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Introduction. Digestive System. Physiology. Anatomy. Physiology. Alimentary Canal. Chapter 21
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1 Chapter 21 Digestive System Susan G. Salvo Introduction Digestive process is a disassembly line Digestive system provides processes in which proteins, carbohydrates, and fats are broken down and used a fuel Fuel carried to rest of body by circulatory system Parasympathetic nervous system initiates digestive functions during periods of low stress 1 2 Anatomy Physiology Alimentary canal (tube from mouth to anus) Gallbladder Liver Pancreas Salivary glands Teeth Tongue Ingestion orally taking materials into the body Digestion processes that make food absorbable Mechanical digestion chewing, stomach churning, and movements in intestinal tube (peristalsis) Chemical digestion enzymes break food down further 3 4 Physiology Alimentary Canal Absorption products of digestion move into bloodstream or lymph vessels and then body s cells Defecation eliminating indigestible or unabsorbed material from the body Also called the GI tract Coiled, muscular passageway leading from mouth to anus; mostly smooth muscle Peristalsis tonic and rhythmic contractions that help mix and propel food through GI tract Bolus lump/ball of food that has been chewed, mixed with saliva, and swallowed 5 6 1
2 Alimentary Canal Oral Cavity (Mouth) Peritoneum Envelops abdominal wall Largest serous membrane Houses blood and lymph vessels, and nerves Port of entry for food and drink Includes tongue, teeth, gums, and openings from salivary ducts Mastication chewing Deglutition swallowing Salivary amylase, an enzyme, begins carbohydrate digestion Gustatory organs (taste buds) chemoreceptors that detect sweet, sour, bitter, and salty tastes 7 8 Pharynx Esophagus Also known as the throat Tube structure that transports food, liquid, and air to their respective destinations In digestion, pharynx takes food from oral cavity to esophagus during swallowing Muscular tube that connects pharynx to stomach Esophageal lining secretes mucus to aid in transport of food Esophagus bypasses thoracic organs and pierces the diaphragm to transport food to stomach 9 10 Stomach Stomach J-shaped organ that is an enlargement of the GI tract, bound at each end by sphincters Cardioesophageal sphincter junction between esophagus and stomach Pyloric sphincter junction between stomach and small intestine When empty, size of a large sausage When full, can hold up to 1 gallon of food Rugae longitudinal folds in lining of stomach that permit expansion Chyme bolus reduced to thin, viscous fluid as food travels through stomach to small intestine Water, some minerals, alcohol, and some medications are the only substances absorbed by stomach lining
3 Parietal cells secrete intrinsic (B12 absorption) and hydrochloric acid (breaks down proteins and activates enzymes) Chief cells secrete pepsinogen, a precursor to pepsin (protein digestion) Stomach 13 Small Intestine Longest section of the alimentary canal Bound at both ends by sphincters: Pyloric sphincter between stomach and small intestine Ileocecal sphincter between small intestine and large intestine at the cecum Small intestine responsible for 90% of all absorption 14 Small Intestine Small Intestinal Wall Divisions of small intestine in order: duodenum, jejunum, and Ileum Villi: fingerlike projections housing blood and lymph capillaries Plicae circulares: circular folds within lumen Mesenteries: sections of the peritoneum that connect divisions of small intestines to abdominal wall Greater and lesser omentums Absorption Sites in Digestive Tract Large Intestine (Colon) Lining produces a mucus that helps undigested matter move through Colon absorbs large amounts of water and some vitamins and minerals Characterized by two structures: Taenia coli resemble thread-gathering fabric Haustra pouches formed by tucks made by taenia coli along length of colon
4 Large Intestine (Colon) Accessory Digestive Organs Divisions of large intestine: Cecum saclike structure in lower right abdomen and is first section Vermiform appendix lymph gland suspended from the cecum Ascending, transverse, and descending (proper) colons move clockwise Rectum main function is storage Anal canal also stores fecal matter Anus terminus of anal canal Liver produces bile (fat emulsifier) Gallbladder stores bile Pancreas secretes enzymes that acts on proteins, carbs, and fats Exocrine Cells of the Pancreas Large Intestine (Colon) Proteins organic compounds that contain large combinations of amino acids 10 amino acids are non-essential (can be synthesized by body); 8 amino acids are essential (must be ingested) Carbohydrates body s preferred source of energy Required for metabolism of other nutrients Absorption mediated by insulin Fats composed of lipids or fatty acids; can range in consistency from solid to liquid Saturated fats lard, processed oils; are solid at room temperature Unsaturated fats olive, peanut, flax seed, and sesame oils; are liquid at room temperature
5 Vitamins organic compounds essential for normal physiologic and metabolic functioning Most vitamins cannot be made by the body and must be obtained from diet Can be fat soluble or water soluble fat-soluble are stored by the body; A, D, E, and K water-soluble are not stored and must be ingested regularly; B and C Minerals essential nonorganic compounds found in nature that body uses Only needed in trace amounts Play a vital role in regulating many body functions Referred to by name of a metal, nonmetal, radical, or phosphate, rather than by name of compound Water essential nutrient that every part of the body needs Water-based fluids surround every cell in the body (except the outer layer in the skin) All nutrients and wastes travel through waterbased fluids Anorexia nervosa prolonged avoidance of eating; both an eating disorder and an emotional disorder Appendicitis inflammation of the vermiform appendix Bulimia overeating (bingeing) and selfinduced vomiting (purging) Cholecystitis chronic or acute inflammation of the gallbladder Cirrhosis of the liver chronic degenerative disease in which hepatic cells are destroyed and are replaced with fibrous connective tissue Colitis inflammation of large intestine mucosa Constipation infrequent of difficult passing of stools Crohn s disease progressive inflammatory disease of the colon Diarrhea frequent passing of unformed, loose, watery stools
6 Diverticulitis inflammation of the pouchlike herniations of the colon wall where muscle has become weak Diverticulosis small mucosal herniations through the muscular wall anywhere in the colon Gallstones fusion of cholesterol crystals in bile; grow in size and number and obstruct flow of bile into duodenum Gastritis inflammation of stomach s lining; can be acute or chronic Gastroenteritis inflammation of lining of stomach and intestines, characterized by nausea, vomiting, diarrhea, abdominal pain, lack of appetite, and weakness Gastroesophageal reflux disease lower cardioesophageal sphincter fails to close normally after food enters stomach Hepatitis general term for liver inflammation, which can be caused by alcohol, drugs, toxins, or viral infection Hernia protrusion of an organ through its surrounding connective tissue membranes or cavity wall Irritable bowel syndrome condition of large intestine with abnormal muscular contraction and excessive mucus in stools Obesity abnormal increase in subcutaneous fat tissue Pancreatitis inflammation of the pancreas; usually result of trauma, alcohol, abuse, or infection Peritonitis inflammation of the peritoneum; caused by bacteria Pharyngitis (sore throat) inflammation or infection of the pharynx Polyps single or multiple growths on a mucous membrane, occurring most commonly in the colon; most are benign Thrush fungi Candida albicans, affecting the oral mucosa; characterized by white plates of soft curd-like material Tonsillitis inflammation of the tonsils, especially the palatine tonsils Ulcerative colitis inflammation of the mucosa of large intestine and rectum; characterized by weight loss, intestinal ulcerations, diarrhea, and bleeding of the colon wall Ulcer lesion in a membrane
7 Summary Digestive system consists of a series of structures designed to break down food and liquids into usable body fuel To carry out digestion, body makes use of a series of specialized structures known collectively as the alimentary canal Six types of nutrients are proteins, carbohydrates, fats, vitamins, minerals, and water 37 7
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ASA Staffing Law Conference
Last year's ASA Staffing Law Conference was a great success and the expo sold out! Secure your plans to exhibit at the 2020 event, May 7–8, at the Grand Hyatt Washington in Washington, DC.
|2020 Rates
|10′ x 10′
|10′ x 20′
|10′ x 30′
|20′ x 20′
|Associate member
To learn more about exhibiting at the conference, contact Sarah Senges at 703-253-2042. For sponsorship opportunities, contact Kim Kelemen at 703-253-1169.
Staffing Law Conference Is a Can't-Miss Event for Your Company
This high-visibility annual conference is the only event dedicated to the legal and regulatory issues facing staffing companies. From federal regulatory issues and protecting temporary workers to background check parameters and health care reform, the ASA Staffing Law Conference delivers content that is critical to staffing companies. With select and limited expo space available, this is the perfect forum for suppliers to target c-suite staffing executives.
How to Exhibit
- Simply fill out the Exhibit Space Order Form.
- Check out the floor plan and select your booth preferences. Contact ASA for availability and updated floor plan.
- Submit your completed contract to ASA.
- Fill out your Complimentary Exhibitor Listing Form and send to ASA.

subset: commoncrawl


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Sting fish 5'10 20.5" 2 3/4" thick
This is a retro short board design that we first did in the '70's.
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Call the shop: 949-661-6699 or email jeremy for board or shipping info


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By Judy Packer-Tursman
Doctors trying to treat patients with nonalcoholic steatohepatitis (NASH) — a serious type of nonalcoholic fatty liver disease (NAFLD) that, if left untreated, may progress to cardiovascular disease, cirrhosis, cancer and possibly the need for a liver transplant — soon may have new options in their arsenal beyond promoting exercise and diet. The first-ever NASH drugs are expected to hit the U.S. market as early as 2020 to help address this increasingly prevalent, complex disease spawned largely by the obesity epidemic and surge of type 2 diabetes in the U.S.
Dieterich says the entry of first-ever NASH medications will "definitely" offer significant benefit to patients. "There's no question [the drugs will help] — in combination with diet and exercise," says Douglas Dieterich, M.D., director of the Institute for Liver Medicine at Mount Sinai Health System. "It will have to be the whole package."
Multiple drugs are in phase 3 clinical trials for NASH. A front-runner is Intercept Pharmaceuticals, Inc.'s drug, Ocaliva (obeticholic acid), already on the market to treat another liver condition. But the FDA isn't expected to approve Intercept's drug for NASH until the second quarter of 2020, Dieterich notes.
Dieterich says he expects NASH medications will "undoubtedly" be marketed as specialty drugs that will be "strictly controlled" by PBMs and insurance companies. He expects such drugs to become available only to the sickest patients, possibly only after a diagnostic liver biopsy is performed.
From a plan perspective, Yusuf Rashid, R.Ph., vice president of pharmacy and vendor relationship management at Community Health Plan of Washington, says NASH "has similarities to other recent new breakthrough therapies where the outcome we are trying to avoid is costly and potentially fatal but not all patients…will even progress to fibrosis. The reason why NASH is more significant is the sheer number of patients that may qualify for treatment."


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This armpit detox will help aid in the transition from any traditional deodorant including anti-antiperspirants. it is very important after using t...View full details
This armpit detox will help aid in the transition from any traditional deodorant including anti-antiperspirants. it is very important after using t...View full details
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We've moved!
This donation page is on the old Big Give website. Please go to theBigGive.org.uk to find current campaigns and opportunities to double your donation.
If you have any queries on the changes, please email us at firstname.lastname@example.com.
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Concert time
To provide a profile and fundraising concert in Manchester, the home of the National Conference of Cancer Self Help Groups


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I have been working at Ardmore since leaving college in 1995. I started my career as a receptionist, after a few years I was employed as practice manager. I enjoy my job very much but especially like the opportunity to have contact with both the clients and their pets, it provides a refreshing break from the office! Juggling a job, home, as well as a young child keeps me busy.
Homepage •
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The hell on earth that is calling customer service hotlines is eating up three days of our lives, a new study has revealed.
According to Giffgaff, we typically make calls to customer service lines about four times a year, spending around 17 minutes on hold on each occasion.
This means that the average adult, who lives to age 63, will spend close to 70 hours waiting to be put through – nearly three days.
38 per cent of callers prefer to multi-task by visiting the loo while waiting to get through; 16 per cent opt to watch a film, while 3 per cent prefer to take a shower.
About six out of 10 people admitted to feeling frustrated while left on hold, while 24 per cent feel angry.
MORE: A 'lost continent' has been found in the Indian Ocean, but it isn't Atlantis
MORE: School plans to open one hour later because pupils are struggling to get out of bed on time
The study of 2,033 UK adults also revealed the key phrases guaranteed to make a caller fume: 'Our lines are closed, please call back' topped the list, followed by 'You've come through to the wrong department' and 'Please listen to the following options'.
Ash Schofield of Giffgaff said: "What would you rather do to get your query answered – spend 17 minutes on hold to a machine or spend 90 seconds online?
"Giffgaff applauds the plucky Brits who manage to multi-task while on hold, but this research backs up what we already know – young people now want to do everything online. Surely the UK has reached a 'peak call centre' moment, so let's change a broken system."


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The U.S. Department of Justice (DOJ) selected AT&T for a potential $984 million 15-year contract. Through this award, the DOJ will transition to a next-generation communications platform supporting more than 120,000 employees across more than 2,100 locations.RapidDeploy App FirstNet Listed in App Catalog
Nellis Air Force Base Selects AT&T for 5G, FirstNet Services
APTS Says FirstNet Should Integrate Datacasting into Network, Devices
The General Services Administration's (GSA) Enterprise Infrastructure Solutions (EIS) technology procurement program includes a breadth of networking capabilities, including IP voice, data, security, cloud access and professional services. This will serve as a catalyst for the DOJ's long-term technology priorities.
The DOJ solution includes access to the AT&T mobility network and First Responder Network Authority (FirstNet). FirstNet services and AT&T's global network offer DOJ and its component organizations access to highly secure and reliable connectivity, as well as vital communications capabilities when and where they are needed, AT&T said.
"The DOJ and its component organizations do the hard work of protecting the freedoms, rights and safety of all Americans," said Stacy Schwartz, vice president, AT&T – Public Safety and FirstNet. "We are honored to provide a modern communications platform and capabilities to support the DOJ's work for the next 15 years."
EIS is a federal technology procurement that allows government agencies to cost-effectively modernize and expand mission support. The AT&T solution will provide DOJ with a balanced approach to access cloud services from multiple providers and ensuring the access is highly secure.
The new solution will help simplify cloud adoption across 43 component organizations and support the Department's Joint Cloud Optimized Trusted Internet Connection Service (JCOTS), which will accelerate the path for DOJ to access multiple cloud environments with improved security, reliability and speed.
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On 6 October 2016, the European Banking Authority (EBA) launched a Consultation Paper on the Guidelines on Information and Communication Technology (ICT) Risk Management under the Supervisory Review and Evaluation process (SREP). The draft Guidelines are addressed to competent authorities and aim at promoting common procedures and methodologies for the assessment of ICT risk.
Request for proposal


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A Joint Cyber Security Centre (JCSC) was officially launched in Adelaide on Friday 23 November 2018 as an initiative of the Australian Government's Cyber Security Strategy.
The JCSC is a partnership between business, government, academia and other key partners to enhance collaboration on cyber security.
The Adelaide Centre is one of five JCSC to be established in Australia. The Adelaide JCSC is the first co-locate AustCyber – the Australian Cyber Security Growth Network – within the Centre, demonstrating the Government's ongoing commitment to growth and innovation in cyber security.
For more information about the Joint Cyber Security Centre website.


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Looking for a portable hard drive for your laptop or PC? You might be interested to know that Amazon currently has the LaCie Porsche Design 2TB Mobile Hard Drive on sale for $94.99. That's a savings of $55 off the drive's $150 list price. With USB-C and USB 3.0 compatibility, this drive offers simple plug and play installation with virtually any PC or Mac from the past or future. When you're on the go and time is scarce, fast transfer speeds up to 5GB/s lets you drag and drop files quickly. This hard drive packs a generous 2TB of storage making it perfect for photographers, gamers, graphics artists, and video editors.
This week, Sony revealed a new miniature PlayStation, Nintendo launched its online service, a bundle of Apple products started shipping, and Amazon put its Kindles and other top devices on sale as it showed off a heap of new products. With the help of TechBargains, we've put together the best deals of the week so you can sift through the savings without hassle.
Dell Home, via its Member Purchase Program, offers its Dell XPS Tower Intel Coffee Lake Core i5 2.8GHz 6-Core Gaming Desktop PC in Black for $666.39 with free shipping. That's $134 off list, $34 under last month's mention, and the lowest price we've seen. (It's also $34 cheaper than what Dell charges via its eBay and Walmart third-party stores.) Deal ends October 30 at 8 am ET. Features include:
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It's almost the weekend and we all need to a little distraction to get us through those final hours of the workweek. Personally, I like to do a little online shopping during my work breaks. Every day, Amazon has some great deals and price drops on some of our favorite products, but it takes some digging to find them and some research to make sure they're actually a good deal. Lucky for you, I did that work for you and found some great deals on products we've actually tested, so you know you getting your money's worth.
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Metal Roof Options
We use three main metal roof options at Labron Million Construction. For example, metal roofing near me includes standing seam, concealed fastening and exposed fastening. Each roofing solution provides special benefits and a unique appearance.
Standing Seam Roofing (SSR): Of all the types of metal roofing near me, SSR is one of the most weatherproof systems on the market. Also, standing seam metal roofing has a sleek design with seams raised high above the metal panel. Our roofers install this unique roofing system with mechanical seaming by machine or by snapping the panels together. Both techniques allow for optimal leak prevention. These attractive and durable metal roof options are popular in the residential roofing market.
Concealed Fastening Metal Roof Options: This roofing system presents the same budget-friendly metal roof cost and protection as the exposed panel roofing. In addition, it is great for reducing normal wear and tear. Since we conceal the hidden fasteners beneath the panel, the panels last longer. They are not exposed to everyday weather. Typically, the fastening metal roofing near me is snapped on. This option allows for strong lines that add to the aesthetic appeal of your home.
Exposed Fastening Metal Roof Near Me: Also known as through-fastened, this system is installed with screws of fasteners. These tools penetrate the metal panels and the heads remain visible. Exposed fastening is the traditional metal roofing option. Unfortunately, due to improper installation, exposed metal roofing has earned a tainted reputation for premature rusting and leaks. However, this metal roofing near me has once again grown in popularity with watertight modern neoprene washers.
Missing damaged roof shingles? Don't wait, call Labron Million Construction today!
Metal Roof Cost Cleveland, TN
Your metal roof cost in Cleveland, TN might be initially higher than other roofing materials. But keep in mind, the investment you make in metal roofing near me will eventually save you time and money. For example, compared to shingles, metal roof options last longer, reflect heat and only require yearly maintenance. The result is a more energy efficient roof than one with traditional asphalt shingles. These cost benefits make metal roofing near me a smarter investment for your home. Call us today for a metal roof cost estimate in Cleveland!
Metal Roof Companies Near Me
The key factors that drive the success of building design are reduced maintenance costs and energy efficiency. On that note, what is great about metal roofing near me is the positive impact it makes on the durability, sustainability, and longevity of a building. All of these advantages outweigh the benefits of choosing asphalt shingles. With all of these options, only the best metal roof companies near me have the expertise and experience the help you choose the right roof for your property. Labron Million Construction is one of those companies.
Given the many metal roof companies near me and metal roof options today, it is important to understand your choices before making a decision. If you're having trouble deciding or want to learn more about metal roof systems, contact Labron Million Construction.
See our Shingle Roof Contractors Decatur, TN page for even more info on what shingle services we can provide for you.


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With the latest advances in areal surveying and airborne remote sensing we are providing clients with rapidly delivered mapping of the highest quality in Iran
Southern Mapping Company (SMC) is the largest privately owned airborne and satellite imaging company on the African continent. Based in Fourways Johannesburg, the company was formed on 1 December 2006 with the aim of providing aerial LiDAR surveys to clients worldwide that provides topographic surveys and mapping for a variety of industries and sectors. These include civil engineering and infrastructure development, mineral explorations and mine management, environmental planning and rehabilitation, and urban and agricultural planning.
Over the years SMC has grown into a leading geospatial service provider, produces a guaranteed high-quality product, delivered on time. SMC's air operations are approved by independent industry advisors, Hart Aviation and Litson & Associates. SMC's team comprised of professional Land Surveyors, Geologists, Remote Sensing Specialists and GIS personnel. Sothern Mapping company has an ISO 9001-2008 quality management system that has been certified through TUV Rheinland since 2008.
Southern Mapping Company's technologies and services are as follows:
- LiDAR & ORTHO-IMAGERY SURVEYS
- SATELLITE IMAGERY (OPTICAL; new collect and archived; including DEM's)
- SATELLITE DATA (RADAR including subsidence monitoring)
- Supervised and Unsupervised classification to aid in Exploration using Multispectral satellite data such as ASTER;
- HYPERSPECTRAL MAPPING (at resolutions of 1m to 3m, for mapping of vegetation species, soil types, surface mineralization)
- Handheld Spectrometer Field Measurements / Drill Core Scanning
Signal Delta Pars (SDP) in partnership with SMC is committed to benefit Iranian companies with latest technological advancements in airborne and satellite imaging in mining and other industries.
Website: www.southernmapping.com


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Land Rover Range Rover 5.0L V8 Supercharged
The 2016 Land Rover Range Rover. With fewer than 35,000 miles on the odometer, this 4 door sport utility vehicle prioritizes comfort, safety and convenience. Under the hood you'll find an 8 cylinder engine with more than 400 horsepower, and load leveling rear suspension maintains a comfortable ride. A wealth of standard features means that you no longer have to sacrifice. Like power windows, mirrors, and seats, voice activated navigation, a trip computer, an automatic dimming rear-view mirror, automatic dimming door mirrors, a power liftgate, skid plates, and seat memory. Rear passengers enjoy the seat heating functionality, keeping them warm during the winter months. With high intensity discharge headlights illuminating your path, you'll always appreciate maximum visibility. For drivers who enjoy the natural environment, a power moon roof allows an infusion of fresh air. Passengers are protected by various safety and security features, including: dual front impact airbags with occupant sensing airbag, front side impact airbags, traction control, brake assist, anti-whiplash front head restraints, a panic alarm, an emergency communication system, and 4 wheel disc brakes with ABS. Safety and maximum capability are assured via self leveling rear suspension, which maintains optimal driving geometry. It also arrives with a Carfax history report, indicating just one previous owner. We pride ourselves in consistently exceeding our customer's expectations. Stop by our dealership or give us a call for more information.


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Cell Communication: Hormones and Neurotransmitters
Hey it's professor Dave, let's learn about
how cells communicate with one another. We've learned about a lot
of the complex biochemistry that occurs inside every single one of your cells,
but it actually gets even more complicated than that, because your cells
need to communicate with one another in order to respond to environmental
stimuli like potential danger and to elicit certain behavior during various
stages in your lifetime so that your body makes the correct changes as you
grow. How does this communication take place? Well we learned about receptors
that sit in the cell membrane and wait for a particular substrate to bind. Many
of these receptor substrates are signaling molecules like hormones and
neurotransmitters, which upon binding to the receptor set off the process of
signal transduction, which can have a variety of results. Some of this
signaling is local, occurring between adjacent cells, but long-distance
signaling can also occur, where a message travels all the way across your body to
deliver a signal to a particular type of cell. In examining these signaling
pathways we want to talk about three types of signaling. Those are autocrine,
paracrine, and endocrine. The prefix auto means "self", so autocrine signaling refers
to when the cells secrete signaling molecules which then bind to receptors
on that same cell. This will trigger some kind of response
from the cell. The prefix "para" means beside or nearby, so paracrine signaling
is a type of local signaling where a compound like a growth factor is
secreted by a cell which then interacts with nearby cells. Growth factors are
signals that tell a cell to begin dividing which is what allows us to become so
much taller during intense periods of growth in childhood. Another example of
local signaling is called synaptic signaling. This is how messages travel
through your nervous system. A nerve cell can be triggered by an electrical signal to release certain molecules called
neurotransmitters into the synaptic space, which then interact with the next
nerve cell, eliciting another electrical signal which releases neurotransmitters
into the next synaptic space, and so forth. A nerve cell can also be attached
to a muscle cell which makes it able to trigger muscular contraction. This kind
of signaling is used when your hand needs to tell your brain that something it
is touching is hot, which will then send another signal back down to your hand to
tell it to stop touching it. An incredible amount of chemistry has to
happen for all those signals to be transmitted, but lucky for us chemistry happens imperceptibly quickly.
And lastly, the long-distance signaling that happens in our bodies occurs via
endocrine signaling. This is when a particular type of compound called a
hormone is released by a gland and is then carried through the bloodstream to
its destination. This system has a range of functions
like maintaining blood pressure, the regulation of development, and more. So
what are the names of some of these hormones and neurotransmitters and what
exactly are the messages they carry? Many of the signaling molecules fall into
three structural categories: polypeptides like oxytocin, steroids like cortisol, and
amines like epinephrine. We've already learned about the properties of these
types of molecules so let's talk about how they interact with the body. First
let's discuss their variance in solubility. Polypeptides and amines are
water-soluble whereas steroids are not. But nonpolar molecules like steroids are
lipid soluble, so this discrepancy will affect the way these molecules are
transmitted. Water-soluble hormones can travel through the aqueous bloodstream
freely but they can't pass through the nonpolar plasma membrane of a cell so
these will typically be recognized by receptors on the surface of the cell,
which upon binding will initiate signal transduction. For example, when an
organism finds itself in a particularly stressful situation, like evading a
predator, the adrenal glands secrete a hormone called epinephrine. This is more
commonly known as adrenaline. When this molecule reaches liver cells it binds to
a membrane receptor. This sets off a cascade of events which generates cAMP, which in turn activates an enzyme called protein kinase A. This enzyme will
inhibit glycogen synthesis and promote glycogen breakdown. This means that the cell will stop
storing glucose in the form of glycogen and will instead start breaking up
glycogen to make more glucose molecules, which will enter the bloodstream and
become available for cellular respiration. Essentially it kicks energy
production into overdrive so that the organism can get away from the predator.
By contrast, lipid-soluble hormones will have to bind to transport proteins in
order to be soluble in the bloodstream but once they reach a cell they are
typically able to pass right through the cell membrane, being nonpolar, so the
receptors that interact with these types of hormones are usually already inside
the cell. For example, in many vertebrates like birds and frogs, estradiol is a
hormone that regulates female reproductive function. This can enter a
liver cell and bind to a receptor in the cytoplasm. This complex will then undergo
a conformational change due to the binding that allows it to enter the
nucleus, bind to a specific DNA sequence and transcribe the gene for vitellogenin.
Once produced, this protein is then transported to the reproductive system
to produce egg yolk. Some lipid-soluble hormones pass through both the cell
membrane and nuclear membrane to bind to a nuclear receptor. Again, nuclear
receptors are typically transcription factors which once activated, will
initiate the expression of a particular gene. Some hormones elicit multiple
responses simultaneously. Let's look at epinephrine again. Not only
will this promote glycogen breakdown but it also increases blood flow to skeletal
muscles and decreases blood flow to the digestive tract. How can it do all these things at once?
It's partially because different cells might contain different enzymes than
others and therefore elicit a different cellular response to the same hormone.
But also some hormones are able to activate several completely different
receptors each with their own unique response to binding. Here we can see two
different receptors called alpha and beta receptors existing on three
different cell types, as well as each unique result, whether increase of blood
glucose, blood vessel dilation, or blood vessel constriction. As we said, all
hormones are secreted from glands. Here are just some of the glands in your body,
including the hypothalamus, thyroid, pineal, and pituitary glands, as well as
the hormones they mediate. Many of these may sound familiar and they have a wide
variety of functionality, including the regulation of biological rhythms like
your sleep cycle as well as growth, metabolic functions, and social behavior.
There are far too many to go through them individually but it is more
important that we understand the general mechanisms by which they operate so that
we can apply this understanding to any individual example. And most importantly,
we must understand how the endocrine system and the nervous system work
together to play a critical role in organizing all the cellular activity of
an organism to contribute towards a common goal: the survival of the organism. Thanks for watching, guys. Subscribe to my channel for more tutorials, and as always, feel free to email me:


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Sold Out Rs. 1,150
Rhinodillos Tire Liners. RhinoDillos tire liners prevent thorns and other road debris from puncturing an inner tube and deflating the tire.
In the past have owned 4 Schwalbe Marathon Plus Tire , the tires lasted well over 10K KM in Bangalore roads mostly tarmac with few (ok many!) potholes. Over the last 4 years I had 3 flats. I decided to go for a tire liner for a change and got the RhinoDillo with normal Continental tires. Was able to fix it easily. My reason for tire liner was for endurance ride and dependability for my long rides so far it has been satisfactory on both the points ( review based on 400KM ride). Ride is smooth and yes dont trim it just overlay the extended portion. I would recommend them and yes hats off to BOTS as usual for the fast delivery.


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Order your digital copy of our Meal Plan and get immediate access. Your digital copy has a maximum of 3 downloads, and can be downloaded onto any device.
This is a digital copy only. We ask that you please DO NOT SHARE with others as this is a family-owned and operated business. Please note that the digital file will be emailed to you immediately upon purchase. THE LINK IS VALID FOR A TOTAL OF 3 DOWNLOAD ATTEMPTS. PLEASE DOWNLOAD PERMANENTLY TO A DEVICE.
We love and respect our community and ask that you please be respectful to our business by not sharing your digital copies with others or outsourcing unauthorized copies to be printed. We allow 1 copy to be printed at home but do NOT authorize printing at third party printers. ❤
The Clean Simple Eats Meal Plan was created for the foodie in all of us! Each book includes:
90+ simple, delicious, family-friendly, macro-friendly recipes (completely different recipes compared to recipes in our Spring, Summer, or Winter books)
7 weeks of grocery shopping lists
7 weekly menu planners
Nutrition information (macros and calories) for each recipe
Food prep guide
Full week of beginner workouts
Full week of advanced workouts
Information about macros if you're brand new to macro counting!
You do not have to eat bland and boring meals to reach your goals! We use recipes that actually taste good that will help you to create a healthy lifestyle for you and your family; it's not a quick fix. You can use the menu planners and grocery lists as we suggest, or you can simply use this book as a cookbook and work through it at your own pace picking and choosing the recipes that look the best to you. Every dinner makes 4 servings as well as some of the breakfasts. Most snacks and other breakfasts are made to serve one.
To join the CSEchallenge, get more details here.
For a list of ingredient substitutions if you have allergies or dietary restrictions, please view our swaps list HERE.
Please Join our challenge group HERE & follow me on Instagram @CleanSimpleEats for added information, live videos, prizes and accountability throughout our challenges.
There will be no upgrades from the digital to the hard copy.
Thank you for your interest in our books. We truly hope that you love them as much as we do! Thank you for your support!
Customer Reviews
- Reviews
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- family
- husband
- recipes
- book
- cookbook
- meals
- food
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I have never had an easier time making dinners and not feeling totally disgusting after consuming the food! I love how there are enough portions for two dinners and leftovers for lunch the next, it's saved me so much time with making lunches and all the stress that comes with meal prepping. I've struggled with IBS symptoms for a couple of years and it's exacerbated when I eat carb heavy foods. I love your meals because they're balanced in macros and I haven't had a flare up in a year!!!
Perfect for cool Nights
I love these recipes! We have a few favorites that the entire family loves. This book has been great for our family. I love the meal prep and planning and all the help getting the meals ready for the week. It's so amazing for our busy family.
My favorite
I have all 4 seasons, and this one is my favorite! My husband has also likes the recipes in this book. Thankful for healthy recipes that we both enjoy!
I thought the winter meal plan was my favorite until I tried the fall one. Love it so much I often pull from this book even when it's not fall! I make the taco soup basically weekly and the butternut squash soup is amazing too!
Delicious Food!!
I love this cookbook! I love how it has options for snacks and desserts! CSE meal plans are game changers healthy food but you don't feel restricted because the food is so good!


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Some of the following material is not in the public domain.
It is illegal to copy and distribute our copyright-protected material without permission. Printing copyright texts or translations without the name of the author or translator is also illegal.
You must use the copyright symbol © when you reprint copyright-protected material.
For more information, contact us at:
Before writing, please read the instructions below the translations (under Authorship). Always include the names of the translators in your email if you wish to reprint something!
Who never choked on tear-stained bread, who never spent his nights in sorrow, but weeping on his sleepless bed, knows naught of Gods that shape tomorrow. Who never ate with tears his bread, who never wailed away till morrow deprived of sleep upon his bed: he knoweth not ye Gods of sorrow: You lead the human into life you let the poor soul fail, God-fashion, then leave him to his pain and strife: for punished must be each transgression! You force a man into his life, you let the poor man sin in passion, then let him suffer hurt and strife, aware that pain rewards aggression! You stain a man with guilt's impression, and then abandon him to pain: For life avenges all transgression!
About the headline (FAQ)Note: this is a free singable translation of the Schubert song with its repeats (but not with the same English words repeated). Text mit Wiederholungen wie in Franz Schuberts dritter Version dieses Liedes. See http://myweb.dal.ca/waue/Trans/God.html for some interesting notes.
- Singable translation from German (Deutsch) to English copyright © 2010 by Walter A. Aue, (re)printed on this website with kind permission. To reprint and distribute this author's work for concert programs, CD booklets, etc., you must ask the copyright-holder(s) directly for permission. If you receive no response, you must consider it a refusal.
Walter A. Aue.  Contact: waue (AT) dal (DOT) caIf you wish to commission a new translation, please contact:
- a text in German (Deutsch) by Johann Wolfgang von Goethe (1749 - 1832), "Harfenspieler", written <<1783, appears in Wilhelm Meisters Lehrjahre, first published 1795
Text added to the website: 2010-03-26 00:00:00
Last modified: 2014-06-16 10:03:37
Line count: 19
Word count: 124


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Hello! My name is Abbey Allen.
Animals are my life! Growing up in East Hampton I always had pets as a child. After I graduated school in 2000 pet sitting just came naturally. While I pursued a career in photography, I would spend my nights sleeping in peoples homes caring for their pets.
My husband and I were married in 2007 and in 2009 we welcomed our son Austin into the world. When Austin was born my life switched gears. I became a stay at home mom and pet care became my full-time gig. Raising my son in a pack of dogs has taught him limits along with compassion, love and responsibility.
Each dog has their own unique character and quirks. Discovering and working with those quirks is my passion! My family's days start and end with puppy love and I wouldn't have it any other way!
Private walks around your neighborhood or on the beach.
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- Why Burundi?
- Legal System
- ICT Governance
- Invest
- Mkono & Co
This guide is prepared by:
Mkono & Co
Both national or foreign individuals or legal entities, either in private or public law, "may be Associated if it meets the capacity requirements prescribed by law and regulations and is not subject to prohibition or incompatibility enacted in special laws" (article 4 of the Burundian Companies Code dated 30 May 2011).The same Code recognizes various types of companies. The various types of companies are divided into two main groups in the Code, Private and Public Companies.
Two forms of companies that are commonly incorporated are the SPRL and the SA. The SPRL (Société de Personnes à Responsabilité Limitée), is a private limited liability company which requires at least two (2) shareholders with a maximum of fifty (50) shareholders and has no board of directors but one or two managers. The liability of the company is limited to the company's assets and to the shares in that company. The SPRL is managed by a general assembly and general shareholders meetings.
The S.A., (Société Anonyme), is a company limited by shares which requires at least three (3) shareholders without limitation of shareholders and has a board of directors with at least two (2) directors which must all have at least one (1) share each. The board of directors appoints a managing director. The liability of the company is limited to the company's assets and to the shares in that company.
The various other most common forms of companies are the following:
- Private Companies:
- The SURL (Société Unipersonnelle à Responsabilité Limitée) is a single shareholding company; and
- Cooperative Company.
- Public Companies:
- Public Company ; and
- Semi-public Company.
Once the type of company has been decided on, the process to incorporate a company may then be followed. As from 6 March 2012, Burundi Investment Promotion Agency (API) introduced the "one-stop-shop" which is a consolidation of various business registration steps and entities into one which has made registering a business in Burundi faster and cheaper. Incorporating a company using the "one-stop-shop" now usually takes 1 – 3 working days.
There are no set restrictions for incorporation just requirements in the form of what documentation is required for example the identity documents of the shareholders. Since the API was introduced, the process of incorporation is simple with companies, should they opt for the assistance of a lawyer, sending powers of attorneys, copies of IDs and the forms filled out for the process to be done.