text:
Protesters descended on Chicago once again Thursday, the day after hundreds of demonstrators gathered in a citywide walkout that shut down several major streets in the city's downtown, calling for Mayor Rahm Emanuel's resignation.
The first event happened around 8 a.m., when dozens of medical students from several organizations staged a "die-in" in front of City Hall. The group said it was protesting a "public health crisis of excessive police violence and complete lack of accountability by city leaders in the killing of Laquan McDonald."
Protesters held signs that read "White coats for black lives" and "Rahm is not healthy for Chicago."
The "die-in" lasted 16 minutes, one minute for each time 17-year-old McDonald was shot by a Chicago police officer last year.
The release last month of dashcam video showing the 2014 killing of McDonald has set off weeks of largely peaceful protests and led to the dismissal of the city's police chief.
At 2 p.m., a press conference was held outside Chicago Police Headquarters where community leaders lashed out at Mayor Rahm Emanuel.
Chicago police crime survivors also gathered around 3:30 p.m. outside the Dirksen Federal Buildingto demand the DOJ "prosecute all criminal cops."
The victims and their families were expected to meet with a representative for U.S. Attorney Zachary Fardon at 4 p.m., according to a release from the Chicago Alliance Against Racist & Political Repression. The group has also planned a 5 p.m. rally after the meeting.
On Wednesday, Emanuel publicly apologized for the shooting death of McDonald and vowed to fix broken Chicago police practices, though many protesters argued one speech can't fix decades of police corruption.
April, 2016
4/13/16 'Day of Reckoning': Task Force Releases Scathing Report on CPD
4/13/16 City Council Authorizes $6.5M in Police Misconduct Settlements
4/13/16 Emanuel Wants Hate Crime Probe for Racist Scanner Comments
4/13/16 Panel Warns Chicago Police Must Acknowledge Racism
4/8/16 Report: Chicago's Ill-Fated Top Cop Search Cost $500,000
4/4/16 Chicago May Pay $4.9M to Family of Man Who Died in Custody
4/4/16 Emanuel Requests Hate Crime Investigation
4/1/16 Emanuel Makes List of "Most Disappointing Leaders"
March, 2016
3/31/16 Jason Van Dyke Gets New Job With Fraternal Order of Police
3/31/16 Officer Jason Van Dyke Hired by Police Union
3/28/16 Mayor Announces Johnson as Interim Police Superintendent
3/28/16 Emanuel Chooses Top Cop, Rejects 3 Finalists: Sources
3/24/16 Chicago Black Caucus Wants Meetings With Top Cop Candidates
3/24/16 IPRA to Re-Examine All Closed Police-Involved Shootings
3/23/16 Officer Jason Van Dyke Asks Not to Appear at Hearings
3/18/16 Emanuel Offers No Timeline for Police Superintendent Replacement
3/17/16 3 Finalists Announced in Chicago Top Cop Search
3/17/16 Finalists for Chicago's Next Top Cop Revealed
3/16/16 CPD Union Seeks to Postpone IG's McDonald Probe
3/16/16 Foxx on Win: 'This Work Is Deeply Personal to Me'
3/16/16 Embattled Anita Alvarez Loses to Kim Foxx
3/14/16 Chicago Police Investigate After Racial Slur Heard on Radio
3/14/16 How the Laquan McDonald Case Shaped the Illinois Primary
3/10/16 'Become a One-Issue Campaign': Alvarez Speaks on Criticisms
3/1/16 As Violence Escalates, Police Search for Answers
February, 2016
2/25/16 Meet Chicago's New FBI Chief
2/17/16 Chicago Vows to Release Police Shooting Videos Faster
2/16/16 Special Prosecutor Sought in Laquan McDonald Shooting Case
2/16/16 Emanuel Bumped From Top Spot of Most Powerful Chicagoans
2/12/16 Inverted Batteries to Blame for Lack of Laquan McDonald Audio: Docs
2/12/16 Docs Solve Mystery of Missing Audio in McDonald Video
2/11/16 Police Documents Show Why No Audio In McDonald Shooting
2/10/16 Ward Room Campaign Round-Up: Democratic U.S. Senate Candidates Square Off
2/10/16 City Expected to Settle Police Hiring Lawsuit
2/8/16 Alvarez Battles Opponents During Editorial Board Endorsement Sessions
2/8/16 Aldermen Halt Emanuel's Plan to Raise Smoking Age
2/8/16 Garry McCarthy Being Considered for Top Cop Job in London: Report
2/5/16 Mom of Teen Fatally Shot by Police Calls for Federal Probe
2/4/16 Aldermen Look to Improve City's Mental Health Services
2/4/16 Report: CTU Garners Triple the Support of Emanuel
2/4/16 Jesus 'Chuy' Garcia Endorses Kim Foxx for State's Attorney
2/4/16 Ward Room Campaign Round-Up: Week 2
2/2/16 Alvarez Holds Lead in Latest State's Attorney Poll
2/1/16 Foxx Blasts Alvarez's Handling of McDonald Shooting in Campaign Ad
2/1/16 Many Iowa Republicans Undecided Before Caucuses
2/1/16 Rahm Emanuel's Approval Rating Hits Record Low: Report
January, 2016
1/26/16 Emanuel Mandates Police to Receive Training on Mental Illness
1/26/16 Van Dyke's Attorney Says He Plans to Seek a Change of Venue
1/26/16Zopp Calls for Reforms to Law Enforcement, Criminal Justice System
1/26/16 Alvarez Challenged by Opponents During State's Attorney Debate
1/29/16 Police Developing New Strategy to Combat Crime, Emanuel Says
1/26/16 DC Police Chief Not Interested in Top Job With Chicago PD
1/25/16 Retired Philadelphia Police Chief Returns to Advise CPD
1/22/16 2 Officers in Laquan McDonald Case Put on Administrative Leave
1/21/16 Judge OKs Court Cameras for Jason Van Dyke Trial
1/19/16Aldermen Propose Equipping Every Chicago Officer With a Taser
1/17/16Bill Could Make it Harder for Police to Prevent Release of Videos
1/17/16 Hillary Clinton Walks Back Support for Emanuel
1/17/16Anita Alvarez Defends Herself at State's Attorney Forum
1/15/16Cops Called to Testify Before Grand Jury in McDonald Case
1/14/16Cook County Dems Endorse Foxx for State's Attorney
1/13/16Lawyer Blasts IPRA as Less Than Independent
1/13/16Chicago Withdraws Objection to Release of Shooting Video
1/13/16 Chicago Police Street Stops May Have Decreased Due to New Form Procedure
1/12/16Police Board Holds Meeting on Search for New Top Cop
1/12/16Boycott of Mayor's MLK Invitation Grows
1/12/16More City Leaders Boycott Mayor's MLK Breakfast
1/11/16 Judge to Decide This Week on 2013 Shooting Video's Release
1/10/16WH Chief of Staff: Obama 'Confident' in Emanuel
1/10/16 Chicago Hires Former U.S. Attorney to Review Law Dept.
1/9/16FBI Investigating 2013 Fatal CPD Shooting
1/8/16 McDonald Family Accused City of Intimidating Witnesses: Docs
1/8/16Cook County Dems Reopen Slating Process for State's Attorney Race
1/7/16Emanuel Says Law Department Will Be Reviewed
1/7/1622 CPD Officers Disciplined for Improper Use of Dashcams
1/6/16 Ex-Chicago Attorney's Cases Examined After Judge's Ruling
1/5/16 Emanuel Says Federal Probe of City's Law Dept. Not Needed
1/5/16Reparations Paid in Chicago Police Torture Case
1/5/16 Top City Lawyer Steps Down After Judge Rules He Hid Evidence
1/4/16 Sharon Fairley Restructures IPRA Leadership Team
1/3/16Ill. Considers Allowing Recall Attempts of Chicago Mayor
December, 2015
12/31/15City Releases Emails on Laquan McDonald Shooting
12/31/15Activists March to Remember Victims of Gun Violence in 2015
12/30/15 Emanuel Meets With Family of Mother Killed in Police-Involved Shooting
12/30/15Emanuel on New Taser Policy: 'Force Can Be the Last Option'
12/30/15Emanuel to Announce Chicago Police Plan Wednesday
12/29/15Officer Jason Van Dyke Enters Not Guilty Plea
12/24/15 Audio Reveals Taser Requested in McDonald Shooting
12/24/15 Demonstrators March on Michigan Ave. Over McDonald Shooting
12/23/15 Audio Reveals Taser Requested in McDonald Shooting
12/23/15 Emanuel Lands on List of 'The Worst People of 2015'
12/18/15 Angry Group Confronts Officer Jason Van Dyke Outside Court
12/18/15 Officer Jason Van Dyke Makes First Court Appearance Since Indictment
12/18/15 Behind The Story: Carol Marin on Covering Laquan McDonald
12/18/15 Protesters Flood State Street, Call for Justice
12/18/15 Sen. Mark Kirk Reacts to Laquan Mcdonald Shooting
12/18/15 Emanuel Flip Flops on DOJ Investigation, Now Supports It
12/17/15 Rev. Jackson to Lead Laquan McDonald Rally on State Street
12/17/15 Video From Burger King Near McDonald Shooting Released
12/17/15 Who Was Laquan McDonald?
12/17/15 Officials Release Full Laquan McDonald Police Report
12/17/15 Bernie Sanders Calls for Federal Probe of CPD
12/17/15 Madigan Calls for Investigation of Chicago Police Department
12/17/15 Retired Officers Say CPD Misconduct 'Going On for Years'
12/17/15 Mayor: City Will Support Release of Another Dashcam Video
12/17/15 Anita Alvarez Says 'No Way' She Will Consider Resigning
12/17/15 Rauner Says He Cried When He Saw McDonald Video
12/17/15 Questions Remain After Firing of Police Supt. McCarthy
12/17/15 Mayor Announces Task Force on Police Accountability
12/17/15 White House Expresses Support for Mayor Emanuel
12/17/15 Alvarez on Firing of McCarthy: 'It's the Mayor's Prerogative'
12/17/15 Dashcam Video Sought of Another Fatal Police Shooting
12/17/15 Foxx Earns Endorsements Over Embattled Alvarez
12/17/15 Email Reveals First Question to City About Laquan McDonald Video
12/17/15 McCarthy's Tenure Full of Highs and Lows
12/17/15 Politicians, Activists Praise Firing of McCarthy
12/17/15 John Escalante Named Interim Chicago Police Superintendent
12/17/15 Officer Charged in Laquan McDonald's Death Posts Bond
12/17/15 Rep. Gutierrez Withdraws Support for Alvarez's Re-Election
12/17/15 McCarthy: Initial Release on McDonald Shooting 'Mistaken'
12/17/15 McCarthy Fired Week After McDonald Shooting Video Released
12/17/15 NAACP: 10 Arrested at Protest Outside City Hall
12/17/15 Photos Show Officer at Burger King Night of McDonald's Death
12/17/15 Mayor Goes Silent After Release of Laquan McDonald Video
12/17/15 Anita Alvarez Responds to Calls for Her Resignation
12/17/15 Demands to Fire McCarthy Grow in Wake of Protests
12/17/15 Threat That Canceled Classes at UofC Cited McDonald Shooting
12/17/15 Fraternal Order of Police Raises Bond Money for Van Dyke
12/17/15 NAACP Members Protest Laquan McDonald Shooting
12/17/15 Dwyane Wade Pays Tribute to Laquan McDonald on Shoes
12/17/15 Chicago to Expand Police Body Camera Program
12/17/15 4 Arrested in Magnificent Mile Protests
12/17/15 Mag Mile Reopens After Protesters Block Traffic, Stores
12/17/15 Protesters March at City Hall for Laquan McDonald, Tyshawn Lee
12/17/15 Obama 'Deeply Disturbed' by Video of McDonald's Shooting
12/17/15 What Chicago Police Said The Night Laquan McDonald Died
12/17/15 Protesters Shut Down Mag Mile After Dash-Cam Video Release
12/17/15 Politicians Call For Reform In Wake of Laquan McDonald Shooting
12/17/15 Arrests Made After Protesters Damage City Christmas Tree
12/17/15 4 New Dash-Cam Videos Released of Laquan McDonald Shooting
12/17/15 Alvarez Gives Minute-by-Minute Report of Teen's Fatal Shooting
12/17/15 Missing Minutes From Security Video Raises Questions
12/17/15 Timeline: What Pros. Say Happened Night McDonald Was Shot
12/17/15 Investigator Analyzes Dash-Cam Video of Chicago Teen's Shooting
12/17/15 Images Capture Tense Moment Between Protesters, Police
12/17/15 Calls for Mayor's Resignation Flood Social Media
12/17/15 Questions Remain About Missing Audio in McDonald Dash-Cam Video
12/17/15 Chicago NAACP Chapters Call for Investigation Into IPRA
12/17/15 Records Show Officer in McDonald Case Had Previous Complaints
12/17/15 Charges Dropped Against Influential Activist After Arrest
12/17/15 Dash-Cam Video Shows Laquan McDonald's Fatal Shooting
12/17/15 Alvarez Addresses Missing Minutes From Security Video
12/17/15 5 Arrested During Overnight Protests for Laquan McDonald
12/17/15 Clinton, Sanders Speak Out About Laquan McDonald Video
12/17/15 Hundreds Protest After Release of Laquan McDonald Video
12/17/15 CPS Offers Counseling After Dash-Cam Video Release
12/17/15 Protesters March After Release of Laquan McDonald Video
12/17/15 Officer to Be Indicted in Laquan McDonald Case: Source
12/17/15 CPD Failed to Properly Probe Death of Teen Shot by Cop: Suit
12/17/15 6 Chicago Officers Named in Settlement Agreement
12/17/15 GoFundMe Removes Page to Help Cop Charged With Murder
12/17/15 McDonald Family Asks for 'Calm' Upon Video Release
12/17/15 City Leaders Fear for Release of Video of Teen's Shooting Death
12/17/15 Leaders Call for Peace Ahead of Potential Unrest
12/17/15 Jesse Jackson Speaks Out on Laquan McDonald
12/17/15 Grand Jury Indicts Officer in Laquan McDonald's Death
12/17/15 Audio Missing on Video of Teen Shot by Cop: Attys
12/17/15 Judge Orders Release of Video Showing Teen's Shooting Death
12/17/15 Ben Carson Calls McDonald Shooting 'Abominable'
12/16/15 Board Calls on Alvarez to Appear Before Criminal Justice Committee
12/16/15 Department of Justice Begins Probe Into CPD
12/16/15 Urban Prep Academy Students Yell "16 Shots" During Mayor's Visit
12/16/15 Cop in Laquan McDonald Case Tied to Another Police Shooting
12/16/15 Chicago Protest Against Cop-Involved Shooting Blocks Traffic
12/15/15 Cops Want Emanuel to Testify About Police 'Code of Silence'
12/15/15 After Deadlock, Baltimore Jurors Continue in Officer Trial
12/15/15 City Hall Emails Show Trail to Top Emanuel Aides
12/15/15Protesters Accused of Trying to Climb Rockefeller Center Tree
12/13/15 The Rise of the New Chicago Protesters
12/13/15 Chance the Rapper References McDonald Shooting on 'SNL'
12/12/15 Mayor Emanuel is Back in Hiding
12/11/15 Activists Call for DOJ to Expand Investigation in Chicago
12/11/15 'Change Is Needed': McDonald Family Speaks Out
12/11/15Pastors Seek Special Prosecutor in McDonald Case
12/10/15Expert: Process of Recalling Rahm 'Not a Quick Possibility'
12/10/15Protesters Continue to Call for Mayor's Resignation
12/10/15Sheriff's Officers Were at Scene of Laquan McDonald Shooting
12/10/15 Expert Says Recalling Mayor Emanuel Would Not Be an Easy Process
12/10/15 Police Board Begins Search for New Chicago Police Superintendent
12/10/15Mayor's Office Responds to Recall Legislation
12/10/15 Illinois Lawmaker Files Legislation to Remove Mayor Emanuel
12/9/15Protesters Block Traffic in March Through Downtown Chicago
12/9/15 Some in City Hall Knew of McDonald Video 2 Months After Shooting: Emails
12/9/15 'Happened on My Watch': Mayor Vows to Fix Police Corruption
12/9/15 Poll: Half of Chicago Voters Think Emanuel Should Resign
12/9/15Chicago Cop Charged With Murder in Teen's Fatal Shooting
12/8/15 IPRA Asks Inspector General to Investigate McDonald Case
12/7/15 Feds Launch Civil Rights Investigation into CPD Practices
12/7/15 Dashcam Video Showing 2nd Police Shooting Released
12/7/15 CPD's Chief of Detectives Retires Suddenly
12/7/15 Head of Independent Police Review Authority Resigns
12/7/15 Justice Department to Investigate CPD
12/6/15 Police Accounts Appear to Differ With McDonald Shooting Video
12/5/15 Officials Release Full Laquan McDonald Police Report
12/4/15 Video From Burger King Near McDonald Shooting Released
12/4/15 Chicago's Interim Cop Talks Potential Federal Probe
12/4/15 Bernie Sanders Calls for Federal Probe of CPD
12/4/15 Rev. Jackson to Lead Laquan McDonald Rally on State Street
12/3/15 Emanuel Flip Flops on DOJ Investigation, Now Supports It
12/3/15 Family Fights to Have Video of Another Teen's Fatal Shooting Released
12/3/15 Mayor: City Will Support Release of Another Dashcam Video
12/3/15 Rauner Says He Cried When He Saw McDonald Video
12/3/15 Anita Alvarez Says 'No Way' She Will Consider Resigning
12/3/15 Retired Officers Say CPD Misconduct 'Going on For Years'
12/2/15 Madigan Calls for Investigation of CPD
12/2/15 Clinton Calls for Federal Probe of Chicago Police Tactics
12/1/15 Mayor Announces Task Force on Police Accountability
12/1/15 McCarthy: Initial Release on McDonald Shooting 'Mistaken'
November, 2015
11/30/15 Photos Show Officer at Burger King Night of McDonald's Death
11/30/15 Officer Charged in Laquan McDonald's Death Posts Bond
11/30/15 Threat That Canceled Classes at UofC Cited McDonald Shooting
11/30/15 Mayor Goes Silent After Release of Laquan McDonald Video
11/30/15 Anita Alvarez Responds to Calls for Her Resignation
11/30/15 Demands to Fire McCarthy Grow in Wake of Protests
11/29/15 Dwyane Wade Pays Tribute to Laquan McDonald on Shoes
11/29/15 Fraternal Order of Police Raises Bond Money for Van Dyke
11/28/15 Protesters March at City Hall for Laquan McDonald, Tyshawn Lee
11/28/15 4 Arrested in Mag Mile Protests
11/27/15 What Chicago Police Said the Night Laquan McDonald Died
11/27/15 Protesters Shut Down Mag Mile After Dash-Cam Video Release
11/26/15 Laquan McDonald Was Trying to Start Over: School
11/26/15 4 New Dash-Cam Videos Released of Laquan McDonald Shooting
11/26/15 Arrests Made After Protesters Damage City Christmas Tree
11/26/15 Obama 'Deeply Disturbed' by Video of McDonald's Shooting
11/25/15 Clinton, Sanders Speak Out After Release of Laquan McDonald Video
11/25/15 Chicago NAACP Chapters Call for Investigation Into IPRA
11/25/15 Protesters Plan March on Michigan Avenue on Black Friday
11/15/15 Calls for Mayor's Resignation Flood Social Media After Dash-Cam Video Release
11/25/15 Chicago Braces for Protests Following Dash-Cam Video Release
11/25/15 Charges Dropped Against Influential Activist After Arrest
11/25/15 Timeline: What Prosecutors Say Happened the Night Laquan McDonald Was Shot
11/25/15 Chicago's Black Caucus Calls for McCarthy's Release
11/25/15 5 Arrested During Overnight Protests for Laquan McDonald
11/24/15 Records Show Officer in McDonald Case Had Previous Complaints
11/24/15 CPS Offers Counseling After Released of McDonald Video
11/24/15 Protesters March After Release of Laquan McDonald Video
11/24/15 WARNING: Dash-Cam Video Showing Teen's Fatal Shooting Released
11/24/15 Alvarez Addresses Missing Minutes From Security Video
11/24/15 Alvarez Gives Minute-by-Minute Report of Teen's Fatal Shooting
11/24/15 Family of Laquan McDonald Asks for 'Calm' Upon Release of Dash-Cam Video
11/24/15 Alvarez Defends Timing of Charges in Laquan McDonald Case
11/24/15 GoFundMe Removes Page Seeking Donations for Chicago Cop Charged With Murder
11/24/15 Chicago Cop Charged With Murder in Teen's Fatal Shooting
11/23/15 Community Leaders Call for Peace Ahead of Potential Unrest
11/23/15 Who Was Laquan McDonald?
11/23/15 Officer to Be Indicted in Laquan McDonald Case: Source
11/21/15 Jesse Jackson Speaks Out on Laquan McDonald
11/20/15 Attorney: Cop Accused in Teen's Fatal Shooting 'Scared to Death'
11/19/15 Judge Orders Release of Video Showing Teen's Shooting Death
11/18/15 Ill. Attorney General Asks Chicago to Release Shooting Video
11/14/15 Emanuel: Hold Release of Video of Shooting
11/13/15 Chicago Police Dashboard Cameras Questioned in Death of Teen Shot by Cop
October, 2015
10/28/15 Judge to Rule on Video Showing Officer Fatally Shooting Teen
July, 2015
7/16/15 Audio Missing on Video of Teen Shot by Cops: Attys
7/9/15 City Emails Refer to Complications in Police Version of How Teen Was Shot
7/2/15 Six Chicago Officer Named in Settlement Agreement
May, 2015
5/27/15 Missing Minutes From Security Video Raises Question
5/12/15 CPD Failed to Properly Probe Death of Teen Shot by Cop: Suit
4/15/15 Chicago Council Approves $5M Settlement in Police Shooting
4/14/15 Feds Probe Death of Teen Shot 16 Times by Cop
October, 2014
10/21/14 Teen Shot, Killed by Police Officer on Chicago's Southwest Side


text:
Mayor's Office
The City Recycling Office encourages football fans to participate in the 2010 Game Day Challenge by recycling cans and bottles at the October 30th UNL football game against Missouri.
The program, sponsored by the U.S. Environmental Protection Agency (EPA), is a nationwide competition to see which school can generate the least waste per person.
Other Big 12 Conference schools competing to see who can reduce, reuse, and recycle the most waste during an October football game include Baylor University, Iowa State University, Kansas State University, University of Missouri, and University of Texas.
"The EPA chose college football as the venue for this program because games generate a lot of waste in a short amount of time," said City Recycling Coordinator Gene Hanlon. "Every home game, at least 6,000 lbs of plastic goes to the landfill. We can stop that from happening and prove again that the Huskers have the best fans in the nation."
Volunteers are needed to help with the effort.
For more information on the Game Day Challenge, contact Prabhakar Shrestha at 472-9139 (firstname.lastname@example.com) or Linda Stevenson at 441-8004 (email@example.com).
For more information on recycling, visit lincoln.ne.gov (keyword: recycle).

subset: commoncrawl


text:
LiveWell Longmont has been around since 2008. I didn't know much about it until last month, when I attended a breakfast it hosted during which it tried to introduce itself to the business community at large.
The question I couldn't get out of my head was, "What took it so long?"
LiveWell Longmont is a spinoff of LiveWell Colorado, a nonprofit dedicated to reducing obesity in the state by promoting healthy eating and a more active lifestyle. On the local level, it's a partnership primarily of the city, the St. Vrain Valley School District and Longmont United Hospital.
LUH and city employees, the school district and some businesses have made great use of the program, helping their employees get healthier while reducing health care costs and generally improving the quality of life for many. But it's about time LiveWell reached out to the broader business community. Most businesses, especially smaller ones, are too focused on their bottom line to spend much time thinking about how they can improve the health and wellness of their employees, but it should matter to them.
According to LiveWell Longmont's promotional materials, employer-sponsored health insurance premiums have risen four times faster than workers' earnings since 1989. Companies that have implemented comprehensive worksite wellness programs have seen a return on their investment of $3.27for every dollar spent.
Health matters, and most employers know this — but how many of them have much time to think about it?
At the breakfast, Kelly Brough, president and CEO of the Metro Denver Chamber of Commerce, laid out how she believes having a healthier work force can positively affect a business' bottom line.
A panel discussion during the breakfast featured representatives from LUH and Amgen, but I was disappointed that no small businesses — with the exception of Brough and the Denver Chamber — were represented. The majority of businesses are 50 employees and fewer, and for LiveWell Longmont to succeed in its mission, those are the companies it needs to hit. And to its credit, I think that was the point of the breakfast, although it didn't seem many of those businesses were in attendance.
Many local employers I know — including many small ones — do what they can to help their employees stay healthy, whether it's discounted rec center passes or posting fliers on how to quit smoking. But many probably feel overwhelmed with the simple act of staying in business. They may not feel like they have the time to promote health and wellness among their staffs.
But here's a plea from me: Make time. Employers, it's your people who drive your business' success. Do it for them.
Visit livewellcolorado.org and find "Longmont" under communities. Learn more about LiveWell Longmont. Call or email and find out how you can get involved.
Stay in touch at Tony Kindelspire, Longmont Times-Call on Facebook or @TKindelspireTC on Twitter.


text:
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Online political magazine against political correctness. this website is free and is open to anybody that wants to write for it. it is affiliated to no political party and is self funded.
it seeks to stir people's consciousness with a mixture of ser
3. A question of balance?
On line political magazine against political correctness and globalism. a political blog for ordinary people to speak their minds in an age whem politicians ignore the voters
4. A2z think tank
A community of thinkers! this a2z website is fairly new - but it's the one place you'll find top notch information on everything from a2z. and plus! they have free giv-a-ways every month!
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Aadivaaram.com is the first telugu e-magazine (electronic book format) on internet for telugu community around the world this website is provided by smart media syndicate from hyderabad, andhra pradesh in india and started in 2007.
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Nepal news,views and reviews, satier , humor and unlimited laughter
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Abacityblog is all about information and live trends, celebrity gossip, world news, entertainment news, nigerian new, relationship tips, new videos
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Originally teased a few days ago, the adidas originals nmd xr1 "duck camo" is the latest sneaker with a tonal white and black colour scheme. the upper is plastered with the latest duck camo, with a subtle palette to contrast the camo.
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The leading internet-magazine for leisure skippers and boating
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text:
If you smoke, don't bother applying for a job at Bert Fish Medical Center in New Smyrna Beach.
Starting Jan. 1, the hospital will no longer hire tobacco users.
The Daytona Beach News-Journal reports applicants will be tested for a nicotine byproduct and sign an agreement to remain tobacco-free throughout their employment. The policy doesn't apply to volunteers, medical staff or some 700 employees who are already working at the hospital.
In 2009 the hospital became a smoke-free campus. In January 2012, it started charging $25 per paycheck for smokers who elect to take health insurance.
If an employee hired after Jan. 1 tests positive for the nicotine byproduct will be subject to disciplinary action up to termination.
The hospital offers free tobacco-cessation counseling to employees and their families.
More Local Stories:
- Suspect Filmed Himself Having Sex With Sleeping Victim: Cops
- 1st-Grader Put on Wrong Bus Said "This Is Not My Stop"
- 30-Foot-Wide Sinkhole Found in Pasco County


text:
About this project
About The AVI CHAI Foundation
Inaugural Contest Winners (2011-2012)
The Sequel Winners (2012)
Contest Rules
Selecting the Winners
Enter the Contest
Watch & Rate Videos
Learn More >>
Free Alumni Contest Resources
One-on-One Consultations
Alumni Outreach Strategy
Video Production
Alumni Outreach Tactics
Resource Archive
Storytelling Resources
Production Resources
Post Production Resources
Distribution Resources
Tell Your Friends!
In our Alumni Edition contest, Jewish day schools
around the country teamed up with dedicated alumni
to tell their stories. After
public votes
and 10 judges' reviews, we have our winners!
1st Place:
Bernard Zell Anshe Emet Day School
Title: Revisiting BZAEDS: More than just a school
Location: Chicago, IL
Alumni Partners: Natalie Kaplan
Prize: $7,500
2nd Place:
Tarbut V' Torah
Title: Where will TVT bring you?
Location: Irvine, CA
Alumni Partners: Adam Cohen
Prize: $3,700
3rd Place:
Columbus Torah Academy
Title: How Do You Give Back?
Location: Columbus, OH
Alumni Partners: Rebecca Barnett, Jeremiah Pollack, Joel Greff
Prize: $2,500
1st Place:
Solomon Schechter Day School of Greater Boston
Title: A Schechter Student, A Schechter Alumnus: Jesse Wolf
Location: Newton, MA
Alumni Partners: Jesse Wolf
Prize: $3,000
Runner up:
The Frisch School
Title: Frisch's The Alumni
Location: Paramus, NJ
Alumni Partners: David Goldfischer, Jonathan Schachter, Jonathan Feldman, Maren Scharf, Rifkie Silverman, Eitan Kastner, Meryl Feldblum, Jonathan Spier, Mark Staum, Mark Infield, Josh Schulman, Larissa B. Leffel
Prize: $1,500
Runner up:
The Toronto Heschel School
Title: Heschel from the Heart
Location: Toronto, CA
Alumni Partners: Jonah Haber, Alex Esser
Prize: $1,500
Runner up:
Schechter Manhattan
Title: Alex Nisnewitz - My Schechter Manhattan Story
Location: New York, NY
Alumni Partners: Alex Nisnewitz
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Title: Shalom Y'all Rap
Location: New Orleans, LA
Alumni Partners: Max Vizelberg
Prize: $1,500
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This peptide is amino acids 48 to 57 fragment of TAT with an additional cysteine residue at the N-terminus. This peptide contains the protein transduction domain (PTD) of the HIV Tat protein that inhibits HSV-1 entry. The addition of a cysteine residue to the N-terminus of the Tat-PTD (Tat-C peptide) improves the antiviral activity against HSV-1 and HSV-2. Tat-C acts extracellularly, blocking entry of adsorbed virus immediately without eluting virions.
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A visit to the latest restaurant from New York's best-loved restaurateur, located in the Whitney Museum of American Art
After the long, long, flattering New York Times Magazine's profile of our Danny Meyer, which sets several scenes at the creation of his new Untitled restaurant in the lower level of the Whitney Museum, I thought I had to go see Untitled. Actually, I'd been planning to go anyway, as I spent the weekend in New York, and aside from wanting to see what Meyer did I've always liked museum restaurants. How could anyone not who grew up reading From the Mixed-Up Files of Mrs. Basil E. Frankweiler, in which a sister and brother sleep in the museum and bathe in the fountain in the restaurant, which supplies pocket change, too? It's not just the necessary respite museum restaurants offer from close concentration and (often feigned) reverence. It's the slightly illicit bonus of eating in a place you're not even supposed to touch anything and guards are watching you every minute.
Meyer made the restaurant at the renovated Museum of Modern Art, the Modern, one of the best places to eat in Midtown and also a place for a reliable power lunch. He was a shrewd choice of the directors, who knew he could anchor the restaurant exactly in the power structure that runs the city, as they themselves do.
The Whitney has always straddled a slightly odd balance: it shows art that should poke a sharp stick in the eye of the rich, smack in the middle of the staid-est, stodgiest silk-stocking district of the city. The last occupant of the Whitney was Sarabeth's Kitchen--a perfectly good choice for the Upper East Side neighborhood where the bakery/tearoom established its reputation, but not very ambitious. As he did at the Modern, Meyer has shrewdly looked to who lives and works nearby--the customers who can really keep the restaurant going--more than at the art. And he looked at the somber, dark-gray, modernist lines of the celebrated, stark 1966 Marcel Breuer building.
And so Meyer has chosen two things: a smooth, soothing, gray and brown palette with comfortable booths, and tables that can accommodate both power breakfasts and casual snack-seeking museum-goers, and food in the style of diner/luncheonette--which real East Siders know have always been the real places for power breakfasts and lunches in their neighborhood. Eggs, bagels and lox, BLTs, tuna melts, grilled cheese, pastrami reubens--these are extremely familiar territory for the supposedly fancy people who have always enjoyed economizing, and these days have an excuse to. And, of course, there are burgers. How could there not, given the huge success of Meyer's Shake Shacks?
(Side note: I went into the Upper West Side Shake Shack last night at about 10:00, scene of another Times Magazine Meyer visit, and didn't smell the aroma Meyer tells the author to sniff for as soon as he gets near a Shack--the Shacklike aura. Didn't smell anything, in fact. I took this as a sign of cleanliness and efficient ventilation, and the place was packed--including the "scrum," the small basement rec-room style seating area where there's a mercifully silent, big flat-screen TV showing, of course, sports. If Meyer wants to ventilate into the street the always-hunger-inducing aroma of new burgers, which I do associate with the original location in Madison Park--I just went this morning, and smelled the summerlike aromas of grilled cheese and ketchup, but not much burger grease--I'm sure he can arrange that too.)
I didn't have a chance to taste nearly enough at Untitled, because I could do only a pre-dinner on Saturday (the old restaurant-critic trick of two dinners in one night). On weekends, Untitled is offering three-course prix fixe dinners that hew much more closely to the Brooklynite, farm-to-table ethos Meyer says his team is bringing to the Upper East Side diner--though the breakfast-all-day/lunch-all-morning menu doesn't trumpet that farm-to-table connection. (It carefully looks like a standard diner/luncheonette menu, with salads-for-the-dieter choices thrown in.) My impression of the prix fixe dinner ($46) was that it's a work in progress: not diner-y at all, in fact much more like the immaculate little items as amuses-bouche you might get at the Modern, for instance a cheese biscuit filled with perfect cubes of raw salmon with a chive vinaigrette; lovely and small salads; and, for the main course, grilled quail marinated in a slightly spicy sauce with ketchup--the chef, Chris Bradley, has Southern roots, our waiter explained. The homemade spaetzle with more chives were the most memorable part of the main course, along with a slice of grilled local peach on fresh, peppery greens. For dessert, honey-lemon yogurt with figs. Very simple, very farm-to-table, very Brooklyn.
But the real heart of Untitled is that Upper East Side diner food I'll be back for next visit, with more Brooklynite credentials: Shack-influenced burgers; several kinds of grilled cheese on a parmesan-dusted, salty, heavy white loaf of "Parma" bread from the Brooklyn bakery Scratch; ice cream from Blue Marble, whose Prospect Heights location I visited yesterday for its very-high-butterfat products (dulce de leche is the way to go). And for a true look at how the Meyer team creates restaurants, I'll look again at Roger Sherman's The Restaurateur, the documentary that's now available on DVD and that shows the drama behind creating Tabla and 11 Madison Park.
And I'll be back for another order of what I'd been dreaming of since I first read of Meyer's plans to reinvent the diner: an egg cream. It wasn't on the evening menu, but Kevin Richer, the genial manager, got the kitchen in action, explaining that "Mr. Lauder insisted we have one on the menu"--Leonard Lauder, the longtime head of the Whitney's board, who apparently knows his egg creams. Richer said that the seltzer came from Ronny Beberman, the seltzer man separately celebrated in the Times, who, Richer says, has family connections with the sous chef. He brought a thick, heavy blue-green bottle to the table to show us the echt seltzer they use, and boasted of the house-made chocolate syrup and the "hand-crafting" of the egg creams.
I certainly admired the heavy parfait glass the egg cream came in, and the nearly inch-high layer of milk foam at the top. But the syrup? A bit faint in flavor, ever so slightly chalky on the aftertaste. I asked for another with Fox's U-Bet syrup, which Richer had assured me the kitchen kept on hand. And told him the truth when he asked which I preferred. Knowing the Meyer team, though, I fully expected that they'll have bested Fox's by the next time I visit. And I'm already saving up room for huckleberry buttermilk pancakes with a side of house-made bacon.
Images: Courtesy of Untitled
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(CNN) -- Former NBA star and TNT sports analyst Charles Barkley attended the Democratic National Convention on Tuesday and answered five questions for CNN.com at the CNN Grill.
Former NBA star Charles Barkley says the next president must deal with poverty and the war in Iraq.
CNN.com: Why are you here in Denver?
Barkley: I just wanted to be here. I'm just so excited. I never thought in my lifetime we'd have a black man with a legitimate shot of being president.
CNN.com: Are you a Barack Obama supporter?
Barkley: Barack has been a friend of mine for a long time. I met him when I was writing my last book, and he was running for Senate, and I got to know him, and we stayed in contact. I consider him a friend. I think he'd make a fantastic president. I want to make it clear that if I didn't think he could do the job, I wouldn't vote for him. I think he'd make a fantastic president. And I'm not voting for him because he's black. I think he's a great person.
CNN.com: What do you think the Democrats need to do here to win the White House?
Barkley: I think they've got to just make sure to get those troops home from Iraq, that's a big deal. But No. 1, we've got to give poor people a chance. America is divided by economics, and we as Americans, we've got to do a better job of supporting poor people.
CNN.com: How?
Barkley: We've got to improve the public school system. If you're born in this country poor, whether you're white or black, you're going to be born in a bad neighborhood; you're going to go to a bad school. It's going to be very difficult for poor people to be successful. iReport.com: Are you at the DNC? Share sights, sounds
CNN.com: What are you doing in Denver for fun?
Barkley: I'm going to the Hill Harper party tonight. Last night we just went out and had a real nice meal and just took it easy because I knew today was going to be a long day. I just want to be here. Plain and simple.
CNN.com: Are you running for governor in Alabama?
Barkley: I'm planning on running for governor. I can't screw up Alabama. Politics, it's just so important, and I just want to do good things with my name, and I'm just going to keep continuing to do that.


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Relatively quickly with a few searches, we figure out that GateKeeper was the messenger, but why was she being so harsh? Our apps are unsigned (a signature improvement slated for the next release), but damaged? I was offended.
As it turns out, Apple has a decent support article that explains why you might get a "damaged..." message versus GateKeeper's standard message warning the user that the application is unsigned.
The answer to softening GateKeeper's tone (AKA getting her to only prompt with a security message rather than a "damaged" message) lies within the info.plist file within the .app. Kurtis, our .app builder, found that if he sets the following values, then the .app reverts to being a harmless unsigned .app.
I hope this solution saves someone else the heartache of deploying a"damaged" .app file.
kindest regards,


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From Malinska located more than 50 miles of hiking trails along which you can see sights such as the monasteries in Porto or the old cemetery. Much of the promenade is suitable for cycling. And for those who like challenges throughout the year are organized several bicycle races. Pathways Malinska associated with other walks on the island.Walking along the shore, you can get up to 5 kilometers away Njivica and if you go way inland through beautiful natural setting you will reach Dobrinja or town of Krk. .
Beach Haludovo
Haludovo Beach is the most popular beach among children because it is shallow and completely sandy, which makes it ideal for playing in the shallows. A strong smell of pine trees and the sound of crickets are very significant and will walk through this part definitely relax.


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Pros: Fully mil-spec rugged, works 33 feet under water, great picture qualityCons: Nothing significantPerformance: A+Ease Of Use: A+Features: AValue: A-Price: $379The last time we looked at a rugged Olympus camera, the company was just getting into the market with the Stylus 1030 SW. It tested extremely well last year and, despite not looking very rough and tumble, survived everything we threw at it. Plus it took some amazing pictures. Apparently the public liked the camera as much as we did because Olympus now has an entire line of rugged cameras.
We brought the Stylus Tough-8000 into the lab because it's the new top-of-the-line model. We like how Olympus incorporated the word "tough" right into the name. There's no guessing as to their intent with this one.
The Tough-8000's specifications are almost identical to the 1030 SW's, but with slight improvements in the actual camera functions. The Tough-8000 is a 12 megapixel model; the 1030 is 10 megapixels. Everything else other than the color scheme is nearly identical. There is no change in the ruggedness rating of the new camera, thought we put it through our testing just in case.
It can survive Mil-Std 810F shock testing, meaning we dropped it from heights of up to six feet onto two inches of plywood sitting over concrete. Most of the time when you accidentally drop a camera, its going to be from a lower height, and you might even get lucky and have it clunk onto something soft. But the Tough-8000 can handle almost anything. It's like a little 3.7-inch by 2.4-inch brick that is only 0.85 inches thick. There are no moving parts other than a selector dial to take damage, and all the glass is protected within the metal housing.
Like the 1030, the Tough-8000 has a 2.7-inch LCD screen. You would think this would be vulnerable to breaking, but it's not. We dropped the Tough-8000 50 times directly onto its back, where the LCD sits, and never once came up with even a scratch. And the LCD screen can display some beautiful images. The screen is made up of 230,000 dots, so photos look, well, like photos when displayed there.
Another rugged feature that might come in handy is the camera's ability to work under water. It can go down to 33 feet according to the specifications, though the deepest water we could find was eight feet into a swimming pool. We left the camera on the bottom for a half-hour before bringing it back up. It didn't seem to mind and worked well once it resurfaced. We also took several pictures underwater, and they came out looking great.
We tested another new feature underwater: the tap sensor. If you want to review your photos or change settings on the camera, you can do so without pushing any buttons. A simple tap of the camera on the top or sides will advance the photos once or change the setting to the next level beside or down from your current menu selection. It's helpful underwater when you have a limited air supply but probably more useful when bundled up in a heavy coat and gloves. You can work with your camera without removing your gloves in a harsh environment.
And if you happen to be out in the cold, you don't have to leave your Tough-8000 behind. It can function down to 14 degrees Fahrenheit (-10 degrees Celsius) without freezing. We left it in a walk-in freezer for several hours that was just a few degrees above its specification and then took some great pictures of icy storage racks when we were finished.
Like the 1030, the Tough-8000 is easy to use. Tell it the type of environment that you will be shooting in, and it will fix all the settings for you. So you can get good pictures of a candlelight dinner or your friend skiing down a mountain by simply choosing that setting. It even has limited night-vision capabilities, with which it will capture any ambient light and form an image for your photo. And it can compensate for colored lights, eliminating the green tint that happens when shooting under florescent bulbs. It can slow down and capture motion extremely well or shoot in normal or wide-screen mode.
In short, it's easy to take professional shots in harsh environments or just around the office with almost no training or photography experience. There are even some special helper modes, such as automatically capturing faces in a portrait shot.
If you want to make a little movie, you can. The camera can capture an AVI movie with sound at 640 x 480 or 320 x 240. Both sizes for the video capture at 15 frames per second, so you aren't going to get a film-quality movie out of it, but the resulting images are still clear.
The flash on the Tough-8000 is adequate. We've never found a good flash for a digital camera, especially one that weighs only 6.5 ounces. But at least the software running the Tough-8000 knows its limitations and does its best to compensate. So you will get as good a picture as possible with a camera flash at that size, much better than you probably expect.
The camera runs on a lithium-ion rechargeable battery. With a full charge, we were able to get 215 pictures out of the unit. You are supposed to get as many as 250 pictures, but that depends on how much you use the LCD screen, which obviously drains the power. About 200 is more of an average between charges.
The Tough-8000 has 45M of internal memory, so it can store quite a few moderately sized pictures on its own. It takes both an xD-Picture Card (1G or 2G), or a microSD chip, as you would expect.
The Tough-8000 doesn't break new ground because the 1030 SW already did that, but it does push cameras a little bit further into the rugged space. And the retail price is only $379, so it's even a little cheaper than the 1030 was when it was released. If you are looking for a small, easy-to-use camera that is practically indestructible with normal use — and hearty when it is pushed — then you can't go wrong with the Tough-8000.
Olympus America, 978-468-8944, www.olympusamerica.com
About the Author
John Breeden II is a freelance technology writer for GCN.
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Induction of the cell cycle is emerging as an intervention to treat heart failure. Here, we tested the hypothesis that enhanced cardiomyocyte renewal in transgenic mice expressing cyclin D2 would be beneficial during hemodynamic overload. We induced pressure overload by transthoracic aortic constriction (TAC) or volume overload by aortocaval shunt in cyclin D2–expressing and WT mice. Although cyclin D2 expression dramatically improved survival following TAC, it did not confer a survival advantage to mice following aortocaval shunt. Cardiac function decreased following TAC in WT mice, but was preserved in cyclin D2–expressing mice. On the other hand, cardiac structure and function were compromised in response to aortocaval shunt in both WT and cyclin D2–expressing mice. The preserved function and improved survival in cyclin D2–expressing mice after TAC was associated with an approximately 50% increase in cardiomyocyte number and exaggerated cardiac hypertrophy, as indicated by increased septum thickness. Aortocaval shunt did not further impact cardiomyocyte number in mice expressing cyclin D2. Following TAC, cyclin D2 expression attenuated cardiomyocyte hypertrophy, reduced cardiomyocyte apoptosis, fibrosis, calcium/calmodulin–dependent protein kinase IIδ phosphorylation, brain natriuretic peptide expression, and sustained capillarization. Thus, we show that cyclin D2–induced cardiomyocyte renewal reduced myocardial remodeling and dysfunction after pressure overload but not after volume overload.
Karl Toischer, Wuqiang Zhu, Mark Hünlich, Belal A. Mohamed, Sara Khadjeh, Sean P. Reuter, Katrin Schäfer, Deepak Ramanujam, Stefan Engelhardt, Loren J. Field, Gerd Hasenfuss
Unbiased, "nontargeted" metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CT-defined nonalcoholic fatty liver disease (NAFLD) in the offspring cohort of the Framingham Heart Study (FHS) participants. We verified the relationship between DMGV and early hepatic pathology. Specifically, plasma DMGV levels were correlated with biopsy-proven nonalcoholic steatohepatitis (NASH) in a hospital cohort of individuals undergoing gastric bypass surgery, and DMGV levels fell in parallel with improvements in post-procedure cardiometabolic parameters. Further, baseline DMGV levels independently predicted future diabetes up to 12 years before disease onset in 3 distinct human cohorts. Finally, we provide all metabolite peak data consisting of known and unidentified peaks, genetics, and key metabolic parameters as a publicly available resource for investigations in cardiometabolic diseases.
John F. O'Sullivan, Jordan E. Morningstar, Qiong Yang, Baohui Zheng, Yan Gao, Sarah Jeanfavre, Justin Scott, Celine Fernandez, Hui Zheng, Sean O'Connor, Paul Cohen, Ramachandran S. Vasan, Michelle T. Long, James G. Wilson, Olle Melander, Thomas J. Wang, Caroline Fox, Randall T. Peterson, Clary B. Clish, Kathleen E. Corey, Robert E. Gerszten
Atherosclerosis is the underlying etiology of cardiovascular disease, the leading cause of death worldwide. Atherosclerosis is a heterogeneous disease in which only a small fraction of lesions lead to heart attack, stroke, or sudden cardiac death. A distinct type of plaque containing large necrotic cores with thin fibrous caps often precipitates these acute events. Here, we show that Ca2+/calmodulin-dependent protein kinase γ (CaMKIIγ) in macrophages plays a major role in the development of necrotic, thin-capped plaques. Macrophages in necrotic and symptomatic atherosclerotic plaques in humans as well as advanced atherosclerotic lesions in mice demonstrated activation of CaMKII. Western diet–fed LDL receptor–deficient (Ldlr–/–) mice with myeloid-specific deletion of CaMKII had smaller necrotic cores with concomitantly thicker collagen caps. These lesions demonstrated evidence of enhanced efferocytosis, which was associated with increased expression of the macrophage efferocytosis receptor MerTK. Mechanistic studies revealed that CaMKIIγ-deficient macrophages and atherosclerotic lesions lacking myeloid CaMKIIγ had increased expression of the transcription factor ATF6. We determined that ATF6 induces liver X receptor-α (LXRα), an Mertk-inducing transcription factor, and that increased MerTK expression and efferocytosis in CaMKIIγ-deficient macrophages is dependent on LXRα. These findings identify a macrophage CaMKIIγ/ATF6/LXRα/MerTK pathway as a key factor in the development of necrotic atherosclerotic plaques.
Amanda C. Doran, Lale Ozcan, Bishuang Cai, Ze Zheng, Gabrielle Fredman, Christina C. Rymond, Bernhard Dorweiler, Judith C. Sluimer, Joanne Hsieh, George Kuriakose, Alan R. Tall, Ira Tabas
The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete extracellular matrix proteins. Canonical TGF-β signaling mobilizes Smad2 and Smad3 transcription factors that control fibrosis by promoting gene expression. However, the importance of TGF-β–Smad2/3 signaling in fibroblast-mediated cardiac fibrosis has not been directly evaluated in vivo. Here, we examined pressure overload–induced cardiac fibrosis in fibroblast- and myofibroblast-specific inducible Cre-expressing mouse lines with selective deletion of the TGF-β receptors Tgfbr1/2, Smad2, or Smad3. Fibroblast-specific deletion of Tgfbr1/2 or Smad3, but not Smad2, markedly reduced the pressure overload–induced fibrotic response as well as fibrosis mediated by a heart-specific, latency-resistant TGF-β mutant transgene. Interestingly, cardiac fibroblast–specific deletion of Tgfbr1/2, but not Smad2/3, attenuated the cardiac hypertrophic response to pressure overload stimulation. Mechanistically, loss of Smad2/3 from tissue-resident fibroblasts attenuated injury-induced cellular expansion within the heart and the expression of fibrosis-mediating genes. Deletion of Smad2/3 or Tgfbr1/2 from cardiac fibroblasts similarly inhibited the gene program for fibrosis and extracellular matrix remodeling, although deletion of Tgfbr1/2 uniquely altered expression of an array of regulatory genes involved in cardiomyocyte homeostasis and disease compensation. These findings implicate TGF-β–Smad2/3 signaling in activated tissue-resident cardiac fibroblasts as principal mediators of the fibrotic response.
Hadi Khalil, Onur Kanisicak, Vikram Prasad, Robert N. Correll, Xing Fu, Tobias Schips, Ronald J. Vagnozzi, Ruijie Liu, Thanh Huynh, Se-Jin Lee, Jason Karch, Jeffery D. Molkentin
Defective protein quality control (PQC) systems are implicated in multiple diseases. Molecular chaperones and co-chaperones play a central role in functioning PQC. Constant mechanical and metabolic stress in cardiomyocytes places great demand on the PQC system. Mutation and downregulation of the co-chaperone protein BCL-2–associated athanogene 3 (BAG3) are associated with cardiac myopathy and heart failure, and a BAG3 E455K mutation leads to dilated cardiomyopathy (DCM). However, the role of BAG3 in the heart and the mechanisms by which the E455K mutation leads to DCM remain obscure. Here, we found that cardiac-specific Bag3-KO and E455K-knockin mice developed DCM. Comparable phenotypes in the 2 mutants demonstrated that the E455K mutation resulted in loss of function. Further experiments revealed that the E455K mutation disrupted the interaction between BAG3 and HSP70. In both mutants, decreased levels of small heat shock proteins (sHSPs) were observed, and a subset of proteins required for cardiomyocyte function was enriched in the insoluble fraction. Together, these observations suggest that interaction between BAG3 and HSP70 is essential for BAG3 to stabilize sHSPs and maintain cardiomyocyte protein homeostasis. Our results provide insight into heart failure caused by defects in BAG3 pathways and suggest that increasing BAG3 protein levels may be of therapeutic benefit in heart failure.
Xi Fang, Julius Bogomolovas, Tongbin Wu, Wei Zhang, Canzhao Liu, Jennifer Veevers, Matthew J. Stroud, Zhiyuan Zhang, Xiaolong Ma, Yongxin Mu, Dieu-Hung Lao, Nancy D. Dalton, Yusu Gu, Celine Wang, Michael Wang, Yan Liang, Stephan Lange, Kunfu Ouyang, Kirk L. Peterson, Sylvia M. Evans, Ju Chen
Atherosclerosis is a chronic inflammatory disease, and developing therapies to promote its regression is an important clinical goal. We previously established that atherosclerosis regression is characterized by an overall decrease in plaque macrophages and enrichment in markers of alternatively activated M2 macrophages. We have now investigated the origin and functional requirement for M2 macrophages in regression in normolipidemic mice that received transplants of atherosclerotic aortic segments. We compared plaque regression in WT normolipidemic recipients and those deficient in chemokine receptors necessary to recruit inflammatory Ly6Chi (Ccr2–/– or Cx3cr1–/–) or patrolling Ly6Clo (Ccr5–/–) monocytes. Atherosclerotic plaques transplanted into WT or Ccr5–/– recipients showed reduced macrophage content and increased M2 markers consistent with plaque regression, whereas plaques transplanted into Ccr2–/– or Cx3cr1–/– recipients lacked this regression signature. The requirement of recipient Ly6Chi monocyte recruitment was confirmed in cell trafficking studies. Fate-mapping and single-cell RNA sequencing studies also showed that M2-like macrophages were derived from newly recruited monocytes. Furthermore, we used recipient mice deficient in STAT6 to demonstrate a requirement for this critical component of M2 polarization in atherosclerosis regression. Collectively, these results suggest that continued recruitment of Ly6Chi inflammatory monocytes and their STAT6-dependent polarization to the M2 state are required for resolution of atherosclerotic inflammation and plaque regression.
Karishma Rahman, Yuliya Vengrenyuk, Stephen A. Ramsey, Noemi Rotllan Vila, Natasha M. Girgis, Jianhua Liu, Viktoria Gusarova, Jesper Gromada, Ada Weinstock, Kathryn J. Moore, P'ng Loke, Edward A. Fisher
Congenital heart disease (CHD) represents the most prevalent inborn anomaly. Only a minority of CHD cases are attributed to genetic causes, suggesting a major role of environmental factors. Nonphysiological hypoxia during early pregnancy induces CHD, but the underlying reasons are unknown. Here, we have demonstrated that cells in the mouse heart tube are hypoxic, while cardiac progenitor cells (CPCs) expressing islet 1 (ISL1) in the secondary heart field (SHF) are normoxic. In ISL1+ CPCs, induction of hypoxic responses caused CHD by repressing
Xuejun Yuan, Hui Qi, Xiang Li, Fan Wu, Jian Fang, Eva Bober, Gergana Dobreva, Yonggang Zhou, Thomas Braun
Philipp S. Wild, Janine F. Felix, Arne Schillert, Alexander Teumer, Ming-Huei Chen, Maarten J.G. Leening, Uwe Völker, Vera Großmann, Jennifer A. Brody, Marguerite R. Irvin, Sanjiv J. Shah, Setia Pramana, Wolfgang Lieb, Reinhold Schmidt, Alice V. Stanton, Dörthe Malzahn, Albert Vernon Smith, Johan Sundström, Cosetta Minelli, Daniela Ruggiero, Leo-Pekka Lyytikäinen, Daniel Tiller, J. Gustav Smith, Claire Monnereau, Marco R. Di Tullio, Solomon K. Musani, Alanna C. Morrison, Tune H. Pers, Michael Morley, Marcus E. Kleber, AortaGen Consortium, Jayashri Aragam, Emelia J. Benjamin, Joshua C. Bis, Egbert Bisping, Ulrich Broeckel, CHARGE-Heart Failure Consortium, Susan Cheng, Jaap W. Deckers, Fabiola Del Greco M, Frank Edelmann, Myriam Fornage, Lude Franke, Nele Friedrich, Tamara B. Harris, Edith Hofer, Albert Hofman, Jie Huang, Alun D. Hughes, Mika Kähönen, KNHI investigators, Jochen Kruppa, Karl J. Lackner, Lars Lannfelt, Rafael Laskowski, Lenore J. Launer, Margrét Leosdottir, Honghuang Lin, Cecilia M. Lindgren, Christina Loley, Calum A. MacRae, Deborah Mascalzoni, Jamil Mayet, Daniel Medenwald, Andrew P. Morris, Christian Müller, Martina Müller-Nurasyid, Stefania Nappo, Peter M. Nilsson, Sebastian Nuding, Teresa Nutile, Annette Peters, Arne Pfeufer, Diana Pietzner, Peter P. Pramstaller, Olli T. Raitakari, Kenneth M. Rice, Fernando Rivadeneira, Jerome I. Rotter, Saku T. Ruohonen, Ralph L. Sacco, Tandaw E. Samdarshi, Helena Schmidt, Andrew S.P. Sharp, Denis C. Shields, Rossella Sorice, Nona Sotoodehnia, Bruno H. Stricker, Praveen Surendran, Simon Thom, Anna M. Töglhofer, André G. Uitterlinden, Rolf Wachter, Henry Völzke, Andreas Ziegler, Thomas Münzel, Winfried März, Thomas P. Cappola, Joel N. Hirschhorn, Gary F. Mitchell, Nicholas L. Smith, Ervin R. Fox, Nicole D. Dueker, Vincent W.V. Jaddoe, Olle Melander, Martin Russ, Terho Lehtimäki, Marina Ciullo, Andrew A. Hicks, Lars Lind, Vilmundur Gudnason, Burkert Pieske, Anthony J. Barron, Robert Zweiker, Heribert Schunkert, Erik Ingelsson, Kiang Liu, Donna K. Arnett, Bruce M. Psaty, Stefan Blankenberg, Martin G. Larson, Stephan B. Felix, Oscar H. Franco, Tanja Zeller, Ramachandran S. Vasan, Marcus Dörr
Diseases caused by gene haploinsufficiency in humans commonly lack a phenotype in mice that are heterozygous for the orthologous factor, impeding the study of complex phenotypes and critically limiting the discovery of therapeutics. Laboratory mice have longer telomeres relative to humans, potentially protecting against age-related disease caused by haploinsufficiency. Here, we demonstrate that telomere shortening in NOTCH1-haploinsufficient mice is sufficient to elicit age-dependent cardiovascular disease involving premature calcification of the aortic valve, a phenotype that closely mimics human disease caused by NOTCH1 haploinsufficiency. Furthermore, progressive telomere shortening correlated with severity of disease, causing cardiac valve and septal disease in the neonate that was similar to the range of valve disease observed within human families. Genes that were dysregulated due to NOTCH1 haploinsufficiency in mice with shortened telomeres were concordant with proosteoblast and proinflammatory gene network alterations in human NOTCH1 heterozygous endothelial cells. These dysregulated genes were enriched for telomere-contacting promoters, suggesting a potential mechanism for telomere-dependent regulation of homeostatic gene expression. These findings reveal a critical role for telomere length in a mouse model of age-dependent human disease and provide an in vivo model in which to test therapeutic candidates targeting the progression of aortic valve disease.
Christina V. Theodoris, Foteini Mourkioti, Yu Huang, Sanjeev S. Ranade, Lei Liu, Helen M. Blau, Deepak Srivastava
Ischemic heart disease resulting from myocardial infarction (MI) is the most prevalent form of heart disease in the United States. Post-MI cardiac remodeling is a multifaceted process that includes activation of fibroblasts and a complex immune response. T-regulatory cells (Tregs), a subset of CD4+ T cells, have been shown to suppress the innate and adaptive immune response and limit deleterious remodeling following myocardial injury. However, the mechanisms by which injured myocardium recruits suppressive immune cells remain largely unknown. Here, we have shown a role for Hippo signaling in the epicardium in suppressing the post-infarct inflammatory response through recruitment of Tregs. Mice deficient in epicardial YAP and TAZ, two core Hippo pathway effectors, developed profound post-MI pericardial inflammation and myocardial fibrosis, resulting in cardiomyopathy and death. Mutant mice exhibited fewer suppressive Tregs in the injured myocardium and decreased expression of the gene encoding IFN-γ, a known Treg inducer. Furthermore, controlled local delivery of IFN-γ following MI rescued Treg infiltration into the injured myocardium of YAP/TAZ mutants and decreased fibrosis. Collectively, these results suggest that epicardial Hippo signaling plays a key role in adaptive immune regulation during the post-MI recovery phase.
Vimal Ramjee, Deqiang Li, Lauren J. Manderfield, Feiyan Liu, Kurt A. Engleka, Haig Aghajanian, Christopher B. Rodell, Wen Lu, Vivienne Ho, Tao Wang, Li Li, Anamika Singh, Dasan M. Cibi, Jason A. Burdick, Manvendra K. Singh, Rajan Jain, Jonathan A. Epstein


text:
Hugh Keenleyside interview collection (Peter Stursberg collector)
- Collection
- 1980
Journalist Peter Stursberg interviewed Hugh Keenleyside as part of an oral history project for the Parliamentary Library and the National Archives of Canada. Dr. Keenleyside was a former chair of the B.C. Power Commission and played an important r...
Stursberg, Peter


text:
Undeterred by past failures, the U.S. Defense Advanced Research Projects Agency (Darpa) is launching another attempt to develop a high-speed vertical-takeoff-and-landing (VTOL) aircraft with the hover capability of a helicopter.
The VTOL X-Plane program is a 52-month, $130 million effort to fly an experimental aircraft capable of exceeding 300 kt., but with a hover efficiency of 75% or better and a cruise lift-to-drag ratio of 10 or more. By comparison, according to Darpa, today's conventional helicopters are capable of 150-170 kt., with a hover efficiency of 60% and a cruise L/D of 4-5.
High-speed compound helicopters such as Sikorsky's X2 are capable of 240-260 kt., while the Bell Boeing V-22 tiltrotor can exceed 275 kt., but with low hover efficiency.
"We have a simple objective: to fly much faster, with improved efficiency in hover and forward flight, without sacrificing the ability to do useful work," says Ashish Bagai, Darpa program manager and former Sikorsky principal engineer.
Useful work is defined as the difference between empty weight and maximum gross weight, he says. The program is targeting a useful load of at least 40% of gross weight, which is expected to be 10,000-12,000 lb. for the X-plane demonstrator.
This compares with a useful load of 35-40% of gross weight for a state-of-the-art helicopter, according to Darpa.
Bagai says Darpa is looking for "elegant" designs combining the attributes of fixed- and rotary-wing aircraft, that are "not overly complex and not brute-force approaches," he says. A broad agency announcement has been released, and Darpa is hoping to attract proposals from nontraditional companies and "exotic ideas from smaller companies on technologies, agile teaming and rapid design," he says.
This is not the agency's first attempt to develop a high-speed VTOL aircraft. The canard rotor/wing Boeing X-50A Dragonfly was designed to demonstrate a circulation-control rotor that could be stopped in flight to act as a fixed wing. Both subscale unmanned demonstrators crashed before transition could be achieved and the program was terminated in 2006.
The Groen Heliplane was a high-speed gyroplane design with a rotor that was powered by tipjets for vertical takeoff and landing and autorotated in forward flight at speeds up to 350 kt. The program encountered technical challenges with noise from the tipjets and was terminated in 2008.
-- This article first appeared in Aerospace Daily & Defense Report.


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How to Capture Close-Ups in Digital Wedding Photography
Though a wedding has a lot of fast-paced movement for a photographer to capture, it also has quiet times that present golden opportunities for some really great photos. Some of the most iconic pictures of most weddings, like a portrait of the bride in her dress or a candid of the couple in an unrehearsed embrace, come from these calm moments.
How to select an aperture for a close-up
Choosing an aperture is one of the first elements you decide when shooting the still moments. Aperture is one of the factors that determine your depth of field, or how much of the picture is acceptably sharp. Depth of field is used to create mood by softening or hardening the foreground and background of your photo.
When shooting a single subject, photographers have different preferences. When deciding what to do, consider the information in the following list, which addresses apertures f/1.2 to f/11 and how they create certain effects. Pick and choose what you want to use based on your circumstances and artistic style.
f/1.2 to f/2: These widest possible apertures are best used for a single subject. They result in a very shallow depth of field, which isolates your subject from the foreground and background. They can create a very soft and dreamy look.50mm, 1/200 sec., f/1.4, 100
If you're shooting a portrait, be aware that a person's face will not be entirely in focus with apertures this wide.
f/2.8 to f/4: These apertures also give you a shallow depth of field but allow more of a person's face to be in focus. For a single subject, if you start around f/2.8, most of the face is sharp, but the ears are softly focused. If you go up to f/4, you can get the entire head in focus.
If you're photographing two people, start at a minimum of f/4 to ensure that both people are acceptably sharp in the picture.
f/4.5 to f/5.6: For a single subject, f/4.5 to f/5.6 begins to add sharpness to the entire subject but also includes more of the background.
This aperture range works well for pictures of two people and small groups.
f/6.3 to f/8: These apertures add increasing sharpness to a single subject as well as add in more of the foreground and background.
This aperture range also can be used for larger-group photos with several rows of people.
f/9 to f/11: A single subject photographed with this aperture range is very sharp. The foreground and background are sharp as well.50mm, 1/40 sec., f/11, 800
This range also can be used for very large group photos, such as the couple and all the wedding guests.
Play around with apertures and depth of field to find what looks best to you.
How to capture a close-up by focusing on the eyes
As you photograph people on a wedding day and capture their expressions, keep in mind that the eyes are the strongest focal point of a photo of a person.
If your subject is looking at the camera, the eyes are the most crucial part of the picture to have tack sharp (highest clarity and detail possible) and well lit. Here are a few ways you can make eyes pop in a photograph:
Using single-shot mode: If your subject is standing still, single-shot mode is very helpful when focusing on the eyes. Single-shot mode works well because when you press the shutter-release button halfway down, it locks the focus until you take the picture.
Taking advantage of your autofocus points: Rather than using the center autofocus point to lock the focus and then recomposing, consider using the different autofocus points available. Move the point to the center of one of your subject's eyes.
Smiling with the eyes: Without a smile on her face or in her eyes, a person can look sad, depressed, or even angry. To smile with the eyes, have your subject raise her eyebrows slightly and open her eyes a little bit. You can also tell her to think about how happy she is and to communicate that with her eyes.50mm, 1/250 sec., f/1.6, 125
Creating catchlights: One of the biggest ways to make your subject's eyes come to life is to give them a little gleam with catchlights. Catchlights are reflected light in the eyes, and you can capture this effect if you're aware of the light source and make sure that enough is present to provide that reflection.
When you figure out where your light is coming from, angle your subject toward the light to give the eyes a little oomph.28mm, 1/100 sec., f/2.8, 125
How to choose angles and framing for close-up portraits
To prevent your pictures of the calm moments from becoming static or boring, consider switching your angles and in-camera framing to add interest to the photo.
Angles: Most portraits are taken from an eye-level point of view, so changing your angle can show different details, especially when shooting close-ups. Try standing up on a chair and shooting your subject from above or getting down on the ground and shooting up at your subject.50mm, 1/160 sec., f/4.0, 100
In-camera framing: If you find yourself getting stuck shooting in portrait mode or in landscape mode, try switching it up to add variety to your photos.
How to play with lighting for a close-up photo
Lighting can have a huge impact on your photos by creating different moods. When you combine certain types of lighting with expressions, you can create photographs that draw in a viewer.
Side lighting: When you light a subject with a neutral expression from the side, it can add a very dramatic effect to a photograph.38mm, 1/50 sec., f/3.2, 160
Backlighting: Backlighting, especially in golden sunlight, can convey a sense of warmth, happiness, and romance, highlighting the emotions already present.50mm, 1/640 sec., f/3.5, 125


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East Coast USA is hitting the road for our 2017 Pageant Tour! Join us for your chance to WIN BIG at East Coast USA and win one of prestigious state titles to begin your journey to the National Finals 2017! Only 10 contestants are accepted per age division so register TODAY to secure your spot. If your division is full your deposit will be refunded within 24 hours.
First registered get the spots as contestants. We enjoy getting to know our contestants and their families!
The East Coast USA Pageant gives away over $100,000.00 annually in cash and prizes! When you attend one of our events you can expect a well-run competition and quality prizes. We pride ourselves on our professionalism, attention to detail and the experience of each individual contestant that walks across our stage. In addition we have a team dedicated to providing our contestants and winners with unique opportunities to get involved with their community, print modeling jobs, runway shows, acting careers, attend VIP concerts, Good Morning America and so much more! Join our Fan Page on Facebook to keep up with all of the latest appearances and happenings. https://www.facebook.com/eastcoastusapageant
Join us for our NEW JERSEY PAGEANT!
New Jersey Pageant: April 30, 2017CLICK HERE TO REGISTER
Hilton Parsippany Hotel
1 Hilton Court
Parsippany, NJ 07054
Phone: (973) 267-7373
Produced By National Director: Lauren Handler
All Contestants will Compete in the Following Three Areas of Competition:
This is your time to shine! All contestants will compete in this competition. Contestants will do a simple walk on the stage. The stage will be in the shape of a T crossing at the back. There will be four X's marked on the stage. Contestants should stop at each X marked on the stage and turn at either all of the X's or the ones of their choosing. Our emcee will read about them to the audience. All contestants up to age 11 yrs. can wear a short or long dress. Ages 12 yrs. and over should wear a floor length evening gown. NO CUPCAKE STYLE GLITZ DRESSES PLEASE for children please. Stones are allowed on all dresses. We supply the music. Judging will be based on facial beauty, stage presence personality and overall appeal.
Contestants Ages 0-11 years are not permitted to wear any make-up. Clear lip gloss and clear mascara are allowed only. They are not allowed to use false tanning, eyelashes, flippers, falls, wiglets or hair pieces when competing in any of the onstage events. If your child wears braids or hair extensions in their hair as part of their EVERYDAY look that is ok to compete with at East Coast USA. We also understand that some children have medial conditions that require them to wear a hair piece. Please bring this to the attention of the director for assistance. Contestants are checked to make sure they are following the guidelines before they go on-stage.
Time Limit: 1 minute
Group Line Up
Each age division will come onstage together before they compete individually. They will line up across the back of the stage and smile for the judges as they score the beauty side awards. This also gives the judges a chance to access the group as a whole.
A parent, sibling or friend of each toddler contestant 0-3 yrs. is allowed on stage with them at all times.
This is a free style runway modeling event. Attire should be a trendy "boutique" outfit or a high fashion "vogue" look. Choose an outfit that showcases your personality. This is your chance to show the judges your unique style and have fun! The music will be fast and upbeat and we supply the music. Contestants should stop at each X on the stage, strike a pose, turn and/or show some personality! Hand held props may be used. Judging will be based on personality, modeling ability and overall appearance. Time Limit: 1 minute
Photo Sizes: 8-10" or 8.5-11" This should be a head shot. It can be black and white or color. You will bring your photo with you to registration with your full name and age on the back. Light make up is allowed by all ages for your head shots. Photos may be lightly retouched, cropped and/or have lighting adjusted. NO "GLITZ" PHOTOS PLEASE. Judging will be based on personality projection, facial beauty, overall appeal, quality and clarity.
*Score sheet available immediately after the awards ceremony. All Photogenic entries will be returned as well.
Wee Baby Miss: 2-12 months
Baby Miss: 13-23 months
Tiny Toddler Miss: 2 years
Wee Toddler Miss: 3 years
Toddler Miss: 4 years
Tiny Miss: 5 years
Mini Miss: 6-7 years
Little Miss: 8-9 years
Pre-Teen: 10-11 years
Jr. Miss 12-13 years
Young Miss 14-16 years
Teen Miss 17-19 years
Miss 20-28 years
Age as of April 30, 2017
You do not need to live in New Jersey to compete in the competition.
A dressing room for contestants will be provided at each event. There are no men permitted in the dressing rooms.
Tickets will be available for purchase at registration. Pre-Order your tickets to receive them discounted.
Supreme Package: Beauty, Runway & Photogenic and One Admission Adult Pass: $145
Pageant Day Tentative Schedule
Sunday, April 30, 2017
Baby & Toddler 0-5 yrs. Virginia East Coast USA Pageant
8:00-9:45 am Registration and Onstage Practice
10:00 am Runway Competition
Wee Baby Miss: 2-12 months
Baby Miss: 13-23 months
Tiny Toddler Miss: 2 years
Wee Toddler Miss: 3 years
Toddler Miss: 4 years
Tiny Miss: 5 years
11:00 am Beauty Competition
Wee Baby Miss: 2-12 months
Baby Miss: 13-23 months
Tiny Toddler Miss: 2 years
Wee Toddler Miss: 3 years
Toddler Miss: 4 years
Tiny Miss: 5 years
12:30 Lunch & Tabulation Break
1:00 pm Crowning Ceremony!
Please wear your beauty dress to crowning. New title holders must stay for photos. Score sheet and photos are available for pick up immediately following the crowning ceremony.
Girls & Ladies 6-28 yrs. Virginia East Coast USA Pageant
1:00-2:30 pm Registration
2:15 pm Onstage Practice
3:00 pm Runway Competition
6-7 yrs.
8-9 yrs.
10-11 yrs.
12-13 yrs.
14-16 yrs.
17-19 yrs.
20-28 yrs.
4:00 pm Beauty Competition
6-7 yrs.
8-9 yrs.
10-11 yrs.
12-13 yrs.
14-16 yrs.
17-19 yrs.
20-28 yrs.
5:30-6:00 pm Tabulation Break & Star Gazer Fashion Show
6:00 pm Pageant Crowning Ceremony!
Please wear your beauty dress to crowning. New title holders must stay for photos. Score sheet and photos are available for pick up immediately following the crowning ceremony.
We can't wait to have you join us!
3 GRAND SUPREME QUEENS (0-5 yrs., 6-11 yrs. and 12 yrs. +)
The contestant with the highest combined scores from the Beauty Competition+Runway Competition+Photogenic Competition will be crowned the Grand Supreme! She will win a Large Rhinestone Custom Crown, Satin Embroidered Banner, $500 U.S. Savings Bond, Rhinestone Scepter, Gifts and a $200 Gift Certificate toward the National Finals July 28-30, 2017 in Parsippany, New Jersey!
13 Age Divisional Beauty Queens
The contestant with the highest beauty competition score per age division will be crowned the beauty queen and take home the state title! She will also win a Large Rhinestone Custom Crown, Satin Embroidered Banner, Gifts and $200 Gift Certificate toward the National Finals July 28-30, 2017 in Parsippany, New Jersey!
52 Beauty Runners-Up
In each age division we will award 4 Runner-Ups making a Queen's Court. They will each receive a beautiful rhinestone crown, gift, award and a $100 Gift Certificate toward the National Finals July 28-30, 2017 in Parsippany, New Jersey!
26 Event Winners
In each age division we will award a winner for Runway and Photogenic. They will each receive an award and gift!
65 Shinning Beauty Awards
We will award a winner for Prettiest Eyes, Hair, Smile, Best Dressed and Best Personality in each age division. They will receive awards and gifts!
Being crowned an East Coast USA state Queen is an amazing opportunity. Should you be selected as a title holder (Supreme or Divisional) here is what you need to know about your year and what is expected of our royalty:
– No poor sportsmanship will be tolerated from any contestants or families. Those displaying acts of poor sportsmanship will be asked to leave without a refund and will not be permitted to return.
– All Supreme and Divisional title holders MUST compete at the 2017 East Coast USA National Finals July 28-30, 2017 in Parsippany, New Jersey. If you cannot attend the national pageant, you will forfeit the title. All cash awards, prizes, trophies, and the crown and banner must be returned to the pageant office immediately. State monetary awards will be presented at the 2017 National Finals Registration.
– East Coast USA is looking for ROLE MODELS. You will be expected to represent East Coast USA in the best way possible. This includes acting appropriately when using social media outlets such as Facebook, Twitter and Instagram.
– You are required to return to the state pageant the following year and crown your successor.
– Should you be crowned it is encouraged that you attend East Coast USA appearances and seek out your own. You could WIN AGAIN! BIG! As we will be presenting CASH SCHOLARSHIPS at the 2017 National Finals for acts of volunteerism that you participate in with your East Coast USA crown and sash!
– Have fun! This is a family oriented competition where the sky is the limit with the amazing opportunities we offer. Make your experience one to remember!


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Loading Pathway...
Error: Pathway image not found.
Pathway Description
Cardiolipin Biosynthesis CL(14:1(11Z)/14:1(11Z)/16:1(11Z)/28:1(11Z))
Saccharomyces cerevisiae
Metabolic Pathway
The biosynthesis of cardiolipin begins in the endoplasmic reticulum. Glycerone phosphate interacts with a NADPH resulting in the release of NADP and glycerol 3-phosphate. Glycerol 3-phoshate reacts with Glycerol-3-phosphate O-acyltransferase resulting in the release of 1-palmitoylglycerol 3-phosphate. The resulting compound reacts with an acyl-CoA through a oleoyl-CoA: lysophosphatidate acyltransferase resulting in the release of a Phosphatidic Acid. Phosphatidic Acid is transported to the mitochondrial outer membrane. Once in, it gets transported into the mitochondrial inner membrane. The phosphatidic acid reacts with cytidine triphosphate through a phosphatidate cytidyltransferase resulting in the release of a CDP-DG. The resulting compound reacts with a glycerol 3-phosphate through a CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase resulting in the release of cytidine monophosphate and PGP. PGP reacts with Phosphatidylglycerophosphatase GEP4, mitochondrial resulting in the release of PG. PG reacts with a CDP-DG through a Cardiolipin synthase (CMP-forming) resulting in the release of CL and cytidine monophosphate. CL reacts with lipase cldp1 resulting in the release of 1-MLCL. This in gets transformed into the isomer 2-MLCL. This in turn can either react with an transacylase TAZ1P resulting in the release of CL or it can be transported to the mitochondrial outer membrane where it reacts with a transacylase TAZ1P resulting in the release of a cardiolipin.
Cardiolipin Biosynthesis CL(14:1(11Z)/14:1(11Z)/16:1(11Z)/28:1(11Z)) References
This pathway was generated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Generated from PW002431
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Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
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Early Ford V-8 Club Forum
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Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01245335
Recruitment Status : Completed
First Posted : November 22, 2010
Last Update Posted : December 15, 2015
- Study Details
- Tabular View
- Results Submitted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Critical Limb Ischemia
|Device: BMAC injection Device: Placebo injection
|Phase 3
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|97 participants
|Intervention Model:
|Parallel Assignment
|Double (Participant, Investigator)
|Primary Purpose:
|Official Title:
|Pivotal Study of the Safety and Effectiveness of Autologous Bone Marrow Aspirate Concentrate (BMAC) for the Treatment of Critical Limb Ischemia Due to Peripheral Arterial Disease
|Study Start Date :
|May 2011
|Actual Primary Completion Date :
|August 2015
|Actual Study Completion Date :
|November 2015
Active Comparator: BMAC Treatment
Intervention- Injection of 40 ml of autologous bone marrow concentrate (BMAC injection) prepared with the SmartPReP2 BMAC System
Device: BMAC injection
Injection of 40 ml of autologous bone marrow aspirate concentrate (BMAC injection) prepared with the SmartPReP2 BMAC System
Placebo Comparator: Placebo Injection
Injection of placebo (diluted peripheral blood) into ischemic tissue of the lower extremity
Device: Placebo injection
Injection of placebo into ischemic tissue of the lower extremity
- Amputation Free Survival [ Time Frame: Six Months ]Survival without a major (above the ankle) amputation
- Change In Rutherford Classification [ Time Frame: Six Months ]Change in the subjects clinical status as measured by Rutherford Classification
- Change in Pain [ Time Frame: Six Months ]Change in Subjects perception of pain as measured on a 100 mm visual analog scale
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patient has Peripheral Arterial Occlusive Disease (PAOD) with clinical Rutherford Category 5 disease, as defined in the reporting standards adopted by the Society of Vascular Surgeons(table 1); Minor Tissue loss-focal gangrene with diffuse pedal ischemia
Patient meets at least one of the following diagnostic criteria in the study limb:
- Ankle artery occlusion pressure absolute ≤60 mmHg or ABI ≤0.6
- Toe artery occlusive pressure < 50mm Hg or TBI ≤0.6
There is no reasonable open surgical or endovascular revascularization option as determined by the treating vascular specialist. Factors that may contribute to the determination of inoperability may include:
- Anatomical considerations
- No outflow targets
- No appropriate conduit (i.e. vein for bypass)
Long segment occlusions or calcified lesions that predict poor outcome with endovascular approaches.
- High risk medical conditions i.e. Unstable cardiac disease.
- History of prior failed revascularization attempts
- The Patient's case was reviewed at the treating institution's Multidisciplinary Vascular Conference where the patient's status as a poor candidate for conventional therapies was confirmed.
- Age ≥18 years and ability to understand the planned treatment
- Subject has read and signed the IRB approved Informed Consent form
- Patients for whom the following medication(s) is prescribed must have a one month stable baseline therapy prior to enrollment: Plavix/asprin therapy, anticoagulation therapy, cholesterol lowering agent, and or blood pressure medication. If any of these medications are not prescribed notation of the reason for omission is to be provided.
- Hematocrit ≥ 28.0%, White Blood Cell count ≤ 14,000, Platelet count ≥ 50,000, Creatinine ≤ 2.5 mg / dL, INR ≤ 1.6 unless on Coumadin, or PTT <1.5 x control (to avoid bleeding complications) Patients on Coumadin will be corrected prior to the procedure and must have an INR<1.6 at the time of randomization/surgery.
Exclusion Criteria:
- Life expectancy <6 months due to concomitant illnesses
- History of bone marrow diseases (especially NHL, MDS) that prohibit transplantation
- Terminal renal failure with existing dependence on dialysis or serum creatinine >2.5 mg/dL
- Known active malignancy or results outside of normal limits from the following tests: PAP, Chest X-ray, PSA, Mammogram, Hemocult unless follow-up studies reveal patient to be cancer free.
- Poorly controlled diabetes mellitus (HgbA1C>10%)
- Medical risk that precludes anesthesia (conscious sedation), or ASA Class 5
- Life-threatening complications of the ischemia necessitating immediate amputation
- Uncorrected occlusion of the common or external iliac artery on index side
- Absence of any pulsatile Doppler flow below the ankle.
- Extensive necrosis of the index limb or other conditions that make amputation inevitable (Rutherford Category 6).
- Ulceration with exposed bone proximal to the distal metatarsal heads (ie. heel or mid foot)
- Active clinical infection or infection being treated by antibiotics within one week of enrollment
- Treatment with immunosuppressant drugs (including Prednisone > 5 mg per day).
- Female who is pregnant or nursing, or of child bearing potential and is not using a reliable birth control method.
- Underwent a major open cardiovascular surgical procedure (carotid endarterectomy, arterial aneurysm or bypass surgery, or coronary artery bypass surgery) or a myocardial infarction within the 3 months prior to randomization
- Underwent a successful or partially successful endovascular intervention for peripheral arterial occlusive disease. (ie. Aorta, iliac, femoral, popliteal, or tibial artery angioplasty, stenting, or atherectomy) within the prior 3 months.
- Endovascular coronary intervention (ie. Angioplasty, atherectomy, stenting) within 1 month prior to randomization.
Underwent a failed attempt for endovascular revascularization during the prior 1 month. For the purpose of this exclusion criteria an endovascular procedure is considered a failure if:
- The procedure is diagnostic only with no intervention performed, (for example in the case where wire crossing can not be obtained).
- The treated artery recoils, thromboses, or dissects resulting in occlusion of the treated arterial segment, documented by intraoperative imaging. Note that endovascular procedures with suboptimal results but not meeting criteria 1 or 2 above may qualify for inclusion after 3 months as in #16 above.
- Cerebrovascular accident within 6 months prior to randomization.
- Treatment with topical growth factors or hyperbaric oxygen (HBO) within 30 days, or systemic growth factor treatment within 6 months of enrollment.
- Known hypersensitivity to heparin; or history of heparin-induced thrombocytopenia (HIT).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01245335
Hide Study Locations
|United States, Alabama
|University of Alabama
|Birmingham, Alabama, United States, 35294-0012
|United States, Arkansas
|Medical Center of South Arkansas
|El Dorado, Arkansas, United States, 71730
|United States, California
|USC Keck School of Medicine
|Los Angeles, California, United States, 90033
|United States, Florida
|Florida Hospital - Vascular Institute of Central Florida
|Orlando, Florida, United States, 32804
|Coastal Vascular & Interventional
|Pensacola, Florida, United States, 32503
|USF / Tampa General
|Tampa, Florida, United States, 33606
|United States, Illinois
|University of Illinois-Chicago
|Chicago, Illinois, United States, 60612
|Cadence Health, Central DuPage Hospital
|Winfield, Illinois, United States, 60190
|United States, Louisiana
|Ochsner Clinic
|New Orleans, Louisiana, United States, 70121
|United States, Maine
|Maine Medical Ctr
|Portland, Maine, United States, 04102
|United States, Maryland
|Johns Hopkins Hospital
|Baltimore, Maryland, United States, 21287
|United States, Massachusetts
|Tufts Medical Center
|Boston, Massachusetts, United States, 02111
|Beth Israel Deaconess
|Boston, Massachusetts, United States, 02215
|United States, Missouri
|Kansas City Vascular
|Kansas City, Missouri, United States, 64116
|Mercy Hospital
|St. Louis, Missouri, United States, 63141
|United States, New Hampshire
|Dartmouth Hitchcock Medical Ctr
|Lebanon, New Hampshire, United States, 03756
|United States, New Jersey
|Cooper University Hospital
|Camden, New Jersey, United States, 08103
|Holy Name Medical Center
|Teaneck, New Jersey, United States, 07666
|United States, New York
|North Shore-Long Island Jewish
|Lake Success, New York, United States, 11042
|St. Luke's Roosevelt
|New York, New York, United States, 10025
|United States, North Carolina
|University of North Carolina at Chapel Hill
|Chapel Hill, North Carolina, United States, 27599
|Wake Forest Baptist Health
|Winston-Salem, North Carolina, United States, 27157
|United States, Ohio
|University of Cincinnati
|Cincinnati, Ohio, United States, 45267
|Regional Infectious Disease and Infusion Ctr
|Lima, Ohio, United States, 45801
|United States, Oklahoma
|University of Oklahoma
|Tulsa, Oklahoma, United States, 74135
|United States, Oregon
|Oregon Health Science University
|Portland, Oregon, United States, 97239
|United States, Rhode Island
|Rhode Island Hospital
|Providence, Rhode Island, United States, 02903
|United States, South Carolina
|Roper St Francis Medical Center
|Charleston, South Carolina, United States, 29401
|Greenville Health System
|Greenville, South Carolina, United States, 29615
|United States, Tennessee
|University of Tennessee
|Knoxville, Tennessee, United States, 37920
|United States, Texas
|Baylor Medical Ctr
|Dallas, Texas, United States, 75226
|University of Texas - Houston Medical School
|Houston, Texas, United States, 77030
|United States, Washington
|Peace Health Southwest Medical Center
|Vancouver, Washington, United States, 98682
|United States, West Virginia
|Charleston Area Medical Center Institute
|Charleston, West Virginia, United States, 25304
|Principal Investigator:
|Mark Iafrati, MD
|Tufts Medical Ctr
|Responsible Party:
|Harvest Technologies
|ClinicalTrials.gov Identifier:
|NCT01245335 History of Changes
|Other Study ID Numbers:
|First Posted:
|November 22, 2010 Key Record Dates
|Last Update Posted:
|December 15, 2015
|Last Verified:
|December 2015
Critical Limb Ischemia
Peripheral Arterial Disease
Stem Cells
Limb amputation
Leg ulcers
Peripheral Arterial Disease
Pathologic Processes
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Peripheral Vascular Diseases