it is easy to load. Even one person can do it! Just set your boards on their end and pull the case over one end and pull down. Set them down, zip up the end, and your done! This is an officially licensed product.
- Standard Features
- Quality 1/2" Plywood Tops - Smooth finish, excellent playability.
- This is not like the plywood you buy at the local hardware store!
- Standard plywood tends to warp, may have voids, knots, etc.
- Top Choice Finish Grade 2x4s - Superior to the basic framing boards others use.
- Finished with clear gloss sealant for protection.
- Strong pocket hole joint construction.
- Perfect 6" holes. No jigsaws here!
- No visible screw holes or spackle on any surface.
- Strong, foldable 2x4 leg construction with carriage bolts and wing nuts.
- Our legs won't snap in half when your friend or kids accidentally stand on our boards!
- No tripping over our legs! Our legs do not fold back behind the board.
- We touch up the joints, bleed, etc. to give our boards a quality finished look.
If you are interested in buying any of the items separate please contact us and we will get back with you ASAP.


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With three main airports serving the five boroughs of New York City, all managed by the Port Authority of New York & New Jersey, you're truly spoiled for choice when you're seeking cheap flights to New York City. Where you land will likely be determined by where you take off from, since each airport best serves different parts of the country and the world.
LaGuardia Airport is the closest to Manhattan and typically handles most domestic flights. Located in Queens, the airport has been operating as LaGuardia since 1947, but the land has been used as an airfield from as far back as 1929. Flights to LaGuardia operate from four terminals.
Terminal A is the original airport building, and Delta operates a number of daily shuttle flights to New York City from Boston, Washington, D.C., and Chicago. Terminal B is the largest terminal -- usually referred to as the Central Terminal Building. It handles most of the domestic airlines' scheduled flights. Terminal C was built in 1992, and is also a hub for Delta fights, as well as US Airways and the Canadian carrier WestJet. Terminal D is connected to Terminal C by a walkway; it services Delta Airlines flights from its 10 gates.
There is no border control at LaGuardia, so the flights arriving from Canadian airlines are pre-cleared by customs before leaving Canada.
John F. Kennedy International Airport -- better known as just JFK -- is a little farther south, but also in Queens. Originally called New York International Airport, JFK saw its billionth traveler walk through its gates in 2000, and in 2013 it welcomed a record 50 million passengers. JFK is where The Beatles famously disembarked for their first US tour, and countless heads of state and international dignitaries arrive at JFK every year.
Currently there are six operating terminals at JFK. There are 11 gates at Terminal 1 that service four airlines: Air France, Japan Airlines, Korean Air, and Lufthansa. Delta Airlines operates out of Terminal 2, and Terminal 4 serves as its major international hub. Flights operated by Swiss International Air Lines, Asiana Airlines, Singapore Airlines, EgyptAir, Emirates, Pakistan International Airlines, Kuwait Airways, Etihad Airways, KLM, and Avianca also fly out of Terminal 4.
Low-cost carrier JetBlue is the main resident of JFK's Terminal 5, but now Hawaiian Airlines and Ireland's Aer Lingus operate flights to New York City here as well. Terminal 7 is home to British Airways, but Cathay Pacific, Iberia, Qantas, United Airlines, and ANA also use Terminal 7's 12 gates. Terminal 8 is home to the OneWorld alliance -- American Airlines operates the most flights from here, but Finnair, Royal Jordanian Airlines, Air Berlin, Qatar Airways, LAN Airlines, TAM Airlines, and US Airways also operate flights out of Terminal 8's 29 gates.
Newark Liberty International Airport is in New Jersey, and since it's a bit farther afield than LaGuardia or JFK, you can often find great deals for flights to New York City. More than 150 non-stop destinations are served by the 25 airlines that operate out of Newark's three terminals. Terminal A has no immigration facilities, so it mostly houses domestic scheduled flights. Terminal B is mainly international airlines and flights, and Terminal C is a main hub for United Airlines, with domestic and international flights to New York City operating from its 59 gates.
The Port Authority of New York & New Jersey also manages three other airports in the region: Stewart International Airport, which is 60 miles north of NYC in the Hudson Valley, Atlantic City International Airport, which is roughly 125 miles southwest of Manhattan in South Jersey, and Teterboro -- a relief airport just 12 miles from NYC that mainly handles smaller aircraft and domestic charter airlines.
Finding cheap flights to New York City will probably be the easiest part of planning a trip on a budget. In fact, the challenge may lie in narrowing down your affordable airfare options. The three main airports manage over 4,000 flights daily, providing many opportunities to get a great flight at a great price. Since all major airlines fly into all or most of the area's major airports, you can focus on the low-cost carriers for the best deals. But don't rule out the major airlines either! They often have flights into New York every hour, and frequently offer deep discounts to fill empty seats.
Delta has a domestic hub in LaGuardia, and their international hub is at John F. Kennedy. JFK also serves as the international hub for American Airlines and is the operating base for JetBlue; it also serves as a secondary hub for both Alaska Airlines and America West. United Airlines' area hub is at Newark. Using a flight search aggregator like Hipmunk is your best bet for narrowing down your many options to the best combination of price and flight time.
New York City is one of those special destinations where high season happens year-round. It's most hopping between March and December, although the slightly quieter months of January and February are interrupted with romance seekers around Valentine's Day. But much of the beauty and excitement of New York is due to the hustle and bustle, so there is really no point in trying to avoid the crowds. If you visit during July and August, you may find the streets a tad quieter, but that's likely because many local New Yorkers have fled for nearby beaches in Long Island and New Jersey.
The weeks just before Thanksgiving in November through to January are the busiest and it's the most expensive time to visit New York. International visitors and tri-state area residents alike flock to Manhattan to experience the holiday decorations, activities, and shows that celebrate the festive season.
Transportation is another of the more affordable things to include in your getaway budget. In addition to the abundance of cheap flights to New York, getting around Manhattan and the five boroughs is also remarkably affordable. While taxis from the airport can seem pretty steep, especially from JFK and Newark, once you're in town the fares seem much more reasonable, even if you're going more than a few blocks.
Although there is an abundance of private shuttle companies that are convenient and quite affordable, using public transit and train service is definitely the easiest and cheapest way to get to and from the area airports and around town.
It takes roughly 30 minutes on the train from Newark to Manhattan's Penn Station, and costs $12.50. There are two AirTrain routes available to Manhattan from JFK -- they range between 30 and 50 minutes and involve transferring to Manhattan Transit Authority (MTA) subways. The fares range from $7.50 to $15.50 for those routes, and you can purchase a pre-paid MTA Metrocard at JFK that can be used on all MTA vehicles. LaGuardia has an MTA express bus service that connects to the city for a fare of only $2.50, and prepaid fare cards can also be purchased at LaGuardia.
The New York City subway system may seem intimidating, but it truly is an easy and affordable way to get around the city. The free Citymapper app can assist with real-time routes, maps, and directions to help you find your way.
Many of the best New York City attractions are low-cost or no cost. Times Square, the New York Public Library, Central Park, Rockefeller Center, and the Staten Island ferry are all free. Many of the museums are free for young children, and most of the area's smaller museums and galleries encourage a suggested contribution instead of an entry fee. If shows and attractions are musts for your trip, the NYC CityPASS will save you 40% on admission to six top attractions -- including the Empire State Building, the American Museum of Natural History, the Metropolitan Museum of Art, and the Statue of Liberty & Ellis Island. Buy Broadway show tickets at the Times Square TKTS booth on the morning of the show for big savings.
With a bit of planning you can truly experience all the city has to offer. Unless you plan on shopping until you drop the whole time, a trip to New York City on a budget is totally within reach.
© 2019 Hipmunk® and Concur® Hipmunk® are trademarks of Hipmunk, Inc. and Concur Technologies, Inc.
© 2019 Hipmunk® and Concur® Hipmunk® are trademarks of Hipmunk, Inc. and Concur Technologies, Inc.


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Are you looking for some insurance company that can provide you insurances in Los Angeles, look no more. Los Angeles Car Insurance is here to save you.
Are you looking to purchase Health, Auto, Life and/or Home Insurance? You have come to the right place. Our website, InsuranceLosAngeles.us is unique in that we don't simply stick to one kind of insurance carrier, but we bring you the best deals from many online insurance carriers. This way, you have offers from multiple carriers all in one place – our website!
If you call Statefarm or another insurance company, they will attempt to sell you just the insurances they offer. And while Statefarm may offer cheaper home insurance quotes, their car insurance may cost more than Mercury. Therefore, you should never stick to one company when purchasing insurance.
On our site, you will be to access quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. All you have to do is pick the plan that works for you!
Our customer service agents are standing by to help you purchase Life Insurance, Car Insurance Los Angeles, Health Insurance, and/ or Home Insurance in Los Angeles. Our website will guide you to many compatible insurance offers.
SERVICES InsuranceLosAngeles.us Offers:
Health Insurance – Check out different medical plans for your family, your employees, or yourself, from HMO to PPO, we offer cheap rates for all types of health insurances.
Los Angeles Auto Insurance – You are already aware that you must purchase car insurance if you drive a car or truck by California law. So, help yourself out by finding the most comprehensive and cheapest rate available.
Life Insurance – There are many life insurance policies out there, such as term and universal life insurance. They all offer various things, from different monthly payments, to different payout structures throughout your lifetime, or if you happen to pass away. Check out different options on our website.
Home Insurance – Protecting your property is just smart. You definitely want to make sure that you are protected in case any kind of damage to your property occurs. You'll want to pick the best policy that will protect your investment and your belongings without breaking the bank.
We are here to help you find the most affordable, compatible and comprehensive insurance coverage offered anywhere!


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SMART-1 detects calcium on the Moon
Thanks to measurements by the D-CIXS X-ray spectrometer, ESA's SMART-1 spacecraft has made the first ever unambiguous remote-sensing detection of calcium on the Moon.
SMART-1 is currently performing the verification and calibration of its instruments, while flying in its science orbit, reaching 450 kilometres from the Moon at its closest distance.
During this calibration phase, which precedes the actual science observations phase, the SMART-1 scientists are getting acquainted with the delicate operations and the performance of their instruments in the warm environment of the lunar orbit.
Although it is still preparing for full lunar operations, D-CIXS has started already sending back high-quality data. D-CIXS is designed to measure the global composition of the Moon by observing how it glows in X-rays when the Sun shines on it. In fact, different chemical elements provide their 'fingerprinting', each glowing in a unique way.
On 15 January 2005, between 07:00 and about 09:00 Central European Time, a solar flare occurred, blasting a quantity of radiation that flooded the Solar System and the Moon.
"The Sun was kind to us," said Prof. Manuel Grande of the Rutherford Appleton Laboratory, UK, leader of the D-CIXS instrument team. "It set off a large X-ray flare just as we took our first look downwards at the lunar surface."
The lunar surface reacts to the incoming solar radiation by glowing in different X-ray wavelengths. This enabled D-CIXS to distinguish the presence of chemical elements - including calcium, aluminium, silicon and iron - in Mare Crisium, the area of the lunar surface being observed at that moment.
"It is the first time ever that calcium has been unambiguously detected on the Moon by remote-sensing instrumentation," added Prof. Grande. Calcium is an important rock-forming element on the Moon.
"Even before our scientists have finished setting up the instruments, SMART-1 is already producing brand new lunar science," said Bernard Foing, SMART-1 Project Scientist. "When we get D-CIXS and the other instruments fully tuned, with scientific data rolling in routinely, we should have a truly ground-breaking mission."
D-CIXS is an ultra-compact X-ray camera and forms one of the most innovative elements of the SMART-1 scientific instrumentation. It is a cube just 15-centimetres wide, weighing less than five kilograms. D-CIXS is the first instrument of its kind to be tested in space. It is also the first X-ray spectrometer ever flown around the moon with sufficient spectral resolution to separate signals coming from different chemical elements.
For more information
Prof. Manuel Grande
SMART-1 D-CIXS Principal Investigator
CCLRC, Rutherford Appleton Laboratory
Tel: +44 1235 446501
E-mail: M.Grande @ rl.ac.uk
Bernard H. Foing
ESA SMART-1 Project scientist
Tel: +31 71 565 5647
E-mail: bernard.foing @ esa.int


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Thach Weave
The Life of Jimmie Thach
- Format:
- Pages: pages
- Published:
July 15, 2004
- Product Dimensions:
9.5 × 6.5 × 1 in
- Product Weight:
21 oz
This biography completes a trilogy on the three Navy fighter pilots--Jimmie Thach, Butch O'Hare, and Jimmy Flatley--who developed sweeping changes in aerial combat tactics during World War II. While O'Hare and Flatley were instrumental in making the "weave" a success, Thach was its theoretical innovator, and his use of the tactic in combat at Midway documented its practical application. This portrait of the famous pilot provides a memorable account of how Thach, convinced that his Wildcat was no match for Japan's formidable Zero, found a way to give his squadron a fighting chance. Using matchsticks on his kitchen table, he devised a solution that came to be called the Thach Weave. But as Steve Ewing is quick to point out, this was not Thach's sole contribution to the Navy. Throughout his forty-year career, Thach provided answers to multiple challenges facing the Navy, and his ideas were implemented service wide.
A highly decorated ace, Thach was an early test pilot, a creative task force operations officer in the last year of World War II, and an outstanding carrier commander in the Korean War. During the Cold War, he contributed to advances in antisubmarine warfare. This biography shows him to be a charismatic leader interested in everyone around him, regardless of rank or status. His dry sense of humor and constant smile attracted people from all walks of life, and he was a popular figure in Hollywood. Thach remains a hero among naval aviators, his most famous combat tactic still used by today's pilots.


text:
Skip to main content
, trading name of
Never miss a trend with Next Inspire, which showcases the latest looks in fashion and home.Explore what's new at Next with inspirational catwalk video, style picks and as seen in magazine edits. From the latest women's jeans to men's coats, maxi dresses to trouser suits and quilted jackets to occasionwear, get stylish day to night looks for the season. What's more, style guides for anything from lingerie to denim ensure you find the best fit, style and colour for you. Love what you see? Be the first to know about Next's fashion collections by joining the conversation on Twitter @nextofficial, liking Next on Facebook, following Next on Pinterest or looking at the latest snaps on Next's Instagram.


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McKENZIE WESTMORE TO HOST THE NEW REALITY-COMPETITION SERIES COMING TO SYFY
Production Underway in Los Angeles in the Search for the Next Great Special Effects Make-Up Artist
NEW YORK - November 10, 2010 - Syfy has signed Ve Neill, Glenn Hetrick and Patrick Tatopoulos as judges and McKenzie Westmore as host on Face Off, a new reality-competition series set in the magical world of world-class special effects and make-up artistry. The series will feature twelve aspiring special effects make-up artists competing for their shot at make-up-effects stardom and the chance to breakout in the competitive field. Scheduled to premiere in January 2011 on Syfy, principal photography for the eight-episode, one-hour series commenced October 20 in Los Angeles. The announcement was made today by Mark Stern, Executive Vice President of Original Programming, Syfy and Co-Head of Content for Universal Cable Productions.
"Syfy provides a definitive forum to showcase the imagination and artistry of this incredible field," said Stern. "The series will introduce twelve dynamic personalities who will display their creativity and talent through a series of weekly challenges. Given her auspicious background, McKenzie Westmore is the perfect host, and we're honored to have such renowned figures as Glenn Hetrick, Ve Neill and Patrick Tatopoulos as our judges. Their high-standards for special effects artistry will push our contestants to the top of their game."
Multiple Academy-award winner Ve Neill serves as a judge to the competing artists. One of the most renowned make-up artists in the motion picture business today, Neill has set many standards of excellence in the make-up field, earning three Academy Awards, two Emmy Awards and four Saturn Awards, among other accolades. Neill recently added Pirates of the Caribbean to her list of creations for which she was awarded the BAFTA (British Academy Award) and another Oscar nomination. Neill is also noted for transforming Johnny Depp into a scissors wielding anti-hero for Edward Scissorhands, Robin Williams into a Scottish nanny for Mrs. Doubtfire, Martin Landau into horror legend Bela Lugosi for Ed Wood and for bringing to life an onslaught of villains, beauties and superheroes in the Batman film series.
Famed special make-up effects artist Glenn Hetrick also serves as judge on the series. Hetrick is the owner of Optic Nerve Studios, Inc., where he has worked as a designer, fabricator, sculptor and painter on numerous film and television projects including Heroes, CSI: NY, Buffy the Vampire Slayer, Angel, X-Files, Babylon 5, Roswell, Pitch Black and Chronicles of Riddick, among others.
Director and creature designer Patrick Tatopoulos joins the series as a judge, bringing his distinguished and signature style to the competition. Tatopoulos has served as a production designer and creator of creature effects on such films as I Am Legend, Live Free or Die Hard, Underworld, Resident Evil: Extinction, Independence Day, Dark City, Stargate and Godzilla, for which he won a Saturn award for Best Special Effects. Tatopoulos also designed the werewolves for director Michael Doughterty's Trick R Treat and special make-up effects for Joel Schumacher's upcoming horror film, Creek. Tatopoulos also directed Underworld: Rise of the Lycans.
Host McKenzie Westmore brings a rich history and passion for the art of special effects make-up to her role. Beginning with her great-grandfather George, the Westmore family set the bar for film and television make-up; essentially pioneering the field. Her father, Michael Westmore, is the legendary make-up artist behind the TV series Star Trek. Ms. Westmore started acting at the age of three when she was cast in Raging Bull as Robert De Niro's daughter. She later went on to guest star in Weird Science, Star Trek Voyager as well as the feature film Star Trek: Insurrection. Ms. Westmore also starred on the NBC soap opera Passions.
Face Off is a competition/elimination series exploring the world of special-effects make-up artists and the unlimited imagination that allows them to create amazing works of living art. The contestants are tasked with elaborate feature challenges including executing full body paint make up on models and creating their own horror villain. Not only will the show incorporate effects make-up, it will include a wide range of skill sets including prosthetics, 3-D design, sculpting, eye enhancers, casting and molding. Each episode involves incredible reveals of the competitors' finished work, and the drama of one contestant being sent home by the panel of expert and celebrity judges. It all culminates in one winner and one grand prize that will launch a career.
Face Off is a production of Mission Control Media with Michael Agbabian and Dwight Smith serving as executive producers. Face Off is set to debut in first quarter 2011 on Syfy.
Syfy is a media destination for imagination-based entertainment. With year round acclaimed original series, events, blockbuster movies, classic science fiction and fantasy programming, a dynamic Web site (www.Syfy.com), and a portfolio of adjacent business (Syfy Ventures), Syfy is a passport to limitless possibilities. Originally launched in 1992 as SCI FI Channel, and currently in more than 98 million homes, Syfy is a network of NBC Universal, one of the world's leading media and entertainment companies. (Syfy. Imagine greater.)


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This book presents 49 space-related math problems published weekly on the SpaceMath@NASA site during the 2011-2012 academic year.
This model demonstrates convection currents and uses water, food coloring, a cup of very hot water and a votive candle as heat sources. Movie clips of demonstration setup and convection in action are provided.
In this activity students are challenged to create a model of the universe in a single class period. This activity is designed to elicit student ideas and preconceptions about the contents and organization of the cosmos.
This is a reading strategy guide in a series of guides that utilizes articles from the Great Explorations in Math and Science (GEMS) program.
This is an activity about magnetic fields. Learners will use various magnets, magnetic film, and a compass to see and illustrate what magnetic fields look like. This is the fourth activity as part of the iMAGiNETICspace: Where Imagination, Magnetism, and Space Collide educator's guide.
This game is played on an online map of a fictitious city. Players are challenged to complete an assigned trip in the most environmentally friendly way possible while staying within time constraints.
This activity is a short engineering design challenge to be completed by individual students or small teams. A real-world problem is presented, designing buildings for hurricane-prone areas, but in a simulated way that works in a classroom, after school club, or informal education setting.
In these math problems, students will examine the characteristics of water droplets in clouds.
In this interactive, online activity, students estimate the distances of objects in the Hubble Deep Field from Earth using the relationship between size, brightness, and distance. Students can complete this activity independently or in small groups.
Two comic characters, Camilla Corona, a rubber chicken, and Colours O'IRIS, a peacock, explore spectrographs. This comic is part of the series Tales from Stanford Solar.


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Pro Series Folding Plant Supports
Short Description
Unique folding and stacking plant supports.
Full Description
These sturdy, stackable supports allow you to custom-fit them to your plants. The patent-pending Burpee design is now offered in three distinct sizes, the better to support all your tomato and pepper plants. And they fold flat for easy storage.
Buy this product
Item # Product
Order: 33" Ladders (3 pack)
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Order: 45" Ladders (3 pack)
- +
Order: 57" Ladders (3 pack)
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Product properties
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the burpee
since 1876
Cucumber & Squash A-Frame Supports
Grow your best vining vegetables ever with this quick and easy support.Watch video
Pro Series Folding Plant Supports is rated out of 5 by 4.
Rated 5 out of 5 by Flyfisher from Gardening Made Easy After years of struggling with tomato poles, stakes, bamboo, and metal sticks, I bought a set of these side-folding plant supports. So easy to put in the ground and easy to tie off the plants as they grow. PROBLEMS SOLVED !!
Date published: 2017-10-13
Rated 5 out of 5 by fishbaran from As Advertised I put up the plant supports and within 48 hours my cucumber plants were attaching to them.
Date published: 2017-07-16
Rated 5 out of 5 by Maga from Very Sturdy - Multi Purpose This frame is incredibly sturdy, and I initially bought them to use for tomato plants, but my peas were in desperate need of some support. I am using Farm Daddy growing boxes, and I just opened the three of them flat and made a trellis! These supports are so well made; I can see using them for many years to come.
Date published: 2014-05-02
Rated 5 out of 5 by NYBurpeeFan from Fantastic Plant Supports! These plant supports are fantastic. Here's a great way to use them -- I fold 2 of them together to create a tomato ladder that gives me more width for the tomato to grow, and it gives more support for the tomato. There's enough of an opening for me to reach in and maneuver the plant. Once they are folded around the plant, I tie the 2 two supports together, although that's probably not even necessary once you push them into the ground. This makes it a little pricey because they come in sets of 3, but it is well worth it because two used together are quite sturdy and yet allow more room for the tomato to grow in between, yet you still have ample room to access the vines. In fact, it becomes so easy to wind the tomato vines around the supports, that I have had much less tying to do. If you found the tomato cages to be hard to manage/get into, or if you found the tomato ladders to be not wide enough, try ordering these supports, and put 2 of them together -- your problems will be solved. These are just great! Although they are fairly sturdy if 2 are used togther, the only thing I would suggest to Burpee --- PLEASE make these supports a little thicker & stronger, and about 10 inches higher....then they would be absolutely perfect and I would buy many more!
Date published: 2012-06-06


text:
When using Zend Framework's MVC layer, chances are you will be using
Zend_View is performs well
compared to other view or templating engines; since view scripts
are written in PHP, you do not incur the overhead of compiling custom
markup to PHP, nor do you need to worry that the compiled PHP is
not optimized. However,
Zend_View presents its own issues:
extension is done via overloading (view helpers), and a number of view
helpers, while carrying out key functionality do so with a performance
Zend_View "methods" are actually provided via
overloading to the helper system. This provides important
flexibility to Zend_View; instead of needing to extend Zend_View and
provide all the helper methods you may utilize in your application,
you can define your helper methods in separate classes and consume
them at will as if they were direct methods of Zend_View. This keeps
the view object itself relatively thin, and ensures that objects are
created only when needed.
Zend_View uses the PluginLoader to look
up helper classes. This means that for each helper you call,
Zend_View needs to pass the helper name to the
PluginLoader, which then needs to determine the class name, load the
class file if necessary, and then return the class name so it may be
instantiated. Subsequent uses of the helper are much faster, as
Zend_View keeps an internal registry of loaded helpers,
but if you use many helpers, the calls add up.
The question, then, is: how can you speed up helper resolution?
The simplest, cheapest solution is the same as for general PluginLoader performance: use the PluginLoader include file cache. Anecdotal evidence has shown this technique to provide a 25-30% performance gain on systems without an opcode cache, and a 40-65% gain on systems with an opcode cache.
Another solution for those seeking to tune performance even
further is to extend
Zend_View to manually add the
helper methods they most use in their application. Such helper
methods may simply manually instantiate the appropriate helper
class and proxy to it, or stuff the full helper implementation
into the method.
class My_View extends Zend_View { /** * @var array Registry of helper classes used */ protected $_localHelperObjects = array(); /** * Proxy to url view helper * * @param array $urlOptions Options passed to the assemble method of the Route object. * @param mixed $name The name of a Route to use. If null it will use the current Route * @param bool $reset Whether or not to reset the route defaults with those provided * @return string Url for the link href attribute. */ public function url(array $urlOptions = array(), $name = null, $reset = false, $encode = true ) { if (!array_key_exists('url', $this->_localHelperObjects)) { $this->_localHelperObjects['url'] = new Zend_View_Helper_Url(); $this->_localHelperObjects['url']->setView($view); } $helper = $this->_localHelperObjects['url']; return $helper->url($urlOptions, $name, $reset, $encode); } /** * Echo a message * * Direct implementation. * * @param string $string * @return string */ public function message($string) { return "
" . $this->escape($message) . "
\n"; } }
Either way, this technique will substantially reduce the overhead of the helper system by avoiding calls to the PluginLoader entirely, and either benefiting from autoloading or bypassing it altogether.
Those who use partials heavily and who profile their applications
will often immediately notice that the
partial() view
helper incurs a lot of overhead, due to the need to clone the view
object. Is it possible to speed this up?
partial() view helper accepts three arguments:
$name: the name of the view script to render
$module: the name of the module in which the
view script resides; or, if no third argument is provided
and this is an array or object, it will be the
$model argument.
$model: an array or object to pass to the
partial representing the clean data to assign to the view.
The power and use of
partial() come from the second
and third arguments. The
$module argument allows
partial() to temporarily add a script path for the
given module so that the partial view script will resolve to
that module; the
$model argument allows you to
explicitly pass variables for use with the partial view.
If you're not passing either argument, use
render() instead!
Basically, unless you are actually passing variables to the
partial and need the clean variable scope, or rendering a view
script from another MVC module, there is no reason to incur the
overhead of
partial(); instead, use
Zend_View's built-in
render() method
to render the view script.
Version 1.5.0 introduced the
action() view helper,
which allows you to dispatch an MVC action and capture its rendered
content. This provides an important step towards the DRY principle,
and promotes code reuse. However, as those who profile their
applications will quickly realize, it, too, is an expensive
operation. Internally, the
action() view helper needs
to clone new request and response objects, invoke the dispatcher,
invoke the requested controller and action, etc.
How can you speed it up?
Introduced at the same time as the
action() view
helper, the ActionStack
consists of an action helper and a front controller plugin.
Together, they allow you to push additional actions to invoke
during the dispatch cycle onto a stack. If you are calling
action() from your layout view scripts, you may
want to instead use the ActionStack, and render your views to
discrete response segments. As an example, you could write a
dispatchLoopStartup() plugin like the following to
add a login form box to each page:
class LoginPlugin extends Zend_Controller_Plugin_Abstract { protected $_stack; public function dispatchLoopStartup( Zend_Controller_Request_Abstract $request ) { $stack = $this->getStack(); $loginRequest = new Zend_Controller_Request_Simple(); $loginRequest->setControllerName('user') ->setActionName('index') ->setParam('responseSegment', 'login'); $stack->pushStack($loginRequest); } public function getStack() { if (null === $this->_stack) { $front = Zend_Controller_Front::getInstance(); if (!$front->hasPlugin('Zend_Controller_Plugin_ActionStack')) { $stack = new Zend_Controller_Plugin_ActionStack(); $front->registerPlugin($stack); } else { $stack = $front->getPlugin('ActionStack') } $this->_stack = $stack; } return $this->_stack; } }
UserController::indexAction() method might then
use the
responseSegment parameter to indicate which
response segment to render to. In the layout script, you would
then simply render that response segment:
<?= $this->layout()->login ?>
While the ActionStack still requires a dispatch cycle, this is
still cheaper than the
action() view helper as it
does not need to clone objects and reset internal state.
Additionally, it ensures that all pre/post dispatch plugins are
invoked, which may be of particular concern if you are using
front controller plugins for handling ACLs to particular
In most cases, using
action() is simply overkill.
If you have most business logic nested in your models and are
simply querying the model and passing the results to a view
script, it will typically be faster and cleaner to simply write
a view helper that pulls the model, queries it, and does
something with that information.
As an example, consider the following controller action and view script:
class BugController extends Zend_Controller_Action { public function listAction() { $model = new Bug(); $this->view->bugs = $model->fetchActive(); } } // bug/list.phtml: echo "
\n"; foreach ($this->bugs as $bug) { printf("
%s: %s
\n", $this->escape($bug->id), $this->escape($bug->summary)); } echo "
\n";
action(), you would then invoke it with the
<?= $this->action('list', 'bug') ?>
This could be refactored to a view helper that looks like the following:
class My_View_Helper_BugList extends Zend_View_Helper_Abstract { public function direct() { $model = new Bug(); $html = "
\n"; foreach ($model->fetchActive() as $bug) { $html .= sprintf( "
%s: %s
\n", $this->view->escape($bug->id), $this->view->escape($bug->summary) ); } $html .= "
\n"; return $html; } }
You would then invoke the helper as follows:
<?= $this->bugList() ?>
This has two benefits: it no longer incurs the overhead of the
action() view helper, and also presents a more
semantically understandable API.


text:
|Aliante Casino + Hotel
|North Las Vegas
Aliante Casino + Hotel, 7300 Aliante Parkway, is a Four Diamond AAA-rated resort at Aliante Parkway and Interstate 215, bringing dining, gaming and entertainment to North Las Vegas. Located across from the Aliante Golf Course, the $675 million dollar resort features more than 200 rooms and suites. It opened in 2008 as part of the Station Casino family and began ......more.
|ARIA Resort & Casino at CityCenter
|The Strip and Nearby
|The centerpiece of CityCenter Las Vegas is Aria Resort & Casino, a stunning AAA Five Diamond resort on The Strip featuring an unprecedented combination of striking architecture, sustainable design, spectacular amenities, high-end service and premium meeting and convention space. From unique culinary offerings created by the world's most talented chefs, to innovative nightlife, indulgent spa treatments and Zarkana by Cirque ......more.
|Arizona Charlie's Boulder Hotel and Casino
Just 10 minutes from downtown Las Vegas, Arizona Charlie's Boulder Casino, Hotel & RV Park offers reasonably priced rooms and dining options for locals and tourists alike.
Southwestern architecture greets guests as they enter the hotel-casino's property. The hotel features 300 affordable rooms and outside, a landscaped, 200-space RV park offers several amenities including a private clubhouse and a ......more.
|Arizona Charlie's Decatur
|Central Las Vegas
|A laid-back attitude and Wild West charm makes Arizona Charlie's Decatur a popular destination for both tourists and locals. The neighborhood casino has close to 60,000 square feet of gaming space with more than 1,200 slots; popular casino games like blackjack, craps, roulette and keno; a race and sportsbook; and bingo parlor. Dining options include comfort food favorites at the ......more.
|Aston Montelago Village Resort
|Aston Montelago Village Resort at Lake Las Vegas is a Mediterranean-styled resort that is ideal for family getaways, weddings, business conferences and more. Its old-world charm and elegance is just 20 miles from the Las Vegas Strip. The Aston Montelago Village Resort will be closing on August 31, 2016....more.
|Bally's Las Vegas
|The Strip and Nearby
|Step into the light at Bally's Las Vegas. The neon-lit entryway stands out as a symbol of Las Vegas surrounded by a series of neon columns. Bally's opened in 1973 as the original MGM Grand Hotel and Casino, and has since become a mix of old and new Vegas. The 139,251-square foot property includes 1,050 slot machines, 58 gaming tables, ......more.
|Barley's Casino & Brewing Co.
|Barley's has 199 slots and video poker, a sports book and a 24/7 brew pub. The Las Vegas Weekly's Mark Adams recommends having the signature brew, Red Rock Oktoberfest Lager, to wash down a slice of wood-fired pizza. The Brickhaus Pizza Kitchen offers wood-fired pizzas and is open Sunday through Thursday 11 a.m. to 9 p.m. and Fridays and ......more.
|Bellagio Resort and Casino
|The Strip and Nearby
Inspired by the beautiful villages of Europe, the AAA Five Diamond Bellagio overlooks a Mediterranean-blue, 8 ½-acre lake, where fountains perform a magnificent aquatic ballet choreographed to music and lights.
Within Bellagio are award-winning dining experiences including two AAA Five Diamond restaurants, Julian Serrano's Picasso and Le Cirque from the renowned Maccioni family.
Bellagio is home to an ......more.
|Big Dog's Cafe and Casino
|Central Las Vegas
|Traditional favorites and items like salads, pasta, Wisconsin bratwurst, walleye and steaks. More than 20 beers and Big Dog's Brews on tap. The Las Vegas Weekly's Mark Adams says the brewer's pick is the Red Hydrant Ale, experienced with an order of cheese curds....more.
|Binion's Gambling Hall
Binion's Gambling Hall has been a landmark in downtown Las Vegas for more than a half a century. The 80,000 square foot casino opens up to Fremont Street Experience and features 80-plus gaming and poker tables and about 800 slot and video poker machines.
Benny's Bullpen Sports Bar and Cigar Lounge is an old fashioned saloon featuring a full-service ......more.
|Boulder Station Hotel and Casino
Boulder Station, which has the look of a traditional western train station, is on Las Vegas' "Boulder Strip," or Boulder Highway, adjacent to Interstate 515/U.S. Highway 95. It offers 300 rooms that were all renovated in 2011, dining options, a 75,000-square-foot casino and a special area just for kids.
The casino provides offers more than 1,400 slots and video ......more.
|Buffalo Bill's
|Buffalo Bill's is located in Primm Valley, 48 miles southwest of the Strip. From the buffalo-shaped swimming pool to the resort's roller coaster to the casino floor, Buffalo Bill's has something for everyone. The 40,000-plus square foot casino includes games like blackjack, Caribbean stud poker, craps, keno, Let It Ride, Pai Gow poker, roulette, slots, Big Six Wheel, Texas Hold ......more.
|Caesars Palace
|The Strip and Nearby
Transport yourself to the opulent and excessive Roman Empire at Caesars Palace. But the ever-changing Caesars Palace is far from ancient. The hotel and casino is constantly raising the bar for what visitors can expect in a Vegas resort experience.
Caesars Palace features 3,348 rooms and suites in five towers, including the new luxury boutique Nobu Hotel and Restaurant, more.
|California Hotel and Casino
The California Hotel and Casino is located a block away from the Fremont Street Experience and offers affordable rooms, gaming and dining options.
The hotel-casino was built to pay tribute to the 31st state, California, but has become an unofficial tribute to the 50th state — the property is often a stop for Hawaiian visitors. The Aloha Specialties restaurant ......more.
|Cannery Casino & Hotel
|North Las Vegas
Cannery Casino & Hotel's theme is a 1940's factory, evoking a post-World War II feel of industrialism, complete with a signature 120-foot-tall smoke stack.
Cannery Casino & Hotel features 201 guest rooms; a 72,000 square-foot gaming area with nearly 2,00 slot/video poker machines, tables games, live poker, sports book; and The Club, a 6,700 square-foot indoor and over 20,000 ......more.
|Casino Royale
|The Strip and Nearby
|The Casino Royale Best Western Plus offers guests a unique experience on the Strip. Drinks are inexpensive, room are affordable and table minimums are low. Squeezed between the Venetian and Harrah's, and across the street from the Mirage, the 17,500-square foot, 152 room hotel/casino offers a central location and a less-expensive alternative for those looking to have fun on the ......more.
|Circus Circus
|The Strip and Nearby
The hallmark of the 3,767-room Circus Circus Hotel, Casino and Theme Park in Las Vegas lies under the Big Top, where circus acts perform on the Midway Stage as part of the world's largest permanent circus.
The Adventuredome, America's largest indoor theme park, offers five acres of climate-controlled fun for all ages.
Guests of Circus Circus may dine in ......more.
|Clarion Hotel
|The Strip and Nearby
|The Clarion Hotel (formally the Greek Isles Hotel and Casino) is located two blocks west of the Las Vegas Convention Center. A 7,000-square-foot slot casino includes games such as Megabucks, Wheel of Fortune and Jeopardy. Guests who desire time away from the casino can soak up the sun at the resort's pool....more.
|Club Fortune
|Club Fortune Casino has more than 34,000 square feet of gaming space featuring 560 gaming machines and 12 gaming tables: four poker, five blackjack, one Pai Gow, one craps and one roulett. With two different dining venues, two bars and an entertainment lounge, there's always something interesting going on....more.
|Cosmopolitan of Las Vegas
|The Strip and Nearby
The Cosmopolitan of Las Vegas dares to be different. From the hotel's red reservations desks to fine art found throughout the resort, The Cosmopolitan's signature style is helping to pave its own path on the Las Vegas Strip.
Upon entering the resort, you're greeted by pillars of video boards playing video art by Digital Kitchen and David Rockwell Studio exclusively ......more.
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text:
So if you want to see us, you better move your rear, dear, before the show is sold out. A lot of folks have worked very hard to put this show together. I can't quite put my finger on it, but I get the impression that your boredom is a reflection of a lack of intellect, and that is certainly not my thing. Maybe, then, you should look for some geek with skinny jeans and nerdy glasses.
lol.. this guy.
lol.. this guy.
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text:
Monday, November 15, 2010
An Article in Waiting
I finished up a house history article today for my local newspaper.
At the outset it looked like it would be a fairly straight forward project. I did my own deed research and there was also some other information from previous researchers.
But this project proved to be troublesome. Two researchers had done some previous deed research on this house. One was a valiant effort by an inexperienced researcher that contained a number of gaps. The other research was very good and I recognized that it was done by a friend of mine. But unfortunately it only addressed the very early deeds.
My own research had a similar gap that I found frustrating. Why couldn't this one deed transfer be reconciled?
I could have written the article without resolving the conflict but it was nagging me too much. I felt uncomfortable writing an article that I didn't feel 100% concrete about. I felt I needed to know that my research was solid before I could see it printed in the paper.
So I headed over to town hall and went through the original tax valuations year by year. That told me definitively who owned the property and when. That made it easier to head back to the deeds. Problem one solved.
To deal with the other issue with the same house history, I scoured maps until I was satisfied I understood who was in the property and when. But it turns out that I really resolved all my lingering doubts my broadening my scope and turning the project into a genealogical project focusing on the whole family. When I understood the dynamics of the greater family relationship I was able to finally understand the history of the house.
In this particular case, the father owned and lived the family homestead. He also owned a smaller property that is the target of my research. He sold the property I'm researching to his oldest son in 1862. I discovered that he sold his homestead property to his other younger son the same year. Knowing that the oldest son was a boot maker while the younger son was a farmer like his father made all the difference. Suddenly, the division of these properties made sense.
I feel slightly crazy for being so stubborn about not writing the article until I really felt I had resolved the problem and understood the answer. I made my deadline but I spent hours more than I should have. It's just that I'm uncomfortable putting something into print that I can't absolutely stand behind.
Hopefully at least one of you out there will be able to relate to what I'm trying to say.
5 comments:
I think you did the right thing - research until you get the answer - not being a house historian, yet (your recent talk gave me the house history bug) I think I would have to fill in the gaps before putting it in black and white. Give us the link when it is published.ReplyDelete
I like how you "worked the problem" and utilized the different resources to build your discovery.ReplyDelete
I'm sure I would have a hard time holding back from doing the same thing every time!ReplyDelete
Not a bit crazy - exactly the right thing to do, I think. I once researched the history of a house we lived in in Boston - we rented the top floor and our very odd landlords lived on the main floor (the wife was the original owner). I couldn't publish it though, of course!ReplyDelete
- AnonymousApril 28, 2011 at 3:03 AM
Love your blog...just found it tonight. I'm researching a house for pay as I type this. Been working on it for over 2 months now. I could use the info I've gathered so far and make it work but when you know there's more to learn you do a great disservice to yourself and those who are interested. As a historian you commit a big fat sin by not going the distance conclusively. Nice to read that you felt the same.ReplyDelete


text:
Celiac disease is an autoimmune disease characterized by an inappropriate immune response to gluten, a protein found in wheat, and to related dietary proteins in rye and barley. This response leads to inflammation of the small intestine and to damage and destruction of the villi that line the intestinal wall.
The villi are projections, small tissue folds that increase the surface area of the intestine and allow nutrients, vitamins, minerals, fluids, and electrolytes to be absorbed into the body. When a susceptible person is exposed to gluten, the person's body produces an immune response. Immune cells cause damage to intestinal villi and immune proteins called autoantibodies may be produced as well.
As long as the person continues to be exposed to the proteins, that person will continue to produce an immune response and autoantibodies. When villi are damaged or destroyed, the body is much less capable of absorbing food and the affected person begins to develop symptoms associated with malnutrition and malabsorption.
Found throughout the world, celiac disease is most prevalent in those of European descent. It occurs in about 1 out of every 100 to 150 individuals in the U.S. and is somewhat more common in women than in men. It can affect anyone at any age but occurs more frequently in infants and in those in their 30s and 40s. Celiac disease was once common only in infants and was very serious. Demographics of the disease have changed over time and it is now seen more often in adults.
The development of celiac disease is due to an inherited disorder that is thought to be triggered by an environmental, emotional, or physical event, although the exact mechanism is not fully understood. According to the National Digestive Diseases Information Clearinghouse, about 4-12% of first-degree relatives (parent, sibling, or child) of a person with celiac disease will also have the condition.