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Rover duji dating 2010
Rover's Morning Glory - Wikipedia
February 2, at PM EST - Updated June 19 at PM Both Rover and Duji disagree with whom the other is or was dating and they thought they. Rover's Morning Glory is a syndicated hot talk morning radio show originating from Cleveland Duji (Susan Catanese) In January , Rover's Morning Glory returned to the airwaves in Columbus, Ohio at WRXS show each morning, but to access full-show archives dating back to , as well as being able to watch. As far as I can remember, when Rover and Duji broke up they From what I understand around Duji went on one or two dates with.
When a full-time on-air position became available, he volunteered to start a segment called Dare Dieter, in which he would do any stunt or dare submitted by listeners every Friday.
Rover admits to dating duji : Easy fish dating site
Dieter said if he ever turned down a dare he would go back to phone-screening, a promise that was often held over his head during the segment by listeners.
The feature was ended by Rover and CBS Radio management after Dieter suffered a serious injury and temporary paralysis during a stunt involving a barrel roll in July Events and special projects[ edit ] RoverFest[ edit ] An annual beer-drinking festival and concert to celebrate all-things-Rover.
The first RoverFest was held June 20, West 6th Street in the Warehouse District of downtown Cleveland was closed, a large stage was built, and food and beer vendors were present. Approximately 10, people made their way through the festival, surpassing expectations. A television special was taped to air on MavTV in October The event sold out with over 10, people attending. Sick Puppies, Saving Abel, and Coolio performed as main acts.
As usual, the calendar search was held, as well as skits related to the show. Rover's Morning Glory hold one golf outing in their home city of Cleveland, Ohio and also holds another golf outing in Rochester, New York, a long time affiliate with the show. The show conducts a search for local, non-professional girls to be in the calendar and offers cash and other prizes to the girl who is crowned Miss Morning Glory, who gets to be featured on the calendar's cover.
A large party is held for the release of the calendar usually in November or Decemberwhich usually has all 12 girls in the calendar and everyone from the show on hand to autograph copies of the calendar.
Duji's Back: WMMS Morning Show "Rover's Morning Glory" Is Back On Air! With Duji!
Over the next couple of months Dieter trained with a professional fight instructor for his first boxing match. Rover worked with the City of Cleveland to shut down a street in the downtown area, had a ring erected in the middle of the road and brought in beer-vending trucks.
Police estimated over 12, people came out to see the three-round fight, forcing the fight to start almost an hour early because of crowd control concerns. Esch knocked Dieter down a number of times during the fight, but each time Dieter was able to get up before the ten-count. Esch has since been in-studio and participated in other events with the show. The League of Extraordinary Morons[ edit ] The League of Extraordinary Morons consists of "Jackass"-style stunts where cast member compete to win money or a new car.
The segment airs on a weekly basis, typically on Friday, consisting of physical and eating challenges. The challenges were as follows: Week 1 - Drinking a blender concoction of disgusting items including chewed bubble gum, live earth worms, tobacco juice, clam juice, anchovies, sardines, wet dog food, dry dog food, live crickets, apple cider vinegar, poached fish testicles, hot sauce, curdled milk, raw eggs, cigarette butts, and tomato juice strained through used panties.
Week 2 - Targets were painted on the bare chest of each competitor. Manson first worked as a producer with the band Jack Off Jill and he helped name the band and produced most of the bands early recordings, and also played guitar on the song My Cat and had the band open most of his South Florida shows.
Manson later wrote the notes to the bands album Humid Teenage Mediocrity — Manson released his studio album, Born Villain, in May Cleveland — Cleveland is a city in the U. The city proper has a population of , making Cleveland the 51st largest city in the United States, Greater Cleveland ranked as the 32nd largest metropolitan area in the United States, with 2, people in The city is the center of the Cleveland—Akron—Canton Combined Statistical Area, the city is located on the southern shore of Lake Erie, approximately 60 miles west of the Pennsylvania border.
Clevelands economy has diversified sectors that include manufacturing, financial services, healthcare, Cleveland is also home to the Rock and Roll Hall of Fame. Residents of Cleveland are called Clevelanders, Cleveland has many nicknames, the oldest of which in contemporary use being The Forest City.
Cleaveland oversaw the plan for what would become the downtown area, centered on Public Square, before returning home. The first settler in Cleaveland was Lorenzo Carter, who built a cabin on the banks of the Cuyahoga River, the Village of Cleaveland was incorporated on December 23, In spite of the swampy lowlands and harsh winters, its waterfront location proved to be an advantage.
The area began rapid growth after the completion of the Ohio, growth continued with added railroad links. Cleveland incorporated as a city ininthe city, then located only on the eastern banks of the Cuyahoga River, nearly erupted into open warfare with neighboring Ohio City over a bridge connecting the two.
Rover admits to dating duji
Ohio City remained an independent municipality until its annexation by Cleveland inthe citys prime geographic location as a transportation hub on the Great Lakes has played an important role in its development as a commercial center. Cleveland serves as a point for iron ore shipped from Minnesota.
InJohn D.
Rockefeller founded Standard Oil in Cleveland, other manufacturers located in Cleveland produced steam-powered cars, which included White and Gaeth, as well as the electric car company Baker. Because of the significant growth, Cleveland was known as the Sixth City during this period, bydue in large part to the citys economic prosperity, Cleveland became the nations fifth largest city. Johnson among its leaders, many prominent Clevelanders from this era are buried in the historic Lake View Cemetery, including President James A.
Garfield, and John D. In commemoration of the centennial of Clevelands incorporation as a city, conceived as a way to energize a city after the Great Depression, it drew four million visitors in its first season, and seven million by the end of its second and final season in September The exposition was housed on grounds that are now used by the Great Lakes Science Center, following World War II, the city experienced a prosperous economy.
In sports, the Indians won the World Series, the hockey Barons became champions of the American Hockey League, as a result, along with track and boxing champions produced, Cleveland was dubbed City of Champions in sports at this time 4. Rock music — It has its roots in s and s rock and roll, itself heavily influenced by blues, rhythm and blues and country music. Rock music also drew strongly on a number of genres such as electric blues and folk. Musically, rock has centered on the guitar, usually as part of a rock group with electric bass guitar.
Punk was an influence into the s on the subsequent development of subgenres, including new wave, post-punk. From the s alternative rock began to rock music and break through into the mainstream in the form of grunge, Britpop. Similarly, s punk culture spawned the visually distinctive goth and emo subcultures and this trio of instruments has often been complemented by the inclusion of other instruments, particularly keyboards such as the piano, Hammond organ and synthesizers.
Duji's Back: WMMS Morning Show "Rover's Morning Glory" Is Back On Air! With Duji!
The basic rock instrumentation was adapted from the blues band instrumentation. Melodies are often derived from older musical modes, including the Dorian and Mixolydian, harmonies range from the common triad to parallel fourths and fifths and dissonant harmonic progressions.
Critics have stressed the eclecticism and stylistic diversity of rock, because of its complex history and tendency to borrow from other musical and cultural forms, it has been argued that it is impossible to bind rock music to a rigidly delineated musical definition. These themes were inherited from a variety of sources, including the Tin Pan Alley pop tradition, folk music and rhythm, as a result, it has been seen as articulating the concerns of this group in both style and lyrics.
Christgau, writing insaid in spite of some exceptions, rock and roll usually implies an identification of male sexuality, according to Simon Frith rock was something more than pop, something more than rock and roll.
Rock musicians combined an emphasis on skill and technique with the concept of art as artistic expression, original. The foundations of music are in rock and roll, which originated in the United States during the late s and early s. Its immediate origins lay in a melding of various musical genres of the time, including rhythm and blues and gospel music, with country.
InCleveland, Ohio disc jockey Alan Freed began playing rhythm and blues music for a multi-racial audience, debate surrounds which record should be considered the first rock and roll record.
Chicago — Chicago, officially the City of Chicago, is the third-most populous city in the United States. Chicagos culture includes the arts, novels, film, theater, especially improvisational comedy. Chicago also has sports teams in each of the major professional leagues.
The city has many nicknames, the best-known being the Windy City, the name Chicago is derived from a French rendering of the Native American word shikaakwa, known to botanists as Allium tricoccum, from the Miami-Illinois language. The first known reference to the site of the current city of Chicago as Checagou was by Robert de LaSalle around in a memoir, henri Joutel, in his journal ofnoted that the wild garlic, called chicagoua, grew abundantly in the area.
In the midth century, the area was inhabited by a Native American tribe known as the Potawatomi, the first known non-indigenous permanent settler in Chicago was Jean Baptiste Point du Sable.
Du Sable was of African and French descent and arrived in the s and he is commonly known as the Founder of Chicago.


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Sir Alex Ferguson is looking forward with relish to the Champions League tie he asked for after his Manchester United side were paired with mighty Real Madrid in Nyon yesterday.
On Tuesday, Ferguson said he would be quite happy with a two-legged encounter with the holders and nine-times winners.
And that is exactly what he got, both in the rehearsal and draw proper at Uefa headquarters.
If that was not enough, United also learned that if they emerge victorious, they will then face either Juventus or Barcelona in a mouth-watering semi-final, ensuring that should they make the May 28 final at Old Trafford, they will have come home the hard way.
The omens are promising. On the three occasions the two giants of European football have met in the competition, the victor has gone on to lift the trophy.
Real must be regarded favourites though, with a side containing Zinedine Zidane, Ronaldo, Raul, Roberto Carlos and Luis Figo and Ferguson gave the impression he would like to be there as a fan even if he did not have the demanding task of trying to beat such a star-studded side.
"It is without a question a fantastic, attractive draw against the most successful European Cup team of all time," he said.
Meanwhile, Celtic hero John Hartson said that the Uefa Cup semi-final draw with Portuguese outfit Boavista was the outcome everyone at Celtic Park wanted.
That was the lucrative reward handed to the Scottish champions forllowing their triumph over Liverpool at Anfield. Celtic avoided Italian giants Lazio and FC Porto, who destroyed them in the Champions League in Portugal last season.
"I hope we can now go to the final," enthused Hartson. "I think the draw we all would have wanted was Boavista at home.
"I am particularly pleased to have a home draw first as it's been good to us all the way through."

subset: commoncrawl


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Aisha J. Thomas began her career in real estate in 2001. She specializes in Buyer Agency and Investment Sales. She decided to expand her brand into the commercial real estate arena in 2013. She is a licensed real estate broker in Michigan and Georgia and a licensed salesperson in California.
She is a member of various professional, educational and civic organizations including the Atlanta Commercial Board of Realtors (ACBR), Greater Metropolitan Association of Realtors, Women's Affordable Housing Network, International Council of Shopping Centers, Atlanta Bar Association (Student). She is former member of the Urban Land Institute and NAIOP, the Commercial Real Estate Development Association. In the past she had the pleasure of serving as a Board of Director of the Detroit Association of Realtors and currently serves as a Board of Director for Quest Community Development Organization. She has been featured and quoted in two issues of Black Enterprise Magazine's special First Time Homebuyer's Editions, VoyageATL Magazine, many national real estate blogs, local radio as well as HGTV's hit show, My First Place. In addition to selling real estate, Aisha advocates for affordable and fair housing by volunteering with the Atlanta Legal Aid Society and Housing Georgia. This passion led to a position ensuring Developer Compliance with Federal Affordable Housing Programs for the City of Atlanta's Department of City Planning. In early 2019, Aisha was appointed by the Honorable Mayor Keisha Lance Bottoms to the City of Atlanta In Rem Review Board.
Aisha earned a Bachelor of Science and Master of Arts from Wayne State University, and a Juris Doctor from the University of Detroit Mercy School of Law. She is also a 2014 alumni of Project Real Estate Associate Program-Los Angeles and was admitted into the University of Southern California Lusk Center for Real Estate Ross Minority Program in Real Estate. In 2015, she completed ACBR's Inaugural Diversity Mentorship Program and is currently completing coursework to earn CCIM certification. In addition to her love of real estate and law, she enjoys live concerts, traveling, expanding her culinary palate and spending time with her sons.


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Land Rover Discovery 0.0 HSE TD6 AUTO with Desirable Factory Fitted Extras - £60,990
For all enquiries please call 01772 950 565View Dealer Website
Land Rover Discovery 0.0 HSE TD6 AUTO with Desirable Factory Fitted Extras
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- Mileage: 28750
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Vehicle Description
Our internet team check our prices on a daily basis to ensure our guests receive the best possible deals on like for like vehicles - Ask about our unique Warranty4Life and personalised videos. Our Discovery is fitted with 4,339 worth of optional equipment including Premium Metallic Paint, Electrically Deployable Tow Pack 1, Upgraded Alloy Wheels, Black Roof Rails and Black Pack. It is finished in Premium Metallic Carpathian Grey Paint with Ebony Leather Upholstery plus 20 inch Black Gloss Alloy Wheels. Standard specifications highlights include Hill Launch Assist, Hill Decent Control, Driver Condition Monitor, Blind Spot Monitor, Keyless Entry, Front Fog Lights, 8 Speed Automatic Transmission, Tyre Pressure Monitoring System, Cup Holders, 10.2 inch Touchscreen, Terrain Response System, Rear Parking Sensors, Rain Sensing Windscreen Wipers, Electrically Heated Door Mirrors, Navigation System, Meridian Sound System, Lane Departure Warning System, InControl Apps, Heated Front Windscreen, Powered Gesture Tailgate, 12 Way Electric Front Seats, Driver Drowsiness Monitor, DAB Digital Radio, Cruise Control, Two Zone Climate Control, CD/DVD Player, Automatic Headlights, Auto Dimming Rear View Mirror and All Wheel Drive. Ask about our unique Warranty4Life and personalised videos.
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Finals Week
April 13, 2018
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Finals week might be the most stressful week for a high school student. With all of the unwanted studying that is required to even pass, no one wants to do it. Hardly anybody is actually willing to put the extra work in to ace an exam, and that is just one test. Hours after hours of studying has to be put in to pass one test.
Even just for one week, people have stuff to do. It is such an unwanted task that even if you do put in enough work you still might fail. Last year I studied for an entire day for a Spanish test, and I still failed. It is ridiculous how hard these finals are. It does not matter how hard you tried or how hard you did during the school year. If you run into a hard finals, your grade will drop.
If anyone is worried about finals week you are not alone. I know there is still a month until finals, but if you care about your grades at all you will be worried. It does not matter how much studying you put in, you could still fail.LEVENT KONUK
Marshall Ingram was born and raised in Houston, Texas. He has two parents and two sisters. One sister is 14 years old and one is 3 years old. Marshall...


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Posted on June 8, 2019
The fourth edition of the Environment Festival in Chisinau was dedicated to the quality of air and to the reduction of its pollution
Hundreds of people brought collected batteries and used equipment for recycling purposes, calculated how many trees they owe the planet, checked the quality of water they drink and air they breathe, participated in workshops, learned more about environment, and even played - so they celebrated the World Day of Environment in Chisinau, at a festival which is already at its fourth edition.
The event took place on June 7 in Valea Morilor Park, and its location was not chosen by chance. The park is an oasis of clean air in Chisinau, the city with the most polluted air in the Republic of Moldova.
"We are the ones who have to protect the planet. Modernizing and technologizing life has led to environmental pollution. It is important that each of us act to diminish the sources of pollution and, consequently, the negative impact on health. The environment is strictly correlated with health. We can start by giving up to personal cars at least one day a week in favor of public transport or bicycle," said Valentina Ţapiş, State Secretary, Ministry of Agriculture, Regional Development and Environment, in her opening speech.
Gheorghe Teleaga, Environmental Protection Specialist at the National Agency for Public Health, said: "We are glad that many people interested in environmental issues and air quality participate in the event. We are all aware that this affects our health. We are dedicated to contributing by evaluating and providing accurate data on air quality."
Air pollution is not always visible, but its effects are shattering: "About 9 out of 10 people in the world breathe polluted air, this phenomenon is a global public health emergency and requires our immediate action. Every year, 7 million deaths are due to exposure to polluted air, which causes strokes, heart disease, lung cancer, chronic and acute respiratory diseases, including asthma. Children, women and people working outdoors are the most affected. To protect our health, we need to overcome air pollution together," said Stela Gheorghita, coordinator of emergency public health programs at the World Health Organization Office in the Republic of Moldova.
At the event, Orange, in partnership with the innovation laboratory of UNDP Moldova and Chisinau City Hall - Green City Lab, installed sensors that measure air quality. This year, five such sensors will be installed in the city to inform the population about the parameters of the air they breathe.
"We are all responsible for the pollution and only together we can help reduce harmful emissions and improve the quality of the air we breathe. Together we can transform gray into green," emphasized Valeria Ieşeanu, Head of Programme at UNDP Moldova.
The sectors that generate the most air pollution in the country are: energy, transport, residential, i.e. households. Efforts must be directed towards reducing pollution sources and replacing them with environmentally friendly technologies, as the Festival's organizers have emphasized.
At the event, visitors communicated with specialists working in water and air testing laboratories. They could calculate their CO2 footprint equal to the number of trees owed to the planet.
This year as well, the quest facility brought by the Small Grants Programme of the Global Environment Facility was very popular; visitors could guess the waste degradation period. The NGO Junior Achievement Moldova presented an innovative water filtration system and temperature storage for fish pools, invented by the school company "Growell".
The NGO Association for Waste Recovery and NGO Ecovisio organized workshops on collage, selective waste collection, mesh making, eco-friendly table games, carpet yoga. Participants also enjoyed free legal advice on environmental issues provided by NGO Eco Contact. The Association of Environmental Journalists and Ecological Tourism depicted the credible sources of information on environmental issues.
The program of the Environment Festival included entertainment for adults and children, vinyl mix music by DJ Gonzo, fair of natural, reusable, recycled, nature-friendly products and vegetarian food.
The special guests of the event were Balkan Taksim band, well known by the way they perform folklore from the Balkans and the Romanian Carpathians, blending with several styles of music (electronics, trip-hop, Balkan psych, rhythms from the Carpathians).
The Environment Festival is organized by an initiative group, in partnership with the World Health Organization, the United Nations Development Programme, the Small Grants Programme of the Global Environment Facility, the Ministry of Agriculture, Regional Development and Environment, the Ministry of Health, Labor and Social Protection and the Association of Environmental Journalists and Ecological Tourism, with the contribution of NGO Ecovisio, NGO Eco Contact, NGO Junior Achievement Moldova, NGO Association for Waste Recovery, Association for Arrangement and Reconstruction of Chisinau, NGO The Ecological Movement of Moldova, NGO National Environmental Center, Limon LTD, Bricomol Professional LTD, METRO Cash & Carry Moldova.


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Inquiries, insights, and imaginings from a small town girl who wants to do some good in this life.
Tuesday, January 11, 2011
In My Own Skin
I am loving my forties. My older sister told me 13 years ago that the thirties were the best decade, but I have to disagree. Oh sure, I have a few more wrinkles than I had 10 years ago, but in the past few years I have sensed a certain wisdom emerging within me. I have become more intuitive, more aware. Bolder. Happier.
A few years ago I was in a very bad place. I was angry. I was hurt. There were a number of reasons as to why, but they need not to be mentioned. Let me simply say, that emotion of anger exhausted me. I fought too many battles and tried my best to stand up for what I believed to be "right" within several different circles of my life, only to be met with failure on more than one occasion. I grew cynical. It wasn't pretty. I started to lose myself. And then one day I leaned on an old mentor. His words gave me a new perspective on life. Thanks Roger.
Today, one of the old ghosts came back to test me. But I spotted it the second it appeared. It came to rattle me, to spit on me, to mock me, or to otherwise knock me down. It was cunning, arriving in costume and using words disguised in initial flattery. However this time, I acknowledged the ghost's pain. I saw its loneliness and I threw it a lifeline. I found no need to defend myself or to argue my position. I simply listened. I tried my best to offer up compassion and the altruism that I knew it had lost within itself, however temporarily. I didn't take its abuses personally. It was not about me.
In giving up the fight, I have become stronger. I no longer need to be "right". I no longer need to battle. I know who I am, for better or for worse. I continue to reflect, to listen and to observe. I continue to learn and I continue to grow. Oh, and believe me, I'll still work to find my quiet ways to affect positive changes, make no mistake about that. And if I deem there's a need to boldly take center stage again for the sake of a cause I believe in, I'll enjoy that too for a short time. I've been comfortable in the spotlight for years now but I know when it's time to make my exit. I'm not going anywhere. I'm just looking at things a little differently.
There's a quote that reads, "Practice as though you are the worst. Perform as though you are the best". I'll never stop working to learn more about this world and its people. I may have a long way to go, and hopefully I have many more decades to experience, but I'm loving my forties because I am truly and perhaps finally comfortable in my own skin.
2 comments:
- AnonymousJanuary 11, 2011 at 11:42 PM
I LOVED this entry! Thank you so much for writing it! I feel as if I should say sorry for whatever "ghost" that creeped up today, but it sounds like you handled it perfectly. As someone who is trying to figure things (meaning "life") out at the moment, this piece was great to read. It's good to know that people you think of as role models have these thoughts and experiences too. I often think of you, and many of my other role models, as indestructible figures. It's good to know we all have similar struggles; it's humbling. If that makes sense. I really enjoyed this. Thanks an awful lot for being you. :)ReplyDelete
I agree with Brandon. I don't particularly like perfect people.ReplyDelete
You go, girl.


text: Gold House flag (92) WOW Share Kaze Open in the application»Other Projects By The User (16) Used Brick Sets: Starter Pack #1Slopes AdvancedCats Win a $25 iTunes Gift Card every week! Enter to win and download anything from the iTunes Store! 15.03.2014 552 bricks 02h 08m 15898 downloads Created in: Report this project


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1989 cutlass ciera 2.8ltr running little rough and feels like it wants to stal
1990 Oldsmobile Cutlass Ciera
1989 cutlass ciera 2.8ltr running little rough and feels like it wants to stal
(1990 Oldsmobile Cutlass Ciera)
firat time it happen i was driving it was driving fine got home park it went back out it crank didnt turn over so i took plugs out clean then try it sgian cranked but would not crank over the i pump the gas peddle still nothing then went inside came back out i cranked it started up but running roughdrove it felt like it was going to stall took it to a garage said need plugs wires and fuel filter so he put it on start it running fine the heading hone it started up agian can feel it running little rough got to a stop light then it stalled it started right back up took it back to the garage he told me to leave it by the way keep in mind the engine light never came on at all he put it on a machine to see it a code comes up nothing is comming up whats wrong with it need more advice ??????????
2 answers & 1 comment
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firstly, there are the gooshes. these are those of you who watch too many chick flicks and expect every holiday to be romantic, perfect, and bloggable. you'll for sure cry on valentine's day, either because everything lived up to your expectations or because it didn't. for you, stars lyrics for the one you love.
the second group of people like valentine's day, but aren't overboard about it. they're still on the boat. they're the boaters. to you, valentine's day is a good excuse to give a card, eat more chocolate than usual, go on a date, have a girls' night out. for you, a card you could give to your mom, your sister, your best friend, or your husband. or whoever. the mailman, maybe. your dentist. you know, etcetera.
the third group of people are the haters. obviously. this group acknowledges valentine's day with angry facebook statuses and comments regarding commercialism and stories of horrible valentine's days past. {trust me, i know. i once spent valentine's day sitting on a couch with my roommate and her fiance. we didn't even watch a movie or anything. as far as i remember, we just sat there and thought about how we all wished i wasn't single. i don't remember anything else about that night.} contrary to popular belief though, the haters are not all single. some people love their significant other and hate valentine's day. for you, a card you can give your at least one other friend who hates valentine's day.
the fourth group is more hate-y than the haters and they don't even acknowledge it. i think, if you think about something even a little, you still have a tiny little spot of your heart that could one day learn to love it. the fourth group hates valentine's day so much that they refuse to think about it at all. which means they didn't read this whole post. which means i didn't go to the trouble of designing a card for them.
because they're silly.
{if you'd like to see the printable cards i made for the blogosphere last year, click HERE.}


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Forget something during Black Friday/Cyber Monday? Check out the Week of Deals!
Member Since: November 11, 2012
Country: United States
News - Your August Caption Conte… about 6 years ago
You can't put that here, everyone will see it. Where it is will be fine.
News - Your April Caption Contes… about 7 years ago
I thought I was going to be ahead $100 but to get rid of these tiny robots is going to cost more than that. I never should have parked in the front spaces at sparkfun for the whole day, Now I need a new car.
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Lucky is trying to draw everyone attention to our new division: Bark Fun!!
No public wish lists :(


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Škofja Loka is known as a medieval town with its history dating back to the 10th century. The Selska Sora river runs through the town with access bridges, restaurants and bars providing pretty riverside viewpoints.
While the town is firmly steeped in Slovenian history, there is an air of Italian influence in some of the architecture to be seen as you walk around.


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Travel Inn Sugar Creek
You can evaluate and book hotels applying Google Search. This gripping, stranger-than-fiction espionage thriller brings to life the outstanding correct story of Moe Berg, the skilled baseball player who became a World War II spy. A dark psychological thriller with heart-pounding suspense, Prior to HE LONGS is book #10 in a riveting new series—with a beloved new character—that will leave you turning pages late into the evening. The Summoner's Handbook reveals the story of James Baker – the epic journal that inspired the series hero, Fletcher, to uncover his personal summoning abilities.
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This is a war, she says, "with so numerous casualties that we should really call it by its correct name, this war with so quite a few dead by police, by violent ex-husbands and partners and lovers, by people today pursuing power and profit at the point of a gun or just shooting initially and figuring out who they hit later." To get to the root of these American crises, she contends that "to acknowledge this state of war is to admit the will need for peace," countering the despair of our age with a dose of solidarity, creativity, and hope.
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Via a series of daring escapades deep inside a dark and dangerous criminal underworld, Han Solo befriends his mighty future copilot Chewbacca and meets the notorious gambler Lando Calrissian, in a journey that will set the course of a single of the Star Wars saga's most unlikely heroes. American Horror Story is an anthological miniseries that tracks a distinctive terrifying tale of Americana every single season. As brought to life in the bestselling Summoner series, the magic of summoning is also an art, with a story of its own.
Google Images: Come across pictures from your Google Photographs by looking my pictures or my photographs from new york in 2013. Season five is The Last Ship at its most epic, upping the ante on action and excitement, but at its core, it is a meditation on the charges of prolonged war and the toll it takes on the heroes who fight it. Board the Millennium Falcon and journey to a galaxy far, far away in Solo: A Star Wars Story, an epic action adventure with the most beloved scoundrel in the galaxy.
Travel Inn Sugar Creek – The Summoner's Handbook reveals the story of James Baker – the epic journal that inspired the series hero, Fletcher, to uncover his own summoning skills.


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Create a great coffee with a rich aroma and the full flavour of a classic espresso - just without the caffeine!
You can enjoy Kimbo blends in capsule form. Each box contains 20 individually packed capsules in a protective atmosphere for perfect freshness. Easy to use and won't make any mess, they can be used in all machines that take rigid capsules of the same form and size. A consistently great coffee flavour every time!
PLEASE NOTE - THESE ARE PLASTIC CAPSULES COMPATIBLE WITH THE KIMBO CAPSULE MACHINES. If you are looking for ESE Pods, please click here.


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The sound of classic British EQ is absolutely legendary and has enhanced many a great recording. Emulating this classic British design, the Solar 69 EQ adds definition to kick drums, shapes electric guitars, and adds shimmer to acoustic guitars and vocals without sacrificing body.
Classic British EQ
Compatible with Studio One Artist and Professional (Versions 3.5.6 and higher)
Functions as an additional EQ model in the Fat Channel XT Plugin in Studio One
Also Compatible with StudioLive Series III Console and Rack Mixers
Functions as an additional EQ model in the Fat Channel processing section of StudioLive Series III Mixers
Compatible Mixer Models:
StudioLive 16 Series III
StudioLive 24 Series III
StudioLive 32 Series III
StudioLive 16R
StudioLive 24R
StudioLive 32R


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6:30 pm - 9:30 pm
Toronto Animated Image Society (TAIS)
Creative skills development
INSTRUCTOR Bryce Hallett
Sept 26, Oct 3, 10, 17 2017
6:30pm – 9:30pm
4 sessions
Non-member $220 / TAIS Member $180 / Subsidized $100
This 4 week course covers the fundamentals of animation for those just starting out, or those looking for a refresher. Your instructor will provide in-depth instruction on the 12 principles of animation, as explored using hand drawn exercises and examples. All participants will finish the course with at least one short animated sequence. Materials provided.
4 week Course on the 12 Principles of Animation
- Squash and Stretch
- Anticipation
- Staging
- Straight Ahead Action and Pose to Pose
- Follow Through and Overlapping Action
- Slow In and Slow Out
- Arc
- Secondary Action
- Timing
- Exaggeration
- Solid drawing
- Appeal
The course will take place in TAIS Studios, located at 1411 Dufferin Street, Unit B. Limited parking is available onsite.
The course instructor, Bryce Hallett, is an independent animator with 17 years experience in the industry. He has worked in a variety of styles and mediums and his animation can be seen in comedies, documentaries, advertising, and corporate and educational videos both online and on television in North America and Europe. He is a graduate of Sheridan College's Classical Animation program as well as the Canadore College graphic design program and has taught various animation workshops with TAIS, Teletoon, and independently. Recently he has taught storyboarding for Seneca College's animation program and has won some awards for his animated commercials which makes his mom proud. Click here to view Bryce's online portfolio.
TAIS Workshops are presented with the support of the Ontario Arts Council, and the Canada Council for the Arts


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VANCOUVER, 30 JANUARY 2001 – With Groundhog Day just around the corner (2 February for those of you still in hibernation), The Humane Society of Canada offers you Groundhogs 101, a primer to make this day even more fun and popular. "People hold their breath, waiting in anticipation to see whether or not their favourite local groundhog sees his/her shadow," according to Al Hickey, Western Regional Director of The Humane Society of Canada (HSC). Legend has it that if the groundhog sees his shadow then we can expect six more weeks of winter, and it he does not then spring is just around the corner.
"However, once spring arrives, not everyone wants to cuddle up with groundhogs. We're asking farmers, gardeners, stable owners, groundskeepers and golf course owners to give these critters a break," explains HSC Executive Director, Michael O'Sullivan.
"Learning to live peacefully with groundhogs is not only the right thing to do, it also makes common sense. It makes more sense for farmers and horse owners to deter groundhogs from certain area, and allow them to live in nearby areas. If this doesn't work, knowing where the groundhog holes are and making these burrows off limits to machinery, horses and other animals -- instead of killing a groundhog, whose place will simply be taken by another one who may dig yet even more burrows, " he said.
"Life doesn't offer us 100% solutions that make everybody happy. People need to realize this is also true when dealing with wildlife. We need to all get along a bit bitter," said O'Sullivan. Gardeners and groundskeepers can plant extra vegetables, or fence off small gardens with appropriate material.
Noisemakers like an aluminium pie plate attached by a string to a stake in the ground, a barking dog, or other humane deterrents are other tips. In drastic situations where nothing else works, using a humane box trap to capture and relocate the animal may be considered.
O'Sullivan warns that using poisons, traps or guns may be illegal, cruel and not selective. "You can wind up harming birds, house-pets, farm animals, other wildlife and even children and adults. It's like using a cannon to swat a fly -- there's a lot of collateral damage and normally you miss the fly," he said.
"Knowing that when it comes to how animals are treated 'ignorance is not bliss' we decided to use this special day to educate people about groundhogs." said O'Sullivan, who offers up the following little known information about these wonderful animals:
- groundhogs are also commonly referred to as woodchucks and marmots
- if attacked groundhogs try to reach their burrows, but, if cornered or confronted, they can provide plenty of fight
- generally weigh between 5 and 14 pounds
- live in pastures, meadows, fields and open woods throughout much of southern Canada
- groundhog burrows are generally 5 to 30 feet in length, with branching tunnels, and 2 to 3 feet below the surface of the ground
- groundhogs are active by day
- eat a variety of vegetation including grasses and clover
- 2 to 6 young are born in April or May
- groundhog burrows provide homes for other animals including cottontail rabbits, raccoons, skunks and foxes
- groundhogs fertilize the earth and loosen and aerate the soil
"Groundhog Day is a fun day when we 'find out' how many more weeks of cold weather that we have to endure" says O'Sullivan. "My hope is that by learning more about this remarkable creature we can turn this 'fun' on February 2 to 'respect' or at least 'tolerance' for the rest of the year."
CONTACT: Michael O'Sullivan by toll free 1-800-641-KIND or Michael on his cell phone (416) 876-9685 or at www.humanesociety.com via twitter at www.twitter.com/HSCanada and on Facebook at: http://www.facebook.com/pages/The-Humane-Society-of-Canada/211468055538280
[For more than 17 years, Al Hickey was the Chief Executive of the BC SPCA and before that headed up the Alberta and BC Chambers of Commerce, and was the Executive Director of the Boys and Girls Club of Greater Vancouver. He has been The HSC Western Regional Director for over 12 years. He has 4 children and 6 grandchildren. For his lifetime of achievement dedicated to helping people, animals and the environment, we have bestowed upon him our prestigious Heroes for Animals Award, shared by only a handful of people and organizations.
A father with two children, and a houseful of dogs and cats, Michael O'Sullivan has worked across Canada and in over 110 countries during the last 40 years helping people, animals and nature.]
The Humane Society of Canada (HSC) works to protect dogs, cats, horses, birds, rabbits and small animals, livestock, lab animals, wildlife and the environment. We carry out hands on programs to help animals and nature, mount rescue operations, expose cruelty through hard hitting undercover investigations, work to pass laws to protect animals, use a multidisciplinary approach, support animal shelters and wildlife rehabilitation centres, and spread the word about how to help animals and nature through humane education.
The only organization of its kind, seven days a week, The Humane Society of Canada (HSC) works across the street, across Canada and around the world helping people, animals and the environment.
The Humane Society of Canada (HSC) depends entirely on donations to support our programs to help animals and the environment. All donations are gratefully acknowledged with a receipt for income tax purposes. If you would like to support our educational campaigns that protect animals and the environment please make a donation here. Because when it comes to fighting cruelty and violence, we don't give up. Ever.


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OverDrive (All Campuses)
- This Task has been designed for use by all roles. For all roles
With OverDrive, you can borrow and enjoy free eBooks, audiobooks, and more from your library or school's digital collection. All you need to get started is an internet connection and a library card or student ID.
ContactsInformation Technology Additional Support Resources
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I've started a massive SPAM purge, any accounts that have spammed are being removed, also for a short period new user signups are disallowed until the SPAM cleaning is finished.
35% OFF For 3 Months on Centohost.com Dedicated Servers + IPv6 ready + Free setup!
Discussion in 'Hosting Offers' started by Staeagle, Dec 2, 2019.


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Watch studio previews for a huge range of recent and classic movies or tv shows avaliable from the Unbox video download service. The Amazon Unbox video downloads store has thousands of DVD-quality TV shows, movies, and more for you to purchase or rent.
If you liked this post, buy me a beer


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Jobs & Economy
Too many folks have been left behind in this economy. More than 6 million Americans who want a job don't have one. Another 4.3 million are involuntarily working a part-time job instead of a well-paying, full-time job. Congress must do more to ensure everyone in our country shares in the benefits of growth.
Tax Policy
In 2017, Republicans rammed a tax bill through Congress without holding a single hearing or listening to expert witnesses. Their law raises taxes on the middle class to pay for tax breaks for corporations and the wealthiest 1 percent. While the corporate tax cuts are permanent, tax cuts for middle-class families disappear over time. By 2027, fully 83 percent of the law's benefits go to the top 1 percent of income earners.
As Chair of the House Ways and Means Committee's Subcommittee that handles tax policy, I'm committed to enacting real tax reform that will boost the middle class. For example, I've authored legislation to make the Work Opportunity Tax Credit permanent so people who consistently face barriers to employment can find good, middle class jobs. I will continue working to create a tax code that benefits everyone in America.
Growing the Middle Class
Middle income wages have not kept pace with the rising cost of living. Making up these lost income gains must be a priority. That's why I'm a cosponsor of the Raise the Wage Act, which would increase the federal minimum wage from $7.25 to $15 an hour by 2024 and end the minimum wage disparity between tipped and non-tipped workers. The House of Representatives passed the Raise the Wage Act in July 2019. Majority Leader Mitch McConnell must allow a vote in the Senate without delay.
Small Business
Small businesses are a key driver of our economy that reinvest directly in our communities. I've long-supported simplifying the tax code for our small businessowners so they can spend more time growing their businesses and less time on accounting. Please know I'll do everything I can to support our district's small businesses.
Fixing our roads, bridges and waterways is one of the best ways to create jobs and put Californians to work. It would also lower hidden taxes on our businesses and communities caused by traffic congestion, vehicle collisions and increased auto maintenance. In May 2019, the American Society of Civil Engineers found the poor condition of California's roads cost drivers $61 billion a year. That's why I support smart federal investments in infrastructure.
Fire Recovery
The fires that have swept through our district in recent years hit middle class families hard and I'm committed to helping survivors get back on their feet. I worked hard to secure federal grants that help displaced families find housing and meet other basic needs. I was also an original cosponsor and voted to enact the California Wildfire Disaster Tax Relief Act. This law makes it easier to rebuild a home using money from a retirement account, makes it easier to claim deductions for uninsured property and helps fire-damaged businesses keep paying employees. In addition, I've authored the Small Business Disaster Relief Act of 2019, which would provide local businessowners with access to disaster assistance loans and grants through the Small Business Administration.
Everyone in our country deserves a fair shot at the American Dream. Please know I'll never stop working to grow our middle class while growing our economy.
More on Jobs & Economy
Washington – Today Rep. Mike Thompson (CA-05), a member of the House United States Mexico Canada (USMCA) Trade Agreement Working Group, stood in support of the recently-released and newly-negotiated trade agreement between the three nations. A statement from Thompson is below.
Washington – Today, House Ways and Means Subcommittee on Select Revenue Measures Chairman Mike Thompson (CA-05) announced his opposition to the Administration's potential change that would index capital gains taxes to inflation.
Washington – Today Rep. Mike Thompson (CA-05), Chairman of the House Ways and Means Subcommittee on Select Revenue Measures, voted to pass H.R. 1994, the Setting Every Community Up for Retirement Enhancement (SECURE) Act of 2019. This bill expands access to retirement plans for employees of small businesses, makes it easier for home health care workers in California to access retirement savings tools, and eliminates an unfair and unjust tax hike on Gold Star families caused by mistakes in the Republican tax law. A statement from Thompson is below.
Thompson, Reed, Pascrell, Rice and Suozzi Introduce Bill to Permanently Extend Work Opportunity Tax Credit
Washington – Today House Ways and Means Select Revenue Measures Subcommittee Chairman Mike Thompson (D-CA), Rep. Tom Reed (R-NY), Rep. Bill Pascrell (D-NJ), Rep Tom Rice (R-SC), and Rep. Tom Suozzi (D-NY) announced the introduction of H.R. 2213, a bill that permanently extends the Work Opportunity Tax Credit (WOTC) to help certain disadvantaged groups – including public assistance-dependent individuals, qualifying veterans, and persons with a physical or mental disability, among others – find permanent employment.
Washington, DC – Today, 36 members of the California Delegation sent a letter to Rep. Kevin Brady and Sen. Orrin Hatch, the chairmen of the House Ways and Means and Senate Finance committees, respectively, expressing deep concern about any proposed changes to the state and local tax (SALT) deduction as indicated in the "Big Six" framework. The SALT deduction allows taxpayers to deduct state and local taxes from their federal taxable income, and was written into the federal tax code since the inception of the income tax in 1913.
Washington, DC – Today, Congressmen Mike Thompson (CA-05), Bradley Byrne (AL-01), Derek Kilmer (WA-06), and Randy Hultgren (IL-14) introduced the Career Advancement Through New Skills Act, legislation that would incentivize employers to invest in their employees, giving them the necessary training to close the skill gap that exists between employers' needs and employees in many industries.
Washington, DC – Today, Rep. Mike Thompson (CA-05) issued the following statement following a meeting with the President and a bipartisan group of members of the House Committee on Ways and Means at the White House:
Press Democrat: Sonoma County's congressmen say President Trump's speech long on promises, short on details
Sonoma County's two members of Congress said President Donald Trump made expansive promises and talked about spending trillions of taxpayer dollars in a speech Tuesday night that was short on explaining how any of it will be done.
"He made a lot of lofty promises that quite honestly I don't see how they can be achieved," said Rep. Mike Thompson, D-St. Helena, in a telephone interview shortly after the president's first speech to a joint session of Congress.
U.S. Reps. Mike Thompson (CA-05) and John Garamendi (CA-03) announced that low-interest Small Business Administration loans have been made available to business owners and homeowners impacted by the Clayton fire.
While there are no official estimates as to how many businesses and homeowners are eligible to receive these loans, the owners of the 203 homes and eight commercial structures that were destroyed may be eligible to receive these loans should they choose to apply and meet SBA criteria.
WASHINGTON, D.C. (May 11, 2016) – The Small Business Council of America (SBCA), a national nonprofit organization which represents the interests of more than 20,000 privately-held and family-owned organizations on Federal tax, employee benefit and health care matters, presented its 33rd Annual Congressional awards on May 4, 2016.


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Add Your Business/Event
hotels close to the gay bars and clubs
hotels close to the most popular gay beach
hotel category:
For more hotel choices, click here to search all Mykonos hotels.
Mykonos is particularly busy in August-September. Popular hotels sell out fast, so book early.
exclusive rates, big discounts &
free cancellation on many rates
Hotels near Mykonos Town are close to the gay bars and nightlife in the Old Port area. Most are on the hillside, right behind the town centre, offering stunning sea views and warm breezes.
The gay nightlife in Mykonos starts late, with the bars filling up after midnight. Taxis are in short supply (and expensive) at night, so it is sensible to stay in this area.
Why this hotel? Gay hotel. Fabulous pool & bar scene. Free WiFi.
Mykonos' famous gay hotel Elysium offers spectacular views of Mykonos Town and the Aegean Sea, located a 15-minute walk downhill to the gay nightlife around the Old Port...
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Why this hotel? Fabulous pool & terrace. Close to gay nightlife. Popular choice. Free WiFi.
Great-value resort on the outskirts of Mykonos Town with beautiful views of the Aegean Sea. The gay bars, restaurants and chic shopping areas around the Old Port are just a 15-minute walk downhill...
| map |
Why this hotel? Quiet location. Close to gay nightlife. Great views. Free WiFi.
A popular choice on Travel Gay. The Poseidon has a fabulous location in a quieter part of town, overlooking the famous Mykonos Windmills, the sea, and less than 500 metres from the gay bars and dance clubs...
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Why this hotel? Close to Old Town. Free WiFi.
Constructed in traditional Cycladic style and offering fantastic views to the Aegean Sea, Riva Suites is among the best places to stay in Mykonos. These luxurious Mykonian suites are conveniently located at the old port, by the sea, only a few steps from the heart of the town, where gay bars, restaurants and shops are. The new port is at 2 km and the airport is at 3 km away...
Why this hotel? Excellent value. Stunning views. Popular choice. Free WiFi.
If there was such a thing as 'Mykonos style', then Vencia would be a shining example. Inside the white Aegean buildings are beautifully simple, comfortable guest rooms, each with a spectacular view from its balcony...
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Why this hotel? Chic luxury hotel. Near Mykonos Town & gay scene. Free WiFi.
The highly-rated Kouros boutique hotel is set on a cliff at the north end of Mykonos Town. The resort has panoramic views of Mykonos port, Delos Island and the Aegean Sea...
| map |
Why this hotel? Amazing views. Close to Mykonos Town. Free WiFi.
Located on the hillside immediately behind Mykonos Town, the Alkyon's pool terrace offers breathtaking panoramic views. Yet the hotel is just a 10-minute walk downhill to the town centre (perhaps 15 minutes to reach the gay bars)...
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Why this hotel? Great hillside location. Excellent value. Fabulous service. Free WiFi.
The consistently well-rated Hermes Mykonos has a fabulous hillside location, overlooking the Old Port and the Aegean Sea. The gay nightlife and restaurants in the Old Town can be reached in about 10 minutes on foot...
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Why this hotel? Seriously stylish. High quality. Scenic views. Great food. Free WiFi.
Care and money has certainly gone into building this beautiful hotel, which blends traditional Greek style with modern touches...
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Why this hotel? Walk to gay bars. Large villa-style rooms with beautiful sea views. Great value. Free WiFi.
Great-value, apartments in Mykonos Town. Little Venice Suites offers fantastic views of the Aegean Sea and the famous windmills...
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Why this hotel? Affordable comfort. Sun-soaked independence. Free WiFi.
Sahas Studios are 13 self-catered apartments in Tourlos, a few minutes' walk above Mykonos Town...
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Why this hotel? Top 100 hotels. Great location. Near Mykonos Town. Free WiFi.
Popular beachfront resort in beautiful location. The Mykonos Bay is situated on Megali Ammos Beach, about a 15 minute walk from the town...
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Why this hotel? Value for money. Great location. Close to Little Venice. Free WiFi.
Hotel Adonis offers affordable rooms, close to Mykonos Town centre, particularly 'Little Venice' with its wide range of bars and restaurants...
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Why this hotel? Fabulous location. Walk to gay bars, shops, restaurants in Mykonos Town.
Located just a short walk to Mykonos Town, the nearest beach and the main gay scene, Porto Mykonos Hotel offers modern, well-appointed rooms, a freshwater pool, a gym and a sauna...
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Why this hotel? Walk to the beach. Quiet location.
Great-value boutique choice in beautiful, quiet location in Mykonos town, close to the shops and restaurants...
| map |
Why this hotel? Close to gay nightlife. Fabulous views. Budget choice. Free WiFi.
Offering magnificent views of the Aegean Sea, the Portobello Boutique Hotel enjoys a surprisingly quiet location in Mykonos Town, just a few minutes' walk from the gay scene..
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Why this hotel? Fabulous view. Cycladic style. Quiet location. Free WiFi.
Great-value, Cycladic-style hotel located in a quiet area, within walking distance of the historic Old Town and gay nightlife...
| map |
Why this hotel? Walk to the beach. Excellent value. Near the city centre & gay scene.
Located in the heart of Mykonos, just about 5 minutes' walk from the beach. Elena Hotel offers great-value rooms with free WiFi a 24-hour front desk and a shared lounge...
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All but one hotel within walking distance of Elia Beach falls into our 5-star luxury category. The mid-range option is Sunrise Hotel which tends to get fully booked early in the season.
Why this hotel? Steps from the beach. Excellent restaurant. Free WiFi.
Elia Beach offers a choice of 12 comfortable rooms and 3 suites, just a short stroll from the gay beach area. They are managed by the same company that operates the Elia Beach Restaurant...
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Why this hotel? Private & peaceful. Stylish rooms. Short drive to Elia Beach Free WiFi.
Fabulous little hotel on the relatively secluded Kalo Livadi beach. From here, it is a 10-minute drive to Elia Beach and about a 20-minute drive to the gay nightlife in Mykonos Town...
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Why this hotel? Near Mykonos Town. Stunning views. Free WiFi.
Excellent resort in the south of Mykonos Town. The Myconian Korali's large, air-conditioned guest rooms feature comfortable beds, satellite TV, free WiFi, minibar, balcony with fabulous sea views...
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Why this hotel? Fabulous views. near Elia Beach. Great value. Free WiFi.
The excellent-value, no-frills Sea Side Studios & Houses is located in Kalo Livadi, about 2km Elia Beach and about 10 km from Mykonos Town...
| map |


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Back to Journals » Journal of Blood Medicine » Volume 8
The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits
Authors Kozlowski P, Montgomery S, Befekadu R, Hahn-Strömberg V
Received 5 December 2016
Accepted for publication 4 January 2017
Published 6 March 2017 Volume 2017:8 Pages 29—34
DOI https://doi.org/10.2147/JBM.S129516
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Martin H. Bluth
Piotr Kozlowski,1 Scott Montgomery,2–4 Rahel Befekadu,5 Victoria Hahn-Strömberg6
1Department of Medicine, School of Medical Sciences, Örebro University, Örebro, Sweden; 2Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; 3Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; 4Department of Epidemiology and Public Health, University College London, London, UK; 5Department of Transfusion Medicine, School of Medical Sciences, Örebro University, Örebro, Sweden; 6Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Background: Light chain amyloidosis (AL) is a rare deposition disease and is present in 10–15% of patients with myeloma (MM). In contrast to symptomatic AL in MM, presence of bone marrow (BM) amyloid deposits (AD) in MM is not connected to kidney damage. Renal AD but not BM-AD occur mostly in MM with lambda paraprotein (lambda MM).
Methods: We investigated amyloid presence in BM clots taken at diagnosis in 84 patients with symptomatic MM and compared disease characteristics in MM with kappa paraprotein (kappa MM)/lambda MM with and without BM-AD.
Results: Lambda MM with BM-AD was compared with kappa MM without BM-AD, kappa MM with BM-AD, and lambda MM without BM-AD: lambda MM with BM-AD patients had a significantly higher mean creatinine level (4.23 mg/dL vs 1.69, 1.14, and 1.28 mg/dL, respectively) and a higher proportion presented with severe kidney failure (6/11 [55%] vs 6/32 [19%], 1/22 [5%], and 3/19 [16%], respectively). Proteinuria was more common in lambda MM with BM-AD patients compared with kappa MM without BM-AD patients (8/11 [73%] vs 5/32 [16%], respectively).
Conclusion: Kidney damage was more common in lambda MM with BM-AD indicating presence of renal AD.
Keywords: plasma cells, neoplasms, amyloidosis, renal insufficiency, proteinuria
Light chain amyloidosis (AL) is a rare disease with deposition of amyloid fibrils containing light chains produced by nonproliferative clonal plasma cell (PC), causing mostly renal damage. The disease can also affect other organs such as the heart, and the gastrointestinal tract and peripheral nervous system.1,2 The main symptom of kidney damage in AL is proteinuria (73%), which when excessive (>3 g/24 h or >2 g/L) gives rise to nephrotic syndrome (36% of AL patients).1 Renal function impairment in AL is present in 50%, and severe renal failure, defined as creatinine >2.0 mg/dL, in 20% of patients.1 Concomitant AL in myeloma (AL-MM) is observed in 10–15% of patients.3 Renal disease in MM, when verified by kidney biopsy, is caused by amyloid deposits (AD) in 21–30% of patients.4–6 Renal function impairment is present in 50% (severe in 20%) of all MM patients at diagnosis.3
The standard diagnostic procedure in AL is a tissue biopsy of the affected organ or fat-pad biopsy.
Bone marrow (BM) amyloid deposits (AD) in AL are found in 60–65% of patients.2,7 Presence of BM-AD in MM is reported in 22–40% of patients8,9 and is more common than "true" symptomatic AL-MM. The former has no impact on survival and no connection with organ damage8,9 in contrast with AL-MM where survival is clearly impaired compared with MM without symptomatic AL.10 A recent study indicated that BM-AD in MM were present in only 1% of patients.11 In systemic AL1,2,7 and kidney biopsy-proven AL-MM,4 a clear dominance of lambda chain restriction (70–80% of all cases) is observed. This is compared with MM with BM-AD or fat-pad AD where lambda restriction is less common at 42% or 36%, respectively.8,12
Both MM and systemic AL are caused by clonal PC. Their features and proportion in BM though differ in both diseases as abnormal PC and abnormal PC aggregates are common in MM13 but not in AL.7,13 The BM PC count in AL is often low, with three quarters of patients having <10%7 compared with a mean PC count of 50% in MM.3
Previous studies of BM-AD did not evaluate its clinical significance in MM with kappa paraprotein (kappa MM)/lambda paraprotein (lambda MM) separately. This is why we used BM samples from MM patients taken at diagnosis to identify patients with amyloid presence and then we compared the disease characteristics in kappa/lambda MM with and without BM-AD. We postulated that patients with lambda MM and BM-AD are at higher risk to have kidney damage.
Patients, materials and methods
All patients with symptomatic MM diagnosed and treated at the Department of Medicine of Örebro University Hospital during 2000–2005 were identified through the hospital register. The treatment was given in accordance with the Swedish national guidelines. Patients under 70 years of age and without significant comorbidity were recommended to undergo autologous stem cell transplantation (ASCT). BM aspirates taken at diagnosis from posterior iliac crest were retrieved. Congo red staining for BM-AD presence and immunocytochemical staining were performed on formalin-fixed and paraffin-embedded BM particle clots. Congo red stain was considered as positive when vascular or interstitial deposits with cherry-red appearance (light microscopy) and apple-green birefringence (polarizing microscopy) were present. The biomedical scientist/hematologist assessing BM samples was blinded to the patients' clinical details. PC count, presence of PC atypia and PC aggregates in BM were described at MM diagnosis by a pathologist.
Clinical/laboratory data were collected retrospectively from patients' medical records. Presence of monoclonal protein in serum/urine and kappa/lambda characteristics was assessed by immunoelectrophoresis and immunofixation. Non-Bence Jones (BJ) proteinuria was calculated by subtracting BJ protein from total urinary protein. The date of last follow-up of the survivors was the 5th of September, 2015. The study was approved by the Regional Ethical Review Board in Uppsala, Sweden, (2011/356), in accordance with the Declaration of Helsinki, and written informed consent was obtained from all of the patients.
Cross-tabulation with the Chi-squared test or means with the two sample t-test were used for descriptive statistics. Multiple linear regression was used for outcome variables with continuous distributions. Creatinine levels were logarithmic transformed as they deviated from normal distribution [ln(creatinine–0.3929236)]. Binary outcomes were assessed using multiple logistic regression. The analyses of creatinine level and proteinuria were adjusted for age, sex, calcium level and presence of BJ proteinuria (>0.26 g/L). The analyses of albumin level were adjusted for uninvolved immunoglobulin level >4 g/L, M component <25 g/L and presence of light chain MM. The log-rank test was used for overall survival (OS) comparison.
Statistical significance was set as P-value <0.05 or 95% confidence interval (CI) that does not include 1.00 (logistic regression) or 0.0 (linear regression). The analyses were performed using SPSS (v.22; IBM).
A total of 108 patients with symptomatic MM diagnosis were identified. BM particle clots were available in 89. Three patients with kidney biopsy verified AL, and one patient with nephrotic syndrome and suspected AL was excluded, as well as one patient with nonsecretory MM. The median age in the remaining 84 patients was 70 years (range: 44–93). Beta-2 microglobulin and BM cytogenetics were assessed in a minority of patients. ASCT was performed in 24 patients. Most of the non-transplanted patients (51/60, 85%) received an oral melphalan and prednisolone combination (MP) as frontline therapy, two received MP plus thalidomide, three a thalidomide/prednisolone combination and four a vincristine/doxorubicin/dexamethasone combination (VAD regimen). Novel agents (thalidomide, bortezomib, lenalidomide) were used in 40 of 84 (48%) patients at diagnosis, disease progression or relapse. The patients' characteristics are shown in Table 1.
BM-AD findings and clinical characteristics
BM-AD was found in 34 of 84 (40%) patients at diagnosis. Of all clinical/laboratory parameters (listed in Table 1), only presence of hypoalbuminemia (serum albumin <3.5 g/dL) differed between BM-AD-positive and BM-AD-negative patients (18/33 [54%] vs 44/51 [86%]; odds ratio [OR] 0.19, 95% CI: 0.07, 0.55; P = 0.002; and adjusted OR 0.13, 95% CI: 0.04, 0.46; P = 0.001). Mean albumin level was higher in BM-AD-positive patients (3.29 g/dL [standard deviation, SD 0.70] vs 3.01 g/dL [SD 0.55]), and when assessed using multiple linear regression, the association was as follows: unadjusted coefficient −2.83, 95% CI: −5.55, −0.11; P = 0.042; and adjusted coefficient −3.22, 95% CI: −5.79, −0.66; P = 0.014. Heart failure was present in five and peripheral neuropathy in only two patients at diagnosis. The latter developed during the treatment in nine patients, all treated with potentially neurotoxic drugs. Alkaline phosphatase and alanine aminotransferase levels were raised (moderately) in only two patients at diagnosis.
BM-AD findings, renal damage, and survival
Neither presence of BM-AD at diagnosis nor kappa/lambda characteristics were associated with higher creatinine levels. In order to investigate the significance of BM-AD in both light chain types of MM, four groups were constructed (Tables 1 and 2). Renal failure at diagnosis (creatinine >2.0 mg/dL) and need for dialysis (six patients at diagnosis and two at follow-up) were most common in the group with lambda MM and BM-AD presence (Table 1).
Presence of non-BJ proteinuria (>0.2 g/L) was more common in lambda MM with BM-AD compared with kappa MM without BM-AD (Table 1). Assessment by multiple logistic regression produced ORs of 13.88 (95% CI: 2.70, 71.20; P = 0.002) before adjustment and 24.22 (95% CI: 3.60, 162.82; P = 0.001) after adjustment. Among patients with severe renal failure (16), all six with lambda MM with BM-AD presented with non-BJ proteinuria compared with five of nine (56%) remaining patients (one had anuria) (P = 0.09). Urine albumin-to-creatinine ratio (UACR) measurement was performed in 59 patients. Four of eight patients (50%) with lambda BM-AD-positive lambda MM presented with UACR >15 compared with three of 23 (13%) with BM-AD-negative kappa MM, producing unadjusted OR using logistic regression of 6.67 (95% CI: 1.06, 42.06; P = 0.04). The proportion of BM-AD-positive kappa MM and BM-AD negative lambda MM was 5/17 (29%) and 5/11 (45%), respectively (nonsignificant as compared with BM-AD-positive lambda MM). There was no association between albumin level and presence of proteinuria (>0.2 g/L) or between albumin level and UACR >15.
Compared with lambda MM with BM-AD, the other three phenotypes were all associated with statistically significant lower creatinine levels, both before and after adjustment for the potential confounding factors (Table 2). In multivariate analysis, creatinine level was positively associated with albumin-adjusted calcium level, BJ proteinuria >0.26 g/L and male sex (Table 2). Survival was not associated with presence of BM-AD, and in lambda BM-AD-positive MM, did not differ significantly from OS in the remaining three groups (data not shown).
BM-AD and cytopathological features
PC atypia was slightly more common in BM-AD-negative patients (48/51 [94%] vs 27/33 [82%], P = 0.08]. There was no significant correlation between presence of BM-AD at diagnosis and BM PC count. Proportion of patients with abnormal PC aggregates was not different in AD-positive and AD-negative BM.
We identified AD in BM clots in 40% of MM patients at diagnosis, which is similar to previous findings in BM smears.8 Particle clot preparation is commonly used in Sweden and is sometimes advantageous as proteins and nucleic acids can be damaged during a decalcification procedure of the biopsy.14 This may explain the lower frequency of AD in BM biopsy (25%) compared with BM aspirate (40%) in previous studies.8,9 There were no differences (except albumin level/hypoalbuminemia) in laboratory/clinical characteristics of the two groups with and without presence of BM-AD, similar to the results from previous studies.8,9 Despite this, we identified a small but distinctive group of patients with lambda MM and BM-AD presenting with higher mean creatinine levels, more common kidney failure (nearly 60% had severe renal failure at diagnosis) and need for dialysis, with more pronounced proteinuria and albuminuria. This indicates that "true" renal amyloidosis was probably more common in this group. Conversely, kidney damage was rare in kappa MM without BM-AD.
There are differences in the pathogenesis of kidney damage in lambda and kappa MM. AL was found to be more common in lambda (80%) and monoclonal immunoglobulin deposition disease (MIDD) and even MM-cast nephropathy (MCN) in kappa MM among patients undergoing renal biopsy.4–6 Twenty-four-hour proteinuria was significantly higher in MM-associated amyloidosis compared with MIDD and MCN. Nephrotic syndrome in MM was caused by amyloidosis in 54–70% of patients.4,5 In our cohort, all patients with BM-AD-positive lambda MM and severe renal failure had proteinuria, in contrast to only half of the remaining patients with severe renal failure, suggesting different causes of renal damage.
Not all AL-MM can be identified using BM Congo red stain, as even in systemic AL, BM-AD was not present in 35–40% of patients.2,7 Interestingly, creatinine levels in systemic AL with BM-AD were higher compared with those without BM-AD.2 Even multi-organ involvement was more common in the former group.2 Both findings indicate more advanced amyloidosis when BM-AD is present. Renal and cardiac amyloidosis was more common in lambda AL compared with kappa, and the association of different subtypes of light chain variable region genes with different organ tropism was observed previously.15
Perhaps surprisingly, albumin levels were lower in BM-AD-negative compared with BM-AD-positive patients. This is unlikely to be explained by urinary protein loss, as albumin levels did not differ between patients with presence/absence of proteinuria/albuminuria. Low albumin is recognized as a poor prognostic factor in MM3 and probably indicates more aggressive disease.
Another difference between BM-AD-positive and BM-AD-negative disease, suggesting the involvement of different biological processes, is that PC atypia was slightly less common in the former group. This is consistent with the "normal" appearance of PC in AL.7 There was no difference in mean PC count in BM between AD-positive and AD-negative phenotypes in our cohort, although lower mean PC infiltrate level was demonstrated previously in renal AL-MM compared with other nephropathies in MM.4
Similarly to a previous report,8 we did not identify any survival disadvantage in patients with BM-AD. AD findings in fat-pad biopsy in MM are considered a poor prognostic factor (even when subclinical)16 but not when ASCT is performed.12 Thus, the prognostic significance of extra-renal AD remains uncertain. In spite of this, diagnosing symptomatic AL, especially in younger MM patients, is crucial as the treatment-related toxicity and mortality is higher for systemic AL compared with MM in an ASCT setting.17 Even tolerability to novel agents such as thalidomide is poorer in systemic AL.18,19 The prognosis in AL-MM remains dismal with median survival of only 9.1 months from AL diagnosis.10 Renal biopsy is not always possible in frail MM patients especially those with a bleeding tendency. Combining fat and BM biopsy in AL could increase disease detection to 96%.7 Simultaneous assessment of kappa/lambda ratio in serum and in urine can indicate renal amyloidosis in MM.6
Our study has some potential limitations. The number of lambda MM patients with BM-AD was small. Albuminuria was not measured in all patients. Assessment of AD in BM can be difficult as indicated by the discrepancies between studies of AD-BM prevalence in MM.8,9,11 Creatinine level is not the most reliable renal function measurement, but this was all that was available for the majority of our patients.
We confirmed that BM-AD in MM is a relatively common finding, but in contrast with conclusions from other studies, it may have clinical significance. The more prevalent renal disease in lambda MM with BM-AD suggests there could be two separate types of MM-associated BM amyloidosis (possibly even in fat tissue): kappa, predominantly without organ involvement, and lambda signifying "true", systemic amyloidosis mainly causing kidney damage.
The identification of BM amyloid in MM should be assessed together with clinical presentation, light chain type and probably fat-pad biopsy. For a certain diagnosis, biopsy of the affected organ remains the gold standard. Higher albumin levels in patients with BM-AD and slightly less frequent PC atypia suggest that biological processes in MM with and without BM-AD may differ.
This study was supported by grants from the Research Committee of Region Örebro County Council (Örebro, Sweden).
The authors report no conflicts of interest in this work.
Kyle RA, Gertz MA. Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Semin Hematol. 1995;32(1):45–59.
Cowan AJ, Seldin DC, Skinner M, et al. Amyloid deposits in the bone marrow of patients with immunoglobulin light chain amyloidosis do not impact stem cell mobilization or engraftment. Biol Blood Marrow Transplant. 2012;18(12):1935–1938.
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Montseny JJ, Kleinknecht D, Meyrier A, et al. Long-term outcome according to renal histological lesions in 118 patients with monoclonal gammopathies. Nephrol Dial Transplant. 1998;13(6):1438–1445.
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Siragusa S, Morice W, Gertz MA, et al. Asymptomatic immunoglobulin light chain amyloidosis (AL) at the time of diagnostic bone marrow biopsy in newly diagnosed patients with multiple myeloma and smoldering myeloma. A series of 144 cases and a review of the literature. Ann Hematol. 2011;90(1):101–106.
Desikan KR, Dhodapkar MV, Hough A, et al. Incidence and impact of light chain associated (AL) amyloidosis on the prognosis of patients with multiple myeloma treated with autologous transplantation. Leuk Lymphoma. 1997;27(3–4):315–319.
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Lee SH, Erber WN, Porwit A, Tomonaga M, Peterson LC; International Council for Standardization in Hematology. ICSH guidelines for the standardization of bone marrow specimens and reports. Int J Lab Hematol. 2008;30(5):349–364.
Abraham RS, Geyer SM, Price-Troska TL, et al. Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL). Blood. 2003;101(10):3801–3808.
Vela-Ojeda J, García-Ruiz Esparza MA, Padilla-González Y, et al. Multiple myeloma-associated amyloidosis is an independent high-risk prognostic factor. Ann Hematol. 2009;88(1):59–66.
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By JASON McGINNIS
Merry Christmas from all of us here at NeoNova!
As you can see, I've already received some presents under my office tree, and they're just what I always wanted.
If you've ever joined us for one of our annual Summits, you know they're a great mix of actionable info, peer networking, and a whole lot of fun. We love seeing our Affiliates each year and sharing ideas to help us all succeed, but we realized it might be time to introduce some fresh new ideas and connections. So, we're thrilled to announce that we're partnering with our parent company NRTC and sister company Telispire to throw the end-all, be-all of summits! It'll be three times the innovation and three times the fun.
We're still working on a catchy name for this event, but we wanted to share the details as soon as possible:
What: Summit 2017 with NeoNova, NRTC and Telispire
Where: Jekyll Island, Ga.
When: Nov. 14-17, 2017
I know our last Summit in Jackson Hole was a bit on the cold side, and you might be eyeing that November date with a little shiver. Not to worry … the average temperature the week we're going is more than 70 degrees! By the way, if you've never been, Jekyll Island is absolutely beautiful. I put together a little collage below to share some of the sights. We're pretty excited about this one.
Please mark your calendars, and I really hope you can join us. In the meantime, I'm happy to talk with you about any services we provide, brainstorm new product ideas or other ways we can help, or just about anything else. You can call my cell (919.800.7465) or email me at email@example.com.
On behalf of our family here at NeoNova, I'd like to wish you and your family a very Merry Christmas and Happy New Year!
– McG
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A: Saint Nickel-less!
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A: Tinselitis!
Ok, I better stop before the laughter hurts your sides too badly. Once again, have a Merry Christmas and a Happy New Year!


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In Good Company and Pseudoephedrine
A Winning Combination
When I'm getting over a cold, I like to see romantic comedies. It's part of my reintegration into society, after spending several days hiding and horizontal, watching Moment of Truth movies on Lifetime and abusing Thera-Flu®. When I finally have the energy to leave the house, I don't want to be mentally challenged. I need to be totally healthy to see Rwanda genocide biopics or whatever turgid masterpiece is out at the moment. In a sore-nose and phlegm-spitting state, I need to be soothed by the vapidity of jokes based on 1970s-era notions of gender difference, of characters created by Warner Brothers' Random Cliché Generator 9000 and of the tried-and-true romantic-comedy plot: boy meets girl, boy and girl break up over silly misunderstanding, boy and girl get back together, boy makes publicly humiliating apology-cum-marriage proposal.
With this in mind, and with my third cold of the season going into remission, I went to see In Good Company. Based on the trailer, which told me that twenty-six-year-old Topher Grace is fifty-one-year-old Dennis Quaid's new boss in some anonymous suit-and-tie company, I was expecting The Secret of My Success: Part Two. (And I was hoping for gratuitous butt shots of Dennis Quaid.) I'm sure you all remember that cheery Michael J. Fox vehicle about the mailroom guy who moves into an empty office and starts wearing suits and talking in MBA-ese, thus conning his way into the executive boardroom and Helen Slater's panties. I loved that movie as a kid, just as I loved all those neo-Madison Avenue movies from the 1980s: 9 to 5, Big and Working Girl. These movies all had the same-classically American-plot: through reinvention, self-reliance and lies, the underdog can make it in big business.
These movies all had the same-classically American-plot: through reinvention, self-reliance and lies, the underdog can make it in big business.
Nowadays, that theme isn't terribly popular. The big office comedies are more like Office Space, in which the underdog vocally refuses to follow the capitalistic path and drops out. In 13 Going On 30 (Big with a girl), Jennifer Garner loses the climactic business contest to the bitchy corporate thief-and quits. In Zoolander, Ben Stiller starts a literacy centre when he discovers that the fashion industry is corrupt. Basically, capitalism, according to Hollywood, isn't trendy anymore. This is ironic because Hollywood is perhaps the most appallingly money-driven, unethical and Darwinian industry-besides pop music-in the United States.
I probably only noticed this trend during In Good Company because I was expecting The Secret of My Success and I got The Anti-Globalization Manifesto. No, the movie isn't about Che T-shirts and WTO protests. It's about a middle-aged man (Quaid) who sells ads for a magazine just like Sports Illustrated. When the magazine is sold to a company that is a cross between News Corp. and Microsoft, he's demoted and a twenty-six-year-old whiz kid (Grace) is installed as his boss. The whiz kid uses words like "synergy" and has no idea what he's doing. The middle-aged man has twenty-year-long relationships with clients and "believes" in the magazine. The whiz kid has no emotional life; his wife leaves him the day he arrives at his new job. The middle-aged man has a fabulous wife (Marg Helgenberger) and two lovely daughters, one of whom is a tennis star and wants to be a writer. The whiz kid falls in love with her.
The wannabe writer is played by Scarlett Johansson and is supposed to be the polar opposite of the whiz kid's ex-wife, a depressed dullard barely brought to life by Selma Blair. But Johansson plays every role as a depressed dullard, so all you can take from the whiz kid's romantic choices is that he's got fucked-up taste. Well, that and his interest in the writer shows how he's becoming a better person, someone more like the middle-aged man. Predictably, when the middle-aged man finds out his boss is boinking his daughter, all hell breaks loose. The middle-aged man slugs the whiz kid and makes a speech, during the head of MicroNewsSoftCorp's visit to the magazine, that is something like a cross between "I'm mad as hell and I'm not going to take this anymore!" and "Have you no sense of decency...?" Actually, wait. That's wrong. I just wish the speech had been like that. It was actually quite dull, even if the point was admirable.
I have an incredibly soft, tender, almost bruised spot in my heart for Dennis Quaid. His charming, tough-yet-sensitive salesman was a moving creation. I know men like him; they're not that hot, but they are that good.
Rereading what I've written so far, it may appear that I didn't like the movie. Actually, I enjoyed it quite a bit. I have an incredibly soft, tender, almost bruised spot in my heart for Dennis Quaid. His charming, tough-yet-sensitive salesman was a moving creation. I know men like him; they're not that hot, but they are that good. And Topher Grace is not a joke waiting to happen. He's not just another teen star with good publicists and no talent, like Joshua Jackson or Hilary Duff. Grace is Tom Hanks waiting to happen, a gifted comic actor who can be funny and sad and real. He's not a ham, he's a natural. His transformation from someone who would win on The Apprentice to someone who has a soul, while a clichéd process, was lovely and-um, this could be the cold medicine making me feel this way-downright touching.
I just wish that these complex characters, and not a deus ex machina, had resolved the movie. About a minute after Dennis Quaid goes all Revolutionary Road-well, I won't give it away. But it might as well have been a black screen with "then a miracle occurs" typed across it. Of course, romantic comedy and lottery-level wish fulfillment go together like Tom Hanks and Meg Ryan. Wanting a true-to-life ending must have meant that I was feeling better.
Ted Gideonse has written about the arts (and other stuff) for Newsweek, Rolling Stone, Salon and the Advocate. He lives in Brooklyn and keeps a blog, the Gideonse Bible. Bring Me the Axe appears every other Friday.