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Extradural hematoma
Road trafic accident
Patient Data
Age: 23-year
Gender: Male
From the case: Extradural hematoma
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CT scan shows biconvex epidural hematoma over the right frontal lobe which is homogenously hyperdense. There are evidence of midline shift and subfalcine herniation. A fracture line is noted at the right temporal bone as well.
Case Discussion
Extradural hematoma is one form of extra-axial collection. It is usually associated with trauma, the shaped said to represent a lemon, as opposed to a banana appearance with a subdural hematoma.
In 95% of cases a underlying fracture is present.
- Sullivan TP, Jarvik JG, Cohen WA. Follow-up of conservatively managed epidural hematomas: implications for timing of repeat CT. AJNR Am J Neuroradiol. 1999;20 (1): 107-13. AJNR Am J Neuroradiol (full text) - Pubmed citation


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How To Decorate Your Home Alone
A lot of the modern day homeowners would try everything possible to ensure that they ensure that their homes have such a perfect touch that they have always wanted. And it can be one of those investments that will take much of your time and resources.
It can be costly when you have to pick someone to do the job for you. Here are a few tips that can help you decorate your home on your own.
The first thing that you do is to create geometric carpet types. You can find a simple rug and apply a paint to make it attractive. You need to design something that is unique. And you need to be careful when picking the carpet types that you want. The carpet types that you pick matters a lot.
And since you are the one designing your carpet types, you will not want to pick a rug that will not take the paint well. You need to come up with carpet types that are both attractive and reliable.
And if you have old necklaces that are no longer meaningful to you, you should not throw them away; you can use them as your tiebacks. They will look appealing on your curtains. Quite simple things that can offer you an amazing room.
You may also need to decorate your door as well. You can make use of ceiling medallions. However, you need to know the size of your door before you buy the medallions that you need. You need a medallion that will fit your door well. You will be fixing the medallion on your doorknob. These medallions are best for centered door knobs.
You should also find a contrasting trim. A contrasting trim ought to be at the top of your decorating tips. What's more, it is relatively easy and makes a big pop.
When you design an architectural detail and introduce such a bold paint; you can get such an amazing effect. The colors that contrast but complement are great. Ideally, you need to pair light colors with the dark ones.
You also want to consider the articles that you will put on your room. There are many artistic impressions that you can create with paperclips, glue and your Pinterest. What is crucial though, is you would want to know what things you need to highlight. And you need to create something that will offer you the right statement. You need to consider the kind of stories that you will want to share on your artwork.
Then there is the sunburst mirror. You need a round mirror that has a lot of Gorilla glued on its wood shims – it will look remarkable.
You may also have to create a shutter side table. It is one of those great projects. The junk wind chimes are also things that you can create on your own.

subset: commoncrawl


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It's been a full couple of weeks. I haven't been around, on account of my noes being firmly stuck in a flash file, along with life throwing a couple of those curve balls at us. Sigh, so I decided it was time to come out of my shell for a bit, smell the fresh air, look around a bit... Thankfully the local fire fighters have my back on this one. Yup... that's me on top of that ladder.
And here's the view from the top this week...
Wednesday, June 18, 2008
The View From Up High
Posted by AlpineButterfly at 6:40 PM
1 comment:
- Judith HeartSong said...
woo hoo for you!
- June 22, 2008 at 6:07 AM
Subscribe to: Post Comments (Atom)


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SHREVEPORT, La. – After a tough loss by the Ladies to Texas Lutheran (9-21, 6-10 Southern Collegiate Athletic Conference) in five sets, 11-25, 25-21, 22-25, 25-13, 15-12, Centenary (16-17, 7-9 SCAC) rebounded for a four set win against Schreiner (3-27, 2-14 SCAC) 23-25, 27-25, 25-21, 25-20 Sunday afternoon, October 28.
After losing a tough match in five sets to the Bulldogs, the Ladies lost the first set to Schreiner and trailed 24-23 in the second. Freshman Lauren Kelley recorded a kill to repel one set point, but a kill from the Mountaineers gave the visitors another set point. Kelley tied the set back up with a kill, and two kills from senior Michaela Brantley tied the match.
Kelley finished the match with 16 kills and three errors on 30 swings (.433 hitting percentage).
Centenary trailed 17-13 in set three, but a 10-1 run put the Ladies up. After a timeout, freshman Elizabeth Epley got a kill. An attack error and an assisted block by Epley and freshman Rachel Demejian brought Centenary within one. Both team sided out, and another Epley kill tied the set. Senior Shyann Pisano hit an ace and an attack error brought Centenary to 20. Two aces by Pisano and another error by Schreiner put Centenary up five. The Ladies went on to win the set by four.
Centenary led by as much as six in set four, but Schreiner rallied to pull within 22-19. That is when junior Kristian Loving recorded a dig off a Schreiner attack that went over the net that fell in for a kill. A Demerjian ace put Centenary on set point. Both teams sided out as Centenary won in four sets to qualify for the SCAC Tournament for the second consecutive season.
Brantley recorded 10 kills while Demerjian finished with the double-double with 47 assists and 15 digs.
Schreiner trailed 22-19 in the first, but scored three straight to tie the set. Alexis Coronado and Bianca Olivares recorded kills and a solo block by Amanda Combs tied the set. After both teams sided out, a Coronado kill put Schreiner on set point. A Coronado kill gave the visitors set one.
Coronado finished with 13 kills and 21 assists, while Combs added 10 blocks. Schreiner stayed close to Centenary thanks to a 15-4 edge in blocks.
In match two, Centenary led 17-10 in set one before and 8-1 run gave the Ladies first frame. After a Brantley kill, two errors and an ace from junior Marissa Sandoval increased the lead to double digits. After both teams sided out, two aces from Loving and a kill from freshman Alyssa Davis gave Centenary the first set.
Davis finished with 12 kills, while Sandoval added 33 digs.
Texas Lutheran claimed set two and four, while the Ladies took set three as the two teams went to the fifth.
In the fifth set, Centenary held a 5-4 lead before four straight by the Bulldogs. Centenary hit an error and three kills from Savannah Kitchens put Texas Lutheran up three. The Bulldogs went on to win the set by three.
Peyton Sulak led Texas Lutheran with 14 kills and seven blocks, while Kelly Juden added 44 assists and 20 digs.
Centenary, the fifth seed in the upcoming SCAC Tournament, will take on host Dallas Friday, November 2. The first serve in Irving, Texas, is set for 3:30 p.m. However, the Ladies finish the regular season Tuesday, October 13, at Jarvis Christian. First serve in Hawkins, Texas, is set for 6 p.m.


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Reza Zarrab's First Hearing to be Held in US in January 2017
- Written by Admin TOA
- Published in Businessman
- 0 comments
(MENAFN - The Journal Of Turkish Weekly) A U.S. court has ruled to start the trial of Reza Zarrab, an Iranian-born Turkish businessman who was arrested in Miami in March for attempting to evade U.S. sanctions on Tehran, on Jan. 23 next year. The decision on June 20 came after U.S. District Judge Richard Berman in Manhattan denied bail on June 16 to Zarrab, who had applied to live in a lavish Manhattan apartment on a 50 million bond with private armed guards before going on trial.
The 10-minute hearing on June 20 was set to take place on June 16 but it was postponed after Judge Berman accepted U.S. Attorney Preet Bharara
Last modified onWednesday, 24 May 2017 09:49


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A reverse stock split is when a company decreases the number of shares outstanding in the market by canceling the current shares and issuing fewer new shares based on a predetermined ratio. For example, in a 2:1 reverse stock split, a company would take every two shares and replace them with one share. A reverse stock split results in an increase in the price per share.
A stock split, on the other hand, is when a company increases the number of shares outstanding by splitting them into multiple shares. This results in a decrease in the price per share. In a 2:1 stock split, each share of stock would be split into two shares.
Are There Typical Ratios For Reverse Stock Splits?
Common share swap ratios used in a reverse stock split are 2:1, 10:1, 50:1, and 100:1. There is no set standard or formula for determining a reverse stock split ratio. Ultimately, the ratio chosen depends on the stock share price that the company ultimately wants its shares to trade at on the exchanges.
Example of a Reverse Split
A company announces a reverse stock split of 100:1. All investors will receive 1 share for every 100 shares they own.
So if you owned 1,000 shares at a stock price of 50 cents per share before the reverse split, you would own 10 shares at a price of $50 each after the reverse split. The value of your holdings was $500 before the split (1,000 shares at 50 cents each) and $500 after the split (10 shares at $50 each).
However, some investors can be cashed out of their positions if they own a small number of shares. For example, if an investor owns 50 shares of a company that splits 100:1, the investor would be left with only half a share, so the company would pay that investor the value of the 50 shares.
A reverse stock split causes no change in the market value of the company or market capitalization because the share price also changes. So, if the company had 100 million shares outstanding before the split, the number of shares would equal 1 million following the split.
Why Would a Company Do a Reverse Split?
1. To prevent its stock from being delisted by boosting its share price. Being listed on a major exchange is considered an advantage for a company in terms of attracting equity investors. If a stock price falls below $1, the stock is at risk of being delisted from stock exchanges that have minimum share price rules. Reverse stock splits boost the share price enough to avoid delisting.
2. To boost the company's image. Typically, stock with a share price in the single digits is seen as risky. As its price approaches $1, a stock may be seen as a penny stock by investors. A company may try to protect its brand by avoiding the penny stock label and engage in a reverse split. There is a negative stigma typically attached to penny stocks traded only over-the-counter.
3. To get more attention from analysts. A company may not be in danger of being delisted, but it may nonetheless wish to increase its share price to attract more attention from analysts and investors. Higher-priced stocks tend to attract more attention from market analysts.
4. To avoid delisting from options exchanges. Typically, a company's share price must be greater than $5 for options to be traded on the stock. If a company's stock price falls too low for options to be traded on it, the shares might lose interest from hedge funds and institutional investors who invest billions of dollars in the market and hedge their positions via options. If portfolio managers can't hedge their long positions (due to delisting from an options exchange), they may sell the stock.


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Robinsons Land Corporation is now accepting reservations for the third tower of its leisure development in Mactan. Amisa Tower C is 18-stories. Interested buyers can choose between studio or 2 Bedroom units. The price range is 3.3 to 8.1 million pesos. For more information check out: Amisa Resort Community Updates
You may also contact an In-house Sales Group to get more details about the project.


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Vitafusion Gorgeous Hair Skin & Nails Raspberry Gummies
135 ctUPC: 0002791702006
Purchase Options
Located in Aisle 32 in Your Store
Beauty Is The Fruit Of Wellness
It lives in every cell of your body when you feel your best. So we've created a clever fusion of nutrients to help feed your body beautiful nutrition and achieve beauty from the inside out.
Some search high and low for the best-kept beauty secrets, but with Vitafusion™ Gorgeous Hair, Skin & Nails Multivitamins, it's really quite simple.
- We Make Nutrition Taste Good™
- Multivitamin Plus Biotin & Antioxidants
- Natural Raspberry Flavor


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As part of our commitment to providing quality services at residential pricing, ISPAfrika has now dropped its pricing to all Century City Customers. Along with our Free Wi-Fi router we are providing both capped and uncapped services.
Century City
One Comment
Hi century on Lake in century city is completed. Looking for ISP Provider. Can you please provide m with fiber packages uncapped. Thanks Sheena


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A couple decides to get married because they love and care for each other deeply. However, there are times when relationships don't work the way they want it to, which often leads to massive fights and misunderstandings.
Going through such a relationship can affect a person's understanding of what a relationship should be. They even feel skeptic about it and would often feel afraid to have another intimate connection with someone.
But, if there's one good thing about love, it's that it always finds a way to get into a person's heart. No matter how bad a person's experiences are with their past relationship, they're bound to meet someone great at one point in their lives.
Getting remarried can be scary, but the joy you'll feel once you have the right person in your arms will surpass all the doubt and hesitation you sense now. Consequently, is your relationship worthy enough for you to leap into remarriage? To help you make the right choice, here are a few questions to ask before you get into another marriage:
"Am I doing it for the right reason?"
Some people think that having kids is enough reason to stay unmarried. Although there is some truth to it, divorced people have other reasons to get married. Some couples choose to get remarried to strengthen their bond if they're already living together.
Meanwhile, others feel like marriage is right for them as a couple. Whatever it may be, ensure that you're doing it for the right reason. Choosing to get remarried because you're afraid to live alone or you're looking for someone to support your financially won't make your relationship last.
"Are my kids okay with my decision?"
Even the best couple will have problems blending their families. Even Chicago Tribune says that doing it can be complicated and painful at times. Before you decide to tie the knot again, ensure that your kids are okay with it. If you feel like your kids aren't comfortable with the idea, you might want to take things slow.
Although it doesn't mean that you'll never get to marry the one that you love, taking things slowly will give your kids enough time to think about it. Psychology Today says that forcing the idea of marriage to your kids might cause your children to choose between you and your former partner. They may feel disloyal with their dad if they start calling your new partner the same thing. Try to work with your children first and see how it works.
"Is it the right time to get married again?"
Going through a second marriage to recover from your first marriage won't make your relationship last. Even if you're done dealing with your divorce lawyer in Utah County, it's still best to think things through before you decide.
Don't believe that your second marriage is doomed by nature. Remember that your relationship depends on how well you handle it. For your second marriage to work, you need to know what truly happened in the first one. Understanding the reason for its demise will ensure that you won't go through the same obstacles in the next relationship.


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Rocket Science Video Class
Yes, It Really Is Rocket Science!
This is really cool.
Ever see a rocket launch? I mean a real rocket launch – the kind that took Neil Armstrong to the moon?
Next Wed. (Feb 23), there's going to be one, and you can watch the live video feed from it.
Every kid should see this!
Before the launch, Aurora Lipper, from Supercharged Science is doing a live video class online where she'll be teaching about rockets. Your kids will learn how they're built and how they fly.
During the class she'll even take them step-by-step through building their own slingshot rockets.
You can register for free here
At the end of the class, she'll tell you how to access the live video feed for the launch of the rocket (It's a Taurus XL rocket launched from Vandenberg, CA).
Aurora's classes are really second-to-none when it comes to science. I mean her free stuff is way better than lots of paid material out there.
Don't miss this one!
See you there,
P.S. You won't want your kids to miss the tele-class or the live rocket launch. Register now!
Supercharged Science is an affiliate of mine. The class, however, is free, and I earn no fee unless you buy something else.


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Project Description
Modern industrial interpretation, but with a danceable multi-genre seasoning.
#003 / Urbex
These guys may be fresh in the stage, but certainly not new in the scene, if we think about it as a (sub)cultural movement. Algimantas Ivanauskas and Rokas Petreikis is a duo known by many who's into techno and experimental dance music since long time ago. One's a modest and gentle record collector and cassette fan, the other – a strict and straightforward critic whose often bold, but correct observations brightly mark defects of the scene.
Guys reviewed an hour and 18 tracks in their mix of what could be seen as a modern industrial interpretation, but with a danceable multi-genre seasoning: full of techno, electro, EBM and other bangers, but with a slice of ambient and drone atmospherics where fits. A review of old and new, representing of what they loved and liked the most through many years. A pure representation of what these guys sound like both inside and outside.
A generic first question: how did you meet and become friends and subsequently music lovers?
A: We met at school. We've been sitting together since the 5th grade. My first music discoveries were Prodigy and Dream Dance CD compilations. Good stuff.
R: I was living my whole life with music. My father is a very passionate music lover and record collector, so you can say it's in our genes. Since childhood I was listening to classic rock, pop and 70's electronic music. In my teenage years my taste started to change and I switched to British acts (Orbital, Underworld, The Prodigy, etc.) thanks to my aunt's record collection, she was a fan of British electronic music. From that everything moved naturally to other horizons.
You've been active in the scene for years now. How did it all start for both of you personally and evolve into this?
A: For me everything started after a trip on the minimal.lt ravebus to the Up To Date festival in Bialystok. Met a lot of nice people there and started going to parties in Vilnius. Before that, I was digging music at home, isolated from the Lithuanian music scene.
R: I started to party a bit earlier than Algimantas – it was progressive house parties, later moved on to techno and electro. There were noticeable event organisers Step Service here in Kaunas, they organised acid techno parties in abandoned buildings. I have a lot good memories from that time. Later things moved to Vilnius because the Kaunas team disbanded. At that time Algimantas started to join me too.
And how did the local scene evolve during all those years?
A: [poo emoji]
R: To me personally it lost its soul. Today we have a lot of events every weekend, but most of them are copies and don't have a unique identity. A lot of DJs are just following trends and posting Instagram posts instead of developing their unique style, but not everything is lost, because there is a new generation on the horizon.
Is there something you miss from the older days that you don't see present nowadays – people, artists, sounds or mindsets?
A: Strong vision, quality control.
You have quite different temperaments. What are the differences in music?
A: Not much. We both listen to most styles of music and what matters at the end is quality of the track, whether is good or not, and not music genre.
Rokas is known as a person who's not afraid to say some reasoned criticism. How do you see the current techno scene and this on-going boom in popularity as a person who's been into this sound before it was cool?
R: I think techno is past its heyday. We have tons of new releases, but rarely any of them will stand the test of time. You just play it one or two times and delete it to be replaced by something new, so naturally I don't listen much to it nowadays. Techno had its crisis in 00's so it's matter of time when the bubble will explode again, but it applies to all genres that get on a hype train.
Algimantas is well-known as an in-depth melomaniac, especially when speaking about cassette tapes and collecting them. What's so fascinating about the hiss of the tape? Many people see it as an outdated thing or a fetish.
A: And they are absolutely right. Cassettes are impractical and sound like shit compared to other formats. But like with a lot of things in life, you like them not because they are practical. For me personally, I like physical media because you can analyze the artwork and packaging better (if the artist bothered to put any effort into it) to get more context about the music. Cassettes have a bad reputation of sounding bad, and while in a lot of cases that is true, they can sound really nice if recorded properly on good tape. Also, tape hiss and warm sound may go along with some music.
We find it strange both of you didn't start DJing actively before. Why? Have you never intended to do so?
R: I think that my taste in music is now fully matured and I'm comfortable in sharing it with others.
Lithuanian clubs seem to be bringing in the most famous names in music today, every weekend being graced by numerous huge artists and headliners, not to mention the locals throwing parties seemingly every day of the week – yet you can still feel an air of disappointment in the scene. Is it a problem of over-saturation? What should local promoters do to maintain an interest or a sense of uniqueness?
R: It's a deep and complicated topic, but I think it's all about a unique vision. Most organisers take the easy route and book trendy names instead of searching for new young talents and promoting them.
If you were to start a record label or a club night, what would you focus on?
R: If had record label it would keep a strict "less is more" policy. A good source of inspiration is Basic Channel records. They released just 7 records, but what a strong impact it made. Nowadays it's a different time, so you need a lot more to show apart from music to have any chance of showing yourself above all the noise.
Your mix displays a wide array of genres and sounds old and new. Perhaps it is an attempt to disprove the misconception of being solely limited to techno?
R: We were never 100% techno heads, just at an earlier time we were more interested in it, but time passes and tastes change with it. Nowadays we like all kinds of music.
Where is the line between club music and home-listening music for you, if there is one at all?
A: In my opinion, the requirement for club music would be 4×4 beats, since, at least in theory, people come to clubs to dance. While at home you can listen to pretty much anything.
R: It all depends on mood and location.
Hopefully this mix and your performance at the "Urbex" night won't be your first and final outing as a creative duo. Have you got anything planned for the future?
R: I hope we will have other opportunities to perform and then we will think about bigger projects.
By Viktoras Urbaitis and Algirdas Šapoka.
- Sammy Osmo – Verlaten Dierentuin Wassenaar [Strange Life Records, 2008]
- Alpha Wave Movement – Artifacts & Prophecies [Harmonic Resonance Recordings, 1996]
- Isorinne – Reality Is What You Can Get Away With [Field Records, 2015]
- Pump – Falling From Grace [Plague Recordings, 2010]
- Paper Dollhouse – Black Flowers [Night School, Bird, Finders Keepers Records, 2015]
- Forest Swords – Crow [Studio !K7, 2018]
- Pye Corner Audio – Inside The Wave [Black Mill Tapes Volume 3: All Pathways Open, 2012]
- Patrick Cowley – Journey Home [Dark Entries, 2013]
- Led Er Est – PS 18 [Mannequin, 2010]
- Sobranie 8 18 – I Was Sick [Perfect Aesthetics, 2017]
- Chymera – Swim Away (Steve Moore Remix) [Connaisseur, 2012]
- Phase Fatale – The Fall [Ostgut Ton, 2013]
- Umo Detic – Fahrenheit [New Zone, 1989]
- Circuit Breaker – Teacher [Probe Records, 1996]
- Ekman – I Only Hit You 'Cause I Love You [The Trilogy Tapes, 2015]
- A Hand – Paper Scuff [Details Sound ,2014]
- Restive Plaggona – I Can't Say Yes But I Can't Say No [Several Minor Promises, 2018]
- JK Flesh – JK Flesh Merges Prurient 1 [Hydra Head Records, 2013]


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PDF – Indexing on 64bit platforms (Win 7 / Desktop Apps)
PDF iFilter Interface
Adobe does not bundle the iFilter interface in the latest version of Adobe Acrobat Reader 11.x or DC 64bit. You need to manually activate the Adobe iFilter Add-On in order to be able to index and search PDF documents.
Click here to download and install the Adobe iFilter interface: Activate Adobe iFilter Add-On (64bit, Version 11.x or DC)
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The Adobe PDF iFilter enables indexing Adobe PDF documents using Noggle indexing clients. This allows the user to easily search for text within Adobe PDF documents. The key benefits include:
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Stem Cells Finally Deliver, But Not on Their Original Promise
Stem cell therapies remain few and far between, but the versatile tissues are transforming how we understand disease.
To scientists, stem cells represent the potential of the human body to heal itself. The cells are our body's wide-eyed kindergarteners—they have the potential to do pretty much anything, from helping us obtain oxygen, digest food, or pump our blood. That flexibility has given scientists hope that they can coax stem cells to differentiate into and replace those damaged by illness.
Almost immediately after scientists learned how to isolate stem cells from human embryos, the excitement was palpable. In the lab, they had already been coaxed into becoming heart muscle, bone marrow, and kidney cells. Entire companies were founded to translate therapies into clinical trials. Nearly 20 years on, though, only a handful of therapies using stem cells have been approved. Not quite the revolution we had envisioned back in 1998.
Only a handful of therapies using stem cells have been approved.
But stem cells have delivered on another promise, one that is already having a broad impact on medical science. In their investigations into the potential therapeutic functions of stem cells, scientists have discovered another way to help those suffering from neurodegenerative and other incurable diseases. With stem cells, researchers can study how these diseases begin and even test the efficacy of drugs on cells from the very people they're intended to treat.
Getting to this point hasn't been easy. Research into pluripotent stem cells, the most promising type, has faced a number of scientific and ethical hurdles. They were most readily found in developing embryos, but in 1995, Congress passed a bill that eliminated funding on embryonic stem cells. Since adult humans don't have pluripotent stem cells, researchers were stuck.
That changed in 2006, when Japanese scientist Shinya Yamanaka developed a way to create stem cells from a skin biopsy. Yamanaka's process to create induced pluripotent stem cells (iPS cells) won him and his colleague John Gurdon a Nobel Prize in 2012. After years of setbacks, the stem cell revolution was back on.
Biomedical scientists in fields from cancer to heart disease have turned to iPS cells in their research. But the technique has been especially popular among scientists studying neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) for two main reasons: One, since symptoms of these diseases don't develop until rather late in the disease process, scientists haven't had much knowledge about the early stages. IPS cells changed that by allowing scientists to study the very early stages of the disorder. And two, they provide novel ways of testing new drugs and potentially even personalizing treatment options.
"It's creating a sea change," says Jeanne Loring, a stem cell biologist at the Scripps Research Institute in San Diego. "There will be tools available that have never been available before, and it will completely change drug development."
Beyond Animal Models
Long before scientists knew that stem cells existed, they relied on animals to model diseases. Through careful breeding and, later, genetic engineering, researchers have developed rats, mice, fruit flies, roundworms, and other animals that display symptoms of the illness in question. Animal models remain useful, but they're not perfect. While the biology of these animals often mimics humans', they aren't identical, and although some animals might share many of the overt symptoms of human illness, scientists can't be sure that they experience the disease in the same way humans do.
"Mouse models are useful research tools, but they rarely capture the disease process," says Rick Livesey , a biologist at the University of Cambridge in the U.K. Many neurodegenerative diseases, like Alzheimer's, he says, are perfect examples of the shortcomings of animal models. "No other species of animal actually gets Alzheimer's disease, so any animal model is a compromise."
As a result, many drugs that seemed to be effective in animal models showed no benefit in humans. A study published in Alzheimer's Research and Therapy in June 2014 estimated that 99.9% of Alzheimer's clinical trials ended in failure, costing both money and lives. Scientists like Ole Isacson, a neuroscientist at Harvard University who studies Parkinson's disease, were eager for a method that would let them investigate illnesses in a patient's own cells, eliminating the need for expensive and imperfect animal models.
"No other species of animal actually gets Alzheimer's disease, so any animal model is a compromise."
Stem cells appeared to offer that potential, but when Congress banned federal funding in 1995 for research on embryos—and thus the development of new stem cell lines—scientists found their work had ground to a halt. As many researchers in the U.S. fretted over the future of stem cell research, scientists in Japan were developing a technique which would eliminate the need for embryonic stem cells. What's more, it would allow researchers to create stem cells from the individuals who were suffering from the diseases they were studying.
Cells in the body are able to specialize by turning on some sets of genes and switching off others. Every cell has a complete copy of the DNA, it's just packed away in deep storage where the cell can't easily access it. Yamanaka, the Nobel laureate, knew that finding the key to this storage locker and unpacking it could potentially turn any specialized cell back into a pluripotent stem cell. He focused in on a group of 24 genes that were active only in embryonic stem cells. If he could get adult, specialized cells to translate these genes into proteins, then they should revert to stem cells. Yamanaka settled on fibroblast cells as the source of iPS cells since these are easily obtained with a skin biopsy.
Rather than trying to switch these genes back on, a difficult and time-consuming task, Yamanaka instead engineered a retrovirus to carry copies of these 24 genes to mouse fibroblast cells. Since many retroviruses insert their own genetic material into the genomes of the cells they infect, Yamanaka only had to deliver the virus once. All successive generations of cells inherited those 24 genes. Yamanaka first grew the fibroblasts in a dish, then infected them with his engineered retrovirus. Over repeated experiments, Yamanaka was able to narrow the suite of required genes from 24 down to just four.
The process was far from perfect—it took several weeks to create the stem cells, and only around 0.01%–0.1% of the fibroblasts were actually converted to stem cells. But after Yamanaka published his results in Cell in 2006, scientists quickly began perfecting the procedure and developing other techniques. To say they have been successful would be an understatement. "The technology is so good now that I have the undergraduates in my lab doing the reprogramming," Loring says.
Accelerating Disease
When he heard of Yamanaka's discovery, Isacson, the Harvard neuroscientist studying Parkinson's disease, had been using fetal neurons to try to replace diseased and dying neurons. Isacson realized "very quickly" that iPS cells could yield new discoveries about Parkinson's. At the time, scientists were trying to determine exactly when the disease process started. It wasn't easy. A person has to lose around 70% of their dopamine neurons before the first sign of movement disorder appears and Parkinson's can be diagnosed. By that point, it's too late to reverse that damage, a problem that is found in many if not all neurodegenerative diseases. Isacson wanted to know what was causing the neurons to die.
Together with the National Institute of Neurological Disorders and Stroke consortium on iPS cells, Isacson obtained fibroblasts from patients with genetic mutations linked to Parkinson's. Then, he reprogrammed these cells to become the specific type of neurons affected by Parkinson's disease. "To our surprise, in the very strong hereditary forms of disease, we found that cells showed very strong signs of distress in the dish, even though they were newborn cells," Isacson says.
These experiments, published in Science Translational Medicine in 2012, showed that the disease process in Parkinson's started far earlier than scientists expected. The distressed, differentiated neurons Isacson saw under the microscope were still just a few weeks old. People generally didn't start showing symptoms for Parkinson's disease until middle age or beyond.
Isacson and his colleagues then tried to determine what was different between different cells with different mutations. The cells showed the most distress in their mitochondria, the parts of the cell that act as power plants by creating energy from oxygen and glucose. How that distress manifested, though, varied slightly depending on which mutation the patient carried. Neurons derived from an individual with a mutation in the LRRK2 gene consumed lower than expected amounts of oxygen, whereas the neurons derived from those carrying a mutation in PINK1 had much higher oxygen consumption. Neurons with these mutations were also more susceptible to a type of cellular damage known as oxidative stress.
After exposing both groups of cells to a variety of environmental toxins, such as oligomycin and valinomycin, both of which affect mitochondria, Isacson and colleagues attempted to rescue the cells by using several compounds that had been found effective in animal models. Both the LRRK2 and the PINK1 cells responded well to the antioxidant coenzyme Q10, but had very different responses to the immunosuppressant drug rapamycin. Whereas LRRK2 showed beneficial responses to rapamycin, the PINK1 cells did not.
To Isacson, the different responses were profoundly important. "Most drugs don't become blockbusters because they don't work for everyone. Trials start too late, and they don't know the genetic background of the patient," Isacson says. He believes that iPS cells will one day help researchers match specific treatments with specific genotypes. There may not be a single blockbuster that can treat Parkinson's, but there may be several drugs that make meaningful differences in patients' lives.
Cancer biologists have already begun culturing tumor cells and testing anti-cancer drugs before giving these medications to patients, and biologists studying neurodegenerative disease hope that iPS cells will one day allow them to do something similar for their patients. Scientists studying ALS have recently taken a step in that direction, using iPS cells to create motor neurons from fibroblasts of people carrying a mutation in the C9orf72 gene, the most common genetic cause of ALS. In a recent paper in Neuron , the scientists identified a small molecule which blocked the formation of toxic proteins caused by this mutation in cultured motor neurons.
Adding More Dimensions
It's one thing to identify early disease in iPS cells, but these cells are generally obtained from people who have been diagnosed. At that point, it's too late, in a way; drugs may be much less likely to work in later stages of the disease. To make many potential drugs more effective, the disease has to be diagnosed much, much earlier. Recent work by Harvard University stem cell biologist Rudolph Tanzi and colleagues may have taken a step in that direction, also using iPS cells.
Doo Yeon Kim, Tanzi's co-author, had grown frustrated with iPS cell models of neurodegenerative disease. The cell cultures were liquid, and the cells could only grow in a thin, two-dimensional layer. The brain, however, was more gel-like, and existed in three dimensions. So Kim created a 3D gel matrix on which the researchers grew human neural stem cells that carried extra copies of two genes—one which codes for amyloid precursor protein and another for presenilin 1, both of which were previously discovered in Tanzi's lab—which are linked to familial forms of Alzheimer's disease.
After six weeks, the cells contained high levels of the harmful beta-amyloid protein as well as large numbers of toxic neurofibrillary tangles that damage and kill neurons. Both of these proteins had been found at high levels in the neurons of individuals who had died from Alzheimer's disease, but researchers didn't know for certain which protein built up first and which was more central to the disease process. Further experiments revealed that drugs preventing the formation of amyloid proteins also prevented the formation of neurofibrillary tangles, indicating that amyloid proteins likely formed first during Alzheimer's disease.
"When you stop amyloid, you stop cell death," Tanzi says. Amyloid begins to build up long before people show signs of altered cognition, and Tanzi believes that drugs which stop amyloid or prevent the buildup of neurofibrillary tangles could prevent Alzheimer's before it starts.
The results were hailed in the media as a "major breakthrough," although Larry Goldstein, a neuroscientist at the University of California, San Diego, takes a more nuanced perspective. "It's a nice paper and an important step forward, but things got overblown. I don't know that I would use the word 'breakthrough' because these, like all results, often have a very long history to them," Goldstein says.
The scientists who spoke with NOVA Next about iPS cells noted that the field is moving forward at a remarkable clip, but they all talked at length about the issues that still remain. One of the largest revolves around differences between the age of the iPS cells and the age of the humans who develop these neurodegenerative diseases. Although scientists are working with neurons that are technically "mature," they are nonetheless only weeks or months old—far from the several decades that the sufferers of neurodegenerative diseases have. Since aging remains the strongest risk factor for developing these diseases, neuroscientists worry that some disease pathology might be missed in such young cells. "Is it possible to study a disease that takes 70 years to develop in a person using cells that have grown for just a few months in a dish?" Livesey asks.
So far, the answer has been a tentative yes. Some scientists have begun to devise different strategies to accelerate the aging process in the lab so researchers don't have to wait several decades before they develop their answers. Lorenz Studer, director of the Center for Stem Cell Biology at the Sloan-Kettering Institute, uses the protein that causes progeria, a disorder of extreme premature aging, to successfully age neurons derived from iPS cells from Parkinson's disease patients.
"Is it possible to study a disease that takes 70 years to develop in a person using cells that have grown for just a few months in a dish?"
Robert Lanza, a stem cell biologist at Advanced Cell Technology, takes another approach, aging cells by taking small amounts of mature neurons and growing them up in a new dish. "Each time you do this, you are forcing the cells to divide," Lanza says. "And cells can only divide so many times before they reach senescence and die." This process, Lanza believes, will mimic aging. He has also been experimenting with stressing the cells to promote premature aging.
All of these techniques, Livesey believes, will allow scientists to study which aspects of the aging process—such as number of cell divisions and different types of environmental stressors—affect neurodegenerative diseases and how they do so. Adding to the complexity of the experimental system will improve the results that come out at the end. "You can only capture as much biology in iPS cells as you plug into it in the beginning," Livesey says.
But as Isacson and Loring's work, has shown, even very young cells can show hallmarks of neurodegenerative diseases. "If a disease has a genetic cause, if there's an actual change in DNA, you should be able to find something in those iPS cells that is different," Loring says.
For these experiments and others, scientists have been relying on iPS cells derived from individuals with hereditary or familial forms of neurodegenerative disease. These individuals, however, only represent about 5–15% of individuals with neurodegenerative disease; the vast majority of neurodegenerative diseases is sporadic and has no known genetic cause. Scientists believe that environmental factors may play a much larger role in the onset of these forms of neurodegenerative disease.
That heterogeneity means it's not yet clear whether the iPS cells from individuals with hereditary forms of disease are a good model for what happens in sporadic disease. Although the resulting symptoms may be the same, different forms of disease may use the same biological pathways to end up in the same place. Isacson is in the process of identifying the range of genes and proteins that are altered in iPS cells that carry Parkinson's disease mutations. He intends to determine whether any of these pathways are also disturbed in sporadically occurring Parkinson's disease to pinpoint any similarities in both forms of disease.
Livesey's lab just received a large grant to study people with an early onset, sporadic form of Alzheimer's. "Although sporadic Alzheimer's disease isn't caused by a mutation in a single gene, the condition is still strongly heritable. The environment, obviously, has an important role, but so does genetics," Livesey says.
Because the disease starts earlier in these individuals, researchers believe that it has a larger genetic link than other forms of sporadic Alzheimer's disease, which will make it easier to identify any genetic or biological abnormalities. Livesey hopes that bridging sporadic and hereditary forms of Alzheimer's disease will allow researchers to reach stronger conclusions using iPS cells.
Though it will be years before any new drugs come out of Livesey's stem cell studies—or any other stem cell study for that matter—the technology has nonetheless allowed scientists to refine their understanding of these and other diseases. And, scientists believe, this is just the start. "There are an endless series of discoveries that can be made in the next few decades," Isacson says.
Image credit: Ole Isacson, McLean Hospital and Harvard Medical School/NINDS, UC Irvine/Flickr (CC BY-NC-ND)


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I'm Sorry by Brenda Lee
Mike Check: Weeelll fellers! Ole Mike thought that I might play "I'm Sorry" by Brenda Lee to smooth things over with the fellers over at wrestlecrapadio.com. Hopefully this works well in their market?
*phone rings*
Mike Check: KMCR Radio?
Raging_Demons: Nope. Not gonna work Mike!
Posted on March 2, 2017, in music and tagged wrestlecrapradio.com. Bookmark the permalink. Leave a comment.


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Electronic Health Records (EHRs) are a critical but expensive part of any hospital's technology infrastructure. Here's a look at the state of the inpatient EHR market today at non-federal, acute care hospitals, based upon Definitive Healthcare data – showing a distinct difference between non-critical access and critical access hospitals.
Data for non-critical access, non-federal acute care hospitals show a market dominated by major vendors. Nearly three fourths of the hospitals examined use an Epic, Cerner, or Meditech system. Allscripts comes in at a distant fourth, followed by CPSI. Epic and Cerner systems are more common at larger, IDN-affiliated hospitals with relatively high bed counts and patient revenue. Among lesser-deployed systems, CPSI, which focuses its products on rural, community, and critical-access hospitals, was installed at hospitals with the lowest median patient revenue, median discharges, and lowest rate of affiliation with IDNs. The vast majority of hospitals with proprietary EHR systems are part of national for-profit corporations. Their large geographic footprint and traditionally higher margins make it more practical for them to build and maintain an in-house system.
Among critical-access hospitals unassociated with IDNs, CPSI and Epic comprise over half the market. Allscripts barely makes the top five, and Athenahealth has fewer than 100 implementations. Smaller vendors with less of a national presence also make up a significant portion of critical-access hospital EHR deployments compared to standard acute care facilities. The picture changes for critical access hospitals owned by IDNs, which is unsurprising given that IDNs would choose a single vendor for all of their facilities and companies like Epic and Cerner are already widely deployed in other hospitals and ambulatory settings.
Deployments at Acute Care Hospitals by Vendor Market Share
Download the full list using the form on the right!
- Name
- 48 Hannah Gelbs
- 49 Eric Evans
- 50 Kerry Eaton, MS
- Title
- Prev. Employer
- 48 West Houston Medical Center
- 49 East Houston Regional Medical Center
- 50 Gulf Coast Health Care System
- New Employer
- 48 Cypress Fairbanks Medical Center
- 49 Tomball Regional Medical Center
- 50 Health Quest
- Date of Move
- 48 Dec 11, 2017
- 49 Dec 11, 2017
- 50 Dec 8, 2017


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Simply no Child Put aside and
No Kid Left Behind as well as its Effects on Urban School Districts Essay
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Dutch Republic In 1650 the Nederlander Republic had become a commercial, monetary, and nautico powerhouse, which led to other European countries recognizing that as the banking and trading…...Read
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text: Having trouble getting a new program or initiative off the ground? Not sure how to get employee buy in? Is your company going through changes and you find yourself facing resistance? Have a shelf full of good programs that you'd like to turn into great ones? The Energized Approach for Achieving Great Programs will help you "power-up" your next program. Organizations that focus on the 10 Essential Energy Sources create environments that are really ready for action! Using real-life examples, stunning visuals and an easy humorous style, Michael will introduce you to "The Energized Approach" that will maximize the return on investment for your company's programs.


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I just read some formulas for happiness by the philosopher Epictetus (AD 55-135). We're to know what we can control, i.e., our likes and dislikes, and our opinions; everything else is under another's control apparently. We're to understand that we don't select the role we play in life; it's chosen for us, but we're to play it the best we can. The things that we accumulate, we're to relinquish freely when we return to the ship that dropped us at the port of life. (My words, not Epictetus', which must be obvious). We're not to covet, but to take part in the good things served to us, but not to reach before they come or after they've passed us by.
I'm probably not doing justice to Epictetus. But I do like thinking about my definition of happiness as well as others'.
I think Erik Erikson defined the formula for happiness that most matches mine, or more likely, I've adopted his: a loving relationship, meaningful work, and good health. Two of these three result in happiness.
I'd drink to that, a cup of coffee, which is one happy reward for me six days out of seven, and definitely a happy-maker for me. I'd throw in more specifics for happy-making: some time in the ocean or Greenwood Lake, time with kids and irresistible granddaughter, time with books and music and NPR, time with my sweet dog, time with treasured friends, time with my two writing groups.
Someone, maybe Samuel Johnson, said happiness came from doing new things constantly, and I'm convinced that having new adventures slows the speed of life. But old, cozy habits, like City Theater, Drew/Heinz lectures, Chatham work-outs, fills the bill, too
So wonderful relationships, useful, enjoyable work, and the luck of good health plus new and old adventures captures my view of happiness.
What is yours?


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Hello world.
My name is Ross Clurman. I'm a Texan, but was born and raised in the Show Me State.
I believe experiences > things. My North Star metric: time. More specifically, time spent doing what I love:
- reading/learning
- biking/exercising outdoors
- visiting friends/family
- traveling/spending time with my wife + pets
I also enjoy volunteering, writing, daydreaming, and brainstorming—but, I won't bore you with any more details about me.
Cold Calling Is Not Dead, But…
Let's face it, 99% of inbound sales calls are bullshit. Some SDR in a call center has a list of names, with you on it because of your: title, industry,…Read More »
Mother's Day 2018
Both my mother and step-mother tell me—as they've told me for years: "The best gift you can give me on Mother's Day is a phone call." So, at the very…Read More »
Work-Life Balance: 10 Ways To Tip The Scale
Thankfully, I love what I do—marketing—so working hard, long hours doesn't necessarily disrupt my work-life balance. Even working 50-60 hours/week, I'm still able to spend plenty of time with friends…Read More »


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about what people eat.
My Dad used to eat "goody" for a snack.
White bread soaked in a bowl of milk
and covered with sugar.
I always thought "goody" was a pet name
he gave this particular snack.
It wasn't until I was reading a book with the subject matter
being Ireland
that I learned that this was an actual dish the Irish ate.
No wonder "my people" drink so much.
When I came on this boat
I noticed the cereal selection was healthy,
cereals with almonds and stuff like that.
Not one Frosted Flake box to be found.
It turns out, the selection I was looking at
was the left overs from the last crew.
That all changed when we got a chance to go shopping.
I couldn't wait to find out
who wanted to be crunch-a tized.
It turns out Carl is the man.
Have you ever seen the show "The Deadliest Catch?"
Well Carl is a real life Deadliest Catcher.
His career on a tug boat is in it's infancy
as he spent the better part of his adult life
braving the elements in the waters off Alaska
in search of king crab.
He'd still be there if the Exxon Valdez spill
didn't ruin his livelihood as well as hundreds of other fisherman.
When I asked him what he thought of the show
The Deadliest Catch, he disgustedly said,
"Oh those rookies..."
It's a fact that commercial fisherman
is the most dangerous industry there is anywhere.
Carl tells me stories that keep me awake at night.
But when I see Carl chowing down on a big sugary bowl
of Captain Crunch before he goes to bed,
I usually say something like
"Oh, is Mr. Deadliest Catch eating some Captain Crunch
before he goes nighty night?"
Then I run to my room.......fast.


text:
Bitchain, a Catalonian bitcoin service, will launch their first ATM in the centre of Athens on 11 July. The company seeks to collaborate with Greek bitcoiners to promote digital currency in the midst of the crisis.
A Barcelona-based company, Bitchain.es specialises in bitcoin ATMs and until now has been targeting their services at Spanish-speaking customers. According to the map on the website, Bitchain has already installed 9 bitcoin ATMs in cities across Spain. However, the current crisis and the dramatic development of the bitcoin market in Greece prompted the start-up to set up a bitcoin ATM network there.
The first Bitchain ATM will be installed at the Centre of Innovation, The Cube, at 11:00 on Saturday, 11 July. The ATM will buy and sell bitcoins in exchange for euros. It will be possible to withdraw up to €1,000 per transaction despite the government control of the currency in the country. Bitchain also tweeted that their bitcoin ATM in Athens would have 0% service fee.
The first bitcoin ATM in Athens was installed in Orizontes bookshop by EasyBitLLC. However, this ATM only allows users to buy digital currency and does not have an option to buy bitcoins for euros which may be more desirable in the current situation in Greece. Bitchain machine will be the first two-way bitcoin ATM in Athens.
Previously, CoinFox reported about the first bitcoin ATM that was installed in the Catalonian University in collaboration with BTCPoint. Michael Oliver, a professor at the Department of Information Technology and Communications (DTIC) stated that the goal was to encourage a discussion on the impact of Internet technologies on people's lives by educating the public on cryptocurrency use.
Aliona Chapel


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|rpm based
|deb based
|service httpd start
|invoke-rc.d apache2 start
|rpm -q
|dpkg-query -W
|rpm -qf
|dpkg -S
|rpm -ql
|dpkg -L
|rpm -qi
|dpkg -p
|yum info
|apt-cache show
rpm -qi shows Vendor so you can see who built the package and usually what repository it came from. To see similar info with Debian use 'apt-cache policy package' This will show an http:// url so you can tell what source it came from.
I passed a certificate of expertise exam on clustering and storage today. I didn't take the class, rather studied with associates and by myself on my own time. This is my first RHCA level exam that I have taken.
Here is the course outline if you're interested in what the class/exam covers:
I got this error after installing:
$ ioquake3
./ioquake3.i386: error while loading shared libraries: libopenal.so.0: cannot open shared object file: No such file or directory
Make sure you have libopenal1 package installed and then make a symlink from /usr/lib/libopenal.so.0 to the actual library file.
# ln -s /usr/lib/libopenal.so.1.4.272 /usr/lib/libopenal.so.0
Run ldconfig just to be safe.
# ldconfig
ioquake3 now works.
Well I didn't believe it but it happened. It snowed enough to stick and is still snowing in Raleigh, North Carolina. I woke up at 5:30 am dreaming of snow and decided to take Maggie for a walk and take some pictures along the way. Road conditions are pretty bad and sometimes it's windy. Reminds me more of my college time in Boone, NC than the piedmont.
Pictures of Snow in Raleigh North Carolina 2009-01-20
I am most familiar with RHEL/Fedora and I commonly use autofs with direct maps to mount NFS servers. Direct maps are not well supported in autofs4 but work great with autofs5. In fact on RHEL 4 and Debian Lenny/testing which both ship with autofs4 you have to manually enable direct maps in either /etc/sysconfig/autofs or /etc/default/autofs configuration files.
I'm used to using autofs5 in RHEL 5 and newer Fedora versions but as it turns out autofs5 is not included in Debian Lenny/testing which I'm trying out at home. One of the issues I ran into with autofs4 is that you can't mount the key directly under the root filesystem. You have to make the key under some other directory first. This behavior is described really well in this bug report against autofs4 on Fedora Core 3 https://bugzilla.redhat.com/show_bug.cgi?id=145533
Anyway if you want to get around that issue on Debian Lenny/testing it's easy to just install autofs5 from the unstable branch this way:
# aptitude install autofs5/unstable
That command/syntax is explained on this page, section 6.2.6:
You don't have to do this anymore. Debian Lenny stable still seems to include autofs4 by default though. On Debian Lenny which is now stable just do 'aptitude install autofs5'
Sometimes when people are explaining things to me or when they are teaching me I get a slight tingling sensation in my entire head. I'd definitely compare it to a mild buzz from a drug of some kind. It feels so good yet so mild and unobtrusive that if you could easily and regularly reproduce it from taking a drug without any negative side effects it would surely be a very popular drug.
The first time I noticed it I was in kindergarten. It was a Montesorri preschool in Durham, NC where I was born. A female classmate of mine was demonstrating how to assemble or use some sort of toy. I believe it was puzzle like. She was speaking about it while she did it and explaining very well the steps you take, in what order and how to complete each step. I remember getting the tingling feeling and noticing it and suddenly becoming less interested in what she was showing me in the foreground and more interested in the buzz that started in the back of my head and slowly consumed my entire head.
Today I most often notice the buzz at work. I work in tech support and often have to listen to customers explain their computer network/servers/internet services and environment in detail. Sometimes when they explain it the right way I will get the buzz. I love it but it never lasts more than a minute or so. The fact that it never lasts more than a minute I think makes it more enjoyable too. Knowing that I only will get to enjoy it for a minute or so makes me concentrate on it more and makes it more special.
Sometimes I try to explain it to friends but no one I've ever explained it to has ever been familiar with anything like it. I think it's really odd that it is a specific feeling that I only get during really specific interactions with other people. I wonder if I've learned to expect it or create the feeling around those specific interactions because I first felt it under that type of interaction. Who knows?
I made an account on vimeo.com for uploading videos. The quality is very good compared to youtube so I will use this to upload videos from Europe and anything else in the future I think.
Here is my first video:
I also added a bunch of biking videos from Paris day 2 on my own gallery:
I uploaded all mine and Matt's Europe pictures. There are over 1000. There is definitely some redundancy.. so I will have to weed that out. Within each album mine come first then Matts. They should be chronological.
London > Paris > Amsterdam > Berlin > Copenhagen > Stockholm
We left Raleigh on time around 6pm after enjoying a beer at the Admirals club at the airport thanks to Matthew's American Express Platinum card. The flight was unextraordinary. Matt slept during much of it because he has the gift from God to sleep anywhere. As for me, sleeping on the plane didn't happen much. Mostly I just counted the hours and slowly realized that I was going to arrive in a foreign country where the sun would just be coming up.. and to me it would feel like 1 or 2 am.
We landed around 6am after waiting in a holding pattern around Heathrow because they didn't want us to wake the Londoners.
We got our bags and followed the signs to the tube.
We got on Picadilly line terminating at Cockfosters. On the train we rode past our intended destination almost to the end of the line. On the Train Matt is telling me all the different monuments and interesting places we are going to see. All I can think about is, "but when do we sleep before all this?"
We went back on the right train and finally got Hampstead where we called Leo and met him around 10am. Leo is a former Red Hat employee out of the Farnborough, UK office that Matt knows through work. We arranged to stay with him this first day of our journey.
We showered and went out walking around London South of river Thames.
Some major landmarks we saw were Big Ben and The Parliament, London Eye, former city Hall, London Bridge, London Tower and Tower Bridge. We had fish and Chips at Hornimans pub. Then we went to Buckingham Palace and St. James park where we saw a friendly but fat squirrel (see youtube videos <link>). We continued walking around London and ended up at Trafalgar Square Shopping district. In Trafalgar Square there was a concert with Indian singers and lots of Indian people and Indian food and the like. We continued on into more very very busy streets/intersections.
On Friday October 10th around 6pm myself and Matthew went on a two week Europe backpacking trip mostly planned by Matthew. Matthew was the experienced travel buff and I was along for the ride per se. At 6pm we left from Raleigh Durham airport for London Heathrow. We arrived around Saturday 6am local time in London after about 7.5 hours in the jet. We stayed the night and left in the morning on the chunnel for Paris. Wednesday the 15th we left Paris by train to Amsterdam. This will be the last train. On Friday morning we left by plane for Berlin. Monday morning we left for Copenhagen. We stay in Copenhagen until Thursday the 23rd when we fly to Stockholm, Sweeden. Saturday night I fly back to London while Matt stays in Stockholm with a friend. Sunday morning I fly back to Raleigh. Matt stays with the friend for the remainder of the week and works in Farnborough, UK at the Red Hat office located there.


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Are you facing assignment preparation jitters and often asking yourself, "who will do my assignment?" If so, no need to stress any further as total assignment helps specializes in helping you solve these tedious assignments.
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The syllabus in schools and colleges is increasing day by day. Every new day, fresh information is being added to the textbooks. As a result, the volume of textbooks is also increasing. But unfortunately the timings and time period for graduation are the same. Teachers are asked to cover the broad syllabus within the given time. They are hardly able to cover a single topic, in a lecture of the entire day. Therefore, to give you in-depth knowledge and education they ask you to do the assignment. An assignment is given to check the capability of the student in a particular subjector topic that is related to his academic course. It also helps highlight their self-study skills which is essential towards further learning and growth.
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Give yourself enough time to plan and research before you actually start writing an assignment. This will help you avoid any kind of rush to meet your deadline.
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Step 1: Planning - planning will keep your focus and right on track. You need to understand the worth of your assignment and then decide how much time should be divided accordingly. Check the marking rubric to identify what your mentor will be looking for when they check your work. This will ensure that you are focusing on the right context. Make a to-do list of all the things you need to cover, in order to complete your assignment and allocate a deadline to every task in your list.
Step 2: Analyzing the question - you need to understand the question before you answer it. Read it carefully with patience and try to understand what is required and expected. When analyzing the question, try to look for instructional words which indicate specific needs.
Step 3: Drafting an outline–this will give you a structure to follow when writing your assignment. Check the marking rubric and question which will also highlight the expected structuring and what must be included in the topic to deliver maximum relevance.
Step 4: Finding information- Prior to writing, you must research the given topic and seek suitable and relevant information. Other than finding information in your course materials, you can also locate them from the open polytechnic library, by talking to experts, at the local public library, etc. After you have found reliable information, don't forget to evaluate it to make sure that it is apt for your assignment.
Step 5: Writing–When you are done finding the information you need,it's time for you to bring it all together and start writing.
Step 6: Editing and proofreading- Once you have successfullywritten the assignment, improve it by editing and proofreading. Don't forget to take a break in between as it will help you check your assignment with a fresh mind and eye.
Structure of an assignment
Writing an assignment involves following general principles, when writing, Introduction (10% of the assignment), Body Paragraphs (80% of the assignment), and Conclusions(10% of the assignment). It is advised you first check the type of assignment you are asked to create and consider the most suitable structure for that Assignment before writing.
Types of assignments we cover
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Sign Up Everyone has played Halloween games at some point in his or her life. The most common and popular games have really been overused; games like bobbing for apples and telling ghost stories have been popular for over a century. Adding some creative and original games can really add some punch ...Read More »
Halloween Door Decorating Ideas Office
Halloween Door Decorating Ideas For Teachers
Halloween Decor Ideas
Kid-Friendly Halloween Party Games & Snack Ideas
Sign Up Halloween is a time for weird and spooky fun and Halloween is the first of the major holiday season. It's a great time for families to get together to create some fun and make memories. Here are some great kid-friendly Halloween games and snack ideas for any budget and age. ...Read More »
Top 5 Halloween Party Theme Ideas for This Year
Sign Up Ah, Halloween, time for kids to go out begging for candy. It is also time to dress up and be something/someone else for one night of the year and not be considered a freak. Along with trick or treaters come the fun night of parties and get togethers. ...Read More »
Healthy Halloween Party Snacks for the Kids
Sign Up Halloween is coming up. That means plenty of candy will be given to kids. It also means are have events in and out of schools for the kids. However, concerns about childhood obesity and other health issues could make some families avoid anything with sugar in it. Families ...Read More »
Halloween Party Tips
Halloween party is a lot of fun but also takes a bit of creativity. A Halloween party can set the mood in your home in many ways. It is more than a matter of costumes, but also food, decoration and music are important items for a spectacular Halloween party. INVITATIONS ...Read More »
Throw a Great Halloween Party for Dogs
Sign Up How to Celebrate the Best Holiday with Your Best Friend and His Friends Hosting a Halloween party for dogs can be great fun if it is done right, but what a disaster if it is not. Advance planning can go a long ways toward making sure your party is a ...Read More »
Children's Halloween Party Ideas
Sign Up Halloween is a fun holiday for children. It is also a great time to have a Halloween party. Try keeping things simple, by inviting a small number of kids. Five kids will make a great party and keep things less hectic. When planning a children's Halloween party, the ...Read More »


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Veratox® for Tylosin is a competitive enzyme immunoassay for the quantitative analysis of tylosin in muscle.
Veratox for Tylosin enables international and government regulatory agencies, food manufacturers and processors, as well as quality assurance organisations, to detect tylosin in muscle and to satisfy customer concerns about food safety.
Features and Benefits
- Accurate and easy-to-use
- Cost effective microwell format
- High specificity
Product Specifications
- Assay Range: 10–250 ppb
- Controls provided: 0, 1, 2.5, 5, 10 and 25 ng/mL Tylosin
- Testing time: 75 minutes
- Tests per kit: Up to 36 run in duplicate
Order Details
|Product #
|Product Description
|Veratox for Tylosin
Reference Materials
For additional information or questions about product SDS documents, please contact Neogen at firstname.lastname@example.com.


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Surrounded by first-class shops and restaurants, Long Realty's River/Campbell office boasts a premier location on the Southwest corner of River Road and Campbell Avenue. "Our office really serves the heart of Tucson and is the gateway to the Catalina Foothills to the North and historic central and university neighborhoods to the south," states Linda Moore, branch manager of the River/Campbell office location. Moore further states, "Our premier location has a stronger presence in more areas of town than any other realty office."
This group of successful real estate professionals can best be described as fun-loving with a wealth of training. In addition to quarterly celebrations that include chili cook-offs and patio concerts, these positive and professional individuals have one goal: to provide the best customer service to their clients.


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It's been a long time coming, and after a 21-year hiatus in the United States, the Toyota Supra finally back.
However, this has been met with mixed reviews from the automotive world. Yay! It's back. Boo! It looks like a BMW Z4. And, I must admit, I have swung between these two emotions myself.
But after a day behind the wheel and some time spent with execs, I have a better understanding of the Toyota/BMW partnership and what it means for the Supra.
Here are five things to know:
The Supra is a coupe
I know I'm stating the obvious here, but the second part of this statement is: The 2019 BMW Z4 is a convertible. And never the twain shall meet.
That was part of the Toyota/BMW agreement so that the waters don't get muddy. The two automakers collaborate, and BMW builds the convertible, while Toyota builds the hardtop coupe. Yes, BMW has previously had a Z coupe in its lineup, but it won't anymore starting with the 2019 model year.
In fact, when Tatsuya Tada, Supra's chief engineer, talked about the partnership, he compared the Z4/Supra relationship to the relationship between the Porsche Cayman and Boxter. Complementary not competitive.
The Z4 and Supra interiors are more different than you think
If you look at the Supra's interior without looking at the Z4's interior, you'll be tempted to think it's a carbon copy. From the iDrive-like interface to the multimedia dial, it looks a lot like a BMW interior. A lot.
And yes, the telematics are distinctly BMW – right down to the wireless Apple CarPlay that we'll discuss below.
But. When comparing the 2019 Z4 and Supra next to each other, they don't look alike.
Tada acknowledged the similarities but said the interior parts are 90 percent different.
Wireless Apple CarPlay may come with a subscription fee
Toyota has just started putting CarPlay in its vehicles. Now the partnership with BMW has allowed it to become the second automaker that offers this feature wirelessly.
It's a neat trick that eliminates the need for pesky wires, especially since Supra also has an available wireless charging system. No muss, no fuss.
But if you are familiar with BMW at all, you know that everything is an option on its vehicles. And BMW's CarPlay system is the only one out there that currently charges an annual subscription fee. Since Toyota is borrowing this tech from BMW, that begs the question: Will Toyota also charge an annual subscription fee?
Toyota execs didn't say yes. But they didn't say no, either. It's "under discussion" was the official line. CarPlay in Supra will come with a 4-year trial, which gives Toyota some time to make up its mind on the whole fee-add thing.
The engine is BMW's inline 6-cylinder
One of the biggest reasons – if not the biggest reason – Toyota sought out a partnership with BMW is because of its inline 6-cylinder engine. Z4 had one. Supra needed one.
Even though it's the same engine, it's been tuned differently. The Supra's engine will deliver 335 horsepower and 365 pound-feet of torque. This is about 50 horsepower less than the Z4, and it translates into a 0-to-60-mph time that is 0.2 seconds slower (4.1 in the Supra vs. 3.9 in the Z4).
Less horsepower doesn't mean less fun, however, and Tada said they didn't add more horsepower because it wouldn't make track lap times any faster.
There is no manual transmission
Enthusiasts everywhere are sniffling a bit over this omission. Yes, the 8-speed automatic is swift and smooth, and yes, the automatic will work to shift gears faster than a human and thus make the Supra go faster quicker.
But still. In this driver's humble opinion, there is nothing that provides greater satisfaction or connection to the car than a well-made manual.
At present, there are no plans to put a manual transmission in the Supra in the U.S., and it's worth noting that the Z4 is automatic-only as well.
The Bottom Line:
There's no denying the relationship and, in some cases, design similarities between the Z4 and the Supra. But both vehicles were developed separately and are intended to be more complementary than competitive.
Plus, as several execs pointed out during the press preview, without this partnership, Supra would likely still be two to three years away from launch.
Personally, I'm glad it's here now.


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Assembly Hall Café & Bar is where we take the opportunity to brighten your day or wind you down for the evening ahead. We offer a deliciously simple menu with our take on some classic dishes. We pair our healthful fair with an extensive coffee menu, freshly pressed juices, the perfect Washington wine selection and craft brews.
We offer free WiFi and boardgames, our space is the perfect place to finish up work without getting interrupted, take a reprieve from the day, or stop in with friends before heading home for the day. Oh, and don't forget about Trivia nights every Thursday!
For more information, please contact Molly Melkonian, General Manager, at email@example.com or call (206) 812-8413.
English muffin, fried egg, pickled pepper mayo, Colby jack
Pecan flax toast, smashed avocado, pickled beets, feta, herbs
Scrambled eggs, bacon, hashbrowns, habanero jack, tapatio crema, salsa, flour tortilla
Ellenos yogurt, espresso honey
Peanut butter, banana, almond milk, honey, cinnamon
Delicata squash, pickled beets, red onion, barrel aged feta, mixed greens, tahini vinaigrette
Three crispy fried chicken tenders, sweet potato fries, honey mustard dip
Falafel, arugula, pickled veggies, tomatoes, cucumber-dill yogurt dressing, warm pita
Roasted delicata squash, cucumbers, colby jack, feta, coriander chutney
1/4 pound beef patty, Colby jack, grilled onions, pickles, pickled pepper mayo, iceberg, toasted bun
Herbed turkey breast, tuscan kale, delicate squash, provolone, cranberry mayo, stuffing foccacia
Mama lil's pico de gallo, mozzarella, crema
Beef, carrots, corn, habanero jack, corn tortilla
Dole whip drowned in rose, aperol float
Rum shaken hard w/ lime and orgeat, dole whip float
Dole whip swirl, pineapple, chocolate covered mango, toasted coconut, whip cream, macadamia nuts
Dole whip, dark chocolate fudge, cayenne crispies
House strawberry-vanilla soda poured over dole whip
French wine, blood orange, bitter, orgeat
French wine, elderflower, juniper, lemon
French wine, bosc pear, lemon, cardamom
Bourbon, soda, mint
Vodka, bloody mix, spices
Lime, vodka, soda
Tequila spiked sparkling
assembly hall roast | yukon espresso
until 3pm
add ginger or cayenne & lemon $0.50
Enjoy the open mezzanine level of Via6 where you and up to 50 guests can experience delicious appetizers or a family-style dinner from any of our three properties (Assembly Hall, Tanaka San or Home Remedy). In between platters of dumplings or hot-off-the-grill sliders, test your skills with five interactive games (billiards, standing shuffleboard, vintage video games and assorted board games also located on the mezzanine. Please contact firstname.lastname@example.com for more information and booking.
We are super excited to introduce Thursday night TRIVIA with Geeks Who Drink! Geeks Who Drink is a homegrown Pub Trivia Quiz modeled after those in Ireland and the UK. Our quizzes cover everything from celebrities in trouble to wordplay to bad television. Each quiz has two audio rounds: a "Name that Tune" style round, and another round comprised of soundbites from movies and TV. Play in teams of up to six or by yourself if you're some kind of savant. If you want to play but don't have a team, come anyway. We can usually get single players recruited onto an existing team. Winning teams gets street cred, bar cash and other prizes depending on the venue. Bonus Questions for free pints are sprinkled throughout the quiz. You don't have to be a trivia God to enjoy the quiz. Since you're playing on a team, the collective knowledge base makes for more fun, less pressure.


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ViewPoints Psychotherapy is a local psychotherapy and counseling center that proudly serves individuals of all ages in the Colorado Springs community. Our staff offers a variety of psychotherapy services, ranging from exposure and response prevention to trauma therapy, for civilian clients, government agencies, former military members and more.
We genuinely care about and value each and every one of our clients, and our mission is to provide you with effective alternative treatments by cultivating an environment of growth and development. Our entire staff consists of highly trained, experienced and qualified individuals who can successfully handle your case — no matter your situation.
We are firm believers and practitioners of ethical exclusivity, which is sadly something not all counseling practices can say. Too often, counselors choose quantity over quality in an effort to raise a buck. When they do this, they neglect to provide their clients with the highest quality of treatment and care.
We're proud to say we do not do this at our psychotherapy center. We recognize that overscheduling clients in order to profit is unethical, which is why we distinguish ourselves distantly from such facilities and practices.
ViewPoints Psychotherapy provides services that address the many struggles you're bearing, and we teach you wisdom, courage and empowerment. This strategy enables you to obtain a life that doesn't just get you by, but allows you to live a life you are happy to live — a life you look forward waking up to each day.
We strive to meet with everyone who requests our services, but we believe it takes sincere integrity to know when excellent treatment and superior services get blurred with becoming just another run-of-the-mill treatment facility that values money over results. When it comes down to it, our staff at ViewPoints Psychotherapy values your satisfaction over your money.
Simply put, we periodically undergo brief periods where we do not accept any new clients. This is so we can provide our current clients with nothing less than what has been clinically and empirically proven to effectively help them during their treatment processes.
But don't fret — if we don't work with you directly, we can still connect you with a local therapist who is a good match for you, and who also exercises the same philosophy and principles as us.
We think it's important to offer weekend and evening appointments for our clients, so we ensure to have members on staff who can cater to those with busy work schedules and to those who can't always make it into our office during the week.
Our goal is to provide you with well-rounded psychotherapy and counseling services to not just part of you, but the whole you. That's why we've formed partnerships with medical professionals, substance abuse specialists, dietitians and personal trainers.
We offer evidence-based treatment services that have been clinically proven as effective for treating our clients' needs, and each of our staff members will work with you to find a solution that works best for your situation.
More than half of our staff is a veteran themselves or has someone in their family who is in the military, so we appreciate, understand and can relate to those who have served our country. We are proud to offer our psychotherapy services to the military population in need.
Our goal is to help guide you to a more fulfilling life and to provide you with a comfortable, welcoming atmosphere that encourages personal growth.
Contact us today to schedule an appointment. We have special first-time offers for new clients and military members/veterans.


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Dear Housewives,
I have once again neglected you. Kit and I have been extremely busy over the past few months while starting our homemade compound butter business. (It's called Fundamentalist Butter. The Bountiful Blueberry butter is ah-mazing.) However, I have returned with a very important PUBLIC SERVICE ANNOUNCEMENT regarding the most excellent Wachowskis/Netflix extravaganza Sense8. I realize that I should have posted this PSA as soon as we watched the series last month. Oh, well. My apologies if you accidentally watched this show with your mom, dad, brother, sister, aunt, uncle or third cousins.
This is the warning for those who have not already been permanently scarred:
You know how when two ladies get it on using a strap-on and then afterwards one of them takes it off and throws it down on the hardwood floor and it's gloppy? That's in episode 1, housewives. Obviously, watching the scene itself is not traumatizing, but the aftermath of watching that with a relative could be devastating.
If you watch the first episode with your aunt, she will definitely wait to ask you about it and your own experience with sex toys while she's driving you down Highway 99 in her minivan. At that moment, you will calculate the odds of survival if you leap from a fast-moving vehicle and land, rolling into the ditch at the side of the road. The ditch will seem preferable to answering her questions.
Portman Doe


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GreenTechMedia, 13 June, 2017
Say you're a member of the world community and a signee committed to the Paris Agreement's long-term goals. You'd probably want to track your progress and assess your results.
You'd essentially be asking, "How well is the human race doing in its quest to transform its energy mix away from polluting sources?"
The answer is not so well, according to a new report from the IEA, Tracking Clean Energy Progress 2017, which looked at 26 technologies and their performance in meeting the 2°C Scenario (2DS) in 2025. (The 2DS is defined as "an energy system pathway and a CO2 emissions trajectory consistent with at least a 50 percent chance of limiting the average global temperature increase to 2°C by 2100.")
Only three of the 26 technologies are on track to meet that goal, while eight are significantly off-track and will need strong policy corrections to hit the 2DS.
The bright spots are:
Failing grades go to:


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Top 10 ophthalmology articles of 2016
Ophthalmology news in 2016 ran the gamut from important drug trials and approvals to studies regarding the cause and treatments of a multitude of ailments.
Here are the top 10 most read stories in ophthalmology this year on Healio.com:
1. FDA approves Raindrop near vision inlay for presbyopia
The U.S. Food and Drug Administration has approved the Raindrop near vision inlay for implantation in the cornea to improve near vision in some patients with presbyopia. Read more.
2. OSN Premier Surgeon 300 Innovators in Refractive Cataract Surgery
What is the Premier Surgeon 300? Simply stated, the Premier Surgeon 300 is a list of premium refractive cataract surgeons the editors and publisher have identified as leading innovators in the field of refractive cataract surgery. Read more.
3. Xiidra first FDA-approved drug for signs and symptoms of dry eye disease
The FDA approved Xiidra for the treatment of signs and symptoms of dry eye disease in adult patients on July 11. Read more.
4. Lampalizumab offers realistic hope for atrophic AMD
Lampalizumab may offer hope for people affected by atrophic age-related macular degeneration. Phase 3 trials are ongoing, and research is focusing on identifying patients who may better respond to the treatment. Read more.
5. FDA approves Avedro's cross-linking system for progressive keratoconus
The FDA has approved the KXL System and two photoenhancers for corneal collagen cross-linking treatment of progressive keratoconus, according to a press release from Avedro. Read more.
6. FDA approves Tecnis Symfony IOL for cataracts
The FDA has approved the Tecnis Symfony IOL for the treatment of cataracts, Abbott announced in a press release. The approval includes the Tecnis Symfony Toric IOL for people with astigmatism. Read more…….
More: http://www.healio.com/ophthalmology/news/online/%7B024394b1-4a5d-4319-813c-c0999c67dc1d%7D/top-10-ophthalmology-articles-of-2016
Source: Healio