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Novel Vaccine Concept Developed: Protein from Herpes Virus Serves as Potent Vaccine Enhancer
31-Jan-2008 11:00 AM EST
Available for logged-in reporters only
Nature Medicine (6-Feb-2008)
Newswise — Creating vaccines to protect people against viral diseases like AIDS, cervical cancer and infectious hepatitis is a delicate balancing act: If the immune system's response to the vaccine is too strong, toxic side effects can kill the patient. If it's not strong enough, the virus will spread faster than the immune system can kill it.
A new vaccine design strategy developed by scientists at The Wistar Institute Vaccine Center could be the answer. The secret is using a herpes simplex protein called glycoprotein D to block a specific receptor molecule on antigen-presenting cells, or APCs. These sentinel cells monitor the body for foreign antigens " molecules that can stimulate an immune response " from invading viruses.
When they detect viral antigens, APCs signal the body's immune system to activate T cells to attack and destroy cells infected with the virus. At the same time, they also send inhibitory signals to prevent overreaction by the immune system. One of thee inhibitory signals is blocked by glycoprotein D from herpes virus.
In a study that will be published February 6 in Nature Medicine and is available online, Wistar scientists showed that vectors, which are vaccine delivery systems, made by fusing the glycoprotein D with genes from target antigens increase the immune system's response to those antigens in cell cultures and laboratory mice. The researchers used antigens from HIV, the virus that causes AIDS, and from HPV-16, a human papilloma virus that causes cervical cancer.
Hildegund C.J. Ertl, M.D., director of The Wistar Institute Vaccine Center and senior author of the study, says using glycoprotein D to deliver antigens has a major advantage over other vaccine approaches. "It allows us to lower the dose but still get a stronger immune response," she says.
Glycoprotein D is part of the herpes viral envelope and is expressed on the surface of cells infected with the herpes simplex virus. Glycoprotein D binds to a receptor molecule called HVEM (herpes virus entry mediator) on antigen-presenting cells. By locking onto the HVEM receptor, glycoprotein D prevents HVEM from binding to another molecule called BTLA on T and B lymphocytes " white blood cells that attack disease-causing pathogens.
Binding between HVEM and BTLA is the first step in an inhibitory signaling pathway that reduces the immune system's response to the presence of a virus. Blocking this inhibitory pathway allows the body to mount a stronger immune response by generating more antigen-specific CD8+ T cells to attack cells infected with the virus.
The researchers found that fusing HIV and HPV antigens to glycoprotein D enhances the immune response to those antigens. Mice injected with vaccines that included antigens fused to glycoprotein D generated more virus-killing CD8+ T cells than mice injected with the same vaccines and antigens, but without the glycoprotein D carrier protein.
Researchers also inoculated identical strains of laboratory mice with vaccines containing genes for the cancer-causing proteins E7, E6 and E5 from the HPV-16 virus. One group of animals received HPV-16 genes spliced into the genetic code for glycoprotein D; another group received the same antigens without glycoprotein D. Ten to 14 days later, both groups of animals were injected with a fast-growing tumor cell line that normally generates extensive tumors in mice within 14 days.
Mice that received vaccines with the glycoprotein D-antigen combination were fully protected against cancer, says Wistar's Marcio Lasaro, Ph.D., lead author of the study. However, mice inoculated with vaccines containing the same HPV-16 genes, but without glycoprotein D, developed tumors after being inoculated with the same tumor cell line.
"It's important to point out that the molecules we targeted in mice are similar to those in humans, and all the basic in-vitro studies in the paper were done with human molecules, making it likely that the method will also work in people," Lasaro says.
Ertl says the ability of the glycoprotein D carrier protein to enhance the immune response could be particularly important to the development of a long-sought vaccine for AIDS. "The problem with HIV vaccines is that they might look good in mice and primates, but comparable doses in humans are too toxic," she says. "If you lower the dose to avoid toxic side effects, you don't get the immune response you need." She believes that using glycoprotein D may solve that problem.
Ertl and her colleagues are planning future studies to further elucidate the mechanism behind the carrier protein's effectiveness. If studies in research animals continue to be positive, they hope to conduct human clinical studies with HIV and HPV vaccines currently under development at The Wistar Institute Vaccine Center.
The Wistar Institute has filed for patent protection on the glycoprotein D carrier protein technology.
Ertl is corresponding author of the study. Wistar co-authors are Nia Tatsis, Ph.D., Shih-Wen Lin, John J. Rux, Ph.D., E. John Wherry, Ph.D., and Scott E. Hensley (now at the National Institute of Allergy and Infectious Diseases). Lin is also affiliated with the University of Pennsylvania. J. Charles Whitbeck, Gary H. Cohen, and Roselyn J. Eisenberg are with the University of Pennsylvania.
The research was supported by the National Institute of Allergies and Infectious Diseases (NIAID) and the Commonwealth Universal Research Enhancement Program of the Pennsylvania Department of Health.
The Wistar Institute is an international leader in biomedical research with special expertise in cancer research and vaccine development. Founded in 1892 as the first independent nonprofit biomedical research institute in the country, Wistar has long held the prestigious Cancer Center designation from the National Cancer Institute. Discoveries at Wistar led to the creation of the rubella vaccine that eradicated the disease in the United States, human rabies vaccines used worldwide, and a rotavirus vaccine approved in 2006. Today, Wistar is home to preeminent research programs studying skin cancer, lung cancer, and brain tumors. Wistar Institute Vaccine Center scientists are creating new vaccines against pandemic influenza, HIV, and other diseases threatening global health. The Institute works actively to transfer its inventions to the commercial sector to ensure that research advances move from the laboratory to the clinic as quickly as possible. The Wistar Institute: Today's Discoveries " Tomorrow's Cures. On the web at www.wistar.org.


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NEW YORK (Reuters) - Stocks rose to five-year highs on Friday, with the Dow closing above 14,000 for the first time since October 2007, after jobs and manufacturing data showed the economy's recovery remains on track.
The S&P touched its highest since December 2007 after a 5 percent gain in January, which was its best start to a year since 1997. The index is now just about 60 points away from its all-time intraday high of 1,576.09.
Employment grew modestly in January, with 157,000 jobs added. That was slightly below expectations, but Labor Department revisions showed 127,000 more jobs were created in November and December than previously reported.
Analysts attributed the market's robust showing so far this year partly to a deluge of cash flowing into equities.
Investors poured $12.7 billion into U.S.-based stock mutual funds and exchange-traded funds in the latest week, concluding the strongest four-week flows into stock funds since 1996, data showed on Thursday.
"There is a lot of money looking for a home, and people are finally deciding the bond market is done and moving money into equities," said Edward Simmons, managing director and partner at HighTower in Portland, Maine.
"I see the rotation (of assets) pushing the market up in the face of not-massive amounts of good news," he said. "People are overlooking the higher risk in equities."
Other reports released Friday showed the pace of growth in the U.S. manufacturing sector picked up in January to its highest level in nine months, U.S. consumer sentiment rose more than expected last month, while December construction spending also beat forecasts.
"All the data seems to keep pointing to a slowly, steadily improving economy," said Eric Kuby, chief investment officer at North Star Investment Management Corp in Chicago.
The Dow Jones industrial average .DJI was up 149.21 points, or 1.08 percent, at 14,009.79. The Standard & Poor's 500 Index .SPX was up 15.06 points, or 1.01 percent, at 1,513.17. The Nasdaq Composite Index .IXIC was up 36.97 points, or 1.18 percent, at 3,179.10.
With the day's gains, major equity indexes rose five straight weeks.
More than 600 stocks on the NYSE and the Nasdaq combined hit 52-week highs on Friday, including Google GOOG.O. which rose as high as $776.60, before closing at $775.60, up 2.6 percent.
Investors were also attuned to corporate earnings, with a trio of Dow components reporting profits that beat expectations.
Exxon Mobil (XOM.N) ended flat at $90.04 after reporting results while Chevron (CVX.N) added 1.2 percent to $116.50.
Drugmaker Merck & Co (MRK.N) fell 3.3 percent to $41.83 after a cautious 2013 outlook.
Generic drugmaker Perrigo PRGO.O reported a better-than-expected second-quarter profit and its shares jumped 4.7 percent to $105.28.
Of the 252 companies in the S&P 500 that have reported earnings so far, 69 percent have exceeded expectations, according to Thomson Reuters data. That is a higher proportion than over the past four quarters and above average since 1994.
Overall, S&P 500 fourth-quarter earnings are estimated to have grown 4.4 percent, according to the data, up from a 1.9 percent forecast at the start of the earnings season but well below a 9.9 percent profit growth forecast on October 1.
Dell Inc DELL.O gained 2.9 percent to $13.63 after sources said the company was nearing an agreement to sell itself to a buyout consortium led by its founder, Michael Dell, and private equity firm Silver Lake Partners.
Reporting By Angela Moon; Editing by Kenneth Barry

subset: commoncrawl


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text: Micro Precision Calibration Inc. is an ISO/IEC 17025:2005 Accredited Laboratories that perform Calibration traceable to International Standards. We are ISO 17025:2005 Registered and ANSI/NCSL Z-540.1-1994 Compliant. This allows Micro Precision Calibration Service to provide state-of-the-art test equipment calibration services that precisely measure scale, flow, force, torque, weight, pressure, temperature, optical and calibrate almost any mechanical, electronic, or dimensional instrument.


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Dark Brown light weight wool & linen classic formal blazer from Canali featuring a structured shoulders, notched lapels, a tailored design, patch pockets and a chest pocket.Condition New with tagsSize - 52Fabric - 60%Wool -40% LinenChest - 43 inchesLength - 32 inches
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Dark Brown light weight wool & linen classic formal blazer from Canali featuring a structured shoulders, notched lapels, a tailored design, patch pockets and a chest pocket.Condition New with tagsSize - 52Fabric - 60%Wool -40% LinenChest - 43 inchesLength - 32 inches
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Graduate Student Scholarships
Wright State University offers several scholarship opportunities to graduate students, including:
- Graduate assistantships
- Tuition scholarships
- Fellowships
- Stipends
Often these awards require the student to serve in an employment-like capacity for the awarding department or college in order to be eligible and maintain eligibility.
Terms and conditions for graduate assistantships, tuition scholarships, fellowships and stipends can be obtained from the Graduate School's Policies and Procedures Manual.
Graduate students are encouraged to contact the chair of their program of study for information about graduate assistantships, scholarships, fellowships and stipends.
Graduate students can submit ONE online scholarship application to apply for multiple donor-based scholarships funded through the Wright State University Foundation and also scholarships funded by the University. The system will automatically match students with any scholarships for which they are eligible. Final awards will be determined by various scholarship committees. For more details on possible scholarship opportunities, use the scholarship search to see what you may qualify for.
The 2020-2021 Wright State University Online Scholarship Application deadline is February 1, 2020 at 11:59 p.m. Eastern Standard Time (EST).
Once you have submitted your application you will NOT be able to access it to make changes. However, you will be able to monitor the return of your Recommendation Form and make changes to your reference after the application has been submitted. You will log back into your scholarship application via WINGS Express. Once in your application, click on the "blue button" titled Recommendations.
Scholarship award decisions begin in the spring and continue throughout the summer. If a scholarship has been posted to a student's award notice, the student will receive the general Financial Aid Award notification email via their Wright State University email account. The Award Notice is available in WINGS Express.
(Currently the opportunities listed at the top of this page are not associated with this application. There may be other department/division scholarship options not yet associated with this application, so check with the chair or program director in your department for any other options.)
Wright State students can access the online scholarship application via WINGS Express. In WINGS Express select the Student and Financial Aid tab, then click on Financial Aid and Scholarships, and then click on *Online Scholarship Application.


text:
GPGPU stands for General-purpose computing on graphics processing units.
In Linux, there are currently two major GPGPU frameworks: OpenCL and CUDA
- 1 OpenCL
- 3 List of OpenCL and CUDA accelerated software
- 4 Links and references
OpenCL (Open Computing Language) is an open, royalty-free parallel programming framework developed by the Khronos Group, a non-profit consortium.
Distribution of the OpenCL framework generally consists of:
- Library providing OpenCL API, known as libCL or libOpenCL (
libOpenCL.soin linux)
- OpenCL implementation(s), which contain:
- Device drivers
- OpenCL/C code compiler
- Header files *
* only needed for development
OpenCL library
There are several choices for the libCL. In general case, installing libcl from the official repositories should do.
However, there are situations when another libCL distribution is more suitable. The following paragraph covers this more advanced topic.
The OpenCL ICD model
OpenCL offers the option to install multiple vendor-specific implementations on the same machine at the same time. In practice, this is implemented using the Installable Client Driver (ICD) model. The center point of this model is the libCL library which in fact imeplements ICD Loader. Through the ICD Loader, an OpenCL application is able to access all platforms and all devices present in the system.
Although itself vendor-agnostic, the ICD Loader still has to be provided by someone. In Arch Linux, there are currently two options:
- libcl by Nvidia. Provides OpenCL version 1.0 (even in the current version) and is thus slightly outdated. Its behaviour with OpenCL 1.1 code has not been tested as of yet.
- libopenclAUR by AMD. Provides up to date version 1.1 of OpenCL. It is currently distributed by AMD under a restrictive license and therefore could not have been pushed into official repo.
(There is also Intel's libCL, this one is currently not provided in a separate package though.)
For basic usage, libcl is recommended as its installation and updating is convenient. For advanced usage, libopencl is recommended. Both libcl and libopencl should still work with all the implementations.
To see which OpenCL implementations are currently active on your system, use the following command:
$ ls /etc/OpenCL/vendors
OpenCL implementation from AMD is known as AMD APP SDK, formerly also known as AMD Stream SDK or ATi Stream.
For Arch Linux, AMD APP SDK is currently available in AUR as amdapp-sdkAUR.
This package is installed as
/opt/AMDAPP and apart from SDK files it also contains a number of code samples (
/opt/AMDAPP/SDK/samples/). It also provides the
clinfo utility which lists OpenCL platforms and devices present in the system and displays detailed information about them.
As AMD APP SDK itself contains CPU OpenCL driver, no extra driver is needed to use execute OpenCL on CPU devices (regardless of its vendor). GPU OpenCL drivers are provided by the catalystAUR package (an optional dependency), the open-source driver (xf86-video-ati) does not support OpenCL.
Code is compiled using llvm (dependency).
Mesa (Gallium)
OpenCL support from Mesa is in development (see http://www.x.org/wiki/GalliumStatus/). AMD Radeon cards are supported by the r600g driver.
Arch Linux does currently (April 2014; Mesa 10.1.0; LLVM 3.4) not build Mesa with OpenCL support. See http://dri.freedesktop.org/wiki/GalliumCompute/ for installation instructions (use the development branches of LLVM and Mesa for optimal results).
You could also use lordheavy's repo. Install these packages:
- ati-dri-git
- opencl-mesa-git
- libclc-git
Surprisingly, pyrit performs 20% better with radeon+r600g compared to Catalyst 13.11 Beta1 (tested with 7 other CPU cores):
catalyst #1: 'OpenCL-Device 'Barts'': 21840.7 PMKs/s (RTT 2.8) radeon+r600g #1: 'OpenCL-Device 'AMD BARTS'': 26608.1 PMKs/s (RTT 3.0)
At the time of this writing (30 October 2013), one must apply patches [1] and [2] on top of Mesa commit ac81b6f2be8779022e8641984b09118b57263128 to get this performance improvement. The latest unpatched LLVM trunk was used (SVN rev 193660).
The Nvidia implementation is available as opencl-nvidia from the official repositories. It only supports Nvidia GPUs running the nvidia kernel module (nouveau does not support OpenCL yet).
The Intel implementation, named simply Intel OpenCL SDK, provides optimized OpenCL performance on Intel CPUs (mainly Core and Xeon) and CPUs only. Package is available in the AUR: intel-opencl-sdkAUR. OpenCL for integrated graphics hardware is available in the AUR through beignetAUR for Ivy Bridge and newer hardware.
For development of OpenCL-capable applications, full installation of the OpenCL framework including implementation, drivers and compiler plus the opencl-headers package is needed. Link your code against
Language bindings
- C++: A binding by Khronos is part of the official specs. It is included in opencl-headers
- C++/Qt: An experimental binding named QtOpenCL is in Qt Labs - see Blog entry for more information
- JavaScript/HTML5: WebCL
- Python: There are two bindings with the same name: PyOpenCL. One is in [extra]: python2-pyopencl, for the other one see sourceforge
- D: cl4d
- Haskell: The OpenCLRaw package is available in AUR: haskell-openclraw-gitAUR
- Java: JOCL (a part of JogAmp)
- Mono/.NET: Open Toolkit
- Go: OpenCL bindings for Go
CUDA (Compute Unified Device Architecture) is Nvidia's proprietary, closed-source parallel computing architecture and framework. It is made of several components:
- required:
- proprietary Nvidia kernel module
- CUDA "driver" and "runtime" libraries
- optional:
- additional libraries: CUBLAS, CUFFT, CUSPARSE, etc.
- CUDA toolkit, including the
- CUDA SDK, which contains many code samples and examples of CUDA and OpenCL programs
The kernel module and CUDA "driver" library are shipped in nvidia and opencl-nvidia. The "runtime" library and the rest of the CUDA toolkit are available in cuda. The library is available only in 64-bit version.
When installing cuda package you get the directory /opt/cuda created where all of the components "live". For compiling cuda code add /opt/cuda/include to your include path in the compiler instructions. For example this can be accomplished by adding -I/opt/cuda/include to the compiler flags/options.
Language bindings
- Fortran: FORTRAN CUDA, PGI CUDA Fortran Compiler
- Python: In AUR: pycuda-gitAUR, also Kappa
- Perl: Kappa, CUDA-Minimal
- Haskell: The CUDA package is available in AUR: haskell-cudaAUR. There is also The accelerate package
- Java: jCUDA, JCuda
- Mono/.NET: CUDA.NET, CUDAfy.NET
- Mathematica: CUDAlink
- Ruby, Lua: Kappa
Driver issues
It might be necessary to use the legacy driver nvidia-304xx or nvidia-304xx-lts to resolve permissions issues when running CUDA programs on systems with multiple GPUs.
List of OpenCL and CUDA accelerated software
- Bitcoin
- GIMP (experimental - see [3])
- pyritAUR
- aircrack-ng
- john-openclAUR
- cuda_memtestAUR - a GPU memtest. Despite its name, is supports both CUDA and OpenCL


text:
It may be a slow job market, but there's one sector that's booming: Tattoo removal. ABC News reports:
According to The Patient's Guide, a website comprised of 25 niche publications dedicated to skin care, laser tattoo removal has increased 32 percent over the past year, with many citing employment as a main reason for the treatment.
Dr. Jen Mundt of Delete Tattoo Removal in Phoenix tells ABC that for recent college graduates looking for a job and people who have lost jobs and are attempting to get back into the workforce, tattoo removal offers an edge. But going by the examples in the video package, the tattoos in question seem to be completely shitastic. We're not talking about well-thought-out works of art, we're talking about crappily designed, terribly located, objectively ugly tattoos. Which, you know, could be a good idea, regardless of employment status. Just don't expect it to be fun. At all.
[ABC News]
Earlier: What It Feels Like To Get A Tattoo Removed From Your Ass
Think Before You Ink: The Painful Process Of Tattoo Removal
I Hate My Tramp Stamp
Image via CREATISTA/Shutterstock.


text:
Nov. 2, 2012 -- Tofu, edamame, and soy milk may be healthy foods, but if you are a menopausal woman eating them, they may not do much to prevent hot flashes and night sweats.
That finding comes from a new study of 1,651 women. Researchers from the University of California, Davis, (UC Davis) followed the women for 10 years, starting when the women were in their 40s and early 50s.
None had menopause-related hot flashes when they enrolled in the study, but many experienced them over the next decade.
The study showed no evidence that women whose diets contained more soy were less bothered by hot flashes and night sweats than women who ate little soy.
The researchers say very few of the women took soy supplements.
The research examining the impact of soy on hot flashes has been mixed for both soy-rich foods and supplements, says North American Menopause Society (NAMS) Executive Director Margery Gass, MD.
"Typically if something works, even if all the studies don't show it, the majority will," she says. "That is not what we have seen in the soy (and hot flash) studies."
Estrogen, Soy, and Hot Flashes
Soybeans and foods made from them are rich in plant nutrients called phytoestrogens that are believed to act like a weaker version of estrogen.
Estrogen levels naturally drop during menopause. That's thought to trigger hot flashes and night sweats. Some people turn to soy foods and supplements to try to prevent these symptoms.
Asian women who live in countries where soy is a big part of the diet report far fewer hot flashes than women living in Western countries, and one theory has been that their diets protect them.
The new study, which appears in the March issue of the NAMS journal Menopause, included white, African-American, and Asian women in the U.S.
It differed from much of the previous research by excluding women who were already having hot flashes.
"We wanted to see if dietary phytoestrogens could prevent hot flashes in women who were not yet having them," says researcher Ellen Gold, PhD, a professor and chair of the UC Davis department of public health sciences.
This research is very preliminary, and Gold says even though the soy and hot flash studies are inconclusive, there is little downside to eating soy-rich foods or taking soy supplements.
"Many women cannot or won't take hormone therapy," she says. "I don't see anything wrong with taking soy supplements in reasonable doses. If it gives someone relief, ultimately that is what counts."


text:
If you have done business with me please leave feedback.
If you have done business with me please leave feedback.
Last edited by swe_crazy; 06-08-2012 at 12:44 PM.
Bought a Micromag from me: Fast payment, good communication, smooth transaction, AAAA++++
Bought another micromag mag from me: fast payment, excellent comm, smooth trans, AA++!
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He bought some stuff off of me, and it was a great deal. We have also done business on MCB before. I highly recommend swe-crazy, he's a good guy.
Thanks man!


text:
Olin Browne is looking forward to a home-cooked meal next week.
He has spent 12 weeks on the road playing on the Champions Tour or serving as a television analyst during the U.S. Open and British Open.
"I'm tired, but it's a really good tired," Browne said Wednesday at the TPC Twin Cities, site of this week's 3M Championship.
Three days earlier, the 52-year-old Browne won the U.S. Senior Open by three shots.
"I'm still foggy about what's been happening, I haven't slept a lot," he said. "I came right up here and I'm just trying to catch up."
Browne is likely not alone when it comes to the fatigue factor.
With three majors in a five-week span, it wouldn't have been surprising for some of the top Champions Tour players to take this week off. Instead, a full field is expected for the tournament.
Besides last week's event, the Senior British Open was held two weeks ago in England. The players have next week off before the Senior Players Championship.
"That wears on you," Browne said. "I'm really, really looking forward to going home next week."
Whether it's the course where players have shot low scores in recent years or some of the biggest galleries on tour, the 3M Championship has become a must-play event for the top golfers of the 50-and-over set. For the third straight year, admission is free.
"It's a fantastic field again," said Bernhard Langer, who chipped in on 18 to win the event two years ago.
Defending champion David Frost established a tournament scoring record with a 25-under 191 total last year, including a final-round 61. Mark Calcavecchia finished five shots back. The average winning score the last six years is minus-18.
Scores could be that low again.
The course received more than 1.5 inches of rain overnight Saturday, six-tenths of an inch Monday, and another quarter-inch Tuesday.
"If there are soft greens out here, look for guys to make a ton of birdies," said Browne, who tied for eighth last year at 15 under. "Guys do go deep here."
Most players refuse to predict a winning number.
"It's all relative to how you play," said David Eger, ninth in the season-long points race.
Fred Couples -- returning to competitive golf after missing two months with a back injury -- is scheduled to play the tournament for the first time, as is Minnesota native Tom Lehman, who is the course architect along with Arnold Palmer. Lehman is a three-time Champions Tour winner in 2011.
"You always want to play the best," Langer said.
Brad Faxon, an eight-time winner on the PGA Tour who turned 50 on Monday, is scheduled to make his Champions Tour debut this weekend.
"There's not many places people look forward to turning 50," said Faxon, who has struggled on the PGA Tour the past few years. "This is a fresh start. ... It's kind of a rebirth."
Browne hopes the week is another step in ending his up-and-down season. He finished in the top eight in five straight tournaments early in the season, but was better than 23rd just twice in his next nine starts.
His iron play was better last week, and he made a tweak when hitting his driver.
"It feels great," he said. "It certainly motivates me to continue doing what I'm doing so that I can do that or be able to do that more frequently. ... You get so few opportunities to do something like that, that, to me, the important thing was to embrace the challenge and do the very best I could."
How does he keep it going?
"I'll let you know on the weekend," he said with a slight smile. "I'm trying to get some rest, I'm having a hard time doing that. My phone is ringing off the hook and I've gotten a lot of emails. I'm trying to respond to all those people. It's really nice that people take the time, and I want to make sure I get back to them."
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for lawyers, where your legal tasks and requirements are sent
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several lawyers competing for your work, you can choose the
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We need your basic details only.
ruly is a community of people looking to seek, provide and share legal knowledge and services.
Signing in to ruly helps us verify everyone's identity.
Registering with Facebook/Google makes this a one click process.


text:
It's time for marketers to get serious about data
By Jeff Alford, SAS Insights editor
By now, most organizations, large and small, know that they need to collect data from their customers. The question then becomes, if everyone is collecting data, where is the competitive advantage? The advantage is in how you choose, distil and manage the data and then how you use it.
Think of it as data alchemy. And analytics can be your Philosopher's Stone, the secret ingredient that turns hoarded data into marketing gold. Recently, the Winterberry Group produced a paper, Data as Competitive Advantage, in which it surveyed more than 100 executives in marketing-related roles.
The paper draws its conclusions from the survey and provides supporting evidence from information gathered during the survey.
Don't just sit there, data, do something!
Based on the findings, here are some ways organizations can become more successful.
Analytics equals competitive advantage
It's not just about having data, rather it's about what you do with that data. According to the survey, nearly a third of panelists (all of whom characterize their organization as highly sophisticated when it comes to squeezing results out of their data} say that their analytics capabilities have led to a competitive advantage. If your organization is not getting every drop of data goodness, you can be certain that several of your competitors are.
Even modest data use results in greater differentiation
This means that taking action rather than sitting on your data waiting for an innovative idea to strike. Organizations that rank themselves as modest data users say that even their unremarkable efforts have made them stand apart from those competitors that do little or nothing with their data.
The single best thing you can do with your data is gain customer insights
More than 70 percent of those surveyed said that their biggest successes with their analytics programs have been with customer segmentation. And 40 percent said that enhancing the customer experience based on their needs and preferences has produced tangible benefits.
Small successes provide greater motivation
The survey revealed that, of course, senior leaders want all of their organizations' marketing efforts to have a significant effect on their revenue (and they should). But, while nearly all of those surveyed said that increasing revenue was a primary data objective, only about 12 percent said that their effort and reward levels were on par.
Why? This is an educated guess, but those not in the top bracket probably went into full-tilt data collection mode without have a clear, repeatable strategy in place. Okay, I don't want to say it, but . . . "walk before you run." Start with small projects and modest goals and build on top of, or expand upon, the projects that net tangible results.
What are others doing?
When respondents were asked to choose the sort of programs they would implement to enhance their data use, the survey listed these as the top five:
- Private market media buying.
- Cross-channel marketing metrics.
- Open market media buying.
- Customer analytics for strategic and operational insights.
- Omnichannel engagement.
And, finally, it's not just marketer's that need to get serious about data; it's now the responsibility of senior executives, too. Nearly 90 percent of survey respondent's agreed that leaders should own the enterprise data strategy, management and implementation if for no other reason than to provide a centralized perspective (i.e., without data silos).
What to read next
Want to know how to get closer to your goal of 1:1 marketing? Our white paper, Using SAS® to Deliver Analytically Injected Digital Personalization for Online and Offline Data, offers a phase approach for capturing clickstream data that can be used for real-time personalization.
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text:
Happy Thursday, lovelies! Are you already looking forward to the weekend? I got to confess I sort of am. Haha. Meantime, I'm guest-posting over at Miles of Styles today while Persis is away. I'm sharing on this charming cafe in Osaka. Curious to see how the inside looks? I say you won't be disappointed! Click on over to see more now!
Rest assure I'll still be continuing with the Tokyo posts :)
[image: Cafe Parabola]


text:
Vogelsong, Lopez in limbo as free agency nears
Giants have until late Monday before both players hit open market
SAN FRANCISCO -- If the Giants feel any urgency to retain Ryan Vogelsong and Javier Lopez, their top two performers whose futures are in limbo, they're hiding it well.
Vice president and assistant general manager Bobby Evans said succinctly, "No update," when asked Friday about the status of contract talks involving the pair of pitchers.
Something will happen by 2 p.m. PT on Monday.
Once that hour passes, Vogelsong will become a free agent if the club declines to pick up his $6.5 million option for 2014 and instead pays him a $300,000 buyout. Lopez is currently a free agent, and like Vogelsong, would hit the open market if he and the Giants haven't agreed to terms by 9 PT Monday, which would be the end of the Giants' exclusive negotiating window with both players. Both would remain available to re-sign with the Giants should they enter the open market.
The inaction with both 36-year-olds contrasts sharply with the club's approach to right fielder Hunter Pence and right-hander Tim Lincecum. The Giants agreed with Pence on a five-year, $90 million deal one day before the season ended. Lincecum was fully expected to gauge his value in free agency when he suddenly forged a two-year, $35 million agreement with San Francisco last week.
Vogelsong's agent, Dave Meier, has patiently awaited a call from the 415 area code.
"I haven't heard anything from the Giants, one way or the other," Meier said. "The ball's in their court. They control the destiny here."
Before the season began, Giants executives probably would have snatched up Vogelsong's option as if it were a coupon for free pizza. The right-hander posted a 27-16 record with a 3.05 ERA in 2011-2012, was the team's leading winner in the 2012 postseason (3-0) and captivated fans with his ascent from obscurity to glory. He endured a subpar 2013 season (4-6, 5.73), though he sustained a broken right hand when he was hit by a pitch on May 20 by Washington's Craig Stammen. Vogelsong also endured the physical erosion that struck almost every Giant who participated in the World Baseball Classic.
The Giants are expected to pursue a free-agent starting pitcher. But even if they sign one, they'd still need Vogelsong to complete a five-man contingent, unless they plan on obtaining two free-agent starters. Given the perennial Major League-wide hunger for starting pitching, the Giants likely would encounter challenging competition for Vogelsong's services if he became a free agent.
"Obviously, Ryan's first choice is to remain a San Francisco Giant," Meier said. "He loves the city, he loves the fans, he loves the coaches and he loves the ballclub."
Lopez expressed similar allegiance on numerous occasions this year. He demonstrated his loyalty to the Giants by quickly signing contract extensions when he was eligible for salary arbitration following the 2010 season and for free agency after 2011.
But Lopez, who earned $4.25 million this year, conceivably could command a more lucrative salary on the open market. No other left-handed reliever among potential free agents with more than 25 appearances matched Lopez's 1.83 ERA this season, though J.P. Howell (2.03) and Scott Downs (2.49) came close.


text:
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Guests of this hotel in Bentleyville can enjoy the Chippewa Golf Course, the Tanger Outlet Mall, and the Meadows Racetrack and Casino in nearby Washington. With our Bentleyville, PA hotel's close proximity to Pittsburgh, you're just thirty minutes away from Carnegie Science Center, Mt. Washington, Fallingwater, and other top attractions. Don't settle for lesser hotels in Bentleyville; reserve your room, at this Holiday Inn Express® hotel.
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When it comes to hotels in Bentleyville, ours is without a doubt the best, as our property boasts a myriad of amenities like free high-speed, wireless Internet access, an outdoor pool and a state-of-the-art Fitness Center. You can always expect the quality you deserve from the name you trust at our hotel in Bentleyville.
- Black-out Shades
- Rollaway Bed/Cot Available
- Crib Available
- Iron/Ironing Board
- Separate Hanging Closet
- In-Room Heating and A/C Controls
- Sofa Bed/Sleeper Couch
Bathroom/Personal Care
- Private Bathroom
- Bathroom Amenities Available
- Hair Dryer
- Bathtub
- Separate/Walk-in Shower
In-Room Features
- Mini Refrigerator
- Microwave
- Coffee Maker
- Flat-screen TV
- Work Desk with Lamp
- Desk-level Electrical Outlet
- Free Local Calls
- Cable/Satellite
- Premium Channels
- Stereo/Radio
- Phone with Voicemail
- Complimentary Morning Newspaper
Added Value
- Connecting Rooms Available
- Complimentary Coffee/Tea Supplies
- Full Breakfast Included
- Breakfast Buffet Included
- Continental Breakfast Included
- Complimentary Coffee in Lobby
Business Services
- 1 Meeting Room(s) Available
- On-Site Business Center
- Printer
- Copier
- Scanner
- Office supplies available
Internet Access
- Free High-Speed Internet in all Rooms
- Wireless Internet service is free for all IHG® Rewards Club members
Entertainment & Recreation
- Outdoor Pool
- Heated Outdoor Pool
- Outdoor Pool Hours of Operation: 8:00 AM - 10:00 PM
- Pool Open from: 27-May-2016 to 30-September-2016
Health & Fitness
Complimentary Fitness Center
We have: 1 treadmill 1 Elliptical 1 Bike Round Dumbells Bench Bosu Ball Exercise mat Stability ball Resistance band tubing
Hours of Operation: 12:00 AM to 11:50 PM
Fitness Center Type: LIMITED
Fitness Center Equipment:
- Treadmill
- Elliptical Machines
- Stationary Bicycle
Housekeeping & Laundry
- Daily Housekeeping
- On-site Guest Self-Laundry Facilities
- Hours of Operation: 12:00 AM - 11:59 PM
Added Value
- Executive Club Level
- Wake Up Calls
- Foreign Currency Exchange
- Ice Machine
Hotel Details
25 Smita Lane
Bentleyville, Pennsylvania 15314
United States
Check In: 3:00 PM
Check Out: 11:00 AM
Check-in Age: 21
Parking + -
- Complimentary Self Parking Available
Accessibility + -
- Public Entrance
- Guest Rooms
- Elevators
- Public Restrooms
- Registration Desk
- Exercise Facility
- Business Center
- Pool
- Number of Accessible Meeting Rooms: 2
Accessible Hotel Areas
- Registration Area
- Accessible Guest Rooms
- Business Center
- Meeting Room
- Exercise Facility
- Pool
Hotel Areas with Accessible Routes from Accessible Public Entrance
- Accessible Self Parking
- Van Accessible Self Parking
- Ramp Access
- Closed Caption TVs
- Visual Alarm/Alert in Guest Rooms
- Visual Alarm/Alert in Public Spaces
- Communication Kits with Visual Alarms
Provided by Hotel
Pet Policy + -
- Pets Allowed
- Service Animals Allowed
- Pet Walking Area On-site
- Pet Fee per Night: 25 USD
- A 25.00 non refundable fee per night will be charge to your room. We allow pets with a 50lb limit and a max of 2 pets per room. Pet must be attended at all times. Stains or damages left behind from a pet will result in a 250.00 non refundable fee.
Facility + -
- Smoke-Free Facility
- Number of Floors: 3
- Total Number of Rooms: 61
- Number of Non-Smoking Rooms: 61
- Number of Accessible Rooms: 6
- Connecting Rooms Available
Credit Cards + -
- American Express
- Visa
- MasterCard
- Diners Club
- Carte Blanche
- Discover


text:
Welcome to Cub Scout Pack 269!
The ten purposes of Cub Scouting are:
· Character Development
· Respectful Relationships
· Spiritual Growth
· Personal Achievement
· Good Citizenship
· Friendly Service
· Sportsmanship and Fitness
· Fun and Adventure
· Family Understanding
· Preparation for Boy Scouts
The Pack is comprised of five Dens:
Tiger Den – 1st grade Webelos 1 Den – 4th grade
Wolf Den – 2nd grade Webelos 2 Den – 5th grade
Bear Den – 3rd grade
The Pack (all 5 dens) meets once a month for a Pack Meeting. This is held at Parkmont Elementary School on the last Wednesday of the month from 7-8pm in the MUR room. At the Pack meeting, all family members are urged to participate. There are often crafts and games that siblings are encouraged to join. The boys may do skits or songs. Awards are handed out at the Pack meeting. The purpose of pack meetings is to inform everyone about upcoming events, recognize the boys hard work, entertain everyone and help the boys learn how to handle being in front of large groups.
Dens meet more often. Tigers meet once a month at 7pm on the 1st Wednesday of the month. Wolves, Bears, and Webelos 1 scouts meet twice a month on Wednesdays at 7pm. Webelos 2 scouts meet twice a month at 6:30pm on the 1st and 3rd Wednesday of every month. Den meetings are held at the MUR room at Parkmont Elementary School. Den meetings are both fun and educational. The activities they complete are recognized at the Pack meetings.
The calendar is packed with many things to do. As a pack we have a yearly overnight (this year we spent the night at the Aquarium of the Bay in San Francisco), a yearly camp out for families, a swim party, our pinewood derby model car races, a fishing derby, service projects, hikes, and more. We don't expect you to make them all. We understand that you have a life outside of Cub Scouts. In their dens, the boys work toward earning their "rank." They work on the 10 Cub Scouting ideals during this process. Each level has a different set of requirements. Some achievements are worked on at home, but mostly rank is earned through the den. Boys are encouraged to earn their rank but it is not required. They will graduate to the next level in June whether or not they earned their rank.
"Yes, extracurriculars do count in the admissions process. … Community service, part-time employment, forensics, Boy/Girl Scouts ... all tell us what you might be expected to 'share with your fellow classmates' should you enroll at our institution."
-- Daniel J. Saracino, Assistant Provost for Enrollment, University of Notre Dame


text:
No. 20 Bucknell fell behind early to No. 2 host Cornell in men's lacrosse Tuesday. But Chase Bailey scored the game-winner with one minute left to finish a second-half rally as the visiting Bison upset the Big Red, 9-8, in a game delayed by snow.
Sean Doyle led Bucknell (7-1) with three goals in its seventh straight win. Kyle Feeney made six saves for the Bison.
The Big Red (6-1) started strong, scoring the first five goals of the game. Bucknell netted five of the next six goals to trail 6-5 at halftime.
In a tightly contested second half, Doyle twice tied the game, first at 6 for the only goal of the third period and again at 7early in the fourth. He now has 17 goals on the year, giving him the third-most among the Bison.
Bucknell's season goal-scoring leader, Thomas Flibotte, gave the Bison their first lead of the game. Flibotte put the ball in the back of the net on an assist from Peter Burke to put Bucknell in front 8-7 with 7:14 to play. It was the freshman's second goal of the game after he also opened his team's scoring back in the second period.
Flibotte had two goals in the game. Joining him and Doyle with multiple goals was Bailey (2). Burke and Todd Heritage also had one apiece. David Dickson was responsible for three assists on the night, one of which led to Bailey's game-winner.
St. John's 7, No. 4 Hofstra 6: Kevin Cernuto completed his hat trick with four minutes left in the game to break a 6-all tie as the host Red Storm (5-2) upset the Pride (5-2).
Cernuto scored all his goals in the second half. St. John's has won two in a row; Hofstra's winning streak ended at four games.
No. 6 Syracuse 18, Providence 9: Henry Schoonmaker had three goals, and the visiting Orange (5-1, 2-0 Big East) won their fifth straight game. The Friars fell to 5-2, 0-2.
Syracuse led 11-2 at halftime.
No. 17 Penn State 11, Binghamton 7: The visiting Nittany Lions (4-3) went on a 6-0 run in the second quarter to pull away from the Bearcats (3-4).
Nick Dolik had three goals for Penn State, which has won its past two games. Nittany Lions goalie Austin Kaut recorded his second straight game with 16 saves.
State women
No. 12 Johns Hopkins 10, Towson 9: Freshman Dene' DiMartino scored with 2:41 to play to break a 9-9 tie and the visiting Blue Jays (6-2) bested the Tigers (1-6).
Hopkins, which has won three straight, improved to 12-8 over Towson.
Kelly Custer, Ashleigh Rohrback (Westminster) and Jackie LaMonica (Hereford) scored two goals each for the Tigers.
Washington College 15, Elizabethtown 10: Mollie Shipley had four goals and three assists to lead the host Shorewomen (6-0) past the Blue Jays (3-2).
Washington College took a 5-1 lead on a goal by Carly Eisenbrandt (Towson) with 17:01 left in the first half.
Elizabethtown scored the next two, but the Shorewomen scored three of the final four goals of the half for an 8-4 lead at the break.
Washington College kept the pressure up, scoring the first four goals of the second half.
Rowan 16, McDaniel 10: Danielle Entrot (Centennial) had six goals in a losing effort for the visiting Green Terror (4-2).
With the game tied at 6 at halftime, McDaniel's Anna Beaudry scored on a free-position goal 30 seconds into the second half. The Profs (3-3) answered 40 seconds later and started a 5-0 run.
National women
No. 2 Florida 22, Stetson 1: The host Gators (12-0) led by Hayley Katzenberger and Nora Barry with three goals each, outmuscled the Hatters (0-8).
No. 19 Rutgers 12, Princeton 10: Katrina Martinelli scored four goals, her seventh multi-goal effort of the season, and the host Scarlet Knights (7-1) are off to their best start in program history.
The Tigers fell to 3-2.
After trading goals in the first half, which ended in a 7-7 tie, Rutgers scored three of the final four in the second half to seal the win.
No. 15 Dartmouth 13, Davidson 12: Sarah Byrne scored the game-winner with 9:51 left, and the Big Green (5-2) used tough defense to weather a three-goal rally to win.
Latest College Lacrosse
Anna Fucigna (three goals) cut the Dartmouth lead to one with one second left for the Wildcats (2-5). Emily Cooke (Marriotts Ridge) led Davidson with three goals and three assists.


text:
Top 20 Jazz Discoveries of 2008
1. Pygmy Unit – Signals From Earth (Private, 1974)
An amazing free-jazz recording on par with Sun Ra's Strange Strings; just totally otherwordly. Features Darrell DeVore. Recorded in San Francisco and self-released.
2. Mary Lou Williams – Zoning (Mary, 1974)
Takes the piano and reimagines it as a power tool. Like nothing else Mary Lou Williams ever recorded. A pure product of the times, and also self-released.
3. Bill Barron – Modern Windows (Savoy, 1962)
Such an original voice on the tenor saxophone; also, Kenny Barron's brother. I heard this and I was transfixed immediately. Nothing else on Savoy sounds like this.
4. Terumasa Hino – Taro's Mood (Enja, 1973)
Whether sparse or pummeling, this record is in the moment from beginning to end. The total highlight of a batch of Japanese jazz LPs I came across earlier this year.
5. Leon's Creation – This is the Beginning (Studio 10, 1970)
San Francisco group that could have given Sly Stone a run for his money. Absolutely kills from beginning to end. Unbelievable grooves. Found in a 25-cent bin!
6. Boogaloo Joe Jones – No Way! (Prestige, 1971)
Funky jazz guitar that never goes out of style. For some reason I never liked Grant Green all that much, but this is incredible. Like a wild pet escaped from its cage.
7. Donna Brooks – I'll Take Romance (Dawn, 1956)
Basically a totally unknown singer who only made this one album. She captivates me.
8. Peter Brötzmann & Walter Perkins – The Ink is Gone (BRO, 2002)
Horns and drums skipping over the fires of hell. Wild sounds and intrinsic interplay. A more focused continuation of Machine Gun and Nipples.
9. Krczysztof Komeda – Cul-de-Sac (Harkit, 1966)
While digging around for Knife in the Water, I found this. It has its own sound. It grew on me, and it's completely unique. He died young.
10. Takehiro Honda – Jõdo (Trio, 1970)
Piano player from Japan who weirdly appears nude on the back cover. The title track alone is as suspenseful as a Hitchcock classic.
11. Lucy Ann Polk – With the Dave Pell Octet (Trend, 1954)
My favorite obscure female singer of the last two years. Wore out her LP on Mode, and finally got a copy of this session; it's breathtaking.
12. Mel Graves – Three Worlds (Arch, 1980)
Two days after he died, I came across this in the dollar bin. Had no idea it existed. Pretty out-there spiritual stuff, with George Marsh and Andy Narell.
13. Bennie Green – Soul Stirrin' (Blue Note, 1958)
There once was a time when people partied in the studio and called it an album.
14. Don Pullen – Solo Piano Album (Sackville, 1975)
"Unique" doesn't begin to describe this solo outing. Sadly overlooked. His playing always takes me on a mental journey.
15. Cecil Taylor – Love For Sale (United Artists, 1959)
Just an lesser-known LP from his late-'50s period that I hadn't heard of until this year. Half Cole Porter songs; half originals. Straddles reality and non-reality, respectively.
16. Jaki Byard – There'll Be Some Changes Made (Muse, 1972)
When I die I want Jaki Byard to come back to life and play at my funeral.
17. June Christy – The Cool School (Capitol, 1960)
I avoided this for years, thinking it was a soulless children's record. Instead, it swings like nothing else and fast became one of my favorites. The kids are alright.
18. Billy Butler – Guitar Soul! (Prestige, 1969)
More guitar jazz that actually creeps under the skin. "Blow for the Crossing" is a backbeat nightmare that belongs on every mixtape.
19. Paul Bley – Ballads (ECM, 1967)
I have a Paul Bley record on ESP which is blessed by heaven. Most everything else is okay, but I found this last week and it's in the clouds. Piano brilliance.
20. Melvin Jackson – Funky Skull (Limelight, 1969)
Standup bass, run through a fuzz box. Eddie Harris' right-hand man. A fun one.
Tags: 2008, Bill Barron, Boogaloo Joe Jones, Donna Brooks, Jazz albums, Leon's Creation, LP, Lucy Ann Polk, Mary Lou Williams, Peter Brotzmann, Pygmy Unit, Takehiro Honda, Terumasa Hino, Top


text:
Product 12/30
A powerful and capable telescope, the Orion SkyQuest XT8 Classic Dobsonian is one of our most popular models due to its elegant combination of precision optics, mechanical simplicity, and rock-solid stability. You and your whole family will appreciate the bright, clear views of the night sky provided by the XT8 Classic Dobsonian reflector. The Moon and planets of our solar system like Jupiter, Saturn, and Mars shine brightly in the SkyQuest XT8 Classic, allowing you to inspect them in detail. The XT8's 8" aperture is also large enough to gather a significant amount of light from more distant celestial objects for great views of sparkling star clusters, cloudy nebulas, and faraway galaxies. The XT8 Classic Dobsonian is a tremendous value considering the high quality views it provides on such a wide variety of celestial objects. The point-and-view simplicity of the Dobsonian design is not as complicated as a telescope attached to an equatorial (EQ) mount and tripod, so with a little practice, your whole family can scan the heavens just like experienced hobbyists. For any amateur astronomer seeking serious adventure, the XT8 Classic Dobsonian telescope has it all!
The SkyQuest XT8 Classic Dobsonian is built around an 8" (203mm) diameter parabolic primary mirror mounted in a cast-aluminum support cell. The mirror collects 78% more light than a 6" mirror, so you get a significant increase in ability to observe dust lanes in nebulas, resolve the cores of prominent globular star clusters, and to reveal some of the more subtle structures in faint galaxies. The 1200mm focal length (f/5.9) XT8 mirror allows you to obtain clear and crisp views at moderate to high magnifications on clear nights with good seeing conditions. Enhanced-reflectivity mirror coatings boost the XT8 Classic Dobsonian's mirror to 94% reflectivity so as much light as possible is transmitted to the eyepiece, for clear and bright views.
The Dobsonian base of the XT8 Classic provides a simple and stable low-profile altazimuth platform for the 8" aperture reflector optical tube. The tube attaches securely to the base by virtue of Orion's CorrecTension Friction Optimization system, which utilizes heavy-duty springs to both securely couple the tube to the base, and to keep the telescope in constant balance to avoid drifting during observations. Even with large 2" eyepieces and accessories installed, the XT8 Dobsonian telescope optical tube will remain balanced throughout your viewing sessions.
The SkyQuest XT8 Classic Dobsonian features a 2" Crayford-style focuser that accepts both 1.25" and 2" accessories. Focus adjustments are smooth, accurate, and virtually free of backlash and flexure, even with heavier 2" accessories installed.
The included 25mm Sirius Plossl eyepiece provides a 48-power magnification. You can expand your magnification options by purchasing additional 1.25" or larger 2" eyepieces of different focal lengths, sold separately.
An included Orion EZ Finder II reflex sight allows you to easily and accurately aim the 8" Classic Dobsonian. Also included are a quick collimation cap for easy mirror alignment, dust caps for the reflector telescope tube and focuser, and a special edition of Starry Night astronomy software and a SkyTheater DVD - a $69.90 value!
The Orion XT8 Classic Dobsonian telescope can conveniently be separated into two pieces for easy transport and storage. By unhooking the two CorrecTension springs from the Dobsonian base you can detach the 46.5" long optical tube. The XT8 reflector optical tube weighs 20.3 lbs., while the 19" diameter Dobsonian base tips the scales at 20.7 lbs. With an assembled weight of 41 lbs., the XT8 Classic Dobsonian can be easily moved to and from your favorite observing site, whether it's just a few steps out the back door, or many miles down the road.
A great telescope with the optical strength to please serious beginners and veteran skygazers alike, the Orion SkyQuest XT8 Classic Dobsonian reflector will provide years of astronomical adventure for you and your whole family.
Meets or exceeds all California State Environmental Quality & Safety Regulations (CARB 93120 Phase 2 Compliant).
This product was added to our catalog on Friday 14 December, 2012.


text:
Uehara dominant in early outings for Red Sox
TORONTO -- Perhaps not enough was made of the acquisition of reliever Koji Uehara during the offseason.
In his first two appearances with the Red Sox, Uehara has retired all six batters he has faced, throwing a total of 14 pitches.
After Felix Doubront opened the sixth by giving up a double on Friday night, Uehara struck out the next two batters and then got a flyout. He bounced off the mound with emotion.
"Well, he's going to be a one-inning guy," said manager John Farrell. "The number of pitches he's thrown has been about as minimal as you can get. The urge, or the tendency, is going to be to call his name all the time. He loves to compete. You see the energy he comes off the field with after completing an inning.
"Fortunately we've got the depth that we do, and the quality that we do. We'll have the ability to spread some things out and Koji will be a guy who will factor all those things."
The 38-year-old Uehara posted a 2.42 ERA for the Rangers last season.
"He did pitch on back-to-back days a few times last year, but we have to consider that, not taking anything away from him, but he's had a long career -- and a very successful one," said Farrell. "We've got to manage the physical side of that."


text:
The router object
Tony Bates
Mon Jul 18 17:27:38 CEST 1994
Please find below a draft of a proposal for a router object known as ``inet-rtr''. This is the missing link of the current ripe-81++ specifically for the ias-int information which was rightly removed along with the component attribute iself. This proposal is really a modification of a similar proposal made by Merit with just one or two clarifications and all credit belongs to them. This object could very quickly added to the Database. Please let me have comments asap. --Tony. Please note: a postscript version is available as ftp://ftp.ripe.net/ripe/drafts/inet-rtr.ps Specifying an `Internet Router' in the Routing Registry Tony Bates DRAFT - DRAFT - DRAFT Document ID: ripe-xy ABSTRACT This paper describes a simple specification for defining an Internet router within a routing registry. 1. Introduction It has become apparent as routing registries are evolving that there is a need to register some details of an Internet router (1) within the routing registry. By adding this kind of detailed information it adds functionality to information based on routing policies [1] facilitating the ability to build operational tools [2],[3] such as configuration generators and diagnostic tools within increased local information. It also provides a direct method to find a contact for an important component of the Internet infrastructure. This can be extremely useful when resolving operational problems. 2. Acknowledgments This specification is based on a similar specification by Merit Inc. for a `route' object (2). All credit should go to them. This paper acts purely to clarify the original ideas set out in the Merit paper. _________________________ (1) Here an Internet router means any IP [4] node ca- pable of running an IP routing protocol. Be that RIP, BGP or any other of the current IP based routing proto- cols found in the Internet today. This definition is intentionally looser than what might be found in the "Router requirements" Internet draft [5]. (2) This specification does not use `router' as the object name to avoid possible clashes with the `route' object which already exists within the routing regis- try. ripe-xy.txt July, 1994 - 2 - 3. Router Representation The representation must be capable of representing both ``interior'' and ``border'' routers within ones own autonomous system. Each object is uniquely identified by its object name. Here is a simple example of a router object: inet-rtr: Amsterdam.ripe.net localas: AS3333 ifaddr: 22.214.171.124 ifaddr: 220.127.116.11 ifaddr: 126.96.36.199 peer: 184.108.40.206 AS2122 BGP4 peer: 22.214.171.124 AS2122 BGP peer: 188.8.131.52 AS1104 BGP peer: 184.108.40.206 AS1103 BGP4 peer: 18.104.22.168 AS1103 BGP4 peer: 126.96.36.199 AS286 BGP4 peer: 22.214.171.124 AS3333 IBGP4 admin-c: Daniel Karrenberg tech-c: Tony Bates tech-c: Marten Terpstra notify: ops at ripe.net remarks: The router for the RIPE NCC changed: tony at ripe.net 940720 source: RIPE This object provides several key pieces of information. The exact syntax for each attribute is discussed in the next section. However, some general remarks about this example are worthy of note. From this you can see immediately that this router "Amsterdam.ripe.net" is in the autonomous system 3333 and has three configured inter- faces. You also see that it has several exterior peers and one inte- rior peer (22.214.171.124). Details of the actual routing protocol are given. This can be extremely useful. For example a BGP3 router is not CIDR [6] capable whereas a BGP4 capable router is. A tool could use this information when examining routing policy to see if a peer can make use of aggregation. Finally, we also see who we can con- tact when problems occur with this router. ripe-xy.txt July, 1994 - 3 - 4. `inet-rtr' Syntax Definition Here is a summary of the tags associated with inet-rtr object itself and their status. The first column specifies the attribute, the second column whether this attribute is mandatory in the inet-rtr object, and the third column whether this specific attribute can occur only once per object [single], or one or more [multiple]. When specifying multiple lines per attribute, the attribute name must be repeated. inet-rtr: [mandatory] [single] localas: [mandatory] [single] ifaddr: [mandatory] [multiple] peer: [optional] [multiple] tech-c: [mandatory] [multiple] admin-c: [mandatory] [multiple] remarks: [optional] [multiple] notify: [optional] [multiple] maintainer: [optional] [single] changed: [mandatory] [multiple] source: [mandatory] [single] Each attribute has the following syntax: inet-rtr: The fully qualified domain name of the router. Format: Fully qualified domain name without trailing "." (dot). This must be registered in the DNS. For routers with more than one DNS you should pick the one that seems most suit- able. It should be noted that it is commonly general prac- tice for a router to have single uniquely defined domain name. Example: inet-rtr: Amsterdam.ripe.net Status: mandatory, only one line allowed localas: The autonomous system in which this router belongs. Format: AS<positive integer between 1 and 65535> Example: localas: AS3333 Status: mandatory, only one line allowed ripe-xy.txt July, 1994 - 4 - ifaddr: An interface address within the router. Format: <Interface Address> [Local AS] <Interface Address> must be a "dotted-quad" represented host address. It should be noted that at ONE ifaddr must be configured for the inet-rtr object to be valid. This facilitates the registering of route servers which may only have one interface address and are purely routing engines. [Local AS] is an optional piece of information which allows this interface to be configured as being in a DIF- FERENT autonomous system. This is useful only when a router is configured to `fake' that it is another AS. The format of [Local AS] is AS<positive integer between 1 and 65535>. Examples: ifaddr: 126.96.36.199 ifaddr: 126.96.36.199 AS1755 Status: mandatory, multiple lines allowed peer: Details of any router peerings. These can be both interior or exterior. Format: <Peer address> <Peer AS> <Routing Protocol> <Peer address> is the interface address of the remote peer. This is same format as that used in the ``ifaddr'' attribute above. <Peer AS> is the autonomous system number of the peer. Its format is AS<positive integer between 1 and 65535>. It should be noted that even interior peers should have their <Peer AS> detailed. <Routing Protocol> represents the routing protocol running between the router and the peer. This can be any one of the following reserved routing protocol keywords: EGP The routers are using the exterior gateway protocol, EGP [7]. BGP The routers are using the exterior gateway protocol, BGP conforming to [8]. This can mean either BGP ripe-xy.txt July, 1994 - 5 - version 2 or BGP version 3. BGP4 The routers are using the exterior gateway protocol, BGP conforming to BGP version 4 [9]. IBGP The routers are using the exterior gateway protocol, BGP as an interior routing protocol conforming to [8]. This can mean either BGP version 2 or BGP ver- sion 3. IBGP4 The routers are using the exterior gateway protocol, BGP as an interior routing protocol conforming to BGP version 4 [9]. IDRP The routers are using the exterior gateway protocol, IDRP conforming to [10]. IGP This is an interior peering using a standard interior gateway protocol (i.e. RIP, OSPF, etc.). OTHER This peering is using a protocol not in one of the categories above. Example: peer: 126.96.36.199 AS2122 BGP4 peer: 220.127.116.11 AS2122 BGP peer: 184.108.40.206 AS1104 BGP peer: 220.127.116.11 AS1103 BGP4 peer: 184.108.40.206 AS1103 BGP4 peer: 184.108.40.206 AS286 BGP4 peer: 126.96.36.199 AS3333 IBGP4 Status: optional, multiple lines allowed admin-c: Full name or uniquely assigned NIC-handle of an administrative contact person. Format: <firstname> <initials> <lastname> or <nic-handle> Examples: admin-c: Joe T Bloggs admin-c: JTB1 Status: mandatory, multiple lines allowed ripe-xy.txt July, 1994 - 6 - tech-c: Full name or uniquely assigned NIC-handle of a technical con- tact person for this macro. This is someone to be contacted for technical problems such as misconfiguration. Format: <firstname> <initials> <lastname> or <nic-handle> Examples: tech-c: John E Doe tech-c: JED31 Status: mandatory, multiple lines allowed notify: The notify attribute contains an email address to which notifi- cations of changes to this object should be send. Format: <email-address> The <email-address> should be in RFC822 domain syntax wherever possible. Example: notify: Marten.Terpstra at ripe.net Status: optional, multiple lines allowed maintainer: The maintainer attribute contains a registered maintainer name. Format: <registered maintainer name> Example: maintainer: RIPE-DBM Status: optional, multiple lines allowed remarks: Remarks/comments, to be used only for clarification. Format: free text Example: remarks: This is a router ripe-xy.txt July, 1994 - 7 - Status: optional, multiple lines allowed changed: Who changed this object last, and when was this change made. Format: <email-address> YYMMDD <email-address> should be the address of the person who made the last change. YYMMDD denotes the date this change was made. Example: changed: johndoe at terabit-labs.nn 900401 Status: mandatory, multiple lines allowed source: Source of the information. This is used to separate information from different sources kept by the same database software. For RIPE database entries the value is fixed to RIPE. Format: RIPE Status: mandatory, only one line allowed ripe-xy.txt July, 1994 - 8 - 5. References [1] Bates, T., Gerich, E., Joncheray, L., Joanigot, J-M, Karren- berg, D., Terpstra, M, Yu, J., ripe-81++, July 1994. WORK IN PROGRESS [2] PRIDE Tools Release 1. See ftp.ripe.net:pride/tools/pride-tools-1.tar.Z. [3] Merit Inc. RRDB Tools. See rrdb.merit.edu:pub/meritrr/* [4] J. Postel, "Internet Protocol", RFC 791, January 1981. [5] Kastenholz, F., draft-ietf-rreq-iprouters-require-01.txt, April, 1994, INTERNET DRAFT [6] V. Fuller, T. Li, J. Yu, K. Varadhan, "Classless Inter-Domain Routing (CIDR): an Address Assignment and Aggregation Stra- tegy", RFC1519, Sep., 1993. [7] Mills, D., "Exterior Gateway Protocol formal specification", RFC904, April 1984. [8] K. Lougheed, Y. Rekhter, "A Border Gateway Protocol 3 (BGP-3)", RFC1267, October 1991. [9] Y. Rekhter, T. Li, "A Border Gateway Protocol 4 (BGP-4)", <draft-ietf-bgp-bgp4-10.txt>, INTERNET DRAFT, May, 1994. [10] C. Kunzinger, "ISO/IEC 10747 - Protocol for the Exchange of Inter-Domain Routing Information among Intermediate Systems to Support Forwarding of ISO 8473 PDUs", <draft-kunzinger-idrp- ISO10747-00.txt>, INTERNET DRAFT, April 1994. ripe-xy.txt July, 1994 -------- Logged at Mon Jul 18 18:03:35 MET DST 1994 ---------
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