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Gorgeous Floral Ring
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If you ever imagine yourself wearing some bling then this is the best craft for you. Create your very own floral ring from AMACO. In only eight steps this ring can be on your finger making all your friends want one.
- Friendly Plastic 7" sticks: in colors of your choice.
- Mat knife
- Non-stick baking sheet that fits flat on griddle surface
- Cutting mat
- Craft knife
- Scissor
- Acrylic ruler
- Needle tool
- 3/4" round shaped cutter:
- Small dish of cold water with a few drops of olive oil
- Griddle set at 200-300 degrees
- Heat tool
- Sealer: I used Envirotex Lite, but any high gloss acrylic sealer will work.
- Disposable mixing container and stir stick
- Straw
- Non-stick cookie sheet
- Adjustable ring blanks
- 3/4" square silver filigree
- Small filigree flowers
- Crystal rhinestones: optional
- E6ooo glue
- Fracture: Using a cutting mat, ruler and blade, cut the plastic sticks into 1/4" and 1/8" strips. Then cut the strips in half using a scissor. Cut enough strips in order to create an interesting color pattern.
- Fusion: Pre heat the griddle. Place the baking sheet onto the griddle. One at a time, in the color pattern shown, or one of your own. place the plastic strips onto the baking sheet. Make sure each strip is stuck in place before adding the next. Try to press each strip tightly against the one before, to prevent any gaps. Continue until all of the strips have been added. Allow the plastic to soften and seal together. If any gaps do appear, simply tap over them with your finger pressing the softened plastic together. When all the strips have softened and sealed together, remove the baking sheet from the griddle and allow the plastic to cool. Use the needle tool to press under the edges of the cooled plastic and remove it from the pan.
- Fracture: Place the cooled plastic back on the cutting mat and trim off the two uneven edges. Continue to cut the plastic into random widths, until the entire piece has been cut apart.
- Flip every other strip in reverse, revealing what the finished fractured pattern will look like. Play around with the different size strips until you have the desired pattern. The finished piece only needs to be larger enough to accommodate the number of circle cut-outs that you want.
- Fusion: Place the baking sheet back onto the griddle. One at a time, in the pattern you have arranged, place the plastic strips onto the baking sheet. Make sure each strip is stuck in place before adding the next strip. Try to press each strip tightly against the one before, to prevent any gaps. Continue until all of the strips have been added. Allow the plastic to soften and seal together. If any gaps do appear, remember to tap over them with your finger pressing the softened plastic together. When all the strips have softened and sealed together, remove the baking sheet from the griddle.
- While the plastic is still warm, cut the circles by pressing the cutter into the softened plastic. Dip the cutter back into the cold water after each cut. This will help keep it from sticking to the plastic. Allow the plastic to cool. You may place the pan under cold running water to speed the cooling process along. Use the needle tool to press under the edges of the cooled plastic and remove it from the pan. Pop out the circles. If needed use the craft knife to cut around each one.
- Mix the Envirotex lite sealer following the manufactures instructions. Application: I like to place my pieces on a non stick cookie sheet. This way if there is any run off, it will be easy to remove later. Once I have the Envirotex mixed, I like to pour it into a small squeeze bottle. The application will be more precise and much easier. Once the resin has been applied, blow softly through a straw over each piece to pop any bubbles that remain. Allow the pieces to dry at least 12 hours. If there has been any run off. Remove the piece from the pan by pressing the needle tool under it and lifting. The resin is still soft enough that you can cut the excess off with a scissor. Envirotex cures completely in 24 hours.
- Position and glue the filigree square onto the ring blank. Next glue the plastic circle into the center of the filigree. Finish by adhere the filigree flower onto the center of the friendly plastic circle. Add a crystal rhinestone if desired. Allow the glue to dry.
Variation: Try using different color combinations and different types of filigree designs to create your very own unique look.
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Brokaw: 'The system is rigged'
NBC News's Tom Brokaw has a simple explanation for what's wrong with Washington.
"The fact is the system is rigged," he said Sunday on NBC's "Meet the Press."
"Seventy-five percent of the congressmen come from gerrymandered districts in which they're bulletproof. They only play to one constituency. There are no swing states. They don't go home and have to prove their case, because they've got a choir back home. And that's a huge part of the problem here."

subset: commoncrawl


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VMware vSphere Replication is a hypervisor-based, asynchronous replication solution for vSphere virtual machines. It is fully integrated with VMware vCenter Server and the vSphere Web Client. vSphere Replication delivers flexible, reliable and cost-efficient replication to enable data protection and disaster recovery for all virtual machines in your environment.
Use Cases
vSphere Replication at Work
vSphere Replication provides flexible recovery options, ensures consistent application and virtual machine data, and it integrates with the VMware product stack. vSphere Replications allows you to:
vSphere Replication is a hypervisor-based replication solution that operates at the individual virtual machine disk (VMDK) level, allowing replication of individual virtual machines between heterogeneous storage types supported by vSphere. Because vSphere Replication is independent of the underlying storage, it works with a variety of storage types including VMware vSAN, vSphere Virtual Volumes, traditional SAN, network-attached storage (NAS), and direct-attached storage (DAS). This allows you to:
vSphere Replication copies only changed data to the recovery site to lower bandwidth utilization, improve network efficiency and enable more aggressive RPOs than a manual, full-system copy. With vSphere Replication, you can:
vSphere Replication is a deeply integrated VMware vSphere component. It is a robust hypervisor-based virtual machine replication engine. Changed data in virtual machine disks for a running virtual machine at a primary site is sent to a secondary site. There, the changes are applied to the virtual machine disks of the offline copy (replica) of the virtual machine.
vSphere Replication includes an agent built into vSphere and one or more virtual appliances deployed using vSphere Web Client. The agent tracks and sends changed data from a running virtual machine to a vSphere Replication appliance at a remote site; the appliance then adds the replicated data to the offline replica copy for that virtual machine. The vSphere Replication virtual appliance also manages and monitors the replication process. This gives administrators visibility into virtual machine protection status and the ability to recover virtual machines with a few clicks.
It's easy to configure replication for up to 2,000 virtual machines using vSphere Web Client: select one or more virtual machines, right-click on a virtual machine, and define the RPO and destination for its replica. vSphere Replication will then replicate data to meet the RPO at all times, ensuring that virtual machine content never ages past its defined replication policy. RPOs range from 5 minutes to 24 hours and can be configured on a per-virtual machine basis.
vSphere Replication can do an initial full synchronization of the source virtual machine and its replica copy. If desired, a seed copy of data can be placed at the destination to minimize the time and bandwidth required for the first replication. A seed copy of a virtual machine consists of a virtual machine disk file that can be positioned at the target location. A seed copy is manually created and placed at the recovery location using any mechanism the administrator chooses, such as offline copying, FTP, an ISO image or a virtual machine clone.
After the initial full synchronization is complete, vSphere Replication will transfer only changed data. The vSphere kernel tracks unique writes to protected virtual machines, identifying and replicating only those blocks that have changed between replication cycles. This keeps network traffic to a minimum and allows for aggressive RPOs.
The virtual machine replication process is non-intrusive and takes place independent of the operating system or applications in the virtual machine. It is transparent to protected virtual machines and requires no changes to their configuration or ongoing management.
Configure Replication
Recovery Settings


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Disney continues to stand behind their answer to the Pokémon, releasing a series of junior novels based in the Spectrobes universe.
Disney's enthusiasm for the series they had created from the ground up is admirable, and there tenacity is something to see. They aren't just fostering a video game franchise, but attempting to sow the seeds of entertainment sensation, watering it now and again with new game releases and tie-ins. One such tie-in actually launches today, with the first two young adult novels in the Spectrobes series already in stores.
Spectrobes: First Contact and Spectrobes: Rise of the Ancient follow the storyline of the first two Nintendo DS titles, and are both available for purchase today wherever fine reading materials are sold. The next book is Spectrobes: Origins, which is being released in August, just before its namesake hits the Nintendo Wii. The fourth book, Spectrobes: The Ultimate Returns, is due in stores November 3.
"The Spectrobes video game franchise has been incredibly successful with the handheld releases the past two years and the anticipation of the first Wii game, Spectrobes: Origins, this fall," said Craig Relyea, senior vice president of global marketing, Disney Interactive Studios. "As an original video game property, Spectrobes is expanding to excite audiences in new ways. The four junior novels are the perfect initial step in growing the Spectrobes franchise."
Did he say "initial step"? That sounds a little ominous, doesn't it?


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We believe elevating where you live is about blending it seamlessly with how you live. We go to great lengths designing amenities and choosing locations that put everything within reach. Where you live, is where you come alive.
Set amongst the lush greenery near the banks of Nagog Pond, Avalon Acton offers lovely Acton apartments for rent in a serene suburb of Boston. Our Acton apartments come in one- and two-bedroom designs including Contemporary and Urban Flats and loft homes. Each floor plan has been meticulously constructed with gourmet kitchens boasting premium appliances, spacious closets, and other fantastic amenities. Our selection of beautiful homes also offer a vast array of exciting community features like a sparkling outdoor pool and nearby patio, an indoor basketball court, and so much more. The serene woodland views complete the experience of this picturesque, quiet neighborhood. In short, our Acton apartments give you a great location, award winning customer service and the most sought-after amenities in any community in Massachusetts. Read More
Avalon Acton allows you to live comfortably in town while still being conveniently close the city life of Boston. Residents of our Acton apartment community will find easy access to plenty of delectable restaurants, exquisite shops and some of Massachusetts' finest parks, conservations and wildlife reserves. You can spend a day with your family exploring an interesting array of exhibits at the Discovery Museum or take time off with friends at the Quail Ridge Country Club. Our Acton apartments' are also located close to Boston, Cambridge, Lowell and the surrounding areas.
The Avalon Advantage is an exclusive set of privileged benefits available to all our residents. We offer you a 30-day move in satisfaction guarantee, 24-hour maintenance, flexible lease terms, a national transfer or relocation program, as well as many more advantages that are unique to members of the Avalon community. Here at Avalon Acton, you get the perfect blend of luxury and comfort to cater to all your needs.
So what are you waiting for! Click the Contact Us button below and discover these amazing Acton apartments today!
Learn More
View Pet Policy
Learn More
Show me more.
Your pets are part of your family. That means finding a home that welcomes all of you. We couldn't agree more, which is why we are a pet-friendly community and created WAG The Pet Program to take pet-friendly living to the next level.
Cats and dogs are welcome! Please check the dog breed and pet restrictions below.
Max of 2 Pets Allowed
Max Weight Limit: N/A
AvalonBay Communities reserves the right to deny residency to any animal deemed aggressive whose breed is not explicitly listed. Should your pet injure any other pets, residents or AvalonBay Communities associates, you will be asked to remove the pet from the premises immediately.
Pets must be on a leash at all times when outside the apartment home. If applicable, dogs must be leashed whenever entering and exiting the Pet Park, but may be unleashed while within the enclosure of the Pet Park.
The following breeds are restricted:
* Other pets may also be restricted. Please contact our community for details.
For Residents: Parking is unassigned and free for current residents. Garage spaces can be rented for an additional monthly fee.
For Future Residents: Parking is free for future residents who take a tour of our community. Please park in the designated spaces, located in front of the Leasing Office.
For Guests: Guest parking is unassigned and free. No parking permits or passes are required.
Smoking is not permitted at this community.
Maybe you want room to entertain. Maybe you're going for class without the extravagance. Maybe you'll know when you see it. So look around, and make yourself at home.
This floor plan is currently not available - please sign up for an email below to receive notice when this floor plan has an available unit.
I would like to be alerted when the following apartment(s) become available:
If you already know exactly which apartment is right for you, you can use this form to jump straight to it.
Find more Avalon locations and other properties designed by the people that bring you Avalon, here.
You've put a lot in to get where you are. You deserve the freedom to enjoy it. So go ahead. Shed the hassles of ownership without sacrificing the comforts of home. Rent to live. Avalon style.
Affordable Housing options are available. Click here for more information.
Cats and dogs welcome! Check out WAG The Pet Program and see what we do to take pet-friendly living to the next level.
We partnered with CORT Furniture to make it easier for you to actually live in our apartment homes even when you can't have your own furniture come along.
Everyone has their own definition of a healthy lifestyle, so we offer a variety of spaces and places, information and inspiration, and some little extras to help you find your fit.
Your pets are part of your family. That means finding a home that welcomes all of you. We couldn't agree more, which is why we offer pet-friendly communities across the country and created WAG The Pet Program to take pet-friendly living to the next level.
Change is inevitable. Should it happen to your apartment needs, you'll get to keep the standard of service you expect at any one of our communities, with additional perks to smooth your transition.


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Discover a new concept in hair coloration that gives you healthy and revitalised hair. Discover Naturtint Green Technologies, the first 100% permanent hair colorant without amonia formulated with active vegetable ingredients. A unique and perfect union of colour and care.
Maximum CareAmmonia and Resorcinol Free
- Formulated without ammonia or resorcinol, colours your hair gently so you won't need to resort to repair treatments to keep your hair looking great. What's more, its ultra-mild formula allows you to use Naturtint as often as you need to touch-up roots.
- It's active plant ingredients protect and regenerate hair fibres, bringing back lost vitality and shine, even in hair damaged by aggressive colouring processes and threatments
- The Nutrideep Multiplier deep conditions and nourishes your hair giving it 3 times it's normal strength and volume. Hair fibres appear smooth and soft, bringing back the healthy shine of young, unspoilt hair.
Maximum Colour100% Coverage
- It's revolutionary formula provides 100% coverage, even of grey hair, permanently, from the first application. It's the first hair colorant that is both healthy and effective.
- Ultra-intense micro-pigments penetrate to the deepest layers of your hair, giving it an intense and vibrant colour that won't fade with washing.
- The powerful vegetable-based, solar-enhanced filter provides increased protection against the elements, letting your hair maintain it's intense colour for up to 5 weeks.
* [1] Note: Unless otherwise noted, this product has not been evaluated by the Food and Drug Administration. Our natural products are not intended to diagnose, treat, cure, or prevent any disease.


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Mycraftwork evolved naturally out of the desire to promote the Moroccan Design in the United States.
Started in 2007, Mycraftwork, is run by two brothers born and raised in Morocco. The younger brother, Tao, settled in the US, working in Massachusetts as an Engineer. While Houssine decided to stay in Marrakesh to pursue a career as the CFO of a large resort hotel group. It was through this hotel group that Houssine ended up building an extensive network in the Moroccan Design arena. Together, these brothers got an idea. It seemed simple: We will design high quality, handmade, Moroccan goods, tailored to the American Market.
Tao led a market research campaign and he found a lot of retailers that specialized in reselling handmade Moroccan items, but he couldn't find a single business that could actually carry out the entire creation cycle, from the design and conception, to the finished product. Houssine began to engage the most skilled artisan cooperatives in experimental projects. So the brothers would design goods (rugs and pottery mostly) and track these works of art as they progressed through the artisans co-op. Amazed by the quality of the finished crafts, they realized that by empowering the artisans, they could become pioneers in the field of custom-designed handmade Moroccan crafts.
Passionate about the beauty of Moroccan designs and eager to share the beauty of these creations with you, Tao and Houssine are working tirelessly at expanding their product portfolio. So go ahead, make yourself at home and don't forget to contact us with any questions or suggestions.
Founder and Managing Director
MyCraftWork, LLC


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50 results
A third party software for Sketchup (windows explorer thumbnailer, mesh optimizer...)
Add scenes orthographically by entering x,y,z offsets
With AR-media™ Plugin you can visualize 3D models using Augmented Reality directly in the real physical space which surrounds you.
Bulk reset of group and component's axes.
A tool to create Bézier curves.
A tool to create Bézier curves that pass through user selected data points
A tool to create and edit nonrational and rational Bézier triangle surfaces.
Explodes all groups and components in model
Turn loose geometry into groups
Context menu access to component properties.


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The Stateline Gem & Mineral Society's 48th annual Jewelry, Rock, Gem and Mineral show is scheduled June 5, 6 and 7 in the Junior Fair Building at the Fulton County Fairgrounds. This year's theme is "Rocks: their Myths and Legends." Admission is free.
Educational demonstrations are planned throughout the weekend including cabochon cutting, silver casting, soapstone carving, flint knapping, beading, wire wrapping, spool knitting, faceting and glass fusing.
Rock, mineral, fossil and crystal collections will be on display, a bead rally is planned, and dealers will be on hand. Children's activities are also scheduled.
The show will be open from noon to 7 p.m. June 5; from 10 a.m.-7 p.m. June 6; and from 11 a.m. to 4 p.m. June 7.
The Fulton County Fairground is located on State Route 108, north of the Ohio Turnpike, in Wauseon.


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Fierce wind forces closure of Olympic Park in South Korea
GANGNEUNG, South Korea (AP) — Sharp, gusting wind forced the temporary closure of the Olympic Park in Gangneung on Wednesday, the latest blow from wild weather that has affected the games for several days.
Sustained winds of 23 mph (37 kph) with stronger gusts howled through the Olympic Park near the coast, knocking over tents, signs and even small refrigerators. The conditions have repeatedly forced the postponement of events in the mountains to the west, notably Alpine skiing.
Local officials began evacuating Olympic Park at about 3 p.m., with public address announcements in Korean and English urging spectators to go indoors and eventually a police presence helped clear the area. Many spectators sought shelter in buildings near the Gangneung Hockey Centre. Normal activity resumed several hours later, before speedskating and hockey events were scheduled to being.
Inside the Gangneung Oval, home to long-track speedskating, Dutch oompah band Kleintje Pils had some fun with windy conditions by opening their performance with "Stormy."
There has been much discussion of the cold conditions at these Olympics, but temperatures had moderated on Wednesday — only for the wind to cause more disruptions. Gusts topping 45 mph have forced the postponement of three of four scheduled Alpine ski races, the latest coming Wednesday as the women's slalom was pushed back until Friday. The women's biathlon at Alpensia Biathlon Center was also postponed, until Thursday.
With ski racing, the wind can make it dangerous for athletes already traveling at as much as 75 mph; in technical events, such as the slalom, wind that changes direction can be considered unfair, because some skiers will get a helpful tailwind, while others will be hurt by a headwind.
"All of them are anxious to race, absolutely, but they all want to race in fair conditions. That's the main thing," U.S. women's Alpine coach Paul Kristofic said after the slalom was called off. "To have unstable wind like that for one racer and not for the other, it creates not the best sporting event."
Gusts of more than 15 mph pushed the women's biathlon back because that much wind makes it difficult for competitors to properly handle their rifles.
Indoor sport competitions weren't affected, but conditions surrounding some of the venues were treacherous. Several venue media centers, giant tents anchored with metal beams, were closed temporarily.
AP Sports Writers Beth Harris and Teresa M. Walker in Gangneung, South Korea, and Howard Fendrich in Pyeongchang, South Korea, contributed.
More AP Olympic coverage: https://wintergames.ap.org


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EMERALD: Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes (EMERALD)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01808690
Recruitment Status : Completed
First Posted : March 11, 2013
Last Update Posted : July 18, 2018
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Diabetes is increasingly common among youth, forecasting early complications. Type 1 (T1D) cause early heart disease, shortening lifespan despite modern improvements in control of blood sugars and other risk factors for heart disease. Poor insulin action, otherwise known as insulin resistance (IR), is the main factor causing heart disease in type 2 diabetes (T2D), but the cause of increased heart disease in T1D is unclear. IR may contribute to heart disease in T1D as in T2D, as the investigators and others have found the presence of IR in T1D. Much less is known about IR in T1D, but a better understanding of its role in T1D is critical to understanding causes of heart disease in T1D. The investigators long-term goal is to understand the early causes of heart disease in diabetes so that we can prevent it. The investigators unique initial findings suggest that even reasonably well-controlled, normal weight, T1D youth are IR. The IR appears directly related to the heart, blood vessel, and exercise defects, but in a pattern that appears very different from T2D. The goals of this study are to determine the unique heart, blood vessel and insulin sensitivity abnormalities in T1D youth, and determine whether metformin improves these abnormalities. A clear understanding of these factors will help determine the causes, and what treatments could help each abnormality.
Hypothesis 1: Metformin will improve insulin function and mitochondrial function in T1D.
Hypothesis 2: Metformin will improve vascular and cardiac function in T1D.
All measures will be performed twice, before and after a 3-month randomized, placebo-controlled design where subjects are randomized to either metformin or placebo. The independent impact of insulin action as well as glucose levels, BMI, T1D duration, and gender on baseline outcomes and the impact of changes in insulin action, glucose levels and BMI on response to metformin will also be examined to help customize future strategies to prevent heart disease in T1D. This study will advance the field by providing new information about the role of poor insulin action in the heart disease of T1D, and whether improving insulin action in T1D is helpful. If a focus on directly improving insulin action in T1D youth is supported by our studies, the clinical approach to T1D management may significantly change.
|Condition or disease
|Type 1 Diabetes
|Drug: Metformin Drug: Placebo
|Phase 3
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|52 participants
|Intervention Model:
|Parallel Assignment
|Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|Primary Purpose:
|Official Title:
|Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes
|Study Start Date :
|March 2013
|Actual Primary Completion Date :
|December 2017
|Actual Study Completion Date :
|December 2017
Placebo Comparator: Metformin
Metformin will be given at a dose of 1000 mg twice a day orally for three months to assess changes in insulin resistance compared to placebo.
Drug: Metformin
Placebo Comparator: Placebo
Placebo will be given at a dose of 1000 mg twice a day orally for three months to assess changes in insulin resistance compared to metformin.
Drug: Placebo
- Change in Insulin Function [ Time Frame: 3 months ]Hypothesis 1: Metformin will improve insulin function in Type 1 Diabetes. Insulin function will be measured using a euglycemic-hyperinsulinemic clamp procedure at both baseline and after 3 months of treatment.
- Change in Mitochondrial Function [ Time Frame: 3 months ]Hypothesis 1b: Metformin will improve mitochondrial function in Type 1 Diabetes. Mitochondrial function (ADP t1/2) will be assessed by 31 Phosphorous magnetic resonance spectroscopy and peak exercise capacity by VO2peak.
- Change in Central Vascular Function [ Time Frame: 3 months ]Hypothesis 2a: Metformin will improve central vascular function in Type 1 Diabetes via Central arterial stiffness and aortic wall shear stress by MRI.
- Change in Central Vascular Function [ Time Frame: 3 months ]Hypothesis 2a: Metformin will improve central vascular function in Type 1 Diabetes via central arterial intimal medial thickness by carotid ultrasound.
- Change in Cardiac Function [ Time Frame: 3 months ]Hypothesis 2b: Metformin will improve cardiac function in Type 1 Diabetes by echocardiogram.
- Change in Peripheral Vascular Function [ Time Frame: 3 months ]Hypothesis 2a: Metformin will improve peripheral arterial stiffness in Type 1 Diabetes via Dynapulse.
- Change in Cardiac Function [ Time Frame: 3 months ]Hypothesis 2: Metformin will improve cardiac dysfunction in Type 1 Diabetes with the measurement of cardiac function measured using MRI
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|12 Years to 21 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Adolescents 12-21 years of age with type 1 diabetes (defined as having positive antibodies as well as insulin requirement)
- Willing to consent for participation in study
- Body Mass Index (BMI) >5% on growth charts
Exclusion Criteria:
- Current use of medications known to affect insulin sensitivity: oral glucocorticoids within 10 days, atypical antipsychotics, immunosuppressant agents, metformin or thiazolidinediones.
- Currently pregnant or breastfeeding women
- Use of a thiazolidinedione within 12 weeks
- Severe illness or Diabetic Ketoacidosis within 60 days
- Macroalbuminuria
- Hemoglobin A1c > 12%
- Weight > 136.4 kg or < 42 kg, BMI < 5%
- Creatinine > 1.2
- Hemoglobin < 9
- Major psychiatric or developmental disorder limiting informed consent
- Implanted metal devices
- Inability to tolerate ≥500mg twice a day of metformin
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01808690
|United States, Colorado
|Children's Hospital Colorado and University of Colorado Denver Health Sciences Center
|Aurora, Colorado, United States, 80045
|Principal Investigator:
|Kristen Nadeau, MD, MS
|University of Colorado/Children's Hospital Colorado
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|University of Colorado, Denver
|ClinicalTrials.gov Identifier:
|NCT01808690 History of Changes
|Other Study ID Numbers:
R56DK078645 ( U.S. NIH Grant/Contract )
|First Posted:
|March 11, 2013 Key Record Dates
|Last Update Posted:
|July 18, 2018
|Last Verified:
|July 2018
Insulin Resistance
Diabetes Mellitus
Diabetes Mellitus, Type 1
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Autoimmune Diseases
Immune System Diseases
Hypoglycemic Agents
Physiological Effects of Drugs


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Serious Eats Neighborhood Guides: Marc Forgione's TriBeCa
Marc Forgione is the real deal. He's got the pedigree: he started working in professional kitchens alongside his father, esteemed chef Larry Forgione, at age 16. He's got the praise: at 29, his TriBeCa restaurant Marc Forgione was awarded two stars by The New York Times, and he's the youngest American-born chef and owner to receive a Michelin star in two consecutive years. Marc also knows his neighborhood—he doesn't discriminate between the old-line TriBeCa watering holes and the hottest new restaurants, as long as they're good. And he gives back to the area where he works by participating in the Taste of TriBeCa, a culinary festival whose proceeds go to arts and enrichment programs at local public schools PS 150 and PS 234.
Marc was kind enough to take some time out of his jam-packed schedule (he's got his hands full opening a gigantic new oceanfront steakhouse, American Cut, in Atlantic City's Revel Casino) to share his own TriBeCa tastes with us.
Marc's Picks:
Walker's has the best burger in TriBeCa hands down (after ours, of course). It's a good deal at $10.
Puffy's Tavern. It's not well-known, but they serve some of the best fresh Italian sandwiches made to order, from Alidoro in Soho.
Wine bar I love going over to Marco Canora's Terroir after work for a glass of wine and great Italian small plates.
Cocktail bar I love Ward 3, where Abdul, Michael and Kenny are as good as you will find behind the bar. Try one of their classic cocktails or have them create something specifically for you.
Dive bar When we want to go out after service, the staff at the restaurant usually heads over to Raccoon Lodge. They have everything you could want in a dive bar: cheap drinks, a pool table, and a punching machine. My drink order is a Miller High Life.
Cosmopolitan Cafe is one of the best spots in all of NYC. I like to order the Banana Nutella Crepe and an espresso. Ask for Craig, tell him you know us and ask him to see the back room. It is a must-see gem!
Late-night eats Marc Murphy's Landmarc is open until 2am and it's where we like to head for good, late night food after service. Boudin Noir or Chicken Liver are my favorites.
Date night I always enjoy chef Paul Liebrandt's food and Corton is the perfect date-night restaurant for a special occasion. Order the seasonal tasting menu.
Can't-miss neighborhood spot
Locanda Verde for their Eggplant Parmigiano Hero with egg. Also, I had the pleasure of going to Atera early and thought chef Matthew Lightner's food was really innovative.
All products linked here have been independently selected by our editors. We may earn a commission on purchases, as described in our affiliate policy.


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Poll shows Americans conflicted over immigration debate
WASHINGTON — As the immigration debate heads into a crucial period on Capitol Hill, Americans have been convinced.
By both sides.
In a new USA TODAY/Pew Research Center Poll, three of four people agree with big arguments made by proponents of legislation that would allow millions of undocumented workers to stay in the United States legally: that deporting them isn't realistic, that granting them legal status would boost the U.S. economy, that most are hardworking and deserve an opportunity to stay.
At the same time, nearly two-thirds of those surveyed also agree with big arguments made by opponents: that granting undocumented workers legal status would drain government services and that doing so would encourage more foreigners to come to the U.S. illegally.
Just about everybody — more than eight in 10 Americans — endorse views on both sides of the argument. That could make the politics harder when it comes to striking a final deal this year, a time widely seen as the best chance in a generation to overhaul the nation's immigration system.
"I'm a Democrat, and I understand the importance of it, especially to the children of immigrants," Linda Kosinski, 56, a small-business owner from Andover, Mass., said in a follow-up interview after being polled. "But I'm one of those 'the rules are the rules' people. Fundamentally I guess I worry about — if we keep doing this, why would anybody go through the means of becoming a citizen legally?"
"Believe it or not, I'm a registered Republican, but I put it to you this way: People who have been here for years and years, I say legalize them," says Aaron Movtady, 44, a loan officer for a mortgage bank from Bayside, Queens. "Lot of them, they're guys just trying to make an honest living, trying to live the American dream."
The findings illustrate "the level of internal conflict people feel over this policy realm," says Michael Dimmock, director of the Pew Research Center. "Both arguments have been made pretty persuasively at this point."
The poll of 1,512 adults, taken June 12-16 by land line and cellphone, has a margin of error of +/–2.9 percentage points.
The crosscurrents in public opinion could complicate the make-or-break period just ahead in Congress.
In some ways, it could help negotiations to reach a compromise. "When people see both sides of an argument, then the proponents of each side understand the other side is going to be taken into consideration," offers Haley Barbour, a former Mississippi governor and Republican national chairman.
In other ways, it's likely to make it harder. For one thing, it will be difficult to satisfy the sometimes-conflicting priorities that most Americans now endorse, from the demand to tighten the borders (backed by 77%) to the desire to provide legal standing for undocumented immigrants (backed by 71%). For another, negotiators could be emboldened to draw a harder line against giving ground because both sides can argue that Americans are behind them.
In the past few days, there has been progress toward a deal in the Senate but warning signs of the course ahead in the House.
Senate Majority Leader Harry Reid, D-Nev., says he wants the Senate to vote on an immigration overhaul drafted by the bipartisan "Gang of Eight" before the Fourth of July recess. An agreement reached Thursday to bolster the border-security provisions in the measure has helped win over additional Republican senators. However, House Speaker John Boehner last week declared that the legislation brought to the floor there will have to be backed by a "majority of the majority" — that is, by a majority of Republican representatives.
That guarantees the House version, assuming one passes, will be significantly more conservative than the Senate bill. Boehner has signaled it won't include a pathway to citizenship for undocumented workers, even though Democrats describe that as essential, and it's likely to include provisions on border security that the other side already has ruled out as unacceptable. The Senate amendment hasn't quelled his concerns.
"Immigration reform must — I mean must — be grounded in real border security," Boehner said Thursday. "That's what the American people believe."
The most divisive issue in the immigration debate comes down to a question of timing: Half of those surveyed, 49%, say undocumented immigrants should be able to apply for legal status while border-security improvements are being made. Close to half, 43%, say the move to legal status should be delayed until after stricter border security is in place.
"The most important thing is that our citizens along the border between Mexico and the U.S. are in danger," says James Purvis, 28, of Rochester, N.Y., who works in information security and was called in the poll. "My brother lives in Arizona, and it's very much part of his life that he has to worry about being injured or harassed by people at the border."
The issue divides each party into three camps, albeit in different ways.
Among Republicans and Republican-leaning independents, nearly four in 10 say immigrants who are in the U.S. illegally shouldn't be able to remain in the country at all. The remaining Republicans are divided between those who say the immigrants shouldn't be allowed to apply for legal status until borders are under better control and those who say they should be allowed to do so while border security is being improved.
Among Democrats and Democratic-leaning independents, four in 10 say undocumented workers should be able to apply for legal status while border security is being tightened. The remaining Democrats are divided between those who say the legalization process shouldn't begin until the borders have been made more secure and those who say border security shouldn't even be part of the new immigration law.
"They talk so much about it, but they need to do something," says Ramona McEwen, 52, a home health aide from Muskegon, Mich. "It's time. The ones that are already here, already established their families, their jobs, they should be able to stay here instead of go back. I think that's only fair."
Precisely half of those surveyed say it is extremely or very important to them that the president and Congress enact significant immigration legislation this year. Another one in three say it is "somewhat" important to them. Just two in 10 say it isn't important.
The level of interest in and support for a bill is significantly higher than it was almost precisely six years ago, in June 2007, the last time the Senate was headed to a vote on a major immigration bill. At that time, a USA TODAY/Gallup Poll found that 58% of those surveyed didn't know enough about the measure to have an opinion. Those who did have a view opposed it by nearly 3-1, and opponents were much more likely to feel strongly about it than supporters.
Then, the bill failed in the Senate.
Now, there's modest confidence now that Congress will pass a bill that President Obama will sign. Fourteen percent of those surveyed by the Pew Research Center say it's very likely legislation will be signed this year; 39% call it somewhat likely. Forty-four percent say it's not likely to happen.
"I do want them to pass the bill, but I have reservations about whether they will," says Michael Scruggs, 49, a financial analyst who lives near Phoenix. "Immigration is like drug enforcement, OK? Like the war on drugs and the war on terror. It's all sound bites."
Many of the policy issues today are the same as those debated the last time around, but there has been at least one big change —and that has given an immigration bill brighter prospects than it had six years ago.
"What is very different is the focus on Latino voters that came out of the 2012 election," says Matt Barreto, a political scientist at the University of Washington, Seattle, who studies Latino voting behavior. "The 2012 election showed the number of Latino voters continuing to increase and in key states. ... Finally the Republican Party is getting the message: This is a monumental issue for Latino voters, and it's one in which they will evaluate the Republican Party."
In 2012, Republican presidential candidate Mitt Romney received just 27% of the Latino vote, according to surveys of voters as they left polling places.
"The Republican Party really in this last election didn't do anything for the Latino vote, and when they tried to do some ad campaigns it became a laughingstock," recalls Stephanie Stenner, 23, a coffee shop barista from Santa Cruz, Calif., who is Hispanic. "A lot of Latinos are very conservative, and the Republican Party could have such a huge opening for what they stand for with Latinos. But this immigration issue is really hurting them."
Those who aren't Latino are skeptical that passing an immigration bill will do the GOP much good politically. About two-thirds of non-Hispanics say it won't make much difference or might even hurt Republicans.
Among Hispanics, however, 55% say passing an immigration bill would help Republicans in national elections. Seven of 10 Latinos say it's extremely or very important to them that immigration legislation pass this year. Nine of 10 say there should be a way for undocumented immigrants to stay in the United States legally, if certain requirements are met.
So do seven in 10 Americans overall. Asked about what those requirements might be:
• 76% say they should be required to speak and understand English before applying for legal status.
• 56% say they should have to pay fines.
• 55% say there should be a 10-year waiting period before they could become permanent residents.
"The U.S. needs more people, and we need them to be legal so they can pay taxes," says Alfredo Mesa Moreno, 29, a field scientist in Tampa who legally immigrated from Spain and hopes to become a U.S. citizen next year. "But with this law — it can be like a call for immigrants to come here illegally," he worries, then adds: "I guess it's complicated."


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Mountain Dew® and TEN made the highly-anticipated announcement today that the first stop of the 2016 Dew Tour will be held in Long Beach, Calif. on July 23- July 24, at the Long Beach Convention and Entertainment Center. There they will host a brand new skate-specific event, building on the deep history of the culture of skateboarding in Southern California.
With preeminent action sports media company TEN (TRANSWORLD SKATEBOARDING, TRANSWORLD SNOWBOARDING, NEWSCHOOLERS, POWDER, SNOWBOARDER, GRIND TV) now leading the charge, the Dew Tour will have a revolutionary contest format that combines individual contests with a new team competition that will highlight creativity and style above all else. The new Dew Tour has been completely reimagined to focus on more authentic stories year-round and ongoing digital content for its fans on its new site dewtour.com.
"There is so much happening in Long Beach with skateboarding right now that it felt right to host the summer event there. It is also a great centralized location for both LA and OC residents that want to experience Dew Tour," said Adam Cozens, Vice President and General Manager, TEN. "We are looking forward to collaborating with the Long Beach community to host a unique summer event that will celebrate the city's rich history in music, arts, culture and skate."
In addition to the new location, the contest will now feature an all-new team competition on Sunday, July 24 where nine teams made up of 36 of the world's best skaters will face off against each other. For those traditionalists, the individual competition will still be an important part of the event with individual skaters battling it out on Saturday, July 23.
"We are excited to deliver new and progressive skate contest formats and enhanced consumer experiences at Dew Tour this year with TEN's leadership and expertise, and Mountain Dew's continued devotion to driving progression within action sports," said Greg Lyons, Senior Vice President of Marketing, Mountain Dew. "Our goal is to continue to celebrate skateboarding and bring the culture of the sport to life through creativity and community. Long Beach provides us with the perfect backdrop, as the city is deeply rooted in skateboarding and its lifestyle."
"It was important to us to honor skating's roots while still bringing something new and different to the table. The team contest was designed to celebrate the style, creativity and fun of the sport while the individual skate contest stays true to its core," said Chris Ortiz, Dew Tour's managing editor.
On May 3, the new dewtour.com will launch with an explosion of digital content around the new team format, course info, competing athletes and more. For now, watch DEW athlete Sean Malto skate his favorite spots in the LBC here.
TEN's vision for the new Dew Tour has been a collaborative effort as the media company has been able to tap into its legacy action sports media brands including TRANSWORLD SKATEBOARDING, TRANSWORLD SNOWBOARDING, NEWSCHOOLERS, POWDER, SNOWBOARDER and GRIND TV to help shape authentic yet evolved summer skate and winter ski and snowboard events. The world-class competitions will be a constantly shifting action-sports platform of creativity and progression with the support of Mountain Dew, TEN and broadcast partner NBC Sports. The Dew Tour will offer exciting live experiences and captivating content for television, web, social and other digital verticals for fans around the world to enjoy.
More details on Dew Tour's winter event location and dates will be revealed over the coming months.


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Undergraduate Curriculum
A new undergraduate core curriculum went into effect with the Fall 2007 entering class. This new curriculum provides greater flexibility, while focusing on six important outcomes of a College of Science education. We invite you to learn more about the planning process that led to the new curriculum.
How will the new curriculum affect you?
If you are already a College of Science student (entered prior to Fall 2007), you have the option of continuing with the previous curriculum or using the new one. You should speak with your advisor before making this decision.
Regardless of which major you follow in the College of Science, there are core requirements that need to be completed. Those core requirements are determined by the time you begin (or began) your study in the College of Science. The links below will take you to pages describing the core requirements that apply to you.
When did you enter Purdue University?
For incoming students, please read the information below about the outcomes. You may click on an outcome title for more information about it.
Outcomes for a College of Science Education
(Click on any outcome for more information.)
- Demonstrated depth in major
As the principal outcome, CoS students will receive the best education possible in their major -- including a firm grounding in the fundamentals, the most recent developments, and the foundations for future innovations and change.
- Ability to think and function as a scientist
CoS students will develop critical thinking and analytical abilities from their major and by completing a two-course sequence and related laboratory experiences in a science outside of their major in addition to required Mathematics, Statistics, and Computer Science courses. CoS students will delve into Great Issues in Science through a course that addresses the impact of Science on society and the ethical issues that arise.
- Ability to communicate well, both orally and in writing
CoS students will be proficient in technical writing and technical presenting (describing technical information clearly and logically, making strong and persuasive arguments). This outcome can be satisfied by course work, research experiences, or internships and will prepare students for future class work and successful work experiences.
- Ability to collaborate as part of a team
CoS students will learn the concepts involved in Teambuilding and Collaboration, such as leadership, developing shared goals, and utilizing strengths of team members. These foundations will allow students to enter collaborative situations, such as lab groups and study sections, fully prepared to maximize the value of their educational experiences as well as develop positive working relationships with their fellow students. These foundations and experiences can be satisfied by course work, lab courses, research experiences, or internships.
- Ability to function in a multidisciplinary setting
CoS students will have the experience of examining and solving a problem using the tools, techniques, and practices from more than one discipline. This experience will come through a course, research project, or internship, or by graduating with a minor or double major in another discipline.
- Demonstrated breadth of knowledge and cultural appreciation
CoS students will have an understanding of at least one other culture in addition to their own through learning a language, taking culture courses, taking diversity courses, and/or participating in a Study Abroad experiences. This will lead to a greater appreciation for diverse experiences, thoughts, and backgrounds. Students will gain insights in the Humanities, Social Sciences, and/or Management through general education courses in those areas. The Great Issues in Science course will also contribute to this outcome by an exploration of the possibilities of Science and the ethical implications.


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The San Jose Earthquakes held another successful Xfinity Clinic for youth soccer players at Santana Park in San Jose on Tuesday. The clinic was coached by Earthquakes players Chris Wondolowski, Jason Hernandez, Brad Ring, Steven Beitashour and Chris Leitch as well as members of U.K. International Soccer Camps.
One-hundred youth soccer players from San Jose attended the clinic, including several full teams. The youth players ranged in age from six to twelve and were split into groups according to age. The groups took turns rotating around different drills, each coached by an Earthquakes player. The children enjoyed the different drills that included dribbling, passing, one-on-one, and small-sided scrimmages.
The afternoon concluded with an autograph session and each participant receiving one ticket to the Earthquakes next home game versus the Chicago Fire on Wednesday, September 29th at 8 p.m. PT.


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What about us
as in Paradise
...the property is simply wonderful, very well cared for, and very comfortable. The staff is friendly and qualified, the cuisine is delicious: refined but at the same time delicate. A real showpiece. The park and setting are charming, ideal for indulging in a relaxing break and meditation. Highly recommended, absolutely a place to come back to, as soon as possible...
The Relais San Clemente is excellently located!... and access is easy.
Calculate your route to Relais
Main connections by car:
The Relais San Clemente is two kilometers from the Bosco-exit going left to Ramazzano
(open map).
by aeroplane::
Main connections by train: Terontola-Perugia coming from Firenze-Roma or Foligno-Perugia coming from Ancona-Roma. Perugia-Fontivegge railway station is 10km from the Hotel (timetable).
Ramazzano - Strada Passo dell'Acqua, 34 - 06134 Bosco PERUGIA
Special Offers


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Tracy Fells
Tracy Fells lives close to the South Downs in England. After a career in Clinical Research she now writes full-time, embracing her love of magical realism and folk lore. Her short stories have been widely published and shortlisted for competitions such as Fish, Willesden Herald and the Brighton Prize. Having graduated from Chichester University with an MA in Creative Writing she is seeking publication of her debut novel and short story collection.


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The killing on January 11 of a French TV reporter has sent a chill through the international press corps trying to cover the violence in Syria. Gilles Jacquier, 43, who was on assignment for the French public service channel France 2, was a seasoned journalist and the laureate of France's most prestigious journalism prizes. As a special reporter for "Envoyé special," France's equivalent of "60 Minutes," he had covered dozens of wars, from Kosovo to Afghanistan, and was considered one of the most professional French war correspondents.
On Wednesday he had travelled with a group of French, Swiss, Belgian, and Dutch journalists to the Western city of Homs, the epicenter of the rebellion, where they had been put under the tight supervision of members of the Syrian security forces.
How could such a tragedy have happened? "The Nouzha neighborhood is entirely Alawite (President Assad's community) and it is totally controlled by the army and the chabiha, the armed civilian militias in the pay of the regime," Christophe Ayad observed in Le Monde.
On Thursday, citing a source close to President Nicolas Sarkozy, the Paris daily Le Figaro went further and wrote that French authorities were "suspecting a manipulation on the part of the Syrian government." "The Syrian officials were the only ones to know that a group of Western journalists were visiting Homs on this day and in which neighborhood they were," the high-level source said, according Le Figaro. "You can of course think of an unhappy accident. But it comes rather well for a regime that tries to discourage foreign journalists and to demonize the rebellion." Claims of government manipulation of media, often bolstered by video footage, have long been made by the protesters and their supporters.
In the tense and confused moments that followed the attacks, Gilles Jacquier's companion, photographer Caroline Poiron, refused to hand the corpse over to the Syrian security services and only agreed that a limited autopsy be practiced in Damascus. Keeping control over the autopsy was deemed crucial: "A serious forensic examination might help identify the nature of the shells that hit Gilles Jacquier," Philippe Gelle noted in Le Figaro. "If the insurgents are known to use RPG rocket-launchers, it is not sure that they have or know how to use mortars to the point of being able to concentrate four shells on the same target."
Similar press trips had been organized earlier by Sister Agnès-Mariam de la Croix, abbot of the former monastery of Qara and a Lebanese citizen of Palestinian origin with close relations to the Assad regime and connections to Christian circles in Western Europe, particularly in France and Belgium. The trips seemed to provide at least some access to the violence in Syria and a measure of safety.
These invitations, however, had triggered a contentious debate among journalists on the ethics and propriety of being embedded with Syrian security forces accused of massacring civilians. Sister Agnès-Mariam de la Croix was clearly pushing the official line that the "terrorists" were Islamic extremists bent on overthrowing a regime that she described as a protector of Christian minorities in Syria.
Some journalists had refused the invitation because they feared they would get a slanted view of the violence or would be used as stooges for the government's propaganda in Syria. Others went, convinced it was a rare opportunity to get into the country and cover the troubles, at least from the official side. Since the beginning of the revolt international journalists have tried to enter Syria, but soon after the first signs of unrest redolent of a revolution, the government had imposed a nearly complete blackout on the media and rejected most visa applications from Western journalists. (Local journalists, meanwhile, have been detained, gone missing, or turned up dead). The only alternatives were sneaking into the country either on a tourist or business visa, or crossing from Lebanon and going underground or "embedding" with rebel units. Only recently did Damascus start issuing short-term visas for a limited number of journalists, who are allowed to move around only when escorted by official minders.
In any case, most European journalists came to Syria with a deep suspicion of the government. They knew that the Assad regime was waging a crude propaganda war, brandishing the specter of al-Qaida, accusing the West and Israel of subverting the country, stage-managing public events, manipulating video images, and relaying its positions on the Web via so-called "re-information" sites like Infosyrie or "anti-imperialist organizations" denouncing the "international plot against Syria."
Western reporters were also aware that some of the bombings sowing death in pro-Assad neighborhoods in Damascus recently were rumored to have been carried out by the government's own undercover forces.
In such context, were foreign journalists the victims of the regime's dirty tricks? Nick Robertson, a CNN reporter who was with another group of journalists in Homs on the day of Gilles Jacquier's killing, stated that the "bombing is a military operation."
"Rather curiously," adds Alain Lallemand, an international investigative journalist with the Brussels daily Le Soir, "some reporters have pointed out that Sister Agnès did not take part in the trip and stayed away in Damascus. Even more worrying, although they were in Damascus, journalists from countries supportive of the Syrian regime were not invited on this trip."
Dutch photographer Steven Wassenaar, who was lightly wounded in the Homs bombing, confirmed that Sister Agnès had not joined the group. "We were effectively on our own until we arrived in Homs where we were taken charge of by the security services," he said.
"There is no hard evidence," Le Soir Middle East editor Baudouin Loos wrote on Thursday, "so there can be no definite accusations. But if we wonder about who benefits from the crime, we should turn inquisitively to the regime: Damascus will be able to refer to this act to show to the face of the world 'the ignoble methods committed by these barbarians that attack innocent journalists.' Meanwhile the very few colleagues that succeeded in entering Syria will certainly think twice before returning. Syrian authorities do not like witnesses."
On Friday, France Télévisions news director Thierry Thuillier added to the suspicions when he said in an interview that Gilles Jacquier and his cameraman "had not wanted to go to Homs" and had been told they would have "to leave Syria immediately if they refused to go there."
"For us, this scenario raises many questions about the origin of the shots, the target aimed at," added Thuillier. "These journalists were part of a convoy under an escort - very tightly contained. When the firing started, the Syrian soldiers backed away, leaving the journalists exposed and alone. Why? I don't have the answer. The editorial staff, France Televisions (and) the families want this answer."
The French authorities are determined to know what happened. On Friday, a Paris prosecutor launched a preliminary murder investigation into the killing. French Foreign Minister Alain Juppé asked for a thorough and independent probe, and received the full backing of Sarkozy, who in a strong and emotive address paid tribute to Gilles Jacquier and highlighted "the importance of having, in regimes and situations like these, courageous people that are committed to tell the truth of what is happening."
UPDATE: On July 17, Le Figaro, referring to sources close to the French ministry of defense and secret services, wrote that Jacquier had been hit by a mortar shell launched by rebel forces from a position located in a Sunni neighborhood. This thesis, noted Georges Malbrunot, the author of the article, "confirms the information published by Le Figaro one week after the incident, on the basis of a declaration of a human rights activist in Homs who said, 'We made a big blunder,' as well as the conclusions of a senior official of the Arab League, which had at that time observers on site in Homs." According to Le Figaro, a more detailed dossier has been written by the Arab League, but has not been made public.
The newspaper added that the Paris prosecutor in charge of the judicial enquiry quickly adopted the thesis of a "blunder" by the rebels. However, the prosecutor has not been able to travel to Syria to carry out its own investigation and, according to Le Figaro, has not had access to the notes of the French secret services.
Asked for an official reaction, the French Foreign and Defense Ministries have declined to make any comment, and the French government spokesperson, Najat Vallaut-Belkacem, said she had "no confirmation of Le Figaro's information."


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Dompan OD Tablet 10'S
By Medley Pharmaceuticals Pvt Ltd Prescription Needed
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Please note, before you can choose the low cost generic option, please ask your doctor to add the generic drug to your prescription.
What is DOMPAN OD?
- DOMPAN OD contains domperidone and pantoprazole
- Domperidone belongs to a group of medicines called 'dopamine antagonists'
- Pantoprazole is a selective "proton pump inhibitor", a medicine which reduces the amount of acid produced in your stomach
What DOMPAN OD is used for?
It is used:
- for Reflux oesophagitis, an inflammation of your oesophagus accompanied by the regurgitation of stomach acid
- to treat infection with a bacterium called Helicobacter pylori in patients with duodenal ulcers and stomach ulcers in combination with two antibiotics (eradication therapy)
- to treat Zollinger-Ellison-Syndrome and other conditions producing too much acid in the stomach
- to treat nausea and vomiting
Talk to your doctor before taking this medicine, if you:
- are allergic (hypersensitive) to domperidone, pantoprazole or any of the other ingredients of this medicine
- are allergic to medicines containing other proton pump inhibitors
- have black, tarry bowel motions (stools) or notice blood in your bowel motions.
- have a blockage or tear in your intestines
- have a tumor of the pituitary gland called a prolactinoma
- have a moderate or severe liver and kidney disease
- have a heart problem called "prolonged QT corrected interval"
- have or had heart failure
- have a problem that gives you a low level of potassium or magnesium, or a high level of potassium in your blood
- are due to have a specific blood test (Chromogranin A)
- suffer from unintentional loss of weight
- If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine
- DOMPAN OD is not recommended for use in children as it has not been proven to work in children below 12 years of age
Talk to your doctor if you are taking medicines such as,
- oral ketoconazole, fluconazole or voriconazole used for fungal infections
- erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine used for bacterial infections
- heart problems or high blood pressure (e.g., amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol, diltiazem, verapamil)
- haloperidol, pimozide, sertindole used for psychoses
- citalopram, escitalopram used for depression
- gastro-intestinal disorders (e.g., cisapride, dolasetron, prucalopride)
- mequitazine, mizolastine used for allergy
- halofantrine used for malaria
- protease inhibitors used for AIDS/HIV
- toremifene, vandetanib, vincamine, erlotinib used for cancer
- apomorphine
- warfarin and phenprocoumon, which affect the thickening, or thinning of the blood
- methotrexate (used to treat rheumatoid arthritis, psoriasis, and cancer)
- fluvoxamine (used to treat depression and other psychiatric diseases)
- rifampicin (used to treat infections)
- St John's wort (Hypericum perforatum) (used to treat mild depression)
- Always take this medicine exactly as your doctor has told you
- For oral use only
- It must be swallowed with a glass of water
- Take this medicine 30 minutes before meals
If you take more DOMPAN OD
- If you or someone else have used or taken too much DOMPAN OD, contact your doctor or nearest hospital casualty department immediately
If you forget to take DOMPAN OD
- If you miss a dose, take your medicine as soon as you remember. If it is almost time for your next dose, wait until that is due and continue as usual. Do not take a double dose to make up for a forgotten dose
If you stop taking DOMPAN OD
- Do not stop taking DOMPAN OD without first talking to your doctor
Like all medicines, the medicine can have side effects, although not everybody gets them.
- swelling of the hands, feet, ankles, face, lips or throat
- difficulty in swallowing or breathing
- uncontrolled movements - irregular eye movements, unusual movements of the tongue, and abnormal posture such as a twisted neck, trembling and muscle stiffness
- very fast or unusual heartbeat
- swelling of the hands, feet, ankles, face, lips or throat which may cause difficulty in swallowing or breathing
- anxiety
- loss of interest in sex
- sleepiness or headache, diarrhoea
- rash or itchiness
- painful or tender breasts, or discharge from breasts
- a general feeling of weakness
- headache, dizziness
- feeling sick, vomiting bloating and flatulence (wind)
- constipation
- abdominal pain and discomfort
- skin rash, exanthema, eruption
- itching, feeling weak, exhausted or generally unwell
- sleep disorders
- fracture in the hip, wrist or spine
- increase in liver enzymes
- distortion or complete lack of the sense of taste
- disturbances in vision such as blurred vision
- hives, weight changes
- pain in the joints or muscle
- raised body temperature- sharp drop in circulating granular white blood cells
- swelling of the extremities (peripheral oedema)
- allergic reactions, depression
- breast enlargement in males
- increase in bilirubin, increased fat levels in blood
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.


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Actress Bobbi Jordan Dies at 75
She had a stint on "General Hospital" in the 1970s and appeared in the Lucille Ball musical "Mame."
Bobbi Jordan, who starred on General Hospital, in several primetime series and in the Lucille Ball film musical Mame, died Nov. 9 of a heart attack at her home in Encinitas, Calif. She was 75.
In the mid-1970s, Jordan had a three-year stint as former nightclub owner and singer Terri Webber Arnett on General Hospital. In one memorable story arc on the ABC daytime soap, she crashed her car after the wife of the man she was dating -- just released from a sanitarium -- tampered with her brakes. (Of course, he would operate on her to save her life.)
Later in the decade, Jordan had regular roles on the primetime comedies Turnabout, written by Steven Bochco and starring John Schuck and Sharon Gless, and Joe and Sons, with Richard S. Castellano and Jerry Stiller.
She also guest-starred on such series as The Man From U.N.C.L.E., The Wild Wild West, Love, American Style, Ironside, Barbary Coast, The Odd Couple, Charlie's Angels, Diff'rent Strokes, One Day at a Time, Quincy M.E., Nero Wolfe and Highway to Heaven.
In Mame, the 1974 musical directed by Gene Saks that was based on the Broadway hit, Jordan played Pegeen, a maid at the home of Mame Dennis (Ball) who winds up marrying Mame's nephew Patrick (Bruce Davison).
She also had a small role as a waitress in the Walter Matthau-starring A Guide for the Married Man (1967).
Jordan, born Roberta Carol Bartlett, moved from her hometown of Hardinsburg, Ky., to Chicago, then settled in Los Angeles to study opera. While working as a cocktail waitress, her manager at the club heard her singing in the kitchen and offered her a chance to audition for a musical the place was producing.
Jordan was cast as the lead in a modern-day telling of the Cinderella story and signed by William Morris. She then landed a role on The Rounders, an ABC Western that debuted in 1966.
Throughout her career, Jordan continued to sing and perform on stages around the country, with a lead role in the first national tour of Stephen Sondheim's musical Company and regional productions of Guys and Dolls, Damn Yankees, South Pacific and others.
Jordan's husband, Bill Jacobson, head writer for The Kate Smith Hour, died last year.
She is survived by her son, writer-director Jordan Roberts (March of the Penguins); her grandchildren, Brandon Roberts, a rock musician and songwriter; Cameron Roberts, a high school sophomore and aspiring actor; her sister, Reba Sue Waters; and her stepdaughter, Jessie Jacobson.
A memorial service is set for 3 p.m. Dec. 9 at the Self-Realization Fellowship Temple, 939 Second St., Encinitas, CA 92024.
JORDAN, Bobbie (Roberta Carol Bartlett)
Born: 7/11/1937 Hardensburg, Kentucky, U.S.A.
Died: 11/9/2012, Encinitas, California U.S.A.
Bobbie Jordan's westerns – actress:
The Rounders (TV) – 1966 (Ada)
The Wild Wild West (TV) – 1968 (Fleur Fogarty)
Barbary Coast (TV) – 1975 (Flame)


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Welcome to Paveco Driveways Westhoughton - 01204 775839
Paveco Driveways are a family owned building company covering Westhoughton that has over fifty years combined experience in the construction industry. Working in all areas of Westhoughton, Lancashire, Greater Manchester and Cheshire we specialise in driveways, block paving, patios & garden paving.
We are independent driveway installers in Westhoughton and approach many manufactures and suppliers to deliver the best possible quality and value for you. From low cost block paving to bespoke driveways in Westhoughton we'll find the right products to meet your budget and requirements.
Call us on 01204 775839 or request a free quotation online.
Our Driveway Paving & Garden Services Include:-
Driveways in Westhoughton
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Affordable garden wall builders, we build garden walls in Westhoughton to suit any garden lanscaping project.
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- subgroup problem (2) (remove)
Rewriting techniques have been applied successfully to various areas of symbolic computation. Here we consider the notion of prefix-rewriting and give a survey on its applications to the subgroup problem in combinatorial group theory. We will see that for certain classes of finitely presented groups finitely generated subgroups can be described through convergent prefix-rewriting systems, which can be obtained from a presentation of the group considered and a set of generators for the subgroup through a specialized Knuth-Bendix style completion procedure. In many instances a finite presentation for the subgroup considered can be constructed from such a convergent prefix-rewriting system, thus solving the subgroup presentation problem. Finally we will see that the classical procedures for computing Nielsen reduced sets of generators for a finitely generated subgroup of a free group and the Todd-Coxeter coset enumeration can be interpreted as particular instances of prefix-completion. Further, both procedures are closely related to the computation of prefix Gr"obner bases for right ideals in free group rings.
Todd and Coxeter's method for enumerating cosets of finitely generated subgroups in finitely presented groups (abbreviated by Tc here) is one famous method from combinatorial group theory for studying the subgroup problem. Since prefix string rewriting is also an appropriate method to study this problem, prefix string rewriting methods have been compared to Tc. We recall and compare two of them briefly, one by Kuhn and Madlener [4] and one by Sims [15]. A new approach using prefix string rewriting in free groups is derived from the algebraic method presented by Reinert, Mora and Madlener in [14] which directly emulates Tc. It is extended to free monoids and an algebraic characterization for the "cosets" enumerated in this setting is provided.


text:
sponsored by
IRS chief says no delay in tax-dodger law; some have doubts
Send a link to a friend
[February 01, 2014]
By Patrick Temple-West
WASHINGTON (Reuters) — The chief of the
U.S. Internal Revenue Service said on Friday that a new law meant to
fight offshore tax dodging by Americans will not be delayed again beyond
its July 1 effective date, despite a clamor among banks asking for more
time and guidance.
"We're not going to have any delays," IRS Commissioner John
Koskinen told reporters on a conference call.
His remarks came five months before the United States must start
enforcing the Foreign Account Tax Compliance Act (FATCA). It will
require foreign banks, insurers and investment funds to send the IRS
information about Americans' offshore accounts worth more than
Foreign businesses that do not comply with the law can be
effectively frozen out of U.S. capital markets because of a
30-percent withholding tax on U.S. source income.
The IRS is expected soon to publish forms and guidance that
financial institutions are keenly awaiting so they can figure out
how to avoid FATCA penalties.
"We expect to issue the final package of rules shortly," a Treasury
spokeswoman said on Friday.
"We are working diligently to finalize all related guidance to
ensure that financial institutions have time to effectively prepare
and comply, and there is no consideration for a delay of FATCA
implementation," the spokeswoman said.
Jonathan Jackel, a lawyer with Burt, Staples & Maner LLP, said the
more time Treasury takes to publish the final guidance, the likelier
it is that the law could be delayed again.
"They can't possibly expect people to comply with rules that have
not been published yet," he said.
"If there is going to be a delay, it will be more of an internal
issue within the government — whether they can crank out the
infrastructure that they need," he said.
[to top of second column]
The lack of FATCA guidance from the government prompted four bank
lobbying groups in November to ask the Obama administration for
another six-month delay in a law that has already been delayed
Signed into law by President Barack Obama in 2010, the law was
originally supposed to take effect on January 1, 2013.
In 2011, the start-date was postponed to January 1, 2014. Then in
the middle of last year, the start-date was pushed back again to
July 1, 2014.
There is room within the law to spare financial institutions the
FATCA withholding after July 1, former Treasury Department officials
"They can certainty provide relief. There has always been
flexibility on certain aspects of this," said John Harrington, a
former Treasury official who is now with law firm Dentons LLP.
But given strong assurances from the Obama administration that the
law will not be delayed again, "it would take something
extraordinary" for the administration to waiver, he said.
A source familiar with the Obama administration's position on FATCA
said the White House will not allow another delay.
(Editing by Kevin Drawbaugh and Ken Wills)
[© 2014 Thomson Reuters. All rights
Copyright 2014 Reuters. All rights reserved. This material may not be published,
broadcast, rewritten or redistributed.
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Washington, D.C. -- The Animal Welfare Institute is pleased to report that Reps. Mike Doyle (D-PA) and Chris Smith (R-NJ) - in an effort to protect companion animals from illegal use in laboratory experiments - today reintroduced, H.R. 2256, the Pet Safety and Protection Act. This bill would prohibit notoriously shady Class B dealers from selling dogs and cats to researchers.
By law, Class B dealers are supposed to acquire the animals they sell only from other dealers, pounds, and individuals who have bred and raised the animals themselves. However, these dealers and their suppliers (called "bunchers") routinely flout the Animal Welfare Act, obtain animals through fraud, deception, and outright theft, and falsify their records. They keep the animals in horrendous conditions. The U.S. Department of Agriculture spends hundreds of thousands of taxpayer dollars each year unsuccessfully trying to regulate them and has acknowledged that it can't guarantee that dogs and cats are not being illegally acquired for use in experimental procedures. Five of the eight dealers currently in operation are under investigation by the USDA, with one of them having recently been indicted on a number of federal charges, including identity theft. Another one who has been under investigation turned in his license though the case against him is still pending, and a third is halfway through a five-year suspension.
"Class B dealers have racked up an atrocious record of illegal activity and cruelty to animals," Congressman Doyle said today in reintroducing the bill. "Allowing this failed program to continue is simply unacceptable. That's why we're re-introducing the Pet Safety and Protection Act -- to shut down the Class B dealer disaster once and for all."
In May 2009, the National Academy of Sciences released a report entitled "Scientific and Humane Issues in the Use of Random Source Dogs and Cats in Research." At the request of Congress, NAS assessed whether there is a scientific need for NIH grant recipients to purchase dogs and cats from B dealers. It found that animals with similar qualities are available from alternative sources. The report stated: "The Committee therefore determined Class B dealers are not necessary as providers of random source animals for NIH-related research." In response to this report and continued Congressional concern, NIH is now phasing out the use of these dealers by its grant recipients.
The Pet Safety and Protection Act is essential to ensuring that there is a permanent end to this abuse-ridden pipeline. "Class B dealers have routinely failed to meet basic Animal Welfare Act Standards and there is no sign they will ever improve," remarked Congressman Smith. "Reputable research institutes do not use Class B dealers because of the serious problems associated with them and their troubled past. Closing them down once and for all will give people greater confidence in our research programs and go a long way toward reducing animal cruelty."
Animal Welfare Institute President Cathy Liss welcomed the bill's reintroduction: "Most researchers do not use Class B dealers to acquire dogs and cats, and it is time for the remainder who do to end their embarrassing association with these habitual violators of the law."
Media Contacts:
Cathy Liss, (202) 446-2121
Nancy Blaney, (202) 446-2141


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For french class, we've been given an assignment where we have to write an argumentative text in the form of a letter to some company as a complaint. The problem is there aren't any companies that I have any complaints against. I originally searched for some that purposely inhibits Linux or some of its features but found none.
Any1 know of a company I can bash for the purpose of this assignment?


text: My bosses wife sent me two panels - one Super Man and the other Army. Each had 4 picture squares, and she wanted to make a quilt to put in her nephews dash board to protect the car. I told her you did not put quilts on the dash board, the sun would rot them, and fade them out. She wanted to know what I would do with the panels. Hummmm Super Man and Army. How did one go about this. I ended up making a two sided quilt. I was thrilled with the outcome, and I think the recipient was too. He leaves for the Army in August - he chose the intelligence field, and I could not be happier for him. Take a look.


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In a chemical peel, a chemical solution is applied to the skin and allowed to soak in. Over the next 1 to 14 days, depending on how deeply the chemical penetrated the skin, the skin peels off. This procedure destroys parts of the skin in a controlled way so that new skin can grow in its place. The chemicals used are sometimes called exfoliating or wounding agents.
The types of chemical peels differ based on how deeply the chemical penetrates and what type of chemical solution is used. Factors that may affect the depth of a peel include the acid concentration in the peeling agent, the number of coats that are applied, and the amount of time allowed before the acid is neutralized. Deeper peels result in more dramatic effects as well as higher risks, increased pain, and longer healing time. There are three basic types of peels:
Your doctor can help you decide what depth of peel and what type of chemical solution is most appropriate, based on your skin type, which areas you want peeled, what kind of results you want, how much risk you are willing to take, and other issues. A small "test spot" may be peeled to get a better idea of the results, especially for people with darker skin.
Two to three weeks before the peel, you will need to begin preparing your skin by cleansing it twice a day, applying a special moisturizer or cream once or twice a day, and using sunscreen every day. In some cases, daily use of tretinoin (Retin-A), a topical medicine usually used to treat acne, is also recommended and may speed healing. This skin care regimen will help the skin peel more evenly, speed healing after the peel, and may reduce the chance of infection and other complications, especially uneven color changes in the skin.
For medium and deep peels of the face, you may be given a short course of medicine (such as acyclovir) to prevent viral infection. This is especially likely if you have had cold sores before, and the peel will be in the areas near the mouth or eyes.
Right before the peel, the skin is cleaned. The chemical (usually a liquid or paste) is then applied to the skin with a small brush, gauze, or cotton-tipped applicators. The chemical is left on the skin for several minutes, depending on the type of chemical used. Water or alcohol may be used to neutralize the acid and end the chemical reaction, then it is wiped off. You may feel a little burning while the chemical is on your skin. A handheld fan can help cool the skin and relieve any discomfort.
The technique used to do a medium peel is similar to that used for a superficial peel, but the chemical may be left on for a longer period of time. Medium peels are more painful than superficial peels, because the chemicals are stronger and they soak deeper into the skin. You may be given a pain reliever and an oral sedative to reduce pain and anxiety during the procedure. Cool compresses and fans can be used to cool the stinging and burning caused by the chemical. The procedure takes about 40 minutes. There is little or no pain after the peel is finished.
Deep peels take the most time and are the most painful type of chemical peel. The procedure for a deep peel using phenol is also more complicated than for other types of peels.
Depending on how large an area is being treated, the entire procedure may take 60 to 90 minutes.
Recovery time after a chemical peel depends on what kind of peel was done and how deep it was. With all types of peels, proper care of the skin after the peel is very important to speed healing, help results last longer, prevent infection, and avoid color changes in the treated area caused by sun exposure. Proper skin care after a peel is very similar to the care used to prepare for a peel and typically involves:
Some doctors may also recommend using tretinoin cream nightly, usually starting 2 to 3 weeks after the peel.
Superficial peels are done on an outpatient basis, do not require anesthesia, and cause only slight discomfort afterwards. Most people can return to their normal activities immediately. The skin heals quickly after a superficial peel. The skin may turn pink, and usually only minimal peeling occurs. You can use makeup to hide any redness until it fades.
Medium peels are usually done on an outpatient basis, but you may need to take a few days off work to recover. A medium peel causes a second-degree burn of the skin. The skin takes 5 to 7 days to heal to a point where you can use makeup to hide the redness caused by the peel. There is little or no pain after the peel, but there may be some swelling, especially if the area around the eyes is treated. The skin will turn reddish brown in 2 to 3 days, become crusty, and then flake and peel over the next few days.
A deep peel causes a deeper second-degree burn of the skin. Skin regrowth takes between 10 to 14 days after a deep peel. The skin remains extremely red for 3 weeks, up to 2 months for some people. Most people take about 2 weeks off from work. Complete healing of the skin may take several months.
Chemical peels are sometimes done with dermabrasion or laser resurfacing for a more dramatic overall effect.
A chemical peel (except for a superficial peel) may not be done if you have:
The results of a chemical peel depend in part on the depth of the peel.1
Your skin type, skin care before and after the peel, the doctor's level of experience, and your lifestyle after the procedure can also affect the results. Some types of skin problems respond better to chemical peeling than others. People with lighter skin who limit their sun exposure after the procedure tend to have better results than those with darker skin and those who continue to spend lots of time in the sun.
Before you decide to have a chemical peel, talk to your doctor about the kind of results you can expect.
Changes in the color and texture of the skin caused by aging and sun exposure may continue to develop after a chemical peel. Chemical peels are not a permanent solution for these problems.
In general, the deeper the peel, the greater the risk of side effects and complications.1 Chemical peels can result in:
Deep peels using phenol can rarely cause more severe complications during the procedure, including heart,liver, or kidney failure.
Chemical peels are designed to wound and remove the upper layers of the skin. You need to prepare yourself for how your skin will look immediately after the peel and throughout the healing process. You also need to be prepared to use cosmetics to blend skin tones between treated and untreated areas, such as between the face and jawline.
It is important that your doctor understand what you hope to achieve and that you understand what results you can realistically expect. Even with realistic expectations, you may not see results for several weeks or months after a chemical peel.
During the early healing period after a chemical peel (before the skin has finished peeling), you will need to avoid sun exposure. After the early healing period has passed, you will need to wear sunscreen every day and limit sun exposure as much as possible. New skin is more susceptible to damage and discoloration from sunlight.
Chemical peel, dermabrasion, and laser resurfacing are the most commonly used techniques for improving the texture and appearance of the skin. Although these techniques use different methods, they have basically the same effect on the skin-they destroy and remove the upper layers of skin to allow for skin regrowth.
No one technique is necessarily better than the others. When done by an experienced surgeon, laser resurfacing may be slightly more precise than chemical peeling or dermabrasion. But the choice of technique is based on the site you want to treat, your skin type and condition, the doctor's experience, your preferences, and other factors. Some people may get the best results using a combination of techniques.
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