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In the heart of the city, the Millennium Hotel Glasgow is only a short walk from The Corinthian, Buchanan Street and Glasgow Queen Street station. The hotel offers a 24-hour concierge, a Brasserie serving traditional Scottish cuisine and you can relax with a drink in lounge bar. Meanwhile, its smart rooms come with Hypnos beds, flat-screen TVs, free wi-fi, tea and coffee making facilities, and en-suite bathrooms. NOTE: Due to the hotel's central location there is no drop-off zone. Care should be taken to comply with parking regulations and occasional road closures during events. Contact hotel ahead of arrival if in doubt. Enjoy a meal with family, friends, colleagues or business associates, with views of Glasgow's historic George Square. The Brasserie, on George Square, offers lunch, dinner and afternoon tea. The wine list and dessert menus offer something for everyone and will satisfy all budgets. The knowledgeable staff will gladly make recommendations. A comfortable area on the ground floor, the lounge is ideal for a quiet drink anytime of the day. This fantastic meeting point located directly beside Queen Street Station offers coffees served with shortbread and as well as a fantastic selection of cocktails and champagne. Why not sit in the beautiful conservatory overlooking George Square and watch the world go by with one of the cocktails or a glass of champagne? Queen Street Train Station is currently undergoing an exciting re-development and construction work is being carried out on nearby buildings. We are working hard to minimize disruption to our guests. The George Square entrance/exit for the station is closed, please use North Hanover Street or Dundas Street.
Enjoy a meal with family, friends, colleagues or business associates, with views of Glasgow's historic George Square.The Brasserie, on George Square, offers extensive lunch, dinner and set menus. The wine list and dessert menus offer something for everyone and will satisfy all budgets. The knowledgeable staff will gladly make recommendations.This is a lively bar which is popular with both residents and locals alike. With conservatory views of the magnificent George Square combined with a buzzing pub style atmosphere, Georgics is the perfect place to relax and unwind. It has a fantastic selection of cocktails and drinks on offer as well as light snacks starting from as little as 3.25 GBP.A sophisticated area on the ground floor, the lounge is ideal for a quiet drink anytime of the day. This fantastic meeting point located directly beside Queen Street Station offers designers coffees served with freshly made shortbread and as well as a fantastic selection of Champagne and cocktails. Why not sit in the beautiful conservatory overlooking George Square and watch the world go by with one of the cocktails or a glass of champagne?
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Similar hotels to Millennium Glasgow Hotel
Stay in the heart of Glasgow - after all, you're an Urbanite not a tourist. Z Glasgow has everything you need for a couple of nights in town. Concentrated style, an out of town price, and a prime location. The hotel is a designer conversion of an Old Printworks, with 104 bedrooms arranged around a central lightwell over ground and five upper floors. The hotel is situated in the heart of the city, right next to George Square. You choose Z Glasgow. You step outside and you're immediately immersed in the very heart of Glasgow, just steps from historic George Square with its grand City Chambers and statues of the historical great and good. You could be shopping on the style mile within 2 minutes, or enjoying one of the many restaurants and bars of the Merchant city. After heading down through the city centre your standing on the banks of the Clyde, once the life blood of the city, stroll along the riverside walk and you could be enjoying an event at the world class venues of the SSE Hydro or the SECC. A little further still and you're at the Riverside transport museum or the Science Centre
This modern 4-star hotel, in the centre of Glasgow, is next to Glasgow Queen Street station. While the O2 Glasgow and the shops of Buchanan Street are only a short walk away. The restaurant serves lunch and dinner, as well as an afternoon tea service; and you can enjoy a quiet drink in the bar. Classic en-suite rooms come with free wi-fi, satellite TV, complimentary toiletries and tea and coffee making facilities.
A smart central Glasgow hotel with an award-winning restaurantHoliday Inn® Glasgow - City Centre Theatreland hotel is close to the city's main theatres and the shops on Buchanan Street.Glasgow Queen Street and Glasgow Central railway stations are a short walk away, and nearby Buchanan Street bus station has shuttles to Glasgow Airport (GLA). If you're travelling by car, we offer discounted parking at Concert Square Car Park across the street. You can catch shows by top musicians at Glasgow Royal Concert Hall or comedy and drama at the King's Theatre, Pavilion Theatre and Theatre Royal, all within a gentle stroll. The SEE Hydro concert arena and the conference centre at the Scottish Event Campus are only 2 miles away. Our 4 meeting rooms have high-tech AV equipment and space for up to 100 guests, and our friendly and efficient team can provide catering on request.At this hotel you can enjoy:- Free WiFi- 24-hour room service- Kids stay and eat freeComfortable guest rooms all have pillow menus, USB ports for charging your devices, and 40-inch flat-screen TVs. Spacious top-floor suites feature a separate lounge and memorable city views. La Bonne Auberge, our chic, brasserie-style restaurant and bar, serves breakfast, lunch and dinner and is the perfect place for a pre-theatre treat.
Frequently asked questions
Why should I buy my travel on lastminute.com?We sell over 284,000 hotel bookings per year online to our customers since 1998, being one of the firsts in the sector.
What services can I add to my booking?During the booking process you will be offered all the services you can add:
- Our support packs
- Our service Check-in NoProblem
- Additional luggage
- Car rental
- Parking at the airport
- Transfers
At what time can I have my room? And what time do I have to leave?Check-in and check-out times vary according to the property. However, the schedules are usually as follows:
- Hours of arrival ( check-in ) from 14:00.
- Departure times ( check-out ) at 11:00.
What is the price match guarantee?If you book a hotel or city break (Flight + Hotel/ Eurostar + Hotel) on lastminute.com and you find the same product or package for less on another website within 24 hours of booking, we'll give you the difference! Subject to terms & conditions.
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Ibis Styles Glasgow Centre George Square Hotelper night from £54Estimated price based on searches in the last month
Merchant City Inn Hotelper night from £48(price for Tue, 04 Feb)
Holiday Inn Express GLASGOW - CITY CTR THEATRELAND Hotelper night from £57(price for Thu, 30 Jan)
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subset: commoncrawl


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Schools on lockdown; Wixom police release sketch of suspected shooter WITH VIDEO
Wixom police released a sketch of a suspect in recent shootings that have residents in southwest Oakland County and surrounding counties on edge, as the number of shootings has increased.
On edge today, schools in the area of the prior shootings are on lockdown today, with children and teenagers not being allowed outside to play, the Associated Press reported today. A task force comprised of investigators from numerous local, state and federal agencies is working on the case.
At a Friday press conference, Oakland County Sheriff Michael Bouchard confirmed 15 shootings in three days last week -- without injury -- at the hands of a suspected shooter. Bouchard said there were similar incidences of random shootings in Wixom and Lyon Township, as well as Livingston and Ingham counties. Additional shootings reported by other agencies have pushed the number of instances to 22, including incidents along the I-96 corridor, according to recent reports.
Here is a list of the agencies and the shooting in their jurisdiction:
Wixom Police Dept.: 10 incidents
Ingham County Sheriff's Office: 7 incidents
Oakland County Sheriff's Office: 2 incidents
Livingston County Sheriff's Office: 1 incident
Perry Police Dept.: 1 incident
Shiawassee County Sheriff's Office: 1 incident
Still, no one has been hit or injured, though one woman said her rear windown was shattered when struck by a bullet.
Besides the six agencies listed above, the task force also has detectives from Walled Lake police, Michigan State police, Michigan State University police, Michigan's Intelligence Operation Center, and the U.S. Bureau of Alcohol, Tobacco, Firearms and Explosives.
The image in the police sketch was created by a forensics specialist based on information described by an Ingham County shooting victim. The witness was also able to describe the suspected shooter's vehicle in the Oct. 18 incident. The witness said the suspected vehicle resembles a 1998 Oldsmobile Alero or Toyota Camry.
Watch a report on the Wixom police sketch of the suspect during today's News at Noon.
Vehicles reported in calls to police have previously ranged from a Ford Mustang to a Chevrolet Cavalier, both dark in color.
The Assoicated Press reports tipsters have told police the gunman appears to be a white man in his 30s.
Five different vehicles were shot at Oct. 18 as they drove north on Wixom Road from south of Pontiac Trail to an area near Charms Road. Recovered bullet slugs were being examined by the Oakland County Sheriff's Office crime lab late last week.
A multi-jurisdictional task force has been assembled in conjunction with law enforcement in surrounding counties in an effort to locate the suspect.
Another possible shooting was being investigated late last week to determine whether it was related to the Wixom shooting suspect.
Bouchard indicated Friday the incidents appear to be occurring along the I-96 corridor. The incidents are all thought to be related due to their frequency and similarity.
Three residents were believed to have been shot at in the first report in this spree, Oct. 16. No new incidents believed to be linked to the suspected shooter have been reported since Oct. 18. The number increased as additional agencies reported incidents in their areas.
Wixom police said multiple tips have been reported and are being investigated.
Anyone with information is asked to call 1-800-SPEAK-UP or contact the Wixom Police Department Detective Bureau at (248) 624-6114.
(Staff writers Paul Kampe and John Turk contributed to this report)


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- Description
DetailsAttractive and versatile, the FLARE MEDIUM DUFFEL adds an eye-catching flash to all your carrying needs. The shiny, hexagon-patterned, 600-denier polyester bag with PVC coating is loaded with storage options. With a spacious main compartment, a removable front pocket, a zippered inside pocket, external mesh pockets and even a shoe pocket, this gear bag handles it all. A handle wrapper and adjustable/detachable shoulder strap make transport just as snappy. Perfect as a lacrosse gear bag or a cheer duffle bag. Dimensions: 21"W x 12"H x 8"D Style 1740.
Perfect for:
Cross Country
Lacrosse/Field Hockey
- Reviews
what are the dimensions of this bag?Dimensions: 21"W x 12"H x 8"DDate published: 2019-10-22
Looks like a good bag, the right size, too. How durable is it for the weather? I've found myself out in a sudden cloudburst with an Eddie Bauer bag that just won't repel water. Can you help? Thanks.This bag is a Shiny hexagon patterned polyester with PVC coating and 600-denier polyester with PVC coating. It should repel water but is not water resistant. Hope this helps!Date published: 2016-09-19


text: On Wed, 20 May 2009 17:49:47 +0530 Kalyan Chakravarthy <kalyanchakravarthy at hyit.com> wrote: > Hi > Now i can able to get the form details in to python code, > > can any one tell me the format to send form values to one Emil > id ... for this I required SMTP set up? You can use email and smtplib modules for that along with any SMTP relay you have access to, even if it requires authentication - smtplib has support for that. Following example doesn't uses authentication for SMTP so you might want to add it or you can indeed set up some SMTP on local machine (there are really simple ones like ssmtp or msmtp, that can relay mail to auth-enabled host). import smtplib from email.MIMEMultipart import MIMEMultipart from email.MIMEBase import MIMEBase from email.MIMEText import MIMEText from email.Utils import COMMASPACE, formatdate from email import Encoders import os, collections def send(to, subj, body, files=[], from=None, relay='localhost'): if not isinstance(to, collections.Iterable): to = (to,) msg = MIMEMultipart() msg['From'] = from msg['To'] = COMMASPACE.join(to) msg['Date'] = formatdate(localtime=True) msg['Subject'] = subj msg.attach( MIMEText(body) ) for file in files: part = MIMEBase('application', "octet-stream") part.set_payload( open(file,"rb").read() ) Encoders.encode_base64(part) part.add_header('Content-Disposition', 'attachment; filename="%s"'% os.path.basename(file)) msg.attach(part) smtp = smtplib.SMTP(relay) smtp.sendmail(from, to, msg.as_string() ) smtp.close() -- Mike Kazantsev // fraggod.net -------------- next part -------------- A non-text attachment was scrubbed... Name: signature.asc Type: application/pgp-signature Size: 205 bytes Desc: not available URL: <http://mail.python.org/pipermail/python-list/attachments/20090521/21ce1c61/attachment-0001.sig>


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Spectrum Laboratories
Company Profile
Since 1970, Spectrum Laboratories has developed and manufactured innovative products for bioseparation and cell line management. Spectrum products are used for the filtration, isolation, purification and concentration of pharmaceuticals, diagnostics, food, beverages and industrial fluids.
Spectrum pioneered the development of dialysis membranes and accessories, disposable hollow fiber filtration modules and systems, supported polymeric liquid membranes and preparative low-pressure liquid chromatography products.
Our membranes and membrane modules are used for macrofiltration, microfiltration, ultrafiltration, diafiltration, dialysis and extraction. With over 2,000 products, ranging from small disposable membrane modules to high volume systems, you can be certain we have a product for your application.
We continue to make significant investments in R&D to develop and provide new products and advance separation technology as a whole. Spectrum's team of membrane scientists, engineers, technical experts and quality control personnel is always available to support your separation application. Our dedicated OEM group is available to work with our customers on special projects.
Global Offices
Spectrum has grown to become a global company with corporate headquarters in Rancho Dominguez, California and manufacturing facilities in Rancho Dominguez, CA; Houston, TX and Dallas, TX. We have a European sales office in Breda, Netherlands and an Asian sales office in Otsu-city, Shiga, Japan. Spectrum also supplies products world-wide through a network of international distributors.
Belenos & Spectrum
Belenos HandelsgmbH has become an offcial distributor of Spectrum Laboratories Inc. in 2013. We offer the complete product assortment of Spectrum Labs.
Link: Spectrum Laboratories


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Harvey Paul Green Blazer
A new and fun twist to a blazer by Harvey Paul is a key piece for your wardrobe this season. Harvey Paul blazers are well cut and tailored to perfection. These structured blazers will add a sense of power to all your outfits.The fabric and attention to detail with piping and linings are truly divine. Our Model is wearing this blazer with Toxic Jeans and a frill top by Harvey Paul
This blazer is true to size
Size UK 8
Size UK 10
Size UK 12
Size UK 14
Size UK 16
Style Blazer
Colour Green
Fabric 80% Polyester 20% Viscose
Care Instruction Dry Clean


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There is no better way to see everything Catania ( Sicily ) has to offer than by getting behind the wheel of your Avis rental car. Stop spending your vacation waiting on the bus, or wasting money here and there with ride-shares or taxis. When you have access to your own ride, you can drive wherever you want to go, when you want. Make your next getaway to Italy more enjoyable with an Avis rental car.
CarRentals.com takes care of all the speed bumps
With everything to do in and around Catania ( Sicily ), you'll want to take in more than the block your hotel is on during your trip. Whether you are dying to have dinner at the chophouse that has received great reviews across town or check out some of the best local favorites, you'll want your own auto to see as much as you can during your getaway. Whatever you have planned in Catania ( Sicily ), if you want to get the most out of your time in the city, having access to your own car is key.
CarRentals.com works with the most dependable car rental companies. The first car rental business located in an airport, Avis has over 70 years of providing rental cars to travelers from all over. With over five-thousand locations globally and a diverse fleet of automobiles, Avis is sure to provide you a great experience from start to finish.
What you need to know about car rentals
How do I get a Catania ( Sicily ) Avis rental car at a great rate?
We try to get you the lowest price, no matter when you reserve your car. However, getting your car ahead of your visit can help keep spending low. Be sure to keep the car under one driver's name and read the mileage policy to avoid any surprise fees.
Do I need to bring anything special when I pick up my car in Catania ( Sicily )?
You will need to present your driver's permit and a credit card in your name.
How old do I have to be to rent a car in Catania ( Sicily )?
Avis's minimum age to rent a car in Catania ( Sicily ) is 21. Take time to read through Avis's policies, as there may be added fees if you are under 25 or for higher category vehicles especially.
Is there a particular vehicle I should get for my trip to Catania ( Sicily )?
That depends on your needs and what activities you want to do in Catania ( Sicily ). Economy or compact automobiles are great for short drives and are easier to park. If you are traveling with a bigger group, then a SUV or mid-size vehicle is going to have more room and offer a more comfortable ride. Those looking for a touch of luxury on their Catania ( Sicily ) trip can choose the premium category to get a car like a Mercedes C-Class or Cadillac XTS or similar.
Does Italy require car insurance?
You are required to have insurance before you rent from Avis in Italy. Many major credit cards (Discover, American Express, Visa and MasterCard) typically offer coverage. However, many of them have restrictions, such as not covering larger vehicles, like trucks or SUVs. Make sure to call and find out exactly what your credit card will cover and how much before you head to Catania ( Sicily ). Otherwise, as a U.S. citizen, you can add on Collision Damage Coverage with CarRentals.com at checkout.
Does Avis require a deposit at the time of booking my rental car?
Avis does require a deposit when you reserve your rental car. Avis will block the deposit on your credit once you book your rental for your trip to Catania ( Sicily ). Please be aware that the deposit can vary greatly depending on the make and model of the rental.
What is the fuel policy on my Avis car rental?
At CarRentals.com, we suggest a full to full policy. You pick up your Avis rental with a full tank, and you will want to refuel up to the amount you picked the car up with. If you want to keep your expenses lower, it is best to find a filling station before you bring it back to Avis.
Why should I get unlimited miles?
Catania ( Sicily ) definitely has its charms, but you may want to hit the road again after you've checked off all the activities here.
Does Avis offer one-way rentals in Catania ( Sicily )?
Avis typically offers one-way rentals. You may find it easier to return your rental at another Avis. Be aware there may be an additional fee when you choose one-way.
Reserve your ride today!
With so much to do and see in Catania ( Sicily ), having the keys to your own set of wheels lets you explore at your own pace. When you are ready to discover more of Italy, you can leave wherever you like, without waiting for your ride to pick you up or figuring out a bus schedule.
Before your next family vacation, book your Avis Catania ( Sicily ) car rental and visit all the must-do activities. Book with CarRentals.com and drive the streets in Catania ( Sicily ), Italy.


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Health Talk
Karen CollinsPress Registration
AICR's Health Talk is a column by Karen Collins, MS, RDN, CDN, FAND, discussing the latest hot topics in the field of diet, nutrition and cancer.
Columns are now found on our blog monthly. For permission to reuse in media outlets please contact firstname.lastname@example.com.
Latest Health Talk articles
- July 25, 2016I hear that pulses like black beans are super-nutritious. But aren't they fattening?
- July 18, 2016Can something as simple as removing my candy dish at work really make a difference for healthy eating?
- July 11, 2016I've heard that lettuce varieties have different nutritional value and some aren't worth eating. Is that true?
- June 27, 2016Is lemonade a lower-calorie alternative to regular soda?
- June 20, 2016Does exercise lower cancer risk regardless of my weight?
- June 13, 2016Which is healthier, a tortilla or a slice of bread?
- June 6, 2016What's the difference between sherbet and sorbet?
- May 30, 2016Does olive oil reduce risk of breast cancer?
- May 23, 2016What are Quick and Healthy Breakfasts I Can Eat at my Desk?
- May 16, 2016I keep hearing about planks for strong abs. What's a plank?
- May 9, 2016Can Chewing Gum Really Help You Lose Weight?
- May 2, 2016Do I need more water when I drink coffee so I don't get dehydrated?
- April 25, 2016Getting Enough Fiber without Supplements
- April 18, 2016Will An Exercise Journal Help Me Be More Active?
- April 11, 2016Sugar-Free Cakes and Cookies and Weight Loss
- April 4, 2016Does a lactose-free diet play a role in reducing cancer risk?
- March 28, 2016How do lentils compare nutritionally to other dried beans?
- March 21, 2016The Importance of Strength Training for Older Adults
- March 14, 2016The Scoop on Coffee Health Claims
- March 7, 2016What is a low glycemic index diet and will it help me lose weight?
- February 29, 2016Pomegranates and Prostate Cancer
- February 22, 2016Are Dates and Dried Figs too Loaded with Sugar to be Healthy?
- February 15, 2016Is steel-cut oatmeal more nutritious than other kinds of oatmeal?
- February 8, 2016How to Follow a Plant-Based Diet for Cancer Prevention
- February 1, 2016Cutting Calories to Lose Weight
|Items 1 - 25 of 185
Published on 12/31/2099


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For those that have never been before Inflata Nation is an indoor inflatable arena so is perfect for lots of bouncing fun.
Little J couldn't wait to get bouncing as soon as we walked through the door. Upon arrival you need to complete a waiver form (if you haven't already done it when you booked online). You are given a coloured wristband to show staff that you have bought and paid for a one hour time slot. If you book two hours you will be given a second different coloured wristband. Once checked in you can remove your shoes and place them in a locker and then head for a safety brief.
As soon as that is complete you head to the inflatable arena ready for your session. There are so many features to choose from little J didn't know where to start.
The new arena has lots of super slides to choose from
Two lane slides with a jaw dropping 7m near vertical drop. This was little J's favourite thing. He went on it 25 times. He just wanted to go round and round and round again. He is such a daredevil and the look of excitement as he slid down with his arms crossed on his chest, made me giggle.
Next to the vertical drop slides are dual bumpy slides. Little J didn't quite fancy these but John had a turn and almost flipped upside down.
The incredible tipping slide looked fun so I encouraged John and little J to go on it. It will definitely test your balance and skills as the slide inflates and starts tipping you down.
Inflata Free fall is a new free fall activity for all thrill seekers. Take a jump off the 6m platform. You'll be wearing a harness and clipped to a free fall device to help you land safely.
The new ball pit was another favourite of little J's.
There is also and Improved interactive obstacle course for trying out those challenging ninja style moves. Both John and little J tried this out and had lots of fun doing so.
Inflata Duel, the popular and hilarious gladiator podium is back however we were told it was reserved for a party only which was a shame. Little J was desperate to have a turn.
As well as the arena there is a downstairs cafe, party and viewing area plus an upstairs seating/viewing area too.
Inflata Nation.
We really enjoyed our session and I would definitely recommend choosing a two hour bounce. It will give you time to take a break in between and have a drink as it does get hot in there.


text: gforce Posted September 18, 2018 I'm wondering if she mentioned she was going to do that name call out to the show's producers or if it was a surprise to them, too. If it was unexpected, that's the kind of stuff that gets your contract not renewed. And maybe that was her intention. If so, it strikes me as rather unprofessional. Share this post Link to post Share on other sites


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The Montgomery Village Board has approved plans by Aurora University to build an athletic complex in the village.
The facility will be built at the old Wolf Run Golf Course at 1700 W. Jericho Road.
The proposed complex would include locker rooms and training facilities; a 3.5-acre baseball stadium; a 1.3-acre softball stadium; a 4.7-acre track and field stadium; a 1.6-acre soccer stadium; and a 1.6-acre multipurpose field. The complex would have more than 300 parking spaces.
The attorney for Aurora University working on the project, Bruce Goldsmith with the Dykema Law Firm, said the university has great hopes for the complex and said in the future additional land adjacent to the current site may be included in the project.
There is no specific timetable at the moment for when the project will begin.
Judy Pochel is a freelance writer for The Beacon-News


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OPELIKA, AL (WTVM) - If you're looking for a fun, mind-blowing event, the circus has come to one East Alabama town.
The Cole Bros. raised the world's largest circus tent Wednesday morning at the USA Town Center in Opelika.
Performances were held Wednesday afternoon and evening. If you missed the excitement Wednesday there's still time to take the family.
The Cole Bros. Circus continues through Thursday with shows at 4:30 and 7:30 p.m. Central.
You can find free admission tickets for children and $5 adult tickets at local merchant locations or on the circus website colebroscircus.com.
According to its website, the Cole Bros. Circus remains the only circus to have survived a century, still appearing much as it did more than 100 years ago under the Big Top.
Copyright WTVM 2015. All rights reserved.


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Dr. Anita Sethi is one of the best Opthalmologist in Gurgaon with an experience of over 22 years in his field. Dr. Anita Sethi is an experienced eye surgeon currently working as Director and Head of Department, Ophthalmology at Fortis Memorial Research Institute, Gurgaon. She is also the Senior Ophthalmology Consultant at NOVA Specialty Hospitals, Delhi. Dr. Anita Sethi has vast experience in the field of eye surgery and believes in delivering comprehensive eye care to the patients. She is proficient in Lasik Surgery, Phaco Eye Surgery, Refractive surgery, Ptosis & other Oculoplastic Surgery, Cornea treatment and Cataract treatment. Dr. Anita Sethi is known among the best ophthalmologists in India.
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With over 22 years Of Experience, trained at the prestigious Dr. R P Centre for Ophthalmic Sciences, Delhi, Dr. Anita Sethi is proficient in anterior segment surgery including Phacoemulsification surgery & LASIK and also has a keen interest in Orbital and Oculoplastic surgery. An experienced surgeon, she has chaired numerous sessions and conducted workshops at a national level in the various aspects of Eyelid and Orbital surgery. Dr. Anita Sethi has participated as faculty in many conferences in the Phacoemulsification and LASIK sessions. Dr. Sethi is responsible for establishing the Ophthalmic services at Artemis health institute, Gurgaon & Nova Specialty Hospitals, New Delhi.
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Volunteer Appreciation Party
November 6, 2019 @ 6:00 pm - 8:00 pmFREE
Have you volunteered for TART Trails? Donated time to work on the trails or on behalf of TART in any way, shape or form? Then please join us for our annual Volunteer Appreciation Party. It's a great opportunity to meet and mingle with other volunteers and learn more about our volunteer and Ambassador programs. This is also a chance for us to shower you with gratitude and raise a glass to celebrate all that we have accomplished together over the past year. Please plan to attend if you can as it is always a mighty fine time with some of the best company around. Dinner and your first drink are on TART!
What: TART Trails Volunteer Appreciation Party
Where: The Jolly Pumpkin, 13512 Peninsula Dr., TC, MI 49686
Date: Wednesday, November 6
Time: 6 – 8 pm
Please feel free to forward this invite to fellow volunteers. Space is limited, RSVP no later than Nov 1. RSVP to Caitlin Early at firstname.lastname@example.com or call 231.941.4300.


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Kristopher Mendoza, DDS
I still remember THAT day of dental school. In the midst of our class on anxiety and pain control, our didactic course turned into an experiment on our fellow classmates. Unlike the injection workshop, affectionately known as "stab lab," I looked forward to this one. I placed the nasal mask over my nose and proceeded to take a few deep breaths. My friend continued to raise the concentration . . . 25%, 40%, 50% . . . and then 60%. There it was: euphoria and weightlessness. Sadly, after a minute, the nitrous oxide was turned off. The oxygen was turned to 100%, ending that rare moment of bliss found within the chaos of dental school.
That day, I thought that nitrous oxide was amazing. But it turned out it wasn't for everyone. On the other side of the classroom were two of my classmates. Let's just say one of my classmates didn't experience the same feeling I did. Instead of euphoric bliss, she experienced feelings of uneasiness followed by sweating and feelings of losing control. Instead of sinking into the chair, she tried to jump out of it. Feeling like she was in a sauna, she shed extra layers of clothes. For her, "laughing gas" wasn't a laughing matter.
Nitrous oxide may be considered ubiquitous in dentistry, but in reality, many providers avoid this potentially valuable service for patients. To help all of us understand this powerful tool better, I've prepared a quick refresher course on nitrous oxide delivery.
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General information
Nitrous oxide (N2O) is the most common inhalation anesthetic used in dentistry, with its first use dating back to Horace Wells in 1844.1 For decades, it has been used regularly by dentists as an effective anxiolytic and mild analgesic. It is a nonpotent, inhalational anesthetic that is colorless, odorless, and nonirritating to the tissue. While it is affectionately known as laughing gas, it is not suitable for all patients. Care should be taken when administering N2O in the dental setting. A detailed history and physical should be reviewed to prevent adverse events.
Physiologic properties
N2O has a rapid onset of action due to its low blood-gas solubility. It is transported in the blood as a free gas, not combining with hemoglobin in the blood. It does not undergo biotransformation in the body and is eliminated by expiration.
Minimum alveolar concentration
Minimum alveolar concentration (MAC) is defined as the percentage of an anesthetic gas that is needed to prevent a response from a surgical stimulus in 50% of patients. N2O has a MAC of 104% and therefore a low potency. Its use at sub-MAC doses is effective for anxiolysis and mild analgesia. While every patient responds differently to N2O, factors that increase MAC (i.e., decrease effectiveness) include fever, CNS stimulants (e.g., cocaine), decreasing age, and chronic alcoholism.2 Factors that decrease MAC (i.e., increase effectiveness) include acute CNS depressants (e.g., alcohol), increasing age, severe hypercapnia, severe hypoxemia, and anemia.2
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Systemic effects
N2O has minimal cardiovascular and respiratory effects—unless combined with opioids or other sedatives. There is increased respiratory response due to sympathetic stimulation, which can be offset by opioid use. Concentrations below 50% MAC have minimal effect on hypercapnic response (i.e., response to carbon dioxide). However, concentrations as little as 10% MAC produce a 50%–70% decrease in ventilatory hypoxemic response (i.e., response to oxygen).2 This may interfere with the ability of patients with COPD to breathe, since they heavily rely on their hypoxemic response for ventilation.
N2O is commonly used for anxious or fearful patients, especially pediatric populations. It may be used to alleviate fear or pain of an injection. In a small study, N2O allowed patients with a hypersensitive gag reflex to tolerate placement and holding of a digital sensor as well.3
Patients with conditions involving enclosed cavities may experience significant problems. These conditions include COPD, cystic fibrosis, pneumothorax, intraocular air bubbles, middle ear effusion, air embolism, and bowel obstruction.1 This is due to the fact that N2O diffuses into air spaces quicker than nitrogen can enter the bloodstream, therefore increasing the pressure in those enclosed spaces. Pregnant patients, especially those in the first trimester, should not receive N2O because it has been associated with infertility. Furthermore, patients unable to breathe through the nose (i.e., nasal obstruction) or those unable to sit with a nasal mask are not suitable candidates for N2O.
Side effects and toxicity
Although rare, side effects may include postoperative nausea and vomiting (PONV), dizziness, headache, tingling, euphoria, and diffusion hypoxia.2 Risk for these effects increases as concentration and duration of N2O is increased. Preoperative fasting is an independent risk factor for PONV; therefore, having patients drink or eat something light two hours before administration may be advantageous.4
Caution should be used when titrating N2O to avoid deep sedation, which may lead to other serious adverse reactions such as laryngospasm, desaturation, and apnea.4
Long-term administration/exposure to N2O can lead to inactivation of vitamin B12, which can cause hematological irregularities (e.g., increased homocysteine levels, megaloblastic anemia), bone marrow suppression, central nervous system toxicity, optic nerve injury, thrombosis, and infertility.5 Initial symptoms may include paresthesia or numbness in the limbs that advances to the trunk. Treatment includes injections or supplements of vitamin B12.4 While these levels of toxicity are uncommon, precautions such as an adequate scavenging system, well-ventilated rooms, and administering 100% oxygen for 3–5 minutes at the end of the case should be performed.5
N2O is most commonly stored under 750 psi as a vapor overlying a liquid in a blue color-coded tank. The standard E cylinder for N2O contains 1,600 L of nitrous gas. Unlike oxygen (O2), the pressure gauge will read at 750 psi until 25% of the gas is left (400 L of N2O) in the cylinder. The only reliable way to determine the amount of N2O left in the tank before the 25% threshold is reached is by weighing the cylinder and comparing it to its full weight.
According to the National Institute for Occupational Safety and Health, N2O exposure should be limited to 25 ppm in order to minimize any potential effects from long-term exposure.6 N2O should always be administered with a scavenging system and a tight nose seal in place in order to reduce environmental exposure. According to one study, delivering N2O in an open clinic also reduced levels in the environment.6 Recent studies indicate that N2O may be administered via a nasal high-flow system,7 which may improve patient comfort, although there is no data about potentially increased risk of environmental exposure.
N2O delivery systems are usually equipped with a fail-safe feature, which prevents N2O delivery without O2, and a flow-safe feature, which prevents less than 30% O2 delivery.5 The concentration of N2O delivered is typically between 30% and 70%. However, the concentration reaching the alveoli is often reduced. This is due to various factors, including equipment leakage, mouth breathing, poorly fitting masks, and physiological dead space.2
N2O concentration should be increased by 10%–25% every 1–2 minutes to avoid oversedation or potential adverse events. An easy way to deliver N2O is by starting with 6 L/min O2, adding 1 L/min of N2O, and reducing 1 L/min of O2 every 1–2 minutes until the optimal effect is reached. Maintain this concentration of N2O, reminding the patient to breathe through the nose so that the N2O continues to achieve maximum effect.
It is critical to continuously monitor patients' respiration and consciousness to prevent oversedation and other unwanted effects. In order to avoid possible diffusion hypoxia and reduce unnecessary N2O exposure to the operatory, administer 100% O2 for 3–5 minutes at the end of the case. Ensure that the patient returns to preoperative levels of function and cognition before discharge.
Recent studies suggest that patients may develop a tolerance to N2O after multiple exposures,8 leading to less analgesia and anxiolysis with the same concentration of N2O. It may be prudent to ensure that the patient is adequately sedated before starting any dental work for the anxious patient.
With a long history of safety and efficacy, nitrous oxide can be an incredible service to alleviate the pain and anxiety of our patients. But even with its long track record, adverse effects are still possible. Therefore, a proper preoperative assessment is crucial. Regardless of the procedure, always remember, it our responsibility as doctors to ensure that we are keeping our patients' best interest and safety in mind.
1. Huang C, Johnson N. Nitrous oxide, from the operating room to the emergency department. Cur Emerg Hosp Med Rep. 2016;4(1):11-18.
2. Becker D, Rosenberg M. Nitrous oxide and the inhalation anesthetics. Anesth Prog. 2008;55(4):124-131.
3. De Veaux C, Montagnese T, Heima M, Aminoshariae A, Mickel A. The effect of various concentrations of nitrous oxide and oxygen on the hypersensitive gag reflex. Anesth Prog. 2016;63(4):181-184.
4. Chi S. Complications caused by nitrous oxide in dental sedation. J Dent Anesth Pain Med. 2018;18(2):71-78.
5. Guideline on Use of Nitrous Oxide for Pediatric Dental Patients. American Academy of Pediatric Dentistry website. http://www.aapd.org/media/Policies_Guidelines/G_Nitrous.pdf. Accessed August 17, 2018.
6. Kugel G, Norris L, Zive M. Nitrous oxide and occupational exposure: it's time to stop laughing. Anesth Prog. 1989;36(6):252-257.
7. Sanuki T, Mishima G, Kiriishi K, et al. Nitrous oxide inhalation sedation through a nasal high-flow system: the possibility of a new technique in dental sedation. Anesth Prog. 2017;64(3):175-177.
8. Ramsay D, Leroux B, Rothen M, Prall C, Fiset L, Woods S. Nitrous oxide analgesia in humans: acute and chronic tolerance. Pain. 2005;114(1):19-28.
Kristopher Mendoza, DDS, received his dental anesthesiology degree from the University of California, Los Angeles, in 2018. Prior to residency, Kris graduated from the UCLA School of Dentistry. He served as the national president of the American Student Dental Association from 2014 to 2015. He practices at CarePoint Anesthesia Group in Colorado.


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Thursday, May 31, 2018 by Mose Buchele
New data show lead in drinking water at five more Austin schools
Lead has been found in the drinking water of five Austin public schools, new data obtained by Environment Texas from the Austin Independent School District shows. It's the second time in the past year the toxic metal has been discovered in AISD schools and facilities.
The tests revealed lead at levels considered especially unsafe by the American Academy of Pediatrics in certain taps at Boone and Patton elementary schools, Bailey and Covington middle schools, and Lanier High School. Environment Texas obtained the data through a public information request.
Exposure to lead in children can cause irreversible cognitive and behavioral problems. After the drinking water crisis in Flint, Michigan, pointed a spotlight on lead contamination, AISD decided to test water.
Luke Metzger, the executive director of Environment Austin, said that while the latest results are troubling, it's good that AISD is doing the tests.
"Unfortunately, there is no state or federal law to require school districts to do anything on this, so it really requires individual school districts to take action," he said.
AISD would not provide an interview for this story. It did forward KUT a letter it sent to parents and guardians of students at the affected schools.
"We are in the process of replacing or installing a filter" on any water fountain where more than the lowest levels of lead were detected, the school district wrote.
"At this time, all the follow-up testing has shown the levels of lead at the lowest level of 0.001," it continued.
Last September, lead was found in the water of nine AISD schools and facilities. The district also installed filters and replaced water fountains to get rid of the contamination after that test, while seeming to minimize the threat it posed.
Pointing out that more lead can be found in some bottled water than in the affected taps, the district said at the time that the results "were below levels that would require the (Environmental Protection Agency) to take action."
"This is based on EPA standards for municipalities that say that action is indicated if 10 percent of tap water samples exceed the level of 15 parts per billion," the school district said in an announcement.
Metzger says AISD is one of many Texas school districts struggling to keep lead out of its water supply.
"We've been collecting testing data from schools around Texas," he said. "Right now we estimate about 800 schools around the state have tested positive for lead."
This story was produced as part of the Austin Monitor's reporting partnership with KUT. Photo by Jorge Sanhueza-Lyon/KUT.
The Austin Monitor's work is made possible by donations from the community. Though our reporting covers donors from time to time, we are careful to keep business and editorial efforts separate while maintaining transparency. A complete list of donors is available here, and our code of ethics is explained here.
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Key Players & Topics In This Article
AISD: Austin's largest school district, AISD is the Austin Independent School District.