text:
Doctor insights on:
How Can You Tell The Difference In Anal Cancer And Hemorrhoids
How can you tell the difference in anal cancer and hemorrhoids?
Not always easy at: First, but unless the hemorrhoid is thrombosed, it usually reduces and eases with sitz/tub soaks, preparation h. Both are painful, the anal canal is inside the opening, and the rectum above. Both can be quite painful, external, and bleed. An expert needs to decide when to look higher and biopsy. Also, nodes in groin. Get a surgeon to help. ...Read moreSee 2 more doctor answers
Cancer (Definition)
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
How can you tell the difference in hemorrhoids and anal cancer?
Examine: See a doctor for an examination. Hemorrhoids are soft purplish veins under the skin. Anal cancer is a rare condition and would be a firm process in or on the surface of the anal skin. Might be difficult to see on your own self examination. ...Read more
How can you tell the difference between hemmerhoids and anal cancer ?
See a doctor...: For an exam. You cannot see the area to tell. Generally a hemorrhoid will be soft & raised & maybe slightly tender. Anal cancer would be more flat & firm and generally not sore. Anal cancer much more rare too. But needs an exam by a doctor to tell. ...Read more
How do you tell the difference between anal fissure and anal cancer?
Biopsy: Evaluation by GI and possible biopsy for diagnosis. ...Read more
Hemorrhoids or anal lump--how can I tell the difference?
You can't: Anal lump can be a complication of hemorrhoid called a thrombosed hemorrhoid, it could be a cyst, skin tag or a papilloma. ...Read more
How can you distinguish between the symptoms of hemorrhoids and colon cancer?
Hemorrhoids are anal: When hemorrhoid are symptomatic they thrombose, causing anal pain or bleed locally. Colon cancer, due to a lesion in bowel if localized can cause blood mixed in stool or obstruct causing abdominal discomfort and distention ...Read more
How can you tell the difference between hemorrhoids and skin tags?
Hemorrhoids: Hemorrhoids are usually ingorge blood vessels that can get bigger and smaller. They can bleed, cause pain and irritation and discharge. Skin tags usually stay the same size and don't cause any symptoms. ...Read moreSee 2 more doctor answers
Can you tell the difference between prolapsed rectum and hemorroids by sight?
Yes: A prolapsed rectum wil show concentric rings which are the mucosa, or inner lining, of the rectum. Hemorrhoids are a triangle or star shape and are basically bulging veins. The trained eye can easily distinguish these. See your doctor ...Read moreSee 1 more doctor answer
Can you tell me how haemorroids form in rectum area and what causes them to bleed?
Protruding: The anal tissue and the local veins are pushed out and expand over time and pressure. Dry hard stools and constipation are elements of the problem. The anal mucosa over the protruding veins is delicate and if rubbed, wiped too hard will ooze or bleed. If the veins are exposed, significant bleeding can occur. ...Read more
Wouldnt a GI doc be able to tell the difference in anal cancer and hemorrhoids?
Yes: And or surgeon.Get a more detailed answer ›
How can you tell the difference between testicular cancer and just epyditimitis?
Pain, tenderness.: Usually, epididymitis is painful while testicular cancer presents classically with a painless mass. Fever, tenderness and swelling can also be present. The major cause in heterosexual men < 35 years old is chlamidya trachomatis, accounting for 70% of cases. A course of appropriate antibiotics clears it up. Testicular cancer can be worked up by taking AFB and b-hcg levels, chest x-ray, and ct. ...Read moreSee 1 more doctor answer
How to tell the difference between a anal fissure and hemroids?
Anal Fissure: An anal fissure is like a cut. Hemorrhoids are distended veins at the anus. Both of these hurt very much. A physical exam by a physician would be best if you have never been examined for this. ...Read more
Would an obgyn be able to tell the difference in anal cancer and hemorrhoids?
Yes, maybe not: The exact cell type, but these are two different diseases. ...Read more
Can you tell me how is rectal cancer affected by stool?
Rectal cancer: Cancer is very fragile. Anything hard enough rubbing on the cancer can cause bleeding. If one has rectal cancer- it can cause blockage / cause constipation/ change in bowel movement. And if a hard stool rubs on the large cancer tissue-the stool may cause the cancer to bleed. ...Read more
Can you tell me how one go to the restroom (#2) with an anal fissure?
Keep stool soft: Drink plenty of water, take fiber, avoid acidic foods like citrus and tomato products. Mineral oil by mouth can ease the passage of stool. Using a numbing cream like Dibucaine ( needs Rx) can help. ...Read more
Can you tell me how do men get breast cancer and where on that area does the cancer form?
Uncommon but occurs: Male breast cancer is most common in older men, though male breast cancer can occur at any age. Although the incidence is 1/100 less frequent than women, the presentation is the same, usually a small mass under the nipple. Risk factors for male breast cancer include exposure to radiation, a family history of breast cancer, and having high estrogen levels. Treatment entails removal of the breast. ...Read more
How can haemorroids form in rectum area and what causes them to bleed?
Pressure and trauma: Hemorrhoids are enlarged veins that exist under the lining of the rectum and anus. The primary cause of hemorrhoids is increased abdominal pressure, from chronic constipation, prolonged sitting, pregnancy and in some cases, from other diseases, such as liver disease. They are usually fleshy and soft but cause discomfort when engorged and bleed with trauma such as passing hard stool or hard wiping. ...Read more
How can you tell the difference between melanoma, the other skin cancers, and moles/scabs?
Skin exam/biopsy: A dermatologist can recognize the difference between these in many cases just off of a skin exam. If they still have a concern/suspicion, a biopsy can be performed to definitively identify the lesion. ...Read moreSee 1 more doctor answer
What can you do to tell the difference between a oral ulcer and oral cancer?
Oral Cancer: The only way to know conclusively whether or not a lesion is cancerous or not is by having the area biopsied and sent for microscopic evaluation to a pathologist. While most ulcers are gone by two weeks, there are some types of ulcers that last longer but are not cancerous. Some cancers do not ulcer. Start by seeing your dentist or an oral surgeon for an evaluation and diagnosis. ...Read moreSee 1 more doctor answer
How can I tell the difference between radiation cystitis and spread of my cancer to the bladder?
Cystoscopy + biopsy: Urine can be sent for cytology to see if there are any cancer cells present. More definitive is by cystoscopy and biopsy of any suspicious lesions in he bladder. ...Read moreSee 3 more doctor answers
Anal Cancer (Definition)
The anal canal lesion is squamous in origin. The dentate line marks the upper junction between squamous and mucosal epithelium in the anal canal. ... Tumours near the anal margin spread to the inguinal lymph nodes; those higher in the anal canal spread to the pelvis The Anal Cancer Trial (ACT-1) demonstrated the superiority of using chemoradiation with 5-FU ...Read more
Anus (Definition)
The anus is the opening of the rectum, through which stool and flatus are passed. The anal canal is about an inch in length, and is ...Read more
- Talk to a doctor live online for free
- How to tell anal cancer from a hemorrhoid?
- Wouldnt a gi doc be able to tell the difference in anal cancer and hemorrhoids
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- Ask a doctor a question free online
- How can i tell the difference between a hemorrhoid and an enlarged prostate?
- Pleurisy or pericarditis how can you tell the difference
- Can you enjoy anal sex if you have hemorrhoids?
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subset: commoncrawl


text:
Holy Trinity Tiny Tots Preschool
39020 5 Mile Rd
Livonia, MI 48154
Phone: 734-464-0256
E-mail: email@example.com
Please call us at:
or fill out our contact form.
Tiny Tots Preschool
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text:
Monday, November 16, 2009
Tian Men Shan (天门山) @ Hunan (湖南), China
5 comments:
Scenic spots within Tian Men Shan or the province of Hunan?
Unfortunately, i spent only four hours at tianmenshan and the time is barely enough to explore further.
- Anonymous9:24 AM
scenic spots within tianmen shan..btw, u managed to spend 4 hrs??? wow!!!!!ReplyDelete
managed? 4 hours are too short!ReplyDelete
if you could afford the time, you should stay longer and explore the other scenic spots of tianmenshan.
from what i remember; they have this temple, which can be seen from the elevated ling xiao platform.
With clouds surrounding the temple, it looked as if it belongs rightfully to heaven.
there's another interesting area i noticed on the map called ghost valley or something. the limited time meant that i did not even have a chance to see how it looks like.
seriously, do consider staying longer to explore the area in a more relaxed manner. :P


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What is another word for soggy?76 synonyms found
Pronunciation:[ s_ˈɒ_ɡ_ɪ], [ sˈɒɡɪ], [ sˈɒɡɪ]
Table of ContentsSimilar words for soggy:
- clammy (adjective)
- damp (adjective)
- damp or soaking (adjective)
- heavy (adjective)
- pulpy (adjective)
- saturated (adjective)
- soaked (adjective)
- sultry (adjective)
- watery (adjective)
- wet (adjective)
- other synonyms
Definition for Soggy:
Synonyms for Soggy:
adj.•clammy (adjective)
- drizzliest,
- slimier,
- most mucid,
- more mucous,
- most muculent,
- drizzlier,
- more muculent,
- pasty,
- most mucous,
- more mucid.
- most dripping,
- more soaking,
- more wettish,
- most drenched,
- more dripping,
- mis-tier,
- most soaking,
- most irriguous,
- more irriguous,
- mis tier,
- most wettish,
- more drenched.
- more wringingwet,
- more wringing-wet,
- most wringing-wet,
- Water-logged,
- more wringing wet,
- wringingwet,
- more water logged,
- most wringingwet,
- water logged,
- wringing wet,
- most water-logged,
- most wringing wet,
- most water logged,
- more water-logged.
- more smothering,
- red hot,
- sweltry,
- most suffocating,
- more suffocating,
- sweltrier,
- sweltriest,
- most smothering.
- hot.
Other synonyms:
- soppy.
Antonyms for Soggy:
damp or soaking
arid, dry, dehydrated, hard, cool.
Other antonyms:
water-resistant, sunbaked, thirsty, water-repellent, light, baked, watertight, waterproof, parched, active, Wrung, freeze-dried.
- damp or soaking
Other antonyms:
dry out.
- n.
Soggy Sentence Examples:
The soggy, mossy path made heavy travelling for weary, nervous feet, but at the foot of the hill Priscilla saw the little canoe bobbing at the side of the dock.
Get off your soggy butt and start taking control of the situation.
Homophones for Soggy:
- squeaky, schwa, schizaeaceae, Seiji Ozawa, 1900s, sage, showy, sauk, sequoia, shaw, soak, soy, 1760s, shiah, shikse, sise, shwa, sickish, schizaea, siege, squeegee, soya, swishy, swag, seek, skyhook, sou, sock, saiga, sewage, 1930s, sis, sky, sissoo, 1780s, sika, SSA, swage, soy sauce, sea, sissyish, sea cow, sexy, sue, sack, 1880s, Sacajawea, succuss, SAS, sissy, shikoku, shako, 1970s, sukiyaki, sky-high, shogi, 1860s, scoke, sw, squeak, ss, sugi, so, siss, 1530s, saga, 1770s, success, show, squish, sic, Sousse, skyway, swazi, sex, 1950s, 1960s, sass, skyjack, sway, squawky, squishy, sake, sheikh, say, shay, scag, shush, 1890s, shake, sa, 1840s, Skaw, sick, ski, squashy, shack, ski wax, sagacious, sissu, segue, si, syzygy, Skag, sushi, such, suck, Swaggie, se, skew, sigeh, sea ash, six, sac, 1830s, seize, sussex, schweiz, saucy, scsi, so-so, suisse, see, sizz, sash, squeeze, sow, S, suez, sse, sequoya, 1990s, seiche, soakage, squaw, shia, 1920s, sikh, shoji, skua, sc, saki, sag, sausage, SG, swoosh, size, shaggy, ssw, shoe, seaway, sick joke, showcase, souk, succos, squasy, sassy, seasick, shoo, sioux, swash, scow, sax, socage, shua, shoes, sheika, seesaw, Susa, squash, sockeye, swiss, shuha, swosh, 1790s, saw, SSS, sew, sacagawea, shew, sacque, soho, soja, shaky, sequoyah, shag, 1820s, skagway, soh, shiksa, 1940s, swiz, swish, squawk, sos, she-oak, sheesha, scouse, sacco, sec, sus, saek, sashay, 1980s, sheik, succus, shucks, sheikha, shock, segway, 1870s, 1850s, souse, sauce, sago, sigh, schuss, swig, shook, say-so, sousa, sough, shoo away, sess, shuck, Swiss Cheese, shah, shy, Susah, shisha, skeg, 1750s, seaquake, saxe.


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CNOC Manager
CNOC Manager
Splunk Cloud is looking for a Manager to provide day-to-day leadership to our cloud operations center (CNOC). This position is responsible for the Incident management process design and continuous service improvements as necessary to achieve the objectives of the business. As manager of the Cloud Ops Center, you'll lead a team responsible for the 24/7 support and monitoring of our rapidly growing Cloud Platform. You'll utilize analytics to plan, implement and continually improve processes that lead to an improvement in overall MTTR. We're looking for someone to bring a fresh approach to problems of all shapes and sizes and help us build a best-in-class Cloud Operations Center.
- Solve issues and participate in on-call support, ensuring stability and performance of the Splunk Cloud environment.
- Partner with our SRE teams to deliver agile, highly automated capabilities to monitor applications and our cloud infrastructure.
- Drive automation (of runbooks) and software-defined approaches to reliability and availability as well as change management.
- Work Closely with various groups within Operations to drive efficiencies. Including authoring of runbooks and key alert metrics, and overall health and stability of monitoring.
- Represent the Cloud Operations Center in meetings/process changes and make recommendations on new procedures/ processes.
- Work with your peers across the organization to handle related or dependent release activities.
- Act as a Liaison between SRE, monitoring teams, support and leadership for new processes, tools and knowledge transfers.
- Oversee all Cloud Operations Engineers and leads and ensure all duties and tasks are being performed expertly and effectively during each shift.
- Mentor and coach new team members
- Provide Incident commander responsibilities, contribute to post incident review, and follow through with action plans
Who you are:
- 2-4 years in hands-on manager position.
- Deep understanding of Cloud (AWS, Azure, GCP).
- Experienced in Systems Administration or Technical Operations
- Hands-on experience maintaining and troubleshooting Linux/UNIX servers in a production environment.
- Strong knowledge of and experience with Config management
- Collaborative with exceptional social and interpersonal skills.
- Calm and collected in stressful situations, such as a major service outage.
- Take charge personality, and the ability to drive a plan to completion.
- Comfortable working in a dynamic environment with a highly technical team.
- Demonstrated attention to detail, follow through, and ability to prioritize quickly are necessary.
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Thank you for your interest in Splunk!
Splunk's Hiring Practices
Splunk turns machine data into answers. Organizations use market-leading Splunk solutions with machine learning to solve their toughest IT, Internet of Things and security challenges.
Individuals seeking employment at Splunk are considered without regards to race, religion, color, national origin, ancestry, sex, gender, gender identity, gender expression, sexual orientation, marital status, age, physical or mental disability or medical condition (except where physical fitness is a valid occupational qualification), genetic information, veteran status, or any other consideration made unlawful by federal, state or local laws. Click here to review the US Department of Labor's EEO is The Law notice. Please click here to review Splunk's Affirmative Action Policy Statement.
Splunk also has policies in place to protect the personal information candidates disclose to us as part of the application process. Please click here to review Splunk's Career Site Privacy Policy.
Splunk does not discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. Please click here to review Splunk's Pay Transparency Nondiscrimination Provision.
Splunk is also committed to providing access to all individuals who are seeking information from our website. Any individual using assistive technology (such as a screen reader, Braille reader, etc.) who experiences difficulty accessing information on any part of Splunk's website should send comments to email@example.com. Please include the nature of the accessibility problem and your e-mail or contact address. If the accessibility problem involves a particular page, the message should include the URL of that page.
Splunk doesn't accept unsolicited agency resumes and won't pay fees to any third-party agency or firm that doesn't have a signed agreement with Splunk.
To check on your application click here.


text:
Well yes, lockers only get you stuck further, but handy none the less.
Land cruiser and unimog, dominate on so many levels. Wish I had a unimog to go alongside my cruiser.
You guys eat liver, kidney or heart?
I wounder if a 12 gauge shotgun loaded with WW .690 RB at 1600 fps counts?
If not, I suppose I will just have to wait untill I build my for 458 to...
I concur with 35bore.
72 C for two minutes kills all nastys.
Who is looking down on big bore catridges?
I've eaton cougar it was delicious.
Megaloceros giganteus
Mossberg actions are pure genius.
All the gear, but no idea!
Oops sorry, just thinking aloud.
Not becuase they are very inexpensive but because they work. The rings secure the scope to the picatinny rail with confidence, the quick release...
I'm sure hitting buff in the toe with a 500 NE, will not make him crumble into a thousand pieces.
I say hunt with whatever you're comfortable with. For me it would the 375 handh or a 458 win mag, only because of ammo availability and the retail...
I use the TKF, but it's sujective for many.
Sounds good to me.
Why bigger than a .375?
Just curious .... :)
Yes, I agree with Simon.
Good for you.
The only thing you will loose is availability.
Ruger seems to reinvent and improve the wheel with the 375 ruger and 416 ruger.
I guess, good things come in smaller (shorter) packages.
Leatheman surge in my pants pocket.
On my hunting pack an 18 in tramontina machete and a mora knife.
Some nice cruisers there.
I am a proud owner of a
1986 Toyota Bj74 turbo diesel Land cruiser
Winched, lifted and locked
Australian Rodney...
Make sure to give lots of room around the trigger safety mechanism.
Very important.
It's very personal thing when you buld your own rifle.
Here is what works for me in my very simple builds.
Boyds or equivalent laminated stock,...
Oh, just one other thing.
A thumb smasher. ;)
sterile water
first aid (D ABC RBS)
insect repellent (deet)
Remember, the best...
Boyds thumbhole is what I have on my 30-06, I really like it.
Thanks Longwalker
I think l will stick with my mossberg.
I must admit I do an excellent fish and chips, I use my own homemade beer batter. Served with sea salt, malt vinigar, mushy peas and pickled...
I see, excuse my ignorance. I had to wiki to find out the meaning of "tautology". Thanks for your replie.
The spine and the vitals are not nessarilly exclusive in a shot.
Gentlmen we have to somewhat agree to differ, thank you all for your generous...
I have read that a shot to the spine is very humane, the trauma to the spinal cord sends messages directly to the brain causing a...
I have made the shot on deer and bear when the situation lends itself to accurate placement. I hunt alone and I like to keep my recovery to a...
Sadly I can not speak of Africa ...
The vitals should always take a hit, spinal or not. With a good spine shot you can do both.
So when winchester advertise there pump as having a "ROTARY BOLT with four massive lugs provides strength and solid lockup", it's an inaccurate...
Between the shoulder blade and the spine, usally makes them crumble on the spot. Saves on blood tracking.
What do you think?
70 series land cruisers - rule
Or maybe not.
Your opinions please.
Shelf ammo, federal blue box.
So easy to reload you should learn, it will change your accuracy for the better.
Curry and Guinness.
Don't know about what Courtney says, but I like mink oil for -40c to plus 40c.
Mr P, I'm digging your wonderful work.
I have noticed that winchester and benelli are using a rotary bolt design on there pump action shotguns, just curious for your opinions on the...
I advise a one piece picatinny base with quick release scope rings. JB weld and red thread lock the screws to the scope base and the receiver and...
I just wanted to add that at heart I'm a meat hunter, tho I do understand the conservation side of trophy hunting and I am in full support of it.
Then start with the hornady minimum load. And pull the trigger with a long peace of string. ;)
Don't know fore sure, it could be case capacity and bullet seating.
But keeping bullet weight the same, physics surgests you should be fine,...
Yes, I will let you know.
Separate names with a comma.


text:
The personal narrative of a woman who worked at the Muesam of Jewish Heratige and felt out of place before adopting a Jewish lifestyle.
She was happy to take her recently widowed mother on a cruise, but did it have to be on such a meaningful Jewish holiday?
The personal narrative of a woman who was raised Catholic, but had a Jewish father, and her experience taking classes about the Holocaust during college.
A young adult novel describes a 12-year-old child of interfaith marriage coming to terms with the death of her Jewish grandmother.
Article about how a Catholic woman's decision to convert to Judaism opened up her father, born Jewish, to talking about his Jewish past for the first time.
A personal narrative from an unmarried convert to Judaism who was godmother to her committed Catholic sister's child.
The personal narrative of a woman converted to Judaism and her disapproval of the word
The personal narrative of a woman who has recently converted to Judaism and is struggling to create a Jewish environment in her new home.
The personal narrative of a woman of an interfaith family who was raised Catholic but decided to convert to Judaism, like her grandmother had, after being feeling connected at a Bar Mitzvah and years of study of her heritage.
Personal narrative by a Jew-by-choice whose relationship with a Jewish man ended over differences in how observant to be–he called her "too Jewish."
Personal narrative by Jew-by-choice about her boyfriend's break up with her because, even though she planned to convert, in his mind she would never be really Jewish.
The personal narrative of a politically active woman of interfaith families who attributes her activism to the values both parents taught her and links those values to Judaism.
The personal narrative of a woman trying to choose a Hebrew name for her conversion, while honoring both her Jewish and non-Jewish family.
The personal narrative of a woman who ran into difficulties due to inaccurate inferences based on her last name.
Personal narrative by a Jew-by-choice wondering what it is that makes her Jewish.
The story of Ruth is so often used to show that welcoming
After converting to Judaism, the author was surprised to find that she still misses Christmas—a lot.
Personal narrative from a Jew-by-choice coming to terms with giving up Christmas.
Personal narrative?by a Jew-by-choice whose non-Jewish family offered to celebrate Passover with her, but who did not know exactly how to run a seder.
Personal narrative about how a Jew-by-choice found a feeling of family and community among other Jews-by-choice when her Jewish-by-birth boyfriend avoided synagogue life.
Her relatives didn't realize that they had invited her to witness their marriage in church on the Day of Atonement.
Her father had jettisoned his Judaism; she converted to reclaim it. Now he was dead–how would she mourn him?
Personal narrative of a Jew-by-choice describing her questions, thoughts and emotions at the funeral of her beloved Catholic aunt. She feels connected to her family through experience and to her aunt through faith, regardless of religion.
Personal narrative?from a Jew-by-choice who sometimes feels more Catholic than Jewish, especially when the High Holidays remind her of elements of Catholicism that bothered her.


text:
Septarian Gallets 1 LB Lot. This Septarian Gallet was mined from the quarry of Norcross-Madagascar. You will receive your Septarian Gallets, similar to what is photographed, with this order. It's better to buy your Septarian Gallet from Madagascar Minerals, your direct source of Septarian. For more information, please call a Madagascar Minerals® sales representative. (520) 882-8884.
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text:
Please cite this article in press as: Kang et al., iPS Cells Can Support Full-Term Development of Tetraploid Blastocyst-Complemented Embryos, Cell Stem Cell (2009), doi:10.1016/j.stem.2009.07.001
Cell Stem Cell
Brief Report
iPS Cells Can Support Full-Term Development of Tetraploid Blastocyst-Complemented Embryos
Lan Kang, 1 , 2 Jianle Wang, 2 Yu Zhang, 2 Zhaohui Kou, 2 and Shaorong Gao 2 , *
1 Graduate Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China 2 National Institute of Biological Sciences, Beijing 102206, China *Correspondence: firstname.lastname@example.com DOI 10.1016/j.stem.2009.07.001
To our knowledge, for the first time, we demonstrate that induced pluripotent stem cells (iPSCs) can autonomously generate full-term mice via tetraploid blas- tocysts complementation. Differentiated somatic cells can be reprogrammed into iPSCs by forced expression of four tran- scription factors—Oct4, Sox2, Klf4, and c-Myc. However, it has been unclear whether reprogrammed iPSCs are fully pluripotent, resembling normal embryonic stem cells (ESCs), as no iPSC lines have shown the ability to autonomously generate full-term mice after injection into tetraploid blastocysts. Here we provide evidence demonstrating that an iPSC line induced by the four transcription factors can be used to generate full-term mice from complemented tetraploid blastocysts and thus appears to be fully pluripotent. This work serves as a proof of principle that iPSCs can in fact generate full-term embryos by tetraploid complementation. Reprogramming of differentiated so- matic cells into iPSCs via expression of four defined transcription factors has at- tracted great scientific and public atten- tion, and the generation of iPSCs from individual patients has raised hopes for treating many degenerative and genetic diseases ( Dimos et al., 2008; Ebert et al., 2009; Hanna et al., 2007; Park et al., 2008; Soldner et al., 2009; Takahashi et al., 2007; Takahashi and Yamanaka, 2006; Wernig et al., 2008; Yu et al., 2007). iPSCs can functionally differentiate into all cell line- ages within chimeric mice, including germ cells that can ultimately give rise to offspring (Maherali et al., 2007; Okita et al., 2007; Takahashi and Yamanaka, 2006; Wernig et al., 2007). However, unlike ESCs or even somatic cell nuclear transfer (SCNT)-produced NT-ESCs, no iPSC lines have so far fulfilled the most stringent pluripotency criterion of being able to generate full-term mice via tetraploid blastocyst complementation ( Hayashi and
Surani, 2009; Jaenisch, 2008; Maherali and Hochedlinger, 2008; Wernig et al., 2007 ). To understand the reprogramm- ing mechanisms that occur during iPSC generation, it is important to address whether iPSCs are fully pluripotent. As in previous reports ( Brambrink et al., 2008; Stadtfeld et al., 2008 ), doxycycline (Dox)-controlled Tet-on-inducible lentivi- ruses carrying cDNAs of the transcription factors Oct4, Sox2, Klf4, and c-Myc were transduced into mouse embryonic fibro- blast (MEF) cells from ROSA26-M2rtTA transgenic mice ( Figure 1A). After viral transduction, the MEFs were cultured in ES culture medium containing Dox for 12 days until ES-like colonies appeared, and then the Dox was removed from the culture medium ( Figure 1 B). Four days later, ES-like colonies were individually digested and replated in 24-well plates. After propagation, we selected five iPSC lines that exhibited typical ESC morphology ( Figure 1 C) for long-term culture and characterization. The ES-like colonies generated were positive for AP activity (see Figure S1 available online). RT-PCR and qPCR analysis demon- strated that the expression of pluripotency marker genes, including Oct4, Sox2, and Nanog, was comparable across all five iPSC lines and normal ESC lines but showed dramatic differences relative to MEFs ( Figures 1D and 1E). Silencing of the exogenous lentiviral vectors was also observed ( Figure S2 ). Immunofluorescent staining further confirmed the protein expression of three transcription factors and the surface marker SSEA-1 in the iPSCs ( Figure 1F). In addition, other pluri- potency-related genes were all expressed at similar levels in the iPSCs and normal ESCs ( Figure S3 ). The karyotypes of all five iPSC lines were normal, with 40 chro- mosomes ( Figure S4 ). Southern blot anal- ysis was used to examine viral integration into the genome of iPSCs and indicated
that there were one or two integrations for each of the four lentiviral constructs into the iPS genome ( Figure 1 G). To investigate the pluripotency of the generated iPSCs, we performed in vitro differentiation and teratoma and chimera experiments. The iPSCs formed EBs effi- ciently in vitro, and upregulation of marker genes for all three germ layers was de- tected in the plated EBs ( Figure S5 ). We then transplanted the iPSCs subcutane- ously into immune-deficient SCID mice and found that all the iPSC lines tested generated teratomas 3–4 weeks after transplantation. Hematoxylin and eosin (H&E) staining indicated that the iPSCs could differentiate into a variety of cell types from all three germ layers ( Fig- ure 1H). The LiPS-6 line generated post- natal chimeras with normal appearance that gave rise to germline offspring after mating with ICR female mice ( Figure 1 I). However, we could not produce full-term mice from this line via tetraploid comple- mentation. Meanwhile, we noticed a very high degree of chimerism in the chimeras generated from one iPSC line, LiPS-8, as indicated by its chimera coat color, which was almost completely contributed by iPSC ( Figure 1J). We therefore decided to test whether these iPSCs were capable of generating full-term mice through tetra- ploid complementation. We first generated tetraploid embryos by fusing late two-cell-stage embryos to one-cell-stage embryos using an Electro Cell Manipulator (BTX 2001). The embryos were collected from B6D2F1 female mice mated with male mice of the same strain. Ten to fifteen iPSCs were microinjected into the cavity of tetraploid blastocysts, and the complemented blastocysts (n = 200) were transferred into seven pseudo- pregnant ICR female mice after 2–3 hr of recovery. On the due date, a C-section was performed to ascertain whether any of the tetraploid-complemented embryos
Please cite this article in press as: Kang et al., iPS Cells Can Support Full-Term Development of Tetraploid Blastocyst-Complemented Embryos, Cell Stem Cell (2009), doi:10.1016/j.stem.2009.07.001
Cell Stem Cell
Brief Report
Figure 1. Generation of Inducible iPSCs and Characterization
(A) Morphology of MEF cells collected from
ROSA26-M2rtTA transgenic mice.
(B) Colonies formed after infection and Dox
(C) Morphology of iPSCs after propagation.
(D) RT-PCR revealed that inducible iPSCs expressed ESC marker genes including OCT4 ,
SOX2 , and NANOG .
(E) qPCR revealed that the expression level of ESC
marker genes in iPSCs was similar to that of normal
(F) Immunofluorescent staining results demon-
strated that the iPSCs were positive for OCT4, SOX2, NANOG, and SSEA-1. Scale bars, 20 mm.
(G) Southern blot analysis showed that there were
one or two integrations for each virus into the iPS genome.
(H) Teratomas formed 4 weeks after injection of
iPSCs into SCID mice. Tissues of the three germ layers were detected by H&E staining. (I) The chimeric mouse showed germline transmis-
sion capability.
(J) High chimerism (>90%) was found in the
chimeric mice produced from a particular iPSC line (LiPS-8).
had developed into live animals. As shown in Figure 2 A, we produced two full-term mice from the iPSC-complemented tetra- ploid blastocysts. One pup ( Figure 2Ab) was overweight (2.72 g) and died within 1 hr following the C-section. The other pup ( Figure 2 Aa) was of normal weight (1.36 g) and survived for 3 days but died because the surrogate mother refused to feed it. To test whether the fully iPSC- derived mouse can survive to adulthood, we repeated this experiment with tetra- ploid blastocysts from ICR mice. After transplantation of 187 tetraploid-comple- mented blastocysts into the oviducts of seven pseudopregnant mice, we success- fully produced two more full-term pups from these embryos ( Figure 2 A), and one pup survived into adulthood and appears to be healthy ( Figure 2B). The efficiency of generating full-term mice from iPSC- complemented ICR tetraploid embryos was similar to the B6D2F2 background embryos (1.07% versus 1.00%, Figure 2 F). We then performed SSLP and rtTA anal- ysis of the organs collected from the three dead pups and the tail tip of the live mouse. The results clearly indicated that all the pups were derived from the iPSCs (mostly C57BL/6 background) and not from the tetraploid embryos (B6D2F2 or ICR background) (Figures 2 C–2E). More- over, we successfully cultured skin fibro- blast cells from the pups that died shortly after the C-section. After adding Dox to
Please cite this article in press as: Kang et al., iPS Cells Can Support Full-Term Development of Tetraploid Blastocyst-Complemented Embryos, Cell Stem Cell (2009), doi:10.1016/j.stem.2009.07.001
Cell Stem Cell
Brief Report
Figure 2. Generation of iPS-Tetraploid Mice
(A) Four pups were produced autonomously from iPSCs complemented with tetraploid blastocysts
collected from either B6D2F1 mice or ICR mice. One pup from iPS-B6D2F1 tetraploid complementation died 3 days after C-section because the surrogate mother refused feeding (Aa), one overweight pup from iPS-B6D2F1 tetraploid complementation died (Ab), one pup from iPS-ICR tetraploid complementation died shortly after C-section (Ac), and one pup from iPS-ICR tetraploid complementation survived (Ad).
The pup (Ad) generated from iPS-ICR tetraploid complementation grows into an adult.
SSLP analysis of organs of three dead tetraploid-complemented pups (Aa–Ac). D6Mit15 and
D11Mit236 were used.
(D) Genomic PCR analyzed the transgene, rtTA, in the organs of three dead tetraploid-complemented
(E) Genomic PCR and SSLP were performed to analyze the live adult mouse derived from iPS-tetraploid
complementation. Transgene rtTA and D11Mit236 were analyzed, respectively.
(F) Efficiency of generation of iPSC-tetraploid-complemented pups. The efficiency is lower than the
efficiency of using normal B6D2F1 ESCs ( Table S1).
(G) Scatter plots comparing global gene expression patterns between iPSCs and ESCs (left), between
iPSCs and MEFs (middle), and between R1 and MEFs (right), as determined by DNA microarray. ''R'' indi- cates Pearson correlation coefficient, and the lines indicate 2-fold changes in gene expression levels
between the samples.
the medium, many ES-like colonies ap- peared ( Figure S6 ), and the efficiency was substantially higher than for the first round of iPS induction. As the inducible iPSC line LiPS-8 is, to our knowledge, the first iPSC line that has been used successfully to generate mice by tetra- ploid complementation, we investigated the gene expression profile of this partic- ular cell line as compared with the normal ESC lines, R1, and the parental MEF cells. The data clearly showed that the gene expression profile of this specific iPS line is very similar to the normal ESCs ( Fig- ure 2 G). Meanwhile, bisulfite genomic DNA sequencing analysis of the Oct4 promoter showed that it is highly unme- thylated in the inducible iPSC line LiPS-8, whereas it is highly methylated in the parental MEF cells ( Figure S7 ). In conclusion, we have successfully produced full-term mice from iPSC- complemented tetraploid blastocysts. Although these findings are an important proof of principle, it would be premature to make claims based on them about whether iPSCs in general are functionally equivalent to normal ESCs, as we have here only identified one iPSC line that possesses this capacity, and the process is also very inefficient. It is possible that this line has specific characteristics that allow tetraploid-complementation activity but are not shared by other iPSC lines. It will be interesting to evaluate whether iPSCs generated using fewer factors or different approaches are capable of pro- ducing tetraploid-complemented mice ( Kim et al., 2008, 2009; Nakagawa et al., 2008 ) to assist with advancing overall understanding of the molecular mecha- nisms involved in iPSC generation. More- over, partial reprogramming could poten- tially provide an explanation for the inefficient differentiation of iPSCs into certain cell lineages, and obtaining more fully reprogrammed iPSCs in humans might facilitate directed differentiation of iPSCs into ideal cell types.
Microarray data can be assessed at Gene Expres- sion Omnibus (http://www.ncbi.nlm.nih.gov/geo/ ) under accession number GSE17004.
Supplemental Data include Supplemental Experi- mental Procedures, Supplemental References,
Please cite this article in press as: Kang et al., iPS Cells Can Support Full-Term Development of Tetraploid Blastocyst-Complemented Embryos, Cell Stem Cell (2009), doi:10.1016/j.stem.2009.07.001
seven figures, and one table and can be found with this article online at http://www.cell.com/cell- stem-cell/supplemental/S1934-5909(09)00335-X .
We thank Professor Rudolf Jaenisch from the Whitehead Institute of the Massachusetts Institute of Technology for generously supplying the vectors for lentiviruses containing the cDNAs of four tran- scription factors, and Dr. Konrad Hochedlinger for personal communications. We are also grateful to the other colleagues in our laboratory for useful help during experiments and preparation of the manuscript. This project was supported by the Ministry of Science and Technology (grants 2008AA022311, 2006AA02A101, and 2009CB941100) and the National Science Founda- tion of China (grant 30670302).
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Choosing a Construction Company
An experienced and skilled concrete stamping Falls Church VA can provide you with a wide assortment of services to help with basically any construction or repair project you want to begin. If you would like to start the process of building a residential or commercial building, a construction company can ensure that the complete process is done quickly, professionally, and in agreement with regulations. For extensive damage to part of your property, we can undertake the repairs in a safe and effective manner. Our staff can also assist you with updating a tired or outdated kitchen or basement through a complete remodeling project. No matter what the project is, your construction company will take the time to ensure that everything is done perfectly. You want your property to look great and last forever, so why not trust your construction projects to someone who will get the job done right?


text:
- Extends to 15.5 foot
- Collapses to 36.5 inches
- Over-molded feet for safety
- Compact in size
- Light-weighted
- Manual lock system
- Can handle 300 lbs
- Independent locking at every step
- Strong aluminum body
- Extends to 15.5 foot
- Collapses to 36.5 inches
- Over-molded feet for safety
- Compact in size
- Light-weighted
- Manual lock system
- Can handle 300 lbs
- Independent locking at every step
- Strong aluminum body
Whenever we talk about the telescopic ladder, it simply means that the ladder is able to slide outwards and inwards swiftly. It usually overlaps sections. The design of the telescoping ladders is pure genius. Just like the telescope, each level of the ladder slides down to stack on the next level, the lower rung – basically collapsing on its self to save space in the house and maneuver easily. This allows the customer to decide how tall the ladder needs to be in order to complete the work efficiently. Almost any type of ladder can be called a telescopic ladder or collapsible ladder, for example, step ladders, folding ladders, extension ladders, and multipurpose ladders.
Benefits of an Extendable Ladder
Ladders are an essential part of any household. Whether it be for purposes like getting into the loft, cleaning the gutter or cleaning windows, to more commercial utilization such as setting tv aerial setting, security alarm fittings or reaching the rooftop for cleaning purposes. For it is so essential, we know that choosing the correct ladder is extremely important for you. So, here we are going to recommend some of the best telescopic ladders available in the market.
Purchasing the right kind of ladder can ensure that the one purchase will help you complete multiple works, unlike the traditional ladders. The telescoping extension ladder has various benefits over traditional ladders. Its main attraction is its extendable height factor that allows you to reach your rooftop. Although such heights are reachable, with the telescopic ladder you can extend your ladder to its maximum anytime and anywhere. You can choose at what height it is comfortable for you. At the same time, you can change the height of the ladder according to the work. You don't have to carry those traditional, bulky ladders with you. One extendable ladder can help you finish your work within no time.
In addition to that, extendable ladders can easily be carried outdoor and indoor because of its lightweight and aluminum body that is strong and durable for any use. It can reach an optimum height without getting distorted or you getting hurt. Hence, high-quality metal construction makes it ideal for household and professional work.
If these factors aren't enough to impress you, you can consider it depending on its flexibility and portability. This type of ladder is very easy to maneuver from one place to another. Besides, its lightweight and compact size allow you to carry the ladder anywhere and anytime without any tension. It can easily fit in your car trunk as well as kept in the storage room. A telescopic ladder, unlike the traditional ladders, does not need a space of its own. You can fit it in anywhere in the house.
Extendable ladders include rungs that provide a comfortable fit and are offset for extraordinary security. In addition to that, every rung has a manual lock, which ensures extra security while climbing the ladder.
If you are planning to purchase a ladder for your home or professional use, consider going through its benefits. Also, we have created a list of perfect telescopic ladders for home and professional use. Now, without further ado, let's walk through the list.
Best Available Collapsible Ladders review
WolfWise EN131 Telescoping Ladder
Aluminum Extension Tall Multi-Purpose
Best of features
- Material: Aluminum
- Max weight capacity: 330 pounds
- Laser beam color: Silver
- Size: 12.5 ft
- Weight: 25.6 pounds
The Wolfwise Telescopic ladder features a total of 12 steps, with a separate locking system. The separate locking system allows the user to adjust the height according to their specific requirements, such as hanging picture frames in the house, repairing ceiling lights, and painting walls of your office.
Its compact size and lightweight can easily fool anyone. However, it is specifically designed in a way that it can be easily carried anywhere and anytime without having to carry a heavyweight ladder along. Although it weighs only 25.6 pounds, it can easily handle 330 pounds. The ladder can extend up to 12.5 feet to clean the rooftops or fix the tv aerials fitting. The compact size allows the user to save space by fitting this small yet huge ladder anywhere in the house. Users can carry the ladder in the trunk of a car or give it to a child to handle. It fits all your needs. The best feature of this ladder is its high-quality aluminum body that proves to be durable for years to go.
- Is compact in size
- Light-weighted
- Has a manual lock system
- High-quality aluminum body
- Great customer care service
- The aluminum tends to tear off due to weather change.
- Smart-Close system: Due to the upgrading of the internal structure, each step falls slowly and smoothly when retracting, the problem of pinching hand is completely solved.
- One-Button Retraction: It takes only 5-8 seconds to retract the ladder from its full extension, convenient and safe.
- Selected Material: Made of aerospace engineered 6061 aluminum alloy with a Clean-Touch anodized finish, making the ladder have 330 lbs of weight capacity.
- EASY PORTABILITY: At its full length of 12.5 feet, retracts to a quarter of its height for easy storage in your car or other limited space.
- CONSIDERATE DESIGN: Secure the ladder closed with the heavy-duty strap for convenient storage and transport.
Xtend & Climb 780P Aluminum Telescoping
Ladder Type IA Professional Series
Best of features
- Weight: 30.8 pounds
- Size: 12.5 feet
- Colour: Green
- Material: Aluminum
- Warranty: 6 months limited warranty
Xtend Climb ladder is designed for both do-it-yourself and commercial contractors. They are a sensible alternative to traditional bulky ladders. These professional, light-weight and time-saving ladders extend by foot and feature ergonomic designs. They definitely have smooth locking tabs and safe operation.
The styling and strength of Xtend & Climb professional extendable ladders make it the right choice for home and commercial use. They are easily adjustable to whatever size you want. It opens foot by foot that locks automatically. It comes handy when you want a hassle-free job done within minutes. You can simply extend to your comfort. Besides, it is comfortable because with this telescopic ladder you don't need to carry a heavy extended ladder with you.
Considering the safety-view point in mind, this ladder is designed with features like a no-pinch closure system. Besides, there are red and green tab indicators that let you know whether the rungs are locked in place to safely climb the ladder. In addition, they come with no-slip caps to ensure safety and firm gripping on the floor.
- It is light-weighted
- Build with strong material
- Additional non-slip caps
- Tags for extra security
- Covers 6 months limited warranty on repair and parts
- Heavier than other telescopic ladders
- Expensive
- This are multitool accessory
- This are highly durable
- This is manufactured in China
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Telescoping Ladder 12.5 FT Extension Telescopic Ladders
With Spring Load Locking Mechanism
Best of features
- Weight: 24.2 pounds
- Size: 12.5 ft
- Material: Aluminum
- Warranty: Limited warranty on parts
Certified by the European safety standards, the OxGord Telescopic ladder ensures the safety of its users and confirms its durability. This ladder opens up to 12 ft. and can handle a maximum of 330 pounds of weight in a go. It is also equipped with an automatic locking system that self-locks the rungs as soon as you are done. It can be easily used at 75 degrees without any issue.
The OxGord telescopic ladder is perfect for commercial and do-it-yourself purposes. It covers cargo, homes, office, tall building and reaching to the rooftop for cleaning. The ladder comes with additional features, such as 12ft standard extension, carry bag, user manual and 1-year limited warranty for repair of parts.
- Build on European safety standards
- No-slip caps
- Automatic looking system on each foot
- Easy to extend and collapse
- Can handle up to 330 pounds
- 1-year warranty for parts and repair
- Locking sometimes can be a problem
- The body soon tears off due to weather change
- RETRACTS WITH ONE BUTTON: Introducing the most user-friendly ladder you'll ever own! We developed our portable extending ladder specifically with your convenience and safety in mind. With the push of a button, our extension ladder will safely retract making it both easy to use and easy to store.
- NO MORE PINCHED FINGERS! Incredibly safe to use, our ladder utilizes a hydraulic system to form air pockets in the posts in order slow down each step as they collapse. This means that the ladder will slowly and smoothly retract without anything getting stuck between the rungs.
- SUPERIOR STABILITY: Our adjustable collapsible ladder is engineered with high-quality durable aluminum alloy, non-slip traction feet, and extra-wide steps for the safest and most stable climbing experience possible! Just be sure you raise the steps up from the base to lock them into place.
- SAFE & VERSATILE: EN131, CE, and SGS European safety standard-compliant; Our ladders extend from 3.3 feet to 12.5 ft and hold a weight capacity of up to 330 pounds! This makes them great for changing light bulbs, painting, cleaning windows, accessing your attic or roof, and so much more!
- MONEY BACK GUARANTEE: One (1) year limited warranty with a 100% Satisfaction Guarantee! If you're not satisfied, we're not satisfied; That's why we'll happily send you a replacement or your money back.
CORE DISTRIBUTION 770P Telescoping Ladders
Xtend and Climb ladders
Best of features
- Weight: 27 pounds
- Size: 12.1/2 ft
- Material: Aluminum
- Warranty: 6 months limited warranty
Core Distribution telescopic ladder is great for small areas for its compact size and closed height of 32-inch. The ladder is constructed using an airplane grade aluminum alloy that ensures durability. It comes with few safety measures, such as a no-pinch closure system, angled-thumb release mechanism to ensure the correct hand position. Non-slip end caps for strong gripping, cohesive carry handle and strong and heavy-duty closure straps.
It can handle up to 225 pounds of weight at a time. It can extend up to 32-inches (12.1/2 ft.). Besides, to ensure comfortable and satisfying usage, the product comes with a 1-year limited warranty on parts and repairs. Also, customer care services are quite satisfying.
- No-slip caps for strong gripping
- Made of strong aluminum alloy
- Guarantees safety through the self-locking system
- Customer care service is great
- As compared to other ladders, it only extends to 12.1/2 ft.
- Handles only 225 pounds weight
- Ladder retracts compactly
- Extends and locks by the foot with easy, no-pinch closure system
- Integrated carrying handle with heavy-duty closure strap
- Feet have non-slip end caps
- ANSI/OSHA Rated
Ohuhu 12.5 FT Aluminum Telescopic Extension Ladder
One Button Retraction
Best of features
- Weight: 25.4pounds
- Size: 12.5 Ft
- Colour: Silver
- Material: Aluminum
- Warranty: 1-year limited warranty
Crafted from premium quality aluminum alloy, Ohuhu telescopic ladder is designed to carry a maximum of 330 lbs. It is as strong as it's portable – the rungs are strong enough to handle any building type of person. It is the perfect tool to help you clean the rooftops, reach the gutter, change the light bulbs and clean the office windows.
The ladder's high-quality extension mechanism allows you to adjust the height effortlessly and quickly. It extends up to 12.5 ft. The locking pins gives you an assurance of safety and sturdiness. When you are done with the ladder, press the two thumbs and the ladder will retract smoothly. In addition to that, the ladder comes with a bonus carrying strap that remains the ladder compact and closed. You can simply store it in your garage, shed and even in the trunk of your car.
- Available with carrying straps
- One button retraction alloy
- Easy to extend and retract
- 1-year warranty for repairs and parts
- No-slip caps not available on top
- Expensive
- One Button Retraction: Convenience is key! That's why we've designed this ladder with easy one button retraction. Simply press down on the thumb buttons and the ladder will slide down effortlessly.
- Premium Aluminum Alloy: The Ohuhu Telescopic Extension Ladder is crafted from high-quality aluminum alloy. It's lightweight and easy to carry without sacrificing strength.
- Rock-Solid Stability: This ladder is as sturdy as they come, with a weight capacity of up to 330lbs! Non-slip end caps hold the base firmly in place, while extra-wide steps ensure safe climbing. We've also made sure that this ladder is compliant with EN131 and SGS European safety standards to give you some peace of mind.
- Safe to Use: No more pinched fingers! The telescoping ladder's high quality construction ensures that each section expands and retracts safely. Intelligent locking pins hold the sections in place and prevent sliding, and the ladder will retract smoothly and slowly.
- Extreme Versatility: This telescopic ladder is the homeowner's best friend. Thanks to its maximum height of 12.5 ft (3.8m) , the Ohuhu Telescope Extension Ladder is perfect for all of your specific needs. Use it to help paint the walls, change the light bulbs, clean the windows, and everything in between.
Yesker 12.5ft Telescoping Ladder Aluminum
Telescopic Extension Multi-Purpose Ladders
Best of features
- Weight: 26 pounds
- Can handle: 300lbs
- Extends to: 34inches
- Material: Aluminum
- Warranty: 6-months limited warranty
Yesker telescopic ladder is a 12.5 ft., multi-purpose ladder. It is durable enough for everyday use and can handle approximately 300 lbs. Besides, it extends by 2.5 feet up to 12.5 ft. In total, the ladder extends up to 11heights.
The retracted size of the ladder saves time and space in the house. You can smoothly store the ladder in your garage, storeroom or in the trunk of your car. Moreover, the strong aluminum alloy allows the ladder to stay damage-free for a long, long time. It also guarantees safe and smooth usage.
To enhance its safety, the ladder includes no-slip end caps that hold the ladder on the concrete firmly. It also assures that there are no marks left on the walls or on the floor of your house. Besides, the height can be adjusted preferentially as each step has independent locking of one another. Therefore, you can easily change the bulbs in your house or get the walls painted at your office without having to carry those traditional, bulky ladders along.
- Can handle 300 lbs
- Comes with no-slip end caps
- Independent locking at every step
- Strong aluminum body
- Good customer care service
- No warranty available
- One Button Retraction: Convenience is key! That's why we've designed this ladder with easy one button retraction. Simply press down on the thumb buttons and the ladder (completely extended condition) will slide down effortlessly.
- Premium Aluminum Alloy: The Yesker Telescopic Extension Ladder is crafted from high-quality aluminum alloy. It's lightweight and easy to carry without sacrificing strength.
- Rock-Solid Stability: This ladder is as sturdy as they come, with a weight capacity of up to 330lbs! Non-slip end caps hold the base firmly in place, while extra-wide steps ensure safe climbing. We've also made sure that this ladder is compliant with EN131 and SGS European safety standards to give you some peace of mind.
- Safe to Use: No more pinched fingers! The telescoping ladder's high quality construction ensures that each section expands and retracts safely. Intelligent locking pins hold the sections in place and prevent sliding, and the ladder will retract smoothly and slowly.
- Extreme Versatility: This telescopic ladder is the homeowner's best friend. Thanks to its maximum height of 12.5 ft (3.8m) , the Ohuhu Telescope Extension Ladder is perfect for all of your specific needs. Use it to help paint the walls, change the light bulbs, clean the windows, and everything in between.
Buying Guide
For informed buying decision
When you are buying a telescopic ladder, you need to consider a few important features. Some features are immediately visible, like cost, whereas other features are subtle and not on the face due to the lack of knowledge of the product.
In this buying guide, we have mentioned a few oblivious and non-oblivious features of a collapsible type of ladder. It is necessary to make an informed buying decision before purchasing this product.
|Ohuhu 12.5 FT Aluminum Telescopic Extension Ladder, ONE-BUTTON RETRACTION New Design Telescoping...
|1,216 User Reviews
|Check Price on Amazon
|Luisladders Aluminum Telescoping Telescopic Extension Ladder 330 Pound Capacity (12.5 Feet)
|368 User Reviews
|Check Price on Amazon
|Handvoll Telescoping Ladder 15.5ft Aluminum Extension Folding Ladder, Portable Heavy Duty...
|77 User Reviews
|Check Price on Amazon
|Telescoping Ladder Extension Multi-Purpose 18.5 FT Aluminum Foldable Industrial Compact Loft Ladder...
|55 User Reviews
|Check Price on Amazon
|Lionladder 12.5FT EN131-6 Telescoping Ladder, One-Button Retraction, Pro Aluminum Ladder, 330 Lbs...
|63 User Reviews
|Check Price on Amazon
Safety Requirements
The safest collapsible ladder is the one with the highest safety rating for its maximum weight carrying capacity. Make sure you choose a telescopic ladder that has a rating for safety requirements. If it does not meet the safety requirements then please avoid buying it. There are a maximum of three different safety rating pattern for this kind of ladders:-
OSHA: Occupational Safety and Health Organization
ANSI: American National Standard Institute
EN 131: European Safety System
If you come across a ladder that does not show you there safety rating provided by one of these institutions, please avoid purchasing them.
Weight Capacity
One of the things that you definitely want to see is how much weight that ladder can carry safely. When browsing for a good telescopic ladder, you will come across the rating given by the company and the users on the side. The weight matter a lot, therefore, if weight carrying capacity is given a good rating by the users, you can be sure of buying it. Otherwise, please strike it through your list.
Extendable and Retractable
When searching for a ladder that goes to the maximum height, you will come across 16ft as the highest height, a ladder can extend to. Anything above that requires being wider and the body should also be of stronger material.
Telescopic ladder's basic selling point is its lightweight and comfortable portability. However, by making the ladder heavy and wider than its original size can defeat the idea of these ladders.
Comfortable to Use
It is important to look for a ladder that is user-friendly. What can be worst than buying a telescopic ladder that doesn't give you the advantage of its features? Ideally, a ladder should be anti-finger jamming and multi-height adjustment features, just like a type of creepers used by the worker in car service centers.
The anti-finger jamming features prevent from hurting your fingers while collapsing the ladder after its use. It is very common for a retractable ladder to collapse at a very high speed, which can hurt your fingers. You cannot always be alert, therefore, search for something that saves your time and your fingers.
Lastly, the multi-adjustment ladder allows you to extend the ladder at different height according to your needs. This will help you save time.
Don't Risk Your Life
Generally, manufacturers reduce the quality of the aluminum body of the ladder to cut on the total cost. People run after such products that result in either risking their life or purchasing a non-durable product. Low cost is not a sign of good quality, but a way of playing with your life, please be aware of such kind of collapsible ladders.
Finally, we have come to the end of the article. Till here, we have discussed the meaning of this kind of ladders and their benefits. We have also discussed a few best telescopic ladders of 2019. Besides, we have also provided a buying guide for an informed buying decision. So, let's consider these points before actually buying a retractable and collapsible ladder.


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Category Archives: Hikes
Hiking the Trail Between the Lakes
by Ron Bamberg I recently completed a backpacking trip on The Trail Between the Lakes, a 28-mile track that connects Lakes Sam Rayburn and Toledo Bend in deep east Texas. Toledo Bend straddles the Texas-Louisiana line and is formed on the Sabine River. Sam Rayburn, to the west, is formed by the Angelina River. The trail lies entirely within the Sabine National Forest. A sign at the Sam Rayburn trailhead, where I ended the hike, identifies three distinct ecosystems through which the trail passes: Pine… Read More →
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Small business trading slips finds ACCI
Small busing trading conditions have continued to deteriorate in September quarter, with key indexes entering deep contractionary territory, according to the latest Small Business Survey published by the Australian Chamber of Commerce and Industry (ACCI).
The ACCI expects trading conditions to continue to worsen further over the coming months amid rising input costs, subdued consumer demand and looming global economic uncertainties.
The key findings of the report are:
- The small business sector has become increasingly pessimistic about the strength of the Australian economy over the coming year, with the index of Expected Economic Performance edging lower from 40.6 to 38.8 during the September quarter, to be 2.3 points lower through the year;
- Profit Growth slid deeper into contractionary territory, while Selling Prices declined to its new historical low of 44.7, 1.3 points below the low reading of 46.0 previously recorded in June 2009. Small businesses expect profits and selling prices to continue to fall in the December quarter;
- Wage Growth and Non-Wage Labour Costs rose further in September, defying the declining trend reported in a broad range of indicators elsewhere in the Survey; and
- Business taxes and government charges continued to constitute the top barrier to investment for small businesses for the seventh successive quarter in the quarter.
ACCI's Chief Economist, Greg Evans said that the survey shows that conditions remain challenging for small businesses, with revenue, profit growth and investment all approaching historic lows.
"Small businesses have become increasingly concerned that labour costs have continued to rise and remain elevated, despite all other trading indicators trending lower in recent months. Lack of pricing power as manifested by the historical low Selling Prices has dented small business profits and its ability to employ and investment," Mr Evans said.
The Survey assessed business conditions and business confidence amongst 1,643 small businesses around the country over the July, August and September period.


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Israel's Foreign Ministry is calling out pretty much everyone and anyone who has wronged Jews over the last 3,000 years in a history lesson in a satirical video
See video here: www.washingtonpost.com/news/worldviews/wp/2016/10/07/israeli-government-releases-comic-video-dissing-assyrians-greeks-crusaders-arabs/
This satirical video is billed by Israeli diplomats as "a short history of the Jewish people." Cartoons and videos like this are part of a new strategy by Israel to conduct its public diplomacy via social media. (Israel Ministry of Foreign Affairs). This one outlines the "history of the Jewish people" by focusing on Jacob and Rachel, a nice Jewish couple that are pushed out of their home by an endless stream of unwelcome visitors.
Entitled €Welcome to the Home of the Jewish People.€ It stars the characters Jacob and Rachel, a nice Jewish couple, living in a modern suburban-style house called the €œLand of Israel€ ...
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"The plant-based alternative to fish oils and krill oil"
No other plant-based oil comes close to the nutritional profile of ahiflower oil. Not only is it an excellent source of omega-3 fatty acids, it also provides a uniquely balanced combination of omega-6 and -9 fatty acids. Derived entirely from plants, Health Ranger Select Ahiflower Oil and Chief Originals Ahiflower Oil Softgels are the perfect plant-based alternatives to fish oils and krill oils.
Both Health Ranger Select Ahiflower Oil and Chief Originals Ahiflower Oil Softgels contain a well-balanced combination of omega-3, omega-6 and omega-9 fatty acids that supports healthy immunity, vitality and overall wellness. It's made from ahiflowers that are ethically grown by farmers in the U.K. who follow the strict Crop Assured 365® supply-chain requirements to ensure outstanding crop quality and potency. Health Ranger Select Ahiflower Oil can be taken directly or mixed into smoothies, salad dressings, sauces, and other recipes. It tastes slightly nutty, with zero "fishy" taste or smell since it isn't made from fish or krill.
Our ahiflower oil and softgels are gently processed in the USA using patented extraction methods to retain maximum nutrition, and are extensively lab tested for glyphosate, heavy metals, and microbiology. They are also vegan, non-GMO, and lab verified for cleanliness and purity.
Ahiflower oil is derived from the seeds of the Buglossoides arvensis plant. Once considered a weed, this herb is now grown sustainably as an agricultural crop and is valued for its remarkable oil and nutritional content. In fact, ahiflower oil is the richest non-fish source of omega fatty acids on the planet.
Other plant-based oils, such as flax, chia, and hemp seed oils, only contain alpha-linolenic acid (ALA). Only around 3-6% of the ALA you consume is converted into docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). In comparison, ahiflower oil contains stearidonic acid (SDA), which is more readily and more efficiently converted into DHA and EPA. Up to 30% of the SDA you consume can be converted into DHA and EPA. These are fatty acids that support a healthy brain and immune, nervous, and cardiovascular systems.
and what makes it so special?
Omega-3, omega-6, and omega-9 are dietary fats that provide numerous health benefits. Since your body can't produce most of these healthy fats on its own, you need to consume a balanced ratio of omega-3, omega-6, and omega-9 fatty acids to maintain optimal overall health.
Omega-3 fatty acids are essential polyunsaturated fats. An essential nutrient is one that your body cannot produce by itself and must be obtained through your diet. Omega-3s offer a diverse range of benefits, including supporting healthy nervous, immune, cognitive, and cardiovascular functions, as well as supporting healthy vision and bones. ALA, DHA, EPA, and SDA are four important forms of omega-3. Your body can convert a small percentage of ALA into DHA and EPA, and it can convert SDA into these same forms of omega-3s with much greater efficiency.
Just like omega-3s, omega-6 fatty acids are essential polyunsaturated fats that you need to get from your food. Although close to omega-3s in terms of structure, omega-6s provide a different set of benefits. They are essential for supporting healthy development, healthy heart function, energy, and immunity. A balance between omega-3s and omega-6s is crucial for overall health. Gamma-linolenic acid (GLA) and linolenic acid (LA) are two types of omega-6 fatty acids that can be found in ahiflower oil.
Unlike other omega fatty acids, omega-9 fatty acids are monounsaturated fats. They are technically not essential because they can be produced by the body, but studies show that boosting your omega-9 levels through diet can offer plenty of health benefits. These good fats support healthy immune, cardiovascular, nervous, and reproductive systems. Omega-9 fatty acids can also support healthy energy levels and help you feel more satiated after a meal. Ahiflower oil contains the omega-9 fatty acid, oleic acid (OA).
Fatty fish are loaded with essential fatty acids, including omega-3s and omega-6s. However, if you're following a vegetarian or vegan lifestyle, it may be hard to get these fatty acids from your diet. While there are other plant-sourced oils, few contain omega-6 GLA or omega-3 SDA. Flaxseed oil rose to popularity as a plant-based alternative to fish oil, but it does not contain GLA. A study also revealed that EPA conversion is 4x more efficient with ahiflower oil than with flaxseed oil.
The most efficient vegan source
of essential fatty acids
Fortunately, ahiflower oil provides an efficient way to incorporate these essential fatty acids into any diet. In fact, it produces the only plant-based, non-GMO dietary oil with a higher metabolic conversion to EPA than other popular plants, such as flax, chia, hemp, perilla, sancha inchi, and echium. It is also remarkable in providing a uniquely balanced daily combination of essential omega fatty acids.
The best part about ahiflower oil is that it has no fishy taste or smell and carries none of the side effects associated with other non-vegan omega supplements. Plus, it has none of the mercury contamination risk often found in fish oils.
Ahiflower is packed with omega-3 fatty acids known to support healthy bones.
Supports healthy bones
Ahiflower oil is packed with heart-healthy omega-3s. The SDA in ahiflower oil is efficiently metabolized by your body, which leads to heightened levels of EPA in the body. High levels of EPA, combined with a balanced diet and healthy lifestyle, are known to support great cardiovascular health.
Maintains a healthy cardiovascular system
Poor intake of DHA may lead to eye problems. Supplementing with ahiflower oil can easily boost your intake of DHA and support healthy, normal vision.
Supports healthy vision
Omega-3 fatty acids are important for a healthy immune system.
Supports a healthy immune system
Regularly consuming healthy doses of DHA and other omega fatty acids can help support the overall health of your body, especially in relation to the functions of your brain and nervous system.
Supports healthy brain function
Omega-6 GLA, one of the prime nutrients found in ahiflower, is notably helpful in maintaining peak joint health. Ahifllower oil also contains high levels of SDA that can help support healthy joints.
Supports healthy joints and mobility
Regular consumption of healthy fats such as those found in ahiflower oil may help uplift your mood.
Uplifts and elevates mood
The abundance of dietary fats in ahiflower oil allow it to offer a number of important health benefits:
Each half-teaspoon serving of Health Ranger Select Ahiflower oil delivers:
An imbalance in your intake of healthy fats can lead to impaired health outcomes. Fortunately, Health Ranger Select Ahiflower Oil and Chief Originals Ahiflower Oil Softgels both contain a well-balanced combination of omega-3, -6, and -9 fatty acids. There's no need to purchase three different supplements or worry that you are not getting the optimal amount of omega fatty acids necessary for sustained wellness.
provides a perfectly balanced
ratio of omega fatty acids
A single 3-softgel serving of Chief Originals Ahiflower Oil Softgels can provide:
Ahiflower oil is an ideal companion to your daily workout. The presence of omega-6 GLA in ahiflower oil is especially essential to physically active individuals because it supports healthy joints and mobility.
Additionally, the high content of omega-3 fatty acids in ahiflower oil can help fuel your workout by supporting healthy energy levels. When accompanied by a healthy diet and regular exercise, the balanced presence of omega-3, -6 and -9 fatty acids in Health Ranger Select Ahiflower Oil and Chief Originals Ahiflower Oil Softgels can help you get the most out of your workout and support your overall health and well-being.
Mercury contamination – Mercury is a toxic heavy metal that can damage your organs and neurological system. The world's oceans and other bodies of water contain traces of this toxin, which then accumulate inside the bodies of fish in a process called biomagnification. Because of this, many omega-3 supplements derived from fish may be contaminated with levels of mercury that may be toxic to consume. Ahiflower oil contains none of the mercury contamination risk found with fish oils.
Improper preservation – Many fish oil-based supplements are prone to breaking down more quickly than plant-based omega supplements, especially when they are not properly preserved. Our premium ahiflower oil and oil softgels are gently processed in the USA with patented extraction methods to retain maximum nutrition and freshness.
Unsustainable and untraceable sources – There are claims that fish-derived omega-3s help preserve marine species, but this is often marketing hype. Studies have found that farming fish for supplements actually depletes both the supply and diversity of fish. The practice also contributes to the spread of invasive species that compete with native fishes for resources. In contrast, one acre of ahiflower produces as much oil as 40,000 mackerel or sardines. Since ahiflower is grown by a select number of U.K. farmers and monitored under the country's strict crop production system, each batch of ahiflower can be traced back to the farm from where it came.
Incomplete ratio of omega fatty acids – Obtaining all the fatty acids your body needs can be difficult, since most supplements on the market offer just one or two types of omegas at a time. Moreover, studies have shown that to get the most benefits out of these good fats, you need to consume all of them together in a properly balanced ratio. With Health Ranger Select Ahiflower Oil and Chief Originals Ahiflower Oil Softgels, you get a well-balanced combination of omega-3, omega-6 and omega-9 fatty acids that supports optimal immunity, vitality and overall wellness.
Unlike other commercially available omega supplements, Health Ranger Select Ahiflower Oil and Chief Originals Ahiflower Oil Softgels come with no drawbacks. Instead, you get high-quality omega supplements that are:
Why choose Health Ranger Select
Specially formulated to contain a balanced, unparalleled combination of omega-3, -6, and -9 fatty acids – Our premium ahiflower oil and oil softgels combine all the omega fatty acids and present them in vegan-friendly, easy-to-absorb forms. You don't need to stress over having to buy three supplements and worrying about how much of each you need – both products have all the omega fatty acids in carefully balanced concentrations that your body can readily put to good use.
Ethically grown in the U.K. and made in the USA – At the Health Ranger Store, we value the environment and we value your health. For this reason, our ahiflower oil and oil softgels are made from ahiflower plants sustainably grown in the United Kingdom. They are then brought to the USA where they are gently processed with patented extraction methods to retain maximum nutritional value.
Easily converted into EPA –
EPA is an omega-3 fatty acid that supports brain, heart, and joint health. Most plant-based supplements contain ALA, only a small fraction of which is converted into EPA. However, ahiflower oil contains SDA, which can be converted more readily and more efficiently into EPA.
Free from any "fishy" aftertaste –Because our ahiflower oil and oil softgels are made entirely from plants, they have none of the fishy aftertaste common in fish-based supplements.
Lab-verified and non-GMO – Health Ranger Select Ahiflower Oil and Chief Originals Ahiflower Oil Softgels are derived from only one plant ingredient – ahiflower. Both products are non-GMO and are lab tested for heavy metals, microbiology, and glyphosate
Ahiflower oil and softgels are packed with an ideal balance of omega-3, -6, and -9 fatty acids – nutrients that support a healthy immune system, joints, cardiovascular function, and brain. With Chief Originals Ahiflower Oil Softgels and Health Ranger Select Ahiflower Oil, you get all the health benefits of omega fatty acids in lab-verified, plant-based supplements. Our premium ahiflower oil and softgels are vegan, non-GMO, Crop Assured 365®, and are thoroughly lab tested for glyphosate, heavy metals, and microbiology.
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No. Average cost strictly applies to mutual funds and dividend reinvestment plans and cannot be used to calculate cost basis for individual securities.
In compliance with Treasury Department Circular 230, unless stated to the contrary, any information contained in this FAQ was not intended or written to be used and cannot be used for the purpose of avoiding tax penalties that may be imposed on any taxpayer.


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A Sports Utility Vehicle (SUV) is often chosen as a family car as it may have the capacity for around 7 people. Another popular choice for a family car is a pickup truck. It provides large rooms for passengers and goods storage area. If you would like a reputable SUV or pickup truck for your family, Mitsubishi Motors Malaysia has what you desire.
Mitsubishi Motors Malaysia Sdn Bhd was established in Malaysia on 29 Jan 2005. From then, that they have brought various of Mitsubishi's vehicles that high quality and fuel efficiency into Malaysia's market. As per their catalog now, they offer 3 types of models named ASX, Outlander, and Triton. Many rewards and recognition have been gained from local spectators.
Mitsubishi ASX mid-sized SUV is really hit among motorists due to its high tools level. It capabilities with the day running lights and rear reclining seats. Don't forget to mention the panoramic glass roof that offers you more organic light in the cabin far better have a look at that stylish skyscraper. Sounds good right? For those who seek for the big family car, Outlander is the choice for you. Outlander has been chosen as the best SUV for the 2016 CarSifu awards. Besides being reasonably priced, this SUV also offers the technology of 4 Wheel Drive (4WD) featuring a smart 4WD system. An individual can come up between 4WD Eco, 4WD Auto, and 4WD Lock.
If you're seeking a pickup truck, you'll be able to try the Mitsubishi Triton. With a MIVEC Turbo-Diesel engine and variable valve timing technology, the Mitsubishi Triton 4WD will give you a risk-free and cozy drive on your own journey. Furthermore, it can help to encourage fuel efficiency which enables you to cut back on your own petrol!
However, if you're tight on budget, you can still opt for the Mitsubishi Triton 2WD. At a lower price tag, you still get to enjoy most of the safety and comfort features perfectly located at the 4WD. Make use of the money saved and bring your loved ones to a family adventure together with the Mitsubishi Triton 2WD. Having its huge cargo space, carry as numerous stuff as you wish! Founded in April 1984, Ralliart develops and get ready Mitsubishi Motors' rally racing and off-road racing vehicles. It also offers many forms of car, boutique products and sporting apparel for car fans. Check out the merchandise now through the Mitsubishi Motors Malaysia's website!
Mitsubishi promises in offering reliable, high-quality and award-winning family cars that will ensure the safety of you and your loved ones on the highway. Take a peek at Mitsubishi Motors Malaysia's website to find out more about the cars and trucks or book a test drive. With Mitsubishi, you can drive your ambition.


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Jean Piché
Jean Piché is a composer and video artist from Montréal, where he lives and teaches at the Université de Montréal. His creative output over the past 20 years has explored the more adventurous edges of high technologies applied to music and moving images, including live electronics, fixed electronic media and performance. He has received numerous international awards and his work has been shown and heard in Europe, Asia and North America. After active collaborations with renowned video artists, he now directs and produces his own video work, focusing on parallel compositional paradigms for abstracted visuals and music, a new groundbreaking hybrid form which has been called "videomusic". His first opera " Yo Soy la Disentegracion " was produced in 1997 by the Montreal company Chants Libres. He was program officer at the Canada Council in the 80s and in 1990, produced the last iteration of the New Music America Festival.
For the past few years, he has been involved in software design to facilitate the specification of control vectors for digital sound synthesis and processing. These activities have led to the creation of the program Cecilia which was awarded First Prize at the International competition for musical software in Bourges. Since 2000 he has developed a synchronised video projection system for three large screens and an image acquisition system with three digital cameras. This system is used for his productions and public performances.
Sept 2004


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