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Tuesday, August 12, 2008
Safin succumbs to neck injury0 comments Posted by Just Tennis at 8:51 PM
WASHINGTON, Aug. 12, 2008 (Reuters) — Marat Safin's U.S. Open preparations suffered a setback when the former world number one was forced to retire from his first round match at the ATP event in Washington with a neck injury on Tuesday.
The Russian sixth seed lost the first set against Italian Fabio Fognini 7-5 and then decided to withdraw from the match.
"I just blocked it and I pulled a muscle," Safin told reporters, adding that he suffered the injury on the second point of the match.
"It was getting worse and worse. I should have stopped earlier. I thought it might get a bit better, but it didn't."
Safin said he would now rest and then go to New York to prepare for the U.S. Open, which begins on Aug 25.
"I need at least four to five days to be able to turn it. I should be OK (for the U.S. Open)," he said. "I can't do much about it. It's a pity but I have to deal with it."
Despite the injury, Safin had surged into a 3-0 lead but after dropping his serve in the fifth game, the double grand slam winner requested an injury timeout.
With his flexibility restricted and his service speed well down, Safin was broken again in a protracted 11th game to give Fognini a 6-5 lead.
Labels: articles, Marat Safin, results
Dinara Safina: The future is now for Safina0 comments Posted by Just Tennis at 8:17 PM
Perhaps we can stop using words like "promising" when it comes to players like Dinara Safina, enjoying now what you would call breakthrough seasons.
The nearly 6-foot, 155-pound Safina, like her up-and-down big brother, men's star Marat Safin, is a punisher of the ball, and has powered her way to a solid 40-13 record so far this year (after two rounds at the ongoing Olympic Games in Beijing), including three of her eight career titles and a current 12-match winning streak. She's rattled off 29 wins in her last 32 matches.
That's pretty hot.
Safina's first title of the year came in Berlin back in May, as she upended Elena Dementieva in an all-Russian clay-court finale. In her next event, Safina soared all the way into the final on the dirt at Roland Garros, only to lose to world No. 1 (at the time) Ana Ivanovic in her first-ever Grand Slam final. On her way to the title match, Safina saved match points in back-to- back matches on her way to upsetting reigning Aussie Open champ and fellow Russian Maria Sharapova in the fourth round and Dementieva in the quarters.
Following the French Open, Safina landed in another final, but was shocked by Thai veteran Tamarine Tanasugarn in the title bout on a grass court in The Netherlands. En route to the final, Safina toppled her compatriot Dementieva, once again, in the semis.
Safina was a disappointing third-round loser (against capable Israeli Shahar Peer) at Wimbledon, but she promptly rebounded in her next tournament by capturing a hardcourt title in Los Angeles, and followed that up by corralling more hardware the following week on a hardcourt in Montreal. All this winning activity in North America produced a U.S. Open Series victory for Safina, which means she will double her prize money in New York. If Safina can win the title in Flushing, she would receive a record $2.5 million payout.
And when it comes to that precious Russian supremacy, Safina is a perfect 6-0, combined, against her fellow Top-10 countrywomen Kuznetsova (No. 3), Sharapova (No. 5) and Dementieva (No. 7) this year.
Safina opened 2008 ranked 15th in the world in singles and has shot up to No. 6, and she's ranked ninth on the planet in doubles, where she's also tallied eight career titles, including a pair this season.
Aside from an Olympic gold medal this week, the skyrocketing Safina has her sights set on the upcoming U.S. Open, where she'll be among the favorites. The powerful Muscovite reached the quarterfinals in New York two years ago, and made it to the fourth round there last year.
When you get right down to it, Safina appears to be headed toward an eventual Grand Slam title, which is something her former world No. 1 and two-time major titlist brother would know about. Safin is a former U.S. (2000) and Aussie Open champ (2005).
Did You Know?: Safina was the doubles titlist (alongside Frenchwoman Nathalie Dechy) at last year's U.S. Open.Source: The Sports Network
Scott Riley, Tennis Editor
Labels: articles, Dinara Safina, photos
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Royal Blue Velvet Booth Seating - Middle Section
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Our royal blue modular booth seating range is a perfect way to configure your seating plan to suit your event space. With 4 separate sections, including middle, end, back and corner you can create a variety of arrangements including back to back, bench or banquette style.
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jon8 needed a new logo design and created a contest on 99designs.
A winner was selected from 182 designs submitted by 72 freelance designers.
We need a design for the company ''PRIKE''.
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1982 Women's Tennis Team
The 1982 women's Tennis Team became the first MWC National Championship Team by capturing the 1982 A.I.A.W. Division III National Title. En route to this title, they won A.I.A.W. state and Regional Championships while achieving a match record of 22-5 (16-0 vs. Division III Teams). Five players were named to the 1982 All-america Team. This team also placed fourth at the first ever NCAA Division III Women's Tennis National Championships.
Inducted October 18, 1996


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Pope Francis announced Sunday that he would travel to Israel, the West Bank and Jordan on May 24-26, his first visit to the Holy Land and one that comes amid a new U.S. push for peace between Israel and the Palestinians.
Francis told thousands gathered in the rain for his weekly Sunday blessing that he was announcing, "in the climate of joy that is typical of the Christmas season," the three-day visit to Amman, Bethlehem and Jerusalem. It is the only trip so far confirmed for 2014 and the second foreign trip of Francis' pontificate, following his 2013 visit to Brazil for World Youth Day.
Francis said the prime aim was to commemorate the 50th anniversary of the historic meeting in Jerusalem between Pope Paul VI and the then-spiritual leader of the world's Orthodox Christians, Ecumenical Patriarch Atengora.
Francis will be joined in Jerusalem by the current ecumenical patriarch, Bartholomew. They will celebrate Mass together at the Church of the Holy Sepulchre, where the faithful believe Jesus was crucified and buried, Francis said.
But the visit will also underscore Francis' close ties to the Jewish community, his outreach to Muslims and the Vatican's longstanding call for peace between Israel and the Palestinians. The announcement was made just as U.S. Secretary of State John Kerry wrapped up three days of talks with Israeli and Palestinian leaders in a new U.S. bid for peace.
In his Christmas address last month, Francis singled out the Holy Land for prayers, saying "Bless the land where you chose to come into the world, and grant a favorable outcome to the peace talks between Israelis and Palestinians," Francis said Dec. 25.
On Sunday, the Palestinian news agency Wafa said President Mahmoud Abbas welcomed the visit and said he hoped it would "contribute to alleviate the suffering of the Palestinian people who aspire for freedom, justice and independence."
In Jerusalem, Israeli Foreign Ministry Yigal Palmor said Israel was excited by the visit. "He's very welcome in Israel and will be greeted as warmly as his predecessors were," he said.
Jordan's Royal Palace said the Amman leg of Francis' visit — on May 24 — would mark a "significant milestone for brotherhood and forgiveness between Muslims and Christians and consolidates the message of peace."
Despite the geopolitical backdrop of the trip, the Catholic Church in the Holy Land insisted that the visit was aimed "mainly at spreading and promoting love, cooperation and peace among all inhabitants of the region."
The Argentine Jesuit, who made forging relations with Jews and Muslims a priority of his tenure as archbishop of Buenos Aires, will be the fourth pope to visit the Holy Land after Paul VI's landmark visit in 1964.
After decades of reluctance by the Vatican to recognize the Jewish state, the Polish-born John Paul II forged formal relations in 1993, following it up with an official visit to Israel in 2000 that included stops at the Holocaust memorial Yad Vashem and at the Western Wall, where he famously left a handwritten plea asking forgiveness for Christian persecution.
The German-born Pope Benedict XVI followed up nine years later with his own visit.
Francis' full itinerary hasn't been released, but the pope's good friend, Rabbi Abraham Skorka, has said he hopes the pope will stop at the Western Wall, the holiest site where Jews can pray in Jerusalem. In a recent interview with The Associated Press, Skorka said he also hoped to pray with Francis in Bethlehem "to show the world it is possible."


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Online Journal of the Virtual Middle East
Daniel Martin
President, American Institute for Yemeni Studies
22 High Pine
Glen Cove, NY 11542
Managing Editor
Vit Sisler
New Media Studies
Institute of Information Studies and Librarianship
Faculty of Arts, Charles University
U Krize 8, Praha 5, 158 00
(+420) 251 080 205 (office)
CyberOrient presents original, peer-reviewed articles and books reviews on the online representation of any aspect of Middle Eastern cultures, Islam, the imagined "Orient" and the use and impact of the internet in the Middle East and Islamic countries.
CyberOrient is exclusively an online journal, begun in late 2006. Since Jan 1, 2011 it is published by the American Anthropological Association in collaboration with the Faculty of Arts of Charles University. Cyberspace transforms the traditional sense of "fieldsite" in anthropology and calls for an approach that transcends disciplinary boundaries. This interdisciplinary journal draws on scholars and students from within and without the field of anthropology.
CyberOrient is published two times a year.
CyberOrient is sponsored and maintained by the American Anthropological Association (AAA) and the Faculty of Arts of Charles University.
An international board of contributing editors assists in the peer review process.
The internet has facilitated the evolution of a "CyberOrient," a virtual Middle East blending the imaginary "Orient" constructed through Western eyes with a wide variety of individual and group self-representation from the region and in diaspora. The old fault line of West vs. East has now been realigned into a virtual maze of crossrepresentation in which alternative and individual imaginaries are potentially available worldwide and instantaneously.
The lag time of print journals presents a problem for study of cyberculture, given that much of this research is conducted online rather than in the library. Issues arising from developments in Internet technology and the ephemeral nature of websites are best approached through an online journal that allows for rapid dissemination of current research and feedback from readers. One of the aims of the journal is to promote interaction with anthropologists and other scholars in foreign countries, as Internet access expands.


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Then check out mine, The Improv Obsession Podcast! I do an almost weekly podcast where guest improvisers come on the show and talk about improv. Past guests have included Joe Wengert, Greg Tuculescu, Eugene Cordero, and Colton Dunn.
Check it out, it's a lot of fun and people keep telling me it's really interesting . So either a lot of liars are trying to mess with me, or it's pretty good.
You can hear it Online or in iTunes.


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Hole 18
Par 4
The Glades greens are unique to any other golf course on the Gold Coast and will ensure a superior putting surface all year round as they consist of a new type of "Creeping bent grass" that offers a true putting surface and is the preference of professionals and amateurs alike.
Playing Tip
Focus your attention on the right half of the fairway. Hit a good drive and the green is reachable in two shots and offers the chance to start with a birdie, or eagle.
Hole Info
- Par 4
- Black: 417m
- White: 395m
- Red: 341m
Hole Reviews
"This is one of my favourite holes; it has a little of everything." — Jim P
"There's nothing like this hole to help you forget your off-course cares." — Mark S


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Line-up of innovative construction equipment
At the 2015 Intermat, the Liebherr Group presents a cross-section of its latest construction machinery technology. The innovative highlights represent Liebherr's product ranges of earthmoving and material handling equipment, special deep foundation machines as well as tower cranes, mobile and crawler cranes and concrete technology. Liebherr not only launches numerous new products for the European market but also presents several world premieres.
Liebherr wins in Paris two Intermat Innovation Awards
On occasion of the international trade press conference " Pré-Intermat " on 22 January 2015 in Paris Liebherr was the only manufacturer who was awarded with two trophies of the Intermat Innovation Award. The Gold Award in the category "Equipment & Components" went to the newly developed crane operator elevator system "LIUP" , a silver trophy in the "Engineering & Systems" category was awarded to the new Liebherr Demolition Control System (LDC) for demolition excavators.
Earthmoving machines for versatile applications
A wide range of Liebherr earthmoving machines is on display in Paris: crawler and wheeled excavators, wheel loaders, crawler tractors and loaders as well as telescopic handlers. One of the highlights is the world premiere of the R 946 crawler excavator with a new Liebherr diesel engine. It features an operating weight of approx. 40 tonnes and is the first crawler excavator from Liebherr to meet stage IV / Tier 4f emission standards.
Cranes for the most diverse range of lifting tasks
Liebherr shows mobile and crawler cranes as well as tower cranes, mobile construction cranes and duty-cycle crawler cranes. And with the simulator for operator training in a virtual reality, Liebherr provides realistic training conditions in order to improve safety and efficiency of lifting operations. Furthermore, the 2015 Intermat is the launch pad for LiUP, the new crane driver elevator for tower cranes.


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Jamaica closes IYA2009 with a successful star party
23 January 2010
In late December the Astronomical Association of Jamaica (AAJ) decided to run a final star party, taking place at the UWI. Mona Campus on a patio above the Physics Department. The main reason for the meet was to introduce members and friends to the fine qualities of Galileoscopes. The AAJ was given 400 units for distribution to High and Intermediate Schools in Jamaica, and this was a practice run for the training of teachers in the assembly, and care of the telescopes.
Participants arrived early at the University, to catch Jupiter at the earliest time after sunset. Two ready-assembled Galileoscopes were brought, along with one in its component parts. Two 3-inch refractors were also present, for comparison.
The telescopes were set on Jupiter and it was explained that observers were looking for Neptune among the moons of Jupiter. Eyepiece expert Bobby Rodriques gave his assessment of the Galileoscopes, concluding that Galileo would have been very happy to have had this instrument. Everyone was pleased with the performance of the Galileoscopes and agreed that the schools will be proud to have them in science programmes.
Thanks to Errol Rickman from the AAJ for providing the information for this update.
Search IYA2009 Updates
National Nodes: 148
Organisational Nodes: 40
Organisational Associates:33
National Websites: 111
Cornerstone Projects: 12
Special Task Groups: 11
Special Projects:16
Official Products:8
Media Partners:22


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Welcome to our Reviews page. From this page, you can access all our reviews for Cameras, Lenses, Audio equipment, and Photography and Videography accessories.
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Jean-Pierre La Forest
Photographer / Videographer at Studio JPIC
Jean-Pierre La Forest is a photographer and videographer based out of Florenceville-Bristol, NB, Canada. JP specializes in commercial and tourism photography and videography, where he helps businesses, artists, and towns to market themselves. He also teaches the art of photography on his YouTube channel and blog. You can reach him on Google+
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- Samsung Gear 360 2017 demo - August 27, 2017
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Mozilla developers are currently debating how to drop support for the much-maligned
<blink> tag.
With Opera moving to Google's new Blink rendering engine, which, despite the name, does not support the blink tag, Mozilla finds itself in the strange position of having the only rendering engine that does in fact parse and display blinking text like it's 1996.
Originally conceived (and implemented) as a drunken joke, blinking text isn't just bad usability — usability guru Jakob Nielsen famously called
<blink> "simply evil" — it can potentially induce seizures. Even if you aren't prone to seizures, blinking text is downright annoying.
But while few may mourn the passing of the
<blink> scourge, really, where would we be without it? Despite never being part of any HTML specification the blink tag managed to take the early web by storm, driven especially by the design prowess of early Geocities homepage creators.
Indeed without
<blink> would there have been a Geocities? And without Geocities would there have been a MySpace? And without MySpace would there have been, well, let's stop there.
Sadly, the end of the blink tag will not mean the end of blinking text on the web. It will ruin this fabulous Twitter Bootstrap theme we've had our eye on, but there are still plenty ways to get text to blink — CSS and JavaScript are both, regrettably, up to the task.
So far there's been little protest about removing
<blink> support from Firefox. There's been some debate as to where or not the CSS 2.1
text-decoration: blink; rule should go with it (yes!), but the tag itself is most likely headed for the dustbin of web history.


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This two hour session will give trustees an outline of the key elements they need to understand and monitor. We will look at a basic set of charity accounts and learn how to unpick the key points. We will cover the essential elements of the Charities SORP: restricted income and expenditure, recognising the costs of generating funds, restricted, designated and general reserves. We will also look at a balance sheet to understand how to interpret and challenge it. Finally we will examine a set of management accounts and learn how to use these to check that all is going to plan in the charity's finances.
Come with those financial questions you have always wanted to ask. Participants are encouraged to bring copies of their charity's accounts with them.
Jacqueline Williams, OnBoard Consultant
5pm registration
5.30pm seminar
7.30pm networking
8.00pm close
£30 excluding VAT. The price below is inclusive of VAT. Please fill in your details below to book your place and pay by card. For any payment queries, please email [email protected]
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If you are not able to attend the event, a substitute can be sent in your place at no extra charge.
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Cancellations made within 7 days of an event are non-refundable. Please note that you are liable for the full amount if you do not attend the event without prior notice.


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wittychris on Family Tree Circles
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Researching Nolan Surname from Co. Kilkenny Ireland
My Grandmother Mary Nolan (maiden name) was born in Co. Kilkenny Ireland..in 1867. died March 1955. buried in St Brigids Coon..5 miles from the Town of Castlecomer. I would like to know the names of her parents also where in Ireland they came from. I would also appreciate names of siblings in her family tree. Thanks
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|Farmington Hills, Mich.
|High School:
College: 2011-12: Played in all 27 games ... Led team in scoring at 16.9 points per game ... Ranked among GLIAC scoring leaders ... Named to All-GLIAC team ... Added 32 assists and 21 steals ... Shot 36.2% from three-point range ... Hit 84.1% of his free throws on the year ... Had 23 double-figure scoring performances ... Scored 20 points or more 10 times, including three games with 29 points each ... Ranked among league leaders in scoring, three-pointers and free throw percentage ... 2010-11: Played in all 32 games ... Named to NCAA Division II Midwest Regional All-Tournament Team ... Member of GLIAC North Division Championship squad ... Averaged 9.2 points per game as a key reserve ... Had 12 double-figure scoring efforts ... Posted a season-high 27 points versus Wayne State in opening round of the NCAA Tournament ... Scored 22 points in the NCAA Division II Regional Semifinals against Drury (Mo.) ... Added 50 assists and 27 steals ... Shot 34% (44-129) from three-point range ... Averaged nearly 20 minutes of action per contest ... 2009-10: Spent the 2009-10 season at Augustana (S.D.), a member of the Northern Sun Intercollegiate Conference (NSIC) ... Appeared in 31 games as Augustana posted a school best 24-7 overall record and reached the NCAA Division II Central Regional Championship Game. The Vikings also recorded a third-place (15-5) finish among 14 teams in the NSIC under head coach Tom Billeter ... Averaged 5.9 points per contest with 183 total points to go with 35 rebounds, 19 assists and 16 steals ... Shot 34.6% (28-81) from the three-point arc and was a 70% (45-64) free throw shooter ... Finished as Augustana's sixth-leading scorer and totaled five double-figure scoring performances, including a season-high 17 points in two of his first three games of the campaign.
High School: A 2009 graduate of Farmington Hills Harrison High School ... Two-year prep starter ... Averaged 28.3 points, 6.3 rebounds and 7.7 assists per game as a prep senior in 2008-09 ... Led the entire state of Michigan in scoring his final year and set two school scoring records, including career scoring and single-game scoring (42) ... Served as team captain ... Helped lead the Hawks to an 11-10 record in his senior season, which marked the best record in school history ... Was a two-time first team all-state selection ... Contributed 19.8 points, 5.3 rebounds, 6.8 assists and 1.7 steals per game as a prep junior ... Also a two-year starter in football ... Recorded 26 catches for 384 yards and three touchdowns as a senior, earning all-area honors.
Personal: Son of Ken and Betty Brown ... Enjoys working out and eating ... Nickname is "Downtown" Kenny Brown ... Born in Pontiac, Mich. ... Sport Management major.


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Molly Sims Interview About Postpartum Body
Did Your Style Change After Becoming a Mom?
Fashion comes and goes, but every woman has her own sense of style, regardless of the trends. That's why I was struck by some comments I heard on the Today show this morning during a segment with Tracy Anderson and Molly Sims. The two women — who both have 4-month-old tots at home — appeared on the show to promote Anderson's new prenatal exercise video.
As you may recall, Anderson got herself into a bit of hot water last month when she suggested that many women use pregnancy as nine months to indulge, rather than take care of their bodies. On the show today she clarified that statement, and Sims talked about the pressure to look good right after having a baby. She said that her new "boho chic" style has received some press coverage but insinuated that it really is just a tactic for covering up the baby weight. Whether it was to hide the baby weight or to accommodate a new work situation, did your style change after pregnancy?


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Bedbugs "Attend" Princeton University
No Place is immune from infestation Say Pest Controllers
In early October, students in a Princeton University dormitory discovered a bedbug infestation in Rockefeller College's Holder Hall and had to be relocated while a pest control firm was called in to eliminate it. Bed bugs were first reported in Holder Hall in September.
"The infestation," said Leonard Douglen, Executive Director of the New Jersey Pest Management Association, "reportedly was the result of a piece of personal furniture brought into the dorm by one of the students and is a good example of how bed bugs can migrate from place to place."
"There is no place where humans live or work that is immune to a bed bug infestation," said Douglen, "and this problem has now spread to all fifty states since they became a significant pest problem as the new century began, invading homes, apartments, dormitories, hotels, and just about anywhere humans lay down to sleep. Bedbugs can detect a body in the room or in one nearby.
Bed bugs get their name from their favorite place to hide out, a mattress, box spring, and bed frame. They can be found in any dark, warm place in a home, apartment, or workplace.
"There has been a dramatic increase" in calls to pest management firms concerning bedbug problems in recent years, Douglen estimates that bedbug-related calls throughout New Jersey has increased 30% to 40% since 2000.
"Bedbugs cannot be exterminated with off-the-shelf pesticides," said Douglen. "Only a professional pest management firm has the knowledge and the EPA-approved pesticides to rid a home or other structure of bedbugs and it usually takes several trips to do it."
Douglen noted that pest management professionals frequently recommend purchasing plastic cases for mattresses that will trap any existing bedbug infestation and keep out a new one. "The plastic must be at least three millimeters thick."
"The good news is that bedbugs do not spread diseases in the same way as mosquitoes or other pest insects. This doesn't mean, however, that being bitten by them doesn't cause a lot of itching and discomfort."
"The problem is attributed to the increase in international travel. People coming into New Jersey and other States from foreign nations bring them in via their luggage. From there, they can spread to anywhere people stay for the night."
Not only do Americans travel abroad in large numbers, but millions of foreigners visit the United States every year.
The quarter-inch long bugs feed primarily on humans at night when they are asleep. Some people have no reactions to the bites, but others experience swelling and redness where they are bitten. While bedbugs do not spread disease, they do leave behind tiny droppings of blood and give off a sickly sweet odor.
Bedbugs can live for more than a year without eating and can withstand a wide range of temperatures from nearly freezing to almost 113 degrees Fahrenheit. This increases the difficulty of eliminating them.
Female bedbugs lay from 200 to 500 eggs, attaching them with a glue-like substance. They hatch in about ten days. Though they do not grow larger than a small seed, they go through five nymph stages, each of which requires a single blood meal before molting. They can suck up to six times their weight and feeding takes from three to ten minutes. Bedbugs produce three to four generations within a year's time.
Founded in 1941, the association's member firms are also members of the National Pest Management Association. The association maintains a website at www.njpma.com where consumers can find listings of member firms
Leonard Douglen @ 800-524-9942
Disseminated by The Caruba Organization
Alan Caruba @ (973) 763-6392


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The organizers have created an impressive program for the two-day event.
The workshop features leading experts from universities and the private sector as well.
A short introduction to the academic focus can be found here.
See above for "Practical information". If you have any questions or queries feel free to contact us.


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Parathyroid and Thymus Transplantation in DiGeorge #931
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00566488
Recruitment Status : Active, not recruiting
First Posted : December 3, 2007
Last Update Posted : May 7, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|DiGeorge Syndrome Hypoparathyroidism Complete DiGeorge Syndrome
|Biological: Thymus/Parathyroid Transplantation
|Phase 1
Detailed: DiGeorge Syndrome is a complex of three problems, 1) cardiac defects, 2) parathyroid deficiency, and 3) absence of the thymus, resulting in profound T-cell deficiency. There is a spectrum of disease in DiGeorge syndrome with respect to all three defects. There is no safe and effective treatment for DiGeorge Syndrome and most patients die by the age of two. For patients with a severe T cell defect, the PI has shown that thymus transplantation is safe and efficacious under other clinical protocols. Subjects with complete typical and atypical DiGeorge syndrome were eligible for this study. Subjects with athymia and profound hypoparathyroidism were eligible for parental parathyroid transplantation in this protocol. DiGeorge syndrome infants, who have successful thymus transplants but have hypoparathyroidism, must go to the clinic for frequent calcium levels and to the hospital for calcium infusions; infants with hypoparathyroidism are at risk for seizures from low calcium. Approximately ½ of infants with profound hypoparathyroidism will develop nephrocalcinosis. Depending on T cell phenotype and function, subjects were given one of two different immunosuppression regimens. Typical complete DiGeorge subjects (with proliferative T cell function < 50,000 cpm) received Thymoglobulin pre-transplantation. Typical complete DiGeorge subjects (with proliferative cell response to PHA > 50,000 cpm) and atypical DiGeorge subjects (with proliferative T cell response to PHA < 75,000 cpm) received Thymoglobulin (pre-transplantation) and cyclosporine (pre-transplantation and post-transplantation). Thymoglobulin was used in part to prevent graft rejection and also to deplete any T cells in the donor parathyroid. Cyclosporine was used to deplete activated T cells in the recipient. For all subjects, acetaminophen, diphenhydramine, and methylprednisolone were given concurrently with the rabbit anti-human thymocyte globulin. The thymus was cultured in standard medium for 10-21 days to deplete mature thymocytes which could cause GVHD. In the operating room, thymus tissue was placed in the quadriceps muscle in one or both legs. The parathyroid donation was preferably done at the same time as the thymus transplantation. Parathyroid tissue was placed in the quadriceps muscle in only one leg, using the same incision as the thymus transplantation. Depending on post-transplant immune status, subjects may have received cyclosporine and steroids.
For 3 months after thymus transplantation, T cells were monitored by flow cytometry approximately every 2-4 weeks. Alternatively, absolute lymphocyte count was used as the maximum possible T cell number. At 2-3 months post-transplant, the subject may have had a thymus allograft biopsy, done under general anesthesia in the operating room. The biopsy was approximately 4 pea-sized (3x3mm) portions of muscle tissue where the thymus transplant had been inserted. Using immunohistochemistry, the biopsy determined thymopoiesis and any graft rejection. The parathyroid was not biopsied because it is very small; doing a biopsy could remove all of the parathyroid tissue. A research skin biopsy (at site of skin incision at the time of transplantation) was done to determine whether T cells were present pre-transplantation. A skin biopsy was also done at the time of thymus graft biopsy to look for clonal T cell populations. For all subjects who developed T cells, post-transplantation pneumocystis prophylaxis was used for approximately 1 year and IV immunoglobulin for approximately 2 years.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|25 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Parathyroid and Thymus Transplantation in DiGeorge Syndrome, #931
|Study Start Date :
|January 2005
|Actual Primary Completion Date :
|August 2007
|Estimated Study Completion Date :
|June 2027
Experimental: Thymus and Parathyroid transplantation
Thymus/Parathyroid Transplantation in Complete DiGeorge Syndrome Infants
Biological: Thymus/Parathyroid Transplantation
Thymus tissue, thymus donor, mother of thymus donor, & parental parathyroid donor screened for transplant safety. Depending on T cell phenotype & function, subjects were given 1 of 2 immunosuppression regimes. All received rabbit anti thymocyte globulin pretransplantation. Others also received cyclosporine pre & post-transplantation. The thymus dose was over 0.2 grams/kg recipient weight. Thymus transplant occurred in operating room; thymic slices were placed in quadriceps. Parathyroid harvest was done under general anesthesia. One parathyroid gland was minced and placed in quadriceps muscle. There was no dose in mg. An open biopsy of thymus allograft was done 2-3 months post-transplant. Biopsy tissue was examined by immunohistochemistry to evaluate for thymopoiesis & graft rejection.
Other Name: IND 9836, Thymus Tissue
- Efficacy parameter: use of calcium/calcitriol at 1 year post-transplantation. [ Time Frame: 1 year after thymus transplantation ]Subjects wtih complete DiGeorge anomaly who have received thymus and parathyroid transplants and survived to one year
- Efficacy parameters: ionized calcium [ Time Frame: 10-14 months after thymus transplantation ]Ionized calcium (normal values are 1.2 - 1.37 mmol/L)
- Efficacy parameters: CD3 count [ Time Frame: 10-14 months after thymus transplantation ]CD3 count/mm3
- Efficacy parameters: CD4 count [ Time Frame: 10-14 months after thymus transplantation ]CD4 count/mm3
- Efficacy parameters: CD8 count [ Time Frame: 10-14 months after thymus transplantation ]CD8 count/mm3
- Efficacy parameters: naive CD4 count [ Time Frame: 10-14 months after thymus transplantation ]naive CD4 count/mm3
- Efficacy parameters: naive CD8 count [ Time Frame: 10-14 months after thymus transplantation ]naive CD8 count/mm3
- Efficacy parameters: proliferative response to phytohemagglutinin [ Time Frame: approximately 1 year after thymus transplantation (8.9 to 17.8 months after transplantation) ]proliferative response to phytohemagglutinin in counts per minute
- Efficacy parameters: proliferative response to tetanus toxoid [ Time Frame: approximately 1 year after thymus transplantation (8.9 to 17.8 months after transplantation) ]proliferative response to tetanus toxoid in counts per minute
- Efficacy parameters: spectra typing at 1 year post transplantation [ Time Frame: approximately 1 year after thymus transplantation (12.1 to 18.0 months after transplantation) ]Variability of CD4 T cell receptor beta repertoire as assessed by the Kullback-Leibler divergence (DKL)
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|up to 24 Months (Child)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Transplant Inclusion:
- Complete DiGeorge syndrome (typical or atypical) - may have DiGeorge as part of 22q11 hemizygosity, CHARGE association, or diabetic embryopathy or they may have no associated syndromes.
Must have 1 of following:
- Circulating CD3+ T cells < 50/mm3; or
- Circulating CD3+ T cells that also positive for CD45RA and CD62L must be <50/mm3 or must be < 5% of total T cells.
- Must be <24 months old
Laboratory studies must be done w/in 1 month of treatment:
- Thyroid studies - if abnormal must be on therapy, if recommended by endocrinology:
- PT and PTT must be <2x upper limits of normal (ULN)
- Absolute neutrophil count must be >500/mm3
- Platelet count must be >50,000/mm3
- AST and ALT must be <5x ULN
- Creatinine must be <1.5 mg/dl
- Parents must agree to have infant stay in Durham until thymus biopsy is done 2-3 months post-treatment.
- Typical subjects must not have a rash with T cells on biopsy nor lymphadenopathy.
- Atypical subjects have rash with T cells on biopsy; may have lymphadenopathy.
- PHA proliferative responses must be tested 2x • Atypical: PHA response must be <75,000cpm on 2 tests; test can be done while on immunosuppression.
Additional Criteria for Parathyroid Treatment Inclusion
- Hypoparathyroidism
- At least 1 parent must agree to be parathyroid donor
- Must require calcium supplementation to maintain ionized calcium >1.0 mmol/L. Alternatively, intact PTH must be <lower limit of normal when ionized calcium is <1.2 mmol/L. (Intact PTH measured 2x pre-treatment.)
DiGeorge Treatment Exclusion:
- Heart surgery conducted <4 weeks pre-treatment
- Heart surgery anticipated w/in 3 months of treatment
- Rejection by surgeon or anesthesiologist as surgical candidate
- Lack of sufficient muscle tissue to accept 0.2gms/kg treatment
- Prior attempts at immune reconstitution, such as bone marrow treatment or previous thymus treatment
- Doesn't commit to remaining at Duke until thymus allograft biopsy
Parathyroid Donor Inclusion:
- Serum calcium in normal range
- Normal parathyroid hormone function
- HLA typing must be consistent with parentage.
- Must not be on anticoagulation or can come off
- Parent chosen for donation will be the 1 sharing most HLA alleles with thymus donor
- HLA-DR matching preferred over HLA class I matching. If there no HLA matching at all, then either parent will be acceptable if meets other criteria.
- Negative for EBV; CMV; HIV-1; Syphilis; West Nile virus; Hepatitis B; Hepatitis C; pregnancy; & evidence of head/neck infection
- Fiberoptic nasolaryngoscopy shows vocal cords functioning normally.
- Normal thyroid function
- No history of cancer
- The infant-recipient has 2 living involved parents.
Parathyroid Donor Exclusion:
- Infant recipient doesn't have 2 living involved parents
- Animal tissue/organ recipient
- Syphilis
- West Nile virus
- Hepatitis B
- Hepatitis C
- Pregnant
- Evidence of head/neck infection
- Vocal cords not functioning normally.
- Thyroid abnormalities
- Hyperparathyroidism
- History of cancer
- Mad cow disease (positive)
- SARS(and exposure)
- Smallpox exposure
Biological Mother of DiGeorge Subjects Inclusions:
Mother must be competent to consent or assent to study participation and willing to provide blood sample. No other inclusion/exclusion.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00566488
|United States, North Carolina
|Duke University Medical Center
|Durham, North Carolina, United States, 27705
|Principal Investigator:
|M. Louise Markert, MD, PhD
|Duke University Medical Center, Pediatrics, Allergy & Immunology
Publications of Results:
Other Publications:
|Responsible Party:
|M. Louise Markert, Professor of Pediatrics, Duke University
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
R01AI047040 ( U.S. NIH Grant/Contract )
5K12HD043494-09 ( U.S. NIH Grant/Contract )
R01AI054843 ( U.S. NIH Grant/Contract )
FDA-FD-R-002606 ( Other Grant/Funding Number: FDA )
2R01AI047040-11A2 ( U.S. NIH Grant/Contract )
R56 Bridge R01AI4704011A1 ( Other Grant/Funding Number: [NIH American Recovery and Reinvestment Act (ARRA) of 2009] )
3R56AI047040-11A1S1 ( U.S. NIH Grant/Contract )
|First Posted:
|December 3, 2007 Key Record Dates
|Last Update Posted:
|May 7, 2019
|Last Verified:
|May 2019
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
Thymus Transplantation
Parathyroid Transplantation
DiGeorge Syndrome
Calcium-Regulating Hormones and Agents
DiGeorge Syndrome
Marfan Syndrome
Pathologic Processes
Parathyroid Diseases
Endocrine System Diseases
22q11 Deletion Syndrome
Craniofacial Abnormalities
Musculoskeletal Abnormalities
Musculoskeletal Diseases
Heart Defects, Congenital
Cardiovascular Abnormalities
Cardiovascular Diseases
Heart Diseases
Lymphatic Abnormalities
Lymphatic Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn
Bone Diseases, Developmental
Bone Diseases
Connective Tissue Diseases


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A woman who worked in the IRS Cincinnati office at the center of controversy over targeting of conservative groups says she doubts that the blame resides with front-line employees, as the agency has claimed.
A former manager at the IRS Cincinnati office at the center of the controversy over the targeting of conservative political organizations seeking tax-exempt status tells NBC News she doesn't think low-level employees acted on their own in flagging them for further scrutiny.
But she also said that in her time at the IRS she has never known politics or partisan motivations to play any role in the office's work, and doesn't think it did in this case.
Bonnie Esrig, a 38-year IRS veteran, worked as an area manager in the Determinations Unit of the IRS' Exempt Organizations department in 2011 and 2012. According to a federal audit and IRS Congressional testimony, some employees in the unit used inappropriate selection criteria to flag the applications of Tea Party and other conservative organizations for further scrutiny, according to an audit by the Treasury Inspector General for Tax Administration. (Esrig worked on tax-exemption status issues in the IRS office, but for other types of organizations, such as charter schools – not on the political advocacy groups cases at the center of the controversy. She retired from the IRS in January.)
The audit released last week by the Department of the Treasury's Inspector General for Tax Administration found that IRS employees in that unit "targeted" conservative political advocacy organizations for additional review based on keywords in their organizations' names, such as "Tea Party."
Esrig said that recent media headlines reporting that "rogue" agents were responsible and questioning whether the Obama Administration had played a role, surprised her, given her first-hand knowledge of the unit and its work.
"Those were things that were not consistent with my knowledge of the way the organization works," Esrig said.
Esrig said she doesn't believe that a few employees in the Cincinnati office made the decisions to use the inappropriate selection criteria – as the IRS has claimed to Congress and as the Treasury Inspector General reported in its audit.
According to a congressional source, the IRS reported in a briefing to Congress that two "rogue" employees were responsible for the use of the criteria.
But Esrig said that doesn't make sense based on her experience.
"The idea of two rogue employees," Esrig said, "is inconsistent with the kinds of checks and balances that are inherent in the way the organization is set up."
Nor does she believe the IRS assertion in its response to the Inspector General's audit that the use of such inappropriate selection criteria were "mistakes" and that "front-line career employees … made the decisions."
"Front-line employees (at the Cincinnati office) do not make key decisions about policy and how work is processed," Esrig told us. "Work is reviewed by the managers. The employees don't operate autonomously where there is no review. The managers review.
"I think that even if an employee were to veer off in a separate direction briefly, I would be very surprised if anyone could sustain that before management became involved."
But Esrig agreed with a second claim the IRS has been making: that the employees using the inappropriate criteria "acted out of a desire for efficiency and not out of any political or partisan viewpoint."
She said that she never saw any political or partisan behavior in her time in that office and that she does not believe that there was any political motivation behind the use of the inappropriate selection criteria.
"I don't believe that it was in any way political," she said.
Likewise, she said, she never saw any hint of partisanship during her nearly four decades with the IRS.
The Inspector General's audit stated that, when it asked various IRS personnel, from Acting Commissioner Steven Miller to employees in the Exempt Organizations Determinations Unit, whether there had been any outside influence in the selection of the criteria, "All of these officials stated that the criteria were not influenced by any individual or organization outside the IRS."
Esrig told NBC News that she agrees that the IRS was not acting on any outside direction, presidential or otherwise.
"The way the IRS operates," Esrig said, "over my years of experience in various roles, including working in Washington, D.C, I have never seen anything come down where the administration was directing the IRS to handle something in one way versus another way."
Esrig told NBC News she thought Miller's testimony to a congressional committee last week that employees were using keywords as a shortcut to select cases more efficiently -- and not for political reasons -- was entirely plausible.
"I absolutely believe that cases could be grouped for reasons that had absolutely nothing to do with partisan concerns," she said. "I don't think that there is anything political about the grouping of cases."
The IRS Exempt Organizations Determinations Unit is located on the fourth floor of the Federal Building at 550 Main St. in downtown Cincinnati. It is the location which receives, reviews and processes all applications for tax-exempt status, and from which letters of acceptance or denial originate.
The IRS has reported to Congress that approximately 140 employees – most of them in Cincinnati -- have been doing the work on political groups cases, out of the IRS overall staff of 90,000.
Related story
IRS official to invoke Fifth Amendment at hearing
In recent years, those employees handled an increase in the number of political advocacy organizations engaging in both social welfare and political activities applying for tax-exempt status under section 501(c)(4) of the Internal Revenue Code.
NBC News has attempted to contact other IRS employees -- present and former, in Cincinnati and elsewhere -- who were involved with the tax-exempt determinations during the period when the targeting occurred, but those employees either have declined to comment or have not responded to requests.
Esrig said she has not talked to any of her former colleagues about the controversy, and is speaking only based on her experience in that office.
"I believe that the employees were trying to do the best job they could with the guidance they were given," she said.
Lisa Myers is NBC News' senior investigative correspondent; Rich Gardella is an investigative producer for NBC News.
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A Florida man is facing a battery charge after he beat up a woman who wanted to change the channel on a television, police said.
Roosevelt Franklin, 52, was charged with domestic felony battery and resisting arrest without violence following his arrest late Sunday night, according to a Gainesville Police report.
Franklin was being held on $50,000 bond Tuesday and it was unknown whether he has an attorney.
VIDEO: Duck Calling Competition Heats Up
According to the report, Franklin got into verbal altercation that turned into a physical fight with the woman over flipping channels on the TV. The two have been living together for the past 15-20 years, the report said.
At one point, Franklin "became angry with her, grabbed her hair from behind and smashed her head against the living room wall at least three times causing contusions to both her right eye and forehead," the report said.
Man Found Burning Random Items a Sex Offender: Police
When officers arrived, they found the victim with the head injuries as well as a bleeding cut on her left shin, though the woman was unable to say how she received the cut, the report said.
Franklin said the altercation never turned physical and denied causing the woman's injuries, saying they were likely from the woman falling earlier because she was heavily intoxicated, the report said.
Man Calls 911 to Report Kidnapping After Girlfriend Moves Out
Franklin admitted that the woman and a witness had been disturbing him as he was trying to watch television, the report said. When officers tried to arrest Franklin, he resisted their efforts to handcuff him, but they were eventually able to take him into custody, the report said.
The victim told officers Franklin has battered her multiple times in the past, some of which she didn't report, the report said. Records showed at least five prior convictions for battery related offenses for Franklin, police said.
More Local Stories:


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DarkSynergy needed a new stationery design and created a contest on 99designs.
A winner was selected from 26 designs submitted by 15 freelance designers.
Techgage is an awarded tech website that has been around for a year and a half. We are needing a redesigned business card and from what we have read, this is the place to go.
Desired Color Scheme:
Techgage yellow incorporated, readable font
We want a conventional business card but also want it to stand out. If possible, I would like to get them printed on cards with the top right corner curved. The text has obviously got to be readable and I would like to have a semi transparent Techgage logo on the back of the card. Included is a link to our logo. Anyone interested, please email me, or PM me, and I can provide you with a hard copy of the logo itself.
Thank you and good luck.
Here are the lossless files for those that will need them.