text:
Should Doctors Weigh Costs When Making Decisions?
University of Pennsylvania's Ezekiel Emanuel argues that doctors should consider price when considering treatment options, where the outcomes are the same. Steward Health Care System's Ralph De La Torre says that's unethical. They joined a WSJ panel on the cost of health care in America. Photo: Getty
This transcript has been automatically generated and may not be 100% accurate.
... I ... there's ... a certain costs when they are making a medical decision ... absolutely ... me be very clear what I mean by that the colleges ... cure for cancer patients ... we are lots of just give you an example ... of stomach cancer ... you look at the guidelines ... don't want the flavors were more of chemotherapy and they will produce the same survival ... I ... the difference between those wanting flavors of chemotherapy ... for six cycles of chemotherapy roughly six months ... while the dollar to fifty five thousand now ... BT I hold the risen Christ ... exactly the same outcome ... now why should I consider the rights ... in that context ... where there's not a difference in outcome ... so when you have interventions that are exactly the same and there are plenty of that ... why should you might be an important component of your decision making ... well I think that's a theory legitimate ... consideration ... um I think ... it's something that we got to be quite clear about ... aam and so that's ... the theory is the case ... but that's all lot of cases like that in American medicine ... another one ... there are eighty ... six ... it is laughable artificial ... in any given market place there vastly different prices for the very affordable people leaving the actual cost ... every second boring about rationing of care The and that is the rationing of care what what I just set it with the outcomes of the St ... right ... that's exactly the Asean worm point twice that I wanted to be Beery careful here ... that's not mentioning the ... colors are saying we're not asking a patient ... all in six months longer willing to get cheap stuff ... that's not ... where we had the gall that is not an issue ... that we get to confront this point in time and it's not a matter of rationing ... I'm talkin' bout with the outcome of the same but the repeated so there's no confusion out there ... and you know the Segway ... the the the the the same cost actually ... the when you when you go ... out to the shops and fitted out in two ... thousand an hour in the same crowd ... and the costs of Nestle different ... well I think it into perspective you know I mean I think it does ... even with all due respect e e e e e ... you wanted you to ... me I mean ... short and you can go in some cases where that is to win the conference ... and the obvious ... but that's not been easy dilemma between pieces this time at the heart of what is it worth paying an extra hundred thousand live treatments or when two hundred thousand listings ... where millions live two years ... that's the dilemma between million and find some in the future taxable and ... we need to start ... thinking about ... any theme park doctors in a position ... at the isn't that ... basically when advocating our role in society and that the people we elect ... to make those tough decisions ... and were putting it in and of disease condition should be a good ... term for a deer caught ... can you imagine the news and independent are in public and Chinese ... I'm sorry to you know you have to start managing every case defending every person based on cost how long is can it be ... don't be a tremendous up for this country ... I think a good one disagrees with that comparative effectiveness research ... U S thinking the same as being part of ... your ... understanding costs and making decisions based on cost our investors and that is it pure basic compared to this research I would not to be one with wings and completely with what he said ... the tufted on the level we really talk about we talk about ... decisions be in line cost was asking physicians ... to make decisions as to ... what is the high end value of all why millionforty is the hundred thousand million as it out ... when you buy ... it you're buying a new phase of thousand dollars to get you glued to six months ago but he was a great ... that cost a hundred million everybody would say that's crazy ... the data to find a society its alright that doctors and nurses in position to make those decisions just as we know ... what ... so what's were Copel little grilled in most cases you will so people are suffering from ... life threatening chronic pain for example ... there are a lot to win streak of good we observed when you look at the data due for an appealing one of ... the venture to these enormous giants ... the patterns are a function of how physicians are trained or what ... technologies as the supply side of the table says to the survey will tell ... and these are things that can be your trust I think with all reason and ethical problems broadly ... described in these debates Robles always taken to the streets ... of the end of life care of ... it a lot of his other very valid very pressing conditions but ... in the middle there all kinds of Sokol circumstances with tremendous resource expenditure ... think of the restless with the fairly easily and audit the Eagles because you ... can ... debate the patient have some responsibility for the marginal nature of that decision ... and what are the sort of like taking the BBB the emergency room to light with the story are ... or will I call him to the nurse that ... Obama's cutting provides the CIA by relieved to begin with ... over his remarks ever ... these are the cases that are or think are much more ... avoid the space is because the ... compass passes we can tell right ... that's right um different you know and and ... I would use it I think actually the ... situation I just thought well maybe most ... apparent in the ... gastric cancer case and I gave you is not at all ... on ... the back extreme we have lots of cases where ... different ... kinds of KR ... result in the same outcome ... as best as we can tell the price differences are very high and ... why do we tolerate ... any expenditure when you can get the same outcome ... Lindsey is the ... in some cases and colleges serve and please them more expensive chemotherapy returned from a vice I agree with the manufacturer ... so they've got a choice of eighteen ... am the one that is fifty five the enticing them in the right way so the structure of the reimbursement ... and the way you you you pay for it will have a dramatic Shanghai and the biggest opportunities that if a bank or ... does every time Medicare changes of name will ... provide the right and so we did or did it because the Lord to spare we have ... well I guess I actually read you and I get to the issue well for a long time we have to shift off the fee for service system ... the fee for service system ... and ... in medicine Justice in any other area is ... you pay people to do to our ... suprise ... still do more ... I'm we got the medicine ... and it's a ... serious problem it's not the only probably get


text:
|Oracle FAQ
|Your Portal to the Oracle Knowledge Grid
Home -> Community -> Mailing Lists -> Oracle-L -> RE: Google's architecture -- was Re: paging and google.com
Hmm... gives me something to work on... I've got the name to go with it too...
"Before we look at your boring data, Bambi recommends you check this HOT HOT HOT XXXInfo!!"
Gives a whole new meaning to Relational Database.
-----Original Message-----
Sent: Friday, September 26, 2003 11:50 AM To: Multiple recipients of list ORACLE-L
Google like behavior in oracle queries? On top of real results you get "paid
placement" entries, some of them
X-rated? That'll be the day.
Mladen Gogala
Oracle DBA
-----Original Message-----
Hemant K Chitale
Sent: Friday, September 26, 2003 12:40 PM To: Multiple recipients of list ORACLE-L
I'm confused. Does Tom Kyte actually say that Google uses Oracle or is he talking of "google-like behaviour" in Oracle queries ? Hemant
At 07:24 AM 26-09-03 -0800, you wrote:
http://tinyurl.com/ordz <http://tinyurl.com/ordz>
-----Original Message-----
Sent: Friday, September 26, 2003 11:00 AM To: Multiple recipients of list ORACLE-L
hmmm. must have read it wrong in the book. any idea how to get the 'estimated number of record returned?
Hemant K Chitale
Oracle 9i Database Administrator Certified Professional My personal web site is : http://hkchital.tripod.com <http://hkchital.tripod.com/>
This message is for the named person's use only. It may contain confidential, proprietary or legally privileged information. No confidentiality or privilege is waived or lost by any mistransmission. If you receive this message in error, please immediately delete it and all copies of it from your system, destroy any hard copies of it and notify the sender. You must not, directly or indirectly, use, disclose, distribute, print, or copy any part of this message if you are not the intended recipient. Wang Trading LLC and any of its subsidiaries each reserve the right to monitor all e-mail communications through its networks. Any views expressed in this message are those of the individual sender, except where the message states otherwise and the sender is authorized to state them to be the views of any such entity.
Please see the official ORACLE-L FAQ: http://www.orafaq.net
Author: Bellow, Bambi
INET: bbellow_at_chi.navtech.com
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Original text of this message

subset: commoncrawl


text:
health professional inserts a vaginal speculum into the vagina, then gently
spreads apart the vaginal walls. This allows the health professional to examine
the inside of the vagina and the cervix.
Last Revised:
May 18, 2011
Healthwise Staff
Medical Review:
Sarah Marshall, MD - Family Medicine & Femi Olatunbosun, MB, FRCSC - Obstetrics and Gynecology
This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
To learn more visit Healthwise.org
© 1995-2012 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.


text:
Search arrangements;IMPOSSIBLE REMIX - "Show Yourself" Frozen 2
Icarus: Alien Vanguard OST Arachno SoundFont
Eternal DOOM OST Arachno SoundFont
Dune OST MIDI conversion Arachno SoundFont
New Cover
Made by Ronald Karle.
Arrangement information
Source: Original music
Title: The Heart of my Love
Composer(s): Ronald Karle
Released on: 03-01-2019
Duration: 04:30
Original song information
Original track's title: The Heart of my Love
Year: 2019
Arachnosoft - Version 10.8 - Copyright © 2000-2020 Maxime Abbey. All rights reserved. Any reproduction is forbidden without authorization.


text:
Baby Gear
Car Seats
Bedding & Décor
Bath & Potty
The Embassy High Chair offers you unsurpassed value as a handsome, wood high chair with extended use up through adulthood! Comfortable and convenient, it's a complete high chair for your baby, a booster chair for your toddler and preschooler, and eventually an attractive kitchen or desk chair for tweens, teens, and adults.
Includes two feeding trays.Main wood tray is covered by a dishwasher safe, plastic tray. Wood tray is fixed and features one spacious compartment with a lip around outside edge -- handy for playtime and snacktime. Removable plastic tray has cup holder and large main compartment.Five-point harness system is securely attached to the seat panel. Harness straps are adjustable at the waist and shoulders.The included padded seat cushion has removable and washable fabric cover. Seat cushion cover is made with 65% polyester/35% cotton fabric and can be machine washed. Seat cushion is made with PEVA (non-PVC) vinyl.The Embassy is for use from approximately six months (when your child can sit unassisted) to a maximum weight of 175 pounds.Adult assembly required.Dimensions with tray: 32.75"H x 17.5"W x 20"DInterior width of the seat is 16.25 inches.Height from top of seat to the floor with the seat in the top slot is 24 inches.Height from top of foot panel to the floor in the lowest slot is 10 inches.Product weight: 15 lbs.IMPORTED
Returning your online order to a store is easy! Bring your shipment confirmation email to a store near you. A store associate will scan the shipment confirmation email. The items that are returned will be refunded to the original method of payment (excluding Paypal). Learn more about our Return Policy
Be the first to hear about new arrivals and in-store specials, get style tips, and more.
Watch your inbox for new arrivals and in-store specials, style tips, and more. Manage your emails settings Not registered yet? Sign up for email updates here.
Styles, selections, prices and availability may vary by stores and at Burlington.com
† "Up to" comparable value savings percentages are based on initial assortment offerings; supplies are limited and our inventory is always changing.


text:
What is ricin?
Ricin is a protein toxin that is readily produced from castor beans (Ricinus communis), which are ubiquitous throughout the world. It acts as a cellular poison by inhibiting protein synthesis. Naturally-occurring cases of ricin involve ingestion of castor beans, and are marked by severe gastrointestinal symptoms, vascular collapse, and death.
How is ricin associated with Bioterrorism?
Ricin has been used as a biological weapon for assassinations in the past. It is toxic by numerous exposure routes, however, its use by bioterrorists might involve poisoning of water or foodstuffs, inoculation via ricin-laced projectiles, or aerosolization of liquid ricin or lyophilized powder. Waste from the commercial production of castor oil contains 5% ricin, making it easy for such a substance to fall into the hands of bioterrorists.
What are the signs of ricin intoxication?
When inhaled as a small particle aerosol, ricin would likely produce symptoms within 8 hours. Fever, cough, difficulty breathing, nausea, and chest tightness are followed by profuse sweating, skin turning blue, low blood pressure, and finally respiratory failure and circulatory collapse. Time to death would likely be 36-72 hours, depending on the dose received.
How is ricin intoxication diagnosed?
The diagnosis of ricin is largely based on symptoms and should be suspected in a setting of mass casualties with a similar and appropriate clinical picture. Failure to respond to antibiotics helps to differentiate ricin exposure from lung infections produced by bacterial agents. A blood antibody test exists but is not readily available.
Can ricin intoxication be treated?
No specific treatment exists, and care is thus supportive treatment of symptoms.
Is a vaccine available?
No specific vaccine or antitoxin exists. A protective mask would offer protection from aerosol exposure


text:
absolutelydriven needed a new logo design and created a contest on 99designs.
A winner was selected from 5 designs submitted by 3 freelance designers.
I have a new vBulletin forum that is automotive based that needs a header and logo design
The Mid-Atlantics Premiere Automobile and Lifestyle Forum
Desired Color Scheme:
dark grey, steel blue, red, yellow
Desired Style:
modern, clean, upscale
Accepted File Formats:
Standard Web Formats (.jpg, .gif or .png); Vector Formats (.eps, .pdf or .ai); Layered Formats (.psd or .tiff)
I am starting a new vBulletin forum that is automotive based. The majority of the members will be higher net worth individuals ages 25-45 with European vehicles ie Porsche, Audi, Mercedes, BMW etc. I do NOT want the specific vehicle manufacturers in the header for obviouls legal reasons. The name of the forum is the name of the business, AbsolutelyDriven.com because we are a group of individuals that are absolutely driven in our business ventures, our passions and our hobbies. The sites niche is that its regionally based in the Mid-Atlantic region and does car shows and events.
- I want the tag line "The Mid-Atlantics premiere automobile and lifestyle forum" in the vBulletin header - incorporate an illustrated "finish line flag" into the vBulletin header design - incorporate an illustrated tachometer into the logo design somehow - mirroring in the logo - this will lead to more graphic design work
- for header dimensions please see my buddys site http://www.bimmerpages.com/forums Â
Find out how a design contest works or learn more about our logo design services.


text:
You don't have any saved vehicles!
Look for this link on your favorites:
Once you've saved some vehicles, you can view them here at any time.
WAS $15,749, $900 below NADA Retail! CARFAX 1-Owner, Spotless, Nissan Certified, ONLY 32,670 Miles! CD Player, Keyless Start, Smart Device Integration, Bluetooth, Aluminum Wheels, Back-Up Camera, iPod/MP3 Input. READ MORE!BUY WITH CONFIDENCE: 7-year/100,000-Mile Limited Warranty, 24-Hour Roadside Assistance and Towing Assistance, includes rental car reimbursement, Rental Car, Trip-Interruption Services, Vehicle Title Insurance Policy, CARFAX Vehicle History Report, along with the CarFax 3-year Buy Back Guarantee, $50 Deductible, Inspection completed by Nissan technicians, and factory-authorized parts are used when necessary. SiriusXM Satellite Radio with 3-month trial subscription, Certified warranty is honored at any Nissan dealer nationwide, Certified warranty is transferable when sold from one private party to anotherA GREAT TIME TO BUY: Reduced from $15,749. This Altima is priced $900 below NADA Retail. Approx. Original Base Sticker Price: $24,500*.KEY FEATURES INCLUDE: Back-Up Camera, iPod/MP3 Input, Bluetooth, CD Player, Keyless Start, Smart Device Integration Rear Spoiler, MP3 Player, Keyless Entry, Remote Trunk Release, Steering Wheel Controls. Nissan 2.5 SR with Pearl White exterior and Charcoal interior features a 4 Cylinder Engine with 182 HP at 6000 RPM*. WELL MAINTAINED VEHICLE, WELL MAINTAINED VEHICLEVEHICLE REVIEWS: The CVT is more responsive when you press on the gas pedal compared to its competitors, and the simulated stepped gears reduce some of the engine drone that others suffer from. -Edmunds.com. Great Gas Mileage: 37 MPG Hwy.WHY BUY FROM US: Whether you're searching for a new or used car in Philadelphia, researching financing options, or looking for a quick quote on a vehicle, our friendly, professional staff is ready to provide you with all the help you need Please confirm the accuracy of the included equipment by calling us prior to purchase.
At Faulkner Nissan Jenkintown, we believe in offering great customer service from the moment you walk through our doors. Whether you're finding, buying, or maintaining a Nissan, we'll be ready and willing to help. Below, we'll explain how we continue to serve drivers like you in the Jenkintown, Abington, Glenside, and Philadelphia areas. Read all about our dealership, and contact us if you have any questions.
New vehicle pricing includes all offers and incentives. Tax, Title and Tags not included in vehicle prices shown and must be paid by the purchaser. While great effort is made to ensure the accuracy of the information on this site, errors do occur so please verify information with a customer service rep. This is easily done by calling us at (215) 887-8870 or by visiting us at the dealership.
**With approved credit. Terms may vary. Monthly payments are only estimates derived from the vehicle price with a 72 month term, 5.9% interest and 20% downpayment.
*Number of views in last 30 days
† Pricing includes Manufacturer rebates and/ or dealer discounts. Must finance with Nissan Motor acceptance to qualify. All manufacturer incentives and rebates included in payment. Dealer/Customer Incentives may not be combined with special APRs or leasing; customer must use standard rates to receive Dealer/Customer Cash incentive unless otherwise stated.
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(215) 607-2466Call Now
900 Old York Road • Jenkintown, PA 19046Get Directions
Open Today! Sales: 9am-8pm
Open Today! Service: 7:30am-7pm
Open Today! Parts: 8am-7pm
Phone: 2152449300http://maps.google.com/?q=900%20Old%20York%20Road%2C%20%2C%20PA%20%20US%2C%20Jenkintown%2C%20PA%2019046


text:
From Openembedded.org
Here is my history as programmer: - 1997 simple file manager,
Program language - Pascal;
- 1997 small graphical editor for BMP-files.
Pascal with ASM blocks -> using mouse.
- 1997-1998 School project for courses of Informatic.
Program language - Pascal. Name of project game "Monopoly" Code part - developing all process with graphic interface and game design, unique graphic file format for this project, 3D effects in game.
- 1998-1999 Program for recruitment.
(The terms of reference were given by psychologist for recruitment) Description: This program was a test. You had to choose a set of favorite colors. Each color should be recorded under code and saved for analysis in a summary table. Table then sent to analysis of recruiters. Code on C++ & ASM.
- 2005-2006 develop CAD-program for collect statistic data for sites (radio base stations).
Program was written on VBA for MS Access.
- than little sketches for Excel, same VBA. (periodically back to this till present) - three years ago start learn Java (ME), was written few programs for my mobile phone. Played with this few month.


text:
Measuring social commerce
True social commerce promises to leverage the speed and connectivity of social networks to drive sales transactions. It's an elusive promise that many companies have struggled to realize, but those that do will disrupt industries and create a new scale of business.
With "Social Commerce: A First Look at the Numbers," Eventbrite is unveiling the first tangible data to quantify the value and impact of social media in driving eCommerce. We are tracking a new set of metrics that measure social commerce success and are excited to share them with the industry. In doing so we hope to spark conversation and begin to set standards and benchmarks around this new marketing channel.
Events are inherently social. When people buy tickets for an event, they want to share the experience – and the news – with friends. The social Web fuels the conversation and the communities that arise around live events. This conversation isn't new, but we are now able to track the resulting transactions with unprecedented granularity.
Eventbrite's web-based service is the simplest, most effective way to publish events and sell tickets online. Deep and growing integrations with the major social networks mean that the power to drive organic social distribution is finally in the hands of event organizers and attendees. Eventbrite's tools tap into the world's overlapping social graphs to spread event news and purchase behavior. These tools are built specifically to empower organizers and attendees alike to turn events into truly social experiences.
For the purposes of this report, Eventbrite defines social commerce as transactions that are driven through sharing on social platforms such as Facebook, Twitter and LinkedIn and through email sharing via the Eventbrite "email friends" application.
Key findings
The key findings of our analysis include:
- Sharing equals transactions: Dollars per share
When someone shares an event with their friends through social media, this action results in real dollars. Our most recent data shows that over the past 12 weeks, one share on Facebook equals $2.52, a share on Twitter equals $0.43, a share on LinkedIn equals $0.90, and a share through our "email friends" application equals $2.34. On an aggregate level across Facebook, Twitter and LinkedIn, and our email share tool, each share equals $1.78 in ticket sales. We're seeing this number improve every week with the most recent four-week average equaling $1.87.
- It's extremely sticky: Visits per share
The hyper-relevancy of the social graph breeds deeper engagement, greater sales and stickier audiences. For Eventbrite, Facebook is now the #1 referring site for traffic to the company's site, surpassing Google as people discover events that their friends are sharing and they click through to find out more. On average each Facebook share drives 11 visits back to Eventbrite.com. Averaging across all channels, one share drives over 7 visits back to Eventbrite.com.
- It's happening everywhere, across all sizes and types of events: Consistency of sharing
Sharing is consistent across event size. Sharing occurs at the same rate an event has 10 or 10,000 people. Classes/workshops and networking events have the most share activity, followed by fundraisers, conferences, and music events.
What it Looks Like
How we did it
We use a custom suite of social analytics tools that we have developed entirely in-house. Our reporting lets us track and analyze not only which sharing options our users leverage, but where on our site each share action takes place. These tools also tie back into our conversion funnels, so we are able to attribute ticket purchases to the specific social distribution channel that drove them. So, for example, we can compare not just the value created by a Facebook "Like" vs. a tweet, but also the performance of shares initiated before or after a purchase.
Summary: Social commerce is the next big thing
Social commerce takes online commerce to a new level. It marries the natural act of sharing and socializing with friends and the act of buying something online. Social commerce brings together social promotion and transactions into a single, unified experience, which breaks the old rules of eCommerce and demands new metrics. And the exciting news is that this is just the beginning. Look for more reports from Eventbrite in the coming months. We're also keen to hear your thoughts and feedback on the subject.


text:
Dark Cherry and Amaretto Ice Cream
- Yield: 1 1/2 Quarts
- 2cups whole milk
- 2cups granulated sugar
- Pinch of Kosher salt
- 1 vanilla bean bod, deseeded
- 2cups heavy whipping cream
- 1/2cup dark cherries, pitted and quartered
- 1teaspoon amaretto liqueur
- In a medium saucepan over medium heat, combine milk and sugar. Stir occasionally until the sugar completely dissolves and tiny bubbles form around the edges of the pan. Take off the heat, and add the salt and vanilla seeds along with the vanilla pod to the milk and sugar mixture. Allow to steep and cool for at least 10 minutes.
- Whisk in the heavy whipping cream and discard the vanilla bean pod. Cover and place in the fridge for a few hours until completely chilled, at least 2 hours.
- Using an ice cream maker, add the chilled ice cream base to the machine and freeze according to the manufacturer's instructions. Once the mixture has thickened, add the cherries and amaretto. Once the machine has finished, scoop the ice cream into a freezer proof container and freeze for at least 2 hours. Enjoy!
For more from Amber, try her Peach and Basil Ice Cream, Backyard Mint Ice Cream and Blackberry and Local Honey Ice Cream and visit her at For the Love of the South.


text:
Back to results
Paal 8 Hotel aan Zee - familiesuite 150 M2
Make your choiceEvery date with a price is available.
January 2020
Price survey
Make your choice and select a date in the calendar for a price list.
Attention: Red is unavailable and green is available. If there is no price in the green calender please try a different period or date. By no results please contact us by e-mail: email@example.com or by Phone on 0031562-443000.
Prefer to book by phone?
Please keep the following code number ready, so we will be able to assist you as efficiently as we can.
Phone VVV Terschelling:: (0031) (0) 562-443000.


text:
- Floyd Mayweather Jnr v Miguel Cotto
Mayweather plans to retire in two years
Floyd Mayweather Jnr is confident that his legacy has been secured even if he fails to meet Manny Pacquiao before retiring at the age of 37.
Pacquiao's name has dominated the build-up to Mayweather's recent fights, and negotiations between the pair broke down earlier this year, before Mayweather agreed a bout against Miguel Cotto on May 5.
But Mayweather, 35, has insisted that he is not fazed by the prospect of never taking on Pacquiao, and the unbeaten American will not lose any sleep if the pair fail to face-off.
"If it really was all about Pacquiao then I didn't have to fight all 42 opponents [I have faced so far]," Mayweather said. "All I had to do was come to the sport of boxing and fight one guy then I would have gone down as the best, just one guy. So I guess the 42 guys that I've faced didn't count.
"But I want to stay active, I want to fight again in 2012 before the year is up. I want to constantly go out there and test my skills and I want to continue to push myself to the limit. I still plan to retire at 37 - but I want to fight plenty of times before then."


text:
LOS ANGELES (thefutoncritic.com) -- The latest development news, culled from recent wire reports:
Looking to keep track of all the various projects in development? Click here to visit our newly revamped "Series in Development" charts. Visitors can now filter our listings by network, genre and even development stage (ordered to pilot, cast-contingent, script, etc.). It's updated every day!
BLIND JUSTICE (ABC) - Viewers on the west coast will get the chance to see the show's until-now-unaired finale ("Fancy Footwork") tomorrow night at 10:00 p.m. (Pacific Time) following Game 6 of the NBA Finals.
FAMILY GUY (FOX) - 20th Century Fox Home Entertainment will release "Family Guy Presents Stewie Griffin: The Untold Story," an original feature-length DVD of the recently resurrected animated series on Tuesday, September 27. The 83-minute installment is comprised of three interconnected episodes from the show's fourth season that have yet to air ("Stewie B. Goode," "Bango Was His Name Oh" and "Stu & Stewie's Excellent Adventure") in which Stewie, the maniacal baby genius, sets out on a road trip to find his real dad after a near-death experience. The single-disc release will also include audio commentary, deleted scenes and other bonus features. More than 4 million units of the three "Family Guy" DVD releases have been sold thus far, generating more than $100 million in revenue.
LOVE, INC. (UPN) - Warren Littlefield (and his Littlefield Co.) is setting up shop at Touchstone Television after four years at Paramount Network Television, where he executive produces the upcoming UPN comedy "Love, Inc." The move is part of a new two-year pact Littlefield has signed with Touchstone, which takes effect on July 1. It's not clear how or if the deal will affect the company's involvement on "Love, Inc."
Sources: Variety, The Hollywood Reporter, Reuters


text:
Anacor Pharmaceuticals Announces Positive Results from the Second Phase 3 Trial of Tavaborole for On
Anacor Pharmaceuticals Announces Positive Results from the Second Phase 3 Trial of Tavaborole for Onychomycosis
Anacor Will Host a Conference Call Today at 5pm ET to Discuss Results
PALO ALTO, Calif.--(BUSINESS WIRE)-- Anacor Pharmaceuticals (NAS: ANAC) today announced positive preliminary results from the second of two Phase 3 trials of tavaborole (known as Study 302). Tavaborole is a topical anti-fungal for the treatment of onychomycosis, a fungal infection of the nail and nail bed that affects approximately 35 million people in the United States. Results from the first Phase 3 trial (known as Study 301) were announced on January 29, 2013. In both studies, tavaborole achieved statistically significant and clinically meaningful results on all primary and secondary endpoints.
"We are pleased with the results of this study and we are on track with our plans to file an NDA in the middle of this year," said David Perry, Chief Executive Officer of Anacor. "In both Phase 3 trials, tavaborole demonstrated better efficacy than ciclopirox lacquer, the only approved topical treatment for onychomycosis. Importantly, ciclopirox lacquer requires concomitant nail debridement. If approved, tavaborole could offer patients and prescribers a safe, effective and convenient topical treatment option for onychomycosis."
"In Study 302, tavaborole achieved a complete cure rate of 9.1% in a patient population that we believe represents the majority of onychomycosis patients. In both of our Phase 3 studies, we allowed enrollment of adult patients of all ages who had up to 60% of their toenail affected by disease. While older patients and those with more extensive disease may be tougher to treat, we believe they represent an important and significant segment of the patient population. Approximately fifty percent of people over the age of 70 have onychomycosis, and often patients don't seek treatment until the infection has progressed and involves a significant portion of the nail," said Lee Zane, MD, Vice President of Clinical Development of Anacor. "In addition, 27.5% of patients in Study 302 achieved a completely clear or almost clear nail, which is a very meaningful endpoint to physicians and patients because it represents an excellent clinical response."
The results at week 52 for each of the Phase 3 studies are summarized in the table below:
Study 301
|Study 302
|(active / vehicle)
|(active / vehicle)
|Primary Endpoint
|"Complete cure" (a composite endpoint that requires both a completely clear nail and mycological cure)
6.5% / 0.5%
9.1% / 1.5%
|Secondary Endpoints
|"Completely clear" or "almost clear" (≤10% clinical involvement) nail
26.1% / 9.3%
27.5% / 14.6%
|Mycological cure (the absence of fungus as determined by a negative potassium hydroxide ("KOH") examination and a negative fungal culture)
31.1% / 7.2%
35.9% / 12.2%
|"Completely clear" or "almost clear" nail with mycological cure
15.3% / 1.5%
17.9% / 3.9%
|Other Results
|Negative fungal culture
87.0% / 47.9%
85.4% / 51.2%
|"Completely clear" or "almost clear" nail and negative culture
24.6% / 5.7%
25.3% / 9.3%
Tavaborole Phase 3 Study 302 Design
Study 302 enrolled 601 patients in the United States and Canada, randomized two-to-one to receive either tavaborole, 5% solution or vehicle. Eligible patients were at least 18 years of age (with no upper age limit) with a clinical diagnosis of distal subungual onychomycosis involving 20% - 60% of the total area of the target great toenail and positive mycology. Patients were instructed to apply tavaborole solution or vehicle to the target great toenail once daily for 48 weeks. Study 301 had an identical design but enrolled patients in the United States and Mexico. Anacor received a Special Protocol Assessment from the FDA on all major parameters of Studies 301 and 302, including study endpoints.
Overall, tavaborole was safe and well-tolerated across study subjects. There were no serious adverse events related to study drug. The rate of discontinuations as a result of adverse events was low (0.8% for tavaborole and 0.5% for vehicle) in Study 302.
Conference Call and Webcast
Anacor will host a conference call today at 5:00 p.m. ET / 2:00 p.m. PT to discuss these results. The call can be accessed by dialing (877) 291-1367 (domestic) and (914) 495-8534 (international) five minutes prior to the start of the call. The call will also be webcast live and can be accessed on the Events and Presentations page, under Investors, on the company's website at http://www.anacor.com and will be available for three months following the call.
About Anacor Pharmaceuticals
Anacor is a biopharmaceutical company focused on discovering, developing and commercializing novel small-molecule therapeutics derived from its boron chemistry platform. Anacor has discovered eight compounds that are currently in development. Its two lead product candidates are topically administered dermatologic compounds — tavaborole, a topical antifungal for the treatment of onychomycosis, and AN2728, a topical anti-inflammatory PDE-4 inhibitor for the treatment of atopic dermatitis and psoriasis. In addition to its two lead programs, Anacor has discovered three other wholly-owned clinical product candidates — AN2718 and AN2898, which are backup compounds to tavaborole and AN2728, respectively, and AN3365 (formerly known as GSK2251052, or GSK '052), a systemic antibiotic for the treatment of infections caused by Gram-negative bacteria, which previously was licensed to GlaxoSmithKline LLC, or GSK. GSK has returned all rights to the compound to us and we are considering our options for further development, if any, of this compound. We have discovered three other compounds that we have out-licensed for further development — two compounds for the treatment of animal health indications that are licensed to Eli Lilly and Company and AN5568, also referred to as SCYX-7158, for human African trypanosomiasis (HAT, or sleeping sickness), which is licensed to Drugs for Neglected Diseases initiative, or DNDi. We also have a pipeline of other internally discovered topical and systemic boron-based compounds in development. For more information, visit http://www.anacor.com.
Forward-Looking Statements
This press release may contain forward-looking statements that relate to future events including the development of tavaborole, timing for filing of a new drug application, or NDA, related to tavaborole and the potential for approval and commercialization of tavaborole. These forward looking statements involve known and unknown risks, uncertainties and other factors that could cause actual levels of activity, performance or achievement to differ materially from those expressed or implied by these forward-looking statements, including risks related to the planned NDA filing, risks from competition for tavaborole (in particular efinaconazole from Valeant Pharmaceuticals International Inc.), whether the information of the key opinion leaders is representative of the behavior and opinions of other investigators, risk of unforeseen side effects and risks related to regulatory approval and commercialization of new drug candidates. These and other risks are described in more detail in Anacor's Annual Report on Form 10-K for the year ended December 31, 2011, filed with the Securities and Exchange Commission under the heading "Risk Factors" and Anacor's subsequent Quarterly Reports on Form 10-Q. These statements reflect the views of Anacor as of the date of this press release with respect to future events and, except as required by law, it undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise after the date of this press release.
Anacor Pharmaceuticals
DeDe Sheel, 650-543-7575
Director, Investor Relations and Corporate Communications
KEYWORDS: United States North America California
The article Anacor Pharmaceuticals Announces Positive Results from the Second Phase 3 Trial of Tavaborole for Onychomycosis originally appeared on Fool.com.Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.
Copyright © 1995 - 2013 The Motley Fool, LLC. All rights reserved. The Motley Fool has a disclosure policy.


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This new offering from CLAAS generated a huge response from the visiting farming community. Mr. Prem Kumar, National Sales Head, CLAAS in India, was present during the display. Apart from this machine, CLAAS also displayed its other advanced and popular agri-machinery like DOMINATOR 40 track-type combine harvester and JAGUAR 25 tractor mounted forage harvester. Dharwad Krishi Mela is one of most visited agri-machinery exhibition of India. Approx. 5-6 Lakh farmers throng the event to get a glimpse of the latest technologies available in Indian agri-machinery space.
CROP TIGER 40 Multigrain amazes farmers
Augmenting its success story in Southern India, CLAAS in India launched its combine harevster - CROP TIGER 40 Multigrain with Maize header, at the prestigious UAS Dharwad Krishi Mela.


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Hey there, time traveller!
This article was published 23/11/2012 (2615 days ago), so information in it may no longer be current.
A Winnipeg man tried to swindle thousands of dollars from two British teachers he convinced to send him nude photographs and videos through an online dating website.
Robert Li, 33, used the naughty material as the basis for his threats, claiming he would reveal them to the victim's schools and colleagues if they didn't meet his financial demands. It's one of the first cases of its kind ever exposed in Manitoba.
"It will take some money to make sure these videos never see the light of day," Li told one of his victims in an email exchange later seized by police.
Li — who used a bogus last name on the "Plenty Of Fish" website — also spun an elaborate tale about his father being $150,000 in debt to Asian gangs who were after him if the payment couldn't be made quickly. He befriended the women quickly by claiming he was planning his own move to London in the near future.
Nothing could be further from the truth. He was living in the basement with his parents, still smarting from being laid off with his job with Investors Group. There was no gang debt, no angry mobs after his family. Just a devious plot to make some cold, hard cash.
"I feel remorse for my actions. I've caused both ladies emotional pain and stress," Li told court Friday at his sentencing hearing. He has pleaded guilty to a rare charge of extortion by libel. The Crown is seeking a six-month conditional jail sentence, while Li has asked for a suspended sentence with probation.
Provincial court Judge Carena Roller has reserved her decision until Dec. 13.
The two victims are unknown to each and didn't realize they were both being manipulated over a week-long period around the same time last September, court was told. Li turned the otherwise tame conversations sexual by sending them faceless photos which purported to show him naked. He then encouraged the two women to do the same.
"I started to trust Rob. He said he was moving to London and I started to see a future for us," one victim told police. She was coming off a nasty divorce and said she turned to Plenty Of Fish to see if "men still found me attractive and as a confidence boost."
Li certainly talked a good game, taking their conversations to other websites such as Skype which allowed for video interaction. Only days after first meeting online, she was suddenly performing a sexual striptease for him. She had no idea Li was recording on the other end of the computer to use it against her.
"I feel like an idiot. I never thought this would happen," she later told police. "I thought this would be a personal video between the two of us."
Li had initially told the woman he would meet her in London in the coming days — but then claimed gang members had attacked him because of his father's debt, stolen his passport and claimed more "blood would be shed" if he didn't come up with the cash quickly.
"Do you value your job?" Li suddenly asked the woman in an online chat. "Pretty sure the school wouldn't like videos of their teacher floating around on the Internet."
The woman claimed she didn't have the funds because of the costs of her ongoing divorce. Li told her to go apply for a loan.
"You have an hour to decide before I send these to your school," he threatened.
The second victim had a similar encounter with Li, sending him photos of her in lingerie and fully nude on the belief they were private. Once obtained, Li quickly turned on her and demanded money - even suggesting she sell her horse to get funds for him.
"I know where you work," he said in one chat. "You're going to regret that I have the pictures and the videos."
Both women went to police, who quickly linked the two incidents and contacted authorities in Winnipeg. Police arrested Li at his parents' house last December, where he admitted to his crimes but denied ever planning to expose the women as he had threatened.
"There'll be no other incidents like this. I'm not a bad guy," said Li.
Defence lawyer Sarah Inness said her client has no prior criminal record and simply got "caught up" in a scam.
"He very much regrets what he did. It was out of character for him," she said. Inness also expressed surprise the two victims would be so trusting of a total stranger by sending him explicit material within days of meeting online.
"I'm always amazed at the amount of privacy people give away on the Internet," said Inness.
Li has been free on bail since his arrest with conditions to have no contact with the women, avoid any online dating sites and not to use Skype. There have been no breaches, court was told.
Mike McIntyre
Mike McIntyre grew up wanting to be a professional wrestler. But when that dream fizzled, he put all his brawn into becoming a professional writer.
You can comment on most stories on The Winnipeg Free Press website. You can also agree or disagree with other comments. All you need to do is be a Winnipeg Free Press print or digital subscriber to join the conversation and give your feedback.
By submitting your comment, you agree to abide by our Community Standards and Moderation Policy. These guidelines were revised effective February 27, 2019. Have a question about our comment forum? Check our frequently asked questions.


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First meeting: Sept 18 at 7 am PACIFIC/10 am EASTERN TIME
Free for Kepler Students, $4.50 for others (to help pay for the classroom space)
Need more stimulation in the morning than your favorite caffeinated beverage? Join Joseph Crane to discuss his latest book, Between Fortune and Providence: Astrology and the Universe in Dante's Divine Comedy.
This book looks at Dante's Divine Comedy from an astrological perspective and discusses the relationship of astrological practice to that of divination, magic, and prophecy. We see that Dante's astrology is an expression of nature (and super-nature) that is ordered but subject to change, and, in the earthly realm, subject to decline and the need for regeneration. There are specific philosophical traditions underpinning The Divine Comedy's astrology - are these traditions also within modern astrology? We find that astrology itself, like Dante's great poem, also dwells between the turnings of personal Fortune and the purposeful universe of Providence.
About the Author
Joseph Crane studied philosophy at Brandeis University in 1976 and received his M.A. from Lesley University in integrated psychotherapy with an Independent Study degree. Joseph is a consulting astrologer, teacher, and author. He is the author of A Practical Guide to Traditional Astrology (1997), Astrological Roots: The Hellenistic Legacy (2007) and a number of published articles. He has taught philosophy, ancient mythology, and Hellenistic astrology at Kepler College. As cofounder of the Astrology Institute, Joseph has trained many people in modern and traditional astrology. He is also a psychotherapist and a Buddhist practitioner in the Tibetan Vajrayana tradition.


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StoryCorps Shorts: A Life Worth Living
Special | 2m 41s
MJ Seide never thought that she would live a happy, fulfilling life. Then she met her future partner, who at the time had been married to a man and raising children. MJ remembers how it felt to fall in love, and to get to know her new extended family.
Aired: 05/22/19
Expires: 05/23/23Video has closed captioning.
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Major funding for POV is provided by PBS, The John D. and Catherine T. MacArthur Foundation, the John S. and James L. Knight Foundation, Bertha Foundation, Marguerite Casey Foundation, Corporation for Public Broadcasting, National Endowment for the Arts and the New York State Council on the Arts, with special support from The Fledgling Fund.


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text: Hi, I'm Jessica! I am very passionate about photography, everything that I do revolves around my camera and taking photos. I have been a professional photographer for over 11 years and I still get excited about every shoot. I enjoy a good adventure and I try to bring that adventure into my shoots, by exploring the mountains, chasing the light and helping you relax in front of the camera! Thanks for stopping by, let's work together!


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My sports writing pal Matt Stephens of the Fort Collins Coloradoan has confirmed that former Colorado State tailback Donnell Alexander has transferred to the University of Akron, where he will play for Terry Bowden.
How's this for strange bedfellows:
At Akron, Alexander will join former Colorado Buffaloes quarterback Nick Hirschman, who transferred to Akron last year.
Bowden, of course, is the son of Florida State legend Bobby Bowden and also is a former Auburn coach and college football TV analyst.


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Garlic-Filled Meatballs
Family and friends will go wild for these "gourmet" meatballs. I also use the chutney to top baked chicken, steaks and burgers.
Total TimePrep: 30 min. + cooling Cook: 20 min.
Makes6 servings
- 4 whole garlic bulbs
- 1 tablespoon olive oil
- 1 egg, lightly beaten
- 1/3 cup dry bread crumbs
- 1 teaspoon salt
- 1 teaspoon pepper
- 1-1/2 pounds ground beef
- 3 bacon strips, diced
- 1-1/4 cups thinly sliced sweet onion
- 1 to 2 tablespoons red wine vinegar
- 1-1/2 teaspoons sugar
- Dash pepper
- 1/3 cup crumbled goat cheese
- Toasted French bread slices (1/2 inch thick), optional
- Remove papery outer skin from garlic (do not peel or separate cloves). Cut tops off bulbs. Brush with oil. Wrap each bulb in heavy-duty foil. Bake at 425° for 30-35 minutes or until softened. Cool for 10-15 minutes. Squeeze softened garlic into a bowl; set aside.
- In a large bowl, combine the egg, bread crumbs, salt and pepper. Crumble beef over mixture and mix well. Divide into 18 portions; flatten. Top each with 1/2 teaspoon softened garlic; form beef mixture around garlic into meatballs. Set remaining garlic aside.
- In a large skillet, cook meatballs in batches until browned on all sides and meat is no longer pink.
- Meanwhile, in a large saucepan, cook bacon over medium heat until crisp. Add onion; cook for 4-6 minutes or until tender. Reduce heat; stir in the vinegar, sugar, pepper and remaining roasted garlic. Cook for 2 minutes or until heated through.
- Drain meatballs; top with chutney and goat cheese. Serve with toasted French bread if desired.


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Colorado casinos rank No. 2 in revenue loss
Colorado casinos took the second-largest revenue hit in the industry in 2008 with a 12.3 percent drop, according to a new report by the American Gaming Association.
Only Illinois suffered a bigger drop with a 20.9 percent decline. The American Gaming Association attributed the states' struggles, in part, to smoking bans that took effect last year.
The Post wrote a story about the steep decline Colorado's casinos were facing last year, and also found that the state ranked No. 2 in terms of revenue decline at that time.
The AGA report, released annually, states that casinos nationwide posted a revenue drop of 4.7 percent in 2008. The report also gives some other interesting tidbits about the gambling industry, such as the fact that racinos (racetracks with slot machines) are booming despite the recession, and how Americans spend nearly as much on candy as they do on casino gambling.
It's worth a flip-through if you are interested in the casino industry.
For 2008, Colorado casinos posted revenue of $715.9 million, down from $816.1 million. They generated $88.4 million in tax revenue for the state, down 23.4 percent from $115.4 million in 2007.


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Heat putting a bear hug on Colorado, as April showers stay away like March snow
"It was so hot today," Johnny Carson would say.
How hot was it?
"I saw two trees fighting over a dog."
Colorado can relate, Mr. Excitement.
It was so hot in Denver today the high temp of 88 toasted the former record of 85 set in 1949. And another record could fall today.
It's been crazy hot awhile, with heat this week that we wouldn't normally feel until August.
The National Weather Service won't release its official May outlook until this weekend, but our chances for April showers are slipping away — in a state with a heart-breaking snowpack of 33 percent of its 30-year average. Nearly all of the Colorado is in a drought
May holds hope. Though the city averages 1.6 inches of snow and 2.4 inches of total precipitation, making it the city's wettest month, followed by 1.8 inches on average in June.
Then again, March is typically our snowiest month with 12.5 inches, and this year we got only a trace.


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MOTO STUFF is the evolution of CRF STUFF. CRF STUFF hit the Moto scene in 2008 with a revolutionary new brake system known as the "BLADE" that quickly became the brake system of choice by top pro teams including MUSCLE MILK Factory HONDA and GEICO Factory Connections Teams. MOTO STUFF now offers the BLADE system along with our line of trick billet fasteners and many other innovative accessories for all MX bikes! "Trick Stuff for the Greatest Dirt Bikes on Earth!" At MOTO STUFF we are dedicated to improving the Fun, Safety and Performance of your bike!
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Co-Authors Deborah Shlian & Linda Reid Talk about their Novel "Dead Air" on the Child Finder Trilogy
Deborah Shlian, MD, MBA practiced medicine in California where she also taught at UCLA. She has published nonfiction articles and books as well as medical mystery/thrillers. Her first two novels, Double Illusion and Wednesday's ChildRabbit in the Moon is an international thriller and has won the Gold Medal for Genre Fiction from the Florida Book Award, the Mystery Book of the Year Silver Medal from ForeWord Magazine, an Indie Excellence Award, a National Best Books Award Finalist from USA Book News and First Prize in the Royal Palm Literary Award from the Florida Writers Association.
Yolanda "Linda" Reid Chassiakos, MD, is a Fellow of the American Academy of Pediatrics, a Fellow of the American College of Physicians, and a Clinical Assistant Professor of Pediatrics at the David Geffen School of Medicine, UCLA. After graduating from and completing her residency in Pediatrics at the Georgetown University School of Medicine, Dr. Reid Chassiakos served as a Lieutenant Commander in the US Navy, and as the Assistant Head of the Ambulatory Branch of Pediatrics at the Naval Hospital, Bethesda and an Assistant Professor of Pediatrics at the Uniformed Services University of the Health Sciences. She then moved to the Department of Health and Human Services Office of Disease Prevention and Health Promotion and served as a medical editor and feature reporter for the evening Eyewitness news at the CBS affiliate in Washington, DC. Dr. Chassiakos joined Lifetime Medical Television as a medical editor, writer, and host of educational programming for healthcare professionals and the public in Los Angeles, and developed and hosted programs and features for media such as the NBC Network Sex, Drugs, and Rock 'n Roll, Lorimar-Telepictures, and You TV.
During her thirteen-year tenure as an Associate Physician Diplomate at UCLA's Arthur Ashe Health Center, Dr. Chassiakos also served as a staff writer for the television series, Family Medical Center. She is currently the Director of the Klotz Student Health Center at California State University, Northridge. Dr. Chassiakos' features and essays have been published in the Washington Post, Baltimore Sun, Woman's Day, Salon.com, the Los Angeles Times, the Los Angeles Daily News, and Tribune International. She has recently co-edited a text on Collaboration Across the Disciplines in Health Care. Dr. Chassiakos has also written a fantasy novel, Where Angels Fear to Tread, for imaginative young adult and adult readers. Dr. Chassiakos and her husband are the proud parents of three teenagers and live in Los Angeles. Read More


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Longitudinal Protocol for Granulomatosis With Polyangiitis (Wegener's) and Microscopic Polyangiitis
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00315393
Recruitment Status : Active, not recruiting
First Posted : April 18, 2006
Last Update Posted : October 10, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Granulomatosis With Polyangiitis Microscopic Polyangiitis Wegener's
GPA and MPA are two autoimmune disorders that cause systemic vasculitis. GPA commonly affects the upper respiratory tract, the lungs, and the kidneys. MPA is marked by kidney inflammation, weight loss, skin lesions, nerve damage, and fever. Many patients with WG or MPA show no visible symptoms of active disease; it is known that underlying subclinical disease activity leads to long-term damage in these patients. Also, because it is difficult to monitor WG and MPA disease activity, it is difficult for clinicians to know when and how to treat these patients. This study will use new scientific methods to identify new biomarkers that can be used to monitor disease activity in GPA and MPA patients. These biomarkers may be used to help direct clinical care for GPA and MPA patients and assist in future drug development.
Study visits will occur monthly for the first year, then every 3 months thereafter for the remainder of the study. Blood and urine collection will occur at every visit. A physical exam and medical and medication history will occur every 3 months; also, participants will be asked to complete several questionnaires to assess disease activity, health status, and tobacco, alcohol, and drug use. Participants may have additional study visits if a disease flare or disease-related complications occur during the study.
|Study Type :
|Estimated Enrollment :
|1200 participants
|Observational Model:
|Time Perspective:
|Official Title:
|Determining Disease Activity Biomarkers in Individuals With Granulomatosis With Polyangiitis (Wegener's) and Microscopic Polyangiitis
|Study Start Date :
|April 2006
|Estimated Primary Completion Date :
|April 2020
|Estimated Study Completion Date :
|April 2020
- Discover biomarkers in GPA/MPA capable of measuring disease activity and response to treatment. [ Time Frame: Study completion ]
- Measure the predictive value of biomarkers for clinical outcome in GPA/MPA [ Time Frame: Study completion. ]
Biospecimen Retention: Samples With DNA
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|Child, Adult, Older Adult
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Inclusion Criteria:
- Diagnosis of GPA or MPA. Widely accepted diagnostic criteria, as opposed to classification criteria or definitions, have not been developed for GPA and MPA.
For diagnosis of GPA, meets at least 2 of the following 5 modified American College of Rheumatology (ACR) criteria:
- Nasal or oral inflammation with oral ulcers or nasal discharge with pus or blood
- Abnormal chest radiograph with nodules, fixed infiltrates, or cavities
- Urinary sediment with microhematuria or red cell casts
- Granulomatous inflammation within the wall of an artery or in the perivascular area on biopsy
- Antineutrophil cytoplasmic antibody (ANCA) positive by enzyme immunoassay for either PR3- or MPO-ANCA
For diagnosis of MPA, meets the Chapel Hill Consensus Conference Definition for MPA:
- Necrotizing vasculitis, with few or no immune deposits, that affects small vessels (i.e., capillaries, venules, arterioles)
- Necrotizing arteritis involving small- and medium-sized arteries may be present
- Necrotizing glomerulonephritis is very common
- Pulmonary capillaritis often occurs
- Parent or guardian willing to provide informed consent, if applicable
Exclusion Criteria:
- Simultaneous diagnoses of both GPA and MPA
- Granulomatosis with polyangiitis (Churg-Strauss)
- Takayasu's arteritis
- Giant cell arteritis
- Polyarteritis nodosa
- Cogan's syndrome
- Behcet's disease
- Sarcoidosis
- Kawasaki disease
- Tuberculosis or any atypical mycobacterial infections
- Deep fungal infections
- Lymphoma, lymphomatoid granulomatosis, or any other type of cancer that mimics anti-neutrophil cytoplasmic antibody-associated vasculitis (AAVs)
- Cryoglobulinemic vasculitis
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Mixed connective tissue disease or any overlapping autoimmune syndrome
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00315393
|United States, Massachusetts
|Boston University School of Medicine
|Boston, Massachusetts, United States, 02118
|United States, Minnesota
|Mayo Clinic
|Rochester, Minnesota, United States, 55905
|United States, Ohio
|Cleveland Clinic Foundation
|Cleveland, Ohio, United States, 44195
|United States, Pennsylvania
|University of Pennsylvania
|Philadelphia, Pennsylvania, United States, 19104
|University of Pittsburgh
|Pittsburgh, Pennsylvania, United States, 15260
|United States, Utah
|University of Utah
|Salt Lake City, Utah, United States, 84112
|Canada, Ontario
|St. Joseph's Healthcare
|Hamilton, Ontario, Canada
|Mount Sinai Hospital
|Toronto, Ontario, Canada, M5T 3L9
|Study Chair:
|Peter A. Merkel, MD, MPH
|University of Pennsylvania
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Peter Merkel, Professor, University of Pennsylvania
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
U54AR057319 ( U.S. NIH Grant/Contract )
|First Posted:
|April 18, 2006 Key Record Dates
|Last Update Posted:
|October 10, 2019
|Last Verified:
|October 2019
Granulomatosis with Polyangiitis
Microscopic Polyangiitis
Systemic Vasculitis
Vascular Diseases
Cardiovascular Diseases
Lung Diseases, Interstitial
Lung Diseases
Respiratory Tract Diseases
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Autoimmune Diseases
Immune System Diseases
Cerebral Small Vessel Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases


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SATA boosts RAID 6 use
High-capacity SATA disks are driving up the use of RAID 6, which has prompted vendors to create new ways of overcoming the performance hit incurred with dual-parity protection.
"SATA drives aren't designed for high performance to begin with," said Brad O'Neill, senior analyst with the Taneja Group. "Wherever users, especially in cost-sensitive smaller organizations or departments and Tier-2 storage in larger organizations, are relying on SATA disks for business operations, it makes more sense to default on the side of better protection in exchange for a minor performance hit."
"The biggest benefit of dual parity is not protection against two simultaneous disk failures, which is a relatively unlikely scenario," said Tom Treadway, chief technology officer (CTO) of the storage software group at Adaptec Inc. "The real protection is against bit failure during rebuild mode."
Users weigh in
"We've had no issues with performance so far," said Andy Tran, senior executive vice president and CTO for Pacific Title and Art Studio, a post-production studio in Hollywood, Calif. Pacific Title is using half a petabyte (PB) of DataDirect Networks' 9550 SATA arrays, which get over the performance hump of calculating two-parity variables by packing extra hardware horsepower into the box in the form of 28 dual-core specialized ASICs surrounding a central cache.
SATA was attractive for storage during film processing because of its high capacity and low cost, Tran said, but the extra protection of RAID 6 is also important. In the course of making a film, Pacific Title creates huge volumes -- up to 30 terabytes (TB) -- out of groups of equally massive LUNs. "In my business we have to make sure that there's no corruption -- any LUN we lose, we lose the entire volume and could lose an entire movie," he said.
Still, Tran said, he has only deployed RAID 6 on one array so far and is working to become more familiar with it before implementing it further. He expects that in the long run he will depend a lot more on RAID 6 but said it's not for everyone -- especially in bigger arrays where devoting two drives per RAID group to parity adds up to higher disk costs quickly.
"I don't think too many [vendors] will provide RAID 6, not as widely as RAID 5," Tran said. "[Users] are also worried about capacity."
New approaches to the RAID 6 performance problem
For users considering RAID 6, some vendors are attempting to ease performance woes through more efficient parity-calculation algorithms, which can reduce the number of disk I/Os required in the process.
In a RAID-5 system, one disk per RAID group is used for calculating parity using an algorithm called exclusive, or in which the processor solves an equation for one value, used to replace missing bits in the event of a drive failure. RAID 6 requires that equation to be solved for two variables, meaning bits in traditional exclusive or processing schemes must be accessed twice. Thus, under the traditional algorithms, solving for two variables with six disks in a RAID group would mean 12 I/Os.
However, vendors offering RAID 6 schemes today, such as Overland Storage Inc., Adaptec and Nexsan Technologies, are instead using the Reed-Solomon algorithm, which allows dual parity to be calculated using one I/O per disk in the RAID group -- so six disks would require a minimum of six I/Os.
Other vendors, most notably Network Appliance Inc. (NetApp), are changing the way storage controllers within their boxes are reading data on disk to reduce RAID 6 I/O loads. For its part, NetApp is using its Write Anywhere File System (WAFL) to place dual-parity data on disk platters in compact stripes so that it can be more easily accessed by the controller during RAID calculation.
Overland has jumped into the RAID 6 space with a feature called DriveAlive, a kind of hot-swapping feature that staves off full-rebuild mode when one of the disk blades in the array chassis is removed for routine maintenance, such as replacing a drive platter. DriveAlive reduces performance issues in rebuilding mode by reducing the cases in which the array goes into rebuild mode at all.
Beyond SATA, RAID 6 may be limited
NetApp said it remains sanguine about the possibilities of RAID 6 as a data protection scheme for Fibre Channel (FC) and serial attached SCSI (SAS) arrays, but whether or not users of more expensive, higher reliability disk drives will ever see a need to stray from single parity is very much in doubt -- something even other disk vendors have said.
"RAID 6 is going to be a checklist item for some customers," said Jerry Hoetger, director of product management for Xyratex. "But I don't really see much interest for it with higher reliability drives, like SAS and Fibre Channel."
More and more users are packing bigger workloads onto less-expensive drives, but there are still cases where performance concerns will win out, according to O'Neill. "Users have to make workload-specific, sometimes application-specific, decisions" about what form of parity protection to use, he said.


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2 Bed Apartment in Heuweloord
R 6 600 Deposit R 6 600
Ofentse Magodielo
2 LET NOW-Midrand
2 Bed Apartment in Heuweloord
R 6 600 Deposit R 6 600
In the heart of Centurion you will find The Junction, one of Gautengs newest and most exciting developments. Your new home is found within a top security estate with 24 hour patrolling guards, play grounds and a modern lifestyle for you and your family.
This luxurious apartment rewards you and your family with:
A large open lounge that leads into your fully equipped modern kitchen.
2 bedrooms with plenty of cupboard space and a full bathroom.
A private patio/balcony that is perfect for a late South African Braai with friends and family.
1 covered carport with plenty of parking for your visitors.
High speed internet fibre straight to your unit at affordable prices.
Prepaid water and electricity meters as well as DSTV plug and play.
The estate is conveniently located and close to top centurion schools, Forest Hill Mall, 10min drive to Midrand , filling stations and easy access onto major transport routes. ( N1, N14, R55 )
We have a show house that is open 7 days a week so make the call and come view your new home today!!
Key Property Features
Email the Agent should you require any further details.
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Experience Centurion West
With many estates dotted around the area, the gated village lifestyle is a popular choice. A sense of community and family abounds, and everyone seems to know each other at the local hang-outs. Situated near the N1 highway between Johannesburg and Pretoria, Centurion West offers a country living ambience not far from the big cities. Sparkling lakes and rolling hills make this area a golfer's paradise. It's a great outdoorsy way of life, with all the comforts of a city life.Find out more about Centurion West
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With its slender proportions, the 3X fits where other fireplaces don't, with venting options for many different types of installation possibilities. Sit back and enjoy a bold, beautiful flame and highly-detailed log set. This small fireplace gives you a lot for your money, including energy efficient warmth and innovations that make it easy to operate.
For Small rooms
Available Sizes: 711 mm
Recommended Size(s) for Small rooms: 28"
Appliance Depth includes entire unit including depth of firebox and extension onto hearth.
BTU: 1st hour output uses high burn efficiency number. BTU will vary depending on the type of fuel used and moisture content of the fuel.
This is a general guide, see your local dealer for help in determining the product that best suits your heating needs based on climate, home efficiency, location of the heater, and air movement in the room.
Actual burn times will vary based on how the appliance is operated, load size, moisture content and type of wood used.
Fuel density and pellet shape will affect hopper capacity.
Weighted Average LHV (Low Heating Value) efficiency.
Heat output will vary depending on the type of fuel used. The flame and ember appearance may vary based on the type of fuel burned and the venting configuration used. Actual product appearance, including flame may differ from image shown. Refer to the owner's manual for complete clearance requirements and specifications. Product specifications and pricing subject to change without notice. For testing and listing information please refer to the owner's/installation manual.
*For select products: Heating capacity to be used as a guide only. See your local dealer for help in determining the product that best suits your heating needs based on climate and home efficiency.
Dimensions in inches. Refer to installation/owner's manual for detailed specifications on installing this product. Hearth & Home Technologies reserves the right to update units periodically. Product installation must adhere strictly to instructions shipped with product.
Why are you contacting us?
Need a Quote
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Have a Question About My Fireplace
A local dealer will contact you, we look forward to helping you.


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It is currently Sat Jan 25, 2020 6:45 pm
Jamie Renton wrote:i was about to contact Charlie, as I've booked Darbucka for the next DJ Relay on 6th May. Part of me feels that I should cancel that now, but another part wonders if we couldn't turn it into some kind of celebration of Charlie ... play the music that he loved, maybe see if we can get a favourite musician of his to play live.
What do you think?
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The Westminster on the Draw building is a mixed-use structure that Westminster is leasing as part of our extended campus initiatives. This structure will allow for 168 additional beds for Westminster upper classmen, as well as the basement level offering 16,000 sq. ft. of event space. The event space will be open to the community October 2012 and will have the capability of seating 500 people. Westminster on the Draw will also house our Division of New Learning and additional classroom space. The street level will be business retail space.
Contact Advancement at (801)832-2730 or email@example.com.