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Friday 29th April 2016
What a blessing it is to hear from Elder Fesolai this evening.
Elder Fesolai's new companion is Elder Bulunga. Elder Bulunga is from the D.R. Congo and has only been out 4 months. He speaks very little English and speaks mainly French. Elder Bulunga does online English assignments every Friday morning for 2 hours at the internet cafe, so we get to hear from Elder Fesolai. How awesome is that.
Elder Fesolai says he is definitely out bush and the dialect the locals speak is Ewe. So, he says will try and pick it up as quickly as possible as being in Nungua for the last 10 months they mainly spoke, Twi and Gha.
Bushionary is what Elder Fesolai is calling himself now that he is serving out bush in Juapong. They are in a Branch and his Mission President told Elder Fesolai that more than likely he will be called onto the Branch Presidency to assist the Branch President and serve in a leadership position amongst the saints there. President Heid has asked him to practice playing the piano as he will be playing the organ at church as well.
Elder Fesolai discribes his new area as "The Garden of Eden" Its just green, green, green. With mountains and Mango tree's all over the place. Its open slather on the mangoes too. Elder Fesolai said it has been humbling to prosylte in the outer villages in their mud huts.
So here are some pics of the new area!
So here is a pic of the mango tree near our apartment lol...too much enjoyment!
A pic of the mountain at the back of our apartment
Elder BULUNGA!!! Mr French man hahaha!
And the mountains in a place called mataiko!
It's really really pretty out here, and very different from Nungua!
Monday 18th April 2016
Well we are back again!
Hey Mom and Dad!
It seems like time is going by faster and faster every week! This past week kinda just flew right by! Nonetheless it was a great week! We have been really doing a lot of finding and contacting again. Our teaching pool isn't too bad, but we are building it. At the same time I'm trying to go around all the area and contact so Elder Frandsen can get to know the area well. So we had a fun week talking to a lot of new people, and sharing the Gospel with them! Looking forward to seeing how they progress though!
The work seems to be going forward I'n Nungua District! We dont have any baptisms coming up this April, but in the first week of May we should have some! So, we are working really hard to help those people progress! I had some baptismal interviews to do this week which was interesting! It's really amazing to see the sincerity of people wanting to covenant with God and follow Christ!
Theres not a whole lot to tell you's about this week, so sorry this email is kind of short! I'm expecting to be transferred in the coming weeks, so it will be interesting seeing where the Lord needs me next! It will be another awesome learning curve! Going from a place that I know so well, to a new area! I't will be great to meet a whole lot of new people I'm sure!
Everything is going pretty well in Nungua though. We have quite alot of people to follow up on that we have met this past week so that will be fun. It will be interesting to see how many are really sincere and serious in learning too!
Hope you's have a wonderful week though! love you!
Elder Fesolai
So, the pics I have from this week are small haha! Please manage it!
So, Elder Kambwiri and I. He's one of the Elders in the District! I went to interview one of their candidates on Friday.
This little boy namedIsaac. He is a thug lol!
And a pic with me and Godwin! Haha this guy is so awesome! One of the reasons I'm so grateful to have served in Nungua for some time! To see this guy progress!
Anyway, till next week!
Monday 11th April 2016
Hey Mom and Dad!
So what a busy week it has been in Nungua! Where do I begin?
So we had Zone training this week on Tuesday, which was pretty good. The whole Zone came down to Nungua chapel so it was pretty sweet! Talked alot about the link between the Atonement, Grace and Humility! There were some interesting discussions and insights to be had haha!
The Zone Leader's conducted some exchanges this week too. So on Tuesday I was on exchanges with Elder Harrigfeld as his companion (who is the DL) was with one of the Zone Leaders so Frandsen when to the other Zone Leaders Area. So Wednesday and Thursday I was with Elder Okeke. He's from Nigeria! So that was super awesome to work with him for those 2 days. It's always fun and interesting working with other missionaries, seeing how the teach and go about the work. There is always so much you can learn from other people!
Elder Frandsen and I were able to go to the temple on Friday too which was awesome! We got permission from President to go, so it was an awesome opportunity! It is always so so nice to go to the house of the Lord and do temple work! We are blessed to have a temple in Ghana!
Overall this week has been a real busy one! We've been able to see and teach so many people! We spent about 3 days just going around and contacting and finding on the streets which was absolutely fun haha! It is always great to meet and talk to new people about the Gospel!
We are planning to do alot of teaching with Godwin Selom this week! Some crazy news! So he is currently preparing for a mission. He was talking to Bishop on Sunday, so that was exciting news! He will have been a member for 1 year in September so still 5 months away. But it's great to see that he has it as a goal and priority! It has really been so amazing to see how that guy has progressed over the short time I've been here! The miracle of change that the Gospel brings is too real!
Missionary work is awesome though! I've been studying the Book of Mormon again. I've come to love that book so much since I have been out. It's one of my firsts places to turn to for comfort, council, and knowledge and understanding! That book really helps us draw closer to God and continually build our testimony in the Savior and his Gospel. It is a great blessing to have it in our lives! It's really written for our times!
Everything is cool in Nungua though! We are planning to work with the members and Bishopric this week so it should be good. This Sunday at Ward Council Bishop Karikari brought up some awesome ideas to reach out to less actives.
Hope you guys are doing well though! Work and all is going good? Love yous!
Elder Fesolai
So they pictures have returned! Sorry it's been a while! Alot has happened this week though so I took alot of pics haha!
We went to the temple on Friday which was awesome!
Tuesday and Wednesday were exchanges. The fair guy is Elder Harrigfeld, then I was on exchange with Elder Okeke, he's one of our Zone Leaders. Super cool ELders!
I saw Obed on Sunday, we dont get to see them much since theyre in the other ward, so I snapped a pic with him. He was trying to beat me up with that hymn book....
We were at one of my RC's house Kingsley. He's Nigerian and he made us Aba and Agusi stew! It was sweet! In that pic is ELder Ochieng, Winborgs new comp. He's from Uganda and goes home soon!
And then we caught up with Koronikalou, mr fiji!
Monday 4th April 2016
Hey Mom and Dad!
So what a week it has been! So I got my new companion on Monday evening last week! What a relief that was! Being a solo missionary for a few days was definitely not my most favorite experience out here! His name is Elder Frandsen and he's from Utah! Pretty cool guy! We've been working really well together, and he is learning the area fast!
Haha this past week we were enjoying seriously! I really love this area so much and have just gotten to know the members so well! Last week, everyday we had FM's which was a record! The work has being going well. We have been able to go and teach with members and work really closely with the Ward mission leader which has really helped in our proselyting efforts. Having a local member from the ward with us just makes it so much easier in quickly killing false concerns or beliefs in the church and getting straight into lessons! We really have been blessed!
Last week primarily we just had been doing a whole lot of finding and contacting which is always a fun thing to do! Get to practice and work on my Twi and Ga skillz lol! The work is doing great though! Everybody in the Zone is starting to recognize that I've been here for quite a while now so amongst the missionaries I'm "nungua man" now apparently! Ah well!
Been working alot with Selom though! We see him quite regularly! He will come and proselyte with us this week I'm sure! So it will be great! It has been awesome to see the miracle of repentance and change that the gospel brings in his life! He is one of my closest friends out here! He loves french toast too much too hahahaha!
We have some baptisms coming up at the end of the month which should be exciting! I'm really looking to extend some more this coming week! So far in Nungua we have had 17 baptisms which has been nice. It's really cool going to church and seeing all the people you've taught just striving their best to stay strong!
Being district leader has been interesting too. District councils have been fun. We have them every Tuesday so it's always fun to prepare for. Sundays are usually busy after church doing call in summary reports to the district and ZL's too...It's really made me kind of look out more for others which has been great.
The ward is doing well and I'm still just absolutely loving it here in Nungua!!! I'm so happy you's got that package! The post office I sent it from didnt look to friendly so I was a little hesitant, but all went though well! I'll be sure to bring a bunch of Kente ties and other things back home! Thats some tradition wear haha! Glad you's liked it!
Im looking forward to this upcoming week though! Alot of work to be done and I've really just been doing my best to focus my efforts and everything on others! I came across a talk from David.A.Bednar on the "character of Christ" and I loved it too much! It was alot about how Christ looks out and how we having the "natural man" look inwards to ourselves. As we look outwards, forget about ourselves our own personal worries, stresses, and problems seem to just go away! Something that I've really been experiencing over these last few weeks! I'm so grateful for my Saviors example and I strive to follow him more wholly everyday! It's a process for sure, but in turn very rewarding!
I hope you have a great week though Mom and Dad! All is well in Nungua! Love yous!
Elder Fesolai
Monday 28th March 2016
Hey Mom and Dad,
So This week has been quite an interesting one! Where to begin?
So Tuesday and Wednesday Elder Madsen and I have been in and out of the hospital, patiently waiting for results and particular doctors to see. It sure was interesting. Elder Madsen and I kept ourselves entertained though! We were able to talk to a few people waiting around about the church and Gospel which was kinda fun.
Tuesday morning we made it too District Council though, Elder Onyeugbo was transferred and so was Elder Nissinen. So it was a great meeting to have in the morning, We went and got pizza afterwards, kind of a tradition when someone leaves Nungua!
Wednesday we were with the Area Office doctor though. We spent a day with him in the hospital and he took us back to his house in Accra whilst we waited for results and more testing Madsen had to do. He shouted us KFC though hahaha. mega enjoyment!
However from Thursday on I have had no companion which has been a really interesting experience. Definately not the most enjoyable for sure, but It has been okay! Elder Madsen was picked up by the AP's to go to the mission home so since then I have worked with one of the members who just returned home from his mission, Sammy Boateng! Shouts out to that guy, he is great! It has been okay though.
On Sunday all the members were really confused and I was bombarded with the same question, where is your companion haha...I know us missionaries are never alone though! I have definately felt the presence of my Savior and the Spirit over the last few days. It was kind of stressful as I didnt have alot of time to proselyte in my own area since I was working in a group of 3 with the missionaries in the other ward. But I felt comforted!
This Easter has been interesting though! It really isnt celebrated here too much! Coincidentally the spirit was so strong as the members in Nungua ward 1 sung I know that my Redeemer Lives in Sacrament! Over the weekend I hope we all remembered the Savior and his great Atonement! I know that he atoned for everyone of us, and that he has risen again! It is so great to be able to serve him here in Ghana!
It was great to close the day at church with a Baptism. One of our investigators Joel was baptised after church! He asked me to baptise him aswell, so It was another awesome opportunity and experience! I've really been blessed with many opportunities thus far in Nungua! The work sure is paying off.
I hope you guys had a good Easter though! We had a massive FM at a members house SAturday night! She fed us 3 elders sooooo much Banku haha! It is safe to say we enjoyed plenty! Hope you's have a wonderful week though Mom and Dad!
I get a new companion tomorrow, so I'll see who it is then! Nungua is going great, I've been well too. It's getting really hot nowadays though! It's kinda nice!
Anyway, love yous! Till next week!
Elder Fesolai
May 2017


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- Casa
- Publicaciones
- Informes
- Detail
The workshop on "Emerging Concerns of Fishing Communities: Issues of Labour, Trade, Gender, Disaster Preparedness, Biodiversity and Responsible Fisheries", 04 to 06 July 2006, was held in SESC, Fortaleza, Brazil. The workshop was co-hosted by the NGO Instituto Terramar. The document gives a detailed report of the presentations and discussions transpired in the workshop. It is also worth noting that the discussions at the workshop as well as the issues identified, fed directly into ICSF's General Body meeting that followed the workshop and the process of identifying ICSF's own priorities for the coming period.

subset: commoncrawl


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Tuesday, October 26, 2004
My house circa 1912...
Click on this one to see a bigger view.
Howard Vasold gave me a copy of this photo taken of 'my house' around June 1912. The original house was actually built around 1858. When we moved here in summer 1960, there was an outhouse about where the fellow is sitting on what looks like the top of a building... the same outhouse? I don't know! Howard says the water was within 15 feet of the kitchen... toward the barn. They had to bring their milk over in a boat for two days!
Today Howard showed me a list he is keeping on his computer... of residents along the river and their ages at time of death. Well, many of them are actually still alive... at the age of 90 and older. One lady who lived along this river during the time of this photo is now 105 years old, still living in a nursing home!
The house? When the girls were small we remodeled the south end and added rooms to the north end. After they moved out we redid the south end again because the foundation was crumbling. Matter of fact, we were remodeling (and using the downstairs for our bedroom) when we woke up with the Tittabawassee River literally at our feet.
...now about all that big bad boogey man chemical... dioxin... Gee maybe I'll still be around at the age of 105... if I don't get hit by a beer truck!
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"Why do you do this to yourself every year?" The voice, roughened from years of chain-smoking, blared through the receiver. "I'm not gonna to tell you what you want to hear."
Luke stared at the scrawny man wearing an orange jumpsuit tied at the waist, wife-beater covering his lack of chest. A black spider-web spun from the neck down to the shoulder, its creator dangling down on what a generous person would call a bicep. "New tattoo, I see, Jerry."
Jerry sneered through the partition separating them. "You want to waste your time with small talk? Fine." The sneer turned to leer. "How's your sister? Ooops, that's right…she's dead."
Casey walks to the subway after her shift at the restaurant, tired, but happy at the tips for the evening. Every little bit helps in her quest for a new car to match her shiny new license. A pair of feral eyes watches her…stalks her, waiting for the right moment to pounce. "Give me your cash, bitch."
Her eyes widen at the glint of metal in the dim street-light, and she realizes how alone she is at the moment. She hands over her earnings with shaky hands, her twinkling eyes dulled by terror. The monster, undaunted by her cooperation, slashes. Crimson flies as she slumps, her body pulling her death along to jut from her breast. Coward's steps echo as Jerry strides away, counting the stained bills in his hand.
Luke shook off the scenario he'd constructed and replayed thousands of times since that night. Lips quirked into the approximation of a smile. "Nice try, Jerry." He leaned back, stretching out the cord of the phone attached to the side panel. "In the past, that might have been enough to make me storm out of here."
"Guess you finally grew a pair, huh?" Jerry chuckled, a dry wheeze that turned into a wracking cough.
Luke waited, sure more was coming. Jerry didn't disappoint. The murderer put his hand to his forehead in a mock swoon. "Oh, my sister! Why? Why did you do it? Just tell me and I'll leave you alone forever! Please!" His face screwed up as if he were crying, whimpering sounds finishing the performance.
"Luke, you're giving this bastard too much power over you." Hurt traces a gleaming path down Sylvia's cheek. "It's been ten years! You can't keep doing this to yourself."
"Some things can't be forgotten." The words sound hollow, even to him. He thinks of all the nights spent wondering, the difficulties in connecting, and the patience of his girlfriend as she soothes him when the nightmares strike.
"No they can't, but that doesn't mean they can't be accepted." His eyes flare and she strokes his cheek. "Can you even think of Casey anymore without his face there? Do you really want him forever tied to your memory of her? Don't let that night take two lives away."
"Don't let it take our life together away," she whispers.
Luke stood to leave. "I didn't come here today to spar with you again, Jerry. I came to tell you, I'm done. You did it, and I accept that you won't ever tell me why. As far as I'm concerned, you're just a pathetic loser not man enough to own up to your actions."
"Hey! You can't talk-"
"Shut up. You're powerless, and I'm through with you." Luke hung up the phone, ignoring the panic in Jerry's eyes. Silent "Wait! I'll tell you, don't go!" bounced off the sound-proof glass in futile fury as Luke walked away.
"Luke!" Casey bounces into his room, hands behind her back and grinning so wide it looks painful. "Guess what I got?" she sings.
"A present for the awesomest big brother ever?" he says in the same sing-song voice.
Little sister annoyance flickers across her features, but the smile takes back over. "No, doofus." She pulls out a piece of small rectangular plastic with her picture on it. "I got my license!" she squeals.
He shakes his head in mock dismay. "Oh, God. Time to warn the neighbors."
She punches his arm. "Stupid." Her arms wrap around him and she pecks his cheek. "Thanks for teaching me."
"My pleasure." He chucks her under the chin. "You'll do great." Her grin warms as she floats out of the room. "Just watch out for mailboxes!"
"That was one time!"
The stars glittered like diamonds against a black velvet sky on the drive home. They reminded Luke of Casey's eyes.
"Love you, sis."
Word Count: 750
Speakeasy #144. The prompts this week: "Some things can't be forgotten" and the video below:
- Your post must be dated January 12, 2013, or later.
- Submissions must be 750 words or fewer.
- Submissions must be fiction or poetry.
- Your piece must include the following sentence ANYWHERE (except as the title): "Some things can't be forgotten."
- The Speakeasy is for submissions written specifically for the grid. Please don't submit an entry if you intend to showcase it to another blog link-up. Such posts are deleted without notice.
- Please don't post long explanations before your post. We want your writing to be the star of the show. If you need to clarify anything, feel free to do so at the end.
- The badge for your speakeasy #144 post is found in the sidebar. Add the code to the html view of your post before publishing.
Head over and read some great writers take on the prompts. Join in as the challenge is open to anyone!
Hope you enjoy.
Happy Reading and Writing!
J. Milburn


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1. William Henshall m Margerie Gyll 2.. Thomas Henshall (?-c1631) m - Kendrick 3... John Henshall (1611-c1687) m Elizabeth - 4.... William Hinshaw (?-1699) m Elizabeth - 5..... John Hinshaw (c1660->1768) m Elizabeth Belshaw 6...... William Hinshaw (1724-1814) m Sarah Courtney (1730-c1768) 7....... Ezra Hinshaw (1753-1836) m Ruth Marshill (1759-1857) 8........ William Hinshaw (1779-1869) m Lorohame Beeson (1786-1839) 9......... Darius Hinshaw (1812-1900) m Nancy Ann Davis (1812-1890) 10.......... Oliver Edwin Hinshaw (1845-1927) m Martha Elder (c1858-?) 11........... James Edwin Hinshaw (1881-1954) m Minnie Ethel Redding (1884-1968) 12............ Worth Allen Hinshaw (1907-1975) m Virginia Bart Caudle (1904-1974) 13............. Michael Worth Hinshaw (1935-) m - Tombetlin 14.............. Michael Worth Hinshaw, Jr. (1967-) +Allison Holmes Clancy (1969-) 15............... Michael Worth Hinshaw, III 1 15............... Emily Robertson Hinshaw 1 15............... Eliza Ann Hinshaw (2003-) 2
|Michael Worth Hinshaw, Jr. [ID 17372]
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Born Nov 19 1967, Guilford County, North Carolina.3,4
He married Allison Holmes Clancy.1,2 Allison, daughter of John Franklin "Jack" Clancy & Paula Johnson, was born Jul 12 1969.1,5,6
Michael and Allison currently (2003) reside in Charlotte, North Carolina.1,6
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Tallinn Shipyard, placed at the mouth of the Gulf of Finland near to the crossroads of crowded trading routes, is ideally located for servicing the vessels calling to ports of the Baltic States, Russia, Finland and East coast of Sweden whose owners face no deviation cost prior to repairing in our shipyard. Tallinn Shipyard offers a wide range of services for all type of vessels allowed by combination of the skilled workforce and modern facilities. Tallinn Shipyard is a subsidiary of the industrial holding BLRT Grupp. There are two more shipyards in BLRT Grupp which are dedicated to ship repair and conversion services - Western Shiprepair in Lithuania and Turku Repair Yard in Finland.more
Number of employees180
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Irina Kostina
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Arctech has a long history and experience in building arctic vessels. Helsinki Shipyard was established in 1865 and ever since more than 500 ships have been built in the same location.The shipyard has delivered about 60 percent of the icebreakers in operation around the world. Although we have a lon ...
MEYER TURKU OY, family-owned by Meyer Werft, is one of the leading European shipbuilding companies. Turku Shipyard was founded in 1737 and, today, the managing partner of the company is Dr. Jan Meyer. The company provides state-of-the-art technology solutions, advanced construction processes and cu ...
Established in 1989, Turku Repair Yard Ltd continues the long tradition of Finnish ship repairs. Presently the company employs 70 persons and, depending on the work load, an additional 250-300 persons from our local partner companies. Turku Repair Yard Ltd takes the quality of its services serious ...
Riga Shipyard is one of the largest yards in the Baltic region repairing more than 100 seagoing vessels per year and has built more than 150 hulls, some partially outfitted, since 1997. Established in 1913 and having more than a century old history, today we continue to serve our European and Scand ...


text:
The long-term effects of head injuries among football players has been the topic of growing concern in recent years, including whether Chronic Traumatic Encephalopathy (CTE) – a devastating and deadly brain disease– occurs more often among football players. In July, the Journal of the American Medical Association reported that a recent study of brains donated for research diagnosed CTE in 99 percent of those of 111 former NFL players.
"Three-quarters of fans say head injuries in football are a major problem and another six in 10 are worried about off-field violence involving players. Despite that, football remains America's favorite professional sport," according to a press release that summarized the results of a UMass Lowell-Washington Post Poll that was released this past September.
While many people are concerned and even believe that the science is settled that the game is damaging and dangerous, there are powerful forces that are pushing the continued popularity of the sport, and we have not yet hit that breaking point.
GMP Sports spoke to Prof. Joshua Dyck, co-director of UMass Lowell's Center for Public Opinion, who worked on the poll, to glean further insights into the issue. He and his colleagues did this poll to try and understand what was going on with football fans, because "we are starting to become more and more aware that this game is really really dangerous and has some potentially huge lifelong implications for the people who play it and the families who end up caring for them, but at the same time we are connected to football as this social and cultural experience, which puts us in a very uncomfortable place right now…What is the breaking point? And what we found in the survey is that we haven't hit it yet."
First, a few data points and takeaways from the Poll:
- "The survey of 1,000 Americans finds 77 percent of those who consider themselves professional football fans said that head injuries causing long-term health issues for players are a major problem, compared with only 15 percent who said it is a minor problem and 6 percent who do not consider it a problem."
- "An overwhelming majority of Americans polled believe that there is settled science that playing football causes brain injuries, with a total of 83 percent who say that is either certainly (45 percent) or probably (37 percent true). Only one in 10 say that is probably false (7 percent) or certainly false (3 percent). A majority also said that it is certainly true (52 percent) that CTE is a serious public health issue and another 28 percent said it is probably true. Only one in 10 said it is probably (7 percent) or certainly (3 percent) false."
- "The poll also found that sports fans see other issues with football, including domestic violence (61 percent) and violence in general (60 percent) committed by players as major problems."
- "Despite this, 60 percent of Americans say they are fans of professional football, with 31 percent identifying themselves as "big fans," the poll found. Major League Baseball and the National Basketball Association were the second-most popular among professional sports at 45 percent and 39 percent, respectively, followed by boxing (28 percent); mixed martial arts (25 percent); auto racing and soccer (both at 24 percent); ice hockey (22 percent); and WWE wrestling (14 percent)."
- Despite the serious controversies facing pro football in the last few years, there has been little impact on its popularity, as just as many Americans are fans today as in 2012, according to this Poll. Specifically, "the UMass Lowell-Washington Post poll found that interest in the sport increased over the last few years among 23 percent of football fans and decreased among 19 percent. Twenty-five percent of female fans said their interest has increased, compared to 12 percent who reported a decrease. Among male fans, 25 percent reported a decrease in interest and 21 percent said it increased. Interest grew 34 percent among fans who are ages 18 to 39 while interest showed a small net decrease among fans age 40 and older."
- Notably, "the most common reason that fans reported for a decrease in interest in the NFL in recent years was not concussions or violence, but political issues. Of those who identified that reason, 17 percent pointed to protests during the national anthem by players such as Colin Kaepernick. Ten percent cited too many penalties and game delays or a decline in their interest in sports in general and 8 percent said they are too busy. Only 7 percent cited too many injuries or too much violence in the game."
- "The major reasons fans say they watch pro football point to the geographic, social and familial ties that bond them: 71 percent cited rooting for a favorite team and 53 percent cited enjoying time with friends and family. The game's action also scored high among football fans, with 68 percent saying it is a major reason they watch, but the hard-hitting nature of the game was a major reason to watch among only 26 percent."
Commenting on the poll, Dr. Dyck noted that "There is a growing ambivalence among pro football fans that puts their love of the game in conflict with their views on concussions and head injuries. The survey indicates that football fans are very concerned about the problems related to concussions and half think the league has not done enough to address the issue. However, there is no evidence in this survey that NFL fans have started voting with their feet and remote controls by turning away and tuning out."
"One of the more interesting findings in the survey is that many of the reasons Americans are drawn to football are not because of hard hits, but rather for social reasons – rooting for a specific team, and spending time with friends and family. The experience of watching football transcends the game itself and is deeply ingrained as a part of American culture," said Dyck.
Indeed, what makes change so hard – even in the face of our knowledge of how dangerous the sport is – is the social and cultural experience of football. Those polled did not focus on 'big hits' as a reason of why they watch the game; people watch because that is how they spend time with family or friends or because of their rooting interest. These bounds are hard to break and make people more willing to accept changes to football to make it "more safe," rather than abandon football completely. True change will require a huge social and cultural shift.
We also asked Dyck about the battle going on in terms of "the science" – where we have witnessed political and monied interests sowing doubt as to the science behind CTE and its relationship to tackle football. Interestingly, his study found that despite all of this, most Americans believe that the science is settled.
Dyck, who is himself a political scientist, raised the question of where we go from here:
"Does this becomes a political issue like climate change, or does this become an issue where science and popular opinion overtakes everything, like smoking?"
That remains an open question. "I don't know where we are going to be in 20 years, but I do know the issues aren't going away," said Dyck.
One obvious next question for Dr. Dyck is to take a hard look at youth football. How do we feel about football in connection with parenting? A more recent Poll at Umass Lowell focused specifically on youth football and concluded that a majority of Americans feel that tackle football is unsafe for young kids.
Some of the highlights of that study are:
- "Fifty-three percent of adults surveyed feel that tackle football is not a safe activity for kids before they are in high school; 41 percent feel it is safe before high school."
- "Despite their opposition to tackle football before high school, a 57 percent majority of Americans believe that high school football is a safe activity."
- "Among those polled who said that it is true that playing football causes brain injuries, 44 percent said it is okay for children 13 or younger to play football. Among those who did not agree that playing football causes brain injuries, 54 percent said it is okay for children age 13 and younger to play football."
"As Americans become more aware of the long-term effects of head injuries and concussions in sports, their preferences about youth football reflect a public divided about whether the game continues to be a safe activity for children," said Prof. Joshua Dyck, co-director of UMass Lowell's Center for Public Opinion. "The data also shows that fans of football and other sports are still largely supportive of children ages 10 and up participating in tackle football, but these views are not shared broadly across the American public."
Looking back at both studies, Dr. Dyck wonders if there will be a point in time when people can perhaps rationalize watching pro football – because of the money they are being paid, the personal choice the athletes are making, or some of the safety measures they are taking – but still not want their own kids to play this game.
According to these polling results, we are not yet there. It remains unclear how and whether the paradox of knowing how harmful football is and yet loving football will be resolved.
Credit: Associated Press


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Slim-Fit Plus-Size Graphic Ringer Tee
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Cellule d'innovation Communautaire :: Your first category :: Your first classifieds section
Your first classified
Mise en ligne le Jeu Déc 27, 2018 11:04 am
Description :
This is an example of an ad on your forum.
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Getty Trust Receives $5M Gift for Global Conservation
The J. Paul Getty Trust today announced a $5 million gift from philanthropists John E. Bryson and Louise Henry Bryson to establish a new fund supporting the global work of Getty Conservation Institute.
The Brysons are longtime Getty supporters. A former chief executive of Edison International, John Bryson served as U.S. Commerce secretary under President Barack Obama and was a member of the United Nations Secretary-General's Advisory Group on Energy and Climate Change. Louise Bryson has had a 34-year-career in media, holding executive positions at Lifetime Television, Lifetime Movies, and FX network.
"We are pleased to this gift to allow the GCI to pursue its conservation work in world where cultural heritage is increasingly at risk," Louise Bryson said in a statement.
"(W)e simply can't do everything we'd like to do without significant gifts like this one from the Brysons," Getty President and Chief Executive James Cuno said in the statement.
In recognition of the gift, the title position of director of the Conservation Institute will be renamed as the John E. and Louise Bryson Director, Getty Conservation Institute. This is the Getty's first named directorship.
"John and Louise's remarkable gift will extend the reach of this Institute in ways that we had not imagined," said Institute Director Tim Whalen, who will hold the new title. "They understand the importance of what we do and its connection to advancing civil society."
Media and entertainment reporter Diane Haithman can be reached at email@example.com. Follow her on Twitter @dhaithman.
For reprint and licensing requests for this article, CLICK HERE.
Stories You May Also Be Interested In
- J. Paul Getty Trust's Founding President, Harold M. Williams, Dies at 89
- Los Angeles Chamber Orchestra Gets Largest Gift in History
- Auto Brand Genesis Gives $500,000 to J. Paul Getty Museum
- Steve Bannon Returns to Brentwood's Breitbart News
- Broad Museum to Unveil Public Artwork for Pacific Standard Time: LA/LA
- Colburn School Receives $1 Million Bequest from Iona Benson
- Billionaire Philanthropist Eli Broad Announces Retirement
- L.A.'s MarketCast Acquires Fizziology


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There are as plenty of different ways to eat an all raw or high raw diet as really are a few people. Easiest approach may be the Natural Hygiene way. One Natural Hygiene approach, there aren't any recipes, as well any machinery; You just eat food as referring from nature. There is a lot to be said on that easy to recognise approach, the majority of period it is how I in real time.
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The most energizing associated with soapcrafting expertise is developing new cleansers. I love the initial inspiration of a new concept, like when I decided to develop a soap based on the sacred Hindu syllable Om (or Aum). When intoned, Om connects our deepest self on the All, the world-soul, introduced home versions wanted to craft a soap that is both uplifting and grounding. I also wanted to craft a soap made use of appeal to both both males and females. So I first formulated a base recipe that included sunflower oil (light) and P ISO Hemp Oil (earthy), then blended sweet orange petrol for joy, mandarin cooking oil to elevate the spirit, and cedar essential oil for opening spiritual channels, and also as a grounding bottom note.
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Huisheng Group Co.,Ltd. is called Zhongtian Paper Joint Stock Co., Ltd. before, which is the biggest manufacturer of core board and one of top 100 paper mill in China, with 60 million USD of total capital and 750 staff . ...
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SEASON 2018 — Update!
St. John's Grace Kingdom Crew are 2018 Church Runners-up!
On Sunday July 8th, our Kingdom Crew Softball Team was not successful in it's pursuit of it's fourth League Championship.
Our team was defeated 19-10 by the Baltimore Bandits.
Nevertheless, fun and fellowship was enjoyed by all – players and fans alike!
See you next year!
Standing: Jason Russ, Patrick Spliedth, Dave Wieland, Steve Lauer, Coach, Greg Hewitt, Jeff Reinhardt, Tim Faircloth
Middle: Matt Kruger, Rory Reinhardt, Bat Boy
Kneeling: Pete DeLuca, John Camonayan, Christina Spliedth, Morgan Bunting, Danielle Kruger, Tyler Rubalcaba. Natasha Kruger
Not Shown: Darby Adams, Tyler Smith
St. John's Grace Kingdom Crew are 2017 Church League Champs!
Back Row—Greg Hewitt, Matt Kruger, Patrick Spliedt, Joe Healy, Dave Wieland, Brad Oberholzer, Steve Lauer, Coach.
Front Row—Tyler Rubalcaba, Natasha Pierce, Danielle Kruger, Morgan Bunting, Pete DeLuca, Christina Spliedt and John Camoneyen.
Not shown are Jeffrey Rienhardt and Jason Russ.
Plan to support the team next season!
All games are played on Dickey Field in Oella: From Rolling Road (at the Senior Center) turn west onto Old Frederick Road. Turn Right onto Rockwell Avenue. Rockwell Avenue dead-ends at Westchester Avenue. Turn Left onto Westchester Avenue. Turn Right onto Trinity Church property. Proceed to the rear lot (the softball field is to the right beyond the path).


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Cyrus Afrasiabi, M.D.; James L. Whitehouse, M.S.; Edwin M. Knights Jr., M.D., F.A.C.P.
This content is PDF only. Please click on the PDF icon to access.
A new, highly sensitive liver function test has been developed to aid the clinical laboratory in providing information for the physician for the evaluation of the status of the liver. This test is based on measurement of serum guanase. Guanase, which participates in purine metabolism, is present in high concentration in the liver, but normally only negligible amounts can be found in the blood; thus it can provide an indication of the extent of liver cell damage by its concentration in serum of plasma.
To be practical as a liver function test, a procedure must be easily performed by the
Afrasiabi C, Whitehouse JL, Knights EM. Clinical Applications of Serum Guanase Determinations.. Ann Intern Med. 1965;63:909. doi: https://doi.org/10.7326/0003-4819-63-5-909_3
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Published: Ann Intern Med. 1965;63(5):909.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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The Insider Picks team writes about stuff we think you'll like. Business Insider has affiliate partnerships, so we get a share of the revenue from your purchase.
Moving is a stressful experience no matter how you slice it, and taking on the job of finding and outfitting your first apartment as an adult is even more so.
Your first apartment is a perfect storm: an intersection of many needs and low resources. Chances are high that your college roommate might have bought the kitchen utensils... or the vacuum... or the pots and pans... and now you're trying to furnish an entire apartment on your own with less money than it seems the job will demand.
The few purchases you do make will need to last you longer than the cheap, seasonal models you bought in college so you're not in the same spot, dumping more money into a dresser next year. You'll likely want nicer belongings than plastic storage bins for all of your clothes as an adult now, anyway.
Since it's unlikely you have a carte blanche at West Elm, the purchases you do make are best when backed up by the advice of people who've been there before and can help you choose wisely. While I went through my post-graduation apartment search recently, I decided to make use of an incredible resource and survey my colleagues on their most valuable first apartment purchases. We spend around 40 hours a week thinking of ways to optimize peoples' lives with valuable products, so the purchases we make for our own homes carry special significance for me.
Below, you'll find the 17 things the Insider Picks team is most glad we bought for our first apartment.
Breton Fischetti, senior director of commerce: Brooklinen sheets
This pick is one that I did with a bit of hindsight, but I lived in a four-bedroom apartment, so my bedroom was the only bit of space in the apartment that was truly mine.
I really enjoyed having a good set of sheets. Once I got them it really made a difference in making the place feel more grownup and put together compared to whatever sheets I had leftover from high school/college. I recently bought a set of Brooklinen sheets and they are a great option. It's definitely a stretch of a purchase for a first apartment, but you use sheets every day so it's worthwhile.
Brooklinen Luxe Hardcore Sheet Bundle (Queen), $239.25
A mirror to open up a small room
A first apartment or home is probably going to be smaller, and the easiest way to make a small space feel bigger is with a good mirror. It reflects light and adds depth to any room.
Umbra Mira Wall Mirror, $80
Ellen Hoffman, commerce editor: OXO Mixing Bowl and Colander Set
I bought this set of mixing bowls and colanders when I moved into my first apartment, and years later it's up there with my tea kettle and cow mug for most-used items in my kitchen.
The set includes three mixing bowls and three colanders in various sizes with a space-saving, nesting design. So simple, but so practical for anyone who cooks at home a lot.
OXO Good Grips Nesting Bowls and Colanders Set, $64.38
Le Creuset Whistling Tea Kettle
This is something my mom got me when I moved into my first apartment after college, and I still use it every day — sometimes multiple times a day. As a result of having such a good experience with the tea kettle, I've since bought other Le Creuset pieces (this cast iron Dutch oven and skillet) as I've had the extra money to spend rounding out and upgrading my kitchen.
Le Creuset Whistling Tea Kettle, 1.8-Qt., $100
Velvet hangers
I ditched all the plastic and wire hangers I had almost immediately after graduating college. Having a matching set of hangers goes a long way toward elevating the overall look of your closet and keeping everything organized…and actually ON a hanger. It's a super cheap upgrade to make right off the bat.
AmazonBasics Velvet Suit Hangers (50 Pack), $20
A nice area rug
I wasn't able to afford a lot of nice things for my first apartment. I had to be very discerning about the more expensive purchases I made. A nice area rug was one that made the cut.
A nice area rug can instantly pull a living room or bedroom together, and it's something you should have for many years to come as long as you take care of it. I got my first nice rug from CB2 and it moved with me this past March to my new place. I rent a vacuum cleaner from Home Depot every year or so to keep it looking its best.
Similar: West Elm Arrow Channels Shag Dhurrie Rug (5'x8'), $299
Malarie Gokey, guides editor: a makeup organizer
When you have a small apartment, cabinet space is hard to come by. After years of using mugs and other random containers to organize all my lotions, makeup, brushes, and so on; I finally caved and bought a makeup organizer that's small enough to fit in my bathroom cabinet. It organizes all my stuff so that it takes up less space than before and it makes finding what I need easier — especially when I'm bleary-eyed in the morning.
MelodySusie Acrylic Jewelry and Cosmetic Storage Organizer, $30.99
Candlestick holders
My grandmother was from Sweden, and she always had a thing for candles. It turns out that loving candlelight isn't just a Swedish tradition, it's a family tradition. After scouring antique shops for a solid brass candlestick holder, I finally found a lovely one and bought it. Now, I light candles every night at dinner. It's amazing how therapeutic, romantic, and relaxing candlelight is after a long day.
Refinement House Brass Candle Holders, $12
Note: currently unavailable
Brandt Ranj, associate commerce editor: A surge protector
If you've taken the time to accumulate some nice electronics, do yourself a favor and plug them into a surge protector. Apartments and outlets vary in quality, and one wrong move could leave your computer, TV, or game console totally fried. It's happened to me before, and it's not fun. The first thing I did when I moved into my new place was plug in two of Belkin's surge protectors, and I haven't had any trouble since.
Kelsey Mulvey, commerce reporter: Lightweight, linen curtains
There are some things everyone should add to their decor wish list, like these linen curtains from West Elm. The lightweight linen makes my studio look larger and lets just the right amount of sunlight through, but still gives me and my home some privacy. I bought them nearly three years ago and still love them.
West Elm Sheer Linen Curtain, $27.99-$55.99
Note: currently unavailable
A scarecrow
There's a reason I still live in my first apartment. My studio has tons of closet space, is close to several subway lines, and even has a small balcony of its own. The one thing I can't stand about my apartment? The uninvited pigeons that perch on my balcony. I bought an owl scarecrow about a year ago and am pleased to report my balcony has been pigeon-free ever since. Thanks to the bobblehead design, its lifelike movements are supposed to scare any unwanted critters away.
Make no mistake this scarecrow occasionally gives me the creeps, but if you have outdoor space, I'd highly recommend picking up one.
Gardeneer by Dalen Natural Enemy Scarecrow Rotating Head Owl, $18.70
Tyler Lauletta, commerce reporter: A framing service
When moving into your first apartment, one of the most adult moves you can make is to frame your posters. Ideally, by this point you are past your Bob Marley and Reservoir Dogs phase, but if you have a poster you love and would like to display, send it to Framebridge and turn it into an art piece worthy of your new abode.
If you are having trouble decorating your place, Framebridge can take photos straight from your Instagram account and turn them into hangable art. It's a simple solution to making your apartment a little more your own, and a tip I wish I had had when I moved into my first apartment.
Get started with Framebridge here
Mara Leighton, commerce intern: A necklace holder
I own a lot of necklaces and other jewelry, but I find myself perpetually wearing the same ones by default. I keep every one that I own arranged on a decorative plate, but that has made them easy to ignore and options hard to visualize. Since the purpose of jewelry is to wear it, I've recently invested in a necklace holder that helps me see what I'm working with and can double as a shelf for my perfumes and a nice succulent plant, too.
The Knotted Wood Wall Necklace Holder, $45
The Sonos Play:1
I like to fall asleep with music, but I don't want to ruin my hearing with earbuds or have them fall out and miss my phone alarm in the morning. In college, missing class every once in awhile is fine, but missing work is not.
The Play:1 is a great, multi-use speaker that customizes its sound to the dimensions of the room you set it in, and it also functions as a way more effective alarm than my phone. I listen to music on it with a sleep timer at night and bring it to the living room whenever I plan to have guests over. It's not so expensive where quality speakers are concerned, and it's small enough to fit basically anywhere. This was a great value buy for me. If you'd like to know more, you can read my full review here.
Sonos Play:1 Wireless Smart Speaker, $149
A shoe organizer
Just by virtue of living in a city that has four temperamental seasons, I definitely own too many shoes. They're usually the hardest item to find a convenient spot for in my room, no matter where I live. Horizontal organizers take up space I don't have, and having them sitting outside my closet makes my room feel unfinished to me. This over-the-door shoe rack has been a lifesaver since I can declutter my room and see all my options at once. Plus, this shoe rack doesn't utilize pockets like other options, so even my heels and boots can fit.
Whitmor Over-The-Door Shoe Rack, 36-Pair, $23.94
A writing desk
When I'm working at home for the day or want to begin something creative, I need a spot that takes me out of my comfort zone more than laying in my bed can. For this reason, I like to keep a hard-backed chair and a writing desk in my room so I don't need to go too far in order to concentrate.
I don't have much room to give, but little personal desks are inexpensive and get the job done. There are even less expensive options out there, but my room is the only space that's truly mine in a shared apartment, so I'm willing to spend a little more on the things I need to feel truly at home there.
Alaterre Shaker Cottage Writing Desk with Drawer, $170.93
An inexpensive cooking essentials kit
I spoke from experience when I said that your roommates may have gotten the utensils, and now you're stuck trying to furnish a home with the good luxuries like nice sheets and well as the less glamorous necessities like spoons and forks. This was an easy (and thankfully cheap) way to kill a bunch of birds with one stone.
Wahilulu Premium Kitchen Utensils Set, $24.49
If you want to see more from Insider Picks, we're collecting emails for an upcoming newsletter. You'll be the first to hear about the stuff we cover. Click here to sign up .
Disclosure: This post is brought to you by Business Insider's Insider Picks team. We aim to highlight products and services you might find interesting, and if you buy them, we get a small share of the revenue from the sale from our commerce partners. We frequently receive products free of charge from manufacturers to test. This does not drive our decision as to whether or not a product is featured or recommended. We operate independently from our advertising sales team. We welcome your feedback. Have something you think we should know about? Email us at firstname.lastname@example.com.


text:
Meet Amanda. She is a Physician Assistant with Northern Arizona Orthopaedics and cares for patients in the Hand Center, inside the Summit Center. Amanda has a deep and wide breadth of knowledge surrounding the specialty of Hand and Upper Extremity care and appreciates helping treat patients as though they are family. We thought it would be fun to learn a little more about this exceptional and compassionate NAO provider!
HOMETOWN? Flagstaff! Born and raised!
BUCKET LIST ITEM? To attend cooking school in Italy
FAVORITE QUOTE? "But still, like air, I'll rise. – Maya Angelou
IF YOU COULD MEED ANYONE? My Great-Grandma Frances, she was my moms' favorite and I'm named after her.
WHEN YOU'RE NOT WORKING? I'm leading Girl Scouts, being a proud mom, playing volleyball, skiing, snowboarding, playing volleyball, hiking, biking, gardening, camping, rafting, painting, mushroom hunting, crafting, restoring furniture, antiquing, or traveling.
DREAM VACATION? Bora Bora
WHAT IS SOMETHING ABOUT YOU MOST DON'T KNOW? I have two dwarf goats who like to jump on the trampoline.
CARE PHILOSOPHY AT NAO? I treat people like I would like to be treated. Whether I'm giving an injection, putting on a cast or recommending a surgery, I try to put myself in my patients' shoes and do what I would want done for myself. This helps me give everyone the best care possible!
To read Amanda's professional biography, click here.


text:
Eco Hotel El Rey del Caribe guide
| Eco Hotel El Rey del Caribe photos
Eco Hotel El Rey del Caribe, Cancún, Yucatán Peninsula, Mexico
by massimo Medros
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All MAs 13 types MULTIPURPOSE TOOL
"All MAs-13 jm" is a tool that allows accessing from a single control box 13 different types of MAs: 9 standard MAs in MetaTrader 5 (SMA, EMA, SMMA, LWMA, DEMA, TEMA, Frama, VIDYA, AMA ) and 4 non-standard (LRMA, HMA, JMA, SAYS) copyrights to which belong to Nikolay Kositsin (Godzilla), they can be found on the web (e.g. LRMA).
General Parameters
- Period MA: the number of bars to calculate the moving average.
- MA Method: select the type of moving average to show in the current graph.
- Applied Price: select price type (close, high, low, etc.).
- TimeFrame: provides the vision of MA in different frames to the graph.
- Manual trader: it has a "multipurpose knife", more versatile than the standard indicators, which facilitates analysis of trends from a single control box and different timeframes of the chart, without having to find at the "navigator" each type of indicator.
- Automatic trader: Allows you to optimize the type of MA as another parameter of the EA by simply including "Method MA" as external parameter. A strategy can not work with EMA but be profitable with VIDYA or AMA, as well tells the author's experience. By giving value to parameter to take into account the following enumeration: {SMA=0, EMA=1, SMMA=2, LWMA=3, DEMA=4, TEMA=5, FRAMA=6, VIDYA=7, AMA=8, LRMA=9, HMA=10, JMA=11, AFIRMA=12};
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Publications and Research
Document Type
Publication Date
Spring 4-2-2017
Retinal dysfunction is often caused by aberrant neural cell migration during development. In this study, we observed the migration of neural cells of the Drosophila melanogaster after marking cells of the 3rd instar larvae with the GAL4-UAS expression system when exposed to a concentration gradient of FGF-8 through the use of a microfluidic device. The glial and neuronal cell ratio in the developing brain was determined through immunofluorescent staining and observation. In future studies, a microfluidic device that mimics the developing Drosophila brain and retina will be designed in order to better understand the biological factors that affect the migration and differentiation of the cells.
Recommended Citation
Beck C, Singh T, Farooqi A, Venkatesh T, Vazquez M., 'Controlled microfluidics to examine growth-factor induced migration of neural progenitors in the Drosophila visual system,' J Neurosci Methods. 2015 Dec 29;262:32-40.
Included in
Biomedical Engineering and Bioengineering Commons, Cell and Developmental Biology Commons


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"Music is what connects us directly with the rest of the Cosmos,"
A Brief History of the Universal Art-Form — Music
What is the Actual Function of Music in Human Life?
Have you ever pondered the role that music plays in how a human being is shaped and formed throughout his/her life? On the surface, this seems like such a basic line of inquiry. A hundred years ago or more, before the advent of recorded music, this question of the central role of music in human life would have had far more import.
Back in those days, music was always an event, being performed and shared in real time, as opposed to our most common interaction with music in our present age — that of listening to recorded reproductions on headphones, in our automobiles, or most commonly, in a retail environment while we are shopping.
Thanks to the technological advances of the past century — namely, the means of recording music and then broadcasting it via radio, television, and more recently, handheld computerized devices connected to the internet — music has become truly ubiquitous. There are immense positives and negatives to this current state of affairs — as the following paragraphs will attest.
A little over 25 centuries ago, the Greeks, directly inspired by the insights of the Egyptians (who had been exploring and examining the central role of music as a powerful force of healing and longevity for 2000 years before the Greeks, and more specifically, Pythagoras, shared these insights with the world in the 5th century BC) placed Music at the top of a list of daily habits that ensured for living an optimal life.
Music was considered as important to health and development as physical nourishment and exercise, as indispensable to intellectual and moral development as mathematics, history, philosophy, and ethics, and as vital to social harmonization as well-functioning economy and community life.
If the Ancient Greeks were provided with a future window on the way that humans in the 21st Century have relegated music to mere entertainment and the teaching of music in schools as mostly an elective (an afterthought), they would be absolutely appalled.
"Music is what connects us directly with the rest of the Cosmos," said Pythagoras.
A century and a half later, Aristotle would write about the health-conferring effects of certain musical tones and the optimization of human endeavor through the active cultivation of specific tonal intervals.
Music shaped the surrounding environment as much as it shaped the developing human being, and thus should be treated as nourishment, according to Aristotle's mentor, Plato.
In other words, music was not a luxury or a past-time. It was central to living an optimal life.
In our Music History class this year at Almondale Academy, we will explore several concrete strategies for making Music more central to our lives and hopefully help to "un-do" the way it has been trivialized in our current society. Wish me luck. We have our work cut out for us
By Matthew Hammond


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In 2017 only one number mattered: 73. That's how many votes we lost by in the race to represent the 28th district.
We didn't lose though. We won. We proved everyone wrong. We started the race with no party support and finished it with only 1/3 of the resources of our opponent. And yet, we held our own in one of the toughest races in the state.
This year we can win. But we need YOUR help.
This is about the ground game. Whether you have a few hours, a whole day, or just your lunch break, you can help elect send Josh to the House of Delegates. Contact us to get involved!
Stay Informed
Stay up-to-date on news, events, and other key campaign announcements by subscribing to our newsletter.
Running a successful campaign requires resources. We put up a tough fight with a shoestring budget in 2017, so imagine what we can do with just a bit more support this year.
Your generous donation will help ensure that we have the funds needed to flip the district this year.


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A Study of TAS-120 in Patients With Advanced Solid Tumors
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT02052778
Recruitment Status : Recruiting
First Posted : February 3, 2014
Last Update Posted : July 2, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
This is an open-label, nonrandomized, Phase 1 dose-escalation, dose-expansion, and Phase 2 study targeting tumors with FGF/FGFR aberrations. The purpose of the study is to evaluate the safety, tolerability, PK, pharmacodynamic, and anti-tumor activity of TAS-120 in patients with advanced solid tumors with and without FGF/FGFR-related abnormalities.
The study will be conducted in 3 parts, (1) Dose escalation to determine the MTD and/ or RP2D of TAS-120 in which this part of the study has been completed; (2) Phase 1 expansion to further evaluate the safety and efficacy of RP2D of TAS-120 in patients with tumors harboring specific FGFR aberrations, specifically in patients with cholangiocarcinoma, gliomas , urothelial carcinomas and any other tumors with FGFR fusion or activating mutation or amplification. Up to approximately 185 patients will be enrolled in the phase 1 expansion; and (3) Phase 2 study to confirm ORR of TAS-120 in intra-hepatic CCA patients with tumors harboring FGFR2 gene fusions. Approx. 100 patients will be enrolled in phase 2.
|Condition or disease
|Cholangiocarcinoma Brain Tumor Urothelial Cancer Other Tumor Types With FGFR2 Gene Fusions Activating Mutations FGFR2 Amplification
|Drug: TAS-120
|Phase 1 Phase 2
Phase 1 Dose Escalation Phase 1 Dose Escalation has been completed as of Dec 2017
Phase 1 Dose Expansion: (CLOSED)
Up to approximately 185 patients will be enrolled among the 8 groups as outlined below:
- Group 1- CCA (iCCA or eCCA) with FGFR2 gene fusions.
- Group 2- CCA (iCCA or eCCA) with FGFR2 gene fusions that are chemotherapy naive or intolerant to first line chemotherapy (i.e., on chemotherapy regimen ≤ 1 cycle).
- Group 3 - CCA (iCCA or eCCA) with FGFR2 gene fusions treated with prior FGFR inhibitors.
- Group 4 - CCA (iCCA or eCCA) with other FGFR2 abnormalities, ie, gene mutations, rearrangements or amplifications.
- Group 5 - GBM or grade III glioma (i.e, anaplastic astrocytoma or anaplastic oliogodendroglioma) with FGFR gene fusions or activating mutations
- Group 6 - Advanced urothelial carcinoma with FGFR3 fusions or FGFR3 activating mutations.
- Group 7: Basket of tumor types with tumors harboring FGFR2 amplification (≥10 copies).
- Group 8 - Basket of tumor types (except CCA, brain tumors and advanced urothelial carcinomas) with tumors harboring FGFR gene fusions or activating mutations.
Phase 2:
Approximately 100 iCCA patients with confirmed FGFR2 gene fusions will be treated. Patients will be centrally screened for FGFR2 gene fusions. This is a Single arm study with the primary endpoint of ORR.
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|371 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Phase 1/2 Study of TAS-120 in Patients With Advanced Solid Tumors Harboring FGF/FGFR Aberrations
|Study Start Date :
|July 2014
|Estimated Primary Completion Date :
|December 2019
|Estimated Study Completion Date :
|June 2020
Experimental: TAS-120
TAS-120 tablets, oral; 21-day cycle
Dose escalation portion of the study was completed.
Dose expansion- patients with tumors harboring specific FGFR aberrations, specifically in CCA, Brain Tumor , Urotherial carcinoma and any other tumors with FGFR fusion, activating mutation and amplification.
Phase 2- intra-hepatic CCA patients with tumors harboring FGFR2 gene fusions
Drug: TAS-120
- Phase 1 - Overall Response Rate (ORR) [ Time Frame: 12 months ]Response assessments will be made based on RECIST guidelines (version 1.1, 2009) for solid tumors
- Phase 1 - Early Progression Rate (EPR) for GBM or grade III glioma [ Time Frame: 12 months ]Response assessments will be made based RANO for brain tumors
- Phase 2 - Overall Response Rate (ORR) [ Time Frame: 12 months ]Response assessments will be made based on RECIST guidelines (version 1.1, 2009) for solid tumors
- Duration of Response (DOR) [ Time Frame: 12 months ]DOR is defined as time from first documentation of response to the first documentation of objective tumor progression or death due to any cause, whichever occurs first
- Disease Control Rate (DCR) [ Time Frame: 12 months ]DCR is defined as proportion of patients with objective evidence of complete response, partial response or stable disease
- Progression free survival (PFS) [ Time Frame: 12 months ]PFS is defined as time from the day of first dose to the date of first objectively documented disease progression or death
- Patient Reported Outcome (PRO) [ Time Frame: 12 months ]PCR is define as the analysis of EQ-5D and EORTC QLQ-C30 from baseline through end of treatment
- Overall Survival (OS) [ Time Frame: 12 months ]OS is defined as date of first dose to death date in the safety population of Phase 1 and safety and efficacy population for phase 2
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Has histologically or cytologically confirmed, locally advanced, metastatic cancer meeting the following criteria:
Phase 1 Expansion
- Patient has failed all standard therapies or standard therapy does not exist or is not tolerated.
Patient has specific FGF/FGFR aberrations
- Intrahepatic or extrahepatic cholangiocarcinoma with FGFR2 gene fusions or other FGFR2 abnormalities, i.e., gene mutations (see Appendix A), rearrangements or amplifications
- Glioblastoma or grade III glioma (i.e., anaplastic astrocytoma or anaplastic oligodendroglioma) with FGFR gene fusions or activating mutations.
- Advanced urothelial carcinoma with FGFR3 fusions or FGFR3 activating mutations
- All other tumor types harboring FGF9, FGF19 or FGFR2 amplifications (≥ 10 copies), FGFR gene fusions, or FGFR activating mutations
Phase 2
- Patient has histologically or cytologically confirmed, locally advanced, metastatic, unresectable iCCA harboring FGFR2 gene fusions based on results from a NGS assay by the Sponsor's designated central laboratory
- Patient has been treated with and failed at least one prior systemic gemcitabine and platinum-based chemotherapy for the advanced disease
- Must have documentation of radiographic progression of disease on prior systemic therapy
- Patient has measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) guidelines (version 1.1, 2009) for advanced solid tumors or RANO criteria (2010) for brain tumors.
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
- Adequate organ function
Exclusion Criteria:
A patient will be excluded from this study if any of the following criteria are met:
- History and/or current evidence of non-tumor related alteration of calcium-phosphorus homeostasis.
- History and/or current evidence of clinically significant ectopic mineralization/calcification.
- History and/or current evidence of clinically significant retinal disorder confirmed by retinal examination.
- A serious illness or medical condition(s)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02052778
|Contact: Jerry Huang, MD
Show 53 Study Locations
|Study Director:
|Jerry Huang, MD
|Taiho Oncology, Inc.
|Responsible Party:
|Taiho Oncology, Inc.
|ClinicalTrials.gov Identifier:
|NCT02052778 History of Changes
|Other Study ID Numbers:
2013-004810-16 ( EudraCT Number )
|First Posted:
|February 3, 2014 Key Record Dates
|Last Update Posted:
|July 2, 2019
|Last Verified:
|June 2019
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
Breast Cancer
Non Small Cell Lung Cancer
Gastric Cancer
FGFR abnormality
Dose Escalation
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type


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Top Pick
Get the Peach Bowl stream and much more on Hulu Live TV. You can try it free for a week!
Also Good
Save some money and enjoy the Florida vs Michigan game on Sling TV. Free for 7 days!
Also Good
Enjoy a huge channel selection and Peach Bowl streaming on DIRECTV NOW. Free 7 day trial.
The college football season is always punctuated by great bowl games, and the Peach Bowl is perennially one of the can't-miss matchups. This year, the Florida Gators take on the Michigan Wolverines, with the action kicking off at noon ET on Saturday. For fans who have cut the cord and no longer have cable, finding a way to watch the Peach Bowl online without cable is essential. Thankfully, there are more legal streaming options than ever!
You'll have several options on how to watch the Peach Bowl live stream, and we'll detail them all in the guide below. You can watch with a few streaming services that let you stream cable channels live.
Watch Florida vs Michigan Online via Hulu Live TV
Hulu Live TV is a newer streaming service that presents a great option for sports fans. For $40 a month – with no contract – you can sign up and get ESPN, FOX, NBC, TNT, FS1 and much more! You can stream these channels live on all your devices, such as streaming players and smartphones.
Since ESPN is included, Peach Bowl streaming is included! You'll also have access to all the other Bowl games of the season, and TONS more. And for times when there's nothing on, Hulu offers an extensive on-demand library to enjoy. Read our Hulu Live TV review to learn more.
Click here to try a FREE 7-day trial!
Sling TV is Another Great Way to Watch a Peach Bowl Live Stream
Sling TV is another frontrunner for how to watch Peach Bowl online. You can watch the game right from ESPN and the starting price on Sling TV is only $25 per month. This makes it the cheapest of the live streaming services, and another great way to stream the game. Sling TV can also be watched on a variety of devices, including your TV (with a streaming player), your phone, laptops, computers, and more.
You can also watch a Peach Bowl stream free on Sling TV, since there is a 7-day free trial offered by Sling TV.
Check out DIRECTV NOW for the Peach Bowl Live Stream
DIRECTV NOW is one of the most popular ways to get a Peach Bowl live stream. The live streaming service starts at $40 per month and includes a number of great channels to stream directly to your devices (e.g. Apple TV, Roku, Fire TV, iOS devices, Android devices, and more). ESPN is included in the bunch, which will be the channel broadcasting the bowl game. There's no contract, so just pay month to month and cancel any time.
Plus, DIRECTV NOW is a great option to watch a Peach Bowl stream free with the 7-day free trial! For any other questions, check out our DIRECTV NOW review.
Watch the Peach Bowl Without Cable via YouTube TV
YouTube TV is a new service launched by Google that lets you watch live TV without cable. This year it will be a good option for College Bowl streaming. It offers ESPN – home to most of the Bowl games – as well as 50+ other great channels for $50 a month.
For the full channel list check out our YouTube TV review. You can also get started with a free trial.
Watch a Peach Bowl Live Stream on PlayStation Vue
Another solid option to watch a Peach Bowl stream is Sony's streaming service, PlayStation Vue. The price is slightly higher than the other services at $44.99 per month.
PlayStation Vue (review) is available on more than just PS consoles, including on streaming players, smart phones, and tablets. Overall, it's a great way to get a Peach Bowl live stream. There's also a free 5 day trial for new members.
Peach Bowl Schedule & Game Preview
The 2018 Peach Bowl kicks off at 12:00 p.m. ET on Saturday, December 29, 2018. It will air on ESPN.
The Peach Bowl looks like a solid matchup, and it's sure to be a game fans won't want to miss. If you have any questions about how to watch the Peach Bowl online without cable, let us know below.


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The trial of a man accused of kidnapping the mother of his child began in the No. 5 Supreme Court Tuesday.
Fitzgerald Agard, 45, of Pool #2, St John, is charged with assaulting Veronica Arthur on February 2, 2012 and unlawfully removing her from Roberts Road, Haggatt Hall, St Michael without her consent. He has denied both charges.
Madam Justice Jacqueline Cornelius and a nine-member jury – comprised of seven women and two men – are hearing the case which is being prosecuted by Senior Crown Counsel Kyrstal Delaney.
Tuesday morning, the alleged victim took the witness stand. It was disclosed that she and Agard had an agreement that he would collect her and the child from their Burke's Village, St Joseph home and drop them off at work and school.
On the day in question, Arthur told the court Agard arrived at her workplace, the US Embassy, about 5:10 p.m., and was behaving in an aggressive manner.
She said they later went to Digicel in Haggatt Hall to get a problem with her phone rectified, and when she got back to the car, "he was still behaving . . . aggressive".
"I said that I was not getting into the car but he said he was only joking and I got in," Arthur continued.
However, she said, Agard's driving got "reckless" and she asked him to stop the car. He refused and Arthur said she eventually got out of the vehicle while it was still moving.
The woman testified that she held on to a fence and "next thing I know I got an unexpected cuff to the left side of my face from Fitzgerald".
"I let go of the fence . . . he put me into the car and . . . began driving reckless," Arthur continued in response to Delaney's questions.
She said the two subsequently went to Market Hill, St George and she was able to escape about 7:40 p.m.
"I ran across the road . . . . I got a lift," said Arthur, who maintained that her relationship with Agard came to an end in February 2012.
She said she was dropped off at the police station where she reported the matter, but never sought medical attention.
In his cross examination of Agard, the accused, who is representing himself, asked her whether she did not walk past him and go to another car when he came to pick her up from work.
She agreed, saying that she was speaking to the person from whom she had bought the phone, and it was only for a few minutes. However, Agard maintained it was about 25 minutes.
The accused man suggested to Arthur that he walked past her and went to see who was in the car, but she told the court that she could not recall him getting out of the car.
He further suggested that he left Arthur in Haggatt Hall after he saw the same man who was in the car, in the area. However, she denied the charge.
Two police officers, Julian Barker and Fabian Duplesis, also gave evidence in the case.
When it was his turn to testify, Agard gave an unsworn statement from the dock.
"That is my child mother. I lived with her at that time. I took her to work first and then the child to school. I come back for her on the evening," he said about Arthur.
He testified that when he went to collect Agard, she passed him and he called her back and then he went to see the gentleman she was talking with.
"I went back in my car and she came in the car saying she going to Haggatt Hall," Agard continued, adding that he dropped off Arthur at the location, but "the same gentleman was in Haggatt Hall".
"I came back out . . . went to my car. . . . I had keys to her place, took up my things and leave; nothing else," Agard concluded, saying that he was arrested by police a month later.
Moments later, he presented closing arguments to the jury, saying what happened on the day in question was exactly as he had testified.
The case resumes Wednesday at 9:30 a.m., when the judge will sum up the case before sending the jury to deliberate.


text:
In a move which will enable Chinese battery manufacturer CATL to expand its raw material supply, a joint venture for cathode materials is being set up by the company with its subsidiary Brunp Recyc
News in Focus
According to a report by the South China Morning Post, the Chinese government is aiming for an ambitious target of getting 1 million fuel cell vehicles (FCEVs) on the roads by the year 2030.
In a recent statement released shortly ahead of the upcoming IAA event this week, German automaker Volkswagen (VW) has revealed that its limited special edition of the ID.3 is now out of stock.
German automaker Porsche officially unveiled the final production version its first all-electric car -- the 'Taycan' -- on Wednesday, September 4, 2019.
In a recent press release, German automaker BMW has indicated that it will stop producing its i8 plug-in hybrid sports car from April 2020.
Germany-based Fraunhofer Institute for Solar Energy Systems (Fraunhofer ISE) has developed solar roofing for electric vehicles (EVs), in an apparent effort to increase their driving range.
In a recent statement, UK-headquartered capital goods company CNH Industrial has revealed that it is making a $250-million investment in US startup Nikola, which specializes in the production of el
Main Regional Stories
According to Chinese media reports, the country's renowned real estate group Evergrande is cooperating with two German companies to advance its ambitious electric vehicle (EV) plans.
In a recent announcement underscoring an environment-friendly move, the US state of Virginia has said that it is planning the electrification its public school bus fleets.
In a recent announcement, Los Angeles-based charter start-up Quantum Air has revealed that it has signed an agreement with Denver-based Bye Aerospace, for the purchase of 26 small electrically-powered aircraft.
German public transport provider Hamburger Hochbahn is planning to purchase 530 units of electric buses between 2021 and 2025.
Spanish Volkswagen subsidiary Seat has announced that it will soon introduce a plug-in hybrid variant of the Tarraco SUV model.
Chinese battery manufacturer CATL has been officially granted the requisite approval for starting the new construction of its battery cell factory in Erfurt, Germany.
In a recent announcement, the Government of Scotland has revealed the first results of its eBike Grant Fund that enables the purchase of electric bikes across the country.
German automaker Daimler's Smart brand has released the first few images of the revised, 'new-generation' models of its EQ electric car lineup -- the EQ Fortwo, the EQ Fortwo Cabrio, and the EQ For


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<iframe width="560″ height="315″ src="//www.youtube.com/embed/r4LxHDaM-M8″ frameborder="0″ allowfullscreen></iframe> Here is Stage 01, on how to setup your box from start!…. Where to purchase your Own Official North American Order: http://goo.gl/wpwYzv Official World Wide order: Coming SoonRead More »
Official Linux Based XBMC On G-Box Midnight MX2, How-To
Since alot of you guys requested here is a video to make it easier and step by step guide how to load Linux Based XBMC on your G-Box Midnight MX2, Official Matricom Website http://goo.gl/7jgE1C Where to Order your own G-BOX Midnight MX2 Official website to order: http://goo.gl/7jgE1CRead More »
XBMC 13.0 Gotham Alpha 12 on G-Box Midnight MX2 Nightly Built, How-to
Since alot of you guys requested to show you that xbmc 13 works or not working on G-BOX Midnight MX2 here is a video, that yes it works like Charm…Read More »
Super Configure XBMC With New XBMCHUB Wizard
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More Links for TV Desi-Zone XBMC Add-On
Some of you messaged me indicating as soon as you updated you guys lost access to more source links where you would've play your video if one didn't work. We brought this video you guys to show you that option is still there just hidden follow this video for help …Read More »
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AJ add-on Brings a new look for our Indian TV Show lovers, from almost all TV Stations that are from India, this is how you install the New Look Things you need: Install Fusion http servers : http://goo.gl/Y6HltHRead More »
Yatse APP For XBMC On G-BOX Midnight MX2
Since Some poeple don't like the remote and don't want to spend money on another remote here is a video to help you guys control your XBMC easily 1. Download Yatse Free App 2. Give Yatse App Rights to control XBMC under settings 3. Add your IP address and use …Read More »
Measy A2W Miracast Dongle Unboxing & Introduction
Here is yet another awesome little un-expensive device which is created and brought to us via Measy Group Company… Processes alot of different tasks which we have covered on Video talking about it.. Product Knowledge: http://goo.gl/U9EExB Where To Order: (( Coming Soon ))Read More »
Add-On Browser – Free App Store for XBMC
We've been hearing questions like what's a repository, what's an add-on, and all kinds of other terms that are super difficult for the average layman to comprehend. In order to make things easier, we've created a kind of App Store for XBMC (don't worry everything is free) where you can …Read More »
New Add-On Page From XBMCHUB & Revamp Fusion Servers
On this video, we thought its good to bring in a Walk through on how to install One Add-on at the time, plus how to add revamp verison of Fusion Http Servers Things you need: 1. Official Add-on Website Link: http://goo.gl/qnhCLq 2. Visit Xbmchub Website: http://goo.gl/xdFvuj 3. Visit our website …Read More »


text: Triple Kill Release Debut Album 'Age Of Rebellion' 09/10/2018 News 8 This is it! The moment you've all been waiting for! Melbourne's much loved metal warriors Triple Kill unleash their debut album 'Age Of Rebellion' today! After the hype surrounding their two single releases over the last few weeks it's time to wrap your ears around the rest of the album with a total of 9 tracks to indulge in! If you loved The Alchemist and Fear The Old Blood then you are bound to love the rest. Triple Kill's guitarist, Anthony Commane asked the rest of the band how they all felt about the new album, this was their response: "Horny, Thick, Moist"… and "You know that gut feeling when you're on the edge of a diving board, you're nervous and about to throw up, but then you finally jump? It's the feeling once you get out of the pool and realize you wanna go again". Commane added: "Which sums it up very well for all of us. We're in the water now, our first album is pretty much out. We enjoyed the hell out of this experience and we're super happy with ourselves for making the jump. Go listen to what our bathing suit clad temples of flesh have developed. When we're ready to climb out of the pool, we're getting right back on that horny, thick and moist diving board and diving in for round two. We just hope people who have seen us make this jump, get it stuck in their heads and hopefully fall in love with the work that we fell in love with. Doing this makes us happy. Very Happy." To listen to 'Age Of Rebellion' click HERE. 'Age Of Rebellion' Track listing: 1. Event Horizon 2. Age of Rebellion 3. Lords of Cinder 4. Decay 5. Fear the Old Blood 6. Forward Unto Hell 7. Rán 8. The Alchemist 9. Tears of a Burning Messiah [youtube https://www.youtube.com/watch?v=1Fh0ulrzQRs] Melbourne's Heavy Metal stallions, Triple Kill are known for their incredibly witty and humorous film clips and promotional videos. They'll make you laugh one minute then have you in awe of their amazing talent and brilliant music the next. They might have a great sense of humor and love to get their fan's laughing, but they also take their music and the band very seriously. Triple Kill are lifelong best friends with Rodney Goolagong on vocals, Anthony Commane and Daniel Mackie on guitars, Efun White on bass and Connor O'Keane on drums. The band first formed back in 2015 and from the very beginning they have been committed and passionate about the band and their music. After releasing their debut EP 'The First Kill' in July 2017, they are now extremely excited to release their debut album 'Age Of Rebellion'. Triple Kill's album 'Age Of Rebellion' is available to purchase now! Click HERE to order. The album launch gig is Saturday October 13th, click HERE to get your tickets and for more details. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Like this:Like Loading... Leave a Reply Cancel ReplyYour email address will not be published.CommentName* Email* Website This site uses Akismet to reduce spam. Learn how your comment data is processed.