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The roots of pediatric cancer are hidden deep within a child's DNA. The St. Jude—Washington University Pediatric Cancer Genome Project is the world's most ambitious effort to discover the origins of childhood cancer and seek new cures.
By comparing the complete genomes from cancerous and normal cells for more than 800 patients, we have successfully pinpointed the genetic factors behind some of the toughest pediatric cancers. We are now using multiple approaches to analyze cancer genomes even more deeply. We are also developing a state-of-the-art clinical genomics program to better diagnose and treat children with cancer.
Raw sequence data for all published results, as well as data analysis and visualization tools, are freely available. Explore them today to advance your research and help us find cures.
Selected Highlights
Sharing a powerful resource with the global scientific community
To fuel new discoveries and treatments, we offer researchers access to the world's largest collection of pediatric solid tumor samples and related drug sensitivity data at no charge. The resource, known as the Childhood Solid Tumor Network, is the result of a collaboration between St. Jude and the Howard Hughes Medical Institute and has already sparked research advances.
Original article: Nature, August 2017
News release: St. Jude unveils powerful resource to advance treatment of pediatric solid tumors
Scanning for immunotherapy opportunities in childhood cancers
We conducted the first comprehensive analysis of neoepitopes—potential targets of immunotherapies—in pediatric cancers. Going forward, researchers can use this library of potential targets to develop and test cancer therapies that use the immune system to fight cancer cells.
Original article: Genome Medicine, August 2017
Map offers scientists a new path to understanding retinoblastoma and degenerative retinal diseases
We created a genomic map of the intricate changes in the "epigenetic" organization of the nucleus to determine how retinal cells transition from immature cells to mature retinal neurons. The researchers also mapped the epigenome of retinoblastoma cells as they turn cancerous.
Original article: Neuron, May 2017
News release: St. Jude maps genome organization to link retinal development and retinoblastoma
Protein pair altered in a childhood leukemia
In collaboration with the Children's Oncology Group, we found genetic changes underpinning a subtype of acute lymphoblastic leukemia (ALL), the most common childhood cancer. The changes affect the interplay between DUX4 and ERG, two proteins that control crucial genes in human blood cells. The results have led to new diagnostic approaches in leukemia.
Original article: Nature Genetics, October 2016
News release: Genetic hallmarks of acute lymphoblastic leukemia subtype uncovered
Mapping the genome of an acute myeloid leukemia
We completed a detailed map of the genomic changes found in a childhood leukemia called core-binding factor acute myeloid leukemia (CBF-AML). The research identified new genetic changes that may work with known mutations to cause disease. It also highlighted genes that may influence relapse.
Original article: Nature Genetics, October 2016
News release: Researchers reveal genomic landscape of core-binding factor acute myeloid leukemia
Critical mutations identified in rare low-grade brain tumors
We discovered key mutations that drive the growth of rare brain cancers called low-grade gliomas and glioneuronal tumors. Potential therapies targeting some of these mutations are already being tested in clinical trials. The discovery may also help improve diagnosis of these tumors.
Original article: Acta Neuropathologica, January 2016
News release: Sequencing reveals genetic alterations for uncommon brain tumors in children
An elegant app for mining cancer genome data
We developed a Web-based application, ProteinPaint, that makes it easy for scientists to visualize and explore cancer genome data. The tool includes information on nearly 27,500 mutations from more than 1,000 pediatric patients with 21 cancer subtypes. ProteinPaint is freely available to the research community.
Original article: Nature Genetics, December 2015
News release: St. Jude researchers develop powerful interactive tool to mine data from cancer genome
Defining the genetic causes of childhood cancer
In a large-scale, landmark study, we found that nearly one out of 10 childhood cancer patients was born with an increased genetic risk for cancer. We also discovered unexpected links between adult cancer genes and childhood disease.
Original article: New England Journal of Medicine, November 2015
News release: New study suggests more than 8 percent of children with cancer have genetic predisposition
A dramatically improved tool for detecting alterations in tumors
We developed CONSERTING, a new computer tool for identifying mutations called copy number alterations (CNAs). The tool finds CNAs, which are involved in many cancers, with much higher accuracy and sensitivity than other techniques. CONSERTING is freely available to the research community.
Original article: Nature Methods, June 2015
News release: Scientists dramatically improve method for finding common genetic alterations in tumors
Large genetic alteration may hold key to treating aggressive infant leukemia
We found that a highly aggressive form of leukemia in infants has surprisingly few mutations beyond a known chromosomal rearrangement that affects the MLL gene. The findings suggest that targeting the alteration is likely the key to improved survival. The study is the most comprehensive analysis yet of this rare subtype of pediatric acute lymphoblastic leukemia (ALL).
Original article: Nature Genetics, April 2015
News release: Chromosomal rearrangement is the key to progress against aggressive infant leukemia
A first genome-wide look at childhood adrenocortical tumors
We pinpointed key mutations involved in pediatric adrenocortical tumors, which had never before been analyzed on a genomic scale. Genomic alterations affecting the genes TP53 and IGF2 were found to occur early in tumor growth, pointing to a key role in triggering tumor development. The results may help clinicians identify children with the most aggressive forms of the disease and lead to improved treatments.
Original article: Nature Communications, March 2015
News release: Researchers map "genomic landscape" of childhood adrenocortical tumors for the first time
Sun damage linked to childhood skin cancer
We found the first genetic evidence that sun damage contributes to melanoma in children and teens, underscoring the importance of starting sun protection early. We also found that melanoma in some teen patients has many of the same genetic alterations as conventional melanoma in adults and is likely to respond to the same therapy.
Original article: Journal of Investigational Dermatology, March 2015
News release: Sun damage causes genetic changes that predispose children and adolescents to melanoma
Understanding how leukemia cells survive chemotherapy
In collaboration with the Children's Oncology Group and the TARGET initiative, we discovered key details of how acute lymphoblastic leukemia (ALL) cells mutate to survive chemotherapy. The findings may improve early detection of mutations that drive relapse of the disease.
Original article: Nature Communications, March 2015
News release: Scientists trace genomic evolution of high-risk leukemia
Mutations in Ewing sarcoma linked to poor survival
We found that alterations in two genes, STAG2 and TP53, are associated with reduced survival for patients with Ewing sarcoma, a tumor of the bone and soft tissue. The findings are an important step toward improved diagnosis and treatment strategies.
Original article: Cancer Discovery, November 2014
News release: Gene sequencing projects link two mutations to Ewing sarcoma subtype with poor prognosis
Genetic clues lay foundation for new leukemia clinical trial
We pinpointed genes linked to a leukemia subtype known as Ph-like ALL and discovered that the subtype grows more common with age. We also learned that many patients might benefit from drugs already used to treat adult leukemias. Combined with earlier work, the findings lay the foundation for an upcoming clinical trial.
Original article: The New England Journal of Medicine, September 2014
News release: Genomic analysis reveals that high-risk leukemia subtype becomes more common with age
Mutations tied to brain tumors in young patients
We found new genetic mutations that occur most often in younger patients with a subgroup of brain tumors known as high-grade gliomas. The findings provide urgently needed drug development leads for this devastating cancer.
Original article: Nature Genetics, April 2014
News release: Gene sequencing project discovers mutations tied to deadly brain tumors in young children
Key gene identified for bone cancer
We discovered that mutations in the tumor suppressor gene TP53 are likely to play a key role early in the development of osteosarcomas, the most common childhood bone cancer. The study also helps explain why this tumor is often resistant to standard-dose radiation therapy.
Original article: Cell Reports, April 2014
News release: Tumor suppressor gene TP53 mutated in 90 percent of most common childhood bone tumor
Catching a brain tumor culprit
We identified the most common genetic alteration ever reported in the brain tumor ependymoma, as well as evidence that the alteration drives tumor development. The findings provide a new foundation for diagnosis and treatment of ependymoma and should aid efforts to understand and intervene against other cancers, including adult tumors.
Original article: Nature, February 2014
News release: Gene sequencing project discovers common driver of a childhood brain tumor
Potential new uses for existing drugs
We found the first evidence that rhabdomyosarcoma, a cancer of muscles and other soft tissues, might be sensitive to drugs that enhance a process called oxidative stress. The drugs killed tumor cells growing in the laboratory. Some medications that harness this cellular process are already on the market.
Original article: Cancer Cell, December 2013
News release: Gene sequencing project finds family of drugs with promise for treating childhood tumor
Two mutations to blame for majority of diffuse low-grade gliomas
We discovered that mistakes in two genes are responsible for more than 50 percent of diffuse low-grade gliomas, a subtype of the most common childhood tumor of the brain and spine. We also found evidence the tumors might be vulnerable to drugs already in development.
Original article: Nature Genetics, April 2013
News release: Gene sequencing project finds new mutations to blame for a majority of brain tumor subtype
Decoding ALS and other degenerative disorders
We discovered new gene mutations linked to a family of diseases that includes amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. The findings could spur new advances in treating some of the most common degenerative disorders of the muscle, brain and bone.
Original article: Nature, March 2013
News release: Two new genes linked to amyotrophic lateral sclerosis (ALS) and related disorders
Uncovering the genetic basis of high-risk leukemias
We discovered new genetic defects in childhood leukemia subtypes that exhibit dramatic chromosome loss and poor cure rates. We also identified a possible treatment strategy using drugs already used to treat other cancers.
Original article: Nature Genetics, January 2013
News release: Genetic basis of high-risk childhood cancer points to possible new drug treatment strategy
New methods for mining "junk" DNA
We developed a method to mine the repetitive DNA sequences at the ends of chromosomes for clues about the mistakes fueling cancer and insight into one mutation's contribution.
Original article: Genome Biology, December 2012
News release: Gene sequencing project mines data once considered 'junk' for clues about cancer
New leads on a rare leukemia subtype
We discovered a genetic alteration responsible for almost 30 percent of cases of AMKL, an uncommon subtype of childhood leukemia. The finding paves the way for desperately needed treatment advances.
Original article: Cancer Cell, November 2012
News release: Gene sequencing project identifies abnormal gene that launches rare childhood leukemia
Promising drug targets for common childhood brain cancers
We uncovered new genetic factors behind medulloblastoma, the most common malignant childhood brain tumor. Some of the genes are already the focus of ongoing drug development efforts.
Original article: Nature, July 2012
News release: Gene sequencing project identifies potential drug targets in common childhood brain tumor
Clues about clinical trends seen in nervous system tumor
We identified a gene mutation that may help explain why outcomes for children with advanced neuroblastoma, a tumor of the nervous system, vary dramatically depending on the child's age at diagnosis.
Original article: Journal of the American Medical Association, March 2012
News release: Genome sequencing initiative links altered gene to age-related neuroblastoma risk
New treatment possibility for eye tumors
We found new clues about why eye tumors known as retinoblastomas tend to develop rapidly. Based on the findings, we identified a promising treatment lead for this fast-moving cancer.
Original article: Nature, January 2012
News release: Gene identified as a new target for treatment of aggressive childhood eye tumor
Surprising genetic links for a high-risk leukemia
We found unexpected genetic alterations in a deadly type of childhood leukemia called early T-cell precursor (ETP)-ALL that could change diagnosis and treatment for children with this disease.
Original article: Nature, January 2012
News release: Cancer sequencing project identifies potential approaches to combat aggressive leukemia
Tracing the genetic underpinnings of brain tumors
We found that a startling 78 percent of the brainstem tumors known as diffuse intrinsic pontine glioma (DIPG) carried changes in two genes not previously linked to cancer.
Original article: Nature Genetics, January 2012
News release: Cancer sequencing initiative discovers mutations tied to aggressive childhood brain tumors
Speeding discovery by improving analysis methods
We developed a new computational model, CREST, to evaluate mutations and control for potential errors. This algorithm outperforms prior tools so well it is being adopted globally.
Original article: Nature Methods, June 2011


text:
Welcome to Keller Williams Realty Metro Atlanta!
Thanks for starting your real estate search with us.
Looking for a Rewarding Career? Come work with the best!
Click Here for More Information!
Our Mission:
To build careers worth having, businesses worth owning, and lives worth living.
Our Vision:
To be the real estate company of choice.
Our Perspective:
A training and consulting company that also provides the franchise systems, products, and services that lead to productivity and profitability. Keller Williams thinks like a top producer, acts like a trainer- consultant, and focuses all its activities on service, productivity, and profitability.
Our Trusted Partners:

subset: commoncrawl


text:
This item is currently out of stock.
This Sundown blackout panel has been laboratory-tested to block out over 99% of intrusive light, unwanted noise and can help you save on home heating and cooling costs. Sundown curtains offer a unique blend of fashion and function for any home décor. Perfect for the bedroom, kid's room or nursery providing an ideal sleep environment. The magic is in the Thermaback construction featuring an innovative foam-backing that's applied to the fabric and allows you to enjoy all of the light-blocking, noise reducing and energy saving benefits.
General Disclaimer: We aim to provide accurate product information, however some information presented is provided by a 3rd party and is subject to change.See our disclaimer.
- Sold as single panel
- Solid color panel in pretty lilac purple
- Thermaback construction with innovative foam backing
- Blocks over 99% of light compared to ordinary curtains
- Reduces unwanted noise
- Helps to save on home heating and cooling costs
- Creates the optimal sleep environment
- Easy care, machine washable
- Accessories and décor are not included as shown
- Curtain rod and other panel are sold separately
- Material: 100% Polyester
- Model number: 18299042X095LPR
- 95"L x 42"W
Return Policy
This item has a special return policy.
This item has a special return policy.
If you wish to return your online order, please visit your order history to start the return process. If you have any issues, contact our Customer Care Support Center at 1-866-BIG-LOTS (244-5687) for assistance with making your return. Please be prepared to provide your order number and email address, or your rewards number, so that we may better assist you.
For return terms, see our full Returns Policy.
For return terms, see our full Returns Policy.
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Thank you for visiting us! Park Avenue Yarns is a local yarn shop in League City, Texas, just outside of Houston. We love yarn, fabric and fiber, and we love our customers even more! Please take your time and stay awhile, and please let us know if you have any questions. We are here to help!
Call Us (832) 932-0300Fax (832) 932-0300
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A U.S. District Court has ruled that even if ABC discriminates in show casting, it doesn't matter because they're protected by the First Amendment.
Back in April, Christopher Johnson and Nathaniel Claybrooks sued ABC after both tried out for the coveted role of the network's "Bachelor," and weren't selected.
The two accused the network of racial discrimination suggesting "they and other minority applicants have been denied the equal opportunity to contract to be the Bachelor or the Bachelorette."
Both men claimed this would be in direct violation of 42 U.S.C. § 1981, a statuate that "prohibits intentional race discrimination in the making and enforcing of contracts involving both public and private actors
Note that through 16 seasons of "The Bachelor" and eight seasons of "The Bachelorette" there has never been a person of color as either of the titular characters.
The two allege that decision is not a mistake, suggesting ABC makes a conscious decision based on the show's "predominantly white viewership."
Despite the men's assertions, U.S. District Court Judge Aleta Trauger ordered the motion to dismiss.
According to Trauger's ruling, though the court may find ABC responsible of prejudice, they're protected by the First Amendment right to control the show's creative content.
From the suit ruling via Deadline:
"Thus, the court must assume, as alleged in the Amended Complaint, that the defendants did discriminate on the basis of race, that they did so to conform the content of their Shows to cater to the viewpoint of their target audience concerning interracial relationships, that the Shows' content thereby perpetuates racial stereotypes about interracial relationships, and that the plaintiffs seek to alter/correct the defendants' casting decision process to address that issue.
Regardless, as discussed herein, the First Amendment protects the defendants' ability to control the content of their own programs unilaterally … because the defendants – not the plaintiffs – are entitled to control the casting of their own programs in the manner in which they see fit."
According to Trauger, § 1981 would force ABC to "employ race-neutral criteria in the casting process," which would also regulate the creative content of its shows.
Essentially, even if Claybrooks and Johnson are right, they will never win their case since ABC is protected by the First Amendment.


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Experts dismiss prediction of global wine shortage
Experts downplay prediction of coming global wine shortage
Confusion abounds over a prediction that a wine shortage could be looming.
A Morgan Stanley report released this week said worldwide wine demand exceeded supply by nearly 300 million cases in 2012. The study blamed the shortfall, the greatest in 40 years, on bad weather and fewer vineyards, and it added there may not be enough wine in future years.
But don't start hoarding your wine, because analysts are seeing it differently.
"I can't say we've felt any shortage," said Mulan Chan-Randel, who buys Rhone varietals and wines from the south of France for K&L Wine Merchants in San Francisco. "We may not be having as many closeout specials as we had during the recession, but I don't see anyone ratcheting up the prices, either. We definitely felt an increase in consumption, especially with Millennials. But we've been able to keep up."
Analysts say wine production has actually increased significantly and consumption is stabilizing. In fact, California's harvest is expected to reach 4 million tons, nearing last year's record.
Wine experts in California and the world argue that the industry is in fine shape and that much of the reduced production has been intentional because of a wine glut.
And most important, they say, is that there is plenty of wine to go around and prices should stay consistent.
'Report is just wrong'
"Morgan Stanley's report is just wrong," said Rob McMillian, executive vice president of Silicon Valley Bank and founder of its wine division. "In 2010 and 2011, we also thought we were trending toward a shortage in the United States, but 2012 was a record production year. This year is almost as big. Everything we're seeing is leading us to believe that there won't be enough tank space for all the production here."
The International Organization of Vine and Wine, an intergovernmental winemaking and viticulture agency, just released its report and predicts that global wine production will see a spike of 8.8 percent in 2013 - its highest level in seven years.
"In Europe, after five modest consecutive harvests and an exceptionally low 2012 harvest, 2013 wine production may be qualified as relatively high," according to the organization.
California, which is responsible for 90 percent of all U.S. wines and is the fourth-leading wine producer in the world behind France, Italy and Spain, has had 19 years of consecutive growth.
Last year, winemakers in the state sold a record 360.1 million cases, a retail value of $34.6 billion, according to industry consultants Gomberg, Fredrikson & Associates.
"Analysts must have looked at the decline in Europe but didn't take into consideration that growers there were overproducing," McMillian said. "Europeans have ripped out 100,000 hectares of vines for that very reason."
Supply and demand
The report's authors, Tom Kierath and Crystal Wang of Morgan Stanley's Australian consumer and beverage branch, declined to be interviewed.
Stephen Rannekleiv, a wine industry analyst for Rabo Bank in New York, said initially it did look like there would be a shortfall, but it didn't materialize.
"Analysis of this sort is a bit of a challenge," he said. "Spain, Italy and France had much better harvests this year than what was expected - even increases over previous years. There's no looming shortage that we can see, barring some unforeseen shock to supply or demand. All you have to do is look at bulk wine pricing, which has really been coming down, to realize there's no shortage."
But consumption continues to climb; in the United States, last year's sales saw a 2 percent increase over 2011. On the production side, vineyards continue to shrink - China is the only country consistently expanding its vine acreage. The Morgan Stanley report concludes that those two elements make predicting a shortage a simple case of supply and demand.
Wine by the numbers
The harvest: There are more than 1 million wine producers in the world, producing approximately 2.8 billion cases of wine each year.
Changing tastes: Global wine production peaked in 2004 and continues to drop. In 2012, production declined to its lowest level in more than 40 years. Global consumption declined in 2010 but continued growing in 2011 and 2012.
Reason to whine? Data suggest there may be insufficient supply to meet demand in coming years, as current vintages are released.
Europe's share: In the past few years, production declines have continued in France, Spain and Italy while new-world production has peaked.
Bottoms up: The French remain the largest consumers of wine, with Americans now a close second. The U.S. and China are the main drivers of consumption growth globally.
Source: Morgan Stanley
Stacy Finz is a San Francisco Chronicle staff writer. E-mail: firstname.lastname@example.com Twitter: @sfinz


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A place for atheists in Ghana to meet. Bring your ideas and lets keep the discussion going.
Members: 11
Latest Activity: Nov 29, 2012
Started by Tarbouriech Aug 6, 2011. 0 Replies 0 Likes
Humankind was born free.Nature has created neither titles, nor religions nor Churches, nor censorship or property.Humankind has become itself when it came out of prehistory after a long struggle…Continue
Started by Tarbouriech Sep 28, 2010. 0 Replies 0 Likes
Appeal for an International Association of the Free ThoughtAppel pour l'Association Internationale de la Libre Pensée…Continue
Tags: http://www.cilalp.org
Started by janna thorson-jabr Feb 1, 2010. 0 Replies 0 Likes
Dear friends,I am working to compile for publication a book of essays/articles about the experiences of atheists around the world.I am from the United States, where religion is usually a personal…Continue
the Humanist Association of Ghana is hosting Ghana's first ever International Humanist Conference on November 23-25 in Accra.
Please check out the new Humanist Association of Ghana
© 2019 Atheist Nexus. All rights reserved. Admin: The Nexus Group. Powered by


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Category:OWASP Education Project
Welcome to the OWASP Education Project
Web Application Security Education and Awareness is needed throughout the entire organization, each area and level of organizations have specific needs and requirements regarding education. A manager needs other information than a security professional or developer. Novices to the profession require other training than people with several years of experience.
This Education project aims to provide in building blocks of web application security information. These modules can be combined together in education tracks targeting different audiences.
The first list of modules can be found here.
Goals & Roadmap
Currently the project goals are to create Educational Tracks:
- A Web Application Security Primer Track for beginners (4 hours)
- What developers should know on Web Application Security Track for developers (4 hours)
- Create a consolidation page of OWASP presentations performed in the past with the possibility to add comments
- ...
Further breakdown of tasks and future developments are listed in the road map.
Project Guiding Principles
This project aims to provide in building blocks of web application security knowledge that can easily be integrated in awareness sessions or presentations on this topic. The building blocks provided by this project can then be bundled together in eduction tracks.
An important guideline is therefore that the material produced is modular.
Resources and links
This project is not standalone. There is an awfull lot of information that can be found throughout this site and from other resources on the Internet.
This project will draw pieces of information from:
- The Video's
- The presentations, currently being inventorized in the consolidation page of OWASP presentations¨
- WebGoat
- ...
One of the modules to create will be a Resources module, not limited to OWASP.
Feedback and Participation:
We hope you find the OWASP Education Project useful. Please contribute to the Project by volunteering for one of the Tasks, sending your comments, questions, and suggestions to the mailing list.
Project Contributors
If you contribute to this Project, please add your name here.
Project Lead:
This category has only the following subcategory.
- ► OWASP Boot Camp Project (empty)
Pages in category "OWASP Education Project"
The following 10 pages are in this category, out of 10 total.
Media in category "OWASP Education Project"
This category contains only the following file.
- Setting up a Secure De...


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Student Honors Associations
Student Honors Association (SHA)
The Student Honors Association (SHA) is open to all students enrolled in the Honors program. SHA sponsors student and student/faculty service and social activities, sponsors student attendance at MEHA, and elects the student officers who serve on the Honors Committee. Contact SHA President Lauren Onianwa for more information.
Honors Director's Advisory Board
The Honors Director's Advisory Board was formed in 2009 to help foster communication between the Honors student body and the Honors administration. Students are selected to participate for one academic year but may reapply for consecutive years.
Honors Regional and National Conferences
The Wright State University Honors Program is affiliated with the Mid-East Honors Association (MEHA) and the National Collegiate Honors Conference (NCHC). Honors staff regularly attend and present at the regional and national conferences, often accompanied by Honors students. Scholarships are available through NCHC; consult the NCHC website or the Honors office for more details.
National Honor Societies
Alpha Lambda Delta
Alpha Lambda Delta (ALD), an honorary society for first-year students, has existed on campus since 1987 and is administered through the Division of Student Success. Membership is by invitation only to students who earn a 3.5 GPA or better during their first year. ALD members are eligible to apply for eighteen to twenty $3,000 graduate fellowships that are offered each year. For more information, contact the Division of Student Success.
Phi Kappa Phi
Chartered in Spring 1990, Wright State Chapter #252 of The Honor Society of Phi Kappa Phi inducts juniors, seniors, and graduate students from all majors who rank near the top of their classes. The National Society, headquartered in Baton Rouge, LA, has an attractive scholarship and award program. The chapter annually elects two Student Vice Presidents to serve one-year terms of office. Membership in Phi Kappa Phi is by invitation only and is an honor that lasts a lifetime.
Phi Theta Kappa
An honorary society for two-year colleges, Phi Theta Kappa chartered an alumni chapter at Wright State in 1993. Phi Theta Kappans who transfer to Wright State to complete their baccalaureate may apply for a $1500 (one-year renewable) scholarship. The Honors Program encourages the participation of Phi Theta Kappa members, particularly in departmental Honors. Honors courses completed at other institutions will count toward completion of Honors designation requirements at Wright State. Consult with an Honors advisor.


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|Home >> Course Descriptions >> College of Arts and Sciences
|Forensic Psychology.
|Three semester hours.
Examines psychology of criminal offenders. Familiarizes students with psychological procedures used in evaluation of criminal defendants, offenders and psychological profiling of criminals. Considers psychological research on crimes ranging from prostitution and violent sex crime to serial murder. Prerequisite: PSYC 2301or SOCI 1301 or CRIJ 1301.
Home - General Information - Student Services -
Academic Undergraduate Regulations -
Undergraduate Degrees - Academic Graduate Regulations -
Graduate Degrees - Course Descriptions - Faculty -
Appendix A - Appendix B - Appendix C - Appendix D


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Welcome to Grove® Art Online
- The foremost scholarly art encyclopedia, updated regularly and covering global art and architecture from prehistory to present day
- Includes peer-reviewed articles contributed by nearly 7,000 scholars from around the world, accompanied by images, bibliographies, and links to additional resources
Murals in Latin America
During the late 19th century, mural painting in Mexico expanded from its colonial role in church decoration and began to be used for secular decorations, often with the goal to educate or convey political ideas.
Cultural Revolution
Beginning in 1966, the Cultural Revolution in China had a profound effect on the arts; this decade of political upheaval saw the destruction of cultural objects as well as attacks on artists regarded as bourgeois.
In this update, Grove Art publishes 10 article revisions and 24 emendations.
Collection Guides
Join Oxford Art Online on a tour of unique art collections around the world! Written by experts and curators, our Collection Guides present the history and highlights of museums and galleries.
Grove Guide to the Art Market
Explore the new Grove Art subject guide on the art market, which brings together articles related to finance, art law, provenance, cultural heritage, collecting, connoisseurship, galleries, auction houses, and dealers.
UpdateGAO is an ongoing initiative to revise Grove's articles in collaboration with their original authors, yielding updates to reflect recent developments and new scholarship. Have you contributed to Grove and want to update your article(s)? Let us know.
Latin American Art
Grove Art continues a major initiative to revise and expand Grove's content on Latin American art and architecture. Led by Tom Cummins at Harvard University, this project includes scholarship on topics from the Pre-Columbian period to present day.


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New Laser-Cutting Machine Expands Fabricator's Capacity to 1/2 in. Stainless
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Thursday, March 1, 2012
Precision sheetmetal fabricator Cardinal Metalworks, Inc., Burgaw, NC, has added a Mazak Super Turbo-X MK III 2500-W laser-cutting machine, with load/unload automation, to its stable, allowing the plant to expand its workpiece capacity to 1/2-in. stainless-steel and 3/4-in. carbon-steel plate. Cardinal Metalworks, an ISO 9001:2008-registered company, employs 50.
See also: Mazak Optonics Corporation
Related Enterprise Zones: Fabrication
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The Cube Critics take on fairy tales and mumblecore
This week, Stephanie and Euan chat on about post feminist fairy tales and the curious or maybe not so curious film genre, "mumblecore."
Catch the Movie Maven Stephanie Curtis and arts reporter Euan Kerr in their cubes every Thursday on Cube Critics, which is produced by Chris Roberts. You can also follow Euan and Stephanie on Twitter @cubecritics.
1 of 1


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San Diego Humane Society has a handful of major events throughout the year and lots of smaller events each month.
Attend our events and participate in promotions, knowing that your attendance or purchase directly benefits the animals in our care and the programs we offer.
Lectures, Meetings and SDHS activities are listed below. Third-party fundraising events and promotions benefiting San Diego Humane Society are listed here. More featured events can be found here.
= Open
= Ticketed
= Recurring


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This is about and dedicated to the men of HQ Company 4th Marine Regiment 3rd
Marine Division Communications. This being Radio, Radio Relay, Wire, Teletype
and anything relating to conveying of information via a wire or radio signals.
The location being The Republic of Vietnam mainly focusing on the years of 1967
and 1968, but also 1966 and 1969.
HQ 4th Marines were located at Camp Evans in 1967 then moved to Camp JJ
Carroll in January 1968 then to Ca Lu later that year. Also teams or individuals
would be sent to outlaying LZ's, Hill's, or smaller fire bases to maintain
communications with HQ or other units.
This Web Site is expected to be under a constant change. It's for the enjoyment
of those that served in the 4th Marines, their families and friends to share
pictures and memories of then and now.
I hope that all you Marines of the 4th and your family and friends enjoy our
pictures and memory's posted here and also welcome any persons just stopping
by to view what we have here. Feel free to e-mail me with any comments or
things you wish to see added. As stated I plan on this being a site in constant
flux. As members of the old group are found or find us we hope to add their
memorabilia to this collection.
Carl V Stone II
I want to give a special thanks to my wife for setting me on this direction of
finding and reuniting with fellow Marines of long ago. And especially to JR for
being the one to rekindle that feeling of camaraderie and friendship a fellow
Marine should never lose. Thanks JR.
HQ Company 4th Marine Regiment
3rd Marine Division
Contact the
Web Master
Links to other sites below:
Facebook Link
Regiment Insignia Then
Regiment Insignia Now


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Chelsea have announced the signing of Kurt Zouma from St Etienne, where the defender will remain on loan for the rest of the season.
The 19-year-old has signed a five-and-a-half year contract at Stamford Bridge.
He will remain in France for the rest of the season, before joining up with his Chelsea team-mates at the end of this campaign.
Manager Jose Mourinho said Zouma is Chelsea's fourth and final signing of the January transfer window, following the captures of midfielder Nemanja Matic from Benfica, Mohamed Salah from Basle and Bertrand Traore, who immediately was sent on loan to Vitesse Arnhem.
"Job done," Mourinho said.
"The last one in the transfer window. In almost every position we have the present and also the future."
Chelsea moved for Zouma now as other sides were lining up to recruit the defender, who could spend next season on loan or at Stamford Bridge.
"If we don't do it now, probably we can't do it in the summer because other clubs were also very strong on him," Mourinho added.
"So we did it, now he stays at St Etienne, pre-season he will join us.
"We will see if it is to stay or if it is to go on loan."
Mourinho has spoken of building a team for the next decade and Zouma's acquisition fits with his brief of recruiting young players full of potential.
Mourinho added: "He's another young player in the profile of some Chelsea signed in the couple of last years.
"We liked the profile, we think he's very much adapted to the Premier League.
"He is a young player for a position where we also need the future.
"He's a player with big potential, physically ready. One thing is to be physically ready, another thing is to be tactically ready. Well done Chelsea."


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Liev Schreiber has set his sights on the story of the man who inspired Sylvester Stallone to write his Oscar-winning screenplay.
"There's a guy named Chuck Wepner, the Bayonne Bleeder. He's the guy that 'Rocky' was based on," Schreiber told MTV. "He went 15 rounds with [Muhammad] Ali in 1974 and it's this wonderful story of what happened to that guy as a result of his rise to fame."
Considering he already got jacked up for the role of Sabretooth in "X-Men Origins: Wolverine," getting ready to play Wepner shouldn't be too tough.
Wepner, who started fighting as a Marine, finished his boxing career with a record of 35-14-2, including 17 knockouts and more than 300 stitches.
"Rocky" left Wepner feeling a little shortchanged, as he never saw a penny of the millions that the franchise earned for Stallone and others. In 2003, Wepner filed a $15 million lawsuit.
"It's been 28 years of slaps on the back, hugs, kisses and broken promises," Wepner said at the time during a news conference at Mickey Mantle's restaurant. "I'm not mad at Sly, but I am fed up. I've talked to him 8 or 10 times but after 28 years, it's time he came to the table. I'd love to have him sit down with me."
They settled for an undisclosed amount three years later.
Wepner may have been the inspiration for "Rocky III," as well, which saw Balboa fight pro wrestler Hulk Hogan. In 1976, a year after losing to Ali, Wepner squared off against Andre the Giant.
"That's the next thing I'd like to do," added Schreiber. "It's just a remarkable, hilarious film and I hope we get to make it."
Let's hope Schreiber does right by the Bayonne Bleeder.


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A veteran Democrat from Houston serving on the House Committee on Homeland Security is crossing party lines to support Republican-sponsored legislation to create a yardstick for security along the Southwest Border.
Congresswoman Sheila Jackson Lee says her move will help win the comprehensive immigration reform that she also supports.
Jackson Lee has joined forces with Rep. Michael McCaul, a Republican from Austin, and Sen. John Cornyn, a Republican from San Antonio, to co-sponsor the measure.
"I see this as a neutral, non-political issue that ties the necessity of security for the homeland with comprehensive immigration reform," says Jackson Lee, a long time member of the House Committee on Homeland Security who was elected to Congress in 1994. "I believe this legislation is a fair partnership for getting immigration reform."
Jackson Lee vowed to work with GOP counterparts in the House, including McCaul, chairman of the House homeland security panel.
"I want to see border security dealt with in a positive way," Jackson Lee said. "We can work together to get things done on both border security and immigration reform. It's like eating ice cream and having a great piece of pie at the same time."
McCaul said he hoped his committee would act on the border metrics legislation sometime in May.
McCaul said the bill addresses the skepticism of those who "have seen that promises of border security coupled with immigration reform have gone unfulfilled in the past."
Not all Texans agree. Congressman Pete Gallego, a Democrat from San Antonio, is questioning the practicality of requiring increased federal security measures while Customs and Border Patrol is under threat of furloughs and across-the-board budget cuts.
"The math doesn't add up," said Gallego, whose congressional district includes 800 miles of U.S.-Mexico border. "You can't reduce border wait times and apprehend more people with fewer employees and less money. Those who supported sequestration should see that."


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Theme-Based Voir Dire
Don't Pick a Jury. Persuade a Jury.
Would you like to win more jury trials? If you are a typical trial attorney in the United States the obvious answer is yes. Of course you would like to win more often. Who wouldn't? However, the real question is not whether you want to win more, rather, how can you win more? The answer to this question may be simpler than you think. In fact, the answer undoubtedly lies with the twelve strangers you pick to act as trial jurors in your case. The answer to better results lies with the jury. Pick a better jury and get better results. Simple as that.
Every trial attorney wants to win. To that end, many of us have gone to seminar after seminar, taken online classes, purchased books and conferred with experienced attorneys to look for tips to getting an edge on our opponent so we can prevail in court. Even though we all do that type of searching many of us don't have any greater results in court to show for all of our effort. Why not? Typically the answer is because the searching trial attorney has not found the area that needs improvement. If you pick the same type of jury every time, your advanced skills in Opening Statement, Cross-Examination or Closing Argument likely fall on deaf ears. Even the most experienced trial attorney with great oratory skills cannot overcome a jury that was ill picked and that is opposed to the attorney's position. If you don't believe me do an experiment. Try to convince a "birther" that President Obama was born in Hawaii. Or try to convince Al Gore that humans don't contribute to climate change. And since we are in an election year, try to convince your friends that the candidate from their opposite party affiliation won any of the debates. You can see where I am going with this. If your audience is against you then anything you do or say will not make a difference. Even the most righteous cases can fail if the trial lawyer does not pick an effective jury. Pick a better jury and get better results.
In the hundreds of jury trials my partner and I have tried we found that the most effective way to pick a winning jury is to begin the persuasive process from the very moment you stand before the prospective jury during jury selection. We win a lot of cases. But to do so, we don't just pick twelve people we think will vote for us. We don't just pick a jury. We persuade a jury. From the very moment we stand before the jury we attempt to persuade the jury by introducing our theme and theme-lines of the case. If this is done effectively, the trial lawyer will be able to tell the jurors that are open to his or her position and at the same time expose any biases that may not be found during a typical "can you be fair" voir dire. Try it and you will see better results immediately.
Persuasion is the primary goal and skill of every trial lawyer. If you cannot persuade trial jurors you cannot win jury trials. It's as simple as that. This is especially true in the criminal law arena. Every criminal defense attorney will tell you, and every jury study on the subject corroborates, that most prospective jurors believe the accused defendant is guilty even before the prospective juror knows anything about the case. Even the charges! It is even more true in the most serious cases such as murder, child molest and gang cases. There are also equally significant biases in civil court. Given the undisputed reality of jury selection if you want to win jury trials you must be able to persuade people whom are against you. You must also have the ability to change a person's mind.
That is not to say that sometimes the Deputy District Attorney will gain a conviction even though he or she is non-persuasive and incompetent. After all, someone has to win. When attorneys such as this win the jury trial it is typically a function of a flawed jury trial system that stacks the deck against the defense attorney and defendant. It is typically because of an inherent bias in the jury trial system against the accused. Jury trial studies support what criminal trial lawyers have known for years: namely that the prospective jurors want to convict the defendant as part of a knee jerk reaction to being part of the jury process. And if the trial attorney engages in a "can you be fair" voir dire, that lawyer will likely lose his case. Because the "can you be fair" voir dire asks the prospective juror questions that beg for a politically correct and expected answer. The most typical answer to the question whether a prospective juror can be fair is "yes, I can be fair." Yet, we all know from the jury studies in the field that prospective jurors believe the accused defendant is guilty. How can we reconcile these facts? And when you think about it, what has the trial attorney achieved when the prospective juror says, in front of 100 strangers, that he or she can be fair? "Can you be fair" voir dire is losing voir dire. "Can you be fair voir dire is the trial lawyers first step towards failure in the courtroom.
Knowing this information can help us all become more effective trial lawyers and win more cases. Once the trial lawyer realizes the typical juror is against him or has significant biases to the attorneys or client's position, he can make a better assessment as to what jurors he or she would like to keep. The best way to pick a better jury is to discuss the theme and theme-lines of your cases and ask theme-based questions during voir dire. Whereas the typical voir dire asks; "can you be fair" which elicits a predictable response, theme-based voir dire discusses the theme of the case with the jurors at the earliest phase of the jury trial. For example, in a jury trial where your client is accused of child molest and your defense is your client defendant was falsely accused, a great line of theme-based questioning may be: "How many of you(prospective jurors) have been falsely accused of something from someone else?" "How did it make you feel?" "What did you do as a result of the false accusation?" You will be shocked at the responses. Instead of asking the prospective juror whether he or she subjectively believes he or she is fair, it is more important to determine whether they have anything in their background that may make them more open or understanding of your case. As this example illustrates your discussion introduces the theme of your case from the very beginning of the case. The effective attorney does not wait until the Opening Statement. It's too late. The jury panel was already sworn in. And if the jury is against you then nothing you do or say thereafter will be effective.
Persuasion begins from the first moment you stand before the jury. And theme-based voir dire is persuasive voir dire because you let the jury know what the issues are and you let them in on the important aspects of your case from the beginning. It should also be noted theme-based voir dire is not one-way voir dire where the attorney asks the questions and the prospective juror answers. No. Theme-based voir dire is a two-way street. The attorney gets information from the juror and, at the same time, the attorney gives information to the jury.
That is how you persuade a jury. You give information as much as you receive it. Once you begin this process of introducing your theme as early as possible you will find that you can more precisely and accurately pick jurors that are favorable to your case. As an additional example, in a recent case my client was accused of child molestation. My client said he didn't do it. There were several witnesses. However, the way I beat the case and got an acquittal was because I began persuading the jury from the first moment I stepped before them. I didn't engage in a "can you be fair" voir dire. I already knew the answer they would give and I knew they could not be fair. After all, my client was accused of raping and molesting a young girl. Instead I conducted a theme-based voir dire. I asked the jurors questions about their own life experience of being accused of something they did not do. I backed it up with questions about what I call the "Billy Graham Rule." Evangelist Billy Graham described in his auto-biography that in his whole career he made it a point to never be in his office alone with a woman with the door closed. In his book he indicated two separate reasons for this rule. First, he did not want there to be any appearance of impropriety and second, he didn't want to give anyone the chance to falsely accuse him of anything untoward. By the time I discussed the falsely accused line of questions and the Billy Graham Rule I think it was pretty clear that the jurors believed people could be falsely accused and those false accusations may have severe consequences.
After a four week jury trial the jury acquitted my client. Had I engaged in a standard "can you be fair" voir dire, I am convinced I would have lost. Every juror would have said "yes" they can be fair and they would have convicted my client. However, since I discussed the actual issues of the case from the very beginning and framed the issues in a light most favorable to my client I am convinced the jury saw the case through my client's perspective. We won. Not because of a great Opening Statement or a brilliant Argument. Rather, I won because I had twelve jurors that were open to my defense.


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Center your living space around the Eliston metal cocktail table to show off your cool industrial style. The table is made from metal, with details like rivets and chains that provide a unique touch. An oiled bronze finish adds antique appeal for the look of a treasured flea market find.
The Curated Eliston Metal Cocktail Table with Chain Detail by Universal at Morris Home in the Dayton, Cincinnati, Columbus, Ohio, Northern Kentucky area. Product availability may vary. Contact us for the most current availability on this product.
A mix of styles, medias, tones, and texture, the Curated collection invites you to explore its artfully crafted and effortlessly chic collection of furniture for every room in your home. Curated derives from a sense of comfortable chaos, with pieces designed to be mixed and matched to create a living space that perfectly reflects your style. Whether you pair an upholstered bed with rustic storage pieces for an urban rustic look, or pair that same bed with a metal nightstand and desk for a French vintage style, you can be comforted knowing that either combination is designed to work together. Upholstered elements, metal accents, and rustic woods mix together beautifully for a look that is as sophisticated as it is relaxed and welcoming. Classic staples can be mixed with modern accents for an eclectic look and feel that's all your own. With pieces for the bedroom, dining room, office, and living room, Curated awaits your discerning eye; an array of items that can be beautiful on their own, but together serve as more than the sum of their parts.
The Curated collection is a great option if you are looking for Rustic
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These images are representative of this group as a whole and may differ from this item.
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Morris Home Showrooms:
(Morris Home - Florence - 8040 Burlington Pike
Florence, KY 41042: (859) 282-3400 Store Profile)
(Morris Home - Cincinnati - 11765 Commons Drive
Springdale, OH 45246: (513) 671-8888 Store Profile)
(Morris Home - Dayton - 2121 Harshman Road
Dayton, OH 45424: (937) 910-7000 Store Profile)
(Morris Home - Centerville - 5695 Wilmington Pike
Centerville, OH 45459: (937) 433-0500 Store Profile)
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Columbus, OH 43240: 614-441-4567 Store Profile)
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Ashley Homestore Locations: (Ashley Homestore Dayton - 161 Mall Woods Drive. Dayton, Ohio 45449: 937-439-0900) (Ashley Homestore Fairborn/Beavercreek - 2850 E-Centre Drive. Fairborn, Ohio 45324: 937-874-7140) (Ashley Homestore Springdale - 11755 Commons Drive. Springdale, Ohio 45248: 513-619-6700) (Ashley Homestore Kentucky - 8040 Burlington Pike. Florence, Kentucky 41042: 859-282-5500) (Ashley Homestore Cincinnati - 4530 Eastgate Boulevard. Cincinnati, Ohio 45245: 513-346-5500) (Ashley Homestore Mason - 5600 Deerfield Boulevard. Mason, Ohio 45040: 513-770-6200) (Ashley Homestore Cincinnati - 9687 Colerain Avenue. Cincinnati, Ohio 45251: 513-245-5700) (Ashley Homestore Columbus - 3622 West Dublin Granville Road. Columbus, Ohio 43235: 614-652-6900) (Ashley Homestore Reynoldsburg - 2800 Brice Road. Reynoldsburg, Ohio 43235: 614-729-6199) (Ashley Homestore Columbus - 3883 Gramercy Parkway. Columbus, Ohio 43219: 614-473-9446) (Ashley Homestore Columbus - 1280 Gemini Place. Columbus, Ohio 43240: 614-441-4566)
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Zawinski not withstanding, regular expressions are a hugely useful addition to a programmer's toolbox. I learnt about them from Jeffrey Friedl's excellent Mastering Regular Expressions1.
Why am I thinking about this now?
So, I was asked to review a perl script and it was pretty good, apart from the fact that the main regex2 didn't quite match all the expected patterns.
The line to match was:
Other valid values within the tags included
quick,brown,fox or
quick brown fox.
And the regex in the script was:
As you can see, there were also a few unnecessary backslashes.
I suggested
[^<]+ instead of
\w+ with my reasons.
The developer changed the regex to:
Okay slightly better, but it still didn't match all the possibilities.
I pointed out a valid pattern it didn't match and asked again for
This was the result:
Okay, fine. The
\s space matchers are redundant, but at least it covers everything.
So basically, if you find yourself writing a bunch of regex regularly, and you don't really understand it, you could do worse than read Friedl's book.
1. Not an affiliate link
2. I know… "parsing" xml with regex will unleash cuthulu or something. It's not my script.


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Deadmarsh, Lefebvre looking set to return
[media-credit name="nhl.com" align="alignright" width="130″][/media-credit]
[media-credit name="nhl.com" align="alignleft" width="130″][/media-credit]
Believe it or not, the Avalanche has a team policy about assistant coaches: they can't talk to the media about ongoing, current team concerns. And the team will not announce anything about them, transaction-wise. For instance, if an assistant coach isn't coming back, they will not release that information publicly.
It's one of their quirkier policies, but as long as I know the score, I'm OK with it. So what I believe to be the truth about the Avalanche's assistant coaches, Sylvain Lefebvre and Adam Deadmarsh is: they'll both be back under Joe Sacco.
There were rumors that Lefebvre might leave to coach the new Sherbrooke team in the QMJHL this coming season, but when I asked if there were any changes to the Avs' assistant coaching spots – Lefebvre's in particular – I was met with silence. Which means, from what I gather from that, he's coming back.
I'm sorry, but I'm partial to both guys, being original Avs and all. So I'm happy about this news-non news.
I'm getting older, which means by definition I'm getting more sentimental. Those "good old days" of that first Avs season get sweeter and sweeter in my mind's rewind of life. I mean, put yourself in my shoes for this one: you cover an NHL team in your first year, and it's not only one that comes into a new city, but it wins a Stanley Cup – but better than that (for me, as an "objective" reporter) they were full of great guys and great players and great personalities.
Lefebvre was always very quiet and serious as a player. Very business-like, and he hasn't changed. He is the prototypical family man, only caring about work and family, in reverse order. He and Uwe Krupp were a very good defensive pair. Lefebvre was the guy who stayed back all the time, while Krupp had a little more license to roam.
His career never was the same after he left for the New York Rangers as a free agent, but his bank book got a lot bigger, so good for him. But I always wish he'd stayed, just for his insightful analyses of the game. Unfortunately, I don't get to talk to him much on the record anymore, but it's always good to see him.
Deadmarsh? Everybody loves Deader. My very first, lasting memory of Deadmarsh was seeing him flip his floppy hair from one side to the other, as he boarded the team bus/plane on the Avalanche's very first road trip ever – a preseason trip in 1995 that saw the team and media all travel together, from Denver to Cornwall, Ontario, Montreal, Ottawa, Hamilton, Ontario and Hartford Conn.
Deadmarsh had long, unruly hair and just continually flipped it from his right to left side.
He became a favored guy to talk to, not necessarily for the excitability of his words, but for his genuine passion for the game and keen insight. It's always been a regret of mine and everyone else who has known him that the fates conspired to end his playing career early, but he still won a Cup here and had several good years. It could have been worse.
I'm sure most Avs fans will agree: it's good to see them still around.


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ENGS 32: Electronics: Introduction to Linear and Digital Circuits
Identical to PHYS 048
Principles of operation of semiconductor diodes, bipolar and field-effect transistors, and their application in rectifier, amplifier, waveshaping, and logic circuits. Basic active-circuit theory. Introduction to integrated circuits: the operational amplifier and comparator, to include practical considerations for designing circuits with off-the shelf components. Emphasis on breadth of coverage of low-frequency linear and digital networks, as well as on high order passive and active filter design. Laboratory exercises permit "hands-on" experience in the analysis and design of simple electronic circuits. The course is designed for two populations: a) those desiring a single course in basic electronics, and b) those that need the fundamentals necessary for further study of active circuits and systems.


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Everyday Englis Expressions 2
View more presentations from Parent Toolbox.
Beautiful song for everybody... come on sing it with me...!
On October 2 2009, 60 musicians and celebrities from around the world released a free reworked version to highlight climate change issues ahead of the United Nation's talks in Copenhagen. Singers included Lily Allen, Simon Le Bon from the '80s group Duran Duran and Bob Geldof. The former UN secretary-general Kofi Annan, Archbishop Desmond Tutu and French actress Marion Cotillard also added their voices to the cover version. The song is part of Global Humanitarian Forum tck tck tck time for climate justice campaign and is a part of the greater "TckTckTck" project[3], which aims to draw attention to the urgency of the global warming crisis, by signing a "musical petition" with each download.
The most talked about Prom of the season, however, came from the incandescent young conductor Gustavo Dudamel and the Simón Bolívar Youth Orchestra of Venezuela (Prom 48), whose unreserved joy and exuberance possibly distilled the essence of the Proms. These young musicians demonstrated just how accessible and enjoyable classical music can be, and it was impossible for anyone, from absolute amateur to academic, to resist being swept up in the tumult of exhilaration, and will remain my most enduring of Proms memories.
This is a lecture to explai a little or two importat things in Life... Hope you enjoy it ....
This is another version of Jason Mraz's song.. enjoy!!!


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Posts tagged with 'books'
My perfect holiday
Posted on March 18, 2016, tagged Jill Mansell, You and Me Always, books, getaways, holiday reading, holidays, travel
I wrote a small piece about my new book YOU AND ME, ALWAYS and my ideal getaway for Thomas Cook. I'd love you to take a read here. What's your top holiday destination?


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What will you build
with a box of new tools?
Ideas travel, trends take shape, reputations evolve and people have conversations through the social web.
Here's how Blockwork fits in:
We help people without a lot of time or technology experience understand the potential of social media to engage communities, support collaboration and spread the message.
Focusing on a new set of user-friendly, online tools, blockwork develops affordable strategies to support and improve:
- business & creative processes
- project design & management
- community engagement & participation
- communications & marketing
Got a question? Want to talk? Get in touch.


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Recently, the leadership of the American Academy of Sleep Medicine has called for the development of innovative approaches to better enable the field to meet the challenges of anticipated changes in healthcare delivery, to weather the realities of the current economic climate and tightening cost-containment measures, and to ultimately shift the focus of clinical sleep medicine from an emphasis on diagnostic testing to a model of long-term disease management and improved health outcomes.1 A key element of the proposed "Integrated Sleep Management Delivery Model" involves the requirement for comprehensive sleep centers to obtain three levels of accreditation (AASM Accreditation of Sleep Center, AASM Accreditation of Out of Center Sleep Testing, and AASM Accreditation for Non-Medicare DME Suppliers). This is based on the premise that AASM Accreditation provides a necessary framework or "gold standard" for the delivery and integration of high quality sleep medicine services. In an accompanying recent editorial, Dr. Allan Pack also eloquently argues that in order for the American Academy of Sleep Medicine to "move our field to a new, patient-centered and outcomes-based delivery model," modifications in current accreditation standards are required, encompassing standardized definitions and improved metrics for assessing health outcomes, an emphasis on management of the full range of sleep disorders, and integration of behavioral sleep medicine services.2
While we applaud these developments and enthusiastically support our adult sleep medicine colleagues in moving forward with these important and timely efforts, the absence of any mention whatsoever of the need to establish accreditation standards for children or to develop a similarly comprehensive and integrated approach in the future to the treatment of children with sleep disorders is both striking and highly disappointing to those of us who care for these pediatric sleep patients and their families. On the one hand, the current lack of standardization for conducting pediatric sleep diagnostic services and providing comprehensive evaluation and treatment of pediatric sleep disorders in "mixed" adult and pediatric sleep centers greatly increases the risk of delivery of "second class" or substandard care for children, a situation which is clearly unacceptable. On the other hand, if future accreditation standards for the field of sleep medicine are truly to address the needs of all patients and incorporate a developmental "life cycle" perspective, then neglecting to include the fundamental, unique, and complex needs of children and families in the model is tantamount to a failure to achieve those goals.
Based on this assumption that a "double standard" in the clinical care of adult and pediatric sleep patients currently exists, we propose that the AASM should take the lead in rectifying the situation. We believe that including pediatric standards in the AASM accreditation of sleep centers as a means of achieving parity in the delivery of sleep medicine services is not only necessary and important, but urgent. The specific rationale for this proposal is outlined below:
The AASM 2011 Practice Parameters on Respiratory Indications for PSG in Children3 recommends that all children undergoing adenotonsillectomy for sleep disordered breathing have a diagnostic sleep study to establish the diagnosis and determine severity. Currently, it is estimated that fewer than 10% of children have a sleep study prior to surgery. The practice parameters further recommend that repeat sleep studies be conducted in clinical situations in which residual SDB is likely to be present (e.g., obesity, severe baseline SDB, craniofacial anamolies); the percentage of high risk children currently undergoing postoperative PSG is not known, but likely to be similarly small. In addition, it is anticipated that increased awareness among pediatric healthcare providers of SDB and its potential consequences will result in increased demand.4 As more studies linking pediatric OSAS with adverse behavioral and cognitive outcomes are published and disseminated,5 mental health providers, educators, and parents are also likely to become more active in the referral process. Thus, the potential need for expansion of sleep diagnostic services to appropriately evaluate and treat SDB in children is substantial.
At the same time, we acknowledge that there is clearly a significant "service gap" posed by the relative lack of facilities around the country which provide specialized pediatric sleep medicine services, especially in non-academic and non-urban settings.6 Currently there are only 28 "titled" pediatric sleep centers accredited by the AASM, according to the 2012 AASM Roster of Accredited Sleep Centers. This results in a total of only 1.8% of all accredited sleep centers. Eighty-two percent of accredited sleep disorders centers report accepting children 13 years of age or older. Only 47% of all accredited centers report acceptance of patients 5 years of age or younger and less than one-third of centers will accept children less than 3 years of age.
As portable monitoring increasingly becomes the standard for adults with uncomplicated sleep apnea,1 sleep labs will face increasing competition for inpatients. Given the complexity of conducting sleep studies in children, it is not expected that home studies will also become the standard of care, at least in individuals under 12. The financial incentive for adult labs to study children has also increased due to the recent CPT Editorial Panel approval of increased reimbursement for pediatric sleep studies (age less than 6 years) (http://www.ama-assn.org/resources/doc/cpt/summary-of-panel-actions-feb2012.pdf). While this change is an acknowledgment of such child-specific variables as the increased time and effort required to score and interpret pediatric studies and the need for a high sleep technologist to patient ratio (1:1) in many pediatric patients, it may have the unintended consequence of encouraging unequipped and ill-prepared adult facilities to market their services to the child population.
One probable result of this situation of increased demand and enhanced incentives is that more adult sleep programs will consider expanding their services to include diagnosing and treating children. Recognizing this reality and acknowledging that pediatric sleep centers are currently inadequate in number and geographical distribution to meet the demands, we would argue that the need to establish clear standards for conducting and interpreting pediatric sleep diagnostic tests in non-pediatric settings now is imperative and that incorporation of those standards into accreditation requirements for mixed labs in the near future is mandatory.
In this era of tighter healthcare budgets, increasing scrutiny of health expenditures and uncertainty regarding the future of federal healthcare programs, any perceived unnecessary or wasteful spending for diagnostic procedures will be closely examined and challenged. We contend that pediatric sleep studies which are inappropriately conducted, interpreted, or scored by sleep medicine providers inadequately trained in pediatrics may result in excessive healthcare costs due to the need to repeat studies, delays in treatment, and unnecessary or over-treatment. Requiring specialized pediatric accreditation standards would substantially reduce this risk.
There are a myriad of specific and unique challenges to providing at the very least a minimum standard of diagnostic sleep services for children. First, both healthcare providers and technologists need to posses a knowledge base regarding pediatric respiratory pathophysiology and neurophysiology, normal developmental changes in sleep architecture and cognitive/motor/language/social developmental milestones. Required technical skills in conducting and scoring pediatric sleep studies necessitate initial specialized training, ongoing education, and exposure to an adequate volume of patients. For example, most adult sleep labs have little experience with ETCO2 monitoring, which is considered the standard of care in performing pediatric sleep studies. Sleep staging and respiratory scoring in children in particular, are quite different from those in adults (i.e., sleep architecture findings unique to children such as hypnogogic hypersynchrony, required duration of apneic/hypopneic events,). Moreover, implementation of specific diagnostic procedures such as the multiple sleep latency test, and therapeutic interventions such as PAP therapy in the child population, requires both specialized knowledge and technical expertise, as well as application of principles of behavioral sleep medicine.7
We would argue that many, if not most, sleep centers contemplating expanding their services to include children, as well as some "mixed" labs currently seeing children, do not currently have the knowledge, skill, and expertise to do so. There are a number of reasons for this situation. While ABMS sleep medicine fellowship trained physicians are required spend a minimum percentage of their training seeing children (40 pediatric sleep studies), this may not be sufficient to ensure adequate quality of care, especially for non-pediatric specialties. The relative dearth of specialized pediatric sleep centers available for training sleep medicine fellows also is likely to result in variability in amount and quality of exposure to pediatric sleep medicine across programs. Moreover, non-fellowship trained sleep physicians may have had minimal to no pediatric training. Finally, sleep technologists are not required to have any specific pediatric exposure or to learn appropriate skills during their training.
Therefore, we would propose that a minimum requirement for mandatory training in pediatric sleep medicine for physicians and other healthcare providers and sleep technicians/technologists be developed and included in the AASM accreditation standards for all labs intending to study patients under the age of 16 years. Previously accredited labs would be required to meet these specialized pediatric accreditation standards, including demonstration of pediatric proficiency of technologists in data acquisition and scoring, at the time of re-accreditation.
Conducting sleep studies in children requires specific accommodations to the physical space (sleeping accommodations for parents, cribs), to the emotional and physical needs of children across a range of ages and their caregivers, and the implementation of pediatric-specific procedures to insure comfort and safety.4,8–10 For example, lab hours may need to be extended to accommodate young patients, and age-appropriate toys and books need to be made available. Tours of the lab prior to the testing date should be offered and instructions regarding lab procedures should be sent in advance to families. Recognizing that caregivers are an integral component of pediatric care, sleep programs should have specific policies which provide family-centered and child-friendly care. This is currently not required for accreditation. We contend that minimum standards for the children in the sleep lab environment should be established and child-specific policies and procedures should be included in pediatric accreditation requirements.
While triaging by age is straightforward and feasible, appropriate screening mechanisms to exclude children with significant medical, psychiatric, and neurodevelopmental comorbidities, or children with severe sleep disorders are also needed. Inadequate screening potentially results in poor diagnostic yield and suboptimal care in these special populations and may pose situations which are safety threats. Thus, patient acceptance and referral procedures, and triage parameters and guidelines should be included in pediatric accreditation standards. However, recognizing that, at best, screening procedures are imperfect and that children may present to the sleep lab with unexpected medical, cognitive, or behavioral challenges, the sleep lab personnel, environment, and policies must be prepared to accommodate a wide range of clinical situations. Policies and procedures specific to caring for children with special needs should be included in accreditation standards.
Accreditation of "free-standing" sleep labs, without wrap-around full-service clinical sleep medicine services, is no longer offered by the AASM. Furthermore, no accredited adult sleep lab would be allowed to limit their scope of services solely to testing for sleep disordered breathing. Similarly, accredited sleep labs which provide services to children should not only offer the full range of diagnostic testing and treatment procedures, but also make available the corresponding appropriate follow-up and comprehensive clinical care. Current lab accreditation standards stipulate that no more than 80% of patients referred for sleep testing be direct referrals; this means that at least 20% of pediatric sleep study patients should be accommodated and seen in an affiliated clinical sleep program before or after their sleep study.
A high percentage of children referred to sleep clinics have diagnoses other than sleep disordered breathing, which include behavioral insomnias, RLS/PLMD, partial arousal parasomnias, and circadian rhythm disturbances,11 the evaluation and treatment of which may differ substantially from that for similar diagnostic entities in adults. Moreover, a substantial proportion (up to 40%) of children referred for overnight sleep studies for a suspicion of SDB have at least one, and frequently multiple, additional sleep diagnoses.12 Therefore, a comprehensive evaluation for the range of sleep disorders is a necessary component of standards of care.
Finally, our field is rapidly moving to a conceptualization of sleep disorders as chronic health conditions frequently necessitating long-term care.1 If anything, this paradigm shift is even more salient for children, for whom both the short- and long-term consequences of sleep disorders such as OSAS are often profound and wide-ranging. There is a substantial need for ongoing medical and psychosocial management of chronic sleep disorders in children and adolescents such as narcolepsy or delayed sleep phase disorder in order to prevent poor health and functional outcomes. Conversely, early identification and rapid treatment of sleep disorders such as SDB may result in significantly improved outcomes.5,13
A number of studies have substantiated the observation that primary care pediatricians, medical subspecialists (neurology, pulmonary), and mental health practitioners caring for children are often poorly trained in the diagnosis and management of children with sleep disorders.14,15 Therefore, the assumption that pediatric providers in the community appropriately screen for and refer patients with sleep disorders may be erroneous, and reliance on these providers to subsequently appropriately manage children diagnosed with sleep disorders may be misguided. Therefore, accreditation standards should states that the provision of sleep diagnostic services for children must be accompanied by access to appropriate follow-up care.
There is increasingly compelling evidence for the negative impact of an insufficient quantity and/or quality of sleep on children's physical and mental health, cognitive function, behavior, and academic success,16–20 consequences for which children from racial/ethnic minorities and those living in poverty may be at even higher risk.21,22 There are a large number of cross-sectional and prospective studies which have consistently shown associations between sleep problems and a host of adverse health outcomes in children and adolescents, including increased obesity risk,23 higher rates of motor vehicle accidents24 and accidental injuries,25 adverse cardiovascular outcomes,26 and depression27 and suicidal ideation.28 By mandating accreditation standards for the delivery of sleep services for children, the AASM would be sending a clear message that the field acknowledges the profound impact that sleep disorders have on children's health and recognizes that optimal diagnosis and management of pediatric sleep disorders in the clinical setting represents a key strategy to reduce adverse outcomes. Adoption of pediatric accreditation standards would make practical, real and sustainable progress towards achieving those goals.
Finally, the future of sleep medicine will depend in large part upon the development of innovative approaches to care delivery such as telemedicine, the emergence and validation of new and existing sleep technologies, the development of more sophisticated diagnostic techniques such as biomarkers, and the incorporation into practice settings of tools like clinical registries to assess outcomes and quality of care.29 In order for any of these innovations to be truly progressive and to ultimately have an impact on the health of all Americans, we would contend that the inclusion of the pediatric perspective is both necessary and timely.
This was not an industry supported study. Dr. Owens has consulted for Takeda Pharmaceutical Company Limited, Purdue Pharma, UCB Pharma, Transcept Pharmaceuticals, Inc, and Shire and serves on the advisory boards of Purdue Pharma and Jazz Pharmaceuticals. Dr. Sheldon has received research support from KarmelSonix Ltd. and travel reimbursement from Cadwell Diagnostics. The other author has indicated no financial conflicts of interest.
Owens J; Kothare S, Sheldon S. Pro: "Not just little adults": AASM should require pediatric accreditation for integrated sleep medicine programs serving both children (0-16 years) and adults. J Clin Sleep Med 2012;8(5):473-476.
Collop N, Fleishman S, authors. The future of sleep medicine: Will you be a part of it? J Clin Sleep Med. 2011;7:581–2. [PubMed Central][PubMed]
Pack A, author. Sleep medicine: Strategies for change. J Clin Sleep Med. 2011;7:577–9. [PubMed Central][PubMed]
Aurora R, Zak R, Karippot A, et al., authors. Practice parameters for the respiratory indications for polysomnography in children. Sleep. 2011;34:379–88. [PubMed Central][PubMed]
Zaremba E, Barkey M, Mesa C, Sanniti K, Rosen C, authors. Making polysomnography more "child friendly:" a family-centered care approach. J Clin Sleep Med. 2005;1:189–98. [PubMed]
Bonuck K, Freeman K, Chervin RD, Xu L, authors. Sleep-disordered breathing in a population-based cohort: behavioral outcomes at 4 and 7 years. Pediatrics. 2012;129:e857–65. [PubMed]
Owens J, Mindell J, authors. Pediatric sleep medicine: Priorities for research, patient care, policy and education. J Clin Sleep Med. 2006;2:77–88. [PubMed]
Uong E, Epperson M, Bathon S, Jeffe D, authors. Adherence to nasal positive airway pressure therapy among school-aged children and adolescents with obstructive sleep apnea syndrome. Pediatrics. 2007;120:e1203–11. [PubMed]
Das S, Mindell J, Millet G, et al., authors. Pediatric polysomnography: the patient and family perspective. J Clin Sleep Med. 2011;15:81–7
Beck S, Marcus C, authors. Pediatric polysomnography. Sleep Med Clin. 2009;4:393–406. [PubMed Central][PubMed]
Kothare S, Vendrame M, Sant J, Katz E, D'Ambrosio C, Zarowski M, authors. Fall prevention policies in pediatric sleep-laboratories. J Clin Sleep Med. 2011;7:9–10. [PubMed Central][PubMed]
Meltzer L, Johnson C, Crosette J, Ramos M, Mindell J, authors. Prevalence of diagnosed sleep disorders in pediatric primary care practices. Pediatrics. 2010;125:e1410–8. [PubMed Central][PubMed]
Owens J, Mehlenbeck R, Lee J, King M, authors. Behavioral outcomes in children with sleep disordered breathing: Impact of weight, sleep duration, and co-morbid sleep disorders. Arch Pediatr Adolesc Med. 2008;162:313–21. [PubMed]
Marcus C, Radcliffe J, Konstantinopoulou S, et al., authors. Effects of positive airway pressure therapy on neurobehavioral outcomes in children with obstructive sleep apnea. Am J Respir Crit Care Med. 2012;185:998–1003. [PubMed]
Chervin R, Archbold K, Panahi P, Pituch K, authors. Sleep problems seldom addressed at two general pediatric clinics. Pediatrics. 2001;107:1375–80. [PubMed]
Owens J, author. The practice of pediatric sleep medicine: results of a community survey. Pediatrics. 2001;108:e51[PubMed]
Wolfson A, Carskadon M, authors. Understanding adolescents' sleep patterns and school performance: a critical appraisal. Sleep Med Rev. 2003;7:491–506. [PubMed]
Beebe D, author. Cognitive, behavioral, and functional consequences of inadequate sleep in children and adolescents. Pediatr Clin North Am. 2011;58:649–65. [PubMed Central][PubMed]
Arman A, Ay P, Fis N, et al., authors. Association of sleep duration with socio-economic status and behavioural problems among schoolchildren. Acta Paediatr. 2011;100:420–4. [PubMed]
Gruber R, Laviolette R, Deluca P, Monson E, Cornish K, Carrier J, authors. Short sleep duration is associated with poor performance on IQ measures in healthy school-age children. Sleep Med. 2010;11:289–94. [PubMed]
Feinberg I, Campbell IG, authors. Sleep EEG changes during adolescence: an index of a fundamental brain reorganization. Brain Cogn. 2010;72:56–65. [PubMed]
Nevarez M, Rifas-Shiman S, Kleinman K, Gillman M, Taveras E, authors. Associations of early life risk factors with infant sleep duration. Acad Pediatr. 2010;10:187–93. [PubMed Central][PubMed]
Spilsbury J, Storfer-Isser A, Drotar D, et al., authors. Sleep behavior in an urban US sample of school-aged children. Arch Pediatr Adolesc Med. 2004;158:988–94. [PubMed]
Magee L, Hale L, authors. Longitudinal associations between sleep duration and subsequent weight gain: A systematic review. Sleep Med Rev. 2012;16:231–41. [PubMed]
Vorona R, Szklo-Coxe M, Wu A, Dubik M, Zhao Y, Ware J, authors. Dissimilar teen crash rates in two neighboring southeastern Virginia cities with different high school start times. J Clin Sleep Med. 2011;7:145–51. [PubMed Central][PubMed]
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Gangwisch J, Malaspina D, Babiss L, et al., authors. Short sleep duration as a risk factor for hypercholesterolemia: analyses of the National Longitudinal Study of Adolescent Health. Sleep. 2010;33:956–61. [PubMed Central][PubMed]
Lin J, Tung H, Hsieh Y, Lin F, authors. Interactive effects of delayed bedtime and family-associated factors on depression in elementary school children. Res Dev Disabil. 2011;32:2036–44. [PubMed]
Fitzgerald C, Messias E, Buysse D, authors. Teen sleep and suicidality: results from the youth risk behavior surveys of 2007 and 2009. J Clin Sleep Med. 2011;7:351–6. [PubMed Central][PubMed]
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Cats - Seniors
Ageing and your pet's brain - CDS a form of Dementia in pets
More and more dogs and cats are living well into their senior years and just like elderly humans, pets can suffer from a kind of dementia called cognitive dysfunction syndrome, or CDS . CDS is a
Arthritis in cats
Arthritis or osteoarthritis (to give it its proper name) is a rapidly growing area in feline medicine. Cats are very cunning at hiding illness and pain, as this is seen as a sign of weakness and
Hearing problems in older cats
Around the age of 7-11 years some cats will start to show early signs of ageing such as blindess or deafness.These changes can be a sign that there is a serious underlying medical problem (such as kidney disease or diabetes) but can also just be due to the cat getting older.
How do you keep your best friends around as long as possible?
The answer is early diagnosis and treatment which can be achieved by visiting your veterinarian for twice yearly check-ups. Dogs and cats age much faster than we do and as a result, health problems progress much more rapidly.
How do you know if an older pet is unwell?
Observe the early warning signs of age related disease and discuss them with your veterinarian, be on the look out for weight loss or gain, change in appetite, inappropriate urination, confusion, coughing, difficulty moving, lumps or bumps ....
How long do cats live? Ageing and your feline
Cats are living longer than ever. With improvements in nutrition and veterinary medicine including vaccines and therapeutic agents, cats are living to over 15 years of age and in some cases over 20
How much exercise does your senior pet need?
You may need to adjust the frequency and intensity of your daily exercise regime as a pet ages but it is important to maintain a regular exercise program. If your pet doesn't use their muscles, and move freely on a regular basis, they will lose muscle mass and tone.
How to keep your senior pet comfortable
Our pets don't realise that they are getting old, unlike us their grey beards don't cause them concern. They don't understand the reasons why they can't run as fast anymore or why they can't race you
Hyperthyroidism in Cats
Hyperthyroidism is a common disease affecting middle age and older cats. It is caused by an increase in production of thyroid hormones (known as T3 and T4) from enlarged thyroid glands in the cat's neck.
Keeping away the Winter Blues in Pets
Hibernation season is upon us! As the temperature outside is dropping, all we can think about is getting cosy with our favourite winter blanket, a nice cup of tea and staying as close to the heater as possible.
Lumps and bumps on your pet's skin
Although most lumps are harmless it is impossible to tell what sort of lump you are looking at. There are many different things that can cause swellings - bruising or fluid build-up, abscesses, things attached to the skin (eg. small parasites) and, of course, cancers.
Managing pain in pets
Suffering in silence is something we all know too well when it comes to our pets and their pain management. One of the most common issues vets and vet nurses face in clinic, is fur-parents having
Now your pet is a senior, what changes do you need to make?
Tips on things you can do to make your older pet's life easier such as changes to diet, dental care, exercise and environment
Senior cat care - an overview
Old age itself is not a disease but we are aware that certain diseases can be age related. Some of the medical conditions that can affect cats such as kidney and heart disease, diabetes and high
Seniors Health Checks: Vital for the silver foxes
Our fur-babies developing that silver fox beard can be a significantly fulfilling moment in our lives. However, it is also an important wake-up call.
Top tips to keep our grandpets snug and cosy
Our grandpets; mature, worldly and the best cuddle buddies we will ever have the joy of meeting. However, what comes with this mature age, is a lot of extra TLC.
What should you feed your senior pet?
Senior pets require a special diet with fewer calories, less protein and phosphorus. We recommend premium pet foods specifically formulated for senior pets.
When is a pet considered to be a senior?
Pets age much faster than people do, and their rate of ageing depends not only on the species type but also on the size of the breed. Cats are generally less than 10kg and are considered senior