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SHDB can serve as a valuable tool to conduct risk assessments around complex social issues.
It is a tool that supports not only supply chain managers, but has applications for policy-makers, development organizations, investors and donors as well. This information is not produced to provide incentive to divestment in high-risk regions. On the contrary, the data made available should direct attention to social issues that are in need of enhanced engagement.
When you conduct S-ROI analysis, you must capture relevant data in a tool that allows you to analyze potential returns from an environmental, social and financial perspective, for each stakeholder involved. Typically, an S-ROI engagement involves an in-person workshop where multiple affected stakeholders gather physically in a room to assess a project or situation. The 3Pillars software platform, developed by EarthShift, was designed to facilitate S-ROI assessments using advanced uncertainty and probability analysis, and social networking tools.
3Pillars enables a facilitator to enter and analyze data from an S-ROI workshop or to open up a virtual discussion to take the place of the workshop. Alternatives, scenarios, and costs and benefits are easily entered into a simple and intuitive graphic user interface.
Examples of SHDB applications are listed below:
Prioritize site-specific data collection and audits.
Produce product category and commodity sustainability assessment.
Inform Socially Responsible purchasing processes (e.g. questions to be asked when sourcing).
Advise investment opportunities.
Provide perspective and context to site-specific assessment results and sustainability reporting.
Develop sponsored programs designed to improve the social conditions of production.
Communicate about governmental policy and programs.
Assess/report on the scope of a certification or social footprint results.
Educate about the social conditions of production.
In particular, recent applications of the SHDB by our users include:
Project sustainability assessments: a UK university used it for a biorefinery sustainability assessment. A large number of consultants and academics located on 4 continents report using the SHDB portal in their projects.
Supply chain social due diligence: the US Cradle to Cradle Institute certification encourages participating companies to use the SHDB to conduct supply chain social risk reviews.
Trading partners sustainability performance assessment: an EU government agency is using the tool to perform an initial assessment.
Subscriptions and order form
Different price options are available depending on country development and affiliation however only Australian prices are shown below. There is separate pricing for the SHDB and annual service contracts.
Prices - All prices in Australian dollars excluding GST
Database pricing for Australia
Licence types
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Public / Private sector additional $4,914
Multiple academic $7,020
Single academic $4,212
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Public / Private sector additional $2,457
Multiple academic $3,159
Single academic $2,106


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WESTERN SYDNEY AIRPORT | Airport freight agreement announced
Ten of Australia's major freight companies have entered into agreements with WesternSydneyAirport.
Airport chief executive GrahamMillett said: "The unrestricted 24/7 operations will be key to unlocking new export opportunities for businesses and producers," he said. "Goods produced in NSW will no longer have to be trucked to Brisbane or Melbourne to reach lucrative Asian markets overnight."
Freight companies signing up are AustraliaPost (including StarTrack), DBSchenker, DHLExpress, DSVAir&Sea, FedEx, MenziesAviation, Swissport, QantasFreight, SkyroadLogistics and Wymap.
The airport's first stage has potential to process 220,000 tonnes of air freight annually. The freight hub will have dedicated road access off The Northern Road, separating heavy vehicles from passenger traffic, which will enter the airport from the M12 on the site's opposite side.
Liverpool Council also welcomes the NSW Government's agreements with global companies to set up in the airport precinct while the NSW Premier was in Britain and Germany on a trade mission. "We're particularly excited about the news that global defence manufacturer BAESystems has signed a memorandum of understanding to build a new space and research facility," mayor WendyWaller said.
"The AustralianSpaceAgency is based in Adelaide but the real work is being done in the South-West. BAE Systems is going to increase its presence in Australia from 4000 jobs to 7500 jobs in the next five to 10 years."
Discuss "Freight's aboard"
Please note: All comments made or shown here are bound by the Online Discussion Terms & Conditions.

subset: commoncrawl


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Update: St. Paul's Grand Old Day revived
Grand Old Day will take place after all.
The announcement came Thursday afternoon, just over a week since the Grand Avenue Business Association canceled the street festival that has drawn hundreds of thousands to St. Paul's Grand Avenue on the first Sunday in June.
Organizers said their fundraising couldn't cover their costs. Within days, some business owners and others announced a last-ditch effort to rescue Grand Old Day.
On Thursday, the festival's Facebook page announced its revival.
Read or Share this story: https://www.sctimes.com/story/news/local/minnesota/2019/05/03/update-st-pauls-grand-old-day-revived/3661304002/


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It's time to wind down another year of country living. But it's also time to get ready for a new year! When you're not giving gifts and cooking up a storm this Christmas season, how about taking some downtime to think about future projects to tackle on the homestead? We've added plenty of new content…
Tag: Holidays
Merry Christmas 2018
Best wishes for the Christmas season, plus our Best of 2018 lineup.
15 Gifts for the Country Living Enthusiast
Make this year's gifts meaningful with something they can use in their country living adventure.
Free Today (November 14, 2018): The Worst Jokes I Know (and I Know a Lot!)
Did you get a chance to read The Worst Jokes I Know (and I Know a Lot!) for free last week? If not, we'll give you another opportunity! The Worst Jokes I Know (and I Know a Lot!) by B. Patrick Lincoln is a collection of 101 Funny Bone Ticklers for Jokesters of All Ages….
Merry Christmas 2017
It's Christmas time once again! Thank you for another great year at Homestead on the Range! We are looking forward to bringing you even more helpful country living information in 2018. Meanwhile, if you are looking for some helpful resources to start the new year right or just for a little interesting reading, allow us…
Last-Minute Gift Idea: The Worst Jokes I Know
Searching for an inexpensive last-minute gift idea perfect for children? Take a look at The Worst Jokes I Know (and I Know a Lot!): 101 Funny Bone Ticklers for Jokesters of All Ages by B. Patrick Lincoln. This illustrated book is sure to delight jokers (cards, you might say) of all ages with puns new…
Scripture Passages of the Month: December 2017
Isaiah 9:1–7 Matthew 1:1–17 Luke 1:26–38 Luke 2:1–20 John 1:1–18
The Dawning of Indestructible Joy
Christmas…. A time of music and laughter. A time of bright lights and tinsel. A time of friends and family. A time of giving and sharing. But more than that. A time to celebrate the beginning of the greatest miracle the world has ever known. A miracle that took just a little over 40 years…
10 Gifts for Gardeners
Christmas is just around the corner! If you are looking for a few ideas to bring a smile to the face of that gardener in the family this year, allow us to make a few recommendations. The Family Garden Journal. Our garden journal is a great way for a gardener to celebrate a year of…
Merry Christmas 2016
It's already that time of year again—time to celebrate the birth of Christ and enjoy the company of our family members! Cold weather and snow mean that it is also time to find a cozy seat and catch up on some research and reading. Please enjoy this year's lineup of our best content. We're looking…


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Greasestock was an American event held yearly in Yorktown Heights, New York. Exhibitors showcase a variety of alternative energy vehicles, as well as exhibits with a sustainable lifestyle theme.[1] Although it is illegal in New York to power a vehicle with waste vegetable oil, authorities in New York have stated they had no problem with the festival and even participated in it.[2]
The event was founded in 2003 by individuals who shared an interest in vegetable powered vehicles.[3] It is held on the grounds of Peter Pratt's Inn, a historic landmark.[4][5] According to Jon Pratt, founder of the event, while the original event hosted only eight people interested in discussing alternatives to gas, each successive incarnation of the Greasestock celebration has drawn more and more visitors from all over the United States who are interested in cheaper gas, cleaner energy, and helping the environment.[6]
The green technologies demonstrated at the event include vegetable oil powered cars, biodiesel cars, solar powered cars, home heating alternatives, and organic farming exhibits.[7] The event draws exhibitors from all over the United States, and included among the hundred or so vehicles on display is a vegetable powered garbage truck from Mamaroneck, New York, the first of its kind in New York.[8]
- ^ "Greasestock 2008 Archived 2008-05-29 at the Wayback Machine". Greasestock . Retrieved May 20, 2008.
- ^ Tillman, Adriane. "Greasestock Festival returns, bigger and better Archived 2008-06-14 at the Wayback Machine". North County News. May 14, 2008.
- ^ Max, Josh. "Gas-guzzlers become veggie delights at Greasestock in Yorktown Heights". NY Daily News. May 13, 2008.
- ^ Applebome, Peter. "Fill It Up, Please, and Check for Clogged Arteries". New York Times. May 3, 2006.
- ^ Reed, M.H. "Steeped in the Past, Looking to the Future Archived 2008-05-15 at the Wayback Machine". New York Times. September 30, 2007.
- ^ "Fill 'er up with canola". ABC News. May 19, 2008.
- ^ "Greasestock 2008: Alternative Fuel, Fun and French Fries Archived 2008-05-29 at the Wayback Machine". Natural Awakenings. May 2008.
- ^ Golodryga, Bianna and Hoffman, Jessica. "Greasestock Celebrates Alternative Fuel". ABC News. May 19, 2008.
External links[edit]


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Learn more about Scribd Membership
Discover everything Scribd has to offer, including books and audiobooks from major publishers.
Recognized Treatment Techniques For Meeting Drinking Water Regulations For The Reduction Of Fluoride From Drinking Water Supplies Using Point-of-Use/Point-of-Entry Devices And Systems
Recognized treatment techniques for meeting drinking water regulations for the reduction of fluoride using point-of-use and point-of-entry (POU/POE) devices and systems.
Fluorine is a natural trace element and exists in almost all soils. In elemental form fluorine is a flammable, irritating, and toxic halogen gas that is one of the most powerful oxidizing agents known. It therefore occurs naturally only in the reduced (fluoride, Fl - ) form in combination with other minerals. Fluoride is classified as any binary compound of fluorine with another element. Fluoride compounds make up approximately 0.08 percent of the earth's crust. Fluorspar, cryolite, and fluorapatite are the most common fluoride producing compounds known. Fluorspar contains the highest percentage of fluoride by weight, as calcium fluoride (CaF 2 ), of the minerals mentioned.
Perhaps the most widely known use of fluoride is its addition to public drinking water supplies at about one milligram per liter (mg/L) of a fluoride salt, measured as fluoride, for the purpose of reducing tooth decay. This is achieved at the municipal treatment plant by injecting or feeding a solution of hydrofluosilicic acid, sodium silicofluoride, or sodium fluoride into the treated water stream. It is the fluoride ion in mineral ionic form that occurs in water, bones, teeth, and public drinking water supplies. About 144 million people it was estimated in 1992 drink fluoridated water at levels ranging from 0.7 to 1.2 mg/L.
Health Effects
Some water systems with naturally occurring fluoride must treat their water supply to remove the excess fluoride to comply with the Safe Drinking Water Act limits. Children under nine years of age exposed to levels of fluoride greater than about two mg/L may develop a condition known as mottling or discoloration of the permanent teeth. In certain cases the teeth become chalky white in appearance. The U.S. Environmental Protection Agency has advised a secondary maximum contaminant level (SMCL) limit of two mg/L to protect against this aesthetic or cosmetic adversity from fluorides in drinking water. Further, federal regulations require that fluoride not exceed a concentration of four mg/L in drinking water. This is an enforceable maximum contaminant level (MCL) standard; it has been established to protect public health. Exposure to drinking water levels above four mg/L for many years may result in cases of crippling skeletal fluorosis, which is a serious bone disorder resembling osteopetrosis and characterized by extreme density and hardness and abnormal fragility of the bones (sometimes called "marble bones.")
When a community water system exceeds the MCL of four mg/L, it must notify each of its customers by issuing a public notice to those customers. This notice outlines the limitations and health effects from high fluoride levels in drinking water and points out home treatment systems and bottled water as possible drinking water source alternatives.
Treatment Alternates
For large municipal treatment systems, the use of activated alumina is probably the most commonly used fluoride removal technology. Activated alumina requires a two-step, caustic (NaOH) regeneration followed by acid (H 2 SO 4 ) neutralization, regeneration process. This technology is now being used in exchange tanks for POE (point-of-entry) and disposable filters for POU (point-of-use) applications. For activated alumina to operate most effectively the pH range should be held to 5.5 to 6.5. Activated alumina is generally specific for fluoride and is not affected significantly by the common other competing sulfate, nitrate, or chloride anions in the influent water.
POU reverse osmosis is an excellent choice for the reduction of fluoride. Using a cellulose acetate/cellulose triacetate (CA/CTA) membrane, rejection rates of 80-90 percent are achievable when the pH is in the 4-8.5 range. Thin Film Composite membranes (TFC) will yield a higher rejection rate (up to 95 percent) in the 3-11 pH range. Both the CA/CTA and TFC membranes should be operated at a minimum membrane pressure differential of at least 30 psi.
The use of bone charcoal or bone char (carbonized animal bone) is reported to be an effective means for the reduction of fluoride. Bone charcoal contains a carbon structure while supporting a porous hydroxyapatite matrix (a calcium phosphate hydroxide in crystalline form which is rich in surface ions which can be readily replaced by fluoride ion). Adsorption and ion exchange are thought to be the mechanism for fluoride reduction by bone char. Regeneration of this material can be accomplished by a two percent sodium hydroxide rinse and a backwashing cycle. Reduction of fluoride using bone charcoal is somewhat pH dependent, the challenge water should be below 6.5 pH to suppress any ion competition.
Electro dialysis, deionization, and distillation would also be effective treatment processes.
The treatment methods listed herein are generally recognized as techniques that can effectively reduce the listed contaminants sufficiently to meet or exceed the relevant MCL. However, this list does not reflect the fact that point-of-use and point-of-entry (POU/POE) devices and systems currently on the market may differ widely in their effectiveness in treating specific contaminants, and performance may vary from application to application. Therefore, selection of a particular device or system for health contaminant reduction should be made only after careful investigation of it's performance capabilities based on results from competent equipment validation testing for the specific contaminant to be reduced.
MCL, mg/L
Treatment Methods
Fluoride (F-)
Activated Alumina
Reverse Osmosis:
Electro dialysis
Bone Charcoal
Because of the diverse influent water chemistries and product designs, water analysis tests to confirm effective treatment by any of the POE units for fluoride removal is recommended. Only POU units tested and certified for fluoride reduction are recommended to be used for such purposes.
The Water Quality Association publishes this Technical Application Bulletin as a service to its members and the interested public. Information contained herein is based upon the most recent public data known as of the publication date, which is printed at the bottom of the last page, and of course, cannot take into account relevant data published thereafter. The Water Quality Association makes no recommendations for the selection of a treatment system, and expressly disclaims any responsibility for the results of the use of any treatment method or device to reduce or remove a particular contaminant.
CDC. "Water Fluoridation – Surgeon General's Statement on Community Water Fluoridation" http://www.atsdr.cdc.gov/tfacts11.html, Dec.14, 1995.
Code of Federal Regulations, Title 40, part 143, section 5; July 1,1999; p560.
Faust,S.D., and Osman M.Aly, "Chemistry of Water Treatment", Ann Arbor Press., 2 nd Ed., 1998, p417.
WQA wishes to express sincere appreciation for the unselfish contributions of the following members of WQA who contributed their time and expertise toward the completion of this bulletin.
Water Sciences Committee
Frank A. Brigano, Ph.D. Michael Gottlieb Joseph F. Harrison, P.E., CWS-VI Bret L. Petty, CWS-II
Robert B. Ruhstorfer II, CWS-V Glen Trickle, P.E. Stephen J. VerStrat Rod Yoder
Contributors and Reviewers
Jeffrey G. Franks, CWS-V Michael Gottlieb Joseph F. Harrison, P.E., CWS-VI Michael C. Keller Charles F. Michaud, CWS-VI
Albert F. Preuss, Ph.D. P. Regunathan, Ph.D James Sabzali John Schlafer, CWS-VI, CI
Copyright © 2004 by Water Quality Association. All rights reserved. Printed in the United States of America. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electric, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher.
This reference document is published by:
National Headquarters & Laboratory 4151 Naperville Road • Lisle, Illinois 60532 Tel: 630 505 0160 • Fax: 630 505 9637


text:
Plastic pollutants in water environment
Mrowiec Bożena;
- Publisher: Sciendo
- Journal: Environmental Protection and Natural Resources (issn: 2353-8589)
Related identifiers:
- Subject: plastic pollutants | microplastics | water environment | ecological effects | Environmental technology. Sanitary engineering | TD1-1066
Nowadays, wide applications of plastics result in plastic waste being present in the water environment in a wide variety of sizes. Plastic wastes are in water mainly as microplastics (the size range of 1 nm to < 5 mm). Microplastics have been recognized as an emerging t... View more
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- Environmental Protection and Natural Resources via DOAJ-Articles (Article, 2017)


text: Design a beautiful dress with this cute Latina Princess in this beautiful new management game called Latina Princess Magical Tailor. This beautiful Latina Princess wants to design a cute new dress for her lovely daughter. Start by cleaning the room where you will design the dress. The room is a mess from the last time the princess designed a dress for her daughter and all her items that she needs for the design process are all over the place. Help her find all the missing objects and after the room is clean and tidy, you can start the design process. Her daughter is ready for the new dress and you can start working on it. Take the measurements and cut the material. Use pins and glue for the dress, and with a little bit of magic, you are done. The dress look wonderful and the little princess loves it. Have fun playing this cute game and have a great time with the Latina Princess!


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- $55,000 price
- 6000468 listing id
- Status: Active
Enjoy the surrounding mountains and incredible views from this great lot! Build your ultimate mountain dream home nestled on this lush green forested lot. Enjoy views of San Francisco Peaks and other surrounding mountains. Borders state land for easy trail and hiking access. Get it while you can! Tall pines, blue spruce, deep-wood, very peaceful and private location. Check it out before it's gone!
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Listing ID 998797
622 W Lee Boulevard 429 Prescott, AZ
Listing Agent: Chad Nanke
Courtesy of: Better Homes and Gardens Real Estate BloomTree Realty
Courtesy of: Keller Williams Northern AZ
Office Phone: (928) 421-4550
Copyright Arizona Regional Multiple Listing Service, Inc. All rights reserved. Information is deemed reliable but not guaranteed.
Updated: 23rd January, 2020 1:00 AM.
0 Forest Service Rd 261A -- Prescott, AZ


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Alexander: Johnny Isakson Has Contributed an Example of Statesmanship and Service That Will Last for a Long Time
"We will miss his civility, independence, and genuine good will, and I will miss regularly seeing a good friend."AMSCOPE 350X 700x60mm Telescope for Kids Beginners Refractor w Tripod
Alexander: "Working Together, We Will Do Our Best" to Help Prevent Suicides on Natchez Parkway Bridge
Says new call boxes can help someone in crisis find help, planning to design barrier is underwayRead More
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Says students — who, in 1956, were the first to integrate a public high school in the south — served as an example during Civil Rights Movement and still do todayRead More
Alexander: Trump Administration Rule Will Help Rural Tennessee Hospitals
Since 2010, 12 rural hospitals in Tennessee have closed downGood Smile The King of Fighters XIV Shiranui Nendgoldid Action Figure
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Says new call boxes can help someone in crisis find help, planning to design barrier is underway
Alexander: Johnny Isakson Has Contributed an Example of Statesmanship and Service That Will Last for a Long Time
"We will miss his civility, independence, and genuine good will, and I will miss regularly seeing a good friend."
Alexander: Clinton 12 — An All-American Story
Says students — who, in 1956, were the first to integrate a public high school in the south — served as an example during Civil Rights Movement and still do today
Trumpeter 02417 1 24 Hawker Hurricane Mk.IID Tropical hot
Since 2010, 12 rural hospitals in Tennessee have closed down
Alexander to State Legislators: I Need Your Help to Make It Easier for Students to Apply for College
Says state legislators have played a significant role in restoring decisions about education to teachers, parents, school superintendents
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Sen. Alexander at the "missing link" of the Foothills Parkway
"If you want to see the Smokies, you'll drive the Foothills Parkway because it's the only road that gives you such a spectacular view of the highest mountains in the eastern United States. The missing link is so picturesque it is worth the 75-year wait."
Alexander Acosta sworn in as U.S. labor secretary.
"Mr. Acosta can begin working to help create the right environment for more workers to realize the American dream, and I look forward to partnering with him on that important task."
Sen. Alexander visited with Dr. Scott Gottlieb and his family
"Dr. Gottlieb has impressive qualifications helping American patients as both a physician and in his previous roles at the FDA."
Senator Alexander at Tennessee Tuesday
Senator Alexander meets with constituents from Tennessee at Tennessee Tuesday, a weekly constituent breakfast hosted by Sens. Alexander and Corker in Washington.
"It was a pleasure meeting with Judge Gorsuch."
"He is an impressive individual with outstanding academic credentials and an excellent judicial record."
Item specifics
|Used :
An item that has been used previously. See the seller's listing for full details and description of any imperfections.See all condition definitions- opens in a new window or tab
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|"Box has wear, kit intact."
Gunze Sangyo
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Broward Community College Transcript Request You may be able to take a course through Broward Virtual School. Fill out your senior survey and final transcript request form. If you want to check out the group for yourself, it is holding
The Macau University of Science and Technology (MUST) has enrolled some 2,500 undergraduate. Almost 80 per cent of all.
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Learn about the MBA programs at NTUST and other business schools in Taiwan. Get info about GMAT scores, scholarships, and MBA tuition.
The head of Hong Kong University of Science and Technology said he and school staff decided after. refer to the island either as a Chinese province or as Taiwan, China. "As I have reiterated many.
and Taiwan (0.4 per cent). About one-third of all 2019/2019 students, or 10,355 students, were first-year/newly registered.
Scott Community College Continuing Education Jeffery Boyd, provost of the Norfolk campus of Tidewater Community College. professor and chair in the department of education at Elizabethtown College, to an additional post as dean of the School. Tarrell Portman, dean of
"Most of these movements have been motivated to some degree by a threat of loss," said Jonathan Pinckney, a researcher of non-violent resistance and protest at the Norwegian University of Science and.
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On August 20, President Morisako and his delegation visited the National Taiwan University of Science and Technology (Taiwan Tech) in Taipei and held the.
. to advance Taiwan in embracing digital currencies and other blockchain innovations by partnering with Taiwan University of Science and Technology to launch a comprehensive series of blockchain.
Taiwan's Ministry of Science and Technology (MOST) has announced that the National Central University's Photovoltaic Efficiency Verification Laboratory (PVEVL) has improved its ability to test the.
Taiwan has complained about a decision by the London. during a recruitment fair organised by the Taiwanese student union at Hong Kong University of Science and Technology.
A study by Wan-Yu Lin of National Taiwan University and colleagues. Funding: This study was supported by the Ministry of Science and Technology of Taiwan (grant number MOST 107-2314-B-002-195-MY3.
Kobe Paras caught fire for 37 points, Jun Manzo came through in the endgame, and the Fighting Maroons came out on top of Chien Hsin University of Science and Technology, 97-93, Sunday in Taiwan for.
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Release Notes¶
Release Highlights 2019.Oct¶
Spruce TK: A new toolkit for biomolecular structure preparation¶
The 2019.Oct release introduces Spruce TK. Spruce TK takes experimental biomolecular structure data in either PDB or mmCIF formats, and prepares the structures for use with downstream modeling applications, such as docking with FRED or HYBRID, pose prediction with POSIT, identifying favorable and unfavorable waters with SZMAP or free energy calculations using molecular dynamics simulations.
With Spruce TK, users can easily prepare proteins using either C++ or Python APIs (see OEMakeDesignUnits), where the output of the file is the recently developed OEDesignUnit class and is serialized to a new OEDU file format. The prepared system is componentized into molecular categories including protein, ligand, nucleic, solvent, and many other molecular types common to biomolecular experiments. By default, hydrogens are added to systems using a tautomer search for any ligand, cofactor, or other non-standard residue molecules. In addition, the system is split into distinct biological units, and all final design unit structures are superposed into the common frame of reference of a parent structure. For more details, see Spruce theory.
Spruce TK has been tested across a broad range of industry-relevant targets. It has been used in virtual screening and molecular dynamics simulations in Orion, as well as to prepare structures for loading into the MacroMolecular Data Service (MMDS).
OEChem TK: Fast Substructure Search¶
Substructure search is a fundamental task in cheminformatics. OEChem TK now provides improved substructure search capability, allowing users to search tens of millions of molecules in seconds.
OEChem TK uses the screen-based approach to accelerate the search process. Screens are bit vectors encoding global and local features of molecules. They are prebuilt and can be used to rapidly eliminate structures that could not be matched to a query molecule. Only molecules that pass the screen are subjected to the computationally more expensive atom-by-atom matching for validation. OEChem TK provides three types of built-in screens based on the source of the query molecule: MDL, SMARTS, and Molecule. All screens are rigorously tested using diverse sets of queries and multiple molecule databases to ensure that they do not eliminate true positive matches.
The new multi-threaded substructure search can be performed in two modes: in-memory and molecule-database. The in-memory mode provides the fastest way to search a dataset, but it is memory-intensive as it holds both screens and molecules in memory. The molecule-database mode keeps only the screens in memory; only molecules with unmatching screens have to be loaded into the memory. This method can be slower but uses significantly less memory, allowing users to search larger datasets.
|screen generation performance
|substructure search performance
See the Molecule searching chapter of OEChem TK for examples using the new OESubSearchDatabase class. For the full list of new preliminary APIs, see OEChem TK 2.3.0.
The 2019.Oct release incorporates the SMIRNOFF small molecule force field from the Open Force Field Initiative into OEFF TK. The force field can handle almost all pharmaceutically relevant chemical space.
The SMIRNOFF force field differs from traditional force fields principally in the data representation of the chemistry. It uses extended SMARTS strings for parameters instead of atom types, greatly reducing the number of interdependent parameters. It currently adopts the functional form of the AMBER force field, but the Open Force Field Initiative is actively examining improvements to this. OEFF TK intends to include the most up-to-date version of the force field in its own releases whenever possible.
General Notices¶
- This is the last release to support macOS 10.12. Full support for macOS 10.15 will be added in the next release.
- This is the last release to support RHEL6. Full support for RHEL8 will be added in the next release.
- The 2019.Oct release skips Java support for macOS. For Java support on RHEL6, please contact firstname.lastname@example.com.
- A new search engine that provides better hits and shows results in a much cleaner format has been added to the documents.
- The 2019.Oct release now uses SWIG 3.0.12 for generating C#, Java, and Python wrappers. C# and Python use SWIG's built-in support for wrapping C++ std::vector and string types.
Detailed Release Notes¶
OEChem TK 2.3.0¶
New features (Preliminary)¶
- The following preliminary APIs have been added to perform fast substructure searches:
- A new class, OESubSearchScreen, has been added that stores bit-vector screens. In addition, a new OESubSearchScreenType namespace and OESubSearchScreenTypeBase class have been added that handle various screen types.
- Two new low-level functions, OEMakeSubSearchQueryScreen and OEMakeSubSearchTargetScreen, have been added that generate query and target molecule screens, respectively. The OEScreen low-level function can be used to determine whether a query molecule can potentially be matched to a target molecule by comparing their screens.
- A new function, OEIsComplementaryScreenType, has been added that determines which screen types are suited for a specific query molecule.
- New helper functions, OESameSubSearchScreenTypes, OEGetSubSearchScreenType, and OEIsValidSubSearchScreenString, have been added.
- A new OECreateSubSearchDatabaseOptions option class and OECreateSubSearchDatabaseFile function have been added that pre-generate databases for substructure search. A new OEIsValidSubSearchDatabase function also has been added that checks whether a molecule file is valid for substructure search.
- The OESubSearchDatabase class is designed to perform rapid substructure searches. A new OESubSearchDatabaseType namespace has been added to this class that enables various database implementations.
- A new class, OESubSearchQuery, has been added that sets up search queries. In addition, a new OESubSearchResult class has been added that reports the progress of the search and retrieves the matches.
- A new OESubSearchStatus namespace and OESubSearchStatusToName helper function have been added that monitor the search progress.
- A new low-level function, OEReadCIFFile, has been added that reads both small and macromolecule Crystallographic Information File (CIF and mmCIF) formats.
New features¶
- Two new classes, OEConfRMSDOptions and OEConfRMSD, have been added that set up OEConfRMSD calculations and provide fast RMSD calculation of conformers of the same molecule, respectively.
- A new function, OEFastaToMol, has been added that converts a FASTA sequence into a molecule.
- A new optional sorting argument has been added to the OEGetNearestNbrs function that allows returned atom pairs to be sorted based on distance.
- OEIsAlphaCarbon has been deprecated. The OEIsCAlpha predicate should be used instead.
- New OEUncolorMol overload functions have been added to OEMCMolBase. A new constant, OEUncolorStrategy.RemoveDimension, has been added that invalidates 3D coordinates and sets the dimension to 0 when uncoloring molecules.
- Support has been added to OEReadMolecule that enables reading both CIF and mmCIF files.
- Updates have been made to the OEFormat namespace to include new CIF and mmCIF formats. Corresponding updates have also been added to OEIFlavor and OEOFlavor.
- Updates have been made to the OEResidueIndex namespace to include residue IDs for metals observed in PDB files.
- The formal charge assignment for less common metals observed in PDB files has been expanded.
- Updates have been made to the OEExprType namespace to allow for more fuzzy searches. For example, OEExprType.ElemMinHCount or OEExprType.ElemMinDegree can now be used to specify an atom's minimum hydrogen count or minimum degree.
- Changes have been made to the OEResidue class to support the mmCIF format.
These changes include the following three new string member variables, with the appropriate
getter and setter functions:
- SequenceID captures the mmCIF field, label_seq_id, which is the sequential number of residues from 1.
- ExtChainID captures the fact that the previous chainID in the auth_asym_id field can now have multiple characters. The OEResidue.GetChainID function now returns the first character of the ExtChainID variable, and OEResidue.SetChainID now overwrites and sets the ExtChainID.
- SubChainID captures the label_asym_id field, which commonly seems to be a further subdividing of the auth_asym_id field.
Minor bug fixes¶
- A bug that caused OEWriteMolReturnCode.Success to be returned even though an invalid output stream was used has been fixed.
- A bug that caused broken perception after implicit hydrogen assignment in the OEAssignImplicitHydrogens and OEAssignMDLHydrogens functions has been fixed.
- Handling of partially resonant nitrogen stereo perception in OE3DToAtomStereo and OE3DToInternalStereo has been improved.
- An issue that caused OEIsCTerminalAtom to misperceive a minor number of C-terminal atoms has been fixed.
- Unpaired interactions are no longer triggered on ligands due to nearby water molecules. Similarly, water molecules can no longer present as having unpaired interactions.
Python-specific changes¶
- Support for making custom MCS scoring functions from OEMCSFunc has been added.
- New functions, OEGetBytesFromGrid, OEGetScalarGridFromBytes, and OEGetSkewGridFromBytes, have been added to support the conversion between byte[] and grids (OESkewGrid or OEScalarGrid).
- OETrans.Extract is now available in Python.
Java-specific changes¶
- New functions, OEGetByteArrayFromScalarGrid, OEGetByteArrayFromSkewGrid, OEGetScalarGridFromByteArray, and OEGetSkewGridFromByteArray, have been added to support the conversion between byte[] and grids (OESkewGrid or OEScalarGrid).
Documentation changes¶
- Two new examples have been added that demonstrate performing fast substructure searches:
- A new example program, Printing protein amino acids histograms, has been added that demonstrates printing a histogram of the occurrences of various amino acids in a protein.
- The Print OEChem and format information example program has been updated to demonstrate using the OEToolkitsGetRelease function.
- New code snippets have been added to the OEConfRMSD class that demonstrate finding the two conformers of a molecule with the smallest RMSD.
- New code snippets have been added to the OEFastaToMol function that demonstrate creating a molecule from a FASTA sequence.
- New code snippets have been added to the section, String Input and Output, that demonstrate reading and writing molecules from memory buffers.
- New code snippets (in C++ and Python) have been added to the OEMCSFunc class that demonstrate using custom scoring functions.
- OEChem TK examples have been cleaned up to use the new C++11 style.
OEBio TK 2.3.0¶
New features¶
The following APIs have been added for perceiving non-ideal hydrogen bond interactions (i.e., hydrogen bonds with long donor-acceptor distances or poor geometries):
A new functor, OEIsNonIdealHBondInteractionHint, has been added that easily identifies non-ideal hydrogen bonds.
New interaction types, OEHBondInteractionHintType.NonIdealLigandAccepts and OEHBondInteractionHintType.NonIdealLigandDonates, have been added.
The following methods have been added that customize the non-ideal hydrogen bond perceptions:
- OEPerceiveInteractionOptions.SetMaxNonIdealDonorAngle and OEPerceiveInteractionOptions.GetMaxNonIdealDonorAngle
- OEPerceiveInteractionOptions.SetMaxNonIdealAcceptorAngle and OEPerceiveInteractionOptions.GetMaxNonIdealAcceptorAngle
- OEPerceiveInteractionOptions.SetMaxNonIdealHBondDistance and OEPerceiveInteractionOptions.GetMaxNonIdealHBondDistance
A new functor, OEIsHetAtom, has been added that identifies atoms with the hetero atom property in an OEResidues object.
A new functor, OEIsDisulfideBond, has been added that identifies disulfide bonds.
A new function, OECalculateDPI, has been added that calculates the diffraction-component precision index (DPI) value.
New categories, OEResidueDatabaseCategory.Lipid and OEMolComplexFilterCategory.Lipid, have been introduced that enable splitting lipids from a system.
A new method, OEInteractionHintContainer.DeleteInteractions, has been added that removes all interactions.
The functional group perception in OEPlaceHydrogens has been improved.
Minor bug fixes¶
- Perception of hydrogen bonds involving sulfur and anions in OEPerceiveInteractionHints has been improved.
- The precedence of OEInteractionHint perception has been improved. Chelation interactions now take precedence over charge-charge interactions.
- A check has been added to the OEPlaceHydrogens function that causes it to exit early if two heavy atoms are within 0.5A of each other, since this is considered to be bad input and causes unspecified behavior.
OESystem TK 2.3.0¶
New features¶
- The performance of OEGetDataType, especially on Windows, has been improved. OEGetDataType is now at least 500X faster when used with a single thread and about 2X faster with many simultaneous threads on Windows.
- A new method, OEBitVector.CountRangeBits, has been added that identifies the number of bits that are set to 1 in the given bit range.
- A new class, OEConsoleProgressTracer, has been added that tracks the current progress of a task.
- A new function, OEStringEquals, has been added that determines whether two strings are equivalent using a case-insensitive comparison.
- A new function, OEGeom3DReflectCoord, has been added that reflects coordinates around a plane for a hydrogen atom.
- A new function, OEBitIsPowerOf2, has been added that determines if a bitmask is a power of 2.
OEPlatform TK 2.3.0¶
New features¶
- A new OEToolkitsGetRelease function has been added that displays the release name of the overall toolkit version being used.
OEGrid TK 1.6.4¶
- Minor internal improvements have been made.
OEDepict TK 2.4.3¶
Minor bug fixes¶
- The signature of the OECreateWin32GraphicsImage function has been changed to use std::shared:ptr.
- SVG group IDs and names are now limited to 64 characters.
Python-specific changes¶
- User-defined atom and bond SVG markings are now supported in Python. See the examples in the OEAtomSVGMarkupBase and OEBondSVGMarkupBase base classes.
OEDocking TK 1.4.1¶
New features¶
- Two new result classes, OESinglePoseResult and OEPositResults, have been added that better report OEPosit-generated pose results.
- A new class, OEPoseOptimizer, has been added that optimizes an already generated pose to reduce clashes.
- A new method, Dock, has been introduced that provides greater flexibility in reporting the generated pose results. The OEDocking::OEPosit::DockMultiConformerMolecule method is now deprecated.
- Two new methods, AddReceptor and ClearReceptors, have been added to the OEPosit class that enable using multiple receptors in a single calculation.
- A new function, OEHasClash, has been added that allows clash detection.
- The following new methods have been added to the OEPositOptions class that enable working with multiple receptors as well as further refinement of generated poses:
- A new namespace, OEAllowedClashType, has been added that defines constants for various allowed clash types.
- A new namespace, OEPoseRelaxMode, has been added that defines if and when a relaxation should be performed.
- A new constant, OEDockingReturnCode.NoValidNonClashPoses, has been added that indicates that no non-clashing poses are found.
- A new function, OEDockingReturnCodeGetName, has been added that converts OEDockingReturnCode to a meaningful string.
- A new function, OEPositMethodGetName, has been added that returns the name of an OEPositMethod in a string format.
Major bug fixes¶
- A rare crash that occurred during docking calculations in DockMultiConformerMolecule has been fixed.
- OEPosit no longer fails to generate poses due to unspecified stereo in the input molecule.
Minor bug fixes¶
- OEMakeReceptor now returns an empty receptor molecule when it fails.
- OEGetEstimatedPositProbability no longer crashes when a failure occurs during conformer generation.
Documentation changes¶
- Two new examples have been added in the sections, Using Multiple Receptors and Receptor Flexibility, that demonstrate new POSIT features for working with multiple receptors and for further refining generated poses, respectively.
- Docking examples have been updated for better coding practices that check the return code status of docking and print out any errors.
FastROCS TK 1.10.1¶
New features¶
- A new function, OEFastROCSGPUStatus, has been added that interrogates the status of the GPU and returns a code from the OEFastROCSReturnCode namespace. The return codes now allow for more specific error reporting of the GPU system.
Major bug fixes¶
- An issue that caused OEFastROCSOrientation.Subrocs to fail to apply the correct number of starts to the color calculation has been fixed.
- OEShapeDatabase.SetColorGridSpacing had been broken after the previous major version change. This has been fixed.
- OEShapeDatabaseOptions.SetLimit now returns all N overlays of all conformers and orientations when used in conjunction with OEShapeDatabaseOptions.SetMaxOverlays set to 0 and OEShapeDatabaseOptions.SetMaxConfs set to 0.
- The default is now to run reference Tversky when running OEShapeSimFuncType.Tversky. For more details about Tversky similarity scoring, see the Molecular Shape section of the Shape TK theory documentation.
Minor bug fixes¶
- OEShapeDatabaseOptions.SetNumInertialStarts is no longer order-dependent when using alternative starts.
- When running with Tversky similarity scoring, only a single warning about Tversky scores being greater than 1.0 will ever be thrown unless the debug error level is being used.
Grapheme TM TK 1.4.0¶
New features¶
New OEDrawIridiumData functions have been added to visualize OEIridiumData.
hover cursor over graph
Example of visualizing Iridium data
A new function, OERenderActiveSite, has been added that depicts the new non-ideal hydrogen bonds. For more details about these interactions, see the OEIsNonIdealHBondInteractionHint functor.
- A new overload of OEPrepareAlignedDepictionFrom3D has been added that generates 2D coordinates of a molecule driven by the 3D overlay of the shape query display object.
GraphSim TK 2.4.3¶
New features¶
- A new method, OEFastFPDatabase.GetMoleculeIndex, has been added.
Minor bug fixes¶
- OEIsValidFPTypeString no longer throws an error and always return false if the given string cannot be interpreted.
Lexichem TK 2.7.0¶
- Minor internal improvements have been made.
OEMedChem TK 1.1.1¶
New features¶
The following APIs for fast multithreaded generation of matched pair indices, introduced in the 2018.Oct release, have graduated from preliminary API to stable API status:
- OECreateMMPIndexFile function
- OECreateMMPIndexStatus class
- OECreateMMPIndexOptions class
They are now also available in Python, Java, and C#.
Documentation changes¶
- The following examples that create a Matched Molecule Pair index were modified to fix an issue with the SD data handling (options -keepSD, -clearSD, -allSD):
MolProp TK 2.5.3¶
New features¶
- Two new functions, OEGetHBondDonorCount and OEGetHBondAcceptorCount, have been added that count the number of hydrogen-bond donors and acceptors in a molecule.
- Two new functions, OEGetLipinskiDonorCount and OEGetLipinskiAcceptorCount, have been added that determine the number of donors and acceptors in a molecule based on the definition from the work of Lipinski ([Lipinski-1997]).
- A new function, OEGetLongestUnbranchedHeavyAtomsChain, has been added that determines the size of the longest chain of heavy atoms in a molecule.
- A new function, OEGetLongestUnbranchedCarbonsChain, has been added that determines the size of the longest chain of all carbons in a molecule.
- A new function, OEGetHalideFraction, has been added that determines the percentage of molecular weight from halides.
- A new function, OEGetAnionicCarbonCount, has been added that determines the number of anionic carbons in a molecule. New filter options, MIN_ANION_C and MAX_ANION_C, have also been added that filter out anionic carbons.
- A new function, OEWritePropertyDataToCSV, has been added that writes molecular properties to the output in the OEFormat.CSV format.
- Two new functions, OEGetNumUnspecifiedAtomStereos and OEGetNumUnspecifiedBondStereos, have been added that filter out molecules with unspecified atom and bond stereos. New filter options, MIN_UNSPECIFIED_ATOM_STEREOS, MAX_UNSPECIFIED_ATOM_STEREOS, MIN_UNSPECIFIED_BOND_STEREOS, and MAX_UNSPECIFIED_BOND_STEREOS, have also been added.
Minor bug fixes¶
- The XLogP calculation by the OEGetXLogPResult function for molecules with explicit hydrogens has been fixed.
Documentation changes¶
- A new program, Write molecular properties to a CSV file, has been added that demonstrates writing molecular properties to an output file in the OEFormat.CSV format.
New features¶
A new class, OESmirnoff, has been added that facilitates creating a SMIRNOFF force field (release 0.3), a small-molecule force field that uses extended SMARTS patterns for its chemical representation of parameters (https://openforcefield.org/). The following classes have also been added that define interaction functions using the functional forms in the SMIRNOFF force field:
The following classes, derived from the parent class OEInteractParams, have been added to create a set of force field parameters for a given molecule:
The OEFFParam namespace has been expanded to support SMIRNOFF force field torsion potential.
A new method, GetIterLimit, has been added that allows assessing the state of an OEOptimizer0.
Two new methods, GetIterLimit and GetTolerance, have been added that allow assessing the state of an OEOptimizer1.
Two new methods, GetIterLimit and GetTolerance, have been added that allow assessing the state of an OEOptimizer2.
Major bug fixes¶
- A memory leak in OEInterAdaptor has been fixed.
- A memory leak in OEAM1 has been fixed.
Documentation changes¶
- Theory documentation for SMIRNOFF has been added (see SMIRNOFF).
- A new program, Single ligand in vacuum, has been added that demonstrates calculating energy and optimizing a single ligand in vacuum.
- The following example programs have been corrected:
- Single ligand in vacuum
- Energy components of a single ligand in vacuum
- MMFF interactions of a single ligand
- Protein-ligand optimization with MMFF
- Protein-ligand optimization with MMFFAmber
- Optimizing a single ligand with fixed atoms
- Optimizing a single ligand torsions
- Optimizing rigid ligand in protein
Omega TK 2.9.1¶
New features¶
- The following new methods have been added to the OESliceEnsembleOptions class to make it more efficient with large macrocycles and energy-optimized structures:
- A new class, OEConfSlicer, has been added that complements the OESliceEnsemble method. In addition, a new overload has been added to OESliceEnsemble that provides broader functionality by working with an OESliceEnsembleOptions object.
- Deduplication of conformer ensembles in OEMacrocycleOmega has been improved by replacing two preliminary API methods, OEConfGen::OEMacrocycleOmegaOptions::SetDeduplicateScanOptions and OEConfGen::OEMacrocycleOmegaOptions::GetDeduplicateScanOptions, with OEMacrocycleOmegaOptions.SetSliceEnsembleOptions and OEMacrocycleOmegaOptions.GetSliceEnsembleOptions, respectively.
Major bug fixes¶
- OEMacrocycleOmega.Build now generates conformer ensembles that are centered and aligned to each other, and with better deduplication.
- An issue that occasionally caused knotted conformations of some complex molecules generated with OEOmega.Build has been fixed.
Minor bug fixes¶
- OEOmega.Build now properly adds hydrogens to single heavy atom molecules.
- Two preliminary API classes, OEConfGen::OEDuplicateScanner and OEConfGen::OEDuplicateScanOptions, have been removed.
- Two preliminary API methods, OEConfGen::OETorDriveOptions::SetIncludeInput and OEConfGen::OETorDriveOptions::GetIncludeInput, have been removed.
- Defaults for OEOmegaOptions.SetEnumNitrogen and OEOmegaOptions.SetSampleHydrogens in the OEOmegaSampling.Dense mode have been changed from OENitrogenEnumeration.Unspecified and false to OENitrogenEnumeration.All and true, respectively.
- An issue regarding the OEOmegaOptions.SetEnergyWindow not being properly honored for some molecules with OEOmega.Build has been fixed.
- Fragment conformations for CCN and CN have been updated in the built-in fragments library to properly reflect the tetrahedral geometry.
- Occasional failure to generate conformations for molecules containing chiral N=N or C=N bonds has been fixed.
Quacpac TK 2.0.2¶
New features (Preliminary)¶
- A new preliminary class, OEDesignUnitCharges, has been added that charges an OEDesignUnit.
New features¶
- A new optional argument, warts, has been added to the OEFormalChargeOptions constructor. Two new methods, OEFormalChargeOptions.GetWarts and OEFormalChargeOptions.SetWarts, have also been added that control whether to add wart to the title of each charge state.
Shape TK 2.0.4¶
New features¶
- Two new methods, SetMultiplier and GetMultiplier, have been added to the OEColorOptions class that enable use of a multiplier to the calculated color scores.
Minor bug fixes¶
- The Python example in the section, Calculating NxN scores, has been fixed.
- The multithread version of the Python example in Best Optimization Result has been fixed.
Spicoli TK 1.4.7¶
- Minor internal improvements have been made.
Spruce TK 1.0.0¶
New features¶
The OEExtractBioUnits function has become a stable API. The final implementation includes an options class, OEBioUnitExtractionOptions, to control its behavior.
A new function, OEMakeDesignUnits, has been added that generates OEDesignUnit from structures read from PDB or mmCIF files. The function takes a number of options to control its behavior; therefore, the following options classes have been defined:
- OEMakeDesignUnitOptions: a high-level options class that holds the options classes below.
- OEDesignUnitPrepOptions: a high-level options class that holds other options classes, determining how a design unit is prepped.
- OEDesignUnitBuildOptions: a low-level class that sets whether to build caps and missing sidechains.
- OEProtonateDesignUnitOptions: a low-level class that sets whether and how to protonate the design unit, including whether to generate tautomers.
- OEDesignUnitSplitOptions: a low-level class that determines how to handle alternate locations, how a system is split, locating the ligand, etc.
The OEMakeDesignUnits function also takes the OEStructureMetadata class as input. The OEStructureMetadata class holds experimental data if known and can be used to indicate which is the ligand, what the sequence of the protein is, and other relevant pieces of information.
The function OEMakeDesignUnits is a high-level function that works on the two intermediate functions, OEMakeBioDesignUnits and OEEnumerateSites, which can be run separately if intermediate results are desired. The high-level OEMakeDesignUnits function has a deduplication step built in; this function is highly recommended.
A new function, OEMakeDesignUnit, has been added that creates an OEDesignUnit.
A new function, OEProtonateDesignUnit, has been added that ensures that protons in an OEDesignUnit are optimized. The high-level function OEMakeDesignUnits calls this by default unless it is turned off in options.
The OEBuildSidechains function has been updated to allow building all possible clusters even if one fails due to clashes. The function still returns false in this case.
Major bug fixes¶
- An issue in the OEExtractBioUnits function that caused a segfault due to an improper PDB header format has been fixed.
- An issue in the alternate location expansion that left atoms on top of each other due to unconventional location definitions has been fixed.
Minor bug fixes¶
- An issue with OECapTermini preventing caps from being built in some very specific instances has been fixed.
- OEBuildSidechains no longer builds sidechains on packing residues.
Documentation changes¶
- A new example, Creating OEDesignUnits from a PDB file, has been added that illustrates the usage of the high-level OEMakeDesignUnits function for biomolecular structure preparation. This example takes a PDB file as input and outputs a set of fully prepared OEDesignUnit objects to a temporary file.
Szmap TK 1.4.6¶
- Minor internal improvements have been made.
Szybki TK 2.1.0¶
New features¶
- OESzybki.SetProtein has been updated to return a Boolean, allowing failures to be handled in code.
- Szybki can now perform energy optimization using a SMIRNOFF force field (https://openforcefield.org/).
Minor bug fixes¶
- The default EnergyWindow for conformer generation in OEFreeFormConfOptions is now consistent with that in OEOmegaOptions in the OEOmegaSampling.Dense mode.
- Two methods in OEFreeFormConfResults, PrintTxt and PrintCsv, have been modified to widen the scope of the associated streams.
Documentation changes¶
- A new example program, Optimization of a bound ligand in a partially flexible receptor, has been added.
- A new example program, Single ligand in vacuum using SMIRNOFF, has been added.
Zap TK 2.3.6¶
Python-specific changes¶
- The runtime error that occurred when using OEMakeETGrid in Python has been fixed.
Previous Release Highlights¶
- OEToolkits 2019.Apr
- OEToolkits 2018.Oct
- OEToolkits 2018.Feb
- OEToolkits 2017.Oct
- OEToolkits 2017.Jun
- OEToolkits 2017.Feb
- OEToolkits 2016.Oct
- OEToolkits 2016.Jun
- OEToolkits 2016.Feb
- OEToolkits 2015.Oct
- OEToolkits 2015.Jun
- OEToolkits 2015.Feb
- OEToolkits 2014.Oct
- OEToolkits 2014.Jun
- OEToolkits 2014.Feb
- OEToolkits 2013.Oct
- OEToolkits 2013.Jun
- OEToolkits 2013.Feb
- OEToolkits 2012.Oct
- OEToolkits 2012.Jun
- OEToolkits 2012.Feb
- OEToolkits 2011.Oct
- OEToolkits 2011.1
- OEToolkits 1.7.4
- OEToolkits 1.7.2
- OEToolkits 1.7.1
- OEToolkits 1.7.0


text: Nothing's prettier than pink - and this bouquet is bursting with it! Delicate roses and alstroemeria look even more delightful in our brilliant gem vase, a gift she can enjoy for years to come as an elegant votive candle holder! Includes pink roses, pink alstroemeria, pink and white carnations, bupleurum and variegated pittosporum. Delivered in Giftblooms brilliant gem votive. Orientation: one-sided


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The hike I took this morning would have gone much easier if I had someone next to me as I climbed. As it was, I told myself – just get to the tree, just get to the rock, just get to the next curve. And with each baby step, I climbed higher. Read More
Day 29 – Down to the Wire…
I began my 31 Day Writing Challenge when I was visiting family in Carson City, NV. During the month I walked, wrote, had friends visit me, I visited friends and enjoyed the glorious light and colors. Now at the end of the month, the colors are fading, the light is dimming and there's a melancholy… Read More
Day 27 – Time to Goof Off
Well, here I am again. Still exercising and still walking and as you may have guessed… still socializing. It seems when I have friends in my plans, I forget to blog. Earlier this month I spaced out blogging when a longtime friend was passing through my city and she spent the night before heading home. Yesterday… Read More
Day 11 – Showers of Gold
I had a strange bike ride this morning. I rode about 3 miles and then came to a detour on the bike path. I decided to turn around and head west. I rode for about 2 miles and came upon LOTS of people running. It wasn't a race – just a running club. There must… Read More
Day 8 – Mindful Walking
Walking on nearby trails is a fun way to get in my daily exercise. I'm able to move fast, enjoy the scenery and avoid traffic. Sometimes I have to avoid bikes and strollers and dogs but that's ok because sometimes I am on the bike and scooting around the walkers. Sometimes I enjoy walking alone… Read More
Day 6 – Shall We Walk?
Some sort of movement for 31 days has been my challenge since Oct 1 (a mere 6 days ago.) That actually isn't the hard challenge for me – blogging for 31 days is. My movement days – walking, working out, hiking, biking are part of my routine – though this public view will make… Read More
A Month of Movement!
Write 31 Days… You bet I can! I got lucky! I learned about this 31 Day Challenge after agreeing to partner up with my sister-friend so we could hold each other accountable for taking good care of our bodies. My goal during the month of October 2015 is to walk 4 miles daily or move… Read More


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My sweet little Lucy Goose had surgery on her ear yesterday. Poor girl. But you should see how cute it is when she tries to figure out how to scratch at her stitches with that cone on.
Tag: Lucy
Pillow Thief
This is what happens when I get up to go to the bathroom...
The Cutest Puppy Ever
Hello friends! I'm starting a new blog feature this week called "Photo Friday." Basically, I'll just post a photo that I'd like to share with you. It may or may not be a photo that I snapped myself. I hope you enjoy! This is my sweet and crazy Boston Terrier, Lucy. This photo was taken … Continue reading The Cutest Puppy Ever
My Dog's Christmas List
Alternate Title: The Christmas Wish List of Lucimus Goosimus Varcinius Maximus Roder (Lucy to her friends) This is Lucy. As you can see, she is quite adorable. That ridiculous nickname above is courtesy of my husband. She also goes by Lucy Goose, Snorty McSnortferson, Stanley the Grumpy Old Man, and Puppy. I'm pretty sure I gave … Continue reading My Dog's Christmas List


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Peels/ Vegetable Gels can improve the skin's appearance. In this treatment, a solution is applied to the skin, which makes it a "blister" and eventually peel off. The new skin is usually smoother and less wrinkled than the old skin.
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Date: Thursday, July 7, 2016
Time: 12:00pm - 2:00pm
Venue: ACCJ Tokyo Office, Boardroom
Speaker: John Darwin Van Fleet (Assistant Dean, USC Marshall School of Business, Executive Director, Global Executive MBA, Shanghai GEMBA)
Member Fee: ¥2,500 Guest Fee: ¥3,500
Meal: Lunch
Registration/Cancellation Deadline: Monday, July 4, 2016
Hosting Committee(s): Special Events
Prof. John Darwin Van Fleet on the History of Tokyo and Current Japan-China Relations.
Join us on July 7 for a luncheon of learning with Prof. John Darwin Van Fleet, Assistant Dean, USC Marshall School of Business in Shanghai. Professor Van Fleet recently published "Tales of Old Tokyo" and is a regular contributor to various publications on the topic of Tokyo and China-Japan relations.
This will be a unique opportunity to learn about Tokyo from 1853 to 1964. This remarkable time marks the end of Edo Period isolation and the beginning of Japan's entrance onto the global stage. Stories and knowledge from this period can provide deep insight into working with Japan and Japanese companies from an international point of view.
Professor Van Fleet's experience in Japan, knowledge of Tokyo's history, and update from Shanghai will certainly provide great food for thought and add to your perspective on your experience here.
The luncheon will be held at the ACCJ office for a more informal and personal discussion with the Author.
To learn more about the speaker, click here.
Timothy Connor, Ruth Marie Jarman, Aron Kremer, Robert Melson, Co-Chairs
Debbie Howard, Board Liaison
ACCJ Special Events Committee
NOTE 1: This event is OFF THE RECORD.
NOTE 2: If you cancel after the stated deadline, the full meeting fee will be charged to your account. Sorry, no substitutions or walk-ins.


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HEROES Camp
Heroes Camp is an 5 week summer camp aimed at providing a fun, engrossing and spiritually edifying educational environment. Students enrolled will not only be immersed in various Art, Science, Technology, and Sports activities, but will also be enriched with myriad lessons and activities focused on creating new passions in the arts and sciences. All of the available lessons are incredibly hands on and engaging. Students will be able to participate in projects ranging from water colors and mural paintings to gardening, instrument making, sock monkey crafting, and excavating fossils to name a few. We also provide a wide range of physical activities, from your traditional sports like soccer and basketball to our zany laughter-filled games of "Star Battles", "Tarzan", "Boomer Ball", and "Kaboom!" Each of the 5 weeks is theme based, and parents and children will have the option to sign up for the themes that best fit their goals/interests. No matter the interest, we will provide fun and fulfilling activities for any child whether they be staying just one or all five weeks!


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(5) Private Psychology Tutors offering lessons, class and homework help in Bourbon
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After the House passed their Farm Bill today, it appears that their version on the Senate version are not too far apart. The key points for both are:
- An elimination of all direct farm payments
- A reduction in CRP acreage to either 24 or 25 million acres
- Consolidation of many farm programs
- A Price Support program that guarantees a farmer a minimum price for their crop, or
- A Revenue Program that a farmer can elect (they have to elect one or the other).
The Price Support program is either based on a price set by Congress (the House version) or based on the average Olympic average of the prior 5 years of prices (the Senate version). If a farmer elects the Price program, they cannot participate in the Revenue program and vice versus.
A couple of key differences is a payment limitation in the Senate of $50,000 per person for the Senate and $125,000 for the House.
The Senate also eliminates these payments if your adjusted gross income is over $750,000 while the house boosts this to $950,000. This will most likely make the accounting simpler than it is now since you will most likely only need to look at the bottom line income shown on the bottom of your Form 1040 page 1.
We would guess that a final farm bill will be ready for a vote in the next week or so, but with Memorial Day only a week from Monday, who knows long Congress will take off for that Holiday.
We will keep you informed.


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|Fri 22 Mar 2019, 7:00pm–10:30pm
Additional fees may apply
Twenty years ago in 1999, Eugene 'Hideaway" Bridges, made his first Australian visit and ever since those first sellout shows he has been coming back - at least once a year (sometimes twice), right through until 2019. During that time he has played in every Australian State, every capital city and numerous regional and country towns. It's testament to his popularity and the many friends he has made here that he returns every year for the Australian summer, always with something new but always with a wonderful songbook of original tunes that he has written and recorded over the past two decades.
Eugene "Hideaway" Bridges has been a man on a mission since 1966 when his Dad Otheneil Bridges Sr, *(aka "Hideaway Slim") gave him his first guitar. Eugene sees himself as an important link between the past, present and future of the blues. This has always been a part of his message and the music that he both writes and recalls from the greats - the elder musicians he has looked up to for over 50 years.
On each show around the world Eugene brings into view the 'yesterday' that he feels has been overlooked along the way, but needs to be heard. Eugene's music goes way back to the sounds of the Church and his gospel roots—where many of the musical styles we hear in blues, jazz, pop, rock and country originated.
Determined never to let this story fade away or be forgotten, Eugene dedicates part of his show to many of the greats who have influenced him like B.B. King and Sam Cooke. His latest CD 'Live in Tallahassee' is an authentic down home live recording in which Eugene takes you to the classic old juke joint, just like it was when he was a small boy touring with his Daddy. It's a performance recalling the old days when you just sang from the heart, even if you were just sitting on the front porch.
In 2017, The US Jus' Blues Music Foundation announced that Eugene Hideaway Bridges was to be their 2017 honoree for the Albert King Lifetime Award, "The Lucy Award", for his outstanding contributions in continuing to keep the style of traditional Blues alive.
Doors open: 7pm
Show starts: 8pm
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It Wasn't a Cold…
I got some Cold/Flu like symptoms last week so I went to the drug store and got myself the usual suspects. In my case, you down the Buckleys, keep some HALLS in your pocket, and shoot the Nyquil before bed. I did for that for 5 days, and everyday, it seemed to get worse. I also kept having fevers, going hot and then cold almost randomly. Kelly told me to go see a doctor. I'm glad I did. After the doctor smacked me on the forehead and face a few times, did some probing, and checked out my throat and breathing, he concluded that I had Sinusitis. Sinu…what?
Sinusitis is actually a bug that presents itself totally like a cold. You get cold like symptoms at first, then you get huge headaches like your head is going to explode, and then fever. Then your sinuses get totally infected. Eww! I've actually still got a low grade fever and my head does feel like its going to explode. I tried to be a man and grunt it out, but I wasn't going to win this fight without help.
The doctor prescribed some Nasonex and some Anti-Biotics and sent me on my way. He also refilled my muscle relaxant prescription from my car accident. My neck still tends to stick and get tense when I go to bed. It feels like I'm shrugging my neck but can't turn it off so the muscle relaxants help a lot. Along with my mind being a bit burnt out, my body decided to join the big mess. Goes to show how powerful that mind really is. Hopefully, after I finish off these drugs, I should be right as rain, and ready for my trip to Taiwan for the COMPUTEX Show.


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