text:
le Roux, J. H., Departement Ou Testament (Afd B) Universiteit van Pretoria, South Africa
Vol 52, No 4 (1996) - Original Research
Andries van Aarde se Matteusinterpretasie
Abstract PDF
Our offices will close for the RSA Holiday Season on the 19th of December 2019 and will reopen on the 6th of January 2020. We want to express our sincerest appreciation for the trust you have placed in us. Best wishes for the holidays.
Reformed Theological College of the Netherdutch Reformed Church of Africa, at the Faculty of Theology of the University of Pretoria
Society for Practical Theology in South Africa
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HTS Teologiese Studies / Theological Studies | ISSN: 0259-9422 (PRINT) | ISSN: 2072-8050 (ONLINE)


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The evolutionary history of modern humans could be in for a bumpy ride following revelations that a German anthropologist, Professor Reiner Protsch von Zieten, falsified dates of human remains.
It seems these days that there are precious few ordinary human or ape fossils unearthed, rather they all have to be a missing link between the two.
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Answers in Genesis is an apologetics ministry, dedicated to helping Christians defend their faith and proclaim the gospel of Jesus Christ.

subset: commoncrawl


text:
54" Heavy-Duty Professional Cutter
Graphtec is proud of its reputation as a proven global leader in imaging products for the sign industry, garment and apparel industry, reprographics, design and packaging industries. With Graphtec, you can depend on superior performance, reliability, precision and quality production output.
Graphtec cutting plotters are designed to meet the demanding requirements of design professionals in packaging design, vinyl sign graphics, garment and apparel, automotive aftermarket styling, automotive protection, monument builders and manufacturing design related industries. Our diverse line of roll-feed and flatbed cutting plotters can accommodate any size project, large or small.
The Graphtec FC8600-130 54" Cutter; Has a 3 inch wide user-friendly LCD control Panel, a Dual configuration function (two-user set and save customized conditions), included Ethernet capability (run multiple machines from one location), additional push rollers with 3 tension settings and the new 5th Generation ARMS system (automatically detects registration marks with color variants) with improved sensitivity adjustment for registration mark detection on various media and colors.
Features a maximum cutting speed of 58.5 in/sec, 4.0G maximum acceleration, and 20 to 600g selectable cutting forces, allowing users to process diamond grade, high-intensity reflective film, sandblast resist rubber, automotive window & paint protection films, self-adhesive vinyl, Amberlith™ and Rubylith™, among other media types. Each unit includes standard media roll rack, floor stand and dual media catch basket for dust-free, continuous long length and/or repetitive job operations Also includes Cutting Master 3 with plug-in for Adobe Ullustrator and Corel Draw, and Graphtec's Studio design software.
Graphtec America's List Price $5,995.00
Call us for the price we really sell it for!
|54" Heavy-Duty Professional Cutter
|Brand: Graphtec


text: This is a brief list of research projects where fabrication was performed in the Nanofabrication Facility at UC Santa Barbara. The following projects will provide you with samples of the capabilities at our research facility. Some of the research summaries have links to further research for more in depth or related information.


text:
Ruth Ozeki is a novelist, filmmaker, and Zen Buddhist priest.
Her first two novels, My Year of Meats (1998) and All Over Creation (2003), have been translated into 11 languages and published in 14 countries. Her most recent work, A Tale for the Time-Being (2013), was shortlisted for the Man Booker Prize and will be published in over thirty countries. Ruth's documentary and dramatic independent films, including Halving the Bones, have been shown on PBS, at the Sundance Film Festival, and at colleges and universities across the country.
A longtime Buddhist practitioner, Ruth ordained in 2010 and is affiliated with the Brooklyn Zen Center and the Everyday Zen Foundation. She lives in British Columbia and New York City.
"An exquisite novel: funny, tragic, hard-edged and ethereal at once." — David Ulin, Los Angeles Times
"Ozeki takes on big themes . . . drawn into the stories of two 'time beings,' Ruth and Nao, whose own fates are inextricably bound." — The New York Times Book Review
"Ozeki's profound affection for her characters makes A Tale for the Time Being as emotionally engaging as it is intellectually provocative." — The Washington Post
"As Ozeki explores the ties between reader and writer, she offers a lesson in redemption that reinforces the pricelessness of the here and now." — Elle


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Selling your home can be a lengthy and emotional process. If you're buying a new home at the same time, you can easily feel overwhelmed. Trying to do two things at once is never easy. Here are some tips to help you keep things in balance.


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With the S.S. Katherine Heigl taking on water at a terrifying pace, the actress has reached out for a lead life jacket.
Heigl will star in "Face Blind," as a shrink with a rare condition that renders her unable to recognize people, and finds herself the target of a stalker that she of course can't recognize, reported Deadline. The actress will also serve as producer, along with Trudie "Mrs. Sting" Styler and Celine Rattray of Maven Pictures.
If you're suffering from plot blindness, and can't quite place this one, Milla Jovovich starred in the 2011 thriller "Faces in the Crowd," as a woman with face blindness who escapes the clutches of a serial killer, but is helpless to recognize him when he comes back to finish the job. It opened Oct. 7 in Turkey, but never made it stateside.
Heigl's box office fortunes have been in a fairly steady decline since she achieved movie star status with "Knocked Up." Take a look at this handy chart of Heigl's B.O. in millions, starting with "Knocked Up" and going through to the opening weekend of "One for the Money," a film whose receipts were boosted by a Groupon deal:
It's not a pretty picture, is it? And that second up-tick doesn't really count, cuz "New Year's Eve" wasn't a "Katherine Heigl movie." Ever since Shonda Rhimes and Judd Apatow helped make her hugely famous, her career's been in free fall--maybe she should reconsider all the nasty things she said about them.


text:
Twins add eight players to Major League roster
Agree to terms with 12 others on minor league contracts
Minneapolis/St. Paul, MN – The Minnesota Twins announced today that they have added outfielder Aaron Hicks, infielder Danny Santana, catcher Josmil Pinto, left-handed pitcher Caleb Thielbar and right-handed pitchers Kyle Gibson, B.J. Hermsen, Michael Tonkin and Tim Wood to their major league roster.
Hicks batted .286 (135-for-472) with 21 doubles, 11 triples, 13 home runs, 61 RBI and 100 runs scored in 129 games at Double-A New Britain. Hicks, who was named to the Baseball America Double-A All-Star Team, was drafted by the Twins in the first round (14th overall) of the 2008 First-Year Player Draft out of Woodrow Wilson (CA) High School.
Santana batted .286 (145-for-507) with 21 doubles, nine triples, eight home runs, 60 RBI and 70 runs scored in 121 games at Single-A Ft. Myers. Santana was signed by the Twins as a non-drafted free agent in December of 2007 at the age of 17 and is a native of the Dominican Republic.
Pinto hit a combined .295 (117-for-396) with 14 home runs and 60 RBI in 105 games between Ft. Myers and New Britain. Pinto, who was selected to the Florida State League All-Star Game and later named as the High Class-A All-Star Catcher by Baseball America, was signed by the Twins as a non-drafted free agent in 2006 and is a native of Venezuela.
Thielbar pitched at three different levels for the Twins last season, including Ft. Myers and New Britain before finishing the season with Triple-A Rochester. Over a combined 48 appearances, Thielbar posted a 2.43 ERA (77.2 IP, 21 ER) with 74 strikeouts and just 21 walks. The Randolph, Minnesota native attended South Dakota State University and was signed by the Twins as a minor league free agent in 2011.
Gibson spent the season rehabbing from "Tommy John" surgery and made a combined 13 minor league appearances, including two starts for Rochester. Gibson, who was originally drafted by the Twins in the first round of the 2009 First-Year Player Draft (22nd overall) out of the University of Missouri, recently made six starts for the Peoria Javelinas in the Arizona Fall League and posted a 3-2 record with a 5.40 ERA (23.1 IP, 14 ER).
Hermsen started the season at Ft. Myers before being promoted to New Britain on April 30. The Iowa native made 22 starts for the Rock Cats and posted a 3.22 ERA (139.2 IP, 50 ER) while earning an Eastern League All-Star selection. Hermsen, who was named the Twins Minor League Pitcher of the Year, was drafted by the Twins in the sixth round of the 2008 First-Year Player Draft out of West Delaware (IA) High School.
Tonkin made a combined 44 appearances between Single-A Beloit and Ft. Myers and went 4-1 with a 2.08 ERA (69.1 IP, 16 ER) with 12 saves and 97 strikeouts. Tonkin, who was named the Twins Minor League Pitcher of the Month in June, was originally drafted by the Twins in the 30th round of the 2008 First-Year Player Draft out of Palmdale (CA) High School.
Wood posted a 2.19 ERA (70.0 IP, 17 ER) over 54 appearances for Triple-A Indianapolis (Pittsburgh) last season. Signed by the Twins as a minor league free agent earlier this month, Wood was named the International League Relief Pitcher of the Year by Baseball America. The 30-year old has made 57 major league appearances with Florida and Pittsburgh and is a native of Tucson, Arizona.
In addition, the Twins have agreed to terms with the following players on minor league contracts with invitations to major league camp: right-handed pitchers Samuel Deduno, Shairon Martis, Luis Perdomo, Esmerling Vasquez and P.J. Walters; outfielders Brian Dinkleman and Wilkin Ramirez; infielders James Beresford and Deibinson Romero and catcher Eric Fryer.
Lastly, the Twins agreed to minor league contracts with right-handed pitcher Tom Boleska and infielder Jason Christian and they will report to minor league camp.
The Twins now have 40 players on their major league roster.


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Swimming Pool Blog
by Rob Cox, October 24, 2012
Sunbelt Pool Winterization
Ask most sunbelt pool owners about pool winterization, and they look at you kind of funny. For most sunbelters, it's rare that the pool freezes over, like in the picture, because most sunbelt pools are kept circulating, with only occasional dips below 32 degrees.
As the weather turns cool, the average sunbelt pool is used very little, maybe not at all. Even so, the southern pool owner has to continue operating the pool pump, keep the water balanced and clean. There are times - below freezing temps, where the pump must be running to prevent freeze damage.
If you'd rather not worry about the pool this winter, and save 4-5 months of pump electricity and chemical expense - you can do a partial pool winterization. For many of those in the white portions of the map, a partial pool closing can be preferable to maintaining an unused pool all year around.
1. Balance your water chemistry
You know - pH, Alkalinity and Calcium Hardness levels. Use a quality test kit and adjust to correct levels. After balancing, shock the pool with either chlorine or non-chlorine based pool shock.
2. Vacuum, Brush and Skim your pool
In that order. Even if your pool cleaner keeps your pool very clean, a good brushing of the pool surfaces, with a good pool brush is important before shutting down for the winter.
3. Lower the water level below the skimmer
If you have a separate main drain, close the skimmers and continue backwashing or draining water to 1-2" below the skimmer opening for a solid cover, or 6-8" for a mesh cover. You can usually "suck the skimmers dry", after the water level has dropped below the opening to the skimmer. Do this by opening the skimmer valve slowly, while it's running full steam on the main drain only. You may be able to hear the skimmer sucking air, just before the air gets sucked into the pump. Just as the air from the skimmer line reaches the pump, close the valve quickly, to resume pumping from the main drain only. Using this method, you will remove most of the water from the skimmer.
4. Cover the Pool
Options for covering the pool include safety pool covers, solid pool covers and leaf nets. Safety pool covers can be either mesh or solid, and are made to fit the exact shape of your pool (plus one foot all around). These covers anchor into the deck for safety, they look great, and can last over 12 years. Solid covers are laminated polypropylene tarps that float on the water, and are held in place with water bags placed around the edge. A small cover pump, attached to a garden hose, is needed to pump off rain water.
Leaf nets are not really meant to be used as a winter cover, but would be better than having none at all. Leaf nets will block some of the sun, but not nearly as much as a solid cover or a safety cover.
Blocking the sun is a big part of what winter pool covers do, in addition to keeping debris and dust out of the pool. This will help to ensure that your unfiltered water will stay fresh and clean. Without a winter cover, most stagnant pools will grow algae when water temps are above 60 degrees.
5. Drain the Equipment
If your pool equipment is below the level of the pool water, draining the equipment is difficult, and different steps would be involved. But, assuming that your pump and filter is at or above water level, you can simply remove the drain plugs on all your pumping, filtering, heating and sanitizing equipment. Move all of your valves, including the backwash valve, to make sure no water is left standing inside or up against a closed valve.
What about the underground plumbing lines? For most sunbelt pools, these need not be drained or blown out, as they are for snowbelt pools. For the water to freeze in underground pipes, a freeze of 1-2 weeks duration is usually necessary. If you want to add some insurance, you can pour some pool antifreeze into the skimmer lines, and use a hose to pour some into your return lines. An extra step for skimmers is to plug the lines with winter plugs.
And that's how you can winterize a sunbelt pool. It's everything a northern pool would do, with the exception of blowing out the lines. The benefits to this type of partial winterization for sunbelt pool owners are:
- Reduce pool maintenance for 4-6 months.
- Reduce wear and tear on your pool equipment.
- Reduce electrical and chemical consumption.
- Increase pool safety, when a safety cover is used.


text:
> Near surface disposal of short-lived low- and intermediate-level waste
> Safe disposal of high-level waste in deep clay layers
> Reducing radioactive waste and making it less radiotoxic: transmutation
Mankind produces radioactive waste in many nuclear applications. We are all familiar with the production of electricity in nuclear power plants. However, hospitals and industry also produce radioactive waste.This waste continues to emit ionising radiation for decades, hundreds or even thousands of years. In order to protect humans and the environment from the potentially damaging effects of this radiation, SCK•CEN is searching for long-term management solutions for this waste.
SCK•CEN is collaborating closely with ONDRAF/NIRAS, the national institute for radioactive waste and enriched fissile materials, which is responsible for the short- and long-term management of all radioactive waste produced in Belgium.
Each type of radioactive waste demands a specific solution. In Belgium, short-lived low- and intermediate-level waste will be stored near the surface in a specially designed installation. We are investigating whether it would be feasible and safe to bury high-level and long-lived waste deep underground.
© 2019, SCK•CEN | Website design by Pixeo


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Reward Points
Reward Points are the bonus that you receive in your account for buying products in the store. Each purchase you make earns Reward Points that you can spend like real money in our store.
You can choose to apply your points to your next eligible product purchase, or you can let your points accumulate.
Reward Points may be combined with any other discounts we may offer because they are not really a discount. Reward Points are a reward from us, thanking you for choosing to make your magic purchases at Rings N Things.
Your Reward Points will be updated with points earned from new purchases the moment that your order ships.
Earning Points
When products you purchase indicate a value in Reward Points, this represents how many points you earn from purchasing the product.
Your Reward Points earned are stored and reported in your Account.
Once you have signed into your account, you will see a link for My Points in the My Account menu. This link reports how many points you have available in your account. Clicking on this link will take you to the Reward Points Log. This log reports the points earned from each of your orders and the orders in which you redeemed your points.
Points won't appear for new purchases until your order has shipped.
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When products you purchase indicate a Price In Points, this represents how many points you can redeem towards purchasing the product.
Once you have added a product to your shopping cart that can be purchased with points, and signed into your account, you will see a link for Point Payment in the shopping cart and on the checkout page. Clicking on this link will expand or compress the form for applying your points to your purchase. Click on the link to expand the form and it reports how many points you have available in your account and gives you an input field where you can enter a number of points to redeem.
Enter the number of points you would like to redeem.
Click the "APPLY" BUTTON and your order total is recalculated.
The number of points in your account will not change until you have completed checkout.
To view your redemption history, click the My points link in the My Account menu after signing in. The Reward Points log will report the orders that earned points and the orders in which you redeemed the points.
Remember, points won't appear for new purchases until your order has shipped.
Rings -N- Things wants your purchase to be worry-free.
The products we offer are in stock and available to ship immediately and we promise to ship your order the next business day whenever possible. Some of our products are bare metal and require their finish to be touched up prior to shipping. Those products many take one additional day to ship. In the rare instance that your order has not been delivered within 30 days of shipment, we will consider the order lost and replace the lost shipment as quickly as possible.
If you believe your shipment to be lost, write to us here (please include your Order ID): Contact Us
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Rings -N- Things will ship to all US states and territories. If you can select your state from the list when you are setting up your account's shipping address then we ship there.
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- USPS Priority and USPS Express both include Tracking. When you purchase USPS Priority or USPS Express, you will receive a copy of the USPS Tracking number which you can use at USPS.com to track your order.
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Rings -N- Things will ship to most international locations. If you can select your country from the list when you are setting up your account's shipping address then we ship there.
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If for any reason you are not satisfied you can return any item, without custom monogramming and in its original condition, within 30 days of the date of shipment for a credit, refund or replacement. It's that simple.
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Our return policy does not apply to products that can be copied, read, learned or consumed. Unless a product is defective, the non-returnable items include:
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If you receive a damaged or defective item, you may request a Return Authorization immediately. Rings-N-Things will make every reasonable effort to assist you with your return.
Read our Return Instructions to request a Return Authorization.
Mendoza Combo Cups | Copper | Mirror Finish
1 1/8" RNT Red Balls Included
The Mendoza Combo Cups are the finest combo cup set you may ever handle, the Mendoza Combo Cups are hand-spun from .050 gauge copper with a thick insert in each cup so all cups are of equal weight and balance, providing a satisfying weight and feel to each cup. The set is designed from the ground up as a combo set resulting in each cup looking and feeling identical, and rendering the gaff undetectable.
Each cup is hand spun from .050 copper and the exterior is polished to a glossy mirror finish. The interior is a brushed satin copper finish.
A lot of trial and error, prototypes and engineering went into these cups to make them the finest quality working combo set on the market today. Used and endorsed by John Mendoza as the official John Mendoza Copper Combo set, John had these kind words to say:
"I have spent the last four years looking for the perfect set of Combo cups for my Mendoza Cups & Balls routine. I have tried virtually every cup maker you can imagine, from the low end cheap cups to the very highest end silver cups and every maker in between, including some very nice attempts from RNT II. I have had no success. To my absolute delight, RNT II has now succeeded in making the perfect cups. Their feel and weight is perfect. All three cups have the same feel and weight. The release is as close to perfect as one can get and the size holds a big load without looking like a big cup. I honestly cannot recommend any cup more highly for the Mendoza Cups & Balls Routine." John Mendoza
Made in USA.
- 2 x Mendoza Cups
- 1 x Mendoza Chop Cup
- 4 x 1 1/8" RNT Red Balls
- 1 x 1 1/8" RNT Red Magnetic Ball
- Velvet Bag


text:
Summary: CBS domain
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CBS domain Edit Wikipedia article
|CBS domain
Structure of the yeast SNF4 protein that contains four CBS domains.[1] This protein is part of the AMP-activated protein kinase (AMPK) complex.
|1zfj / SUPFAM
In molecular biology, the CBS domain is a protein domain found in a range of proteins in all species from bacteria to humans. It was first identified as a conserved sequence region in 1997 and named after cystathionine beta synthase, one of the proteins it is found in.[2] CBS domains are also found in a wide variety of other proteins such as inosine monophosphate dehydrogenase,[3] voltage gated chloride channels[4][5][6][7][8] and AMP-activated protein kinase (AMPK).[9][10] CBS domains regulate the activity of associated enzymatic and transporter domains in response to binding molecules with adenosyl groups such as AMP and ATP, or s-adenosylmethionine.[11]
The CBS domain is composed of a beta-alpha-beta-beta-alpha secondary structure pattern that is folded into a globular tertiary structure that contains a three-stranded antiparallel β-sheet with two α-helices on one side. CBS domains are always found in pairs in protein sequences and each pair of these domains tightly associate in a pseudo dimeric arrangement through their β-sheets forming a so-called CBS-pair or Bateman domain.[12][13] These CBS domain pairs can associate in a head-to-head (i.e. PDB codes, 3KPC, 1PVM, 2OOX) or a head-to-tail (i.e. PDB codes 1O50, 1PBJ) manner forming a disk-like compact structure. By doing so, they form clefts that constitute the canonical ligand binding regions.[14][15][16][17][18] In principle, the number of canonical binding sites matches the number of CBS domains within the molecule and are traditionally numbered according to the CBS domain that contains each of the conserved aspartate residues that potentially interact with the ribose of the nucleotides.[19] However, not all of these cavities might necessarily bind nucleotides or be functional. Recently, a non-canonical site for AMP has also been described in protein MJ1225 from M. jannaschii, though its functional role is still unknown.[20]
Ligand binding
It has been shown that CBS domains bind to adenosyl groups in molecules such as AMP and ATP,[11] or s-adenosylmethionine,[21] but they may also bind metallic ions such as Mg2+.[22][23] Upon binding these different ligands the CBS domains regulate the activity of associated enzymatic domains.[24] The molecular mechanisms underlying this regulation are just starting to be elucidated.[16][17][21][22][25] At the moment, two different type of mechanisms have been proposed. The first one claims that the nucleotide portion of the ligand induces essentially no change in the protein structure, the electrostatic potential at the binding site being the most significant property of adenosine nucleotide binding.[17][26] This "static" response would be involved in processes in which regulation by energy charge would be advantageous.[17][26] On the contrary, the second type of mechanism (denoted as "dynamic") involves dramatic conformational changes in the protein structure upon ligand binding and has been reported for the cytosolic domain of the Mg2+ transporter MgtE from Thermus thermophilus,[22] the unknown function protein MJ0100 from M. jannaschii [21][27] and the regulatory region of Clostridium perfringens pyrophosphatase.[28]
Associated domains
CBS domains are often found in proteins that contain other domains. These domains are usually enzymatic, membrane transporters or DNA-binding domains. However, proteins that contain only CBS domains are also often found, particularly in prokaryotes. These standalone CBS domain proteins might form complexes upon binding to other proteins such as kinases to which they interact with and regulate.
Mutations leading to disease
Mutations in some human CBS domain-containing proteins leads to genetic diseases.[3] For example, mutations in the cystathionine-beta-synthase protein lead to an inherited disorder of the metabolism called homocystinuria (OMIM: 236200).[29] Mutations in the gamma subunit of the AMPK enzyme have been shown to lead to familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome (OMIM: 600858). Mutations in the CBS domains of the IMPDH enzyme lead to the eye condition retinitis pigmentosa (OMIM: 180105).
Humans have a number of voltage-gated chloride channel genes, and mutations in the CBS domains of several of these have been identified as the cause of genetic diseases. Mutations in CLCN1 lead to myotonia (OMIM: 160800),[30] mutations in CLCN2 can lead to idiopathic generalised epilepsy (OMIM: 600699), mutations in CLCN5 can lead to Dent's disease (OMIM: 300009), mutations in CLCN7 can lead to osteopetrosis (OMIM: 259700),[31] and mutations in CLCNKB can lead to Bartter syndrome (OMIM: 241200).
- ^ PDB: 2nye; Rudolph MJ, Amodeo GA, Iram SH, Hong SP, Pirino G, Carlson M, Tong L (January 2007). "Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding". Structure. 15 (1): 65–74. doi:10.1016/j.str.2006.11.014. PMID 17223533.
- ^ Bateman A (January 1997). "The structure of a domain common to archaebacteria and the homocystinuria disease protein". Trends Biochem. Sci. 22 (1): 12–3. doi:10.1016/S0968-0004(96)30046-7. PMID 9020585.
- ^ a b Ignoul S, Eggermont J (December 2005). "CBS domains: structure, function, and pathology in human proteins". Am. J. Physiol., Cell Physiol. 289 (6): C1369–78. doi:10.1152/ajpcell.00282.2005. PMID 16275737.
- ^ Ponting CP (March 1997). "CBS domains in CIC chloride channels implicated in myotonia and nephrolithiasis (kidney stones)". J. Mol. Med. 75 (3): 160–3. PMID 9106071.
- ^ Meyer S, Dutzler R (February 2006). "Crystal structure of the cytoplasmic domain of the chloride channel ClC-0". Structure. 14 (2): 299–307. doi:10.1016/j.str.2005.10.008. PMID 16472749.
- ^ Yusef YR, Zúñiga L, Catalán M, Niemeyer MI, Cid LP, Sepúlveda FV (April 2006). "Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain". J. Physiol. 572 (Pt 1): 173–81. doi:10.1113/jphysiol.2005.102392. PMC 1779660. PMID 16469788.
- ^ Markovic S, Dutzler R (June 2007). "The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface". Structure. 15 (6): 715–25. doi:10.1016/j.str.2007.04.013. PMID 17562318.
- ^ Meyer S, Savaresi S, Forster IC, Dutzler R (January 2007). "Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5". Nat. Struct. Mol. Biol. 14 (1): 60–7. doi:10.1038/nsmb1188. PMID 17195847.
- ^ Day P, Sharff A, Parra L, et al. (May 2007). "Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP". Acta Crystallogr. D. 63 (Pt 5): 587–96. doi:10.1107/S0907444907009110. PMID 17452784.
- ^ Rudolph MJ, Amodeo GA, Iram SH, et al. (January 2007). "Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding". Structure. 15 (1): 65–74. doi:10.1016/j.str.2006.11.014. PMID 17223533.
- ^ a b Kemp BE (January 2004). "Bateman domains and adenosine derivatives form a binding contract". J. Clin. Invest. 113 (2): 182–4. doi:10.1172/JCI20846. PMC 311445. PMID 14722609.
- ^ Kemp BE (January 2004). "Bateman domains and adenosine derivatives form a binding contract". J. Clin. Invest. 113 (2): 182–4. doi:10.1172/JCI20846. PMC 311445. PMID 14722609.
- ^ Zhang R, Evans G, Rotella FJ, Westbrook EM, Beno D, Huberman E, Joachimiak A, Collart FR (April 1999). "Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase". Biochemistry. 38 (15): 4691–700. CiteSeerX 10.1.1.488.2542. doi:10.1021/bi982858v. PMID 10200156.
- ^ Rudolph MJ, Amodeo GA, Iram SH, Hong SP, Pirino G, Carlson M, Tong L (January 2007). "Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding". Structure. 15 (1): 65–74. doi:10.1016/j.str.2006.11.014. PMID 17223533.
- ^ Meyer S, Savaresi S, Forster IC, Dutzler R (January 2007). "Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5". Nat. Struct. Mol. Biol. 14 (1): 60–7. doi:10.1038/nsmb1188. PMID 17195847.
- ^ a b Amodeo GA, Rudolph MJ, Tong L (September 2007). "Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1". Nature. 449 (7161): 492–5. doi:10.1038/nature06127. PMID 17851534.
- ^ a b c d Townley R, Shapiro L (March 2007). "Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase". Science. 315 (5819): 1726–9. doi:10.1126/science.1137503. PMID 17289942.
- ^ Jin X, Townley R, Shapiro L (October 2007). "Structural insight into AMPK regulation: ADP comes into play". Structure. 15 (10): 1285–95. doi:10.1016/j.str.2007.07.017. PMID 17937917.
- ^ Kemp BE, Oakhill JS, Scott JW (October 2007). "AMPK structure and regulation from three angles". Structure. 15 (10): 1161–3. doi:10.1016/j.str.2007.09.006. PMID 17937905.
- ^ Gómez-GarcÃa I, Oyenarte I, MartÃnez-Cruz LA (May 2010). "The Crystal Structure of Protein MJ1225 from Methanocaldococcus jannaschii Shows Strong Conservation of Key Structural Features Seen in the Eukaryal gamma-AMPK". J Mol Biol. 399 (1): 53–70. doi:10.1016/j.jmb.2010.03.045. PMID 20382158.
- ^ a b c Lucas M, Encinar JA, Arribas EA, Oyenarte I, GarcÃa IG, Kortazar D, Fernández JA, Mato JM, MartÃnez-Chantar ML, MartÃnez-Cruz LA (February 2010). "Binding of S-methyl-5'-thioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational change in its CBS motif pair". J. Mol. Biol. 396 (3): 800–20. doi:10.1016/j.jmb.2009.12.012. PMID 20026078.
- ^ a b c Ishitani R, Sugita Y, Dohmae N, Furuya N, Hattori M, Nureki O (October 2008). "Mg2+-sensing mechanism of Mg2+ transporter MgtE probed by molecular dynamics study". Proc. Natl. Acad. Sci. U.S.A. 105 (40): 15393–8. doi:10.1073/pnas.0802991105. PMC 2563093. PMID 18832160.
- ^ Hattori M, Nureki O (March 2008). "[Structural basis for the mechanism of Mg2 homeostasis by MgtE transporter]". Tanpakushitsu Kakusan Koso (in Japanese). 53 (3): 242–8. PMID 18326297.
- ^ Scott JW, Hawley SA, Green KA, et al. (January 2004). "CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations". J. Clin. Invest. 113 (2): 274–84. doi:10.1172/JCI19874. PMC 311435. PMID 14722619.
- ^ Tuominen H, Salminen A, Oksanen E, Jämsen J, Heikkilä O, Lehtiö L, Magretova NN, Goldman A, Baykov AA, Lahti R (May 2010). "Crystal structures of the CBS and DRTGG domains of the regulatory region of Clostridiumperfringens pyrophosphatase complexed with the inhibitor, AMP, and activator, diadenosine tetraphosphate". J. Mol. Biol. 398 (3): 400–13. doi:10.1016/j.jmb.2010.03.019. PMID 20303981.
- ^ a b Xiao B, Heath R, Saiu P, Leiper FC, Leone P, Jing C, Walker PA, Haire L, Eccleston JF, Davis CT, Martin SR, Carling D, Gamblin SJ (September 2007). "Structural basis for AMP binding to mammalian AMP-activated protein kinase". Nature. 449 (7161): 496–500. doi:10.1038/nature06161. PMID 17851531.
- ^ Lucas M, Kortazar D, Astigarraga E, et al. (October 2008). "Purification, crystallization and preliminary X-ray diffraction analysis of the CBS-domain pair from the Methanococcus jannaschii protein MJ0100". Acta Crystallographica Section F. 64 (Pt 10): 936–41. doi:10.1107/S1744309108027930. PMC 2564890. PMID 18931440.
- ^ Tuominen H, Salminen A, Oksanen E, et al. (May 2010). "Crystal Structures of the CBS and DRTGG Domains of the Regulatory Region of Clostridium perfringens Pyrophosphatase Complexed with the Inhibitor, AMP, and Activator, Diadenosine Tetraphosphate". J Mol Biol. 398 (3): 400–413. doi:10.1016/j.jmb.2010.03.019. PMID 20303981.
- ^ Shan X, Dunbrack RL, Christopher SA, Kruger WD (March 2001). "Mutations in the regulatory domain of cystathionine beta synthase can functionally suppress patient-derived mutations in cis". Hum. Mol. Genet. 10 (6): 635–43. doi:10.1093/hmg/10.6.635. PMID 11230183.
- ^ Pusch M (April 2002). "Myotonia caused by mutations in the muscle chloride channel gene CLCN1". Hum. Mutat. 19 (4): 423–34. doi:10.1002/humu.10063. PMID 11933197.
- ^ Cleiren E, Bénichou O, Van Hul E, et al. (December 2001). "Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene". Hum. Mol. Genet. 10 (25): 2861–7. doi:10.1093/hmg/10.25.2861. PMID 11741829.
This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.
This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
CBS domain Provide feedback
CBS domains are small intracellular modules that pair together to form a stable globular domain [2]. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain [6]. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet [5]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet [4]. CBS domain pairs from AMPK bind AMP or ATP [5]. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP [5].
Literature references
Bateman A; , Trends Biochem Sci 1997;22:12-13.: The structure of a domain common to archaebacteria and the homocystinuria disease protein. PUBMED:9020585 EPMC:9020585
Zhang R, Evans G, Rotella FJ, Westbrook EM, Beno D, Huberman E, Joachimiak A, Collart FR; , Biochemistry 1999;38:4691-4700.: Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase. PUBMED:10200156 EPMC:10200156
Ponting CP; , J Mol Med 1997;75:160-163.: CBS domains in ClC chloride channels implicated in myotonia and nephrolithiasis (kidney stones). PUBMED:9106071 EPMC:9106071
Janosik M, Kery V, Gaustadnes M, Maclean KN, Kraus JP , Biochemistry 2001;40:10625-10633.: Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region. PUBMED:11524006 EPMC:11524006
Scott JW, Hawley SA, Green KA, Anis M, Stewart G, Scullion GA, Norman DG, Hardie DG; , J Clin Invest 2004;113:274-284.: CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. PUBMED:14722619 EPMC:14722619
Kemp BE; , J Clin Invest 2004;113:182-184.: Bateman domains and adenosine derivatives form a binding contract. PUBMED:14722609 EPMC:14722609
Internal database links
|AAA_15 AAA_16 DHH FMN_dh His_biosynth IMPDH NMO
|Similarity to PfamA using HHSearch:
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000644
CBS domains are small intracellular modules that pair together to form a stable globular domain [PUBMED:10200156]. Pairs of these domains have been termed a Bateman domain [PUBMED:14722609]. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet [PUBMED:14722619]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in cystathionine-beta synthase is involved in regulation by S-AdoMet [PUBMED:11524006]. CBS domain pairs from AMPK bind AMP or ATP [PUBMED:14722619]. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP [PUBMED:14722619].
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
The graphic that is shown by default represents the longest sequence with a given architecture. Each row contains the following information:
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- a link to the page in the Pfam site showing information about the sequence that the graphic describes
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
Note that you can see the family page for a particular domain by clicking on the graphic. You can also choose to see all sequences which have a given architecture by clicking on the Show link in each row.
Finally, because some families can be found in a very large number of architectures, we load only the first fifty architectures by default. If you want to see more architectures, click the button at the bottom of the page to load the next set.
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We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
There are various ways to view or download the sequence alignments that we store. We provide several sequence viewers and a plain-text Stockholm-format file for download.
Alignment types
We make a range of alignments for each Pfam-A family:
- seed
- the curated alignment from which the HMM for the family is built
- full
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- UniProt
- alignment generated by searching the UniProtKB sequence database using the family HMM
- alignment generated by searching the NCBI sequence database using the family HMM
- meta
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
- jalview
- a Java applet developed at the University of Dundee. You will need Java installed before running jalview
- an HTML page showing the whole alignment.Please note: full Pfam alignments can be very large. These HTML views are extremely large and often cause problems for browsers. Please use either jalview or the Pfam viewer if you have trouble viewing the HTML version
- PP/Heatmap
- an HTML-based representation of the alignment, coloured according to the posterior-probability (PP) values from the HMM. As for the standard HTML view, heatmap alignments can also be very large and slow to render.
You can download (or view in your browser) a text representation of a Pfam alignment in various formats:
- Selex
- Stockholm
You can also change the order in which sequences are listed in the alignment, change how insertions are represented, alter the characters that are used to represent gaps in sequences and, finally, choose whether to download the alignment or to view it in your browser directly.
You may find that large alignments cause problems for the viewers and the reformatting tool, so we also provide all alignments in Stockholm format. You can download either the plain text alignment, or a gzipped version of it.
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
|Representative proteomes
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
Download options
We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
|Representative proteomes
|Raw Stockholm
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
If you find these logos useful in your own work, please consider citing the following article:
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
|Seed source:
|Previous IDs:
|Sequence Ontology:
|Bateman A
|Number in seed:
|Number in full:
|Average length of the domain:
|57.70 aa
|Average identity of full alignment:
|20 %
|Average coverage of the sequence by the domain:
|25.86 %
HMM information
|HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
|Model details:
|Model length:
|Family (HMM) version:
|download the raw HMM for this family
Species distribution
Sunburst controlsHide
Weight segments by...
Change the size of the sunburst
Colour assignments
|Other sequences
|Unclassified sequence
Align selected sequences to HMM
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
This chart is a modified "sunburst" visualisation of the species tree for this family. It shows each node in the tree as a separate arc, arranged radially with the superkingdoms at the centre and the species arrayed around the outermost ring.
How the sunburst is generated
The tree is built by considering the taxonomic lineage of each sequence that has a match to this family. For each node in the resulting tree, we draw an arc in the sunburst. The radius of the arc, its distance from the root node at the centre of the sunburst, shows the taxonomic level ("superkingdom", "kingdom", etc). The length of the arc represents either the number of sequences represented at a given level, or the number of species that are found beneath the node in the tree. The weighting scheme can be changed using the sunburst controls.
In order to reduce the complexity of the representation, we reduce the number of taxonomic levels that we show. We consider only the following eight major taxonomic levels:
- superkingdom
- kingdom
- phylum
- class
- order
- family
- genus
- species
Colouring and labels
Segments of the tree are coloured approximately according to their superkingdom. For example, archeal branches are coloured with shades of orange, eukaryotes in shades of purple, etc. The colour assignments are shown under the sunburst controls. Where space allows, the name of the taxonomic level will be written on the arc itself.
As you move your mouse across the sunburst, the current node will be highlighted. In the top section of the controls panel we show a summary of the lineage of the currently highlighed node. If you pause over an arc, a tooltip will be shown, giving the name of the taxonomic level in the title and a summary of the number of sequences and species below that node in the tree.
Anomalies in the taxonomy tree
There are some situations that the sunburst tree cannot easily handle and for which we have work-arounds in place.
Missing taxonomic levels
Some species in the taxonomic tree may not have one or more of the main eight levels that we display. For example, Bos taurus is not assigned an order in the NCBI taxonomic tree. In such cases we mark the omitted level with, for example, "No order", in both the tooltip and the lineage summary.
Unmapped species names
The tree is built by looking at each sequence in the full alignment for the family. We take the name of the species given by UniProt and try to map that to the full taxonomic tree from NCBI. In some cases, the name chosen by UniProt does not map to any node in the NCBI tree, perhaps because the chosen name is listed as a synonym or a misspelling in the NCBI taxonomy.
So that these nodes are not simply omitted from the sunburst tree, we group them together in a separate branch (or segment of the sunburst tree). Since we cannot determine the lineage for these unmapped species, we show all levels between the superkingdom and the species as "uncategorised".
Since we reduce the species tree to only the eight main taxonomic levels, sequences that are mapped to the sub-species level in the tree would not normally be shown. Rather than leave out these species, we map them instead to their parent species. So, for example, for sequences belonging to one of the Vibrio cholerae sub-species in the NCBI taxonomy, we show them instead as belonging to the species Vibrio cholerae.
Too many species/sequences
For large species trees, you may see blank regions in the outer layers of the sunburst. These occur when there are large numbers of arcs to be drawn in a small space. If an arc is less than approximately one pixel wide, it will not be drawn and the space will be left blank. You may still be able to get some information about the species in that region by moving your mouse across the area, but since each arc will be very small, it will be difficult to accurately locate a particular species.
Tree controlsHide
Download tree
- Save a text representation
Selected sequences
- (Uncheck all)
- graphically
- as an alignment
- sequence accessions
- sequences in FASTA format
The tree shows the occurrence of this domain across different species. More...
Species trees
We show the species tree in one of two ways. For smaller trees we try to show an interactive representation, which allows you to select specific nodes in the tree and view them as an alignment or as a set of Pfam domain graphics.
Unfortunately we have found that there are problems viewing the interactive tree when the it becomes larger than a certain limit. Furthermore, we have found that Internet Explorer can become unresponsive when viewing some trees, regardless of their size. We therefore show a text representation of the species tree when the size is above a certain limit or if you are using Internet Explorer to view the site.
If you are using IE you can still load the interactive tree by clicking the "Generate interactive tree" button, but please be aware of the potential problems that the interactive species tree can cause.
Interactive tree
For all of the domain matches in a full alignment, we count the number that are found on all sequences in the alignment. This total is shown in the purple box.
We also count the number of unique sequences on which each domain is found, which is shown in green. Note that a domain may appear multiple times on the same sequence, leading to the difference between these two numbers.
Finally, we group sequences from the same organism according to the NCBI code that is assigned by UniProt, allowing us to count the number of distinct sequences on which the domain is found. This value is shown in the pink boxes.
We use the NCBI species tree to group organisms according to their taxonomy and this forms the structure of the displayed tree. Note that in some cases the trees are too large (have too many nodes) to allow us to build an interactive tree, but in most cases you can still view the tree in a plain text, non-interactive representation. Those species which are represented in the seed alignment for this domain are highlighted.
You can use the tree controls to manipulate how the interactive tree is displayed:
- show/hide the summary boxes
- highlight species that are represented in the seed alignment
- expand/collapse the tree or expand it to a given depth
- select a sub-tree or a set of species within the tree and view them graphically or as an alignment
- save a plain text representation of the tree
Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.
There are 15 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the CBS domain has been found. There are 755 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
Loading structure mapping...


text:
All of this high talk about the Geneva Convention . Well, although not a legal scholar, I'm wondering if the handling of a former Head of State gets identical treatment...
Nevertheless, article 15 of the Geneva Convention applies here:I personally think that it is manifestly obvious that the proceedure under which the former President of the Iraqi Republic was going was indeed a Medical Examination, showing that he is being treated humanely. If your opinion is that his appearance is a disgrace, that is a personal opinion. He was not dressed up in a pink negligee', he was not paraded around in public to derisive jeering... he was, in accordance to the Geneva Convention, removed immediately from the Danger Zone, and given Medical Treatment.Article 15
The Power detaining prisoners of war shall be bound to provide free of charge for their maintenance and for the medical attention required by their state of health.
Article 19
Prisoners of war shall be evacuated, as soon as possible after their capture, to camps situated in an area far enough from the combat zone for them to be out of danger.
I don't think that it is the responsibility of the current Iraqi Regime to make him look dapper and well kept... not is it that of the U.S. Armed Forces.
On the other hand... the Geneva Convention requires of its signatories another act;So all of you folks worried about what may happen to Saddam in the hands of the new Iraqi Courts... rest assured that his rights under the G.C. must still be observed.Prisoners of war may only be transferred by the Detaining Power to a Power which is a party to the Convention and after the Detaining Power has satisfied itself of the willingness and ability of such transferee Power to apply the Convention. When prisoners of war are transferred under such circumstances, responsibility for the application of the Convention rests on the Power accepting them while they are in its custody.


text:
[dropcap]T[/dropcap]he Gallo En Fuego iPad cover is just like the Gallo En Fuego Fire hose wallet we reviewed earlier today as part of the 2013 Father's Day Gift List. The iPad Cover is constructed out of the same genuine decommissioned fire hose that the wallet is. It is a has a double outer layer of polyester, the hose and a rubber liner. Fort Knox could likely be a better protection for your iPad but then you couldn't use it…
A neat feature of the Gallo En Fuego iPad cover is it has a smart feature that wakes the iPad when you open the cover and puts it to sleep when you close it. You can remove your iPad easily from the jacket, and prop it up for a vertical display. It has a pocket in the inside for storing stuff too. It will fit the iPad 2 and iPad 3 only so make sure whoever you are buying for has either of those.
All in all I like this iPad cover very much. I'll have to give it 4 out of 5 stars. I took a star because I feel like companies that make iPad covers should have them fit all the iPads. There are too many not to have all the options and well… it's not fair to get iPad 1 or iPad 4 customers all excited about something that isn't there!
Great stuff from Gallo En Fuego!


text:
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Follow RFF News on your cell phone. Text follow rff to 40404 you will receive txt messages with RFF News
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I got the impression from last night's announcer that Thursday might be a long endurance HOH comp. I don't remember exactly what he said at the end of the show, and I have already erased it from my DVR; but I remember immediately thinking it would be an endurance and not end during the live show. Does anyone else have that impression, or do you remember what was said?
I am very glad that Russell's plan to "work Jeff out too hard" so he wouldn't be able last in a comp will not work as he planned!
Hey all!I haven't posted here this year, or last year? I don't remember, but in light of some things that are going on in the house i feel the need to express my thoughts. Jeff and Jordan have been my favorites since around the first week, and while I agree I would like Natalie out of the house ASAP, I see no humongous difference if they get rid of Lydia this week, then if they get rid of Natalie. My concern is them getting rid of Russel, and losing numbers, giving the other side a chance to win the game. While Natalie could be more of a threat in competitions than Lydia, I still feel like getting rid of Lydia or Natalie is a good thing, and getting rid of Russ is a bad thing. I am pulling for Russel to win POV, so the option does not even come up, and am hoping Natalie OR Lydia leaves this week. This weakens the other side, and I hope this does happen!
oh goodie! poker and liquor PS puddin u were not wrong, we got clarification
Quote from: chinese takeout on August 19, 2009, 12:29:10 AMoh goodie! poker and liquor PS puddin u were not wrong, we got clarification Yeah I admited I was wrong a few posts up. Thats what I get for listening to the HG's ..
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Moderator: The00Dustin
phill wrote:Does anyone have any experience with the DataHand.com keyboard?
barbara wrote:For me, I'm going to try the Typematrix EZ-Reach 2030 http://www.typematrix.com/ezr2030/ in DVORAK.
phill wrote:I guess I can try it out and see, and if I don't like it there is always eBay.
gregvr wrote:I'm using a Microsoft natural wireless, which I don't totally recommend. My biggest problem is that the very large numpad really makes me have to reach for the mouse.
I'm very much considering the Goldtouch keyboard. Price isn't too high, comes in black, etc, etc...
Anyone ever used one of these?
Peter70 wrote:for macs, the keys can be remapped with shareware. As they are, the windows start key is too small to be used comfortable for frequent key commands.
Shawn_Milo wrote:I'm almost two weeks into using the 2030, and it's great. Of course, there are no gestures, but it also costs hundreds less than the TouchStream.
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President Trump Scheduled To Attend Army-Navy GameDan Koob reports.
Philadelphia Weather: Rain Showers Move InKate Bilo has the latest forecast.
A Chat With: Emmy Award-Winning TV Star Carson KressleyJessica Kartalija reports.
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30-Year-Old Man Gunned Down Inside Barbershop In Strawberry MansionNo arrests have been made.
Wake Up Weather: Dec. 14, 2019Kate Bilo has your Saturday Wake Up Weather.
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Enjoy A Holiday Light Show Hayride At Johnson's Corner Farm In MedfordVittoria Woodill reports.
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Johnson's Corner Farm In Medford Is All Decked Out For The SeasonVittoria Woodill reports.


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Conservatives balk at budget deal
It's a familiar tale: Negotiators strike a fiscal deal, conservative lawmakers express resistance, conservative groups threaten primary opposition and headaches ensue for Republican leadership trying to get something through Congress.
It happened during the fiscal cliff. It happened during the government shutdown. And the same elements are starting to appear, possibly creating a repeat scenario as a budget deal takes shape.
Story Continued Below
As Sen. Patty Murray (D-Wash.) and Rep. Paul Ryan (R-Wis.) were only a few hours from announcing a budget deal Tuesday night that would replace some of the sequester and set spending levels for the next two years, conservatives concerned about the debt already are starting to sound alarms — specifically about busting the so-called caps under the sequester that set spending levels at $967 billion for the remainder of fiscal 2014 under the Budget Control Act. Many conservatives view the sequester cuts as harsh but necessary.
( Also on POLITICO: Budget deal reached)
It would take a sizable movement to sink the budget deal — likely requiring more than five Senate Republicans, or more than half of House Republicans, since many Democrats are expected to back the deal — which aides on both sides think is unlikely to happen.
But it doesn't mean that a handful of strident opponents couldn't scuttle an agreement, or at least make a lot of noise about it.
Alabama Sen. Jeff Sessions, the top Senate Republican on the budget negotiating committee, said before the deal announcement was made that he doesn't know yet whether he will back the agreement.
"I don't think anything is a sure deal in the House or the Senate," Sessions said. "Hopefully, it'll be something that people can support, but I'm uneasy about it because Democrats are demanding a lot of things that I think won't be supported."
He added, "It's not going to be a happy experience for most members, liberals and conservatives."
In the House, some of the same group of firebrand conservatives who earlier this year fought to tie spending to repealing Obamacare also are opposed to breaking the sequester caps.
"This slides right in the face of what we agreed to 11 months ago — that we were never going to give up the sequester," said Rep. Tim Huelskamp (R-Kan.).
Furthermore, three conservative groups — Heritage Action, FreedomWorks and Americans for Prosperity — preemptively announced opposition to a budget deal this week. Those groups, which hold sway with the party's conservative base and aren't afraid to wade into primary fights, have used their clout to push Republican lawmakers to oppose fiscal proposals before.
Tim Phillips, president of Americans for Prosperity, said Republicans had given their word that they would hold the sequester cuts in place. And breaking that vow could have consequences.
"We will absolutely hold them accountable if they break their word and go back on the sequester cuts," Phillips told POLITICO.
"These are groups that send some pretty strong messages to the base of the conservative party," Huelskamp said. "We're not going to blame this one on [House Minority Leader Nancy] Pelosi, and I think conservatives across the country are going to be furious."
Fresh off the political fallout from a government shutdown largely blamed on Republicans, the conservatives who have thrown a wrench in the works on previous fiscal deals might not be able to gain the same momentum this time.
The looming $20 billion in cuts to defense spending set to kick in next month via the sequester are motivating some Republicans to back a potential deal who might have otherwise joined some conservatives to oppose it.


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- Changes in the cells of the small blood vessels that can be seen through a microscope


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Tim Stevens was studying English literature and working in a restaurant to make ends meet when he first became interested in wine. He subsequently met winemaker Matthew Loso at a tasting group in what would become a fateful meeting. He worked for two years as Loso's assistant winemaker at Matthews (Loso has since moved on). After a consulting stint with Scott Greer at Sheridan Vineyard, Stevens and his wife Paige started Stevens Winery in 2002.
Stevens Winery has focused on small lot production of Cabernet, Merlot, Syrah, Malbec, Viognier, and Sauvignon Blanc. Formerly a commercial artist, each of the wines bear a unique label every vintage.
The 2009 Stevens Another Thought Sauvignon Blanc comes from Red Mountain's Klipsun Vineyard. While this vineyard is best known for it's powerful, tannic red wines, the 2009 Stevens wine shows that white wines can also excel there as well. The winery's website gives a comical description of the wine stating, "White wine can be a monster to make and sometimes needs a lot of babysitting. We've done our share of watching this little devil and it's paid off; this is our best Blanc yet." Indeed this is an extremely compelling bottle with varietal aromatics of grass and herbal notes complemented by a palate loaded with fruit balanced by crisp acidity.
The front label on the bottle whimsically reads as follows: "Another Thought by Tim Stevens. I think too much and I know it. Mostly the wheels are just spinning. So here's yet another thought. Good wine is good, but I believe that time and space play a role on how really 'great' it may taste. It could be you're laughing with friends so hard you're crying. Sip. Maybe you're sitting on the back deck on a warm summer's night. Sip. You think to yourself, boy does that taste amazing! I hope and pray, that, just maybe, one of my bottles finds this magical place. Anyway, it was just a thought."
This wine did indeed find such a magical place. It is an exceptional summer wine that screams out for seafood. I purchased this bottle from Full Pull Wines, which continues to excel with its hand picked e-mail offerings.
Stevens Winery Another Thought Sauvignon Blanc Yakima Valley 2009 $19
Rating: * (Excellent) An intriguing nose with lime zest, grass, herbal notes, and mineral. Beautifully balanced and rounded on a palate full of crisp fruit flavors and a long, lingering finish. 100% Sauvignon Blanc. Klipsun Vineyard. Aged in stainless steel. 13.9% alcohol. 120 cases produced.
Another Thought from Woodinville's Stevens Winery
Tim Stevens was studying English literature and working in a restaurant to make ends meet when he first became interested in wine. He subsequently met winemaker Matthew Loso at a tasting group in what would become a fateful meeting. He worked for two years as Loso's assistant winemaker at Matthews (Loso has since moved on). After a consulting stint with Scott Greer at Sheridan Vineyard, Stevens and his wife Paige started Stevens Winery in 2002.
4 comments
Paul Zitarelli Says:
Thanks for the call-out, Sean, and I'm glad you liked the wine as much as I did. This has been the summer of Sauvignon Blanc for me. After years of feeling underwhelmed by what the varietal does in Washington, this summer I have tasted three SBs that have been deeply exciting: Stevens, Efeste Feral, and Substance Sb. Bodes well.
Sean P. Sullivan Says:
Paul, this one definitely knocked my socks off. One of the best whites I've had all year. Haven't tried the Sb yet. Will give it a look. Keep up the good work.
Anonymous Says:
Sean, you do great writeups that go hella in depth about the wines and wineries you experience.
Unfortunately, looks like you took a day-off with this one. Stevens Winery is a short drive from CapHill (compared to Walla Walla) so I don't understand why you didn't at least visit the tasting room and try the lineup of wines like I recently did.
I think some of your readers would be curious to know why their wines are ALL labeled "Yakima Valley"...even the Klipsun Vineyard sau blanc (Red Mtn) you purchased from the best store in the world for Washington wines. It's an interesting, though trivial, piece of info that adds to the character of the Stevens couple.
Sean P. Sullivan Says:
WWM, case of inspiration to write about a wine after trying it one night and coming away very impressed. Everyone needs a day off! Haven't had a chance to visit Stevens since last December unfortunately. Have noted the YV labeling and would love to hear the story and try the whole lineup. Have always been impressive.


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Dale Jarrett NASCAR Winston Cup Champion - With Honor And Praise
Dale Jarrett Weathered Racing's Toughest Roads; Now He Begins The Run To Repeat
NASCAR Winston Cup champion Dale Jarrett has been lavished with honor and praise, patted on the back, given standing ovations, and lodged in a suite at the Waldorf-Astoria which he said was "bigger than the first house I lived in." He has been driven around New York City in a limousine, appeared on national television shows, media-blitzed and presented a postseason awards check in the amount of $3,040,767, swelling his '99 earnings to $6.649 million. It seems appropriate to mention that Jarrett earned $35 for Ninth Place in his first race, at Hickory (North Carolina) Speedway in 1977, and that Ned Jarrett, his father, grossed about $14,000 total for winning the 1961 and 1965 crowns.
All these spoils and perks of winning the richest and most prestigious championship in motorsports, of reaching the pinnacle of America's fastest growing sport, Jarrett and his irrepressible Robert Yates Racing #88 Ford team have committed to fresh memory, to be etched in time immemorial. But the final championship celebrations of the century and the pity parties of those less fortunate are over. Reality has returned. A new season has arrived. The slate is clean. The start is fresh. Hope and faith are renewed. There is another championship, richer and more prestigious perhaps, to be won in the new millennium. The question is not who will contend; it's which one will reach the summit of Stock car racing's Mount Everest?
A Bumpy TrackBut first, if there is a theme to Jarrett's story, it is inspiration to others. And Lord knows those who have been turned back at the threshold and others who haven't come close can use all the inspiration they can get. Jarrett's thinking is that goals can be reached through hard work and dedication, that you can do and be anything you want in America. Granted, though, the circumstances must be right and the planets astrologically aligned.
Jarrett, 43, needed 23 years to get to the top after competing in that first minor-league race at the bullring near his Newton, North Carolina, birthplace. Although he excelled in golf, football, baseball, and basketball in high school, the thrill of racing was unlike anything he had experienced and left no question of what he wanted to do for a living. At first, Ned Jarrett discouraged his son because he didn't want him to go through the hard times he had endured, but Ned and Martha ultimately supported their son's decision. The Jarretts had the name but not a silver spoon, unlike what many people perceived; but now they're justly proud of Winston Cup's second father-son champions.
Jarrett is a good man, a gentleman, with strong faith, character, and family and spiritual values, which he attributes to his parents with enrichment from Joe Gibbs and Motor Racing Outreach, the track ministry. Jarrett is a genuine role model, not a model that plays a role. He is a splendid ambassador to the sport, as is his father, who is retiring as the best TV analyst in motorsports. Jarrett is a family man, devoted to his wife, Kelley, their three children, and his son, Jason, 24, a third-generation racer. Kelley has laughed and cried, agonized and celebrated with her husband every step of the way. Also, Jarrett gives unselfishly of himself and to a number of worthy causes.
Typical of most eventual champions, Jarrett's early struggles were filled with heartache and disappointment. Doors opened and closed. Trying to get a grip on Winston Cup in 1989, Jarrett was released by owner Cale Yarborough for lack of sponsorship. The break of his career came when the Wood Brothers called in 1990 and led Jarrett to his first win in 1991, edging Davey Allison by inches at Michigan. Ironically, Allison drove the Robert Yates-owned Ford that Jarrett would eventually inherit.
It wasn't until Jarrett won the 1993 Daytona 500 (passing Dale Earnhardt on the final lap) and finished fourth in points for Joe Gibbs' second-year team that he really gained credentials and clout. In 1995, though, after a tough decision to join Robert Yates to replace Ernie Irvan, recuperating from near-fatal injuries, Jarrett went backward, eliciting boos from fans spoiled by the #28 car and the team's lofty reputation. It was a no-win situation for Jarrett personally. He expected to be fired, and Yates considered it after a lackluster season by the owner's standards. However, Yates, assessing the growing trend toward multicar teams, reconsidered, established the #88 team, and kept Jarrett.
"It's one of the smartest decisions I've ever made," says Yates emphatically. Jarrett certainly seconds that. The #88 Ford Quality Care team has been remarkable since it unloaded in 1996, and Jarrett won his second Daytona 500, again holding off Earnhardt. Led by rookie crew chief Todd Parrott, the team won four races, adding the Coca-Cola 600 at Charlotte and the Brickyard 400 at Indianapolis; they also ranked third in points. Parrott inherited the racing genes of his father, Buddy, and had been a chassis specialist for Rusty Wallace, sharing the latter's '89 championship. But he had never been a team leader. In 1997, the team won seven times and was runner-up in points. There were three more wins and another third in points in 1998.
According To PlanWinning the '99 championship was a plan, not an afterthought. After the '98 season, team principals Jarrett, Parrott, Yates, and his son, engine specialist Doug Yates, evaluated what they had done and what they could do to win the championship. They had watched young Jeff Gordon win three titles and Hendrick Motorsports win four in a row. Points, not victories, were given top priority. It appeared the best-laid plan had gone awry when Jarrett crashed out of the season-opening Daytona 500, finishing 37th. But that turned out to be the team's only DNF, and they finished in the 30s only once in the next 33 races of a dream season.
Jarrett took the points lead in the season's 11th race with a victory at Richmond and seldom looked back, extending the margin as high as 314 points, clinching the inaugural Winston Cup race at Homestead-Miami and winning by a commanding 201 points over Bobby Labonte. Jarrett gave a clinic on how to use a system that, simply stated, demands and rewards consistency. Jarrett used his talent and equipment superbly. "I'm not the most talented driver out there," he says. "Mark Martin, Jeff Gordon, and Dale Earnhardt are more talented, so I have to work harder to utilize best what I have." If victory was out of reach, he made darn sure he came home in the top 5 or 10. Three other competitors won more races than Jarrett's four-Gordon, Jeff Burton, and Bobby Labonte.
But Jarrett logged an amazing 24 top 5s, 29 top 10s, and an average finish of 6.7. The average finish, an obscure statistic, is telling in a championship grind. Generally, an 8 or lower will get you a championship. By comparison, Bobby Labonte compiled an average finish score of 9, and Third-Place Martin earned 9.35. Gordon, in spite of his circuit-leading seven wins, skied to 12.9.
"I get most of the credit because I'm called the Winston Cup champion," Jarrett says, "but really, I'm the lucky guy who got to sit behind the wheel of the incredible cars and engines Todd and Doug and their guys gave me. We had no mechanical failures." At the team's '98 Christmas party, Jarrett had given each member a card that read, "It's amazing how much can be accomplished when no one cares who gets the credit."
Jarrett and Robert Yates' first champion-ship is exceedingly popular and richly deserved. Jarrett had not considered winning a championship until he came to Yates. It wasn't a vision. "I felt I would have had a better chance jumping off the Empire State Building and living than winning a championship," he says. Yates was incredulous, even when the title was wrapped up.
Jarrett says he wanted to win the championship most for Yates, whose 11 years as a car owner were tear-stained by the tragic death of Davey Allison in a '93 helicopter crash and the terrible injuries to Irvan. Allison was running fifth, where he needed to finish to win the championship, in the '92 finale at Atlanta, but collided with a car driven, ironically, by Irvan. In 1994, Irvan stood second in points when he crashed #28 in practice at Michigan.
Going For TwoCan Jarrett and #88 repeat? Sure they can. The team is intact, and the 2000 Taurus should be as good or better than the '99. Yates has added five pit crewmembers that departed Gordon's team, but whether this will have a positive or negative effect remains to be seen. Jarrett is one of the eldest champions, and there may not be too many more opportunities, although he's never been in better physical condition. He looks fit enough to return to the quarterback position at Hickory High.
Ricky Rudd, having taken over #28, makes Yates a double threat to repeat. A 23-year veteran, Rudd has cracked the top 10 in points for 16 of the past 20 seasons. Although his series record of at least one win per season came to an end at 16 years, he's a proven winner and appears to be in the best position to win his first title.
Other leading challengers include Mark Martin, Bobby Labonte, Tony Stewart, Jeff Burton, Jeff Gordon, and Dale Earnhardt. With the dynamic duo of Bobby Labonte and Stewart, Joe Gibbs Racing may have the edge. In terms of wins and points, Bobby Labonte was almost three times as good last season as in 1998. Stewart was sensational, the season's biggest surprise while rewriting the rookie record book with three wins and fourth in points. Chevrolet and Ford competitors grouse about the Pontiac having an aerodynamic advantage. It's not the car; it's vastly improved teams.
A first title for Martin and Roush Racing is past due. Martin is truly the sentimental favorite after finishing in the top six in points for 11 consecutive years, including runner-up twice. The fitness guru drove hurt much of last season, but the injuries from a crash have healed, and much of the pain from a chronic back ailment has been relieved by surgery. Hey, maybe that's an omen. Perhaps off-season surgery is a ticket to the championship. Remember Jarrett's highly publicized gall bladder operation after the '98 season? Who wouldn't give a gall bladder for a championship?
Roush's Burton, the best young driver of record behind Gordon, is a champion-ship waiting to happen. His six wins in 1999, four more than in 1998, ranked second to Gordon, and he finished in the top five in points a third straight year. Burton, like Martin, lacked the prime ingredient: consistency.
Gordon, even with the most wins and seven poles, had an off season by his standards, not unexpected given that he had dominated with 33 victories and two of his three titles in the three previous seasons. Gordon's '99 bid was in trouble after the first third of the season, and he played catch-up to finish sixth in points. In the first 12 races, Gordon fell victim to five of six DNFs and five of eight finishes in the 30s or 40s, in spite of his second Daytona 500 victory among two others. The sudden departure of crew chief Ray Evernham and the turmoil surrounding the Hendrick Motorsports flagship was another blow. Back-to-back victories made Evernham's absence appear insignificant and successor Brian Whitesell look like a genius, but the team struggled to only two 10th-Place finishes in the remaining five races. In the off-season, Whitesell was promoted to team manager and veteran Robbie Loomis, a top wrench at Petty Enterprises for a decade, came aboard as crew chief. Look for Gordon to rebound. Exactly how far, though, is questionable.
Earnhardt embarrassed those who had relegated him to a rocking chair. At 48, The seven-time champion made an amazing comeback, winning three races-two touchdowns and a dropkick (at Bristol)-for the first time since 1995 and improved a position, to seventh, in points. He also bore a striking resemblance to the Intimidator of old, restoring bragging rights to his army of fans. Don't dare preclude a record eighth crown.
Also give calls to Ward Burton and Bill Davis Racing, the only single-car team to finish in the top 10 in points; to Rusty Wallace, who extended his winning streak to a circuit-leading 14 straight years but slipped four spots in points; and to Terry Labonte. The two-time champ dropped from 6th to 12th in points with one win. But he is reunited with crew chief Gary DeHart, who led the #5 Hendrick Motorsports team to the '96 championship.
Much of the appeal and allure of Winston Cup racing, however, is its fickle unpredictability.


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Please include a quiver with each future release of any figure equipped with a crossbow, or better yet please release a new quiver element that hangs at the waist like the indiana jones satchel.
Or if it's not possible could we have the quiver accessory as a permanent element on pick a brick. Thanks


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Alton Jones' 3 favorite bass lakes
By Craig Lamb
Alton Jones Sr., Skeeter sponsored angler, has spent the past 27 years fishing his way across the country from East to West, and North to South. Currently, the Bassmaster® Elite Series pro from Texas spends nine months of the year competing on the hottest bass lakes in the nation.
Which are his favorites? When are the best times to go? What patterns and baits are best? Find the answers, get inside tips, and plan your trip to his top three bass fisheries.
#1 Falcon Reservoir, Texas
What makes it special: "Years of drought followed by wet seasons make it cycle through and fish like a new lake," says the 2008 Bassmaster Classic® winner. Drought exposes the bottom, vegetation sprouts on the dry ground, and then gets inundated when the water level returns to normal. The vegetation doubles as spawning habitat and a nursery for baby bass to protect them from predators. "The bass grow big and are easy to catch. There is no place else in the country you can go to potentially catch a double-digit largemouth on every cast."
Best time to go: April through July. "The bass get so far back, hundreds of yards or even miles, that anglers cannot reach them during the spawn, which is also why the lake is so productive," says Jones. Receding water during summer pulls the largemouth to deep dropoffs, where they school in large numbers and are easier to locate.
Favorite patterns and baits: Deep diving crankbaits like the Norman DD22 and Bomber Fat-Free Shad. Also, Texas rigged 10-inch Yum® worms. Jones suggests flipping the rig into bushes and hanging on. "I can't keep count of how many times a big bass got the better of me in the bushes on a Texas-rigged worm.
#2 Lake Champlain, Vermont and New York
What makes it special: Sheer size. The lake stretches 106 miles along the Vermont and New York borders and covers over 313,000 acres. "There are always untapped fishing areas, places you can go that are unpressured," explains Jones. "The lake also supports habitat for largemouth and smallmouth, so you get the better of two worlds. Take your pick on any given day, largemouth or smallmouth, and bite on a good, consistent bite," he adds.
Best time to go: Anytime except for winter. An ideal time is late summer, and Jones especially favors September. "The bass know the cold is coming and the shallow bite is phenomenal, a power fisherman's dream," he says.
Favorite patterns and baits: Heddon Super Spook Jr., clear pattern, fished on shoals and rocky points near deeper water. "The smallmouth can see the lure on the bottom at 15, 20 feet, and will charge at it," he says. "You cannot beat the exhilarating rush of a hard-charging smallmouth hitting a topwater lure."
#3 Upper Mississippi River
What makes it special: "The quality in numbers of 2- to 4-pound largemouth, more so than anywhere else I fish," he says. An abundance of habitat is the reason. "The only place that is not bass habitat is the main river, the navigation channel." Envision acres of backwaters filled with fields of lily pads, lush hydrilla, milfoil and native vegetation. The vegetation doubles as a nursery for baitfish and ambush points for the bass.
Best time to go: July through September. "The water is more stable and not so flood-prone by then," he says. "Plus, the vegetation is more lush and mature."
Favorite patterns and baits: Booyah Pad Crasher Frog. "You get the anticipation factor of watching the vegetation roll up behind the bait from an approaching bass," says Jones. "Let the bass take the bait under before setting the hook." Jones also likes a 1/2-ounce Booyah® Jig with soft plastic grub for a strike-enhancing trailer. "Slow roll it like a spinnerbait around the edges of thick, matted vegetation," he adds. The bass awaits in ambush beneath the darkness of the vegetation until bait appears in open water.
Gaining access to all of the above requires a boat, but not just any rig.
"If you notice all my favorites are large bodies of water," says the veteran pro. "My Skeeter FX21 is designed to handle any kind of water and is specially designed for making long runs across rough water.
It's a wave tamer of a boat, and I feel safe, while not compromising performance at the same time," he says.
Pros like Jones also carry a lot of gear. There is no going back home and getting what is needed for a given day on the water. The interior layout of the FX21 is what appeals the most to Jones.
"Even more importantly, the FX21 is the best-designed boat for tackle storage and organization," he says. "I can organize all of my tackle for every bass fishing situation I encounter during the season."
"The Skeeter is the best bass fishing platform out there for me," he says.
Learn More at Skeeter Boats.com
This document contains many of Skeeter's valuable trademarks. It may also contain trademarks belonging to other companies. Any references to other companies or their products are for identification purposes only and are not intended to be an endorsement.
Original Source: Sportsmans Lifestyle.com


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Here is one evil pony that I wouldn't want to cross any time in my life. She is a dark soul that has nothing but hatred for the My Little Pony gang. I was asked to make a lesson based on Queen Chrysalis, so here it is. Today I will be showing you "how to draw Queen Chrysalis", step by step from the MLP series. I'm pretty sure she made her first debut in the twenty fifth episode called 'A Canterlot Wedding' which was broken up in two parts. She is the main antagonist in the episodes, and her main goal is to cast a spell over Shining Armor so he can no longer protect the city. Originally Queen Chrysalis was called queen of challenges when she was first created. But as time went on she goes by the name she has now, which I think suits her well. One of the things that the evil Queen will do is shape shift into other ponies like she did in Canterlot Wedding when she impersonated Princess Candance. Even though she is not the friendliest pony in the series, she is still very cool to recreate. I just know that a lot of you MLP fans will enjoy drawing Queen Chrysalis because I know I did. I will return with a dragon tut so stay tuned in to Dragoart.com.
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