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In this Section
- Office of the Scientific Director
- Office of the Clinical Director
- NIAAA Laboratories
- Laboratory of Behavioral & Genomic Neuroscience
- Laboratory of Cardiovascular Physiology and Tissue Injury
- Laboratory for Integrative Neuroscience
- Laboratory of Liver Diseases
- Laboratory of Metabolic Control
- Laboratory of Molecular Signaling
- Laboratory of Molecular Physiology
- Laboratory of Membrane Biochemistry and Biophysics
- Laboratory on Neurobiology of Compulsive Behaviors
- Laboratory of Neurogenetics
- Laboratory of Physiologic Studies
- Chemical Biology Research Branch (joint lab with NIDA)
- Clinical NeuroImaging Core
- Laboratory of Neuroimaging
- Section on Clinical Genomics and Experimental Therapeutics (CGET)
- Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)
- Section on Human Psychopharmacology (HP)
- Office of Laboratory Animal Science (OLAS)
- Join a Study - Clinical Research
- Section of Comparative Behavioral Genomics
- DICBR Organization Chart
- Technology Transfer
Section on Human Psychopharmacology (HP)
Division of Intramural Clinical and Biological Research
National Institute on Alcohol Abuse and Alcoholism
National Institutes of Health
10 Center Drive, Room 10-CRC/2-2352: MSC 1540
Bethesda, MD 20892-1540
What we do
The Section conducts studies characterizing the pharmacokinetics and CNS pharmacodynamics of alcohol in humans using behavioral, neuroendocrine, electrophysiological and functional imaging measures. These studies, conducted in social and high-risk drinkers, enable the evaluation of genetic and environmental risk factors influencing the acute and adaptive responses to alcohol. The Section is also conducting studies to develop human laboratory paradigms that can be used to screen novel potential treatments for alcoholism in terms of their ability to alter the pharmacological effects of alcohol and/or alcohol self-administration behavior.
Two alcohol administration methods form the foundation of our work: (1) the alcohol clamp, and (2) computer-assisted self-infusion of ethanol (CASE). Both methods employ intravenous (IV) administration of alcohol solutions, which when combined with a physiologically-based pharmacokinetic (PBPK) model for ethanol, results in systemic (and therefore brain) alcohol exposures that are extremely precise and well-controlled. These methods provide a unique platform for studies evaluating the influence of risk factors including sex, age, drinking history and genetic polymorphisms on alcohol responses and alcohol self-administration behavior in human laboratory studies.
08-AA-0178: Computer-Assisted Self-Administration of Ethanol (CASE) in Humans (PI: Vijay A. Ramchandani, PhD)
16-AA-0037: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues in Heavy Drinkers: Role of OPRM1 Gene Variation (PI: Vijay A. Ramchandani, PhD)
17-AA-0171: Nicotinic Receptor Genetic Variation and Alcohol Reward (PI: Vijay A. Ramchandani, PhD)
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Current Staff
Vijay A. Ramchandani, Ph.D.
Tenure-Track Clinical Investigator and Chief
telephone: 301-402-8527
email: email@example.com
Vijay Ramchandani obtained his undergraduate degree in Pharmaceutical Sciences from Bombay University in India in year 1990 and Ph.D. in Pharmaceutical Sciences from Virginia Commonwealth University, Richmond, VA in 1996. From 1996 to 2002, he worked at the Alcohol Research Center at Indiana University School of Medicine, Indianapolis, IN, first as a Research Associate and then as an Assistant Scientist and Part-time Assistant Professor. In 2003, Dr. Ramchandani joined NIAAA as a Staff Scientist in the Laboratory of Clinical and Translational Studies (LCTS), and in 2007, he became Chief of the Unit on Human Physiology and Pharmacokinetics. In March 2010, Dr. Ramchandani was appointed as a Tenure-track Clinical Investigator and Acting Chief of the Section on Human Psychopharmacology.
Bethany Stangl, Ph.D.
Research Scientist
telephone: 301-451-9401
email: firstname.lastname@example.com
Dr. Stangl joined the Section as a postdoctoral fellow in September 2010. She earned her undergraduate degree at Dickinson College and her PhD in cognitive neuroscience at The George Washington University. She became a Research Fellow in the Section in November 2015 and Research Scientist in October 2018. Her research uses the Computer-Assisted Self-Administration of Ethanol (CASE) protocol that uses this IV alcohol method to assess alcohol-seeking and consumption behavior that is driven primarily by the pharmacological effects of alcohol. To better characterize the motivation for alcohol, she extended this model to develop a novel progressive-ratio paradigm. Most recently her interest in the effects of stress and alcohol cues on alcohol-seeking behavior led her to develop a new method combining CASE with acute stress exposure using personalized guided imagery scripts. Other interests include studying the relationship between childhood trauma, early life stress, genetics, and risk for substance use disorders in humans.
Soundarya Soundararajan, MBBS, Ph.D.
Postdoctoral Visiting Fellow
telephone: 301-827-0566
email: firstname.lastname@example.com
Soundarya completed her medical training and earned MBBS degree from Stanley Medical College, Chennai, India and pursued her PhD in Clinical Neurosciences from National Institute of Mental Health and Neurosciences (NIMHANS), India. Soundarya joined the NIAAA as a Postdoctoral Visiting Fellow in September 2018. Soundarya has clinical and research experience in treating Substance Use Disorders with a special interest in Alcohol Use Disorders. During her PhD, she studied epigenetic changes associated with chronic alcohol use among treatment-seeking subjects with alcohol dependence. Her interests and works include genetics and genomics of alcohol sensitivity and alcohol consumption behaviors. In her future, she aims to employ this knowledge to study pharmacogenomics to understand factors affecting treatment response in Alcohol Use Disorders.
Benson Stevens, Ph.D.
Postdoctoral Fellow
telephone: 301-451-6968
email: firstname.lastname@example.com
Benson defended his PhD dissertation in Neuroscience at Georgetown University in 2017, and also completed a 1-year Post Doc at Georgetown in 2018. Benson then joined the NIAAA as a Postdoctoral Fellow in October 2018. During his PhD, he studied the effects of genetic polymorphisms associated with adult alcohol use problems on adolescent cognition utilizing fMRI. During his first Post Doc, he used fMRI to study cross-modal interactions of the somatosensory, auditory and visual sensory systems. His current interests include how genetics influence alcohol sensitivity and alcohol consumption behaviors, and the underlying neural mechanisms involved.
Brenda S Stidham BSN, MSPH, RN
Clinical Research Nurse
telephone: 301-451-6964
email: email@example.com
Brenda S Stidham RN BSN, MSPH joined the section December 03, 2018. Brenda completed her BSN at Eastern Kentucky University, Richmond, Kentucky, Master of Public Health at the University of Kentucky, Lexington, Kentucky and studied at Uniformed Services University in the College of Nursing, Bethesda, Maryland. Brenda has 15 years of clinical research experience as a research nurse coordinator and coinvestigator. Her nursing experience includes work in critical care to include Intensive Care, Coronary Care and the Emergency Room. In these clinical roles she acquired excellent assessment skills and worked with numerous clinicians caring for the critically ill patients to prevent adverse events. Brenda relocated from the Veterans Health Administration Medical Center in in Gainesville, Florida to serve at Walter Reed National Military Medical Center located in Bethesda, Maryland. While there she served ill and injured service members as a polytrauma nurse liaison between the Veterans Health Administration and the Department of Defense. In this role, she facilitated the transfer process of the severely ill and injured service members from Walter Reed Military Medical Center to one of 5 Veterans Health Administration Polytrauma Rehabilitation Centers of Excellence. The position required clinical problem solving, utilization of electronic medical records and prevention of adverse patient outcomes.
Sumedha Chawla, MBBS, MPH
Clinical Research Coordinator
telephone: 301-435-9397
email: email@example.com
Sumedha Chawla joined the Section as a Clinical Research Coordinator in September 2018. She completed her medical training and earned MBBS degree at Era's Lucknow Medical College, India and her Master's in Public Health at The University of Texas Health Science Center, Houston. As a medical research professional, Sumedha has over 5 years of experience managing and coordinating industry sponsored and investigator initiated clinical research trials. As a Clinical Research Coordinator for the Section, Sumedha will collaborate with the section staff to plan, prepare, implement, and monitor clinical research activities, and provide assistance in the writing, preparation, and submission of material to the Institutional Review Board (IRB) and the Food and Drug Administration (FDA).
Julia Swan, B.A.
Post-Baccalaureate IRTA Fellow
telephone: 301-451-0308
email: email@example.com
Julia Swan received her B.A. in Psychology and English from the University of Michigan, Ann Arbor in May 2017 and joined the Section soon after graduation. She is currently assisting with the Resist version of the Computer-Assisted Self-Administration of Ethanol (CASE) protocol and the Nalmefene protocol by recruiting and screening participants, administering psychological evaluations, and running experimental sessions for the study. Julia is interested in understanding the relationship between alcohol use disorders, decision making, and functional neuroimaging, and she plans to pursue a Ph.D. in Clinical Psychology.
Nia Byrd, B.S.
Post-Baccalaureate IRTA Fellow
Undergraduate Scholarship Program Scholar
telephone: 301-827-0905
email: email@example.com
Nia Byrd received her B.S. in Biopsychology Cognition Neuroscience with a minor in AfroAmerican and African Studies from The University of Michigan in April 2017 and joined the NHGRI as an Undergraduate Scholarship Program (UGSP) summer trainee shortly after graduation. Her previous research focused on understanding the role of caregivers for children with severe inherited conditions using their social networks. After working in the Social and Behavioral Science Branch for the summer, she joined this section. Nia currently works on protocols where she is involved with screening participants, administering psychological evaluations, and running experimental sessions. Her research interests focus on addiction, women's health, mental illnesses, and health disparities. In the future, Nia plans to attend medical school for a dual M.D/M.P.H. degree.
Nancy Elizabeth Ortega, B.A.
Undergraduate Scholarship Program Scholar
telephone: 301-451-8923
email: email@example.com
Nancy Elizabeth Ortega received her B.A. in Psychology from the University of San Francisco in May 2017, and joined the NICHD as an Undergraduate Scholarship Program (UGSP) post-baccalaureate trainee shortly after graduation. After spending a year in the Section on Nervous System Development and Plasticity, she joined the Section on Human Psychopharmacology in May 2018. Nancy's previous research experience focused on the effects of corticosterone and anti-cholinesterase agents on oligodendrocyte development in an animal model of Gulf War Illness. She is currently working on the Resist version of the Computer-Assisted Self-Administration of Ethanol (CASE) protocol where her duties include screening participants, running experimental sessions, and administering psychological evaluations. Nancy plans on attending graduate school for a Ph.D. in Clinical Psychology, where she plans on studying mental health disparities through a neuropsychological approach.
Alexandra Cowand, B.A.
Post-Baccalaureate IRTA Fellow
telephone: 301-496-8186
email: email@example.com
Alexandra (Alex) Cowand received her B.A. in Mathematics with a minor in Neuroscience from the University of North Carolina at Chapel Hill in May 2018 and joined the section shortly after graduation. She is currently working on the Nalmefene protocol where her duties include recruiting and screening participants, running experimental sessions, and administering psychological evaluations. Her research interests include the intersection of mathematics with neuroscience and neuroimaging. Alex plans to pursue a Ph.D. in Neuroscience or Quantitative Psychology.
James Keoni Morris, B.S.
Post-Baccalaureate IRTA Fellow
telephone: 301-451-7605
email: email@example.com
James Morris received his B.S. in Criminology and Psychology from Florida State University in May of 2018 and joined the Section that summer. He is involved in screening participants, administering psychological evaluations, and running experimental sessions for various protocols. James's research interests include substance use tendencies of people involved in the criminal justice system and the mechanisms by which the justice system evaluates and treats persons with psychological disorders. After his time at NIH, James plans on attending graduate school for Clinical Psychology.
Collaborators and Special Volunteers
Vatsalya Vatsalya, M.D. Pg.D. M.Sc. M.S.
telephone: 502-852-8928
email: firstname.lastname@example.com
Dr. Vatsalya has been a Special Volunteer since February 2014. He is a research scientist in the Department of Medicine at the University of Louisville School of Medicine, Louisville KY. His interests include novel human paradigm for alcoholism; identifying treatment for alcoholism; pathophysiological and psychobehavioral evaluations; vulnerable and comorbid conditions [age and sex factors, viral infection]; and biomarkers of alcoholism and alcohol-based organ injury.
Jia Yan, Ph.D., M.S., C.G.C.
email: email@example.com
Dr. Yan has been a Special Volunteer since July 2015, after completing a postdoctoral fellowship in the Section. Dr. Yan obtained an M.S. in Genetic Counseling and Ph.D. in Human and Molecular Genetics through a dual degree program at Virginia Commonwealth University. Her training integrated clinical genetic counseling experience with research on alcohol dependence using statistical genetics methods at the Virginia Institute for Psychiatric and Behavioral Genetics. Her previous work investigated the use of genetic information in clinical risk prediction for alcohol dependence. Her postdoctoral work focused on the quantitative analysis of genetic and phenotypic data using genome-wide and systems-based approaches. She currently works at the Johns Hopkins University McKusick-Nathans Institute of Genetic Medicine on the clinical genetics team and is a practicing genetic counselor in the pediatric and adult medical genetics clinic. She is continuing to do research and see patients, with the aim of integrating genetic counseling and research on alcohol use disorders.
Joanna Sells, M.S.
email: email@example.com
Joanna is a Clinical Psychology Ph.D. candidate at Uniformed Services University (USU) in Bethesda, MD. She is completing her dissertation in collaboration with Dr. Andrew Waters and Dr. Vijay Ramchandani. Together, they are examining the association between impaired control over alcohol self-administration in the laboratory and in the field using smart phones. Joanna's clinical training is focused on treating and assessing military and Veteran populations with emphasis on PTSD and substance use disorders. Joanna is also developing her skillset in public policy, completing an internship in the Executive Office of the President, Office of National Drug Control Policy.
Joshua Gowin, Ph.D.
email: email@example.com
Dr. Joshua Gowin has been a Special Volunteer since July 2018, after completing a postdoctoral fellowship in the Section. Dr. Gowin earned his Ph.D. in 2011 in behavioral neuroscience and psychopharmacology from the University of Texas Health Science Center in Houston. Starting in 2012, he did a one year fellowship at the University of California San Diego where he became a scan operator for fMRI studies and learned to analyze imaging data. He is interested in developing neuroimaging as a predictive tool to determine which individuals are likely to develop substance use disorders using machine learning algorithms.
Matthew Sloan, M.D.
email: firstname.lastname@example.com
Dr. Matthew Sloan has been a Special Volunteer since June 2018, after completing a postdoctoral fellowship in the Section. Dr. Sloan completed his medical training and Psychiatry residency at McGill University. He is in the process of completing a Master's Degree in Psychiatry in which his thesis project examines the effects of stressful life events and coping styles on alcohol and drug use in a cohort of young adults. His current work includes the development of a human laboratory model to study impaired control in heavy drinkers, a PET study evaluating the effect of alcohol on the endogenous opioid system in humans, and the investigation of novel pharmacological treatment strategies for alcohol use disorder. His clinical practice in Montreal primarily focuses on treating patients with substance use disorders and a wide range of psychiatric comorbidities.
Courtney Vaughan, B.S., B.A.
email: firstname.lastname@example.com
Courtney is an alumna of the Undergraduate Scholarship Program (UGSP) and the Post-Baccalaureate Intramural Research Training Award (IRTA) Fellowship program. She joined the Section shortly after graduating from Virginia Commonwealth University in 2015 with a B.S. in Psychology and a B.A. in Gender, Sexuality and Women's Studies. In her three years with the Section, Courtney completed the Script, Progressive Ratio, and pilot for the Resist versions of the Computer Assisted Self-Administration of Ethanol (CAIS) protocols. Courtney is currently a graduate student at the Uniformed Services University of the Health Sciences (USUHS) studying Clinical Psychology under advisor Dr. Andrew Waters. She will continue her work on the RCASE protocol through a collaboration between Dr. Ramchandani and Dr. Waters investigating ecological momentary assessment (EMA) data. Courtney's research interests include cognition, impaired control and impulsivity and how these concepts relate to the cycle of addiction.
Section Alumni
Postdoctoral/Visiting Fellows
Vatsalya Vatsalya (2009-2014)
Bethany Stangl (2010-2015)
Jia Yan (2012-2015)
Joshua Gowin (2013-2018)
Matthew Sloan (2015-2018)
Postbaccalaureate/Technical IRTA (Intramural Research Training Award) Fellows
Mike Hoefer (2004-2005)
Nina Saxena (2005-2006)
Shilpa Kumar (2006-2007)
Seth Eappen (2007-2008)
Julnar Issa (2008-2010)
Megan Cooke (2009-2011)
Molly Zametkin (2010-2014)
Marion Coe (2011-2013)
Jonathan Westman (2013-2015)
Kristin Corey (2014-2015)
Lauren Blau (2014-2016)
Anuj Shah (2015-2016)
Courtney Vaughan (2015-2018)
Corbin Ester (2016-2017)
Honoreé Brewton (2016-2017)
Alyssa (Allie) Schneider (2016-2018)
James Hollingsworth (2017-2018)
Summer Students/Trainees
Elizabeth Edenberg (Summer 2003)
Molly Carroll (Summer 2004)
Satjit Brar (Summer 2007)
Aishini Thiyagarajan (Summer 2008, 2009, 2010)
EB Grasser (Summer 2009)
Elgin Yalin (Summer 2016)
Khem Plata (Summer 2017)
Shaliciana Burrell (Summer 2018)
Special Volunteers/Coordinators
Veronica Schmidt (2010-2014)
Adnan Durrani (2014-2015)
Tasha Cornish (2016-2017)
Donovan Stock (2017-2018)
Nurse Trainees from Kurihama Medical and Addiction Center, Japan
Kaori Abe (Fall 2011)
Tomoko Nakao (Spring 2012)
Tohru Numano (Fall 2012)
Ryo Chinen (Fall 2013)
Haruna Kawamata (Summer/Fall 2014)
Tomoyasu Matsui (Spring/Summer 2016)
Selected Publications
Original Papers:
- Li T-K, Beard JD, Orr WE, Kwo PY, Ramchandani VA. Gender and ethnic differences in alcohol metabolism. Alcohol Clin Exp Res 22:771-772 (1998).
- Kwo PY, Ramchandani VA, O'Connor S, Amann D, Carr LG, Sandrasegaran K, Kopecky K, Li T-K. Gender differences in alcohol metabolism: Relationship to liver volume and effect of adjusting for lean body mass. Gastroenterology 115:1552-1557 (1998).
- Ramchandani VA, Bolane J, Li T-K, O'Connor S. A physiologically-based pharmacokinetic (PBPK) model for alcohol facilitates rapid BrAC clamping. Alcohol Clin Exp Res 23:617-623 (1999).
- Ramchandani VA, O'Connor S, Blekher T, Kareken D, Morzorati S, Nurnberger Jr. J, Li T-K. A preliminary study of acute responses to clamped alcohol concentration and family history of alcoholism. Alcohol Clin Exp Res 23:1320-1330 (1999).
- Li T-K, Beard JD, Orr WE, Kwo PY, Ramchandani VA, Thomasson HR. Variation in ethanol pharmacokinetics and perceived gender and ethnic differences in alcohol elimination. Alcohol Clin Exp Res 24:415-416 (2000).
- O'Connor S, Ramchandani VA Li T-K. PBPK modeling as a basis for achieving a steady BrAC of 60±5 mg% within ten minutes. Alcohol Clin Exp Res 24:426-427 (2000).
- Ramchandani VA, Kwo PY, Li T-K. Influence of food and food composition on alcohol elimination rates in healthy men and women. J Clin Pharmacol 41:1345-1350 (2001).
- Li T-K, Yin S-J, Crabb DW, O'Connor S, Ramchandani VA. Genetic and environmental influences on alcohol metabolism in humans. Alcohol Clin Exp Res 25:136-144 (2001).
- Sato N, Lindros KO, Baraona E, Ikejima K, Mezey E, Jarvelainen H, Ramchandani VA. Gender differences in alcohol-related organ injury. Alcohol Clin Exp Res 25:49S-53S (2001).
- Blekher T, Beard JD, O'Connor S, Orr WE, Ramchandani VA, Miller K, Yee RD, Li T-K. Response of saccadic eye movements to alcohol in African American and non-Hispanic White college students. Alcohol Clin Exp Res 26:232-238 (2002).
- Morzorati SL, Ramchandani VA, Flury L, Li T-K, O'Connor S. Self-reported subjective perception of intoxication reflects family history for alcoholism when breath alcohol levels are constant. Alcohol Clin Exp Res 26:1299-1306 (2002).
- Blekher T, Ramchandani VA, Flury L, Foroud T, Kareken D, Yee R, Li T-K, O'Connor S. Saccadic eye movements are associated with a family history of alcoholism at baseline and after exposure to alcohol. Alcohol Clin Exp Res 26:1568-1573 (2002).
- Ramchandani VA, Flury L, Morzorati S, Kareken D, Blekher T, Foroud T, Li T-K, O'Connor S. Recent Drinking History: Association with family history of alcoholism and the acute response to alcohol during a 60 mg% clamp. J Stud Alcohol 63:734-744 (2002).
- Morzorati SL, Ramchandani VA, Li T-K, O'Connor S. A method to achieve and maintain steady tate blood alcohol levels in rats using a physiologically-based pharmacokinetic model. Alcohol 28:189-195 (2002).
- Neumark YD, Friedlander Y, Durst R, Leitersdorf E, Jaffe D, Ramchandani VA, O'Connor S, Carr LG, Li T-K . Alcohol dehydrogenase (ADH2) polymorphisms influence alcohol elimination rates in a male Jewish population. Alcohol Clin Exp Res 28:10-14 (2004).
- Kareken DA, Claus ED, Sabri M, Dzemidzic M, Kosobud AEK, Radnovich AJ, Hector D, Ramchandani VA, O'Connor SJ, Lowe M, Li T-K. Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: Preliminary findings. Alcohol Clin Exp Res 28:550-557 (2004).
- Khaole NCO, Ramchandani VA, Viljoen DL, Li T-K. Systemic alcohol exposure during free-choice drinking in women with or without a child with fetal alcohol syndrome. Alcohol Alcohol 39:503-508 (2004).
- Plawecki MH, DeCarlo RA, Ramchandani VA, O'Connor S. Estimation of ethanol infusion profile to produce a specified BrAC time course using physiologically-based pharmacokinetic (PBPK) models. IEEE Engineering in Medicine and Biology Society International Conference Proceedings. 1:778-781 (2004).
- Ramchandani VA, O'Connor S, Neumark YD, Zimmermann US, Morzorati SL, de Wit H. The alcohol clamp: Applications, challenges and new Directions – An RSA 2004 symposium summary. Alcohol Clin Exp Res 30:155-164 (2006).
- Han J-J, Plawecki MH, Doerschuk PC, Ramchandani VA, O'Connor S. Ordinary differential equation models for ethanol pharmacokinetics based on anatomy and physiology. IEEE Engineering in Medicine and Biology Society International Conference Proceedings. (article 4029183) 1:5033-5036 (2006).
- Plawecki MH, DeCarlo R, Ramchandani VA, O'Connor S. Improved transformation of morphometric measurements for a priori parameter estimation in a physiologically-based pharmacokinetic model of ethanol. Biomedical Signal Processing and Control 2:97-110 (2007).
- Salloum JB, Ramchandani VA, Bodurka J, Rawlings R, Momenan R, George D, Hommer DW. Blunted rostral anterior cingulate response during a simplified decoding task of negative emotional facial expressions in alcoholic patients. Alcohol Clin Exp Res 31:1490-1504 (2007).
- Gilman J, Ramchandani VA, Davis M, Bjork JM, Hommer DW. Why we like to drink: An fMRI study of the rewarding and anxiolytic effects of alcohol. J Neurosci. 28:4583-4591 (2008).
- Taylor RE, Raysor BR, Kwagyan J, Ramchandani VA, Kalu N, Powell-Davis M, Ferguson CL, Carr LG, Scott DM. Alterations in ethyl alcohol pharmacokinetics during oral consumption of commercial malt liquor beverages. Alcohol Clin Exp Res 32:2074-2080 (2008).
- Plawecki MH, Han JJ, Doerschuk PC, Ramchandani VA, O'Connor SJ. Physiologically based pharmacokinetic (PBPK) models for ethanol. IEEE Trans Biomed Eng 55:2691-2700 (2008).
- Ramchandani VA, Plawecki M, Li T-K, O'Connor S. Intravenous ethanol infusions can mimic the time course of breath alcohol concentrations following oral alcohol administration in healthy volunteers. Alcohol Clin Exp Res 33:938-944 (2009).
- George DT, Herion D, Jones CL, Phillips MJ, Hersh J, Hill D, Heilig M, Ramchandani VA, Geyer C, Spero DE, Singley ED, O'Malley SS, Bishai R, Rawlings RR, Kunos G. Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers. Psychopharmacology 208:37-44 (2010).
- Lee J, Ramchandani VA, Hamazaki K, Engleman EA, McBride WJ, Kim H-Y. A critical evaluation of influence of ethanol and diet on salsolinol enantiomers in humans and rats. Alcohol Clin Exp Res 34:242-250 (2010).
- Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt ML, Sommer WH, George DT, Parsons LH, Herscovitch P, Hommer D, Heilig M. A genetic determinant of the striatal dopamine response to alcohol. Mol Psychiatry 16:809-817 (2011).
- Roh S, Matsushita S, Hara S, Maesato H, Matsui T, Suzuki G, Miyakawa T, Ramchandani VA, Li T-K, Higuchi S. Role of GABRA2 in moderating subjective responses to alcohol. Alcohol Clin Exp Res 35:400-407 (2011).
- Vatsalya V, Issa JE, Hommer DW, Ramchandani VA. Pharmacodynamic effects of intravenous alcohol on hepatic and gonadal hormones: Influence of age and sex. Alcohol Clin Exp Res 36:207-213 (2012).
- Snell L, Ramchandani VA, Saba, L, Herion D, Heilig M, George D, Pridzun L, Helander A, Schwandt M, Phillips M, Hoffman P, Tabakoff B. The Biometric Measurement of Alcohol Consumption. Alcohol Clin Exp Res 36:332-341 (2012).
- Gilman JM, Smith AR, Ramchandani VA, Momenan R, Hommer DW. The effect of intravenous alcohol on the neural correlates of risky decision-making. Addiction Biology 17:465-478 (2012).
- Gilman JM, Ramchandani VA, Crouss T, Hommer DW. Subjective and neural responses to intravenous alcohol in young adults with light and heavy drinking patterns. Neuropsychopharmacology 37:467-477 (2012).
- Kalu N, Ramchandani VA, Marshall V, Scott D, Ferguson C, Cain G, Taylor R. Heritability of level of response and association with recent drinking history in non-alcohol dependent drinkers. Alcohol Clin Exp Res 36:1034-1041 (2012).
- Huang M-C, Schwandt ML, Ramchandani VA, George DT, Heilig M. Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients. Alcohol Clin Exp Res 36:1099-1107 (2012).
- Schwandt ML, Heilig MA, Hommer DW, George DT, Ramchandani VA. Childhood trauma exposure and alcohol dependence severity in adulthood: mediation by emotional abuse severity and neuroticism. Alcohol Clin Exp Res 37:984-992 (2013).
- Leggio L, Schwandt ML, Oot EN, Dias AA, Ramchandani VA. Fasting-induced increase in plasma ghrelin is blunted by intravenous alcohol administration: A within-subject placebo-controlled study. Psychoneuroendocrinology 38:3085-3091 (2013).
- Marshall VJ, Ramchandani VA, Kalu N, Kwaygan J, Scott DM, Ferguson CL, Taylor RE. Evaluation of the influence of ADH polymorphisms on alcohol elimination rates measured using the alcohol clamp. Alcohol Clin Exp Res 38:51-59 (2014).
- Huang M-C, Schwandt ML, Chester J, Kirchhoff A, Kao C-F, Liang T, Tapocik J, Ramchandani VA, George DT, Hodgkinson C, Goldman D, Heilig M. FKBP5 Moderates Alcohol Withdrawal Severity: Human Genetic Association and Functional Validation in Knockout Mice. Neuropsychopharmacology 39:2029-2038 (2014).
- Mitchell MC, Teigen EL, Ramchandani VA. Absorption and peak blood alcohol concentration after drinking beer, wine or spirits. Alcohol Clin Exp Res 38:1200-1204 (2014).
- Vatsalya V, Momenan R, Hommer DW, Ramchandani VA. Cardiac Reactivity during the ascending phase of Acute Intravenous Alcohol Exposure and Association with Subjective Perceptions of Intoxication in Social Drinkers. Alcohol Clin Exp Res 38:1247-1254 (2014).
- Kwako LE, Schwandt ML, Sells JR, Ramchandani VA, Hommer DW, George DT, Sinha R, Heilig M. Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes. Addict Biol, 20:733-746 (2014). Epub: doi: 10.1111/adb.12150.
- Strang NM, Claus ED, Ramchandani VA, Graff-Guerrero A, Boileau I, Hendershot CS. Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults. Psychopharmacology 232:733-744 (2014).
- Wallen GR, Brooks AT, Whiting B, Clark R, Krumlauf MC, Yang L, Schwandt ML, George DT, Ramchandani VA. The prevalence of sleep disturbance in alcoholics admitted for treatment: A target for chronic disease management. Fam Community Health 37:288-297 (2014).
- Spagnolo P, Ramchandani VA, Schwandt ML, Zhang L, Blaine S, Usala J, Diamond C, Phillips M, Momenan R, George DT, Heilig M,. Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol dependent patients. Alcohol Clin Exp Res 38:3024-3032 (2014).
- Gilman JM, Smith AR, Bjork JM, Ramchandani VA, Momenan R, Hommer DW. Cumulative gains enhance striatal response to reward opportunities in alcohol-dependent patients. Addict Biol 20:580-593 (2015). Epub: doi: 10.1111/adb.12147.
- Hendershot CS, Wardell JD, Strang NM, Markovich MS, Claus ED, Ramchandani VA. Application of an alcohol clamp paradigm to examine inhibitory control, subjective responses, and acute tolerance in late adolescence. Exp Clin Psychopharmacol 23:147-158 (2015).
- Suchankova P, Yan J, Schwandt ML, Stangl BL, Caparelli EC, Momenan R, Jerlhag E, Engel JA, Hodgkinson CA, Egli M, Lopez MF, Becker HC, Goldman D, Heilig M, Ramchandani VA, Leggio L. The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence. Transl Psychiatry 16;5:e583. doi: 10.1038/tp.2015.68 (2015).
- Vatsalya V, Gowin JL, Schwandt ML, Momenan R, Coe MA, Cooke ME, Hommer DW, Bartlett S, Heilig M, Ramchandani VA. Effects of Varenicline on Neural Correlates of Alcohol Salience in Heavy Drinkers. Int J Neuropsychopharmacol (2015). Epub: doi: 10.1093/ijnp/pyv068.
- Wardell JD, Ramchandani VA, Hendershot CS. A multilevel structural equation model of within- and between-person associations among subjective responses to alcohol, craving, and laboratory alcohol self-administration. J Abnorm Psychol 124: 1050-1063 (2015). Epub: doi: 10.1037/abn0000121.
- Hendershot CS, Claus ED, Ramchandani VA. Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults. Addict Biol 21:125-135 (2016). Epub: doi: 10.1111/adb.12165.
- Gowin JL, Vatsalya V, Westman JG, Schwandt ML, Bartlett S, Heilig M, Momenan R, Ramchandani VA. The effect of varenicline on the neural processing of fearful faces and the subjective effects of alcohol in heavy drinkers. Alcohol Clin Exp Res, 40: 979-987 (2016). Epub: doi: 10.1111/acer.13046.
- Hendershot CS, Wardell JD, McPhee MD, Ramchandani VA. A prospective study of genetic factors, alcohol response phenotypes, and heavy drinking in late adolescence. Addict Biol, (2016) Epub: doi: 10.1111/adb.12397.
- Sells JR, Waters AJ, Schwandt ML, Kwako LE, Heilig M, George DT, Ramchandani VA. Characterization of comorbid PTSD in treatment-seeking alcohol dependent inpatients: Severity and personality trait differences. Drug Alcohol Depend, 163: 242-246 (2016). Epub: doi: 10.1016/j.drugalcdep.2016.03.016.
- Vatsalya V, Pandey A, Schwandt ML, Cave MC, Barve SS, Ramchandani VA, McClain CJ. Safety assessment of liver injury with quetiapine fumarate XR management in very heavy drinking alcohol-dependent patients. Clin Drug Investig, 2016. Epub: 10.1007/s40261-016-0439-2.
- Vatsalya V, Barve SS, McClain CJ, Ramchandani VA. Elevated linoleic acid (a pro-inflammatory PUFA) and liver injury in a treatment naïve HIV-HCV co-infected alcohol dependent patient. J Biosci Med, 4: 23-27 (2016). Epub: doi: 10.4236/jbm.2016.47003.
- Wardell JD, Ramchandani VA, Hendershot CS. Drinking motives predict subjective effects of alcohol and alcohol wanting and liking during laboratory alcohol mediation: A mediated pathway analysis. Alcohol Clin Exp Res, 40: 2190-2198 (2016). Epub: doi: 10.1111/acer.13174.
- Brooks AT, Krumlauf M, Fryer CS, Beck KH, Yang L, Ramchandani VA, Wallen GR. Critical transitions: A mixed methods examination of sleep from inpatient alcohol rehabilitation treatment to the community. PLOS One, 2016. Epub: doi: 10.1371/journal.pone.0161725.
- Stangl BL, Vatsalya V, Zametkin MR, Cooke ME, Plawecki MH, O'Connor S, Ramchandani VA. Exposure-response relationships during free-access intravenous alcohol self-administration in nondependent drinkers: Influence of alcohol expectancies and impulsivity. Int J Neuropsychopharmacol, 2016. Epub: doi: 10.1093/ijnp/pyw090.
- Spagnolo PA, Ramchandani VA, Schwandt ML, Kwako LE, George DT, Hillard CJ, Heilig M. FAAH gene variation moderates stress response and symptom severity in patients with post-traumatic stress disorder and comorbid alcohol dependence. Alcohol Clin Exp Res, 40: 2426-2434 (2016). Epub: doi: 10.1111/acer.13210.
- Vatsalya V, Song M, Schwandt ML, Cave MC, Barve SS, George DT, Ramchandani VA, McClain CJ. Effects of sex, drinking history and omega-3 and omega-6 fatty acids dysregulation on the onset of liver injury in very heavy drinking alcohol dependent patients. Alcohol Clin Exp Res, 40: 2085-2093 (2016). Epub: doi: 10.1111/acer.13197.
- Vatsalya V, Stangl BL, Schmidt VY, Ramchandani VA. Characterization of hangover following intravenous alcohol exposure in social drinkers: methodological and clinical implications. Addict Biol, 2016. Epub: doi: 10.1111/adb.12469.
- Sloan ME, Gowin JL, Yan J, Schwandt ML, Spagnolo PA, Sun H, Hodgkinson CA, Goldman D, Ramchandani VA. Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant. Addict Biol, 2017. Epub: doi: 10.1111/adb.12491.
- Suchankova P, Yan J, Schwadt ML, Stangl BL, Jerlhag E, Engle JA, Hodgkinson CA, Ramchandani VA, Leggio L. The Leu72MET Polymorphism of the Prepro-ghrelin Gene is Associated with Alcohol Consumption and Subjective Responses to Alcohol: Preliminary Findings. Alcohol Alcohol. (2017) Jul 1; 52(4): 425-430. doi: 10.1093/alcalc/agx021
- Sloan ME, Gowin JL, Ramchandani VA, Hurd YL, Le Foll B. The endocannabinoid system as a target for addiction treatment: Trials and tribulations. Neuropharmacology. (2017). Sep 15; 124: 73-83. doi: 10.1016/j.neuropharm.2017.05.031.
- Gowin JL, Sloan ME, Stangl BL, Vatsalya V, Ramchandani VA. Vulnerability for Alcohol Use Disorder and Rate of Alcohol Consumption. Am J Psychiatry. (2017). Aug 4. doi: 10.1176/appi.ajp.2017.16101180.
- Farokhnia M, Grodin EN, Lee MR, Oot EN, Blackburn AN, Stangl BL, Schwandt ML, Farinelli LA, Momenan R, Ramchandani VA, Leggio L. Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals. Mol Psychiatry. 2017 Nov 14. doi: 10.1038/mp.2017.226.
- Gowin JL, Sloan ME, Ramchandani VA, Paulus MP, Lane SD. Differences in decision-making as a function of drug of choice. Pharmacol Biochem Behav. 2018 Jan; 164:118-124. doi: 10.1016/j.pbb.2017.09.007.
- Shah AJ, Singh V, Patil SP, Gadkari MR, Ramchandani V, Doshi KJ. Factors Affecting Compliance to Antihypertensive Treatment among Adults in a Tertiary Care Hospital in Mumbai. Indian J Community Med. 2018 Jan-Mar;43(1):53-55. doi: 10.4103/ijcm.IJCM_40_17.
- Vatsalya V, Stangl BL, Schmidt VY, Ramchandani VA. Characterization of hangover following intravenous alcohol exposure in social drinkers: methodological and clinical implications. Addict Biol. 2018 Jan;23(1):493-502. doi: 10.1111/adb.12469.
- Sloan ME, Gowin JL, Yan J, Schwandt ML, Spagnolo PA, Sun H, Hodgkinson CA, Goldman D, Ramchandani VA. Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant. Addict Biol. 2018 Jan;23(1):474-484. doi: 10.1111/adb.12491.
- Brooks AT, Krumlauf M, Beck KH, Fryer CS, Yang L, Ramchandani VA, Wallen GR. A Mixed Methods Examination of Sleep Throughout the Alcohol Recovery Process Grounded in the Social Cognitive Theory: The Role of Self-Efficacy and Craving. Health Educ Behav. 2018 Mar 1. doi: 10.1177/1090198118757820.
- Bujarski S, Jentsch JD, Roche DJO, Ramchandani VA, Miotto K, Ray LA. Differences in the subjective and motivational properties of alcohol across alcohol use severity: application of a novel translational human laboratory paradigm. Neuropsychopharmacology. 2018 May 8. doi: 10.1038/s41386-018-0086-9.
- Sloan ME, Klepp TD, Gowin JL, Swan JE, Sun H, Stangl BL, Ramchandani VA. The OPRM1 A118G polymorphism: converging evidence against associations with alcohol sensitivity and consumption. Neuropsychopharmacology. 2018 Jun;43(7):1530-1538. doi: 10.1038/s41386-017-0002-8.
Reviews and Book Chapters:
- Ramchandani VA, Bosron WF, Li T-K. Research advances in ethanol metabolism. Pathologie Biologie 49:676-682 (2001).
- Ramchandani VA. Genetic aspects of alcohol metabolism. In Alcohol in disease: Nutrient interactions and dietary intake (Watson RR and Preedy VR, ed). Boca Raton, CRC Press: 187-199 (2004).
- Ramchandani VA, O'Connor S. Studying alcohol elimination using the alcohol clamp method. Alcohol Research and Health 29:286-290 (2006).
- Heilig M, Thorsell A, Sommer WH, Hansson AC, Ramchandani VA, George DT, Hommer D, Barr CS. Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues. Neurosci Biobehav Rev 35:334-344 (2010).
- Hendler RA, Ramchandani VA, Gilman J, Hommer DW. Stimulant and sedative effects of alcohol. Curr Top Behav Neurosci 13:489-509 (2013).
- Zimmermann US, O'Connor S, Ramchandani VA. Modeling alcohol self-administration in the human laboratory. Curr Top Behav Neurosci 13:315-353 (2013).
- Ramchandani VA. Genetic aspects of alcohol metabolism. In Alcohol, Nutrition and Health Consequences (Watson RR, Preedy VR, Zibadi S, ed). New York, Humana Press:15-25 (2013).
- Ramchandani VA, Slattum PW, Patkar AA, Wu L-T, Lee JC, Mohanty M, Coe M, Li T-K. Psychopharmacology and the consequences of alcohol and drug interactions. In: Substance Use and Older People (Crome I, Wu L-T, Rao T, Crome P, ed). United Kingdom, Wiley Blackwell:149-170 (2015).
NIH Research and Training Opportunities


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New Amerykah Part Two: Return of the Ankh album by Erykah Badu.
New Amerykah Part Two: Return of the Ankh album by Erykah BaduPublished March 30, 2010 Music Picks Leave a Comment
New Release Music TuesdayPublished January 19, 2010 New Release Tuesday Leave a Comment
Tags: Charlotte Gainsbourg, cold war kids, Matador Records, Merge Records, Missy Elliott, Music reviews, Music videos, New Release Music Tuesday, Pixies, RJD2, Spoon, the editors, Transference, Wire
The new year is starting to get revved up and is showing some promising new bands and music! This week has proven to be full of goodies with new music from Cold War Kids, The Editors, RJD2, Charlotte Gainsbourg, Missy Elliott and today's new music pick Spoon! I had the opportunity to work on this album (Transference) and really enjoyed it.
Spoon was formed in late 1993 in Austin, Texas and is composed of Britt Daniel (vocals, guitar); Jim Eno (drums); Rob Pope (bass) and Eric Harvey (keyboard, guitar, percussion, backing vocals).
Spoons first recorded album debut came about in 1994 with the release of The Nefarious EP in May 1994. In 1995 the band signed with the well established indie label Matador Records and released their first LP Telephono in 1996. Their first album was met with mixed reviews and were often compared to the Pixies and Wire. Regardless of their comparisons the album showed forward signs of mixing post-funk with a fusion of pop.
They later went on to try their hand at one of the major lables Elektra releasing A Series of Sneaks. The album did not sell as expected and just four months into their new contract they were dropped and later picked up by Merge Records their current label. Much of their commercial success is attributed to Merge's special attention and development of the band. They went on and released five studio albums with Merge and have appeared on The Late Show With David Letterman, Late Night with Conan O'Brien, The Late Late Show With Craig Ferguson, and Last Call with Carson Daly, as well as the PBS show Austin City Limits. They have also appeared as musical guests on the popular weekly improv Saturday Night Live.
Fast forward to January 19th, 2010 with the start of a new decade and a new album Transference.
As in their last album "Ga Ga Ga Ga Ga" we saw the group experiment with hooks and mini horn sections, Transference also broadens the groups experimentation with more textures and moods. Transference begins with "Before Destruction", a reflective slow-burner that's more of a subdued prelude than a flashy entrance. The album's single "Written in Reverse" offers a soulful rock sound, with vocals, guitars and keys barely out of alignment.
"Is Love Forever?", a lively cut that bumps right into "The Mystery Zone", a superior late-night delight that hits the same sweet spot as older gems like "Don't You Evah" and "I Turn My Camera On". As soon a that track ends suddenly, it's like walking right into a wall before "Who Makes Your Money" has you wobbling along with Daniel in a concussed haze. The album tones down and moves along. All in all the album is best described as a big pile-up of unconventional creative decisions, which seems to work for me.
My Top two picks:
Written In Reverse:
Got Nuffin:
Stay tuned for next weeks pick! Enjoy the music!
New Release Music TuesdayPublished January 5, 2010 New Release Tuesday Leave a Comment
Tags: Heads Will Roll, It's Blitz, Music Review, Music videos, NME, Yeah Yeah Yeah's
Happy New Year to all my music enthusiast! The start of the new year shows some promising upcoming new albums, but unfortunately there is no new music this week as the notable new releases starts next week. This week I am revisiting a band that I didn't get the chance to write about in my New Release Music Tuesday column last year. Enjoy this weeks revisited pick from 2009.
The Yeah Yeah Yeahs are an indie rock band that formed in New York City in 2000 and is comprised of vocalist and pianist Karen O, guitarist and keyboardist Nick Zinner and drummer Brian Chase. The band stays true to their NYC grind by naming their band after modern New York City vernacular.
Karen O and Brian Chase both attended Oberlin College in Ohio in the late '90s, and met as students there. Karen then moved to NYC to attend NYU and while in New York met Zinner in a local bar, where they formed an instant bond. The two later formed an acoustic duo called "Unitard", but then decided to go electric after being inspired by Ohio's avant-punk scene. Chase joined the line-up after the drummer they initially recruited bowed out. In late 2001, the Yeah Yeah Yeahs released their self-titled debut EP, which they recorded with Boss Hog's Jerry Teel on their own Shifty label. They also appeared at the highly rated South by Southwest festival in Houston, TX early that year.
Since its inception the band has recorded three studio albums; the first, Fever to Tell, was released in 2003. The second, Show Your Bones, was released in 2006 and was named the second best album of the year by NME. Their latest studio album, It's Blitz!, was released on March 31, 2009.
The album as a whole is impressive. The single Zero transports the audience into a stimulating sea of electrical flare and is perhaps one of the band's finest musical points in their career. Heads Will Roll keeps the uptempo going with its dance feel and lyrics like "Off with your head, dance til your dead". With lyrics like that you definitely won't stand in a club with a drink trying to look cute. Skeletons is filled with monster distant drums and digital tears trickling all over it along with vocals which find Karen at her most astounding.
All in all the album is a solid more polished YYY's sound that is more listener friendly than previous albums, and I can definitely see it reaching a broader audience.
My top two picks are:
Heads Will Roll:
Bonus Pick:
Alright folks. I hope you enjoyed my revisited album pick of 2009! It's a great album filled with a wide range of emotions! Stay tuned for next weeks pick!
Happy New Year!
New Music TuesdayPublished December 22, 2009 New Release Tuesday Leave a Comment
For the first time in 15 years Cleveland's most well known rap group is back and fresh with the release of their new album Uni5: The World's Enemy.
Bone Thugs N Harmony was formed in the early 1990s, and originally consisted of four members: Krayzie Bone, Layzie Bone, Bizzy Bone and Wish Bone. They recorded their first album, Faces Of Death in 1993. After the addition of Flesh-n-Bone the group headed to Los Angeles in search of famous producer and N.W.A. member Eazy-E.
In hopes of securing a record deal, the group was given an audition over the phone receiving an unfulfilled promise from Eazy-E to call them back. Discovering that Eazy-E was performing back in their hometown of Cleveland, the group took a charter bus back to their home turf to open Eazy-E's show and they were then signed to Ruthless Records on the spot.
Known mostly for their fast and smooth flow, rather than lyricism, Bone's style and technique can be described as harmonious, rapid-fire and hawkish. Their style could be best described as a web of high speed, melodic pace or slow, rhythmical pace. They also tend to ride the beat that they're rapping over.
Bone Thugs have released hip hop notable albums Creepin on ah Come Up, E 1999 Eternal and The Art of War with successful hit such as "Thuggish Ruggish Bone", "1st of Da Month", "Crossroads" and "Foe the Love of Money" to name a few.
Uni-5: The World's Enemy is their latest release and offers the same fast, ride the beat flow as previous albums. Their first single "See Me Shine" has a soulful R&B hook mixed in with a smooth flow riding over the beat. The song features Lyfe Jennings singing the hook "They don't wanna, they don't wanna see me shine". This song is definitely for all the haters out there. The Game Ain't Ready demonstrates the evolution of BTNH, combining the group's trademark, machine-gun flow with an updated beat that lets you know they've spent some time not just reminiscing about the past, but on where they want their music to go in the future.
In the end – the album is good and longtime BTNH fans will not be disappointed. Also, the possibility of the group gaining a whole new generation of fans is not out of the question as they have evolved to offer a more modern sound.
My top pick is: See Me Shine:
Hope everyone enjoys the reunion of one hip hops notable rap acts! Good to see them back with fresh new material! Hope everyone enjoys the holidays and we'll see you in the New Year!
Make sure to check out other notable releases this week by
Mary J. Blige – Stronger With Each Tear
Twilight Saga: New Moon Soundtrack – Definitely has some good new artists and songs
New Release Music TuesdayPublished December 15, 2009 New Release Tuesday Leave a Comment
Tags: Alicia Keys, Animal Collective, Fall Be Kind, Grateful Dead, Music Review, Music videos, New Music, New Release Music Tuesday, Robin Thicke, Shiny Toy Guns
We're back! A week has gone by and I am excited to bring yet another great band to you!
Animal Collective came to fruition by childhood friendships formed in Baltimore, Maryland and is composed of Avey Tare (David Portner), Panda Bear (Noah Lennox), Deakin, or Deacon as spelled on Strawberry Jam (Josh Dibb), and Geologist (Brian Weitz). The band members met in school and started recording together at a young age. Lennox and Dibb went off to college in the Boston area while Portner and Weitz attended NYU in NYC. In the summer of 1999 they would all meet back up again in Maryland to record material for the first release in 2000, Spirit They're Gone, Spirit They've Vanished. After the release, Lennox and Dibb moved from Boston to NYC to record and the music became much more collaborative in nature.
Since their first release they have gone on to release 8 studio albums. My introduction to the group didn't come until the release of their 7th studio album Strawberry Jam (2007) and later Merriweather Post Pavillion (2009). Both albums were wonderfully arranged and offered a warm atmospheric feel to them.
In and effort to hold fans over until their next full album release they have decided to drop the EP Fall Be Kind. The EP picks up right where they left off with intense pop chore, numerous harmonies and melodies with trance-like elements that are as hypnotic as they are eccentric. The band seems to keep it's unorthodox, enchantedly complex and unique sound while offering more friendly and simple vocals and general musicianship.
Although it is only an EP, the bands best moment could be on their strangely titled track "What Would I Want? Sky." They have managed to take a brilliant Grateful Dead sample and evolve it into a song that probably has the most eclectic hooks and overall song.
If you like music and it's various eclectic forms then you will truly like this EP!
My top two picks on the EP are:
On the Highway
I Think I Can
Thanks for stopping by this week. Enjoy the new tunes and make sure to check out other notable releases.
Alicia Keys – The Element of Freedom
Robin Thicke – Sex Therapy
Shiny Toy Guns – Girls Le Disko
New Release Music TuesdayPublished December 8, 2009 New Release Tuesday , Uncategorized Leave a Comment
Tags: Billboard, Chris Bown, music, Music videos, New Music, New Release Tuesday, Rihanna
Just two weeks after Rihanna's anticipated and successful release of Rated R comes the release of former hubby Chris Brown's Graffitti.
Christopher Brown was (born May 5, 1989) in the small town of Tappahannock, Virginia to Joyce Hawkins, a former day care center director, and Clinton Brown, a corrections officer at a local prison. He is the youngest child of the couple and one has older sister. Although no-one in his family was related to music it was always around in Brown's life. He used to listen to soul albums that his parents had owned and eventually Brown began to show interest in the hip-hop scene. He went through some personal problems at the time of his engaged interest in music, by the physical abuse his mother endured at the hand of her boyfriend (we wondered where he got it from).
In 2005 his mother saw the vocal talent Chris had and began to shop him around to music labels where he had the chance to audition for then senior A&R executive Tina Davis (Island Def Jam). Tina was impressed and eventually he was signed and officially made his recording debut in late 2005 with the self-titled album Chris Brown at the age of 16.
His debut album featured the hit single "Run It!", which topped the Billboard Hot 100, making Brown the first male artist since Montell Jordan in 1995 to have his debut single top the charts. The album has sold over two million copies in the United States and was certified double Platinum by the Recording Industry Association of America (RIAA).
He then went on to release his sophomore album Exclusive. The album debuted at number four on the Billboard 200, selling 294,000 copies in its first week and has sold 1.9 million copies since, in the United States.
Now comes the release of his third album Graffiti which comes off the heels of his highly controversial troubles with Rihanna. His first single of the album is "I Can Transform Ya", and has peaked at 20 on the Billboard 100. It is definitely a catchy song with its electro-fortified number that clicks, pops and buzzes, but would definitely not hold without featuring Lil Wayne. The only reference made to his troubles would be in the song "So Cold" which makes references as "…and I know I was deadly wrong, but if you see her ask if she will forgive me?". Chris Brown is a talented individual and I feel that he could have demonstrated it more on this album with one or two more ballads. The ballad "Crawl" seemed a little flat to me.
Chris may have won the physical bout, but this time Rihanna has managed to give him a musical upper cut in the battle of the albums.
My Top two picks:
I Can Transform Ya:
Thanks to all my readers! Please leave your thoughts and feedback as to whether Chris or Rihanna has a better overall album. Stay tuned until week!
New Release Music TuesdayPublished December 1, 2009 New Release Tuesday Leave a Comment
Tags: An Honest Mistake, Arlene Grocery, Island Def Jam, Music videos, MySpace, New Music, New Release Tuesday, Sam Endicott, Stinger Club, Stir The Blood, The Bravery
Hello! I hope everyone had a fabulous Thanksgiving holiday filled with fun, food and Great music! This week's pick is a band that caught my interest back in 2005 with their single release "An Honest Mistake".
The Bravery hails from New York and consists of Sam Endicott (lead vocals, rhythm guitar), Michael Zakarin (lead guitar, backing vocals), John Conway (keyboards, backing vocals), Mike Hindert (bass, backing vocals), and Anthony Burulcich (drums, backing vocals). Their music is a blend of both post-punk revitalization and new wave.
The band's early days climbing up the ranks to musical success started out by playing their first gig at the Stinger Club in Brooklyn in November of 2003. They did all the grunt work labels would do by promoting their local shows, manufactured their own posters posters and by handing out 3 song samplers containing the songs "An Honest Mistake", "No Brakes" and "Public Service Announcement" on the Lower East Side of Manhattan and Brooklyn. The band also promoted themselves on the internet and were one of the first bands on MySpace to have a profile. Their MySpace profile pointed to the thebravery.com where the same 3 songs were available as downloadable MP3s.
After several months of headlining and selling out small clubs, the Bravery managed to book a residency at the Lower East side club Arlene's Grocery. The Bravery played every Thursday at 10pm in May 2004. Every show sold out and garnered the attention of many record labels. On August 2004 they signed to Island Def Jam in the United States and Loog Records in the UK.
Since then they went on to release The Bravery (2005), The Sun and the Moon (2007), and their latest released today Stir the Blood (2009).
Their latest release Stir the Blood is a return to their synth-pop and doubling down '80s revival sound. This album is definitely better than their sophomore album that flopped, but not breaking out the shadow of their debut album. I'm not the biggest fan of the new album with it's disturbing lyrics and anger, but I have always liked that 80's new wave pop rock sound! I love the music but I think the lyrics on the album are a bit sketchy. Enjoy my top two picks.
My top two picks are:
Sugar Pill – The video is cool!
Slow Poison:


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Missing Columbia man has been found
False information can cause unnecessary panic and makes work for police more difficult. Sean Heisey, York Daily Record
UPDATE: Columbia PD stated Thursday evening that he has been found.
Previously reported:
Just across the river from York County on Wednesday, Columbia Borough Police were notified of a missing, endangered person, the department said in a release.
William Richard Auliz reportedly left his house on Devonshire Place around 11:30 a.m. and, as of Wednesday evening, has not yet returned. Police were notified at 6:23 p.m.
Auliz is described as a Hispanic male, 5-9, 160 pounds, with black hair and brown eyes. He was last seen wearing a black hooded sweatshirt with diamonds and stars on it, along with dark stone-wash jeans described as baggy. He possibly had a set of headphones on him and was wearing black Nike shoes.
If anybody has any information, they are asked to submit a tip or contact the police department (717) 684-7735.
Related: Jason Knapp, Central York grad missing for 20 years, remembered during memorial service
Related: New look being taken in case where DA Ray Gricar went for drive and 13 years still missing


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A US digital medicine company called Proteus makes 'smart pills' embedded with sensors that tell your doctor when you've taken your medication. The pills also track activity levels.
Backed by big name investors like Novartis, Proteus debuted the first medication made with the technology – a form of the depression and schizophrenia drug Abilify – in 2017.
Now, Proteus is expanding into cancer.
Still, the research on whether the pills actually help patients take their medications when they should remains somewhat unclear.
Would a notification from your doctor as soon as you forget to take your medication help keep you on track?
A digital medicine company called Proteus is betting the answer is yes.
The Silicon Valley-based company makes what have been called "smart pills": essentially, versions of regular medications embedded with a tiny sensor that can be tracked by a patch worn on a patient's stomach.
Since debuting the first medication made with t
Continue reading…


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Alexander Wolff is a writer for Sports Illustrated and former owner of the Vermont Frost Heaves of the Premier Basketball League (PBL).
He has written several books about basketball, among them Big Game, Small World (ISBN 0-446-52601-0), a look at basketball around the world. His most notable and notorious work was a feature article in Sports Illustrated from June 12, 1995, entitled "Why the University of Miami should drop football". In it, Wolff wrote an open letter to then-president Tad Foote claiming that the Hurricanes were a "disease" that had ruined the school's image and needed to be at least temporarily shut down. Wolff wrote a follow up letter in 2011 to the then-current UM president, Donna Shalala, following the Nevin Shapiro booster controversy.[1]
YouTube Encyclopedic
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✪ Alexander Wolff, "The Audacity of Hoop"
✪ Kasseler Stottertherapie - 3SAT Nano


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Spaghetti and Meatballs
A heaping platter of spaghetti and meatballs evokes a feeling of comfort—perfect for a family get-together. The stars of this dish are the meatballs, of course, and they don't disappoint—lots of garlic and Parmigiano-Reggiano give them a robust flavor that stands up to the hearty tomato sauce.
For Tomato Sauce
- 168 Ounce canned whole tomatoes in juice (preferably San Marzano)
- 6 garlic cloves, finely chopped
- 0.5 cup extra virgin olive oil
- 2 medium onions, chopped
- Drain tomatoes, reserving juice in a large bowl. Crush tomatoes with your hands and add to juice.
- Cook onions in oil in pot over medium heat, stirring occasionally, until softened, about 10 minutes. Add garlic and cook, stirring occasionally, until softened, about 2 minutes. Stir in tomatoes with their juice, 4 tsp salt, and 1 tsp pepper. Simmer sauce, uncovered, stirring occasionally, until slightly thickened, 45 minutes to 1 hour. Season with salt.
For Meatballs
- 1 cup olive oil or vegetable oil
- 1.5 Pound ground beef (not lean)
- 1.5 Pound ground pork
- 1.5 Pound ground veal
- 1 Tbsp grated lemon zest
- 0.25 cup finely chopped oregano or 1 tsp dried, crumbled
- 0.33 cup finely chopped flat-leaf parsley
- 2 cup grated Parmigiano-Reggiano cheese
- 6 large eggs
- 3 cup whole milk
- 3 cup torn day-old Italian bread
- garlic cloves, finely chopped
- 0.5 cup extra virgin olive oil
- 2 medium onions, finely chopped
- Cook onions in extra-virgin olive oil in a 12-inch heavy skillet over medium heat, stirring occasionally, until softened, about 10 minutes. Add garlic and cook, stirring occasionally, until softened, about 3 minutes. Transfer to a large bowl to cool.
- Soak bread in milk in another bowl until soft, about 5 minutes. Firmly squeeze bread to remove excess milk, discarding milk.
- Stir together cooled onion mixture, bread, eggs, parmesan, parsley, oregano, lemon zest, 5 1/2 tsp salt, and 1 1/2 tsp pepper until combined. Add meats to bread mixture, gently mixing with your hands until just combined (do not overmix).
- Form meat mixture into about 70 (1 1/2-inch) balls with dampened hands, arranging meatballs on 2 large baking sheets or in shallow baking pans.
- Heat olive or vegetable oil (1 cup) in a 12-inch heavy skillet (preferably nonstick) over medium-high heat until hot but not smoking, then brown meatballs in 4 or 5 batches (without crowding), turning frequently, about 5 minutes per batch. Return to baking sheets.
- Add meatballs to sauce and gently simmer, covered, stirring occasionally, until cooked through, 20 to 30 minutes. (If pot is not large enough, divide meatballs and sauce between 2 pots.)
For Pasta
- 2 Pound dried spaghetti
- Cook spaghetti in 2 batches in pasta insert in boiling salted water (3 Tbsp salt for 6 qt water) until just al dente, draining and tossing each batch with some of sauce in a large serving dish.
- Serve with meatballs, remaining sauce, and grated cheese.
Garnish with grated Parmigiano-Reggiano.
Cooks' notes:
Meatballs can be made and simmered in sauce 5 days ahead and chilled (covered once cool).
Meatballs with sauce can be frozen in an airtight container or heavy-duty sealable bags up to 3 months.
Recipe by Maggie Ruggiero, Gourmet; photo by John Kernick.


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Browsing Tag backpacking
The Backpacking Buzz: Best Travel Tips
Backpacking in a new country isn't about being the most experienced traveler or carrying the heaviest bag. It's all about leaving your schedule behind, hitting the free road and opening yourself to new adventures. Check out our five tips for all types of backpackers below!


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MAN-AT-ARMS & FAKER minis (2014)
When my first set of Masters of the Universe (MOTU) minis arrived in the mail back in March I promptly reviewed them. The cute little things really won me over and I intended to quickly review the 2nd set once it arrived. A new set only comes out every second month so I figured it would be pretty easy for me to stay on top of the reviews. Well somehow 3 sets of minis have been released since that first shipment (with a fifth set will be arriving in a couple of weeks) and I haven't gotten around to reviewing a single one of them. Where does the time go?
I wasn't originally sure if I'd collect all of these little guys. Sure they're cute but they're pretty darn expensive ($15+ per figure when you factor in the shipping! Eek) and more importantly, I don't really NEED them. If these were the only MOTU figures available then I would NEED them but because the Classics line already does an excellent job of getting me my monthly He-Man fix these mini figures are nothing but incidentals to my true MOTU collection. But I'm a sucker and so I keep buying them. If the inaugural set of minis had included He-Man and Skeletor, as one would've expected, I probably wouldn't have bought it and could have maybe avoided this whole can of worms. But because Mattel paired He-Man with my favorite MOTU character Mer-Man in that first set I couldn't help but buy it and thus get hooked on these stupid little things.
The second set included Moss-Man and Skeletor, the third Scareglow and Stratos, and this fourth set contains Man-At-Arms and Faker. The fifth set will bring me Zodak and Beast Man. In my opinion, this fourth release is these least exciting of all the sets. I was never a big fan of He-Man's evil android doppelganger Faker and Man-At-Arms is just a dude with a mustache and a half-suit of armor. He's still a cool character, and a vital one, but he's pretty boring when compared to the other Masters and Evil Warriors. I would've much preferred to see a Buzz-Off & Mantenna 2-pack for example.
While Man-at-Arms and Faker may not be my favorite MOTU characters they're by no means bad characters. I don't think there's a single "bad" character in the series. And these 2 figures are excellent versions of these characters.
Man-at-Arms is one of the core characters that I'm missing from the Classics line so this little guy is actually my only modern Duncan figure (Duncan's his real name). I hope to eventually acquire a Classics version but if I don't then I guess I'll have to display this figure as my primary Man-at-Arms. I'll just pretend that Skeletor cast an irreversible shrink spell on him. The sculpt is great with loads of little details. He's got his big burly signature mustache and an angry scowl on his face and fur-lined armor full of wires and rivets. For accessories he has his trusty vintage-era club as well as the detachable blue arm cannon from the 200X version. Like all of these figures he's top heavy but he's posed in such a way that he stands on his own just fine. I'm painfully aware of how tough it can be to get action figures to stay standing and I'm blown away by how sturdy these mini figures are.
For He-Man's evil clone Mattel could have taken the easy way out and just re-painted the already released He-Man figure but they didn't, they sculpted a whole new figure for Faker. This is a great little figure with loads of personality. As with the mini-He-Man I think I like this version of Faker better than any previous versions. I'm not sure why but He-Man and Faker work really well in this stylized format. Faker includes an orange power sword and battle axe.
This set included a crucial piece of the build-a-playset Castle Grayskull, the Jaw Bridge, which can be opened and closed. My mini castle has grown from a pile of stray pieces into a legitimate fortress which is nearing completion. It's gonna look great once it's finished.
It's hard to recommend these figures when you consider the price but if, like me, you're ordering figures from mattycollector.com on the 15th of every month anyway you might as well throw these guys in your virtual shopping cart as well. They're cool and adorable. 8 out of 10.
Posted on October 22, 2014, in Master's of the Universe and tagged Action Figure, Masters of the Universe, Review, Toy. Bookmark the permalink. 2 Comments.
Man these are great! Theres just something about taking a regular size figure and mini-sizing them that attracts me. These look they have a lot of personality thats for sure!


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MOTORCADE are a band from Dallas, Texas whose members have worked with the likes of St. Vincent, The Apples in Stereo, The War on Drugs, The Deathray Davies, Baboon and Daniel Johnston. They have now have joined together to make their debut album proving that the whole is definitely greater than the sum of their parts.
Listen to "Deliver"


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It's ridiculous that in a world where so much is spent on mobile phones, there are people struggling to eat.
Last night we attended the Luton & Bedfordshire Community Awards night with young nominee Dirk Withnail.
Back in the summer, Dirk hiked 139km, raising nearly £1000 for Luton Foodbank. We're delighted to tell you he was named Young Hero of the Year! Very well deserved it was too!
Well done Dirk, and thank you for your efforts!


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A Confession – Longing for Joy.
I wish I had a glorious word on joy. Instead I have a confession. My joy has been complete. I have sung in joy for what the Lord has done. I will gather with others and do this today. I will sing songs of our salvation and His promise to be with us even now, and in that moment, I will know the joy of my salvation. But this Advent, day to day, joy has weighed heavy before me. Each night we sing our Advent family song, "O Come, O… Read more A Confession – Longing for Joy. →


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So... I'm working on trying to move from basic Python to some GUI programming, using PyQt4. I'm looking at a couple different books and tutorials, and they each seem to have a slightly different way of kicking off the class definition.
One tutorial starts off the classes like so:
class Example(QtGui.QDialog):
def __init__(self):
super(Example, self).__init__()
Another book does it like this:
class Example(QtGui.QDialog):
def __init__(self, parent=None):
super(Example, self).__init__(parent)
And yet another does it this way:
class Example(QtGui.QDialog):
def__init__(self, parent=None):
QtGui.QWidget.__init__(self, parent)
I'm still trying to wrap my mind around classes and OOP and
super() and all... am I correct in thinking that the last line of the third example accomplishes more or less the same thing as the calls using
super() in the previous ones, by explicitly calling the base class directly? For relatively simple examples such as these, i.e. single inheritance, is there any real benefit or reason to use one way vs. the other? Finally... the second example passes
parent as an argument to
super() while the first does not... any guesses/explanations as to why/when/where that would be appropriate?


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UC to offer support to applicants affected by natural disasters
In an effort to assist freshman and transfer applicants affected by the deadly wildfires that have scorched large stretches of California — as well as by the recent spate of other natural disasters — the University of California will extend its fall 2018 application deadline to December 15 for affected students who may need additional time to complete the application process.
UC remains committed to ensuring that fall 2018 applicants affected by the recent natural disasters receive the support they need during this difficult time.
Detailed information on how to request an extension, along with additional important advice, is posted here:


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UK's Goan Hub of Eastcott Swindon Gets Indian-Origin Councilor
Swindon is home to roughly 20,000 Goans, many of whom moved to the UK after applying for Portuguese citizenship.
Eastcott Swindon, a UK town home to roughly 20,000 Goans, elected its first Indian-origin borough councilor on May 3, the Times of India reported. Imtiyaz Shaikh, who contested as a Labour Party candidate, won with 1,621 votes while his closest competitor in the five-cornered contest for the seat, Toby Robson from Liberal Democrats, got 1,344 votes.
"Now that I've won, my aim is to listen to issues local residents face and try to find solutions while maintaining an honest and open relationship with the council and fellow councilors," Shaikh, 37, told the publication after his victory. "I came to London in 2005 with a dream of making something out of my life, with the opportunities the country offered. My experiences during the last 13 years have been nothing but positive, living in a country that embodies unity through diversity," he added.
Shaikh moved from Vasco da Gama to the United Kingdom about a decade ago. The father of two finished his education at St Joseph's Institute, Vasco, and then worked at Western Union Shipyard Ltd.
Understanding the need for a representative for the Goan diaspora in local politics of the area, Shaikh contested on a Liberal Democrat ticket in 2014 and subsequently, on a Labour party ticket in the recent elections. The Labour Party, he said, has always "stood by and supported immigrants and worked towards a fair and open policy for all."
Shaikh is among several councilors of Indian origin to be elected in the local elections for boroughs in London, Leicester, Birmingham and Manchester, the Hindustan Times reported. The borough council is a section of lower government, which looks into council tax collection, housing, planning applications, waste management and recycling.
Shaikh, who served as a secretary of Vasco da Gama Swindon Community, is a leading member of Swindon's fairly large Goan community. Many of the Indian-origin residents in the area are said to have reached here through a provision in the UK law, which gives citizens of the European Union the right to live and work in the country. Goa was a Portuguese colony, and according to Portuguese nationality law, people born in the Indian state before the end of its colonial rule in the state on Dec. 19, 1961, and their next three generations, can claim Portuguese citizenship after registering their births in Lisbon.
About 28,000 Portuguese residents of Indian origin lived in the United Kingdom as of June 2017, according to the Office for National Statistics. The number has surged from 13,000 in June 2014 as the community made Swindon, a town nearly 130 km southwest of London, their hub. A small population lives in London and Leicester as well.
The "backdoor" immigration of Goan-origin Portuguese nationals has been a matter of criticism and debate for years. The Oxford University published a study in 2015, that illustrated how Portugal became the biggest gateway into the United Kingdom for tens of thousands of immigrants born outside the European Union.
There had been much uncertainty over the status of Goan-origin Portuguese nationals post-Brexit as they had been living in the United Kingdom as European Union citizens in the country. The uncertainty compounded over the recent Windrush scandal, regarding forcing members of the "Windrush generation" to leave the United Kingdom in order to meet net immigration targets.


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Learning the Basics |Piloting the Deep Trekker DTG2 ROV
Welcome to the first of many video tutorials by Sam and Amanda. When we are at trade shows we bring one of our giant water tanks, so that you can have a first hand piloting experience of the Deep Trekker DTG2 ROV. But people have been asking us, what about those that can't come to one of our trade shows to see the Deep Trekker in action?
Well, you asked, and we have answered with this video showing you the basics of how the Deep Trekker DTG2 ROV maneuvers using our hand-held controller. Our goal was to make an ROV for everyone and part of this was making the Deep Trekker DTG2 dead simple to operate. With only two joysticks and two thrusters, our patented pitching system allows the Deep Trekker ROV to be the most maneuverable and easy to use ROV on the market.
Want to know more about the DTG2? Email us with your request.
Continue to watch for more informative and fun videos coming your way so you can get to know the Deep Trekker products, the Deep Trekker team, and many tips & tricks.
Related Resources
Get to Know Deep Trekker ROVs | Frequently Asked Questions
Get to Know Deep Trekker ROVs | Frequently Asked...
ROV Thickness Gauge: The Attachable Tool for Hull Inspections
ROV Thickness Gauge: The Attachable Tool for Hull...


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Not what I expected
This is a very beautiful elegant looking spacer, very detailed and shiny with sparkling stones. The only thing I wished is the dangle itself was a bit more larger, it is almost invisible had I known this before purchasing I probably wouldn't have. But non the less it's still a pretty unique spacer and for the price you just couldn't pass up


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Complete shutdown in Occupied Kashmir against new military camp by Indian Army
SRNAGAR - In occupied Kashmir , the Joint Resistance Leadership has called for a complete shutdown on Monday when India is going to stage a drama in the name of municipal and panchayat elections in the territory.
According to Kashmir Media Service, the leadership comprising Syed Ali Gilani, Mirwaiz Umar Farooq and Muhammad Yasin Malik while issuing protest calendar asked people to observe the shutdown to express their resentment against the election ploy.
The leaders said that as part of Doval doctrine, an attempt is being made to thrust an exercise in the name of elections on the people of Kashmir to break their resolve for standing up against India for their fundamental right.
Meanwhile, complete shutdown was observed on the sixth consecutive day today in Kulgam district against the establishment of a new army camp at Redwani.


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Indian Wedding in Ravello
They were both about 70 year old, he was wearing casual shorts, white snikers, gray curly hair and shirtless walked hand in hand with his beautiful wife.
Not so young, I thinked, then I turned my head to the other hand, framing me clients.
I continued my work, smiling inside.
We are in Amalfi for a pre wedding photo service to J. and M. that in the afternoon, they were married in Ravello, Amalfi Coast.
About this marriage I can only tell some details, like the pictures that I will publish.
J and M are a shine couple that asked me to maintain their privacy and so I will do.
But I'll tell you about the wonderful day I spent with them.
In the morning of August 27th, we went to Amalfi for a pre-wedding shooting. Amalfi is a stunning location.
Walking the beautiful streets, I seem to recognize even Steven Spielberg (the director!) walkng around, he noticed me just beacuse I was whit my big cameras, he must have thought I was a paparazzo, of course I didn't photograph him and he went away quiet and relaxed .
Then, I read that in those days he was on the coast with his family.
Anyway the story I want to tell you happened during this shooting.
Walking near the port we met an aged couple about 70/75 years old, the grey curly hair man was holding the hand of his wife walking towards the sea.
You would see their love just from far.
J. wanted to take a picture with them, we became friends in one minute and they told us they were in love from 50 years like the day one, after a few funny anecdotes and a few bars we went on.
The beauty of my job is the unexpected events like this, the candor in telling us their feelings after so many years together hit us all, and especially J. and M. . On that day they would be married.
J. and M. were married in a civil ceremony in the gardens of the Principessa of Piemonte and then they had the dinner and the party at the Belmond Hotel Caruso, one of the most beautiful places in the world, the view from the terrace right on the coast, the aperitif among the olive trees, the long table that seems designed by an artist.
Everything was perfect, the party was intimate and funny .
At the end of the evening we moved to the pool where they danced traditional indian dances but also some romantic songs.
A few images:
Wedding photographer in Ravello, Amalfi Coast
Please visit my Amalfi Coast Weddings Page for more informations.


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Diogenes wrote:KitemanSA wrote:I suspect it is more like X^Y where Y>1, probably >2. As a deterant, the quantity of "getting smoked" has a quality all its own.Diogenes wrote: [I think for every number "X" of bad guys who get smoked by an armed citizen, the deterrence effect is X+Y, with Y being a non negative number. There are a lot of criminals who decide not to take the chance when they hear that criminals are getting shot.
Lest I be thought of as "unreasonable", I was being cautious with my numbers. I agree with your numbers.
Kind of makes one wonder....what is the contrary "multiplier effect"? That is not so many years ago, if you shot someone under similiar circumstances alot of places(like Britain today), you would be crucified by the media. You not the criminal you defended yourself against would have been the villian. If they were unable to legally convict you for murder/manslaughter, than miraculously the relatives of the deceased criminal would have no trouble finding lawyers to sue you into bankruptcy. Wonder if that tended to embolden criminals? Again one of those kinds of things that are tough to quantify....the rape/mugging that happens when bad guys read about citizens pilloried by the authorities(& media) when they defended themselves, and they take heart & are encouraged by that. Like what happened to Bernard Goetz years ago. http://en.wikipedia.org/wiki/Bernard_Goetz


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Teachers are able personalize blog settings for each individual class.
To personalize your settings, just follow these steps!
Select "Blog" on the right hand side of your screen.
Select "Class Feed"
Choose the desired class from the drop-down list.
Select the gear icon and toggle the options to allow or disable specific features. When you are finished, select Save.


text: Overview Price: ₱ 6,000,000 Rent Sale Property Type: Townhouse Lot Area: 68m2 Floor Area: 96m2 DescriptionDetailsCity / Municipality: Quezon CityProperty ID: TH0723180051 Foreclosed New Resale Meter Frontage: 0m2Bedrooms: 3Bathrooms: 2Car Garage: 1 Furnished Townhouse for Sale in Tandang Sora 2-storey Residential Unit Investment Price: 5.5M 30% Down payment amount : 1,800,000.00 Balance: 3,850,000.00 Estimated Monthly Amortizastion 5 yrs : Monthly Payment : 79,259.18 10 yrs : Monthly Payment : 44,547.52 15 yrs : Monthly Payment : 33,213.33 For viewing or reservation, feel free to call us on numbers displayed. We provide free bank financing assistance. Notes: Price & terms are subject to change without prior notice. Loanable amount is subject to bank approval. Please consider transfer expenses and bank charges (if applicable) For viewing and reservation, please call the numbers displayed. With Income?: No Home Features Balcony Built-in Cabinet CCTV System Electric Fence Electronic Gate Elevator Fire Sprinkler Fireplace Jacuzzi Lanai Smoke Detector Swimming Pool Facilities & Amenities 24-hour security Adult Swimming Pool Basketball Court CCTV Surveillance Centralized Mail Room Club House Electronic gate Elevator Entertainment Room Fitness Gym Function Hall Gazebo Jogging Path Kiddie Pool Landscaped Gardens Mini-theater Multi-purpose Hall Overhead water tank Perimeter Fence Playground Rooftop helipad Sauna School Shuttle Service Standby power generator Tennis Court Underground cistern View deck


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Kid Trainer Demarjay Smith Will Guest Star on 'Henry Danger' & 'Game Shakers' Crossover!
Ellen DeGeneres loves to give surprises — and this surprise is one of the best!
The host brought kid trainer Demarjay Smith from Jamaica back to her show to catch up with him about his latest adventures and new motivations.
After sharing some good news of his own where he's headed to Japan to shoot some commercials, Ellen gave Demarjay even more good news — he'll be guest starring on the new crossover between Game Shakers and Henry Danger!
While we don't know all the details of the crossover yet, JJJ is really excited to find out more!
Kid Trainer Demarjay Is Back!
Posted to: Demarjay Smith, Game Shakers, Henry Danger, Television


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shopping basket0 item(s) - $0.00
ideal for
• furniture • ornaments • walls • painted surfaces • paper • fabrics • most porous surfaces
unique qualities
• water based • low odour • dries quickly • washable surface when dry
at a glance product info
application and advice
Ensure product is well mixed and that all surfaces are clean and free from grease, oil, dirt and contaminants.
Roller application: Pour into shallow roller tray. Fully load a smooth, gloss roller and apply evenly using light pressure to achieve an even coverage and distribution of glitter.
We recommend familiarising yourself with the effect on a small test area before starting work.
Do not apply over oil based products. Acrylic coatings may draw stains through latex paint.
Protect from extremes of temperature during storage and application. Ensure complete mixing after standing for long periods of time.
health, safety and the environment
Non-hazardous. Ensure good ventilation. Keep out of reach of children. Contact with eyes – wash immediately with warm water. Remove excess from tools and mixing vessels before washing in warm soapy water. Do not empty containers into drains and watercourses.


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Life with multiple sclerosis (MS) is never dull or boring. It's often filled with surprises, some of which are not very pleasant. Learning to be adaptable to sudden changes is a highly desirable skill, yet even with my 10 years of practice, I find that it can still be elusive.
Robynn and I try to schedule our blogs a few weeks in advance. It allows us to adjust them if a major news story breaks or if something in our personal lives interferes with our writing schedule. Following our very successful discussion with Meredith Vieira, we planned to conclude 2014 with an MS Year in Review column.
"Planned" is the key word. Shortly after outlining our work, I began having periods of extreme fatigue. Since I am living with both MS and narcolepsy, I am no stranger to disabling tiredness. But this was over the top in its intensity, and we were forced to hold off writing this topic.
The Blog That Never Happened
Fortunately, as we approached the new year things began to improve. We started compiling research to write a new column about exciting new MS treatments that await us in 2015. But MS had other plans for me: Debilitating spasms in my back landed me back in bed. My neurologist prescribed a rescue medication that is very effective in controlling these painful attacks.
As with all medications, you have to weigh the side effects against the potential benefits. Since the pain was intolerable, we readily accepted the sleepiness that came along with the treatment. Unexpectedly, whether due to the medication or the MS flare-up, the sleepiness was accompanied by moodiness that left me in no position to write. Another column had to be scratched.
MS Flare-Ups: It's Not My Fault
Like so many of us living with chronic illness, we often find fault with ourselves when our health challenges interfere with the performance of a task.
After having being forced out of the workplace due to MS, writing this column became a major source of personal accomplishment for me, and it's been a way to connect with so many interesting people.
Not wanting to jeopardize this experience, I began thinking that if I had only rested more or eaten more nutritiously, none of this would have happened. Sure, those things help, but I was already doing both. That is when the reality slapped me in the face. We are living with MS and flare-ups are to be expected. The only thing we can truly control is our reaction to the never-ending series of obstacles MS will place in our way.
A Planner's View of the World
Many of us are now testing our ability to follow our resolutions for the new year. It is my nature to be a planner. Even my chosen career as an accountant was a very analytical vocation. The events of the past few two months have strengthened my resolve to be flexible in my plans and make the best of a given situation.
In that spirit, we wish you and your family the very best of health for 2015!
Photo: Shutterstock


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- Track Order
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Australia's BIGGEST Weddings & Party Sale STARTS NOW! Hurry, while stock lasts! >Shop Now
Baby Owl Large Party Stickers (Set of 24) - Custom Printed
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Have you checked out our personalised wedding & party supplies? Make it special with the gorgeous customised invitations, decorations & favours. Shop here.
Treat guests in style to your baby owl party, christening, naming day or baby shower with these sweet personalised party stickers. Features and facts:
- These sweet party stickers are personalised just for you - you let us know what text you want us to print and we will create you a unique and stylish party favour that will wow your guests.
- Our owl labels are in sweet pastel colours - choose from pink, blue, yellow, green, peach or lavender.
- We love these stickers for baby birthday parties, baby showers, and naming days.
- Our stickers measure 4.5cm diameter - perfect to put on a lollipop, a party bag, stick back to back on a lollipop stick as a food pick or cupcake topper, or simply as a really fun label for your party loot and treats.
- On the sticker you have four lines of text:
- Text Line 1 maximum of 14 characters
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- Our stickers are sold in sets of 24 personalised labels.
- Personalised labels take 14 days to be delivered to you. If you require a rush order, please choose express shipping to upgrade your order to a 2-5 day delivery.
- Mix and match with our other personalised baby owl themed favours, party labels, stickers, thank you cards and decorations to create the perfect owl themed soiree!


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Considering PayPal is one of the world's biggest websites, their navigation remains one of the worst as far as I'm concerned. I just spent the best part of an hour trying to find where the repeat payments, or subscriptions section was and it was nearly impossible.
I can only assume that PayPal have deliberately made it difficult to find the subscriptions page on your account so that people can't find it, and thousands of payments continue to go through, making PayPal a huge sum of money each year.
As I sell online, I have subscriptions set up to pay me, and it's therefore extremely important for me to keep a track of what subscription is due, and which ones have been cancelled.
Some time ago, PayPal redesigned the "profile" section of their site, which seemed to me to make things even worse when trying to locate information.
There are two different sections in Payal, firstly the My Approved Payments section, which outlines businesses or individuals who have a Direct Debit set up on your account, just like perhaps your mobile phone company, who take a different amount direct from your account when a payment is due. You have to sign up for these, being a seller on Ebay is the most common one, once a seller has sold something on Ebay, they will deduct your PayPal account with the sellers fees.
The My Approved Payments can be found by clicking the following route :
My Account (on main navigation bar)
Profile (navigation bar below My Account)
My money (left hand side navigation menu)
My pre-approved payments (on the right hand side click Update)
C'mon PayPal, those four links to get to that page are all over the place, you are a huge business, you can make it easier then that to find something.
The other section which is even more impossible to find is Recurring payments dashboard. Recurring payments are slightly different in that they are subscription payments, something you regularly pay the same amount for on a set date.
Being PayPal, they have named this page "Recurring payments dashboard" but called the link to it "My automatic payments".
The My automatic Payments (or Recurring payments dashboard, or Subscriptions) can be found by clicking the following route :
My Account (on main navigation bar)
Profile (navigation bar below My Account)
My selling preferences (left hand side navigation menu)
My automatic payments (on the right hand side click Update)
Then you'll be able to see the Recurring payments dashboard which shows Subscriptions, Automatically invoiced payments and Instalment plan payments. The next useless part of it is that you can only see 25 of them at a time, which is crap if you have several hundred set up and you're looking for one created 2 years ago.
PayPal must realise this navigation is so poor, their search box returns no help at all.
I hope this article helps if you're trying to find a list of subscriptions on Paypal.


text: This month I have been seriously lacking in the posting and updating department. There is only one thing that can keep me away for so long. NETFLIX. Seriously, this month I have been Netflix and chilling so hard. I have not gotten much of anything done. Besides the usual work and family time. There are … Read More


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Breath of Fresh Air
Living in metropolitan cities often entails getting constantly choked by fumes and toxic emissions. We can call it the norm in the sophisticated urbanized world or simply term it pollution at its worst. Continued exposure to such harsh living conditions leaves most everyone drained, and this is not just at the end of the day either. Many people complain of fatigue and stress all through the day, even beginning as early as a couple of hours after rising from bed.
The frequency of disorders like anxiety, asthma, bronchitis, stress and migraine is rising at an alarming rate. Research shows there is evidence that suggests that our bodies can develop immunity against the harmful effects of urbanization simply by breathing in fresh air right from the nature. Not only does this relieve conditions like stress but it also improves the cognitive functions of the brain.
Now, there rises the question, how can one live in the city and have access to air filled with the goodness of nature. Well, if we can't live amidst the nature, then let's bring plants and the nature closer to us. One can do this by planting a kitchen garden, arranging flower pots and opting for lush green landscaping to transform ones homes and work spaces. Do away with concrete and welcome rich soil for growing the green cover. Plant saplings and conserve trees.
And if you don't want to go through that hassle, Sanicon brings you a solution with Initia. Initia is beautiful integration of nature's goodness, bringing together the wild abandon of waterfalls and lush majestic of plants. It is simply a picture of your imagination. It could be a vertical green wall with water curtains, a water fountain with plants, or even a portable fountain that runs of waste water from your sinks, water purifiers (ROs) and air conditioners (ACs).
Initia is based on the ideology that running water calms our brains and soothes our nerves whereas the lush green plants purify the air and create an ambiance of harmony. Together, this helps in improving our sleep cycle and creating a positive aura within our living spaces, be it your home or office. What are you waiting for? Freshen up the air you breathe in. Book yours today.