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Huntsville Police Officer, William Darby was charged with the Murder of Jeffery Parker Friday.
According to Huntsville Police Department, Darby graduated from the Huntsville Police Academy in 2016.
He graduated with multiple awards including, being at the top of his class for his shooting accuracy.
Darby also won the overall award in every category in his graduating class, including academics and physical agility.
He also received the chief's award for having the highest ranking in all three categories.
This year Darby won the Billy Clardy Award for Community Policing, that's according to the Huntsville City Blog.
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text: jeppi26 1,854 Report post Posted February 13, 2016 Well after a long Wait a good brickie mate ad a free weekend to get a start on my pond after a week delay lol looking good up to now should be finished tomorrow fingers crossed if not net weekend. Can anyone recommend a good waterproof render for the inside of the pond it will be getting painted with rubber pond paint after rendered? 11 Quote Share this post Link to post Share on other sites

subset: commoncrawl


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The Final Call for Papers deadline has passed.
If you are listed as the author or co-author on a paper that has been accepted for presentation, please visit the Presenter Registration page. To register as an Audience member, please visit the Audience Registration page. Thank you.
"Independence & Interdependence"
October 31 – November 03, 2019 | Toshi Center Hotel, Tokyo, Japan
The 2019 conference theme for The 11th Asian Conference on Education is "Independence & Interdependence", and invites reflections on the desirability, extent and limits of our individual independence and autonomy, of that of our students, and of the institutions and structures within which we work, teach and learn. We do not educate, and are not educated in vacuums, but in such contexts and constraints as families, groups, and societies; of nations and cultures; of identities and religions; and of political and financial realities.
Ever changing technologies offer new ways for us to be independent and autonomous learners, encouraging students to be self-directed and confident in making choices, and enabling and empowering students and teachers to be proactive and tailor content. However, myriad technologies and services make us more dependent on the very things allowing autonomy. How do we help students and teachers alike navigate and curate the vast information available? How do we encourage individual growth while also underlining the importance of belonging and of the reciprocal responsibilities and privileges of education? How do we help students build the skills and attitudes necessary for positive engagement in distributed, globalised communities that so often lead to polarisation and alienation instead? How do we educate with independence and interdependence in mind?
This conference is organised by IAFOR in association with the IAFOR Research Centre at the Osaka School of International Public Policy (OSIPP) in Osaka University, Japan.
– The ACE2019 Organising Committee
Tien-Hui Chiang, Zhengzhou University, China
Joseph Haldane, The International Academic Forum (IAFOR), Japan
Tzu-Bin Lin, National Taiwan Normal University, Taiwan
Yvonne Masters, University of New England, Australia
José McClanahan, Creighton University, USA
Justin Sanders, Temple University, Japan Campus
Zachary Walker, University College London (UCL), UK
IAFOR Journal of Education (Scopus Indexed Journal)
This conference is associated with the Scopus and DOAJ listed IAFOR Journal of Education.
- Venue & Location: Toshi Center Hotel, Tokyo, Japan
- Dates: Thursday, October 31, 2019 to Sunday, November 03, 2019
- Conference Theme: ""Independence & Interdependence""
- Early Bird Abstract Submission Deadline: June 21, 2019*
- Final Abstract Submission Deadline: August 22, 2019
- Registration Deadline for Presenters: September 19, 2019
*Submit early to take advantage of the discounted registration rates. Learn more about our registration options.
Conference Outline*
16:30–18:00: Conference Registration
18:00-19:00: Welcome Reception
09:00–12:00: Plenary Session & Conference Photograph
12:00–13:15: Lunch Break
13:15–14:45: Parallel Sessions
14:45–15:00: Break
15:00–16:30: Parallel Sessions
16:30–17:30: Conference Poster Session
19:00-21:30: Official Conference Dinner (optional extra)
09:00–10:30: Parallel Sessions
10:30–10:45: Break
10:45–12:15: Parallel Sessions
12:15–13:15: Lunch Break
13:15–14:45: Parallel Sessions
14:45–15:00: Break
15:00–16:30: Parallel Sessions
16:30–17:00: Break
17:00–18:00: Parallel Sessions
09:00–10:30: Parallel Sessions
10:30–10:45: Break
10:45–12:15: Parallel Sessions
12:15–13:15: Lunch Break
13:15–14:45: Parallel Sessions
14:45–15:00: Break
15:00–16:30: Parallel Sessions
16:30–17:00: Break
17:00–18:00: Closing Session
The draft version of the Conference Programme will be available online on October 01, 2019. All registered delegates will be notified of this publication by email.
*Please be aware that the above schedule may be subject to change.
Organising Committee
The Organising Committee of The 11th Asian Conference on Education (ACE) is composed of distinguished academics who are experts in their fields. Organising Committee members may also be members of IAFOR's International Academic Advisory Board. The Organising Committee is responsible for nominating and vetting Keynote and Featured Speakers; developing the conference programme, including special workshops, panels, targeted sessions, and so forth; event outreach and promotion; recommending and attracting future Organising Committee members; working with IAFOR to select PhD students and early career academics for IAFOR-funded grants and scholarships; and overseeing the reviewing of abstracts submitted to the conference.
Review Committee
IAFOR's peer review process, which involves both reciprocal review and the use of Review Committees, is overseen by conference Organising Committee members under the guidance of the Academic Governing Board. Review Committee members are established academics who hold PhDs or other terminal degrees in their fields and who have previous peer review experience.
If you would like to apply to serve on the ACE2019 Review Committee, please visit our application page.


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THE ECHO'S campaign to Stop the Rot in some of Liverpool's most important landmarks was celebrating a major success with the first building being removed from our hit list.
St Peter's church in Seel Street has undergone major refurbishment with work outside almost complete and the design of the inside now underway.
Liverpool council leader Mike Storey said he believed it was now the right time to remove the building from the list in recognition of the work which has been done.
At the fourth meeting of the Stop the Rot forum yesterday, Cllr Storey asked for other buildings, including some outside the city centre, to be added to the hit list.
A decision on this will be made at the next meeting early in the New Year.
Just over a year ago the ECHO brought together some of the biggest names in the property world to try to save some of the city's most historic buildings from decay.
This came three months after the launch of our campaign to breathe new life into buildings which have become eyesores in the city centre.
Max Stone, from Frenson, who is involved in the regeneration of many city centre buildings, praised the efforts of the ECHO and its campaign.
Cllr Storey also voiced his support, adding: "The Stop the Rot Campaign has raised public awareness of what needs to be done in the city.
"The council now has additional resources in terms of money to enable us to tackle some of the problems which there are with buildings in Liverpool."
The Bishop of Liverpool, the Rt Rev James Jones, is the campaign's chairman.
He said the key to its success is "partnership."
He added: "I appeal, as chairman, for people to work together.
"Particularly in light of the Capital of Culture Bid, for those buildings which remain an eyesore, there needs to be a concerted effort by everyone to ensure that these buildings change."
Progress has been made on the majority of the 11 buildings on our hit list.
There were just three buildings where the owners could not report any changes being made.
Florence Institute, Dingle: PROGRESS>
MERSEYSIDE Building Preservation Trust has agreed to apply for funding for a feasibility study to be carried out on the building.
The Liverpool Architecture and Design Trust is considering taking over the institute as part of a building project for its apprentices.
It expects to make a decision on this by the end of November and will take between five and 10 years to refurbish the building.
Wellington Rooms, Mount Pleasant: NO CHANGE>
ABDUL Shaik, managing director of New Dimensions Properties, which owns the building was unable to attend the meeting.
Work has taken place to stop the dry rot and the building is stable.
The bishop raised concerns that no progress has been made on the building during the last two years apart from addressing the issues of damp.
Mike Burchnall, head of planning at Liverpool council, has agreed to meet with the owners to find out why work has not been carried out.
Stanley Buildings, Hanover Street: PROGRESS>
Owners Frenson have said as these buildings are at the centre of the Grosvenor Henderson scheme it is happy to pass over their ownership as soon as possible but this is something which is down to Grosvenor.
Grosvenor has said the buildings are top of its agenda to be looked at.
St Andrew's Church, Rodney Street: NO CHANGE>
THE owners have not complied with the repairs notices issued by the council and the next step is for a compulsory purchase order to be placed on the building.
The council is also considering issuing an urgent works notice on the building.
Owner Dr Amoolya Prasad claims the stonework of the building has to be cleaned before further work can take place.
Scandinavia hotel: NO CHANGE>
DOWNING Developments are the preferred developers for the building and has planning permission to transform it into luxury apartments, hotel, retail and leisure uses.
The bishop said around the table talks were urgently needed to establish who lease owner Jimmy Wong may have sold his interests to.
Duke Street terraces: PROGRESS>
THE buildings are structurally safe and have been re-roofed.
The owners, Frenson, claim further work has not taken place because they cannot foresee a commercial venture which would make work viable.
Frenson is concentrating on other developments in the city, but haspromised the buildings will never fall into disrepair again and will make changes in the next six months.
Former Post Office, Victoria Street: PROGRESS>
FUNDING is now being secured. Work is expected to start on site within the next six months.
Charles Hubbard, of Edmund Kirby, speaking on behalf of the owners, the Walton Group, said he is now "reasonably optimistic progress can at last be made."
60 Seel Street/30 Slater Street: PROGRESS>
MAX Stone, from Frenson, said buiding surveyors had agreed a programme or work to make the building safe and this was expected to take place in the next fortnight.
Mr Stone appealed for suggestions to be made as to how the building could be used in a commercial way.
Fleet Street warehouses: PROGRESS>
OWNERS Frenson has agreements to let the remainder of the building which is expected to be ready in November next year.
A tenant has already been secured for the main building.
Tobacco warehouse: PROGRESS>
THE north and south parts of the warehouse are most at risk.
Owners Kitgrove want to demolish the building and has confirmed they will apply for planning permission to do this if an owner is not found by the New Year. More than 300 companies across the world have shown an interest in saving the warehouse from demolition but Nigel Lee, planning officer at Liverpool council, says he does not know if any will be economically viable.
St Peter's: Success story for campaign
OFF THE LIST: St Peter's church on Seel Street>
THE fabric of the building is now secure. The exterior works are 85% complete and the design of the inside of the building is now being carried out.
This is an Urban Splash project which has previously received praise from ECHO Editor Mark Dickinson.
At the last meeting of the Stop the Rot Forum, Mr Dickinson congratulated Urban Splash for its work, saying: "They get on with it and get results. It is now up to other owners to follow the example."
Liverpool council leader Mike Storey told yesterday's forum: "There has been a mixed bag of successes and no action since we last met.
"News today that St Peter's church can now be removed from the Stop the Rot hit list is an important step forward. I hope we will be able to do this with many more buildings when we next meet.
"This is a significant building and shows what can achieved when people work together."


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What is Senbei?
Senbei are a traditional Japanese snack. Made from rice these crackers have been around for centuries. Being low in calories, they are a healthy snack option. They come in many different shapes and sizes, usually savory but sometimes also sweet. They go great with beer but can also be enjoyed with a cup of tea.


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Monday, July 22, 2013
5th Grade Language Notebook is Posted!!!
For those interested in the 5th grade notebook, here is what it looks like. Here is the link to the product in my TpT and TN stores.
Now, hopefully, I can blog about other things. :) I am looking forward to attending a blogger/TpT meet up with some of my fellow KY(and surrounding states) friends. I can't wait to post pictures and to tell you all about it.
Happy Monday!
4 comments:
Congratulations Nicole! We can all relate to how gratifying it is to finish a big project! I also want to congratulate you on being the #2 seller for grades 3-5 (and #3 seller for all grades) on TPT last week!! It's a well deserved reward for all your hard work - and your awesome products!ReplyDelete
Crafting Connections
Thank you so much, Deb! I appreciate you taking the time to leave this sweet comment. :)ReplyDelete
I like your products very much. You are one of the few people that I follow on teacherspayteachers.com. Your mind is blessed.ReplyDelete
I thought I would leave you a message and I see I'm not the first! I just feel so happy for you for all your success and wanted to say congratulations! Your work is so nice!
I wish you a nice restful break after hours of hard work (I know the feeling...I just posted about posture from working at the computer lol).
:) Shelley
The Perks of Teaching Primary


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Bento Box Challenge
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It's officially "Harry Potter Week" here in the Starving Chef's kitchen. Every year, my kitchen transfigures into...Read More
Crispy Skin Salmon Ramen Noodles
There's always an excuse to whip up some ramen. This artic-twist on a Japanese classic includes crispy skin salmon with...Read More


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Published by
Dispatches from Amagansett's Authors Night
Robert Caro stole my pen!
My silver kitten heels were sinking into the mud as I tried to make my way around the 14th Annual Authors Night event in Amagansett on Saturday.
I love reading but I was lost! This event, hosted by Alec Baldwin, "A Celebration of Books and 121 Years of Reading at the East Hampton Library", was going to take me 121 years just to get through.
Talk about slow going. It was literary chaos. So many people meandering around a muggy tent in the middle of a potato field in The Hamptons looking for stuff to read!
|This was like a Barnes and Noble in Jakarta at the height of monsoon season.
But we sweat-covered readers were there, I reminded myself, to actually meet the authors! To talk with them, to learn, to commune.
So I set off to meet some writers. There were so many to choose from- 85 in fact. I knew some of the more popular names: A.M. Homes, Lee Child, Dr. Ruth Westheimer, Jules Feiffer, Geraldo Rivera, Wednesday Martin and my boss, Michael Gross.
But I really wanted to meet Robert Caro.
The Powerbroker, his 1974 tome about Robert Moses, sits on my windowsill (and serves as a lounge chair for my cat). Collecting dust. Maybe if I talked to the two-time Pulitzer Prize winner, I could tackle the 1,336 pages?
But I had to find him first. The authors were supposed to be, as one would expect from a library-hosted event, seated in alphabetical order. However, Caro was not, as promised, between Lee Child and Marcia Butler.
I tried to leave the B-C section but it was nearly impossible to navigate around the impenetrable line of readers desperate to have Baldwin sign a copy of You Can't Spell America Without Me, so I changed directions.
The line for Dr. Ruth was shorter and interestingly mostly comprised of women. But now I was in the W-Z section. As I flipped through From You to Two: Dr. Ruth's Rules for Real Relationships, she told me how much she enjoys this event. "I love for people to look at my books, even if they don't buy them, I love for them to look." I both looked and bought.
|Another wrong turn landed me in the R's at Geraldo's table where he was autographing his memoir, The Geraldo Show.He told me that it "tracks my life and times from 911; it's my last professional chapter." He also said that he had to rewrite the book in July of 2016 because "my boss [Roger Ailes] got caught up in that sex harassment thing."
I trudged past Ndaba Mandela and David Margolick trying to make my way back to the head of the alphabet, thinking that perhaps I'd walked past Caro. But how could I have bypassed four volumes of Lyndon Johnson's life that he was no doubt signing for adoring fans?
I had a plan. Look for the tallest stack of books! It worked.
I found Caro's stand! But he wasn't there. A patient devotee pointed and said that the author had gone in search of a pen.
"Mr. Caro, Mr. Caro!" I yelled waving my Hello Kitty pen.
I offered to loan him my purple pen so that he wouldn't keep the growing line of autograph-seekers waiting, while I went in search of a more appropriate black one.
Pleased with myself, I muddled through more perspiring bookworms to a librarian-looking woman. After some grappling and the dropping of Caro's name, she surrendered her personal pen.
I cut to the head of the line of bibliophiles and presented Caro with the newly acquired pen! He took the Bic and began to sign the cover page of The Power Brokerfor an eager tweenager. He stopped. He looked at the Bic. He looked at me. He looked at my purple Hello Kitty pen.
"I prefer yours," said the bestselling author as he stole my pen back.
<< Back to Article List
|Copyright © 2009-2012. All Rights Reserved. Out of Work Designs


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The establishment of a police advisory committee in New Hartford is worth pursuing because it could be the public connection that was lost when the police commission was abolished last year.
Town Supervisor Patrick Tyksinski should pursue the plan because it's in the best interest of residents.
The police commission was created in the 1980s to de-politicize and bring professionalism to the force in the wake of a scandal known as "Code 31," a list of town officials and prominent Republicans whom police were told not to ticket. It led to the indictment of the town's then-supervisor, the ouster of its police chief and the dissolution of the town Police Department. The commission was created concurrently with the merger of the town and village police departments.
The commission was abolished in February 2010 after the town officials learned that it could make decisions without requiring town board approval. That didn't sit well with village officials, and they filed suit seeking to get the commission reinstated. The lawsuit was dismissed last October, and village attorney Gustave DeTraglia Jr. said officials will not take further legal action because they now agree with the town's decision.
It is the prerogative of the town supervisor to take control of police matters, and Tyksinski says that things have gone well since the commission was abolished. Be that as it may, a public connection to the police department is not a bad idea. While the proposed advisory committee wouldn't have the powers of the police commission, it would be an independent panel where residents could take their concerns; the panel could then make recommendations to the Town Board.
The panel should be a bipartisan mix, with appointments made by both village and town governments for a specified term. Any improved public access to government is a worthy mission.
Our view: New Hartford on right track with police advisers
The establishment of a police advisory committee in New Hartford is worth pursuing because it could be the public connection that was lost when the police commission was abolished last year.


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Summary of Picrorhiza kurroa
Primary Information, Benefits, Effects, and Important Facts
Picrorhiza kurroa is a herb from Ayurveda that is commonly called Kutki or Kutaki. It contains a 'bitter principle' which is a mixture of two molecules, the irioid glycosides known as picroside I and picroside II (picroside II also being called kutkoside) and the mixture overall is then called kutkin or picroliv. Overall, these are the active components.
The herb itself, due solely to the kutkin molecules, appears to be potently hepatoprotective (protective of the liver) when ingested prior to or taken after exposure to a toxin. The protective effects seem to extend to all tested toxins or stressors that are known to alter liver function, and appear to also extend to states of intrinsic liver dysfunction (viral hepatitis and NAFLD from a high fat diet). Most notably it is protective against Tylenol, alcohol, and the deathcap mushroom with a potency that is greater than silymarins (the active parts of milk thistle supplementation).
This fairly remarkable hepatoprotection from picrorhiza kurroa is limited by its lack of human studies, as despite the multitude of animal research on the topic there appears to only be one study in humans which showed that a very low dose of the supplement (25mg kutkin) was effective against viral hepatitis. Future studies in humans are needed to confirm its protective effects, and currently picrorhiza kurroa is a remarkably promising herb.
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Things To Know & Note
Is a Form Of
Primary Function:
Also Known As
Kutki, Picrorhiza scrophulariiflora, Katuki, Kurro, Kutkin, Picroliv, Picrolax
Caution NoticeExamine.com Medical Disclaimer
The plant picrorhiza kurroa may be endangered due to a mixture of its popularity and unregulated/unsustainable harvesting. Purchasing a product that specifically focuses on sustainability may be prudent
How to Take Picrorhiza kurroa
Recommended dosage, active amounts, other details
Supplementation of picroliv (picroside I plus picroside II) appears to be most effective in at 12mg/kg (the higher dose, 24mg/kg, is not significantly more effective than 12mg/kg in most cases) and this leads to a preliminary human dosage of:
130 mg for a 150lb person
170 mg for a 200lb person
220 mg for a 250lb person
Although the above dosage levels are ideal, lower doses also appear to be effective and the lone human study used a total picroside I and II dosage of around 25mg.
If using an extract of picrorhiza kurroa, then the above dosage refers to the total picroside I and II content (kutkin or picroliv) rather than the weight of the plant itself. For example, a plant extract that is 1,000 mg and contains 4% picroliv will confer 40 mg picroliv.
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects picrorhiza kurroa has on your body, and how strong these effects are.
|Level of Evidence [show legend]
|Robust research conducted with repeated double-blind clinical trials
|Multiple studies where at least two are double-blind and placebo controlled
|Single double-blind study or multiple cohort studies
|Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
|- See study
The one study using picrorhiza kurroa for the purpose of treating vitiligo noted that after daily usage that 27% of the subjects experienced complete resolution of symptoms (curative effect)
|- See study
Supplemental picrorhiza kurroa can reduce bilirubin in a model of acute viral hepatitis, although no comparisons to reference drugs have yet been made.
|- See study
Supplementation of picrorhiza kurroa is able to reduce circulating liver enzymes in acute viral hepatitis. While animal research suggests it is more potent than Milk thistle, the human evidence is not yet able to directly compare the two.
Studies Excluded from Consideration
Confounded with ginger and ginkgo biloba[1]
Confounded with other ayurvedic herbs[2]
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Research Breakdown on Picrorhiza kurroa
Click on any below to expand the corresponding section. Click on to collapse it.
Click here to fully expand all sections or here to fully collapse them.
Picrorhiza kurroa (of the family scrophulariaceae), also known as Kutki or Katuki, is a perennial herb used in Ayurveda and sometimes used as a substitute for the herb gentiana kurroo; and tends to grow in the Himilaya region on rocky places within 3000-5000m above sea level.[3] It is traditionally used for liver disorders, but has also been implicated in the treatment of upper respiratory tract, fevers, dyspepsia, chronic diarrhea, and scorpion stings[3] as a part of the formulations Arogyavardhini, Tiktadya ghrita, Jatyadi ghrita, Punarnavasava and Nimbadi churna.[4] It is sometimes used interchangeably with the similar herb Picrorhiza scrophulariiflora, which contains the same bioactives.[5]
The plant is also known to be highly bitter (white root moreso than black root) which led to its name (as picros is greek for 'bitter') and appears to be endangered due to overharvesting.[3] It should not be confused with picrotoxin, which is a completely different molecule that also happens to be better (hence the picros).
Picrorhiza kurroa is a bitter herb used in Indian medicine for the purpose of helping the liver and digestion, among other usages. It grows in a limited region and altitude, and is currrently overharvested to an endangered status
The bitter principle known as 'Kutkin',[6] which is a mixture of picroside I and picroside II (kutkoside).[4] These are irioid glycoside structures[7] present at 1.611% and 0.613% of the roots dry weight, respectively[5]
The α-methoxy substituted catechol Apocynin,[8] structurally similar to vanillic and ferulic acids
Cucurbitacin glycosides based on cucurbitacin B and dihydrocucurbitacin B[10]
The main ingredients are the two molecules that make up the mixture called kutkin (or picroliv), which are picroside I and picroside II; both molecules are based off the same backbone, but one contains a cinnamic acid group and the other an apocynin group.
Storage of picrorhiza kurroa at 50°C for three to six months appears to not result in any significant degradation, although storage at 60°C for this time frame resulted in a 30-50% rate of degradation.[11]
Higher than average temperatures may degrade the bioactives in the plant. While refrigeration does not appear to be necessary, it may be prudent to store it away from heat producing appliances
Picroliv is a mixture of kutkin (picroside I and picroside II) in a 1:1.5 ratio[12] which has a slightly higher concentration of picroside II than does basic kutkin (45:55).[4] 60% of the mixture by weight is picrosides I and II, with the other 40% being micellaneous irioid glycosides.[13]
Picroliv is another name for kutkin, and while kutkin tends to have a more balanced profile picroliv tends to favor a higher concentration of picroside II
Picrolax is a brand name for an extract of Picrorhiza kurroa which is recommended for laxative purposes. This extract appears to confer 45mg picroside I (0.02%) and 17.6mg picroside II (0.01%) for every 1.585g of supplement[4] suggesting that other bioactives play a more significant role.
Picrolax is a form of picrorhiza kurroa that is sold for its laxative purposes; it has a low concentration of kutkin but high enough doses may still be hepatoprotective
Irioid glycosides (picroside I and picroside II) are known to be able to be hydrolyzed in the intestines leading to their aglycones, as evidenced by aucubin.[14] This is hypothesized to partly underlie the poor oral bioavailability of picrosides[4] which is common among most irioid glycosides.[15][16][17] Isolated kutkin has a poorer bioavailability than does the plant extract however,[4] suggesting some synergism between components of the plant.
Like most irioid glycosides, the picrosides (components that make up kutkin) appear to be poorly absorbed. The exact bioavailability was not calculated
Following ingestion of Picrorhiza kurroa, picroside I has been detected in the blood at a Cmax of 206.10+/-7.09ng/mL (45mg/kg via 100mg/kg kutkin), a Cmax of 357.88+/-5.74ng/mL (same dose via 510mg/kg plant extract), and a Cmax of 301.43+/-9.19ng/mL (same dose via 1.585g/kg picrolax).[4] All Tmax values were approximately one hour, and the half-life was 50-56m for mixtures and 37m for pure kutkin.[4]
Following ingestion of Picrorhiza kurroa, picroside II has been detected in the blood at a Cmax of 152.62+/-11.54ng/mL (55mg/kg picroside II via 100mg/kg kutkin), a Cmax of 134.67+/-18.18ng/mL (32.3mg/kg via 510mg/kg plant extract), and a Cmax of 76.64+/-3.69ng/mL (17.6mg/kg via 1.585g/kg picrolax).[4] Picroside II also has a Tmax of approximately one hour, but a shorter half-life between 15-30m.[4]
Picrosides reach serum at a low nanomolar concentration
Picroside II appears to be predominately (80%) conjugated in the blood as either a glucoronide or sulfate, with 20% of circulating picroside II being eliminated in its free form.[18]
Picrosides appear to be conjugated by Phase II metabolic enzymes
In mice given a high fat diet, 50-200mg/kg of picrorhiza kuroa daily for 12 weeks appears to be able to normalize most parameters of lipid metabolism (triglycerides, cholesterol, LDL-C) although without apparent influence on HDL-C; these changes were thought to be secondary to aiding the liver[19] and has been seen elsewhere with lipid alterations induced by PX-407.[20]
Secondary to helping the liver, there may be reductions in circulating triglycerides and LDL cholesterol
100-200mg/kg of a water extract of picrorhiza kurroa over the course of 14 days in diabetic rats (streptozotocin induced) is able to improve blood glucose and insulin levels in a dose-dependent manner, with the 200mg/kg dosage being nonsignificantly less potent than the reference drug of 10mg/kg glibenclamide.[21]
There may be antidiabetic properties of the plant, but they are mostly unexplored and trend to underperform relative to the reference drug glibenclamide
Apocynin appears to be able to inhibit NADPH oxidase in neutrophils in vitro at 4µg/mL concentration, with a potency somewhat comparable to 20µg/mL vanillic and ferulic acids[22] and appears to be effective in microglia at 500µM.[23]
Oral ingestion of apocynin at 100mg/kg thrice daily alongside MPTP toxin (to induce parkinson's like effects via microglia activation) was able to alleviate symptoms, which was attributed to NADPH oxidase inhibition.[8] NADPH oxidase activation is known to be involved in the pathology of MPTP[23] and protective effects have been noted with other NADPH oxidase inhibitors such as Spirulina.[24]
Apocynin appears to be an NADPH oxidase inhibitor, albeit significantly weaker than the reference supplement (C-phycocyanobilin from spirulina)
200mg/kg of the rhizome of kutki for 14 days prior to immunosuppression (cyclophosphamide) is able to partly preserve the reduction in antibody titer seen in immunosuppressed control and slightly increased antibodies in control mice.[25]
There appears to be an increase in antibodies in mice given oral supplementation of the plant, and this may occur with and without immunosuppression
A phenolic glycoside known as androsin found in picrohiza kurroa appears to be able to reduce allergic reactions at an oral dose of 10mg/kg in guinea pigs an hour prior to inhalation challenge[9] or 500µg inhalative.[26]
One study using a combination supplement of picrorhiza kurroa (270mg of 30% apocynin), ginger (100mg of 5% gingerols), and ginkgo biloba (130mg of 24% ginkgoflavones) taken twice daily for 20 weeks failed to note any significant benefit on Peak Expiratory Flow Rate (PEF) or FEV1 and only trends to improve asthmatic symptoms.[1]
No significant known interactions with asthma
An ayurvedic mixture of herbs (Arogya-wardhani) of which is 50% picrorhiza kurroa by weight has been noted to have efficacy against acute viral hepatitis[27] and when 375mg of picrorhiza kurroa thrice daily for two weeks (daily dose of 8.16-8.64mg picroside I and 16.5-18mg picroside II) was able to reduce serum bilirubin and enzymes in a time dependent manner.[11]
The lone human study noted that the well known hepatoprotective effects applied to humans with acute viral hepatitis over the course of two weeks of supplementation
Picroliv (25mg/kg) orally to rats for six weeks effectively abolished (over 90% normalization) the changes induced by aflatoxin despite not having a significant effect on rats not given aflatoxin[28] and this potency against aflatoxin specifically has been replicated elsewhere with comparable potency to 20mg/kg silymarin (from milk thistle, comparable molar doses) although the 84-100% protection seen with picroliv was less variable than silymarin (53-100%) and while silymarin was more effective at reducing lipid peroxidation picroliv is more effective at reducing liver enzymes (GPT and ALP).[29][13] Picroliv appears to be effective when given prior to the toxin[28] and when given after toxin exposure for one week,[30] two weeks,[13] and six weeks.[29]
Although most studies assess the protective effects of picroliv against aflatoxin it has also shown protective effects against oxytetracycline (at 1.2-12mg/kg picrolive),[31] carbon tetrachloride (12mg/kg picroliv),[32][33] thioacetamide,[34] paracetamol,[35][36] cadmium,[37][38] ischemia[39] and partial hepatectomy,[40] monocrotaline,[41] hydrazine,[42] galactosamine (12mg/kg picroliv),[43][11] and alcohol.[44] Most notably, picroliv also appears to be protective against poisoning from the deathcap mushroom (Amanita phalloides) with protective effects comparable to silybinin yet greater rehabilitative effects.[45]
When looking at the studies on alcohol specifically when thirty days of alcohol ingestion (3.76g/kg in rats) was followed up with coingestion of alcohol and 12mg/kg picroliv for 15 days, picroliv was able to attenuate the adverse changes (although not absolute protection)[44] although 45 days of continuous ingestion at 12mg/kg caused full protection (3mg/kg causing 36% protection).[46]
Picroliv (picrosides I and II) appears to be very potently protective of the liver in rats, in accordance with its claims in ayurvedic medicine. The protective effects seem to extend to pretty much every liver stressor tested, and seems to persist when taken either in a prophylactic (preventative) or rehabilitative manner
In general, when picroliv is used at the higher dosage (25mg/kg oral ingestion) and compared to an equimolar dosage of silymarin (20mg/kg) they are comparable in protective effects[29][13] but when lower doses of picroliv (12.5mg/kg or less) are compared against an equimolar dose of silymarin (10mg/kg or less) picroliv appears to be more potent.[31] Doses in the 50-100mg/kg range for picroliv are still comparable to equimolar doses of silymarin, and is also comparable to curcumin and ellagic acid.[33][35]
When compared to other hepatoprotective agents, picroliv appears to be as potent as silymarins (from milk thistle) when they are compared at higher doses and stronger when they are compared at lower doses
Picroliv possesses chloretic and anticholestatic potential in rats treated with paracetamol and ethynyl estradiol,[36] CCl4,[47] alcohol,[46] and cadium.[37][38] In this regard, supplementation of 3-6mg/kg to rats is effective yet there markers of cholestasis are fully normalized with prolonged ingestion (2 weeks or longer) of 12mg/kg picroliv[47][46] and seems more potent than an equimolar dose of silymarins.[36]
There appears to be an anticholestatic potential for picroliv in instances of liver damage which is maximized (absolute protection) at a chronic rat intake of 12mg/kg. This potency exceeds silymarins from milk thistle
When looking at fatty liver (steatohepatitis) in rats fed a high fat diet, 200-400mg/kg of a 50:50 ethyl alcohol:water picrorhiza kurroa extract (6.54% picrosides) is able to significantly reduce liver fat over the course of four weeks supplementation, with the higher dose having a greater potency than 50mg/kg silymarins.[48] The increase in liver fat from changing to a high fat diet in rats was fully prevented, and the picrorhiza kurroa group ended up with 42% the liver fat seen in the control group.[48]
Steatohepatitis induced by hydrazine is also prevented with supplementation of picrosides at 50mg/kg.[42]
The liver protective effects seem to extend to reducing fatty liver, where picrorhiza kurroa seems very effective at preventing fatty liver (its benefits also seem general rather than specific for a particular cause of fatty liver)
In inflammatory bowel diseases (ulcerative colitis), the release of inflammatory cytokines such as IL-1β and TNF-α are involved in pathology[49][50] and suppressing their release via inhibiting NF-kB is seen as therapeutic.[51][52]
In a mouse model of dextran-sulfate-sodium (DSS) induced colitis, supplementation of 12.5mg/kg picroliv for seven days following DSS ingestion (for seven days prior to picroliv and continued throughout supplementation) was able to attenuate the reduction in colon length and improve histological scores by about half.[12] These benefits correlated with less NF-kB mRNA induction and less release of inflammatory cytokines (IL-1β and TNF-α) and oxidation.[12]
Appears to have moderately potent antiinflammatory effects in an animal model of ulcerative colitis
The alterations seen in kidney oxidative markers from aflatoxin are potently suppressed with ingestion of 25mg/kg picroliv in rats for 14 days after aflatoxin ingestion, with a potency somewhat comparable to 20mg/kg silymarin.[13] When comparing the protective effects in the liver against the protective effects in the kidneys, picroliv seems slightly more effective in protecting the liver (in a model of cadmium toxicity).[38]
The liver protective effects may also extend to the kidneys, suggesting a general protective effect against organ function
- ^ a b Thomas M, et al. AKL1, a botanical mixture for the treatment of asthma: a randomised, double-blind, placebo-controlled, cross-over study. BMC Pulm Med. (2007)
- ^ Keche Y, Badar V, Hardas M. Efficacy and safety of livwin (polyherbal formulation) in patients with acute viral hepatitis: A randomized double-blind placebo-controlled clinical trial. Int J Ayurveda Res. (2010)
- ^ a b c [No authors listed. Picrorhiza kurroa. Monograph. Altern Med Rev. (2001)
- ^ a b c d e f g h i j Upadhyay D, et al. Comparative pharmacokinetic profiles of picrosides I and II from kutkin, Picrorhiza kurroa extract and its formulation in rats. Fitoterapia. (2013)
- ^ a b Tiwari SS, et al. TLC densitometric quantification of picrosides (picroside-I and picroside-II) in Picrorhiza kurroa and its substitute Picrorhiza scrophulariiflora and their antioxidant studies. Biomed Chromatogr. (2012)
- ^ Basu K, Dasgupta B, Ghosal S. Structure of kutkin, the bitter glucoside of Picrorhiza kurroa Royle ex Benth. J Org Chem. (1970)
- ^ Kumar V, et al. A Proposed Biosynthetic Pathway of Picrosides Linked through the Detection of Biochemical Intermediates in the Endangered Medicinal Herb Picrorhiza kurroa. Phytochem Anal. (2013)
- ^ a b Philippens IH, et al. Oral treatment with the NADPH oxidase antagonist apocynin mitigates clinical and pathological features of parkinsonism in the MPTP marmoset model. J Neuroimmune Pharmacol. (2013)
- ^ a b Dorsch W, et al. Antiasthmatic effects of Picrorhiza kurroa: androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigs. Int Arch Allergy Appl Immunol. (1991)
- ^ Stuppner H, Wagner H. New cucurbitacin glycosides from Picrorhiza kurrooa. Planta Med. (1989)
- ^ a b c Vaidya AB, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studies. J Postgrad Med. (1996)
- ^ a b c Zhang DK, et al. A Picrorhiza kurroa derivative, picroliv, attenuates the development of dextran-sulfate-sodium-induced colitis in mice. Mediators Inflamm. (2012)
- ^ a b c d e Rastogi R, Srivastava AK, Rastogi AK. Long term effect of aflatoxin B(1) on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin. Phytother Res. (2001)
- ^ Transformation of aucubin to new pyridine monoterpene alkaloids, aucubinines A and B, by human intestinal bacteria.
- ^ Wang CH, et al. Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice. Eur J Drug Metab Pharmacokinet. (2004)
- ^ Park EJ, et al. Pharmacokinetics of verproside after intravenous and oral administration in rats. Arch Pharm Res. (2009)
- ^ Li HL, et al. Determination of the plasma pharmacokinetic and tissue distributions of swertiamarin in rats by liquid chromatography with tandem mass spectrometry. Arzneimittelforschung. (2012)
- ^ Li T, et al. Assessment of UDP-glucuronosyltransferase catalyzed formation of Picroside II glucuronide in microsomes of different species and recombinant UGTs. Xenobiotica. (2011)
- ^ Lee HS, Yoo CB, Ku SK. Hypolipemic effect of water extracts of Picrorrhiza kurroa in high fat diet treated mouse. Fitoterapia. (2006)
- ^ Lee HS, Ahn HC, Ku SK. Hypolipemic effect of water extracts of Picrorrhiza rhizoma in PX-407 induced hyperlipemic ICR mouse model with hepatoprotective effects: a prevention study. J Ethnopharmacol. (2006)
- ^ Husain GM, Singh PN, Kumar V. Antidiabetic activity of standardized extract of Picrorhiza kurroa in rat model of NIDDM. Drug Discov Ther. (2009)
- ^ Simons JM, et al. Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils. Free Radic Biol Med. (1990)
- ^ a b Gao HM, et al. Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease. FASEB J. (2003)
- ^ Chamorro G, et al. Spirulina maxima pretreatment partially protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Nutr Neurosci. (2006)
- ^ Hussain A, et al. Protective effects of Picrorhiza kurroa on cyclophosphamide-induced immunosuppression in mice. Pharmacognosy Res. (2013)
- ^ Dorsch W, Wagner H. New antiasthmatic drugs from traditional medicine. Int Arch Allergy Appl Immunol. (1991)
- ^ Antarkar DS, et al. A double-blind clinical trial of Arogya-wardhani--an ayurvedic drug--in acute viral hepatitis. Indian J Med Res. (1980)
- ^ a b Rastogi R, Srivastava AK, Rastogi AK. Biochemical changes induced in liver and serum of aflatoxin B1-treated male wistar rats: preventive effect of picroliv. Pharmacol Toxicol. (2001)
- ^ a b c Rastogi R, et al. Hepatocurative effect of picroliv and silymarin against aflatoxin B1 induced hepatotoxicity in rats. Planta Med. (2000)
- ^ Dwivedi Y, et al. Picroliv protects against aflatoxin B1 acute hepatotoxicity in rats. Pharmacol Res. (1993)
- ^ a b Saraswat B, et al. Protective effect of picroliv, active constituent of Picrorhiza kurrooa, against oxytetracycline induced hepatic damage. Indian J Exp Biol. (1997)
- ^ Santra A, et al. Prevention of carbon tetrachloride-induced hepatic injury in mice by Picrorhiza kurrooa. Indian J Gastroenterol. (1998)
- ^ a b Girish C, Pradhan SC. Hepatoprotective activities of picroliv, curcumin, and ellagic acid compared to silymarin on carbon-tetrachloride-induced liver toxicity in mice. J Pharmacol Pharmacother. (2012)
- ^ Dwivedi Y, et al. Picroliv affords protection against thioacetamide-induced hepatic damage in rats. Planta Med. (1991)
- ^ a b Girish C, et al. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam Clin Pharmacol. (2009)
- ^ a b c Shukla B, et al. Choleretic effect of picroliv, the hepatoprotective principle of Picrorhiza kurroa. Planta Med. (1991)
- ^ a b Yadav N, Khandelwal S. Effect of Picroliv on cadmium-induced hepatic and renal damage in the rat. Hum Exp Toxicol. (2006)
- ^ a b c Yadav N, Khandelwal S. Therapeutic efficacy of Picroliv in chronic cadmium toxicity. Food Chem Toxicol. (2009)
- ^ Singh AK, et al. Picroliv preconditioning protects the rat liver against ischemia-reperfusion injury. Eur J Pharmacol. (2000)
- ^ Effect of picroliv on antioxidant-system in liver of rats, after partial hepatectomy.
- ^ Dwivedi Y, et al. Picroliv protects against monocrotaline-induced hepatic damage in rats. Pharmacol Res. (1991)
- ^ a b Vivekanandan P, et al. Protective effect of picroliv against hydrazine-induced hyperlipidemia and hepatic steatosis in rats. Drug Chem Toxicol. (2007)
- ^ Dwivedi Y, et al. Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats. Pharmacol Toxicol. (1992)
- ^ a b Rastogi R, et al. Picroliv protects against alcohol-induced chronic hepatotoxicity in rats. Planta Med. (1996)
- ^ Floersheim GL, et al. Protection against Amanita phalloides by the iridoid glycoside mixture of Picrorhiza kurroa (kutkin). Agents Actions. (1990)
- ^ a b c Saraswat B, et al. Ex vivo and in vivo investigations of picroliv from Picrorhiza kurroa in an alcohol intoxication model in rats. J Ethnopharmacol. (1999)
- ^ a b Saraswat B, et al. Anticholestatic effect of picroliv, active hepatoprotective principle of Picrorhiza kurrooa, against carbon tetrachloride induced cholestasis. Indian J Exp Biol. (1993)
- ^ a b Shetty SN, et al. A study of standardized extracts of Picrorhiza kurroa Royle ex Benth in experimental nonalcoholic fatty liver disease. J Ayurveda Integr Med. (2010)
- ^ Rogler G, Andus T. Cytokines in inflammatory bowel disease. World J Surg. (1998)
- ^ Ogata H, Hibi T. Cytokine and anti-cytokine therapies for inflammatory bowel disease. Curr Pharm Des. (2003)
- ^ Xiang JY, et al. Amelioration of murine dextran sulfate sodium-induced colitis by nuclear factor-kappaB decoy oligonucleotides. Am J Surg. (2009)
- ^ Jobin C, Sartor RB. NF-kappaB signaling proteins as therapeutic targets for inflammatory bowel diseases. Inflamm Bowel Dis. (2000)
- ^ Yadav N, Khandelwal S. Effect of Picroliv on cadmium induced testicular damage in rat. Food Chem Toxicol. (2008)
- ^ Yadav N, et al. Prevention of acute cadmium toxicity by Picroliv. Hum Exp Toxicol. (2005)
- ^ Bedi KL, et al. Picrorhiza kurroa, an ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Ethnopharmacol. (1989)


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Revision 23 for 'Brain development'All Revisions - View changeset
Brain development
Brain development occurs from the three vesicles of the embryo's neural tube.
- prosencephalon/forebrain
- mesencephalon/midbrain
- rhombencephalon/hindbrain
By approximately 4.5 to 5 menstrual weeks, the primitive neural plate has developed. The neural plate then divides into the neural crest and the neural tube. The neural tube differentiates into the primitive brain and the spinal cord.
At about 7 to 8 menstrual weeks, the primary vesicles of the brain are formed and can be recognized with endovaginal sonography.
The forebrain further separates into the telencephalon (cerebrum) and diencephalon (thalamus and related structures).
The midbrain links the diencephalon and telecephalon to the rest of the brainstem.
The hindbrain further divides into the metencephalon (pons and cerebellum) and myelencephalon (medulla oblongata)


text:
L Brands Takes Action to Increase Shareholder Value – Announces 2019 Closure of Henri Bendel Stores and Henri Bendel E-Commerce
/EIN News/ -- COLUMBUS, Ohio, Sept. 13, 2018 (GLOBE NEWSWIRE) -- With a focus on increasing shareholder value, L Brands, Inc. (NYSE: LB) announces the January 2019 closing of all 23 Henri Bendel stores and the Henri Bendel e-commerce website. The stores include the company's Fifth Avenue store as well as smaller-format stores in 11 states.
All stores and the website will remain in operation through January 2019 with new merchandise continuing to arrive through the holiday season.
"We are committed to improving performance in the business and increasing shareholder value. As part of that effort, we have decided to stop operating Bendel to improve company profitability and focus on our larger brands that have greater growth potential," said Leslie Wexner, chairman and CEO of L Brands. "This decision is right for the future growth of our company, but not easy because of the impact to our L Brands family. I want to thank our Bendel associates for their dedication to this iconic brand and to our loyal Bendel customers."
The associates staying with the business through January will be offered retention bonuses. At the point when associates' positions are eliminated, they will be invited to interview for open positions within the company or will be offered separation pay and job search support services.
Operating results for Henri Bendel are included in the company's Other segment for financial reporting. The company estimates that Henri Bendel 2018 revenues and operating loss, excluding closing costs, will be approximately $85 million and $45 million, respectively. The company is in the process of estimating the costs associated with closing the business.
L Brands, through Victoria's Secret, PINK, Bath & Body Works, La Senza and Henri Bendel, is an international company. The company operates 3,084 company-owned specialty stores in the United States, Canada, the United Kingdom and Greater China, and its brands are sold in more than 800 additional franchised locations worldwide. The company's products are also available online at www.VictoriasSecret.com, www.BathandBodyWorks.com, www.HenriBendel.com and www.LaSenza.com.
Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995
We caution that any forward-looking statements (as such term is defined in the Private Securities Litigation Reform Act of 1995) contained in this press release or made by our company or our management involve risks and uncertainties and are subject to change based on various factors, many of which are beyond our control. Accordingly, our future performance and financial results may differ materially from those expressed or implied in any such forward-looking statements. Words such as "estimate," "project," "plan," "believe," "expect," "anticipate," "intend," "planned," "potential" and any similar expressions may identify forward-looking statements. Risks associated with the following factors, among others, in some cases have affected and in the future could affect our financial performance and actual results and could cause actual results to differ materially from those expressed or implied in any forward-looking statements included in this press release or otherwise made by our company or our management:
- general economic conditions, consumer confidence, consumer spending patterns and market disruptions including severe weather conditions, natural disasters, health hazards, terrorist activities, financial crises, political crises or other major events, or the prospect of these events;
- the seasonality of our business;
- the dependence on mall traffic and the availability of suitable store locations on appropriate terms;
- our ability to grow through new store openings and existing store remodels and expansions;
- our ability to successfully expand internationally and related risks;
- our independent franchise, license and wholesale partners;
- our direct channel businesses;
- our ability to protect our reputation and our brand images;
- our ability to attract customers with marketing, advertising and promotional programs;
- our ability to protect our trade names, trademarks and patents;
- the highly competitive nature of the retail industry and the segments in which we operate;
- consumer acceptance of our products and our ability to manage the life cycle of our brands, keep up with fashion trends, develop new merchandise and launch new product lines successfully;
- our ability to source, distribute and sell goods and materials on a global basis, including risks related to:
- political instability, significant health hazards, environmental hazards or natural disasters;
- duties, taxes and other charges;
- legal and regulatory matters;
- volatility in currency exchange rates;
- local business practices and political issues;
- potential delays or disruptions in shipping and transportation and related pricing impacts;
- disruption due to labor disputes; and
- changing expectations regarding product safety due to new legislation;
- our geographic concentration of vendor and distribution facilities in central Ohio;
- fluctuations in foreign currency exchange rates;
- stock price volatility;
- our ability to pay dividends and related effects;
- our ability to maintain our credit rating;
- our ability to service or refinance our debt;
- our ability to retain key personnel;
- our ability to attract, develop and retain qualified associates and manage labor-related costs;
- the ability of our vendors to deliver products in a timely manner, meet quality standards and comply with applicable laws and regulations;
- fluctuations in product input costs;
- our ability to adequately protect our assets from loss and theft;
- fluctuations in energy costs;
- increases in the costs of mailing, paper and printing;
- claims arising from our self-insurance;
- our ability to implement and maintain information technology systems and to protect associated data;
- our ability to maintain the security of customer, associate, third-party or company information;
- our ability to comply with regulatory requirements;
- legal and compliance matters; and
- tax, trade and other regulatory matters.
We are not under any obligation and do not intend to make publicly available any update or other revisions to any of the forward-looking statements contained in this press release to reflect circumstances existing after the date of this press release or to reflect the occurrence of future events even if experience or future events make it clear that any expected results expressed or implied by those forward-looking statements will not be realized. Additional information regarding these and other factors can be found in Item 1A. Risk Factors in our 2017 Annual Report on Form 10-K.
|For further information, please contact:
|L Brands:
|Investor Relations
|Media Relations
|Amie Preston
|Tammy Roberts Myers
|(614) 415-6704
|(614) 415-7072
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You've got out a plan to visit Dubai and have decided what to see and what to do. But do you know when is the best season to visit Dubai so you can really enjoy your time here? I try to cover some of the most asked questions on every tourist's mind about the best time to visit Dubai. Continue reading "Dubai Travel Guide: Best Season to Visit Dubai"
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10 Things to do in Ahmedabad: Local Sightseeing
Ahmedabad is located in Gujarat, a western state of India and famous for textile trading. While it's not usually on the list of places to visit in India, it sure is a great place to visit underrated tourist attractions and indulge in street food! If you are planning a trip to India and would like to visit a new state, here are 10 things to do for your Ahmedabad local sightseeing tour. Continue reading "10 Things to do in Ahmedabad: Local Sightseeing"
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Sydney Itinerary 3 Days: Places to Visit in Sydney
One of the most attractive cities in the world, Sydney in Australia is the capital of the state of New South Wales. It is the most populated city in Australia and, while expensive, has been rated one of the most livable cities in the world.
Continue reading "Sydney Itinerary 3 Days: Places to Visit in Sydney"
The Ultimate Abu Dhabi Guide for 2020
Abu Dhabi has often been overlooked by most visitors to the United Arab Emirates. Even so by locals in the country as most Abu Dhabi residents usually travel to Dubai to spend their holidays. However, a recent trip to my sister's place there made me fall in love with the emirate! If you're a resident or just a tourist looking to visit the United Arab Emirates, here is a useful Abu Dhabi guide on how to spend your holiday in Abu Dhabi.
Budget Bangkok Itinerary: 4 Days for First Timers
After being back from the holidays, and visiting some great Bangkok tourist spots, I have compiled a budget Bangkok itinerary, 4 days of exploring the city for anyone traveling to Thailand to experience the food, culture, and attractions.
This Bangkok 4 day itinerary has all the details for the best area to stay in Bangkok, places to see, and the things to do in Bangkok in 3 days.
If you're staying for a shorter while, do check out this 2 days in Bangkok itinerary. Continue reading "Budget Bangkok Itinerary: 4 Days for First Timers"
How to Plan a One Day Trip to Agra: Places to see, Food to try, and Agra Itinerary
Agra is a city in northern India's Uttar Pradesh state, home to one of the Seven Wonders of the World, the Taj Mahal. Although Taj is the primary reason people come to visit Agra, there are other sights worth seeing in Agra. Conveniently, these are all near the Taj Mahal and can be seen in one day. Read on for a perfect self-guided Agra itinerary for a one day trip to Agra. Continue reading "How to Plan a One Day Trip to Agra: Places to see, Food to try, and Agra Itinerary"
19 Best Food Cities in Europe for Every Food Lover
I love to explore and write about food. I think it is something that's just within me. To such heights, that I also sometimes plan my travels based on the food I am going to try there. I'm sure most of you must have been to some part of Europe, but have you wondered which are the best food cities in Europe? Continue reading "19 Best Food Cities in Europe for Every Food Lover"
Affordable Restaurants in Singapore: Where and What to Eat in Singapore
The question of what to eat in Singapore is like unveiling an endless puzzle of multi-sensory, multi-flavored culinary adventures. Being a successful country of many cuisines, it is best to explore food at affordable restaurants in Singapore which are hidden gems and only known to few. Continue reading "Affordable Restaurants in Singapore: Where and What to Eat in Singapore"


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Chandigarh (Face2News)
"The Punjab Government initiated 'Mission Tandarust Punjab' has met with unprecedented success and during the previous 2 months a total of 17,86,973 saplings have been distributed to the people with the process still continuing."
S.S.Dharamsot Disclosing this, the Forest Minister, Punjab, Mr. Sadhu Singh Dharamsot said that the saplings have been distributed amongst the masses under the 'Ghar Ghar Hariyali' campaign and 'I-Hariyali' app in various camps, programmes and nurseries. He also said that the aim of providing free saplings is to keep the environment clean and green and preserve ecological balance. He further said that the State Government's flagship programme 'I-Hariyali' app has got massive response from the masses who are receiving the saplings of their choice through online bookings. Giving more details, Mr. Dharamsot said that 148285 saplings have been planted in Amritsar forest division while in Bathinda forest division 175997, In Dasuha forest division 65804, In Ferozepur forest division 5226, In Gurdaspur forest division 31381, In Hoshiarpur forest division 72561, In Jalandhar forest division 44013, In Ludhiana forest division 229913, In Mansa 55393, In Sri Muktsar Sahib forest division 220818, In SBS Nagar forest division 60437, In Pathankot forest division 50573, In Patiala forest division 125000, In Rupnagar forest division 14889, In Sangrur forest division 258709, and In SAS Nagar forest division 180939 saplings have been planted.
The minister further said that the youth is playing an important role in carrying forward this movement of clean environment. He also emphasized that for every single tree felled minimum 5 saplings must be planted in order to maintain balance in nature because a sapling takes a lot of time in becoming a full blown tree. He said that if the people of Punjab take a pledge to plant more and more saplings besides ensuring their proper maintenance then once again the state would be lush with greenery.


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Let's Get Building!
Pre-K – K
Calling all builders! Throughout the week, your camper will choose an architectural project to design, plan and build. We'll look for inspiration in famous buildings from ancient cultures, use Museum exhibits to explore properties of earth and building materials, and learn how to transform a building from a scale model to a final product. In daily engineering challenges, we'll figure out how to build our structures stronger and safer as we test them against natural forces like earthquakes and hurricanes. Let's get building!
Camp Dates
June 24 – June 28
July 8 – July 12
July 22 – July 26
August 5 – August 9
Members: $290/week
General Public: $320/week
Morning Care: $20/week
After Care: $45/week
Lunch: $35/week (Vegetarian and Omnivore options)
Book Your Summer Camp Today.


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No products
Prices are tax included
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Find your favorite gift for your favorite man!
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Hand carved mug


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IF there's one dress to be seen in this season, it seems it's Issa's 'Lucky' dress.
From the red carpet to out and about in London, it's been spotted on everyone from Hilary Swank (who wore a specially commissioned version for the promotion of her film PS. I Love You - in her favourite Issa print we're told) and Scarlett Johansson to Alice Dellal, Kate Middleton and even Kristin Davis' alter ego, Charlotte York in Sex and the City.
Choose from black, white, red and new for autumn/winter 2008-9, a denim version, which is set to hit stores in the next two weeks.


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Explore Grange Hotels' Latest Blog Posts and Press Releases
London is full of exciting things to do but some are better known than others. Discover what hidden London has to offer in our list of secret London events!
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IBM Security Systems M2150-225 Exam Dumps
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Move Well, Live Well
Inclusive and accessible movement based activities that help people to live well for longer
Well, Well, Well...
Our unique Team Well programme helps organisations to provide a healthy and happy workplace!
We are the force behind Welland: A Festival of Joy - Calderdale's first festival of wellbeing, for the community of Elland!
Classes & workshops that enable people to take control of their own wellbeing through movement. Work. Enlighten. Learn. Live
We have recently contracted Sam and Alice at Curel to deliver a number of short workshops for us during two of our graduate development programmes...The workshops that Sam and Alice ran...helped us to be aware of the signals that our bodies were sending to us which links in nicely with how self aware we are. Sam and Alice were engaging, clear and kept the sessions fun and inclusive. I'm looking forward to the next time we work together.
A very comprehensive delivery and positive session proving all movement can be useful. The simplicity of the activities can be incorporated in daily practice. Very useful and motivational - thank you.


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Warriors coach, Sunday Chidzambwa has named a 32-man provisional squad for the COSAFA tournament set for South Africa from the 27th of May to 9 June.
The squad has a bulk of foreign based players with Chidzamba seeking to defend the title that Zimbabwe won last year.
Only South Africa and Angola have managed to defend the COSAFA title in the past.
COSAFA 2018 Provisional squad
George Chigova (Polokwane City)
Edmore Sibanda (Witbank Spurs)
Donovan Bernard (Ngezi Platinum Stars)
Chang Mariyoni (Triangle)
Alec Mudimu (CEFN Druids)
Teenage Hadebe (Kaizer Chiefs)
Kelvin Moyo (FC Platinum)
Byron Madzokere (Yadah Stars)
Liberty Chakoroma (Ngezi Platinum Stars)
Tendayi Darikwa (Nottingham Forest)
Jameson Mukombwe (FC Platinum)
Takudzwa Chimwemwe (Harare City)
Costa Nhamoinesu (AC Sparta Prague)
Ronald Pfumbidzai (Bloemfontein Celtic)
Honest Moyo (Highlanders)
Adam Chicksen (Bradford City)
Marshall Munetsi (Orlando Pirates)
Richard Hachiro (Herentals)
Andy Rinomhota (Reading)
Kundai Benyu (Oldham Athletic
Abbas Amidu (Entag El Harby)
Talent Chawapiwa (Baroka)
Leeroy Mavunga (Yadah Stars)
Khama Billiat (Mamelodi Sundowns)
Ovidy Karuru (Amazulu)
Tafadzwa Kutinyu (Singida United)
Marvelous Nakamba (Club Brugge)
Knowledge Musona (KV Oostende)
Evans Rusike (Supersport United)
Macaulley Bonne (Leyton Orient)
Tinotenda Kadewere (Djurgardens IF)
Kelly Lunga (Bonner SC)
Admiral Muskwe (Leicester City


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Today, car crash injuries are the leading cause of Traumatic Brain Injury-related death, with the highest rates among adults aged 20 to 24 years. If you find yourself in a situation where you've been personally injured following a car crash, medical malpractice, or an incident at work, it may be time to start thinking about hiring a personal injury attorney. A personal injury attorney can help you claim compensation and potentially win the settlement you deserve. Car crashes and falls can be extremely serious, and you're going to need some help with the case as it moves forward. In order to utilize a personal injury attorney, you have to take the proper steps to find the best one for your situation. Here are a few secrets to finding and working with a really good personal injury attorney. Find One Who Has Taken Cases to Trial in the Past As weird as it may be, there are many attorneys out there who handle personal injury cases but have never been inside a courtroom. Some attorneys are actually afraid of going in the courtroom. However, if your case needs to be taken to court, then it's extremely important to find an attorney
Monthly Archives: | March, 2018
Secrets to Working With the Best Personal Injury Attorney
Personal Injury When to Sue
There are some terms worth knowing at the start of this article. The idea is that they will give an understanding of the content in this article. They are motor vehicle accidents, personal injury attorney, personal injury attorney Portland OR, personal injury attorneys, personal injury law firm, personal injury law firms, personal injury lawyer, and more. There is a statistic worth noting at the start of this article as well. The statistics are in place to give a more detailed view of the subject matter in this article. It is: In 2015, 88,000 motorcyclists were injured. Car accidents happen. They happen because people are drunk, people are distracted, people are aggress
Is Legal Representation Necessary for Filing Workers Comp Claims?
Federal and state workers compensation laws are intended to help workers who have been injured on the job. In practice, however, the paperwork can be very complicated and difficult. For someone dealing with the effects of an injury and handling medical, insurance and other kinds of paperwork, it can be too much to tackle alone. Generally, workers who have a legal representative to file their claim have much more success in getting compensation and receive a larger settlement. Occupational illness and injury Work-related occupational injuries and illnesses are very common. In 2013 alone, over 3 million cases were reported. The most frequent type of workplace injuries are slips and falls. Th
Bitten by a Dog? 5 Things You Need to Do
No one expects to be bitten by a dog when they are out and about but it happens all of the time. Every year, at least 4.5 million people are bitten by dogs around the United States. When this happens, about 20% of dog bite victims need to seek medical help. That translates to more than 800,000 people going to emergency rooms and doctors' offices to be treated for problems they are experiencing due to the encounter with a dog. The most common victims of these attacks are children. Unfortunately, these bites are also some of the most serious. This often happens when children are playing with dogs they know. If you or your child has been bitten by a dog and required medical attention there are some things you can so, such as hire an accident lawyer to help. Here are some other steps you should take: Get t


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Sometimes inspiration can hit you in the most unexpected places. For Martin Niewood, author of FORGOTTEN VIOLETS, inspiration struck in a paralyzing nightmare. This nightmare was just the beginning of his process in creating an entire world that he calls the Domain. As an indie author, Martin has learned a lot about what publishing. Through his experience, he has learned five valuable lessons that he wants to share with our readers!
Have you ever had a nightmare so vivid that you couldn't escape it even after you awoke? I have. In fact, that was the inspiration for my new young adult novel, FORGOTTEN VIOLETS.
After a day, no a week, where everything had gone wrong, I crawled into bed thinking that things couldn't get much worse and yet somehow they did. My sleep was troubled and before long, I tumbled head first into the realistic horror of a night terror.
I dreamt that I was sitting in my living room and although the adjoining dining room appeared empty, I felt that someone or something was there. Suddenly, there was a flicker of movement and two dark eyes materialized as they narrowed, turned, and stared back at me. Immobilized by fear I recognized the form as human but it was covered in blistering black flames. Still paralyzed, I watched the slow motion morphing of the image into a dragon before gently dissolving into air. Although no longer visible, its presence was palpable and I believed that somehow it was watching me. I awoke from the nightmare shaking and covered in sweat.
Days passed but I couldn't shake the dream because it felt so real. I wasn't sure what it meant. Was it an omen? I questioned things that had never troubled me before. I became intrigued with questions like, 'Where do we come from?' The catechism answers I memorized as a child no longer satisfied me. I speculated from what real or imagined corner of hell that monstrous form had emerged. I wondered what would happen to me when I died. Slowly, the idea of an afterlife where souls were given a second chance emerged. I envisioned a world that I called the Domain.
I mused that the Domain was created by an unseen energy system and that its very existence depended upon maintaining the delicate balance between good and evil. Inspired by my fiery vision, I created Aiden Rose, a terrifying but disillusioned figure and realized that I would need Meadow Noone, a strong but naïve character to counterbalance the darkness of Aiden's world. All of the characters within FORGOTTEN VIOLETS lived within the confines of the Domain but not all of them were created equal for some like the Preternaturals, were born into the Domain with special gifts. Preternaturals like Aiden and Meadow had extraordinary powers that could be used for good or evil to affect the balance. These powers were enhanced by ingestion of a mysterious fruit called Elsyn, a gift that exacted a demanding cost.
I decided to tell the story of Meadow's journey through the Domain from her point of view because like many of the characters in the novel Meadow had made mistakes in her life on earth but unlike others, she was willing to learn from them and try again. Meadow's journey through a landscape of deceit and betrayal is full of missteps and mistakes but it is ultimately a triumph of hope.
Aiden Rose evolved from a fiery monster that terrified me one dark night at a time when I was unsure of my way. Meadow Noone was initially terrified of Aiden but she found the strength to overcome her fear and recognized Aiden for what he was. All of us face demons; some are real and some are self-created. The question is do we let fear consume us or do we rise above it as Meadow did.
If you have a story to tell, I encourage you to write. Writing is a very personal thing but if you intend to publish, there are some not so personal aspects to consider. When I started FORGOTTEN VIOLETS, I had no idea of how to go about Indie publishing and I made some mistakes. Here are a few things that I learned; I hope that you find them useful:
- It's never too early to start building your platform. I advise developing your website and social media outlets so that when your book is released you have a strong foundation of followers.
- Hire a professional artist to design your cover because people really do judge books by their covers.
- This might seem obvious but hire a professional editor. Although they may be expensive, they can take your writing to a new level. Consider having a developmental and copy edit of your manuscript.
- When your fully edited manuscript is finished, the hard work begins. Ensure that your work is protected by copyright; decide on the distribution channel and upload the formatted work; and market your brand as well as your book. If you can afford a publicist, he or she can help with the marketing campaign.
- Don't let the compliments go to your head or the criticism crush your spirit. You can learn from both.
Most importantly, keep writing and remember to have fun.


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$160 for single 8 consecutive week class non-CAV Membership Card Holders*
Non-CAV Membership Card Holder class enrollment includes one three-hour class and one three-hour session of open studio per week. All adult classes are eight (8) consecutive weeks.
Class Enrollment includes storage for your work, a locker for personal possessions during class, and of course assistance with choosing the best tools and Laguna clay to best suit your needs. We here at CAV are committed to ensuring that your experience is not only enjoyable, but one that keeps you coming back for more!
Also included is the use of the common facilities of The CAV Studios - a fully outfitted ceramics studio with a large range of equipment, including 18 wheels, hand-building tables, 2 slab rollers, wedging tables, glazing area, 3 extruders, and clay-friendly sinks.


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Zwölfer Junior Suite
Spacious and comfortable
ca. 60 m², for 2–5 Personen
- amenities include 2 bedrooms
- wooden floor
- corner bench with table and chairs
- bath or shower and separate WC
- make-up mirror, hair dryer
- telephone, radio and cable TV, Wifi, safe
- sunny balcony
wellness bag with bathrobe and slippers
Image if for illustrative purposes only and may differ from the original
Check availability and book
Prices listed are per person per day including halfboard. Not included is the spa tax (2,80 EUR per person/day).
Ski-Package: 7 days of exhilarating skiing including a 6-day ski pass for the Stubai glacier area.
Daytime rates are understood per person and day, including culinary highlights and the Stubai Super Card (from end of May 2019). Not included is the spa tax (2,80 EUR per person/day).
Summer-Package: Per person for 7 days half-board including daily Stubai Super Card (from end of May 2019) and 3 guided walking tours.


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Good morning everyone :)
This coming Wednesday , 23rd April , I will be in Hamburg to do an interview with a Leibstandarte Veteran , Herr Kurt Schmidt. He is the grandfather of one of my best friend. He was a SS Sturmann in 1941 and rose up all the way to SS Oberscharführer in 1944 until he was captured by the Russians. His commander at that time was SS Brigadeführer Wilhelm Mohnke.
My previous meetings with veterans were members of the Kriegsmarine who were part of the Monsun Uboot gruppe , http://monsun-uboats.blogspot.sg
Usually, my interview are very informal and friendly , but since this is my first interview with a ex Waffen SS soldier. I would really appreciate any advise :)
I have prepared a set of questions for him that his granddaughter , will check for any translation mistakes and also I too take into consideration his age (He will be 95 years old this year) , so Im always patient and will let them tell their story first.
I have 2 questions to ask you guys though :-
1) Does anyone here have contact with the HIAG in Hamburg ?? He would really like to meet up with fellow veterans
2) I plan to do a walking tour with his granddaughter who is one of my best friends and a native of Hamburg on friday. And it would be great to bring her along some militaria shops or museums. Can you guys recommend some ?? I plan to bring her to Helmut Weitze Antiquitäten , The Internationales Maritimes Museum Hamburg .. any others ??
As a side note - How I met her granddaughter was very amusing !! Im of Indonesian heritage and live & work in Singapore. But I love going back home to Bali , to meet up with friends and family and do lots of surfing :) And while at a party in Singapore a good german friend of mine introduced me to another german woman who married an Indonesian and living in Bali. We met again for my birthday dinner at Canggu Beach and she found out about my interest in history. Later, a couple of weeks when she was back for a short holiday , she phoned me and told me that her Opa, grandfather was a soldier too , and was a member of the Leibstandarte. She didnt know what this means until I gave her a brief introduction and my interest. She was really surprised and very proud of her Opa .... By the way, even though hes turning 95, he is smart enough to use skype via the iphone 6+ to speak with his granddaughter !! :)
Looking for all relevant info & items on WW2 German U-boats in Singapore and Asia for my research.


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Barcelona City - Zona Alta - Sarrià - Bonanova - Tres Torres | House
Detached for sale in Zona Alta, Barcelona | BCNP1198
This 437 m2 detached house is located on a tranquil block corner in the barrio Sarria, without sacrificing proximity to the shopping area, international schools, or city center access.
Renovation was completed in 2001 to exacting tastes, using quality materials that preserved unique features of the property dating back to 1947. These updates added modern functionality to the house.
The house is distributed across two floors where the main spaces are generous and elegant. Furthermore, the property features functional basement parking spaces, a fully equipped laundry and a complete service area with all the equipment. The private pool is framed by an all-natural garden, accompanied by a chill-out area under the lovely pergola.
It should be noted that this property was listed as historical by the Barcelona city hall because of its quality iron work and original painting. Without doubt, this house represents the perfect harmony between warmth and functionality.
Request more information about Warmth and Functionality in this Historic High Town HomeRef: BCNP1198
With an excellent connection to the city centre, the Zona Alta is one of the most exclusive residential districts of Barcelona. This neighbourhood hosts the Royal Tennis Club and the Real Polo Club of the city, two of the most select institutions of the Catalan capital. In addition, it enjoys calm and the proximity of the most prestigious health centres, consulates, and exclusive international schools.
In our portfolio of properties you can find from mansions to modern houses with gardens and pools, as well as apartments and penthouses located in the most renowned streets of the Zona Alta.
Contact our team of real estate consultants to learn more about this exclusive development
Sotheby's International Realty® is a registered trademark licensed to Sotheby's International Realty Affiliates LLC. Each Office is independently Owned and Operated.