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Clovis Oncology, Inc.CLVS incurred an adjusted loss of $1.71 per share in the third quarter of 2018, wider than the Zacks Consensus Estimate of a loss of $1.60 and the year-ago loss of $1.24 per share.
Net revenues, entirely from Clovis' only marketed drug, Rubraca, were approximately $22.8 million in the quarter, down 4.2% sequentially, due to challenges in adoption in earlier-line setting. Revenues missed the Zacks Consensus Estimate of $30.12 million. The company had recorded total revenues of $16.8 million entirely from Rubraca sales in the year-ago quarter.
Clovis stated that Rubraca is failing to capture significant share in the second-line maintenance ovarian cancer market as it has to compete with PARP inhibitors as well as other approved therapies. This is hurting sales of Rubraca. The company expects Rubraca sales to be similar or slightly higher than $22.8 million in the fourth quarter. The Zacks Consensus Estimate for the fourth quarter is pegged at $40.24 million.
Shares of the company declined almost 19.7% in pre-market trading , on lower-than-expected sales of Rubraca and the disappointing guidance. Moreover, Clovis has underperformed the industry in the past six months. The stock has lost 63.2% compared with the industry's decline of 8.7%.
Operating Expenses & Cash Details
During the third quarter, research & development expenses increased 64.3% year over year to $63.9 million primarily due to increased expenses for clinical studies on Rubraca. Selling, general and administrative (SG&A) expenses escalated 21.4% year over year to $42.5 million, reflecting increased activities to support commercialization of Rubraca in the United States as well as Europe.
Cash used in operating activities in the quarter was $72.5 million, higher than $45.8 million in the year-ago quarter.
Clovis ended the quarter with $604.4 million of cash equivalents and available-for-sale securities compared with $682.2 million as of Jun 30, 2018.
Update on Rubraca
In July 2018, the European Medicines Agency ("EMA") accepted the regulatory application for the label expansion of Rubraca to include maintenance treatment in recurrent ovarian cancer. A European approval for maintenance setting is expected in early 2019. The drug was launched for a similar indication in the United States in April. The EMA approved the drug for ovarian cancer patients with BRCA-mutation in third- or later-line setting in May.
The company is actively working on expanding the label of Rubraca in and beyond ovarian cancer. The company is evaluating Rubraca as monotherapy or in combination with immunotherapies - Bristol-Myers' BMY Opdivo or Merck's MRK Tecentriq - in multiple clinical studies in additional indications including first-line ovarian cancer, prostate and breast cancer. In August, a phase III study was initiated to evaluate Rubraca - Opdivo combo in advanced ovarian cancer.
In October, the company presented encouraging initial data from phase II TRITON2 study evaluating Rubraca in metastatic castration resistant prostate cancer.
Apart from Rubraca, Clovis is also developing lucitanib for treating breast and lung cancer. Clovis now owns global (excluding China) development rights for lucitanib, as its partner returned the ex-U.S. rights during the quarter.
Our Take
The adoption of Rubraca in manitenance setting in the United States was dismal. The company is facing challenges for the expansion in early line of therapy and the PARP inhibitor market has stagnated. The company may also face similar challenges in Europe if Rubraca gets approval in maintenance setting. Rubraca competes with Tesaro, Inc.'s TSRO Zejula and AstraZeneca's Lynparza in its approved indications.
Operating expenses are expected to rise in 2018 as the company will incur higher investments to support Rubraca's launch in Europe and expanded indication in the United States.
Clovis Oncology, Inc. Price, Consensus and EPS Surprise
Clovis Oncology, Inc. Price, Consensus and EPS Surprise | Clovis Oncology, Inc. Quote
Zacks Rank
Clovis currently has a Zacks Rank #4 (Sell).
You can see the complete list of today's Zacks #1 Rank (Strong Buy) stocks here .
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To read this article on Zacks.com click here.
The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.
The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.


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Nurse – Nursing Homes – Go Nurse are a London temporary nursing agency who are looking for super nurses to join their team.
Full time nurses, part time nurses, RGN nurses, RMN nurses and occasional shift nurses are welcome to apply and have an interview local to you!
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Applications are welcome from RGN or RMN nurses who are registered with the NMC with relevant UK experience
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However…. Even if you have zero nursing home experience in any of the above you may still be considered, so long as you have a positive attitude and are fantastic with clients. (*Nursing qualification and registration with NMC are essential though)
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Ihr Warenkorb ist leer.
Ihr Merkzettel ist leer.
von: G. Willow Wilson, Adrian Alphona, Takeshi Miyazawa, Elmo Bondoc
Mehr Artikel von: Marvel Comics
Kamala Khan may not be allowed to go to the school Valentine's Day dance, but Ms. Marvel will crash it - in an attempt to capture Asgard's most annoying trickster, Loki! And when a mysterious, and really cute, family friend comes to town, Ms. Marvel must deal with...a crush! Then, it's the moment you demanded as Ms. Marvel meets her idol: Carol Danvers and Kamala Khan battle side-by-side!
The Marvel Universe's last days have arrived, but Ms. Marvel has no time for silly things like Armageddon - she's got to rescue her brother and keep her city from falling into chaos. When the world is about to end, do you still keep fighting? Kamala knows the answer. Let's do this, Jersey City.
MS. MARVEL (2014) #12-19, S.H.I.E.L.D. (2014) #2 and material from AMAZING SPIDER-MAN (2014) #7-8
Format: Album (Hardcover)
Sprache: englisch
schwarzweiß/Farbe: Farbe
Diesen Artikel haben wir am 06.04.2016 in unseren Katalog aufgenommen.


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1980 · Beijing
Beijing: Zhongguo she hui ke xue chu ban she, 1980. Six issues of the literary journal, numbers 2-6 for 1980 and no. 3 for 1981, the last one with old tape repair to spine. Pages toned, otherwise very good. (Inventory #: 230291)
by Foote, ShelbyNew York : Random House , 1974
by Twain, Mark, illustrations by E. W. KembleShelton, CT : The First Edition Library , 1990
You can be confident that when you make a purchase through ABAA.org, the item is sold by an ABAA member in full compliance with our Code of Ethics. Our sellers guarantee your order will be shipped promptly and that all items are as described. Buy with confidence through ABAA.org.


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Famine looms as desert locusts head to bread basket counties
Thursday, January 16th, 2020
- Locusts are part of a large group of insects commonly known as grasshoppers, but which have big hind legs for jumping and also differ from grasshoppers in that they have the ability to change their behaviour and habits and can migrate over large distances.
- A desert locust lives for three to five months although this varies and depends on weather and ecological conditions.
- The life cycle comprises three stages: egg, hopper, and adult. Eggs hatch in about two weeks (the range is 10-65 days). Hoppers develop in five to six stages over a period of about 30-40 days, and adults mature in about three weeks to nine months but more frequently from two to four months.
Bernard Gitau and Nicholas Waitathu
The Food and Agriculture Organisation (FAO) has warned that the country is facing a serious food crisis as the desert locusts begin to spread to counties in the Mt Kenya and Rift Valley regions.
Yesterday, the new Agriculture Cabinet Secretary Peter Munya said Treasury had allocated Sh230 million towards the control of the locusts that have devastated many parts of the north-eastern region.
Speaking to the media at Kilimo House soon after taking over from Mwangi Kiunjuri who was sacked on Tuesday, Munya said the money will be used to hire three more spray aircrafts to fight locusts' swarms in Garissa, Marsabit and Mandera counties.
This will be an addition to two aircrafts from the Desert Locust Control Organisation of Eastern Africa that have been undertaking aerial control of the insects.
He said the Ministry had also received four aircrafts from Kenya Wildlife Services, Kenya Pipeline and Kenya Forest Service.
Munya said the ministry had deployed 145 experts to the affected areas to train and mobilise county teams that will support the control efforts.
"The ministry has formed a technical team that will strategies and guide the management of desert locust with members drawn from government, private sector and academia," he said.
Moving north
FAO says the locusts are currently in 12 counties of Mandera, Wajir, Garissa, Moyale, Marsabit, Isiolo, Samburu, Meru and Laikipia and are likely to move to Baringo, Turkana and Tana River.
"More swarms are expected in these areas as some are already moving north of Mt Kenya westwards to the Rift Valley (Baringo county)," said FAO in a statement.
An invasion of the food-rich Rift Valley and Central would aggravate the food shortage, considering the Ministry of Agriculture has reported that maize production fell by 11 million bags last year.
According to the Ministry, 33 million bags of maize were harvested in 2019 down from 44 million in 2018.
The drop is attributed to the late onset of the long rains and the outbreak of diseases such as fall army worms and unpredictable weather conditions.
With a significant single swarm of the immature swarm having already attacked an area measuring 60km long by 40km wide in the northeast, FAO said a single swarm can cover 1,200 square kilometres and can contain between 40 and 80 million locusts per square kilometer.
FAO says a desert locust adult can consume roughly its own weight in fresh food, that is about two grams, per day.
A very small part of an average swarm (or about one tonne of locusts) eats the same amount of food in one day as about 10 elephants or 25 camels or 2,500 people.
The spread is expected to continue northwest to Turkana county, while others will move west along the Ethiopian border, and some could move further south to Tana River county.
"In the Horn of Africa, there has been a significant and extremely dangerous increase in swarm activity during the past week in Kenya where numerous, large immature swarms are spreading from the initial invasion areas," warned FAO.
The locusts have moved from the northeast (Mandera county) south to Wajir and Garissa, west along the Ethiopian border (Moyale and Marsabit counties) and southwest into now central areas north of Mt Kenya (Isiolo, Samburu, Meru, and most recently Laikipia counties).
Entomological Society of Kenya chairman Muo Kasina says breeding sites, preferably wet grounds, should be targeted in the control campaign.


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Trending News
Anyone surprised that once again Angelina Jolie proves that she's a phony? Details inside->?
She is one of the biggest phonies & her being an Ambassador to the U.N. is a disgrace.->
Bosnian Rape Victims Protest Angelina Jolie Movie in Letter to U.N.
Angelina Jolie is the target of more criticism over her feature directorial debut, a love story set during the Bosnian War.
The actress -- who recently cut short the film's shoot after rumors that it portrayed a relationship between a rapist and his victim sparked protests -- was called "ignorant" on Monday by a group of women who were victims of sexual violence during the 1990s war, the AFP reported.
In a letter to the United Nations refugee agency, for which Jolie is a goodwill ambassador, the Women Victims of War said its members are "deeply concerned about the movie."
"Angelina Jolie's ignorant attitude towards victims says enough about the scenario and gives us the right to continue having doubts about it," the letter read.
After rumors of the rapist love story line surfaced in October, a group of Bosnian War rape victims pressured city officials to withdraw Jolie's filming permit.
The rumors proved to be untrue, and after the country's minister of culture read the script -- about a Bosnian woman who falls in love with a Serb man -- the permit was reinstated. However, Jolie earlier this month cut the shooting schedule from 10 days to three and decided to film some of the scenes originally planned for Bosnia in Hungary instead.
At the time, Jolie said she wanted to meet with the groups that complained to clear up any misunderstanding, but no meeting ever transpired.
"We have insisted to meet Angelina Jolie since we don't want to be wrongly presented in the world ... Our voices are worthwhile and we should have got much more respect," the WVW letter read.
"Angelina made a big mistake. We feel that she did not act like a real UNHCR ambassador and we believe that she has no more credibility to remain the ambassador," the letter concluded.
12 Answers
- roseLv 79 years agoFavorite Answer
She only ever does "good" things for her own ego, because she gets a massive reaction from the press when they all say, "oooh, look at Angelina, the 21st century mother Theresa"... And she thrives on this. It makes her head inflate bigger than a hot air balloon. She's doing good in order to reep the praise and thus help her own ego (and career).
If she really wanted to do good for good's sake, she would give her money and help others privately, without anyone else knowing. She has the money and power to do that.Source(s): I never liked her anyway, she's just a fish mouthed attention seeker lmao... Immature I know haha. =D
- Login to reply the answers
- Anonymous9 years ago
In my opinion, she should never have been in that position in the first place- all she does is adopt kids, which is fine, but that doesn't mean she's doing any good. the example she's setting for those kids is horable, and like the letter said, she's not credible, and she's very ignorant and full of herself.
I'm not surprised at her latest act of idiocy, and I'm surprised she's still around enough to make these stupid choices and embarrass herself. if she was actually smart, she'd go away for a while and stop trying to be mrs. super celebrity, because I think people are sick of her. being a Goodwill Ambassador doesn't make you a good person, and it doesn't mean she should have that position still- I think her title as Ambassador needs to be re-evaluated, and probably taken away
Celebrities should not be in Government...simple as that
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- JohnLv 69 years ago
Angelina is the biggest fake, mental case out there. I have never liked her with her freakish tendancies and worry about those poor kids she adopted, although I am sure they are mostly cared for my nannies thank God. Angelina is nothing but a piece of trash that cares for no one but herself. She has no class at all as seen by her comments throughout the years about things she has no clue about. I hope she does sink with this latest slap in the face and hope she loses her ambassador status which was a joke to begin with.
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- teresa mLv 79 years ago
No I am not surprised. She was a cheater and home wrecker what else would you expect from a person like that? I do not have much respect for people that cheat with married people, I do not care if they are male or female. If a person belongs to another that means you keep your hands off.
How she ever got in to the government is beyond me. I never saw her run for anything and if I did she is not someone I would vote for.
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- Anonymous9 years ago
Female Mel Gibson: Tons of talent, needs attention, lacks anytype of understanding of issues outside of her little playland (between her ears).
We would never make a love story about a German or Ukrainian Jew falling in love with her Nazi German captor.
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- mattapan26Lv 79 years ago
Just a guess here, Scooter, but something tells me a movie with that plot line is not going to be a box office giant.
- Login to reply the answers
- Anonymous9 years ago
why do people even give this big lip punk any credit? she's a homewrecker ,which is not a judgement it's a FACT. she sucks. i'm tired of hearing about her, she's not special, why do people uplift these people? just because she adopts black kids doesn't make her special. celebrities in government= EPIC FAIL.
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- 9 years ago
I've always strongly disliked her, she seems like a stuck up snob.
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- Susan SLv 69 years ago
i don't think foolish movie-stars should be in government...the United States Government's citizens are not here for flaky actresses to make money. bah-humbug.
- Login to reply the answers
- lowlevelLv 79 years ago
I'm pretty sure she's done more good in this world than you or I or most other people have...
- Login to reply the answers


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>virgin until yesterday
>date a girl for some time, she didnt want any sexual contact until last night.
>made her came twice, my tongue is sore as hell. Watched some guides to make sure she comes
>at first could not get it up, fucking emotions
>got it working, missionary first, changed for her on top
>banged like a beta-virgin for 40 minutes
>condom on
>couldnt cum
How can i solve this shit? I think we'll try again tonight.
>pic related, me right now.
I'm not a man but there's lots of advice here such as getting a different condom size. Do u normally cum during fapping?http://www.steadyhealth.com/topics/having-sex-for-the-first-time-couldnt-cum
>fucking emotions
This has nothing to do with emotions.
Stop fapping and phisically abusing your penis while doing so.
Yes I do...most of the time in like under 5 minutes. Can't understand what happend.
Men dont have to cum every single time man, I bet next time you cum buckets.
I dont really give a fuck, i can cum while fapping. She feels unatractive somehow...
I would. Do you even have any idea how much of a fucking insult this is.
The point of a relationship is on the side of everything else, to do intimate things TOGETHER.
If you wanna fap by yourself (then not be able to get it up) then don't acquire relationships.
No I do not, this whole relationship is new for me. Never gave a fuck about it before.
So the solution is to stop fapping? This makes little to no sense to me, i fap like once or twice / week.
Do you watch porn? Maybe you should stop.
Yes it is. My husband NEVER ever faps. In 12 years relationship and 10 years marriage he's fapped maybe about 5 times for different reasons (most of them being me not available for helping out). And yes you talk about those things when you're close enough.
I'll stop fapping, hope it'll work.
Pls post results op
Had my first time
She is 24 and I am 18.
Had trouble to get it up and with a condom,
I just couldn't keep it hard she was already sore we tried without condom and holy fuck that was so good I could've keep fucking her like that for a long time
But I felt I was about to cum every secend and I would pull it out and didnt cum...
she came like crazy because I went down on her but she was a little sad I couldn't cum.
I would do anything to make her happy she's crazy with me.
But its the first time so I know I would be improved.
I just cant feel shit with a condom you are not the only one
Oh my god dont stop fapping man, thats stupid. Everyone has different needs. Not cumming has nothing to do with fapping. A woman has to be crazy insecure to feel bad about you fapping.


text:
8tracks will no longer be streaming music after December 31, 2019. Learn why here→
- You can export any playlist to Spotify or download the tracklist to a text file by clicking the buttons the mix art below.
- If you're an 8tracks DJs, you should have received an email that includes the tracklist of every playlist you've published; if you've not received this email, send us an email at email@example.com.
We appreciate all that the community has contributed to 8tracks over the years. Thank you for spending time with us. —
We at Juicy Glamour are one of the best agency who find and recruit only elite and top females in our agency in Delhi.
Member since Dec 2019


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Job openings
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text:
Separate names with a comma.
I'll be there a bit late, because I'm doing some important things, but I'll be there
In my opinion, this event needs to be postponed to tomorrow, because there's only 4 drivers that have confirmed...
Hi everyone! I was too busy, so I couldn't race... But tonight, I'm able to race
I have read the post and I want to rejoin. I've known Snail Racing League in 2018, when I entered in a Lobby
I'll not race anymore, because I start school on Monday. I'm from Argentina, so I have different time here. Good luck to everyone!
And remember,...
I Can do replays too
I will be there
Confirmed for Wildcard
Sorry guys, I am very frustrated right now. I can't understand why I was racing so Bad tonight. I think I need More Practice or something similar....
I will be a bit late
I was very frustrated for last night's race. I couldn't get the podium, but I really enjoyed it. I hope that my New steering wheel arrives soon....
I think Gran Turismo is having problems Like always
Thanks for all guys. I really enjoyed it. I am very happy with my first victory, I was so nervous! Have a nice week!
Can anyone remember what time does the race starts? I've forgotten it
I agree
Brands Hatch GP
I will be there
What cars are we going to drive tonight?
I am not going to be in tonight's race because I don't have Internet. Have fun and race clean!
Tomorrow I Wont be able to be in the race, because I have a party at night. Have a nice race!
Is the lobby open?


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We use cookies on this site to enhance your user experience
By clicking any link on this page you are giving your consent for us to set cookies.
Hey! I'm writing a drum corps show entitled "lost&found" and I need a battery and front ensemble arranger/arrangers! Message me and I'll send you an mp3 of the brass book to see if you're interested!
Does anyone want a piece of music for a certain instrument ?
And if you know this show me a tutorial on how to do that.
Is this group a Yiga Clan scheme?
If you do, would you like to share it with the group? Assuming we get a group?
anyone have ideas on how to improve the group?
i was hoping folks would share sound fonts and effects and more folks would share music with interesting effects.
ideas anyone?
A small composition i had composed back in January , but decided to uploaded now.
Please , check it out :
Hipe you enjoy !
Join my new banana group. Sure to be lots of sweet yellow slippery fun (whatever that means).
haven't did this in a while
Sorry but I thought that it should be done
I have now finished everything for Blue Devils 2019 except battery.
Feedback is welcome. Enjoy.
Check out this show!
It's a really nice show, I'm sure you'd like it. Please leave any feedback or commentary on the score itself. Please share with others as well!
still, a work in progress need feedback and a name for the piece I'm open to ideas I'm not going to get offended if you say it's not that good
how would I would I write in sizz sucks in mdl?


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More Posts
- [Free Pattern] The Tortoise Is One Of The Four Celestial Animals, Or Guardians In Feng Shui
- [Free Pattern] Learn A New Crochet Stitch: Stunning Flowers Crochet Stitch Pattern
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"This pumpkin is a conversation starter. With it in the middle of your table, people will be compelled to ask "why the big pumpkin" and you can say, "because Fall is awesome." Because Fall is awesome, right? With all the smells and flavors, Fall if my favorite time of year and decorating with fun (and huge) pumpkins is just one of the best things about it."
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Check out the original source for this Big Ol' Pumpkin Free Crochet Pattern with all the directions and full written pattern at: Divine Debris.
Thanks to Amber for the article inspiration and featured image.
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Eagle Scout Charles David Fletcher from Orem completed Navy Basic Training on August 9, 2014 at the Recruit Training Command in Great Lakes, Illinois. He was selected as one of nine Honor Graduates, one from each division, out of over 750 recruits. He was called out at graduation exercises and saluted by the commanding officer. Charles was awarded an additional rank for being an Eagle Scout. He currently holds the rank of Airman and is attending A School in Pensacola, Florida studying Aviation Electronics.
Charles was identified as an exceptional leader during the first week of Boot Camp. He was chosen to lead his division. The division commander referred to him as "The *!?% &^+! Genius". He led by example. In considering how to fulfill his division's watch assignment he decided that he didn't want the sailors to be able to complain about their assignment, so he assigned himself extra watch duty each week.
During the first week of training the recruits were all standing at attention in the field. Charles, as a leader of the division was on the front row. The commanders were having a heated conversation, but were speaking in Spanish so that the recruits would not understand. Charles said that he tried to contain himself, but at one point he couldn't help himself and burst out laughing. The commander immediately came up to him and shouted: "Fletcher, you are from Utah. How do you know Spanish?". The recruits are taught to respond in a way that all members of the division can hear. Charles shouted back: "I served a mission to Chile, Sir!". The commander replied: "What religion are you?". Charles shouted back: "I am a Mormon Sir!". So, now it was out. He was the only Mormon in his division.
The recruits were allowed to attend church services each Sunday, but were told that they really needed this time to study. Charles informed his division that he would be attending church for three hours each Sunday and believed he would be blessed for doing so. He told them that when he got back he would spend the rest of the day helping whoever was struggling the most with their lessons. As a result of these sessions his division became the top performing division for that training cycle. They earned all possible battle flags including the prestigious "Battle Ready" flag. After 8 weeks of training 10 sailors were attending church with Charles.
Charles credits much of his success in Navy Basic Training to the leadership skills he learned in Scouting. He served as Patrol Leader then Senior Patrol Leader in his troop, Team Captain, and Crew Chief. He served on camp staff at Camp Jeremiah Johnson then Camp Maple Dell for several years as a lifeguard and Canoeing/Rowing instructor. He was a Timberline NYLT participant as well as a staff member twice (first as an Instructor, and then as Assistant Senior Patrol leader). He said that the lessons he learned at Timberline NYLT were critical factors contributing to his success in the Navy.
Author: Sam Fletcher | Orem District, Utah National Parks Council, BSA


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Open Rank of Psychiatry and Behavioral Sciences in Community Behavioral Health - req# 11886
Job Description
Open Rank of Psychiatry and Behavioral Sciences in Community Behavioral Health
|Posting Number
|Employment Type
|Faculty Type
|Open Rank
|Hiring Department
|Psych Community Behavioral Health (451E)
|Academic Location
|School of Medicine
|Benefits Eligible
|The University of New Mexico provides a comprehensive package of benefits including medical, dental, vision, and life insurance. In addition, UNM offers educational benefits through the tuition remission and dependent education programs. See the Benefits home page for more information.
|Position Summary
The Department of Psychiatry and Behavioral Sciences at the University of New Mexico Health Sciences Center is accepting applications for an academic faculty forensic psychologist, suitable for appointment at the rank of Assistant or Associate Professor. This assignment will be through the department's Division of Community Behavioral Health. Broad based forensic skills to include knowledge of the law in relation to clinical practice are central to this position. The position will work extensively with criminal justice agencies and the New Mexico Human Services Division, delivering forensic behavioral health assessments and be responsible for a range of duties related to legal proceedings, including analysis of legal issues and how they stand within the legal jurisdiction in question, and using a research-based approach to answer legal questions or problems. This position will include a combination of research/scholarly activities, educational activities to include the management of the existing forensic post-doctoral program and the ability to participate in direct forensic services in the community.
More specifically, roles and responsibilities of this position will be as follows:
Albuquerque is New Mexico's largest city and is located in the heart of the Rio Grande Valley with stunning natural beauty. We are eager to put together the right package for an individual with a passion for the intersection between Psychology and Law, and an interest in joining a team of talented, caring and committed faculty members. Salary and academic rank are commensurate with experience and academic background.
Minimum Requirements:
Preferred Requirements:
|Application Instructions
Only applications submitted throughthe official UNMJobs site will be accepted. If you are viewing this jobadvertisement on a 3rd party site, pleasevisit UNMJobs to submit an application.
This position will remain open until filled. A selection committee will invite the most promising applicants for interviews. A complete application will include a cover letter addressing each of the minimum and preferred qualifications and describing the applicant's accomplishments and future goals; and a current CV.
|For Best Consideration
|For best consideration, please apply by 3/13/2020. This position will remain open until filled.
The University of New Mexico is committed to hiring and retaining a diverse workforce. We are an Equal Opportunity Employer, making decisions without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, veteran status, disability, or any other protected class.
Application Instructions
Please click on the link below to apply for this position. A new window will open and direct you to apply at our corporate careers page. We look forward to hearing from you!Apply Online
Posted: 2/17/2020
Job Reference #: 11886


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Rank: Civic Pride Civic Points: 250
concrete in my yard Archived318 Stevens St W St Paul, MN - West SideDoublas park upkeep is so bad! Not only is there an ancient rusty fence, but big old chuncks of concrete under the fence. There are grapevines invading my yard, the trees, and weeds are taking over the play sand
Douglas Park Weeds and fence Archived318 Stevens St. W St Paul, MN - West SideI posted a complaint a view days ago about the weed taking over the park/sand and how the grapevines are totally out of control. Although I appreshiate the speedy attention my request got, the actually response has got to be a joke.
I am posting pictures, there you can see the rediculous attempt at containing the weeds and the grapevines. Pretty much nothing has changed.
Douglas Park St. Paul, MN - West SideThere is a fence with grapevines out of control. The vines are growing into the trees, suffocating all, growing on my house. Weeds are growing rampant. The vines are 20 feet tall, invading my house and garden. The fence is ancient and needs to be replaced. I am extremely fed up. I posted a complaint about this fence over a month ago, and still have not heard anything.


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Sentinel Island is a granite island, with an area of 10 ha, in south-eastern Australia. It is part of Tasmania's Sentinel Island Group, lying in eastern Bass Strait off the north-west coast of Flinders Island in the Furneaux Group. Until 1985 it was used for grazing sheep.[1]
YouTube Encyclopedic
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Sentinel Island Group
The Sentinel Island Group includes:
- Sentinel Island
- Gossys Reef
- Little Island
Seabirds and waders recorded as breeding on the island include little penguin, short-tailed shearwater, common diving-petrel, white-faced storm-petrel, silver gull, Pacific gull, Caspian tern and sooty oystercatcher. The metallic skink is present.[1]
See also
- ^ a b Brothers, Nigel; Pemberton, David; Pryor, Helen; & Halley, Vanessa. (2001). Tasmania's Offshore Islands: seabirds and other natural features. Tasmanian Museum and Art Gallery: Hobart. ISBN 0-7246-4816-X


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The last time I saw him he was walking down lover's lane holding his own hand.
— Fred A. Allen
My sorrow, when she's here with me, thinks these dark days of autumn rain are beautiful as days can be; she loves the bare, the withered tree; she walks the sodden pasture lane.
— Robert Frost lane quote
You can't drive straight on a twisting lane.
— Proverbs
I always won in my imagination. I always hit the game-winning shot, or I hit the free throw. Or if I missed, there was a lane violation, and I was given another one.
— Mike Krzyzewski
The trouble with life in the fast lane is that you get to the other end in an awful hurry.
— lane quotation by John Jensen


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Where is "get album art" option?
View Single Post
10th July 2012, 20:20
Batter Pudding
Major Dude
Join Date: Jun 2008
Posts: 1,665
The "Paste Artwork" button is easy to use with a handy web browser. Use Amazon, Wikipedia or Google Image Search to locate album art. Right click on the image as you see it in your web browser, and copy. Then use the "Paste Artwork" button in the Winamp Artwork dialog.
This way allows you to pick up higher quality artwork. Also lets you find rarer albums that were not picked up by the old method.
Don't put in art that is too big though as you may end up causing yourself different problems.
Batter Pudding
View Public Profile
Find More Posts by Batter Pudding


text:
Please use this identifier to cite or link to this item:
|Methylprednisolone therapy in aplastic anaemia: Correlation of in vitro tests and lymphocyte subsets with clinical response
|S. Issaragrisil
Y. Tangnai‐Trisorana
T. Siriseriwan
S. Chinprasertsuk
A. Piankijagum
S. Sarasombath
Division of Haematology
Mahidol University
|Issue Date:
|European Journal of Haematology. Vol.40, No.4 (1988), 343-349
|20 patients with aplastic anaemia were treated with methylprednisolone 1 g/d for 3 d followed by prednisolone 60 mg on alternate days. At 3 months after therapy, 7 of 20 patients (35%) showed recovery, 2 had died and 11 were non‐responders. Only newly diagnosed patients were responders. Results of in vitro tests were correlated with clinical response. The first test was designed to determine whether removing various subpopulation of cells would increase the numbers of progenitor cells. In the second test blood cells were collected at 1 month after starting treatment and assayed for progenitor cells. Data from both tests did not correlate with the response to therapy. Lymphocyte subsets were measured in the blood before and at 1 month after treatment. The absolute numbers of OKT3 +, OKT4 + and OKT8 + cells were significantly decreased compared to the normal population. The number of HNK1 + cells was also decreased but no significant difference was observed. Responders had a higher number of HNK1 + cells compared to non‐responders. No significant differences of OKT3 +, OKT4+ and OKT8+ cells among responders and non‐responders were observed. Therefore a high number of HNK1 + cells prior to therapy may identify patients responding to the treatment. © Munksgaard 1988
|Appears in Collections:
|Scopus 1969-1990
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Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


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missing mobile number
missing mobile number
missing mobile number
Unisex Full Rim Navigator Sunglasses - LI141C12
- Rs 1360
- MRP Rs 1700
- (20% Off)
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- Product Description
Allow yourself to create a lasting impression when you don this pair of navigator sunglasses from Life. It will surely set some eyes ogling and many heads will turn as you walk through the crowd. Also, it comes with a frame made of good quality material which lends it a great finish and the full rim enhances its design.
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Product Type Navigator Style Navigator Frame Style Full Rim Occasion Casual
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Enrich your look to be awesomely stylish with the latest trends by including this amazing pair of navigator sunglasses in your eyewear collection.
Life is an exclusive brand from Shoppers Stop that believes in the philosophy of todays youth. They live life to the fullest and make the most of every moment.
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text:
Introduction to Foundation Directory Online
Tue, February 25, 2020 10:00 A.M.
Regional Foundation Center at Parkway Central Library
Learn how to use everyone's favorite foundation funding database, Foundation Directory Online. The user-friendly interface makes it easy to find funders that are interested in supporting your organization's mission.
During this workshop we will explore the database interface and learn how you can find information on:
- Funder priorities
- Previously awarded grants
- Friendly competitors
This program is appropriate for both those that are new to the resource and those that would like a refresher.
We will also take a look at the newly updated GrantSpace.org which provides easy-to-use, self-service tools and resources to help nonprofits worldwide create more viable grant applicants and build strong, sustainable organizations.
We encourage you to follow along by bringing a fully-charged laptop with wifi capabilities.
Advanced registration is required as space is limited. Please register online here.
Tuesday, February 25 | 10:00am - 11:30am
Parkway Central Library | Ground Floor | BRIC
Event TypeWorkshops and Enrichment Discussion and Participation
Event SeriesRFC Program Calendar
Event TagsFundraising Nonprofit
Regional Foundation Center
BRIC, Ground Floor
Parkway Central Library
1901 Vine Street (between 19th and 20th Streets on the Parkway)
Philadelphia, PA 19103


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innovationXchange is DFAT's development innovation hub.
A celebration of Australia delivered in a country or region of strategic significance.
Ensuring Australia continues to build soft power and exercise influence effectively.
To help Australians avoid difficulties overseas, we maintain travel advisories for more than 170 destinations.
The Australian Passport Office and its agents are committed to providing a secure, efficient and responsive passport service for Australia.
Letter CANBERRA, 22 November 1943
The splendid progress of your operations has been the subject of
some thought on my part and discussion by the Government in
relation to your future plans and the area of employment of the
Australian Forces which have been assigned to you.
2. As you are aware, the territory of Papua is part of the
Commonwealth of Australia, and the Commonwealth Government holds a
mandate from the League of Nations for the administration of the
former German Colony of New Guinea and the former German islands
situated in the Pacific Ocean and lying south of the Equator,
other than the islands of West Samoa and the island of Nauru. The
mandate for Western Samoa was granted to New Zealand and the
mandate for Nauru to the British Empire but is administered by
Australia. The 'C' class mandates are in accordance with the
following provisions of Article 22 of the Covenant of the League:-
'There are territories, such as Southwest Africa and certain of
the South Pacific Islands, which, owing to the sparseness of their
population, or their small size, or their remoteness from the
centres of civilisation, or their geographical contiguity to the
territory of the Mandatory, and other circumstances, can be best
administered under the laws of the Mandatory as integral portions
of its territory, subject to the safeguards above mentioned in the
interests of the indigenous population.'
3. Australia therefore has a special interest in the employment of
its own forces in the operations for the ejectment of the enemy
from territory under its administration. Furthermore, it is
essential, under the terms of your Directive [1], that the
Government should be at least broadly aware of your ideas for the
employment of the Australian Forces in any areas outside Australia
and mandated territory, and of what you may contemplate in regard
to operations affecting the latter areas. You will appreciate also
that the Government must have regard to the legislative provisions
of the Defence (Citizen Military Forces) Act 1943 which defines
the limits of employment of the Citizen Forces. [2]
4. Although, by the most complete co-operation on your part, there
has never been any need to refer to the documentary basis which
governs your relationship to the Australian Government, you will
be aware that the position under the set-up in the South-West
Pacific Area in regard to consultations on such matters is as
(i) In amplification of the Directive, Dr. Evatt was furnished
with an official memorandum in Washington which stated that it was
explanatory of and should be read in conjunction with the
Directive of which it thus became part. [3] A copy was enclosed
with my letter of 15th April, 1942. [4]
(ii) Clause 2 of the Directive refers to the assignment of forces
by the Governments concerned.
(iii) Paragraph 1 of the official memorandum reads as follows:-
'With regard to the possible movement of Australian troops out of
Australian Territory, the following by United States Chiefs of
Staff to the President is self-explanatory:
"Proposals of United States Chiefs of Staff (for operations in the
South-West Pacific Area) made to the President as United States
Commander-in-Chief are subject to review by him from the
standpoint of higher political considerations and to reference by
him to the Pacific War Council in Washington when necessary. The
interests of the Nations whose forces or land possessions may be
involved in these military operations are further safeguarded by
the power each Nation retains to refuse the use of its forces for
any project which it considers inadvisable."'
(iv) The President, to whom, with Mr. Churchill, the Combined
Chiefs are responsible and to whom the United States Chiefs of
Staff are solely responsible, has never adopted the practice of
referring proposals of the United States Chiefs of Staff for
operations in the South-West Pacific Area to the Pacific War
Council, as mentioned in (iii). The position has been met by the
greatest co-operation on your part with the Australian Government.
5. The effective exercise by the Australian Government of its
responsibility to the people of Australia, in respect of the
employment of Australian Forces, requires that the Government
should be kept informed of proposals formulated for the employment
of those forces. It is, of course, highly desirable that such
information should be received at an early stage in planning. In
view, therefore, of the point of the progress reached in your
operations and national considerations which I have outlined, I
would greatly appreciate advice of prospective plans in regard to
the use of the Australian land forces, in order that the
Australian Government may consider their contemplated use.
6. It is, of course, unnecessary for me to add that this request
is not prompted by any desire to interfere in any way with your
conduct of operations, or to participate in the formulation of
plans. The Australian Government has at all times had the utmost
confidence in your handling of these matters, and is deeply
appreciative of the remarkable results you have achieved with the
limited resources at your disposal. My present request arises
solely from the responsibility to the Australian people which must
be exercised by myself and the Australian Government. [5]
2 The Defence (Citizen Military Forces) Act, which became law on
19 February 1943, provided that troops conscripted into the C.M.F.
could be employed anywhere in a 'South-West Pacific Zone', the
boundaries of which were the 110th meridian on the west, the
Equator on the north and the 159th meridian on the cast.
Conscripts (as opposed to those who volunteered for overseas
service with the A.I.F.) previously had served only in Australia,
Papua and the Mandated Territory of New Guinea.
3 See Admiral Ernest J. King's letter to Evatt of 10 April 1942
and Evatt's cablegram S37 of 12 April 1942 to Curtin on the file
cited in note 1.
4 Not found.
5 MacArthur replied on 24 November that he was 'in complete accord
with the general position outlined in your letter' and suggested
that he should give Curtin his 'general concept of the campaign'
at a meeting between them in Brisbane already arranged for 30
November. MacArthur pointed out, however, that he was 'constantly
receiving directives which modify materially my use of the forces
here and at the present time am still in doubt as to master
decisions with regard to the future. See letter on file Defence:
Special Collection II, Advisory War Council Section file (combined
with 65/301/118), Role of the Australian forces in Pacific 1943-
Category: International relations
Topic: History


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Let's change the way students and teachers participate in South Australia's History Festival in May 2020!
Students years 4-11
Throughout May, all schools throughout South Australia are invited to participate in a poetry-developing activity.
We encourage you to engage with museums and interpret museum collections in a different way. What does local history mean to you? Why are objects important and why should we care? Why would a museum have that particular object on display? What's the story?
Targeting HASS and English students from Years 4-11, students will be invited to pick a museum object, digital or non-digital, and write a poem relating to the theme 'changing identities'. It could be a haiku, a stanza, a verse, or a slam, written or recorded. Whatever form is most interesting.
Submissions can be written, or audio or video files, along with a picture of the object. At the end of May, the History Trust will share the poems through the History Festival Facebook and Instagram page (@historyfestival).
Visit your local museum and engage with their collections objects or access digital objects from the History Trust collections. To book a museum visit, please contact your museum of choice directly.
Please note, Poetry Takeover sessions do not need to be registered as an event for the program.
Guidelines for museums and galleries (PDF)
Download Poetry Takeover flyer (PDF)
General info:
This activity is open to students in South Australia from years 4-11.
Age groups will be split into three categories:
- Years 4-6
- Years 7-8
- Years 9-11
Poems will be inspired by a museum object. Students can engage with objects by either visiting a museum, or exploring collections online.
The theme of the poem is 'changing identities' (this sits with ACARA English years 4-11).
Up to a maximum 300 words per poem.
Only one entry per student. Teachers can select their 10 best poems from the class to submit.
Teachers can submit poems by direct message on the Poetry Takeover Facebook page or by email.
Each poem to be accompanied by an image of the object (please ensure you have permission to capture and share the image).
Entries to be submitted by Friday 29 May.
More info: How to participate and Terms and Conditions (PDF)
Contact us for further enquiries.
Connect with your local school or museum
Download a list of schools, community museums & galleries by council area (PDF)
Check out the Explore History website
Poetry Takeover Resources:
Reflection cards (PDF)


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Revelation 2:18 "And to the angel of the church in Thyatira write: The Son of God, who has eyes like a flame of fire, and His feet are like burnished bronze, says this:
Jesus is connecting many dots with this initial statement to the church at Thyatira. He is identifying Himself with references to Scripture. There are three characteristics in the verse that point to the person of Jesus Christ…1) the Son of God, 2) who has eyes like a flame of fire, 3) and His feet are like burnished bronze.
The Son of God. Jesus Himself is identifying Himself as the Son of God. The idea that God has a Son is noted in the Old Testament.
Psalms 2:7 I will surely tell of the decree of the LORD: He said to Me, "You are My Son, Today I have begotten You."
The Son is confirmed by the Father Himself in the Gospel accounts. One example is in Mark with John the Baptist in the Jordan River. All three persons of the Trinity are present.
Mark 11:1 and a voice came out of the heavens: "You are My beloved Son, in You I am well-pleased."
Even the demons know Jesus is the Son of God.
Luke 8:28 Seeing Jesus, he cried out and fell before Him, and said in a loud voice, "What business do we have with each other, Jesus, Son of the Most High God? I beg You, do not torment me."
Satan knows Jesus is the Son of God in Matthew 4.
…eyes like a flame of fire…One person in the Bible has these kind of eyes, Jesus Christ. This is His description at His second coming.
Revelation 19:12 His eyes are a flame of fire…
John, the author of Revelation describes Jesus with eyes like fire.
Revelation 1:14b …and His eyes were like a flame of fire.
Daniel's description of a man dressed in linen fit.
Daniel 10:6a His body also was like beryl, his face had the appearance of lightning, his eyes were like flaming torches…
…His feet are like burnished bronze…
John describes the feet of Jesus in the Patmos vision.
Revelation 1:15a His feet were like burnished bronze, when it has been made to glow in a furnace…
Daniel's description of the man dressed in linen (garments of a priest) by the river had descriptive feet.
Daniel 10:6b …his arms and feet like the gleam of polished bronze…
This is what Jesus is going to look like. Just add white hair, crowns, and a red robe on a white horse.
Available in ebook and paperback at Amazon.com
Also available online at Barnes & Noble, iBooks, Kobo, and Inktera
- Gabriel: Jesus Is Coming - February 9, 2020
- Wuhan Virus Update, February 7, 2020 - February 7, 2020
- Where Is God??? Joshua of Ghana - February 6, 2020
- The Primary Purpose of the Gospel – And an Accurate Perspective… Rodna Epley - February 4, 2020
- Locusts Sweeping Across the Middle East - February 1, 2020
- Weathering the Storms of Life… Christine McDonald - January 31, 2020
- Trump's Deal of the Century - January 30, 2020
- Gabriel Covers Mary in Grace - January 26, 2020
- Wuhan Coronavirus Spreading Across Asia - January 22, 2020
- Gabriel's Resume - January 19, 2020


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As part of the new security arrangements, the entry and unauthorised parking of private vehicles on the Civil Station compound will be restricted from July 10.
Only those vehicles carrying stickers issued by the Collectorate will be allowed to enter the Collectorate premises and use the dedicated parking space.
The heads of most government departments have already handed over details of their vehicles and those regularly used by their subordinates to secure the stickers and comply with the latest instructions. Police officers are likely to be posted in front of the gate to prevent the entry of unauthorised vehicles.
The restriction has been imposed mainly in compliance with the fresh security instructions issued by the police and intelligence authorities.
Nation-wide alert
The nation-wide alert against terror attacks has also prompted the authorities to come out with stronger checks and surveillance on the Collectorate compound.
An officer in charge of implementing the new security arrangements said all abandoned vehicles on the civil station premises would be cleared soon in consultation with the departments concerned. On Sunday, five such vehicles were removed to the yard arranged for the purpose, she said.
Officials made it clear that the new security arrangements would in no way restrict the freedom of people arriving at the civil station. Similarly, it would not affect the entry of vehicles to the civil station compound for official or emergency purposes, they said.
A few years ago, tight security had been recommended for the Collectorate and the Collector's camp house following threats from suspected Maoist supporters. Former Collector N. Prasanth had handed over the details of threats he received from various corners to the police for action. However, the police had been failing to address the concerns citing shortage of manpower.


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Posts Tagged Carpenters
November 27, 2019 by Simon Sweetman
The Vinyl Countdown # 210Carpenters, Horizon (1975) Been on a big Carpenters trip lately, and though they've been in my life forever it's only now I realise that I'm a Greatest Hits-player…well, I know a few of the albums but this is the first time I've decided to listen through to them all. There's some great lesser known gems […]
November 22, 2019 by Simon Sweetman
Five Songs For Friday: 33 – 5 O'Clock WorldsI'm a big fan of the 5pm Friday music; the perfect album – or playlist – something you put on for the walk home for work, maybe to soundtrack the first pour or even let you drift off for a wee quick snore; some music to celebrate the end of the working week. As the […]
November 21, 2018 by Simon Sweetman
Poem: A Ham Sandwich Walks Into A Bar…The old joke has it that if Karen Carpenter and Mama Cass had just shared the same ham sandwich they'd both be alive today. It's hilarious – because one of them was rather thin, the other not so much. they both died due to conditions of the heart. (I've no idea where the ham sandwich […]
March 6, 2018 by Simon Sweetman
The 1001 Albums Challenge # 38: Carpenters – "Close To You"I am a born-again Carpenters fan – the tribute album If I Were A Carpenter probably made more of an impact on me than the original songs (first time around). That changed rather quickly though…those original recordings by the Carpenters – pretty special. Maybe more so with the passing of time. As we get older […]
April 11, 2017 by Simon Sweetman
I Am A Carpenters Fan: To Be Born AgainThe Carpenters were brother and sister duo, Richard and Karen. She would turn down any kind of drumstick other than the kind used to play music. He was a piano teacher interested in jazz and classical music; interested in arranging and composition. It took me a while to understand the appeal of The Carpenters – […]
October 9, 2016 by Simon Sweetman
Jesus Was A Carpenter: Carpenters Greatest Hits vs. The Carpenters Tribute AlbumThere is a lot of music that I don't like. Just as any of you will have your own likes and dislikes. My favourites are always changing – and I'm in the business of always trying to reassess; reappraise. So, on a recent flight I decided I had to listen to the Carpenters. I was […]
July 25, 2016 by Simon Sweetman


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Re: Signs It's Time To Replace (or not) That "Worn out" LP
Posted: 08 Jun 2019 04:04
I have developed a very effective method of cleaning my vinyl ( i buy LOTS of used vinyl ) and i love how we all have 'found' our way ...that works for us. I won't go into the nitty gritty (pun intended!) but will say for the record that Blue Dawn dish detergent is a key ingredient. Absolutely incredible results on all manner of used/dirty/worn vinyl.


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Take Inventory and Do a Balance Sheet It is important to understand why you are thinking of quitting the smoking habit 80 mg super levitra sale strongest erectile dysfunction pills, trying to be as specific as you can cheap super levitra 80 mg with visa erectile dysfunction organic. For example buy super levitra cheap erectile dysfunction and zantac, don t just say you are quitting for health order kamagra effervescent amex, instead state I am more short of breath climbing up stairs on a run or forcing entry than I was a few years ago or my doctor says my lungs and heart are being damaged by my smoking order discount cialis extra dosage. Take the list out and review it frequently; a great time to review your list is while smoking. A particularly good technique: One fire fighter who was quitting for his wife and family placed a picture of them without him between the cellophane and his pack of cigarettes. Every time he smoked, he imagined his family surviving without him after he died from a disease caused by tobacco. Avoid People, Places, Things You Associate with Smoking Take some time to detail the things that make you smoke automatically or more than usually. Where possible, change these behaviors to make smoking inconvenient, difficult, or impossible. For example, if you smoke while drinking coffee simply hold the coffee cup in a different hand; stand instead of sitting (or vise-a-versa), and/or hold a handling substitute such as a pencil or pen or eating can help you disassociate coffee from cigarettes. If you always smoke while driving to and from work try taking a different route and use oral or handling substitutes such as sugarless chewing gum or cinnamon sticks. Self-Help for Tobacco Dependent Fire Fighters and other First-Responders Likely Times for Smoking or Using Tobacco Check all that apply: Alcohol Coffee / Other beverages After meals While driving Boredom Work break/After a run After awakening Before bedtime Before / during a bowel movement During stress / anxiety After sex With negative feelings (anger, sadness, etc. This is not to say that a smoker must forever abstain from alcohol to quit, but it is probably a good idea to avoid alcohol while you are attempting to quit. A comprehensive discussion of the relationship between alcohol and tobacco is beyond the scope of this chapter. That said, alcohol and fire fighter social activities often go hand and hand and the stress first responders experience in dealing with life and death events can lead to alcohol use, which then can trigger tobacco use in smokers and (even more unfortunate) can precipitate a return to tobacco in ex-smokers. Sadness, Depression and Post Traumatic Stress Unfortunately, first responders see things that civilians only dream about in their nightmares. Witnessing tragedy up close and personal can cause feelings of despondency and other emotional problems. Self-Help for Tobacco Dependent Fire Fighters and other First-Responders 337 and while anyone can temporarily experience one or a few of the symptoms described below, if the symptoms are recurrent and cause significant problems in your life, seek professional assistance. Both depression and post-traumatic stress can increase the difficulty of conquering your tobacco addiction. The Money You Save Calculate how much you are saving by smoking less (or not smoking at all) and place this money in another clean clear jar. If you smoke one pack per day at $6/ pack, the savings after one year can pay for a large ticket item such as a vacation. All that matters is that you are cognizant of the fact that you are rewarding yourself for this important step. Changing unhealthy habits and replacing them with healthy ones is always a great idea. Starting an exercise program or increasing the intensity and/ or session length of a current program is one of the best things you can do to help you quit tobacco.
Follow-up of asthma from childhood to adulthood: influence of potential childhood risk factors on the outcome of pulmonary function and bronchial responsiveness in adulthood generic super levitra 80 mg with visa impotence pills for men. Spontaneous improvement in bronchial responsiveness and its limit during preadolescence and early adolescence in children with controlled asthma purchase genuine super levitra on-line psychological reasons for erectile dysfunction causes. During sleep onset super levitra 80mg on line erectile dysfunction treatment singapore, stage 1 sleep is seen with its characteristic slow rolling eye movements and easy arousability finasteride 1 mg otc. A representative sample of sleep from a healthy young adult without sleep complaints buy extra super cialis paypal. The homeostatic drive quantifies the physiologic need to sleep, and the circadian pacemaker ensures proper timing of the sleep process. Circadian Rhythms The word circadian is derived from Latin roots circa (about) and diem (a day). The term circadian rhythm refers to any behavior or physiologic process that is known to vary in a predictable pattern over a 24-hour period. First, inputs such as light and activity help synchronize (entrain) to the environment. Examples of these output pathways include lung function ( 9), sympathetic tone (10), and urine production (11), all of which vary over a 24-hour period so that optimum performance occurs during the daytime. Recent investigations have illuminated much about the site of the circadian pacemaker. There are nine currently identified genes that participate in a feedback system to regulate circadian processes. In animal models, significant modifications of these genes alter rhythms of sleep and activity ( 15), and there is a human disorder advanced sleep phase syndrome characterized by sleep which itself is normal but is temporally displaced ( 16). Sleep as a Homeostatic Process Homeostasis is the process by which the body maintains stability. Thirst, hunger, and temperature are all processes that are carefully regulated to ensure optimal function. These types of studies highlighted the use of a daytime multiple sleep latency test to quantitate sleepiness by measuring several times over the course of a day how quickly a subject could willingly fall asleep ( 17). The goal of the sleep homeostatic process is not well defined or understood; however, current models hypothesize that maintenance and remodeling of synaptic connections may be involved (19). Two-Process Model The two-process model of sleep regulation has been used to explain the relationship between circadian rhythm regulation of sleep (process C) and the homeostatic drive to sleep (process S). Both processes S and C have an impact on sleep regulation, and to promote optimum sleep quality, maximum sleep debt should intersect with appropriate circadian time (20,21).
This disease is mediated by an immunologic response in the lung to an inhaled organic antigen 80mg super levitra fast delivery erectile dysfunction diabetes qof. The most common types are due to ongoing exposure to birds such as parakeets or pigeons (bird fancier s lung) proven 80 mg super levitra erectile dysfunction protocol pdf free. The offending antigens are proteins present in the bird droppings that become aerosolized 80 mg super levitra visa erectile dysfunction foods to avoid. Another common cause of hypersensitivity pneumonitis is exposure to mold discount 25mg clomiphene visa, as in moldy hay (farmer s lung) order 20 mg cialis soft with visa. There are other types of chronic inflammatory lung disease of unknown cause that sometimes lead to fibrosis such as sarcoidosis. Sarcoidosis causes a specific pattern of inflammation that the pathologist recognizes as a granuloma, composed of activated macrophages (also called epithelioid giant cells) surrounded by lymphocytes in a spherical configuration. A small minority of individuals with sarcoidosis will progress to irreversible pulmonary fibrosis. Usually the joint or skin disease is present for a long time before lung involvement occurs, but rarely, the lung disease can be the initial manifestation of these systemic disorders. These generally have a somewhat better prognosis than idiopathic pulmonary fibrosis, a condition of unknown cause. Pulmonary fibrosis can also occur as a complication of certain types of chemotherapy prescribed for cancer treatment. The best known example is bleomycin, a drug used to treat lymphoma and testicular cancer. This drug reproducibly causes pulmonary fibrosis in certain strains of laboratory mice, so is used as a standard animal model for research on pulmonary fibrosis. Another commonly-employed cancer treatment, external beam radiation therapy, can cause radiation pneumonitis and fibrosis in a minority of individuals. The acute symptoms may begin within several weeks following radiation to the chest for treatment of lung cancer, breast cancer or lymphoma. The remaining types of interstitial lung disease are termed idiopathic, meaning having no known cause. The most common types of idiopathic interstitial lung disease are termed idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. The reason that an accurate diagnosis of the specific type of interstitial lung disease should be made is that the prognosis and potential for response to treatment as well as the dose and duration of treatment recommended is dependent upon the specific diagnosis. Cryptogenic organizing pneumonia is an inflammatory disorder that follows a viral infection and a variety of other acute insults to the lung.
In these cases super levitra 80 mg generic finasteride erectile dysfunction treatment, weaning may be necessary to help re-train the patient s muscles or more likely to provide repetitive assessments to allow both the patient and medical team to gain confidence that the underlying condition has improved to the point where spontaneous ventilation could be successful 80mg super levitra overnight delivery impotence after prostatectomy. Some clinicians favor one daily trial with gradually lengthening duration buy 80 mg super levitra with mastercard erectile dysfunction pills over the counter, while other favor several daily trials of shorter duration 100 mg zithromax otc. In practice cheap cialis extra dosage 50 mg fast delivery, at least at the beginning of the weaning process, most clinicians wean patients primarily during the day and return them to a more comfortable mode of mechanical ventilation during the night. No technique for weaning has been unequivocally shown to be better than any other. In most jurisdictions, intubation and mechanical ventilation can legally be withheld in such cases on the basis of medical futility. All patients with chronic disease and their families should be encouraged to avoid this stress and instead to make their wishes known early on, before the threat of respiratory failure. They remain empowered to change their decision at any time as their condition, circumstances or outlook changes. It is defined as a failure of gas exchange, either for oxygen, for carbon dioxide, or both. Considerable progress has been made in improving the delivery of ventilatory support, especially in the relatively recent development of safe and effective forms of noninvasive ventilatory support. Ventilation with lower tidal volumes for acute lung injury and the acute respiratory distress syndrome. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Evaluation of a decision aid for making choices about intubation and mechanical ventilation in chronic obstructive pulmonary disease. Patient preferences for communication with physicians about end-of-life decisions. A major effort of the Northwestern Allergy-Immunology program has been the diagnosis and management of all forms of asthma. Research funding from the Bazley Trust has made many of our accomplishments in the area possible. Preface The sixth edition covers allergic and immunologic problems that are encountered in the ambulatory practice or in hospitalized patients. The quantity and complexity of general and specific knowledge in the field of Allergy-Immunology continues to expand at an exciting but daunting pace. Further, the practice of Allergy-Immunology requires familiarity with many specific details. The 42 chapters contain useful, applicable, and up-to-date information on how to diagnose and manage nearly all of the conditions in Allergy-Immunology. The history of Allergic Diseases: Diagnosis and Management through six editions includes being a useful textbook where important, crucial information can be found and applied. Edition six has 15 new chapters, and the classic Drug Allergy chapter originated by Richard DeSwarte has been divided into three parts.
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Chlamydia screening is not cost-effective
SCREENING for the sexually transmitted disease chlamydia seems to make perfect sense. Most carriers of the bacterium show no symptoms at first, so testing is the only way doctors can identify who needs treatment and so help protect women from the pelvic inflammatory disease or infertility that can result.
Every averted case of pelvic inflammatory disease or infertility could cost £22,000
However, a study now suggests that proactive screening – in which patients are invited to attend clinics for testing – represents poor value for money. This approach to screening is currently being piloted in England, says Pelham Barton …
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Everything posted by grimness
I use BWM (s) - DPL (d) - BWM (s). DLP has lower mentality than CM and BWMs have higher closing down than B2B so they should cover more width defensively.
My Liverpool attempt: Help needed
grimness replied to daleuk8's topic in Tactics, Training & Strategies DiscussionCleon recreated it faithfully with Swansea IMO. Without ball you get defensive positioning of 4-5-1 and offensively you get 4-2-1-3. Transition looks fluid and overall it looks much better than sticking with 4-2-3-1 as a starting formation.
Huge number of changes in your DB. Gonna try it out and see how playing feels with lots of future transfers.
Football Manager Tactics - YouTube Series
grimness replied to Flamers's topic in Tactics, Training & Strategies DiscussionChemnitz videos are great! I'm yet to see Spain ones. Since you have 3 at the back, without offside trap, have you tried to stagger center backs? Simplest way is to have middle one on cover. Cleon had interesting approach of having (left to right) stopper, regular defender and cover. Ball winner was positioned on the right side of central midfield so he dropped back in front of the covering CB.
Might be injury related. I'll keep an eye if it happens again. I don't use save game editors.
For some reason my players left declined over time. Example I remembered is David Lopez from Athletic Bilbao. He starts with Strong left foot which declined in less than two seasons to Weak for some reason.
I think that players improve in that part. I've had players loosing skill in their weaker foot when declining due to lower ball control training and lack of matches. So probably training has some influence over it.
Selling a Used FM 2012 Game?
grimness replied to REALGSA1's topic in Football Manager General DiscussionUse his Steam account offline to play the game?
25% off FM13 pre-order.
grimness replied to daylight's topic in Football Manager General DiscussionYet Croatia gets EUR prices. I should go across the border with laptop and order
Selling a Used FM 2012 Game?
grimness replied to REALGSA1's topic in Football Manager General DiscussionI've read that it is possible to deactivate your game on Steam however you have to contact them first as it's not automatic so best bet is to do so and see what they say.
SI/Sega Greed on Australians.
grimness replied to davidbowie's topic in Football Manager General DiscussionUsually I pre-order hard copy from UK cos Steam is rip-off. However this year I paypaled money to friend in UK and he sent it to me as a gift after the game was out. Saved me some money. No way I'm paying the game in Euro. Pre-order in combo with little bit of voucher hunting gets the price below 20 GBP, then it's all about postage price.
I'm playing Sweeper and Libero is on Attack if I'm chasing the game. Centerbacks are on standard defend, might use BPD if I have good passer. Had wingbacks on automatic but changed it to attacking for last 2 games, which isn't much. However I plan to use them that way in my dedicated 3-5-2 save.
SW - CB CB - WB WB - MC MC - AMC - FC FC and FB CB FB - DMC - MC MC - AMR AMC AML - FC I change roles depending on the players available and also according to opposition. Starting strategy is Standard but for 3-4-3 I might change for Counter. In 3-5-2 Standard is lowest I go cos by default team will be very well positioned defensively and anything lower than that will make you useless offensive wise. With 3-5-2 only goals I conceded were long shots and corners so it's good base to build from.
http://bit.ly/TBjeJ5 If you are interested in recreating Van Gaal's Ajax. This year I've been leaning more toward Bielsa with direct approach. In case of both I use FBs and one CB with DMC in front of them. Difference is only in passing range and use of wingers or inside forwards. In both cases I have to manually assign marking according to opponents formation. FBs man mark two forwards or wingers in case of 4-3-3 and DMC is man marking central forward against 4-3-3 or eventual AMC. It works OK. This year I've been using it with lower Croatian team and reached Champions league group stage twice in a row were I was punching bag. Back three I prefer to be centerbacks who are able to play in FB position. Shouldn't be a problem to find them in Italy, Napoli for example has suitable players and I think that default or updated squad is best for experimenting with 3 man defense. Their offensive potential is good so it should give you safe season to experiment. With 3-4-3 I was able to score 3 against Liverpool with really poor team. I've leaked 7 cos my defenders were under 10 in all physical attributes and mental ones were even worse but still it was fun.
I personally go for 3 CBs when playing with wingbacks and with 3 wide defenders when playing Ajax 3-4-3. However since 3 wide defenders seem to work slightly better I would use them if I would go for 3-5-2 variations when wide midfielders are used instead of wingbacks. I'm currently playing with variation of 3-5-2 from Icelander's tactic video thread so I'm using Fluid. Usually I'm going for Balanced. These days I'll start Napoli or Udinese save and will try Balanced to maximize offensive potential of wingbacks.
I've found wingbacks to perform better than wide midfielders. In 3-5-2 and in Brazilian 4-2-2-2 I believe that attacking role is a necessity for full offensive potential. It's also useful to occasionally play wingback on his "wrong side" as he will be inclined to cut inside when he reaches penalty box. In my current South American save with all SA leagues and large DB I still have a problem of finding good left backs, so I had to play right backs there and even with competent skill I had some amazing goals due to cutting inside. They fall back into defensive line so pace, stamina and squad depth are good to have as well as in Brazil they can hardly play 3 games in 7 days.
I've switched positions of my forwards as they are both right footed. Since proper target men most of the time play with their back to the goal it's easier to distribute the ball to AMC and Trequartista. Also for Trequartista it's easier to pass the ball when he has players on his left.
I've tried your 3-5-2 with Vasco for one tough game against Santos. It wasn't exactly my first 11 due to injuries but I've really liked what I've seen. It was a blast from the past and like watching games from the era of 3-5-2, then it was more direct play, probably due to worse pitches My front two were suited for your roles. What I really liked is that Target man isn't static, he moves around decently (for target man) but when I switched to Exploit the flanks shout he was often on the byline. Surprisingly wingbacks do a good job. Defending in line with stoppers but they really attack as they should instead of stopping on the halfway line like they used to. Thanks for giving me back interest in FM!
Luketa maybe you should go with Counter from the start to see how it goes?
[FM 2012] 4-4-2 Box Midfield Project
grimness replied to Uncle_Sam's topic in Tactics, Training & Strategies DiscussionBump for this excellent thread
Having player at the left wing is how it's 4-3-1-2 played nowadays. Usually second striker is on the left wing since most of the players are right footed so cutting inside can be more effective but one can be positioned on the other side. Some of the real life examples of having second striker/inside forward are Napoli (Lavezzi), Milan (Robinho), Santos (Neymar), Inter (Eto'o) etc.
Co Adriaanse's 3-3-4 & The Dutch Philosophy
grimness replied to Zico10's topic in Tactics, Training & Strategies Discussionhttp://www38.zippyshare.com/v/3846232/file.html
Libero & The Invisible Wall
grimness replied to Tactikzz's topic in Tactics, Training & Strategies DiscussionHaving grew up watching games every second week where everyone played with back three I can say that not once I've seen Libero playing as Beckenbauer did. Basically what was known here as Libero is in English known as Sweeper and it was usually position for the best and oldest defenders who would command defense. I believe that Libero role in FM is just modification of Sweeper as I really don't know how many players in that position bombarded forward during the game. Of course as a fan of back three I would love to see some flexibility within match engine so we can replicate some historical systems.
In my experience player reputation and CA and PA during playing career has no influence on CA and PA as a coach. Reputation is carried over from playing to coaching and usually means absurd wages. For example world star is retiring at the end of the season and I offer coaching position and wage request is over 100k EUR per month. And this happened to me more than once. On my Inter save I had 4-5 players retiring at the same time and wage requests were getting crazier with each player. SFraser noted his finding and disappointment that most of the players get coaching potential limited to 135 after retiring.
The FM 41221 (433 - 451 - WoW)
grimness replied to furiousuk's topic in Tactics, Training & Strategies DiscussionGreat thread! Unfortunately I don't have much to add but I'd like to point that certain variations of 4-2-3-1 are actually variation of 4-3-3. Cruijff calls it "midfield with point forward". And from what I get some people aren't that much offtopic even though thread is about "midfield with point backwards". Here is Cruijff's column with google translate on his views of 4-3-3. I hope everyone will find something interesting. http://tinyurl.com/cju622a


text: Found this on the Weatherzone forums here (also Victoria 2007 prediction to be found there): January & February Unsettled conditions are likely later in January and early in February. Hot and mainly dry conditions are likely during February, especially later in the month. March & April With El Nino likely to breakdown during March, I think we may see from mid March a few good ECLs or other events producing heavy rain along the NSW coast. (with the north, central, and south coasts/ranges likely to receive a similar amount of rain, tending a little higher in the north). Regions west of the ranges are likely to receive below average or average rain from fronts and troughs. April should be a very wet month across the state (tending wet in the west) with a continuation of 'solid' rain events in NSW. May & June Then as we head into May we should see a continuation of wet conditions on the coast with similar conditions likely to March/April, though generally weaker the further you head west. During June we should start to see NW Cloudbands moving southeast across the country bringing average or above average rain to areas west of the ranges, though as usual NW Cloudbands will not deliver much rain to the coast (generally less than 10mm) so drier conditions are likely during June on the coast though a few strong fronts will bring some rain (but still below average), with less rain likely the further north along the coast you go but these strong fronts are likely to bring very good snow to the Snowys and a few good snow dumps on the southern and central ranges which should please those snow chasers. July & August Cold and dry with little snow is the name of the game for July in NSW, due to conistant highs moving across southern WA, southern SA, VIC, and southern NSW, which will block or weaken fronts before they hit NSW, with the Snowys likely to only get one decent dump of snow during the month. August should start off like July though a wetter period of weather will return with moisture-laden fronts and troughs delivering good widespread moderate falls to the state with average or above average falls likely everywhere in NSW. A few good falls of snow will occur earlier in the month. September & October September will be dry in northern NSW and a little wet in southern NSW, with nice falls of snow after patchy and sporadic falls of snow in the mid-season. As September ends we should see the first mild outbreak of thunderstorms in NSW with most places likely to receive a thunderstorm by months end. October will be very warm (a little above average but nothing overly extreme) and humid, often the two will combine with the right ingredients and bring some nice strong outbreaks of storms across NSW with plenty of potential for severe storms, with average falls likely across most of the state (except SE NSW, where below average rainfall is likely). November & December November should be wet on the ranges due to a number of days with low wind shear. The west will receive alot of storms too, though wind shear should be a lesser problem. The coast is likely to receive a below average amount of thunderstorm activity but this will be compensated by a few onshore shower events and a heavy rain event (probably associated with a trough producing storms in western parts of the state with moist onshore winds producing heavy showers/rain on the coast, a situation that is probably not too dissimilar to the event that occured as we started this year). December will be a mixed bag of hot, cold, stormy, wet, and dry weather. We may see quite a number of "perfect" setups for thunderstorm activity but moisture is likely to be a problem especially before the strong fronts/troughs with the weaker ones likely to have the moisture available and so activity may not be overly severe at first during the month, though two or three severe outbreaks are likely mainly later in the month. There will be below average to above average falls (with these occuring haphazardly, so some areas near each other will receive vastly different monthly totals).


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