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Invensis Learning's ITIL Intermediate Service Operation Training Course in Frankfurt is delivered by highly qualified trainers with extensive IT Service Management experience. This AXELOS's ITIL Service Operation Certification is one of the most industry-recognized certifications for IT professionals globally. This ITIL SO Certification Course in Frankfurt is ideal for individuals and enterprises that are looking to gain an in-depth understanding of principles, operational activities, functions, and processes that help organizations and individuals to manage the products and services of an organization.
The main takeaways from this ITIL SO Certification course in Frankfurt are that you demonstrate a comprehensive understanding of how to coordinate and execute activities that managing the products or services developed during Service Strategy, design, and transition phases of the IT service lifecycle. Participants will receive course completion certificate.
We deliver ITIL Intermediate Service Operation Training in Frankfurt through classroom and live online virtual modes. Enroll now and gain this ITIL Service Operation certification in Frankfurt today.
|Training Modes
- Instructor-led Classroom Training ( Request for Training )
- Instructor-led Online Training ( Request for Training )
- On-site Group Training ( Request for More Information )
- Focused 1-to-1 Training
|Areas of Study
- Service management as a practice concept and service operation principles, purpose, and objectives
- How processes in ITIL Service Operation interact with other service lifecycle processes
- Roles and responsibilities within ITIL service operation to achieve operational excellence
- Measuring ITIL Service Operation, and more
|IITIL Service Operation Training
|Request for the ITIL Service Operation training in Frankfurt
|ITIL Service Operation Course Duration
|ITIL Service Operation Course Syllabus
|ITIL Service Operation Certification Eligibility Criteria
|ITIL Service Operation Exam Format
|ITIL Service Operation Exam Fees
The ITIL Service Operation examination cost in Germany is USD 330.
|Who Should Attend ITIL Service Operation Certification Training
Job roles that can benefit from ITIL Service Operation training course in Frankfurt include, but are not limited to
This module focuses on the purpose, objective, scope, and value to the business of service operation, the context of service operation and service lifecycle, and the service operation fundamentals.
This chapter focuses on service operation principles such as: achieving balance in service operation; providing good service; involvement in other lifecycle stages; operational health; communication; documentation; service operation inputs and outputs.
In this module participants will learn about the purpose, objectives, scope, and value to the business of each process, policies, principles and basic concepts, process activities, methods and techniques, triggers, inputs, outputs, and interfaces, and CSFs and KPIs.
This module focuses on some of the common service operation activities such as IT operations, monitoring and control, server and mainframe management and support, network management, storage and archive, database administration, middleware management, data center management, operational activities of processes covered in other lifecycle stages.
This chapter focuses on understanding functions, service desk function, technical management, and application management function, and service operation organizational structures.
In this module, participants will learn about generic requirements, event management, incident management, request fulfillment, problem management, access management, service desk.
This module focuses on managing change in a service operation, service operation and project management, assessing and managing risk in service operation phase, operational staff in design and transition, and planning and implementing service management technologies.
This chapter focuses on challenges, critical success factors, and risks in service operation phase of the service lifecycle.
The daily agenda of the 2-day ITIL SO Training is detailed below:
At Invensis, we provide ITIL SO training in Frankfurt in three different learning modes in instructor-led classroom training, instructor-led online training, and on-site group training.
You will achieve 3 credits for this ITIL SO training which you can use in your journey to becoming an ITIL Expert.
Yes, the examination fee is included in the course fee.
The ITIL Service Operation credential does not have an expiry period,and the certification is valid for life.
Yes, Invensis Learning is a PEOPLECERT Accredited Training Organization (A.T.O) for providing ITIL Service Operation training course worldwide.
AXELOS is the governing body for all of the ITIL training programs. Invensis Learning is an AXELOS Certified Partner for imparting ITIL Foundation, ITIL Intermediate modules, and ITIL MALC Training courses worldwide.
Individuals and Enterprises can make payment for the training through 2 different modes such as –
For more information on payment details, please contact us at firstname.lastname@example.com
You can call us, leave your query on Live Chat for instant support, or Request a Call Back to have your query resolved.
Frankfurt, officially known as Frankfurt am Main is one of the largest cities in Germany with a population of over 2.3 million people. It is classified as an alpha world city and is a major hub for commerce, culture, tourism, and education. Frankfurt is a very ethnically diverse city with immigrants and expatriates from all over the world working here. The Frankfurt Airport is one of the busiest in the world and serves as a major connectivity node in Europe.
Frankfurt is a leading financial in the world and is home to the headquarters of major financial institutions such as European Central Bank, German Federal Bank, and Frankfurt Stock Exchange. The economy of Frankfurt is driven by the accountancy, financial services, consultancies, manufacturing and real estate. Frankfurt's €172 billion GDP contributes significantly to Germany's economy. The largest employers in Frankfurt are Deutsche Bank, PwC, EY, Commerzbank, Accenture, KPMG, Crytek, and Lufthansa.
The highest average salary in Frankfurt for professionals in Project Management is €91,167, ITSM is €108,612, and Quality Management is €103,027. Whereas a senior project manager with PMP certification the salary goes up to €114,645, with ITIL certification it goes up to €127,217, and with Six Sigma certification, it goes up to €125,076.
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Petite student had a threesome sex with an old professor
Two student entered a cabined of a mature professor and proposed him to pass their exam with a threesome sex. Slutty girls stood on their knees in front of an old man and began to polish his big dick with their tongues. Then one blonde laid down on the table and got in her vagina his long penis. While the lover was fucking a fair-haired babe in a missionary position, she licked the pussy of her skinny friend.
16 Sep 2018
(1 comment)
8 months ago

subset: commoncrawl


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Figures from the Financial Ombusman Service released recently confirmed that, in the last year alone, there were than 104,000 complaints to the financial Ombudsman about PPI (payment protection insurance).
The complaints are not unexpected, with consumers now being made more widely aware of their potential right to make PPI claims.
PPI claims can be made by those who were mis-sold the PPI policies in recent years. This mis-selling was widespread, often deliberate and undoubtedly at huge financial cost to consumers.
At Moneybright, we can help you to make PPI claims. If you're not sure whether you could be eligible, get in touch today and find out how we could help.


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President Barack Obama and Chancellor Angela Merkel recently tried on VR headsets just for the heck of it.
President Obama is the leader of the United States of America and he has surveillance and national security at the top of his agenda. Yet he and Angela Merkel, the head of Germany tried on a different version of reality recently than the ordinary everyday realpolitik that goes on around the world.
Obama and Merkel underwent the VR experience at a fair in Hanover, Germany. Obama is reported to have said upon entering the wonderful simulated environment of VR that it was a "brave new world".
This takes its reference from Aldous Huxley's novel of the same name about a dictatorial state in the future where people will depend for their happiness on the illusory pleasures of drugs and sex.
What Obama and Merkel tried on were the world's smallest 3D camera systems. This depth-plumbing camera allowed POTUS Obama to extend his hands and feel the VR environment like it was an actual and tangible form of reality. It was a source of pride for the mother company to see the president of the free world take the device for a test-drive.
The occasion was a chill-out time with his frenemy Angela Merkel. While from the external situation it looked like both Obama and Merkel had googly-eyed boxes fixed to their faces, what everyone was curious about was what they saw inside those boxes.
Virtual reality: President Barack Obama and Chancellor Angela Merkel sample the latest tech in Hanover pic.twitter.com/E0ftcvnIjf— AFP news agency (@AFP) April 25, 2016
The way Obama acted with the VR headset made him look like a participant in a Hamlet reenactment. Merkel though looked radically different in her pose. While here both leaders looked to be in synch, later on they revealed their real intentions via their individual body language.
Merkel looked standoffish and Obama appeared to be morose. They often had their arms crossed in a defensive posture and both seemed to give each other glum and bitter glances.
It was as if Angela seemed to be saying to Barack that "your security and surveillance society is ruining the lives of so many innocent people around the world". Obama seemed to be ignoring her for all purposes though.
The two world leaders don't see eye to eye. They have their differences and are not exactly in each other's good books. Yet they belong to the same movement known as Western Civilization and so they tend to cooperate (although it is a superficial affair).


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25 Moments That Basically Sum Up Your Sale Artist Experience | sale artist
A Revolution-era oil painting will accompany added 18th-century American works at the St. Louis Art Museum, allotment of a arguable auction by a Massachusetts museum.
Benjamin West's 1775 painting was awash to advice pay for aliment at the Berkshire Building in Pittsfield afterwards months of criticism and alike a accusation that approved to stop the sale.
Sold to St. Louis for $350,000, the 6-foot-wide "Daniel Interpreting to Belshazzar the Handwriting on the Wall" is a "terrific acquisition," building babysitter Brent Benjamin said Thursday.
PITTSFIELD, Mass. • The Massachusetts building that drew all-embracing accusation for its accommodation to accession money by affairs dozens of works o…
"We never anticipation we'd see it on the market."
Calling West the "father of American painting," Benjamin said the artist's accountable is religious but additionally seems to accept political undertones.
It may accept been a "quiet bulletin to George III to get his act together." Of advance the baron never did aim for a peaceful way to accomplish nice with affronted American colonialists.
Benjamin presented the painting forth with acquisitions of a admirable account by 18th-century artisan Angelica Kauffman and a accumulating of prints by and afterwards Hieronymus Bosch and Pieter Bruegel. He additionally previewed for journalists the art museum's accessible exhibitions.
One of the big shows planned will be "Paul Gauguin: The Art of Invention," which opens July 21.
With added than 50 works on accommodation from Copenhagen's Ny Carlsberg Glyptotek, the exhibition will accommodate both the French artist's acclaimed works from his time in Tahiti forth with aboriginal Impressionist paintings. Interestingly, a Gauguin-illustrated album donated by amateur and St. Louisan Vincent Price is included.
Earlier in the year will be a huge affectation of sculptures by Rachel Whitehead (who casts things both ample and small, such as the central of a garden afford or the base of a chair). The assignment by the British artisan goes on appearance March 17.
Next abatement will affection "Dutch Painting in the Age of Rembrandt," which opens Oct. 20. The works appear from the Building of Fine Arts, Boston.
A western acquaintance of that celebrated Boston institution, the Berkshire Building has aloft about $54 actor by affairs 22 of its works, including two by Norman Rockwell, who lived for abounding years adjacent in Stockbridge, Mass.
The museum's best admired painting sold, Rockwell's "Shuffleton's Barbershop," was admired at amid $20 actor and $30 million. It was purchased for an bearding sum by the Lucas Building of Narrative Art in Los Angeles.
Selling art to pay for building budget or to addition an award violates the belief of the American Alliance of Museums. The Association of Art Building Directors accustomed the Berkshire in May, allurement associates not to accommodate works to it. Several Massachusetts residents, including a grandson of Rockwell, had filed lawsuits aggravating to anticipate the sale. Those apparel were unsuccessful.
But the museum's arguable accomplishments were a gift, of sorts, for the St. Louis Art Museum, which had approved to ample a gap in its American collection. Another bright-side appearance of the auction is that the Rockwell and West paintings, forth with a few others that accept been disclosed, are activity to accessible museums instead of clandestine collectors.
The Benjamin West painting won't be on display, though, until backward abutting year. It needs some charwoman (on Thursday, the assignment seemed to affectation the outline of a baby handprint). Given to the Berkshire in 1909 by Zenas Crane, it is the oldest painting the building sold. Crane, a cardboard magnate, was one of the museum's founders.
Even admitting the painting will accompany its American aggregation here, the assignment was fabricated in Britain. West was a admired of Baron George III, who appointed him actual painter to the cloister in 1772. Although built-in in Pennsylvania, West catholic to Italy and again England, area he would serve as the additional admiral of the Royal Academy. He never alternate to America.
There's no accounting evidence, no "smoking gun," that proves West's painting of the "handwriting on the wall" was a bulletin to Baron George, says Amy Torbert, the St. Louis museum's abettor babysitter of American art. But she is assured that the museum's new accretion independent a bulletin above its biblical story.
Go! Magazine's go-to adviser for the weekend's best ball in and about the Lou, delivered account to your inbox.
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January 2013 Bulletin: Item 2
'Inside ReNLA'
a. Committee members
During 2012 the committee has been expanded with a view to increasing involvement by members in the running of the Research Network and enhancing sustainability of ReNLA activities into the future. There are fifteen members on the new committee, and they come from or are based in Austria, Brazil, Cameroon, China (including Hong Kong), India, Ireland, Japan, New Zealand, Poland, Turkey and the UK. See https://ailarenla.org/committee/ for a full list of roles. Here we present profiles of the individual committee members in alphabetical order of surname:
Naoko Aoki teaches Japanese as a second language pedagogy at Osaka University, Japan, and has written mostly but not exclusively about teacher autonomy, which has led her to explore narrative mode of research. She's been a convenor of the ReNLA since 2011 and is in charge of the research agenda and the beginner resources projects.
Vasumathi Badrinathan heads the Department of French of Ramnarain Ruia College, Mumbai, India and is also professor and teacher trainer at the Alliance Française de Bombay. She holds a doctorate in didactics of foreign language teaching from the University of Charles de Gaulle, Lille 3, France. Her research interests revolve around learner and teacher autonomy, the non native/native teacher question in foreign language teaching, intercultural approach and use of technology in the teaching-learning process. She is a member-at-large on the ReNLA committee.
Mehmet Boyno joined and organised several autonomy related events after being introduced to learner autonomy during his PhD studies in 2006. He is determined to raise awareness concerning learner autonomy in Turkey through many more events and training programmes for teachers and students. He is also responsible for 'Events' on the ReNLA committee.
Lorna Carson is Assistant Professor in Applied Linguistics at Trinity College Dublin, where much of her teaching and research focus on autonomy in language curricula and assessment. On the ReNLA committee, she looks after the area described as 'members' publications', which involves both collecting bibliographic details of recent work and engaging with authors to help disseminate and cast light on the research process. If you would like to participate in an interview about a forthcoming article or book, please contact her.
Alice Chik is currently working as an Assistant Professor at the Department of English, City University of Hong Kong. Alice's main research areas include narrative research, new media and popular culture in second language education. She is a Joint Convenor of the ReNLA and is also in charge of membership, one of the research agenda topics, and web interactivity.
Lucy Cooker is a Lecturer in Education at the University of Nottingham, where she coordinates the South East Asia cohorts of the PGCE (International). Her research interests include language learner autonomy, self-access language learning, alternative assessment, materials development, teaching methodologies, language learner identities, and the use of Q methodology. Her PhD thesis was on the formative assessment of language learner autonomy. Lucy has been an active member of the AILA Research Network on Learner Autonomy for the past ten years. She is currently co-editor of Learner Autonomy in Language Learning (https://ailarenla.org/lall/) with Richard Smith and Mirosław Pawlak, and has also taken on administration of the AUTO-L discussion list.
Kerstin Dofs is the Manager of the Language Self Access Centre (LSAC) at Christchurch Polytechnic Institute of Technology (CPIT) in Christchurch, New Zealand. She has a Masters of Arts in Language Learning and Technology through the University of Hull, UK. Her research interest lies in Autonomous Language Learning (ALL), especially around learner and teacher support for ALL. In the ReAILA committee She is working together with Naoko Aoko and Sarah Mercer on mapping out and suggesting resources for new and beginner researchers in the field of Autonomous Learning.
Harry Kuchah Kuchah is currently Teaching Fellow in Applied Linguistics in the School of English, University of Sheffield. Previously he worked as teacher trainer and pedagogic inspector in Cameroon and also as senior teaching fellow at the University of Warwick, UK. He serves on the ReNLA committee as Bulletin co-editor with Richard Smith.
Sarah Mercer works at the University of Graz in Austria, where she has been teaching since 1998. At present she is Head of the Doctoral Programme for 'Language Teaching Methodology and Second Language Learning'. She also works as Deputy Head of the Centre for Teaching and Learning in the Humanities. Her research interests involve all aspects of language learner psychology, in particular self beliefs and learner agency. She has recently joined the ReNLA committee and is helping Naoko and Kerstin compile a list of resources for early stage researchers interested in the field.
Jo Mynard is an Associate Professor at Kanda University of International Studies in Japan. She is the Director of the Self-Access learning Centre and Assistant Director of the English Language Institute. She became interested in learner autonomy in 1996 while studying at Trinity College, Dublin. She worked part time in the self-access centre when studying for her M.Phil in Applied Linguistics there. She has worked in Spain, the UAE, Ireland, the UK and Japan and has a Doctorate in Education (TEFL) from the University of Exeter (UK). She has been a member of the RenLA committee since 2008 and manages the website.
Peter Jing HUANG is an Assistant Professor in the Department of Education Studies at Hong Kong Baptist University. His research interests include autonomy in language education, teacher education and development, and second language learner identity. On the ReNLA Committee he has been working with Richard Smith and Nana Long to introduce recently completed doctoral work on autonomy to the research community.
Nana Long is currently a committee member of AILA ReNLA working on seeking and organizing doctoral theses together with Peter Jing Huang and Richard Smith. She writes: "It's a good opportunity for me to know so much great research on different topics of learner autonomy. I am happy to share these precious recourses with all researchers and practitioners interested in learner autonomy. Besides, I am now doing my own PhD study on EFL teachers' autonomy in the Chinese tertiary context."
Mirosław Pawlak, who is co-editing Learner Autonomy in Language Learning (https://ailarenla.org/lall/) with Lucy Cooker and Richard Smith, is Professor of English in the Department of English Studies at the Faculty of Pedagogy and Fine Arts of Adam Mickiewicz University in Kalisz, Poland and the Institute of Modern Languages of State School of Higher Professional Education, Konin, Poland. His main areas of interest are SLA theory and research, form-focused instruction, corrective feedback, classroom discourse, learner autonomy, communication and learning strategies, individual learner differences and pronunciation teaching.
Liliane Sade (no photograph available) is a member-at-large on the ReNLA committee. She received her PhD from the Federal University of Minas Gerais, Brazil. She is Associate Professor of English and Applied Linguistics in the Department of Languages, Arts and Culture at the Federal University of São João del-Rei, Brazil, where she is also the Dean of International Relations. Her research interests centre on the interface between complexity theory, identity issues and second language learning, as well as discourse analysis and narrative research.
Richard Smith is an Associate Professor in the Centre for Applied Linguistics, University of Warwick. He is in his second term as a convenor of the Research Network, having served from 2008-11 and been re-elected for 2011-14. He is also LALL and e-bulletin co-editor, and has been contributing to the doctoral theses project. He is interested in support for autonomy-oriented pedagogy, teacher-learner autonomy and research engagement by teachers.
b. Longevity of ReNs, and future of ReNLA
In our last but one Bulletin (July 2011), a campaign was announced to persuade AILA to drop the restriction in its bylaws that 'The life of a ReN is not expected to be longer than six years' (see https://ailarenla.org/bulletins/july2011item3/) . This was important as the Research Network on Learner Autonomy was at that point coming up to the end of its sixth year of existence (though it had existed for many years before that as a Scientific Commission). In our last Bulletin (February 2012), we were pleased to inform members that:
Just prior to the [August 2011] AILA Congress, the 'governing body' of AILA had an hour-long discussion of issues pertaining to Research Networks such as ours, and decided that there should no longer be a limit of six years on their lifetime. We can therefore continue to apply to AILA every three years for renewal.
This was reported in good faith, on the basis of an email message (dated 25 August 2011) from the then-President of AILA, part of which read as follows:
The meeting decided (and worth remembering that EBIC meetings have a binding decision-making role, unlike EB meetings) that the relevant clauses should be amended to enable all ReNs to renew their status every three years, without time limit, provided they meet the necessary criteria for renewal.
In the meantime, we had applied for renewal for 2011-14 following procedures laid down in the AILA bylaws (http://www.aila.info/about/statutes-and-bylaws/bylaws.html#art7) and our application had been accepted (we will need to apply for renewal again in 2014, 2017 etc.)
However, despite repeated requests from us during late 2011 and 2012 for the bylaw as stated on the AILA website to be actually changed to reflect the decision of AILA's governing body to remove the restriction on lifetime of Research Networks, this has still not occurred. All that has happened is that 'The life of a ReN is not expected to be longer than six years' has been changed to 'The life of a ReN is not generally expected to be longer than six years' (i.e. insertion of 'generally').
We are now seeking opinions of members as to what our next steps should be. Please contact the convenors directly or express your thoughts / ask questions on AUTO-L.
(Richard Smith)
c. Publication of AILA 2011 papers
Papers given at the AILA 2011 ReNLA Symposium, along with some given at the Canterbury 'Cutting Edges' conference supported by ReNLA, also in 2011, are currently being edited by Garold Murray and Richard Smith for publication in a Palgrave Macmillan book, Social Dimensions of Learner Autonomy, due to appear at the end of 2013.


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Gigantism and acromegaly are both conditions that are brought about by an overproduction of growth hormone resulting in excessive growth which is almost always due to a benign pituitary adenoma or tumor. This excessive growth condition is called gigantism when the condition occurs during childhood while it is called acromegaly when the condition occurs during adulthood.
Gigantism is the abnormally high linear growth caused by the excessive action of insulin growth factor 1 (IGF-1) while the epiphyses are open during childhood. Acromegaly is the abnormally high linear growth also caused by the excessive action of IGF-1 that occurs after the epiphyseal growth plate closes in adulthood.
The anterior lobe of the pituitary gland is the one responsible for producing growth hormones. The growth hormone triggers the growth of muscles, bones, and other internal organs. An excessive growth hormone results in an abnormally booming growth of these tissues. Aside from a noncancerous pituitary tumor that usually causes the overproduction of the growth hormone, there are also certain rare lung and pancreas tumors that have the ability to produce hormones that trigger the pituitary gland to produce excessive amounts of growth hormone.
Other Causes
- Neurofibromatosis
- Carney complex
- Multiple endocrine neoplasia types 1 (MEN-1)
- McCune-Albright syndrome (MAS)
Symptoms of Gigantism
The onset of the symptoms of gigantism is usually dramatic. These are the following symptoms of gigantism:
- Tall stature
- Enormous growth of long bones
- Lengthening of the arms and legs
- Mild to moderate obesity
- Headaches
- Larger head circumference of more than 2 standard deviations above the mean value for a specific gender or age also known as macrocephaly
- Soft-tissue swelling
- Soft tissue hypertrophy
- Enlarged peripheral nerves
- Visual changes
- Pituitary insufficiency or hypopituitarism where the pituitary gland does not produce enough of certain hormones or fails to produce one or more of its hormones
- Exaggerated growth of the hands with thick fingers
- Exaggerated growth of the feet with thick toes
- Rough facial features
- Frontal bossing – a prominent protruding forehead which can be associated with a heavier brow ridge
- Excessive sweating or hyperhidrosis
- Prognathism – protrusion of the upper jaw (maxilla) or lower jaw (mandible) beyond a predetermined imaginary line in the coronal plane of the skull
- Delayed puberty
- Hypogonadotropic hypogonadism – diminished functional activity of the reproductive glands that can cause a decline in sex hormone biosynthesis or an interrupted stage of puberty
- Peripheral neuropathies such as carpal tunnel syndrome
- Eunuchoid habitus – a body habitus that is tall, underweight, and slim with long arms and long legs
- Cardiovascular disease
- Osteoarthritis
- Endocrinopathies or hormonal problems
- Benign tumors
Symptoms of Acromegaly
The onset of the symptoms of acromegaly in adults is usually subtle. These are the following symptoms of acromegaly:
- Coarsening of facial features
- Doughy-feeling skin over the face and extremities
- Soft-tissue swelling of the feet and hands
- Noticeably large pores
- Thickening and darkening of the skin
- Headaches
- Nasal bone hypertrophy
- Enlargement of the lower lip
- Enlarged and furrowed tongue
- Deepening of the creases on the nasolabial folds and forehead
- Increase in coarse body hair
- Hard and thick nails
- Thick and edematous eyelids
- Oily skin
- Wide spacing of the teeth
- Frontal Bossing
- High blood pressure
- Increase in the size and function of the sweat and sebaceous glands
- Excessive apocrine and eccrine sweating
- Offensive body odor
- Cartilaginous proliferation of the larynx that causes the patient to have a deep husky voice
- Prognathism
- Excessive hair growth all over the body or hypertrichosis
- Peripheral neuropathies
- Sleep apnea
- Cutis verticis gyrata – excessive formation of scalp skin that creates deep folds on the scalp
- Mitral valvular regurgitation – a condition where the heart's mitral valve does not close tightly letting blood leak backward into the heart interrupting the flow of the blood to the rest of the body or through the heart
- Milky nipple discharge or galactorrhea in women
- Shrinking of the breasts in women
- Mild hirsutism, a condition of male-pattern hair growth in women
- Costal cartilage growth that results in a barrel chest
- Articular cartilaginous proliferation
- Impaired glucose tolerance in 50% of patients
- Hyperpigmentation in 40% of patients
- Cardiac disease in 30% of patients
- Diabetes mellitus in 10% of patients
Gigantism and acromegaly can be diagnosed through the following procedures:
- Blood tests confirm the diagnosis of both conditions when they show high levels of the growth hormone and insulin-like growth factor 1 (IGF-1).
- Oral glucose tolerance test is performed by giving the patient a glucose drink to suppress the growth hormone levels and show that normal suppression doesn't occur.
- MRI or CT Scan is done to detect abnormal growths in the pituitary gland. MRI can show images of pituitary adenomas while CT scan can show ovarian, pancreatic, and adrenal tumors secreting growth hormones.
- Radiography is done to demonstrate skeletal manifestations of the excess GH or IGF-1
There is no single procedure that can achieve control over an excess of the growth hormone. Doctors usually recommend a combination of these treatments to cure gigantism and acromegaly:
- Surgery
Transsphenoidal surgery is regarded as the first line of treatment to remove a pituitary tumor if it is the one causing the excessive growth. This reduces the size of the tumor and the production of the growth hormone without causing a deficiency of other pituitary hormones.
If surgery alone is not enough to cure the condition because the tumor is already large by the time it is found, radiation therapy is used as a follow-up treatment especially when a substantial amount of tumor remains and hypersecretion of growth hormone still can't be controlled after surgery.
- Radiation therapy
This treatment uses supervoltage irradiation but it may take several years for the growth hormone levels to drop and go back to normal and it may affect normal tissues and cause deficiencies in other pituitary hormones. Stereotactic radiosurgery speeds up the results and spares the normal pituitary tissue. Heavy particle radiation which is only available in a few centers, permits the delivery of larger doses of radiation to the pituitary but poses a higher risk of hypothalamic and cranial nerve damage.
- Drugs
Medications can be taken to reduce growth hormone levels, prevent growth in stature, and block the effects of growth hormone:
- Somatostatin analogs such as octreotide and lanreotide suppress growth hormone secretion effectively.
- Dopamine-receptor agonists like cabergoline and bromocriptine mesylate are used as additional treatments to reduce the release of growth hormone but are less effective.
- Pegvisomant is a growth hormone receptor blocker that reduces or blocks the effects of growth hormone and lowers IGF-1 levels.


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Apparently one of the most popular shows currently on TV is House. I've heard of its multiple awards, and know many people who follow it very closely. Frankly, I never really felt much interest in it, and the teasers for it on TV struck me as annoying rather than appealing. Hugh Laurie's character seemed too harsh and cynical to me, and I didn't really understand why people were so drawn to the program.
Until now.
I happened to have the TV on last week when the show came on. I didn't feel like changing the channel, and ended up watching it. And I have to say that I became hooked, to the point that it annoys my wife. Besides the good drama, what appeals to me is the medical detective work. As a doctor (albeit for different species), I deal with diagnostic challenges daily. They aren't anywhere near as hard as those treated by Dr. House and his team, but the sometimes really challenge me. I enjoy watching the thought processes of the doctors, and how they work through their lists of possibilities to reach the conclusion. Other doctor dramas haven't captured my interest as much, since they seem to focus mostly on the interactions between the doctors and patients, or among the medical staff. House is different on several levels, and that uniqueness is what appeals to me.
So yes, I've finally joined the rest of America and seek out episodes of House. Now what I'd really like to see is a similar show based on a veterinarian!


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Undergraduate Scholarships
Academic Scholarships for Undergraduate Students in the College of Liberal Arts and Social Sciences
(Fall 2018-Spring 2019)
Deadline: Monday, April 22, 2019 by 5:00 pm
We will begin accepting scholarships on this webpage in mid-February
The College of Liberal Arts and Social Sciences each year awards numerous scholarships to honor students while they are in the process of completing a degree at the University of Houston. The amount of award varies for each scholarship and ranges from $500 to $2,500. Students must meet the following minimum qualifications to be eligible for a scholarship:
- Student must have a major declared in the College of Liberal Arts and Social Sciences.
- Student must have completed a minimum of 60 semester credit hours before Fall 2019. Seniors who graduate in December 2019 will receive half the total scholarship award for the Fall semester only.
- Student must be enrolled in a minimum of 12 semester hours during Fall 2019 and a minimum of 12 semester hours during Spring 2020, unless otherwise specified.
- Student must have a cumulative grade point average of at least 3.0 and maintain it for each semester during the Fall 2018– Spring 2019 academic year.
- Students will be considered for all scholarships for which they meet the donor's criteria, but will receive only one scholarship award.
When you are ready to apply, download the "Scholarship Application" below and carefully follow these instructions.
A complete application includes the following:
- Complete this coversheet
- Provide the following short essays in a separate document:
- Explain your involvement in college organizations, community activities, honors, special awards, etc. Please include any leadership or community/civic engagement (300 words maximum).
- Career Goals (200 words maximum).
- Financial Need: explain the circumstances of your financial need (200 words maximum).
- Personal statement: Why do you believe you deserve a scholarship? (500 words maximum).
- Secure a letter of recommendation from a CLASS instructor familiar with your academic work.
- Secure a current academic advisement report.
- Secure official transcripts from each outside college or university where you have earned less than 30 hours of course work while at UH.
Final Steps:
First, compile 1-5 above into a single PDF that is titled as follows: [Last Name First Name Major]. If an English Major named Anne Ramos applied for scholarships, her file would appear "Ramos Ann English.pdf," for example. Do not forward separate PDFs—compile all of your materials into a single PDF.
Second, forward your PDF to firstname.lastname@example.com by the deadline.
Deadline for Fall 2019 – Spring 2020 scholarships: Monday, April 22nd, 2019 by 5.00 p.m.
Incomplete applications will not be considered for a scholarship and late Applications will not be accepted!
Questions about CLASS Scholarships? Email us at email@example.com.


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estimated at 36 millions of souls. Of these, more than 30 millions are in Europe ; the Asiatic dominions of Russia, called Siberia, tho very extensive, being thinly peopled. Of the subjects of Russia, the most numerous part are the Russians proper, the Cossacs, and the Poles who have fallen to Russia in the partition of Poland.— To these may be added the Finns and Laplanders on the north west, and several Tartar nations in Siberia. Russia contains more than 50 different nations. 550. Language. The Russian language is of Slavonic origin, very rough, and of difficult pronunciation.— The letters of the alphabet are thirty six, with some unusual sounds, peculiar to the nation. The Finns speak a distinct language, as do the Tartars. The Polish is a mere dialect of the Slavonic. 551. Religion. The religion of Russia is that of the Greek Church, which was introduced in the tenth century. The chief point of difference between the creed of this and the Latin church is, that the Greek church believe the Holy Ghost to proceed from the father only. The rites and ceremonies of this church are nearly as numerous as in the Roman ; but while they admit pictures of saints into their churches,they reject images with abhorrence. All other religions are tolerated in Russia. 552. Clergy. The Russian clergy consist of three metropolitans, 28 bishops, and numerous inferior orders. The church is governed by a national council, called the Holy Synod, composed of a president, two vice-presidents, and nine other members. Marriage is forbid to the archbishops and bishops, but allowed to the inferior clergy. In Russia are 479 convents for men, and 74 for women, containing about 70,000 persons. The cathedrals and parish churches are computed to be 18,350. The clergy enjoy several immunities, especially exemp. tion from taxes. 552. Government. The government of Russia is an absolute monarchy. The emperor styles himself autocrator, or autocrat, which signifies one who governs solely by his own will. He must, by ancient custom, be of the Greek church. The empire is indivisible, *nd by a fundamental law of Peter the First, the reigning monarch has the right of naming his successor. The administration is committed to certain councils or persons appointed by the monarch, and Russia is divided into about 40 governments, of which 34 are in Europe, each intrusted to a viceroy or governor, whose authority is supported by a military force. 554 Army and Mavy. The Russian troops amount to 600,000 ; one fourth part of which are placed in garrisons to secure the dominions of the monarch in Asia and Europe. The Russian troops are among the best in Europe, being distinguished for disciplin and steady valor. The navy of Russia consists of about 36 ships of the line in the Baltic ; and twelve large ships, with many frigates, galleys, xebecs and gun boats in the Euxine. But the Russians are not distinguished for maritime enterprise. - 555. Revenues and Political Importance. The revenues are estimated at 50 millions of rubles or dollars, but the prices of labor and commodities are much lower in Russia than in the United States; and in supporting an army, 50 millions in Russia are equivalent to two or three hundred millions in America. In the present state of Europe, Russia seems to be the only government whose land forces are capable of resisting the enormous power of France. From the number of its hardy inhabitants, the extent of the empire, and its natural resources, Russia may be said to command the destinics both of Europe and Asia. 556. Customs and Manners. As the Russian empire contains many different nations, the manners are of course various. In the north west are the Laplanders and Finns, whose ugly persons and savage life have been described under the head of Denmark. The Slavonic Russians are of a middle size, with a fair complexion, patient of fatigue and hunger, brave and hospitable.— Having recently emerged from barbarity, they retain many rude and savage customs. Husbands keep their wives in subjection, and formerly used the rod, if necessary. The Russians are fond of convivial entertainments, and addicted to intemperance. They use the warm or vapor bath, followed by plunging into cold waO
ter, which, stimulating the skin very highly, guards them from cold and disease. o 557. Marriages and Funerals. A bride, on her wedding day, is crowned with a garland of wormwood ; and after the priest has tied the nuptial knot, his clerk or sexton throws upon her head a handful of hops, wishing she may be as fruitful as that vine. At funerals, the dead body is dressed, a priest is hired to pray for the soul, and to purify the body by a sprinkling of holy water.— When carried to the grave, a ticket from the bishop, being a passport to heaven, is put between the fingers of the deceased, and after the burial, the company return to the house, and drown sorrow by intoxication for a number of days, during which a priest says prayers over the grave, to aid the deceased on his passage to another world. 558. Punishments. The punishmentof certain crimes is remarkably severe in Russia. Peter the Great used to suspend robbers on gibbets, by iron hooks fixed to their ribs, until they died by torture. The knout is a severe punishment, consisting in scourging the criminal with thongs. In the double knout, the criminal has his hands tied behind his back, and by means of a cord fixed to a pulley, his shoulders are dislocated ; after which the thong is applied to his back, until scarified. This punishment often proves fatal. The boring and cutting out the tung are also practiced in Russia. These inhuman punishments are the remains of barbarism, which time and civilization will probably abolish.— Felons, after suffering the knout, are often sentenced to the mines, and men of distinction are banished to Siberia. 559. Travelling. The mode of travelling in winter is upon sleds drawn by the rane. The sled is made of the bark of the linden tree, lined with felt, and fixed upon runners. This sled is drawn upon the snow by that fleet animal the rane, a species of deer; or in the internal parts of Russia, by horses. When the path is well trod, a coach is sometimes set upon a sled, and the passenger, wrapped in furs, travels by night and day. The empress sometimes travels thus, in an apartment large chough to hold a bed, a table, and chairs for four persons. 560. Literature. Some learning was introduced into Russia with christianity, but it was not till the last century that Russia began to be distinguished for the cultivation of letters. Peter the Great gave great encouragement to learning, and succeeding monarchs have imitated his example. There are in Russia three universities, one at Petersburg, one at Moscow, and a third at Kiew. There is also at Petersburg an academy of sciences, an academy of arts, and an academy for cultivating the Russian language. There are some inferior schools, but the body of the people have no instruction in letters. 561. Chief Towns. Petersburg. Petersburg, now the seat of government in this great empire, was founded in 1703, by Peter the Great, on a marshy island in the Neva, near its entrance into the gulf of Finland, in the 60th degree of north latitude. No less than 300,000 workmen were employed, and in less than two years, a large town was built, and people were compelled to leave other parts of the country, for the purpose of taking their residence in the new city. At the same time, the emperor issued an order to draw the commerce of Archangel to this place. The fortress of Cronstadt defends the city on the side of the sea, and this is the port for the Russian navy. This city contains about 170,000 inbabitants. 562. Descrifition of Petersburg. Petersburg extends about six miles in length and bredth ; the streets are broad, and most of them paved ; some, however, are only covered with plank. Tho raised above the natural earth, the city is subject to be overflowed by the waters of the Neva, when driven back by violent westerly winds. The houses are of brick and wood, the brick being covered with stucco. In some parts of the city, the most elegant structures are intermixed with mean wooden houses. The houses of the nobility are magnificent, and the city contains buildings for every public purpose.— On the banks of the Neva is a palace built by the emPress, of hewn granit, ornamented with marble columns.
563. Statue of Peter I. In Petersburg stands a magnificent equestrian statue of Peter I. in bronze, cast at the expence of Catharine II. It represents the monarch in the attitude of mounting a precipice. He appears in a loose Asiatic dress, crowned with laurel, and setting on a housing of bear-skin. This statue stands on a pedestal consisting of a stupendous rock of granit, of 1500 tuns weight, which was moved by engines four miles on land, and then floated on rafts to the city. It is 42 feet long, and 17 feet high. The statue was erected on this pedestal in August, 1782, with ceremonies of great solemnity. -
564. Moscow. The largest and most ancient city in Russia is Moscow, so called from the river on which it stands. It is in the 56th degree of latitude, about 550 miles south easterly from Petersburg. Its circumference is 26 miles, but the whole extent of ground is not covered with buildings. That part of the city which is inclosed with walls contains by estimate 250,000 souls, and the suburbs about 50,000. The streets are long and broad, most of them are paved, others are floored with plank ; the city contains many gardens, and in the suburbs are cornfields and pastures.
565. Buildings in Moscow. In Moscow are seen the most wretched cottages and hovels, by the side of magnificent palaces, exhibiting a singular contrast of poverty and riches. Some of the brick houses have wooden tops, and some wooden houses have iron doors and roofs. The churches and chapels are computed at 1000 ; of these 484 are public ; some of them of brick, others of wood ; some have domes of copper, others of tin gilt or painted green. In some of these churches are bells of a stupendous size, one of which weighs more than 60 tuns. This city was the seat of the Russian government till the beginning of the last century, when Peter transferred the royal residence to Petersburg. In 1771, about 70,000 of its people were swept away by the plague. . 566. Trade and Institutions of Moscow. As Moscow is the center of the inland trade of Russia, which, by means of the Volga, is carried on to China and Persia,


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A Patchwork Life: Pam Henry
Although Mason resident Pam Henry doesn't have kids, she has her hands full with five Australian shepherds. As if five pooches weren't enough, Henry recently took in a new family member, Dusty, her new cat. Though she was unsure what her dogs would think of Dusty, the situation has worked out well.
"It went a lot better than I thought it would," said Henry.
Along with spending time with her pets and her husband Kevin, Henry also enjoys sewing and antiquing. Her tastes in antiques have changed — while once scrounging for various collectibles, Henry is now on the lookout for antique quilts and sewing items.
Quilting became a passion of Henry's more than 20 years ago. She came across a log cabin quilt in a magazine and thought, "I can figure this out." Her attempt brought her to one of her greatest passions.
At the time, she had only ever thought of being a surgery tech at an ophthalmology practice, a career she pursued with an education from Lansing Community College. This idea stemmed from her mother's occupation as a lab tech and a job shadow she did in high school. She realized she didn't want to be around a lot of blood, so she opted for ophthalmology.
She was a full-time surgery tech for 22 years at Lansing Ophthalmology. As time went on, her husband encouraged her to take a different direction and open her own quilting store because she enjoyed quilting with her friends so much.
"I fought it for awhile and kept saying no," said Henry. "But what woman would say no if their husband wanted them to have that much fabric?"
After pondering the idea a little further, Henry decided to take a swing at it, and has been happily overseeing her store, Everlasting Stitches, in Mason for seven years. The store took eight months to set up, and ever since Henry has dedicated her life to her store.
"My favorite part of the store is the customers coming back with their projects," said Henry. Henry does still work as a surgery tech one day a week.
"My day off is to go to the hospital and work, which I really enjoy because I don't have to make every single decision — every phone call is not for me," said Henry. "I'm not good with having nothing to do."
Henry admits that although she likes to keep herself busy, at the end of the day, she would "enjoy being able to have more time at home."
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Abby is a Contemplative Psychologist and currently works with the Center for Healthy Minds. Her career focus is the integration of contemplative practice and theory with clinical science. She teaches Contemplative Psychology and meditation locally and internationally. With expertise in prevention, assessment and treatment, Abby has offered her services in hospital, psychiatric and counseling center settings with individuals/groups, children/adults as well as couples/families.
In addition to the implementation of individual and group mindfulness-based interventions, Abby's scholarship also focuses on training and supervision. Using Community-Based Participatory Action Research approaches for treatment and program development, she aims to better understand and honor the lived experiences of patients and community members in her collaborations. Abby's recent work and emerging interests include assessing and enhancing community health and well-being.
During her graduate studies, Abby volunteered at the Center for Healthy Minds doing clinical assessment for the Veteran Wellness project, and most recently, she was a consultant for Healthy Minds Innovations. Currently as a postdoctoral research associate at the Center, Abby's work includes research activities and intervention support for the Well-Being Study and the Healthy Minds Program.
B.A., Psychology, University of Pennsylvania
M.A., Contemplative Psychotherapy, Naropa University
Ph.D., Counseling Psychology, University of Wisconsin–Madison
What does well-being mean to me?
"I view well-being very broadly, incorporating not only the psychological, but also physical, relational and spiritual dimensions of human experience."


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BSW Timber creates 25 new jobs at Newbridge-on-Wye sawmill
Published: 24 November, 2011
POWYS: BSW Timber's ongoing investment in it's sawmill at Newbridge-on-Wye has continued with the news that the company is to create 25 new full-time jobs at the mill.
The announcement follows conditional planning consent for the Newbridge Mill to extend its working hours. BSW has already invested £1.8 million in the Newbridge mill this year with the installation of two 3 megawatt biomass boilers to provide process heat for kiln drying timber. This is one of the UK's largest biomass hot water boiler plant and should benefit from the Government's Renewable Heat Incentive. This investment was also supported by the Welsh Assembly through the Wood energy business scheme.
This adds to the £6 million already invested in the mill during the past five years, which now employs 120 staff, making it the largest single site sawmill in Wales.
Dave Burd, Newbridge Mill manager, said: "This conditional planning permission will allow us to operate more effectively and efficiently on site, and significantly increase production levels at the mill. This is good news for the business and good news for the local area as we continue to expand our workforce at the mill."
Local MP Roger Williams, added: "As a rural employer, BSW Timber has a critical role to play in maintaining local wealth and employment. They have shown over the past five years that the operation at Newbridge-on-Wye is going from strength to strength, thanks to a rolling programme of continued investment in plant, people and environmental improvements."


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Three videos taking a look at how Japan evolved during the medieval period.
The first video, by Hurricane Hunter03, shows the history of Japan from 4000 BCE to 2018 CE, and offers a good look at the internal border changes when Japan was split into various competing states.
Mapping History has also created a good video, starting in 1185 and going to present
Finally, for a broader look at the region, take a look at EmperorTigerstar's video showing East Asia
You can also watch this video on The Japanese Animated History In a Nutshell from Knowledgia
See also: How the borders of China changed in the Middle Ages


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No need to front, aspiring Nerdcore MCs! Taito has teamed up with Christofle, manufacturer of all things shiny and expensive, to sell these kick ass Space Invaders necklaces, which should turn even the most unsightly nerd into the belle of the Players Ball.
Above: Possibly inspired by Le Tete au Cube, a French site we couldn't read
Get a good look, because judging by the prices of everything else on the website, none of you will be able to afford it. Luckily, I'm a high rollin' Gamez Journalist and mybank account's got more zeros than the binary code of yo mama's Facebook profile, so I'll probably pick up several. And it's about time too, since my old 8-bit ice is getting a little stale:
Above: Don't hate - just appreciate
Apr 28, 2010


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After a leak last month, Rebellion officially announced today that Sniper Elite 4 is coming to PlayStation 4, Xbox One, and PC in 2016.
Set in Italy in 1943, Sniper Elite 4 is a third-person stealth action game that follows elite marksman Karl Fairburne, who "must help free Italy from the yoke of Fascism and defeat a terrifying new threat that could halt the Allied fightback in Europe before it's even begun."
Running at 1080p on PS4 and Xbox One, Sniper Elite 4 includes a campaign for one to two players, as well as dedicated co-op and adversarial multiplayer modes.
The description adds:
From sun-drenched Mediterranean coastal towns, to colossal Nazi megastructures, daunting forests and giddying mountain monasteries, Sniper Elite 4 will offer breathless emergent stealth action and unrivalled sniping freedom across maps many times the size of those seen in Sniper Elite 3.
Discussing the above trailer, Rebellion Creative Director Jason Kingsley said, "Just to stress, the footage isn't pre-rendered or taken from cutscenes. What you're seeing in the trailer is taken from environments you'll actually be playing in."
Are you excited for Sniper Elite 4?
[Source: PlayStation Blog, Sniper Elite 4]


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Most women who get breast implants are happy with their results. On the RealSelf website, 98% of actual patients say breast augmentation is "worth it," which reflects what I hear from my breast augmentation patients in Boston. At some point, however, many women need breast augmentation revision surgery, and I make sure patients understand that …Read More
Christopher J. Davidson, MD
Fraser Medical Building
332 Washington St, Suite 100
Wellesley, MA 02481
Phone: (781) 237-7700
Monday–Friday: 9 a.m.–5 p.m.
Category Archives: Breast Augmentation
Getting the opportunity to expand your wardrobe—including new lingerie options—is one of the best perks of breast augmentation. When women get breast implants at my Boston, MA, practice, they are often very excited about buying their new bras in styles they may not have been able to wear before. However, I am careful to advise …Read More
Whether you're considering a tropical vacation, attending a wedding, or even wowing your old friends at a high school reunion, you're likely hoping to look your best this summer. If you're thinking about plastic surgery here in Boston, the winter months can be the perfect time. Not only will winter's heavy clothing and layers conceal …Read More
When women come to my practice in Boston for breast implants they often have one overriding concern: scarring. I understand their trepidation. After all, what good is a beautiful surgical result if it's marred by noticeable scars? In order to meet my patients' demands, I've devoted a significant portion of my professional life to learning surgical …Read More
At my Boston plastic surgery practice, the popularity of breast augmentation continues to increase. This surgery has one of the highest patient satisfaction rates of any cosmetic procedure, and for good reason. Advanced breast implant technology has enhanced surgeons' options for creating natural-looking results, and modern surgical techniques and pain management protocols have made the …Read More
Fall is often thought of as a season of changes. Leaves change colors, the weather turns chilly, and, with the beginning of a new school year, children change grades. At my Boston plastic surgery practice, it's also a popular time for patients to pursue personal transformations that they may have been thinking about for months …Read More
Directly following your breast augmentation procedure, you may feel groggy; this is more likely when you have had general anesthesia, as opposed to twilight sedation. That being said, general anesthesia is typically considered much safer than twilight anesthesia, or sedation, since under general anesthesia an anesthesiologist (MD) is present and monitoring you the entire time. …Read More
Approximately 90 percent of all women have breasts that are different sizes. For some, it's a small, unnoticeable difference; for others, it can be very obvious and thus a source of insecurity. Breast augmentation or reduction surgery can improve the symmetry of a woman's breasts while maintaining a natural and aesthetically pleasing look. Why Are …Read More
Last year, breast augmentation was performed on almost 300,000 women and remains one of the most popular choices in cosmetic surgery. We're here to help you with that process by providing some recommendations and a basic understanding of breast implants. Information on Implants You'll hear doctors and media sources refer to implants as "cc" of …Read More
Every cosmetic surgical procedure has its fair share of misconceptions that are strung along by critics, anti-supporters and people who remain neutral. Breast augmentation continues to rise to top of the list of cosmetic surgeries, year in and year out. Today, women who wish to have firmer and bigger breasts are more likely to do …Read More


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GenoKey has extensive experience in scientific computing and has developed a suite of innovative technologies for solving very large-scale combinatorial problems. Our array- based approach provides very efficient and scalable methods for combinatorial data mining on case-control data with large number of biomarkers, including genetic and clinical data.
Our technology was developed in close cooperation with leading research centers and has been tested on large biological data samples, as described below.
Genome Wide Association Studies
Genome Wide Association Studies (GWAS) attempt to compare the genotypes of a population of patients with a specific disease against a control population to identify signals that are associated with the disease. These signals are usually single base mutations (Single Nucleotide Polymorphisms or SNPs) at specific points in the DNA. Tests based on these signals can be used as research tools or companion diagnostics to help prescribe drugs only to those patients who can benefit from them.
Existing GWAS methods generally identify single (or at most pairs of) SNPs. Very often however, these associations are found not to be significant and cannot be validated clinically. Unfortunately the simplistic 'SNP at a time' view fails to reflect the biological complexity and often misses crucial factors – rarely explaining more than 50% of the disease risk that is seen. This means that key associations between SNPs may not be spotted and hence cannot be used as tools in research on the disease. The closing of this 'heritability gap' is a major current undertaking in the analysis of GWAS data*, and will lead to innovative new drugs and diagnostics products with significant commercial value.This is not surprising – complex diseases such as diabetes, bipolar disorder and cancer are highly multi-factorial, with combinations of several factors combining to exert a clinical effect. In these important diseases, one or two SNP variations by themselves have little or no predictive value.
To understand the complex network of metabolic influences on the disease we must therefore find sets of several SNPs that, in combination, are associated with different disease variants and treatment outcomes. This represents a massive computational challenge for traditional approaches due to the number of potential combinations. Assuming that we want to select p SNPs at a time from a total of n, the number of SNP combinations is n!/p!(n-p)!. A graph illustrating the factorial expansion for sets of between 3 to 10 SNPs in a 500,000 SNP genotype is shown below (note the log scale):
To overcome this challenge, we use a highly efficient geometrical approach based on nested data arrays combined with high performance massively parallel GPU processing. The massive data analysis capability that this provides, allows very fast and complete examination of all potentially valid SNP combinations to find statistically significant genotype patterns for your studies. Large GWAS studies on 3 SNP sets can now be run in minutes even on relatively low-cost GPU hardware.
For more information on the large scale bipolar disease study undertaken with University of Copenhagen please see here or online at http://dx.plos.org/10.1371/journal.pone.0023812.
* Zeggini E., (2011) Next-generation association studies for complex traits, Nature Genetics 43, 4, 287-288


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Get up to 500* cash on-the-spot once you sign the Job Offer this August! Terms & Conditions apply
Big brands. Great opportunities. Awesome benefits.
Those are what we offer in our Telecommunications account. Provide over-the-phone support for clients across North America. Help them out with billing inquiries, plan upgrades, basic account error troubleshooting, payments processing, and online applications.
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Salary: ₱15000 - ₱30000
Address: G/F Glorietta 1 Corporate Center, Hotel Drive, Ayala Center


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Yes, this one's going out to all the daughters who want a piece of that hot Bridgeport ass. It's the third commercial in the First Act / Volskwagen promotion of "buy a guitar — get a car." Or was it "buy a car — get a guitar?" We don't know, but either way, you'll end up getting both on the 2006 and select 2007 VW models on sale now at dealerships.
Volkswagen / First Act Promotion [V-dubsrock.com]
Ad Watch: Move Over Stormare, Slash's Representing VW, Deutschland Now!; You Can't Dust For Vomit: Nigel Tufnel Shills For VW [internal]


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Mother of pearl inlay furniture
Moroccan furniture
Unique furniture
Carved furniture
Moroccan bedding
Lounge chair
Mosaic tables
Wrought iron
Moroccan home decor
Moroccan ceilings
Moroccan Doors
Sink cabinets
Moroccan tile
Garden pottery
Plaster artwork
Moroccan fountains
Moroccan lanterns
Stucco floor lamps
Moroccan lamps
Large chandeliers
Henna lamps
Moroccan sconces
Camel Bone Mirrors
Antique pottery
Rugs & Kilims
Room divider
Moroccan Fabric
Moroccan gifts
Moroccan tagine
Moroccan Poufs
Unique gifts
Interiors books
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Closing the Sale
To finalize the sale of the home a neutral, third party (the escrow holder, a.k.a. escrow agent) is engaged to assure the transaction will close properly and on time. The escrow holder insures that all terms and conditions of the seller's and buyer's agreement are met prior to the sale being finalized, including receiving funds and documents, completing required forms, and obtaining the release documents for any loans or liens that have been paid off with the transaction, assuring you clear title to your property before the purchase price is fully paid.
Upon completion of all instructions of the escrow, closing can take place. All outstanding payments and fees are collected and paid at this time (covering expenses such as title insurance, inspections, real estate commissions). Title to the property is then transferred to the seller and appropriate title insurance is issued as outlined in the escrow instructions.
At the close of escrow, payment of funds shall be made in an acceptable form to the escrow. As your real estate agent, I'll inform you of the acceptable form.
Mortgage Escrow Account
A Mortgage Escrow Account is established to pay on-going expenses while there is a loan on the house. These expenses include property taxes, home insurance, mortgage insurance, and other escrow items. Generally, the Escrow Account is partially funded at closing and the home buyer makes on-going contributions through their monthly mortgage payment.
Diamond Mortgage, LLC
10735 Sky Prairie Street, Ste 300
Fishers, IN 46038
10735 Sky Prairie Street, Ste 300
Fishers, IN 46038
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All loans subject to credit approval. Loan programs vary according to state, and are subject to change at any time.
Diamond Mortgage, LLC will make every attempt to make any updates and corrections in a timely fashion. Diamond Mortgage, LLC is an Indiana based mortgage company (Indiana Loan License# 96-0222 LB). All information provided to Diamond Mortgage, LLC will not be sold or given to any third parties as we respect you privacy.
Diamond Mortgage, LLC 10735 Sky Prairie Street, Ste 300 Fishers, IN 46038
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A Florida police officer who allegedly ignored pursuit orders before violently ploughing into an innocent man's car while travelling 164 km/h will face trial in two weeks.
Palm Beach County Deputy Sheriff Brandon Hegele smashed into a small smart car on May 7, 2016, sending the 60-year-old driver to hospital with terrible injuries.
Harry Deshommes suffered a brain injury, fractured skull, a broken left arm, back, ribs and pelvis and had to have his spleen removed, according to court documents.
Deshommes had no chance to see the police car closing in on him from behind.
Crash investigators claim Hegele was travelling at 164 km/h in an 80km/h zone without using his lights and siren.
Investigators said Hegele had ignored three orders to not pursue or try to stop the vehicle of a felony suspect, The Sun Sentinel reports.
Dashcam footage shows Hegele changing lanes nine times and only using his lights and siren as he raced through intersections, investigators claimed.
The trial of Hegele on reckless driving charges will begin on August 28.
Hegele has been on unpaid leave since September last year.


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What Happens After An Accident At Work?
For many people that experience an on-the-job injury, the process can be very confusing. Suddenly you are going to medical appointments, missing work, dealing with insurance companies, as well as dealing with your painful injuries. Here is some general workers compensation information you likely will need as you go through this process.
The Reporting Stage
If you miss at least five days from work your employer must file a Form 101, First Report of Injury. Keep in mind the five missed work days do not need to be consecutive days.
The employer then has seven days to file this report. The form is sent to the employer's workers comp insurance company.
Upon receipt of the Form 101, the insurance company has 14 days to either pay for the benefits claimed, or to deny it. Keep in mind many claims are denied at this stage. If they are denied, a Form 110 is filed to contest this denial.
The Medical Treatment Stage
During this part of the process you are actively going to doctors and therapy. Keep in mind you can go to whichever doctor you choose to go to. The only time you need to go to the workers comp insurance company's doctor is for an Independent Medical Exam.
The insurance company is only required to pay board rates for approved medical treatment that has gone through the process of utilization review.
The Court Stage
When either the employee or insurance company contest any aspect of workers comp benefits claimed by the injured worker, the Department of Industrial Accidents is where a claim is filed.
This court does not have juries. Also, this is not a court where lawsuits are filed. Rather, this is an administration law court that strictly handles claims for benefits filed by injured workers, and claims contested by insurance companies.
This court is composed of conciliators and judges who screen these cases, attempt to resolve them, and when necessary, decide which, if any, benefits the injured employee is entitled to.
A Massachusetts Workers Compensation Attorney
If you are going through this process alone and feel it is time to consult with an attorney, I encourage you to call us at 617 338 7400 for your free, no-obligation consultation. The Law Office of Christopher Earley is here to help you with your case.


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Valentine's Day is almost here! A day full of love, gifts and last minute arrangements. Fear not if you still haven't decided on where you will be taking your other half – we're here to save the day!
We've scooped up a range of restaurants who are offering Valentine's Day menus and are still taking bookings for all those last minute couples.
Miller & Carter | Mailbox
Located in the Mailbox, Miller & Carter have a chef's special menu available for Valentine's Day, which includes a fine range of dishes from whole lobsters to a sharing Butcher's Block. Perfect for you and your date to enjoy over a bottle of the finest wines available at the restaurant. Book your table here!
Ju Ju's Cafe | Canal Square
Based in the Canal Square, Ju Ju's Cafe is also offering a set Valentine's menu for only £24.99 per person. Known as "the hub for fab fresh food" the restaurant is offering a mouth-watering three-course meal for you and your partner to enjoy, beside a cosy canal-side view. Book your table here!
Jamie's Italian | Bullring
Jamie's Italian is offering a special three-course menu for £29.95 per person. For a memorable day, Jamie's Italian have created a Valentine's Menu to share, featuring its famous sharing planks, favourite dishes and a glass of bubbly each. You can book your table here!
Everyman Cinema | Mailbox
If you're still planning on watching La La Land or Fifty Shades Darker, why not take your date to the Everyman Cinema at Mailbox. With great food and cocktails at the bar for under £20 per person and sofa seating in the cinema room, this date experience is perfect for a relaxing night with a home-like feel. Book your tickets here.
Hire a private chef
You may really fancy a night in with your loved one but have no idea what to cook. You can now hire a private chef who will arrive at your home with fresh ingredients to cook a delicious meal in your kitchen. The chef will ring you prior and ask you for your recommendations, they will then cook up a four-course meal for just £90 per person. There is still time to book your chef here.


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If you expressly choose to provide us with your Personal Information, we will use it to send you Pastime via email. You may opt out of receiving Pastime at any time by following the unsubscribe link provided in every email we send.


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American Trailer Wholesale aka My-CargoTrailer.com is owned and managed by AAA Trailer Distributors Incorporated. We are a legal trailer dealer (#001103287469) and insured corporation able to distribute trailers anywhere!
This site was designed to bring all the best deals on cargo trailers to one website. This makes it easier for the customer to choose which trailer they want, knowing they are getting the absolute best price possible.
Our easy to use website allows the customer to choose a model, build it how they want, then price it right from the website. Then the customer can choose to print the quote (for later use), send it to a sales associate for assistance, or proceed to checkout online thru paypal or credit/debit card.
Our experienced staff can help assist you with choosing the right model for you and answer any question you have regarding trailers. We gladly accept credit or debit cards, paypal, personal or certified check or cash for deposits. Cash or certified funds only upon pickup of trailer at factory.
We usually keep the most popular models in stock or can have a trailer built within 2-4 weeks depending on model & options. You will receive the best price everytime on all models. We also offer financing or leasing programs on all models of trailers. You may choose to pick your trailer up in Georgia, have it shipped to a meeting location, or shipped directly to your door.
We make buying trailers easy. Call us today toll-free 1-866-995-0336 or 1-877-343-6383. Thank you for choosing American Trailer Wholesale and we hope to see you soon!


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It is believed that the Komondor is a descendant of the Tibetan dog, and it was brought to Hungary by nomadic Magyars a thousand years ago, in order to guard flocks of sheep. However archaeological evidence suggests that the Komondor was, in actual fact, the dog of the Cumans, or Komans, from light yellow or pallid, who were a Turkic speaking community that lived close to the eastern bend of the Yellow River in what is now China.
The Russian Owtcharka was the original dog that had long legs and a wooly coat which enabled it to blend in with the flocks that it was protecting. This breed was valued so much by the shepherds that they did not allow interbreeding. The Komondor, whose plural is Komondorok, was a great foe to enemies of the flock and it is legendary that it eliminated the wolf from Hungary.
The earliest record of the Komondor dates back to the sixteenth century, although the breed most probably existed for a great deal of time before that.
Documentation was spread throughout the rest of the world in 1920 that the Komondor was presented at dog shows. The Komondor made its first appearance in America in 1933 and was officially acknowledged by the AKC in 1937. This breed is capable of living outdoors in all types of weather as a protector of its master's flocks, just the same as it did thousands of years ago.
This breed is known as the king of Hungarian sheepdogs. It primarily serves as a home and livestock protector in the United States.
The Komondor has a coat of a dreadlock appearance, which gives a hint of common origin with the Puli and Bergamasco. It is also possible that there is a link between the Komondor and the big white Russian livestock dogs, which are called the Southern Russian Ovtcharka.
There dreadlock coat had to be developed in a dry and extreme climate, as it provides fantastic protection against the cold and also hot weather. However it is not too comfortable for the dog when it gets wet.
Many Komondorok were killed during the Second World War.
Local stories say that this is because, when the Nazis, and the then Russians, invaded, they had to kill the dog before they could take over a farm or a house that had a resident Komondor.
The Komondor is a serious, confident, alert and authoritative dog. However, they can be very stubborn or bossy with other dogs. The Komondor is very protective of its territory and family, which makes it a great guard dog.
The dog interacts well with other pets, especially livestock, as it believes that it has something to watch over and protect, which ultimately makes it happy.
It is essential however, that a Komondor receives intensive exercise. They require daily exercise which can include long walks, long-distance runs, short romps and pulling. Swimming is discouraged however, as their coats take such a considerable amount of time to dry. Warm weather is not preferred by this breed of dog. The ideal living environment for a Komondor is in the country.
However, it is possible for the Komondor to live in an urban environment also.
- Loyal, Dignified, Brave
- AKC Breed Popularity: Ranks 173 of 191
- Height: 27.5 minimum inches (male), 25.5 minimum inches (female)
- Weight: 100 pounds or more (male), 80 pounds or more (female)
- Life Expectancy: 10-12 years
- Group: Working Group
Komondor Club of America


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Tag: airport
Autorsko | | 10. travnja 2018. 08:08
Travelogue CROATIA IN GEORGIA: Without boarding pass in the wrong airplane
Leo called me again: – Tamara, do you want to go to Georgia? Five days of APV in the end of October and 10 days of project in the first…
Turističko | | 25. prosinca 2016. 22:00
Travelogue "CROATIA IN GREECE": Gods decided to live in Greece. Now I know why.
Domino effect. I went to Italy to participate in project. I met Panos, we became friends. Skype, Facebook, we started making deals about cooperation. I already made arrangements for project…


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This wall-mounted Terrus mixer and spout is a popular choice for the basin or the bath. It is part of the latest in bold contemporary bathroom styling and it utilises the latest in ceramic mixer cartridge technology. It is of course fully certified to Australia's Watermark standards and Wels water ratings.Read more
Terrus Single Lever Mixer and Spout - Wall Mounted
Aguzzo Product Code : RSEEO520B0019
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Item dispatched in 1 - 2 business days All our products are stocked in Australia and are ready to ship to you.
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- Height: 100mm
- Width: 220mm
- Depth: 190.5mm
- Material: Solid DR Brass
- Finish: Polished Chrome
- Watermark Approved: certified under AS/NZS 3718
- WELS Rated: 3 Star, 8L/Min flow restrictor in accordance with AS/NZS 6400
- WELS Registration: T12723 - 20 8051 99
- Warranty: 5 Years
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text: Atrium Health is currently seeking Board Certified or Board Eligible Child Neurologists to join their growing team located at Atrium Health Levine Children?s Hospital in beautiful Charlotte, North Carolina and Jeff Gordon Children?s Center in neighboring Concord, North Carolina. The division presently has 8 Child Neurologists, including 4 Pediatric Epileptologists. In addition, 4 Nurse Practitioners complement the team between the two primary locations. Candidates should demonstrate a commitment to clinical excellence, education and research development. Carolinas Medical Center is a major teaching affiliate of UNC at Chapel Hill School of Medicine. This position would include shared call and inpatient consult responsibilities balanced with outpatient clinics and potential for satellite outreach. Collegiality and professionalism are values of greatest importance. A competitive salary, incentive bonus and attractive benefits are offered.


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Podcast 99 -Making Linkedin Work For Your Business With Mike Shelah
Podcast: Play in new window | Download
LinkedIn is a super powerful and important tool for professionals. When used correctly LinkedIn can help you build your network, find and get introduced to your ideal prospects, and show your value and worth to the world.
In this episode, my guest is Mike Shelah. Mike is a LinkedIn expert and consultant. He helps businesses to understand and get more out of their efforts on LinkedIn.
Here's a sneak peek at what Mike and I talked about in this episode:
- How and why to optimize your LinkedIn profile so you stand out from the crowd
- I challenge Mike to prove me wrong about things I HATE about LinkedIn
- Attracting the right people to your profile
- LinkedIn SEO
- Is it worth it to pay for their premium services?
- An action plan for prospecting on LinkedIn
Learn more about Mike Shelah here. And don't forget to leave your thoughts, questions and feedback in the comments below.
A question for you
The next episode of this podcast is a big milestone. It will be the 100th episode.
So I have a favor to ask. I'd like to know what you get out of this show. What do you like, don't like, want more of, etc. I'd like to include all of you who listen each week in this special episode.
So leave a comment below and let me know what you like most about this show. Or, you can be a live guest by going here to record an audio.
1 Comment
Thank you for interviewing me
Since this interview have learned a technique.
I add people to my email spam list without their permission and put it on them to unsubscribe I put a silly disclaimer at the bottom of the email telling them they got the spam because they subscribed to my website. Of course this is baloney.
I know it's an evil technique, but then again I am evil Mike Shelah [email protected]


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We continue our summer worship series, Notice Grace All Summer, with reflection on Crossfit & church this Sunday.
How was fitness a part of your childhood? How do you relate to fitness today?
Crossfit is a rapidly growing fitness program started by Greg & Lauren Glassman in 2000. Over 3,400 Crossfit gyms have opened in the last twelve years across the county. In an article titled "Understanding CrossFit" (April 2007) Coach Greg Glassman writes, We sought to build a program that would best prepare trainees for any physical contingency—prepare them not only for the unknown but for the unknowable as well. The CrossFit prescription is "constantly varied, high-intensity, functional movement." … The methodology that drives CrossFit is entirely empirical. We believe that meaningful statements about safety, efficacy, and efficiency, the three most important and interdependent facets of any fitness program, can be supported only by measurable, observable, repeatable facts; i.e., data. We call this approach "evidence-based fitness."
Worship this coming Sunday will invite us to consider what the church might learn from Crossfit.
Our Scripture this week is Psalm 52. This is a difficult Psalm to comprehend. In essence, the Psalmist cries out in this song for God to ultimately overcome those whose lives are unjust and deceptive. The Psalmist closes this song by comparing themself to an olive tree in the house of God. The image echoes Jeremiah 11:16 which states, "The Lord once called you, 'A green olive tree, fair with goodly fruit'; but with the roar of a great tempest he will set fire to it, and its branches will be consumed." It seems the Psalmist invites us to consider how might we be like a green olive tree with deep roots. If we fail to have deep roots, our fruit too will wither.
What evidence do you have that your roots are deep and your fruit is "goodly"? How are you deepening your roots these days? Think back on your goals for the year regarding rooting your life in Grace and growing in faith and reaching in love. How are you doing with those goals? If you don't have goals at this time, what might it be like to identify a goal for one of these areas?


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ST JOHN'S — Her Majesty's Prison bosses on Saturday reportedly buckled to pressure from frustrated inmates – mainly convicts – after the prisoners went on a brief hunger strike and refused to return to their cells until the superintendent heard their grievances.
The inmates, who eventually had a preliminary meeting with Superintendent Percy Adams on Saturday afternoon, reportedly raised concern about their overall treatment in the facility.
Narrowed down, the issues include inmates' lack of access to proper nutrition and health care, the unsanitary condition of the facility, withholding of their bi-monthly toiletries and alleged favouritism towards some inmates by wardens, among other issues.
During the near eight-hour stand off, someone claiming to be an inmate, and who did not identify himself, called into a programme on a local radio station and complained about the aforementioned matters and the alleged abuse of power by some of the prison staff.
The phone call sparked a debate on the radio station, with residents expressing fear there could be a deadly riot or jailbreak, given the prisoner-to-warden ratio at the severely overcrowded and understaffed prison.
They urged the authorities to go to the facility and arrest the situation before it got out of control.
Just around noon Saturday, one of OBSERVER media's staff got an overhead view of the prison yard from a nearby building and the scene was far from aggressive and confrontational.
Inmates were seen in the yard milling around, talking to each other. Wardens, including two females, were also on the compound.
Deputy in charge at the prison Colonel Glynne Dunnah later arrived, followed by several police officers.
After some discussions, a source reported, it was agreed five of the inmates would be allowed to meet with Adams.
Having raised their concerns with the prison boss and received a promise they would be afforded a follow-up meeting today, the five inmates and all the other prisoners ended their protest and accepted their meals, a source revealed.
Efforts to reach Adams and Dunnah over the weekend were unsuccessful.
Currently, the prison, built to accommodate 150 inmates, houses in excess of 360. In some cells, there are as many as a dozen inmates who share a pail to urinate and defecate. (Antigua Observer)
Prison bosses respond to hunger strike - by Barbados Today September 9, 2013 Article by
Barbados Today Published on
September 9, 2013
Article by
Barbados Today
Barbados Today
September 9, 2013