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|Solution Number:
|Using symmetries in COMSOL Multiphysics
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|symmetry plane axis rotation reflection translation rotoflection rototranslation
Problem Description
How do I take advantage of the symmetries in my COMSOL model?
Using Symmetries to Reduce Model Size
By using symmetries in a model you can reduce its size by one-half or more, making this an efficient tool for solving large problems. This applies to the cases where the geometries and modeling assumptions include symmetries. The most important types of symmetries are axial symmetry and symmetry and antisymmetry planes or lines.
- Axial Symmetry is common for cylindrical and similar 3D geometries. If the geometry is axisymmetric, there are variations in the radial (r) and vertical (z) direction only and not in the angular () direction. You can then solve a 2D problem in the rz-plane instead of the full 3D model, which can save considerable memory and computation time. Many COMSOL Multiphysics physics interfaces are available in axisymmetric versions and take the axial symmetry into account.
- Symmetry and Antisymmetry Planes or Lines are common in both 2D and 3D models. Symmetry means that a model is identical on either side of a dividing line or plane. For a scalar field, the normal flux is zero across the symmetry line. In structural mechanics, the symmetry conditions are different. Antisymmetry means that the loading of a model is oppositely balanced on either side of a dividing line or plane. For a scalar field, the dependent variable is 0 along the antisymmetry plane or line. Structural mechanics applications have other antisymmetry conditions. Many physics interfaces have symmetry conditions directly available as features.
To take advantage of symmetry planes and symmetry lines, all of the geometry, material properties, and boundary conditions must be symmetric, and any loads or sources must be symmetric or antisymmetric. You can then build a model of the symmetric portion, which can be half, a quarter, or an eighth of the full geometry, and apply the appropriate symmetry (or antisymmetry) boundary conditions.
Thermal Contact Resistance Between an Electronic Package and a Heat Sink example with symmetry planes indicated as grey workplanes. Only one sixteenth of the model geometry is used for computing the solution.
For an example of using a symmetry plane in Fluid Dynamics and Heat Transfer, see the model Free Convection.
The above shown model Thermal Contact Resistance Between an Electronic Package and a Heat Sink is available among the Heat Transfer Module examples.
For an example of high-frequency electromagnetic applications with symmetry planes, see the model Microwave Oven from the RF Module.
The model Muffler with Perforates, available in the Acoustics Module, simulates a car muffler with perforated baffles and pipes for a range of frequencies.
Possible Pitfalls
In structural mechanics there are some cases when the results are not purely symmetric even though the problem at first may look so.
- Eigenfrequencies in symmetric structures can be both symmetric and antisymmetric. You need to do two studies of half the geometry, one with each set of boundary conditions, in order to capture all the eigenfrequencies. If there are multiple symmetries (like modeling a quarter of a structure) all permutations of boundary conditions must be considered.
- In linearized buckling analysis, the lowest buckling mode of a symmetric structure can in the same way be either symmetric or antisymmetric.
- Axial symmetry can only be used to find axially symmetric eigenmodes in the case of eigenvalue analysis (eigenfrequency or buckling).
- Antisymmetric boundary conditions are generally not compatible with geometrically non-linear analysis of solids since the constraint will remove some strain terms necessary to describe a finite rotation at the
antisymmetry section.
Find More Information
For more tips on efficient modeling practices, see COMSOL Multiphysics Reference Manual, in the section Modeling Guidelines.
COMSOL makes every reasonable effort to verify the information you view on this page. Resources and documents are provided for your information only, and COMSOL makes no explicit or implied claims to their validity. COMSOL does not assume any legal liability for the accuracy of the data disclosed. Any trademarks referenced in this document are the property of their respective owners. Consult your product manuals for complete trademark details.


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A Chicago police officer has been indicted on federal civil rights charges after dashcam video captured him firing in to a car packed with teenagers, wounding two, as it backed away from him.
Marco Proano, 41, was charged with two counts of deprivation of rights under color of law, according to U.S. Attorney for the Northern District of Illinois Zach Fardon.
Proano is accused of using unreasonable force with a dangerous weapon while on duty in Chicago on Dec. 22, 2013.
U.S. & World
The incident was captured on the officer's dashcam video and the footage first released to the Chicago Reporter last year by a retired Cook County judge who called it "disturbing on a whole different level."
In the nearly three minute video, Proano arrives at 95th and South LaSalle streets where a vehicle had been stopped by two other officers and is seen approaching the vehicle with his gun pointed sideways. When the driver of the vehicle backs away from the officers, Proano raises his gun and opens fire.
Six black teens were inside the vehicle, and two of the teens were wounded in the shooting.
"When a police officer uses unreasonable force, it has a harmful effect on not only the victims, but also the public, who lose faith and confidence in law enforcement," Fardon said in a statement. "Our office will continue to independently and vigorously pursue civil rights prosecutions to hold officers accountable and strengthen trust in the police."
At the time of the video's release, Chicago police said the officer involved in the shooting was moved off the street and assigned to desk duty. The investigation was then referred to state and federal authorities.
"The charges announced today are serious and the Chicago Police Department will have zero tolerance for proven misconduct," CPD said in a statement Friday. "Mr. Proano was relieved of his police powers last year during the course of IPRA's investigation and CPD is fully cooperating with the US Attorney's Office."
A lawsuit filed by the mothers of three teens injured in the incident, including the two who were shot, alleges Proano fired more than a dozen rounds into the vehicle, striking one teen in the shoulder and another in the hip and heel.
The suit claims the teens did not show a weapon or pose any apparent threat, and alleges police removed the injured teens from hospitals without authorization to take them to a police station for questioning.
In a separate court filing, Proano reportedly admitted to the shooting, but denies claims that the teens did not show a weapon.
The Independent Police Review Authority said last year it referred the case to prosecutors shortly after the shooting took place.
"At the time of the incident, Officer Proano was removed from his District of assignment and placed on desk duty at Public Safety Headquarters," the organization said in a statement. "The incident remains under investigation by federal authorities and IPRA."
Chicago police also said that early last year, former police Supt. Garry McCarthy changed the department's policy to clarify that officers are "prevented from firing at or into a moving vehicle when the vehicle is the only force used against the sworn member or another person."
Each count of the indictment carries a sentence of up to 10 years in prison.

subset: commoncrawl


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If my sharpie collection is any indication, markers are something that you never outgrow. (My teenage self would approve!) This Sharpie-dyed doily tote bag tutorial from Vicki at The Creative Goddess serves as a lovely reminder of just how versatile a tool your markers can be. Who'd have thought that permanent markers plus a little rubbing alcohol would make such a gorgeous and easy dye method? It's like faux tie-dye, but with way more control over the resulting design!
How-To: Sharpie-Dyed Doily Tote Bag


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Location: Guilford Seniors Village
Reporting to the General Manager and/or Director of Care, the Registered Nurse is the role model
and team leader who coordinates and supervises the activities and duties of those who deliver
direct resident care. The Registered Nurse performs duties and monitors departmental activities
in accordance with established standards, regulations, policies and procedures to maximize
resident focused care while maintaining resident respect and dignity.
Include but not limited to;
1. Assess residents' needs and record in the Care Management system; plans, implements and
evaluates resident care.
2. Coordinates and supervises care staff; directs their work and assigns duties as necessary to
ensure focused resident care is provided and resident rights are observed.
3. Liaises with physicians, community agency representatives, families, visitors and volunteers.
4. Administers medications and treatments as per established standards, regulations, policies
and procedures.
5. Provides direct care to residents as necessary to ensure quality resident focused care.
6. Ensures equipment and supplies are stored and maintained as per policy and procedures.
Reports unsafe or faulty equipment to appropriate manager.
7. Maintains paper and electronic documents as per established standards, regulations, policies
and procedures, ensuring confidentiality is maintained as per policies.
8. Liaises with other disciplines and departments to ensure quality focused resident care.
9. Participates in orientation of new employees.
10. Provides work direction to other care staff and provides informed input into staff evaluations.
11. Actively participates in facility programs, meetings, committees and educational inservices
12. Maintains an up to date knowledge of facility policies and procedures, particularly those
concerning the administration and recording of medications, safety and emergency
procedures and appropriate aseptic techniques.
13. Encourages and adheres to a holistic philosophy of wellness, recognizing that each individual
is capable of, to varying degrees; making decisions about his/her life and is a partner in the
14. Maintains a safe environment for clients/family unit and staff, through
(a) accident prevention,
(b) knowledge of emergency procedures and regulations,
(c) using skills, physical facilities, supplies and equipment safely and appropriately, and
(d) utilizing infection control procedures.
15. Performs other related duties as required
1. Graduate of an approved school of nursing, current active registration with the BC College of
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2. Additional training and previous experience in the care of the frail elderly and physically and
mentally handicapped persons.
3. Valid First Aid Certificate
1. Ability to communicate effectively verbally and in writing in the English language.
2. Must be in good health and free from communicable diseases, physically able to perform
repetitive tasks, lift, squat, bend, stand and walking as required to perform the duties of
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3. Must be in good health, physically able to perform repetitive tasks, lift, squat, bend,
stand and walk as required to perform the duties of the position.
Job Type: Casual
Salary: $32.75 to $40.44 /hour


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M23 rebels vow to take Congo, as troops defect
GOMA, Congo (AP) — Pressing ahead with their seizure of cities in mineral-rich eastern Congo, the M23 rebels said Wednesday they are fighting to control all of this sprawling country and to topple President Joseph Kabila's government.
Following their capture of the strategic city of Goma a day earlier, the rebels took the nearby town of Sake on Wednesday as they moved toward the provincial capital of Bukavu.
"Kabila has to go. We want our country back," said M23 Col. Vianney Kazarama to cheers from thousands gathered at the Goma stadium. "We are now going to Kinshasa. No one will divide this country."
Nearly 3,000 Congolese army soldiers and police defected to the rebels in Goma on Wednesday and turned in their weapons at the stadium rally.
Even as the M23 rebels consolidated their gains, the presidents of Congo, Rwanda and Uganda called on them to give up the territory they now control.
The M23 is made up of hundreds of officers who deserted the Congo army in April this year. Neighboring Rwanda has supplied soldiers and equipped the rebels with sophisticated arms, including night vision goggles and 120 mm mortars, according to a report by United Nations experts to be published Friday.
The U.N. report accuses the rebels of grave human rights abuses included murder, rape and the use of child soldiers.
The M23 is largely made up of ethnic Tutsis who want to extend their control over eastern Congo and its valuable deposits of gold, copper, coltan and timber. Their campaign, and alleged support from Rwanda, has its roots in the 1994 genocide in which some 800,000 Tutsis were massacred by Hutus.
Since then eastern Congo has been plundered by several rebel forces and foreign armies in conflicts that killed millions of people.
The speed with which the M23 has seized Goma and the surrounding countryside exposes the weakness of Kabila's government, 1,500 kilometers (978 miles) to the west in Kinshasa, experts said.
"It's a setback for Kabila. He wasn't even capable of reforming the army and the fall of Goma demonstrated that," said Felix Bafilemba, a Goma-based analyst for the Enough Project. "It marks the beginning of the end for Kabila's regime."
Strewn with bodies, burned out vehicles and abandoned tanks, the road between Goma and Sake showed evidence of Tuesday's fighting.
M23 soldiers in vehicles patrolled the streets of Sake, 27 kilometers (17 miles) south of Goma. As in Goma, most residents accepted the rebels' presence.
"We only want peace," said Innocent Rumabo in Sake.
Other resident complained of rapes carried out Tuesday night.
"I know two women who were raped, there are more in the area," said one Goma resident who insisted on anonymity for fear of retaliation.
In neighboring Uganda, the presidents of Uganda, Rwanda and Congo resolved to put pressure on the M23 rebels to give up territory they have captured, according to a statement released at the end of the emergency talks.
"Even if there are legitimate grievances by the mutineering group known as M23, they cannot accept the expansion of this war or entertain the idea of overthrowing the legitimate government of (Congo) or undermining its authority," said presidents Joseph Kabila of Congo, Paul Kagame of Rwanda and Yoweri Museveni of Uganda, in a statement issued late Wednesday.
"Therefore the M23 must immediately stop this offensive and pull out of Goma," said the presidents' statement issued in Kampala. This resolution was to be immediately communicated to the M23 leadership, the statement said.
Behind the statement, there was considerable bargaining in the emergency summit, according to diplomats. Congo's Kabila made a concession by agreeing to negotiate directly with the M23, a reversal from his previous refusal to talk with the rebels.
For his part, Kagame publicly supported Kabila and reiterated his denial that Rwanda is supporting the rebels. But U.N. experts say the evidence is overwhelming that Kagame is supporting, even directing, the M23 so that tiny Rwanda can control eastern Congo's lucrative mineral trade.
Uganda, which was also implicated in the Congo violence by report of U.N. experts, denies supporting the rebels but Museveni is increasingly seen as an ally of Rwanda's Kagame.
While the three presidents called on the M23 to give up the territory that they have seized, the rebels continued Wednesday on toward their next target: Bukavu, the capital of South Kivu province on Lake Kivu.
The Congo soldiers remaining in the government army near Goma said they are not sure what to do.
"We are waiting for orders now. We don't know what we are supposed to do. It's hard. My comrades who defected in Goma, we're going to fight them," said a Congolese army major reached by phone in Kanyabayonga, northwest of Goma, where some of the troops have regrouped. The major required anonymity because of the uncertain situation.
The U.N. has its largest peacekeeping force in the world in Congo, with 18,000 troops, known by their acronym MONUSCO. But the 1,500 peacekeepers in Goma did not help the Congo government troops forces during Tuesday's battle because they do not have a mandate to engage the rebels, said Congolese military spokesman Olivier Hamuli, who expressed frustration over the lack of action by the peacekeepers.
A U.N. spokesman in New York said the peacekeepers in Goma held their fire to avoid triggering a battle.
On Wednesday, the Security Council was expected to review the mandate of the U.N. peacekeeping force in Congo. A resolution adopted Tuesday by the Security Council asks the U.N. secretary-general to recommend possible redeployment, and possible "additional force multipliers."
The resolution approved unanimously by the council imposes targeted sanctions, including a travel ban and assets freeze on the M23 rebel group leadership. But it did not name two countries accused by Congo of supporting the rebels: Rwanda and Uganda.
The council demanded that the M23 rebels withdraw from Goma, disarm and disband, and insisted on the restoration of the crumbing Congolese government authority in the country's turbulent east.
Associated Press reporter Rodney Muhumuza in Kampala, Uganda contributed to this report.
Copyright 2012 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


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By Krista Smith, Vanity Fair
The ever lovable Diane Keaton has kept herself quite busy in the past year, publishing her memoir Then Again last November, shooting her upcoming film The Big Wedding, and now partnering with Audible.com to read from Joan Didion's Slouching Towards Bethlehem. V.F.'s West Coast editor, Krista Smith, caught up with the iconic actress to discuss what Didion's work meant to her as a twentysomething Californian, her love of hip-hop, and getting to know Robert De Niro. Highlights from their chat:
Krista Smith: What was it like reading Joan Didion's Slouching Towards Bethlehem aloud?
Diane Keaton: For me, talking out loud--that's what I do. I use other people's words, and I speak their words. I loved being able to do that because it gave me a whole different slant on it. I like to hear myself say the words, and then I feel more intimate with the words. She's such a great writer. The things that she talks about in her books, particularly in Slouching Towards Bethlehem, are very powerful. She talks about self-respect.
I read this one paragraph:
"To live without self-respect is to lie awake some night, beyond the reach of warm milk, the Phenobarbital, (that's how long ago it was) and the sleeping hand on the coverlet, counting up the sins of commissions and omission, the trusts betrayed, the promises subtly broken, the gifts irrevocably wasted through sloth or cowardice, or carelessness. However long we postpone it, we eventually lie down alone in that notoriously uncomfortable bed, the one we make ourselves. Whether or not we sleep in it depends, of course, on whether or not we respect ourselves."
That to me is something that we've all felt and we all push aside. In the course of waking up and facing life, we fall back. To be reminded and to speak of that, is really amazing.
You're both California girls. The book had to have been huge for you at the time it came out.
I was in my early 20s, and it was. Then I thought what would it be like to read it again--you know, to see how I feel about it. I felt even stronger when I read it. The way she talks about California and the Santa Ana winds, which I grew up with. It will always be there. In some part of my own personal history, she lingers and she'll never really go away. That's how I define my experience and the romance I feel about California as well as all its horrible flaws. This is a woman who is just really a brilliant writer. Reading her and speaking her words resonates.
How does the actual process of recording an audio book work?
It takes approximately three days and you just keep going over it. They were good enough to let me say it the way I wanted to say it. That may not be what Joan Didion would like to hear. It's a very personal feeling to have somebody saying your words out loud and you're not speaking them. I don't know if she "speaks" her words out loud. I wrote a book and I kept re-editing it by speaking out loud, because that's what I'm familiar with: being a performer, or whatever I am.
What are you listening to these days? Any audio books?
The kind of music I listen to is when I'm walking, because I walk all over the neighborhoods of Los Angeles. How else am I going to see it? If I don't drive, I take the dog and I listen to something. Right now I love the new Frank Ocean CD, Channel Orange. It's just amazing music. I also like the Jay-Z album with Kanye West. The last one--the Throne album. I just think that's so astonishingly beautiful, the way they orchestrate it. That's how I got to know who Frank Ocean was. Frank Ocean sang on one of the cuts. He [is] very orchestral in a weird way.
The last book I listened to was Nora Ephron's. She was so present and she had such a great delivery. Just the way she said her words. I kept thinking, Does she speak her words out loud when she's writing too? Does she edit by listening too?She's a natural. She's so gifted. And funny. And also very moving with this particular book, particularly at the end when she talks about her dear friend dying and her response to death. She should not have died. It doesn't make sense. This is a woman who isn't supposed to die at age 71. There was so much more for her to do. She was so creative. She was a dynamic force. She was strong. She was powerful. The sudden news of her passing was kind of like a shock because, on many levels, but on one level as well, that level which I don't think has been stressed much is that, it could be you.
What was it like working with Robert De Niro in The Big Wedding?
Mr. Robert De Niro. My god. A legend and also a dear man. He's very kind. It's like, oh, he's so kind. Why is he so kind? And he's quiet. But he's a lovely man. I really like him. He loves his family. You don't think of him that way when you only know him from a distance. I did a movie with him called Marvin's Room a long time ago, but he was a producer. I didn't really know him and he was intimidating to me. But things change.
More from Vanity Fair:
The 2012 Vanity Fair International Best Dressed List
Kristen Stewart Gets Glamorous for Vanity Fair
Lady Gaga, Angelina Jolie and Jennifer Aniston: Vanity Fair's Classic Nude Portraits
5 Things You Don't Know About Kate Middleton


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The Globe
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The information is derived from those websites which are being browsed most in the United States of America. (The websites concerned with the individual sports are taken into consideration). The list shows which sports the people of a specific country watch and not necessarily the sports they play.
10 #1. Football
In America the term "Football" is basically used for the American Football. The competitions of the highest levels are organized under the NFL (the National Football League). It is particularly popular in specific areas of the United States which include the Southern areas (Texas, Florida) and the Western Areas (California).
9 #2 Baseball
Also known as the national pastime of the United States, Baseball is the most popular sport in the country. Speaking broadly there are two levels of competitions – the minor league baseball and the major league baseball or MLB. These league competitions are not only watched in the US but also around the world over.
8 #3 Basketball
After the baseball and the American Football the next most closely followed game in the United States is Basketball. The NBA (National Basketball Association), just like the MLB and the NFL are not only being watched in the US but are popular around the world. It is mostly popular in the eastern and the northern regions of the United States.
7 #4 Hockey
It is among the most popular sports in the US.
6 #5 Soccer
America is one of those very few countries where Soccer does not hold the top position in terms of popularity. Soccer is regarded as the most popular sports in the world in terms of viewership and participation although it is not that much popular in the US. However it is gaining popularity in the school based programs as about 380,000 boys and 340,000 girls participated in it during the 2008 as per the U.S Census.
5 #6 Golf
Golf is the sixth when it comes to popularity in the USA as Tiger Woods is the most popular Golfing athlete presently.
4 #7 Tennis
Next in line comes Tennis or Lawn Tennis. In this sport the US also has a great record.
3 #8 Motorsports
The Motorsports including auto-car and the motorcycle racing come next line in terms of it's following among the people in the United States.
2 #9 Pro Wrestling
Wrestling comes next as the most popular in the United States.
1 #10 Martial Arts
The youngsters in the US are developing liking for the marital arts and that is why it has crept into the top 10 most popular sports in the United States.


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Android Malware Spikes in 2012
According to McAfee the number of malicious Android apps surged from the hundreds to the thousands in the first quarter of 2012, compared to the same period last year.
In "McAfee Threats Report: First Quarter 2012" the company reported that the number of mobile threats on Android reached 7,000 samples, while Symbian, Java ME (mobile edition), and "others" combined reached only 1,000.
Adam Wosotowsky, messaging data architect at McAfee Labs, attributed at least half of the newly detected malware to McAfee's better detection methods, such as identifying more third party app stores and improving its scanning technology. Even taking this into consideration, he estimates Android malware has "definitely more than doubled" since the same time last year.
Not the "Year of Android Malware" Yet...
The figures are alarming, but it's still fairly easy to keep your Android devices clean of malware. For starters, steer clear of third-party app stores (outside Google Play or Amazon App Store for Android). Unlike in the PC environment where worms can spread without any user involvement, mobile infections still rely on users installing malicious apps. Most Android malware still originates from and targets users in China and Russia, and gets distributed through non-official app stores.
However, attackers are becoming more sophisticated in their methods. In early May, Lookout Mobile Security reported a primitive sort of drive-by download, where attackers used compromised websites to trick Android users into installing the "NotCompatible" Trojan. When a user visited a compromised website, the malicious app would automatically begin downloading. However a user would still be prompted to install the app before it could exploit anything.
McAfee also found "significant amounts" of new adware, which even security-conscious Android owners can catch from official app stores.
Mobile adware refers to code within ad networks that can access more data perform more functions on your device than you're probably aware of. For example in January, vendors Symantec and Lookout squabbled over the the shade of grey of one particularly aggressive ad network being used to monetize free Android apps. Symantec initially identified it as malware called "Android.Counterclank," but hours later, Lookout Mobile Security said the SDK in question was really an aggressive ad network called "Apperhand" that placed a search icon on your mobile desktop without your permission, and pushed ads through the notice bar.
Google Play doesn't block adware (after all it runs one of the most ubiquitous ad networks, AdMob) which can be a bigger problem for Android owners.
Fortunately, many vendors now offer ad network detectors that explain what the ad network dropped in your Angry Birds Lite can do. Check out Lookout Ad Network Detector or TrustGo Ad Detector for such tools.
As far as mobile security suites go, Lookout for Android is PCMag's Editors' Choice for Android security, but other high-performing malware detectors include F-Secure Mobile Security 7.6 and McAfee Mobile Security 2.0. All have free versions that include a quick malware scan.


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Global Equity Allocation Strategy
The Active International Allocation (AIA) Team believes that the key determination of successful investment in global equity markets is the choice of region, country and/or sectors, and industry. They believe an active top-down approach can consistently add value by overweighting regions, countries, sectors and industries, which have positive dynamics, unrecognized value, and supportive technical factors. The team's goal is to overweight markets and sectors where it believes there is positive fundamental change that has not yet been discounted by the market.
The team's approach emphasizes these macro decisions rather than thousands of individual securities. It believes that macro investment factors can be just as potent as bottom-up investment factors and seeks to exploit the fact that most money managers look at stocks and analyze individual corporate managements. Though this method can be attractive, the team thinks that corporate managements and stocks will be impacted by economic growth, policy decision-makers and overall moves in investor sentiment. This perspective offers clients a diversified way of investing—not just a diversified portfolio.
A diversified way of investing—not just a diversified portfolio
Complementing the more widely available bottom-up, core investment capabilities, the top-down approach of the GEA investment program focuses on adding value by overweighting regions, countries, sectors and industries which the team believes have positive dynamics, unrecognized value and supportive technical factors.
Long tenure of product and investment team
Lead Portfolio Manager, Ann Thivierge, has been managing the AIA strategy since 1995, and joined Morgan Stanley in 1986.
Rigorous, flexible and continuously evolving quantitative and qualitative analyses
The team has enhanced the measurement of valuation and fundamental analysis across regions, countries, sectors and industries. For example, they added factors to compare and analyze profitability and operating leverage, and developed factors that allow them to describe quality of earnings and balance sheet health. They also added various factors that help to describe the differences in fundamental macro operating environments across countries and regions. The enhanced framework readily allows the team to highlight opportunities to be further analyzed through fundamental research.
The catalyst for market performance can be marginal changes in economic, corporate and political environments. The AIA team gains market insight by visiting countries, meeting with central bankers, government officials, strategists, and economists, and analyzing both internal and external research to form investment opinions. Filtering through information, analyzing and monitoring macroeconomic cycles, political and social dynamics, business and regulatory environments, earnings and corporate trends are key determinants in the formation of investment decisions. In addition, the critical factors in the team's fundamental country and sector analyses are the outlook for economic growth, interest rates, corporate earnings and monetary and fiscal policy. In particular, the team searches for incremental shifts in policy or the operating environment, which they believe will impact profitability.
Valuations are the core of the team's decision-making process as the team invests in undervalued countries and sectors. The team analyzes and monitors relative and absolute valuation relative to long-term historical data across asset classes, regions, countries and sectors. The team then ranks the markets and sectors/industries on relative attractiveness and consistently examines ranking changes.
Overall market sentiment of particular countries and sectors/industries can be an important indicator of risk and return. The team consistently monitors global investor sentiment indicators, global fund manager asset allocation and equity positioning, and cross- and intra-asset global portfolio flows. At extremes, sentiment indicators can sometimes be useful contrarian indicators or a signal to increase or reduce portfolio positions. The team prefers to be contrarian but has a healthy respect for momentum.
Portfolio Implementation
To implement investment decisions, the team builds baskets of stocks selected by a risk model, which does not factor in bottom-up analysis of names and is designed to broadly track country or sector/industry performance. The team invests in a diversified selection of stocks in the country, sector or industry.


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Have you or someone you know spent years cultivating an Alliance-side guild in World of Warcraft, only to realize late in the game that Blizzard only loves the Horde? Now's your chance to feel the company's approving warmth as new services debut that allow guild leaders to change realm and faction.
Starting yesterday, guild leaders on select World of Warcraft servers have the opportunity to buy their way into the other side, take their guild to another server, or just change the name now that the pun you thought was hilarious five years ago has grown stale, like Blood, Bath, and Beyond (only kidding, that one never gets old).
Of course Alliance and deviant Horde guild masters must pay for their trespasses. Initiating a guild faction change will run $40, changing realms $35, and a guild name change runs $20. Bundling a realm change and a faction change together scores a $5 discount ($65), and both of the pricier services come with a free name change.
Now keep in mind that all that is transferring for these prices is the guild master, the guild bank, level, perks, and achievements. Everything else, and by that I mean other guild members, will have to pay for their own ticket to wherever the guild goes. When the guild leader leaves those left behind will be in a level one guild of the same name, stripped of all its worth.
So be really nice to your guild leaders.
The service is currently being implemented only on select realms, with plans to roll it out wide in the coming weeks.
And I was just kidding; Blizzard loves the Horde and Alliance equally. They just love the Horde more equally.
New Guild Services Now Available [World of Warcraft]
You can contact Michael Fahey, the author of this post, at email@example.com. You can also find him on Twitter, Facebook, and lurking around our #tips page.


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Petersen Museum uses DUSTOP Custom Indoor Covers by Covercraft
The world-reknowned Petersen Automotive Museum in Los Angeles can display only a portion of their vast collection at any given time. Hundreds of fabulous classic cars are kept in storage when not on display, and managing vehicle storage is a never-ending job.
Museum Collection Manager Tom Kenney says, "In our outer perimeter storage areas, where the environment is less than pristine, we use covers to keep dust, greasy air, and particulate matter (from exhausts and general environmental fallout) from settling on the finishes. In the past, we've relied on the softness of a flannel-type cover, but found that very fine dust particles pass through that fabric and onto the car. After several weeks, the car gets dirty under the cover so, when you remove it, you're actually pulling a very fine, abrasive layer of dust across the car's surface. Some of our cars sit for months, so the accumulated dirt becomes a serious issue. Also, it's not just the paint that gets soiled, but the chrome and other plated parts begin to "bloom" because of the contaminants in the environment. We also use car covers at car shows/concours, as more show organizers are requesting that participating vehicles be placed on the show field the day before the show. Again, contaminants from the air, trees, birds, etc., can affect our car, and overnight moisture from the ground causes other issues with the car's cosmetics. A good cover minimizes the risk of damage."
Covercraft suggested DUSTOP(tm) for this task, as its 4-layer non-woven construction is specifically designed to assure that any car it covers will be as clean when it is uncovered as it was when rotated into storage. DUSTOP's outer layer is tough, yet still relatively soft, and underneath it are breathable layers of material designed to keep out dust, dirt, and airborne chemical fallout. The inner-most layer is super-soft high-loft spunbond, to pamper and protect the car's paint and plated surfaces. DUSTOP's four layers combine to create a bit of a cushion, helping resist minor dings and dents as museum staff and equipment circulate around the covered cars.
Covercraft currently has over 80,000 patterns in their library, but some of Petersen's exotic vehicles, like the one-off Jonckheere-bodied 1925 Rolls-Royce Phantom I Aerodynamic Coupe, required special pattern measuring, an easy task using Covercraft's dimension sheet which specifies all the required measurements.
The Petersen Automotive Museum: www.petersen.org
Covercraft: www.covercraft.com / 800-426-8377 / firstname.lastname@example.com


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Ruby on Rails For Dummies
Table of Contents
Author Information
Related Websites
Use this free and easy programming language for e-commerce sites and blogs
If you need to build Web and database applications quickly but you don't dream in computer code, take heart! Ruby on Rails was created for you, and this book will have you up and running in no time. The Ruby scripting language and the Rails framework let you create full-featured Web applications fast. It's even fun!
Discover how to
- Install and run Ruby and Rails
- Use the RadRails IDE
- Create a blog with Ruby
- Connect your Web site to a database
- Build a shopping cart
- Explore Ruby's syntax


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MILTON, Mass. – Sophomore Patrick Dayton (Archer City, Texas) led off the game with a home run to ignite a MIT offense that scored runs in each of the first four innings, enabling the Engineers to pick up a 10-5 baseball win over Curry College. It was the third straight win for MIT, which improved to 8-7 with the non-conference victory. Curry fell to 5-10 with the loss.
After Dayton's blast to start the game, MIT went on to plate two more runs for an early 3-0 lead. After senior Bryan Macomber (Los Altos, Calif.) reached on a fielder's choice play, he moved to second on a failed pick off and then came around to score on a fielding error by the Curry second baseman on sophomore Creed Mangrum's (Sandy, Utah) ground ball. Mangrum would move up to third on a pair of wild pitches before coming in to score on freshman Hayden Cornwell's (Newport Beach, Calif.) ground out.
MIT scored twice more in the second, getting an RBI single off the bat of senior Torre Swanson (Redding, Calif.) and a sac fly from junior James McKinney (Wakefield, R.I.). The Engineers then went on to stretch their lead to 7-1 after scoring single runs in the third and fourth innings on a sac fly from junior Grant Iwamoto (Aiea, Hawaii) and an RBI single from Macomber.
MIT starter, freshman K.J. Parent (Knoxville, Tenn.), was in control during his six innings on the mound. He allowed just one run in the second when Curry senior David Stevens (Deerfield Beach, Fla.) led off with a single, moved to second on a wild pitch, and then came around to score on a single by freshman Matt Warren (Wilbraham, Mass.). Parent allowed just two more hits after that, finishing with five hits and just the one run allowed, striking out three on his way to the win.
Curry rallied in the seventh, seeing its first three hitters reach on walks. After one run scored on a wild pitch, Junior Matt Rodriguez (Quincy, Mass.) doubled home a pair of runs to make it 7-4. One out later sophomore Kyle Connors (Stoughton, Mass.) singled in Rodriguez to cut the MIT lead to two.
MIT answered with three more in the top of the eighth to put the game away. An error, a walk and a hit batter loaded the bases with one down for Macomber, who singled to center to bring home a pair. Next up was Mangrum, who promptly brought Macomber around with a double to left. The duo combined to go 5-for-9, accounting for five RBIs and three runs. Cornwell, Swanson and freshman Eben Bitonte (Wichita, Kan.) all added a pair of hits for the Engineers.
MIT returns to NEWMAC conference action in its next game as the Engineers play host to the U.S. Coast Guard Academy on Friday at 3:30 p.m. Curry will play again at home tomorrow when the Colonels host Fitchburg State at 3:30 p.m.


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The days when junior doctors could go on strike in protest at changes to their contracts have been announced.
Subject to a strike ballot, a 24-hour walk-out from 8am on December 1 would involve all junior doctors except those who are on call to provide emergency cover.
Then two full strikes are planned from 8am-5pm on Tuesday, December 8, and from 8am-5pm Wednesday, December 16.
The British Medical Association (BMA) said it had taken the "extraordinary" step of announcing strike dates before the ballot closes on November 18 to minimise the impact on patients.
In an e-mail to BMA members in England, chairman Mark Porter said: "We are releasing this information at this early stage because we want to give as much notice as possible.
"It sounds like an oxymoron when talking about industrial action, but we genuinely want to minimise any disruption to other NHS staff and, above all, to patients.
"Our dispute is with the government and our ballot for industrial action is a last resort in the face of their continued intransigence."
Thousands of medics protested in Leeds on October 28 against controversial changes they fear would lead to longer hours and reduced pay.
Health secretary Jeremy Hunt has claimed junior doctors would get an 11 per cent pay rise. But the measures would cut back on payments for working unsociable hours and actually cut pay, the BMA argued.
Mr Hunt was also accused by the BMA of trying to "gloss over the truth" by claiming no junior doctor would have their pay cut.


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NORD gratefully acknowledges Ernest C. Borden, MD, Taussig Cancer Institute. Cleveland Clinic Foundation, for assistance in the preparation of this report.
Gastrointestinal stromal tumors (GISTs) belong to a group of cancers known as soft tissue sarcomas. The number of new cases in the United States annually has been estimated to be 5,000-6,000. Tumors usually arise from the intestinal tract with the most common site being the stomach, followed by the small intestine, and then the colon/rectum with rare cases arising in the esophagus. There are also tumors that appear to arise in the membranous tissue lining the wall of the stomach (peritoneum) or in a fold of such membranous tissue (the omentum). There are also case reports of tumors arising in the appendix and/or pancreas. These tumors most commonly present with abdominal pain, bleeding or signs of intestinal obstruction. They spread most commonly to sites within the abdominal cavity and to the liver, although there are rare cases of spread to the lungs and bone. Some GISTs are noncancerous (benign) and do not spread (indolent); others are aggressive with extensive local invasion as well as distant metastases. Most cases result from a change (mutation) in one of two genes, KIT or PDGFR, which leads to continued growth and division of tumor cells. There are a few reported cases of families in which a gene mutation is inherited; however, the majority of tumors occur randomly for no apparent reason (sporadically) and not inherited (acquired mutation). Most cases arise in older adults.
Approximately 10-15% of cases of GIST in adults and 85% of cases in children are not associated with mutations in either the KIT or PDGFR genes. These cases are known as wild type GISTs and are sometimes grouped together under the umbrella term pediatric-like GIST. They may be associated with other genes or have no identifiable gene mutation.
GISTs were initially believed to be a single entity, but recent research has shown that there are several molecular subtypes with different characteristics including different prognoses, clinical symptoms, and different associated genes. that respond differently to various treatment options. Broadly, GISTs are classified as a soft tissue sarcoma. Sarcomas are malignant tumors that arise from the connective tissue, which connects, supports, and surrounds various structures and organs in the body. Soft tissue includes fat, muscle, nerves, tendons, and blood and lymph vessels.
The most common site of origin is in the stomach (39-70%), often presenting with pain, GI bleeding and/or a mass that can be seen or felt (palpable). GI bleeding can lead to anemia, which can lead to paleness, lightheadedness, and fatigue. Other symptoms may include a vague feeling of abdominal discomfort, a feeling of abdominal fullness or bloating, or feeling full sooner than normal after eating (early satiety). Other primary sites are the small intestine (31-45%), colon and rectum (10-16%), and mesentery (membranous folds that attach various organs to the body wall) or membranous lining of the abdomen (peritoneum) (8%). Patients presenting with tumors of the small intestine may also experience weight loss, fever, abscess, and/or urinary symptoms. There are rare cases presenting in the lowest third of the esophagus causing difficulty with swallowing and weight loss.
The primary site of the tumor may be a prognostic factor with small intestinal GISTs having a poorer survival than those originating in the stomach. In addition, intestinal location has been correlated with a high risk of spread (metastases). GISTs can also arise in the omentum and mesentery, not in association with a component of the gastrointestinal tract. Tumors present as large masses; some appear to develop in association with cysts.
Approximately 80-85% of GISTs are limited to one site upon diagnosis. GISTs spread most commonly to sites within the abdominal cavity and to the liver, although there are rare cases that have spread to the lungs and bone. GISTs rarely spread to the lymph nodes.
GISTs are extremely rare in children and adolescents. The symptoms and pathology of GISTs in these age groups is different from these tumors in most adults. Generally, pediatric GISTs present in the stomach, affect girls more often than boys, and usually are not associated with mutations in the KIT or PDGFR genes (wild type GIST). In addition, pediatric cases are more likely to show lymph node involvement and more likely to spread to the liver and abdomen. Usually, these tumors are more indolent than adult GISTs.
Initially, it was believed that age was a determining factor in the differences between cases of GIST in adults and children. However, some adult cases with wild type GIST share the distinct characteristic findings found in most pediatric cases. Thus, separating these cases based on age is unwarranted. Collectively, these cases are known as under the umbrella designation, pediatric-like GIST.
Also included in this umbrella category are cases associated with neoplastic syndromes such as Carney triad (gastric GISTs, paragangliomas, and pulmonary chondromas) and Carney-Stratakis syndrome (GISTs and familial paraganglioma).
There is no exposure or infection that is known to predispose to GISTs. It is known that the majority of tumors will have mutations in the KIT gene, and a minority, in the PDGFR gene. There are common sites for mutations. For the KIT gene, the most common mutation site is in exon 11, but can also involve exon 9, 13, and 17. Mutations in the PDGFR gene involve exon 12 or 18. Exon refers to the region of a gene that contains the code for producing the gene's protein. Each of these mutations is on the long arm of chromosome 4 (4q12).
Chromosomes, which are present in the nucleus of human cells, carry the genetic information for each individual. Human body cells normally have 46 chromosomes. Pairs of human chromosomes are numbered from 1 through 22 and the sex chromosomes are designated X and Y. Males have one X and one Y chromosome and females have two X chromosomes. Each chromosome has a short arm designated "p" and a long arm designated "q". Chromosomes are further sub-divided into many bands that are numbered. For example, "chromosome 4q12" refers to band 12 on the long arm of chromosome 4. The numbered bands specify the location of the thousands of genes that are present on each chromosome.
Current research suggests that abnormalities of DNA (deoxyribonucleic acid), which is the carrier of the body's genetic code, are the underlying basis for cellular malignant transformation. In individuals with cancer, malignancies most often develop due to abnormalities in the structure of genes within the nuclei of cells known as "oncogenes" or "tumor suppressor genes." Oncogenes control cell growth; tumor suppressor genes control cell division and ensure that cells die at the proper time. The KIT and PDGFR genes are oncogenes. Mutations of these genes lead to unrestricted growth of cancer cells. Most of these genetic mutations are acquired during life, are found only in cancer cells, and are not passed on to an affected individual's children. A few families with inherited mutations of the KIT gene have been described. They have early onset of GISTs in adolescence or young adulthood. Some families have altered skin pigmentation or difficult swallowing (dysphagia). At least one family has been described with an inherited mutation of the PDGFR gene. Inherited cases are extremely rare and are known as familial GIST.
Familial GIST is believed to be inherited as an autosomal dominant trait. Genetic diseases are determined by the combination of genes for a particular trait that are on the chromosomes received from the father and the mother. Dominant genetic disorders occur when only a single copy of an abnormal gene is necessary for the appearance of the disease. The abnormal gene can be inherited from either parent, or can be the result of a new mutation (gene change) in the affected individual. The risk of passing the abnormal gene from affected parent to offspring is 50% for each pregnancy regardless of the sex of the resulting child.
As stated above, wild type GISTs do not have mutations of the KIT or PDGFR genes. Some of these cases have been linked to genes involved in the succinate dehydrogenase (SDH) enzyme complex (i.e. SDHA, SDHB, SDHC or SDHD genes). These genes create (encode) enzymes involved in the formation of succinate dehydrogenase. Many pediatric patients are referred to as succinate dehydrogenase deficient because they have low levels of this enzyme.
Additional genes have been linked to wild type GISTs including BRAF, KRAS, and NRAS mutations. Many cases are also associated with overexpression of insulin-like growth factor 1, although the significance of this finding is not fully understood. Some cases have no identifiable gene mutation suggesting that additional genes can cause GISTs.
GISTs can also occur as part of a larger cancer predisposition syndrome such as Carney-Stratakis syndrome (CSS) and Carney's triad. CSS is a genetic disorder that is believed to be caused by mutations in the genes of the succinate dehydrogenase enzyme complex. It is inherited as an autosomal dominant trait. The exact, underlying cause of Carney triad is unknown. Individuals with neurofibromatosis type 1, a genetic disorder caused by mutations to the NF1 gene, are at a greater risk than the general population of developing a pediatric-like GIST, which usually presents as multiple tumors in the small intestine.
GISTs are believed to arise from specific cells known as interstitial cells of Cajal (ICC) or the undifferentiated precursor cells that ultimately develop into these cells. ICCs are the "pacemaker" cells of the gastrointestinal tract and are critical for proper GI motility. They help to generate and maintain electrical rhythmic activity within the GI tract including the series of muscular contractions that help propel food through the digestive system (peristalsis).
Researchers have also discovered that most GISTs are positive for CD117, a characteristic marker or antigen found on the surface of cancer cells. The discovery of CD117 can aid in the diagnosis of GISTs and can be an important factor in developing new treatments.
The typical patient with a GIST presents in the fifth to seventh decade of life, with some studies suggesting a male predominance. Children have also been found to present with GISTs. The disease in children may have a slower time course. Pediatric cases occur more often in females. There does not appear to be a link to a particular ethnic background. Individuals with familial GIST usually do not present with tumors until the mid-40s.
The exact incidence and prevalence of GISTs are unknown and estimates vary ranging from 9-19 people per 1 million in the general population. GISTs are the most common sarcoma of the gastrointestinal tract, but are estimated to account for only .1-3% of all gastrointestinal cancers.
Diagnosis can be by biopsy. Some tumors are diagnosed by endoscopy. The use of endoscopic ultrasound for lesions in the stomach can be helpful as these tumors can be below the surface of the stomach. If tumors are larger than 2-3 cm, a biopsy suggesting a benign lesion should be interpreted with caution.
Most patients undergo computed tomography (CT) scans to determine the extent of the tumor involved. It is most important to image the abdomen and pelvis as the most common sites of spread are within the abdominal cavity and the liver. If patients complain of bone pain, a bone scan should be considered, to determine if there is disease in the bones. PET scanning has been shown to be a helpful additional test; however, at this time it is not routinely covered by insurance companies.
Tumors that are confined to one site without evidence of spread (localized) are treated by surgical removal. There is no clear benefit for radiation therapy after surgery for this type of sarcoma. Surgery can cure most patients if the tumor is completely removed.
Standard chemotherapies are not effective for this type of sarcoma, with a less than 5% response rate. Imatinib mesylate (Gleevec®), a tyrosine kinase inhibitor that inhibits the KIT or PDGRF proteins responsible for tumor growth, has been found to be very effective in controlling disease that has spread. The majority of patients will have their tumors decrease in size or stabilize for many months. Although imatinib mesylate has been very effective at controlling disease, patients who have disease that has spread from the initial site (metastatic disease) rarely experience the complete disappearance of all disease. In addition, some individuals eventually develop resistance to imatinib mesylate. Surgery may be combined with imatinib mesylate to control metastatic disease.
Gleevec, which is manufactured by Novartis Pharmaceuticals Corporation, was granted accelerated approval by the Food and Drug Administration (FDA) for the treatment of advanced or metastatic GIST in 2002. Imatinib is an oral drug that inhibits the function of both KIT and PDGFR proteins. It has been shown to have significant activity in patients with recurrent tumors.
A subsequent accelerated approval was received in 2008 for adjuvant use by patients with GIST who have potentially curative resection (surgical removal) of GIST tumors, but who are at increased risk for a recurrence. This accelerated approval program provided earlier patient access to Gleevec while the confirmatory clinical trials were being conducted. In 2008, regular approval for the metastatic GIST indication was also granted.
Gleevec was granted regular approval by the FDA in 2012 as a treatment for use in adult patients following surgical removal of CD117-positive gastrointestinal stromal tumors. There is an increase in overall patient survival when the drug is taken for 36 months rather than the standard 12 months of treatment.
In 2006, another tyrosine kinase inhibitor, known as sunitinib malate (Sutent®), was approved by the FDA for the treatment of GIST in individuals in whom the disease had progressed despite therapy with Gleevec or who cannot take Gleevec. Sutent appears to be particularly effective in certain individuals with wild type GIST. Sutent is manufactured by Pfizer Inc.
In 2013, a third type of tyrosine kinase inhibitor known as regorafenib (Stivarga®) was approved by the FDA for the treatment of GIST, specifically for individuals with advanced GIST that cannot be treated surgically and who no longer respond to other FDA-approved treatments (i.e. Gleevec and Sutent). Regorafenib is a multi-kinase inhibitor that blocks the activity of several enzymes that promote cancer growth.
Alternative approaches include treatments directed at sites of liver involvement. Embolization or chemoembolization are ways of decreasing blood supply to the tumor sites within the liver and can control disease for some time. Another approach called radiofrequency ablation uses localized radiation; this overcomes the problem of side effects from treating the whole liver with radiation, as normally the liver is very sensitive to radiation.
Additional tyrosine kinase inhibitors are being studied for individuals with GIST including sorafenib, dasatinib, motesanib, nilotinib, masitinib, and crenolanib. These drugs differ in their ability to inhibit one or more tyrosine kinases. An inhibitor known dabrafenib that acts against the protein B-raf protein demonstrated prolonged antitumor activity in an individual with GIST associated with a mutation of the BRAF gene. More research is necessary to determine the long-term safety and effectiveness of these drugs and whether they have a role in the treatment of individuals with GIST.
GIST that are not associated with mutations in the KIT or PDGFR genes (i.e. wild type or pediatric-like GIST) do not respond effectively to treatment with tyrosine kinase inhibitors such as Gleevec or Sutent. Researchers are studying other treatment avenues to find effective treatments for these types of GIST.
Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.
For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:
Toll-free: (800) 411-1222
Email: [email protected]
For information about clinical trials sponsored by private sources, contact:
For more information about clinical trials conducted in Europe, contact: https://www.clinicaltrialsregister.eu/
Demetri GD, Reichardt P, Kang YK, et al. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomized, placebo-controlled, phase 3 trial. Lancet. 2013;381:295-302. http://www.ncbi.nlm.nih.gov/pubmed/23177515
Falchook GS, Trent JC, Heinrich MD, et al. BRAF mutant gastrointestinal stromal tumor: first report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance. Oncotarget. 2013;4:310-315. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712576/
Belinsky MG, Rink L, von Mehren M. Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors. Front Oncol. 2013;3:117. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656383/
Janeway KA, Pappo A. Treatment guidelines for gastrointestinal stromal tumors in children and young adults. J Pediatr Hematol Oncol. 2012;34:S69-S72. http://www.ncbi.nlm.nih.gov/pubmed/22525410
Koontz MZ, Visser BM, Kunz PL. Neoadjuvant imatinib for borderline resectable GIST. J Natl Compr Canc Netw. 2012;10:1477-1482. http://www.ncbi.nlm.nih.gov/pubmed/23221786
Roggin KK, Posner MC. Modern treatment of gastric gastrointestinal stromal tumors. World J Gastroenterol. 2012;18:6720-6728. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520160/
George S, Wang Q, Heinrich MC, et al. Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial. J Clin Oncol. 2012;30:2401-2407. http://www.ncbi.nlm.nih.gov/pubmed/22614970
Lamba G, Ambrale S, Lee B, et al. Recent advances and novel agents for gastrointestinal stromal tumor (GIST). J Hematol Oncol. 2012;5:21. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405472/
Blay J, Le Cesne A, Cassier PA, Ray-Coquard IL. Gastrointestinal stromal tumors (GIST): a rare entity, a tumor model for personalized therapy, and yet ten different molecular subtypes. Discov Med. 2012;13:357-367. http://www.ncbi.nlm.nih.gov/pubmed/22642917
Postow MA, Robson ME. Inherited gastrointestinal stromal tumor syndromes: mutations, clinical features, and therapeutic implications. Clin Sarcoma Res. 2012;2:16. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496697/#!po=46.8750
Beham AW, Schaefer IM, Schuler P, Cameron S, Ghadimi BM. Gastrointestinal stromal tumors. Int J Colorectal Dis. 2012;27:689-700. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359441/#!po=18.7500
Janeway KA, Kim SY, Lodish M, et al. Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. Proc Natl Acad Sci USA. 2011;108:314-318. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017134/
Kim SY, Janeway K, Pappo A. Pediatric and wildtype gastrointestinal stromal tumour (GIST): new therapeutic approaches. Curr Opin Oncol. 2010;22:347-350. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949288/
DeMatteo RP, Ballman KV, Antonescu CR, et al. Placebo-controlled randomized trial of adjuvant imatinib mesylate following the resection of localized, primary gastrointestinal stromal tumor (GIST). Lancet. 2009;373:1097-1104. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915459/
Li FP, Fletcher JA, Heinrich MC, et al. Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred. J Clin Oncol. 2005;23:2735-2743. http://www.ncbi.nlm.nih.gov/pubmed/15837988
Corless CL, Fletcher JA, Heinrich MC. Biology of gastrointestinal stromal tumors. J Clin Oncol. 2004;22:3813-25. http://www.ncbi.nlm.nih.gov/pubmed/15365079
Tosoni A, Nicolardi L, Brandes AA. Current clinical management of gastrointestinal stromal tumors. Expert Rev Anticancer Ther. 2004;4:595-605. http://www.ncbi.nlm.nih.gov/pubmed/15270663
Eisenberg BL, Judson I. Surgery and imatinib in the management of GIST: emerging approaches to adjuvant and neoadjuvant therapy. Ann Surg Oncol. 2004;11:465-75. http://www.ncbi.nlm.nih.gov/pubmed/15123459
Sattler M, Salgia R. Targeting c-Kit mutations: basic science to novel therapies. Leuk Res. 2004;28 Suppl 1:S11-20. http://www.ncbi.nlm.nih.gov/pubmed/15036937
McKusick VA, ed. Online Mendelian Inheritance in Man (OMIM). The Johns Hopkins University. Gastrointestinal Stromal Tumor; GIST. Entry Number; 606764: Last Edit Date; 12/20/2012. Available at: http://omim.org/entry/606764 Accessed March 5, 2014.
The information in NORD's Rare Disease Database is for educational purposes only and is not intended to replace the advice of a physician or other qualified medical professional.
The content of the website and databases of the National Organization for Rare Disorders (NORD) is copyrighted and may not be reproduced, copied, downloaded or disseminated, in any way, for any commercial or public purpose, without prior written authorization and approval from NORD. Individuals may print one hard copy of an individual disease for personal use, provided that content is unmodified and includes NORD's copyright.
National Organization for Rare Disorders (NORD)
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Burberry opened a shop in the Haymarket, London in 1891 which remains the site of Burberry's corporate headquarters today. The Burberry Equestrian Knight Logo was developed containing the Latin word Prorsum, which means forwards in English, and registered as a trademark in 1901. Thomas was commissioned by the War Office in 1914 to adapt their officer's coat to suit the conditions of warfare, which resulted in the design of the trench coat. The trench coat became popular with civilians after the war and the famous Burberry check was designed and used as a lining in Burberry's trench coats in the twenties.
Luxury Soft Brown Burberry Handbag
Burberry remained an independent company until 1955, when it was bought by Great Universal Stores. In 1967, over forty years since Burberry's classic Haymarket check was used as a coat lining, the Burberry check began to be widely used for umbrellas, scarves, luggage and Burberry purses.Unique Black Burberry Handbag
Burberry Handbag Gold Brown Combination
To appeal to the younger market the Novacheck was created and then altered to make the design bigger and then slanted in a diamond shaped pattern. Many of the latest Burberry purses sport the Novacheck pattern and it is widely used on two of the most popular designs in the Burberry purse line, the Bowling Bag and the classic Hobo. The Burberry bowling bag is available in large and small sizes and so is the Hobo.3 in 1 Colors Burberry Handbag
Not all designs of Burberry purses are designed with the Burberry fabric; the Baby Ruched Leather Lowry is a beautiful Burberry purse. This Burberry purse is fashioned of soft leather and has inverted pleat detailing on the front and back of the bag. It has black nickel finished hardware and a leather base with five feet. This classic Burberry purse has a leather and black nickel hanging tag, with the 'Burberry established 1856′ trademark inscribed on it. This particular Burberry purse has a jacquard lining woven with the prorsum knight motif along with two leather handles and detachable leather cross body strap.
Burberry Handbag Set


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Editor's Note: Sandy Speasl, a year-round resident of Hyatt Lake, Ore., and a member of Southern Oregon Citizens for Responsible Land Use Planning, wrote this opinion piece that appeared in the Medford, Ore., Mail Tribune. It pertains to a government official's decision that could force the closing of a park model resort in that southern Oregon community.
We wish to point out several inaccuracies in the Oct. 26 Mail Tribune article concerning Hyatt Lake Resort and to highlight some information about this decision and final order handed down by the independent hearings officer, Donald Rubenstein.
That decision was made after a three-month review of more than 1,000 pages of testimony and information compiled by all the parties in the appeal. Rubenstein's 42-page decision is available to the public at Jackson County Development Services, as is the county planning staff report.
Last May, neighbors were advised of a zoning decision concerning Hyatt Lake. Because we disagreed with the county's decision to permit development in a Forest Resource Zone, we filed an appeal. As citizens who live in the area, we were also alarmed when neighbors reported sewage flowing from Bob McNeely's property into the lake.
McNeely contends he is operating an RV resort. We contend he has built a planned unit development (subdivision) on land that is zoned Forest Resource and has been historically permitted as a seasonal campground only. Rubenstein agrees with our assessment.
We are extremely concerned about potential fire and propane explosions. Each cabin that McNeely has built has an attached 120-gallon propane tank, with no setbacks as required for a house. The cabins are as close together as 7 feet, and surrounded by extensive wooden decks and wooden skirting.
A fire expert who testified at the hearing noted, "This density exceeds the setbacks that are required even under a municipal code where the inhabitants have fire hydrants and city fire departments that respond in under five minutes. This resort has no means of suppression for a full structure fire, let alone multiple structures that would surely follow."
Rubenstein determined there was "no doubt that the risk of fire from the park model development significantly increases the risk of fire both within and beyond the resort."
In the article, McNeely claims he is entitled to develop 65 RV spaces and has septic licenses from Jackson County for 35 sites. The county found some evidence to support full service to 21 sites, but found no evidence of approved land-use permits or sanitary sewer permits since 1977.
"There were four or five cabins without kitchens that were rented in some winters but there was no overnight winter recreational use of the resort beyond that," Rubenstein's decision said.
In fact, many of the alterations for which McNeely sought permits had already been put in place, apparently violating his federal lease with the U.S. Bureau of Reclamation as well as county regulations. He also set up an office and administrative building at the resort without permits. It was red-tagged and ordered decommissioned. McNeely is apparently ignoring the county's order, as this office continues to be used daily.
In the article, McNeely states, "there is much misinformation, particularly about the cabins, which are clearly designated and designed as recreational vehicles." We would agree with him as to the misinformation.
According to the Oregon Structural Code, a "park trailer" is an RV "built on a single chassis, mounted on wheels … with a gross trailer area not exceeding 400 square feet when in the set-up mode." The hearings officer found that many of these "park models" set up at Hyatt Lake Resort are actually "two park models attached to one another to form structures that are wider than 30 feet and far in excess of the 400-square-foot limit that governs park model structures. Additionally, many of them have second stories and dormers and lofts, and all of the units have hot tubs. They are advertised as capable of sleeping between two and six people. Evidence establishes that units are used to sleep as many as eight."
McNeely clearly does not see these units as RVs either, as he openly advertises them as "cabins" and "destination homes." We encourage people to drive to Hyatt Lake to judge for themselves whether the units resemble RVs or permanent houses.
McNeely blames the county and his neighbors for his financial woes. We contend that Campers Cove LLC did not follow proper procedures.
Admittedly, the county made mistakes in allowing this development to occur in the first place. However, through public input and testimony — a right we may all exercise because we do not live in a communist country — the hearings officer determined what was necessary to correct these errors. It's now the public's job to support the county in seeing that the final decision and order are carried out if the state Land Use Board of Appeals determines it should be.


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For the fifth year in a row, Northeastern Junior College has seen an increase in enrollment for its January (J) Term. There are 269 unduplicated students on campus now who have been taking classes between Jan. 7 and 18, up 20.6 percent over last year's J-Term enrollment. The J-Term option offers students an accelerated format where they can earn up to three credits in two weeks. Students are in the classroom for 4 hours per day during this term. Many students use J-Term as a springboard to jump ahead on some college credit, or to pick up a class that they might not otherwise be able to fit into their schedules.
Northeastern has made it a point to offer degree level classes during this term and most of them are guaranteed transfer courses so that a student attending a university elsewhere may earn the credits here and have them transferred to the college or university where they attend full-time. The college offers a housing and meal package to students who opt to return early from Christmas break and enroll in a J-Term class.


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about jean
Jean Kwok, photo by Chris Macke
Jean Kwok is the award-winning, New York Times and international bestselling author of Searching for Sylvie Lee, Girl in Translation and Mambo in Chinatown. Her work has been published in twenty countries and taught in universities, colleges and high schools across the world. An instant New York Times bestseller, Searching for Sylvie Lee was selected for the Today Show Book Club and featured in The New York Times, Time, Newsweek, CNN, The New York Post, The Washington Post, O Magazine, People, Entertainment Weekly and more. Jean has been chosen for numerous honors including the American Library Association Alex Award, the Chinese American Librarians Association Best Book Award and the Sunday Times EFG Short Story Award international shortlist. She has appeared on The Today Show and spoken at many schools and venues including Harvard University, Columbia University and the Tucson Festival of Books. A television documentary was filmed about Jean and her work.
Jean immigrated from Hong Kong to Brooklyn when she was five and worked in a Chinatown clothing factory for much of her childhood while living in an unheated, roach-infested apartment. In between her undergraduate degree at Harvard and MFA in fiction at Columbia, she worked for three years as a professional ballroom dancer. Her beloved brother Kwan passed away in a tragic plane accident and was the inspiration behind Searching for Sylvie Lee. Jean is trilingual, fluent in Dutch, Chinese and English, and studied Latin for seven years. She lives in the Netherlands with her husband, two sons and four cats.
Jean's Story
Jean Kwok
The youngest of seven children and a girl at that, I was a dreamy, impractical child who ran wild through the sunlit streets of Hong Kong. No one was more astonished than my family when I turned out to be good at school. We moved to New York City when I was five and my only gift was taken from me since I did not understand a word of English.
We lost all our money in the move to the United States. My family started working in a sweatshop in Chinatown. My father took me there every day after school and we all emerged many hours later, soaked in sweat and covered in fabric dust. Our apartment swarmed with insects and rats. In the winter, we kept the oven door open day and night because there was no other heat in the apartment. That was the inspiration behind my debut novel, Girl in Translation.
Jean and her mother
As I slowly learned English my talent for school re-emerged. When I was about to graduate from elementary school, I was tested by a number of exclusive private schools and won scholarships to all of them. However, I'd also been accepted by Hunter College High School, a public high school for the intellectually gifted, and that was where I wanted to go.
By then, my family had stopped working at the sweatshop and we'd moved to a run-down brownstone in Brooklyn Heights that had been divided into formerly rent-controlled apartments. It was a vast improvement, but there was still no money to spare. If I didn't get into a top school with a full financial aid package, I wouldn't be able to go to college. Although I loved English, I didn't think it was a practical choice and devoted myself to science instead. In my last year in high school, I worked in three laboratories: the Genetic Engineering and Molecular Biology labs at Sloan-Kettering Cancer Research Center and the Biophysics/Interface Lab at the Veterans Administration Medical Center in Brooklyn.
I was accepted early to Harvard and I'd done enough college work to take Advanced Standing when I entered, thus skipping a year and starting as a sophomore in Physics. It was in college that I realized that I could follow my true calling, writing, and switched into English and American Literature. I put myself through Harvard, working up to four jobs at a time to do so: washing dishes in the dining hall, cleaning rooms, reading to the blind, teaching English, and acting as the director of a summer program for Chinese immigrant children. Like many working-class people, I didn't have the opportunity to take lessons for extracurricular activities as a child. It was in college that I also discovered I loved to dance.
Jean dancing with Jungie Zamora, photo by Montage Production
I graduated with honors, then while looking for a day job, stumbled across a newspaper ad that read: "Wanted: Professional Ballroom Dancer, Will Train." Terrified and unprepared, I went to the dance studio in an oversized red dress, black pumps I had covered with permanent marker to disguise their bald patches, and a long red scarf wrapped around my head like a turban. Somehow, despite all this, they invited me back for the audition, and then for the three-week training class. Ultimately, they hired me and taught me how to dance. I worked as a professional ballroom dancer for Fred Astaire East Side Studio in New York City for three years. I trained, did shows and competitions, and taught students how to waltz, swing, and mambo. For a young immigrant woman who had never fit in, who had never felt graceful, it was a great personal transformation. That was the basis for my second book, Mambo in Chinatown.
After winning Top Female Professional at Fred Astaire National Dance Championships, I left ballroom dance to pursue my true dream, writing. I went to Columbia to do my MFA in fiction. Before I graduated from Columbia, two stories of mine had been published in Story. In my last year at Columbia, I worked fulltime for a major investment bank as a member of a five-person computer team that addressed the multimedia needs of the Board of Directors.
I then moved to the Netherlands for love and went through the process of adjusting to another culture and learning another language again. I taught English at Leiden University and the Technical University of Delft in the Netherlands. I also worked as a Dutch-English translator until I finished Girl in Translation. After it was accepted for publication, I quit to write full-time.
Jean Kwok at CNN
Then my beloved older brother Kwan passed away in a tragic plane accident, which inspired my third novel, Searching for Sylvie Lee.
Jean's brother Kwan, Jean, and Jean's husband Erwin
Now, I live in the Netherlands with my husband and two sons, and sometimes, while walking alongside a canal, I am quite surprised by the path my life has taken. Surprised, and very grateful.
Content © Jean Kwok 2018 |
Website design: ilsabrink.com


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Rihanna Announces New Fragrance for Men + Shares Sexy Ads [PHOTOS]by Thomas Chau | PopCrush
Rihanna announced on Friday, Aug. 1, that she will be adding to her Rogue by Rihanna fragrance line with a new cologne for men. Rogue for Men will be hitting store shelves in September.
The 26-year-old pop star released Rogue for Women in Sept. 2013 under Parlux Fragrances. Rogue was the fourth fragrance under Rihanna following Reb'l Fleur, Rebelle and Nude.
RiRi made the announcement about Rogue for Men on Twitter and shared some of the sexy ads for the cologne.
"FINALLY!!! #ROGUE for MEN is here September!!! I've waited years for this moment!! :')" she writes in one tweet.
Her previous perfumes were made available on her official site, as well as retailers such as Macy's and Dillards. It is expected that Rogue for Men will follow a similar distribution plan.
In the meantime, the Barbados-born singer will be hitting the road in August with Eminem as part of The Monster Tour.
Check out Rihanna's ads for Rogue Man below.
#ROGUEMAN is COMING this September!!!! pic.twitter.com/dk11plqmac
— Rihanna (@rihanna) August 1, 2014
FINALLY!!! #ROGUE for MEN is here September!!! I've waited years for this moment!! :') pic.twitter.com/tjBLKD7tXU
— Rihanna (@rihanna) August 1, 2014
LADIES!!! This September wake up next to your man smelling like this!!! Makes you wanna steal his Tshirts #ROGUEMAN pic.twitter.com/HLqeeXb0bx
— Rihanna (@rihanna) August 1, 2014
See Rihanna + Other Celebrity Wardrobe Mishaps


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Numbers out today from the state Employment Development Department, or EDD, show the jobless rate in April was 7.1 percent, down from 8.1 percent in March. George Marley with the EDD says all of the employment sectors they track either gained jobs or staid flat...but none lost jobs.
"That was probably the most interesting fact when I was looking at the numbers," says Marley. "Normally we see at least one or two industries down from the month over. In this particular month we saw nine industries up and only three - government, natural resources/mining and information - remaining steady from last month. So definitely some good numbers here that came out this month."
Job sectors with the biggest gains include: professional and business services; administrative and support; and healthcare and social assistance.


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Firozpur is the is a District of Punjab state, India. Punjab is a state in the northwest of the Republic of India. The state capital is located in Chandigarh, which are a Union Territory and also the capital of the neighbouring state of Haryana. Punjab is one of the most fertile regions on earth.
alljobs4u.com is trying to publish all kinds job opening in Firozpur. Here you will get all kind of upcoming Job Vacancies in Firozpur like Top Categories IT Software jobs, BPO jobs, Sales jobs, Finance jobs, Marketing jobs, Fresher jobs, Walk-in interviews, Engineering jobs, HR Administration jobs and Telecom jobs. If you are Graduate or under graduate and looking for job in Firozpur then this page is valuable for you.
Are you looking a career in Government jobs ? We are published all kinds of government jobs related notification. Which includes Railway , Bank , Defence , Healthcare , Teaching , Research , Power and Energy etc.
If You Are Looking To Relocate To Delhi, Bangalore, Mumbai, Pune, Chennai, Hyderabad Or Any City Of India, We Provides Latest Private Sector Jobs In India. Which include freshes or Experience jobs like IT, BPO, etc.
If You Are Looking To Relocate To Delhi , Bangalore , Mumbai , Pune , Chennai , Hyderabad Or Any City Of India , We Provides Latest Private Sector Jobs In India . Which include freshes walking interview jobs like IT , BPO , etc .
Jobseeker can subscribe daily job alerts . Jobseeker will get everyday job alerts on register email id's. Recruiters also can post jobs of our job portal affordable cost. So Register today to get more job alerts.


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APPLY HERE: https://discord.gg/ZYmpMkt
Skyblivion Master for development: https://tesrenewal.com/files/skyblivion.esm
Skyrim Stripped Master: https://tesrenewal.com/forums/general-development/working-wi...
Pre-stripped Master: https://drive.google.com/file/d/0ByQVbq7PZPW5aFJmUFpNRlpqMFE
This topic exists out of 2 parts:
Available and Taken jobs,
If something is already taken it means that some AWESOME individual is already working on this... but if you think that you can be of help you can simply message them and see if you can collaborate and make something even better together.
Available [Development]
Claim jobs while you still can! Its important that you mention below what you are doing so that you wont start working on something thats already being done or completed. I will add your names to the spreadsheet on whatever you are working on.
Navmeshing: COMPLETED!
We need people for this job who know what they're doing (professionals if you will)
We need navmeshing. With a working collisions it will be possible. Without navmeshes we can't go on with AI packages and quests. I'm talking about hand made high quality navmeshes, not autogenerated ones. Skyblivion is 2x times bigger than Skyrim, and 4x than Skywind, and we have a risk of bloating master file to the point of overloading CK. Navmeshes must be highly optimized using absolutely minimum number of islands and triangles to be small in size. -Zilav
Interactive Oblivion Map: http://www.uesp.net/maps/obmap/obmap.shtml
Available area's and claims can be found on the spreadsheet:
Very useful navmesh guide(thanks Rovan): http://geck.bethsoft.com/index.php?title=Navmesh_Creation_Wo...
Navmesh topic:
Where to start with this one... We will need convert all models from Oblivion and we will ave make sure that they work.
Feel free to work on any of the models down below but make sure that others arent already working on it. if someone IS already working on it try to work something out and see if you can work together. If you think you can help please join our discord chat here: https://discord.gg/ZYmpMkt and apply.
IMPORTANT: In order to use the new models you need to keep the same size and pivot so models can be replaced without changing position/rotation/scale in master file. The best thing to compare it to would be the SMIM mod for Skyrim: http://www.nexusmods.com/skyrim/mods/8655/? this way we wont have to put allot of time and effort in re-scaling and positioning the new models
We are looking for people to help us remodel all of Oblivions iconic weapons
Use the links below to see pictures of the original weapons to model the new one's after, plus all information about the weapons (damage, weight, weapon type etc)
Full list of weapons: http://elderscrolls.wikia.com/wiki/Weapons_(Oblivion)
Specific weapons :
Deadric weapons: ? http://elderscrolls.wikia.com/wiki/Daedric_Weapons_(Oblivion)
Dremora weapons: http://elderscrolls.wikia.com/wiki/Dremora_Weapons_(Oblivion)
Dwarven weapons: http://elderscrolls.wikia.com/wiki/Dwarven_Weapons_(Oblivion)
Ebony weapons:? http://elderscrolls.wikia.com/wiki/Ebony_Weapons_(Oblivion)
Elven weapons: http://elderscrolls.wikia.com/wiki/Elven_Weapons_(Oblivion)
Glass weapons: http://elderscrolls.wikia.com/wiki/Glass_Weapons_(Oblivion)
Iron weapons: http://elderscrolls.wikia.com/wiki/Iron_Weapons_(Oblivion)
Silver weapons: http://elderscrolls.wikia.com/wiki/Silver_Weapons_(Oblivion)
Steel weapons: http://elderscrolls.wikia.com/wiki/Steel_Weapons_(Oblivion)
Shivering Isles weapons: http://elderscrolls.wikia.com/wiki/Category:Shivering_Isles:...
We need people to convert the armor's from oblivion so that we can use those as placeholders and replace them with out own custom made counterparts. If its not converted yet you can volunteer to do so. (converting is completed)
If its already converted you can start working on making your own models, dont forget to check the spreadsheet to look if its not already being done by someone.
HEAVY ARMOR'S http://elderscrolls.wikia.com/wiki/Armor_Sets_(Oblivion)
LIGHT ARMOR'S http://elderscrolls.wikia.com/wiki/Armor_Sets_(Oblivion)
Clothes have been converted from the game but we are aiming to replace most if not all of them with custom made models.
Spreadhseet to track the progress: https://docs.google.com/spreadsheets/d/1Kpb_DGRvmrlLuS2SgL8Q...
We are looking to remake as many assets as we can, this includes environmental, architecture, consumable items and everything in between. If you think you can help please join our discord chat here: https://discord.gg/ZYmpMkt and apply.
Creatures and monsters:
Creatures are what makes a game interesting to play and the same goes with oblivion. some of the vanilla Skyrim creatures and monsters can be used to replace the oblivion one's but allot of creatures have to be created from the ground up. We are looking for talented 3D artists preferably with an understanding of rigging to help us here. If you think you can help please join our discord chat here: https://discord.gg/ZYmpMkt and apply.
List of creatures and monsters: http://goo.gl/iVrtc
(with images, just scroll down)
We need scripters to help us with mechanics such as spellcrafting and allot of other jobs that have to be done using scripts. If you think you can help please join our discord chat here: https://discord.gg/ZYmpMkt and apply.
FaceGen NPC's [COMPLETED]:
As we know all NPC's have a unique look and the aim obviously is to have every NPC in Skyblivion. Certain NPC's have unique features and at this point all NPC's look alike.. We have to manually try to recreate the faces as good as possible.
List of NPC's: http://www.uesp.net/wiki/Category:Oblivion-NPCs
(images included)
Quests[not needed until further notice]:
All great TES games have a ton of quests and the same thing goes for Oblivion. Soooo you've probably figured out that we need those quests to work in Skyblivion... so here is a list of all quests that need to be converted. Main quest has the highest priority.
List of quests: http://goo.gl/gj4oZ
Feel free to download :)
For additional questions PM me.