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Alexandra just finished her fer year of soccer. Her team, the Gators, had an end of the season BBQ to celebrate. They were all so excited to receive their medals:
Tuesday, May 26, 2009
End of the Soccer Season
Posted by Lisa Christine at 8:56 AM
Wednesday, May 20, 2009
American Idol
Tonight was the finale of American Idol 2009. I let Alexandra stay up 2 hours past her bedtime to watch it with me.
She totally had me cracking up a few times:
When Kara DioGuardi stripped down to her bikini she said:
"I did not need to see that"
When Rod Stewart came out to sing she asked:
"He's really old. Is he last years winner?"
Posted by Lisa Christine at 10:15 PM
Wednesday, May 6, 2009
Wish upon a star....
Lorelai: "Mom, what happens if a child wishes on a star and another child wishes on the same star?"
Mom: "Both their wishes come true."
Posted by Lisa Christine at 8:52 PM
Subscribe to: Posts (Atom)


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(WOOD) - As year-old Jamarion Lawhorn sat in the courtroom, charged with a brutal murder on a playground, his mom and stepdad took the witness stand. Anita Lawhorn also acknowledged spanking him with a belt since he was young. Jamarion was 12 when he fatally stabbed 9-year-old.
The mother of a child who just became one of Michigan's youngest Her son, Jamarion Lawhorn, who was 12 at the time of the stabbing, was found .. with 26 -year-old rumored beau Blake Schreck during night out in Miami.
Every parent's nightmare can happen in an instant. The story of year-old Jamarion Lawhorn, who was also on that playground on that day, Jamarion jurors: Shakes and sleepless nights · Jamarion Lawhorn abuse seq.
Jamarion Lawhorn, a deeply troubled year-old from Grand she has since taken his troubled mother, Anita Lawhorn, under her wing.
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text: Kerry Blaisdell is the award-winning author of The Dead Series, including DEBRIEFING THE DEAD—2019 RONE Award winner for Best Long Paranormal, HOLT Medallion Literary Contest double winner for Best Paranormal & Best First Book, Romance Writers of America RITA® Award finalist, and Royal Palm Literary Award finalist—and its sequel, WAKING THE DEAD, which InD'tale Magazine recommends for "fans of television shows like 'Constantine' or 'Supernatural.'" She also writes Romantic Suspense and Historical Mystery. She has a Bachelor of Arts from UC Berkeley in Comparative Literature (French/Medieval English), and a Master's in Teaching English and Advanced Mathematics from the University of Portland. Kerry lives in the gorgeous Pacific Northwest with her husband, two (mostly) adult "kids," assorted cats and dogs, and more hot pepper plants than anyone could reasonably consume.


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It all started out with a big dream for Sarah Geronimo, and through continuous hard work and dedication, she is now one of the biggest and brightest stars in Philippine showbiz!
2019 has been a very busy year for the Popstar Royalty as she has been juggling one project after another lately.
In fact, she has already started taping for her upcoming movie entitled "Unforgettable," directed by "Die Beautiful" director Jun Robles Lana.
Aside from dominating the big screen, Sarah also recently entered the world of make-up as she launched her very own make-up line called POP Studio!
Let's not forget that the Popstar Royalty has also been headlining sold-out concerts, not only in the Philippines, but also in different countries all over the globe.
Sarah has a way of making her audience feel an array of emotions through her versatile song and dance numbers, just like how she gave good vibes in this performance!
Sarah Geronimo: Good Vibes lang!
Taas kamay ang lahat ng nainspire sa kantang 'to ni Sarah G!!! 🙌
Posted by VivaEntertainment.ph on Tuesday, June 18, 2019
The Popstar Royalty's smile is truly contagious!
Related Articles:
Sarah Geronimo starts filming for new movie, 'Unforgettable'
Unveiling ng Pop Studio ni Sarah G, dinagsa ng fans!
Sarah Geronimo, wagi bilang Best Actress sa PMPC Star Awards!


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Go to www.luggage.com and at the left click on over 17" Ten narrow your search by price or what ever you want.
There are some 20" wide cases.
So with the 16" barrel and folding stock it comes to a detached 18" barrel and 18.5" folded stock frame at 4" wide (damn charging handle ;D
Any one carry theres in a breifcase or small tool box?
Im looking for a breifcase but may just go for a small toolbox with bottom compartment, cut some foam for the barrel and receiver and keep the quick detach ACOG and some mags on the top tool pullout.
Hope i explained that right
Pics if you got em >
Go to www.luggage.com and at the left click on over 17" Ten narrow your search by price or what ever you want.
There are some 20" wide cases.
get it SBR'd with a 12" barrel and you are down to 12" folded
Well i tryed Target,walmart,home depot, and lowes just to get an idea of what im looking for.
They had a perfect aluminum breifcase 1" too short :duh:
A nice 22" steel toolbox though. Have to think about it some more.
Check these.
Do you not like the Pelican or Storm cases that are available?
Certified SIG SAUER Armorer
If you are really set on a tool box - be sure to look at the Stanley Fat Max (available at Lowes for like $35). I use one as my gun cleaning kit / parts case and it is not only light and roomy (28" long), but has a rubber seal to protect against moisture. You can load it up heavy, and it is sturdy enough to take a beating.
Still - I like Pelican and Storm cases for weapon transport.
I carried my Pelican 1720 with my SBR LMT in it - into a hotel to check in, and the woman asked me if I played music. She thought it was a keyboard case I suppose. I just smiled and replied "I make some noise mostly" and left it at that. Kinda funny...
Certified SIG SAUER Armorer
Pelican 1720...
Certified SIG SAUER Armorer
I think i explained it wrong, im looking for the smallest least weapon looking carrying case there is ;D needs to be 18.5 inches long 4+ inches deep and about 9+" tall


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FALCON + Mission disk 1 & 2(still sealed) + official guidebook =70 was 80euro; (very nice conditions, mission disk 2 new, is still sealed)
KNIGHTS OF THE SKY = 20 was30 euro; (top...
Type: Posts; User: Olivier; Keyword(s):
FALCON + Mission disk 1 & 2(still sealed) + official guidebook =70 was 80euro; (very nice conditions, mission disk 2 new, is still sealed)
KNIGHTS OF THE SKY = 20 was30 euro; (top...
Game founded....
please close this thread
Money sent for all the games!
thank you for the deal!
Please close the thread
Game reserved, until December 1st, for a user outside amibay. He was the first to send an interest.
Next in line Jurrasicman.
Hello :-D,
I sell this rare and complete game for amiga: ESCAPE FROM COLDITZ. Very good condition and book never opened! but the floppy has an error (maybe has to be clean).:cool:
I m asking 70...
I 'm looking for the original cdtv game: Sherlock Holmes consulting detectvie...
if possible in good and complete condition.
Thank you
Interested ... all games!
interested in Pirates gold and Frontier
Box SOLD!... outside Amibay!:cool:
Commodore 64 SOLD outside amibay!
Hi mate... money received....and don t worry about the shipping ....I m a super expert...see my feedbacks! :cool:
Pm sent
Thank you :D
add new photos!
Hello :-D,
I sell a nice AMIGA 600 (only the computer). Very nice condition.The warranty seal has never been touched!The computer has been powered and used with some floppies... but not in 100% of...
Price drop..80 euro shipping imcuded![/QUOTE]
Last price drop...70 euro!
Price drop..80 euro shipping imcuded!
Hello :-D,
I sell a very nice C64. Very good condition (single-owner)! Only flaw a key is broken (easy to repair for those who are expert .. I am not).
I'm asking:70euro included shipping inside...
Hello :-D,
I sell a nice original box for AMIGA CD32. Very good condition (just a polystirol has a small crack),
I'm asking:130 euro.
Shipping costs excluded!
Payment by paypal.
PS. on sale...


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text: Hi Folks, we managed to unlock the new floor in the guild dungeon. I have included a sneak preview. Now, it seems that the Elite Guard - the single player thing - is bugged. Winning on easy "Start Challenge" is quite normal, you need to beat the guy. The higher difficulties, however, start with a kill stage. Hm. Given the fact that you are alone, it does not appear possible to win the higher difficulties. Can anybody confirm and/or check with the developpers? Thank you


text:
Judith Hoyt
Judith Hoyt has been making work with found metal, paper collage, as well as collage with encaustic wax for twenty years. She was born in 1958, in the Catskill Mountains of New York.
Travel loving Scot with an eclectic creative professional background. I love being busy in my studio, based in Fife, with commissions and artwork for my clients. I'm also getting to grips with running this redroadstudio blog, Pinterest, Instagram and Facebook page - deep breath!!


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text:
Feeling Academic in the Neoliberal University pp 261-280 | Cite as
On the Thresholds of Legitimacy: A Collaborative Exploration of Being and Becoming Academic
This chapter uses a collective biography methodology to explore threshold moments of academic legitimacy. They demonstrate the precarious processes and liminal spaces of being and becoming 'academic'. We examine how the well-documented practices that characterise the corporate/managerial/enterprise university frame the experiences of women aspiring to work in the sector and the affective and embodied ramifications of such practices as casualisation, contractualism, and competition between intellectual workers. Informed by work on academic subjectivities in contemporary universities (e.g. Bansel, Studies in Higher Education, 36(5), 543–556, 2011; Mewburn, Studies in Continuing Education, 33(3), 321–332, 2011; Petersen and Davies, Learning and Teaching, 3(2), 92–109, 2010; Petersen, Studies in Higher Education, 32(4), 475–487, 2007; Petersen, Educational Philosophy and Theory, 40(3), 394–406, 2008), and specifically on analyses of women's experiences (e.g. Clegg, Privilege, agency and affect: Understanding the production and effects of action. London: Palgrave Macmillan, 2013; David, Feminism, gender and universities: Politics, passion and pedagogies. Farnham, UK: Ashgate, 2014; Leathwood and Read, Gender and the changing face of higher education: A feminized future? Maidenhead, UK: Open University Press, 2009; Wilson et al., Gender and Education, 22(5), 535–545, 2010), we explore ambivalence, desire, disappointment, and at times joy in our experiences of securing PhDs and seeking work in universities. We argue that for early career and aspiring academics, becoming 'academic' is a precarious, contingent process where legitimacy is always provisional and reliant on conferral from those who are powerfully positioned in and beyond the institution of the academy.
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text:
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October 2019


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- Are mineable tokens possible? 2 answers
Just wondering if you could make a ethereum token that is mineable. I saw this link, but don't really know about it and i dont know anything about solidity. Can someone please help me? Thanks, Crypthusiast


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A Southern California native, Leonard reportedly wants to defect to the Lakers, but that team has a hard choice to make in terms of how many assets to offer the Spurs in a trade, as opposed to possibly being able to wait a year and sign him in free agency. So with the recent rumor surrounding Philadelphia being one of the teams that has already made an offer to San Antonio, here are three questions to consider surrounding the latest trade report involving Leonard.
For Irving, the Cleveland Cavaliers received Isaiah Thomas, Jae Crowder, Ante Zizic and Brooklyn's 2018 first-round draft pick. They have shown a willingness to take on salaries in return for assets in the past, in deals such as that for DeMarre Carroll.
Over 22 playoff games this past spring, James registered four triple-doubles, four double-doubles of points and assists and seven double-doubles of points and rebounds.
The point guard went on to say that his former teammate was "incredible" and checked off every mark statistically this year.
Cousins has been one of the best, and possibly at times, the league's best big man the past few seasons. They held a 3-2 lead on the Warriors in the Western Conference Finals but dropped the last two games of the series and were eliminated.
Instagram now rolling out video calls and other new features
Interestingly, to access these new camera effects , Instagram states you'll need to follow these accounts to gain access to them. To update your video chat notifications, tap the gear icon on profile and find the new video chat control in Push Notifications.
However, Cousins is coming off a torn Achilles tendon that he sustained in January, the same injury that effectively ended Kobe Bryant's career.
James' reluctance to speak with the Cavs heightens the excitement over the prospect of him bringing his talents to the Los Angeles Lakers., the odds-on favorites to acquire James this offseason.
The other concern with Cousins has been his attitude.
Both teams also believe a Leonard trade would "likely clinch" a commitment from LeBron James to join the Lakers as a free agent, per ESPN.
With a lot of cap space to work with, the front office for the Lakers will have plenty of options this summer.
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A Boat, a Whale & a Walrus: Menus and Stories
Renee Erickson
one of many country's such a lot acclaimed cooks, 2016 James Beard Award Winner Renee Erickson is a chef and the landlord of numerous Seattle eating places: The Whale Wins, Boat road Café, The Walrus and the chippie, and Bateau. This luscious cookbook is ideal for someone who loves the clean seasonal nutrients of the Pacific Northwest. Defined by means of the bounty of the Puget Sound quarter, in addition to by means of French food, this cookbook is stuffed with seasonal, own menus like Renee's Fourth of July Crab ceremonial dinner, Wild meals Dinner, and a fall pickling get together. domestic chefs will cherish Erickson's easy but stylish recipes akin to Roasted bird with Fried Capers and Preserved Lemons, Harissa-Rubbed Roasted Lamb, and Molasses Spice Cake. Renee Erickson's nutrition, informal sort, and appreciation of easy attractiveness is an concept to readers and eaters within the Pacific Northwest and past.
You'll Have additional i feel in leftovers. those recipes make the volume of nutrition I'd serve at my very own domestic, yet be aware of that i'm a restaurant cook dinner. i love to open the refrigerator and take into accout the former day's paintings, within the kind of a chew of a savory butter unfold on toast, or a wisp of dessert that i will be able to sneak right into a bowl subsequent to my morning espresso. I additionally consume greater than most folk, probably simply because I'm used to restaurant-size parts. So dig in, and anticipate to avoid wasting for later sometimes. purchase reliable.
To dry, leaving the dust within the backside of the bowl. For foraged mushrooms, like morels and chanterelles, I usually repeat this strategy a number of instances if they're additional soiled. Crushing Sea Salt even supposing i exploit a number of kinds of salt, I'm now not a tremendous fan of getting a complete counter packed with salt containers. I in most cases have simply sorts of sea salt: both Maldon, Jacobsen, or one other flaky sea salt, and a grey sea salt, comparable to sel de Guérande (see Resources). i take advantage of it as is, or, if i would like smaller pieces,.
by no means opened an oyster ahead of, commence with a delicate, fresh towel on your left hand. carry the cupped a part of the oyster within the palm of your hand on most sensible of the towel, with the hinge (pointed) finish towards your wrist. (You can positioned a heavy-duty glove at the hand protecting the oyster, if you're shucking loads of oysters or believe accident-prone). utilizing your correct hand, insert the purpose of the knife into the hinge of the oyster, urgent lightly at the hinge until eventually you're feeling it pop open. (Some humans say you press.
moment roast. whilst the 1st shoulder is easily browned, move it to a wide, high-sided roasting pan and repeat the searing method with the second one roast, then move the second one roast to the pan with the 1st. → Preheat the oven to 350 levels F. → rigorously pour the recent oil out of the pot and discard, then upload the garlic, celery, carrots, bay leaves, 2 cups of the wine, 2 cups of the inventory, and the onion. convey to a simmer, then cook dinner for five mins, till the onion starts off to melt.
Farm Luster, Corky, 5.1, 5.2 Mitchell, Jeffry, 9.1, 9.2 Monberg, Lissa James, 4.1, 4.2 Omegna, Carrie, 6.1, 6.2 eating place employees, 12.1, 12.2 Salvo, Jason, 8.1, 8.2 Steiner, Curtis, 2.1, 2.2 peppercorns, as flavoring for pickles, 10.1, 10.2 peppers clean Pepper Pipérade Roasted pink Pepper Flan Sautéed Padrón Peppers Pesto, Mint and Parsley Pesto, Walnut-Parsley Pesto with Walnuts, Nettle pickles herb and spice flavorings for, 10.1, 10.2 Pickled child Eggplant Pickled Beets.


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Hey Chester, don't chya think your shack is cramping your style?
Hey Chester, don't chya think your shack is cramping your style?
An older lady rests on a zinnia as the sun rises. Her grayish fur and tattered wings are a clue to her longevity and provoke the imagination of her many adventures. Bees don't fear death because the story is not about them.
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"Hey lady can you tell me, where a bee might find a bed?" She just grinned and shook her head, "There," was all she said. Another bumble settled in for the night, this time on a cosmo. I can't help but be tickled by these creatures! I love them to pieces.
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In our fountain-pond, we used to have floating flowers so bees and birds could enjoy the water without drowning. Unfortunately, they didn't hold up to the harshness of the winter or changing temperatures. So now I'm a lifeguard. Every night, I fish out one or two bees who've accidentally found themselves in the pond with […]
How lucky are we to know someone like Jim and his pack who are so hard to say goodbye to?
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I was getting a bit worried because last April, we had crickets singing love songs every evening. This year, it's been ominously quiet. But now they are turning up in the Osteospermums by the dozens and they are growing and getting greener every day. Welcome baby katydid! Looking forward to the music of your kind!


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Lawrence Coulson
Come With Me (2013)
- Framed Canvas On Board
- 42in x 16.75in
- Edition size 95
A signed limited edition canvas on board of 95 by acclaimed landscape artist, Lawrence Coulson entitled Come With Me
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Session (4 of 4)
Shane Willard
中国 - 简体和繁体 (25)
如何到部长驱邪(领导人) (1 of 8)
自由的基础 (2 of 8)
心的牢笼 (3 of 8)
法律有权进入 (4 of 8)
两个王国 (5 of 8)
创伤性经历 (6 of 8)
我们被邀请成为圣灵部长 (7 of 8)
耶稣的部 (8 of 8)
Mike Connell Sets (37)
Activating the Gifts of the...
Deliverance and Healing
Exercising Spiritual Authority
Basic Deliverance Training
First Principles
Slumber of Jezebel
Rest of Faith
Comfort in Times of Trouble
The Spirit of Mammon
Forces that Work in You
Healing from Abortion, Misc...
Freedom Evangelistic Messages
Who is Jesus
Taming the Tongue
Deliverance Training (Speci...
The Blood of Jesus
Five Seconds After You Die
Hearing the Voice of God
Fig Leaves and Other Coverings
Wilderness Wisdom
Purpose & Destiny (2011)
Breaking Free from Victim M...
Freedom Conference
Authority in the Family
Burnt Stones
The Prayer of Kings
Extravagant Love
Blame Game
Let the Kings Arise
Standing in the Storms of Life
The Making of a King
Priority of the Kingdom
Destiny Decisions
Shane Willard Sets (9)
Leadership Seminar (Shane W...
Ten Commandments (Shane Wil...
Finance Seminar (Shane Will...
Hosting Shane Willard (2013)
Hosting Shane Willard (2011)
Hosting Shane Willard (2010)
Hosting Shane Willard 2008 ...
Session (1 of 4) Hell
Session (2 of 4)
Session (3 of 4)
Session (4 of 4)
Hosting Shane Willard (2008)
Hosting Shane Willard (2007)
Mike Connell Sermons (29)
Pentecost - Fresh Filling o...
Resolving Offences
Arise and Stretch
Two Principles that Release...
Fathers Day 2012 - Valiant Men
Handling Life's Difficult E...
Discover your Assignment
Withered Hand
Samson - Man of Faith
Doing the Works of God
Five Loaves and Two Fish: K...
Vision to See
Foundations for Fruit Bearing
Zealous for Good Works
Pursuing Greatness and Eter...
Easter Service (2012)
Filling Your Lamp
Having a Full Lamp
Wise and Faithful Servant
War a Good Warfare
Break Through (2 of 2)
Breaking Free (1 of 2)
Training your heart to see
Lessons to Learn in a Prison
Witchcraft in Relationships
Relationship or Rights
Gods Mandate to Parents
The Orphan Spirit
Page 2 of 8
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So we've eaten stuff and we're even past all the normal, normal dating, like it's okay to even like have gas in the car or something okay? [Laughter] And so we're past all that and so I'm standing on her front porch and I've got melted pizza cheese coming off of my mouth. [Laughter] I've got oregano in my teeth and there's just this moment. There's this moment at the front door and everything just feels right. Everything just feels right and my heart starts pounding - boom boom, boom boom, boom boom. I think I can say it now. I can say it, I can say it, so I look at her and I say Cecilia, lakah. [Laughter] And so then there's this moment on the front porch and she can't keep her hands off of me [laughter] and there's all this stuff. She's trying to act calm on the inside, but I just said lakah to her so she goes inside and she calls all of her girlfriends and she's like he said lakah to me! He said lakah to me! Oh my God! He said lakah to me! [Laughter] This was lakah. Lakah meant I want to make you my own. [Oh, awe.] I want to make you my own, all mine. [Laughter] How can you resist this! [Laughter] My Lord! [Laughs]
So in the Book of Exodus 6:7 there's this group of slaves and God has gotten them out of Egypt and He's moving them to freedom. So this group of people who've known nothing but for 430 years they've been slaves. Four hundred and thirty years, that's a long time. I don't know how long New Zealand's been a nation but I doubt it's 430 years. That's twice as long as America's been in existence. Four hundred and thirty years is enough time to develop a whole culture around slavery and oppression and victim. He's talking to this group of people and here's what He says in Exodus 6:7; And I will take you as My own people. If you look that word up in Strong's it's lakah, lakah. So this group of Hebrew slaves who knew this whole process, the God of the universe looks down from heaven and He says lakah. Can you imagine how they would have felt; a group of people that would have felt less than - they had been told that they're less than human. They would have been killed. They would have been tortured. The would have been all of this because they were told they were less than human.
The God of the universe is actually - can you imagine? Everybody would have been saying did He just say lakah? Did He just say what I think He said? Like did He just - does He want to marry us? Like does He want to make us His bride? Like did He say He wanted to make us My own? That is lakah - and He starts the process in Exodus 3 by getting them out of slavery. Then He starts the process again in Exodus 6 by saying lakah - so we're dating and I've said lakah and she's called all of her friends. Now how long - once she hears lakah, what is the next word she's longing to hear? Segullah. She really wants me to say segullah, and how long does the euphoria of lakah last? Maybe a month, maybe two, but after two months her girlfriends will be calling her during the day: girl, has he said segullah yet? Has he said segullah yet? He needs to - where is he? Is he scared of commitment? [Laughter] He needs to step up to the plate. It is time. He has been sitting on lakah far too long. [Laughter]
So one night we go out on a date and we eat, I don't know, fish tacos or something. [Laughter] We're in the car on the way home and there's just a moment. There's a moment and I get her to her front porch and everything feels right, and she's got a piece of that fish taco hanging off of her lip. [Laughter] I look and I think oh yeah! [Laughter] You're the one for me! [Laughter] And just the right moment I take her by the hand and I say segullah. Well now she really can't keep her hands off of me! She's trying to act calm but inside her heart's fluttering. She runs in and she calls her girlfriends and she's like he said segullah to me! He said segullah to me! Oh my God! He said segullah to me! [Laughter] Segullah meant - it took lakah one step further and it meant treasured possession. The girls love this message. [Laughter] I've been asked to preach this specific message next year at a national conference for women. They're going to go crazy. [Laughter]
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Just a few quick thoughts here, but some aircrew (and I am particularly thinking here of the Flight Engineer, although it could apply to any of the other categories) did not volunteer for the RAF (more likely RAFVR) in the first instance as aircrew, but could have been any trade in theory before deciding to "have a crack at aircrew" at some subsequent date. This was known as "remustering" to a new trade, and once accepted for aircrew the eager aspirant would be posted to ITW for the mandatory period (early on this would be just four weeks, but later in the war extended to six weeks; when the "PNB" system took over in 1942/43 there would also be a aptitude testing, then an attachment to a type of flying training on Tiger Moths to sort out those most suited to pilot, or other aircrew. Air Gunners were always a little different in that the actual training of air gunners was relatively short (after ITW in the early days it was a short but intensive 4 weeks, then straight to the squadron, later of course they went via OTUs to the squadrons, still later through HCUs, etc). However many of the early A/Gs were primarily Wireless Operators (as WOAGs) who had to complete quite a long course at Wireless School before undertaking the gunnery part. The "ten hours" you have listed for EFTS is way off the beam, and I think this was meant to indicate the approximate number of flying hours at EFTS required to go solo only, as normally the EFTS course required from 8 to 12 weeks, depending on the stage of the war. This would amount to something like 45 - 60 hours total (solo and dual I think), with subsequent SFTS requiring at least twice that amount of flying. In fact I think that later in the war a pilot would have about 200 hours up at the end of SFTS (and award of flying badge). Thereafter there were several further stages as you have noted, so that pilots would probably be approaching 300 hours or so by the time they arrived at their first squadron. However you should consult real log books to get more accurate flying hour figures for the different periods of the war. Incidentally our American cousins usually considered that British Commonwealth Air Training Scheme graduates were still far too inexperienced to be turned loose and in command of a large bomber aircraft (or even a fighter aircraft for that matter) in a front line squadron, but nevertheless the RAF just had to ignore that and they still managed to come out on the winning side in the end (although not without some assistance from Stalin and Uncle Sam after 1941). Earlier in this rambling account I alluded to the case of the Flight Engineers; almost without exception, the RAF obtained these gentlemen by soliciting volunteers from among the more experienced ground staff in the Flight Mechanic and Fitter IIE trades (and perhaps a few others), and they were then sent on a special qualification course to be completed before being awarded their "winged E" badge. Late in WW2 many surplus multi-engined pilots were also invited to apply for F/Eng training, because it was either that, or a transfer to the Reserve, so quite a number of pilots (probably in the hundreds) qualified in this new (and probably unexpected) trade. Because of RAF dress regulations, however, most pilots so qualified, nevertheless retained their pilot's badge as the said regulations specifically did NOT allow more than one aircrew badge to be worn by any individual at the same time, so you can guess which one most chose to display.
David D


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WSB TV reports on the new DeKalb Entertainment Commission. Reporter Audrey Washington talked with the Commission's director, Shelbia Jackson, and highlighted DeKalb-based Third Rail Studios.
Atlanta Journal-Constitution (10/10/17): Movies, music and gaming recruited to DeKalb County
The AJC reports on the official launch of the new DeKalb Entertainment Commission. The Commission's Shelbia Jackson says: "The purpose of the commission is to help us build an ecosystem that supports the [entertainment] industry in DeKalb." Read more: http://tinyurl.com/yc7pcoxv.
CBS46 (10/9/17): New DeKalb Entertainment Commission Launches
CBS46 reports on the launch of the new DeKalb Entertainment Commission. Live from Blackhall Studios, one of several new studios in the county, Adam Murphy talked with DeKalb's Shelbia Jackson. Click the link or the video below for the full story: https://t.co/VtooYuYfM4.
New DeKalb Entertainment Commission Launches to Drive Economic Engine of County's Entertainment Industry
Oct. 11 — Launch Event Connects DeKalb Industry Influencers
Oct. 21 — Entertainment Expo: Panels on Film/TV, Music and Digital Gaming
Media Contacts:
Mitch Leff: email@example.com | 404.861.4769
Melissa Sanders: firstname.lastname@example.com | 404.909.6726
DECATUR, GA — The new DeKalb Entertainment Commission officially launched on Wednesday, October 11, 2017, with a gala, red-carpet event including hundreds of Georgia entertainment industry leaders and influencers. A division of Decide DeKalb, the Development Authority for DeKalb County, the Commission is charged with stimulating economic growth across the country in film, television, music and digital entertainment. Continue reading "New DeKalb Entertainment Commission Launches to Drive Economic Engine of County's Entertainment Industry"


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Is there a wrong way to Juice?
by Healthy Homestead Team
6 months ago
You saw a commercial on a juicer, and you go buy one. Next, you read about the benefits of juicing, and you just start throwing everything in the juicer. The worst part is you might think you are eating healthy. And yet, the benefits are not coming your way. So, what is the problem? Well, the reality is that there is a right, and a wrong way of juicing. Today, we want to share with you some juicing mistakes you might be doing without realizing it.
Using too many sweet fruits
Juicing is one of the best ways to get healthy nutrients in your body. That includes vitamins and minerals from fruits and vegetables. However, the common mistake among newcomers is adding too much fruit. Yes, we know that makes the juice sweeter, but you do not want all that sugar.
Tropical fruits like mango and pineapple are very high in sugar. And while that is natural sugar, it is still sugar that you do not want in large doses. If you are on a weight loss plan, we do not recommend juicing fruits.
Now, we are not saying you should ignore fruits altogether. Add some fruits to your vegetable juice for extra boost of flavor.
Your juice lacks the color green
The key to making healthy juices is adding green vegetables. There is no other way around it. You should make the bulk of the juice out of green veggies. There is a simple reason for that, as green juices are packed with nutrients.
Green vegetables produce chlorophyll, which will help oxygenate your body. Green juices also help you detox and cleanse your body, improve circulation, and provide a boost of energy.
Using same ingredients over and over again
This is one of the biggest mistakes you can make while juicing. We understand, you fall in love with a certain juice, and you prepare it every single day. When you consume the same juice over and over again, you ignore and avoid healthy nutrients from other veggies and fruits. For example, if you use kale every day, you might be missing out on spinach, another great leafy green.
Not drinking it right away
Juicing takes a little time and effort. And you want to reap the benefits instantly. Now, we understand that some of you might be inclined to prepare a large amount of juice, and have some stored in the fridge. But healthy juices are best when consumed right away.
And timing is everything. If you want to get the most out of your healthy juice, drink it in the morning on an empty stomach. Or at least 30 minutes before a meal. This way, your body can absorb all of the healthy nutrients of the juicer quicker.
Not cleaning your vegetables
We strongly recommend using organic products when it comes to juicing. Or, at least washing your products before juicing. Washing helps you avoid and clean any pesticides and chemicals found on the peel of the fruits and veggies. You definitely do not want to digest them.
If you are on a budget, you might be better with some frozen products for a cheaper price.
Do not rely on juice alone
Juice alone cannot provide all the nutrients your body needs. Vegetable or fruit juice is only an accompaniment to a healthy meal. Consume juices between meals for an energy boost. But do not fall into the trap of thinking juices can replace meals. They cannot. You still need fiber from whole vegetables, and juice does not provide that. Juicing makes it easy to absorb more servings of fruits and veggies per day, but you need whole food as well.
Gulping juice instantly
You took 10 minutes to prepare your juice, and now you are gulping it as fast as you can? Well, there goes wasted effort. Digestion starts in the mouth, not inside the stomach.Drink your juice slowly, do not gulp it in a matter of seconds. Enjoy the flavor with your tongue, and drink slowly. Think of the juice as a fine wine. You do not drink that expensive wine in a matter of seconds, do you?


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Excursions into the Wild
This chapter examines instances of what Scott Slovic calls "going away to think" and how going away also implies a return, creating a continuous oscillation between being grounded and groundlessness. These samples reveal how becoming an errant body, even perhaps only intermittently, can provide the foundation for a compendium of innovative thoughts and new ways to be in relation with the world. In many cases, this has meant breaking from the world and sidestepping its limitations in order to reach a new frontier. A diverse juxtaposition will bring together disparate "excursions into the wild" by Henry David Thoreau, Margaret Fuller, Jean Baudrillard, and Hamish Fulton in order to demonstrate how being in retreat can be a method of engagement—how getting lost can lead to discovery.


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Stahls' Announces June 2019 'Workshop Wednesday' Event
Stahls' 2019 "Workshop Wednesdays" educational series continues on June 19 with two new classes "Artwork 101 and 201." With artwork being the key to creating profitable products, you'll learn how to take your designs to the next level using Cadworxlive.com and Transfer Express Easy View.
Learn how to increase profit by offering eye-catching designs that reach different markets as well as the tools in cadworxlive.com and how to use them. Also included will be tips and tricks for creating mockups to present to the client for approval.
There also will be a complete review of Transfer Express Easy View design software that can be used for created customized screen printed transfers and Easy View layouts and clipart.
Artwork 101 runs from 10 a.m. to 1 p.m., and 102 starts at 2 p.m. and goes until 5 p.m. Sessions are available at the Arizona, California, Florida, Michigan, Ohio, Pennsylvania and Texas showrooms and training facilities. The cost is $19.95 per person for each class. Or take both classes for the bundled price of $39.95 with lunch included.
Check below for class dates, locations and contact information and go to http://bit.ly/stahls-workshops for more details. Reserve your place early; seating is limited.
Here's a list to find the Stahls' location nearest you:
Stahls' Arizona
6900 W. Morelos Place
Chandler, AZ 85226
(480) 763-1060
Stahls' California
160 Vander, Unit C
Corona, CA 92880
Stahls' Florida
949 Beville Road
Building D, unit 3-4
South Daytona, FL 32119
(800) 478-2457
Stahls' Michigan
6353 14 Mile Road
Sterling Heights, MI 48312
(586) 772-6161
Stahls' Pennsylvania
135 Wayland Smith Drive
Uniontown, PA 15401
Stahls' Texas
3680 W. Royal Lane, Suite 115
Irving, TX 75063
Stahls' Transfer Express
7650 Tyler Boulevard
Mentor, OH 44060


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Ash210501 needed a new postcard, flyer or print design and created a contest on 99designs.
A winner was selected from 36 designs submitted by 13 freelance designers.
Marine Repair Services - Container Maintenance Corp
Maintenance and repair of intermodal equipment
a one page invitation/flyer
Am suggesting certain photos grabbed from Google pertaining to Graceland, feel free to try other photos that you like. the MRS logo should be attached on the flyer and is below.


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Search results
Post Implementation Review of the Postal Services Act 2011
The Consumer Council is a non-departmental public body (NDPB) established through the General Consumer Council (Northern Ireland) Order 1984. Our principal statutory duty is to promote and safeguard the interests of consumers in Northern Ireland.
- Post
Response to Draft Programme for Government Framework
The Consumer Council is committed to developing a better Northern Ireland and therefore is encouraged and enthused about the outcomes based approach taken by the draft Programme for Government (dPfG) for 2016-21.
- Business
- Consumer Skills
- Cost of Living
- Energy
- Food
- Personal Finances
- Post
- Transport
- Water
- Other
- Other
Ofcom's review of the Regulation of Royal Mail
As the statutory representative for consumers of postal services in NI the Consumer Council is pleased to respond to Ofcom's consultation on the review of the Regulation of Royal Mail.
- Post
Shop Around quiz - August 2016
A fun quiz for young adults for young people to learn about their consumer rights when shopping on the high street and online. Have a go and test your consumer rights knowledge.
- Consumer Skills
- Other


text: I'm curious what types of pedals (not specifics by name, but just the sort of effects) people here feel are their absolute must-haves and why. I've been a guitar-wire-amp guy for about three years now, and I'm perfectly happy with that, but for fun I've decided to poke around at pedals again (I no longer have any interest in a new guitar or amp, after all). For me, I think the basics are: Chorus - Probably my favorite effect, and I have to admit that I'm not all that picky about it. Reverb - I don't have it in my amps. Of course, both amps also have no effects loop, so I'm kinda stuck unless I add it at the board, as it tends to sound funny in front of the amp. Overdrive/Clean Boost - Preferably in one box. Volume - The expressive power of a volume pedal is one of my favorite things about the electric guitar. I need one now. Effects that I don't personally use at all: Flanger/Phaser - Everybody wanted them when I was a kid. Now I rarely see them in use. Compressor - I feel like I *ought* to want this, given what a staple it is for so many players, but I've never enjoyed having one in the signal chain. Tremolo - Again, feels sort of like an "ought to" effect, but I've never had a use for it beyond goofing off Pitch shift/harmonizer/octaver - Just "too much" for me. Some players have used them to great effect, but I just get in trouble with sonic overload when I try. Rotary speaker - Ditto. I'm on the fence about: Wah - Great in theory, fun to play with, but I seldom use one. Really annoying to the audience when overused. Distortion - I am leaning toward getting one box for just over the top grind, but I know I'll use it pretty rarely. Delay - Lots of fun, but again, not sure about its utility to me. So what are your essential effects and why?


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Relic Online Play
A turn-based RPG with nice graphics. Talk with characters and loot chests. As a comment we let you know that Relic game is one of the best action games and... a lot of fun is waiting for you when you playing Relic online game, the game that many players have chosen it as their favorite, make your comparision and we hope you enjoy it. Remember that we offer you the best, funniest and the biggest collection of games in the world to play online. Relic has been played 568 times and recommended by 5 gamers. read more
- Rate this Game!
- Votes5
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Could type 1 or type 2 diabetes be to blame for the regular headaches that you experience? While there are many potential headache causes, diabetes has been known to cause headaches in some people.
Headaches related to diabetes generally occur due to changes in blood sugar levels. They can affect diabetics (and prediabetics) when blood sugar is too high or too low. The more blood glucose levels fluctuate, the more likely it is that one will experience headaches.
According to medical researchers, fluctuations in blood glucose are caused by changes in hormones such as epinephrine (adrenaline) and norepinephrine. These hormones are thought to cause blood vessel constriction, specifically constriction of blood vessels in the brain.


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Do you use herbs for your health and personal care?
Are you looking to deepen your knowledge (or learn for the first time!) how to prepare herbal remedies for yourself and your family?
Do you relish spending time in nature, basking in the calming and restorative atmosphere of forests, wildlands, and other natural areas?
Maybe you're drawn in by the magical, mystical, and often miraculous ability of plants to heal our bodies, minds, and souls...
Ancient systems of natural healing, such as botanical medicine, Ayurveda, and Chinese medicine, have shown us that plants have remarkable healing properties that can help transform your life's journey. They can heal your body, open your mind, and even reverse aging.
And those healing, transformative benefits are as close to you as your own garden.
There are an infinite number of ways you can bring plants into your life and use them safely and effectively to enhance your wellbeing. So it's no surprise that three out of four people in North America use herbal medicines on a regular basis — be it turmeric for arthritis, St. John's wort for depression, ginkgo for memory, or any of a myriad other herbs to manage and improve their health.
Even common weeds like dandelion, plantain, and horsetail can be effective remedies and have powerful healing effects...
Aside from taking plant medicines, we also gain physical and mental benefits from plants in many other ways, from walking in the woods or by the ocean... from tending our gardens... from improved air quality due to trees and plants thriving in the neighborhood... and the list goes on and on.
Surely you've experienced, and intuitively know it to be true, that plants can put you into a state of deep communion with the natural world. Simply being in their presence is healing and rejuvenating. Truly, plants are to people as water is to plants — simply indispensable.
In this special free event, Chanchal Cabrera, a medical herbalist, master gardener, and horticulture therapist with 35 years of clinical experience, will explain why herbs are critical for both personal and planetary health.
When we connect with the deep sentience, wisdom, and healing power within the plant "kin-dom," our eyes are opened to new realms of knowledge, and we come home to our bodies and our lives in a different way.
While plants are essentially collections of chemistries, they are also energetic entities, obeying the laws of nature and integrating themselves into an ecosystem that shapes, informs, and nurtures them, and which they in turn shape, inform, and nurture.
Herbs and other plant medicines offer us hope, beauty, and the opportunity to create an intimate relationship with the Earth — one based on mutual respect and care.
Plants are the vehicles that bring us the energy of the sun and the nutrients of the soil that we need for life. Understanding their therapeutic powers gives us a deeper cosmological view and a more dynamic relationship with the life force around us. Medicinal plants in particular can help us cultivate more prana or chi, and heal and harmonize our bodily systems.
This knowledge is vital to navigating the many stressors of life, from work to the challenges of aging. Proper use of medicinal plants can help make you more centered, healthy, and vibrant — rebuilding your immune system and detoxifying your organs and tissues.
Join us for an illuminating hour that promises to deepen your appreciation of the interconnectedness of all life on Earth and the multifaceted healing powers of nature.
Engaging and passionate, with an unparalleled knowledge in all things herbal medicine, Chanchal will truly touch every one of her students. From biochemistry to plant energetics, from forest bathing to growing your own medicine, Chanchal has truly expanded my knowledge of herbal medicine and also my life... She's certainly one of the best herbal medicine instructors in Canada, if not the world. Chanchal is the anchor that has made my herbal medicine knowledge and training what it is today.
— Shawn Peters, BA, RHN, naturopathic medical student, Boucher Institute of Naturopathic Medicine)
In the course of every difficult journey into the unknown, gifted teachers appear to help us on our way. Chanchal Cabrera was and continues to be one of my gifted teachers. Her philosophy of healing contributed to a profound shift in my understanding of health, sickness, herbalism, and the natural world that forms the foundation of my herbal practice... Her extensive clinical experience and research skill compels her students to grow in ways they did not expect and to achieve on levels they never thought possible. I will be forever grateful for her instruction, mentorship, and friendship over the many years we have known each other.
— Evelyn Coggins, MHSc, CHT, RH(AHG), clinical herbal therapist
[Chanchal] has abundant knowledge and application of clinical herbal medicine, being well-educated and experienced in applying that knowledge. She's devoted to education, and a great communicator of knowledge to students both directly in the classroom, at workshops and seminars, as well as with apprentices in a direct setting... Chanchal is reliable and consistent in living up to her agreements with integrity. I'm delighted and honored to recommend Chanchal for any application in her field.
— Dr. Uwaya Erdmann, ND, Peterborough, Ontario
[Chanchal] is able to integrate Western medicine and an academic approach to teach to the highest standards. Thanks to her, many students have deepened their knowledge of clinical herbal medicine to complement their education in holistic medicine, nutrition, pharmacy, botany, and other healing modalities. I've the advantage of living near her wonderful Innisfree Farm in Royston, British Columbia, and have learned much from her through an internship and ongoing volunteering... You'll benefit from her down-to-earth teaching style and delightful personality!
— Judy Goldschmidt, Courtenay, British Columbia
As an early student of herbal medicine, having a teacher who inspires you to view plants beyond just their chemistry and clinical indications is a gift, and I often pinch myself for getting to have been so lucky to learn from Chanchal when starting out in my medical training. Now as a practicing herbalist and Naturopathic Doctor, there is still no other herbalist I would rather learn from, and I continue to seek out her teachings and instruction whenever possible. Her clinical expertise and profound knowledge and respect for the many facets and philosophies inherent to practicing holistic herbal medicine is a rare and precious thing. Chanchal is consistently a true joy to learn from, as she is able to weave together concepts such as plant energetics alongside advanced biochemistry and the sensory beauty of the plant world with ease, with each lesson enriching your life and herbal skill set in myriad of ways.
—Dr. Marisa Marciano, ND, Registered Herbalist, Vancouver, British Columbia
Chanchal Cabrera, MSc, FNIMH, (RH)AHG, has been a member of the National Institute of Medical Herbalists (UK) since 1987 and obtained her MSc in herbal medicine at the University of Wales in 2003. Her clinical specialty is helping people manage cancer.
Chanchal held the faculty chair in Botanical Medicine at the Boucher Institute of Naturopathic Medicine in New Westminster from 2004 — 2017. She serves on the board of advisors of Dominion Herbal College in Burnaby, BC, on the editorial board of Medical Herbalism clinical newsletter, and she publishes widely in professional journals and lectures internationally on medical herbalism, nutrition, and health. Chanchal is the author of the book, Fibromyalgia: A Journey Toward Healing, published by Contemporary Books. She's a certified master gardener and a certified horticulture therapist.
Chanchal lives on Vancouver Island, British Columbia, where she and her husband manage Innisfree Farm and Botanic Garden, a seven acre sanctuary devoted to medicinal herbs. They grow over 200 medicine and food plants, provide therapy gardens and programs for people with disabilities, host events and retreats, and run internships in organic farming and herbal medicine. The gardens are open to the public weekends in the summer.


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Fine art of opinion: N.Y. Times opinion artwork
In 1970, when the New York Times launched its Op-Ed Page, it presaged the Internet blogosphere by 3 1/2 decades. Suddenly opinions and bylines weren't the sole province of professional writers. Citizens could sound off on issues or argue for political change, which they often did with style and persuasiveness.
Jerelle Kraus was for 13 years the Times art director who conceived, commissioned and often defended the artwork that illustrated Op-Ed pieces. In her book "All the Art That's Fit to Print (And Some That Wasn't): Inside the New York Times Op-Ed Page" (Columbia University Press, $34.95), Kraus recalls the hundreds of artists she championed and the ways in which Op-Ed images reflected the nation's political and cultural pulse.
Her tenure was the longest of any Op-Ed art director, from 1979 to 1989, and then 1993 to 1996. From the beginning, Kraus said this week while visiting San Francisco with her partner, painter Arthur Dworin, "I recognized that this is a very significant phenomenon. It was the first time that outsiders, non-staffers, were allowed into the public forum."
Equally groundbreaking were the illustrations chosen to accompany Op-Ed pieces. They're not cartoons, Kraus says, "which is a word people use when they think of drawings in a newspaper. They're more towards fine art." Surrealism, metaphors and double entendres were employed.
"Art is not employed on Op-Ed to 'illustrate,' " said the page's first editor, the late Harrison Salisbury, (but) to create an environment which extends and deepens the impact of the word."
There are 142 artists from 31 countries and five continents in "All the Art That's Fit to Print," including Garry Trudeau and Jules Feiffer, Art Spiegelman and Andy Warhol, Keith Haring, Larry Rivers and Roland Topor. Kraus offers 320 illustrations, 52 of which were canned by the Times after the objections of timorous or clueless editors.
We see for the first time a Ralph Steadman drawing depicting the Ayatollah Khomeini as a camel directing a gust of flatulence toward Egypt. We see three Warhol portraits of Ted Kennedy that were killed by editor Charlotte Curtis because "they say nothing."
"Most artists who work on a page like this want to have as much freedom as possible," Kraus says. And yet, she writes, each year produced "a salons' worth of rejected images." In 1996, Milton Glaser drew an alien for a Valentine's Day manuscript about intergalactic love. "The editor who censored it said that the alien's beak looked like a taboo human part."
The same year, Cathy Hull's illustration of a sweating thermometer - commissioned for a piece about severe shifts in climate - was canned when editorial page editor Howell Raines regarded it and said, "It's an ejaculation."
She likes to talk
Slender, dressed in a red-and-white form-fitting Jean Paul Gaultier dress, Kraus is friendly, ebullient and loquacious to an extreme. She likes to talk, and the answer to a simple question can easily take multiple detours and spins around the globe before returning to the point at hand.
A California native, Kraus was born in Napa to a "Mayflower WASP" mother who at 15 ran off with Otto Kraus, 38, a Viennese Jewish philosophy professor. They never married. Kraus grew up in Pasadena and the Bay Area, and went to Swarthmore, Pomona College and UC Berkeley. Before moving to New York in 1976, she worked as art director on Ramparts magazine and was founding creative director of Francis Coppola's City magazine. Kraus won't divulge her age, but it's safe to say she was born in the mid-1940s.
In her book's most fascinating anecdote, Kraus describes a meeting with Richard Nixon in April 1983. The ex-president had written an Op-Ed piece about U.S.-Soviet relations and contacted Kraus to request the original copy of the illustration she drew to accompany his essay. That illustration, sadly, is not in the book.
Nixon was living in New Jersey at the time, with an office at 26 Federal Plaza in New York. Kraus found the unmarked door and was ushered by two Secret Service agents into a "graveyard-sized office." "Then, in the shadowy distance, a figure emerged to incarnate what I'd been drawing - the widow's peak, the jowls, and the nose above dark blue-suited shoulders that drooped like the flag.
"I sat down on his carpeted floor to unzip the portfolio of Op-Ed art that I'd brought." Kraus spent 21/2 hours with Nixon who, alarmed by her informality, tried in his clumsy way to be solicitous. Kraus discovered "someone profoundly ill at ease with himself and others. ... I saw his awkwardness as well as his pain, pride and prickliness."
Kraus left the Times in 2007 to write "All the Art That's Fit to Print," and says she interviewed dozens of artists and former Op-Ed editors in order to tell the full 39-year history of the Op-Ed Page. "I've remained close to all the illustrators. Ralph Steadman, who wrote the foreword, is my very close friend. We talk all the time."
During her years on Op-Ed, Steadman writes in the foreword, Kraus "was always there, clucking away, as Mother Hens do, keeping everyone in line and safe from the foxes. She has the eye of a hawk and the heart of a revolutionary."
Kraus says Op-Ed artwork is "tamer" today than it was in the looser, more experimental 1970s and 1980s. She includes an illustration that Barry Blitt made for a 2007 Frank Rich column, depicting then-presidential candidate Barack Obama as confident and unencumbered and Hillary Clinton as burdened by political "baggage."
Not a caricature
Unlike many political cartoonists, Blitt didn't caricaturize Obama with oversize ears or anything with the potential to offend. Compare that to Blitt's controversial New Yorker cover from July 2008, in which he drew Obama and his wife, Michelle, as the stereotypes imagined by their worst enemies: flag-burning, fist-bumping, gun-toting Muslim terrorists.
The point of the illustration was satire, but many readers didn't see it that way, and the New Yorker received a tidal wave of criticism and canceled subscriptions. The Times, which also canceled a 2008 Blitt drawing of a flag-draped coffin carrying an Iraq war veteran, would probably have not taken that risk.
Kraus still sees the Op-Ed Page and its illustrations as viable and important. Toward the end of the book, she includes an R.O. Blechman drawing that ran three days after the Sept. 11 attacks. Brilliant in its simplicity, it shows the outline of the twin towers piercing a black heart.


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Dating can be hard when you've got kids to worry about. There's a lot of sites out there catering to single parents, but Single Parent Match is the oldest of them and has a great reputation
10/22/2018 · Match.com. If you have already joined a dating game, then you might be familiar with this universal dating site, which has appeared much earlier than most famous applications.It has become a kind of foundation for all subsequent Best Free Dating Sites since 1995.
See experts' picks for the "10 Best Dating Sites of 2019." Compare online dating reviews, stats, free trials, and more. (As seen on CNN and FoxNews).
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Pharmacokinetic Study of PM01183 in Combination With Irinotecan in Patients With Selected Solid Tumors
Status: Active
Prospective, open-label, dose-ranging, uncontrolled phase I study with PM01183 in combination with irinotecan to determine the maximum tolerated dose (MTD) and the recommended dose (RD) of PM01183 in combination with irinotecan in patients with selected advanced solid tumors.
Eligibility Criteria
Inclusion Criteria
- Voluntarily signed and dated written informed consent prior to any specific-study procedure.
- Age between 18 and 70 years (both inclusive).
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≤ 1.
- Life expectancy ≥ 3 months.
- No more than two prior lines of cytotoxic-containing chemotherapy regimens for advanced disease. There is no limit for prior targeted therapy, hormonal therapy and immunotherapy (such as nivolumab).
- Histologically or cytologically confirmed diagnosis of advanced disease of any of the following tumor types:
- Glioblastoma.
- Soft-tissue sarcoma [excluding gastrointestinal stromal tumors (GIST)].
- Endometrial carcinoma.
- Epithelial ovarian carcinoma (including primary peritoneal disease and/or fallopian tube carcinomas and/or endometrial adenocarcinomas) regardless of platinum sensitivity.
- Mesothelioma.
- Gastroenteropancreatic neuroendocrine tumors (GEPNET).
- Small cell lung cancer (SCLC).
- Pancreatic adenocarcinoma.
- Gastric carcinoma.
- Colorectal carcinoma (CRC).
- Expansion phase: Tumor-specific cohort(s) at the RD:
- Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) v.1.1.
- Documented disease progression per RECIST v.1.1 during or immediately after last therapy according to any of the aforementioned criteria.
- At least three weeks since the last anticancer therapy, including investigational drugs and radiotherapy, and at least six weeks since nitrosoureas and mitomycin C(systemic).
- Adequate bone marrow, renal, hepatic, and metabolic function (assessed ≤ 7 days before inclusion in the study):
- Platelet count ≥ 100 × 109/L, hemoglobin ≥ 9.0 g/dL and absolute neutrophil count (ANC) ≥ 2.0 × 109 /L.
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤3.0 × the upper limit of normal(ULN), even in the presence of liver metastases.
- Alkaline phosphatase (ALP) ≤ 2.5 × ULN (≤ 5 × ULN if disease-related/in the case of liver metastases).
- Total bilirubin ≤ 1.5 × ULN or direct bilirubin ≤ ULN.
- International Normalized Ratio (INR) < 1.5 (except if patient is on oral anticoagulation therapy).
- Calculated creatinine clearance (CrCL) ≥ 30 mL/minute (using Cockcroft-Gault formula).
- Creatine phosphokinase (CPK) ≤ 2.5 × ULN.
- Albumin ≥ 3.0 g/dL.
- Recovery to grade ≤ 1 or to baseline from any adverse event (AE) derived from previous treatment (excluding alopecia and/or cutaneous toxicity and/or peripheral neuropathy and/or fatigue grade ≤ 2).
Exclusion Criteria
- Concomitant diseases/conditions:
- History or presence of unstable angina, myocardial infarction, congestive heart failure, or clinically significant valvular heart disease within the previous year.
- Symptomatic arrhythmia or any uncontrolled arrhythmia requiring ongoing treatment.
- Ongoing chronic alcohol consumption or cirrhosis with Child-Pugh score B or C. Known Gilbert disease.
- Active uncontrolled infection.
- Known human immunodeficiency virus (HIV) or known hepatitis C virus (HCV) infection or active hepatitis B.
- Myopathy or any clinical situation that causes significant and persistent elevation of CPK (> 2.5 × ULN in two different determinations performed one week apart).
- Any past or present chronic inflammatory colon and/or liver disease, past intestinal obstruction, pseudo or subocclusion or paralysis.
- Evident symptomatic pulmonary fibrosis or interstitial pneumonitis, pleural or cardiac effusion rapidly increasing and/or necessitating prompt local treatment within seven days.
- Limitation of the patient's ability to comply with the treatment or follow-up protocol.
- Any other major illness that, in the Investigator's judgment, will substantially increase the risk associated with the patient's participation in this study.
- Prior treatment with PM01183, trabectedin (Yondelis®) or topoisomerase I inhibitors (irinotecan, topotecan, etc.).
- Prior bone marrow or stem cell transplantation, or radiation therapy in more than 35% of bone marrow.
- Known brain metastases or leptomeningeal disease involvement. Glioblastoma lesions (primary or locally advanced) are eligible.
- Women who are pregnant or breast feeding and fertile patients (men and women) who are not using an effective method of contraception. All patients (men and women) must agree to use an effective method of contraception (if applicable) up to three months after treatment discontinuation.
Locations & Contacts
Beth Israel Deaconess Medical Center
Status: Active
Name Not Available
Status: Active
Name Not Available
Massachusetts General Hospital Cancer Center
Status: Active
Contact: Gregory Michael Cote
Phone: 877-726-5130
Email: email@example.com
Status: Active
Contact: Gregory Michael Cote
Phone: 877-726-5130
Email: firstname.lastname@example.com
Trial Phase & Type
Trial Phase
Trial Type
Lead Organization
Lead Organization
PharmaMar SA
Trial IDs
Primary ID PM1183-A-014-15
Secondary IDs NCI-2016-01032
Clinicaltrials.gov ID NCT02611024
Secondary IDs NCI-2016-01032
Clinicaltrials.gov ID NCT02611024