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My client was sitting in front of me, holding back tears. "I am just SO frustrated and fed up with this pain! I feel like you haven't made any progress on me"
I winced. Those words hurt.
I took a few deep breaths before diving deep into questions with her.
Over the next 15 minutes, we clarified exactly what was so frustrating, how the pain is affecting her & developed a game plan.
Old me would have freaked out. Panicked, gotten her right up on the treatment table & would have tried to throw every possible treatment at her.
And it would have failed.
Wiser me was able to stop, assess & get a clearer picture of what was really going on.
This was only her 4th session after 4 months of pain, which she ignored. She also had almost a month lapse between her first 2 sessions, and then was not compliant with her home exercises.
And…when I took the time to ask, I realized her original 9/10 pain was now at MOST a 5/10, and she no longer was limited in reaching a high shelf.
No progress!?? This was tremendous progress!
I also asked her what her alternative was. She didn't have one.
Through some questions, I discovered what she thought she wanted was for me to give her something that would make things move faster. What she actually wanted was for me to do the work for her. To just make it go away.
In a round-a-bout way, she accused me of having answers & hiding them in order to keep making her coming to sessions. Which is a very hurtful thing to think. If I had this, I would be shouting it from the rooftops!!
Ultimately, it comes down to people who want to change, but are unwilling to invest in themselves. People I meet at a social gathering & want me to tell them how to heal their chronic knee pain – as if I had some secret weapon that you only get when you become a doctor of physical therapy – and only a few special souls will ever get to see.
And I used to try. I used to try to tell them everything that needed to be done. And it never worked.
Obviously. There is a reason people go to physical therapy for week after week. There is a reason my nutritional therapy sessions come in a 3 month package.
There are no shortcuts. There is no way to teleport to our destination (and least not yet!).
Along the way, we may find solutions that feel like we are on a bullet train to our destination & make huge progress in short periods. Other times, it feels like we are trudging through a thick swampland to get there. But we can keep moving forward. And sometimes we may need to sit and wallow in the mud, and that is okay, too!
One absolutely key stop on this road is self responsibility. Sure, I show people how to take control of their health & guide them to healing physical pain – but all I am is a guide. I cannot do it for them. In some cases, them just showing up and being open to receiving the help is enough. In those cases, it is often because they have already certain stops on their journey & have taken ownership of the healing process.
In other cases, much larger shifts need to happen. For my 56 year old client, this was the case.
It didn't take long to begin creating significant shifts – she was ready for her shoulder pain to get better once she understood I wasn't hiding a magic cure. In that session, we were able to do more exercises & improve her pain exponentially.
But it isn't the end of the road for her.
Her body has been crying out for help for years. She has poorly managed Celiac disease, poor oral health, skin issues as well as tendencies toward anxiety & depression. Luckily, she is starting to listen.
While we may be able to decrease her shoulder pain, it is likely that another body part, organ or system will start screaming soon, too.
This doesn't mean we can't utilize some quick fixes as needed. But ultimately, for true healing & health, there are no shortcuts.
ALL aspects of health need to be addressed: nutrition, movement, sleep, spirituality, mindset, clearing past traumas & having joy. And this is GREAT news….because if you haven't reached your goals & are feeling stuck – there is LOTS to look at other than just food & exercise!!
But be wary of shortcuts. Or at least be very aware of that is what they are.
If you've found yourself guilty of thinking someone has a magic area (<— OOH, I HAVE!!!!), then it is time to step back & re-evaluate where you are on your journey. Then pick a thing from the essentials listed above that seems the EASIEST to address, and start there, with one little baby step.
Not quite sure how? Don't hesitate to schedule a FREE consultation with me & I can help guide you!


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Project Manager – RC Frame Contractor
- £70,000 - £90,000 Per Annum / £300 -£400 Per Day
- Civil Engineering
- London
About the Company
Having been established for over 30 years with in the specialist field of concrete frames and groundworks, this business is without doubt one of the leading names with in this field. Current turnover is around £175m per annum across all of their divisions and this has progressed steadily year on year going back over the last decade. They currently complete packages ranging in value up to £60m each on a mixture of residential, commercial, educational and leisure projects throughout the London area.
The business prides themselves on their high repeat business rate and their in-house capability to take complex projects from design through to completion. They are family owned and still maintain the family feel they have had over the last 10 years I have known them, which is important, because not all do as they grow. I would highly recommend this business as a polished environment where individuals can grow and flourish working on some of the best projects in London and it is worth pointing out, I have never had anyone leave this business that I have placed there.
About the Opportunity
We have been asked to find specialist groundwork and concrete frame Project Managers capable of delivering packages ranging in value from £2 million up to £6 million each.
This is an exciting opportunity to lead and motivate your team to exceed goals whilst keeping to budget and to programme. The successful professional will receive the necessary support and guidance from the senior management team. You will also be given the autonomy and responsibility to achieve results using your own management style and methods of leading site teams.
This specialist contractor carries out a variety of complex packages with technical challenges to overcome. You will work closely with the contracts manager to deliver these residential and commercial packages to the highest standards.
About the Requirements
Construction professionals will need be degree qualified in civil engineering or construction management and will be able to show a strong career history from a site engineer level through to management over the last 5-10 years. Individuals will need to have a strong understanding of everything from piling, groundworks, basement construction and concrete frame construction, whilst working on both residential and commercial projects.
Usual duties will apply from overall management of the site team, technical management of the programme and works, through to management of the client and surrounding aspects (i.e. health & safety, temporary works and client meetings).
It is crucial that the individual can show a strong amount of concrete frame and groundwork construction background having worked for rival RC frame and groundwork subcontractors in the UK. You will ideally have experience of working in London and the South East. Candidates from a main contract or different subcontract background cannot be considered.
In terms of software, our client uses the usual Microsoft programmes, standard email functions and Asta Powerproject for planning / programming works. Project Managers will be required to use all these tools.
About the benefits and rewards
For this exciting opportunity, we are targeting professionals looking to earn anywhere from £70,000 to £90,000 per annum however specific salary will be defined upon experience and suitability. Furthermore, there will be a generous package offered; travel allowance OR company vehicle in addition to standard benefits associated with a successful company (bonus scheme, pension, laptop, phone etc.).

subset: commoncrawl


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Cancer is increasingly apparent as a systems-level, network happening. The central tendency of malignant alteration can be described as a two-phase procedure, where an initial increase of network plasticity is followed by reducing plasticity at late stages of tumor improvement. Cancer stem cells (CSCs) are cancer cells that take characteristics associated with normal stem cells. Cancer therapy has been based on the concept that most of the cancer cells have a similar ability to separate metastasise and kill the host. In this review, we addressed the use of nanotechnology in the treatment of cancer stem cells.
Progress in preclinical and clinical cancer research has brought new diagnostic and therapeutic options for cancer patients that would provide significant improvements in the treatment and prevention of cancer (1). The most life-threatening aspect of the cancer is metastasis that spreads cancer cells from their original tissues to other ones (2). Cancerous tissues include collections of heterogeneous cell populations that are different in their apparent state of differentiation (3). These heterogeneous populations contain particular types of "tumor-initiating" cells arisen from mutations of normal stem cells (4). Stem cells are undifferentiated cells which were found in multi-cellular organisms. They have three main properties including differentiation, self-renewal, and homeostatic control (3). Accordingly, tumor-initiating cells were called "cancer stem cells" that have the capacity for self-renewal, being able to differentiate into any cell, and the proliferative ability to expand malignant cells (4). Although the exact cause of cancer is unknown, the understanding of the balance between self-renewal and differentiation is an essential way to prevent cancer formation and the therapeutic utilisation of stem cells in human diseases. Current cancer therapies including radiotherapy, surgery, and chemotherapy intend to destroy or kill every cell of the body (5). Cancer stem cells (CSCs) do not destroy easily with conventional methods of cancer treatment such as chemotherapy and radiation. Although, anticancer drugs can lessen tumor size, but do not kill cancer stem cells. Though CSCs might only create up a small part of a tumor, their resistance to drugs lets them persist. Therefore, the identification of tumor-initiating cancer stem cells (CSCs) is of significant interest in cancer research and suggests varied approaches (6). In the last few decades, nanotechnology and nanomaterials have found essential roles in cancer diagnosis and treatment for better early detections and also, more efficient drug delivery to the tumor cells. This review aims to highlight the opportunities and challenges for integrating the nanoscience with cancer biology and thereby, researches regarding the advanced nano-based detecting systems for cancer stem cells.
Cancer is defined as a biological condition with an uncontrolled division of the natural body cells. Until now, the complete treatment of cancer as a disease is difficult and costly. One reason for this difficulty relates to the presence of specific receptors on the surface of the cancer cells that pump the drugs out of the cells. Therefore, it is difficult to find a drug to eliminate these cells. However, all cells involved in tumor development are not equally dangerous. The leading cause of cancer is a group of dividing cells with high power and high resistance to the drugs that they called CSCs. CSCs are the cells in tumors or blood that are known particularly with the ability to turn into all cell types that are found in the host body. CSCs were identified and characterized in the 1990s, when a stem cell biologist, John Dick, said that his team had isolated scarce cells in the blood of people with leukemia that seemed to have a crucial role in cancer (7). Most researchers believe that CSC, in addition to leukemia, exists in solid tumors such as prostate, breast, and pancreas cancers. They can renew and keep themselves in the tumor masses (8–10). CSCs differentiate into several types of cells through the renewable process that can be the reason for the tumor formation. Such tumor cells as a distinct population remain and cause the disease to recur, metastasis and tumor development.
Some of the characteristics of the CSCs are similar to normal stem cells. These cells have extraordinary capability of self-renewal, differentiation and proliferative potential. The CSCs have been identified in tumor tissues and cell cultures by detecting the expressions of specific protein markers, such as CD133, CD44 and CD24 (11–13). Table 1 shows the markers of cancer stem cells in a variety of solid tumors (6, 10, 12, 14–31). The CSCs have the potential to be adapted to different environments. Therefore, the high flexibility of the CSCs can be used as a high potential for changing the plasticity and rigidity of their network (32). Environmental changes would often be strong enough for increasing the tumorigenicity of cancer stem cells (33). Generally, studies and trials have shown that the CSC self-renewal potential is determined by the high proliferative potential with a loss of regular differentiation program and high efficiency in response to environmental changes. The CSCs have two main phenotypes include the proliferative and quiescent state that characterized by symmetric and asymmetric cell divisions. The cancer stem cells with proliferative phenotypes have symmetric cell division and are less aggressive and could be classified as a plasticity network (34).
On the other hand, the CSCs with the quiescent phenotype have asymmetric cell division with dynamic properties and are classified as a rigid network (35). The CSCs with quiescent phenotype may be the main factor in the metastasis that would appear years after surgical treatment of a primary tumor. Protection of the CSCs against therapeutic agents and their resistance to the treatment process can be obtained by, quiescence, expression of ABC (ATP-binding cassette) drug pumps, increased expression of anti-apoptotic proteins and resistance to DNA damaging agents (Fig. 1).
It can be concluded that the tumor cells without the CSC marker would be killed by chemotherapy, resulting in tumor regression, but the cells with the CSC markers are resistant to the treatment and their number would be risen in a tumor (36–38). Surface markers of the CSC, in many types of cancers, are shown in Table 1.
The percentage of CSCs are different in many types of cancers (39, 40) and there are relations between the number of CSCs and patient prognosis (41, 42). Studies have demonstrated that cancer therapy could target the tumor cell mass and create a partial regression of a tumor, but the CSCs could make and develop new tumor clones, therefore, identification and directed targeting against this kind of stem cells have been reported to be more effective (Fig. 2) (40, 43). Cancer therapy, based on this hypothesis, was reported to decrease mechanisms of resistance to conventional chemotherapeutic drugs and radiation therapy. The new design of cancer therapeutic drugs could eliminate the CSCs by interfering with the specific pathways (44–48).
Scientists and researchers have suggested that comprehension of disorders in signal pathways or too much activation is one of the most vital importance for anticancer targeting of the CSCs. Wnt, Notch and Hedgehog signaling pathways have critical roles in the reappearance and maintenance of cancer stem cells (49). Wnt marks a group of signaling proteins that bind to surface receptor molecules on the target cells. Activation of Wnt target genes happens by
Notch signaling pathway has a critical role in the cell-fate decision, tissue patterning, morphogenesis (51), and maintenance of the glioblastoma and breast cancer stem cells (52). A reported study about Notch signaling pathway suggested that Notch inhibition in glioblastoma could decrease cancer stem cells via an endothelial cell intermediate (53).
Studies have suggested that the Hedgehog (Hh) signaling can regulate many cancer stem cells including glioblastoma, pancreatic adenocarcinoma, breast cancer, multiple myeloma, and chronic myeloid leukemia (CML) (20). Hh signaling has been found to play multiple roles in development, homeostasis and disease by activating the 7-pass transmembrane protein Smoothened (Smo), to send an intracellular signal. Due to that, the most advanced types of Hh antagonists are Smo-targeted (54, 55). Targeting the signal pathways including the Wnt, Notch, and Hh may improve current strategies for cancer therapy. Although, anti-cancer treatment can reduce tumor size, survived CSCs would trigger tumor formation again. This type of relapse causes metastasis and more resistant to treatment. Therefore, most currently available cancer treatments such as hormone therapy, radiotherapy and chemotherapy, would not be useful in the elimination of cancer stem cells (5). Specific targeting of tumor stem cells has been suggested to be an efficient alternative for cancer treatment (10, 11).
Today, cancer mortality is one of the most common causes of death. The application of nanotechnology in medicine includes six areas including 1) detection of molecular changes in diseases; 2) diagnosis and imaging; 3) drug delivery; 4) combined therapeutic and diagnostic applications; 5) report of therapeutic agent efficacy; and 6) nanotechnology applications in scientific discovery and basic research (56). A variety of nanostructures from organic and inorganic materials have been recently used for cancer therapy and diagnosis in passive or active tumor targeting. A novel formulation of nanovesicles, liposomes, polymeric micelles, dendrimers, and polymeric nanoparticles can enter into the solid tumor site through the porous structure of a tumor vascular system, and then, selectively deliver the therapeutic agents (57, 58). Nanomaterials with proper targeting ligands could bind to antigens or receptors on the target cells. However, this powerful technology leads to a decreased toxicity in non-targeted cells, and therefore, the distribution of nanomaterials will be increased in the target cells (59). Some of the nanomaterials shown in Table 2 (60–73) such as semiconducting nanoparticles or quantum dots (QDs), colloidal nanoparticles, dendrimers, magnetic nanoparticles (MNPs), carbon-based nanomaterials (CBNs), and liposomal nanoparticles systems have been constructed for utilization in therapeutic applications. Quantum dots (QDs) are semiconducting nanoparticles with the diameter ranging from 2~10 nm, narrow emission and broad absorption profile, high photostability, long fluorescence lifespan, ability to be conjugated with proteins (74). Also, QDs have the potential of applications in molecular and cellular labelling, cell tracking, drug delivery and also, cancer detection and therapy (75, 76). Dendrimers are highly branched synthetic polymers (about 1.5~13.5 nm) (77, 78) that have attracted considerable attention because of their hyper-branched structure, monodispersity, functional surface groups, and symmetrical conformation (79).
Furthermore, they have various types of core molecules, such as ethylenediamine, cysteamine, diaminobutane, carbohydrate, calixarene, etc. and functional surface groups like amino, carboxyl, hydroxyl that give the opportunity to modify their surfaces with biomolecules (80). Polyamidoamines (PAMAMs) are the most widely studied dendrimer because of the polycationic properties that can have interaction with charged molecules (81). Gold nanoparticles (GNPs), with diameter size of 0.8 to 200 nm have been used for imaging, targeting, drug delivery, and therapy applications. Biological molecules can be readily attached to the surfaces of the GNPs. Binding of molecules including biotin, peptides or oligonucleotides enhances cell penetration efficiency of the nanoparticles. Surface plasmon resonance of GNPs is used to many applications such as hyperthermia (82). Superparamagnetic NPs (SPIONs) are small synthetic particles of iron oxides with a core size of 0~10 nm. They show new magnetization behaviour totally like standard paramagnetic materials, but with, high field irreversibility, high saturation field, additional anisotropy contributions or shifted loops after field cooling (83, 84). Also, after eliminating the magnetic field, they do not show magnetic interactions (85). The SPIONs well-dispersed in a liquid and especially in water have drastically increased their biological and medical applications in recent years. Applications of SPIONs are diagnosis, therapy, and drug delivery system; Moreover, recent systems are used on stem cell differentiating/tracking (85, 86). Carbon-based nanomaterials (CBNs) are one of the most widely used tools in the fields of biomedicine, biotechnology, environment, and electronics (87, 88). CBNs with excellent physical, mechanical, electronic, and biological properties are engineered by using graphite, in different types of graphene, fullerene, and single- or multi-walled CNTs (89). Besides, modification of CBNs with biomaterials have been utilized in imaging, delivery systems, targeted therapy, tissue scaffold reinforcements, and bio-detection systems (90). Liposomes, as the most clinically established nano-scaled platforms, are merely formed from phospholipids and cholesterol by a self-assembling method in aqueous media in a variable size distribution from 20~1000 nm (91). The most application of liposomes is in drug delivery systems in which encapsulated drugs could be protected and directly delivered to the cells within lipid bilayers (92). Fig. 3 demonstrates the various nanomaterial that targeted cancer stem cells.
The CSCs are believed to drive tumor growth and be highly resistant to conventional therapies (e.g. chemotherapy and radiotherapy) and lead to disease relapse and the formation of metastases. Therefore, there is considerable interest in the use of nano-sized materials for CSC-directed anti-cancer therapies. The surface of nanoparticles has been designed to accurately and effectively target the CSCs (93). Identification of the CSC is possible by some markers, e.g. ALDH, CD44, CD90, and CD133, and specific signaling pathways, i.e. Notch, Hedgehog and transforming growth factor-
Aldehyde Dehydrogenases (ALDH) is a functional marker of the CSCs and also, the scavenger of reactive oxygen species (ROS) (97–99). Studies have been demonstrated that ALDH activity of converting retinol to retinoic acid increases in many cancers (100, 101), such as cervical cancer (102), non-small cell lung cancer (103), melanoma (104), and also is considered as a specific marker of BCSCs in breast cancer (105). Disulfiram (DS), is a specific inhibitor of the ALDH that have cytotoxic effects on a wide range of cancer cell lines including colon, breast and brain ones (106–112). However, its clinical application is limited due to very short half-life in the bloodstream. A study revealed that encapsulation of the by poly (lactic-co-glycolic) acid (PLGA) nanoparticles (DS-PLGA) causes longer circulating time in the bloodstream, and also, DS-PLGA/Cu combination manifests very likely synergistic cytotoxicity effect with 5-FU and sorafenib. Finally, the results suggest that nano-based controlled delivery system would make DS fast translation into liver cancer cells (97).
CD44 factor is one of the most popular and familiar surface biomarkers associated with cancer stem cells (113). Clinical studies have demonstrated the CD44 as one of the most critical proteins in tumor genesis, growth, metastasis, and chemo-resistant processes in a verity of tumors in colon, breast, head and neck, and pancreatic cancers cancers (26, 114, 115). Antibody-based cancer treatments, over-expressing CD44, represents the dominant anti-CSC approach specifically in BCSCs (116). In a study, active targeting and drug delivery to the breast and colon cancer cell lines was evaluated by biodegradable poly[(D, L-lactide co-glycolide)-co-PEG] (PDLGA-co-PEG) polymeric micelles loaded with paclitaxel (PTX) and functionalized with anti-CD44 antibodies. Evidence has shown that active-targeted PLGA-co-PEG-PTX micelles increase the intracellular concentration of PTX, and therefore, the effectiveness of drug delivery to the CSC (117). Arabi et al. (118) have demonstrated the selective drug delivery potential of liposomal doxorubicin functionalized with anti-CD44 and increased circulation time, biodistribution and therapeutic efficacies of CD44-Doxil compared to the non-targeted liposomal formulation and free drug. Magnetic NPs (MNPs) with anti-CD44 antibody have also shown the potential selective treatment of CD44 positive cancers such as pancreatic and breast cancers cell lines (119).
As mentioned before, the CSCs can be identified by detection of the CD133 expression as a stem cell marker and also, is explicitly regarded as a marker in osteosarcoma. The potential of CD133 targeting for drug delivery to the CSCs in osteosarcoma has been examined previously. It is illustrated in a study that Poly (lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers would deliver salinomycin specifically and efficiently to the CD133+ CSCs in osteosarcoma and kill them (120). In another new form of drug nanocarrier, mesoporous silica nanoparticles (MSNs) have been used to deliver both antitumor drugs and siRNA into CD133+ cancer cells. This formulation significantly improved the efficacy of therapeutic drugs in laryngeal cancer cells (121). Curcumin and some other natural chemopreventive agents have recently been shown to inhibit the CSCs, but with low bioavailability.
Furthermore, various nanotechnology-based formulations of curcumin have been recently evaluated as well. Preparation of the nanoscale drug delivery systems has been considered as an innovative approach to overcome the bioavailability and stability issues. For instance, it has been shown that a polymeric nanoparticle (made by mixing N-isopropylacrylamide, vinylpyrrolidone, and acrylic acid in a molar ratio of 60:20:20) encapsulating curcumin, named "nanocurcumin", can inhibit brain tumor cell growth and deplete CD133+stem-like cells (122, 123).
Another major pathway involved in the CSC regulation isNotch signaling pathway that controls cell-fate determination during development and maintains adult tissue homeostasis (124). This pathway could lead to the development of many cancers including melanoma, medulloblastoma, rhabdomyosarcoma, basal cell carcinoma, breast, lung, liver, pancreas, and prostate cancers (125). Fan et al. (126) examined the effects of Notch pathway inhibition on the growth and xenograft formation of medulloblastoma. They found that Notch blockade results in the growth of tumor cells and tumor-forming capacity, due to the depletion of stem-like cells. Clinical application of Notch inhibitors,
CD90 is glycosylphosphatidylinositol (GPI) anchored glycoprotein that is expressed in leukocytes, bone marrow-derived mesenchymal stem cells, hepatic stem/progenitor cells (HSPCs) and also, is identified in murine breast CSCs. Studies have shown that CD90+ cells have tumorigenicity and metastatic potential (129). 90% of blood samples from liver cancer patients contained CD45−/CD90+ markers (25). Bakalova et al. (130) have utilized CD90 as a valid therapeutic target They have shown that photosensitizer trifluoperazine loaded in anti-CD90 antibody-mediated water-soluble CdSe core nanocrystals could be delivered directly to the CD90+ leukemia CSCs where it could cause leukemia CSCs sensitivity to UV irradiation and apoptotic cell death.
It is known that the Hh pathway helps in controlling cell growth and morphogenesis. The components of the Hh signal transduction pathway can control embryonic development and also, is expressed in postnatal and adult tissues. These components have assigned roles in the maintenance of stem cells and tissue repair (131). At least three Hh gene homologs have been identified in human: Sonic Hh (SHh), Desert Hh (Dhh), and Indian Hh (Ihh), among which SHh is the most widely used one (132). Hh ligand can bind to the 12-transmembrane receptor Patched 1, which relieves seven-pass transmembrane receptor named Smoothened (Smo) from repression and allows downstream activation of the pathway through the translocation of GLI, where it acts as a transcription factor to the nucleus with the mediation of SUFU and KIF17. High expression and aberrant activation of Hh ligands present in the majority of human cancers including brain tumors, melanomas, leukemia's, gastrointestinal, malignancies of the breast, ovary, prostate and, pancreas cancers (133). Therefore, targeting the Hh signaling pathway may provide a practical therapeutic approach in the treatment of various cancers. GLI inhibition through PLGA-PEG nanoparticles (NanoHHI) has illustrated tumor growth inhibition and antimetastatic effects in hepatocellular carcinoma (HCC) models (134, 135). In another study, the effects of anthothecol-encapsulated PLGA-nanoparticles (Antho-NPs) have been examined on the behaviour of pancreatic cancer stem cells (CSCs). They have discovered that Antho-NPs inhibited the CSC proliferation and induced apoptosis by disrupting GLI-DNA binding and also, it acts as GLIinhibitor. Using PLGA nanoparticles offers many benefits of appropriate stability in physiological environments, entering to a cancerous sphere without any auxiliary reagents, loss of toxicity towards human pancreatic normal cells and PLGA-NPs could cross the blood-tumor barrier (136).
The cancer treatment needs the improvement of approaches which can efficiently eliminate cancer and amend the application of this novel drug-delivery modality (nanomedicines) (149, 150). Recently, researchers have been interested in the nanotechnology-based drug because these drugs are most useful for developing anti-cancer therapies and CSCs targeting. There is some clinically approved nanomedicine include Pegylated liposome (Doxil), Albumin-bound paclitaxel particles (Abraxane), Iron oxide nanoparticles (NanoTherm), PEG-1 Asparaginase (Oncaspar), Methoxy-PEG-poly (d,l-lactide)-paclitaxel micelle (Gene-xol-PM) and SMANCS (Zinostatin) (151). Considering these issues that mentioned the nanotechnology-based anticancer drug helps treat and prevent various types of cancers because these drugs have excellent diffusion capacity, selective killing of tumor cells or CSCs. Also, CSC-targeting with nanomaterials is in the early stages because these studies have done in vitro and in vitro phase only. So a vast amount of detail in vitro, in vivo and other relevant information, is essential that these nanomedicine products have a clinical practice. The other important issues are the safety, effective dosages and side effects of nanomaterials used in drug delivery systems which should be given special attention (152).
Finally, the most important thing is that the treatment of cancer using nanotechnology is helpful approaches for cancer patients because most of them suffer from chemotherapy and radiotherapy. Moreover, CSCs targeting with nanomaterial may present a novel method for reducing the costs on the public health care system.
The basic cause of cancer is a group of dividing cells with high power and high resistance to the drugs that they called Cancer Stem Cells (CSCs). CSCs were identified an characterized in the 1990s, in the blood of people with leukemia that seemed to have a vital role in cancer. CSCs are markedly resistant to conventional cancer treatments, such as chemotherapy and radiation. Therefore, understanding tumor biology is critical for the development of successful therapies. Identifying and selectively targeting markers and signaling pathways of CSCs are new therapeutic strategies for cancer treatment. The current success in the fight against CSCs has been reported in studies that using nanotechnology-based therapeutics with using different surface markers and biochemical assays for identification. Based on nanomedicine studies mentioned in our review, it is shown that nanomedicine in the treatment of CSCs can provide additional benefits for cancer patients with fewer drugs side effects such as, increasing their cellular uptake, prolonging systemic circulation, improving biodistribution profiles, and resolving problems of poor stability and solubility. This review has shown bright prospects of cancer treatment by nanomaterials, and specifically nanoparticles with increased therapeutic potency in drug delivery, CSC specificity and fewer side effects.
The authors thank the Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences for all the support provided.
The authors have no conflicting financial interest.


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Theme – A Bridal-shower theme is a way of designing a party around a certain subject, time in history, or part of the world. Bridal shower themes are as varied as the brides themselves and add a specific ambiance to the party. Once you have chosen a theme, the rest of the shower planning becomes easier because invitations, decorations, and favors can all be coordinated to fit the theme. . Whether the bridal shower theme is part of the wedding or unique event that the friends of the bride put together and creates inspiration and a more magical environment. There are so many themes from which to choose. Some of the most popular are: kitchen shower, exotic locale, the bride's favorite pastime, using the bride's heritage, plan a shower with her favorite ethnic foods, or stock the bar. A Halloween themed bridal shower can be a fun and inventive way to celebrate the bride-to-be, as long as the event does not scare her away from the altar! Use your imagination to create the perfect theme.
As hectic as planning your wedding might be, it is of utmost importance that after the shower has been given in your honor, you set aside some time to send bridal shower thank you cards. Preparing for the wedding can be overwhelming to say the least, so when close friends of the bride get together and throw a bridal shower for the sheer purpose of pampering you in preparation for what lies ahead, and as tired and tense as you might be, you must acknowledge your friends and loved ones with appreciation for all their efforts, and the lovely gifts they gave.
The Custom – The underlying reason for a Bridal shower is that it's a perfect occasion for family and friends of the bride to spend relaxed time with her before the big wedding day. A Bridal shower is commonly hosted by the maid-of-honor and bridesmaids or friends and family of the bride or groom. The custom is said to have grown out of earlier dowry practices when a poor woman's family might not have the money to provide a dowry for her, or when a father refused to give his daughter her dowry because he did not approve of the marriage. Another custom was to help the new couple set up a home, or to help the bride get together a trousseau. The Bridal shower kicks off the wedding festivities and it is important that everything goes well.
Getting Your Bridal Shower Invitations Out on Time – You want to make sure that your bridal shower invitations are put in the mail with plenty of time for your guests to respond and for you to get a clear count on your guest list. A good time frame for mailing is 2-3 months prior to the bridal shower.
A bridal shower is a fun way for a friends and family to celebrate her, prior to the wedding whether it is an afternoon luncheon party, a spa retreat, or night on the town, the Bridal shower is always a highly anticipated part of the wedding festivities. Throwing a bridal shower is the perfect way to show the bride how much you care and is a great opportunity to create wonderful, long lasting memories with friends and family.
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Manic-depressive leaders are great in a crisis, refusing to bow to adversity. They rush in where others feared to tread and can inspire others to follow. The downside is that due to their extreme sense of empowerment, energy and optimism, their thinking and judgment can be flawed. This blog entry with the Harvard Business Review explore the manic-depressive leaders, who, caught up in their grandiosity, may overestimate their capabilities and try to do more than they can handle.
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This article explores the options available to anyone who has to manage a bad boss. Much of it will feel like common sense. But people often forget that it's in their power to improve bad situations, so having the options systematically laid out can be very helpful.
Published on 1 Dec, 2016
In this book of insightful essays, Kets de Vries explodes the myth that rationality is what governs the behaviour of leaders and followers and provides a more realistic perspective on organisational functioning and the leader-follower relationship.
Published on 13 Aug, 2003


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Does Medicaid Spur Opioid Abuse?
Overdoses and hospital visits have grown far more in states that took the ObamaCare expansion.
Forty-one state attorneys general are investigating drug manufacturers and distributors for fanning the opioid epidemic; several have already sued. The allegation is that Big Pharma used deceptive marketing to hook millions of Americans on prescription painkillers, which served as gateway drugs to more potent opioids like heroin and fentanyl.
But government health-care programs are among the biggest suppliers of prescription painkillers. The attorneys general ought to be investigating how Medicaid may help promote opiate abuse...


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Jan 19, 2017 · What causing your digestive problems? WebMD explains how to treat and prevent heartburn, constipation, gas, bloating, diarrhea, and hemorrhoids.
Learn about these easy natural remedies to ease your acid reflux symptoms. These medications decrease the acid that is causing the reflux, but your stomach actually needs this acid to keep the rest of your body balanced. The acid breaks. You can also mix oatmeal, almond milk, and bananas for a powerhouse effect.
It can be a sign of overeating. If the stomach is empty for a long time, the acid starts acting on the stomach walls, causing a burning sensation. A prolonged effect may lead to stomach ulcers and may cause them to bleed. Hence,
Jordan Appel came by the show to discuss acid wear and how we can. determine the harm dietary acidity can do to your teeth. Canadians may be surprised to learn of some foods and drinks that are acidic. such as bananas, grapes, and.
Acid reflux or acid indigestion is a common digestive disorder that generally occurs when the stomach acid or its content flows back. Can Bananas cause Acid Reflux?
Feb 13, 2017. Use our checklist below to see if you have acid reflux. If there are no food proteins for it to break down (as there are in the stomach), the activated pepsin will instead eat away at the throat and oesophagus, causing problems from inflammation and heartburn to Barrett's oesophagus (a precursor to cancer).
That's why people grasp at their chest—The pain can literally take your breath away. Ouch! That's why Eat This has compiled a list of 28 foods that either cause or alleviate and/or prevent acid reflux from brewing. We'll start with the.
People with laryngopharyngeal reflux may feel as if they have something stuck in their throat. Laryngopharyngeal reflux can cause hoarseness. Examples of low-acid foods are melons, green leafy vegetables, celery and bananas. Foods.
After my diagnosis, the doctor told me to eliminate all fruit except bananas. GERD causes increased mucus, I clear my throat a lot, which is the worst thing you can do for singing. I wasn't misusing my voice; all the damage has come from.
Acid reflux happens when stomach acid leaks into the esophagus. When this happens, it can be very painful and feel like a burning sensation in your chest. Other symptoms of chornic acid refulx can include: regurgitating food, liquid, difficulty swallowing, coughing, wheezing or chest pain (1). Normally food passes through.
In Dropping Acid: The Reflux Diet. in groceries and health-food stores. Aloe vera can be used in. acid reflux. However, as with bananas,
It is possible that your diet could be making your reflux worse. Here are 7 healthy foods good for acid reflux that might help you find relief.
How To Treat Acid Reflux In A Newborn Frequent spitting up or vomiting in children is often due to acid reflux, also called gastroesophageal reflux disease (GERD). It can happen to infants as well as older. To decide whether your child needs treatment, you should know. Acid Reflux: When is it more than just spit up? – ChildrensMD – Oct 24, 2011. I
A drug commonly used to treat acid reflux is linked to a more than doubled risk of developing. The study concluded no firm cause and effect could be drawn, but doctors should "exercise caution when prescribing long-term PPIs. even.
Acid reflux (also known as GERD, or gastroesophageal reflux disease) is characterized by a burning sensation in the upper part of your stomach, right in the center of your chest near your esophagus. Before we get into the best foods for acid reflux, let's take a look at what could be causing this painful digestive condition in.
Foods that can bloat up the abdomen causing increased abdominal pressures that causes acid to reflux back up into the esophagus.These foods are: All carbonated. Miscellaneous. Vegetable soup, hummus, soups without GERD triggers (such as tomato), muffins, pancakes, banana smoothie and strawberry smoothie.
Gastroesophageal reflux is fairly common in dogs, and may occur at any age, although younger dogs are at greater risk. The gastric stomach acid, pepsin, bile salts, and other components of the gastrointestinal juices cause damage to the protective mucus lining the esophagus. This can result in inflammation of the.
If you suffer from acid reflux, you can find relief by adding these foods and drinks into your diet.
Silent reflux is a hard-to-detect condition that, left untreated, can turn into one of the deadliest cancers. Read on about the three steps you can take to prevent.
Why do bananas cause acid reflux? I am sorry that I cannot really answer your question, but it is a problem for about 1% of acid sufferers. Personally I can eat a.
How Does Digestion Work and How Can I Improve Mine? (Animated graphics)
Visit Renew Life® For Some Simple Tips to Help Prevent Heartburn & Acid Reflux.
Know More About Can Bananas Cause Heartburn, Everything You Need In One Place.
Can Bananas Cause Acid Reflux Food Against Heartburn with How To Solve Heartburn and Does Water Help Heartburn Natural Remedies For Acidity And Heartburn Heartburn At.
Are you at risk of gastritis? – Consuming hot or heavily spiced food, drinking alcohol, soda and other soft beverages, as well as excess consumption of tea and coffee are some of the things that can cause gastritis. to the acid in the stomach. Fresh milk, bananas, rice.
You can do it! Acid Reflux control is all about the diet. One should refrain from sugars, carbonated beverages, high acid fruits (lemons) and veg (tomatoes).
Some Food To Soothe Acid Reflux Agida Heartburn Can Bananas Cause Heartburn and Heartburn Cancer that Heartburn Tablet Condition
According to Lisa Griffiths, a homeopath at The Round Clinic on Hong Kong Island, anyone suffering from a stomach ulcer will slowly experience progressively worsening symptoms of heartburn, acid reflux and. These can cause the interior.
I have been how to buy viagra in philippines on your reflux diet for several months with excellent results. I've dropped over 22 pounds, feel energized, am sleeping.
As science discovers new ways to treat acid reflux, tradition has come up with several effective herbal remedies. These remedies are natural and commonly available in.
Acid reflux food to avoid for your baby suffering from infant reflux. Super important when starting them on blended or solid foods!
Oct 3, 2017. Best Foods To Beat Acid Reflux Naturally. Honey; Pumpkin, sprouted seeds, and radish; Potatoes and beet root; Green tea. Here are a list of foods that can beat the problem of acidity naturally. Incorporate foods that are non-citrus such as apples, bananas, and pears. You can have banana shake, muffins,
So, to make sure that your bedtime snack can be effective in promoting sleep. People with gastroesophageal reflux disease, or acid reflux, should be careful not to lie down within three hours after a meal. That might trigger symptoms.
Forget what you heard about an apple a day keeping the doctor away, try a banana instead. They are very good for acid reflux. Bananas contain a natural antacid to.
Six Common Foods That Contribute to Acid Reflux. "You can combine handful of berries and almond milk in a smoothie You can add banana, which cause the.
Nov 18, 2015. GERD can also cause symptoms that may not be obviously associated with the disease. For example, the stomach juices that leak out can get into your windpipe and make you cough, or attack your teeth. Other non-typical symptoms include a chronic cough, chest pain, asthma, laryngitis and tooth erosion.
Nutrition Plans for Morning Workouts. Working out in the morning gives you an energy boost and ensures that you get your workout done before your schedule gets in the.
Known medically and commercially as GERD, the acronym for gastro-oesophageal reflux disease, repeated bathing of the soft tissues of the oesophagus with corrosive stomach acid can seriously damage them and even cause oesophageal.
May 24, 2010. While there are many home remedies for acid reflux, knowing which foods cause acid reflux is your best bet from experiencing it in the first place. If you frequently get acid reflux, I would recommend you follow a healthy, alkalizing diet. This will help you take great strides in bettering digestive function and.
Cure Heartburn And Acid Reflux Stop Acid Reflux in About 60 seconds with Natural Old. – Stops Acid Reflux is a remarkably effective old Amish formula that stops acid reflux in about 1 minute. Stops Acid Reflux contains a very balanced mixture of. Proton pump inhibitors, also known as PPIs, are the first-line treatment for GERD. They reduce the production
The following home remedies for heartburn and indigestion can help to soothe, treat, and even prevent heartburn and indigestion altogether. Eat an Apple or Banana. 7. Administer a Gingerroot Tea. This condition can cause long lasting heartburn and indigestion, even without any of the above listed causes or triggers.
Just a few weeks earlier, 2-year-old Austin would eat only three foods — bananas. medicine can be given before the child starts eating regular meals. The same could be true with severe cases of reflux, with the child needing an acid.
A list of three widespread and Can Bananas Cause Acid Reflux unhealthy food combos was introduced at time you pray for your. Acid Reflux Bananas Cause Bananas.
Natural remedies for acid reflux like apple cider vinegar, baking soda, pickle juice and aloe are effective natural cures because they alkalize pH.
Q. Can you tell me how much acid is in bananas? My doctor told me not to eat them because they could cause acid reflux problems. I love half a banana in my cereal.
Bladder infection help!! This remedies looks so good, I have it now while posting. I'm in severe pain, I get this a lot, and frankly getting fed up.
Learn about gallstones (gall stones) diet and symptoms like biliary colic, constant pain in the middle or right of the upper abdomen accompanied by nausea. Gallstones.
Place beans and bay leaves in a saucepan with some water and bring to boil. Do Bananas Cause Acid Reflux reduce the heart pumps blood pressure is high.
Jan 2, 2018. Eating Tips to Stop Acid Reflux: Eat small meals. Don't eat three primary/large meals a day. Instead, frequently eat small amounts of food. This way, you're not putting too much effort and strain on your stomach. Don't overeat. Avoid fats. Do not eat anything with too much fat—these foods cause the stomach.
Try these ideas to help ease some of your symptoms: • Try to lose weight if you are overweight. Extra weight around your abdomen can put pressure on your stomach and this can lead to the reflux of stomach acid into your oesophagus ( gullet). • You should eat small, regular meals. Over- eating may make your symptoms.
If you find yourself blocked, a poor diet may be to blame. Eliminating these constipation-causing foods can help get things moving again.
Onset diabetes can cause suger control problems which damages the nerves in the stomach. This can cause gastroparesis, or delayed emptying of the stomach.
Acid Reflux And Morning Sickness Morning sickness and heartburn are probably among the most common inconveniences during pregnancy. The suffering can be lessened by these few, natural tips. For the first time, a large study shows that pregnant women who suffer morning sickness are not risking harm to their. which works by speeding emptying of the stomach and reducing heartburn,
Bananas cause acid reflux – Do bananas cause acid reflux? Acid reflux. Not really. Citrus fruits can cause reflux/ heart burn
Jan 19, 2017 · What causing your digestive problems? WebMD explains how to treat and prevent heartburn, constipation, gas, bloating, diarrhea, and hemorrhoids.
Silent reflux is a hard-to-detect condition that, left untreated, can turn into one of the deadliest cancers. Read on about the three steps you can take to prevent.
Compare Can Bananas Cause Heartburn and Get Acid Reflux Only At Night When Lying Down and Any Foods That Help With Acid Reflux Any Foods That Help With Acid Reflux.
What snacks to eat for better sleep – So, to make sure that your bedtime snack can be effective in promoting sleep. People with gastroesophageal reflux disease, or acid reflux, should be careful not to lie down within three hours after a meal. That might trigger symptoms.
Acid reflux, or heartburn, can happen when there is large amount of pressure in the stomach (such as after a big meal) or if the valve at the lower esophageal.
Jul 28, 2017. Do you suffer from frequent heartburn? Then you might have acid reflux. Try foods like bananas, oatmeal and yogurt to help manage the symptoms.
This includes adding in foods that help acid reflux like oatmeal, ginger and honey. Salad (sans certain fixins) and bananas are also considered useful on a diet for acid reflux. However, abstinence from some foods is likely even more important because many foods can trigger episodes. And, some of these foods are.
The esophagus, however, does not have the same protection, and if stomach acid and digestive juices reflux back into the esophagus, they can cause inflammation and damage to its unprotected lining. Heartburn is a burning discomfort.
Have You Tried The Acid Reflux Banana Treatment? | Ingredients for a Simple Life. There are different ways to treat acid reflux symptoms, regardless of the cause.
Causes of Acidity Eating spicy foods, lack of exercise, irregular eating habits, stress, or drinking alcohol frequently can lead to acidity. to neutralize the acid in the stomach. Eat bananas regularly to get rid of acid reflux completely and.
I have been how to buy viagra in philippines on your reflux diet for several months with excellent results. I've dropped over 22 pounds, feel energized, am sleeping.
If you suffer from severe or frequent acid reflux, also known as gastroesophageal reflux disease (GERD), you may be inspired to modify your diet. The.
Blood pH must be in balance (slightly alkaline) to prevent clumping of red blood cells so they can flow into the smallest capillaries to deliver oxygen. Acid actually strips away the negative charge of red blood cells and causes them to.


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You should not just want to put your products out on the Internet without being prepared. It may be a craft item.The following tips will show you just such directions on how to organize your business a success.
Flashy websites look neat, but they are also distracting. You have roughly five seconds to get the attention to your website. If your site doesn't look interesting by then, they will click out of your site.
Make sure you leave yourself open to receiving feedback at each stage. This is important to ensure you are getting an accurate portrayal of how your site. Get feedback from peers, relatives and even your competition. Use this advice to help you decide what to change in your website.
Regular blogging can really infuse your affiliate marketing campaign.A high-quality blog is one more way to communicate with your customer base. In addition, a blog adds content to your website, which expands your visibility to search engines, expanding the reach of your website and increasing your search engine rating.
You have everything you need to be successful in online marketing business right now. You do not need fancy software programs or any other get rich quick medium; all you need is yourself. Just work diligently and choose your marketing yourself.
Ensure your pages are informative and contain the details that your customers are going to need and want. Add interesting, articles and other content that will let prospective customers know that you are a business that knows your industry.
Give your customers a lot of choices to people when they check-out. You could also send an email with a choice of three different half-price items.
Many customers jump at the coupons with gratitude and as an added incentive to go back to a coupon to buy something they needed or wanted anyway.
The internet has turned business an anonymous affair. This tactic is truly effective for smaller businesses that rely on the personal relationships in selling.
Try to work phrases such as "limited edition" or "collectors edition" in your marketing copy.
You need to provide a portal for customers on your visitors to interact with one another. Your website can turn into a social network than a convenient place to find your products.A sense of community can be a powerful motivator to turn a one-time visitor into a habitual one; fostering a community for your customers while allowing users to make important business contacts.
It is important that you learn proper usage of HTML tags. HTML tags serve to indicate how important content is within your site. Search engine spiders will evaluate your page according to tags.
Use a lot of headlines throughout your site and in ezines.These headlines should be catchy and showcase products sold at your site. You could even want to abandon the headline altogether and add a graphic of your product. Graphics can often times seem more professional than a headline.
People respect those in business. Let others know that you're your company. You can refer to yourself as the business's President or CEO of your firm.
It may sound tempting to maintain a profile on every possible social networking site, but consider the time that would need to be invested to keep them up-to-date and functioning. Profiles that have not been updated recently are often seen as spam.
This can be a rare exception to the rule of not mixing your personal life with business. This is mainly because the pressure is lower and it can be seen as being a hobby that just happens to make you money. Get your wife and make it a team effort!
It is always best to handle all customer complaints on your own. You might want to use outsourcing for your business needs, but you should do this yourself.If you get an email from an unsatisfied customer, be sure you personally address their concern, and offer them a resolution to the problem.
You need to have good leads to get sales.Real-time leads are great because they give you access to a probable customer immediately that has been looking for information on your merchandise. You get access to that customer the sale.
Are you looking for an effective way to market yourself online?Give visitors reasons why they should provide you with their email addresses so that you can grow your opt-in list. People will be more likely to give you their own personal email if it could directly benefit them!
Have some promotions or events and see people flock to your website. You may offer a special one dollar e-book for a limited time. They may even make another purchase while they are there picking up their cart.
Try and see your site from your customers' prospective. Is it an enjoyable to read? Can orders be placed quickly and clearly? It's hard to swallow when you've done a ton of SEO only to lose the sale due to a shoddy website.
A lot of people won't believe the information you put in your advertisments are truthful.This is a result of many companies not being forthright about their products and services in the past. This makes it very important to support every claim you make on your site must be backed up with concrete proof. You can use reviews, testimonials, before-and-after photos and test reports, for instance. You should not make a claim that you cannot prove. You must take your customer's word as truthful and that they want to deal with someone they can trust. Do not take advantage of a customer.
The tips in this article can help you in your venture. Use what you learned here. With the information you have gathered you can create a marketing project that will be a success.


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In the beginning God created the heavens and the earth. Now the earth was formless and empty, darkness was over the surface of the deep, and the Spirit of God was hovering over the waters. And God said.… And it was so. God saw all that he had made, and it was very good. (Genesis 1:1–3, 30–31)
When God created the world, he was pleased with what he made. It was good. He created something out of nothing, which is hard for us to understand. God needs nothing and is truly self-sufficient. Yet he made the earth and everything in it, demonstrating his power and creativity.
He was particularly excited about the first people he made, Adam and Eve. "God said, 'Let us make mankind in our image, in our likeness, so that they may rule over the fish in the sea and the birds in the sky, over the livestock and all the wild animals, and over all the creatures that move along the ground.' So God created mankind in his own image, in the image of God he created them; male and female he created them. God blessed them." (Genesis 1:26–28).
God created Adam and Eve differently than all the other creatures. He created them in his own image. What do you think it means to be created in God's image?
Imagine what it was like to be Adam and Eve! No insecurities, achy muscles, or tired brains to slow them down. And God gave them the coolest jobs: naming the animals, exploring the garden, and enjoying his creation with him.
Obeying God was good for Adam and Eve. They were perfect and fulfilled. They weren't lonely or insecure. Every need was met. They lived with purpose in the best relationship with God and with each other. God clearly told them the consequence of disobedience: "You must not eat from the tree of the knowledge of good and evil, for when you eat from it you will certainly die" (Genesis 2:17). Choosing God is choosing life!
Taylor, S. (2017). Brand New: A 40-Day Guide to Life in Christ (pp. 16–17). Bellingham, WA: Lexham Press. Pic from Wakefield Bible Church... Pastor Mark.
The Bible is the word of God.Read Now
How can a young man keep his way pure? By guarding it according to your word. With my whole heart I seek you; let me not wander from your commandments! I have stored up your word in my heart, that I might not sin against you. Blessed are you, O Lord; teach me your statutes! With my lips I declare all the rules of your mouth. In the way of your testimonies I delight as much as in all riches. I will meditate on your precepts and fix my eyes on your ways. I will delight in your statutes; I will not forget your word. (Ps 119:9–16).
The Bible is the word of God. We can trust it! It was true when it was written, it is true today, and it will be true forever. The Bible is the standard for Christian faith and action. When we aren't sure if a belief or action is true, we should look at what God says in Scripture. God never contradicts himself.
"The word of God is alive and active. Sharper than any double-edged sword, it penetrates even to dividing soul and spirit, joints and marrow; it judges the thoughts and attitudes of the heart" (Hebrews 4:12).
Christians need to know the Bible, to study and memorize it. Psalm 119 calls the Bible a lamp for our feet and a light for our path. In showing us who to follow, it guides who we are and what we do. It builds up. It corrects us. It trains us in the way we should go. God's word is powerful. It's not empty, but instead it accomplishes what God desires.
The Bible teaches the history of God's people and the history of the King and Savior, Jesus Christ. This history is for all believers, even for us today. The Bible shows us who God is and what he has done, still does, and will do. It also shows us who we are and how we should live. Because Christ has already won the victory over sin, death, and the devil, we know that this victory will be ours!
All Scripture is God-breathed and is useful for teaching, rebuking, correcting and training in righteousness, so that the servant of God may be thoroughly equipped for every good work. (2 Timothy 3:16–17)
Is God's Word a light unto your path? What verse or verses have had the most impact on your life? What verse do you struggle most with putting into practice?
Taylor, S. (2017). Brand New: A 40-Day Guide to Life in Christ (pp. 12–13). Bellingham, WA: Lexham Press.
Recently, we began an exciting new journey through Scripture with the students of Marshall Baptist Youth about what it means to be a follower of Christ… what it mean to be a DISCIPLE.
We started by looking at the call of the first disciples to simply follow Jesus by faith on a lifelong, relational journey. Now, these teachings seem quite elementary for those who have attended church most of their lives; however, we read how Jesus spoke to His followers and gave them quite a challenge. Jesus told His Disciples (us) to "take up your cross daily and follow me" and unpacked the concept that discipleship isn't an option—discipleship is for every believer, not just the "super religious." As Christians, our lives should be marked by a total surrender to God's plan for our lives, not just our own personal desires for which we aspire and exhaust much energy.
Dr. Luke pens the words of Jesus, "If anyone would come after me, let him deny himself and take up his cross daily and follow me. For whoever would save his life will lose it, but whoever loses his life for my sake will save it. For what does it profit a man if he gains the whole world and loses or forfeits himself? For whoever is ashamed of me and of my words, of him will the Son of Man be ashamed when he comes in his glory and the glory of the Father and of the holy angels. But I tell you truly, there are some standing here who will not taste death until they see the kingdom of God." (Luke 9:23–27)
Matthew puts it this way, "And whoever does not take his cross and follow me is not worthy of me. Whoever finds his life will lose it, and whoever loses his life for my sake will find it." (Matthew 10:38–39)
We were and should all be challenged by the passages that remind us that we live in an upside-down Kingdom and that we must lose our lives to find them. Throughout November, as you process those things for which you are thankful, think also about what God has called you to—think also about what it means to be a true DISCIPLE by asking some tough questions:
Many blessings and much love as you chase after and embrace Jesus.
From MBC Newsletter; Inspired by The Life; YM360, and Andy Blanks...
WHAT DOES FREEDOM REALLY MEAN?Read Now
So you are no longer a slave, but a son, and if a son, then an heir through God. (Gal 4:7)
"Have you ever said, "It's my life. I'm free to do whatever makes me happy"? After a while, whatever you choose to pursue--popularity, alcohol, relationships, living selfishly, or trying hard to be perfect--becomes something that controls you instead of you controlling it. Soon the choice doesn't feel like a choice at all. Instead of being free, you're a slave.
Before we commit our lives to Jesus we are slaves to sin. Even if we try to be good, we still aren't free. Freedom is an illusion. We are tangled up in our sin, and it is impossible to set ourselves free.
When we commit our lives to Jesus, we are freed from our slavery. Only God brings real freedom. He frees us from everything we've been controlled by. Only God—who is absolutely perfect and all-powerful—can make us his children and save us.
Jesus forgives us. Jesus heals us. Jesus makes us whole. Don't be discouraged if you don't see instant change. The more you know God, the more you will become the person God created you to be. He knows what your purpose is, what is best for you, what you are good at, and how your experiences will be used in the future. He will help you get past what holds you back. He will make you whole." (Taylor, S)
So Jesus said to the Jews who had believed him, "If you abide in my word, you are truly my disciples, and you will know the truth, and the truth will set you free." They answered him, "We are offspring of Abraham and have never been enslaved to anyone. How is it that you say, 'You will become free'?" Jesus answered them, "Truly, truly, I say to you, everyone who practices sin is a slave to sin. 35 The slave does not remain in the house forever; the son remains forever. So if the Son sets you free, you will be free indeed. (Jn 8:31–36).
What are some things you have been a "slave" to? Describe what you think it means to be a "slave to sin." What will the truth do? How does it feel to know that you are God's child whom he has set free?
Taylor, S. (2017). Brand New: A 40-Day Guide to Life in Christ (pp. 10–11). Bellingham, WA: Lexham Press.
Let the Adventure BeginRead Now
And I will give you a new heart, and a new spirit I will put within you. And I will remove the heart of stone from your flesh and give you a heart of flesh. And I will put my Spirit within you, and cause you to walk in my statutes and be careful to obey my rules. (Eze 36:26–27).
...If you confess with your mouth that Jesus is Lord and believe in your heart that God raised him from the dead, you will be saved. For with the heart one believes and is justified, and with the mouth one confesses and is saved. (Ro 10:9–10).
If you believe Jesus died and rose again to forgive you and to give you true life, if you have asked him to forgive you, if you have asked him to be the Lord and Leader of your life, then celebrate! You have begun an incredible journey with the Lord of the universe... the Master Designer of all that exists. No longer do you have to worry about whether you're good enough for God or anyone else, because in Christ you are God's own child! You matter... You are important... You are loved! Nothing can separate you from the love of God in Christ Jesus. When you feel alone or when you experience guilt and shame, you can turn to God instead of running away from him. You are forgiven!
A relationship with God is bigger and better than any other relationship or anything you can buy or possess. It's permanent and it will change you more than anything else in your life. It's a lifelong journey of adventure.
For God so loved the world, that he gave his only Son, that whoever believes in him should not perish but have eternal life. For God did not send his Son into the world to condemn the world, but in order that the world might be saved through him. Whoever believes in him is not condemned, but whoever does not believe is condemned already, because he has not believed in the name of the only Son of God. And this is the judgment: the light has come into the world, and people loved the darkness rather than the light because their works were evil. For everyone who does wicked things hates the light and does not come to the light, lest his works should be exposed. But whoever does what is true comes to the light, so that it may be clearly seen that his works have been carried out in God." (Jn 3:16–21).
What are you excited about in your adventurous journey with God? What scares you about your journey with God? Why did Jesus come to earth? How do Jesus' words in this passage comfort you?
Taylor, S. (2017). Brand New: A 40-Day Guide to Life in Christ (p. 7). Bellingham, WA: Lexham Press.
You are the salt of the earth, but if salt has lost its taste, how shall its saltiness be restored? It is no longer good for anything except to be thrown out and trampled under people's feet. 14 "You are the light of the world. A city set on a hill cannot be hidden. 15 Nor do people light a lamp and put it under a basket, but on a stand, and it gives light to all in the house. 16 In the same way, let your light shine before others, so that they may see your good works and give glory to your Father who is in heaven. (Mt 5:13–16)
Tasteless salt and hidden light are good for nothing! Salt arrests decay in our world, and light banishes darkness. Salt is hidden, but light is visible. Both are needed in the world, and both must give of themselves in love and service.
"It is not easy to be a dedicated Christian. Our society is not a friend to God nor to God's people. Whether we like it or not, there is conflict between us and the world. Why? Because we are different from the world and we have different attitudes." (Wiersbe, W. W. (1996). The Bible exposition commentary (Vol. 1, pp. 21–22). Wheaton, IL: Victor Books.)
As we read the Beatitudes from the Sermon on the Mount, we find that they represent an outlook radically different from that of the world. The world praises pride, not humility. The world endorses sin, especially if you "get away with it." The world is at war with God, while God is seeking to reconcile His enemies and make them His children. We must expect to be persecuted if we are living as God wants us to live. But we must be sure that our suffering is not due to our own foolishness or disobedience. We must seek to be different.
From this passage, we need to see that Jesus' Words were echoing the words and callings of those from old--words and callings throughout the Old and New Testament--words, attitudes, and actions for us today. God has called us to follow Him in a special relationship because of Jesus and His love. Just like God called Abraham into a special relationship with Him, we need to follow God wherever He calls us. God reminded Israel throughout scripture of the relationship He had with them because of Abraham and His love for them.
We must let our light shine to not only reflect the promises of God, but to help the world see how to have an unconditional love relationship with God. Are you hiding your light under a bushel? Are you helping to add flavor to the lives of those in your circle so that they may taste and see that the Lord is good? In the days ahead, let us be a reflection of the image Jesus and His love, and light the path for others to see.
"And now, Israel, what does the Lord your God require of you? He requires only that you fear the Lord your God, and live in a way that pleases him, and love him and serve him with all your heart and soul. 13 And you must always obey the Lord's commands and decrees that I am giving you today for your own good. (Deut. 10:12-13)
My YouVersion reading today sparked my attention to share with you the simplicity of our call as believers. Often we ask, "What does God expect from me?" Here Moses gives a summary that is simple in form and easy to remember. He stressed that the law was not merely an outward ritual of sacrifice and festivals; but a heart attitude and a lifestyle of respect, love, and service for God.
Here are the essentials: (1) Fear God; (2) Live in a way that pleases him; (3) Love him; (4) Serve him with all your heart and soul; and (5) Obey his commands.
Too often we complicate faith with man-made rules, regulations, and requirements. We begin to attach the world's definition of "successful faith" to God's plan. Are you frustrated and burned out from trying hard to please God? Do you feel guilty because you cannot seem to keep up with the "religious" requirements that others deem necessary for you to be in right standing with God?
In Deuteronomy 11, God directed this call to the essentials most forcefully at the older Israelites who had witnessed first-hand His mighty acts along the way from Egypt to Canaan. Even the Children were held accountable. Failure to love, obey, and serve God would bring God's curse on both the people and their land. (Deut. 11:16-17)
Are you concentrating on His real requirements? Real peace is found "only" by the way of... Respect, Follow, Love, Serve, and Obey.
Pastor Shan Smith
Jesus follower, Husband, Father, Student Ministries Pastor at Marshall Baptist Church
February 2018


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Cloud Oakes
Painting Statement
My body tells a story that is similar to yours.
We all share in the tenderness of the human experience; our body language communicates even as we attempt to hide behind our public demeanor. This is the unapologetic human language that I work to capture in my paintings.
My body language, depicted in many of my works, creates a platform for observation into the intimate world of human emotion. My figures ask you to slip into their contortions and find within the patterns of human habit an emotive resonance. In this shared moment we can find a simple connection together.
The layered material, wax and oil, are painted onto raw wooden panels that I construct in my timber frame barn. I use the wood's grain to map the figure to create an effect of human skin and background patterns. The combination of the delicate wood grain molded into skin and the layered wax and oil express a contemporary voice that depict a life defined by strength and delicacy while the simplicity of the raw forms affirms the vulnerable act of being human.
We all have our languages and my most imperfectly perfect voice is to speak unintentionally through my body and thus intentionally through my art. I share with you a moment's pause in our human experience.
- Cloud Oakes
View Artwork by Cloud Oakes in Person
Come see these pieces first hand. We are just a short walk from the ferry and an excellent destination for your visit to San Juan Island.
- Hours Change Seasonally
- Call 360.378.3060
- Get Directions
- Contact Us
Purchase a Piece
Contact the Gallery to inquire about purchasing one of our fine art pieces.Contact the Gallery


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IT staff development and retention
- July 18, 2014
18 Jul'14
Culture shock: Apple, IBM, Microsoft disrupt themselves
IBM and Apple's pact to usher in analytics-enabled mobile apps to enterprises could be the start of a powerful friendship -- and spell doom for rivals. Plus, Google Q2 earnings and Oracle tackles Hadoop, all in this week's Searchlight.
- July 11, 2014
11 Jul'14
Win the tech talent race, go back to high school
CIOs chasing top tech talent might want to look past age on a resume. Silicon Valley firms are turning to high schools to edge out the competition; plus millenials could automate their own demise and high-tech veggies in Searchlight.
- June 13, 2014
13 Jun'14
Fulltime IT hiring is in; CIOs who can't manage change are on the way out
Job growth for IT professionals is going strong this year. According to an analysis by Foote Partners of the Bureau of Labor Statistics U.S. employment report, 15,600 more IT jobs were added to ...
- June 06, 2014
06 Jun'14
Information technology skills gap raise concerns for some
In this #CIOChat recap, participants discuss why information technology skills gaps are a concern and how to close those holes.
- June 06, 2014
06 Jun'14
What does it take to be a CIO: Passion and coding skills
What does it take to be a CIO? In this Searchlight, MIT CIO Symposium speakers share their journeys, while WWDC 2014 says coding skills are a must.
- May 30, 2014
30 May'14
Apple buys Beats and teaches CIOs how to get ahead
It's official: Apple buys Beats from Dr. Dre. Also in Searchlight, Google diversity report reveals the uncomfortable truth and the IoT gets a high valuation.
- May 20, 2014
20 May'14
Future of computing magnifies ITSM needs and the IT skills gap
Discuss how the future of technology is changing ITSM priorities and how to close the IT skills gap in this month's #CIOChat May 28 at 3 p.m. EDT.
- May 14, 2014
14 May'14
A GE CIO uses IT to boost productivity for employees, customers
Who says you can't serve two masters? GE Capital Americas, CIO Sigal Zarmi makes it IT's business to serve colleagues and win over customers.
- April 08, 2014
08 Apr'14
Seven not-so-obvious roles your analytics pro will have to play
What skills do CIOs and IT leaders either need to develop or bring in-house to take on big data and advanced analytics? According to Carol Rozwell, that question isn't necessarily the best place to ...
- April 08, 2014
08 Apr'14
Seven not-so-obvious roles your analytics pro will have to play
What skills do CIOs need to develop or bring in-house to take on big data and advanced analytics? Here are some not-so-obvious candidates.
- March 14, 2014
14 Mar'14
Careers in IT, rogue technology and a contextual computing love affair
As the workweek winds down, catch up on all of the news, tips, guides and videos you might have missed this week on SearchCIO and SearchCompliance. Is your CIO career in tip-top shape, or do you ...
- February 03, 2014
03 Feb'14
Inside the tech talent wars: Dropbox CEO talks how to recruit top talent
How to recruit top talent, what engineers want, and Dropbox for Business: The Data Mill reports.
- January 06, 2014
06 Jan'14
IT career survey 2013: Employee satisfaction, executive compensation
TechTarget's Annual IT Salary and Careers Survey uncovers the latest trends in IT executive compensation, employee satisfaction and the evolution of IT careers.
- December 20, 2013
20 Dec'13
The sum also rises: IT execs see compensation increase, expect same in 2014
A majority of IT execs saw a compensation increase in 2013 and look forward to another in 2014, according to our IT Salary and Careers Survey.
- December 20, 2013
20 Dec'13
How to resolve IT issues in 2014: #CIOChat IT resolutions abound
Have you made your IT resolutions list and checked it twice? Our #CIOChat participants weighed in how to resolve IT dilemmas in the New Year.


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Share Your Story • Pauline Acalin • January 30, 2015
The dipper looked bold on the horizon at the OC Astronomers star party, Anza, CA. 1-17-15, 9:48pm PST
Canon 50D, ISO 1600, 50mm, 6sec at f/1.4
Become a member of The Planetary Society and together we will create the future of space exploration.
LightSail 2 launched aboard the SpaceX Falcon Heavy. Be part of this epic point in space exploration history!


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When you want to start a business, try to make an innovation. You can make a new product or you can develop an existing product but become famous for the characteristics of your business. Start thinking about this from now on, because the longer you wait, there will be more and more business people who have innovated and developed the products. Make innovative business ideas, but also make that you already can. Meanwhile, if you need an expert or an organization which can help your business grow, just click here for info.
To start a business you must be diligent in conducting surveys. Find time to survey several business places that are related to the business you want to start. Also, do a survey in a place that can be the location to start your business.
Take the course
When you are free, try to find out what talents you have. Follow a number of SME courses that can help you find out what talents you have and how to develop them.
If you take a course, the things you can get are very much compared to when you study alone through the internet, but at the course, you can immediately practice the things you want to learn, get acquainted with experienced people, and meet new friends who are also interested in starting a business.
Cooperate With Business Partners
When you have an idea of what business you will build, the next thing to do is to invite friends who have potential and also the desire to start a business, so you can have many ways to start and develop it.
You can also search for some acquaintances who are professionals to get advice and opinions from people who have had long experience in the business world. Start mingling with many business people around you.
Test and Develop Products
When you want to start a business and try to innovate, at that time the thing you have to do is always test your innovation and keep trying to develop your product.
Those are some tips that you can apply to start your business early. So you won't have any more trouble when you start pioneering and grow your business.


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Jun 17, MSI: Sign In Become an Icrontian. The device's audio properties says "Use this device enable ". For the people using non MSI boards – the problem won't show up. The sound just doesn't work right.
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As for sound cards, I bought a standard Audigy Try also to run windows update or microsoft update.
As soon as you start loading the CPU the sound fails. I have the Socket Neo Platinum and love it.
But, if zound got an idea, I'm listening. Please, if anyone else is having this problem, send me an email. Sadly, i am reporting the exact same issue. Posted on Jun 29, Is that a chipset on that board? And also have tried latest direct X and updated Realtek drivers.
MSI PE Neo2-PFS – Platinum Edition – motherboard – ATX – Socket – iPE Overview – CNET
I simply love it — excellent sound quality for music and it has a optical out. Wouldn't be the first time i'm afraid. Powered with ill-gotten helium.
Me too, I have the same problem and I haven't been able to fix it for over five months now I have an MSI Neo2-P with all the drivers from the cd, and i havn't found anything else on the board reguarding sound issues. I have to turn off the computer for a msii seconds before turning it back on again so the sound works again. Jun edited Nov in Hardware.
Go into the sound configuration for the game, and switch it to something that doesn't say "Hardware". The audio chip are working. I have freestanding Series 8 dishwasher.
One particular game i play morrowind has an option to set sound for hardware or software mode.
MSI Ms-6728 865pe Neo2-p Platinum Edition Motherboard Socket 478
Oct 05, MSI: Any suggestions in that price range or should i save up. Again my board model is, MSI pe neo2-p platinum edition. Who makes the soundchip on the board? I have called MSI technical support and I have even changed my motherboard for a new one, the problem is still there Will let you know if I get anywhere.
I gave up on the onboard and bought an Audigy 865pee ZS May not be the answer you want to just go out and buy a hardware card but it sounds MUCH better and performance in games sounv increased now that my CPU doesnt have to process sound.
Want Answer 0 Clicking this will make more experts see the question and we will remind you when it gets answered. Ask a Question Usually answered in minutes!
SOLVED: NO Sound – PE Neo2-PFS Platinum Edition – Fixya
Sign In or Register to comment. Jose Velazquez Level 2 Expert Answers. Please msu your manual to a product: It's not even yet. So now i can't get into the program.


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PE polyethylene, which is transparent thermoplastic.
PE commonly used in three categories, namely: LDPE HDPE LLDPE Three kinds of polyethylene monomer is the same, but in the synthesis of these polyethylene, the process conditions used are not the same, therefore, only the generation of three different polyethylene varieties, three kinds of materials have a greater difference in performance. PE film is a good toughness of the material, not easy to use ordinary plastic shredder crushing. Because the PE film is soft and tough, it is not easy to chop, not to mention the high speed of the tool temperature, will make LDPE melt adhesion to the blade. PE granulation, can be directly into a strip into the extruder feeding port, by the shear force of the screw to drag the PE film into the barrel heating melt extrusion granulation. PE recycled primary materials, still can blow film, used in non-food and pharmaceutical packaging, but also widely used in the production of Oxford leather and waterproof cloth, the future is bright.


text: Lily Kershaw: Burning The Midnight Oil Amy Ebeling February 26, 2014 Goings-On Los Angeles-based singer Lily Kershaw will be making her way to the East Coast as part of a mini-tour alongside Mason Jennings. Kershaw's music began gaining attention in 2012, when her first single, "As It Seems," sold over 50,000 copies, despite her being an independent, unsigned artist. Since then, only good things have come, as she released her debut record, Midnight In The Garden, last September on Nettwerk Records. As part of her tour, Kershaw will be playing The Saint in Asbury Park on Feb. 28. Leave a Reply Cancel Reply Your email address will not be published.CommentName* Email* Website Save my name, email, and website in this browser for the next time I comment.


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