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Nanomedicine May Provide New Hope for Brain Cancer Therapy
Alain L Fymat*
International Institute of Medicine & Science, USA
Submission: November 18, 2018;Published: December 06, 2018
*Corresponding author: Alain L Fymat, International Institute of Medicine & Science, California, USA
How to cite this article: Alain L Fymat. Nanomedicine May Provide New Hope for Brain Cancer Therapy. Glob J Nano. 2018; 4(5): 555647. DOI: 10.19080/GJN.2018.04.555647
Cancer cells are notoriously resistant to drugs intended to kill them by rerouting signaling networks responsible for cancer growth, proliferation and survival. They also contribute to drug resistance to conventional treatment and high recurrence rates. For brain cancers (glioblastomas), the brain protective barriers, particularly the blood brain barrier, inhibit or even preclude the entry of many (if not most) therapeutic drugs. Because of this barrier, the several drugs approved by the FDA have had little effect. Fortunately, nanobiotechnology has come to the rescue offering nanoparticles and nanodevices to ferry therapeutic drugs across the barrier and deposit them theoretically at the right location, at the right time, and in the right dosage or dose fractionation. These developments are described below, and comments are made regarding the needed advances in nanobiotechnology as well as the lacking understanding of the deep biology of glioblastomas.
Keywords: Blood brain barrier; Glioblastoma; Nanodevices; Nanoparticles; Nanobiotechnology
Abbrevations: BBB: Blood Brain Barrier; BPB: Blood Protective Barriers; CSF: Cerebro Spinal Fluid; CNS: Central Nervous System; CT: Computed Tomography; FDA: Food and Drug Administration; GB: Glioblastoma; GBM: Glioblastoma Multiform; 3HM: 3-Helix Micelles; LPH: Lipid-Coated Polymeric Hybrid; MDR: Multiple Drug Resistance; NBT: Nanobiotechnology; MRI: Magnetic Resonance Imaging; ND: Nanodevices; NGP: Neural/Glial Progenitors; NM: Nanomedicine; NP: Nanoparticles; NSC: Neural Stem Cells; PET: Positron Emission Tomography; P-gp: P-Glycoprotein; PLGA: Poly Lactic Co-Glycolic Acid; PNP: Polymeric NPs; RCT: Rational Combination Therapy; SERS: Surface-Enhanced Raman Spectroscopy; TAC: Transit Amplifying Cells; TIC: Tumor Initiating Cells
Drugs: Bradykinin; Casomorphion; Mannitol; Osteopontin.
Cancer cells are notoriously resistant to drugs intended to kill them. They reroute signaling networks responsible for cancer cell growth, proliferation and survival. A drug may block a signaling pathway but within days (at times minutes), cancer cells rely on alternate pathways to promote their survival. The simultaneous use of several drugs, called "rational combination therapy" (RCT) aims to block pathways (primary and alternate) to pre-emptively block escape routes. Unfortunately, RCT has limited efficacy because drugs have different chemical properties, travel to different parts of the body, and enter cancerous cells at different rates. This illustrates one of the many treatment difficulties for cancer.
The situation is further complicated by the fact that cancer cells with stem cell-like properties reside in a protective niche around arterioles, maintaining a hypoxic environment and extending their tendrils into surrounding tissues. They also contribute to drug resistance to conventional treatment and high recurrence rates. In the case of brain cancers (including glioblastomas, also called glioblastoma multiform, GBM), the situation is compounded by the presence of protective barriers (BPBs), more particularly the blood brain barrier (BBB), that preclude the entry of many (if not most) therapeutic drugs.
Several drugs have been approved by the FDA for brain cancer treatment, all with little impact because the BBB limits their accumulation. Fortunately, drugs encased in nanoparticles (NP) and delivered by nanodevices (NDs) can overcome these limitations. These will be described below including particularly special liposomes (size: 110 nm) and micelles (self- assemblies of peptides and polymers, size: 20nm). However, micelles have so far only been demonstrated in rats using radiolabeling with copper (Cu-64). To evaluate the different BBB responses, and to quantitatively study the behavior of the BBB, a database exists ("Brainpeps"), providing transport information and prioritizing peptide choices. As an example, Casomorphion (a heptapeptide) is able to pass the BBB.
On Glioblastomas
Figure 1 is a schematic representation of the development of a glioblastoma from a neural stem cell. It shows the following processes in GBM formation:
From neural stem cells (NSC) to transit amplifying cells (TAC) to neural/glial progenitors (NGP), to tumor initiating cells (TIC).
From TIC to GBM.
Conversion of NGP to TIC via Oligodendrocytes and Astrocytes
Glioblastomas (GBs) or glioblastomas multiform (GBMs) are the most common, most aggressive primary brain tumors in adults, accounting for ~ 15% of all brain tumors and 3.19 cases/100,000 patients/year. The average age at diagnosis is 64 with a median survival time of ~ 3 months (up to 1-2 years with treatment), the most common being 12-15 mos (3%-5% surviving more than 5 years) (Figure 2 & 3).
The first treatment line for GBMs was defined since 2005, but there is no standardized second treatment line for recurring tumors and no prevention strategy. Whereas several risk factors have been identified, let us recall this author's admonition that "risk is not cause and risk management is not cure (only palliation)". Unfortunately, most treatments cannot eradicate most tumor cells.
I have discussed elsewhere the surgical and non-surgical management and treatment of GBMs, including the cases of primary, secondary and recurring tumors Fymat [1-3]. That discussion included their morphology, biological types, risk factors, and prognosis. It also included the various management and treatment approaches including several surgical and non-surgical therapies: symptomatic, palliative, surgery, complementary and alternative, conformal, boron neutron capture, intensity-modulated proton beam, chemotherapy, antiangiogenic, alternating electric, immunotherapy, vaccines and lifestyle changes. Figure 4 & 5 show respectively a surgical total resection of a GBM and an excised brain showing the same.
The most serious impediment in the treatment of GBMs is posed by the brain protective barriers (BPBs) that hinder or preclude the penetration and delivery of most therapeutic drugs as next discussed.
On the Brain Protective Barriers
Being the most delicate organ of the body, the brain is protected against potentially toxic substances by the brain protective barriers (BPBs), four of which under the collective term "blood-brain barrier" (BBB) describe the four main interfaces between the central nervous system (CNS) and the periphery [4]:
The BBB proper
It is formed by complex tight junctions between the endothelial cells of the cerebral vasculature. Its primary manifestation is the impermeability of the capillary wall due to the presence of the junctions and a low endocytic activity;
The blood-cerebro spinal fluid (CSF) barrier
It is formed by tight junctions between epithelial cells of the choroid plexus. Both the BBB proper and the blood-CSF barrier extend down the spinal cord;
The outer CSF-brain barrier
It is formed by tight junctions between endothelial cells of the arachnoid vessels (the pia arachnoid); and
The inner CSF-brain barrier
It is formed by strap junctions between the neuro-ependymal cells lining the ventricular surfaces. It is present only in early development and absent in the adult.
The above barriers and the blood retinal barrier (not studied here) are parts of a whole realm of barriers. We are here essentially interested in the BBB proper (Figure 6).
The BBB is a continuous lipid physical and physiological bilayer, constituting the major obstacle that restricts the entry of most pharmaceuticals and polar and lipid-insoluble substances and drugs into the brain. Therapeutic molecules and antibodies that might otherwise be effective in diagnosis and therapy do not cross the BBB in adequate amounts. Extensive efforts are therefore being made to come up with drug delivery strategies that would enable the passage of therapeutic molecules safely and effectively. Such strategies involve modifying the drug itself or coupling it to a vector for receptor-mediated or adsorptionmediated transcytosis [5,6].
Various attempts have been made to overcome the limited access of drugs to the brain, e.g. chemical modification, development of more hydrophobic analogs or linking an active compound to a specific carrier. Transient opening of the BBB in humans has been achieved by intracarotid infusion of hypertonic mannitol solutions or of bradykinin analogs. Another way to increase or decrease brain delivery of drugs is to modulate the P-glycoprotein (P-gp) whose substrates are actively pumped out of the cell and into the capillary lumen. Many P-gp inhibitors or inducers are available to enhance the therapeutic effects of centrally acting drugs or to decrease central adverse effects of peripherally active drugs. Nonetheless, overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to the treatment of most brain disorders. We are here mostly interested in the use of nanomedicine technologies, which may provide new hope for brain cancer therapies.
Use of Nanomedicine Technologies
Nanobiotechnology (NBT) can deliver drugs across, around, and beyond the BBB at the right location, the right time, and in the right dosage. Receptor-mediated transport systems enable molecules to cross the BBB in vivo. Although there are FDAapproved therapeutic drugs for the treatment of GBM, these treatments have had little impact on patient survival rate because the BBB has limited the accumulation of therapeutics within the brain.
We shall distinguish between the nanoparticles (NPs) and the nanodevices (NDs) that carry them and transport them across the BBB.
Of the multiplicity of NPs that are available, currently only two are of direct application to brain tumors, namely, gelatin NPs for delivering multiple drugs and, even more promisingly, lipid-based surface-engineered PLGA nanoparticles. These are briefly reviewed below. Other NPs that have been applied to other cancers but not yet to GBMs will not be considered here. The latter include: nutshells; microbubbles; the surface-enhanced Raman spectroscopy (SERS) nanotags; platelet-coated NPs; shapeshifting engineered NPs; kinase inhibitors in NP formulation; bioavailability-improved NPs and molecules; lipid-polymers and polymeric hybrid NPs; hybrid nanocrystals; and superparamagnetic iron oxide NPs (for a detailed review, see Fymat [7].
Gelatin nanoparticles for delivering multiple drugs to the brain
Gelatin is biocompatible, biodegradable, and generally recognized as safe by the U.S. Food and Drug Administration (FDA). Gelatin NPs are laced with the drug osteopontin and administered intra-nasally along the olfactory nerve cells – a noninvasive and direct route to the brain, to reduce inflammation and prevent brain cell death. This delivery pathway bypasses the BBB. It can be most effective in delivering drugs that cannot otherwise cross the barrier, and it can deliver therapeutic agents to specific regions of the brain. Once administered, the gelatin NPs target damaged brain tissue thanks to an abundance of gelatin-munching enzymes produced in injured regions. As far as is known, gelatin particles have not yet been used clinically to treat GBMs.
Lipid-based surface engineered PLGA nanoparticles:
Polylactic co-glycolic acid (PLGA)-based nanocarriers are one of the most promising drug delivery system for crossing the BBB. While they offer great promise, they nevertheless present several major challenges and intrinsic drawbacks, and require further engineering for clinical and research applications. These challenges include:
a) Synthetic hydrophobic surface,
b) Low transfection efficiency
c) Short circulation half-life and
d) Nonspecific tissue distribution.
To overcome these problems, numerous engineering strategies have been employed with lipid-based surface functionalization of PLGA NPs showing the following promising results:
i. Enhancement of target specificity of the carrier,
ii. Improvement of its physicochemical properties,
iii. NP-cell associations such as cellular membrane permeability,
iv. Immune responses and
v. Long in vivo circulation half-life [8].
These challenges can be classified in three major categories:
a. First generation NPs involving strategies to facilitate travel from the injection site;
b. Second generation NPs involving BBB pre-transcytosis to enhance passage across the brain endothelial cells; and
c. Third generation NPs to achieve targeting of the impaired system cells (post-transcytosis strategies). A fusion of all or some of these strategies may be required to engineer multi-functional PLGA NPs for treating brain cancers (and also neurological disorders) for which pharmaceutical treatments have been limited due to drug access to the central nervous system (CNS).
Nanodevices for Drug Delivery
Engineered nanoscale devices (ENDs) are minute devices with the potential to be engineered to efficiently and more safely deliver drug treatments directly to the location of diseased cells while helping avoid harm to healthy cells that fall victim to toxic drugs administered by conventional means. Because of their diverse capabilities, nanoscale devices can contain both targeting and therapeutic agents (in both single and multidrug approaches). They can deliver high drug levels in several situations, including anticancer drugs at the tumor site that can increase chemotherapeutic efficacy. They can also offer the opportunity to develop new approaches to therapy, including "smart" nanotherapeutics to "time" the release of any given drug or to deliver multiple drugs sequentially in a timed manner or at several locations in the body.
Miniaturized devices loaded with life-saving drugs may revolutionize chemotherapy, reducing the debilitating side effects of the therapy, making medications more effective, and all the while preserving the healthy living cells. The same systems could likewise be used for delivering clot-busting drugs to the brain. Several "nano-carriages" for drug delivery have been created but many challenges remain, chief among them being how not to let the medicine act before it gets to the right location in the brain. The carriers usually encapsulate drugs through long-range electrostatic interactions wherein the carrier attracts oppositely charged medicines. Other tools are available to trigger the release of drugs, for example, an external magnetic field, ultrasound waves, different pH values, etc. But, in each case, researchers face the problem of efficiency of the drug release. The following nanodevices (NDs) are available.
The Multi-Layered Shell:
It consists of (a) a core vesicle containing both hydrophilic and hydrophobic drugs; (b) a multilayered shell; and (c) an exterior layer. The purpose of the multilayered shell is to stabilize the NPs, prevent drug leakage, target the NPs to the slightly acidic environment of the tumor, and minimize the NPs' interactions with non-cancerous cells. It can also be used to transport drugs that are not easily stored in the core such as highly charged nucleic acids [9,10].
Multi-shell hollow nanogels with responsive shell permeability:
Departing from the multi-layered shell design, and irrespective of any electrostatic force (i.e., whether the medicines are either charged or neutral), gel nano-capsules are filled by the guest molecules, locking the molecules in the cavity and releasing them under temperature control. The carrier is surrounded by two "membranes" (or shells) of different chemical structures around a silica core which, at the end of the synthesis, will be chemically dissolved leaving only the "empty space" (cavity). The outer porous shell plays a protective (stabilizing) role and hinders aggregation of the nano-capsules, while the pores of the inner shell can open and close depending on the temperature. At the time of filling, the pores of both shells are open and the nanogel absorbs the drug molecules like a sponge. Then, the temperature changes and the pores of the inner shell close locking in the cavity and readying the drug for delivery. Subsequently, the pores will open again and the guest molecules will be released only in the places where the temperature allows (Figure 7).
Helix micelles for brain cancer therapy:
Nanobiotechnology (NBT) has a fundamental role to play in the treatment of GBMs. What is desperately needed is a means of effectively transporting therapeutic drugs through the BBB. Typically, GBM-therapeutics are ferried across the BBB in special liposomes (size ~ 110 nm). By contrast, an interesting device is the one presented by a new family of nanocarriers formed from the self-assembly of amphiphilic peptides and polymers, called "3HM" (for coiled-coil 3-helix micelles). At only 20 nm in size, and featuring a unique hierarchical structure, these new nanocarriers meet all the size and stability requirements for effectively delivering therapeutic drugs to GBM tumors. Their smaller size and unique hierarchical structure afford the 3HM nanocarriers much greater access to rat GBM tumors than larger-sized devices including the liposomes (of 110 nm in size). Copper-64 is used to label both 3HM and liposome nanocarriers for systematic PET and MRI studies to find out how a nanocarrier's size might affect the pharmacokinetics and biodistribution in rats with GBM tumors. The results not only confirmed the effectiveness of 3HM as GBM delivery vessels, they also suggest that PET and MRI imaging of NP distribution and tumor kinetics can be used to improve the future design of NPs for GBM treatment.
Micelles are spherical aggregates of ampiphiles (chemical compounds that feature both hydrophilic and lipophilic properties). They can cross the BBB and accumulate inside GBM tumors at nearly double the concentration rate of current FDAapproved nanocarriers. (Figure 8). They have shown very good attributes for the treatment of brain cancers in terms of long circulation, deep tumor penetration and low accumulation in off-target organs such as the liver and spleen. There also is the possibility that they can be administered intravenously rather than invasively.
Future Prospects and Conclusions
NT will reduce the need for invasive surgery although some devices (implanted catheters and reservoirs) will likely still be needed. Nanomaterials improve the safety/efficacy of NDs. Nanoengineered probes can deliver drugs at the cellular level using nanofluidic channels. Microchips and biodegradable polymeric NP carriers may be more effective therapeutically for brain tumors. Next-generations include H3M micelles, nanoparticle nasal spray, and "sticky" NPs. However, while great advances have been made in developing effective drugs for other types of cancer, we still do not fully understand the deep biology of glioblastomas and have not come up with the corresponding drugs. In the meantime, GBMs continue to progress rapidly in their ineluctable death path. We should dedicate considerably more time on understanding that deep biology!
- Fymat AL (2017a) Surgical and non-surgical management and treatment of glioblastoma: I. Primary tumors. Open Access J of Surgery 7(2): 1-8.
- Fymat AL (2017b) Surgical and non-surgical management and treatment of glioblastoma: II. Recurring tumors. Open Access J of Surgery 7(1): 1-7.
- Fymat AL (2017c) Glioblastoma treatments: Where do we stand? Med Plus J of Cancer & Oncology Research 1(1): 1-12.
- Stolp HB, Liddelow SA, Sá-Pereira I, Dziegielewska KM, Saunders NR (2013) Immune Responses at Brain Barriers and Implications for Brain Development and Neurological Function in Later Life. Front Integr Neurosci 7: 61.
- Scherrmann JM (2002) Drug delivery to brain via the blood-brain barrier. Vascul Pharmacol 38(6): 349-354.
- Temsamani J, Rousselle C, Reese AR, Scherrmann JM (2001) Vectormediated drug delivery to the brain. Expert Opin Biol Ther 1(5): 773- 782.
- Fymat AL (2018) Nanobiotechnology Advances in Oncology. Advances in Bioengineering & Biomedical Science Research 1(1): 1-6.
- Bose RJ, Lee SH, Park H (2016) Lipid-Based Surface Engineering of PLGA Nanoparticles for Drug and Gene Delivery Applications. Biomater Res 20: 34.
- Ashton (2016) Accurin Nanoparticles Dutifully Deliver Drugs. Science Translational Medicine 8(325).
- Fymat AL (2017d) Nanomedicine as a precursor to precision medicine for glioblastoma treatment. J of Current Opinions on Neurological Science 1(4): 200-206.


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While there are many ways to cut your costs while trying to eat healthy on a budget, the five steps mentioned should be able to get you started on a better, more hopeful path to cutting your costs and sticking to a healthy lifestyle. With a little effort, organization and creativity, you no longer have any excuses why you cannot save money and also look and feel at your best.

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Niacin, also known as nicotinic acid, is an organic compound and is, depending on the definition used, one of the 20 to 80 essential human nutrients. Together with nicotinamide it makes up the group known as vitamin B3 complex. It has the formula C6H5NO2 and belongs to the group of the pyridinecarboxylic acids.
In global market, the sales of Nicotinamide increased from 55407 MT in 2013 to 76862 MT in 2017. In 2017, the global Nicotinamide market is led by Europe, capturing about 31.97% of global Nicotinamide consumption. China is the second-largest region-wise market with 28.81% global consumption share. The global Nicotinamide (NAA) (aka Niacinamide) market is valued at USD 605.04 million in 2017 and is expected to reach USD 724.10 million by the end of 2024, growing at a CAGR of 2.60% between 2017 and 2024.
At present, the major manufacturers of Nicotinamide are concentrated in Lonza, Jubilant Life Sciences, Vertellus, Brother Enterprises, Zhejiang Lanbo Biotechnology, Lasons India, Vanetta, DSM and Tianjin Zhongrui Pharmaceutical. Lonza is the world leader, holding 45.79% consumption market share in 2017. Lonza's main markets are China and Europe. Vertellus is the only producer in the United States. At present, Vertellus Europe's production capacity has been transferred to China. In 2014, Lonza built a new 15,000 production line in China. At the same time, Lonza shut down the oldest production line (5000 tons production line in 1995) due to environmental stress. At present, Lonza has 25,000 tons production capacity in China (10000 tons production line in 2005 and 15,000 tons production line in 2014).
The global Nicotinamide (NAA) (aka Niacinamide) market was 610 million US$ in 2018 and is expected to 760 million US$ by the end of 2025, growing at a CAGR of 3.3% between 2019 and 2025.
This report studies the Nicotinamide (NAA) (aka Niacinamide) market size (value and volume) by players, regions, product types and end industries, history data 2014-2018 and forecast data 2019-2025; This report also studies the global market competition landscape, market drivers and trends, opportunities and challenges, risks and entry barriers, sales channels, distributors and Porter's Five Forces Analysis.
Geographically, this report is segmented into several key regions, with sales, revenue, market share and growth Rate of Nicotinamide (NAA) (aka Niacinamide) in these regions, from 2014 to 2025, covering
North America (United States, Canada and Mexico)
Europe (Germany, UK, France, Italy, Russia and Turkey etc.)
Asia-Pacific (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Malaysia and Vietnam)
South America (Brazil etc.)
Middle East and Africa (Egypt and GCC Countries)
The various contributors involved in the value chain of the product include manufacturers, suppliers, distributors, intermediaries, and customers. The key manufacturers in this market include
Jubilant Life Sciences
Brother Enterprises
Zhejiang Lanbo Biotechnology
Lasons India
By the product type, the market is primarily split into
Pharmaceutical Grade
Feed Grade
By the end users/application, this report covers the following segments
Feed Additives
Food and Drinks Industry
Pharmaceutical Industry
Daily Chemicals
We can also provide the customized separate regional or country-level reports, for the following regions:
North America
United States
South Korea
Rest of Asia-Pacific
Rest of Europe
Central & South America
Rest of Central & South America
Middle East & Africa
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South Africa
Rest of Middle East & Africa
The study objectives of this report are:
To study and analyze the global Nicotinamide (NAA) (aka Niacinamide) market size (value & volume) by company, key regions/countries, products and application, history data from 2014 to 2018, and forecast to 2025.
To understand the structure of Nicotinamide (NAA) (aka Niacinamide) market by identifying its various subsegments.
To share detailed information about the key factors influencing the growth of the market (growth potential, opportunities, drivers, industry-specific challenges and risks).
Focuses on the key global Nicotinamide (NAA) (aka Niacinamide) manufacturers, to define, describe and analyze the sales volume, value, market share, market competition landscape, SWOT analysis and development plans in next few years.
To analyze the Nicotinamide (NAA) (aka Niacinamide) with respect to individual growth trends, future prospects, and their contribution to the total market.
To project the value and volume of Nicotinamide (NAA) (aka Niacinamide) submarkets, with respect to key regions (along with their respective key countries).
To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market.
To strategically profile the key players and comprehensively analyze their growth strategies.
In this study, the years considered to estimate the market size of Nicotinamide (NAA) (aka Niacinamide) are as follows:
History Year: 2014-2018
Base Year: 2018
Estimated Year: 2019
Forecast Year 2019 to 2025
This report includes the estimation of market size for value (million USD) and volume (K MT). Both top-down and bottom-up approaches have been used to estimate and validate the market size of Nicotinamide (NAA) (aka Niacinamide) market, to estimate the size of various other dependent submarkets in the overall market. Key players in the market have been identified through secondary research, and their market shares have been determined through primary and secondary research. All percentage shares, splits, and breakdowns have been determined using secondary sources and verified primary sources.
For the data information by region, company, type and application, 2018 is considered as the base year. Whenever data information was unavailable for the base year, the prior year has been considered.
Key Stakeholders
Raw material suppliers
Regulatory bodies, including government agencies and NGO
Commercial research & development (R&D) institutions
Importers and exporters
Government organizations, research organizations, and consulting firms
Trade associations and industry bodies
End-use industries
Available Customizations
With the given market data, QYResearch offers customizations according to the company's specific needs. The following customization options are available for the report:
Further breakdown of Nicotinamide (NAA) (aka Niacinamide) market on basis of the key contributing countries.
Detailed analysis and profiling of additional market players.


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Expression of Interest for construction of model school in Beledweyn Hiiran region – Hirshabelle Regional Adminstrtion of Somalia
- Anywhere
- Contract/Consultancy
- Job category: Tender/Bid/RFQ/RFP
- Post date:22 Aug 2019
- Share job:
Job Description
Expression of Interest for construction of model school in Beledweyn Hiiran region – Hirshabelle Regional Adminstrtion of Somalia.
Relief International (RI) is a leading non-profit organization working in 20 countries to relieve poverty, ensure well-being and advance dignity. We specialize in fragile settings, responding to natural disasters, humanitarian crises and chronic poverty. Relief International combines humanitarian and development approaches to provide immediate services while laying the groundwork for long-term impact. Our signature approach — which we call the RI Way—emphasizes local participation, an integration of services, strategic partnerships, and a focus on civic skills. In this way, we empower communities to find, design and implement the solutions that work best for them.
Relief International (RI) in South Central, Somalia is inviting submissions of tender for below tender for construction of model school in Hiran – Beledweyne Somalia.
|Expression of Interest for construction of model school in Beledweyne,
|Hiran – Hirshabelle state of Somalia
Submission details:
Interested and reputable companies who intend to provide the required service need to meet the requirements listed below:
- Registration certificate: Valid relevant registration Reginal Governor/ministry of Publice work from relevant Hirshabelle administration.
- Phsical Presence : Operational Offices and presence in Beledweyne with functional Teams (enginer and finance) is Mandatory. Other Offices in Somalia is additional
- Experience: School Construction relevant experience over the last 2 to 3 years. Attach the copy of the contracts.
- Capital Assets: Possess construction materials and equipments such as mixers and other construction tools.
- Companies Bank statement: from 1st June 2018 up to 31st August 2019
- Updated company profile with organogram, List of CVs of the engineers and finance teams
Interested companies are advised to collect a complete set of bid documents and instructions at RI Mogadishu office or RI Beledweyne Office between 9:00AM to 4:0PM from 22nd August to 14th September, 2019.
Sealed bid documents MUST be returned to RI Beledweyne Office or RI Mogadishu Office in a sealed envelope clearly stating the reference number, company name and its contact address not later than 4:00PM on 14th Sept 2019
For any query, please address via mail through: email@example.com
Late bids shall be rejected and no liability will be accepted for loss, late delivery or non-delivery, whatsoever. Bids shall be opened at a later date to be communicated.
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One of the pillars of Donald Trump's candidacy and presidency is the pursuit of what he refers to as "immigration reform." The very term is consistent with, and evocative of his authoritarian frame and the metaphors associated with it - implying that immigrants pose a problem which requires "reform." Why are the words, phrases, and actions by conservatives/Republicans so effective at making people feel afraid and insecure? And how best to vanquish the bogeyman?
To know how to change public discourse, it's important to understand why Republicans have been so successful. Most importantly, conservatives and Republicans have been very effective at making their ideas, or frames, dominant. So dominant in fact, that progressives and Democrats have no plan, no strategy that counters their cognitive dominance. Ironically, the political party that claims to follow science fails to do so in its messaging and communication efforts! A recent article in The Guardian science section explains the importance of framing in our politics - it's a spot on read.
Back to the immigration issue. An article from July 18 in Breitbart (reading and following conservative news sites is critical to understanding their frames, metaphors, and messages) provides us with important insights as to why their message is so consistent with their frame, and therefore so successful.
For those of you who have an understanding of the conservative moral frame, this will be a review, but it is important background. The conservative moral worldview (frame) is based on an authoritarian hierarchy. This hierarchy is consistent with their values of self-discipline, success (from discipline), and who ought to have authority based on who is the most prosperous - and therefore worthy and moral. The conservative frame puts God over man, Christians over non-Christians, man over nature, men over women, and people from the US over people from all other nations. It is the cognitive foundation for radical nationalism (along with a host of other prejudices). The Breitbart article makes this very clear from the first paragraph:
"A Washington Post survey of established economists shows growing support for President Donald Trump's planned merit-based immigration reform to boost Americans' productivity and wealth."
I've highlighted the critically important framing language. For the average American, whether the economic facts stated are true are secondary - it is the metaphors and frames that influence people!
"Merit-based immigration reform" is a conservative metaphor which means that only people who are deserving will be allowed to immigrate; as opposed to current policy which has created a problem in need of reform. Similar ideas and metaphors are found throughout the article.
The phrase "boost Americans' productivity and wealth" is an idea consistent with "Make America Great Again." When these necessary reforms are in place, people like you will be free to be more productive, and more wealthy. More importantly, putting the two phrases together has the cognitive effect of placing blame for America's economic woes squarely on immigrants - since their hierarchy places them morally beneath Americans. Any messaging of immigration in the context of economic growth also evokes the conservative frame, as "The Market" is a moral system where success = morality. So the promise to relieve America of this "immigration problem" is very powerful! Fortunately, cognitive science and framing can help us vanquish the bogeyman.
One world leader who consistently evokes empathy (progressive frame) across a host of issues, especially immigration, is Canada PM Justin Trudeau. Of course, he's not perfect, but he's a far cry better than our national leader. This video from 2015 provides us with a great example:
If we are to change public perception and political discourse about immigration, there is a critical need to act and talk in a way that authentically conveys empathy, a moral caring for others, repeatedly and consistently.
Notice the empathy and connections with people Trudeau evokes by his actions AND words. Especially here:
"How you receive these people tonight will be something they will remember for the rest of their lives; but also something YOU will remember for the rest of YOUR life...tonight matters NOT JUST FOR CANADA, BUT FOR THE WORLD."
Trudeau's statement connects people by evoking empathy - the good feeling the immigrants will get from their reception will be mirrored by those helping them. This is a powerful cognitive statement, since we are all hard-wired for empathy!
How we care for others, and express those values in word and deed are critically important to overcoming fear. After all, we know for a fact that hope will overcome fear every time. Providing people with a message that immigrants provide us with a hopeful future; and that caring for others will bring us together and make us stronger as a people can go a long way towards vanquishing the bogeyman. Connecting people through those values is the place to start.
In tomorrow's Daily Dose - How do we talk to Trump supporters?


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An act to consolidate and amend the law relating to steam boilers to ensure the safety in its manufacture and use. The connected regulations and rules enforced: i. The Indian Boiler regulation 1950 . ii. The Karnataka Boiler Rules 1982 . iii. The Karnataka Economisers Rules 1959 . iv.Learn More
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miniature boilers; high temperature water boilers, heat recovery steam generators, and certain fired pressure vessels to be used in stationary service; and power boilers used in locomotive, portable, and traction service. Rules pertaining to use of the single ASME certification mark with the V, A, M, PP, S, and E designators are also included. New!Learn More
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Karen and Jon had their wedding at the gorgeous Greek Orthodox Cathedral with a fun-filled reception at the ColumbusView full post »
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reception : Scioto Country Club
planner : Meleka Jolliff – MMJ Events
dress : Jenny PackhamView full post »
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church : Bexley United Methodist Church
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caterer : CameronView full post »
We are so excited that Alicia and Dan's NYE Downtown Hilton wedding is featured on Style Me PrettyView full post »
Alicia and Dan's Stylish and fun New Year's Eve wedding celebration at the Hilton DowntownView full post »
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Osaka, Sept. 30 (Jiji Press)--Kansai Electric Power Co. <9503> said Monday that it will hold another press conference, on Wednesday, over a money scandal involving its nuclear plant business in the town of Takahama, Fukui Prefecture, central Japan.
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We will also be open all weekend, including Sunday, in case you can't make it for Friday and Saturday (or in case, Alanis Morissette needs say, a dress, or anything else of the sort!).
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{DID YOU KNOW: "The Cult" frontman Ian Astbury is not only a mens style icon, and one of the greatest rock musicians of all time, but he also was a resident of Hamilton, Ontario, from 1973 – 1978! }
Until we meet again,
+ + {theEye} + +
Man with Knife: You're a very nosy fellow, kitty cat. Huh? You know what happens to nosy fellows? Huh? No? Wanna guess? Huh? No? Okay. They lose their noses . . .
The scene almost comes out of nowhere, but its an integral piece of the puzzle in what is arguably one of the best films ever made.
Roman Polanski's 1974 classic "Chinatown" was written by Robert Towne (who won the film's sole Academy Award for Original Screenplay) and starred Faye Dunaway and the never better Jack Nicholson in a poignant reconception of the classic film noir that took the genre from the dark wet streets of the cold bitter city to the overheated dry spell of a Los Angeles bathed in tones of gold, cream, and pastel hues.
There had never been a hero before or since who spent most as much screen time with an obtrusive bandage covering his face, and yet still just be as dapper.
For the film, legendary costume designer, Anthea Sylbert, designed and crafted most of the pieces from scratch to ensure the perfect fit and tonality with the film's washed-out summery palette. For Dunaway's character, Sylbert took inspiration from classic noirs such as "Double Indemnity" and "Mildred Pierce", but it is truly the stunning menswear for Jake Gittes who receives most of the love in the wardrobe department (which is very very rare, and much appreciated on our part).
Indeed, Sylbert has chosen only the finest materials to work with in crafting clothes for Jake. Three-piece suits made of quality wools, silks, and linens with wide lapels indicative of the period (1937). Best of all, you will never find him in your run of the mill suit – it always has some brilliant colour story to it, and with the summer heat, Jake isn't afraid to embrace lighter colours (camel, khaki, sage – you should follow suit).
And what would a three-piece suit be without a crisp, clean, and modern fedora? Jake definitely has some serious style in spades.
While watching the film, keep an eye out for impressive pocket square and necktie combinations. It's a great way to pick up a few tips and garner a little inspiration. Don't be afraid of pattern, and aim to stand out from the crowd.
There must be over a dozen separate looks over the span of the film, but that's just the kind of guy Jake Gittes is. He knows the power of style, and what it means to dress to impress. After all, it's much easier to go where you need, and get what you want, like that.
So let's take a few pointers, and look at why almost 40 years later, "Chinatown" is the ultimate go-to for vintage style inspiration this summer!
Jake: Son of a bitch! Goddamn Florsheim shoe . . .
Forever and always a favourite, add "Chinatown" to your list of films to watch this summer! Also, don't forget to check out the {SHOP} for all the amazing finds, because we have just what it takes to be as stylin' as Jake Gittes, himself. I definitely think he'd approve . . .
Don't forget it – it's "Chinatown" . . .
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KFC Singapore eradicates plastic cups and reduces paper packaging waste
KFC Singapore is ditching plastic cups entirely in favour of paper cups in its 85 restaurants island wide.
Paper cups manufactured out of food-grade paper will replace the brand's regular plastic cups, cutting 8.3g of plastic from a regular-sized cup and 10g from a medium-sized cup. KFC expects the move to see a decrease in consumption of single use plastic cups by almost 500,000 units, or approximately 4.25 metric tonnes of plastic waste per month.
"As a brand that cares, KFC Singapore is dedicated to packaging innovation as part of our ongoing initiative to reduce single-use plastics and most importantly, waste," said Kentucky Fried Chicken Management GM Lynette Lee. "We are proud to have kick-started a nation-wide movement against single-use plastic straws last year. Next, on our continuous drive towards environmental sustainability, KFC Singapore is replacing plastic cups with paper cups this year,"
KFC Singapore has approached sustainable practices via removal of non-recyclable packaging and reduction of paper packaging waste.
In alignment with the National Environment Agency's aim to reduce waste, KFC Singapore will be introducing new reusable trays to further cut paper packaging waste on 13 dine-in menu items in its next phase. This initiative will be first put on trial in KFC Kallang and Toa Payoh this December.


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What are the high temperature resistant resins?
In the aerospace industry, in order to maximize the limited carrying capacity, the weight control of each component is very strict. Resin-based composites are increasingly being used in this field due to their excellent overall properties. In addition to the very high requirements for the mechanical properties of the material, there are also high requirements for temperature resistance. The following Xiaji network Xiaobian introduces several common high temperature resistant resins.
Polyimide (PI)
Polyimide, English name Polyimide (referred to as PI), a type of polymer containing an imide ring (-CO-NH-CO-) in the main chain. It is one of the best organic polymer materials with high comprehensive performance, high temperature resistance up to 400 °C, long-term use temperature range -200-300 °C, no obvious melting point, high insulation performance, dielectric constant of 103 Hz, dielectric loss Only 0.004 - 0.007, belonging to F to H.
According to the chemical structure of the repeating unit, the polyimide can be classified into three types: aliphatic, semi-aromatic, and aromatic polyimide. According to thermal properties, it can be divided into thermoplastic and thermosetting polyimides.
Polytetrafluoroethylene (PTFE)
Polytetrafluoroethylene, the English name is Poly tetra fluoroethylene, abbreviated as PTFE. If you don't know much about this resin, you can be very familiar with the alias Teflon and Teflon. That's right, it's the coating that's commonly used on non-stick pans.
What are the high temperature resistant resins?
This material is resistant to acids and bases and to various organic solvents and is almost insoluble in all solvents. At the same time, PTFE has the characteristics of high temperature resistance, and its friction coefficient is extremely low, so it can be used as a lubricant and it is also an ideal coating for easy cleaning of the inner layer of water pipes.
It has a melting point of up to 327 ° C and its long-term stability is stable from -180 to 250 ° C.
Polyphenylene ether (PPO/PPE)
Polyphenylene ether is a high-strength engineering plastic developed in the 1960s. Its chemical name is poly(2,6-dimethyl-1,4-phenylene ether), or PPO (Polyphenylene Oxide) or PPE (Polypheylene ether). It is a polyphenylene oxide or a polyphenylene ether.
It has high heat resistance, glass transition temperature of 211 ° C, melting point of 268 ° C, heating to 330 ° C has a tendency to decompose, the higher the content of PPO, the better the heat resistance, the heat distortion temperature can reach 190 ° C.
PPO is non-toxic, transparent, and relatively low in density, and has excellent mechanical strength, stress relaxation resistance, creep resistance, heat resistance, water resistance, water vapor resistance, and dimensional stability. It has good electrical properties in a wide range of temperature and frequency. The main disadvantages are poor melt flow and difficult processing. Most of the practical applications are MPPO (PPO blends or alloys). For example, PS modified PPO can greatly improve the processing performance. Improves stress crack resistance and impact resistance, reduces cost, and only slightly reduces heat resistance and gloss.
Polyphenylene sulfide (PPS)
Polyphenylene sulfide is a polyphenylene sulfide, a thermoplastic resin with a phenylthio group in the main chain of the molecule, abbreviated as PPS in English. Polyphenylene sulfide is a crystalline polymer.
The undrawn fiber has a large amorphous region (crystallinity of about 5%), and an crystallization exotherm occurs at 125 ° C, the glass transition temperature is 150 ° C; and the melting point is 281 ° C. The drawn fiber produces partial crystallization during the stretching process (increased to 30%), and heat treatment of the drawn fiber at a temperature of 130-230 ° C can increase the crystallinity to 60-80%. Therefore, the drawn fiber has no significant glass transition or crystallization exotherm and has a melting point of 284 °C.
As the crystallinity increases after stretching heat setting, the density of the fiber increases correspondingly, from 1.33 g/cm? before stretching to 1.34 g/cm? after stretching, and up to 1.38 g after heat treatment. Cm?. Molding shrinkage: 0.7% Molding temperature: 300-330 °C.
The heat distortion temperature is generally greater than 260 degrees and can be used in the temperature range of 180-220 ° C. PPS is one of the best heat-resistant varieties in engineering plastics.
Polyetheretherketone (PEEK)
Polyetheretherketone (English poly-ether-ether-ketone, PEEK for short) is a high polymer composed of a repeating unit containing a ketone bond and two ether bonds in the main chain structure, and is a special polymer material. It has a physicochemical property such as high temperature resistance and chemical corrosion resistance. It is a kind of semi-crystalline polymer material with melting point of 334 ° C, softening point of 168 ° C and tensile strength of 132-148 MPa. It can be used as high temperature resistant structural material and electrical insulating material. , can be combined with glass fiber or carbon fiber to prepare reinforcement materials. A type of polyarylene ether polymer obtained by condensation with an aromatic dihydric phenol is generally used.
PEEK has excellent heat resistance and high temperature resistance. It can be used for a long time at 250 °C. The instantaneous temperature can reach 300 °C. It has high rigidity, dimensional stability and small coefficient of linear expansion. It is close to metal aluminum. PEEK has good chemical stability. It has strong corrosion resistance to acid, alkali and almost all organic solvents, and has the properties of flame retardant and radiation resistance. PEEK has excellent resistance to sliding wear and fretting wear, especially at 250 ° C. High wear resistance and low friction factor; in addition, PEEK is easy to extrude and injection molding.
Bismaleimide (BMI)
Bismaleimide (BMI) is another type of resin system derived from polyimide resin system. It is a bifunctional compound with maleimide (MI) as the active end group. Similar fluidity and moldability can be processed by the same general method as epoxy resin, which overcomes the shortcomings of relatively low heat resistance of epoxy resin. Therefore, it has been rapidly developed and widely used in the past two decades. .
BMI has excellent heat resistance due to its high benzene ring, imide heterocyclic ring and high crosslink density. Its Tg is generally greater than 250 ° C, and the temperature range is from 177 ° C to 232 ° C. Ethylenediamine in the aliphatic BMI is the most stable, and the thermal decomposition temperature (Td) will decrease as the number of methylene groups increases. The Td of aromatic BMI is generally higher than that of aliphatic BMI, and the Td of 2,4. diaminobenzene is higher than other types. In addition, Td has a close relationship with the crosslink density, and Td increases with the increase of crosslink density within a certain range.
Furan resin
Furan resin is a general term for resins produced from sterols and furfurals with furan rings as raw materials. It cures to insoluble and infusible solids under the action of strong acids. The types are sterol resins, furfural resins, fluorenone resins, fluorenone- Formaldehyde resin, etc.
The heat-resistant material furan glass fiber reinforced composite material has higher heat resistance than the general phenolic glass fiber reinforced composite material, and can be used for a long time at around 150 °C.
Cyanate resin (CE)
Cyanate resin is a new type of thermosetting resin with two or more cyanate functional groups (-OCN) in the molecular structure developed in the 1960s. Its molecular structure is: NCO-R-OCN; The cyanate resin is also called triazine A resin, and the full name of the English is Triazine A resin, TA resin, Cyanate resin, abbreviated as CE.
Cyanate ester CE has excellent high temperature mechanical properties, higher bending strength and tensile strength than bifunctional epoxy resin; very low water absorption (<1.5%); low molding shrinkage, good dimensional stability; heat resistance Well, the glass transition temperature is 240-260 ° C, the highest can reach 400 ° C, the modification can be cured at 170 ° C; the heat and humidity resistance, flame retardancy, adhesion are very good, and glass fiber, carbon fiber, quartz fiber Reinforcing materials such as whiskers have good bonding properties; excellent electrical properties, extremely low dielectric constant (2.8 - 3.2) and dielectric loss tangent (0.002 - 0.008), and dielectric properties versus temperature and The change in the frequency of the electromagnetic wave shows a characteristic stability (i.e., has a wide band).
Polyarylethynyl (PAA)
Polyarylethynyl (PAA) resins are a class of high performance polymers formed by addition polymerization of ethynyl aromatic hydrocarbons. It is an ideal material for fiber-reinforced ablation-resistant high-carbon resin, and is widely used in aerospace materials such as rocket nozzles and missile engine nozzles.
The above is the introduction of high temperature resistant resin. The so-called high temperature is relatively speaking. In general, the temperature resistance of resin-based composite materials is slightly inferior to composite materials such as metal-based and ceramic-based materials. However, the greatest attraction of composite materials lies in their designability. Through reasonable design and molding process, they can develop their strengths and avoid weaknesses.


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Lunch at St John today. A special time with Francis Percival, Dan Keeling and Jeremy Seysses. The company, the wines, the food: all were on sparkling form. I haven't been to St John in a while. I will be back soon, for sure. Highlights included a wonderful crispy pig skin salad, and decadently rich devilled kidneys.
Bérêche et fils Les Beaux Regards Chardonnay 2010 Champagne, France
Disgorged January 2014. Lovely precision here: fine and toasty with lively lemony fruit and subtle creamy notes. Some toastiness in the background, as well as a bit of spice. Really refined. 94/100
Niero Côte Rôtie 1999 Northern Rhône, France
Soft, perfumed and quite elegant with lovely red cherry and pepper notes as well as subtle earthiness and an agreeable maturity. An elegant style that's now drinking perfectly. 93/100
Ghislaine Barthod Chambolle-Musigny 1er Cru Les Charmes 1993 Burgundy, France
Fresh and a bit bloody with nice finesse to the bright red cherry and plum fruit, offset with some peppery spiciness. Lovely purity and direction here with precision to the fruit. Beautiful. 95/100
Domaine Dujac Clos de la Roche 1993 Burgundy, France
Thrilling: pure, sanguine, with some savoury iodine notes and elegant, mature black cherry and plum fruit with some citrus characters. Lovely herb and spice notes. So fine and expressive with finesse and elegance, and in a really good place for current drinking. 95/100
Find these wines with wine-searcher.comLeave a Comment on Lunch at St John with Dujac, Niero, Barthod and Bereche


text: Every employee is important to the lasting success of your organization, but executives certainly play the largest role. It's important to be very thorough when searching for someone to fill an open positon on your company leadership team. You can never be too careful when choosing a candidate to shape the future of your organization,… Read more »


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Footwear Recommendations It Is Advisable To Read
Getting a great pair of shoes can sometimes be an excellent obstacle. With so many variations and manufacturers in the marketplace, it can occasionally be mind-boggling. You only need some really good advice to help you make a sensible footwear option determination. These write-up will reveal how to make your sneaker buying experience a pleasurable one particular.
View your spending budget. When you just have a great deal dollars to pay on shoes, then only invest that amount. Sometimes, sales can make you believe available a whole bunch of footwear that you simply didn't want to purchase, and you can quickly talk about price range carrying it out. Just purchase what you require and stay under price range.
Your feet are worthy of a comfortable set of footwear. Your footwear and feet are common essential. Sporting uneasy boots only for their appears can actually hurt your toes over time. Sickly installing shoes or boots can damage your toes.
When you are buying shoes with your kids, their very own toes calculated. Children's toes can grow very quickly and must be calculated one or more times each and every 3 months. Take into account that your children will likely rapidly outgrow the footwear you buy them when determining within a strict budget for the children's footwear.
Consider getting into prize draws at community sneaker retailers. Simply by entering only smaller sized contests, your chances are better at winning. If you wind up winning a present credit card or footwear, it will save you a huge amount of dollars. Even if you don't win, at least you'll have some fun coming into the contests!
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You must move close to in a set of shoes or boots prior to getting. Go on a stroll across the retail store just to ensure that they think excellent on your ft although wandering and not simply when you're sitting yourself down. Once you walk, your feet will really feel any irregular rubbing. You save a ton of money by staying away from boots that do not in shape effectively.
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Shoes or boots that you just acquire should always remain in your dimension. Even if you get a set of boots that you just have to have, usually do not purchase them unless they are your size. Few things appearance as difficult like a girl travelling in shoes or boots which can be extremely uneasy.
Look for shoes late inside the working day. As being the working day would wear on, the feet enlarge a little. Plan your following sneaker store shopping getaway to the night. This will assist to ensure your footwear is comfortable always during the day.
Sign up for the internet email list associated with a shoes retailer you love. Clients often receive coupons, notice about approaching sales or specific information about new arrivals well before the details are placed to their site. You may even instantly be put into competitions by merely being registered for that eNewsletter!
Be sure that when you're getting boots on-line that you find out if the vendor is effectively analyzed. More often than not on a website, you will see a place in which individuals can discuss the support they obtained. Focus on these remarks so that you don't end up getting inadequate services.
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The latest research report on 4K Ultra HD TVs market for the forecast period, 2019- 2026 is involved in screening the business environment and the companies operating in the 4K Ultra HD TVs industry. Importantly, the research sheds a lot of light on their winning strategies to help stakeholders, business owners, and field marketing executives stay ahead in the competition. Besides, the industry is thoroughly weighed upon on the basis of the total revenue generated as well as the output/volume produced year after year. Other aspects including but not limited to the market drivers, key opportunities and probable restraints are thoroughly assessed during the study.
The study has been conducted on the basis of inputs from the industry leaders. Thus, a conscious effort to dive deep and unearth hard to find information pertaining to the growing market landscape and growth prospects over the next few years is clearly visible in the study. The market intelligence report further comprises of discussions about the major vendors operating in the 4K Ultra HD TVs space.
The global market size of 4K Ultra HD TVs is $XX million in 2019 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million by the end of 2026 with a CAGR of XX% from 2019 to 2026.
Request For Free Sample Copy of 4K Ultra HD TVs market report @ https://www.marketexpertz.com/sample-enquiry-form/12254
Major Players in 4K Ultra HD TVs market are:
- Samsung
- Haier
- Sharp
- Panasonic
- Skyworth
Scope of the Report:
The 4K Ultra HD TVs market is further segmented in terms of applications, end-user, end-use, geographic presence, by-products as well as services. In addition, the subject matter experts evaluating the industry provide an all-inclusive category-specific industry outlook. A comprehensive collection of data on major companies occupying a strong foothold in the industry adds immense value to the overall research. The assessment of the wining strategies followed by these companies can help business owners not only strategize but also execute business operations by referring the statistics about competitor analysis. Careful assessment of the industry analysis across different regions along with vital information on the market size, share and growth rate makes this report a wonderful resource for business evangelists.
Most important types of 4K Ultra HD TVs products covered in this report are:
- <55 Inch
- 55 Inch
- 65 Inch
- Others
Most important applications of 4K Ultra HD TVs market covered in this report are:
- Household
- Public
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In market segmentation by geographical regions, the report has analysed the following regions-
- North America
- China
- Europe
- Southeast Asia
- Japan
- India
Understanding the market size:
The size of the 4K Ultra HD TVs market is viewed in terms of the Share of Market, Total Available Market as well as Served Available Market. Not only does the study present the combined revenue for a particular market but also the market size for a specific geographic region. Analysis of percentage or the size of the Total Available Market based on the type of product, technology, regional constraints and others form an important part of the 4K Ultra HD TVs report.
Read more @ https://www.marketexpertz.com/industry-overview/4k-ultra-hd-tvs-market