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|Arakawa, Akiko; Vollmer, Sigrid; Besgen, Petra; Galinski, Adrian; Summer, Burkhard; Kawakami, Yoshio; Wollenberg, Andreas; Dornmair, Klaus; Spannagl, Michael; Ruzicka, Thomas; Thomas, Peter; Prinz, Jörg C. (2018): Unopposed IL-36 Activity Promotes Clonal CD4(+) T-Cell Responses with IL-17A Production in Generalized Pustular Psoriasis. In: Journal of Investigative Dermatology, Vol. 138, No. 6: pp. 1338-1347
Generalized pustular psoriasis (GPP) is the most severe psoriasis variant. Mutations in the IL-36 antagonist IL36RN, in CARD14 or AP1S3 provide genetic evidence for autoinflammatory etiology but cannot explain its pathogenesis completely. Here we demonstrate that unopposed IL-36 signaling promotes antigen-driven and likely pathogenic T-helper type 17 (Th17) responses in GPP. We observed that CD4(+) T cells in blood and skin lesions of GPP patients were characterized by intense hyperproliferation, production of the GPP key mediator, IL-17A, and highly restricted TCR repertoires with identical T-cell clones in blood and skin lesions, indicating antigen-driven T-cell expansions. The clonally expanded CD4(+) T cells were major producers of IL-17A. IL-36 signaling substantially enhanced TCR-mediated proliferation of CD4(+) T cells. Moreover, GPP patients showed preferences for HLA-DRB1*14, HLA-DQB1*05, and HLA-DQB1*03. We conclude that in GPP unopposed IL-36 signaling and certain HLA-class II alleles may cooperate in promoting antigen-driven Th17 responses, which in the obvious absence of exogenous triggers may reflect autoimmune reactions. This study reveals a pathogenic pathway where innate immune dysregulation promotes T-cell-mediated inflammation in GPP.
|Item Type:
|Journal article
|600 Technology > 610 Medicine and health
|ID Code:
|Deposited On:
|19. Jul 2019 12:15
|Last Modified:
|19. Jul 2019 12:15
- Google Scholar


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The multi-use hiking trails on Mitchell Hill got a major improvement last Wednesday, July 1, with the installation of 20 trail marker signs. The 312 acre trail system, acquired by the National Park Service in 2010, services hikers, bikers, and horse riders and now has a total of 24 trail signs.
"We have really enthusiastic users of this place," said San Juan Island National Historical Park Superintendent Lee Taylor. "It's really a unique thing in the Parks Service to get people to work together for multi-use trails."
The Mitchell Hill trails were known for being difficult to navigate, with locals and visitors alike getting lost. The new signs designate two different loops, one longer and steeper than the other shorter and easier loop, and every sign points which way back to the Horse Trail Road parking lot.
Taylor says the signs are a collaborative effort between trail users and organizations alike. The National Park Service worked with National Parks Conservation Association who funded the signs, which were installed by SJI Youth Conservation Corps and San Juan Island Trails Committee. NPS also works with San Juan Island Conservation Corps to clear hiking trails on Mitchell Hill.
According to Taylor, Mitchell Hill is generally uncrowded, which she believes will change with the installation of the trail signs and trailhead kiosk to be built later this summer.
"It's an improvement because we had people who hesitated since it was confusing to hike out here," Taylor said. "We think that they'll be encouraged to come out."
Mitchell Hill connects trails to English Camp and Roche Harbor Highlands which is private property that allows hiking, biking and horse riding.
Mitchell Hill will be featured in the SJI Trails Committee Know Your Island Walk Sept. 26. Watch the paper for details.

subset: commoncrawl


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Welcome! We hope you find our page helpful. If you're interested on any of our courses or scholarships, feel free to ask us.
Welcome! We hope you find our page helpful. If you're interested on any of our courses or scholarships, feel free to ask us.
(Updated as of Jul 25, 2018)
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Riverside College, Inc. (RCI) is a private, Catholic higher educational institution in Bacolod City. It was founded by Dr. Pablo Obrego Torre, Sr., who also established the Riverside General Hospital (became Riverside Medical Center in 1972 and is now Dr. Pablo O. Torre, Sr. Memorial Hospital). The college started with the School of Midwifery and the School of Nursing as a response to the need for competent staff in the hospital.
Specializing in paramedical and healthcare courses, the college has degree programs in Medical Technology, Physical Therapy, Radiologic Technology, Pharmacy, and Nursing. Also available are courses in Business Administration, Entrepreneurship, and Psychology. RCI also has a Senior High School (SHS) department offering strands under the Academic Track and the Technical-Vocational-Livelihood (TVL) Track.
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Research has reached great heights in the subject of health and wellness all over the world. It is very important for us to keep ourselves informed of the current health events to educate ourselves and our families in regards to the different kinds of diseases roaming outside of our houses on regular basis. Awareness in the field of medical discoveries and the effects of these discoveries in the present scenario are very important and every individual should take time to learn and educate themselves accordingly.
Unfortunately, this knowledge and education is not available to those who really need it the most, the illiterate and the people that fall under the low strata of society especially in poor countries. However, the amount of people who are fortunate enough to have access to the current health events is very vast and there are many government and private organizations all over the world who are trying to take the knowledge of the latest information on all aspects of health and wellness to the people.
The human body is a very complex machine and one of the higher challenges the medical fraternity has had to encounter perhaps is the point that not everybody react the same to the same treatment and not everybody is affected by a disease or a disorder in the same manner. There are many similarities which of course help the professionals in these fields understand the symptoms and give the right diagnosis, however, the variations with some of the not so common problems can be very difficult to detect and understand. Current health events help us understand the differences that these symptoms and reactions may have in our system and they help us understand how our physical bodies function and react to diseases.
Many drugs have been researched for specific symptoms and the research has reached the stage where you are hundred percent sure of the results. However, current health events also help us understand the side effects of some of these drugs which also vary from person to person. For example, a drug which may be good for you for your blood pressure, may not be good for someone else suffering from depression and anxiety.
However, since there is so much to try to learn and understand, then it is probably better to take one step at a time and first get proper information and education on current health events related to a subject you are interested in. Preference will of course be given to a present ailment or to a health experience you have had you wish to understand better.


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Are you going to the office with a suit? Do you use business cards? Do you still print documents to read later? Sorry, then you are not ready for digital transformation.
The digitalization process of any company goes beyond being at the forefront in technology. It is also a change of attitude, of profound renewal in order to quickly adapt to the digital environment and its needs.
But companies are not only formed by formal relationships, there are also a series of informal indicators, very easy to identify, that help us predict whether or not a company is ready to carry out their digital transformation.
In this infographic we collect 7 of these informal indicators that detect in a very graphic and intuitive way if a company is on the right path of business digitalization… or not.


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Indian fast bowler Mohammed Shami's tussle with wife Hasin Jahan has grabbed a lot of eyeballs since March and the intensity of the issue has always increased with each and every development of events. Jahan earlier alleged Shami of domestic violence, match-fixing, extra-marital affairs and delivering death threats. The issue went to such an extent that Shami's cricketing career also came under the scrutiny.
The Board of Control for Cricket in India (BCCI) even withheld Shami's contract and investigations were done on the match-fixing accusation. However, the scenario gradually kept turning in favor of Shami and he was proven innocent. Subsequently, he was awarded a Grade B contract to play for the national team. Thereafter, Jahan contacted many eminent personalities to try and prove his husband guilty.
ALSO READ: Hasin Jahan Alleges Shami Of Age Fudging With Proof
Recently, Shami has finally got some signs of relief as his wife lost the maintenance lawsuit on Friday. Earlier, Jahan demanded INR 7 lakh per month from the Indian pacer as a part of family maintenance, but her requests have been rejected by the Alipore Court as per reports in Zee News. Previously Shami refused to pay her for the reason that she had started her acting and modeling career again.
Hasin's attorney has defended her by saying that she is trying to commence her career again, but it hasn't got off the blocks yet. However, Neha Sharma, the judge, has approved the claim for their daughter. Shami has been asked to pay INR 80,000 per month for the daughter. Shami's advocate mentioned that the fast-bowler is ready to pay for her daughter ever since the beginning.
Back in April, Jahan demanded a monthly compensation of INR 10 lakhs for the time the case is on. She asked for INR 7 lakh for her maintenance and INR 3 lakhs for her daughter. Shami is currently in England where he is representing the Indian national team in the five-match Test series against Joe Root and his men.


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On February 22-23, the Flashes competed at the IHSAA State Championship at IUPUI. The 200 Medley Relay team of Nathan Boomershine, Alex Schreiner, Joe Brabender, and Tuan Tran finished 25th with a 1:39.71. Brabender finished 26th in his 200 Individual Medley with a 1:58.0. Boomershine qualified for Finals on 2/23 in the 50 Freestyle and 100 Backstroke. in the 50, Boomershine finished 10th with a 21.18. Boomershine lowered his school record in the 100 Backstroke to 51.26 on his way to a 14th place finish.
Boys Varsity Swimming · Boys Varsity Swimming finishes 36th place at IHSAA State Finals
|Franklin Central High School


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Debbie Dragon A formal business plan is an important document for any business. Any other items that pertain to your business as an expense should be defined before you set out to create your business financial plan. Be simple, clear and as direct to the point as possible. If you are starting a new business and do not have these historical financial statements, you start by projecting a cash-flow statement broken down into 12 months.
The answering machine is to be attended to every morning and the calls returned immediately. You will have a complete understanding of the POS terminal as well as the credit card terminal and their functions. As you can see, writing a business plan requires a commitment of time and resources to ensure all relevant information is present.
Follow up with the clients you service.
Department of Labor, it shows cosmetology as a steadily growing occupation in the U. Here's some advice on how to include things like a sales forecast, expense budget, and cash-flow statement. Attendance at an advanced academy of education committing to updates on a national level annually.
Placing the clients' needs first. Handle all phone calls politely and professionally using your name when answering the call. You're going to need to understand how much it's going to cost you to actually make the sales you have forecast. It is your responsibility to educate the clientele you serve.
Set forth new projections if you own an existing business. Offer a beverage, reading material, and take their coat. You don't want to be surprised that you only collect 80 percent of your invoices in the first 30 days when you are counting on percent to pay your expenses, she says. Artistic Director As the artistic director you hold a strong leadership position within the company as well as within the community.
It is used by many salons. Education is key to profitability.
It is your part as a team to communicate the company's vision and mission to the clients you service, taking a holistic approach to nail care. Participate with the team. Because you want to calculate gross margin. Estimate your start-up costs if you are starting a new business.Gaming Futures, LLC computer programming business plan executive summary.
Gaming Futures is a start-up computer programming studio providing application development/support for the major computer/video game platforms. This is a great article on the details of creating a Return Order in AX How though do others handle Miscellaneous type charges, i.e., Restocking Charges, Pallet Charges etc.
Currently we create a Sales Order with a negative line item(s) for the products coming back or being scrapped and then have items set up for the additional charges. Business Plan Pro is the fastest, easiest business plan software for small business, startups, and corporate business planning.
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If you still feel like you are a candidate for starting-up and running your own record label, then It's now time to start learning how to write a music marketing plan based on The Four Fronts of Music Marketing' that the book 'Music Is Your Business; A Musician's FourFront Strategy for Success', 3rd Edition is all about.
Before I start getting into all the details involved with.Download


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Newton continues to improve the speed and performance of it's leading applicant tracking system and simplifies integrations to employers' careers sites with December enhancements.
In the midst of working on one of Newton's biggest feature upgrades to date, Interview Scheduling, Newton's product team has released two significant upgrades available now to employers using Newton's hiring software.
Database Performance Upgrades Makes Newton the fastest ATS available
Newton's product team has just upgraded all databases to SSD-based instances in Amazon's Cloud environment. Who cares? Well, SSD has access speeds of 35 to 100 micro-seconds, which is nearly 100 times faster than previous database instances. This faster access speed means Newton will be run more quickly, which is very significant, especially for features that access and process large amounts of data like recruiting analytic and reports.
Simple, Smart, Safe Careers Page Integration Improvements with Single-Line iFrame Codes
With Newton, there are 3 options that employers can choose from to integrate job listings from their Newton account onto their websites. One of the most common options is to use an iFrame. An iFrame (inline Frame) is an HTML document embedded inside another HTML document (an employer's careers page) on a website. With Newton, the iFrame HTML element is used to insert job content from an employer's Newton account onto their careers page.
This week, Newton upgraded the iFrame careers page option making it a simple (10-15 minute) project for any web or IT administrator. Newton's new single-line iframe functionality allows web masters to paste a single line of code into their career's page code. Extended features empower web masters to control scrolling and advanced CSS customization providing employers with a fully-branded, easy-to-administer integrated applicant experience.


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Full Throttle Auto Sales
Different Motor Installation Two Widespread Problems Of In-dash DVD GPS Navigation System Efficiency Rating of Michelin Tips on how to select a generator set? Things have gotten expensive day by day and so are the car accent installments and their repair. Providers are becoming costlier to customize our car, so it's time we do it ourselves as it's an easy job.
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When you consider it fastidiously, we spend a huge portion of our lives working. In one week there is 168 hours of which the common individual spends at the least forty hours working. Then it's a must to … Read More


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Email:[email protected]
China Emerges Tanzania's Major Investor - Ventures Africa. Jan 29, 2014 China Emerges Tanzania's Major Investor China's total direct investment in Tanzania soared from $700 million in 2011 to $2.1 billion last year, turning the world's second biggest economy into the biggest foreign investor in the east African country, it has emerged.More
2019-10-21 As a result, the major coal mining companies have freed up coal deposits deemed uneconomical to mine, and have made noncore assets availe to BEE coal mining companies, while also entering into numerous joint venture agreements. Africa Mining IQ is a leading coal mining intelligence source. Providing essential information on South African andMore
2019-10-27 Production (and consumption) of agricultural plant commodities has a diverse geographical distribution. Along with climate and corresponding types of vegetation, the economy of a nation also influences the level of agricultural production. Production of some products is highly concentrated in a few countries while other are widely produced.More
For over 35 years, Coaltrans has been the biggest international coal-trading events provider in the world. Annually our events bring together over 3,600 consumers, producers, traders, shipping companies, and the major stakeholders in transporting coal around the world.More
2016-8-15 Top Wood Charcoal Exporting And Importing Countries Paraguay and Germany are the top charcoal exporting and importing countries, respectively. Charcoal is an important fuel source globally, and its production provides employment to masses of people.More
2019-10-12 The following lists some of the larger power stations in Indonesia. Data are not included for a large number of small isolated plants (mostly diesel) in the Outer Islands. In total, the PLN operated over 5,000 plants across Indonesia in 2010 of which over 4,500 were small diesel plants outside of Java.More
2017-9-7 In recent months, the government of Tanzania has tightened its control over its natural resources and the mining sector in particular through a serious government crackdown on tax evasionMore
2014-8-30 Currently, there are 500 companies that are participating in Africa hydrocarbon exploration. The continent's history of oil stretches back several decades and in some places, it is a century old. In this article, we'll be looking at highest oil producing countries in Africa, we hope you'll find it interesting.More
Huge directory of Agriculture,Chemicals, Plastics, and Raw Materials,Construction Real Estate,Home Appliances,Minerals Metallurgy,Suppliers, DistributorsMore
2013-11-20 More than 80% of the world's total proved coal reserves are located in just ten countries. The US tops the list with more than a quarter of the proven coal reserves, while China, which ranks third, is the biggest producer and consumer of coal. Mining-technology profiles the ten countries withMore
2014-10-13 TANZANIA is set to save huge amounts of foreign exchange when the country starts commercial production and exports of iron and steel in 2018. According to the National Development Corporation (NDCMore
2011-5-2 Tanzania hopes to grow its mining industry by at least 7.7 per cent annually for the next five years. The growth of the industry will be mainly buoyed by increased investment in the production of coal, uranium and nickel — three sub sectors the government sees as potential big income earners.More
2015-5-30 Tanzania is Africa's fourth-largest gold producer after South Africa, Ghana and Mali. Tanzania also has niobium, coal, platinum, graphite, s, tanzanites, silver, limestone, soda ash, nickel and rare earths. East African Community memberMore
2012-12-8 国际商务 查尔斯W.L.希尔 第七版 原版官方PPTChap008_经济学_高等教育_教育专区 788人阅读174次下载 国际商务 查尔斯W.L.希尔 第七版 原版官方PPTChap008_经济学_高等教育_教育专区。More
2015-5-30 Tanzania is Africa's fourth-largest gold producer after South Africa, Ghana and Mali. Tanzania also has niobium, coal, platinum, graphite, s, tanzanites, silver, limestone, soda ash, nickel and rare earths. East African Community memberMore
The Liganga iron ore mine holds the biggest iron resources in Tanzania with proven reserves of 126m t Tanzania China International Mineral Resources Ltd TCIMRL will invest USD 18bn at Liganga for the establishment of iron ore mine and Iron and steel Complex to produce 10m t per year of iron and steel products vanadium pentoxide and . Live ChatMore
2015-6-19 The World's 10 Biggest Oil and Gas Companies. Note: to see the bigger version of this infographic, click here. Today's infographic not only ranks oil producers based on factors such as barrel production per day, but it also compares data from a decade ago with today's information forMore
2019-10-19 These are the top 25 biggest companies in Africa. The list shows the biggest public African companies based on their market value. This list was created by Africaranking. South Africa still dominates the list. But some countries like Nigeria and Morocco are quickly catching up.More
List of companies, huge directory, suppliers, distributors, importers, exporters, dealers, manufacturers. Business information about company profile, email, telMore
2019-10-23 This is a list of countries by salt production. The six leading salt producers in the world, Australia, Canada, China, Germany, India and the United States, account for more than half of the worldwide production. The first table includes data by the British Geological Survey (BGS) for countries with availe statistics.More
2014-8-25 The African continent is well-known for being a great resource for minerals. In fact, it prides itself on being the home to most of the precious minerals in the world. Many economies in the continent are sustained by the minerals. The following are the 10 African minerals of highest economic valueMore
2019-9-20 GREENHOUSE GASES: Spoiling The Climate The 35 biggest coal producers have been responsible for one-third of the global emissions since 1988. This was the year the Intergovernmental Panel on Climate Change was founded, and the Toronto climate conference requested governments to set targets for reducing their emissions. Allowed HTML tagsMore
2013-9-29 Indonesia is home to the world's biggest gold mine while South Africa, which houses the majority of the deepest mines in the world, also hosts two of the top ten largest gold mines. Mining-technology profiles the top ten biggest gold mines in theMore
2012-2-29 The resource space is currently recovering from a bear market, and the overall consensus is that a lot of companies that are creating shareholder value are still pd well below what they are worth.More


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Why choose UNIXO
The UNIXO concept comes from a detailed analysis of the market needs: a deep-articulated study that is valorized by the undisputed quality of the MADE IN ITALY products. The 30-year old experience of its founders and the partnership with UNIVERCIOK, Italian company, leader in the HO.RE.CA. branch, that since 1983 produces semifinished dessert products, make UNIXO a unique and inimitable project. Choosing to open a UNIXO-branded coffee shop means entrusting a "full service".
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An army soldier committed suicide in 217 Pamir Corps
Kabul-Afghanistan (PMG):
Reporter: Mehrullah Mehrdad
An army soldier in the northeast of the country committed suicide last night. Some security sources that do not want to be named, said that the soldier has hanged himself. According to the security source this soldier was charged murder and he has been jailed for several months. The source continues to emphasize that the soldier was in bad spirits.
In addition, it is said that the soldier had suffered from mental illness, so far, 217 Pamir Corps officials have not stated their view on this issue. The report was released while a military soldier had suicided recently because of his father's death in Kunduz.
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Classic Mountain Views As Trek Wall At Jinshanling
Jinshanling Great Wall starts from Longyukou in the west and ends at the Wangjinglou Tower in the east and stretches about 10.5 kilometers. It is located on the Yanshan Mountains, 140 kilometers away from downtown Beijing, where Miyun County borders with Luanpin County in Hebei Province.The Jinshanling Great Wall is acomplicated and well preserved fortification systems and possesses the largest number of watchtowers.
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Last Update : Feb 28, 2019
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Kia Sportage LX
Climb inside the 2020 Kia Sportage. Under the hood you'll find a 4 cylinder engine with more than 170 horsepower, and for added security, dynamic Stability Control supplements the drivetrain. Top features include air conditioning, a trip computer, front bucket seats, front fog lights, power door mirrors, remote keyless entry, cruise control, and power windows. Audio features include an AM/FM radio, steering wheel mounted audio controls, and 6 speakers, enhancing the audio experience throughout the interior. Kia ensures the safety and security of its passengers with equipment such as: dual front impact airbags, front side impact airbags, traction control, brake assist, a panic alarm, and 4 wheel disc brakes with ABS. Sophisticated all wheel drive technology maintains a firm grip on the road. Our sales staff will help you find the vehicle that you've been searching for. We'd be happy to answer any questions that you may have. Please don't hesitate to give us a call.


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The Downtown Excelsior Partnership will host Mug Shots, a fall event favorite, on Saturday, September 7, in downtown Excelsior Springs. You will be able to sample beer at multiple participating locations. Some of the locations will be serving more than 1 sample! You're sure to get your monies worth! You will also have the choice of participating ina poker run game. Make sure to act fast and purchase your tickets now, we sell out at 300! We have 15 different locations and over 25 craft brews! An added bonus is that when you purchase tickets, you will have free access to use the trolley as you navigate from stop to stop in downtown Excelsior Springs
Atlas Saloon Brewery
Blue Bird Couture
Bohemian Sage Gallery
Broadway Bar & Grill
Dubious Claims Brewing Co.
Elms Hotel & Spa
Herradura Mexican Restaurant
Main Spring Art Gallery & Studios
Molly Roberts Studio
New Age Skincare Spa
Shelby's Stiletto Factory
Style By Ry
The Farmhouse
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Willow Spring Mercantile
Online Ticket Sales Now Closed!
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Thank you for positioning about this subject.
My plan is to use
_pycodecs.py in Grumpy, propose it to be used on RustPython and look for others and their interest (Micropython and Transcrypt to start).
Micropython for example support only utf-8, is not extensible and have
codecs.py as a dummy. Having
codecs.py importable in this environment would fix some issues on their side.
In fact, I already started hacking a
Side question:
Is there a performance reason for this to be a
tuple or I can replace with a bare old
object to simplify some code? Assuming backwards compatibility and tests passing, of course.


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Who We Are
We are a Church of England parish church, and are part of the CRoFTT Benefice, a group of five churches in the area including St. Leonard's Tortworth, St. James' Tytherington, St. George's Falfield, and St. Oswald's Rockhampton.
Please direct all enquiries regarding weddings, funerals and baptisms to the Benefice Office which can be contacted on 01454 260096 or email@example.com.
Life Prayer
God of hope and transformation,
who in our Lord Jesus Christ offers the gift of life in all its fullness,
send your Holy Spirit and grant us
joy in our following and vision in our leadership.
May we be rich in imagination,
confident in faith,
and courageous in our engagement
with the people and places of this diocese.
As we share your life with the world,
keep us rooted and grounded in love
as we bear witness to your glory
and pray for your Kingdom to come.
New people are always welcome at our services, whether you are just popping in, a visitor, or giving church a try. We aren't a membership organisation, there are no qualifications for entry, anyone can share worship with us in whatever way they are comfortable with.
Our next Sunday service is:
Holy Communion
9.30am Sunday 5th January
By the time residents of Cromhall and surrounding areas read this, there will have been a public meeting to discuss the future of the church building and hopefully,come up with fund raising ideas for the substantial sum of money required to ensure that the church is kept watertight and operational for all residents of Cromhall, both present and future. I sincerely hope that this was well attended and that all residents of the parish are now aware that our very beautiful and historic Grade 2 listed church is in need of a lot of TLC and support from everyone who wants it to remain as an important part of our village life, whether they are part of the congregation or not.
The 100 club is a major part of our present fundraising operation with no overheads apart from the prize money we pay out. This means that most of the money paid in goes straight into church funds and is an incredibly easy way for everyone in Cromhall to contribute to the maintenance of the church building and churchyard.
A mere £10 per number ( we have never increased the amount since the club started) will ensure entry into 6 draws a year: Christmas, February, Easter, May, August and November and the chance to win £50 at Christmas and Easter and £30, £20 and £10 on the four other draws. We collect the subscriptions mainly in the Village Shop from the beginning of November but you can also post them through my door at Ashleigh, Cowship Lane or contact me on 294186 if you have any queries about the 100 club.
I always struggle to fill all the numbers and last year there were still 7 not taken, even though it works out at about 84p per month. That's only 84p per month for 14 chances to win some cash and support a treasured village landmark, a win win situation in my opinion!
Sincere thanks to all our loyal supporters and I look forward very much to welcoming lots of new contributors.
Thank you very much, Mandy Bird.
PS The fliers for 100 club renewal went into the 5Alives a month early so if you still have Octobers copy, you ll find the renewal form in there.
St. Andrew's CE VC Primary School


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The Autumn 2019 Issue of Nutraceuticals Now is now available.
Excerpts of featured articles are available on this website:
To download a PDF of this issue, please subscribe to Nutraceuticals Now or login to your account.
Nutraceuticals NOW – Latest information on disease preventing and/or health promoting nutritional foods and ingredients
Almonds: A Healthy Snack and Ingredient Option.
Almonds offer a variety of nutritional benefits. A
1-ounce (28.35 g) serving of almonds contains 6
grams of protein, 3.5 grams of dietary fiber, 76
milligrams of calcium. All values deliver more
nutritional benefit than other tree nut. Almonds are
an excellent source of Vitamin E, providing 35% of
the recommended Daily Value. Although a serving
of almonds contains 14 grams of fat, the majority
(9 grams) is monounsaturated fat.1
Consumer interest in healthy snacking has
increased in recent years. Fortunately, there have
been several scientific studies conducted linking
almonds to health benefits. The Almond Board of
California has been instrumental in delivering the
message of almond benefits.
Almonds are high in monounsaturated fats, which have been
associated with reduced risk of heart disease. Clinical studies
have found that almonds consumed regularly as part of a
diet low in saturated fat can help maintain healthy cholesterol
levels. Almonds (nuts) are one of a handful of qualified health
claims allowed in the United States. The claim states: "Scientific
evidence suggests but does not prove that eating 1.5 ounces
per day of most nuts, such as almonds, as part of a diet low
in saturated fat and cholesterol may reduce the risk of heart
disease." Almonds are a healthy snack and when incorporated
into a healthy, balanced diet, the benefits are maximized. The
ability of almonds to reduce the risk of heart disease may also
be somewhat due to the antioxidant action of vitamin E in the
almonds in addition to the LDL-lowering effect of almonds'
monounsaturated fats.2 According to the Mayo Clinic, "studies
show that eating foods rich in monounsaturated fats (MUFAs)
improves blood cholesterol levels, which can decrease your risk
of heart disease. Research also shows that MUFAs may benefit
insulin levels and blood sugar control, which can be especially
helpful if you have type 2 diabetes." 3
Almonds have a positive impact on factors related to diabetes.
Reducing after-meal increases in blood sugar helps protect
against diabetes and cardiovascular disease. Almonds appear
to not only decrease after-meal increases in blood sugar, but
also supply antioxidants to clean up the smaller amounts of free
Including raw almonds as part of a healthy diet may help prevent
weight gain. Almonds contain three grams of dietary fiber of
which 0.5 g is soluble fiber.1 Several studies have found that
nuts, including almonds, can play a role in weight maintenance.
Almonds are a high satiety food that are slowly metabolized by
the body due to relatively high fiber content. The fat and protein in
almonds promote satisfaction as well.5
Scientists have determined the concentrations of antioxidants
(phenols, flavonoids, and phenolic acids) in almond skins and
almond kernels using high-performance liquid chromatography
(HPLC)/electrochemical detection, UV detection, and mass
spectrometry. They found that almonds contain flavonoids and
phenolics in their skins comparable to fruits and vegetables that
are well known for high antioxidant levels. The study authors
concluded that a one-ounce serving of almonds contains a similar
amount of total polyphenols as one cup of green tea and cup of
steamed broccoli.6
A 2012 study published in the American Journal of Clinical
Nutrition found that almonds may have fewer calories than
originally thought. The objective of the study was to compare
energy value of almonds in the human diet to values determined
by the Atwater factors. The study concluded that energy content
of almonds in the human diet was 129 calories per 28 g serving,
much lower than the 170 g per serving calculation from the
Atwater factors.7
The numerous health benefits associated with almonds combined
with the wide array of forms that almonds are available make them
the perfect ingredient for numerous applications.
Offerings of flavors add innovation to the market. Whether
whole, sliced, slivered or diced, almonds can carry a flavor profile
when used as a primary ingredient. The versatility of almonds
comes through because of the breadth of flavor possibilities
available for almonds.8
Almonds are well suited to a wide array of applications with the
addition of texture and visual appeal to food products. Almonds
lend themselves to both sweet and savory applications. Available
in an array of forms: whole, sliced, diced, slivered, flour, natural,
blanched, paste, butter. There is an almond form suitable for any
imaginable application.
A Healthy Snack and
Ingredient Option
By Jennifer Eastman
Senior Food Scientist
Blue Diamond Almonds
Confections – The versatility of almonds is able to stand
out in the confectionery industry. Whole almond tend to be
used in either chocolate bars or panned candy products such
as an almond with a flavored, hard candy coating or sugar
coating. Sliced and diced almonds would typically be found in
bars or enrobed products and almond paste or almond butter
can be used as a base for a filling or as a stand-alone filling
for chocolates. Almonds fit very nicely into today's trends in
confectionery. Research indicates that consumers want to
be able to justify a chocolate indulgence. Almonds can add
texture and enhance nutrition when used as an ingredient in
Baked Goods – Almonds make baked goods pop. From
bear claws to cookies to cakes and pies, almonds are the most
popular tree nut utilized in bakery products. Almond flour is
often utilized in gluten free baking applications, as a blend of
other ingredients such as rice flour, tapioca starch and potato
starch to substitute for wheat flour.
Cereal – Almonds outscore other nuts on two key attributes
consumers say they are looking for when choosing breakfast
products: "is tasty and nutritious" and "fills me up until
lunch."9 The form of almond utilized in cereals depends on
the bulk density of the cereal. For example, the best form for
flaked cereal is almond slices whereas for granular type cereals
diced almonds would function best. Slivered almonds make an
interesting inclusion in cereals as well.
Granola and Nutritional Bars – Almonds offer an excellent
texture and visual enhancement to food bars.
Snacks – Almonds are an attractive snacking option to due
to their health benefits. Almonds can be a standalone snack, or
used in trail mix and clusters.
Ice Cream – Almonds and ice cream are a classic
Yogurt – Almonds have recently found their way into the
yogurt aisle as a stir-in to enhance the textural attributes of
yogurt and increase a products premium presentation.
Prepared Foods – Almonds can be utilized in many prepared
food applications. Examples include sprinkling on green beans,
as a coating for chicken and fish and toppers for pasta and
The healthy benefits of almonds make them an excellent
choice for snacking on their own as well as using them in the
formulation of food products to make them more enticing to
consumers from both visual and nutritional standpoints.
Works Cited
1. USDA National Nutrient Database for Standard Reference,
Release 26, 2013.
2. Berryman CE; Preston AG; Karmally W; et al. Effects of
almond consumption on the reduction of LDL-cholesterol:
a discussion of potential mechanisms and future research
directions. Nutrition Reviews. 69 (4): 171-185.
3. "Nutrition and Healthy Eating." By Mayo Clinic staff.
"MayoClinic.com." Accessed October 3, 2013.
4. Jenkins DJ and Kendall CW. Possible benefit of nuts in
Type 2 diabetes. Journal of Nutrition. 138(9): 17525-17565.
5. Mattes RD and Dreher ML. Nuts and healthy body weight
maintenance mechanisms. Asia Pacific Journal of Clinical
Nutrition. 2010; 19(1):137-41.
6. Milbury PE, Chen C, Dolnkowski G, Blumberg J.
Determination of Flavonoids and Phenolics and their Distribution
in Almonds. J. Agric. Food Chem. 2006, 54,5027-5023.
7. Novotny JA; Gebauer SK; Baer DJ. Discrepancy between
the Atwater factor predicted and empirically measured energy
values of almonds in Human Diets. The American Journal of
Clinical Nutrition. 96(2): 296-301.
8. "Snacking drives nut-based confections." Schuul, CZ.
"CandyIndustry.com." Accessed October 2, 2013.
9. Healthy Men Ingredient Why and Jane Ingredient Why.
Sterling-Rice Group. 2010


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School Challenge: Buggies, Bridges and Baddies
Key info
- 3-hour session in Eden Project outer estate
- Suitable for years 4 – 6
- £8.40 per pupil
- Available for June and July
Can you save the universe from a water crisis? It's a Space Age race against time across a dry and dangerous planet to reach the rocket launch pad and beat the Buckethead Baddies.
School trips to Eden
Find out why students and teachers enjoy their educational trips to Eden so much!Play video
Activity overview
This challenge is written to highlight the importance of water and its link to life on earth, but in a very silly way.
Your mission is to rescue our water, the universal key to life, before the Buckethead aliens find out. However, once the alarm has been raised it's a race against the clock to cross the swamps, build your buggy and drive it through their planet to escape.
If you make it (unlikely!) you need to build a rocket and fire your precious water safely back to earth before you get caught.
Teams will have to think together and solve problems quickly in a variety of situations.
They will have to plan ahead, consider the consequences of their actions and learn by their mistakes.
Each team will design and build simple structures and vehicle from basic materials.
Teams will consider risk and safety and be expected to look after the whole team.
Discuss the importance of water to life and natural processes (Geography and Science)
Practical information
- A facilitated 3-hour session with our Education Team
- All equipment needed to complete your challenge.
- All activities fully risk assessed.
- Eden Challenges cost £8.40 per pupil, with a minimum charge of £168 per group (includes VAT).
Book your stay
Book your room and board via the schools section of the YHA's website. Contact Eden for availability of our Workshops, Challenges or Evenings, via our online enquiry form.


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Does your family have rules? I'm tempted to keep this card and frame it- I love the gentle reminder of how we should act!
This card is an oversized 5.25 x 6.75 size Greeting card. Useful for any occasion & blank inside for your message.
Each of my cards is made by me personally! My creative inspiration strikes randomly & comes from all sorts of places. I rarely make more than one of each card.
Cards come with an envelope, (occasionally I need to make my own envelope because of the card size).
Each card is protected within a cellophane sleeve.
I consider each card a gift from the ❤.
Please share my cards with everyone in your life.
Direct Checkout- most major Credit cards accepted.
Items will ship the next business day after you place your order.
But please contact me if you have any problems with your order.
Because of the nature of the item -All sales are final however 100% customer satisfaction is my goal. If there is a problem with the item please contact me, we can work out a resolution.
My cards are unique and are all Handcrafted. I use crafting supplies from a plethora of companies current and vintage items.
I will not share your information with anyone!


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- This event has passed.
Bubbles & Brunch
Saturday, October 7, 2017 at 7:00 am - 9:00 am$50
Wake up and enjoy a five course brunch at Altea's Eatery in Worcester. Altea's will be creating a five course brunch focused on thoughtfully sourced, honest American food with a French twist in a modern and comfortable space. Owned by Oriola Koci and Chef Enton Mehillaj, Altea's is the couple's second restaurant which opened in 2016. The Signature Wine Brunch will start with spiced sugar beignets and granola and move into a frittata and croquet monsieur before ending with a decadent crêpe—each paired with carefully selected wines to bring the total experience together. (Finalized menu will be listed shortly.)
Ticket is inclusive of food, beverage, gratuity, and tax.
Who's Attending
13 people are attending Bubbles & Brunch


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Lucky Card Deck
Played 1396 times
Lucky Card Deck game information:
Lets meet the character of this game. He is quite passionate poker player that known much about the game. He has lost his favorite deck of cards, and now he thinks that he wont have any luck in future. Are you willing to help him?
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Day: August 12, 2019
FOSCOR Debut "Cançó de Mort" Music Video FOSCOR Debut "Cançó de Mort" Music Video Catalan atmospheric metal band, Foscor, have premiered a video for "Cançó de Mort", a song from their upcoming release, Els Sepulcres Blancs, out on September 6. Watch the clip below. Tracklisting: "Laments" "Els Colors del Silenci" "Malson" "Secrets" "Cel Rogent" "Canç…. […]
'Shot of Love' was the last installment of Bob Dylan's "born-again" trilogy. How Bob Dylan Began His Next Transition on 'Shot of Love' Bob Dylan released 'Shot of Love' on Aug. 12, 1981. [post embed] Source = click here: https://www.facebook.com/107710719302307/posts/2971576036249080
12th August 1927, born on this day, Porter Wagoner, Country singer known for his flashy Nudie and Manuel suits and blond pompadour. In 1967, he introduced a then little known Dolly Parton on his long-running television show. Also known as Mr. Grand Ole Opry, Wagoner scored over 80 US Country singles from 1954–1983. He died […]
Happy 70th birthday to Mark Knopfler! Top 10 Dire Straits Songs A list of the very best songs by Mark Knopfler and Dire Straits. [post embed] Source = click here: https://www.facebook.com/107710719302307/posts/2971521092921241
JOHN 5 Talks New ROB ZOMBIE Album – "It's Heavier Than Any Of The Other Records, With More Melodies"
The Beatles hired Pete Best as their new drummer on the eve of their first Hamburg residency. The Day Pete Best Joined the Beatles The Beatles hired Pete Best as their new drummer on Aug. 12, 1960, the eve of their first Hamburg residency. [post embed] Source = click here: https://www.facebook.com/107710719302307/posts/2971538126252871


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w h o t e l l t h e
Models of Courageous Citizenship
A month long
community engagement project
in Ipswich, Massachusetts
July 1 – 29, 2019
Thank you!!
The Americans Who Tell the Truth organizing committee would like to thank the Ipswich community for their support and participation in the events based on the portraits of artist Robert Shetterly. Our goal was to foster community engagement and civil discourse based on courageous citizens who exhibited moral courage. The month of July saw the exhibit and associated activities throughout our town. We thank the Ipswich community and our sponsors for their support and look forward to continued work with the Americans Who Tell the Truth project in the future.
Until next time, The AWTT Organizing Committee
"When people work together things change for the better"
Florence Reed, Environmental Activist


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Today's Dubai Airshow was hectic for members of the media. Press conferences were being moved around like they were going out of fashion. However, it wasn't all bad news, because there were plenty of order announcements. Let's take a look at the highlights!
Air Astana's Boeing 737 MAX Order
For me, today's star order was Air Astana's Letter of Intent for 30 Boeing 737 MAX aircraft. The agreement will see Air Astana potentially order 30 Boeing 737 MAX aircraft for its LCC subsidiary, Fly Arystan. With deliveries set to commence in 2021, it seems like Air Astana has secured a place within the existing aircraft queue. However, by placing an order for the 737 MAX, we have seen the airline express confidence in the aircraft.
Air Senegal's Airbus A220 order
Shortly after Air Astana's order, the press assembled in an Airbus press conference. Here it was announced that Air Senegal would place a memorandum of understanding for eight Airbus A220-300 aircraft. The order would be firm, with no options. During the press conference, Air Senegal's CEO, Mr Ibrahima Kane, said that due to the flexibility of the aircraft, it could be deployed from Dakar on routes ranging from Lagos to London.
Flynas firms 10 Airbus A321XLR orders
Saudi Arabia's first low-cost airline, Flynas, firmed up an order for 10 Airbus A321XLR aircraft. The airline currently has 80 A320neo family aircraft on order. In addition, it currently operates a fleet of 27 A320ceos and 4 A320neos.
Featured Video:
GECAS orders 32 Airbus
Slightly later in the day, we saw GECAS order 32 Airbus aircraft. This consisted of 20 Airbus A321XLRs, which were announced at the Paris Airshow, alongside twelve Airbus A330neo aircraft. As the aircraft leasing arm of General Electric, GECAS won't operate the aircraft themselves, but will rather lease the aircraft to other airlines.
Ghana's three Boeing 787s
Heading back to Africa saw Ghana order three Boeing 787s. While the press conference was due to start at 10 o'clock, the order announcement was delayed until later in the day. This was put down to a delay at Dubai Airshow's security.
A Memorandum of Understanding was today signed between the Ghanaian Government and Boeing for three Boeing 787-9 aircraft. The aircraft will be used to relaunch Ghana Airlines, with Joseph Kofi Adda, the Ghanaian Minister of Aviation, saying: "We believe the advanced 787-9 Dreamliner gives us an efficient and flexible machine to launch a regional network and eventually serve international destinations in the future."
What's in store for tomorrow?
Tomorrow is the penultimate day of the Dubai Airshow. The weather is set to take a turn for the worse, with rain forecast from seven in the morning until nine at night. So far Emirates has confirmed a press conference at 11:00 tomorrow. What this will be regarding is currently under tight wraps. However, there are likely to be more events announced throughout the day.
What was your highlight of Dubai Airshow Day 3? Let us know in the comments!
2 Leave a Reply
Anyone ordering B737 Max 8's Could be considered as having "confidence in the model" .?
Or they could be considered to be desperate for delivery-slot…..
2021 is a stupidly short delivery slot for a brand new order….. Which would imply that other airlines have cancelled.?
Additionally, we've no idea at all how much Astana are paying for these airframes.?
Maybe Boeing are doing a BOGOF deal, or better.?
Maybe there simply giving some away to smaller buyers, in order to try to create market confidence.?
Airbus has a backlog of nearly 7000 A320 series orders and its production rate is around 60/ month or 720 or so per year. The wait list on the surface is nearly 10 years. I know Airbus is working on increases in production. It suspect it may get to 100/month with 10 from Tianjing and 8 from Mobil.


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Year 12 | 19 January 2020 | firstname.lastname@example.com
Million Trees is organizing a "Trees for Bees" forage-planting event to take place October 27th at historic Floyd Bennett field from 9 a.m.- 1.p.m. You must register in advance. The purpose of the planting is to promote critical plantlife resources to encourage healthy bee populations for pollination and honey production. Planting supplies, a lunch, a honey-tasting, and a guided hike will all be provided by Million Trees.
MillionTreesNYC, one of the 132 PlaNYC initiatives, is a citywide, public-private program with an ambitious goal: to plant and care for one million new trees across the City's five boroughs over the next decade. By planting one million trees, New York City can increase its urban forest—our most valuable environmental asset made up of street trees, park trees, and trees on public, private and commercial land—by an astounding 20%, while achieving the many quality-of-life benefits that come with planting trees.
The City of New York will plant 70% of trees in parks and other public spaces. The other 30% will come from private organizations, homeowners, and community organizations.
by S. C.
15 october 2012, World News > America


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Platteville, Wi USA
Phone: 888-660-7125
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