text:
Mechanism found for destruction of key allergy-inducing complexes, researchers say
Ted Jardetzky
Researchers have learned how a man-made molecule destroys complexes that induce allergic responses — a discovery that could lead to the development of highly potent, rapidly acting interventions for a host of acute allergic reactions.
The study, published online Oct. 28 in Nature, was led by scientists at the Stanford University School of Medicine and the University of Bern, Switzerland.
The new inhibitor disarms IgE antibodies, pivotal players in acute allergies, by detaching the antibody from its partner in crime, a molecule called FcR. (Other mechanisms lead to slower-developing allergic reactions.)
"It would be an incredible intervention if you could rapidly disconnect IgE antibodies in the midst of an acute allergic response," said Ted Jardetzky, PhD, professor of structural biology and senior investigator for the study. It turns out the inhibitor used by the team does just that.
A myriad of allergens, ranging from ragweed pollen to bee venom to peanuts, can set off IgE antibodies, resulting in allergic reactions within seconds. The new inhibitor destroys the complex that tethers IgE to the cells responsible for the reaction, called mast cells. Severing this connection would be the holy grail of IgE-targeted allergy treatment.
The first time a potential allergen enters the body, some people respond by making allergen-specific IgE antibodies. These antibodies stick around long after the initial allergen is cleared from the body. Most of the antibodies get snagged by IgE-specific receptors called FcRs, which are exposed on the surface of mast cells. The mast cells are then primed to react the next time a person encounters the allergen.
Dissociation of this IgE-FcR interaction is a sought-after goal of allergy treatment for a good reason: IgE-coated mast cells are grenades of histamine, and re-encountering the allergen is equivalent to pulling out the clip. When an allergen makes a return visit, it binds to the pre-loaded IgE on the mast cell surface, triggering the release of inflammatory mediators — including histamine — that promote the allergic response. As allergy sufferers are well aware, these nasty reactions can occur within a matter of seconds. In a severe allergic response, sudden anaphylactic shock and death can be the result.
The key to actively disabling the allergic response lies in the separation of IgE from the FcRs on the surface of mast cells. But separating these dangerous couples is a tall order because their interaction is extremely stable — sensitizing the mast cells for weeks. Currently available treatment using omalizumab (an anti-IgE antibody sold under the trade name Xolair) can block new interactions between IgE and FcR, but it is not designed to pry the molecules apart once they've formed a bond on the surface of a mast cell. So Xolair can dampen the allergic response, but as stated on the product's website: "Xolair is not a rescue medicine and should not be used to treat sudden asthma attacks."
While simply blocking IgE binding is helpful for some allergy sufferers, when it comes to the rapid quenching of an acute allergic response, "what you'd really like to do is get rid of it," said Jardetzky. Along with scientists at the University of Bern, his team discovered that an engineered protein inhibitor called DARPin E2-79 stripped IgE from the mast cell receptor. Using this inhibitor, "an interaction that normally lasts for hours or days in terms of its stability is stripped off in a matter of seconds," said Jardetzky.
DARPin E2-79 is one of a family of engineered inhibitors containing protein-binding regions called ankryin repeats. While Jardetzky's group was using structural biology and biophysical approaches to probe the weak spots in the IgE-FcR interaction, scientists at the University of Bern were tinkering with DARPins that dampened IgE's disastrous effects. The collaboration of the two groups resulted in the characterization of DARPin E2-79, an inhibitor that goes beyond mere blockade to actively disassemble the IgE-FcR power couple.
Jardetzky's group solved E2-79'S structure and used this information to model its interaction with the IgE-FcR pair. Then, using sensitive biochemical techniques that detect step-by-step binding interactions between molecules, the teams were able to tease out the mechanism that the inhibitor uses to break the IgE-FcR bond.
The researchers found that E2-79 hastens the separation of the two molecules by taking advantage of a moment of weakness in the relationship between IgE and FcR. IgE maintains its interaction with FcR using two contact points, and occasionally one of these points releases while the other one keeps the pair together. Normally this brief looseness isn't enough to separate the couple, but E2-79 can swoop into the small space between them, effectively driving the couple apart.
While E2-79 is the first molecule to display these IgE stripping characteristics, Jardetzky hopes that this work will stimulate the discovery of smaller compounds capable of working even more efficiently. Drug developers generally expect large macromolecules like E2-79 to be less potent than small molecule inhibitors and unlikely to be able to disrupt complexes, so the fact that E2-79 worked so well was a surprise. Small molecules are more amenable to oral administration, and are easier and cheaper to manufacture than large macromolecules. "Now we're in the hunt for a small molecule that could have this kind of activity. That would be the real hit," said Jardetzky.
The discovery of E2-79's mechanism of IgE inhibition could lead to rapid discoveries from other labs as well. Now that scientists know what mechanism to look for, they may be inspired to dig back through freezers full of IgE inhibitors that were identified years ago, said Jardetzky. In the light of techniques described in this study, perhaps once-neglected inhibitors will show new promise in the treatment of allergic disease.
The study's primary authorship was shared between Beomkyu Kim, PhD, a Stanford graduate student, and Alexander Eggel, PhD, at the University of Bern. The other Stanford co-author is research assistant Svetlana Tarchevskaya.
The study was funded by the National Institutes of Health, the American Asthma Foundation and the Swiss National Science Foundation. Information about Stanford's Department of Structural Biology, which also supported the work, is available at http://structuralbio.stanford.edu/.
Jessica Shugart is a science-writing intern for the medical school's Office of Communication & Public Affairs.
Stanford Medicine integrates research, medical education and health care at its three institutions - Stanford University School of Medicine, Stanford Health Care (formerly Stanford Hospital & Clinics), and Lucile Packard Children's Hospital Stanford. For more information, please visit the Office of Communication & Public Affairs site at http://mednews.stanford.edu.


text:
Region: Great Lakes
Latest Edition: 19 Ed. (1-Feb-2016)
Last Correction: 1-Aug-2019
Cleared Through: NTM 47/2019 (23-Nov-2019)
Paper Size: 50" x 36"
Chart Image Size: 34" x 46"
Scale: 1:40,000
Captain's Nautical Supplies is a Print-on-Demand nautical chart dealer for US Waters. All charts are printed up-to-date and corrected to the latest Notice to Mariners and meet commercial carriage requirements. Charts are printed on high-quality heavy paper with waterproof ink unless otherwise selected.
Tags: Approach (1:20001 – 1:50000), Great Lakes, Lake Superior
Product Type: Paper Chart
Vendor: National Oceanic and Atmospheric Administration (NOAA)
Product #: NOAA-14976
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subset: commoncrawl


text:
National Pump & Energy (NPE) is a specialist Cairns equipment hire and dewatering company.
Our Cairns equipment hire facility supplies a range of equipment for rent including:
- Lighting tower hire
- Pump hire
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- Water Pumps
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- Electric Submersible Pumps
- Hydraulic Submersible Pumps
- Flood Pumps
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- Pump Hoses
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- 6kVa – 1250Kva generators for hire
- Hire Equipment available in various configurations including trailer mounted, skid mounted, silenced, diesel, electric and more
We service all local industries in Cairns and North/Central Queensland for pump, generator, compressor and plant hire.
The industries in Cairns that we service for hire and sale of specialised equipment for long or short term hire include:
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NPE is an experienced dewatering contractor and offers dewatering services in Cairns and North/Central Queensland. This includes:
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- Underground dewatering
- Groundwater dewatering
- Wellpoint dewatering


text:
Looks like you are using an old version of Internet Explorer - Please update your browser
This paper focuses on the clause Job 40:17a, which is crucial to the proposition that Behemoth could have been a type of dinosaur.
The changes that have occurred in the Indo-European language family, for example, demonstrate that languages follow a 'downhill' simplification in inflections, etc. by natural processes.
However, Pennock frequently ridicules the Bible and is generally contemptuous when referring to creationists.
No results found in .
Answers in Genesis is an apologetics ministry, dedicated to helping Christians defend their faith and proclaim the gospel of Jesus Christ.


text:
So, we've seen tributes to Star Wars, Blade Runner (actually, a carry-over of a Fallout and Fallout 2 reference to that movie) and we know there's one for Indiana Jones in Fallout: New Vegas. That's three. There must be more.
Reader Paige B. just sent that in; the "Rodent of Unusual Size" is a nod to "The Princess Bride." Spot on!
Just for the record, here's the fedora-in-a-fridge, well early in the game, supplied by reader TheTingler. Many of you have seen and mentioned this. It makes fun of the infamous and implausible scene in Indiana Jones and the Kingdom of the Crystal Skull, in which
Han Solo Jack Ryan President James Marshall Calista Flockhart's husband survives a nukeular blast by hiding in the Norge.
As we're about a week into release, we should be seeing many, if not most, of these kinds of homages in New Vegas. Post them here, screenshots if you can dig 'em up, or just gab about any other ironic or darkly humorous detail that tweaks your funnybone in the latest Fallout installment.


text:
SONY MEDIA SOFTWARE Acid Pro 5 (Win)
Whenever a major corporation acquires a music software company, there's always some uncertainty about what the future holds. When EM reviewed Acid Pro 4.0 in its June 2003 issue (available online at www.emusician.com), the program was still under the aegis of Sonic Foundry. Today, however, Acid is a Sony product. It is a special pleasure to report that Sony has taken Acid's development seriously. Acid Pro 5 boasts several vital new features that should keep it competitive in the hurly-burly of desktop music production.
For starters, Acid can now function as either a ReWire host or a ReWire client, which allows it to integrate fairly seamlessly with a number of important DAW programs on the PC. Acid can now quantize MIDI and audio to grooves in a flexible and intuitive fashion. The Track view has been cleaned up by the addition of folder tracks (see Fig. 1), and the new Media Manager database utility will be a godsend to any Acid user who has a large loop library.
Acid is primarily a multitrack production tool, and therefore it makes no attempt to compete with the real-time interactive capabilities of programs such as Ableton Live. It has some important features, though, such as support for video and surround mixing, that Live lacks. In this review, I'll focus on the new features in Acid Pro 5. But first I'll start with a quick survey of the program's basic functionality.
The Acid Base
Acid's raison d'etre is to allow audio loops to be time-stretched and pitch-shifted seamlessly. Throw a bunch of loops into the program, paint them into the tracks where you want them to play, and you can achieve a professional-sounding mix with the greatest of ease, provided you have the right loops on your hard drive. If Acid doesn't change the tempo of a beat or other audio clip with the kind of transparency or precision that you need, you can open the Track Properties window and drag the slice points around on the waveform, auditioning the results at the current tempo of the project until it sounds good.
The track-editing commands are comprehensive. When dragging-and-dropping audio clips, you have the option of making them snap to a grid. Tempo changes can be programmed, and you can pitch-shift different instances of a sample separately in order to follow a chord progression. Five types of timeline markers are supported. As an alternative to using track automation, you can fade in at the beginning of an audio clip and fade out at the end.
Track parameters can be automated with graphic point-and-click envelopes (though not by recording control moves in real time with the mouse). The same technique applies to plug-in effects' parameters, if the plug-in allows it. A built-in suite of effects gives you plenty of control over sonic details, and Acid's VST support opens up a world of other options. I tried Antares Filter and iZotope Trash — two of my favorite plug-ins — and got good results. My computer had two freeze problems, however, when opening the Edit window for Filter. Sony reports that it has duplicated the problem — which is intermittent — and is working with Antares on a fix. I also had two crashes while Acid was running as a ReWire slave under Cubase SX 3. Sony has not seen any other reports of that problem, but the company indicates that version 5a, which should be available for download by the time you read this review, contains several ReWire fixes.
Although most programs that host plug-ins have a CPU usage meter, Acid is not one of them. Nor will Acid freeze tracks that use synth or FX plug-ins in order to free up CPU horsepower — another feature found in most DAW software. It is true that you can render a track and then unload the plug-in, but that takes several extra steps. What's more, Acid will destroy any automation envelopes when an effect is unloaded, which will be a big headache if you should need to reedit the effect automation later.
Acid's Chopper window provides a quick way to make new beats out of old ones or do buzzing 64th-note fills. Regions within a loop can be selected and inserted in the track using key commands, a much faster method than dragging segments around in the track window itself. Using the Chopper is definitely fun!
MIDI Miasma
Starting with version 4, Acid added MIDI tracks, which can be used with either external hardware synths or VSTi soft synths. Though they are functional and are certainly an important addition to the program, Acid's MIDI implementation is inferior to what you'll find even in an entry-level sequencer. The conceptual logjam, which Sony has failed to come to grips with in the version 5 release, arises from the fact that Acid allows you to assign only one media clip to any given track. Although that might make sense for audio tracks (albeit Acid is the only program that I know of with this limitation), it doesn't make any sense for MIDI tracks.
Several undesirable results stem from that design choice. For instance, the piano-roll editor window doesn't scroll during song playback, and its time ruler always starts with bar 1, beat 1, no matter where in the song the MIDI clip is positioned. What's worse, while you can record a new MIDI phrase just the way you would in a real MIDI sequencer, once the phrase has been recorded, you can't overdub or punch-in on it. Flubbed notes can be fixed in the piano-roll or event-list window, but if you need to erase a particular lick within a MIDI track and rerecord it, your new recording will go onto a different track. Copying and pasting will then be required to get the two MIDI licks into the same track.
In version 5, MIDI Control Change contours can be edited graphically in the piano-roll window using a familiar controller strip. Unfortunately, the selection and eraser tools don't work in the strip: whenever the mouse cursor is over the strip, it turns into the paintbrush tool. As a result, if you should want to overdub a MIDI part that includes Control Change or Pitch Bend data, cutting-and-pasting can't be used to get the data into a single track, because those data types can't be selected for copying. They can be selected for deleting in the event list, but the Copy command doesn't work there.
While using Native Instruments Absynth 2 as a plug-in synth in Acid, I found that Absynth played the correct patch when I loaded the file but sometimes subsequently switched back to patch 1. That happened several times.
Managing Media
Acid's new Media Manager will be a terrific boon for those people who have a collection of loop libraries on their hard drive (see Fig. 2). Media Manager creates a searchable database of all the loops in whichever folders you choose. Initially, the database will show only the information in the file name and any tags that the library developer thought to include in the file header, which means, for instance, that you could see a list of dozens of files all named "drums02." You would then have to scroll over to the column containing the full directory path information to figure out what you're hearing.
You can add existing tags or your own comments to any item, which will then be included in the search process. Compilation and searching of the database are fast, and you can organize the database window to show the items with which you are most concerned. Note that the Media Manager is in addition to, and not a substitute for, a conventional browser. That is good, because you can still use the browser to find files that are on uncataloged CDs, for example. (Sony claims that all new Acid libraries are now catalogued.)
The new Groove Pool in Acid 5 offers a quick way to realign audio to fit any rhythmic feel (see Fig. 3). Just drag-and-drop a groove from the Groove Pool window onto a track, and notes within the audio file will shift forward or backward as needed to match the groove. Grooves can be extracted from any existing loop and can be added to the Pool, provided that stretch markers already have been placed in the loop file. (If stretch markers haven't been placed, you can do that yourself.) You can also move groove markers to different spots to create your own grooves.
It's normal for sampled loops to have slightly different placements of different beats, and Acid gives you a quick way to line up the beats so that they lock together. Grooves can be applied to different portions of a single sample, and grooves can be applied to MIDI data in exactly the same way.
In my experiments, applying grooves to audio clips didn't always sound good. Even when a beat is playing back at its original sampled tempo, laying a new groove on it sometimes produces audible time-stretch artifacts. It's best to use grooves selectively; for instance, in a beat with an 8th-note feel and just a few 16th notes, I added the "16th Note Swing" groove only to the spots where there were 16th notes. That changed the feel of the 16ths without blurring the other drum hits. You can find an example of this editing technique on the EM Web site (see Web Clip 1).
More New Stuff
Among my favorite new features in Acid are folder tracks. After creating a folder track, you can tuck any number of other tracks into it and open or close the folder. That eliminates a lot of clutter in the Track window. If your project uses a dozen different drum loops, for instance, you can put them in a folder track, name it Drum Loops, and close the folder so that the dozen tracks are displayed as only a single narrow strip. Folder tracks can be muted or soloed but have no other track parameters. (A global output-level fader for each folder track would be a nice addition to the program.)
Speaking of track muting, I'm still waiting for another problem in Acid to be fixed: the Track Mute buttons override the track's volume fader, but a track's output can be sent to a bus either prefader or postfader. If a prefader send is being used as a track output, the Mute button doesn't shut off the sound of the track. (Sony claims that design choice was intentional, and it is not viewed as an oversight in need of fixing.)
Multimedia developers will be pleased that Acid lets them add interactivity to a presentation streamed over the Internet. At a particular spot in the music, for instance, you can open up a new Web page. Text (even closed-captioning) can be added, as well as clickable links. And speaking of media, Acid will now perform disc-at-once CD burning.
You can extensively customize Acid's keyboard command set to match the way you like to work. The toolbar at the top of the Main window can also be customized. Most of the other enhancements in version 5 are minor: a metronome for playback and recording, the ability to reverse playback of a given audio clip without stopping the transport, support for VSTi soft synths that require multiple mixer channels, and mixer routing from one effects bus to another, rather than from only each bus to the master bus. There's also support for Macromedia Flash SWF file import, the ability to adjust the levels of several clips within a track with a single mouse move, and more. The metronome lacks precount for recording, but at least you can control its loudness. I tested the VSTi support by instantiating Native Instruments Battery 2, whose 16 stereo outputs make it a real mixer hog, and Acid had no trouble coping.
The Acid Test
The new features in Acid Pro 5 make the program a pleasure to work with. ReWire support largely overcomes the significant limitations of Acid's MIDI tracks, at least for anyone who owns a ReWire-capable sequencer. ReWire also makes it easy to use Acid in tandem with Reason for deep-groove productions. The Groove Pool and Media Manager are excellent additions, and the folder tracks, while a seemingly humble detail, eliminate screen clutter, which makes a big difference in handling the workflow. My biggest reservation about Acid is that it won't freeze CPU-hogging tracks. Overall, I'd put Acid in the "good but not great" category. It isn't the lightning bolt that it was six years ago, but it's still a respectable piece of software and will continue to have a worthy place in many desktop music environments.
Jim Aikin writes, plays, and teaches in Northern California. His latest book is Chords & Harmony, an introduction to music theory. For more information, visit him online atwww.musicwords.net.
Acid Pro 5
loop sequencer
$399 retail; $299.96 direct download
PROS: Video and surround-mixing support. New database and groove-editing functions. ReWire (host and client).
CONS: MIDI track handling has not been improved. No CPU usage meter. No track freeze.
Sony Media Software


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text:
Recovery centers open in NE Minnesota
Disaster recovery centers are opening up in northern Minnesota today, in the wake of last month's storms and flooding.
The centers are being run by the Homeland Security and Emergency Management division of the state's Department of Public Safety. They will bring together state and local government agencies that will have information and resources for residents and business owners who suffered damage during the flooding.
State services include the Minnesota Housing Finance Agency, the Attorney General's office, the departments of health and human services and the department of employment and economic development.
The services will be available in three locations, starting this afternoon. They include the Duluth Entertainment and Convention Center, the Barnum High School and the Willow River School. All three will be open from 1 to 7 p.m. today, and from 9 a.m. to 3 p.m. through Monday.
State officials say they'll have someone to meet with anyone who needs assistance as a result of the flooding.
N.E. Minnesota Flooods
• 'This is what global warming looks like'
• Jay Cooke State Park closed indefinitely
• Grappling with private property damage
• Climate change and Duluth's rebuilding plans
• Road repairs could takes to complete
• Photos: Duluth, northeast Minnesota awash
• Photos: Gooseberry Falls at full trottle
• Photos: The wake of the flood
• Photos: Sandbagging in Moose Lake


text:
Welcome to the Future of State Universities Conference
Held in Dallas, Texas in October of 2011.
The conference brought together thought leaders from across America and around the world, leadership of public universities, state governors and other policy makers to discuss the emergence of new models that can help public universities flourish in the future.
Speakers addressed, with insight and directness, the core components that are changing the most from historic norms: tuition and sources of revenue, instructional delivery and the role of a professor, students' expectations and access, college readiness, regulatory environment and internationalization. Courses of action were considered that will enable public universities to succeed in a new reality.


text:
|For other characters in the Fallout universe named Henry, see Henry (disambiguation).
Doctor Henry is a former Enclave scientist living in NCR in 2241 and in Jacobstown in 2281.
New CaliforniaEdit
Doctor Henry was a pudgy guy with a shiny bald head and thick-lensed glasses.[1] He used to work with the Enclave cyber-genetic research program at the Poseidon oil rig and at various other Enclave installations. In NCR, Dr. Henry claims he left because he felt his "work wasn't being appreciated," which is true: his theories on correcting the mutation in the Wasteland population were not popular with the rest of the Enclave scientists, most notably one of his colleagues, Dr. Schreber, who he worked with jointly on many genetic research projects in the past.
Dr. Henry was arguing with Schreber at the Navarro base about the mutation problem for the five billionth time when Schreber, in a fit of anger, told Henry he was going to recommend that Henry be transferred to another Enclave facility where he would be put to work on cybernetic maintenance (the equivalent of cybernetic janitorial duty). Henry took the threat very seriously, and within hours, Dr. Henry stole a cybernetic dog (cyberdog) and slipped away from the Navarro facility, heading east and eventually making his way to NCR. The Enclave, while not pleased with his attitude and the directions of his research, were not happy with his escape (they need all the scientists they can get), and several soldiers were punished for negligence. Schreber never confessed to his role in Henry's disappearance, and simply claimed that Dr. Henry had been acting suspicious for some time, and was displaying "sympathies for the mainland mutants."[2]
After deserting the Enclave base at Navarro, Henry successfully integrated into the NCR and runs a clinic in New California Republic. This clinic, in which he is perpetually busy, can be found directly to the south of Duppo's shop, but it is unmarked. His reason for this departure is unclear, but he hints that it was due to his "single-minded colleagues" only striving for purification. His field of expertise is cyber-genetics and he is attempting to translate this knowledge into an experimental treatment or cure for FEV mutations. The local crime lord, Merk, took an interest in his research and will hire the Chosen One to obtain his research papers.
K-9 was left in NCR by the Chosen One so that he could receive necessary repairs from Dorothy and, not long after his recovery, Dr. Henry (who had been placed in critical condition after being reportedly assaulted by the Chosen One some time earlier). Dr. Henry, afraid that too much information about the Enclave would be obtained from K-9, attempted to destroy the cyborg, but was stopped by cyberdog and Dorothy, who suspected what Dr. Henry was planning. The NCR government used the attack as an excuse to confiscate K-9 and cyberdog in order to learn more information about the Enclave as well as what makes the two of them "tick." At last report (and over Dorothy's objections), K-9 and cyberdog were disassembled and analyzed. Structural damage during the disassembling is reported to have killed them both.[2]
Sometime after the NCR captured Navarro, he met his old squadmates, Daisy Whitman, and young Arcade Gannon along with his mother. After the NCR began hunting Enclave personnel who were attempting to integrate themselves into the NCR, they left for the Mojave Wasteland.
Mojave WastelandEdit
Dr. Henry appears in Fallout: New Vegas at Jacobstown, where he is attempting to find a cure to the nightkins' schizophrenia, brought on by prolonged Stealth Boy use. Should the Courier decide to assist in his research with night stalkers and the Stealth Boy Mark II, he finds the cure for the nightkin. Dr. Henry is also a part of the quest Nothin' But a Hound Dog where he performs surgery to replace the brain of Rex.
In his youth, he traveled to the Mojave Wasteland on a caravan with the youth Old Lady Gibson where they got to know each other intimately.[3] But that was just a fling, and once they reached their destination, they parted ways.
Interactions with the player characterEdit
Fallout 2Edit
Interactions overviewEdit
|This character starts quests.
|This character is allied with the following faction(s).
- Test mutagenic serum on a super-mutant. Try Broken Hills: Asking Henry about cyber-genetics gives a mission to test a prototype serum on a super mutant.
Fallout: New VegasEdit
Interactions overviewEdit
|This character is a doctor.
|This character starts quests.
|This character is involved in quests.
- Guess Who I Saw Today: Henry will ask the Courier to go up to Charleston Cave and retrieve a Stealth Boy. Following that, he will ask they bring Lily Bowen into his office so he can run a couple of tests on her.
- For Auld Lang Syne: Dr. Henry is one of the Enclave remnants the Courier is tasked to find.
- Nothin' But a Hound Dog: Dr. Henry is the only one in the Mojave Wasteland that is skilled enough to transplant a new brain into Rex.
Effects of player's actionsEdit
- After For Auld Lang Syne is complete, he and the squad will assist the Courier at the Second Battle of Hoover Dam.
Fallout 2Edit
|Other items
|Doctor outfit
Fallout: New VegasEdit
- The Chosen One cannot be healed at Henry's clinic in NCR, as it is more of a research lab. The Chosen One can heal at the hospital, run by Doc Jubilee.
- As discovered in dialogue, Henry knew about the Vault Behavioral Project.
- Unlike all others with the title of Doctor in Fallout 2, he cannot heal the Chosen One.
- Despite the fact that ex-Enclave personnel (and even the children there-of) are hunted by the NCR and many others for war crimes, Doc Henry will freely mention he was a member of the Enclave while speaking to the Courier in his lab at Jacobstown (even before the start of the quest For Auld Lang Syne). As such, he is the only remnant to do so.
- If Calamity is dead, he will still "hand over control of the lab to her."
- Henry's word for the remnants bunker is "Friends."
- He will not turn hostile when attacked.
Notable quotesEdit
- "This guy is so out of place it's painful. He's got that egghead, not living in the real world air about him, that's for sure." – Fallout 2 in-game description
- "Doc Henry was always a hard one to figure out. It didn't seem to matter whether he was working with humans or dogs. He had an equal lack of affection for both; a regular Diogenes. I'm not sure what the man was after." – Arcade Gannon's opinion
- "Nice work with the Nightkin. I've never seen anyone able to talk their kind out of anything once they had their mind set to it."
- "I assume this is about something important? You're interrupting my research."
- "Because Marcus asked me to and because it's a reason for me to get up in the morning. I'd like to get one more grand accomplishment done."
- "That's... brilliant. Simple, yet elegant. I can't believe I didn't think of that."
Dr. Henry appears in Fallout 2 and Fallout: New Vegas.
- Xbox 360 Sometimes he will not perform medical services for the player. [verified]
- PC Sometimes he may just say, "Keep your head down - there could be snipers around." This makes any communication with him impossible. There is no known fix for this bug, however it may work to disable, enable, kill and resurrect him using console commands. [verified]
- Playstation 3 Xbox 360 Starting Nothin' But a Hound Dog after completing For Auld Lang Syne instead of before will cause him to reappear in Jacobstown. [verified]
- This will also result in there being two Henry(s) in the Second Battle of Hoover Dam, one with wasteland doctor fatigues, and one with an Enclave scientist outfit. [verified]
- ↑ Schenry.msg , line 100
- ↑ 2.0 2.1 Fallout Bible 6
- ↑ The Courier: "How did you meet Doctor Henry?"
Gibson: "He and I had joined up with the same caravan. Add in a lot of whiskey, and, well, let's just say we got to know each other."
(Old Lady Gibson's dialogue)


text:
River Kwai Resort was only recently completed on a giant 250 Rai
(or 64.000 m2 / 40 Hectares / 16 Acers) plot in a mostly untouched part
of Kanchanaburi Province. Although the Nakakiri Resort & Spa Kanchanaburi
is fully equipped & capable to handle large groups of guests for seminars,
mini conferences and company get-away's, it's only in the central part
of the resort where the huge swimming pool, the restaurant and lobby
building and the most comfortable of our accommodations: the Villa's
are, where you will see activity during the week. The wooden floating
raft houses with their very fine bed- and bathrooms are traditionally
most popular with both our Thai guests as well as the international
explorers of Thailand that tend to spend only 1 or 2 nights in Kanchanaburi
and come to really connect with nature, while the two storey Kiri Village
buildings see a lot of single or dual day organized tour visitors that
want to get away from all the tourism and noise in Kanchanaburi city
or make just a short trip from Bangkok, Hua Hin or even Pattaya.
|River kwai raft rooms and the beautiful Poolside and River View villa's in the Nakakiri Resort & Spa in Kanchanaburi, Thailand.
20 Floating House (Raft)
The most "authentic" of all types of accommodations in the Nakakiri Resort & Spa. These typical Kanchanaburi style floating raft houses will really make you feel closer to the River Kwai and the impressive jungle on the opposite side of this famous river. You will love noticing the differences in flow speed, but you will want to stay there forever because of the breathtaking views in the early mornings, when a light fog slowly surrenders to rising sun. We highly recommend these river raft houses to those that are traveling around Thailand and want to experience as much different locations and surroundings as possible; to groups that prefer to have their own little place away from the other guests and to those that just find more joy in being close to (true) nature, rather than the luxuries of having a swimming pool side villa.
42 Superior River View
The most affordable and easy to reach accommodations in our River Kwai Resort. These Kiri village rooms are often indicated as standard rooms, yet they can easily compete with any type of superior or deluxe room in most other resorts in Kanchanaburi. Even though these are two floor buildings, the rooms have high ceilings and they are soundproofed. Of course, these excellent rooms offer not only all of the comforts and luxuries as listed above, most of them also provide a excellent view of the river kwai and our gardens next to it. Those that bring their own car will be pleased that many of the Kiri Village Hotel rooms offer the possibility to park in front, or actually behind those hotel rooms. Definitely not as close as you could in a motel, but the car will be certainly be near enough to check on, or hear if there is an alarm going off. Not that that will happen anytime soon, thanks to the somewhat remote location of the resort, but more so due to the fact that we have security guards on duty 24 hours / day and their booth is less than 50 meters away from the Kiri Village rooms.
32 Villa River View & 6 Villa Pool View
Our top accommodations for our most privacy and comfort loving customers. Enjoy the excellent river Kwai & jungle views or enjoy the easy of walking only a few steps from your own terrace, straight into the giant swimming pool. Get 2 adjoining villas when traveling with family or another couple and meet up for drinks & snacks in the lovely little seating area between the twin villas. Inside the villas in the Nakakiri River Kwai Resort you will find the biggest bathrooms you have seen in a while with a big bath, hot water shower, huge make up table and lots of closet space. Next to the bathroom you will find a small unit with a double kitchen sink where you can prepare drinks or a snacks without worrying about getting the bathroom dirty. The two "glass walls" in the villas all come with lightproof dual layer curtains, so feel free to sleep as much and as long as you'd like, but remember that our breakfast buffet closes at 10:00.
|Villa River View
|Villa River View
|Villa River View
|Villa Pool View
|Villa Pool View
|Villa Pool View
|Trip & Activities
nearby :
|Swimming Pool
|Swimming Pool
|Swimming Pool
|Meeting Room
|Golf cart
|Nearby Hindad Hot Spring


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Wonderful Wall Coverings
Some have beautiful murals, some have bold graphics, and others add subtle shimmer. We're talking about wall coverings.
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Click through to see how these gorgeous patterns can accentuate any space.
Here, Schumacher paper on the walls in black Monaco Damask creates a graphic first impression in the entry.
Interior Design: Tobi Fairley
Plump Pineapple
Large-scale pineapples on the entry hall's Studio Printworks wallpaper are almost as tall as six-year-old Prentiss.
Interior Design: Katie Brown
Perfectly Pink
Crisscross- and trellis-patterned fabric and wallpaper, both from China Seas, envelop the master bedroom in soft pink.
Interior Design: Dee Elms and Andrew Terrat
Great Outdoors
A hand-blocked Zuber wall covering depicting a French landscape enhances the breakfast room's connection to the outdoors.
Interior Design: Timothy Corrigan
Salmon & Seaweed
Designer Katie Ridder's "Seaweed" wallpaper in lavender is featured in the butler's pantry of the Hampton Designer Showhouse.
Interior Design: Kate Ridder
Buttery Yellow
"It all started with the wallpaper," says designer Keith Carroll. "When I saw it, I was intrigued. It looked very traditional but upon closer look was quite out there!" The Scalamandré "Chien de Pompeii" wallpaper in buttercream adorns what Carroll calls "the bedroom of world travelers with great taste."
Interior Design: Keith Carroll
Malchalite Mood
At the 2012 Holiday House Designer Showcase, "Malchalite" wallpaper from Fornasetti for Cole & Son draws the eye in Lee W. Robinson's Chinese New Year room.
Interior Design: Lee Robinson
Floral Forest
Wrapped in a hand-blocked linen fabric with red flowers, the guest bedroom features a French Suite that includes a settee and matching chairs. The paper-backed fabric is a Jim Thrope antique hand-print.
Interior Design: Jack Fhillips
Artsy & Ethereal
Walls in this artist's studio are covered in a kaleidoscopic Idarica Gazzoni wallpaper that somehow manages to be simultaneously dramatic and ethereal.
Interior Design: Joe Lucas and Parrish Chilcoat
Glorious Green
A floral paper in green and metallic gold directs the palette in this bedroom. The Brewster paper is from designer Jack Pole's unique wallpaper boutique, wallpaperyourworld.com, which offers timeless designs in a sustainable format.
Interior Design: Jack Pole
Pop of Pink
A wall of "Mardale" red floral wallpaper by Cowtan & Tout enlivens the otherwise neutral master bath.
Interior Design: Dee Elms and Andrew Terrat
Elegant in Emerald
The mouthwatering hues of an emerald green de Gournay wallpaper lend themselves to unpredictable pairings like daring orange, a color drawn from the silk background.
Interior Design: Melissa Warner
Traditional Toast
"Woolverston Toast" wallpaper by Cole & Son is a gorgeous traditional print in a neutral hue.
Dainty Details
Blue-and-white Osborne & Little chinoiserie wallpaper with a metallic sheen dresses up a tiny guest bedroom.
Interior Design: Julie Massucco Kleiner
Pump it Up
Striped wallpaper by Dedar in creamy ivory and gold pumps up the walls in the dining room. Turquoise backs on the dining chairs provide a dramatic contrast.
Interior Design: Megan Perry Yorgancioglu
Flora & Fauna
Hand-painted wallpaper from Fromental in a delightful green is eye-catching in the entry.
Interior Design: Samantha Todhunter
Vintage Vibes
Ivory and gold "Madrid" wall covering by Scalamandré and a chandelier from Century Lighting give the master bedroom a vintage feel.
Interior Design: Martin Horner
Cute Creatures
"When I saw the Lulu DK embroidered animal print, I knew I had to cover the walls with that," says interior designer Carla Lane. The playful fabric became the springboard for this blue-and-green nursery.
Interior Design: Carla Lane
Candy Crush
Fanciful "Tamara" wallpaper from Osborne and Little coordinates perfectly with myriad jars of similarly colored candies.
Gray Scale
Art Nouveau-style wallpaper from Cole & Son in the master bedroom complements a vintage Eames chair.
Blue Hues
Creating a subtle backdrop for the turquoise chest of drawers is "Vizir" wallpaper from Princes & Crows.
Retro Appeal
Lively wallpaper by China Seas wraps the room in a high-contrast cream-on-brown pattern with retro appeal.
Mighty Mural
Elegant scenic wallpaper from de Gournay is above the wainscoting. It honors the homeowner's old-world sensibility, but in a youthful, kicky palette of orange and pink.
Interior Design: Ruthie Sommers
Powerful Pattern
"Orchid" Cole & Son wallpaper covers just one wall in the den to avoid overpowering the small space.
Shimmery Setting
Dramatic, shimmery, hand-painted wallpaper from de Gournay is the star of this elegant dining room. Design tip: Make the most of a wallpaper's background. The light and airy base color plays up reflective accessories that enhance its luxurious shimmer.
Interior Design: Gerald Pomeroy
Serene Setting
In her room at the 2011 Holiday House Designer Showcase, Eileen Kathryn Boyd digitally printed a lavender watercolor for use as a serene and spellbinding wall covering. "Because the architecture is all squares and panels, I wanted to overlay it with something organic that had movement and flow," she explains.
Interior Design: Eileen Kathryn Boyd
Soothing Bedroom
A soft-blue tufted headboard from Mitchell Gold + Bob Williams set the tone for the master bedroom. Rose-patterned wallpaper designed by Ted Tyler is soothing in shades of muted gray.
Interior Design: Mariette Himes Gomez and Brooke Gomez
Corn Bred
Brunchswig & Fils' corn-motif wallpaper in the entry honors homeowner Kristi's Indiana roots.
Interior Design: Kristi M. Nelson
Punchy Paper
In the butler's pantry, patterned wallpaper from Meg Braff Designs packs a punch. "I liked the idea of something nautical and summery yet sophisticated," says Braff. "I love adding pattern to the walls when there is little other decorative interest in the room."
Interior Design: Meg Braff
Haute Herringone
The large dining room is all about high drama and fun. Using overscaled elements—a herringbone wallpaper by Idarica Gazzoni, a Swedish-style carved mirror, and a large antique dining table—sets a lively mood for parties.
Interior Design: Joe Lucas
Glamorous Gold
The bedroom's palette—gold, coral, and creamy white—creates a warm glow. "Auska" wallpaper from Osborne & Little is simply elegant.
Interior design: Melissa Warner
Crabby Cute
In the 2011 Hampton Designer Showhouse, Katie Ridder's whimsical yet modern "Crab" wallpaper lines the rear hall adjoining the kitchen.
Interior Design: Katie Ridder
Silver Scene
In the dining room, de Gournay custom wallpaper sets the scene, while an antique crystal chandelier and sconces add dazzle, with a simple sisal rug serving as a quiet backdrop.
Interior Design: Carrie Hayden
Moody Blues
A custom table, 1970s Lucite-and-brass bar stools, and Farrow & Ball "Silvergate" wallpaper create a glamorous corner in the billiards room.
Interior Design: Melanie Elston
Light & Lovely
A pretty and whimsical wall covering livens up the Swedish-inspired dining room.
Interior Design: Lillian August
Nice & Neutral
"Safran" print by Designer's Guild from Osborne & Little covers the walls in Sela Ward's light-filled work space.
Interior Design: Ann Runyon Carter
Garden Green
In this cheery sitting room, an Osborne & Little wallpaper is "a dizzy contemporary version of papers from the period between the wars in Britain," says designer Ellen Hamilton.
Interior Design: Ellen Hamilton
Simple Silver
To complement the "Charleston Damask" wallcovering by Ronald Redding and define the perimeter in style, painted white wood floors are bordered in silver-leaf stripes.
Interior Design: Gail Plechaty
Trellis Time
In the master bedroom, walls covered with Kelly Wearstler's trellis paper are complemented by Celerie Kemble's "Hot House Flowers" linen print on the headboard, pillows, chairs, and a bench.
Interior Design: Tobi Fairley
Zebra Zig-Zag
Wallpaper with leaping zebras, Scalamandré's signature print, and shimmering golden accents—mirror, fixtures, and lighting—jazz up the powder room.
Interior Design: Melissa Warner
Lovely & Ladylike
A floral wall covering provides texture, while yards upon yards of salmon silk taffeta from Scalamandré decorate the windows in this strictly feminine space.
Interior Design: Nancy Pearson
Clean Green
Clarence House wallpaper in green adorns the master bath's walls; a French antique stained glass window lights up the space.
Exuberant Blue
The dining room's exuberant wallpaper is from Cole & Son, while simple matchstick blinds relax formality.
Interior Design: Jeff Andrews
Pleasantly Pale
Of the Schumacher wallpaper chosen for the dining room, homeowner Sallie says it's "very pale and old-fashioned."
Whimsical Wallpaper
Along with its black marble sink surround and painted black-framed mirror, the handsome powder room features a whimsical tree-patterned wallpaper from Donghia.
Interior Design: Gail Plechaty
Easter Egg Turquoise
Turquoise velvet damask covers a fanciful chair, and a geometric Osborne & Little wallpaper patterns the walls in the Easter-themed room of the 2011 Holiday House Designer Showcase.
Interior Design: Jennifer Duneier


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The honorary Academy Award Steve Martin is set to pick up at Saturday's Governors Awards marks a recognition of his considerable contribution to movie comedy, which began nearly 35 years ago when "The Jerk" opti-grabbed audiences and shook them with laughter.
The lifetime achievement award also marks a recognition that Steve Martin probably will never win an Oscar. Which is a shame.
Oscar largely still doesn't get comedy. The scarcity of funny films to notch Oscar nods in recent decades spurred director/producer Judd Apatow ("Knocked up," "The 40-Year-Old Virgin") two years ago this month to call on the Academy of Motion Picture Arts and Sciences to create a Best Comedy category.
U.S. & World
Stories that affect your life across the U.S. and around the world.
One of Apatow's prized possessions is a letter he received as a kid from Martin, who, with fellow Oscar snub-ee Eddie Murphy (he lost for his dramatic turn in "Dreamgirls"), helped create the modern comedy box office hit, long before "Bridesmaids" and the "Hangover" flicks reaped as many dollars as laughs.
In Martin's case, it probably was too much to ask that laughers like "The Jerk" and "Dead Men Don't Wear Plaid" could compete with "Kramer vs. Kramer" and "Terms of Endearment." But "Roxanne," his 1987 take on "Cyrano de Bergerac," was award-worthy.
The slighting of Martin's out-of-body tour de force in "All of Me," one of the all-time great comedic big screen performances, still smarts. The 1984 effort, co-starring Lily Tomlin, harkened back to the screwball comedy era of the 1930s when the Academy Awards rewarded films like "It Happened One Night" and "You Can't Take it with You" with Best Picture trophies.
Recent years have seen a thawing of Oscar's icing out of comedies. Melissa McCarthy got nominated for Best Supporting Actress for splitting sides in 2011's "Bridesmaids." "The Artist," which won for the Best Picture of 2011, proved an often-funny tribute to the silent comedy era. Still, Woody Allen's 1977 bittersweet classic "Annie Hall" remains the last undisputed comedy to take home the big prize (we refuse to count "Shakespeare in Love" as a comedy).
Near the end of "The Jerk," Martin's down-on-his-luck Navin Johnson walks the streets carrying his few precious possessions – among them a chair, a remote control and a paddleball game. Come Saturday, the three-time Academy Awards host and zero-time nominee finally adds an Oscar to the pile at age 68, in a long-overdue salute to an actor and writer who has given all of himself to grateful audiences.
Hester is founding director of the award-winning, multi-media NYCity News Service at the City University of New York Graduate School of Journalism. He is also the author of "Raising a Beatle Baby: How John, Paul, George and Ringo Helped us Come Together as a Family." Follow him on Twitter.


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The American College of Obstetricians and Gynecologists (the College) is a membership organization dedicated to the advancement of women's health through education, advocacy, practice, and research. An important focus of our work is the development and recommendation of practice guidelines for the health care of women. Immunization against seasonal influenza (flu) and other vaccine-preventable diseases is an essential component of women's primary and preventive health care. Ob-gyns are an important source of information and advice on immunization for adult, adolescent, and pregnant women and play a crucial role in a pregnant woman's decision to get vaccinated against seasonal flu, protecting her health and the health of her unborn baby.
In 2005, ACOG called together a Task Force on Immunization (2005-2008) to strengthen the role of obstetrician-gynecologist in providing immunizations for adolescent and adult women. The members of this College Task Force, which met from 2005 until 2008 were Stanley A. Gall, MD, Chair, W. Paul Glezen, MD, Bernard Gonik, MD, Marc R. Laufer, MD, Gregory R. Moore, MD, Laura E. Riley, MD, and J. Martin Tucker, MD. Much of the material in this web site is based upon their thoughtful contributions.
In 2010, the College convened an Immunization Expert Work Group to further enhance the role of ob-gyns as vaccinators of adolescent and adult women. In 2017, the work group changed its name to the Immunization and Emerging Infections Expert Work Group, as they expanded their role beyond immunizations to address infectious diseases such as Anthrax, Ebola, and Zika virus. This Immunization and Emerging Infections Expert Work Group provides valuable contributions to this website. This Immunization and Emerging Infections Expert Work Group provides valuable contributions to this website.
The College has designed this website "Immunization for Women" to provide ob-gyns and their patients with a central, trusted source of up-to-date information on seasonal flu and other vaccine-preventable diseases, including immunization facts and safety, immunization schedules, clinical and practice management guidelines, and links to other reliable immunization resources. It is our goal to empower women with the knowledge they need to make informed decisions about immunization and their health and to provide ob-gyns with a valuable resource for immunization best practices and patient education.
If you are looking for an ob-gyn, please visit the ACOG Member Directory.


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Smelly Silk DHA Omega-3 soy milk?
I have no idea where to post this, so feel free to move it.
The only soy milk (or any kind of non-dairy milk) I like is the Silk DHA Omega-3 and have been drinking it for several years. However, the last two times I bought it when I opened it, it smelled like eggs or strong yeast or something. A few weeks ago, I'd bought two cartons at Wal-Mart and each had a mild eggy smell that dissipated rather quickly after opening so I drank them and didn't croak. About 1-1/2 weeks ago, I bought a three-pack of this Silk milk at Costco. I just opened one today (the expiration date is July something) and poured half a glass. When I took a drink, the smell of eggs or like sulfur assaulted my nostrils like a ton of bricks and I poured the glass down the drain. I RARELY throw any food/drink item out. I cut mold off of things and eat them if at all possible. This means the smell of this soy milk was very strong, almost like bad eggs. Now that it's been open a while, the smell is again dissipating.
These are from two different stores on different dates so I can't see it being one batch of Silk milk. I would like to return this three-pack but will not be going back to Costco for likely two months. Besides, as I said Wal-Mart also had smelly milk a few weeks ago, though not as bad.
Anyone else notice anything recently with the smell or anything else with Silk DHA Omega-3 soy milk? Anyone read anything about this? I found nothing doing a search.
Ohmigosh Yes! Just searched online to prove I'm not going crazy! Found out lately my Silk Unsweetened soy milk has been smelling like eggs too! I threw out coffee and cereal for a couple weeks before realizing by process of elimination that it wasn't the coffee, creamer, mugs, bowls, water, nor dishwashing liquid at fault. The soymilk was the only common denominator. Sniffed it, and bingo - eggy smell. Not rotten-smelling, but strong enough to be nauseating. Please call them - number is on the box. Hope they find out what's the trouble and correct it. Been buying this milk for at least a decade, and never heard of it happening before now.


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COLUMBUS -- Planned Parenthood and groups that oppose GOP-supported legislation limiting access to abortions voiced concern Tuesday that Statehouse Republicans would move forward with law changes during the final weeks of Ohio's general assembly.
And they're citing the results of the presidential election as evidence that voters aren't backing Republicans on abortion-related issues.
"We sent a clear, powerful and unmistakable message last week that women don't want politicians to meddle in their personal medical decisions," said Stephanie Kight, president and chief executive officer of Planned Parenthood Advocates of Ohio "It's clear some Ohio politicians didn't hear us last week, so we want to make sure that they can hear us now. ... Voters want to protect women's health care. They don't want to restrict it."
The press conference came a day before a legislative committee had scheduled a possible vote on a bill that would prioritize the distribution of funding for family planning services, a move that likely would block money for Planned Parenthood.
Additionally, the Ohio Senate is expected to take up the Heartbeat Bill, legislation that would block abortions within weeks of conception.
And Ohio Right to Life, the day after last week's general election, reiterated its positions on such issues.
"We refuse to relent simply because of the presidential outcome," Mike Gonidakis, the group's president, said in a released statement. "Ohio Right to Life looks forward to advancing our robust pro-life agenda we have crafted for 2013. As we look to grow and expand, we commit to our statewide membership that we will be on the front lines and serve as a voice for the voiceless."
But Planned Parenthood and others say the reelection of President Barack Obama and Democratic Sen. Sherrod Brown are proof positive that voters don't support the kind of legislation backed by Right to Life groups.
"The Grand Old Party wants to go back to the old days when women were barefoot and pregnant, home to make dinner by 5 p.m.," said state Sen. Nina Turner, a Democrat from Cleveland who sported a T-shirt reading "GOP: Get Out of Our Panties" during a press conference at the Statehouse. "... It's funny how they want small government, but they want government small enough to fit in a woman's womb."
Marc Kovac is the Dix Capital Bureau Chief. Email him at email@example.com or on Twitter at OhioCapitalBlog.


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On these pages you will find obituaries from the Union City Evening Times, June 1934-March 1939 and the Union City Times-Gazette, May 1939-December 1949 (April 1939 was not filmed and there are missing issues in 1942). With these exceptions the file covers the latter seven months of 1934 through the end of 1949. There are now over 8,500 obituaries (8,613) in this set of pages. The scope of the obituaries reaches far beyond the city limits of Union City to the surrounding counties and even states. In addition to coverage of Randolph County, Indiana, there are many, many residents of Darke County, Ohio to be found on these pages.
This collection was meticulously read and typed by Billy J. Baker, a former Union City resident. To Billy we give a huge "Thank You!" for providing DCOWeb with this most informative and interesting resource.
Now Available on DCOWeb
Darke County Websites:
DCOWeb Home
| Jane's
| Wally's | Wayne's
Darke County Websites: DCOWeb Home | Jane's | Wally's | Wayne's


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Sitting on the can without a smartphone—much like sitting at the bar without a smartphone—is soooo boring. What are you supposed to do with yourself? Be alone with your thoughts? Talk to the person on the toilet/stool next to you? Ugh.
This video from the nice folks at College Humor totally nails our modern smartphone addiction. It's ruining our ability to keep our minds occupied when there's nothing to do. I'll be leaving my phone at my desk before the next poop I take.


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I'm going out on a limb saying it, but here's my brief prediction — probably worthless, overdramatic and ill-informed, but my prediction anyway: Xubuntu's push toward Gnome applications is going to marginalize the distro.
My logic: First, the Xubuntu user base is nowhere near as hefty as the Ubuntu crowd. (Kubuntu is small too, but not as slim as Xubuntu.) The polls — here and here — regarding Gnome applications got only sparse replies. And while the xubuntu-dev and xubuntu-users mailing lists are sometimes active, much in the past week or two has been bickering between developers. It doesn't suggest a buzz of activity.
Second, if this Gnomeward trend is followed, then the only difference between Ubuntu and Xubuntu is going to be the desktop manager. Even the layout is already the same. Everything else — the session manager, the utilities, the applications and so on — are probably going to be borrowed from the Gnome version.
Furthermore, there has to be a certain cost involved in keeping another "official" version of Ubuntu around. I couldn't tell you what it would be, or who pays it (Canonical?), but I'm sure there's some sort of weight attached to the project.
So in total, we have a complete and full distro which has a slim following, that is almost indistinguishable from the most popular version, contains the same software as its bigger brother, and incurs some sort of expense — bandwidth, server space, whatever — to somebody somewhere, probably in an office on the Isle of Man.
So that's how I arrive at this doom and gloom. If Xubuntu keeps incorporating Gnome-based software into its default structure, then really, the separate version becomes moot, and I would not be surprised if it were demoted.
Oh, I'm sure there would still be a xubuntu-desktop, and probably some unique wallpaper and the prerequisite XFCE structure. But aside from that, will there still be, for example, entire Xubuntu ISOs? Hmm. …
Of course I'd rather be wrong. I still love Xubuntu more than either of its fat sisters, and I'd sooner install Xubuntu on any computer I own than just about any other full distro. I just don't like the direction it's headed, and that's why I'm screaming "Don't do it!" from my rooftop.
But there are other XFCE-based distros, and some of them are exceptional collections — SLAX Popcorn for one, or Wolvix and Zenwalk, as others. If you need a distro that will make your computer go zoom, and if Xubuntu is really just Gnome with a thin lacquer of XFCE on it, which are you likely you try?


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Food Artisans: Purely Elizabeth Granola
A different New York artisan every week.
Elizabeth Stein was working as a holistic nutrition counselor when she decided to start a food company. "Providing guidance toward a healthier lifestyle was something that was really important to me," she explains. To that end, Purely Elizabeth launched in 2007 with a line of baking mixes that were vegan, sugar- and -gluten free, and organic.
"The idea was to get people in their kitchen and get closer to their food," Stein says, adding, "If we all cooked at home, we'd be a lot healthier!" However, she quickly came to realize that many of her customers were interested in buying food that was ready to eat and since, as she says, "so many of the gluten-free and vegan products on the market were overly processed and didn't taste good," she expanded into ready-to-eat granola made with healthful ingredients like amaranth, chia, and quinoa.
Now the granola, in flavors like Pumpkin Fig, Blueberry Hemp, and Cranberry Pecan, are her best-selling product.
In addition to an online shop and information about her products, the Purely Elizabeth site includes resources for healthy living, like recipes and two free e-cookbooks written by Stein, Hemp Seeds and Winter. She explains that she "wanted to have this platform to educate and encourage people to live a healthy lifestyle." That doesn't mean one has to be fully committed to veganism or life without gluten to enjoy her products though. "I like to think that our products are for those living a healthy lifestyle, but the products just happen to be gluten free or happen to be vegan," she says, "I think anyone who tries the granola instantly falls in love."
All products linked here have been independently selected by our editors. We may earn a commission on purchases, as described in our affiliate policy.


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(Maps tagged with 2009)
Maps with a release in 2009.
These dates reflect original map releases as well as major updates.
image size: small / large
sort by: A-Z / rating
Can't find what you're looking for? Note that maps with fewer than 5 votes are automatically hidden when sorting by rating.


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|editHayama Shirakumo
|白雲ハヤマ Shirakumo Hayama
|Naruto Shippūden Episode #190
|Naruto the Movie: Blood Prison
|Appears in
|Anime, Movie
|Voice Actors
|Ninja Rank
Hayama Shirakumo (白雲ハヤマ, Shirakumo Hayama) is a jōnin of Konohagakure.
He was assigned to patrol the northern borders along with Tekuno Kanden, Naruto Uzumaki, and Kosuke Maruboshi after the Konoha Crush. Not long after they were ambushed by a battalion of ninja from Iwagakure. Hayama stayed behind to allow the other members of the squad time to escape and report to the village. Along with Tekuno, he wiped out the majority of the ninja.
Hayama is a very quiet, calm and collected individual able to carefully assess situations and formulate strategies around that making him a good leader. He also has a great sense of duty to Konoha and to his subordinates that he'd rather protect than ever think of sacrificing.
Hayama has long dull dark-grey hair held in a ponytail. He also has a scar running down the right side of his mouth and pronounced tear troughs under his eyes. He wears the standard Konoha shinobi outfit, albeit his uniform has short sleeves and like Tekuno, the traditional red, swirl pattern was only on his left shoulder sleeve. He also wears a pair of fingerless gloves and carries a thin katana strapped horizontally to his back.
Hayama has shown himself to be an undoubtedly skilled ninja. He is very adept at the use of kenjutsu which he uses in tandem with wind-nature transformation to create sharp blades of winds which are capable of serving multiple purposes. It can be used directly to attack his opponents, causing severe damage, or else be used to buffets them. The technique can also be used to counter incoming projectiles. He is also proficient with the Body Flicker Technique, in which he uses leaves to mask his movements.
In addition, his years of experience has made him a highly analytical combatant and a adept strategist. This was seen not only in battle but during his preparation for one mission where he chose to take Kosuke Maruboshi on their mission because of his expertise.
Part II
Past Arc: The Locus of Konoha
Following Pain's assault on Konoha, he and the other villagers aided in the restoration of the village after the invasion.
In Other Media
Naruto the Movie: Blood Prison
During Naruto's flashback to the members of the village when he was gathering natural energy to enter Sage Mode, Hayama can been seen alongside, Tekuno and some other villagers.
- "Shirakumo" (白雲) means "white cloud", while hayama, when written as 端山, means "foothill".


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A little more
I'm originally from Skipton in North Yorkshire, spending the first 21 years of my life there. I went on to study Immunology at Glasgow University, followed by an MSc in Information Technology.
I've spent a little time out of the country since moving from Skipton, including working in an Immunology laboratory in Tokyo. London as I say above is where I call home at the moment, living with my girlfriend Suzanne in the borough of Hammersmith.
I've a few interests outside of work, including photography, cycling and of course music.
Instead of adding a link, I've decided to add a little text about a few of the simple things that make me happy. The first is my bike, which I love because I built (put together) it from scratch. To those pedantic types out there, no this does not mean that I made the parts myself, what it actually means is that I picked all the parts myself, and assembled them into the frame that I ordered.
Bike parts:
- Bob Jackson Vigorelli frame (22½")
- Phil Wood Hubs and Bottom Bracket
- Campagnolo Record Headset
- Deep V rims laced with Phil Wood spokes
- Sugino 75 Cranks
- ... if you're still interested, speak to me, I'm more than happy to talk about my bike.
I love music, and have done for some years. It's hard to say what influenced me, although my dad's love of Motown was possibly a contributing factor. I sadly don't spend as much time listening to and discovering new music as I would like, although Suzanne bought me a set of Grado headphones which should certainly help (they really do sound amazing).


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There, I had the chance to read and listen to this show: Dog Talk: Life in a Dog-Eat-Dog World. This VOA Special English program, WORDS AND THEIR STORIES, was written by Jill Moss and read by Faith Lapidus.
There you can read about the many uses of the word DOG in different expressions. As I mention before this is a podcast which means you can listen to the article or download it to your computer or I pod to listen to later.
Any way, here there are some of the things I learned from it and wanted to share with you.
- Dog's life: carefree existence. Dogs have no troubles or responsibilities. They can come and go as they please, sleep all day, and never have to work.
- Dog-eat-dog world: That means many people are competing for the same things, like good jobs.
- Work like a dog: according to this a person has to work really hard to be successful.
- Dog-tired: When you work really hard you will feel like a really tired dog.
- Sick as a dog: you feel really sick.
- Every dog has its day. This means that every person enjoys a successful period during his or her life.
- You can never teach an old dog new tricks. using this expression means that you believe that older people do not like to learn new things and will not change the way they do things.
- Meaner than a junkyard dog: People who are unkind or uncaring can be described this way.
- His bark is worse than his bite: Sometimes a person appears to be mean and threatening but is really not so bad.
- In the Doghouse: married people used this term when they are angry at each other and they may not treat each other nicely until they apologize to each other.
- To let sleeping dogs lie: It means it's better to leave things as they are.
- The dog days of summer: these are the hottest days of the year.
- To rain cats and dogs: we use this when it rains really hard.
* photo by BryonRealey


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As one who was 17 and pregnant, Bristol Palin has expressed her support for the gritty MTV show "16 and Pregnant."
"I hope other young girls and even young guys should know that having a child is not glamorous at all," Palin told MTV.com.
The MTV documentary follows expectant teenage mothers as they try to live with the consequences of early pregnancy. It's not pretty, and unlike other shows, does not "glamorize sex," Palin said.
"They make it seem like there are no consequences to it. But there are tremendous consequences," she added. "'16 and Pregnant' shows that."
The daughter of Sarah Palin has just completed an anti-teen pregancy PSA. She perked up when she talked about her latest mommy highlight with son Tripp, his first giggle.
"That was the biggest moment to me. It made me feel totally like a mom," she said. "I was so proud of something like that."


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Year in Review
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At the end of each year, we reflect.
We remember challenges and triumphs.
We celebrate the moments that connect us.
Continue to take a look back on 2014.
Swipe to take a look back on 2014.
World Cup
The 2014 FIFA World Cup in Brazil drove more conversation than any other event in Facebook history.
Ebola Virus Outbreak
Since March, the most widespread Ebola outbreak in history has claimed the lives of thousands of people.
Elections in Brazil
This year's presidential election in Brazil was one of the most discussed and hotly debated in the country's history.
Robin Williams
In August, actor and entertainer Robin Williams passed away.
Ice Bucket Challenge
Between June and September, people around the world shared more than 17 million Ice Bucket Challenge videos on Facebook to raise awareness for ALS, a neurodegenerative disease.
Conflict in Gaza
In July, ongoing tension between Israelis and Palestinians erupted into a conflict that lasted seven weeks.
Malaysia Airlines
The world took notice when two Malaysia Airlines planes were lost within months of each other.
Super Bowl
In February, the Seattle Seahawks beat the Denver Broncos, 43-8, to win Super Bowl XLVIII.
Michael Brown / Ferguson
The shooting of unarmed teenager Michael Brown by a police officer in Ferguson, Missouri, led to protests and heated debates in the US and abroad.
Sochi Olympics
In February, the 22nd Winter Olympic Games commenced in Sochi, Russia.
The moments we shared in 2014 affected us all.
They shocked, moved and entertained us.
They connected us.
Together, let's make 2015 amazing.


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This past March, the 20th Conference on Retroviruses and Opportunistic Infections (CROI) brought an unprecedented flurry of mainstream interest in potential HIV cure strategies. TheBodyPRO.com's Nelson Vergel sat down with leading HIV cure research activist Richard Jefferys for an update on current important aspects, and controversies, in HIV cure research. Jefferys, who coordinates the Basic Science Vaccines and Prevention Project at Treatment Action Group in New York City, is at the forefront not only of gathering data and information from different studies, but also of educating other activists on the new language of immune-based therapies. Read Part Two of this conversation.
Richard, we just attended the 2013 Conference on Retroviruses and Opportunistic Infections (CROI) in Atlanta in March. Could you let us know a little bit about what's been going on with cure research? With the reports from the conference about the baby that was cured, which got a lot of media exposure, people are a little confused, so let's start with that and then expand into the different cure studies presented at the conference.
That was obviously the story that dominated the meeting, although there were other interesting presentations.
I think it was a confusing case. The media coverage has not been all that easy to follow and it's also unclear whether the case has relevance to the adult situation or not. I think they're hoping to shed more light on that in the future. But right now the only thing that they seem to be able to say clearly is that there was good evidence that the infant was infected in utero, so before birth, and received very early treatment with antiretroviral therapy. Then, when there was an unscheduled stop of therapy around 18 months later, there was no rebound. Then the child and the mother were lost to care for several months. When they returned for care, there was no detectable HIV viral load, despite the fact that the child had been off treatment.
That's what led the clinician to involve other scientists in the case who looked for evidence of virus in the infant's body and could only find some bits and pieces of possible DNA, but no replication-competent virus, no active virus and no immune responses. Perhaps the very early institution of therapy, rather than a preventive regimen, prevented the formation of a reservoir of latently infected cells and that meant that there was no rebound in virus when treatment was stopped.
Perhaps the very early institution of therapy, rather than a preventive regimen, prevented the formation of a reservoir of latently infected cells and that meant that there was no rebound in virus when treatment was stopped.
Some people say that other babies have cleared the virus in the past due to the natural tendencies for a baby's immune system to basically regenerate itself after birth. Can you explain this? I think you wrote a piece in your blog about this issue.
There were isolated case reports in the scientific literature during the 1990s of infants who appeared to be infected with HIV based on PCR testing for HIV DNA, but later showed no evidence of infection. It was proposed that they may have cleared the infection on their own.
What happened, though, is that there was a research group who investigated many of those cases looking at the genetic sequences of the virus to see if it was connected to the mother's virus. In all the cases they looked at, there seemed to be other explanations for what happened -- including cases of sample mix-ups where the sample wasn't actually from the child, and apparent false-positive PCR readings.
Although not every case has been formally ruled out, the paper that was published on this observation was in Science in 1998 with Lisa Frenkel, M.D., as lead researcher. They set out some criteria for proving transient infection in infants and so far, as far as I know, there haven't been any reports since then. So, although it's theoretically possible that this child was going to clear the infection on her own, the evidence for that happening in the past is not convincing and so this does seem to be an exceptional case.
Another study that has been mentioned for a few years and is getting new attention is the VISCONTI study. Can you explain this study to people who are not familiar with it? I understand that it included some patients who started HIV treatment early in their infection who later stopped treatment. After they stopped HIV medications, some of these people seemed to continue to have very low or undetectable viral loads for years.
The term "post-treatment controllers" is being used more often because of this study and some other individual case reports. The interesting thing about the VISCONTI study is that it does seem more directly relevant to adults with HIV infection.
Essentially, they've identified 14 people that were treated early and stayed on treatment for quite some time -- I think around three years on average -- and they have been able to maintain extremely low levels of virus after stopping treatment, in some cases up to 10 years now off treatment, which is obviously very exciting.
The terminology that's being used in cure research now has become a little bit confusing. Researchers are reluctant to refer to this group necessarily as being functionally cured because they're not sure how long the effect of treating early is going to last, so they are cautiously calling this a type of "drug-free remission."
It was not Timothy Brown, but a different patient in Berlin in the late '90s, who was treated for acute infection and maintained viral load less than 50 copies off treatment for many years.
I think what it really calls for is a more systematic effort at a search for cases like these, where people have stopped treatment for some reason and been able to maintain control. Because although the VISCONTI cohort represents probably the largest number of people with the longest-term follow-up, there have been a number of case reports over the years since that have some similarities. The most famous probably is the original "Berlin patient." It was not Timothy Brown, but a different patient in Berlin in the late '90s, who was treated for acute infection and maintained viral load less than 50 copies off treatment for many years.
There are a few conference presentations and case reports of similar individuals. Giuseppe Pantaleo, M.D., and Jan van Lunzen, M.D., have each presented a case. There's just a lack of any kind of systematic analysis and I think it would be productive for researchers to try to come together to assess how common this is and to try and do a more comprehensive job of identifying factors that may predict somebody's ability to safely go off treatment.
[Editor's note: Dr. van Lunzen presented data at IAS 2013 on a functional cure for a German patient who had started treatment within a month after being infected.]
The interesting thing about this study was the fact that they could not predict or find out what made those people special. Why were these 14 people able to control their virus post interruption while many others who started treatment early did not? How do these "post-treatment controllers" differ from elite controllers, who have never taken HIV medications but remain with very low viral loads for years and years without any antiretrovirals?
One of the differences is that most elite controllers have strong immune responses to HIV that are quite easy to detect, particularly CD8 cell responses that are responsible for identifying and killing virus-infected cells. Those responses seem to be important in a lot of elite controllers. One of the interesting differences with the VISCONTI cohort members is that, in general, they don't seem to have particularly strong responses.
Also, there are immune response genes that you inherit, and some of them seem to be particularly good in terms of allowing the immune system to recognize and respond to HIV. Elite controllers often have these kind of good immune response genes and I think only three of the 14 VISCONTI cohort members have these kind of genes. In fact, quite a few of them had immune response genes that in untreated infection have been associated with faster disease progression rather than slower. If there's something to that, in terms of an interaction between their immune response genes and the long-term treatment that they were on, it's not clear yet, but it's a line of inquiry that the researchers are pursuing.
The other missing piece of the puzzle is that one of the immune responses that seems key in elite controllers is not the CD8 response, but the CD4+ T cell (T-cell helper) response targeting HIV. There's been no information presented on CD4+ T-cell responses to HIV in the VISCONTI cohort members. So whether there is something different going on there is not known yet.
Do we have data that shows how fast HIV populates the different reservoirs of the body after infection? What would be the optimum or longest time to wait to start treatment to attempt to be one of these post-treatment controllers? When is the point of no return when we have so much virus in different reservoirs that we would be unable to control virus replication after treatment interruption?
That's a really good question. There was a study presented at CROI by a Thai researcher, Jintanat Ananworanich, M.D., which involves probably one of the largest cohorts of people treated early that has ever been recruited. They break down stages of acute HIV infection into these different categories called Fiebig categories based on research on defining different stages of infection. Ananworanich's study has a lot of people in Fiebig 1, which is where there's virus detectable, but no beginnings of an antibody response, and those individuals are being treated. There are people in Fiebig 1 through 4, so various time points after acute infection, all being treated with antiretroviral therapy. There are plans to do an interruption in therapy in that cohort. So that really should help answer the question if there's a point early enough that will predict prolonged control because the formation of the reservoir has been inhibited.
That's probably also the closest adult parallel to the infant case in that people in Fiebig stage 1 are very, very soon after infection. It might be an opportunity to see whether the formation of a significant reservoir can be prevented in adults.
In terms of animal studies, there were some conducted by a researcher named Jeff Lifson in the '90s who administered tenofovir [Viread] to macaques very shortly after a challenge with a pathogenic SIV -- the simian cousin of HIV. If the drug was administered within 24 hours after the challenge, most of those animals showed prolonged control or even an absence of signs of infection after drug withdrawal; so there may be reason to think that very, very early treatment can lead to prolonged control if treatment is later interrupted.
I am very concerned about the fact that if someone presumes that they have been infected with HIV it is very difficult for them to get early treatment after they get tested. Personally, if I was to get infected right now with HIV, after reading all this information, I would be really compelled to not wait too long and to not allow my reservoirs to be populated by HIV. The lucky ones who accomplish this may have a better chance to be cured when the day comes.
Regarding the effects of early treatment on preventing HIV's spread into body compartments, I'm also following some of the work done in measuring how well some HIV antiretrovirals penetrate the different reservoirs. The VISCONTI cohort was exposed to older HIV drugs that may not penetrate as well, so I wonder if we would have seen more post-treatment controllers if they were provided drugs in the integrase class, which seems to penetrate well and quickly into reservoirs. Could you explain what we're seeing so far?
There is some evidence that there can be ongoing replication in different tissues where drugs are not penetrating so well.
So, one of the big controversies in this research is the extent to which ongoing viral replication may contribute to virus persistence despite treatment. There is some evidence that there can be ongoing replication in different tissues where drugs are not penetrating so well. Probably the best evidence is that protease inhibitors may not be penetrating into the lymph tissue and into the gastrointestinal [GI] tract as well as other drugs. Recent studies are suggesting that the integrase inhibitor raltegravir [Isentress] penetrates very well into the GI tract. There was a study presented by Hiroyu Hatano, M.D., from UCSF, at CROI that added raltegravir to antiretroviral therapy in an intensification strategy. She did report some evidence that people that received that strategy showed additional declines in markers of inflammation and that viral replication was being inhibited. Similar to some other studies, it seemed that participants on a protease inhibitor-containing regimen had this additional suppression with raltegravir.
There is a large, ongoing study looking at different drugs and tissues being conducted at the University of Minnesota. It involves several different research teams: Timothy Schacker, M.D., looking at the tissues; Courtney Fletcher, Pharm.D., looking at drug levels; and Mario Stevenson, Ph.D., looking at viral measures. Some preliminary results from that ongoing study have been presented, but I think probably the full publication of the results will shed significantly more light on that issue.
Going back to VISCONTI's 14 patients that were shown to control virus after they had stopped treatment: I was very surprised to see that some of those patients only took nucleosides or even dual therapy and got to that point of control after interruption.
It really struck me that maybe the type of treatment that they start at the beginning is not as important as starting treatment of some kind. I'm interested in further research that's hopefully going to be available soon, so that we can have a better understanding of what treatments to start with to treat early infection, and things that can actually change the current guidelines. They don't really specify what type of treatment to start with, just basically any of the first-line therapies that are available right now. That's something that I think is very interesting. Obviously, people that are reading and have friends or family that may unfortunately find out that they have been exposed to HIV will at least have a higher awareness of the fact that it's very important to start treatment early, even if they don't really know their CD4+ and viral load numbers.
Are there any other updates from CROI that I haven't mentioned when it comes to reservoir testing? I think there are some other indications that current testing is underestimating HIV reservoir size. Can you explain the data presented at CROI on testing of the reservoirs?
Because in most people the reservoir is relatively small, there's a needle-in-the-haystack aspect of trying to find and quantify how much of a reservoir is there, how much of it is actually made up of virus that can replicate and might rebound when treatment is stopped. It's technically just a very challenging thing to do.
I think one of the encouraging things is that oftentimes in research it's very hard to get different groups to collaborate with each other. In terms of measuring the reservoir, there has been a big collaboration that's seen multiple laboratories with different kinds of tests compare their different tests to see how well they perform in comparison with each other and whether they correlate with each other. Labs would all like to believe that their test is great, and so there is considerable compromise involved in engaging in that collaborative process, which they've all done.
The results are not great, in that each test may be showing something useful, but they don't seem to link very well together. HIV DNA is one thing that can be measured, but a lot of the HIV DNA, it turns out, is kind of dead-end defective virus that can't really replicate; so it's not clear whether you really need to measure all of it.
The gold standard is trying to do what they call viral outgrowth, or measuring how much virus can actually replicate in a sample.
The gold standard is trying to do what they call viral outgrowth, or measuring how much virus can actually replicate in a sample. It involves taking quite a lot of cells from somebody and it's quite difficult to do, but that still seems to be the best guide to how much virus is there.
The other kinds of tests don't seem to correlate too well, although there is one test developed by Una O'Doherty, M.D., at the University of Pennsylvania, that looks for HIV DNA that's integrated into the genome of the cell. And that does seem to correlate better with how much replication-competent virus can be detected. I think there's work going on now to try to streamline those tests so that you can get a clearer and more reliable sense of what impact an intervention is having on the size of the reservoir, because that's obviously crucial in terms of deciding whether you want to look at things like treatment interruption.
Bob Siliciano, M.D., who has really pioneered a lot of the latency research, did present a new model suggesting that, if you can push down the levels of the reservoir by several logs, it would predict at least a delay, possibly of several years, in the rebound of virus. That's obviously something that needs to be further confirmed as interventions develop which reduce the reservoir.
This transcript has been lightly edited for clarity.
Read Part Two of this conversation.
Read TheBodyPRO.com's multi-author blog, HIV Care Today.


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