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Unswung: McIntire boots Sunday golfers
For the second year, Charlottesville has claimed the McIntire Park Golf Course for the general public on Sunday afternoons, a move that signals changes ahead for the funkiest– and cheapest– course in town.
The Meadowcreek Parkway looms as one threat to the nine-hole course, which is tucked away behind the wading pool on the eastern end of the park and a little tricky to find if you go driving up to the main entrance to McIntire Park.
Part of the Sundays in the Park strategy is to give the McIntire Park Steering Committee feedback for its redesign efforts.
From noon to dusk starting August 31, the public may picnic and stroll through the course and its sand– yes, sand– putting greens without fear of being beaned by a golf ball.
At one time, disgruntled duffers were outraged at any threat to their beloved course, and wrote letters to the daily paper pleading for its survival.
The reaction to the loss of Sunday afternoon playing time has been more muted. "I don't think we got a lot of complaints last year from golfers who can't play on Sundays," says city spokesman Maurice Jones.
On an August Thursday afternoon, Bob Moody is the only golfer on the McIntire Park Golf Course. He isn't bothered that he won't be able to practice on Sundays, noting that Sunday afternoon is not prime golfing time.
"Saturday would be more of a problem," says Moody, suggesting that weekdays are prime time for the most avid golfers.
Despite its being deserted this particular afternoon, Moody says the McIntire course is "well played" by a lot of UVA students and senior citizens. "I enjoy this out here," he says. "There's not much of a crowd. If this hole is occupied, you go here instead."
More than the Sunday closing of the course, he says, "Everybody's concerned with the Meadowcreek Parkway, and then there won't be a golf course." However, city officials say they don't know for sure yet whether the parkway means the end of the golf course.
Playing at McIntire costs only $2 for residents, and it's paid by the honor system. Not surprisingly, it's not a big revenue generator for the city, says Jones.
Does that mean that strollers could win out over golfers, whose sport won out over hiking trails at Pen Park back in the early '90s?
The committee hasn't made any decision– yet– about the fate of the golf course. Says Jones, "They're waiting to get as much feedback as possible from the public."

subset: commoncrawl


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A few years ago, at the start of a new school year, I announced to the kids that we would be memorizing the book of James.
"The whole book?" one son asked, eyes wide with surprise.
"That's the goal," I responded.
"Impossible!" he declared.
Up to that point, my children had memorized single verses and short passages of Scripture. I thought it was time to take on something bigger.
Memorizing God's Word


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Oroville >> A 21-year-old man was placed on five years probation for his role in a January 2013 attack on two victims on a Paradise bicycle path.
Butte County Superior Court Judge Kristen Lucena initially sentenced Alan Gediminas Steen to seven years in state prison, but she stayed the imposition of the sentence in light of a mental health condition Steen has. Lucena also said the defendant was youthful and it appeared he would respond well on probation.
The probation term included a total of 270 days in jail, completing a residential treatment program and an order to stay away from the victims.
Paradise police arrested Steen and Nathan Hendrix following a Jan. 27, 2013, attack on an 18- and 19-year-old, according to the Paradise Post at the time. Hendrix, who was 16 years old at the time, was charged as an adult.
Officers said Hendrix and Steen approached the victims on the bike path north of Maxwell Drive. Hendrix allegedly stabbed one of the victims several times with a folding knife. Steen reportedly attacked the second victim to keep him from helping.
The defendants allegedly fled. A family member took the victims to Feather River Hospital, where police were called at 10:20 p.m.
At the time police indicated the incident may be gang-related.
On Thursday, supervising deputy district attorney Marc Noel said outside of court that Steen reportedly identified himself as a Juggalo, which is primarily a fan of the hip-hop music group Insane Clown Posse. The FBI included Juggalos in the 2011 National Gang Threat Assessment, writing that some subsets have engaged in criminal activity. The group has challenged the classification in a federal lawsuit.
Noel said Hendrix allegedly asked to be part of the Juggalos. Steen reportedly said Hendrix needed to kill someone, which led to the attack. Steen reportedly said he had killed more than 30 people.
The prosecutor said both defendants have mental health issues, but not to the level of criminal insanity.
Hendrix and Steen were charged with attempted murder. Steen pleaded no contest Sept. 13 to an added felony count of assault with a deadly weapon with a great bodily injury enhancement.
Hendrix has pleaded not guilty and not guilty by reason of insanity. He was scheduled to appear in court Thursday for the receipt of a mental health report before setting a trial date.
When Judge Lucena placed Steen on probation, she noted the defendant had a mental health condition but it couldn't be used as a defense in the case.
The judge warned Steen that any probation violation could result in the imposition of the sentence. In determining the case merited an upper-term sentence, Lucena said Steen accepted a leadership role in including Hendrix in the unprovoked, random attack.
Steen was taken into custody to serve the remainder of his jail term, but Judge Lucena authorized his release to a treatment facility.
Hendrix remains in custody.
Reach reporter Ryan Olson at 896-7763.


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This Darice® Mix and Mingle set features large hole beads that are lined with silver metal and accented with shades of green. Each set includes 4 beautifully detailed green glass beads, 2 faceted medium green crystal beads, and 3 silver spacer beads with clear or emerald green rhinestones. 9 pieces per package.
Darice® Mix and Mingle beads are a great way to commemorate special occasions--or to match your mood, season or outfit! Slide these beautiful and affordable metal lined glass beads onto necklaces, bracelets and more.


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Oakland saves best for last, beats O's
Baltimore falls 5-4 on road against A's
Josh Donaldson hit a three-run homer in the bottom of the ninth inning, sending the Oakland Athletics to a stunning 5-4 comeback victory over the Baltimore Orioles on Friday night.
Donaldson's drive over the wall in center off Zach Britton (3-2) sent the A's streaming out of the dugout in front of an announced crowd of 27,232 at the Coliseum. It was Donaldson's fifth career game-ending hit and third career game-ending homer.
The much-booed Manny Machado had lined a go-ahead, two-run homer in the seventh, and Jonathan Schoop hit a two-run homer in the fifth that appeared to be enough for the AL East-leading Orioles. But beating the best team in baseball -- especially at home -- has never been easy this season.
Eric O'Flaherty (1-0) tossed one scoreless inning for the win, Oakland's major league-leading 60th.


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|{Images via El Vintage Blog/El Vintage Etsy}
|Emily's Blog
And here is an interview with Emily from El Vintage so you can get to know a little about her!
-When everyone around me is happy.-When I have my dogs next to me.-Shopping for vintage.-Coming up with a new clothing or accessory line.-Traveling the world
My love for individual style instead of following a fashion magazine...and the millions of inspirations when I travel to European cities.
It means timeless. It means forever original and in-style.
My new Luxe necklace line. I am really excited about it and think the piecesare completely rock star amazing!
|....Would make a very proper pumpkin patch date outfit ;)
belt, bag, dress, boots
|clutch, camisole, dress, Kimono


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AMERICUS - With all goals coming in the second half, the Georgia Southwestern women's soccer team defeated Brewton-Parker College, 3-0, on Wednesday afternoon at Hurricane Field. The Lady Hurricanes, winners of two straight, have won consecutive 3-0 decisions.
Despite rattling off a season-high 13 shots in the opening 45 minutes, GSW could not break the scoreless tie until the second stanza.
Hannah Burnsed made her first six saves for Brewton-Parker (1-5) to keep the match even until the 54th minute. That's when Julia Wells poked in a deflected shot from Zada Hyatt for her first goal of the season.
The lead quickly doubled as just over a minute later Jennifer Starvetsky found the back of the net off a header from eight yards out with Hyatt picking up the assist.
GSW tacked on the final goal in the 66th minute when Ally Canganelli's low punch from inside the box angled far post past Burnsed for her second goal of 2011.
The Lady Hurricanes finished with 23 shot attempts, the most in a match since posting 58 on Oct. 20, 2008 at Wesleyan College. The 12 corner kicks on Wednesday is a school record.
Starting GSW goalkeeper Amber Bahri and freshman Jordyn Birchett teamed for the Lady 'Canes second shutout of the season. The Southwestern defense held BPC to two shots and no corner kicks in the match.
GSW had lost the previous two meetings with the Lady Barons by a combined 6-1 score and Wednesday's victory marks the second time Southwestern has defeated BPC in six attempts.
The Lady Hurricanes (3-4) look to make it three "W"s in a row on Saturday when Georgia College comes to town to open Peach Belt Conference play at 5 p.m.


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StruxureWare Energy Operation raises the bar for easy energy information access at Earth Rangers Centre
Earth Rangers™ is a Canadian non-profit organization that promotes the importance of protecting biodiversity and the adoption of more sustainable behavior through community events, online education, and a positive science. Earth Rangers has successfully applied their message and positive science to their 60,000 square foot (5600m²) facility, based outside of Toronto, to make it one of the most energy-efficient buildings on the planet.
A results-oriented partnership
Earth Rangers was looking for partners who could donate equipment and expertise, and in 2009, Schneider Electric™ came onboard as their building automation, metering, security, and lighting controls supplier. The first installation included: Schneider Electric building automation hardware and software, power monitoring and energy management tools, Juno lighting, Pelco cameras, and PowerLink/Clipsal lighting controls. Significant savings and benefits were realized, but true to the organization's values, Earth Rangers wanted to do even more. After earning LEED (Leadership in Energy and Environmental Design) Gold for New Construction certification, Earth Rangers decided to further demonstrate their commitment to reducing energy use and CO₂ emissions by pursuing a LEED Platinum for Existing Buildings certification—the highest level of certification offered under LEED.
"The fact that our building is 83% below the national average energy usage of a standard building sets an outstanding example of the mindset we want to encourage in children," says Peter Kendall, Executive Director, Earth Rangers. Indeed, green building designer professionals from around the world visit the facility to study its energy-efficient design and operation. "But, if we want to set the standard for how to operate a truly energy-efficient, "green" building, it's vitally important that we continue to reduce our facility's energy usage."
Hosted energy management solution delivers tangible benefits quickly
Schneider Electric recommended hosted StruxureWare Energy Operation software, an advanced energy management information system that leverages existing real-time monitoring and control systems with:
- automated tools to identify, analyze, and report on energy savings and sustainability initiatives
- automatic transfer of energy monitoring system data to a public facing display kiosk and corporate website
- verified utility billing data and reports providing insight on power sent back to the grid through on-site generation
- powerful management tools to validate the effectiveness of their energy savings initiatives and investments, helping document the true return on investment in dollars, kWh and CO₂ saved
Utilizing professional design and commissioning from Schneider Electric, the upgraded installation was up and running by July 2011. Anchored by intuitive Energy Operation software, the new solution began providing actionable energy information to help Earth Rangers save time, reduce effort, and improve total facility energy performance. Key energy data was centralized into a single "facility scorecard" view for straightforward energy monitoring, real-time and historical analysis, and reporting. This key performance information enabled staff to evaluate and justify new energy efficiency building improvements, while detecting and correcting poor energy efficiency in building automation, control, and HVAC systems. According to Andy Schonberger, Director, Earth Rangers Centre, "Energy Operation allows us to visualize integrated information from different platforms. At the click of a mouse, up-to-date energy metering and building automation tracking information are brought together into a package that is understandable to a building operator, manager, or the general public."
Recognition for outstanding green building achievements
What's more, StruxureWare Energy Operation contributed substantially to Earth Rangers achieving certification to LEED Platinum by helping the organization target multiple credits under LEED Existing Building, namely Energy and Atmosphere Credits 3.2 and 3.3 (system level metering), along with Water Efficiency Credit 1.1 (sub-metering and reporting). Additional benefits include 20% year-over-year reduction in energy consumption and greenhouse gas savings of 444.2 tons of CO₂. Partnering with Schneider Electric was the right move for Earth Rangers. "Upgrading our building from LEED Gold to LEED Platinum required us to continue reducing energy usage. Schneider Electric building automation/energy management solutions helped us achieve this goal and gave us a much better view of where energy is being used in our facility and the intelligence to help us optimize energy usage to the point where we are completely self-sustainable," says Kendall.
- Watch how the Earth Rangers are building a greener future.


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Last updated: April 26, 2013
E-mail Donald at firstname.lastname@example.com
Read how Donald found his 24-year-old half-sister,also a survivor of sexual abuse at the hands of their "father".
Donald Reaches Out to His Lost Brother Over Christmas 2011Article originally printed in London Free Press, Dec 24, 2011
Any day I wake up above ground, Im happy. I know too many dead men and women walking.
My youngest brother, Erik, whos been living off and on the streets of Vancouver for over two decades, is one such person.
My family hasnt seen him in 14 years.
A couple of years ago, I wanted to donate some money to the Kettle Friendship Society that feeds the homeless in Vancouver like my brother.
Unfortunately, around that time and the last time I spoke to my brother (when he called collect from a phone booth), he told me he was banned from the Kettle because of fighting with another guest. So it didnt make sense to send them money when he couldnt even get in the door to benefit from their services.
So I thought of something else. The Palace Theatre on Dundas St. was continuing its restoration process. They were refurbishing seats at $200 a pop. My brothers name is on one of those seats now a small plaque. I wanted him to somehow have something permanent, something to say: Yes, you were here; you matter.
Or was it me who wanted, needed something permanent?
Thats what you do when you have a loved one you cant reach, someone who lives on a street with no name. You crave something tangible. Well, you do during the moments that arent spent dreading an imaginary phone call that will tell you somebody found his/her body.
Eriks life on the street actually began soon after a very real call I received in 1982, when he was 15.
Your brother took an overdose of drugs and is barely hanging on to life. Weve transported him to a London hospital. Meanwhile, I would prepare funeral arrangements.
Its difficult to describe the 29 years since that moment. A perpetual suicide watch. Its unfortunate too many know exactly how my family feels. Its like walking around with a knife in your heart. You laugh, you live, but its always there.
So imagine my joy when I recently received an e-mail from a Living Waters Mission minister in Vancouver telling me she had seen Erik.
He is not well, but he is alive. He is staying at a hotel.
By an odd coincidence, that same weekend I attended the University of Western Ontarios musical South Pacific. These words kept ringing thereafter in my head:
Once you have found him,
Never let him go.
I contacted Gloria, this minister, or angel as I see her, and asked, If I send you a money order, would you treat yourself and Erik to the biggest buffet dinner you can find in Vancouver?
Well, she wrote me just last night. She took my brother to Uncle Willys in Burnaby. She didnt tell him until he was done his meal that I had arranged it and thankfully, rather than be upset, he was thrilled.
Remember I mentioned craving something tangible?
Gloria sent an attachment: a photograph of my brother sitting across from her in the restaurant toasting her.
The first photograph we have of our brother in 14 years.
Erik is still a prisoner of his own war. But this year is yet another he hasnt been declared a casualty.


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When a friend told Hollie Toups that topless photos of her had been posted on an Internet pornography site, she felt horrified, but she didn't feel alone: She recognized more than a dozen other South Texas women on the website, she said.
Last Friday, Ms. Toups and 16 other women filed a civil lawsuit in Texas state court against the site, Texxxan.com, alleging that their intimate photos were posted illegally and included information that made them easy to identify. They are seeking damages and to have the site closed down.
Legal experts say they are seeing an increasing number of such lawsuits targeting so-called revenge porn, in which intimate images are posted online, often by jilted former lovers but also by computer repairmen or hackers who gain access to private photos. Some sites feature pornographic images alongside links to a subject's social-media accounts and other identifying information.
"I'm not saying I'm perfect, but I've been exploited," said Ms. Toups, a 32-year-old graduate student in criminal justice, who lives outside Houston. She said she had sent the photos years earlier to a former boyfriend, wasn't sure how they had ended up on the Internet, and hasn't sued the former boyfriend. She said the photos appeared on the website alongside a link to her Twitter account and clothed photos she had taken of herself and never distributed.
The administrator of Texxxan.com could not be located, and an email message sent to the site received no response. The suit also names GoDaddy.com as a defendant, claiming it hosts Texxxan.com. GoDaddy.com declined to comment on the suit.
The lead lawyer for the Texas plaintiffs, John Morgan of Beaumont, Texas, said he plans to sue the owners and operators of the porn site once he learns their identities.
"None of these women consented to having their photos used," Mr. Morgan said, adding that all of his clients subsequently suffered bouts of depression. "This site has to be shut down."
Finding the operators of porn sites can be difficult, as is persuading the police to investigate, legal experts said.
Federal law offers broad protection to sites that merely publish pornographic images taken by others.
"I wish we had more robust legal protection," said Danielle Citron, a University of Maryland law school professor who is working on a book about online harassment. She added that civil suits can be prohibitively expensive and victims often don't want further publicity by bringing litigation. "If you have to sue in your own name, the privacy invasion can be worse," she said.
Still, there are many legal options available to victims, according to lawyers across the country, who say people can sue for copyright infringement if they snapped the photos that later end up online without their consent.
Other potential claims include invasion of privacy and infliction of emotional distress, lawyers said.
"I have never even had to file a suit" to get porn sites shut down, said Kyle Bristow, a lawyer in Toledo, Ohio, adding that he has represented about a half-dozen clients, of both sexes, in such cases. "Just by putting people on notice that I'm coming after them has sufficed."
Erica Johnstone, a San Francisco lawyer who has represented about a half-dozen victims of revenge porn sites, said that "the emotional toll on women can be devastating," and includes depression and anxiety.
Ms. Toups said she at first became reclusive last summer, when she learned that her revealing photos had landed online. "I shut everyone off but my mom," she said, adding that when people greeted her in public, she wondered, "Is it because they are polite or have seen me topless?"
Texxxan.com, she said, allows subscribers to search for images of women according to regions of the state where they have lived. When she searched southeastern Texas, she found many other women she knew.
"I felt it was my duty to reach out to them and ask if they knew they were being harassed," Ms. Toups said.
Copyright ©2019 Dow Jones & Company, Inc. All Rights Reserved. 87990cbe856818d5eddac44c7b1cdeb8


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CoCensus: Engaging with Census Data in the Museum
At the University of Illinois at Chicago, researchers Leilah Lyons and Josh Radinsky have formed a partnership with the Jane Addams Hull-House Museum to develop CoCensus, an innovative museum exhibition that will ultimately allow visitors to interact with Chicago census data in engaging new ways. Funded through the Digital Humanities Start-Up Grants program and currently in the prototyping stages, the exhibit uses RFID (Radio Frequency Identification) cards that will hold information about museum visitors' self-identified racial, ethnic, or national background. Equipped with a wireless card, visitors will then be able to interact with a map display that uses their demographic information to depict a visual representation showing where present-day Chicagoans who reported the same ancestry in the 2005-2009 American Community Survey were living. For instance, if your family immigrated to the United States from Mexico, on the map would appear color-coded data showing where Chicagoans of Mexican ancestry were living in 2005-2009. As multiple visitors move toward the map, Microsoft Xbox Kinect technology will track their movements to visually distinguish data related to individual participants and help them understand how communities with different historical identities continue to live in relation to one another.
The project team is working with museum visitors to complete a number of trials on the pilot exhibit, and plans to continue refining and developing it in the future to include additional maps, historical time periods, and other data exploration features that might extend to different museum contexts. By answering a few of our questions below, Leilah and Josh shed light on the project's background, its goals, and the complexity of the design process.
How did the idea for this project come about?
Dr. Lyons' lab had been developing and studying novel approaches for employing technology within museum exhibits to support collaborative learning in science museums, while Dr. Radinsky had been studying ways data visualizations of Census data could be used by teachers and students in history classrooms. Both were intrigued by the possibility of combining their research interests in a new context, and saw the potential value in creating a museum exhibit that would allow visitors to interact with large data sets in a museum focused on social history and immigrant identity.
In what ways are you collaborating with the Hull-House Museum? How does this project relate to the museum's mission and other initiatives?
Prior to designing anything, our team spent extensive time in the museum, both in the context of drop-in visits as well as attending tour groups conducted by the museum staff…We specifically discussed the connection of modern GIS census data to the Hull House's pioneering demographic mapping work performed in the late 19th century (The Hull-House Maps and Papers), which marked a pioneering use of spatially-mapped demographic information to advocate for social change. We view our exhibit as a more modern take on the Hull-House Maps and Papers, providing visitors the opportunity to reflect on their personal connections to these communities, and (in the next phase of the design) on how immigrant communities in Chicago have changed over the decades. The Hull House has a strong orientation towards advocacy not often seen in museums; their goal is to help visitors see themselves as possible agents of change. We hope that our exhibit can help visitors start asking the kinds of questions that lead one to think deeply about identity, community, and social change.
What have you found challenging or surprising?
We've been surprised by how the different versions of the exhibit design supported very different kinds of visitor conversations. Even "small" changes in the visualization design and in the interaction design resulted in different conversations about the data, and different expressed conceptions about place and identity. In terms of challenges, we've needed to do more work than we had expected to find a good set of interaction strategies that are well-suited to the context of this museum, both in terms of accommodating the activity preferences of their typical visitors and to the peculiarities of constructing a digital exhibit in a historical building. Another challenge arises from the fact that the visualization design has to support dynamic representation of the data – this imposes very different design requirements than what is typically found in static displays of geospatial data, and has challenged us to find appropriate and effective ways to visualize data when it is responsive to visitor actions.
How might your project serve as a model for others in cultural heritage organizations or other settings?
We hope that the design strategies we have uncovered for both the interaction with, and visualization of, large data sets can be adapted by other informal educational settings in which the public can explore large, spatially-referenced data sets. Another interesting model is our collaborative process itself – far too often the design of new interactive technologies is driven either by content specialists who do not necessarily understand how to best leverage the affordances of emerging technologies, or by technologists who understand the technology but do not necessarily understand the critical nuances inherent in the content…We structured our process so that the design would evolve through the continuous co-participation of all partners in the grant, and the repeated exposure to each other's worlds of concern (whether they be discussions of the perceptual salience of transit lines on the map, or debates on the most effective data structures for quickly updating data points) helped each side better understand the varied motivations driving the project, and allowed us to make ever-wiser design decisions as the project progressed. We hope that our project can serve as a model of how a meaningful cross-disciplinary collaboration can take place.
[Note: This Q&A has been edited for length.]


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Gov. Jerry Brown has come under criticism for dropping a Schwarzenegger-era lawsuit that sought to clarify whether California governors have the power to reduce state workers' wages temporarily to the federal minimum wage when the state budget isn't passed on time.
The argument is that Brown is caving to his key political backers, the public employee unions, who say governors can't reduce those wages. Maybe, but Brown's decision makes sense anyway, for political, legal and budgetary reasons.
Politically, the lawsuit represents a fight that Brown doesn't need right now -- as he tries to get public employees and other Democratic interest groups to go along with budget cuts they don't much like. Brown also needs their support for temporary tax increases he wants to have voters pass on the ballot.
Legally, Brown, by dropping the suit, removes the risk of a loss that could restrict his power. And in so doing, he keeps the option of reviving Schwarzenegger's bust-them-back-to-minimum-wage gambit in the future, if public employees don't give him what they want. That preserves his budgetary flexibility and power.
And as a budget matter, having the power doesn't produce savings in and of itself, since any cut to the minimum wage is temporary. State workers would be entitled to back pay once a particular budget standoff is over.
In other words, by playing politics and avoiding a possible legal defeat now, he creates leverage for himself in the current budget battle -- and in future battles.


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Retro recipe: No Bake Cheesecake
Over the last 30 days, searches for "no bake cheesecake" on Yahoo.com have spiked 438 percent, says Yahoo web trend expert Carolyn Clark.
Who knows why, but it seems that people have been trying to avoid baking their cheesecakes for decades. Here's a recipe from deep in the Post's archives, circa 1972.
No-Bake Cheesecake
From legendary Denver Post food editor Helen Dollaghan's Sept. 17, 1972 recipe for No-Bake Cheesecake (a slight misnomer, as the crust is baked, but you could use storebought) – still delicious after all these years. Serves 9.
16 single graham crackers, finely crushed
3 tablespoons melted butter or margarine
2 tablespoons sugar
1 can (13 ounces) evaporated milk
1 package (3 ounces) lemon gelatin
1 cup boiling water
1 package (8 ounces) cream cheese, softened
1 cup sugar
1 teaspoon vanilla
Raspberries, strawberries or other (fresh or frozen) fruit of your
choice, sweetened to taste
Crust: Combine all ingredients, mixing well. Pat mixture evenly on
bottom of square pan (8 or 9 inch size). Bake in oven preheated to
375 degrees until lightly brown. Chill.
Filling: Put evaporated milk in shallow pan, and freeze until ice
crystals form around the edges. Dissolve gelatin in boiling water.
Chill until slightly thickened. Beat gelatin until foamy with
electric mixer on medium speed. Add evaporated milk. Beat until
very fluffy. Cut cheese in small pieces and gradually add to
gelatin mixture. Beat until smooth. Add sugar and vanilla. Beat
until sugar dissolves. Pour filling onto crust. Refrigerate until
firm. Cut in squares. Top with raspberries or other fruit.


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Discover the flavour adventure of the world's most famous jelly bean. Jelly Belly beans expand the flavour horizons with the largest collection of flavours on the planet, each a delicious delight to the taste buds. The Original Gourmet Jelly Bean®.
A wild collection dares you to compare some of our tastiest flavours with our craziest ones. Toothpaste? Moldy Cheese? With these flavours in disguise, you never know which one you will taste!
Bursting with natural flavours and free from artificial colours, the finest pectin jell confections delight the taste buds.
Hello Kitty's favourite red, pink and white Jelly Belly jelly bean flavours create her personal mix and she keeps them in her own Hello Kitty candy dishes. Our Hello Kitty® Collection – a sweet treat for any fashionista!


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When I first spotted this T-Shirt I broke down laughing at its brilliance! It's pure awesome. Designed by The Beardly, this beard measuring T-Shirt does exactly as advertised. It provides acceptable discriptors based on beard length. The discriptors vary from Manly to Civil War Generaly to Wizardly to Beardly. It's so simple and so smart and the perfect companion to any beard heavy manly MAN.
The Beard Measuring T-Shirt is available now for $23.99.


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WASHINGTON, Feb. 26 (UPI) -- Former Sen. Chuck Hagel Tuesday won Senate confirmation to be the new U.S. defense secretary.
The Senate voted 58-41 to approve Hagel after earlier voting 71-27 to end a filibuster that had been blocking the final up-or-down vote.
Sen. Ted Cruz, R-Texas, the main opponent to President Obama's nominee, indicated two weeks ago Hagel might have given still-undisclosed speeches to "extreme or radical groups" or received money from foreign sources or defense contractors from 2008 to 2010.
Senate Armed Services Committee Chairman Carl Levin, D-Mich., debunked Cruz's second accusation, saying Hagel complied with the committee's financial disclosure requirements and deserved to be confirmed as successor to Leon Panetta.
Sen. John Cornyn, R-Texas, said before the vote that he didn't think Hagel was up to the job and called his worldview "dangerously misguided," The Washington Post reported.
"I don't think we want a secretary of defense that has to learn on the job," Cronyn said.
But Senate Majority Leader Harry Reid of Nevada said Hagel had emerged from the nominating process with his reputation intact despite the GOP criticism and filibuster.
"Twelve days later, Senator Hagel's exemplary record of service to his country remains untarnished," Reid said on the Senate floor before the vote.
"Senate Republicans have delayed for the better part of two weeks for one reason and one reason only: partisanship."
Last week 15 GOP senators asked Obama to pull Hagel's nomination. However, NBC News said, it since has become evident Republicans lacked the votes to further delay Hagel's confirmation by extended debate or filibuster.
Hagel turned against the GOP by campaigning for Democratic Senate candidate Bob Kerrey in Nebraska last year. He also criticized President George W. Bush after the Iraq war became unpopular in 2006.
His appearance before the Armed Services Committee was lackluster, with Sen. John McCain, R-Ariz., calling it "the most unimpressive performance that I have seen in watching many nominees who came before the committee."


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We're Remodeling funny doormat
Regular price
Sale price
Don't take yourself too seriously. Get a welcome mat that will show off your sense of humor. We promise it'll generate a reaction from your guests that you don't want to miss! Made with brown coir matting, this outdoor welcome mat is designed to clean your shoes before entering your home.
- Polyvinyl chloride (PVC) backing to avoid slippage
- Water repellant backing
- Tough against dirt
- Eco-friendly
- 23.6" wide x 15.75" long x 0.5" height
- Step 1: Shake me out to remove loose debris
- Step 2: Rub my belly with baking soda
- Step 3: Rinse me with a hose
- Step 4: Hang me out to dry so I can sunbathe
Shipping and Return Policy
Free shipping to the United States! Orders placed before 12pm EST each business day generally ship the same day. You can expect to receive your order in 3-5 business days via standard ground shipping. Please note that delivery estimates are based on averages, and your order may be delivered faster or slower.
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This fabric is ideal for curtain making, light upholstery, bunting and much more! Printed here in the UK onto a wonderful quality 238gsm linen/cotton, printed width 140cm minimum (joining at 137cm).
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When Sean Carroll was a graduate student at Tufts School of Medicine in Boston, he found himself seduced by spectacular new studies of the humble fruit fly. That work, which eventually won a Nobel Prize for its principals, showed that modifying a single gene during a fly's embryonic development could transform the insect's body plan: Instead of becoming an antenna, a body extension could develop into a leg. Carroll continued to study these genes and, some years later, found that they were not restricted to fruit flies; they turned out to be part of a master tool kit that sculpts the body structures of all animals, ranging from humans to nematode worms.
The discovery of this small set of universal body-building genes gave Carroll and others a fresh way to explore the inner workings of evolution. By observing how the genes changed during the course of embryonic development, scientists could track the emergence of a novel physical trait, the first step toward the creation of a new species. For the first time, researchers had direct access to the machinery of evolution and could actually watch it in the act. A new science, known as evolutionary developmental biology, or evo devo, was born.
One of the great triumphs of modern evolutionary science, evo devo addresses many of the key questions that were unanswerable when Charles Darwin published On the Origin of Species in 1859, and Carroll has become a leader in this nascent field. Now a professor of molecular biology and genetics at the University of Wisconsin, he continues to decode the genes that control life's physical forms and to explore how mutations in those genes drive evolutionary change. These days, Carroll also devotes increasing energy to telling the public about his field's remarkable discoveries through a series of books—Endless Forms Most Beautiful, The Making of the Fittest, and the brand-new Remarkable Creatures. He spoke with DISCOVER senior editor Pamela Weintraub about what his work has taught him about Darwin, the nature of evolution, and how life really works.
It has been 150 years since Charles Darwin proposed his theory of evolution in On the Origin of Species, yet in some ways the concept of evolution seems more controversial than ever today. Why do you think that is? It is a cultural issue, not a scientific one. On the science side our confidence grows yearly because we see independent lines of evidence converge. What we've learned from the fossil record is confirmed by the DNA record and confirmed again by embryology. But people have been raised to disbelieve evolution and to hold other ideas more precious than this knowledge. At the same time, we routinely rely on DNA to convict and exonerate criminals. We rely on DNA science for things like paternity. We rely on DNA science in the clinic to weigh our disease risks or maybe even to look at prognoses for things like cancer. DNA science surrounds us, but in this one realm we seem unwilling to accept its facts. Juries are willing to put people to death based upon the variations in DNA, but they're not willing to understand the mechanism that creates that variation and shapes what makes humans different from other things. It's a blindness. I think this is a phase that we'll eventually get through. Other countries have come to peace with DNA. I don't know how many decades or centuries it's going to take us.
In your new book, Remarkable Creatures, you relate how Darwin arrived at his theory of evolution. Can you connect the dots? As a college student Darwin collected beetles. He was looking for more opportunities to collect when there came this opportunity to be a naturalist on the British ship the HMS Beagle. It was seductive. He could go to faraway places—visit the tropics, places of incredible richness of life relative to cold, damp, gray England. It was difficult to persuade his father to allow him to go—he was just 22—but he got the chance. Two stops in this five-year journey were pivotal. The first came early in the voyage when he arrived on the coast of Argentina and unearthed fossils of many species, including some unknown to science—for instance, fossils of giant, extinct sloths that had been enormous compared with the living sloths he saw in the South American forests. So it planted the seed in his mind that life had changed.
Then Darwin got to the Galápagos Islands. He went from island to island collecting birds—mockingbirds and then finches—and realized that even when the birds appeared to be similar, on each island they were slightly different. After he left the Galápagos, on his way home to England, the lightbulb went on. He realized that if these birds lived on such similar islands but were slightly different from one another, there could be just one explanation: They had started out as a single species, but over time and with separation they had drifted apart and changed.
This insight was widely regarded as heresy, but why? The prevailing idea was called special creation: that every species was created by a supernatural power and put in place on the earth for a specified role in a specified time by a completely mysterious process. It wasn't open to natural science. Instead, Darwin said no, species are changeable, and the introduction of new species is a completely natural process that follows natural laws just the way physics does. A fundamental aspect of human existence has been to ask how we got here. Evolution is the big answer to that big question. Obviously there are alternative answers that have prevailed for a very long time, but evolution has replaced a supernatural explanation of human origins with a naturalistic one.
Is that why Darwin waited more than 20 years to publish his theory of evolution? Darwin was a pretty insecure 22-year-old when he boarded the ship. As these thoughts started to occur to him by the time he was about 27, he was just getting his feet under himself back in England. He realized what these thoughts meant, but he was just being accepted into scientific circles, just getting a lot of attaboys. Why risk that? This was not a time to challenge the establishment. You have to look at Darwin the human being to understand why he would not spill the beans.
What piqued your own interest in evolution? As a kid, I was fascinated by zebras and giraffes and leopards. I kept snakes, and I loved their color patterns. As I got older I asked deeper questions—mainly, how are pattern and form generated? One of the most spectacular pageants on earth involves a complex creature developing from a single fertilized egg. Anyone who's a parent is still amazed that it works. When I was a graduate student, we could watch this happen, but we didn't understand the mechanics. What was going on inside that would put limbs in the right place, put eyes in the right place, carve the circulatory system and the backbone? It was an irresistible mystery, made even more irresistible with the realization that what makes a snake different from a lizard, what makes a zebra different from a giraffe, are changes within that developmental process. Understanding development was a passport to two fundamental questions: How does a complex creature form from an egg, and how have different types of creatures evolved?
These seem like two very disparate ideas: the embryonic development of a single specimen and the evolution of a whole species. How did they get connected? At first paleontologists were studying evolution on vast timescales through fossils. Then geneticists came on the scene, and they were studying small-scale differences within species based on mutations in genes. What has been called the modern synthesis of the two fields emerged in the 1940s with the idea that the sorts of genetic differences you could observe in populations, right out your window, when compounded and extrapolated over vast periods of time, could account for the large-scale changes we see in the fossil record. So the modern synthesis was a harmonization of those two scales.
But the modern synthesis did not explain evolution in full. It was still just a theory. Where was the empirical evidence? Darwin's theory of descent was a black box. You could not see exactly what kinds of changes were taking place to account for the differences in forms. But the study of embryonic development has allowed us to peer into the machinery of making these creatures. We can study their DNA text and their developing embryos and ask, where do the differences arise? That gave us the empirical data for the theory. You can't necessarily see the change happening in the adult, but you can see that if you change that nucleic acid base right there in that gene, at that particular point in embryonic development, that animal is darker. If you change those three bases over there, that limb is longer. This is the fundamental basis of evolution: changes in DNA. By experimenting with it and visualizing it all the way up the ladder of differences, we now understand that the modern synthesis is correct.
You've said evolution is like compounding interest. How so? Just like a good money market account, evolution works through incremental change. If variants within a species provide an advantage, no matter how slight, then that form, that capacity, will be favored. If evolving spots on wings makes you more attractive to mates or more evasive to predators, those patterns will dominate. Those varieties will have more offspring. Added up over centuries, millennia, and longer periods of time, natural selection—the competition that takes place in nature between variant forms—is powerful enough to forge all the changes that we've seen on the face of the earth.
It is hard for most people to wrap their brains around such vast stretches of time. A century ago, Teddy Roosevelt was president and cars were barely in use. That seems like an unimaginable amount of time ago, but biologically and geologically speaking, it was a split second. A million years is just a fraction of the time that upright hominids have had to evolve. It takes time for sea levels to rise, for rivers to cut their course. As temperatures change, as rain forests grow up or deserts emerge, the creatures that live in these regions are adapting and changing too.
You call the combination of evolution and embryonic development evo devo. What is that, exactly? It is just shorthand for "evolutionary developmental biology," a mini-syllabic description of this field that's concerned with the evolution of development. It's related probably to Devo, the new-wave band of the early 1980s—those were the guys who played with dog dishes on their heads. Before then you could describe evolution as change over time, but we did not have any grip on that process until the 1980s.
And that's when you entered the scene? Right. I was in graduate school doing research in immunology at Tufts University in Boston. I would just hop on the subway and go to seminars at three or four different schools. It's stimulation, right? It's hard to know how all the dots got connected, but I kept hearing that things were not well understood in evolution and things were not well understood in development, and I started thinking: How can I get at the meat? I was looking around for insights when I came across the very thin literature on the genes that sculpt fruit fly bodies, including the study of spectacular mutants. In these mutants, or Frankenflies, a single gene could put legs on the head in place of antennae. Other single-gene mutations gave the flies an extra set of wings or removed its eyes or wings completely. The fact that single-gene mutations could have such dramatic effects raised the question: What were these genes, and what were they meant to do? The quest was to figure out how these genes sculpted the fruit fly body form.
You saw the fruit fly as a window into evolution and development. How did you make the connection? It was not an obvious call, because the expectation was that fruit flies didn't have anything to do with the development of furry creatures. But in 1983 I found a laboratory where I could do the work, with Matt Scott at the University of Colorado at Boulder. Just as we were getting started, it became clear from our research and others' that these body-building genes were not restricted to fruit flies; they were shared throughout the animal kingdom. It was a real jolt. All of a sudden we could do deep experiments at the most fundamental level to understand how form actually evolved.
So scientists were seeing the same master genes at work in many different species? Yes. One shocking discovery was the relationship between our eyes and bug eyes. You wouldn't think they had anything in common, right? Bug eyes, with 800 facets, work by different optical principles than human eyes. For almost a century and a half, biologists thought that they had evolved independently, from scratch, and that eyes had been invented many times in the animal kingdom by completely different means—different recipes in different groups of animals. We have now discovered that these eyes are formed by what is recognizable as the same gene, even though those animals have been evolving separately for 500 million years. When we took the mouse version of this gene—the same gene we find in the human—and put it in the fly and tweaked it, we induced fly eye tissue.
Our team showed that the same common gene is critical to building limbs in humans and fruit flies. It turns out that this gene is critical to building virtually everything that sticks out of the body: antennae, legs, horns, whatever. These kinds of experiments shattered our preconceptions and forced people to think differently. Beneath these extremely diverse exteriors was a deeply shared common genetic tool kit. If I had five minutes with Charles Darwin, I'd start right there. It would blow his mind.
Clearly we have entered the age of experimental Darwinism. What are the experiments like, specifically? We look at lots of species to figure out the ancestral form of a particular molecule. We can reconstruct that ancestral molecule and then retrace the steps that must have taken place to forge the new forms and functions we see today. If you think that the difference between two species involves changes in certain genes, you can swap those genes between the species. We're doing those experiments trait by trait. There's a powerful set of experiments that people have done on vision. Lots of animals differ in the parts of the color spectrum that they see best because of how they are tuned to their environments —whether they live in the deep sea or in caves, whether they mostly go out in the day or at night, or whether they're trying to pick up ultraviolet patterns on flowers or on prey. Sight is really important in helping animals live, and since animals live in lots of different habitats, vision has evolved a lot.
Experiments that look at these changes are very doable in the lab. You can swap genes and change the retinal proteins that detect light. Then you can make very clear predictions about what certain changes mean and verify those things experimentally. For example, mice have been given an extra color vision gene in the lab, and it has been shown that the protein manufactured by that gene expands the scope of their vision by enhancing their ability to see longer-wavelength light without any other changes in the brain.
Can we apply these discoveries to the human realm? We now know that the human genome and the chimp genome differ by only about 1 percent. Yet our bodies and brains are so different. How can we be so different from other primates if our genes are so much the same? How did we get the dexterity in our hands? How do we walk upright? How are we able to hold this conversation? How did we get big brains? Once you identify the meaningful functional changes that have taken place between us and chimps, you realize that pretty big differences in anatomy and behavior can result from a small degree of genetic divergence. Evo devo has given us the tools to explore this mystery: The same genes are being regulated and then used in a different way. Something is happening a little earlier or in another place or is staying on a little bit longer. These are the time and space dimensions of development. It's like choreography. You've got the same dancers, but the ballet is different based on different cues.
In your book Endless Forms Most Beautiful, you refer to the Cambrian explosion, a time when a vast number of new life-forms appeared at nearly the same time. Evolutionary skeptics often point to this kind of abrupt shift—doesn't such rapid change contradict your description of a single master tool kit and slow evolution over long stretches of time? Prior to about 543 million years ago, you saw things like jellyfish and spongelike creatures, but you didn't see bilateral creatures: worms and trilobites and things like this. Then in the Cambrian explosion, large and complex animal forms erupted. These forms in the Cambrian represent a lot of the major divisions of the animal kingdom we see today. The Cambrian explosion looks abrupt in the fossil record, but the surprising message from evo devo is that all the genes for building big, complex animal bodies long predated the appearance of those bodies. Most of what was needed to create this incredible complexity already existed. The genes were expressed prior to the Cambrian in those more modest, soft-bodied creatures, but they had fewer jobs to do. Complexity evolved by expanding the uses of these genes rather than inventing lots more of them.
It makes you wonder what kind of potential is just waiting to burst out today. Dinosaurs were the dominant vertebrates right up until the end of the Cretaceous. Mammals existed, but they were smaller, carving lifestyles out of the dinosaurs' way. Take out the dinosaurs and in 10 or 15 million years mammals had evolved into all sorts of large forms and dominated terrestrial ecosystems. When genetic potential met ecological opportunity, you got elephants and bison and giraffes. Think about ecology as corking the bottle; take the cork out and things explode.
You mention in your book The Making of the Fittestthat every species contains fossil genes. These are remnants that are no longer used, and the integrity of the genetic text starts to erode. One of my favorite stories concerns the ice fish of Bouvet Island. These creatures live in the cold waters of the Antarctic. They are the only vertebrates without red blood cells to carry oxygen to nourish their tissues. If you look at the genes for hemoglobin, the oxygen-carrying proteins in red blood, one of those genes is completely gone and another is a broken remnant, rotting away. From this we understand that the ancestors of these fish had red blood, but these guys have left that red-blooded lifestyle behind.
The explanation is ecological. The ice fish are living in this extremely cold water, and it may well be that red blood cells are really hard to pump around capillaries in such cold water. Instead, the fish have larger gills and pretty much a scaleless skin. So they're just getting their oxygen passively from the surrounding ocean water. They've abandoned a way of life that has nourished vertebrates for some 500 million years. As for us, humans have junked about 800 genes in the course of our evolution from mammalian and earlier ancestors going back millions of years. Who knows, those lost genes might be useful to us 1,000 years from now, but there's no way to preserve them. I guess we could always try to engineer some things back in.
By contrast, you've said that some genes are immortal. These genes date back to the early origin of life on the planet, and they're so essential that their text has been preserved for more than 3 billion years. They're involved in very fundamental ways with the decoding of the genetic machinery shared among all organisms. Without these genes you couldn't express your genetic information and produce the proteins you need to live.
You've presented an avalanche of irrefutable evidence, yet opponents of evolution seem to refute it all. How do you respond?
You can hear me almost chuckling, because it's not reasonable, it's not rational, and as the years click by, it's ever more preposterous, but people still stick to their guns.
Is there anything we can do to help persuade the skeptical public to accept the evolutionary way of looking at life? Seriously, teach evolution as a core theme in science from the early grades. The universe changes, the earth changes, and life changes with the evolving earth.
Where do you see evolutionary biology going next? Today we're in a second golden age. We're not collecting the menagerie of critters that Darwin did or hauling them back to a museum. Instead, we're collecting the genetic recipes of creatures across the planet and trying to figure out how they came to be. We're looking right into the text of evolution, and even into the text of extinct creatures like woolly mammoths and Neanderthals, and we're asking what made them similar to or different from elephants or from us.
A third golden age will come when we understand life beyond earth. How many times has life evolved, and how many origins have there been? Has life moved from planet to planet? Is the chemistry of extraterrestrial life different from that of life on earth? This will be difficult work, but we have to look ahead. Finding life elsewhere in the universe would bring a scientific revolution as big as any we've ever had.


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Bear Back: Statue returns under cover of darkness in Oneida
ONEIDA >> A bear statue stolen from the Carinci family's Sconondoa Road lawn last Friday mysteriously reappeared early Wednesday.
Army "Little Army" Carinci said he's glad the statue was returned and will take a few extra precautions to protect the popular decoration.
Carinci said he woke up to find the bear had been returned Wednesday morning, sometime before 6 a.m. After dressing him up in his best trout fishing garb, Carinci secured the bear to a tree using a length of chain and a lock.
"It was just something we did to make our neighbors happy," Carinci said. "He was ours, but we had him out there for everyone."
Carinci said he and his wife often decorated the bear for holidays and special occasions. At times, other people would ask to dress him up as well. The solid wooden sentinel also stood vigil in military garb for a short time when Lance Cpl. Jeremy S. Lasher's body was returned home.
"I never believed it would come back," Carinci said. "I'm glad that whoever it was had a change of heart after my family reached out."
In addition to the letter to the editor that ran in the Tuesday edition of the Oneida Dispatch, Carinci said his children made postings on Craigslist, Facebook and various other social media asking to have the bear returned.
Carinci had asked the carvers at Yankee Doodle in Canastota to make another one, though now that the previous bear has been returned he hopes they have not already started. A carving of this sort can be expensive, ranging from hundreds to thousands of dollars.
Carinci said he was happy when they found their first bear at a yard sale for only $20 more than five years ago.


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Phase III Results Showed omalizumab Significantly Reduced Disease Severity in Patients with a Chroni
Phase III Results Showed omalizumab Significantly Reduced Disease Severity in Patients with a Chronic Form of Hives who Failed Standard Therapy
Study Published in NEJM Today and Presented Tomorrow at AAAAI Annual Meeting
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)-- Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced results from a Phase III trial, ASTERIA II, which demonstrated that omalizumab met its primary endpoint in patients with moderate to severe chronic idiopathic urticaria (CIU), who remained symptomatic despite treatment with approved H1 antihistamine doses1. The data were published today in the New England Journal of Medicine and will be presented tomorrow at the American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting in San Antonio, TX.
CIU, also referred to as chronic spontaneous urticaria (CSU) outside the United States, is a skin condition characterized by red, swollen, itchy hives on the skin2,3 and is diagnosed when hives spontaneously present and reoccur for more than six weeks2. Angioedema, or swelling of the deep layers of skin, is common in patients with CIU4,5.At any given time, the prevalence of CIU is approximately 0.5 percent to 1 percent worldwide4,5. Currently, H1 antihistamines are the only approved therapy for patients suffering from CIU.
"We are pleased with the results of the ASTERIA II study, as people with chronic idiopathic urticaria unresponsive to H1 antihistamines need new treatment options," said Hal Barron, M.D., chief medical officer and head of Global Product Development. "We look forward to sharing the results of two additional Phase III omalizumab CIU studies at upcoming medical meetings this year."
Genentech plans to file a supplemental biologics license application (sBLA) with the U.S. Food and Drug Administration (FDA) for omalizumab in CIU later this year. The ASTERIA II data are the first Phase III results to be presented from the omalizumab clinical trial program in CIU, which also includes two additional Phase III studies (GLACIAL and ASTERIA I) investigating the efficacy and safety profile of omalizumab over 24-week treatment duration.
Study Results
The primary endpoint was measured using a 21-point scale known as a weekly Itch Severity Score (ISS)1. Patients used an electronic diary to report their daily itch severity (0=none, 1=mild, 2=moderate, and 3=severe), with potential weekly scores ranging from 0-211. Three dose groups were chosen and compared to a placebo group. The study met its primary endpoint in two of the three dose groups studied, showing that omalizumab administered every four weeks led to significant improvement in the mean weekly ISS from baseline (approximately 14 in all treatment groups) at Week 12.
The improvements were 8.1 to 9.8 in two of the dose groups, respectively compared to a 5.1 improvement in patients on placebo. One of the dose groups studied did not demonstrate statistical significance compared to placebo for the primary endpoint. The incidence and severity of adverse events (AEs) was similar across treatment groups1.
All eight pre-specified secondary endpoints in the ASTERIA II trial were met for the two dose groups that met the primary endpoint, except for one dose group that did not show a significant difference from placebo in the proportion of angioedema-free days from Week 4 to Week 12 of therapy1.Patient response, as measured by the median time to Minimally Important Difference (MID) in itch severity score, a secondary endpoint, occurred at week one with omalizumab compared with four weeks in the placebo group1.
Nine patients experienced serious adverse events (SAEs): two patients in the placebo group reported SAEs of pneumonia and hemorrhoids; in the three omalizumab dose groups, seven patients reported SAEs of angioedema (two), urticaria, idiopathic urticaria (two), melanoma in situ (onset stage of skin cancer), nephrolithiasis (kidney stones), tonsillectomy, and melena (black blood in stool). No SAEs were suspected to be caused by the study drug or led to withdrawal from treatment1. No deaths were reported during the study1.
About ASTERIA II
ASTERIA II was a Phase III, global, multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety profile of omalizumab compared with placebo in 323 patients 12 to 75 years of age with moderate to severe CIU who were receiving H1 antihistamine therapy at approved doses. Patients were randomized to three omalizumab dose groups or placebo, given every four weeks, for a total of three doses within a 12-week treatment period1.
In addition to the primary endpoint, the study had eight pre-specified secondary endpoints: Change from baseline in weekly urticaria activity score (UAS7) at Week 12; Change from baseline in weekly number of hives score at Week 12; Time to MID (MID=5) response in weekly itch severity score by Week 12; Proportion of patients with UAS7 ≤ 6 at Week 12; Change from baseline in overall dermatology life quality index (DLQI) at Week 12; Proportion of angioedema-free days from Week 4 to Week 12; Proportion of patients with MID response in weekly itch at Week 12; Change from baseline in size of largest hives score at Week 12.
Omalizumab is jointly developed by Genentech under an agreement with Novartis Pharma AG and is co-marketed in the United States with Novartis Pharmaceuticals Corporation.
About XOLAIR
XOLAIR is not indicated for Chronic Idiopathic Urticaria.
XOLAIR® (omalizumab) for subcutaneous use is an injectable, prescription medicine for patients 12 years of age and older. It is for patients with moderate to severe persistent allergic asthma caused by year-round allergens in the air. A skin or blood test is done to see if you have allergic asthma. XOLAIR is for patients who are not controlled by asthma medicines called inhaled steroids.
XOLAIR helps reduce the number of asthma attacks in people with allergic asthma who still have asthma symptoms even though they are taking inhaled steroids.
Important Limitations of Use
- XOLAIR has not been proven to work in other allergic conditions.
- XOLAIR is not a rescue medicine and should not be used to treat sudden asthma attacks.
- XOLAIR should not be used in children under 12 years of age.
XOLAIR should always be injected in a doctor's office. Patients should read the Medication Guide before starting XOLAIR treatment and before each and every treatment.
A severe allergic reaction called anaphylaxis has happened in some patients after they received XOLAIR. Anaphylaxis is a life-threatening condition and can lead to death. Patients must seek emergency medical treatment right away if symptoms occur.
Signs and symptoms of anaphylaxis include:
- wheezing, shortness of breath, cough, chest tightness, or trouble breathing
- low blood pressure, dizziness, fainting, rapid or weak heartbeat, anxiety, or feeling of "impending doom"
- flushing, itching, hives, or feeling warm
- swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing
Anaphylaxis from XOLAIR can happen:
- right after receiving a XOLAIR injection or hours later
- after any XOLAIR injection. Anaphylaxis has occurred after the first XOLAIR injection or after many XOLAIR injections.
A patient's healthcare provider should watch the patient for some time in the office for signs or symptoms of anaphylaxis after injecting XOLAIR. If patients have signs or symptoms of anaphylaxis, they must tell their healthcare provider right away.
Patients must not receive XOLAIR if they have ever had an allergic reaction to a XOLAIR injection. Patients should not use XOLAIR if they are allergic to any of its ingredients.
In clinical studies, a variety of cancer types, including breast, skin, prostate, and parotid (a type of salivary gland), were reported in more patients who received XOLAIR than in patients who did not receive XOLAIR.
XOLAIR is not a rescue medicine and should not be used to treat sudden asthma attacks.
XOLAIR is not a substitute for the medicines patients are already taking. Patients must not change or stop taking any of their other asthma medicines unless their doctor tells them to do so.
Some patients on XOLAIR may have an abnormal increase in eosinophils (a type of white blood cell) in the blood or tissues, sometimes causing an inflammation of blood vessels, which can lead to rash, worsening of respiratory symptoms, heart trouble, and/or nerve pain and weakness.
Joint inflammation or pain, rash, fever, and swollen lymph nodes have been seen in some patients taking XOLAIR after the first or subsequent injections. Patients should talk to their doctor if they have experienced any of these signs and symptoms.
The most commonly seen side effects occurring more frequently in patients receiving XOLAIR than in patients who received placebo (an injection with no active medicine) were joint pain, pain (general), leg pain, tiredness (fatigue), dizziness, fracture, arm pain, itching, inflammation of the skin, and earache.
In asthma studies, the most common side effects in patients, who either needed to stop XOLAIR or needed medical attention, were injection site reaction, viral infections, upper respiratory tract infection, sinusitis, headache, and sore throat. These side effects were seen at similar rates in XOLAIR-treated patients as in patients that did not receive XOLAIR.
There are other possible side effects with XOLAIR. Patients should talk to their doctor for more information and if they have any questions about their treatment.
XOLAIR has not been studied in pregnant women. Pregnant women exposed to XOLAIR are encouraged to enroll in the XOLAIR Pregnancy Exposure Registry. Patients can get more information by calling 1-866-4XOLAIR (1-866-496-5247) or by speaking with their doctor.
Please visit http://www.xolair.com for the full Prescribing Information, including Boxed WARNINGS and Medication Guide for additional important safety information.
About Genentech Access Solutions
Genentech is committed to people having access to our medicines. Genentech Access Solutions is a team of more than 350 Genentech employees who help those who need our medicines. Our knowledgeable and experienced Specialists can help patients and medical practices navigate the access and reimbursement process and provide assistance to eligible patients in the United States who do not have insurance coverage or who cannot afford their out-of-pocket co-pay costs. For more information, please visit http://www.GenentechAccessSolutions.com.
About Genentech
Founded more than 30 years ago, Genentech is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. The company, a member of the Roche Group, has headquarters in South San Francisco, California. For additional information about the company, please visit http://www.gene.com.
1 Maurer M, Rosén K, Hsieh HJ, et al. Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. NEJM 2013; DOI: 10.1056/NEJMoa1215372
2 Asthma and Allergy Foundation of America (AAFA) website. "Chronic Urticaria (Hives)." http://www.aafa.org/display.cfm?id=9⊂=23&cont=328. Accessed November 14, 2012.
3 American Academy of Allergy Asthma & Immunology (AAAAI) website. "Skin Allergy Overview." http://www.aaaai.org/conditions-and-treatments/allergies/skin-allergy.aspx. Accessed November 14, 2012.
4 Maurer M, Weller K, Bindslev-Jensen C, et al. Unmet clinical needs in chronic spontaneous urticaria. A GA2LEN task force report. Allergy 2011; 66: 317-330.
5 Bernstein J, Moellman J. Emerging concepts in the diagnosis and treatment of patients with undifferentiated angioedema. Int J Emerg Med 2012. 5: 39.
Chris Vancheri, 650-467-6800
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One of the clients at our clinic is a photographer and offered to set up a shoot at our clinic for our pets and our client's pets. Here are a few from the other day... Seth is a complete goon!
One of the first taken, Seth was busy smelling the set and LiLo thought she was being beaten.
Seth's lower incisors are showing and it makes me laugh!
When the treats came out they were able to hold still a little.
The photographer started making funny noises and Seth just wanted to say hi! LiLo is the good one who doesn't get up until you tell her to :p


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Sparkler Filters Inc.® has been manufacturing high quality filtration products for over three quarters of a century. Many used equipment dealers throughout the world offer Sparkler Filters® which have been acquired on the open market from a variety of sources. Sparkler® is offering 'buyer assistance' to prospective buyers of used filters.
You may be considering the purchase of a used filter. Used filters are sold where is and as is. Often times the only information offered by the seller of the used equipment are the serial number and perhaps the type of construction material used to fabricate the filter. These filters may pass through several hands being sold and resold before they find their way to you. The purchase history is often obscured.
Quite often the required ASME stamp and/or National Board Number may be missing. To place a pressure rated vessel into service without an ASME U Stamp and National Board Number is a violation of many states laws and may subject the owner of the filter to numerous liabilities and severe penalties or fines. Insurance policy renewals may be affected.
The age of the filter is often misstated or even unknown. As an example I received a request for parts for a used filter that had been built in 1947. The particular design was obsolete and I could not furnish parts because our file did not contain adequate drawings. The customer was stuck with an old filter best used as a door stop.
The prospective buyer of a used filter, especially if he has no prior filtration experience, may be purchasing a product that will require thousands of dollars to repair it. It also leaves the prospective buyer with few options for service and technical assistance.
We at Sparkler Filters® would like to offer our assistance with your used filter purchase. Sparkler Filters Inc.® offers a program to take some of the risk out of purchasing a used filter. Sparkler® will conduct a virtual inspection of the filter from photographs submitted by you or the dealer of the tank, cover and cartridge.
The following photographs must be provided-
- Tank exterior with cover in place and swing bolted
- Interior of tank and cover with cartridge removed
- Cartridge photo taken as a side view of the cartridge
- Top of the assembled cartridge bundle showing the top plate clearly
*These photographs should be high quality, well lighted and capture a good representation of the filter. Poor quality photographs will prevent us from making a meaningful virtual inspection.
If the virtual inspection shows a possibility of a viable filter choice then you may elect to have the filter shipped to us for an in-house inspection. The virtual inspection and in-house inspection can also be applied towards re-certification. Re-certification allows Sparkler® to provide you with additional documentation and support.
*The filter must arrive at our facility pre-cleaned and ready for inspection. Should a dirty filter arrive we reserve the right to refuse inspection of the filter until it has been properly cleaned and deemed contaminate free, or a cleaning charge assessed dependent upon initial observation. In cases of severe contamination Sparkler® reserves the right to refuse inspection and it will be shipped to the customer freight collect.
*Under all conditions the person ordering the filter inspection would be responsible for freight both ways.
Once the filter is deemed clean and contaminant free we will inspect the filter and provide a written inspection report suggesting any repairs and replacement parts necessary to refurbish the filter to operate safely and effectively in your application.


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17 September 2013 at 7.38pm | 10 Comments
The Royal Opera House Live Cinema Season 2013/14 opens tonight with a broadcast of Puccini's classic Turandot.
Hot on the heels of the success of the 2012/13 Season, which attracted audiences of up to 40,000, the Live Cinema Season 2013/14 has expanded to more than 1,000 cinemas across 40 countries, and features an unprecedented five Royal Opera and five Royal Ballet productions.
'In the cinema you feel like you have the best seat in the house,' said Director of Music Antonio Pappano ahead of the live screening of Turandot. 'The cinema experience brings you closer: you see the sweat and expression on the faces of some of the finest singers and dancers on stage. I am very much looking forward to this evening, along with the other 9,999 sites sharing in this wonderful experience.'
Carlos Acosta, Thiago Soares, Marianela Nuñez and Bryan Hymel at the ROH Cinema Season 2013/14 launch © ROH
Following tonight's screening of Turandot, Carlos Acosta's hotly anticipated new production of Don Quixote (in which Carlos and Marianela Nuñez dance the lead roles) will be screened live on 16 October. This is followed on 4 November by Stefan Herheim's new production of Verdi's Les Vêpres siciliennes, featuring a stellar cast that includes Bryan Hymel, Marina Poplavskaya, Erwin Schrott and Michael Volle.
Bryan Hymel will sing the role of Henri for the live cinema relay of Les Vêpres siciliennes. 'When performing in a live cinema relay, it is forever in your mind that it's not just the people in the auditorium you are performing for, but some twenty to thirty thousand people across the globe,' he says. 'The energy of it being live is just a great new experience as you have to be so mindful of the details - the eyes and face. In the cinema, you honestly have the best seat in the house.'
Other productions to be screened live include Christmas favourite The Nutcracker, Stephen Langridge's new production of Parsifal, Peter Wright's Giselle and Kasper Holten's new production of Mozart's Don Giovanni.
Since 2009, when the Royal Opera House broadcast in just 120 sites in 12 countries, ROH Live Cinema has expanded rapidly.
'We've been on a tremendous journey since the Live Cinema Season launched,' continues Antonio Pappano. 'Last season, over 32,000 people watched The Nutcracker: it was the second highest grossing film that night - nestled between The Hobbit and Skyfall'.
Similarly, 35,000 attended the live screening of Nabucco in April 2013, while some 40,000 watched the screenings of Alice's Adventures in Wonderland.
View the full list of productions for the 2013/14 Season and find a cinema near you.


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United Nations chief arrived in Lebanon on Friday for talks on a U.N.-backed tribunal probing the death of the country's former leader and the ongoing bloodshed in neighboring Syria.
The U.N. secretary-general is also expected to discuss attacks against U.N. peacekeepers in southern Lebanon and the weapons stockpile of militant group Hezbollah. Mr. Ban is scheduled to meet with Lebanese President Michel Suleiman, Prime Minister Najib Mikati and leaders of parliament.
In a recent interview with Arabic daily an-Nahar, Mr. Ban repeated his calls for Hezbollah to disarm. Hezbollah is the only Lebanese faction that has refused to lay down their arms following the 1975-1990 civil war.
Ahead of Mr. Ban's arrival, a Hezbollah official made clear that the U.N. chief is not welcome in Beirut.
At the top of Mr. Ban's agenda will be discussion on the Hague-based tribunal investigating the 2005 assassination of former Prime Minister Rafik Hariri. Four members of Hezbollah have been accused in the bombing that killed Mr. Hariri and 22 others in the Lebanese capital.
Hezbollah, Lebanon's strongest political faction, has denied involvement in the slaying and has refused to hand over the four suspects to the Special Tribunal for Lebanon.
Mr. Ban said he would soon decide whether to renew the tribunal's mandate that is due to expire at the end of February.
The U.N. chief made a repeated appeal to Syrian President Bashar al-Assad to stop the violent crackdown on protesters during the an-Nahar interview. He also urged the international community to come together to adopt a united stand on the uprising in Syria.
Some information for this report was provided by AFP and Reuters.
UN Chief Arrives in Lebanon to Talk on Hezbollah and Syria
United Nations chief arrived in Lebanon on Friday for talks on a U.N.-backed tribunal probing the death of the country's former leader and the ongoing bloodshed in neighboring Syria.


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It's been nearly a year since The Lying Game has been on the air, and if you've forgotten what has happened, feat not! Sutton Mercer is here to remind us where we left off before the series returns in January
Has your favorite show been canceled?
In the exclusive video below, Sutton (Alexandra Chando) explains how a journey to find her birth mother led her to her twin sister Emma, whom no one knew about, and their identity swap. But Sutton's motives aren't exactly pure, as we learned in the season finale - she's been secretly scheming with her mom Rebecca (Charisma Carpenter).
Watch below:
Season 2 of The Lying Game premieres on Tuesday, Jan. 8 at 9/8c.
Check out The Lying Game catch-ups from Emma's and Ethan's perspectives at ABCFamily.com.
View original Exclusive Video: Sutton Mercer Catches Viewers Up on The Lying Game at TVGuide.com
Other Links From TVGuide.com
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|Home >> Course Descriptions >> College of Arts and Sciences
|Three semester hours.
|Individual supervision of a project paper, approved by student's advisor, to be undertaken at or near the end of student's classwork. Prerequisite: Permission of instructor.
Home - General Information - Student Services -
Academic Undergraduate Regulations -
Undergraduate Degrees - Academic Graduate Regulations -
Graduate Degrees - Course Descriptions - Faculty -
Appendix A - Appendix B - Appendix C - Appendix D


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Awards include funds for humanities projects in U.S. history and culture
The National Endowment for the Humanities (NEH) today announced the awarding of $25.2 million to 288 successful grant applications nationwide, including many that explore topics in U.S. history and culture. The grants are in four of NEH's program areas--preservation and access, research, education, and public programs.
"Many of these humanities projects will contribute significantly to our citizens' understanding American history and culture," said NEH Chairman Bruce Cole. "It is my pleasure to announce the latest round of NEH grants, including those that support the goals of the Endowment's We the People initiative, for projects that will broaden access to significant documents, support our nation's scholars and teachers, and deepen our understanding of our nation and the world in which we live."
In September 2002, President George W. Bush announced a new NEH initiative called We the People, which included a call for grant applications to explore significant events and themes in our nation's history. This cycle of NEH grants, representing projects in a variety of humanities disciplines, includes many that focus on U.S. history and culture, such as the following:
- Grants to 40 public libraries in 29 states to support a traveling exhibition and related public programs that reexamine President Abraham Lincoln's efforts to abolish slavery during the Civil War;
- A grant to the Bill of Rights Institute in Washington, D.C., to create a teachers' guide, pilot workshop, interactive Web site, and other teaching aids to improve students' knowledge of the contributions of the Founding generation to American democracy;
- A grant to the Maine Humanities Council, Portland, for an exemplary education project that will conduct seminars and develop interactive curricular resources for Maine teachers who will study the work of poet Henry Wadsworth Longfellow and his influence on the American identity;
- A grant to the University of Wisconsin, Madison, for compilation of the fifth volume of the Dictionary of American Regional English;
- A grant to the Illinois State Historical Library, Springfield, for planning statewide book discussions and exhibitions about the cultural and historical significance of the early portion of the Lewis and Clark Expedition;
- A grant to the Historical Society of Western Pennsylvania, Pittsburgh, for an exemplary education project to create print- and Web-based curriculum materials for K-12 teachers relating to the Native American cultures of the eastern United States from the time of contact through the colonial period; and
- A grant to the South Valley Academy, Albuquerque, N.M., for a curriculum enrichment project on World War II and New Mexico's contribution to the war effort.
In this award cycle, institutions and individuals in 42 states, the District of Columbia, and Puerto Rico received grant offers from the National Endowment for the Humanities. A state-by-state listing of grants is available as an Adobe PDF file in the above box.
Programs, total number of projects, and total dollar amounts for grants included in this announcement are as follows:
Preservation and Access (63) $18,703,973
- Preservation/Access Projects (59) $16,348,127
- National Heritage Preservation Program (4) $2,355,846
Research Programs (126) $2,451,500
- Fellowship Programs at Independent Research Institutions (9) $1,866,500
- Summer Stipends (117) $585,000
Education Programs (34) $3,469,650
- Education Development and Demonstration Projects (16) $3,084,650
- Schools for a New Millennium grants (K-12 curriculum enrichment through collaboration with local cultural and educational institutions) (4) $357,000
- Humanities Teacher Leadership Program (to individual K-12 teachers for development and distribution of teaching materials) (14) $28,000
Public Programs (65) $541,402
- Humanities Projects in Libraries and Archives (42) $81,985
- Humanities Projects in Museums and Historical Organizations (21) $389,417
- Humanities Projects in Media (1) $60,000
- Special Projects (1) $10,000
NEH grants are awarded on a competitive basis. Throughout the year, humanities experts outside of the Endowment read all applications and advise NEH on the quality and significance of each proposed project.
Additional information about the National Endowment for the Humanities and its grant programs is available on the Internet at www.neh.gov.


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Triangle Assention
Triangle Assention
Last edited by RandallIsland; 11-18-2007 at 10:47 PM.
Triangle wires
Study in Triangles in nature
Why can't I ride over the bridge
Stone Masons Corner
Is it me, or is a "true" triangle specifically a man made shape. I was out and about quite a lot this weekend, and it's nearly impossible to find a triangle in nature that has straight sides. (just an observation- and nothing more)
One more:
Gave up with the lighting on the top box after I swallowed the torch. So I went looking for triangles in nature. These parrot flowers are as near as I could find in and around the house.
They could look spectacular with the right lighting and a more skilled photographer. Still, I like the diagonal composition, as it also splits the image into two triangles.
First of all, I'm not at all sure that these even qualify as triangles. They are, perhaps, the endoskeleton of a triangle.
I spent the afternoon riding trails in the mountains of Tehachapi in search of the right spot. I found two or three, but I'm just not in love with any one of them.
I like this first one, if only that is shows the true scale of these massive windmills.
I'm not happy with the position of the blades, especially in relation to each other. Also, there's a third windmill's blade peeking in the left margin.
Last edited by SNC1923; 11-19-2007 at 12:26 AM. Reason: embed exif
This is the image for which I had the highest hopes. It was difficult to reach and I spent quite a bit of time just keeping the bike upright. When I finally got everything organized, I had to shoot blind with the camera slightly below ground level in a depression. This is the best of the shotgun approach, and a worthy image, but the windmill is growing out of the bike. Aargh!
Live fully. Laugh deeply. Love widely.
BMW MOA Ambassador Emeritus / FOM / Roving Forum Moderator/
Selected Friends of Wile E Coyote/ A Million 100 thousand BMW sMiles
When I took this shot I saw three obvious triangles. Later the 4th jumped out at me.
Live fully. Laugh deeply. Love widely.
BMW MOA Ambassador Emeritus / FOM / Roving Forum Moderator/
Selected Friends of Wile E Coyote/ A Million 100 thousand BMW sMiles