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Prof. Dr. Edward Y. Chang received his B.S. degree from Materials Science and Engineering, National Tsing Hua University, Hsinchu, Taiwan in 1977, and his Ph.D. degree from Materials Science and Engineering, University of Minnesota Minneapolis, MN in 1985 Dr. Chang was with Unisys Corporation GaAs Component Group, Eagan, MN, 1985 to 1988 and Comsat Labs Microelectronic Group from 1988 to 1992. He worked on the GaAs MMIC programs on both groups. He joined National Chiao Tung University (NCTU), Hsinchu, Taiwan, in 1992. In 1994, he helped set up the first GaAs MMIC production line in Taiwan, and become president of Hexawave Inc., Hsinchu, Taiwan, in 1995. He returned to the teaching position at NCTU in 1999. Dr. Chang is currently the Dean of Research and Development and professor of the Department of Materials Science and Engineering and Dept of Elecrical Engineering at NCTU. He is also the director of Diamond Lab and the director of NCTU-TSMC research center.
Process and packaging technologies of III-V high-speed and high-frequency electronic devices GaN epitaxy and device technologies III-V(GaN, GaAs, InAs)/Ge/Si heterogeneous materials Integration.
Anita Sagadevan Ethiraj has completed her PhD from Department of Physics, University of Pune, India in 2006. She was a visiting scientist and BK21 postdoctoral researcher for the year 2006-2008 in POSTECH and SKKU, South Korea. She also worked on US defense sponsored project from 2010-2013 at North Carolina, USA. Dr. Anita is presently working as an Associate Professor in the Physics Department, VIT-AP University, India. Her research area of interest includes core-shell nanoparticles, quantum dots in diodes and LED's, thin film technology, photovoltaics, green chemistry, Graphene/metal oxide based nanocomposites for environmental and energy applications. She has delivered several Invited talks in National and International Conferences, served as Convenor, National Advisor Committee member, Technical Committee Member and session chairs, holds membership in many professional organizations, reviewer for Elsevier & Springer Publisher journals and has numerous peer reviewed impact factor papers to her credit.
ELSAYED AHMED ELNASHAR, Full-Professor of textiles Apparel, Kaferelsheikh University, Egypt. Born in 19/8/1965. Have Ph.D 2000, Msc.1995, Bsc.1989, Helwan University. Diploma 1985 advanced industrial textiles institute. He holds several academic administrative positions: Dean, Vice Dean, Head of Department, He has many textiles patents, Member of international scientific committees. Development of Faculties of Education, commissioned of Supreme Council of Egyptian Universities. Has design books published in Germany. Has published over 175 scientific Articles. Editorial board member & Reviewer for more 60 journal Founder and editor two scientific journals. And Smartex Conference Egypt. Member of the editorial board of several international journals and conferences, He has made many scientific agreements with European &Africa universities
LASER-JET TECHNOLOGY ON WEAVING MACHINE -Antimicrobial Throw Volume Porosity -Membrane Technology for Filtrations: Water/Wastewater, Air Conditions, Cement Factory, Gas And Petroleum - Solar textiles (SOLATEX) of composite fabrics structures as alternative energy. - Functional Nano biodegradable - Computational Mathematics - Fluid Mechanics - Composites fabrics structures -Automotive of - Composites fabrics structures so airbags systems - Energy Effective Method of Modeling and Manufacturing - MULTISTITCHED 3D NANO COMPOSITE - Composites made of multilayered - Nanoart, and Nanotechnology in textiles and apparel branch. -improved simulating fitting cloth model of apparel surfaces. -the influence of the bulky woven fabrics on thermal insulation properties of clothing. -Design curtains fringe and passementerie strips of lace design elements in current high fashion. -Representative volume of design elements and mathematical of pile and velvets woven fabrics. -Volume porosity and permeability in fabrics. -Porosity and permeability in multi-layer woven fabrics. -The influence of weave and the method of stitching on some mechanical properties of woven double fabrics. -Effect the design and materials of eyes swathe dressing and diapers clothes for infant's incubator. -The effective of some difference between the methods of the embroidery on some performance properties to the clothing product. -The effective of some difference structures on quality of pilling cloth -Effect of some different care systems process on dyeing cotton fabrics -Effect of some fabric constructional on comfort and the aesthetic properties for kid clothes -Using remote sensing technology for monitoring of chemical pollutions and bioremediation of chemical -contaminated water -Automatic pattern unwrapping technology -Energy saving and improving stretch properties -Spring-mass based modeling for fabrics physics to 3D garment -Cloth design and application -Clothing simulation and animation -Body shape analysis of Hispanic women Tires and rubber industry
Dr. hab. eng. Miros?aw Kwiatkowski in 2004 obtained Ph.D. degree from the Faculty of Energy and Fuels at the AGH University of Science and Technology in Kraków (Poland), and in 2018 D.Sc. degree from the Faculty of Chemistry at the Wroc?aw University of Technology (Poland) in the discipline: chemical technology. His published work includes more than 45 papers in reputable international journals and 90 conference proceedings. Dr. hab. eng. Miros?aw Kwiatkowski is the editor in chief of The International Journal of System Modeling and Simulation (United Arab Emirates), an associate editor of Micro & Nano Letters Journal (United Kingdom) and a member of the many editorial board of internationals journals as well as a member of the organizing and scientific committees many international conferences in Europe, Asia and United States of America. Dr. Miros?aw Kwiatkowski is also a regular reviewer in a most reputable scientific journals.
Dr. Osman Adiguzel graduated from Department of Physics, Ankara University, Turkey in 1974 and received PhD- degree from Dicle University, Diyarbakir-Turkey in Solid State Physics. He studied at Surrey University, Guildford, UK, as a post doctoral research scientist in 1986-1987, and his studies focused on shape memory alloys. He worked as research assistant, 1975-80, at Dicle University, Diyarbakir, Turkey. He shifted to Firat University in 1980, and became professor in 1996, and He has already been working as professor. He published over 50 papers in international and national journals; He joined over 100 conferences and symposia in international and national level as participant, invited speaker or keynote speaker with contributions of oral or poster. He served the program chair or conference chair/co-chair in some of these activities. In particular, he joined in last three years (2014 - 2016) over 20 conferences as Keynote Speaker and Conference Co-Chair organized by South Asian Institute of Science and Engineering (SAISE), and other institutes and companies. He joined as Keynote Speaker and Conference Co-Chair at 6 conferences held in first half of 2017. Dr. Adiguzel served his directorate of Graduate School of Natural and Applied Sciences, Firat University in 1999-2004. He supervised 5 PhD- theses and 3 M.Sc theses. He is also Technical committee member of many conferences. He received a certificate which is being awarded to him and his experimental group in recognition of significant contribution of 2 patterns to the Powder Diffraction File – Release 2000. The ICDD (International Centre for Diffraction Data) also appreciates cooperation of his group and interest in Powder Diffraction File.
Shape memory effect and displacive phase transformations in shape memory alloys and other alloys, molecular dynamics simulations, alloy modeling, electron microscopy, x-ray diffraction and crystallography.


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(!) Since support from Microsoft will end on January 14 2020, Windows 7 user might not be able to use MISUMI website effectively. Please consider to update your system as 'MISUMI Website system requirement'. เนื่องจาก Microsoft จะหยุดให้การสนับสนุนระบบปฏิบัติการ Windows 7 ตั้งแต่วันที่ 14 มกราคม 2563 และอาจส่งผลให้ผู้ใช้ระบบปฏิบัติการ Windows 7 ไม่สามารถใช้งานเว็บไซต์มิซูมิได้อย่างสมบูรณ์ กรุณาอัพเดทระบบและบราวเซอร์ตามเงื่อนไขระบบที่รองรับมิซูมิเว็บไซต์
A wide variety of standard and configurable components for factory automation engineers in industries such as automotive, semiconductor, packaging, medical and many more.
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Dolly cart with wheels that can be folded away when handle is folded.
· When the handle is folded, the wheels can also be folded away under the loading platform. Handle and wheels lock in place when folded, preventing accidental unfolding.
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Vulcan wooden frame
Four legs chair with upholstered seat and back.
The flexibility of the back makes it very comfortable and the design of the back makes it unique.
Back cover in nylon available in various colours.
Beech solid legs connected to metal frame
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Ideal for: restaurant, meeting tables, interior design, kitchen furniture, schools, cafes, bars.
Optional: Oak, wengé, birch finish for the frame.


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Matthew Miller, PhD
Assistant Professor, Department of Biochemistry and Biomedical Sciences
(905) 525-9140 x 22387
McMaster University
Research Interests
Seasonal influenza virus epidemics remain a major source of global morbidity and mortality. The prevention of influenza is especially challenging because the virus quickly develops "resistance" to seasonal vaccines by virtue of its high mutation rate. The Miller Laboratory is studying strategies to prevent vaccine resistance by targeting conserved features of the virus that do not tolerate mutation.
Recent Publications
Structural–Functional Studies of Burkholderia cenocepacia d-Glycero-β-d-manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties (2013)


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|On backorder
|Delivery time:
|Approx. 3 weeks
A wonderfully sized, exquisitely-balanced, stemmed wine glass that is equally at home with red or white, with elegant proportions but a robust constitution. Sand-etched with your surname and coat-of-arms. The ideal gift for anyone with an Irish branch on their family tree.
Please allow up to 3 weeks for these custom glassware sets.


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Does your pet need an energy boost? Is she/he on recovery? Not having the right nutrition? Is he/she prone to get mild infections? Do you want to take a break from medication and try a natural alternative? Or maybe you just want to make sure that you're providing the best care and all necessary nutrients. No matter the reason, here is a good display of things you can try.
NutriPlus gel 120gNutri-Plus Gel® is a great source of energy. Containing multi-vitamins, trace elements and easily digestible components especially formulated to support your pet during intense physical effort (working dogs) and special physiological situations (pregnant and lactating bitches/queens), as well as aiding in the recovery of pets with decreased appetites.
Product benefits :
A high source of energy containing multi-vitamins and trace elements.
Easy to use gel formula
Highly palatable
Nutribound for cats 3x150mlNutribound® is a highly palatable, liquid, complementary feed which helps to stimulates eating and drinking in cats, and has been formulated to help pets who need encouragement to eat and drink, be they recovering from surgery, illness or for those who are experiencing a general lack of interest in food or water.
Product features :
Liquid form – easy to administer into food or water, or on its own
Highly palatable
Essential amino acids provide vital nutrition to the malnourished pets.
Nutribound for dogs 3x150mlNutribound® is a highly palatable, liquid, complementary feed which helps to stimulates eating and drinking in dogs, and has been formulated to help pets who need encouragement to eat and drink, be they recovering from surgery, illness or for those who are experiencing a general lack of interest in food or water.
Product features :
Liquid form – easy to administer into food or water, or on its own
Highly palatable
Essential amino acids provide vital nutrition to the malnourished pets.
Revital Aid for cats and dogsRevitalAid is a comprehensive, all-in-one multivitamin and mineral supplement.
RevitalAid is a dietary supplement containing thiamine HCL, riboflavin, niacin, vitamin B12, vitamin B6, biotin, folic acid, vitamin C, pantothenic acid, iron, iodine, potassium, choline, selenium, copper sulphate pentahydrate, manganese sulphate, zinc, vitamin A, vitamin D3 and vitamin E for dogs and cats.
It is supplied in 250ml bottles of oral feed.
Pet-Tabs MultivitaminPet Tabs are a dietary supplement for dogs which help correct nutritional deficiencies caused by poor diet or appetite loss.
Pet Tabs are scored tablets that contains at least 18 essential vitamins and minerals as a dietary supplement for dogs.
The Palatable meat-flavored base has special taste appeal and is low in calories.
Available in a pot of 60 or 180 tablets.
VIUSID Pets OralViusid Pets is a nutritional preparation made of antioxidants, vitamins, trace mineral, and an element extracted from liquorice root (glycyrrhizinic acid) that has antiviral properties. It is specially designed to boost your pet's immune system and is perfect to prevent immunodeficiency.
It is well known that the supply of nutrients with antioxidant character is essential to ensure a good functioning of the immune system.
It is available in 150ml bottle.
ACE High Multivitamin/MineralsACE High Multivitamin/Mineral Supplement is dietary supplement for birds, reptiles and other small animals.
ACE High Multivitamin/Mineral Supplement is dietary supplement enhanced with vitamins A, C and E for birds, reptiles and other small animals.
It is available in 50g packs of powder.
YumPuppyNutritional support for expectant mums and growing puppies.
Just welcomed a new puppy home? Playing birth partner to a canine mum-to-be? Help them along with YUM Puppy, a natural supplement that's specifically developed to support new mums and their growing pups.
Supports health, growth and development
Promotes healthy digestion
Supports natural immunity
Aids brain and eye development
Provides critical nutrients for mums-to-be
Onychotin tabletsOnychotin encourages healthy nail growth, strengthens nails and helps to smooth out brittle ridges that can act as weakness lines leading to nail fractures.
Onychotin™ contains 2.5mg of biotin to strengthen weak and brittle nails.
Improvement in nail condition will typically take 3-6 months.
A variety of factors can lead to brittle nails including:
Repeated trauma when the nail is chewed.
Repeated wetting of the nail as will occur with constant licking.
Melacutin tabletsHigh concentrate Melatonin supplement for dogs. Can be used as a sleep aid in restless animals and for breeds suffering with seasonal hair loss.
Plush coated breeds such as the Chow and Pomeranian often benefit from melatonin supplementation which can help improve hair coat quality. Breeds such as the Boxer and Airedale that suffer from seasonal hair loss or thinning of hair on their flanks and breeds that have unusually heavy seasonal moults may find melatonin tablets advantageous.
Zinacutin tabletsZinc is important in metabolically active tissues such as the intestine, immune system and the skin.
Northern breeds such as the Husky, Malamute and Samoyed may benefit from additional supplementation. Rapidly growing dogs may also on occasions require extra zinc.
Dogs with poor liver or gastro-intestinal function often benefit from zinc.
The incorporation of zinc into a palatable base decreases the risk of gastro-intestinal upsets which can be seen with other highly concentrated supplements.
Cobalaplex for dogs&catsSupporting normal serum cobalamin and folate levels in dogs and cats.
Cobalaplex has been designed to help support normal serum cobalamin (vitamin B12) and folate (vitamin B9) levels in dogs and cats, helping them to enjoy a happy, healthy life.
Cobalaplex is presented as sprinkle capsules that can either be given whole or opened and the contents sprinkled onto food. The artificial chicken flavour ensures excellent palatability.
Available in a pack containing 60 capsules.
Show More


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4/11/2019 Brisbane summer carnival heats up
The rich Queensland summer carnival begins to ramp up when several of the likely stars make their public reappearance at the Doomben trials.
The summer carnival starts with the Group Three George Moore Stakes at Doomben on November 23 and ends with the Sunshine Coast Cup in late January.
The highlight will be the $10 million Magic Millions race day on January 11 at the Gold Coast.
Premier Brisbane trainer Tony Gollan has dominated the summer carnival for nearly a decade and will trial some of his stars on Monday.
Smart mare Outback Barbie will head the team into the summer sprints and she will run in the second heat over 1000m.
Outback Barbie will have the choice of several races as a grand final on Magic Millions day in January including the Fillies and Mares race and the Cup.
Darling Downs trainer Steve Tregea has nominated his top sprinter Niccanova after the Toowoomba trials were abandoned last week.
Gollan's multiple stakes winner I'm A Rippa will be opposed by Desleigh Forster-trained Chapter And Verse in the first heat of the day.
"I'm A Rippa will tackle the summer sprints in Brisbane and head to the Magic Millions day," Gollan said.
Chapter And Verse won the $1 milion Magic Millions QTIS race this year and will either go there again or head to the Magic Millions Cup.
"I am pleased with the way he has come back and the trial is the start," Forster said.
Gollan will also have Silvera, another stakes winner, in the same heat and the gelding is headed to the 1600m feature races in coming months.
The Chris Munce-trained Boomsara, who won the Magic Millions Guineas this year, is also on the Magic Millions trail again and will run in a shorter heat over 840m later in the day.
"He has been back in work for a while and ready to comeback,' Munce said.
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- Getting the vehicle inspected by an inspection agent (if a private sale)
- Purchasing a comprehensive car insurance policy and having the lender added as an interested party
An unsecured car loan, on the other hand, operates like a traditional personal loan. With an unsecured car loan, you have freedom over how you spend the loan funds. This means you can use it to purchase the vehicle and cover associated costs, such as insurance, registration, tyres, aftermarket upgrades and maintenance. Because the loan is unsecured the lender will assess your creditworthiness in assessing your eligibility. This will include considering your credit score, previous credit history, income and current financial position. While unsecured loan rates are generally higher than a secured loan, you should still be able to obtain a low-interest rate if you have a good credit history.
The term "car loan" can sometimes be used to describe the broader family of car financing options available to consumers and businesses. This includes:
Chattel Mortgages. A chattel mortgage is a form of finance where the lender agrees to provide funds for the purchase of an asset, in this case, a car, in return for security over the asset for the duration of the loan term provided the car is predominantly for business purposes. Once the loan is repaid, the mortgage is discharged (similar to a home loan). As is the case with a secured car loan, in the event, you are unable to meet your repayments, the lender may be able to repossess the car.
Chattel mortgages are a popular option for business owners and the self-employed as you own the asset upfront meaning it appears on the balance sheet as an asset and the mortgage as a liability. A chattel mortgage allows a business owner to claim an input tax credit upfront as the purchase price of the car is funded inclusive of goods and services tax (GST). You may also be able to claim interest and depreciation costs based on the proportion of time the car is used for business purposes.
Car Leases. A car lease is a type of finance where the lender purchases the car directly and you agree to make rental repayments over an agreed term. At the end of the lease, you may have an option to purchase the car outright at a reduced price or return the vehicle.
Novated Leases. A novated lease is a form of car lease that is used with salary packaging. With a novated lease you enter into an agreement with the finance provider and a salary sacrifice agreement with your employer to cover the repayment and running costs of the vehicle from the pre-tax income. In turn, your employer makes payments directly to the finance provider on your behalf.
Novated leases have a number of benefits that make them popular. First, as repayments and ongoing running costs come from your pre-tax income, you can effectively reduce your taxable income. Your tax bracket, costs and other consideration will impact how cost-effective this is. Second, motoring costs are effectively GST free for employees as the employer can claim back this tax component of any costs associated with the lease as an input tax credit.
Commercial Hire Purchase. With a commercial hire purchase agreement, the lender agrees to purchase the car for you and hires it back to you for an agreed period (usually 1 to 5 years). You will have full use of the car for the duration of the agreement but it is owned by the financer. Unlike a car lease, however, when the contract comes to an end and the total costs of the vehicle (inclusive of lender interest) have been repaid, ownership of the car is transferred to you. As the name suggests, commercial hire purchases only available for cars used for a business purpose.
At RateSetter, we offer both secured and unsecured car loan products. Secured car loans are available from $10,000 to $100,000 for new, demo and used cars under 7 years old with fixed interest rates. Unsecured car loans are available from $2,001 to $45,000 for a car of any age with both fixed and variable interest rates.
What can I use a car loan for?
With RateSetter, you can use a secured car loan to:
- Buy a new car. Purchase a new car from a dealer including on-road costs.
- Buy a used car. Purchase a used car under 7 years old from a dealer or a private sale.
- Refinance a car. Refinance an existing car loan, lease or balloon payment on a used car under 7 years old.
You can use an unsecured personal car loan to cover any costs associated with purchasing a new or used car, this includes but is not limited to, insurance, registration, tyres, aftermarket upgrades, roadside assistance or pre-paid maintenance agreements. You can also use an unsecured car loan to fund repairs of an existing vehicle.
How much can I borrow with a car loan?
At RateSetter, we offer low-interest secured car loans from $10,000 to $100,000 for new and used cars under 7 years old. We also offer unsecured car loans with a minimum loan amount of $2,001 up to a maximum loan amount of $45,000 for cars of any age.
When you complete your quote, we'll provide you with an initial estimate of your borrowing capacity and the maximum loan amount you are eligible for. You will be able to apply for pre-approval up to this amount, however, we recommend you only apply for what you need to cover the purchase price of the car you are looking to buy or have budgeted for including on-road costs. You pre-approval does not lock you and the final loan amount and repayment options can be changed as part of the settlement process.
How much does a car loan cost?
There are three key features that make up the cost of a car loan. They are the:
- Interest rate (e.g. fixed or variable rate loans)
- Upfront fees (e.g. establishment fee)
- Ongoing fees (e.g. monthly fees, late payment fees, and other charges)
These costs can be combined to create a measure called a comparison rate. This blended rate represents the total cost of the loan over a standard term (e.g. $30,000 over 5 years). This makes it a useful tool to compare car loans on a like-for-like basis along with the proposed monthly repayment.
For an accurate estimate of the costs of your loan, we recommend completing a car loan quote. We'll provide you with a summary of your car loan repayment calculations across different terms. This makes it easy for you to complete a loan comparison with other lenders and choose the right option for you.
At RateSetter, we use risk-based pricing to set the overall cost of your loan. This means we look at a range of factors, including your credit score and financial situation, to provide you with a personalised interest rate. The better your credit history, the better the rate we are able to offer. It's one of the reasons we can offer you a car loan interest rate significantly lower than the big four banks and community credit union. The interest rate you recieve will also be impacted by the type of car loan you choose.
We also don't charge any fees for early or additional repayments. As a result, if you are able to pay back your loan early by making extra repayments and benefit from lower interest you will pay over the life of the loan.
|3 Year
|5 Year
|7 Year
|Loan Type
|3 year car loan (fixed)
|5 year car loan (fixed)
|7 year car loan (fixed)
|Interest Rate
|from 4.69% p.a.
|from 4.69% p.a.
|from 5.19% p.a.
|Comparison Rate*
|from 6.50% p.a.
|from 6.03% p.a.
|from 6.31% p.a.
|Credit Assistance Fee
|from $499
|from $499
|from $499
|Monthly Fees
|Early Repayment Fees
Can I get a car loan?
To be eligible for a RateSetter car loan you must:
- Be aged 21 or over
- Be an Australian citizen or permanent resident
- Be earning over $25,000 per year from a regular source of income that you can demonstrate
- Have a good credit history
- Have at least a provisional or full driver's licence
- Be buying a car that is no older than 7 years
RateSetter will consider a loan application if you are self-employed or can demonstrate a significant recovery from a bad credit history. Additional credit assessment criteria and requirements may apply.
If you are ineligible for a RateSetter secured car loan, we may still be able to offer you an unsecured low rate personal loan that rewards your good credit history. There are no additional steps to take, as part of the quote and loan approval process, we'll make it clear what type of loan you are being offered, what type of rates apply (e.g. variable or fixed rates) and any fees and charges that may apply.
How do I apply for a car loan?
Applying for a car loan with RateSetter is easy and every step can be completed online. You will first need to request a quote. The quote tool will generate your personalised interest rate and includes a car loans calculator that allows you to adjust your loan amount and calculate repayments across different loan terms from 3 to 7 years.
From there you will be able to select your preferred loan option and start your pre-approval application. We'll ask you to share some additional information about yourself and your vehicle purchase. If you have already found a car or are refinancing you'll be able to enter the vehicle details as part of your approval. If you just beginning your search we'll ask you to provide a rough indication of what you are looking for. These details can be updated during the settlement process once you have found a car.
As part of the pre-approval process, we will need you to verify your identity. To complete this step you will need to make sure you have your Australian driver's license handy. We will need to verify your income, expenses and liabilities (e.g. credit cards, loans etc). We will ask you to login to a portal which will allow you to connect with your bank account and share your data with us. You will need your online banking login for your primary transaction accounts and savings account on hand to complete this step. A member of our customer service team will let you know if we require anything further from you.
In completing our pre-approval assessment, we will look for evidence of how suitable a secured car loan is to your situation. This includes reviewing:
- Your employment stability
- Your income (e.g. salary, rent, interest etc)
- Your expenses (e.g. mortgage, groceries etc)
- Your repayment history
- Credit bureau information
- Other details you communicate to us
Once pre-approved you'll be free to shop with confidence. When you've found your vehicle, you'll be able to log on to our online self-service portal to complete the settlement process. Depending on the type of car (new, demo or used) and the method of purchase (dealer vs private sale) the self-service portal will guide you through the documents and steps required to complete your loan (e.g. uploading sale documents or comprehensive car insurance policy details). During this stage, you will have the option to obtain comprehensive car insurance quotes from our insurance provider Huddle, or source your own cover.
We'll review your documentation once submitted and let you know whether anything further is required to finalise settlement of your loan.
*Comparison rates are based on a secured car loan of $30,000 over 60 months. Rates shown assume a customer with an excellent credit history and are current as at 5am, 23 January 2020. RateSetter credit criteria and terms and conditions apply. Warning: This comparison rate is true only for the examples given and may not include all fees and charges. Different terms, fees or other loan amounts might result in a different comparison rate.
Representative Example: Based on a car loan of $30,000 over 60 months a borrower with an excellent credit history can expect to pay a total of $34,813.80. This represents a comparison rate of 6.03% p.a. and includes all interest and fees included in your loan repayments over the life of the loan. RateSetter car loans are available from 3 years to 7 years. Car loan interest rates range from 4.69% p.a. (comparison rate 6.03% p.a.) to 10.79% p.a. (comparison rate 12.10% p.a.).


text:
The combined early wood duck and teal seasons open Sept. 10-14; after that teal-only continues on Sept. 15-18. The daily combined bag limit is six (no more than two wood ducks allowed).
This is the third and final year for the expanded season for teal. Previously it was only the five-day wood duck/teal hunt with a daily bag limit of four ducks. The U.S. Fish and Wildlife Service recommended the experimental season in 2014 because the blue-wing teal population was at record numbers.
Given that, smart money would be on a repeat of the extended season next year. The 2016 numbers for blue-winged and green-winged teal are even better than in 2014: 34 percent above the long term average and more than twice the LTA, respectively.
Comments are closed.
December 2019


text:
Brant M. Olson
Brant M. Olson joined the law firm in 2017 after working for a Seattle litigation firm. His practice emphasizes commercial and residential evictions, and real estate litigation.
Mr. Olson received his law degree cum laude from Seattle University School of Law in 2013. During law school, he served as a judicial extern to the Honorable Justice Mary E. Fairhurst of the Washington State Supreme Court. Mr. Olson interned at Weyerhaeuser Company as well as the Natural Resources Division of the Washington State Attorney General's Office. Mr. Olson received his undergraduate degree from the University of Washington with a major in Law, Societies, and Justice, as well as a major in Political Science.
Mr. Olson is a member of the Washington State Bar Association and King County Bar Association.
For an initial consultation, call 206.443.8678 or complete our Contact form.


text:
Some might find the idea of a self-driving car terrifying. What if it malfunctions and drives straight into a tree, or a ditch? Or worse, another motor! It's for this reason that Google is so careful during its work on self-driving cars. When the search giant revealed its self-driving car project in October, the company assured drivers that the cars were never, ever unmanned.
"We always have a trained safety driver behind the wheel who can take over as easily as one disengages cruise control," said software engineer Sebastian Thun. "And we also have a trained software operator in the passenger seat to monitor the software," he added.
Further, Jalopnik reports that the California Bureau of Motor Vehicles says that these testers are legally considered drivers as they believe autonomous driving software is similar to cruise control.
Still, it seems these trained safety drivers may not be following the letter of the law. A Jalopnik reader sent the following image of the driver of one of Google's self-driving Priuses. The man appears to be talking on his cell phone, which has prompted many to cite the Bureau of Motor Vehicles declaration that these people are legally the drivers of the car and shouldn't be making phone calls but paying attention to the road. The only problem is that you can't actually see a cell phone in the guy's hand, and the person taking the picture, unless stopped at a traffic light or stop sign, was also using his or her own phone. Oops!
Source: Jalopnik


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12.07.2017 16:53:20 Kir:
It's never the factless story that is fake, so long as it confirms what they wish to be true, but the facts that disprove the story, which have been made up or fake. The alternative, that they are not infallible after all, is simply to horrific for them to entertain.
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text:
Public Awareness and Perception of Dental Implants in Randomly Selected Sample in Kuwait
Received Date: Jun 28, 2017 / Accepted Date: Jul 07, 2017 / Published Date: Jul 14, 2017
Background: The growing success of dental implants has made this treatment mode increasingly more popular for the replacement of missing teeth. The aim of this study was to assess public awareness and determine patient's expectations concerning dental implants through requisite information on treatment mode, prior to presenting for professional consultation on dental implant, as a treatment option. Materials and methods: In a cross-sectional survey, 527 adult participants were interviewed, through random selection from attendance at public places. A structured questionnaire, with multiple-choice questions, was used to obtain the participants' level of knowledge on dental implants, including the source of information on which they based this knowledge, their reasons to accept or reject dental implant treatment, as well as their understanding of the procedures involved. Results: In all, (96.4%) of participants had heard of dental implants, and (79.2%) were willing to learn more about dental implants. Almost, two-third (64.9%) of the respondents thought dental implant to be the healthiest treatment mode for missing teeth. Maximum (33.9%) participants gathered dental implants information through media, followed by friends or social gatherings (24%), dental clinics (23.3%), and family (18.8%). Significantly more females than males, and more Kuwaitis than non-Kuwaitis expressed, 'Good looking', the reason for acceptance for dental implants (p<0.05). Conclusion: This study revealed a high level of awareness among public, but lack of knowledge on procedural aspects. The study also revealed the need for specialists in this field to spread awareness and relevant information concerning dental implants among the general public.
Keywords: Dental implants; Public awareness; Acceptance; Information sources
Dental implant is increasingly becoming a widely accepted treatment approach in dentistry for the replacement of missing teeth. The success and good prognosis of this treatment has made it very popular among the dentists, offering implant-supported rehabilitation to patients having lost teeth, or those with severely compromised bone structure [1-5]. Though oral reconstruction has been going on since late 1950s with the intra-oral use of titanium implants, the public perception of this mode of treatment has largely remained unmeasured, despite reported improvements in patients treated with implant-supported prosthesis. Several studies from different countries do report the level of patients' understanding and awareness concerning oral implants [6-13]. However, in Kuwait, dental implant treatment is relatively a new field, hence, public perception of this treatment has never been studied. Being a novel approach, and a surgical intervention, public invariably remains apprehensive of the associated complications, despite the potential benefits of this treatment regimen in tooth-restoration, improving patients aesthetics, self-confidence and quality of life.
From clinicians' experiences in Kuwait, the suggested option of dental implant for replacing missing tooth is often met with reluctance among patients, fearful of surgical outcomes. The basis of our study is inherent in this widespread hesitancy and fear syndrome among the public, making it imperative to probe the extent of public perception and awareness concerning the dental implant treatment in Kuwait. The study is first of its kind, and expected to generate baseline data for mapping a strategy for orienting and educating the public on the positive implications of this field of dentistry in Kuwait, in addition to contributing to existing knowledge in the field from this part of the world.
Vast literature exists in the field of dental implants, covering various aspects of this treatment approach, including treatment planning, surgical placement, survival rate, success rate, patient-satisfaction concerning the treatment outcome, etc. [14-21]. Yet, few studies have reportedly been attempted on the patients' perception of the surgical procedures associated with dental implant placement. The aim of this study was to assess public awareness, determine patients' expectations, and enhance their understanding of procedural implications through requisite information about dental implants, prior to presenting for professional consultation on dental implant as a treatment option [22,23].
Materials and Methods
A cross-sectional survey, among 527 participants was conducted in the general public through personal interviews utilizing a structured questionnaire with multiple-choice questions, during a period of four months - Oct 2014 to Jan 2015. The targeted subjects were randomly selected from attendance at local malls, supermarket and food convention open for the general public. The questionnaire included personal data, level of education, and a brief dental history. The questions were intended to solicit the level of participants' knowledge concerning dental implants, and the source of information on which they based this knowledge. All the four interviewers in the survey had dental background, and the questionnaire was both in Arabic and English, used as per the subject language preference.
Statistical analysis
The data management, analysis and graphical presentation were carried out using the computer software 'Statistical Package for Social Sciences, SPSS version 22.0' (IBM Corp, Armonk, NY, USA). The descriptive statistics has been presented as number and percentage for categorical variables, and mean ± standard deviation (SD) for continuous variable, age. Chi-square or normal Z-test, for comparing two proportions, was applied to find any association or significant difference between categorical variables. The two-tailed probability value 'p'
Sample demographics
A total of 527 respondents were interviewed, of which 28 had to be excluded on account of incomplete questionnaire. In all, 499 survey participants, giving a response rate of 94.7%, were included for data analysis, comprising 240 (48.1%) males and 259 (51.9%) females (Table 1). Nationality-wise, these included 287 (57.5%) Kuwaitis and the remaining 212 (42.5%) non-Kuwaiti expatriates. Maximum respondents, 248 (49.7%) were in the age group 29-50 years, 196 (39.3%) in the age group (18-28) years, and 55 (11%) were above 50 years. No significant difference was noticed, either in terms of gender or nationality with respect to different age groups. The overall mean age was found to be 35.3 (±11.3 SD) years, ranging between 23 and 58 years. Majority (63.7%) of the respondents were college or university educated, 27.4% had finished their schooling, and only 8.9% had some school education. A significantly higher proportion of elderly respondents, above the age of 50 years, were observed among school educated, in comparison to younger age groups having college or university education (p<0.001).
|Sample Demographics
|Age (years)
|196 (39.3)
|248 (49.7)
|51 and above
|55 (11.0)
|240 (48.1)
|259 (51.9)
|Nationality Status
|287 (57.5)
|Non Kuwaiti
|212 (42.5)
|Less than High School
|44 (8.9)
|Finished High School
|136 (27.4)
|Technical College/Institute Diploma
|120 (24.2)
|University Student/ Graduate
|160 (32.3)
|University Higher Education
|36 (7.2)
Table 1: Respondents demographic characteristics (N=499).
Awareness and source of information about dental implants
Of the total 499 respondents, 96.4% had heard of dental implants, with more females (97.7%) than males (95%) being aware of this treatment regimen. In all, 79.2% were willing to learn more about dental implants. Maximum respondents obtained dental implants' information through such media channels as television, radio, newspaper or internet (33.9%), followed by those having heard about this treatment through friends or in social gatherings (24%) (Figure 1). In addition, dental clinics were the source of information for 23.3% respondents, while (18.8%) reportedly heard about dental implants from family members.
Awareness and knowledge on treatment for a missing tooth
Almost two-third (64.9%) of the respondents thought dental implant to be the healthiest treatment mode for replacement of missing teeth, while 17.7% and 2.2% respectively considered fixed partial denture, and removable partial denture, as the preferred treatment for missing teeth. The remaining, 13.2% did not have any knowledge on this, and 2% thought there was no treatment for missing teeth. When asked, if they would go for surgical placement of dental implant for a missing tooth, 65.7% said 'yes', 18.4% 'no', and 15.9% 'may be'.
Acceptance or refusal to dental implant treatment
Of the total respondents, 74.6% enlisted their acceptance of the dental implant treatment, 20.8% were not receptive to this treatment mode, and 4.6% did not respond. More females than males (81% vs. 75%) and more Kuwaitis than non-Kuwaitis (80% vs. 76%), showed their willingness for dental implants.
Perception towards dental implants
Placement: Almost two-third of the respondents (64.6%) considered implant placement as a difficult procedure, while remaining 35.4% considered it to be a simple procedure (Table 2). As many as 43.3% respondents considered it to be a very painful procedure at the time of placement, compared to 56.7% who thought it to be comfortable with no pain, but on the contrary, a higher percentage (54.1%) of respondents thought the procedure to be more painful after the implant placement, in comparison to 45.9% who found the procedure comfortable with no pain.
|Perceptions towards dental implants
|How difficult, do you think, is dental implant placement?
|Very difficult
|106 (21.4)
|Somewhat difficult
|214 (43.2)
|142 (28.7)
|Very simple
|33 (6.7)
|How painful, do you think, is dental implant placement
(at the time of placement)?
|Very painful
|68 (13.6)
|Somewhat painful
|148 (29.7)
|Relatively comfortable procedure
|120 (24.0)
|No pain is involved
|163 (32.7)
|How painful, do you think is dental implant placement
(after the implant is placed)?
|Very painful
|102 (20.4)
|Somewhat painful
|168 (33.7)
|Relatively comfortable procedure
|155 (31.1)
|No pain is involved
|74 (14.8)
|How dangerous is the implant procedure (the surgery)
|Very dangerous
|43 (8.8)
|Somewhat dangerous
|127 (25.6)
|Relatively dangerous
|94 (18.9)
|Not dangerous
|233 (46.9)
|How dangerous is it, having a metal screw in your jaw bone?
|Very dangerous
|55 (11.1)
|Somewhat dangerous
|93 (18.7)
|Relatively dangerous
|Not dangerous
|233 (46.9)
|How successful are dental implants in replacing missing
teeth in the long run?
|Very successful
|205 (41.6)
|Somewhat successful
|183 (37.1)
|Relatively successful
|77 (15.6)
|Not successful
|28 (5.7)
|How comfortable do you think living with an implant
placed in your jaw bone
|Very comfortable
|196 (39.5)
|Somewhat comfortable
|158 (31.9)
|Relatively comfortable
|87 (17.5)
|Not comfortable
|55 (11.1)
Table 2: Respondent's perceptions towards dental implants.
Procedure: More than half of the respondents (53.1%) had perceived implant procedure or surgery, as well as considered having a metal screw in the jaw bone as dangerous, compared to remaining 46.9%, who did not regard it as dangerous. A higher percentage (94.3%) was found to consider dental implants successful in replacing missing teeth in the long run, while 89.9% thought the implant placed in jawbone quite comfortable.
Reasons to accept or reject dental implant treatment:
Maximum (28.7%) respondents considered dental implant as the best solution, comfortable and a successful treatment for missing teeth (Figure 2). The next most common reason (16.7%) to accept dental implant was its aesthetic value, like the natural teeth, followed by 'better than any surgery or bridge' (13.6%). The other reasons for acceptance were, 'can eat and smile properly (7.3%),'last for long duration' (5.7%) and 'can't live with missing teeth' (5.0%). The reasons for rejecting dental implants were mainly, 'afraid of surgeries or doctors' (7.0%), and 'afraid of pain or other conditions like diabetes' (3.5%). The other reasons to reject were, 'bridge is better than implant' and 'don't care for missing teeth' each, mentioned by 2.2% of the respondents. Additional reasons mentioned under the 'Others' category constitute about 8.2% of the total respondents.
Gender-wise, female's acceptance to dental implants was higher in comparison to males, especially the reason cited as 'good looking' (21.2% vs. 11.8%, p<0.034), (Table 3). No significant difference was found between males and females as regards reasons for rejection. Nationality-wise, more Kuwaitis cited the reason for acceptance as 'Good looking', which was significantly higher than non-Kuwaitis (20.3% vs. 9.5%, p<0.024), while the proportion of non-Kuwaitis was significantly higher than Kuwaitis (36.2% vs. 25%, p<0.017), concerning the reason 'Best solution, comfortable and successful'.
|Reasons to accept or reject dental implant treatment
|Non Kuwaiti
|To Accept
|Good looking (like natural teeth)
|18 (11.8)
|35 (21.2)*
|43 (20.3)*
|10 (9.5)
|53 (16.7)
|Best solution, Comfortable, Successful
|39 (25.7)
|52 (31.5)
|53 (25.0)
|38 (36.2)*
|91 (28.7)
|Better than any surgery or bridge
|21 (13.8)
|22 (13.3)
|28 (13.2)
|15 (14.3)
|43 (13.6)
|Can eat and smile properly
|16 (10.5)
|7 (4.2)
|14 (6.6)
|9 (8.6)
|23 (7.3)
|Last for long duration
|9 (5.9)
|9 (5.5)
|15 (7.1)
|3 (2.9)
|18 (5.7)
|Can't live with missing teeth
|10 (6.6)
|6 (3.6)
|10 (4.7)
|6 (5.7)
|16 (5.0)
|To Reject
|Afraid of doctors /Surgeries
|12 (7.9)
|10 (6.1)
|14 (6.6)
|8 (7.6)
|22 (7.0)
|Afraid of pain and other problems
|5 (3.3)
|6 (3.6)
|10 (4.7)
|1 (1.0)
|11 (3.5)
|Bridge is better than implant
|3 (2.0)
|4 (2.4)
|5 (2.4)
|2 (1.9)
|7 (2.2)
|Don't care for missing teeth, old age
|3 (2.0)
|4 (2.4)
|5 (2.4)
|2 (1.9)
|7 (2.2)
|16 (10.5)
|10 (6.1)
|15 (7.1)
|11 (10.5)
|26 (8.2)
Note: *M vs.F (p<0.034) and K vs.NK (p<0.024), (p<0.017)
Table 3: Respondents reasons for dental implant according to gender and nationality.
Dental implants appear to be an increasingly successful substitute for the replacement of missing teeth, as reported in several studies worldwide. However, the extent of awareness concerning this procedure in Kuwait has remained undetermined, with no previous studies addressing this aspect from this part of the world. To study implant awareness in different counties, various studies have reported different levels of awareness on dental implants, with maximum being from Austria (79%) and US study (77%), followed by Norway (70%) (Table 4). Though, studies from Jordan (2014) and Kuwait (the present study) have reported the percentages (96%) based on those respondents, who had heard of dental implants. Another Jordan study (2010) reported only 44% of awareness. Studies from India showed variant levels, between 23% and 38%. In Gulf, a study from Saudi Arabia had reported (66%) awareness level.
|Awareness (%)
|Austria [10]
|Norway [8]
|Andhra Pradesh, India [9]
|Jaipur, Rajasthan, India [9]
|India [11]
|Malaysia [23]
|Turkey [13]
|Jordan [9]
|Jordan [14]
|Riyadh, Saudi Arabia[19]
Note: *Present Study
Table 4: Awareness of dental implants in various countries.
Our study is seemingly an initial venture concerning this procedure, with the prime objective of gathering preliminary data on popular public response pattern and awareness on dental implants, in an effort to lay a basis for a more advanced and comprehensive study in future that could provide the substance for developing an organized strategy for sensitizing the public to the potential benefits and implications of dental implants as a preferred treatment modality. The need for such an effort is implicit in the analytical findings of our survey, exhibiting a very high level of awareness concerning dental implants among the public, though the source of their information being largely various media channels, family members or social gatherings, as has been reported in other studies by Berge [8], Pommer et al. [10] and Al-Johany et al. [19] rather than through dental professionals, which apparently is a matter of concern. However, in a recent study on Turkish population, Tomruk et al. [13] does report that a large proportion preferred to have the information on dental implants from their dentists. Patients exhibiting increasing interest in opting this treatment regimen, with females exhibiting higher receptivity to dental implants due to its long-lasting, aesthetic and comfort value, a finding that is widely reported in other studies from around the world. The biggest hurdle to this procedure was apparently the wide spread perception towards surgical intervention and the associated pain, which despite implant surgery being a relatively simple procedure, a high percentage of our subjects interviewed, considered it a relatively difficult surgery. To a large extent, this perception is commonly associated with all types of surgical procedures, and in the context of dental implants, a more proactive role by dental professionals in spreading awareness could go a long way in removing some of the misconceptions currently prevalent among the general public concerning this treatment mode. Our study does reveal an encouraging aspect, with only a small percentage of respondents (5.7%) perceiving dental implant to be unsuccessful in replacing missing teeth in long run, or reporting a feeling of discomfort (11.1%) while living with an implant placed in the jaw bone. To a majority of respondents it appeared a preferred mode of treatment, exhibiting a growing receptivity of the public towards dental implants as an acceptable solution for replacing the missing teeth.
This study revealed a high level of awareness among public on the potential benefits of dental implants for the replacement of missing teeth, yet there appeared a lack of knowledge on procedural aspects of the treatment. The study is a distinct pointer to lack of system or strategy for organized transmission of information on dental implants and implications of this treatment mode for the awareness of the public, and calls for a more proactive role of dental professionals and specialists in the field, to sensitize the public on the potential benefits of this treatment through the dissemination of relevant information, rather than the public reliance on media, news reporting, family or social gatherings. There appears a dire need for source information to be relayed through specialists, responsible for this treatment regimen, rather than leaving the public open to unorganized and unauthentic information sources.
Being the first study of its kind, its significance lies in providing basic insight into the general public perception, knowledge and mode of acquiring information on dental implants and related procedures. Despite being a preliminary study, apart from contributing to existing information in the field, our findings tend to open the door for laying a framework for public dissemination of precise information through specialists and dental professionals in the field, for spreading awareness among the general public on the benefits of this treatment mode in Kuwait.
We would like to express our appreciation to all the participants who agreed to be part of this survey, and helped us in completing the study questionnaire.
Source of Support
The study was concluded without any support, what so ever.
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Citation: Al-Musawi A, Sharma P, Maslamani M, and Dashti M (2017) Public Awareness and Perception of Dental Implants in Randomly Selected Sample in Kuwait. J Med Imp Surg 2: 116.
Copyright: © 2017 Al-Musawi A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Pizza Hut on Dangers of Selfie Sticks
Pizza Hut has released "The Dangers of Selfie Sticks PSA", a comedic creative content campaign promoting the two foot Big Flavor Dipper Pizza. A woman standing in an art gallery introduces the faux public service announcement with a warning about the latest trend in selfies, using the selfie stick to take in more. The basic concept is contained in the @PizzaHut Twitter post: "Bigger pizza means bigger selfies. Please selfie responsibly."
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Dangers of Selfie Sticks Credits
The Pizza Hut Dangers of Selfie Sticks PSA was created, produced and distributed by Shareability, Los Angeles.
Filed under: Commercials, Pizza Hut
Tagged: Shareability
Location: USA


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Flower Power
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Wine Songs, Vinegar Verses
Sometimes lovers enter a relationship with the best of intentions but wind up in a place far from love.
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Work will be performed worldwide and is expected to wrap up in June 2021.
Twenty-eight companies bid on the contract, leaving seven companies without awards.
The contract was awarded by the Space and Naval Warfare Systems Center Atlantic, Charleston, S.C.
About the Author
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The Capital Project
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Treatment of metastatic cervical cancer with chemotherapy and targeted therapy
Dr. Amy Chang
Specialist in Clinical Oncology
Hong Kong
Presentation and management
A 40-year-old Chinese female presented to the clinic in March 2014 after an episode of postcoital bleeding. She had been undergoing annual cervical smear examinations, with no abnormal findings noted. Her past medical history was unremarkable. Physical examination revealed a 4 cm necrotic mass at the cervix, which was assessed on biopsy to be an invasive non-keratinizing squamous cell carcinoma. MRI did not reveal any metastasis or lymph node involvement, and the patient's disease was classified as stage IB.
In June 2014, the patient underwent Wertheim's hysterectomy, bilateral salpingo-oophorectomy and bilateral pelvic lymphadenectomy. Histopathological examination of the tumour revealed a large-cell non-keratinizing squamous cell carcinoma measuring 7 cm in diameter with clear resection margins. None of the 26 lymph nodes resected were positive for malignancy. There was note of deep stromal invasion but no lymphovascular or perineural permeation. As the tumour was larger than the expected diameter of 4 cm, the patient's disease stage was reclassified to stage IB2.
The patient received postoperative whole pelvis radiotherapy with a dose of 50 Gy given in 25 fractions over a period of 5 weeks. The treatment was completed in September 2014. Follow-up visits to the clinical oncology service and the gynaecology service were scheduled every 3 weeks. No evidence of relapse was noted during these visits until April 2015, when the patient began to experience a mild, dry cough, and surveillance CT scan revealed multiple lung metastases. During this period, her Eastern Cooperative Oncology Group performance status was 1. Follow-up PET scan showed multiple lung and mediastinal lymph node involvement. The metastases numbered greater than 8 and were considered inoperable.
Palliative chemotherapy was initiated and consisted of Paclitaxel 175 mg/m2 and Cisplatin 50 mg/m2, together with Bevacizumab at a dose of 15 mg/kg. Therapy was administered every 3 weeks, to complete a total of six cycles. An improvement in her cough was noted after the first cycle. The treatment was well tolerated, with only mild grade 1 peripheral neuropathy noted. A progress CT scan in August 2015 after five cycles of chemotherapy showed a reduction in size of the lung metastases. (Figure) The patient has completed the planned six cycles of palliative chemotherapy and will be maintained on Bevacizumab 15 mg/kg every 3 weeks until disease progression.
Figure. CT scan after five cycles of Paclitaxel, Cisplatin and Bevacizumab showing reduction in size of lung metastases (B) compared with baseline (A)
Patients with metastatic cervical cancer have limited survival.1 The presence of multiple metastatic lesions makes these cases inoperable.2 Thus, the remaining treatment option in this setting is chemotherapy, usually with a platinum-based regimen, such as Cisplatin or Carboplatin, plus Paclitaxel. For patients who cannot tolerate platinum-based chemotherapy, Topotecan may be given in place of Cisplatin.2
Bevacizumab, a humanized anti-VEGF antibody, has demonstrated activity as monotherapy in previously treated patients with recurrent cervical cancer.3 A recent study evaluated the efficacy of Bevacizumab added to standard Cisplatin or Topotecan plus Paclitaxel chemotherapy in patients with metastatic, persistent or recurrent ovarian cancer. A total of 452 patients were randomized to receive either chemotherapy alone or chemotherapy plus Bevacizumab. Median overall survival was significantly prolonged in patients who received Bevacizumab in addition to standard chemotherapy compared with patients who received chemotherapy alone (17 vs 13.3 months; hazard ratio, 0.71; p=0.004) – a survival benefit of 3.7 months.3 Patients who received Bevacizumab in addition to chemotherapy also had significantly higher response rates (48 vs 36 percent; p=0.008). Notably, however, there was a higher incidence of hypertension and thromboembolic events in the group receiving Bevacizumab.
Since both Cisplatin and Paclitaxel can cause peripheral neuropathy, the emergence of this side effect may be a limiting factor in the treatment of patients receiving these agents. However, our patient tolerated the treatment well, experiencing only grade 1 peripheral neuropathy.
In summary, this case illustrates the successful use of chemotherapy combined with targeted therapy in the management of metastatic cervical cancer. In our patient, the treatment has resulted in a fairly long duration of disease control and was well tolerated.
1. American Cancer Society. Cervical cancer: survival rates by stage: http://www.cancer.org/Cancer/CervicalCancer/DetailedGuide/cervical-cancer-survival.
2. J Clin Oncol 2007;25:2966-2974.
3. N Engl J Med 2014;370:734-743.
This special report is made possible through an unrestricted educational grant from the industry and first appeared in MIMS Oncology.