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Dorlin, aged 17, won the club-level Michelin Clio Series title (for older generation Clio Cup machinery) with Westbourne in 2016.
Now though comes the challenge of the UK Clio Cup – recognised as the ultimate proving ground for young drivers looking to a career in the British Touring Car Championship.
It is at the BTCC's high-profile events that the UK Clio Cup races. Each event attracts huge trackside crowds (average 38,000+ in 2016) as well as vast levels of live free-to-air TV coverage on the ITV4 channel.
"It's quite a step up – the grid is for the very latest specification Clio Cup race car produced by Renault Sport and the events are on a totally different scale to what I'm used to," commented Dorlin.
"However I'm not daunted by it. I've tested the car a few times and seem to have been setting some good times and Westbourne have won in the UK Clio Cup in the past so I know, having already formed a very good relationship with them, that I've got the right team behind me.
"I've also seen how quickly Paul Streather got on with the UK Clio Cup when he progressed to it – I had some good races with him in the Michelin Clios in the past and I'm looking to achieve similar things. In theory 2017 will be a learning year ahead of a much bigger push in 2018. I want to finish the season inside the top ten at least."
Dorlin's announcement comes after fellow Yorkshireman Myles Collins (Harrogate) confirmed on Friday he had also signed to race for Westbourne in 2017.
Richard Colburn, Team Principal of the West Sussex-based squad, said: "We're delighted to be working with James again in 2017 – he proved to us what a very exciting young talent he is in 2016 and I have no doubt he will quickly be towards the sharp end of the grid. We have some decent pre-season testing planned so we can hit the ground running at the first two races at Brands Hatch in early April – these can always prove very important to how the rest of your season unfolds."
Renault Sport's UK Motorsport Championship Manager Will Fewkes added: "We very much welcome James to the UK Clio Cup. Indeed a Dorlin-Westbourne combination has the potential to be one of the revelations of 2017… It's also really nice to see Westbourne's plans falling into shape as they prepare for a return to the championship."


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subset: commoncrawl


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Our posh Mitzie Mink Fur Cape is an excellent design for her who want to look effortlessly cool during the colder months of the year. Genuine mink fur is constructed with layers of lush mink fur sewn on a comfortable knit backing. A full pelt mink fur collar features a magnetic closure at the neck for easy wear. The airy sleeves also feature interior buttons to tack closed. The lightweight appeal is one size fits all in a caped effect making a great gift for any special woman. Adornments include snap button closures and side pockets for a functional style.
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Erickson preaches March 19 at 8:30 and 10:45 services
You are also invited to the adult forum on that date, featuring a question-and-answer format so you can MEET YOUR BISHOP! This is your opportunity to find out about the man, his life, his faith, his job, his hobbies, his calling, or to ask whatever else you've been wondering about your bishop.
The Rev. Paul D. Erickson was elected June 4, 2016 to a six-year term as bishop of the Greater Milwaukee Synod of the Evangelical Lutheran Church in America. We are happy to have him as our guest at Mt Zion on March 19, and we're putting him to work for us!
"I'm excited and hopeful about our future as we continue the work of establishing vibrant faith communities committed to working with God in the establishment of a more just, peaceful and compassionate world," Erickson said. "The Greater Milwaukee Synod has a strong history of creative and faithful ministry, and I look forward to finding out what God has in store for us all as this next chapter unfolds."
Erickson earned a Bachelor of Arts degree from Gustavus Adolphus College in St. Peter, Minn., in 1983 and a Master of Divinity from the Lutheran School of Theology at Chicago in 1989. He also earned a Doctor of Ministry degree in Congregational Mission and Leadership from Luther Seminary in St. Paul, Minn., in 2012.
Wauwatosa roots
He returns to the Greater Milwaukee Synod from St. Paul, where he served as the director of Agora, a ministry that works to develop lay leaders for immigrant and multicultural congregations in Minnesota and South Dakota. Erickson grew up in the Greater Milwaukee Synod, where he was a member of St. Matthew's in Wauwatosa and Bethel in Muskego. From 1993-2003, he served as pastor of Faith/Santa Fe Lutheran Church in Milwaukee, and he was later called as Assistant to the Bishop for Evangelical Mission in the Saint Paul Area Synod, where he served with Bishop Peter Rogness (a former bishop of the Greater Milwaukee Synod) from 2008-2014. He has also served at congregations in Chicago, Ill. and West St. Paul, Minn.
"I have a passion for God's church, God's people, and God's world, and I love exploring new places and finding new ways to connect with others," Erickson wrote in response to a question about the gifts he would bring as synod bishop. "I love to sing, teach, preach, and laugh, and I try to use my gifts in a way that creates a space in which others can be their best selves."
Erickson speaks of his deep love of the ELCA and of the global church, and notes that he has spent much of his ministry working in cross-cultural settings. He also points out the need to find new ways to move forward together as the church, despite our comfort with more familiar approaches to ministry.
Paul and his wife, Lynn (an ELCA pastor serving in West St. Paul, Minn.), have two children: David, 20, and Sarah, 16.


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Call or text us:
+254 721 761 511
+254 727 745 442
+254 725 207 804
Cell phone reception is sporadic in this part of the country. Email is the better way to reach us. We'll get back to you promptly. Thank you.
following projects happened because of visitors to Maasai Simba
Women's Cooperative
Simba Camp supports Merrueshi Women's Cooperative and enabling
them to make high quality products for the world markets. We
are supporting and inspiring Maasai women artisans to help themselves
through craftsmanship. Click
to learn more about Merrueshi Women Cooperative
for Maasai High School and Merrueshi
Primary School is because of visitors to Maasai Simba
Camp. We have 500 students, boys and girls in our schools. Our
students have never been to the outside world. The students
would enjoy hearing your life experience(s) as a westerner.
Most visitors consider the visit to our schools a life-changing
experience. Click
to learn more about Maasai Schools funded in part by funding
from Maasai Simba Camp.
High School Students
Village Clinic
Village Clinic is providing basic healthcare services to nearly
5,000 Maasai residents of Merrueshi and the surrounding communities.
You'll visit the clinic with guides and meet our medical
team. This experience will allow you to learn about successes
and challenges of running a rural health center in Africa. Traditionally,
the Maasai depended on medicinal plants for treatment. However,
with a rapidly changing climate and culture the Maasai traditional
diet of meat, milk, and blood has changed. Visit our clinic
and learn more about the Maasai in a new world of western medicine.
Click to learn more about Merrueshi
Village Clinic funded in part by funding from Maasai Simba Camp.
Restoration Project
Waterhole Restoration Project in Merrueshi Group Ranch is aimed
at restoring natural waterholes for the benefit of wildlife
and Maasai pastoralists. Click
to learn more about the Waterhole Project funded in part by
funding from Maasai Simba Camp.
learn more about all these projects go to: Maasai
Simba Camp | P.O. Box 231 |
Emali, Kenya |
All rights reserved
You make a difference!
Your stay with us helps support our ongoing efforts to empower the Maasai so that we can make better-informed decisions that affect our destiny.
it is not a must visitors are welcome to bring soccer balls, pencils,
rulers, crayons, and chalks for students. You can hand deliver
the items to students and teachers when we visit the school.
& Habitat Conservation Project
objectives for restoring waterholes are to:
Collect rainwater which would otherwise be lost to evaporation
or runoff
• Reduce human and wildlife conflict over shallow wells
and boreholes
• Promote tolerance and harmonize the relationship between
people and wildlife
• Secure wildlife migration corridors in private ranches
• Increase the number of wildlife in the area
We are proud members of Pack for a Purpose, an initiative that allows travelers like you to make a lasting impact in the community at your travel destination. If you save just a few kilos of space in your suitcase and bring supplies for area schools or medical clinics in need, you'll make a priceless impact in the lives of our local children and families. Please click here to see what supplies are needed for our project/projects.


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The summer before I started university, I did a few creative writing workshops. Once, we tried some verse poems (I wrote a villanelle). I liked following a template. It gave me a guide in the otherwise limitless and daunting realm of poetry. So I thought I would try it again for this week's post. This time, I tried a pantoum. I followed the format of Another Lullaby for Insomniacs by A. E. Stallings as… Read More
Boy, I will do anything for a bit of alliteration. But alliteration aside (see what I did there?), today I am coming to you with some thoughts about comparison. I'm sure most of us have subjected ourselves to this at one point or another in our lives: looking at ourselves, or at something we've done, and undermining it because someone else is further or seemingly better off. In my first year of university, I lived… Read More
Some elements that make a good story, in my opinion, with some examples that show those qualities. 1. Storytelling I believe a good story requires a good balance between revealing and withholding information. If everything is given away too quickly, the reader may lose interest, and the same thing may happen if the story goes on and on with nothing to capture the reader's interest in the first… Read More


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Effective Consulting Skills Course
Small Business. Big ideas for small business.
Many professionals enter the consulting profession without realising the skills required to build an effective practice. These professionals need specific consulting skills to solve the problems they are asked to fix and/or to realise the opportunities which their clients may have. By having the right abilities, consultants and clients will achieve the desired outcomes intended.
This course aims to provide you with the techniques necessary to develop effective client relationships and improve consulting delivery skills, in order to ensure the success of your project/s.
By the end of this course, you should be able to:
- articulate a definition for consulting, and your role as a consultant (coach, expert, facilitator, mentor, trainer)
- communicate a summarised five-phase process for your consulting projects
- prepare for each project by identifying key stakeholders and clarify expectations of agreed success criteria
- design in-depth diagnostic approaches for identified problems
- develop and evaluate alternative solutions for problems
- logically communicate recommendations and actions to problems while managing any resistance or objections to solutions
- plan and monitor implementation with guidance on dealing with any required change
- withdraw safely when the project is finished.
What is consulting?
- The importance of consulting
- The role of the consultant
A five-phase consulting process
- Phase 1: Preparation and planning
- Phase 2: In-depth diagnosis
- Phase 3: Finding the solution
- Phase 4: Implementation
- Phase 5: Termination
Phase 1: Preparation and planning
- Establishing client relationships
- Preliminary problem diagnosis
- Assignment methodology
- Assignment plan
- Validate original proposal
- Consulting contract including criteria for success
Phase 2: In-depth diagnosis
- Designing the diagnostic framework
- Defining necessary facts incl. data planning
- Gathering and validating data
- Data analysis and synthesis
- Feedback to the client
Phase 3: Finding the solution
- Searching for ideas on possible solutions
- Developing and evaluating alternatives
- Communicating recommendations, actions and implementation plan
Phase 4: Implementation
- The consultant's role in implementation
- Planning and monitoring implementation
- Training and developing client staff
- Guiding principles for introducing change
- The levers of change
Phase 5: Termination
- Planning for withdrawal
- Evaluation and sign-off
- Follow-up
- Final reporting
Intended audience
Suitable for professionals who intend to work as a consultant, by either:
- setting up and operating as a sole practitioner (ie sole trader)
- starting or joining a boutique consultant
- joining a brand-name firm.
Delivery style
Delivered as a workshop, with facilitated discussion, activities and exercises. You will be provided with a workbook during the course and each session will have its own activities (22 in total).
Before the course
You should have a consulting project in mind. Either one that you would like to do, or one that is already in progress. All of the course activities and exercises will be relatable to that consulting project.
- Expert trainers
- Central locations
- Free, expert advice
- Course materials – yours to keep
- CCE Statement of Completion
Related content. Further your learning.
- Arts and humanities
- Business and management
Horticulture and gardening
- HSC preparation (years 10-12)
Human resources
Information technology
- Adobe
Computer basics
Data analysis and analytics
- Microsoft
Web development
- Language and culture
- Marketing
- Music and film
- Project management
- Psychology and psychiatry
Public sector


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Can a business think of a mobile presence barring Android apps? No, they cannot simply because a majority of mobile devices worldwide are built on Android, and the platform enjoys the largest market share in the mobility market. As a business, if you are looking for an Android app development company with a global clientele and years of experience and proven exposure, your search just ends here.
We boast of a strong team of most accomplished Android app developers having already built an array of customer centric and sophisticated apps for various business niches. Over the years, our mobile app developers have produced countless popular Android apps for various enterprise and consumer niches. We are considered now as one of the leading companies in Android app development India could ever produce.
We as one of the sought after Android app development companies in India boast of a robust team of skilled professional developers ready to build most sophisticated apps with latest features and unique designs. Some of the key Android app development services we offer include the following:
We believe in offering UX and UI that stands out in respect of ease of use, engagement and attributes that make apps ready to cope up with the future changes quickly. We built many of the most versatile and flexible Android apps for a diverse array of business niches. From the robust pool of talented Android app developers for hire to a proven track record of making a significant contribution to companies with our mobile development, there are many reasons to choose us for your Android app development project or to hire Android app Developers from us.
We have a pretty large team of leading Android developers from the industry having the unparalleled excellent track record of delivering an array of most successful apps across several business niches..
We just do not build an app, but take care of the whole lifecycle of development process starting from the conceptualisation to prototyping, from design to coding, from testing to deployment, from marketing to maintenance and support.
The sole objective of our development process is to deliver stand-apart user experience with a principal focus on ease of use, quick engagement and business conversion.
We follow agile development process with concurrent testing to leave no scope for performance and design glitches.
We also assign dedicated Android developers team along with a project manager for every project and always ensure keeping our customers informed and updated about the project milestones reached during development.
Thanks to the agile development process and our unflinching commitment to satisfy customer needs, we invariably meet project deadlines without really needing to compromise on the app performance and user experience.
For each of our apps we offer solid post-development support and our strategists and marketers remain ready to help apps attain growth and achieve traction in app marketplace.
Are you planning to build your new Android app? Do you feel only professional developers with proven excellence and track record should be given the project? Well, to know more what it takes to build a successful app and how IndianAppDevelopers can just make your dream come true, just send us an email or drop us a message and we will be in touch with you just in minutes.


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Uncertainty about the outcome of the Brexit negotiations has hit new highs, President Trump seems determined to scare the markets witless with his threats of escalating the trade war, debt problems in China are accelerating – the perfect background for a contrarian 'buy' signal.
Tag Archives: US equities
'Buy' signal triggered by extreme bearishness
It finally happened: investors are so bearish that a contrarian "buy" signal has been triggered. The Bull and Bear indicator developed by researchers at Bank of America Merrill Lynch is finally indicating Buy, one year after climbing so high that it triggered a Sell signal.
Capitulation is near, and so is the Buy signal
If this is not yet capitulation, it sure feels like it. Money has been fleeing stock markets at record speed, and despite dovish signals from the Federal Reserve, investors are still not taking advantage of the buying opportunities the panic in the markets are throwing at them.
As 'exodus from Europe' intensifies, watch the UK savings ratio
The list of reasons to worry in the market is growing longer by the day, and investors keep taking money out of risky assets – among them, European ones.
The phenomenon has been dubbed an "exodus from Europe" by analysts at Bank of America Merrill Lynch, who say there is "no surprise that the outflow from European high grade and high yield funds has been much more sizable than outflows from emerging markets debt funds."
Will Green November follow Red October?
Last month has become known as Red October, not so much as a hint to the film starring Sean Connery as the commander of the defecting Soviet submarine by that name, but sadly, as an accurate description of the dominant colour on trading screens around the world.
Don't do all your stock market shopping on Halloween
The Halloween effect is a well-known seasonal quirk that pushes stock prices up between October 31 and May 1. After a horrible October for stocks, investors are anxious to know whether the market rout is over or it has more to run.
There is one indicator that could provide some clues. We've spoken about it before on this website. Bank of America Merrill Lynch's Bull and Bear indicator triggered a "Sell" signal back in January of this year, and it is now close to a "Buy" one – although not yet.
'Schizophrenic' capital flows? No, they're perfectly rational
The year-to-date capital flows seem to show a dramatic change in the way investors perceive risk in the stock markets. Emerging market equities, Japan and the financial sector seem to have turned from risky assets into "safe havens".
Indicator that predicted the selloff is back to neutral
The indicator that correctly signalled February's selloff has fallen below the trigger for the Sell signal, but this does not mean the path is clear for those who are tempted to buy stocks now.
A 'Powell put' is not guaranteed for the markets
Everybody is waiting for Jay Powell, the new Fed Chair, to set out his vision this week. The main question is: will there be a "Powell Put" just as there has been a Greenspan put, a Bernanke put and a Yellen put?
Sell signal still flashing despite the stock market correction
The past week has not been encouraging for investors, with many asset classes haemorrhaging funds at increased speed.
The week before that, on January 30, the Bank of America Merrill Lynch's Bull/Bear indicator triggered a sell signal for the first time in five years, and markets sold off.


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Blurred Boundary #1 (2017)
Carbon Nature
Carbon coated seed pods. Strung from copper threads. Hanging on a burnt branch. They clash in silence, but their contact is detected. What follows? Must every physical interaction have digital consequences?
This work was collected, painted and assembled during a one-month "residency" in the Hybrid Craft Lab at the Hebrew University in Jerusalem, Israel.
I collected these seed pods in the park on may way between home and the lab.
Painted them in Bare Conductive's carbon paint.
Strung them from Karl-Grimm's copper thread.
One day I broke off the branch from a burnt bush.
The consequences are still missing.
Video from first prototyping with sounds:
Smaller version:


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We left the winning run stranded on second base and lost the game. We watched the other team celebrate as we collected our bats, balls, and equipment. In my postgame talk, I was harsh with the team of teenage boys. I told them we lost the game. That's right. I admit it – I used the word lost.
I did not say we were victory challenged. I did not say we won but not as much as the other team. I avoided terms like "moral victory" and stayed away from blaming the umpire. Heck, I didn't even say the boys were winners in my eyes. I simply stated the fact and expected the team to survive.
Fortunately no one melted. No one had to retreat to his safe space. The sun actually came up the next day but I did look out my window before leaving the house to get the morning paper. I wanted to make sure the paid protesters were not lurking about.
Can we agree the polls were wrong for the presidential election? If so, doesn't it mean Hillary Clinton was never really ever the favorite to win? Then why do the media insist on positioning President-elect Donald Trump's victory as an upset? In order to have an upset win, the chances of losing must be legitimate. Words mean something.
The media lives in a bubble of self-importance sprinkled with seeds of ego. Students on college campuses not realized, despite what Mommy and Daddy may have said, the world does not revolve around them.
Both of these groups need to get a grip and grow up. Schools should expel any student who needed to take a day away from classes because of the presidential election results. Chances are those students will not survive the workforce. Members of the media should curl up in the fetal position and catatonically rock back-and-forth. It will be the most useful they have been for their readers in the past decade.
Most students come out of college wanting to change the world. Someone needs to tell them they can't do it by holding their breath and hoping someone does it for them. The media is having a hissy fit that President-elect Trump is "breaking with tradition" by not having pool reporters follow him around.
The media is no longer relevant. Their relevance went down the drain when they flushed objectivity during the campaign. President-elect Trump owes the media nothing. Society owes the bedwetting students nothing.
Both groups must come to grips with a new concept: Earning the right.
Students must earn the right to be heard by actually accomplishing something first – a real accomplishment – not a participation trophy accomplishment. The media must earn the respect of its readers by covering the news objectively – not making the news, being the news, or opining on the news. Just cover the news even-handedly and the audience will return.
The media, like the students, cannot demand respect. They must earn it.
The same is true for the political elite. This shameless group of charlatans is wringing their hands and demanding respect for the disenfranchised Clinton voters who are presumably barricading themselves in homes, caves, and the nearest Starbucks. Meanwhile they show no respect for the Trump voter – only contempt.
My father always told me "You do not get respect, until you give respect." If students want respect they need to give respect. If the media wants respect, it needs to earn it. If the political elite wants respect from all voters it needs to give and earn it.


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All Class 1 drivers post up width and length of your rig. Wheel nut to wheel nut.
Looking through the guideline rules there is nothing about Wheel base but I am curious where we all sit.
The only one that would help give some direction is the width of the gate, the last guideline.
Class-1 "Street" Details:
• Vehicle must have a windshield that fills the entire windshield frame.
• Full width bumpers are required on the front and rear of the vehicle. Bumpers that are molded into the body qualify. A rear bumper is not required on a flatbed, but adding one to the flatbed will gain the additional scale points. (Bumpers are measured from the outsides and must be the width of your windshield).
• Wheels must be aligned within the body wheel wells (center of wheels to center of wheel wells +/- 1/2 inch total combined)
• The vehicles body must be mostly intact. Only mild trimming such as flairs & removing a hardtop are allowed. If the hardtop is removed, a full interior is required (no extreme trimming of bodies allowed *See below.)
• The tread of the tires cannot extend outside of the wheel wells more then 1/2 of the tread width, flairs can be added to reach min. spec.
• Vehicle must run a full length rail chassis (The rail chassis must be as long as the vehicles wheelbase) (Tamiya CC-01 chassis are allowed).
• Truggies are not allowed, flatbeds with full length rail chassis are allowed. The bed must be as wide as the cab the entire length of the bed. Cab only not allowed.
• Tires can never extend beyond the body's bumpers or the rear of any truck bed. (Any stingers, fairleads, shackles, bolts, etc are not considered part of a bumper when determining this.)
• Dovetailing is not allowed.
• Sectioning or narrowing of the body is not allowed.
• Bobbing a truck bed is allowed, but must follow all body specs.
• Boat sides are not allowed.
• 106mm / 4.19" Max tire size including spares.
• Gates will be a minimum of 11" wide (so mind your width).


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One, how to revise civil law before take an examination of?
1. Guiding ideology: (to this book character) do not see affirmation do not pass; Those who look is too careful also do not pass.
2. Macroscopical hold teaching material: Topical, person counterpoises, content counterpoises, creditor's rights, right of inheritance, tort. (among them, occupy topically 35%- - 40% )
3. What is the content of true scrutiny wanting a young animal? (key: Classify a problem)
(1) the classification of civil rights (2) . The classification of civil action (3) . Acting classification (4) . The classification that person counterpoises (5) . The classification of debt (6) . The classification of content (7) . The classification that content counterpoises (8) . The classified above of tort the very key that 8 problems are this book! Above all, classify a standard; Next, substantival meaning; Finally, understanding is divisional its meaning.
4. Become true problem appropriately.
2, the key in civil code key!
1. The equal principle in the basic principle of civil code.
2. Civil law concerns:
(1) ability of natural person right, conduct competence.
(2) custody.
(3) declare is missing, declare dies.
(4) protect touch a clause to disable; Bright for the affiliation solid disable for leasehold clause.
3. Acting limits.
4. Break down of litigant actual effect and interrupt 5. The effigies authority in person authority and privacy counterpoise 6. The drawing in creditor's rights and confuse sth with sth else.
7. Tort liability returns mediumly duty principle, liability of 8 big special tort
Origin: Beijing from study a hot line
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From; Author:Stand originally


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Welcome to the sup boarding school in Lagos
Stand up paddle surfing – is a popular in the world and only gaining momentum with us, the kind of water sports that has come from classic surfing. SUP has become an indispensable friend to surfers in the absence of waves, since you can surf on absolutely smooth water using an paddle.
You do not need special training and, do not even have to be able to swim. Even a child will cope with SUP in 5 minutes. Of course, to confidently stand on two legs or "kite" on the crest of the wave, you will need some time. But you can ride on your knees or sitting from the first minute. This is much easier than windsurfing, because on SUP you can ride not only in the absence of wind, but even against the current.
SUP boards in Lagos are reliable and safe
Surfboards with a paddle are of two types: stiff and inflatable.
Hard boards can be made of different materials: wood, fibreglass, epoxy, carbon mass, but all of them are different – the size always remains unchanged.
Because of this, hard boards are more difficult to store and transport, because they can not be "deflate" as inflatable, rolled into a tube and put in a backpack.
As for inflatable boards, they are also not as simple as one might think (this is not a "water mattress" for you).
Inflatable boards under a layer of heavy-duty composite shells contain a lot of vertical tubes, which give the board in the form of rigidity and strength.
Inflatable boards are slightly inferior to the hard ones in speed, but they can easily be moved in a bag, and besides inflatable boards are not threatened with chips and scratches.
Board construction and additional equipment
On the board itself, the nose and tail (stern) are distinguished, which can give the board different shapes (narrow, round, uneven, etc.).
The bottom of the board there are from one to three fins, they play the role of the stabilizer of the course stability and allow maneuvers.
Top of the board there is an anti-slip pad for the convenience of standing.
On the stern of the board there is a special fastening for the safety cord, it is also called leash. The cord isattached to the leg with a special cuff (velcro).
And it is needed to ensure that the board does not swim away from you, if suddenly you fall into the water (because the board is very light and the waves can quickly carry it away).
Also on some boards there are additional fastenings for personal things in the form of a grid or carbines, and a ring for towing (it is possible to "cling" to the boat).
Our school is located in a very attractive and beautiful location on the main beach of the old town of Lagos.
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text: Sometimes I listen to The Hype Machine. Sometimes, like now, I will listen to the "latest" songs, some of which are unbearable, and I will hit "next" at the bottom right of the screen. In any case, here's a song called Perfect Fit, by a band called Clue, that reminds me a little bit of Islands.


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This shortcut is used by 23 programs in our database.
There isn't any generic description for this shortcut.
What this shortcut does in different programs?
All programs using this shortcut, by category.
Apple macOS - Open the Utilities folder
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The professional hub for online networking, has set its sights on a new audience: the B2B content marketer.
According to the leaked LinkedIn strategy document, the company is looking to build a "comprehensive B2B marketing platform." This new plan includes reforming the current networking space into a place where B2B public relations professionals and business owners can share targeted and dynamic content that generates sales leads.
Entrepreneur outlines the three things you should know, as a content marketer, about the new LinkedIn:
- Taking the Guesswork Out: Content marketers will not only have access to the vast and comprehensive network of LinkedIn, but also the ability to target key audiences more accurately, and measure the impact of the marketing efforts.
- Pressure is On: With this change comes the challenge of executing campaigns effectively. Marketers will need more content, and not just in volume. Due to the targeting features, the content will also need more specifics.
- Reevaluate and Revise: It's time to take another look at your content marketing strategy and determine what it is missing in order to take full advantage of the new LinkedIn features. Rethink your key audiences. Is there an audience you're missing? What information would they want? Content should be created for a potential lead at every stage of the purchasing process.
Once you've revised your social strategy, developed more content, and determined your key audiences, it is time to implement.
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Don't have time to take advantage of all LinkedIn has to offer for your franchise or B2B company? Ripley PR has the knowledge and skills to help you generate new sales leads through B2B social media and comprehensive public relations strategies.


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Massachusetts Personal Injury Settlements and Structured Settlements
If your Massachusetts personal injury case has resulted in a substantial settlement, a structured settlement makes for a great option. Structured settlements provide for payments of your settlement over the course of a number of years. Here is a great blog authored by John Darer which provides an abundance of information regarding structured settlements. Check it out!


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Through the previous week many citizens of South Africa found themselves hooked on a stay broadcasting of debates between Parliament's Committee on Finance and parties for and towards a invoice that is imagined to combat financial crime. More particularly, IEB college students will spend one week at LSE's headquarters where they will be attending lectures on economic and monetary issues, enabling them to additionally experience the fact of one of the principal worldwide financial centres on the earth.
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Article Text
Background Non-invasive monitoring of epidermal growth factor receptor (EGFR) mutations conferring sensitivity and resistance to tyrosine kinase inhibitors (TKIs) is vital for efficient therapy of lung adenocarcinoma (LADC). Although plasma circulating cell-free tumour DNA (ctDNA) is detectable at an early stage, the size of the tumour does not strongly correlate with concentration of whole cell-free DNA (cfDNA), including normal leucocyte DNA. We sought to examine the clinical features of patients with LADC whose cfDNA examination held clues for analysis of cancer genomics.
Methods Forty-four plasma samples from 37 patients with LADC receiving EGFR-TKI therapy, including 20 who developed resistance, were prospectively subjected to droplet digital PCR-cfDNA analysis to detect EGFR mutations and analysed according to clinical features.
Results cfDNA samples from 28 (64%) of the 44 samples were positive for TKI-sensitive mutations. Samples from 19 (95%) of the 20 EGFR-TKI-resistant patients were positive for TKI-sensitive mutations. In 24 patients without TKI resistance, 7 (54%) of 13 patients with regional lymph node metastases, 4 (67%) of 6 patients with advanced T stage (T3 or T4) and 8 (57%) of 14 patients with extrathoracic disease progression were also positive for TKI-sensitive mutations. cfDNA analysis from patients with acquired TKI-resistance disease or extrathoracic disease progression correlated with a high detection rate of TKIsensitive mutations (acquired resistance: risk ratio=2.53, 95% CI 1.50 to 4.29; extrathoracic disease progression: risk ratio=5.71, 95% CI 0.84 to 36.74).
Conclusions cfDNA in patients with EGFR-TKI-resistance or extrathoracic disease progression may be useful for analysis of cancer genomics.
Trial registration number UMIN 000017581.
- lung cancer
- EGFR tyrosine kinase inhibitor
- acquired resistance
- circulating cell-free tumor DNA
- digital PCR
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Statistics from Altmetric.com
- lung cancer
- EGFR tyrosine kinase inhibitor
- acquired resistance
- circulating cell-free tumor DNA
- digital PCR
Key question
What is already known about this subject?
Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) for advanced EGFR-mutant non-small cell lung cancer (NSCLC) represents a drastic change in treatment paradigms.
Tumour genotyping using circulating plasma cell-free DNA (cfDNA) has the potential to allow non-invasive assessment of EGFR secondary mutation, while many existing assays are cumbersome and vulnerable to false-negative results.
We previously established a droplet digital PCR system to quantify EGFR mutations in cfDNA and documented the clinical characteristics of patients with lung adenocarcinoma (LADC).
What are the new findings?
We explored the clinical features of patients with LADC whose fraction of ctDNA within the total cfDNA was high.
We found TKI-sensitive mutations in most of the cfDNA samples obtained after confirming resistance.
cfDNA obtained from patients who developed extrapleural tumours without EGFR-TKI resistance also exhibited high plasma level of sensitising and resistance EGFR mutations.
How might it impact on clinical practice in the foreseeable future?
cfDNA obtained from patients who developed extrapleural tumours and/or EGFR-TKI resistance also exhibited high detection rates of the EGFR-TKI-sensitising mutation by cfDNA testing.
Analysis of cfDNA from patients with extrathoracic disease progression and acquired EGFR-TKI resistance may be effective for clarifying the unknown molecular mechanisms of resistance.
The identification of epidermal growth factor receptor (EGFR)-activating mutations and the subsequent development of EGFR tyrosine kinase inhibitors (TKIs) for advanced EGFR-mutant non-small cell lung cancer (NSCLC) represents a drastic change in treatment paradigms. Several randomised clinical trials have demonstrated that EGFR-TKI administration results in a superior response rate and longer progression-free survival than platinum-based chemotherapy for advanced EGFR-mutant NSCLC.1–3 However, patients who initially respond to EGFR-TKIs eventually acquire resistance.
The mechanisms of acquired EGFR-TKI resistance have been widely studied and several mechanisms have been identified. The most common mechanism of resistance to TKIs, observed in over 50% of patients, is a threonine-to-methionine substitution within the gatekeeper residue at amino acid position 790 (T790M) of the EGFR gene.4–7 EGFR-independent mechanisms include the MET proto-oncogene, receptor tyrosine kinase (MET) amplification (about 3%–5%), v-erb-b2 avian erythroblastic leukaemia viral oncogene homolog 2 (HER2) amplification (about 8%–13%), phosphatidylinositol 3-kinase catalytic subunit (PIK3CA) mutation (about 1%–2%), B-Raf proto-oncogene serine/threonine-protein kinase (BRAF) mutation (about 1%), histological transformation from NSCLC to small cell lung cancer (6%) or epithelial-to-mesenchymal transition (EMT) (about 1%–2%).6–8 With many negative clinical trials in EGFR-TKI-resistant setting,9 treatment strategies for acquired resistance, until recently, have remained unclear.10 11
The standard of care is rapidly changing with the development of third-generation, mutant-selective EGFR-TKIs that have activity against cells harbouring EGFR T790M mutations.11 12 Osimertinib is 30-fold to 100-fold more potent against T790M and less potent against wild-type EGFR13 14 and is approved for patients with T790M mutation-positive NSCLC (as detected from tissue) who have progressed during or after EGFR-TKI therapy. However, tissue genotyping remains a clinical challenge because of the difficulty of tumour rebiopsy after acquisition of resistance in cases with small target lesions. In addition, rebiopsy may also result in insufficient tumour material for genetic analyses due to necrotic or fibrotic changes. Therefore, minimally invasive tests, known as a 'liquid biopsies', represent a promising breakthrough for detection of EGFR T790M or other mechanisms when disease progression occurs in distant sites, such as the brain, bone or lungs, that are not involved by the primary tumour.15–17
Circulating plasma cell-free tumour DNA (ctDNA), small DNA fragments from apoptotic and necrotic tumour cells or circulating tumour cells (CTCs) into the bloodstream, represents a promising source that inform tumour genetics, mechanisms of progression and drug resistance.18–20 ctDNA is only the portion of cfDNA specifically released from cancer cells, and most of cfDNA is derived from normal cells, including normal leucocytes that undergo apoptosis or necrosis. cfDNA is released by passive mechanisms, such as lysis of apoptotic and necrotic cells or digestion of tumour cells by macrophages, and also by active mechanisms, such as the release of fragments of tumorous nucleic acid into the circulation by living cells.17 21 A new technique known as droplet digital PCR (ddPCR) may become a clinical diagnostic tool for assessing mutations in lung adenocarcinoma (LADC).22 23 Tumour genotyping using cfDNA has the potential to allow non-invasive assessment of tumour biology, while many existing assays are cumbersome and vulnerable to false-negative results. The Roche cobas 4800 system (Roche Molecular Systems, Inc), approved by the US Food and Drug Administration and the Pharmaceuticals and Medical Devices Agency of Japan, is a companion diagnostic system for osimertinib to detect EGFR T790M mutations.24 In addition, comprehensive genetic panel analysis of cfDNA using next-generation sequencing may be useful as a quantitative tool for genomic characterisation to inform choice of therapy.
Although technical advances may further improve the sensitivity of cfDNA analysis, assessment of biological and genomic factors may eventually be limited by the tiny concentrations involved. A range of sensitive sequencing methods is typically implemented in many molecular pathology laboratories. However, very low levels of mutated DNA can lead to a false-positive result and DNA aberrancies do not always represent a cancer clone, or they can produce a false-negative result when the level is below the assay detection limits.24 Therefore, it is necessary to establish more clinically useful sequencing methods for analysing cfDNA from LADC patients. We previously established a ddPCR system to quantify EGFR mutations in cfDNA.25 We explored the clinical features of patients with LADC whose fraction of ctDNA within the total cfDNA was high, rendering cfDNA examination useful for analysis of cancer genomics with next-generation sequencing.
In this study, we investigated the relationship between patient characteristics and the detection rate of EGFR mutations in cfDNA from patients with a histologically confirmed EGFR mutation.
Materials and methods
Study population
Peripheral blood samples were collected from 13 patients with LADC with EGFR exon 19 in-frame deletions or 24 patients with exon 21 L858R mutations after obtaining written informed consent. In addition, peripheral blood samples from two patients with LADC harbouring the 4-anaplastic lymphoma receptor tyrosine kinase (EML4-ALK fusion) gene were also collected for EGFR mutation-free controls, because of the exclusivity with EGFR mutations in lung cancer with ALK fusion. Blood samples from each patient were collected in two 5 mL EDTA-containing Vacutainers and spun to separate plasma within 30 min of collection. Plasma samples were kept frozen at −80°C until DNA extraction. We evaluated the incidence of TKI-sensitivity in patients with histologically confirmed EGFR mutations. Seventeen patients provided cfDNA before EGFR-TKI therapy and 20 provided cfDNA after developing resistance to EGFR-TKIs. Seven of 20 patients also provided blood samples before administration of EGFR-TKI; therefore, a total of 44 blood samples were collected from the 37 patients who developed resistance (17+20+7=44). Most of these patients were subjects in our previous study.25 We collected information about patient characteristics for follow-up analysis. We examined the samples using picoliter-ddPCR to determine the fraction of cfDNA with EGFR mutations and the concordance of T790M mutation status between cfDNA and rebiopsied tumour tissues.
Measures and definitions
cfDNA was extracted from 2 mL of plasma using the QIAamp Circulating Nucleic Acid kit (Qiagen, USA) and quantitated using a NanoDrop spectrophotometer (Thermo Fisher Scientific/Life Technologies) and a Qubit fluorometer (Invitrogen, Carlsbad, California, USA). Reaction mixtures containing 4 ng of cfDNA were subjected to picoliter-ddPCR. Detection of representative exon 19 in-frame deletions, and L858R and T790M mutations was conducted using an assay (TaqMan SNP genotyping assay, Life Technologies) as previously reported.25 Digital PCR was performed (RainDrop Digital PCR System, RainDance Technologies, Billerica, Massachusetts, USA) in which PCR takes place in millions of droplets with volumes of approximately 5 pL.26–28 Compensation factors and the respective thresholds were set based on data from positive-control cell lines (II-18, NCI-H1975, PC-9) to define droplets positive for exon 19 deletions and the L858R and T790M mutations.
Threshold setting for positive detection
To determine the threshold for detecting EGFR mutations in patient's cfDNA, cfDNA from two patients with LADC harbouring the EML4-ALK fusion was used as negative controls because of the exclusivity of EGFR mutations in lung cancer with ALK fusion. Only a few droplets among millions were positive for EGFR mutations. Due to the possibility that a few EGFR mutations could be present even in ALK fusion-positive patients with LADC, the threshold for a positive result was tentatively set to 10 droplets based on the negative control data. Using this threshold, the rate of false-positive droplet detection was predicted to be <0.0002%. The picoliter-ddPCR analysis complies with the essential requirements listed on the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines for ddPCR.29 This procedure was described in our previous study.25
Statistical analysis
Correlation between the ability to detect EGFR mutations in plasma and patient characteristics was calculated using risk ratios and a logistic regression model with the following covariates: tumour stage (postoperative relapse vs stage IV), tumour, node and metastasis (TNM) stage according to the seventh edition of the UICC TNM classification at the time of plasma sampling (Tx/1/2 vs T3/4, N0 vs N1/2/3, M0/M1a vs M1b, postoperative recurrence vs stage IV disease), extrathoracic disease progression at latest imaging (negative vs positive) and resistance to EGFR-TKI (negative vs positive) based on the distribution for the number of patients. Fisher exact test with a significance level of P<0.05 was used to assess the association between the detection rate and patient characteristics. We also calculated concordance rates of T790M mutation status (T790M-positive or T790M-negative) between tissue and plasma. Analyses were performed using commercial software (IBM SPSS Statistics V.24.0).
Detection rate and risk ratio by subgroup in all patients
We examined the relationship between clinical characteristics and detection rates for TKI-sensitising mutations in plasma DNA. In total, we examined cfDNA samples from 37 patients with LADC who received EGFR-TKI therapy: 24 provided cfDNA before EGFR-TKI therapy and 20 provided cfDNA after developing resistance to EGFR-TKIs. In seven patients, samples that acquired both before and after acquisition of EGFR-TKI resistance were analysed. We used picoliter-ddPCR to detect EGFR-TKI-sensitising and T790M mutations in the samples (table 1). Other clinical characteristics of the patients are shown in the online supplementary tables 1 and 2.
The sensitivity of plasma genotyping was 64% (95% CI 56.8% to 65%) for the sensitising mutation for all samples (28 of 44), 60% for exon 19 deletions (18 of 30) and 71% for L858R (10 of 14). The detection rates for TKI-sensitising mutations in plasma were not significantly correlated with sex, smoking status, EGFR mutation status at diagnosis, tumour stage, immediate prior treatment regimen or the type of EGFR-TKI at first administration. The detection rate of TKI-sensitive EGFR-mutations in cfDNA from patients with acquired EGFR-TKI resistance (95%, 19/20, risk ratio=2.53, 95% CI=1.50 to 4.29) was correlated with a higher detection rate of EGFR mutations, as previously reported (figures 1 and 2, table 2).
Detection rate and risk ratio by subgroup in patients without EGFR-TKI resistance
Even in 24 patients before EGFR-TKI therapy, individuals with advanced T stage (67%, 4/6, risk ratio=2.40, 95% CI 0.94 to 6.12), any lymph node metastases (54%, 7/13, risk ratio=2.96, 95% CI 0.77 to 11.43) or UICC stage IV disease (60%, 6/10, risk ratio=2.80, 95% CI 0.91 to 8.61), sensitive mutations were also more likely to be detected mutation but not significant (figure 2, table 2). The detection rate was notably higher in patients who developed extrathoracic disease progression (57%, 8/14, risk ratio=5.71, 95% CI 0.84 to 38.74) than in those who did not. Additionally, the adjusted risk ratio for mutation detection according to extrathoracic disease progression using the multivariate generalised linear model was 7.14 (95% CI 1.08 to 47.22, P=0.041) (table 3). There was a strong relationship between TKI-sensitive mutation detection and extrathoracic disease progression.
Tumour tissues from 12 of the 20 patients with TKI resistance were rebiopsied and subjected to genomic analysis (patients 1–10, 19 and 20). The results from 10 of these patients were concordant with those from cfDNA analysis (concordance rate, 0.83). While the results from rebiopsied tissue from the remaining two patients were positive for EGFR-TKI-sensitising and T790M mutations, one (patient 6) had a negative result by cfDNA analysis and the other (patient 19) was positive only in the EGFR-TKI-sensitising mutation test.
We evaluated the relationship between patient characteristics and the positive detection rate of EGFR mutations in cfDNA from patients with histologically confirmed EGFR mutations. TKI-sensitive mutations were detected in most (95%, 19/20) (figure 1) of the cfDNA samples obtained after confirming resistance. Notably, cfDNA obtained from patients who developed extrapleural tumours without EGFR-TKI resistance also exhibited high detection rates of the EGFR-TKI-sensitising mutation by cfDNA testing. This finding confirms the usefulness of examining cfDNA to deduce tumour burden and certain amounts of ctDNA in progressed cases, as suggested by previous studies.30 31 On the other hand, only a subset of cfDNA samples obtained before EGFR-TKI therapy was positive for TKI-sensitive mutations (38%, 9/24). One possible explanation for this difference is that the EMT of tumour cells, which often plays a role in resistance to EGFR-TKIs, permits tumour-initiating cells to invade blood vessels, which might increase the amount of plasma ctDNA by spreading tumour cells into the blood.32 33 A large cfDNA study found that the sensitivity of plasma genotyping for a known sensitising mutation was 82% from patients with acquired EGFR-TKI resistance.34 It is reassuring that the imperfect sensitivity of cfDNA analysis mitigates its value as a non-invasive alternative to a biopsy. Several systems have been approved as companion diagnostic systems for third-generation EGFR-TKI to detect EGFR T790M mutations from cfDNA all over the world.34 Given the wide range of reported sensitivities and specificities of the different platforms, it will be essential for prospective therapeutic trials to mandate the collection of plasma cfDNA to establish reproducible concordance rates with tissue for clinical validation.
Notably, our analysis found a lower risk of false-negative results and similar risk of extrapleural disease progression following previous therapy compared with prior studies that examined larger populations.22 35 Even in a smaller cohort such as ours, these analyses suggest the same trend towards reducing false-negative results. Therefore, selecting specific subgroups could increase the usefulness of cfDNA genotyping as a diagnostic test in response to individual preferences, to increase the true-positivity rate. This may be attributable to the increased use of next-generation sequencing for analysis, which can be used to analyse patient samples that cannot be genotyped because of insufficient tissue or tissue sampling errors related to tumour heterogeneity.36 To fully exploit the potential usefulness of next-generation sequencing of liquid biopsies, suitable patients must be selected for cfDNA analysis. Therefore, in order to validate the analysis results, we should select patients whose cfDNA contains a sufficient fraction of tumour DNA to screen mutations.
Limitations of this study include its small sample size. Additionally, not all individuals with a positive cfDNA result underwent a diagnostic rebiopsy; therefore, some mutations might have been clinical false-positives. Therefore, to validate the sensitivity, specificity and accuracy of cfDNA analysis, it is important to test and conduct standardised cfDNA-based large-scale studies with samples that contain certain amounts of ctDNA.
Analysis of cfDNA from patients with extrathoracic disease progression and acquired EGFR-TKI resistance may be efficient for clarifying the molecular mechanisms of resistance. Further analysis of cfDNA from patients with these features is required to validate tumour molecular profiling and treatment modification.
Supplementary data
Supplementary data
The thank all of the study participants and Dr Shin'ichi Yachida for his extensive assistance with the performance of the picoliter'ddPCR assay. They thank Dr Aya Kuchiba for valuable assistance with statistical analysis. The thank Libby Cone, MD, MA, from DMC Corp. (www.dmed.co.jp) for editing drafts of this manuscript. This research was presented at ESMO 2016 Congress (P1582) and abstracted in Annals of Oncology (2016) 27 (6): 545'551. 10.1093/annonc/mdw393.
Contributors YS and YF: conception and design. YO: administrative support. YG, HH, SK, HN and NY: provision of materials and patient samples. YS and KY: collection and assembly of data. YS, KY and TK: data analysis and interpretation. YS, YF and TK: manuscript writing. All authors: final approval of manuscript.
Funding The NCC Biobank is supported by the NCC Research and Development Fund of Japan. This work was supported in part by Grants-in-Aid from the Ministry of Health, Labor, and Welfare for Practical Research for Innovative Cancer Control (H26-practical-general-007/094) and by Management Expenses Grants from the Government to the National Cancer Center (23-A-18). The NCC Biobank is also supported by Management Expenses Grants from the Government to the National Cancer Center.
Competing interests None declared.
Ethics approval Institutional Review Board of the National Cancer Center, Japan.
Provenance and peer review Not commissioned; externally peer reviewed.
Correction notice The article has been corrected since it first published. The Abstract has been added in.
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Health has been a major concern over the past few years due to the sudden increase of lifestyle diseases. Illnesses such as heart disease, stroke, diabetes and metabolic syndrome have taken a toll on the lives of many individuals, particularly those who are working for long periods. Sitting down on office chairs all day can affect one's overall health.
At the same time, standing for long periods may also pose health threats to professionals, particularly those who stay in one position. Factory workers, nurses, security officers and salesladies suffer from leg, feet and back problems due to standing for extended periods.
Now, the development of ergonomic anti-fatigue mats could be the answer to this long-standing problem.
Reduces Fatigue And Tiredness
The body is not designed to stand for long periods. Standing for a long time on hard surfaces causes physical fatigue since the leg muscles become constricted. As a result, it reduces blood flow, causing discomfort and pain.
The heart will need to pump harder to make sure blood passes through the constricted areas, and this may lead to fatigue. Anti-fatigue mats reduce tiredness and promote good circulation in lower extremities.
Promotes Good Posture
Keeping proper posture is easier when you're standing up. A non-skid and comfortable anti-fatigue map helps maintain good posture. It evenly balances the weight on both the feet with firm support for the back and legs. As a result, there would be no pain and discomfort when standing, even for long periods.
Increases Productivity
With reduced discomfort and pain, there will be increased productivity. Employees will be able to focus on the work more because he or she is not feeling tired and pained.
Anti-fatigue mats are essential for those who stand for long periods. Manufacturers design these mats to provide comfort and, at the same time, remove tension from the body.


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Egg freezing lost "experimental" label but still not routine for all labsJanuary 12, 2013Carole No Comments »
You have probably heard by now that egg freezing is no longer defined as "experimental" by ASRM. What does this mean to patients? It means that the process of egg freezing, especially when vitrification is employed, can yield as good as fresh results. It does not mean that every lab can deliver those "good as fresh" results. It. Really. Does. Not. So when I heard that ASRM lifted the experimental label, I did not feel inclined to jump up and down with joy. Why not? Because once the "experimental" label is lifted, insurers can be pressured to pay for these reproductive services. Some labs will offer these services before they are expert and before they have a track record of good outcomes with this technology. When I heard the news, I felt inclined to duck to avoid being trampled by all the previously "slow to adopt new technology" labs rushing to provide egg freezing- pronto!- confusing "non-experimental" with "easy".
Buyer Beware of the new Egg Rush. I wrote a previous post on "Finding a good egg freezing clinic" which had among other bits of advice a list of questions (copied below) to ask before you turn over your precious eggs to a clinic.
How many women have cryopreserved oocytes with your facility?
Of this stored number, how many women have thawed all or some of their oocytes at your facility?
What is the survival rate of all the oocytes thawed at your facility? What is the probability that none of my eggs survive the thaw based on data from patients like me?
What is the fertilization rate of oocytes thawed at your facility and used for IVF?
What is the embryo development rate for thawed oocytes at your facility?
What is the live birth rate per oocyte thawed?
What is the live birth rate per embryo transferred. (Compare this to their live birth rate for fresh eggs).
When possible, ask about results for your age group. Know that the older you are, your chances are less that egg freezing will result in a live birth for you in the future. Some clinics refuse to freeze eggs for older patients (for example, 38 years or older) because the success rates are so low. Live birth rates from fresh eggs are also much less with advancing age so older age will reduce, sometimes dramatically, the success rate of any ART intervention. There are other questions that should be asked regarding cost of the freezing procedure, risks of the procedure etc. but as far as identifying the best lab for the procedure, the above list of questions speaks to the lab's experience and success with egg freezing.
When done expertly, there is no question that egg freezing is a real boon for women who are trying to preserve their fertility. However, as more labs offer egg freezing services, patients need to ask some tough questions of their clinic to get a better idea of how expert and experienced the lab is with egg freezing.
© 2013, Carole. All rights reserved.


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Item:Antique metal with turqouise necklace set
Necklace:18"-21" long
Pendant:3.5" long
Fishhook earrings total:1.6" long
Type: Jewelry Set
Theme: Beauty
Style: Vintage
Gender: Women's
Material: Alloy, Turquoise
Occasions: Banquet, Cocktail, Wedding, Party, Daily, etc
Features: Turquoise Inlaid, Hollow Base, Hook Earrings, Bridal Jewelry, Gift
Necklace Pendant Size: 3.5cm x 6.5cm/1.38" x 2.56" (Approx.)
Necklace Length: 48cm/18.90" (Approx.)
Earring Length:5cm/1.97" (Approx.)
Due to the light and screen setting difference, the item's color may be slightly different from the pictures.
Please allow slight dimension difference due to different manual measurement.
Package Includes:
1 x Necklace
1 Pair of Earrings


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Reference number: A3491219 Location: Argyll and Bute Are you enthusiastic about working with livestock, adaptable and prepared to contribute to the delivery of high quality stock on one of the best known livestock islands in … Read more
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Finding a featured image for your posts shouldn't have to be hard. Most people choose the most magnetic image in each post as the featured image. Featured Image Generator for WordPress can also help. It can search free photos from sites like unsplash and lets you import them with one click.
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Respirator for Spraypaint
Spray Paint respirators are designed to help protect against the harmful vapors caused by spray paint. These respirators are the most advanced replaceable cartridge respirators available. They are comfortable, low maintenance and simple to use. Soft, lightweight facepiece is extremely comfortable.
This respirator comes with a pair of cartridges.
Available in three different sizes for the perfect fit


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For my card I started with an Old Olive base which I then ran through the Big Shot and the new Framed Tulip embossing folder. I gave the piece a bit of a rub with shimmer paint. Then fast and easy I whipped up the rest of the card using the Ice Cream Parlor DSP and Quick Accents. The trick to Quick Accents is to layer them with Stampin' Dimensionals to give them a bit more interest.
Pop over to Create with Connie and Mary to see what the designers have made for this fun sketch using Sale-a-Bration goodies. By the way did you know that even though the Occasions Mini Subscription Series has already started, you can still see and access all the AMAZING projects and tutorials we have done so far and all the ones to come. They do NOT take the site down so you can always go back and access the site after the session has ended.
Stamps: Something to Celebrate (level 2 hostess)
Inks: Pacific Point Classic Ink Pad
Papers: Old Olive, Whisper White, & Daffodil Delight CS, Ice Cream Parlor DSP & Quick Accents
Accessories: Ice Cream Parlor Ribbon, Basic Rhinestones, 3/8" Daffodil Delight Ribbon, Dimensionals
Tools: Top Note Bigz L Die, Scallop Circle Punch, 1 3/4" Circle Punch, Modern Label Punch


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January 19, 2009Four years ago, I stood before you with a promise.
A promise that West Virginia would no longer stand still while the rest of the world raced by.
A promise that we would do away with the old divisions and begin a new kind of politics - with Democrats, Republicans and Independents, members of the Mountain Party and members of no party - all of us working together to build a New West Virginia.
A promise that our best days were still ahead of us, our greatest strengths still within us, and that, together, we could overcome any challenges we face to create a bright future for our children and grandchildren.
Four years later, I am honored and humbled to stand here once again as your governor.
We still have a long journey ahead of us, but we have already traveled a great distance.
And none of it would have been possible without you, the people of West Virginia. As I've always said, I believe in you more than you believe in yourselves.
I want to thank the thousands of state employees who get up every morning, eager to work hard to make life better for all of us in West Virginia. Thank you for your dedication and your service.
I want to thank all the public servants who serve our state with honor and pride, including our two distinguished U.S. Senators, Sen. Robert C. Byrd and Sen. Jay Rockefeller; our representatives in Washington, Congressman Nick Rahall, Congressman Alan Mollohan, and Congresswoman Shelley Moore Capito; the justices of our Supreme Court; members of our Board of Public Works; and all our legislators, especially President of the State Senate Earl Ray Tomblin and Speaker of the House of Delegates Rick Thompson.
I'd also like to take a moment to remember a dear friend we lost last year. Governor Cecil H. Underwood dedicated his life to serving the people of West Virginia. He led with fairness, courage, and deep pride in his home state. He will be missed, but never forgotten.
On a personal note, I wouldn't be here today without my tremendous staff and campaign volunteers. I am so grateful for your belief in me and your continued commitment to building a better West Virginia.
And I don't know where I'd be without my family. I am so blessed to have their love and their support. I want to thank my wonderful mother, Mary Manchin, my brothers and sisters, Janet, John, Paula and Rocky, my children Heather, Joseph and Brooke and my six wonderful grandchildren, Joey, Kelsey, Sophie, Chloe, Madeline and Jack.
And thank you to my incredible wife, the love of my life, my partner in everything, Gayle Manchin, who has served West Virginia with pride and grace as your first lady.
Today - as we celebrate the 80th birthday of Martin Luther King, Jr., and on the eve of the inauguration of our next president, Barack Obama - we are reminded that this is a country where the future is wide open - where anything is possible. And we are also reminded of our debt to those who came before us.
Three years ago today, two men died in the fire at the Aracoma Alma Mine. Just three weeks before that, 12 men died in the explosions at the Sago Mine. None of us will ever forget that terrible time. We mourned together, and then we stood, united together, and vowed to honor their memory by doing everything we could to eliminate mining deaths in every corner of our state. Today, we have made progress, but we still have more to do -- and we will not rest until we meet this sacred responsibility to our neighbors and fellow West Virginians and, most importantly, to the memory of those we lost.
I learned recently that the word "inauguration" comes from the Latin word "augur," meaning "omen." Apparently, before they installed their new leaders, the Romans would wait for good omens to appear. Only then would they venture into a new era.
Today, in West Virginia, we see good omens all around us. Signs of progress, signs of strength, and signs of new beginnings.
In the four years since I became your governor, an economic transformation has begun in West Virginia. We've created 23,000 new jobs and experienced the lowest unemployment in our history. Last summer, we led the nation in economic growth. Businesses have invested billions here in West Virginia. We've cut taxes on families, reformed government, strengthened our schools and health care, and improved services to all of our veterans and seniors.
It's true that there are new obstacles on the horizon. Our nation is facing the worst economic crisis since the Great Depression. We can see the effects everywhere - in grim balance sheets and falling home values, in our parents' shrinking retirement accounts and in the rising costs of just about everything. And our economists tell us it may get worse before it gets better.
We acknowledge these difficult facts; it would be foolish to deny them. But we are not discouraged by them. Four years ago, we set out on a long-term course for prosperity and growth. That journey may be rocky, but we're still on the right path.
And we can take confidence in our financial position. It is sound. Because of our fiscal discipline over the last four years, we are entering this period of uncertainty on more solid footing than many other states. Ten years ago, our unemployment rate was the highest in the country. Today, it is consistently better than the national average. And after three straight years of surpluses, our budget outlook is still strong.
We enter this new year with a clear view of the challenges ahead, a shared vision for our future, and confidence in the advantages we have earned, through our hard work and our sound planning.
Now, let us commit to continuing on the course we set four years ago. Let us commit to building a new West Virginia.
It is not enough to simply call something "new." We all know that. The river which cuts across half of our great state is the second-oldest river in the world and we still call it the New River.
A new West Virginia requires a renewed commitment.
So let us commit to creating and protecting more jobs, by attracting new employers to invest in West Virginia, helping our homegrown companies expand, and boosting our entrepreneurs.
Let us commit to seeking affordable, high-quality health care for every working West Virginian. This will make our workers more productive and our companies more competitive. But even more importantly, it will give hundreds of thousands of our neighbors better lives.
Let us commit to strengthening our education system. The jobs of the future will go not to the places with the richest land or most abundant resources, but the places with the richest minds. The only way our children will be able to compete and thrive in this global economy is if we give them a world-class education.
And let us commit to investing in the energy of the future. West Virginians know energy better than almost anyone. This has been our expertise for generations, and we can't let it go now. That means finding more efficient sources of energy. It means using natural gas, and renewable alternatives like wind, solar, hydro and biofuels.
And it means coal - coal that's safer than nuclear energy, cheaper than solar power and, unlike most of our oil, which comes from the Middle East, coal comes from right here in West Virginia.
We have the opportunity to use coal, through a much cleaner process, to help our nation become more secure through energy independence. And West Virginia has the researchers with the knowledge to make it happen. Because, our greatest resource isn't in our land, it's in our people.
If we tap that resource, the progress we have made will be just the beginning.
As your governor, I've had the chance to talk to people from every corner of the world about our state - the beauty of our mountains, the pride of our people, the strength of our ties to the land, to our history and, most importantly, to each other.
As a salesperson, I have the greatest job in the world - because I have the best product to sell: the State of West Virginia and our people.
We have reason to be proud of our past. West Virginia has an extraordinary story. And it still has lessons for us now, as we look forward to the years to come.
West Virginia has played a major role in making America strong. The coal that our ancestors mined far beneath these mountains fueled the Industrial Revolution. It stoked the steel factories that rose up all over America. The railroads that crisscrossed the nation the Navy ships that flew our colors during the world wars they were all powered by West Virginia coal.
And when it came time to go to war, it wasn't just West Virginia coal powering the armies of Democracy it was West Virginians themselves - serving and sacrificing in far greater percentages than many other states.
We made America strong and we kept America strong.
We did it before. We can do it again.
As I look into the future, I do see a New West Virginia. One that is, once again, a hub of global industry and trade.
I see a New West Virginia that once again draws people from around the world, not only for its natural beauty and strong communities, but also for its high-tech jobs, first-class schools and compassionate services.
I see a New West Virginia that once again leads an energy revolution that will keep this nation safe and bring unprecedented prosperity to our state and our country.
If we want to live and work and raise our families in a New West Virginia, then we must build it together.
That is the task we took up four years ago, and it is the task we rededicate ourselves to today.
With hard workers, strong families, strong communities, and the right investment - while others hunker down in the face of this economic storm we'll be prepared to take it head on.
And if we do that, we won't just be the envy of America we'll be a model for the entire world.
So once again West Virginians, let's do what we do best. Let's roll up our sleeves and let's get to work!
Thank you, God bless you, may God save the great state of West Virginia, and may God continue to bless the United States of America.
West Virginia's Governors
West Virginia History Center


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Central Council for Research in Ayurveda & Siddha (CCRAS)
The Central Council for Research in Ayurveda & Siddha (CCRAS) is an autonomous body of the department of AYUSH (Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homeopathy), Ministry of Health Family Welfare, Government of India. It is an apex body in India for the formulation, co-ordination, development and promotion of research on scientific lines in Ayurveda and Siddha systems of medicine and also the Sowa-Rigpa, commonly known as Tibetian or Amchi medicine.
Central Council for Research in Ayurvedic Sciences, Dept.of AYUSH invites applications for the following post for the Clinical Research Project entitled ''Tribal Health Care Research Project' of the Centre initially for a period of six months which may be curtailed or extended at the discretion of the competent authority and their engagement will be co-terminus with the Project. :
Senior Research Fellow (Ayurveda)
No. of Vacancies : 02 Post
Remuneration : Rs 20,000/- + HRA 30% p.m.
Qualifications : BAMS
Desirable : M.D/M.S (Ay), Computer Knowledge (MS Office)
Age limit : 35 years
Data Entry Operator
No. of Vacancies : 02 Posts
Remuneration Rs 13,000/- p.m. (Consolidated)
Qualifications : Bachelor Degree in any discipline from a recognized University. Diploma in Computer education from recognized institution. Should have good typing speed on computer and work experience
Age limit : 30 years
Multi Task Staff
No. of Vacancies : 02 Posts
Remuneration : Rs 10,000/- p.m. (Consolidated)
Qualifications : 10th Std (SSC)
Age limit : 30 years
How to apply:
Written test followed by interview for the following posts will be held on 02.12.2014 at 10.00 a.m. in the office of Research Officer Incharge Dr. A. Lakshmipathi Research Centre for Ayurveda, VHS Campus, Chennai-113. Applicants should bring their Bio-data along with original certificates, experience certificates etc. with a set of photo copies and two recent passport size photographs. TA/DA will be paid for attending the written test/interview
Advertisement Details & Application Form : http://www.ccras.nic.in/Advt/recruitment/alrca_chennai_21_11_2014.pdf
Similar Sarkari Naukri / Govt. Jobs 2019 Posts:
- Central Council of Indian Medicine (CCIM)
- North Eastern Institute of Ayurveda & Homoeopathy (NEIAH)
- Centre for Earth Science Studies (CESS)
- National Institute of Siddha (NIS)
- National Institute of Epidemiology (NIE)


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Extra Chapter for this week.
Shen Yanxiao was drinking tea, staring at Tang Nazhi.
There was something fishy! There was definitely something fishy!
She was also familiar with Tang Nazhi. This playboy did not seem to think too much of the game. So even if he lost, he would never be this depressed.
It seemed that the problem did not lie on the outcome of the match.
Was it because of his opponent in the match?
"You know that person called Li Xiaowei." Shen Yanxiao unhurriedly opened her mouth. It was not an interrogative sentence, but rather a statement.
Tang Nazhi immediately sat up straight, his face turned serious as he said, "How can I possibly know that guy! I don't know him! I never know him!"
"Oh, then forget what I just said. I would have liked it if you are acquainted with him, in that way, I would be polite to him in the afternoon match. But since you don't know the guy, then that's also not a problem. I've got a couple of curse techniques on my hands and has been looking for someone to test them out in this tournament. Fortunately, I'm good enough not to experiment on you guys. So I might as well use him well." Shen Yanxiao had a clear look on her face as she spoke.
Tang Nazhi's expression immediately changed upon hearing her words.
"Don't! Don't do that!"
Shen Yanxiao raised an eyebrow.
"I don't know what are you so anxious about, or have you changed your hobby now. You don't love beautiful women anymore?"
Tang Nazhi almost choked and died by Shen Yanxiao's remarks.
But whenever he thought that Shen Yanxiao was likely to use some inhuman curse techniques on Li Xiaowei in this afternoon match, he could not help but break into a cold sweat.
"Don't worry, as your companion, I will take revenge for you. He shot you into a hedgehog. I will pull him into my range and turn him into a hedgehog as well, furthermore, he will have more thorns than you." Shen Yanxiao resentfully said, looking like she was really determined to settle an old score and avenge Tang Nazhi.
Tang Nazhi looked at Shen Yanxiao with an expression of wanting to cry, but tears would not come out.
Before, because Shangguan Xiao, Pu Lisi, and Luo Fan forced him to leave the Pharmaceutical Branch, despite the fact that she was faced with two enemies, Shen Yanxiao still turned Shangguan Xiao and Luo Fan into a complete waste.
Now, Tang Nazhi did not doubt the authenticity of Shen Yanxiao's words of vengeance in the least.
He was very touched last time, but...
This time was different!!!
"Little Xiao! Calm down!" Tang Nazhi gazed at Shen Yanxiao with an almost crying face. He was really afraid that because of this little girl's fury which made her hair stand on end, she would shoot Li Xiaowei to the point he would resemble a honeycomb. He would really go crazy then.
"Nazhi, is it not good for me to avenge you? In any case, you don't know that guy, so just leave it to me. I'll definitely make him look good." Shen Yanxiao raised the banner of revenge for her companions full of justice.
"I understand! I understand!! Don't ah! You must not make him look good! He's already very ugly!" In his panic, Tang Nazhi uttered some illogical words.
After he finished speaking, he immediately realized what he had said and his expression became stiff.
Shen Yanxiao's mouth revealed a "sure enough" smile.
"Ah, you and your repressed IQ." Qi Xia heaved a deep sigh while looking at Tang Nazhi who had completely been led by the nose by Shen Yanxiao.
"Spill it. In the end, what is the matter." Throwing away the mask of a good sister, Shen Yanxiao overlapped her legs, folded her arms, and calmly looked at the stupefied Tang Nazhi.
Tang Nazhi wanted to cry, but the words he uttered just now was like a spilled water that was obviously impossible to get back.And chat with us in or in .


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The validity of the SmartCEMS® PEMS model is entirely dependent on the training dataset and the quality assurance program in place at the site. If a comprehensive model is developed initially, there would be no reason to limit the range of time that it would be valid. An initial model that includes all normal operations, startups, shutdowns, and transitional operating states is deemed 'robust' and will provide valid predictions for compliance purpose for many years. The model can easily be retrained if required for any extreme ambient or other operating conditions not encountered during the initial training data collection. The system keeps track of when the model is valid for a given set of process data in real-time and provides alarms for tracking excursions from the established model envelope and records the status of the model prediction automatically.
Requirements for a periodic or annual recertification test would be dependent on the local regulatory requirements and the facility quality assurance program. We would recommend retraining the PEMS model (and recertification if required) following any major process change or the addition of pollution controls or for changes in fuel and fuel quality. Validation of the PEMS model can be conducted following tuning or annual maintenance activities (such as a extensive overhaul), but this would not be mandatory. The PEMS can be retuned at any time (periodically or continuously) using existing CEMS equipment or by mobilizing temporary or mobile emission monitoring equipment and collecting the process data concurrently with the target pollutant emission rates.


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Active Plumbing is the name you can trust near you for all your gas fitting needs. Plumbers who are also licensed gasfitters surround our business. If plumbing and gas are the words in your mind, it does not matter what time or day or night since we are always ready to serve you. You should call us now or use our online booking form to get a licensed gasfitter within the next hour. Our friendly, highly skilled plumbers can tackle any plumbing and gas-related jobs.
Gas Fitting Services
Gas installations and fittings, as well as gas leak repair, should be done by professional licensed gasfitters as they are potentially dangerous jobs and services. Our licensed plumbing and gas team of professionals are highly experienced and well trained. We can guarantee you that our job will be completed according to schedule. To ensure we can repair or replace on the spot, we carry most components in our service vehicles. Whether you need a repair or installation of your gas appliances, call Active Plumbing today so that we can discuss your needs.
Gas Hot Water Plumbing
Looking for new installation of gas hot water? Or wanting to change from electric to hot gas water? We can help you decide if a gas hot water system is the right thing for you. A gas hot water system is more cost-effective than an electric system, and you can have hot water on demand. It means that you only use what you need and it does not run out. If you are living in a house with a lot of people or there's a minimal need for hot water in your home, then a gas hot water system is a perfect investment for you.
Gas Oven Plumbing
Gas ovens are widely used as they cook faster, better for the environment and most of all cheaper to run. Most professional chefs love gas ovens as the food does not dry out as much. Gas ovens are perfect for slow cooked meals and roasts. Installing a gas oven can improve your cooking and also minimise running costs. We install, gas ovens. Call Active Plumbing now to talk about your gas oven needs.
Gas Leak Plumbing
Gas leaks should be dealt with immediately as they can be very dangerous. For a fast emergency response, call Active Plumbing, n 1300651965 and we will have a licensed gasfitter on their way. We can help you what the right thing to do over the phone to keep you calm and safe while our gasfitter is on the way. Our plumbers are equipped, track gas leaks. We will not leave your premises until all work is double checked, offering you added peace of mind.
Suburbs we service:
Inner suburbs
Albion, Alderley, Ascot, Aspley, Bald Hills, Banyo, Boondall, Bracken Ridge, Bridgeman Downs, Brighton, Brisbane Airport, Carseldine, Chermside, Chermside West, Clayfield, Deagon, Eagle Farm, Everton Park, Fitzgibbon, Gaythorne, Geebung, Gordon Park, Grange, Hamilton, Hendra, Kedron, Keperra, Lutwyche, McDowall, Mitchelton, Myrtletown, Newmarket, Northgate, Nudgee, Nudgee Beach, Nundah, Pinkenba, Sandgate, Shorncliffe, Stafford, Stafford Heights, Taigum, Virginia, Wavell Heights, Wilston, Windsor, Wooloowin, Zillmere


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We are pleased to be joining 15 rehearsal spaces which have been created in urban and rural areas throughout England. Working with UK Music gives us access to music industry contacts and information.
UK Music is an industry-funded body established in October 2008 to represent the collective interests of the recorded, published and live arms of the British music industry. Through collective representation UK Music promotes the interests of record labels and music publishers (major and independent), songwriters, composers, lyricists, musicians, managers, producers, promoters, venues and collection societies. UK Music exists to guide policy makers towards decision-making in the best interests of our sector and the best collective interests of our membership, now and for the future. UK Music represents and promotes the interests of every part of the British music industry


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/ John Blenkiron and Sons Funeral Directors
John Blenkiron and Sons Funeral Directors
Owning Company: Funeral Partners Ltd
We are a funeral director in Barnard Castle , United Kingdom dedicated to helping your family when in need. For more information please contact us.
Simple Funerals
For clients requiring a simple funeral with minimal professional services and limited options. The simple funeral will be provided and the hearse will take the deceased to the nearest cemetery or crematorium.
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This option allows you to personalise the funeral and add additional items. Your funeral director can offer advice and guidance.
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Our Address
19 Galgate
Barnard Castle
2 months ago
Nothing but praise for the service you provided on the loss of my loved one.There was care and compassion shown to myself and family. Nothing was a problem to them from start to finish Thank you all so much
c little via Google
8 months ago
Our funeral director Carl Tate from Blenkiron & Sons could not have been more helpful. He supported my brothers and me in our wish to personalise our service at Darlington Crematorium; Carl and his team showed huge respect and dignity throughout the whole process from the first visit, to the day of the funeral itself and then sorting details a...
Jill Cole via Google
a year ago
Very professional and caring company. Genuine and helpful. Helped us wonderfully during a very sad time.
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a year ago
Thanks to all the staff for their care and professionalism. They made such a difficult time that little bit easier. My respects.
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