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Re-union (Poem)
Since that drear day that took you from my sight.
And left me in a world grown strange and cold,
One anchoring thought has made my spirit bold,
One star has shed its ray across my night.
'Tis this—that how so e'er I miss the light
Of your dear smile, the pressure of your hand,
Each hour but brings me nearer to that land
Where sundered lives once more shall re-unite.
O dawn no earth-born clouds can ever mar,
O Spring more fair than those of time can be,
O Vision set impregnable, afar,
By night and day I journey on to thee;
And when at length I reach that hour supreme,
How trivial will appear life's tangled dream.
More in this issue« The Editor's Letter Box | Review »
Related items
More from Margaret E. Ford
Margaret E. Ford
Little is known about this author. If you have information about this author to share, please contact me.


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Being a responsible citizen in our community
Working together for excellence
Aspiring to be our best
Treating others as we wish to be treated
Welcome to High Crags Primary Leadership Academy
Latest NEWS
Pupils in the good books for Pyjamarama
Pupils and staff spent the day in their pyjamas as part of BookTrust's campaign to give every child a bedtime story. The school joined thousands up and down the country in the Pyjamarama event, where participants each donated £1 to support the work of the charity...
School judged 'good' with 'outstanding' early years provision in Ofsted inspection
Our staff, pupils, parents and governors are celebrating after we were judged by Ofsted to be 'good' overall with 'outstanding' early years provision, after previously being judged as inadequate in its last Ofsted inspection in 2015. An Ofsted inspection team visited...
Pupils feel the funny to raise money for Comic Relief
It was a day of fun and games as pupils fundraised for Comic Relief. The school council organised a range of Red Nose Day events throughout the day to raise both money for, and awareness of, Comic Relief. Pupils marked the day with a 'wear red' non-uniform day with...
progress rating in Writing
Educational Excellence
leadership academies a week
Character Development
raised for charity

subset: commoncrawl


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Can an individual withdraw its consent for processing personal data? If yes, how it can be done? Are data controllers ready for such option? All these questions became very topical upon adoption of amendment to the Polish data protection regulations.
The main Polish regulations regarding processing of personal data are contained in the Personal Data Protection Act of 1997 (hereinafter: PDPA) that implements Directive 95/46 into Polish law. Generally, personal data is processed on the basis of consent given to data controllers by the person whose data are processed. Hence, rules regarding consent are crucial for all those who are involved in data processing. The latest amendment to the PDPA provides a small but significant change to the existing regulations. As such it is certainly worthy of blog subscribers' attention.
Until now, one of the main controversies related to the issue of consent under PDPA was connected with the possibility of withdrawing consent for processing data. The regulations have not expressly provided any mechanism for an individual to withdraw consent. Although the possibility of withdrawing consent was widely approved, divergent opinions have also been presented.
One of the aims of the amendment to the PSDA that was adopted by Parliament on 24 September 2010 was clarifying the issue related to withdrawal of consent. The amendment to article 7 point 5 of PSDA expressly provides that consent for processing personal data can be cancelled by an individual at any time. According to the justification to the draft amendment, due to the ambiguous interpretation of "consent" in judicial doctrine, the proposed amendment clearly provides that it is permissible to withdraw (cancel) consent.
Most of the market participants that expressed their views and remarks to the draft amendment stated that introducing clear and unambiguous regulations permitting withdrawal (cancellation) of consent to process personal data are necessary and desired. However, some commentators raised the lack of detailed rules regarding cancellation of the consent in the draft amendment.
The impact of the amendment may be significant. Existing data processing infrastructure must be adopted in order to allow for effective cessation of data processing upon receipt of an individual's cancellation. This would probably require IT adjustments and adoption of new internal procedures.
Since the amendment is so brief, it seems to only partially solve old controversies. The amendment is clear in a way that it gives individuals the right to withdraw consent at any time. However, some important questions still remain unanswered. First and foremost, no form of cancellation is determined. Therefore, it is not clear what kind of statement would suffice for cancellation. Does the answer depend on the form of original consent? It is not determined when the cancellation is treated as being sufficiently delivered to the addressee? Who should be the addressee of the cancellation? Who is bound by the cancellation? What are the obligations of the data controller upon receipt of the cancellation? Can the consent be cancelled only partially (e.g. in respect of specific territory)?
Amended Polish regulations do not provide clear answers to these questions. Needless to say such a situation creates a significant risk for data controllers. Processing data despite cancellation of consent means that such data are processed illegally. All the above questions must be answered in the near future. Hopefully, Polish data protection authorities will provide some interpretations in this respect.
All experiences from other jurisdictions are welcomed.


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Take part in the Weird Fish Clothes this month and every month just by giving your email address. One lucky winner will receive a £250 giftcard every month which could buy you a whole new wardrobe of their superb casual clothing including kids, holiday and outdoors clothing. Its free to take part, just fill in your email to take part.
As a member of their free email newsletter you get access to exclusive offers, deals, advice and style tips. Its for members only but you can join at any time. It only takes a few seconds to join, so sign up now. Mums, dads, children of all ages will love these tough styles. Nautical, beachwear, lounging or setting out on holiday these clothing items will do it all.
To win £250 of trending family fashion enter today. Its free and there are so many other reasons to join the Weird Fish Clothes email newsletter. One winner will be picked out the hat each month. If you do not take part you wont win, and you wont be saving money on your family fashion either!
If you havent checked out this popular store then what are you waiting for? Durable and cool clothing that you will love to wear every day. Up to 5XL and down to kids sizes are available.
Enter the free Weird Fish Clothes monthly draw now, you have a chance to win each month. You can choose to leave any time with no obligation at any time. It could pay for a full set of clothing for everyone in your household! Another great way to win brought to you by UK Competitions, the home of winners since 2001. There are 100's of other competitions, free bet offers and games to choose from 7 days a week. All provided free of charge to our members.


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Position Purpose:
The Staff Accountant must be flexible, able to multi-task and be a self-starter. The Staff Accountant will perform general accounting functions and will take direction from management to deliver results in a professional and positive manner.
Major Tasks, Responsibilities and Key Accountabilities:
• Prepares monthly bank reconciliations
• Accounts Receivable using appropriate posting procedures
• Reviews and prepares monthly Financials for Homeowners' Associations
• Maintains GL's for separate Homeowners' Associations
• Provides detailed analysis/reports on Homeowners' Associations as required
• Completes special assignments as requested by CFO
Minimum Qualifications
• Must be eighteen years of age or older
• Must pass a Drug Test
• Must pass a Background Check
Experience Required
• Bachelor's Degree in Accounting preferred, but equivalent and/or completion of accounting courses may be accepted
• Detail-oriented, highly accurate and well-organized individual
• Excellent communication and interpersonal skills
• Working knowledge of GL's
• Proficiency using Microsoft Office applications and Outlook
Education Preferred
• Proficiency using Accounting Software
• Bachelor's Degree preferred
Experience Required
• A minimum of 3 to 5 years working experience in accounting
To be considered, please email your resume and cover letter to firstname.lastname@example.com


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Tips For Surviving The First Holiday Season Following A Divorce
Going through a divorce is challenging at any time of the year, but it can be especially difficult during the holiday season.
For recently divorced individuals, the holidays can bring into focus many emotional (and financial) challenges that they may not have recognized before, such as missed family traditions, dividing time with the kids, the financial challenges of gift giving and the stress of event planning. I believe the key to navigating this difficult "first" is in taking the time to evaluate and articulate what's truly important about the holidays, and making decisions to preserve the spirit of the season.
For more than two decades, I have worked with clients to help them navigate both the emotional and financial aspects of life transitions, and I have noticed that the holiday season is an especially difficult time for those experiencing a major life change. If you are facing the holidays after a divorce, I hope the following tips will help you find joy in your "new normal."
Find Joy in New Traditions
Holiday traditions create treasured memories that last a lifetime. It's often difficult to let go of traditions after a divorce, but it is also a great opportunity to evaluate what is truly important to you and create new traditions accordingly. Did your ex-spouse make a fabulous Christmas meal, but you can hardly boil water? Order carry-out from a local restaurant and have a picnic next to a roaring fire. Missing the hustle and bustle of a house full of people? Invite friends over. Having everyone bring food to share creates an instant party with little hassle and time to spend with each other.
Know that it's Not the Actual Day that Matters
The holiday is not defined by a specific date on the calendar. It's time spent with your loved ones that truly matters. Try to keep this in mind if your children are spending the holiday with your ex. Celebrating before or after the actual holiday can give you more time together without having to shuffle to family members' events. But, don't spend the actual day alone, either. Make a plan in advance to spend the holiday with family or friends. Have a friend who has also gone through a divorce? Reach out to see if she has room for one more at her holiday table. Even if she has her kids with her this year, you may be able to return the favor in the future. (New holiday traditions, remember?)
Give the Gift of Time
Another challenge many recent divorcees face is not being able to spend as much on holiday events and gifts as in previous years. Again, it's all about focusing on what's most important during the holiday season. Did your past holiday traditions include an elaborate Nutcracker performance with the kids? Many local dance studios and community colleges put on excellent performances for a fraction of the cost. Are your children used to extravagant gifts under the tree? Talk to them in advance about what they can look forward to and what not to expect. Planning the holiday together and getting on the same page can make a big difference. Focus on the gift of spending time together.
The holidays are an emotionally charged time for many of us, but they are also a time to count our blessings and spend time with those we love. Be patient with yourself and find joy where you can. After all, a new year is about to begin, and with it a fresh start and endless new possibilities.
Happy holidays!
The views expressed are for commentary purposes only and do not take into account any individual personal, financial, or tax considerations. It is not intended to be personal legal or investment advice or a solicitation to buy or sell any security or engage in a particular investment strategy.
Mariner, LLC dba Mariner Wealth Advisors ("MWA"), is an SEC registered investment adviser. Registration of an investment adviser does not imply a certain level of skill or training. MWA is in compliance with the current notice filing requirements imposed upon registered investment advisers by those states in which MWA maintains clients. MWA may only transact business in those states in which it is notice filed, or qualifies for an exemption or exclusion from notice filing requirements. Any subsequent, direct communication by MWA with a prospective client shall be conducted by a representative that is either registered or qualifies for an exemption or exclusion from registration in the state where the prospective client resides. For additional information about MWA, including fees and services, please contact MWA or refer to the Investment Adviser Public Disclosure website. Please read the disclosure statement carefully before you invest or send money.


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Pregnant before first period after miscarriage
I miscarried at 5 weeks on November 24th. I saw my doctor and he said we were fine to start trying again and next cycle I should track for him. He said if we got pregnant before my first cycle it wouldn't be a problem especially because my hcg level was back to almost 0 but we were still planning to wait one cycle. We weren't preventing but weren't trying and we honestly didn't have sex much at all. So yesterday since I still hadn't started I took a test just to be sure I wasn't and all 4 tests were very positive. So obviously we are extremely excited and nervous. Anyone else have similar experiences??


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Start here
Once you determine which antenna you need, then go to the retailer and compare antennas. I would avoid ebay unless you understand how antennas work.
You could also look at some of the links I have posted in earlier posts on this thread. Also, there is nothing special required by an antenna to receive a digital signal. Antennas do not have to have any special design for digital or HDTV.


text: Join us for the next event in our series of summer workouts at local breweries to benefit the YMCA's Annual Campaign Calendar Add to Calendar Add to Timely Calendar Add to Google Add to Outlook Add to Apple Calendar Add to other calendar Export to XML When: July 13, 2019 @ 10:45 am – 11:45 am America/Indiana/Indianapolis Timezone 2019-07-13T10:45:00-04:00 2019-07-13T11:45:00-04:00 Where: Centerpoint Brewing 1125 E Brookside Ave Indianapolis, IN 46202 USA Cost: $15 donation per person Contact: Erika Burcher 317.685.9705 Email Irsay Family YMCA at CityWay YMCA at the Athenaeum YMCA at the City Market BodyPump brewing centerpoint fundraiser LesMills workout LesMills BodyPump is a barbell workout for anyone looking to get lean, toned and fit – fast. Using light to moderate weights with lots of repetition, BodyPump gives you a total body workout. Instructors will coach you through the scientifically proven moves and techniques pumping out encouragement, motivation and great music – helping you achieve much more than on your own! You'll leave the class feeling challenged and motivated, ready to come back for more. $15 gets you a workout, your choice of a brew and benefits the YMCA's Annual Campaign, which helps people afford YMCA memberships and programs through scholarships. Must be 21 years or older to register and attend. Participants can sign up for these classes through the MINDBODY app one starting July 6 to hold your spot. Registered participants will pay via cash or credit upon arrival at Centerpoint on July 13.


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Lagos International Food And Beverage Fair focuses on the whole food and beverage value chain.
Lagos International Food And Beverage Fair focuses on the whole food and beverage value chain.
International logistics fair - the first international logistics fair of
its kind and the largest logistics fair in the larger region.
Nigeria's 5th International Trade Show - Agriculture - Food Processing, Packaging, Bakery & Confectionery Technology – Ingredients – Food & Hospitality
26 - 28 March 2019
The FOODEXPO is part of ELANEXPO's international portfolio of Food and Hospitality event.
Morocco CBHExpo will host companies representing the entire cosmetics and Hygiene supply chain: Cosmetic & Hygiene products and ingredients, private label and packaging.
An expanding economy and growing demand for investment outside in Azerbaijan are the driving forces to organize the 4th edition of Azerbaijan Rec Expo which is the country's only and the first inte
The long awaited International Refrigeration, Ventilation, Air-Conditioning & Heating events, MEGA CLIMA will be launched in Nigeria, Iraq and Kenya annually.
There is no media available at this time.


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Pennsylvania Vacation Activities
Pennsylvania Regions
3 Vacation RentalsYour Favs ()
sort by
Lakeside Country CottagesLake Wallenpaupack: Cabin2 BDR • 1 Loft • 1 Den • 1 BA • Sleeps 6 • #230235138 to 190 USD/nightOur rustic cottages are located around the lake Wallenpaupack in some 2 min walk-down. We are not a luxury property, we are suitable for those who are looking for a quiet, affordable getaway in a "camping cabin" which has all necessary amenities. There are 15 cabins available for rent, so if you're looking for more than one please let us know. Also, please note that some cabins may have a sofa bed in the living room, while others may have a futon.
Pet Friendly - LakefrontKingsley: Cottage2 BDR • 2 BA • Sleeps 8 • #247624201 to 257 USD/nightThis is a cottage on a private lake 25 miles north of Scranton PA - just a 2 to 3 hour drive from the greater Philly or NYC metropolitan areas. The quiet lake is great for swimming, boating and fishing. It's a motor boating lake but has floating islands so it's a quiet lake (not for jet skis or fast boating). The cottage is located on a double lakefront lot with 160 feet of shoreline. The lot is level to the lake and the road. There's a floating dock with tie off cleats and a ladder. Also included in the rental is the use of 2 row boats with oars and a kayak with paddle, rafts, lawn games, a firepit and a gas grill. Our dining pergola overlooks the lake and has LED rope lighting for nighttime fun. Inside is a well stocked kitchen, dining area that seats up to 8, living room with a gas fireplace and queen size sofa sleeper, screened in porch and 1/2 bath. Upstairs has a full bath and 2 bedrooms and 2 alcoves to sleep 6. There are 2 garages, one being an oversize garage that will easily fit large SUVs or pick up trucks. Our home is pet friendly and offers stainless steel pet bowls, a 75 trolley line, and towels for pet use. Bring the whole family for a fun-filled time at the lake!
Doylestown LodgingsDoylestown: Suite in a house1 BDR • 1 BA • Sleeps 4 • #204917105 to 158 USD/nightIf this Location is not available I have others for you and they do accept Dogs, Cats, Pets. Welcome to Doylestown, PA. Center of Dtown with parking walk to Theater Restaurants Pubs etc... Perfect for a few nights or long stay or few months as well, vacations, traveling or wedding or relocation. The property is a great Victorian Building that people enjoy. The large wrap around porch is a great to read a book a cup of cafe or wine. Relax on the hammock or climb the tree house. Easy check in as we have digicode for the entrance and key prepared in advance. Check out is no problem if we do not have a renter that same day. Plenty of Parking. Internet. Private bathroom. Walking to all. Easy access to 202, 309, 95 perfect destinations. Near Princetown Philadelphia New York.


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An estimated 62% of the 19 million eligible voters went to the polls in Sunday's parliamentary elections – this was down from the 75% seen in the 2005 elections, but was still a very respectable turnout.
Preliminary results should be available this week, but final official results will not be declared until the end of March. The BBC reports that Mr Maliki's State of Law Coalition said it had done well, especially in Baghdad and in the Shia south of Iraq.
We can expect a period of deal-making and horse-trading while the various parties negotiate a coalition agreement – this is just a normal part of the democratic process.
"Today's voting makes it clear that the future of Iraq belongs to the people of Iraq," said the American President, Barack Obama on Sunday.


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About Sinterit
Sinterit is the first manufacturer of desktop selective laser sintering 3D printers, with a mission to accelerate the world's development by giving access to innovative 3D printing SLS technology. It has a focus on ease of use, versatility and availability, so that tomorrow can happen today. The company, founded by former Google employees with experience in the industry since 2014, delivers reliable, high-precision printers to customers around the world. During its three years on the market, Sinterit LISA has printed thousands of 3D products. For more information visit www.sinterit.com or follow @Sinterit on Facebook, Twitter or watch our new film on YouTube.
Latest Products from SinteritSEE ALL PRODUCTS


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Winter Rain
What happens when love gets caught in the rain?
A 2015 IPPY Gold Medal Award winner!
In this second volume in the Love in the Rain series, Del Dryden's heroines find shelter from a powerful thunderstorm in their feelings for each other, while Alexis Hall's heroes find the past between them washed clean by falling rain. Inara Scott's hero and heroine upend their lives with a kiss in the rain, while Serena Bell's characters set their world to rights in a winter storm. Rain helps Amber Lin's lost lovers find each other, light morning rain washes away evidence of a goddess's visit in Suleikha Snyder's story, and rain-slicked city streets provide a backdrop for a burgeoning romance in Tamsen Parker's tale. Rainy days bring solace to Cole McCade's hero, while Stacy Reid's heroine makes a bold journey toward love in a raging storm. Nine romance novelettes, edited by Sarah Frantz.
All proceeds from the volume will be donated to the Rape, Abuse, and Incest National Network (www.rainn.org), the largest anti-sexual violence organization in the United States.


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Share photos, a calendar, and more with family members on iPod touch
With Family Sharing on iPod touch, you can share a family photo album, a family calendar, your location, and more.
Share photos or videos with family members
When you set up Family Sharing, a shared album called Family is automatically created in the Photos app on all family members' devices, which makes it easy to share family photos or videos.
Open the Photos app , then select a photo or video, or select multiple photos or videos.
Tap , then tap Shared Albums.
Add any comments you want, then tap Shared Albums.
Choose an album to add the photo or video to.
Members can unsubscribe from the family album, and the family organizer can delete it or remove subscribers. See Share iPod touch photos with Shared Albums in iCloud.
Add an event to the family calendar
When you set up Family Sharing, a shared calendar called Family is automatically created in the Calendar app on all family members' devices. You can schedule an event on this calendar to share it with family members.
Open the Calendar app , then add an event.
While entering the event details, tap Calendar, then tap Family to add the event to the family calendar.
Members can unsubscribe from the family calendar, and the family organizer can delete it. See Share iCloud calendars on iPod touch.
Share your location with family members
With Family Sharing, you can share your location with members of your family group. When the family organizer sets up Location Sharing in Family Sharing settings, the organizer's location is automatically shared with everyone in the family. Then family members can choose whether or not to share their location.
When you share your location, your family members can see your location in Find My and Messages and, if your device is lost, they can help you locate it with Find My.
Note: To share your location, you must have Location Services turned on in Settings > Privacy.
Go to Settings > [your name] > Family Sharing > Location Sharing, then turn on Share My Location.
Tap Change My Location to This iPod touch.
Tap a family member you want to share your location with, tap Share My Location, then tap .
You can repeat this step for each family member you want to share your location with. Each family member receives a message that you're sharing your location and can choose to share their location with you.
You can also send or share your location while using the Messages app (iOS 8, iPadOS 13, or later) by tapping the profile picture or name at the top of the conversation, tapping , then tapping Send My Current Location or Share My Location.
To stop sharing your location with a family member, go to Settings > [your name] > Share My Location. Tap the family member, then tap Stop Sharing My Location.
To find a family member's location, use the Find My app .
Share a Personal Hotspot
With Family Sharing, you can share an Internet connection through a Personal Hotspot with members of your family group. When a member of your family group sets up a Personal Hotspot, other family members can use it to share an Internet connection without having to enter the password. See Use iPhone as a Wi-Fi hotspot.


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Building A Completely New Factory Has Several Benefits
Companies that sell manufactured items currently have one or two choices for creating products. A single popular choice is contracting with a manufacturing facility in another country to create the items at low costs. Despite the fact that this option is actually a fantastic selection for firms that require to economize, choosing this option demands a organization to hand over a certain amount of control over the production in their goods. Except when they already have an office within the county where the production line is found or perhaps the ability to journey whenever it's appropriate to take care of slight issues, business people have to depend on the plant administration to deal with the everyday obligations. The other choice is to build a manufacturing facility. While buying a used production line might be possible, the refurbishments needed will make it much more expensive than new development. The key worry for the majority of producers will be the initial charges. Thankfully, this price might be mitigated by simply joining up with the community administration or even a privately owned firm to make use of a section of the room inside of the factory. This also slashes the financial risk to the business. To locate additional info about this solution, view this page. Businesses that do not have a lawyer on retainer may well gain from achieving this before they start developing. Getting an lawyer or attorney that concentrates on business legislation accessible to reply to inquiries and solve troubles can be priceless for firms that plan to make a large investment in the neighborhood. One other thing to think about is whether or not the company make use of environmentally friendly components and operations in the manufacturing facility. Doing so may trigger tax breaks or a improvement in sales from eco-conscious customers. An adviser will help a firm arrange a plan that can help them get the most from their selection to build a local manufacturing facility. Even though reading through recommendations on the web can be helpful, for certain advice, it is important to find out more from the source. A properly qualified adviser can easily guide the business through the process and make sure they already have all of the assets they really need in order to find the optimum area and select the optimal construction team for the factory. Preparing is important to success in this type of undertaking.


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Strat Land Exploration Company was incorporated in 1980 by its founder and president Larry B. Darden. The principal area of exploration since inception has been the Texas and Oklahoma Panhandle and regions of southern Kansas. Strat Land began operating its first wells in 1984 and has since grown to over 340 operated wells and approximately 100 non-operated wells. Strat Land currently drills 30-40 wells per year in search for natural gas and oil at depths that range from 3,000' to greater that 12,000'. Strat Land has made numerous new field discoveries and field extensions across the region and is considered one of the most consistent, stable, and successful explorers for new fields in the Panhandle area. Since 1980, Strat Land has developed a diversified portfolio of geologic prospects and producing oil and gas properties, including Brown Dolomite, Tonkawa, and Cleveland fields as well as deeper Morrow and Chester fields. In addition, Strat Land has recently discovered new oil fields in the Hunton Formation utilizing 2-D and 3-D seismic. Strat Land has maintained a large acreage position and is active in most of the Panhandle's unconventional horizontal plays. Over the past 20 years the company has had an average drilling success rate of approximately 80% and in the last 10 years the success rate has been near 90%.
From a single employee, the company has grown to over twenty full-time personnel and most have been with the company for more than 10 years. Given its competent staff, its large inventory of undeveloped locations, and its sound business plan, Strat Land's future is very bright for continued success in providing clean burning energy for our nation.


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This morning Chloe wanted a piece of bread.
She asked if I can take the skin off. :)
Skin, Crust, what's the difference to a three year old?
Tuesday, September 8, 2009
a little something from Chloe
1 comment:
What a freak =)
- September 12, 2009 at 10:13 AM
Subscribe to: Post Comments (Atom)


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I really like the story of Ace Hardware, but you're going to have to wait a moment before I spill the beans. This is a store that has a rich history and a proven track record of providing quality items and outstanding service to its customers. This is a company that has not only stood the test of time, but one that has positively thrived. We're about to head back in time to the early 1900's, but before we do that, we need to outline some goals.
Okay first things first we need to get you an Ace Hardware application, and then we need to find out the winning lottery numbers for the last eighty years and jump around time winning tons of money before we come back to the present. I have a fairly strong grasp on quantum mechanics so I don't think that's going to mess anything up. Okay fine, we'll stick to just exploring the history of the company.
Company History & Overview
I know the time machine malfunctioned and now you have a third arm in the center of your chest, but I promise you we're going to get that fixed. In the meantime, could you type this article for me? Nice, that's much faster. So welcome to 1924, when Richard Hesse, E. Gunnard Lindquist, Frank Burke, and Oscar Fisher founded Ace Hardware in Chicago, Illinois. Okay, back in the machine, I've got a schedule to keep here.
Now we're in 1928, and may I say, that set of twelve eyes you have now is just stunning, I really don't think anyone's going to notice, it's really a minor change, and besides, I told you not to eat pizza from the early 1900's. This was the year that Ace Stores was incorporated with the goal of having a centralized location to supply the founders' and owners' stores. The name of the company comes from the ace fighter pilots of World War I who overcame insurmountable odds to survive.
In the same way, the company's retail network expands to hundreds of dealers by 1949 and started pulling in $10 million in annual sales. After Hesse retired in 1973, the Ace Hardware was sold to its retailers which turned it into the retailers' cooperative that it is today. The headquarters also moved to Oak Brook. The independent owners at this point became dealer-owners and shareholders in the company. Pay attention here, you've got six pairs of ears now so I know you can hear me. This is not a franchise run business, which means that each store looks different. Even so, the company has endeavored to try and establish consistent product brands so people recognize an element of the brand.
Back to the present then, and it looks like everything didn't get fixed. Well, look on the positive side, with all those mutated limbs you're bound to get recognized. Now the people at Ace Hardware can put a name to the, uh, faces. Today, Ace Hardware has 4,500 domestic and international stores and 14 U.S. distribution centers. The annual sales figures are huge, pushing $13 billion a year, making it recognized by Forbes Magazine as one of the top 25 companies in the U.S.
Alright, well now that we've got a solid feel for the company's vision, it's time to see how you can start your career with the company, even if my little time travel experiment exposed you to gamma radiation and turned you into a walking Picasso painting.
Direct Competitors
While they may have an iron grip on what they do, there are other companies out there who are vying for your attention. Check out our page on Home Depot, one of the largest hardware stores there is. Menards is always recruiting high quality talent as well. Don't forget Lowe's, they are in the top three hardware stores in the nation. Check out our in-depth articles on all three and put your name down for each one to maximize your options!
Ace Hardware Application Online
Even though the company structure of Ace Hardware is broken up into many different owners as part of its retailers' cooperative set up, the company website offers a great store locator that can put you in touch with your local store and bring you opportunities to submit an online employment form. Once you found a store near you, select it on the map and choose the "See Details" option.
This will direct you to a specific page for that Ace Hardware location. There are hours of operation, and the names of both the owner and the store's manager. Even more interesting is that you can read the specific story of the owner and how they came to own a location in this company. For example, I was reading the story behind Walter Toole who owns several locations and I found it to be very refreshing how much transparency is present within the company.
His particular story starts all the way back in 1906, but don't worry, I dismantled the time machine to prevent any future human sculpture accidents. Since 1989, the Toole's have been running their own Ace Hardware locations because they believe in the company's motto: "Ace is the helpful place."
There is a link on the company website to a third party website that is owned by the Toole's, and you'll find a similar link on the location you choose. On the Toole's website I was able to find the online employment form quite easily, and there was an option to download the forms as well, which is always nice. Since you're dealing with a separate owner and manager, you'll want to be doubly sure to stop in and introduce yourself as they probably get a lot of random inquiries, and you want yours to stand out from the rest. The most common position that is currently available is the cashier position. You'll need to be at least eighteen years old to start working with the company.
As a cashier, you'll just need to have great customer service, and someone who lets their personality shine in all that they do. You will also need to work quickly and efficiently to ensure that everyone is rung up and that purchases happen smoothly. The starting pay is negotiable based on the location where you're applying, and how much experience you have. Here are some quick qualifications you'll need for this entry-level position:
- Some Experience is required
- High School Diploma or equivalent
- Authorized to work in the United States
- Need Reliable Transportation
- Background Check is Required
Benefits when Working With The Company
There are some attractive benefits you can take advantage of when working with the company. Even if you're just looking for a part-time job to pay the bills, you'll still find a lot to love about the unique nature of each store. Benefits packages are widespread and very competitive. Employees who are eligible can receive the following benefits:
- Full Medical Insurance
- Dental Insurance
- Vision Insurance
- Life Insurance
- Paid Vacation
- Holiday Pay
- Retirement Plans
- Discounts on store products and services
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In general, when an organism is placed under sudden stress, the level of activity of the cells exciting complement of enzyme increases, leading to a spurt in production. Epinephrine synthesis in the adrenal medulla is also subject to the biochemical influence of .the adrenal cortex. Because blood from the cortex passes through the medulla, most of the chromaffin cells are exposed to high levels of cortical steroids, When the steroids are absent, it has been found that the enzyme that catalyzes the conversion of norepinephrine into epinphrine is degraded at an unusually high rate, leading to the decline of its cellular level. Thus, the intimate anatomical relation of the cortex and the medulla extends to the interaction at molecular level as well.
Stress is known to induce the secretion of hormones from the adrenal cortex as well as from the meulla. The cortical hormones apparently ensure that the synthesis of epinephrine is maintained1). Kohler and his collaborators2) found that estradiol and progesterone administration to intact female rats increased adrenal tyrosine hydrosylase activity. Moreover, tyrosine hydroxylase activity is known to be increased significantly in diethylstilbesterol-induced pituitay tumors of the rats than in control pituitaries. These data support the possible existence of local catecholaminergic mechanism(s) that could be modulating prolactin secretion from pituitary tumors and from ectopic pituitaries3).
In hypothalamic and vocal control nuclei of male zebra finches, all hormone-induced changes in noradrenergic neurotrasmission are estrogen-dependent, while modulation of dopaminergic function is much more variable and frequently androgen-dependent4). Steroids are also known to affect catecholamine (CA) synthesis5), degradation6), release7) and re-uptake9).
However, the steroid-induced hyperpolarization in guinea-pig ganglion neurons in vitro was accompanied by a change in the input resistance of the cell, indicating an involvement of some kind(s) of ion channel(s) in the action of glucocorticoid10). It has been also shown that brief hyper-polarization and increased potassium conductance are produced by 17-β-estradiol in rat medial amygdala brain slices11). Moreover, according to the results of Miguel and his co-workers12). estradiol seems to decrease the ability of the adrenal medulla to release CA to the peripheral blood, whereas progesterone most affects tyrosine hydrosylase activity. Being that its effects temporally and partially depend on estrogens.
It has been also found that 17-α-estradiol inhibits DMPP- and high K+-induced CA release from the cat adrenal glands and 45Ca++ uptake into bovine chromaffin cells in culture stiulated by DMPP or high K+13). More recently. Laret and his collaborators14) have suggested that the amygdaloid catecholaminergic systems exert an inhibitory effect on CA content of the adrenals and the ovary, and influence the ovarian estradiol secretion mechanism. This influnce of the amygdala in the regulation of the ovary could be mediated by an efferent pathway from the central nervous system to the ovary.
Thus, there are many controversial reports on CA release from the adrenal medulla. The present study was designed to examine the effect of 17-α-estradiol on CA secretion from the isolated perfused rat adrenal glands and to clarify the mechanism of its action.
1. Experimental Procedure
Male Sprague-Dawley rats, weighing 180 to 250 grams, were anesthetized with ether. The adrenal gland was isolated by the method described previously15). The abdomen was opened by a midline incision and the left adrenal gland and surrounding area were exposed by placing three hook retractors. The stomach, intestine and portion of the liver were not removed, but pushed over to the right side and covered by saline-soaked gauge pads, and urine In the bladder was removed in order to obtain enough working space for tying blood vessels and cannulations.
A cannula, used for perfusion of the adrenal gland(Fig. 1-A), was inserted into the distal end of the renal vein after all branches of the adrenal vein(if any), vena cava and aorta, were ligated. Heparin (400 IU/ml) was injected into vena cava to prevent blood coagulation before ligating vessels and cannulations. A small slit was made into the adrenal cortex just opposite the entrance of the adrenal vein. Perfusion of the gland was started, making sure that no leakage was present, and the perfusion fluid escaped only from the slit made in the adrenal cortex. Then the adrenal gland, along with ligated blood vessels and the cannula, was carefully removed from the animal and placed on a platform of a leucite chamber. The chamber was continuously circulated with water heated at 37±1 °C (Fig. 1-B)
2. Perfusion of Adrenal Gland
The adrenal glands were perfused by means of a ISCO pump (WIZ Co.) at a rate of 0.3 ml/min. The perfusion was carried out with Krebs-bicarbonate solution of following composition (mM):NaCl, 118.4:KCl, 4.7:CaCl2, 2.5:MgCl2, 1.18:NaHCO3, 25:KH2PO4, 1.2:glucose, 11.7. The solution was constantly bubbled with 95% O2±5% CO2 and the final pH of the solution was maintained at 7.4±0.05. The solution contained disodium EDTA (10 ug/ml) and ascorbic acid (100 ug/ml) to prevent oxidation of catecholamine.
3. Drug Administration
The perfusions of DMPP (100 uM) and McN-A-343 (100 uM) for 2 minutes and/or a single injection of ACh (5.32 mM) and KCl (56 mM) in a volume of 0.05ml were made into the perfusion stream via a three way stopcock, and Bay-K-8644 (10-5M) was also perfused for 4 min.
In the preliminary experiments it was found that, upon administration of the above drugs, secretory responses to ACh, KCl, McN-A-343 and Bay-K-8644 returned to pre-injection level in about 4 min, but the responses to DMPP in 8 min.
4. Collection of Perfusate
As a rule, prior to each stimulation with cholinergic agonists or excess K+, perfusate was collected for 4 min to determine the spontaneous secretion of CA (background sample). Immediately after the collection of the background sample, collection of the perfusates was continued in another tube as soon as the perfusion medium containing the stimulatory agent reached the adrenal gland. Stimulated samples were collected for 4 to 8 min. The amounts secreted in the background sample have been subtracted from those secreted from the stimulated sample to obtain the net secretion value of CA, which is shown in all of the figures.
To study the effects of 17-α-estradiol and its antagonist on the spontaneous and evoked secretion, the adrenal gland was perfused with Krebs solution containing 17-α-estradiol for 20 min. the perfusate was collected for a certain background sample, and then the medium was changed to the one containing the stimulating agent and the perfusates were collected for the same period as that for the background sample. Generally, the adrenal gland's perfusate was collected in chilled tubes.
5. Measurement of Catecholamines
CA content of perfusate was measured directly by the flurometric method of Anton and Sayre16) without the intermediate purification alumina for the reasons described earlier15) using fluorospectrophotometer (Schimadzu Co. Japan).
A volume of 0.2 ml of the perfusate was used for the reaction. The CA content in the perfusate of stimulated glands by secretogogues used in the present work was high enough to obtain readings several fold greater than the reading of control samples (unstimulated). The sample blanks were also lowest for perfusates of stimulated and non-stimulated samples. The content of CA in the perfusate was expressed in terms of norepinephrine (base) equivalents.
6. Statistical Analysis
All data are presented as means with their standard errors, and the significance of differences were analyzed by Student's paired t-test using the computer system as previously described17).
7. Drugs and Their Sources
The following drugs were used: 17-α-estradiol, 17-β-estradiol, acetylcholine chloride, 1.1-dimethyl-4-phenyl piperazinium iodide(DMPP), norepinephrine bitartrate. methyl-1, 4-dihydro-2, 6-dimethyl-3-nitro-4-(2-trifluoro-methylphenyl)-pyridine-5-carboxylate (BAY-K-8644), metoclopramide hydrochloride (Sigma Chemical Co., U.S.A.). tamoxifen citrate, (3-(m-cholro-phenyl-carbamoyl-oxy)-2butynyl trimethyl ammonium chloride [McN -A-343] (RBI, U.S.A). Drugs were dissolved in distilled water (stock) and added to the normal Krebs solution as required, except Bay-K-8644, 17-α-estradiol, 17-β-estradiol and tamoxifen, which were dissolved in 99.5% ethanol and diluted appropriately (final concentration of alcohol was less than 0.1%). Concentrations of all drugs used are expressed in terms of molar base.
1. Effect of 1 uM 17-α-estradiol on CA Secretion Evoked by ACh, Excess K+, DMPP and McN-A-343 from the Perfused Rat Adrenal Glands
After the initial perfusion with oxygenated Krebs-bicarbonate solution for 1 hr, basal CA release from the isolated perfused rat adrenal glands amounted to 24.3± 2.8 ng/2 min (n = 8). Being a typical and widely used female sexual hormone, it was decided initially to examine the effects of 17-α-estradiol on cholinergic receptor stimulatin, as well as membrane depolarization-mediated CA secretion from perfused rat adrenal glands. Secretogogues were given at 20 to 30 min-intervals. 17-α-estradiol was present 20 min before each stimulation. In the present study, it was found that 17-α-estradiol itself did not produce any effect on basal CA output (data not shown).
When ACh (5.32 mM), in a volume of 0.05 ml. was injected into the perfusion stream, the amounts of CA secreted was 595.0±53.5 ng for 4 min. However, after the pre-perfusion with 1 uM 17-α-estradiol for 20 min, Ach-stimulated CA sectrtion was significantly decreased to 421.3± 32.5 ng (p<0.01) for 4 min from 12 adrenal glands as shown in Fig. 2. On the other hand, it has been found that depolarizing agent like KCI sharply stimulates CA sectretion. In the present work, excess K+ (56 mM)-stimulated CA secretion after the pre-treatment with 1 uM 17-α-estradiol for 20 min was not affected. In the presence of 1 uM 17-α-estradiol, it amounted to 372.9±21.8 ng (ns) for 4 min as compared with its corresponding control secretion of 431.8± 31.4 ng for 4 min from 14 glands (Fig. 2).
When perfused through the rat adrenal gland, DMPP (100 uM for 2 min), which is a selective nicotinic receptor agonist in autonomic sympathetic ganglia, evoked a sharp and rapid increase in CA secretion. As shown in Fig. 3, DMPP-stimulated CA secretion before pre-loading with 1 uM 17-α-estradiol was 781.9±77.2 ng (0–4 min) and 147.9±32.8 ng (4–8 min), while after pre-treatment with 1 uM 17-α-estradiol for 20 min they were greatly reduced to 425.6±45.4 ng (0–4 min, p<0.01) and 30.0±8.7 ng (4–8 min, p<0.01), respectively from 8 rat adrenal glands. As illustrated in Fig. 3. McN-A-343 (100 uM), which is a selective muscarinic Mi-agonist18), perfused into and adrenal gland for 2 min caused an increased CA secretion to 113.3±24.5 ng for 4 min from 9 experiments. However, McN-A-343-stimulated CA secretion in the presence of 1 uM 17-α-estradiol was markedly inhibited to 28.3±4.6 ng (p<0.01) for 4 min, which is 25% of the corresponding control secretion.
2. Effect of 10 uM 17-α-estradiol on CA Secretion Evoked by ACh, Excess K+, DMPP, McN-A-343 and Bay-K-8644 from the Perfused Rat Adrenal Glands
In order to test the dose-dependent effects of 17-α-estradiol on cholinergic receptor-stimulated CA secretion, as well as membrane depolarization-mediated secretion, more increased concentration of 17-α-estradiol to 10 uM was pre-loaded into the adrenal medulla. Fig. 4 shows that 10 uM 17-α-estradiol-pre-treatment greatly exerts inhibition of CA secretion evoked by ACh. but not by excess KCI. In the present study, ACh (5.32 mM)-stimulated CA secretion prior to pre-loading with 10 uM 17-α-estradiol was 513.0 ± 56.6 ng for 4 min from 5 rats. However, under 10 uM 17-α-estradiol effect, which was perfused 20 min before stimulation was induced, it was markedly inhibited to 351.0 ± 26.2 ng (p<0.01) for 4 min, which was 68% of its corresponding control secretion. Excess K+ (56 mM)-stimulated CA secretion in the presence of 10 uM 17-α-estradiol amounted to 269.3±25.3 ng/4 min from 7 glands, as compared to the corresponding control secretion of 308.6±12.2 ng/ 4 min. There was no significant difference between the both groups of before and after pre-treatment with 10 uM 17-α-estradiol, as shown in Fig. 4.
Nicotinic receptor agonist. DMPP (100 uM) perfused into the adrenal gland evoked great CA sectrtion of 592.5 ± 57.5 ng (0–4 min) and 160.0±44.3 ng (4–8 min). while following perfusion with 10 uM 17-α-estradiol for 20 min they were markedly reduced to 312.5 ± 27.2 ng(0–4 min, p<0.01) and 27.5 ± 7.2 ng(4–8 min, p<0.05) from 5 adrenal glands as compared with their control responses, respectively as shown in Fig. 5.
In 5 rat adrenal glands, McN-A-343 (100 uM)-stimulated CA sectretion was 114.0 ± 12.7 ng/4 min before administration of 10 uM 17-α-estradiol but in the presence of 10 uM 17-α-estradiol, McN-A-343-evoked CA secretion was significantly decreased to 57.0 ± 27.0 ng (p<0.01) of its control secretion as shown in Fig. 5.
Since Bay-K-8644 is known to be as a calcium channel activator and to cause positive inotropy and vasconstriction in isolated tissues and intact animals19,20) and to enhance basal Ca++ uptake21) and CA release22), it was of interest to determine the effects of 17-α-estradiol on Bay-K-8644-stimulated CA secretion from the isolated perfused rat adrenal glands. Fig. 6 illustrates the inhibitory effect of 10 uM 17-α-estradiol on Bay-K-8644-evoked CA secretion. Bay-K-8644 (10 uM), given into the perfusion stream for 4 min, increased CA secretion to 224.5±18.8 ng from 17 rat adrenal glands. However, under the effect of 10 uM 17-α-estradiol which was pre-loaded 20 min before Bay-K-8644 was introduced. Bay-K-8644-stimulated CA secretion was strikingly depressed to 126.1±17.3 ng (p<0.01) for 4 min as compared to the corresponding control releases. Thus, the release was reduced to 56% of the control secretion.
3. Effect of 100 uM 17-α-estradiol on CA Secretion Evoked by ACh, Excess K+, DMPP McN-A-343 from the Perfused Rat Adrenal Glands
It was tried to examine the effects of 17-α-estradiol, as a maximal concentration in the present experiment, on cholinergic receptor-stimulated as well as membrane depolarization-mediated CA secretion from the isolated perfused rat adrenal glands. Prior to pre-loading with 100 uM 17-α-estradiol, CA secretion evoked by a single injection of ACh (5.32 mM) and excess K+ (56 mM) in a volume of 0.05 ml into an adrenal gland was 521.7±87.4 ng and 331.9±22.9 ng for 4 min. respectively as shown as in Fig. 7. However, following the pre-loading with 100 uM 17-α-estradiol for 20 min, ACh-induced CA release was greatly blocked to 345.0± 50.9 ng (p<0.01, n = 9) for 4 min while excess K+-induced release was 308.3±30.4 ng (ns, n = 8), which was not modified as compared to its corresponding control secretion (Fig. 7).
Fig. 8 shows the blockade of 100 uM 17-α-estradiol to CA secretory effect evoked by DMPP and McN-A-343 from the rat adrenal glands. In the present work, in the absence of 100 uM 17-α-estradiol, DMPP (100 uM)-and McN-A-343 (100 uM)-evoked CA secretion amounted to 747.5±97.6 ng(0–4 min) and 198.0±52.3 ng (4–8 min), and 169.3±32.0 ng (0–4 min), respectively, while in the presence of 100 uM 17-α-estradiol. which was pre-loaded 20 min before stimulation, they were prominently depressed to 362.5±44.9 ng (0–4 min, p<0.01, n = 6) and 12.0±4.8 ng (4–8 min, p<0.01, n = 6) and 38.6±6.4 ng (0–4 min, p<0.01, n = 7), respectively.
4. Effect of 17-β-estradiol on CA Secretion Evoked by ACh, Excess K+, DMPP and McN-A-343 from the Isolated Rat Adrenal Glands
In the previous experimental results, as shown in Fig. 3–8, it was found that 17-α-estradiol showed a dose-dependent inhibition in CA secretory responses. Moreover, It has been known that administration of 17-β-estradiol to 3-week ovariectomized fish (Clarias batrachus) results in both seasonal and differential effects on the CA levels. After 3-weeks of ovariectomy, CA levels were elevated significantly in the preparatory, pre-spawning and spawning phases, and were unaltered in the post-spawning season23). Therefore, it is likely of interest to examine the effect of 17-β-estradiol on CA secretion evoked by various secretagogues.
CA release evoked by ACh (5.32 mM) and excess K+ (56mM) after pre-loading with 10 uM 17-β-estradiol for 20 min amounted to 390.0±28.2 ng (p<0.01, n=13) and 372.9±32.7 ng (ng. n = 14) for 4 min, respectively, as compared to each corresponding control secretion of 662.3±82.0 ng and 428.2±32.3 ng for 4 min as shown in Fig. 9.
DMPP (100 uM)-and McN-A-343 (100 uM)-stimulated CA releases in the absence of 17-β-estradiol were 920.6±96.5 ng (0–4 min) and 425.6±63.6 ng (4–8 min), and 219.4±17.1 ng (0–4 min), respectively. However, after pre-loading with 10 um 17-β-estradiol for 20 min, they were significantly reduced to 470.6±35.6 ng (0–4 min, p<0.01, n = 8) and 176.3±8.9 ng (4–8 min, p<0.01, n = 8), and 56.3±16.0 (0–4 min, p<0.01, n = 8), respectively, as compared to their corresponding control secretion. Fig. 10 illustrates that 17-β-estradiol markedly inhibits CA release evoked by DMPP and McN-A-343.
5. The Effects of 17-α-estradiol Plus Tamoxifen on CA Release Evoked by ACh, Excess K+, DMPP and McN-A-343
Since it has been found that tamoxifen is a competitive inhibitor of estrogen binding at the estrogen receptor24–26), it was tried to determine the effect of 17-α-estradiol in the presence of tamoxifen on CA secretion evoked by various secrettagogues from the isolated rat adrenal glands.
When given into an adrenal vein in a volume of 0.05ml. ACh (5.32 mM)-and excess K+(56mM)-induced CA releases, in the presence of 10uM 17-α-estradiol along with 2 uM tamoxifen for 20 min, were considerably recovered to 86.6±6.3% (p<0.05, n=8) and 94.3±9.3% (ns, n=7) of their control secretion (100%), respectively, as compared to their secretory responses of 67.4±2.3 and 86.7±1.9% of their controls in the presence of 17-α-estradiol only(Fig. 10).
On the other hand. 17-α-estradiol plus tamoxifen treatment did fail to alter the basal CA secretory response (data not shown). As depicted in Fig. 12. DMPP (100 uM)- and McN-A-343 (100 uM)-induced CA secretions under existence of 17-α-estradiol plus tamoxifen were also significantly recovered to 67.8±3.1%(0–4 min, p<0.01, n=8) and 59.7±5.4%(4–8 min, p<0.01, n=8) and 70.0±4.8% (0.4 min, p<0.01, n=6) of their corresponding control responses, respectively, as compared to the secretory responses of 47.5±2.5% (0–4 min) and 21.7±5.1% (4–8 min), and 33.4±3.5%(0–4 min) of the control in the presence of 10 uM 17-α-estradiol only (Fig. 11).
6. The Effect of 17-α-estradiol Plus Metoclopramide on CA Release Evoked by ACh, Excess K+, DMPP and McN-A-343
It was tried to examine the relationship between dopaminergic and estrogenergic receptors in CA release. It has been reported that dopamine-induced inhibition of release of [3H] norepinephrine from the isolated perfused rabbit adrenal glands could be reversed completely by the dopamine D2 selective antagonist metoclopramide27,28).
ACh (5.32mM)- and excess K+ (56 mM)-induced CA secretory responses after pre-loading with Krebs solution containing 10 uM 17-α-estradiol along with 33 uM metroclopramide for 20 min amounted to 52.8±3.2% and 82.3±5.8% of each corresponding control (100%), respectively. They were not significant as compared to the secretory responses of 60.9±4.6% and 89.1±6.7% of the controls in the presence of 17-α-estradiol only as shown in Fig. 13.
Furthermore, DMPP (100 uM)- and McN-A-343(100 uM)-stimulated CA secretory responses in the presence of 10 uM 17-α-estradiol plus 33 uM metoclopramide were 62.4±3.6% (0–4 min, ns, n=8) and 33.2±2.1% (4–8 min, ns, n=8), and 55.9±4.2% (0–4 min. ns, n=6), respectively, as compared to their secretory responses of 57.3±3.5% (0–4 min) and 28.7±5.1% (4–8 min), and 50.2±6.3% (0–4 min) of the controls as depicted in Fig. 14.
In the present study, the experimental results suggest strongly that 17-α-estradiol causes the inhibitory effect of CA secretion evoked by cholinergic (nicotinic or muscarinic) receptor stimulation and Bay-K-8644, but not that by membrane-depolarization, indicating that this effect may be mediated by inhibiting the influx of extracellular calcium into the rat adrenomedullary chromaffin cells through the activation of inhibitory estrogen receptors, and it also play a modulatory role in regulating CA secretion.
In support of this idea, Lopez and his collabolators13) have found that the steroid hormone 17-α-estradiol blocks CA secretion from adrenal chromaffin cells in response to some secretagogues. Although this effect is especially clear upon nicotinic stimulation and, to a lesser extent with high K+ stimulation, it is dubious in the case of muscarinic-mediated secretion. However, it seems that there is some difference between results of previous reports and the present investigation. In the present experimental results, 17-α-estradiol markedly inhibited CA secretory responses of DMPP and McN-A-343, but did not affect that of excess K+. The resson for this discrepancy is not explained, but the discrepancy may be due to the species differences in the adrenal medulla.
Moreover, Leret and his co-workers14) have also shown that, in the adrenal medulla, the CA levels measured in animals lesioned with 6-hydroxydopamine were significantly higher than those of the controls. Thus, it could be suggested that the CA of the amygdala plays an inhibitory role in animals with 6-hydroxydopamine lesions in the CNS region. The activity of the adrenal medulla can also be influenced by steroid hormones produced in the ovary29). These hormones not only modify the production of corticosteroids but also the activity of some medullary enzymes. Namely, it has been demonstrated that low levels of ovarian steroids reduce MAO and phenylethanolamine-N-methyltransferase (COMT) activities, with no changes of COMT activity14). This mechanism could be involved in the increase of CA in the adrenal medulla obtained after lesions in the amygdala. A similar effect has also been described in several brain areas30–32). Thus, the adrenal medulla activity of COMT, the enzyme involved in the inactivation of CA by o-methylation, was significantly increased after the treatment with either estradiol or progesterone29).
Miguel and his co-workers12) have found that the CA release, measured after in vitro incubations of adrenomedullary tissue, is significantly reduced during the estrosus phase. Most likely, pre-ovulatory increase of estradiol, occurring during the early progestrous33), would be responsivle for this decreased CA release, since the pharmacological administration of estradiol to overiectomized rats produced a similar decrease in the CA release 24 hr after the steroid injection. They have also suggested that the effects of sex steroid on adrenal medulla would be produced by a direct action on chromaffin cells through a classic genomic mechanism34). In this respect, the existence of cytoplasmic steroid receptors has been observed in the whole adrenal35).
However, these results are not concordant with the present experimental data. Because, first, the inhibitory effect by 17-α-estradiol of CA release is established within 20 min and, second, its effect is readily reversible upon washing out the hormone. Rather, its effect might be ascribed to the direct action to the membrane rapid actions observed in different neuronal systems. The rapid effect that, in the present investigation, 17-α-estradiol inhibited CA secretion evoked by DMPP and McN-A-343 is not explained in the frame of the classical genomic mechanism of steroid hormone actions through activation of high-affinity cytosolic receptors and their further translocation to the cell nucleus to induce new protein synthesis. These effects are generally known to take hours or even days to appear36).
Rather, the catecholamine blocking effects are better explained in the newly emerging concept of cell membrane effects of steroids in neurons. In support of these ideas, there are several recent example reports of these nongenomic, rapid effects of steroids. By applying steroids directly to specific neurons, immediate changes in their firing frequency are observed10,11,37,38). The activity of hormone-sensitive striated muscles can be enhanced within minutes of steroid treatment39). As these rapid steroid effects are not prevented by protein synthesis inhibitors11,39), it seems that they result from a direct action of steroids on the plasma membrane. In the light of these facts, it is suggested that the target for 17-α-estradiol is located on the plasma membrane of the rat adrenomedullary chromaffin cells. If this hormone were acting at some intracellular site on the secretory machinery, the responses to all secretagogues would be blocked the same extent.
Furthermore, in the present study, 17-α-estradiol also inhibited the secretory effect of CA evoked by Bay-K-8644, which is known to be a Ca++uptake21) and CA release22). In terms of this view, the present finding that 17-α-estradiol depressed CA secretory effects by Bay-K-8644, as well as cholinergic receptor-stimulation without effect on membrane-depolarization, strongly suggests that the inhibitory effect of 17-α-estradiol is mediated through the blockade of Ca++ entry into the chromaffin cells.
In support of these results, there is now sizeable literature demonstrating a key role of Ca++ influx through voltage-sensitive Ca++ channels as a physiological pathway for activation of adrenal CA40–45). Moreover, it is found that the activation of nicotinic receptors stimulates CA secretion by increasing Ca++ entry through receptor-linked and/or voltage-dependent Ca++ channels in both perfused rat adrenal glands46) and isolated bovine adrenal chromaffin cells47–49), and that the muscarinic receptor activation causes an increase in adrenal CA secretion independent of extracellular Ca++ in various species50–52) and in cytosolic free Ca++ in bovine isolated adrenal chromaffin cells without associated CA secretion45,53–55).
However, recently, Lim and Hwang56) have found that both DMPP and McN-A-343 greatly cause CA secretion from the isolated perfused rat adrenal medulla by a calcium-dependent exocytotic mechanism. Considering in connection with these findings, the present results that 17-α-estradiol inhibited CA releasing responses induced by DMPP and McN-A-343 as well as that by Bay-K-8644, but did not that by excess K+, indicate strongly that this inhibitory activity may be mediated by inhibiting Ca++ influx into chromaffin cells through receptor-linked and/or voltage-sensitive Ca++ channels. However, the fact that 17-α-estradiol did not affect CA secretion evoked by high K+ could not be clearly explained, because DMPP and high K+ are known to increase Ca++ uptake into chromaffin cell through the recruitment of voltage-sensitive Ca++ channels28,57). In addition, Lopez and his co-workers13) have also observed that 17-α-estradiol depresses the secretory responses of CA evoked by both DMPP and high K+ from the perfused bovine and cat adrenal medulla.
In terms of these reports, the present result that 17-α-estradiol fails to inhibit CA release induced by excess K+ from the rat adrenal glands might explain its high potency in blocking CA secretion evoked by DMPP or McN-A-343 than by excess K+, indicating that there is species difference.
On the other hand, in this study, the fact that the inhibitory effect of 17-α-estradiol to the secretory responses evoked by DMPP and McN-A-343 as well as by ACh was recovered to the considerable extent of the control in the presence of tamoxifen indicates strongly that this hormone causes depression in CA release evoked by cholinergic (nicotinic and/or muscarinic) receptor stimulation through the activation of inhibitory estrogen receptors on chromaffin cell membrane. Tamoxifen is a competitive inhibitor of estrogen binding at the estrogen receptor24–25) and blocks estrogen action in breast cancer cells which contain receptors. Recently, Wiseman58) has described that tamoxifen protects membranes and lipoprotein particles against oxidative damage, and that this antioxidant action is likely to contribute to the observed cardio-protective action of tamoxifen and supports the use of this compound in treating and even preventing breast cancer. Membrane-mediated mechanisms of tamoxifen action, through a putative modulation of membrane fluidity are likely to play an important role in it anti-cancer action and its ability to reverse multi-drug resistance and could also lead to clinical uses as anti-candida and anti-viral agents.
Also, in the present investigation, 17-β-estradiol, an isomer of estradiol, inhibited CA secretion evoked by cholinergic stimulation. In support of this fact, after 3 weeks of ovariectomy in female Clarias batrachus, CA levels were elevated significantly in the preparatory, pre-spawinig and spawning phases and were ulaltered in the post-spawning season23).
Administration of 17-β-estradiol to this fish resulted in both seasonal and differential effects on the CA levels. Moreover, it has been reported that 17-β-estradiol also produces brief hyperpolarization and increased potassium conductance in rat medial amygdala brain slices11).
Besides, the finding that 17-α-estradiol-induced inhibitory effects were unchanged by co-administration with metoclopramide, which is known to block dopaminergic receptors, leading to hypertensive crisis59) and CA release by calcium-dependent exocytotic mechanism60), suggests that the inhibitory effects are not associated with dopaminergic receptors in the rat adrenal glands.
In conclusion, 17-α-estradiol causes the inhibition of CA release evoked by cholinergic (nicotinic and/or muscarinic) stimulation as well as that by Bay-K-8644, but not that by membrane-depolarization from the isolated perfused rat adrenl glands, indicating strongly that this inhibitory effect may be mediated by inhibiting calcium influx into the chromaffin cells through the activation to the inhibitory estrogen receptors and it also plays a modulatory role in regulating CA secretion.


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The beauty of building in North Sydney includes opportunities advantageous to:
Located on the northern side of the Harbour Bridge, North Sydney is often described as the commercial district with a contrasting homely touch. This attractive location promotes a healthy lifestyle for locals with coastal treks, beaches and reserves aplenty. North Sydney is also one of the most accessible suburbs for commuters, with great accessibility to public transport through not only a network of trains and buses, but also, ferries. While the area can get busy during the week, weekends are quite the opposite – peaceful and serene. If you want to build your home in a suburb that promotes a well-balanced lifestyle, the suburb should be on your radar, and as home builders North Sydney, we can journey along.
The North Sydney region is surrounded by suburbs of the likes of Cammeray, Cremorne, Cremorne Point, Crows Nest, Kirribilli, Kurraba Point, Lavender Bay, McMahons Point, Milsons Point, Neutral Bay, North Sydney, St Leonards, Waverton and Wollstonecraft. Home builders in North Sydney are seeing a trend in construction within the area, as more Australians love the convenience in location and balance between skyscrapers, high-rise apartments, beautiful Victorian style houses, parks and reserves, capitalising on their Sydney Harbour views. There is also the surrounding of much loved green spaces parks, golf courses and sports fields.
North Sydney has something for everyone, depending on preferences, family build up, leisure and social activities and more. From community centres to educational institutes, North Sydney boasts diversity and involvement. As well as this, it's close proximity to Sydney's domestic and international airports, provide added value to the ease and convenience of living and building in North Sydney.
As leading home builders in North Sydney, our aim is to bring our clients' vision to fruition. With building dream homes, options are endless and modern design allows for innovation, creativity and luxury. To find out more about how we can help, contact us.


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KINGSTON, R.I. – The Jim Fleming Coaches Show returns to the Mews Tavern in Wakefield Thursday night at 6 p.m.
Senior captain and linebacker Justin Hogan will appear as a guest. Hogan was named the CAA Football Co-Defensive Player of the Week Monday after his performance in Rhody's 21-19 win at No. 15/16 Delaware in the season opener. Hogan had six tackles, one fumble recovery and one forced fumble, playing a key role in two turnovers that helped the Rams clinch the win. Also appearing will be linebackers coach Troy Gilmer.
Host Steve McDonald will open the show live with Jim Fleming on News Radio 920 AM or via the iHeart Radio app, and segments with Hogan and Gilmer will follow. In addition to the hour-long show, News Radio 920 AM personnel will be on hand with giveaways for fans.
McDonald and Fleming will discuss last week's win over Delaware, as well as this week's home opener against Albany.
For ticket information for Saturday's game, click here.


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We are offering the Famous Optifast Program which has been used successfully in North America for 25 years. It has been studied and widely published to have extremely high success rates for patient's to lose weight fast and keep it off. It is a medically supervised weight program that helps patients achieve their weight loss goals through a nutritionally complete meal replacement product along with lifestyle change through interaction with our healthcare experts.
Medically Supervised Expert Team – Our team has 25 years in successful weight loss surgeries and non-surgical weight loss programs. We take an innovative but evidence-based approach to our weight loss solutions that provide quick but safe weight loss with uncompromising quality.
Customized support options – Weight loss is a complex issue which is why we have an entire team to look after you. Doctors to help monitor your success, a Dietician to help with personalized food plans, a Personal Trainer to help you create healthy exercise habits, and a lifestyle coach that will focus on helping you develop new coping skills such as stress management.
Wide Range of Solutions – We offer a wide range of solutions which means we are not trying to make something fit that does not. We go through an extensive assessment to get to the root of your weight issues and recommend the weight loss solution that is the right one for you.


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Magazine article Newsweek
Books: Conjuring Up Dark Clouds
Article excerpt
Byline: Malcolm Jones
Robert Oppenheimer had a changeling's face. Seen straight on, he was beguilingly handsome. Seen from the side, he was almost goofy looking. He was slue-footed and a klutz around machines. The contradictions were not superficial: a brilliant physicist who dazzled colleagues with his intellectual improvisations, he often alienated the very people he needed to impress. And while he was notoriously absent-minded, he revealed a genius for administration when he oversaw the development of the atomic bomb in little more than two years. A great American success story, he was also a tragic figure, doomed by many of the qualities that propelled him to fame.
The eldest son in a wealthy Jewish family in New York City, Oppenheimer grew up coddled--his mother wouldn't let him play with other children--and pampered: he didn't go to the barber, the barber went to him. When World War II broke out, this intellectual prodigy was teaching physics at Berkeley and Caltech--and writing checks to left-wing causes. The FBI could never prove that Oppenheimer was a communist; the 10,000 documents in his FBI file show that it wasn't for want of trying.
In Kai Bird and Martin J. Sherwin's definitive biography, "American Prometheus," Oppenheimer is the driving force behind the atom bomb. Appointed director of the project when he was only 42, he marshaled a team of the world's best physicists to build a bomb in record time. …


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Thanksgiving and some tips
I know that I've been a slacker when it comes to posting lately. Things are finally getting back to normal around here and to be honest, I'm just enjoying the calmer feeling.
With Thanksgiving two days away, I'm loving focusing all my time and attention on the big day. Next week, I'll return to blogging on a more regular basis.
In the meantime, I want to remind you about the Complete Recipe Index, over there on the top left. Click on it, scroll to "Holidays" and click again. Then, scroll down to "Thanksgiving." It is there that you will find over 45 recipes for not only the feast but also recipes using the leftovers after Turkey Day.
Lastly, I want to share with you a few video segments I filmed with my friend and 12News anchor, Tram Mai. They are part of a "how to" series the station has run. Some are in my cooking and entertaining wheelhouse, a couple of the others, um … not so much, but I gave it a good college try. What I think will prove to be my favorite segment, "Setting a Proper Table" will air on Thanksgiving morning, I'll post a link, after it airs.
1 comment
- 1 Sheila { 11.23.16 at 9:35 AM }
You deserve it!!!Happy Turkey Day! xo
Leave a Comment


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Niche Game: Grand Theft Auto
The original Grand Theft Auto, the game that started the memorable series, was released by DMA Design, now known as Rockstar North. This is just one in the long list of ingenius games this company is capable of, with such varied gameplay that you never get bored. This game is similar in some ways to its descendents, but has many unique traits of its own.


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SumUp Expenses is a Windows Phone 7 application where the users can track and manage their expenses. This application has
the ability for the users to use their mobile phone to track what they have spent on a daily basis. The user can also
attach receipts for expenses and export them to their computer. The application was built using Visual Studio 2010 with
the Windows Phone 7 SDK and Silverlight 4.0. All data is stored in XML files.
Silverlight 4.0
Windows Phone 7 SDK
Web Services
Add, edit, and delete expenses.
Capture receipts and associate it to an expense.
Allow users to track income.
Optional securtity password which must be entered before data is available.
Create custom categories and sub-categories.
Expenses summary report with date filters and option whether to include captured receipt or not. (Filters allows users to quickly select a day, week, month, year, etc.)
Export expenses summary to computer.
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Here is another valuable Management Tip of the Day from Harvard Business Review. To sign up for a free subscription to any/all HBR newsletters, please click here.
* * *
Resisting distractions seems like an intuitive way to be more productive, yet research shows that excessive focus exhausts your brain. To tap into your "default mode network" — an unfocused state in which your brain activates old memories, enhances self-awareness, and imagines creative solutions — use positive constructive daydreaming.
o Begin a low-key activity, like knitting or gardening, and allow your mind to wander.
o But don't simply slip into a daydream or rehash old worries. Instead, imagine something playful, like running through the woods.
o Hold the wishful image in your mind while continuing the low-key activity. In this unfocused state, your mind will recharge, connect ideas, and even find long-lost memories.
The associations your mind makes during positive constructive daydreaming should enhance your sense of self, making you a more confident leader.
Adapted from "Your Brain Can Only Take So Much Focus," by Srini Pillay
To check out that HBR article and join the discussion, please click here.
Here's a direct link to dozens of other Management Tips.


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LUNATIC FEST. 2018 June 23, 2018 Live report by Meiko Kikuta ACE OF SPADES ACE OF SPADES definitely brought a new crowd to this year's LUNATIC FEST. The collaboration between EXILE (feat. vocalist TAKAHIRO) and GLAY happened on TV in 2005, so the band's appearance was a welcome surprise for both EXILE fans and GLAY …
Tag: Glim Spanky
Feb 05 2018
Best J-Rock on Spotify: Glim Spanky – Orokamonotachi
Today's best J-Rock track on Spotify: Glim Spanky – Orokamonotachi


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ViacomCBS WW
Type: TV
Country: Pan-European
Address: 17-29 Hawley Crescent London NW1 8TT
Website: http://www.viacom.com/brands/pages/vimn.aspx
Status of the company: Independent
Type of company: Private
Number of employees: 0
Contact details
CEO of the sales house/Head of Sales dpt
Name: Bob Bakish
Title: CEO
Contact person
Name: Phil Jenner
Email: [email protected]
Viacom International Media Networks is comprised of many of the world's most popular multimedia entertainment brands, including MTV, Nickelodeon, Comedy Central, BET, Paramount Channel, VH1, VIVA, COLORS and Tr3s: MTV, Musicá y Mas. Viacom brands are seen globally in approximately 700 million households, in approximately 170 territories and 37 languages, via more than 200 locally programmed and operated TV channels and more than 550 digital and mobile TV properties. Keep up with VIMN news by visiting the VIMN PR Twitter feed at www.twitter.com/VIMN_PR and www.blog.viacom.com.


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Office Chairs Ergonomic
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Ravi becomes the target of Bittu, a criminal, after he helps cops catch the latter committing robbery at a bank. And so begins a game of smarts between the two,…
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First Impressions are Lasting Impressions.
The exterior of your home often determines how buyers will view the interior, so:
Accentuate the Positive.
"How we live in a home and how we sell a home are often two different things." Try to see your home with a fresh perspective and arrange each room to bring out its best attributes, including:
Try to see your home with a fresh perspective and arrange each room to bring out its best attributes, including:
Put Your Home in the best possible light.
Strategically lighting your home, even during daytime showings, can create a cozy mood and highlight positive attributes of each room, so:
In General
Try to look at your house "through the buyer's eyes" as though you've never seen it or been there before. Any time or money spent on these items will bring you back more money in return, and hopefully a faster sale.
Occasionally you will receive a call to schedule a showing to take place within the next few minutes. The following is a checklist for this type of panic:
Be one of the first to know when new listings matching your criteria hit the market.Learn more
Research local schools, including rankings, state report cards and school websites.Learn more
Search Austin and surrounding communities with our interactive map.Learn more


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The seventh year of the LinuxDays conference will be held on October 6 and 7 at the Faculty of Information Technology, CTU. The conference program traditionally offers expert lectures, practical workshops, and interesting project boots. Several foreign experts have been invited to this event. FIT lecturers Lukáš Bařinka, Jan Buriánek, and Ondřej Guth will also speak. Participation is free of charge, but you need to register.
The conference traditionally focuses on open-source technologies, so there can not lack Linux technologies, administration of servers, containers, and other topical issues. This year, the organizers ensure another auditorium, so there will be five auditoriums at all. Everything will be recorded and streamed in high-quality thanks to the Silicon Hill Audio-Visual Center.
As usual, the main content of the conference will be expert lectures. There are about seventy lectures prepared. This year, there are more technical workshops in the program, but the beginners will also have a field day. An important part of every LinuxDays year is boots with with the representatives of the Czech and foreign projects.
This year, several foreign lecturers, who are experts in their branch, will perform. Vojtěch Pavlík, a Linux kernel developer, and Norwegian security expert Per Thorsheim also accept the invitation.
You can chat with community members or developers of popular apps at community boots. There will be also an opportunity to pass the exam and get an internationally recognized LPI certification.
The program of the conference includes FIT lectures:
The conference is suitable for open-source enthusiasts, it offers lectures for both beginners and professionals. Participation is free of charge, but you need to register. All necessary information is available on the conference website.
The event is organized by Petr Hodač with the support of the Faculty of Information Technology of CTU and the CTU Student Projects Fund. Furthermore, the Root.cz news server or representatives of Fedora, Gentoo and openSUSE Linux distributions participate in the event. The conference will take place at the Dejvice Campus in the New Building CTU – Thákurova 9, Prague 6.
Main Organizer of LinuxDays
System Administrator at the Office of ICT Services


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Silverstar! Speaker Cable
SIlverstar! Speaker Cable:
The Silverstar! Loudspeaker cable uses an inner-core layer of mixed conductors (1/2 Silver-Plated Copper + 1/2 Bare Copper) and arranges them in a coaxial dual-tube arrangement with an outer-core layer of bare pure copper. This is based on a dual-layer maypole braid with braided nylon-multifilament fibers between the layers. Each polarity sums to 12awg!
Terminated with XOX direct gold-plated pure copper banana connectors.
All of our cables are made to order by Chris Sommovigo, personally. Please allow 1-3 weeks for shipping.


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Gaining An Edge: Do you know why RFPs are structured as they are? Many do not. Following is a brief introduction as it is essential to government contractors to be well versed in the structure of RFPs. The first time I sat through a review of a federal government RFP I thought "What in the world?" I was wet behind the ears so I didn't say anything, faking my understanding of the prescriptive nature of government RFPs. But damn it was odd. Folks were bouncing all over the place talking about B, C, L and M and other sections just like they had their own alphabet. Odd, they never got past M. I did the count, not even having to use my fingers, and there were exactly 13 letters after M not used. There were also exactly 13 letters from A to M. Is this relevant or just the way it worked out? Is this one of those numbering structures that leaves you befuddled? For those that know the Bible, there exists a very unique structure. Psalm 117 is the shortest chapter in the Bible and Psalm 119 is the longest chapter and Psalm 118 is exactly in the center with 594 chapters before Psalm 118 and 594 chapters after Psalm 118, with the total of 594 and 594 equaling 1,188 or Psalm 118.8 which is the exact center of the Bible. Darn if I know if a unique scheme like this was intended for the FAR, but if it was, I'm sure going to pay more attention looking for other oddities. Perhaps if I read it backwards I would glean some useful insight? Upon reviewing the RFP I thought to myself, "Who decided this?" No way was I going to ask. By continuing to listen, asking an innocuous question here and there, aided by some research (acquisition.gov/far/), I discovered a government handbook called the FAR (Federal Acquisition Regulation) that describes in detail how an RFP is to be structured. The exact chapter and verse is FAR 15.204-1 Uniform contract format. FAR 15.204-1 is also the descriptor of the resultant contract to the awardee. FAR 15.204-1 presents four major parts of the government's acquisition document: Part I Schedule; Part II Contract Clauses; Part III List of Documents, Exhibits and Other Attachments; and, Part IV Representations and Instructions. All four parts are required to be included in a solicitation, though only Parts I, II and III are included in the contract with Part IV saved in a contract file and incorporated by reference in the contract. Each RFP section stands alone yet interfaces with other sections in an intricate manner, leaving the uninformed, or perhaps non-federally educated individual perplexed. How these and other sections are versed, and interpreted, can make a material difference in which company gets an award. Should you not clearly understand the makeup of an RFP, I would suggest you seek assistance through a consultant or other body. Reading Subpart 15.2 in entirety will be well worth your time. Stay tuned for upcoming posts on each skill/attribute of a bonafide Business Development Director provided by Bob Lam. Bob is the principal and founder of Bob Lam Solutions and is affiliated with GovFlex. Preview Bob's book People Buy From People, Navigating the Federal Highway at his website BobLamSolutions.com or go straight to Amazon.com/books for a copy. [/vc_column_text][/vc_column][/vc_row]]]
Where Is the Request For Proposals (RFP) Defined?
Interested in any of these federal business opportunities?
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Why so many liquor stores?
When I was little and my dad drove around with me near our house in West Oakland, he used to point out how many liquor stores and churches were right across the street from each another. Riding with him through a city like Oakland, we could almost make a game of it. But I didn't know if he would find the game funny, so I never brought it up.
I've noticed the same thing in low-income neighborhoods from San Francisco to Seattle to Washington. I asked my uncle how there could be as many liquor stores as churches. He replied, "Because they want us to live life on our knees."
I always wondered who "they" are. Is it the imperial business owners who sometimes establish ghetto chains of "likka stoez" all in one neighborhood? Or is it the planning department that green-lights the development of the stores?
The issue has been in the news because several black men vandalized an Oakland liquor store and allegedly threatened the store owner for "poisoning the black community." The media spared no opportunity to show the footage, and prosecutors are painting the culprits as terrorists.
But I look at the situation through a different lens. Some of these stores add to community problems such as public drunkenness and domestic violence with liquor discounts and lax rules that make it easy to get drunk and get alcohol without being ID'd. And if you do get ID'd, fret not -- just walk down the block.
Before I turned 21, I could get a tall can of malt liquor for less than a dollar. Or I could pick up a Paul Masson brandy for $4 and a 50-cent soda to mix it with. I didn't run out and terrorize the streets of Oakland (although I did act rather foolish). But I know people who do and have run amok, and "likka stoe" specials have been the recipe for that hyper rowdy activity.
These stores' bottom line is people's consumption of candy, sodas, single cigars, cigarettes, stale donuts and withering fruits. They promote our unhealthy lifestyles with advertisements and deals. In my neighborhood, if I want to go to a grocery store with a real produce department, I pass at least five liquor stores on my way. If an area heavily saturated with fast-food restaurants is vulnerable to health problems stemming from obesity, it's no wonder areas with a lot of liquor stores experience higher violent crime rates -- a link established by a recent study from the Prevention Research Center.
So I have to ask why liquor stores, and not Starbucks, are booming in our neighborhoods. People come to these neighborhoods from miles around certainly not for the lattes. Store owners say they're just serving a demand -- that the real poisoners are drug dealers hanging around these stores just as much as the winos. But the notion of "discount liquor" sounds like drugs at a deal. So maybe the planning department shouldn't be putting so many of these drug dealers all in one place. The department needs, instead, to approve more real grocery stores and other businesses that build the community, not profit from -- and contribute to -- its decline.


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I attended a County of San Diego seminar featuring Sonara Carter-Barber. I was immediately and consistently impressed throughout the seminar. She has a refreshing way of connecting with the audience and presenting sometimes-difficulty subject matter with ease, grace and humor, making learning fun and engaging. I cannot wait for her next seminar.
Marchita Masters, Psy.D, Clinial Psychologist
"Mrs. Carter-Barber is brilliant at conveying the value of music as Expressive Arts Therapy. Sonara's 'Let the Music Play' presentation validated the members' love of Music to energize their career passions. Sonara's ideas resonated with all of the SBPA's members who come from diverse backgrounds and experiences. The SBPA members now passionately uplift the lives of business, education, healthcare, technology and other professionals." John Nemoto, Chair Marketing Committee South Bay
Professional Association, Torrance, CA.
"A consultant is defined as; an expert who charges a fee for providing advice or services in a particular field. I have worked with Sonara Carter-Barber for over ten years. We have collaborated on more than twenty (20) projects while working with the Community Renewal Summit. This project is a California State-wide initiate to improve living conditions throughout the State of California and beyond. I can attest, without hesitation, Sonara is a true professional; her advice and professional services have always proved to be invaluable to the projects that we have worked on together. She exceeds the call of duty with zest to make sure that every detail is handled well and in a timely manner. Her spunky personality and exuberant energy sets her head and shoulders above the rest of her peers!"
Mac McGee, MBA
Retired ACT Executive Director
"I'm working with Sonara Carter-Barber to spread the word about the benefits of the Raw-Food Lifestyle. In the times that we've met, she has introduced to me a way of thinking about the marketing my business that will create lasting relationships and serve the highest purpose of my company's mission. Many of the concepts she introduced to me effectively market my company. That impresses me more than anything else. It's refreshing to meet a professional that is more concerned about efficacy and economy of my marketing efforts over her own financial gain."
Joan T. Jackson, Esq.
Founder of Living Raw


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Aussie author wins international business award
Cadence: A Tale of Fast Business Growth by Australian small business owner Pete Williams was named the winner of the Gold Medal Award in the Best Business Book category in the 15th Annual International Business Awards this week.
The International Business Awards are the world's premier business awards program, receiving over 3900 nominations from 74 nations and territories.
Cadence is a parable based on a true story and traces the journey of a business owner and triathlon coach named JJ who left his stable job as a teacher to fulfil his dream of becoming an entrepreneur. Unfortunately, two years after opening his bike shop, JJ finds himself in a place that is all too familiar to most business owners ― struggling to stay afloat.
That all changes, fast, when an athlete he coaches teaches him how to turn the store's profitability around with seven key "10% Wins."
"It's such an honor to have a little book from Australia make such an impact on a world stage," Williams said. "I'm in trenches every day running our business, so to see this story and lessons helping other entrepreneurs around the world is amazing."
Cadence communicates Williams's "7 Levers" approach to business growth through the vehicle of a story. Instead of offering a list of do's and don'ts for business success, Cadence imparts wisdom by inviting readers on a journey into the lives of two characters who each have something valuable to teach the other.
A Southern Region Finalist in the Ernst & Young Entrepreneur of the Year Program, a Small Business ICON (Best-in-Class) Recipient, and an Australian Business Award Winner for Marketing Excellence, Pete Williams is the co-founder of numerous businesses across varying industries — from Infiniti Telecommunications to SimplyHeadsets.com.au. Pete is also a Professor-of-Practice at Deakin University.
More than 3,900 nominations from organizations of all sizes and in virtually every industry were submitted this year for consideration in a wide range of categories, including Company of the Year, Marketing Campaign of the Year, Best New Product or Service of the Year, Startup of the Year, Corporate Social Responsibility Program of the Year, and Executive of the Year.
The Award winners were determined by the average scores of more than 270 executives worldwide who participated on 12 juries.
"This year's award winners in the IBAs are the most distinguished group of winners we've had yet," said Michael Gallagher, president and founder of the Stevie Awards, who runs the IBA program.
"We raised the minimum average score from the judges required to qualify as a winner, so 2018 winners should be especially proud of their achievements. We look forward to presenting to them in London on October 20, and to tell their stories over the coming year."


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text: Michael Freeman received a BA in Biology from Siena College and his Doctor of Medicine degree from Albany Medical College. He joined the MA Program while a Fellow in the Division of Pediatric Nephrology at Children's Hospital of Pittsburgh, and wrote his thesis: The Ethical Implications of Emerging Genetic Predictors of Poor Organ Transplant Outcomes. He is now Assistant Professor of Pediatrics at the Pennsylvania State University College of Medicine. Michael Freeman's Faculty Webpage