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A report from New York Fashion (Spring 2015) week found that while 79.69% of models on the runway were white, only 9.75% of models were black, 7.67% were Asian, and 2.12% were Latina. The lack of diversity also accounts for not only designers but models too, out of four hundred and seventy members of The Council of Fashion Designers of America (CFDA) only twelve of the members are black.[90] From the same study on New York Fashion Week, it was shown that only 2.7% of the 260 designers presented were black men, and an even smaller percentage were black female designers.[90] Even the relationship between independent designers and retailers can show the racial gap, only 1% of designers stocked at department stores being people of color. It was also found that in editorial spreads, over eighty percent of models pictured were white and only nine percent were black models. These numbers have stayed stagnant over the past few years.[90]
In the 16th century, national differences were at their most pronounced. Ten 16th century portraits of German or Italian gentlemen may show ten entirely different hats. Albrecht Dürer illustrated the differences in his actual (or composite) contrast of Nuremberg and Venetian fashions at the close of the 15th century (illustration, right). The "Spanish style" of the late 16th century began the move back to synchronicity among upper-class Europeans, and after a struggle in the mid-17th century, French styles decisively took over leadership, a process completed in the 18th century.[19]
Though different textile colors and patterns changed from year to year,[20] the cut of a gentleman's coat and the length of his waistcoat, or the pattern to which a lady's dress was cut, changed more slowly. Men's fashions were largely derived from military models, and changes in a European male silhouette were galvanized in theaters of European war where gentleman officers had opportunities to make notes of foreign styles such as the "Steinkirk" cravat or necktie.
Hopefully we have given you some creative new fashion blog post ideas. What are some of your go-to ideas for blog posts as a fashion and style blogger? Which one of these are your favourite fashion blog ideas? Share it with us in the comment section! If you're in need of some more sartorial inspiration, check out our post on fashion influencers to follow for SS18.
Many fashion designers have come under fire over the years for what is known as tokenism. Designer or editors will add one or two members on an underrepresented group to help them appear as inclusive and diverse, and to also help them give the illusion that they have equality.[89] This idea of tokenism helps designers avoid accusations of racism, sexism, body shaming, etc.[89]
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Additionally, there is a long history of fashion in West Africa.[11] Cloth was used as a form of currency in trade with the Portuguese and Dutch as early as the 16th Century.[11] Locally produced cloth and cheaper European imports were assembled into new styles to accommodate the growing elite class of West Africans and resident gold and slave traders.[11] There was an especially strong tradition of cloth-weaving in Oyo and the areas inhabited by the Igbo people.[11]
Great Post, I chose to focus on the crowdfunding niche. It was a 2 billion dollar industry last year and is projected to be a 5 billion dollar industry this year. I recommend using Fiverr to use graphic designers for first time bloggers. I did use the logo designed for five dollars at the top of my site (bottom now) but stopped using it because it didn't look good on mobile.
Accordingly, for the last three years-- ever since he had superintended the building of the new barn--Adam had always been made welcome at the Hall Farm, especially of a winter evening, when the whole family, in patriarchal fashion, master and mistress, children and servants, were assembled in that glorious kitchen, at well-graduated distances from the blazing fire.
fashion, style, and fad mean the way that up-to-date people do things. fashion is used of any custom (as a way of dressing or behaving) that is widely accepted at any one time or place. It was once the fashion for everyone to wear hats. style may suggest a fashion that is approved of by people with taste. The house was decorated in the latest style. fad is used for something that is very popular and often only for a short time. Beach tennis may be just a fad.


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Criticisms of Osho here are off the mark…the whole debate is a hopeless muddle. I have read all these critiques, and will cite them again as I move away from Osho land: Osho needs a break from these caviling critics. The correct critique is needed.
My perspective is to wonder how a larger but concealed Indian initiative to create a neo-buddshist contribution to global culture could have derailed so badly. I have attempted one answer in a previous post. But I think Osho was betrayed, and one factor was the contempt that arises from peddling shoddy goods for the overseas masses.
The critic here has Osho's enlightenment, and the concept in general, completely muddled.
One problem is that an enlightened person can surrender will, become enlightened, and then become compulsive and this can also be the result of enemies trying to destroy you by surrogating your 'will' slot in the unconscious. Did this happen to Osho?
I think that I have contacted to try and help (most won't believe that), and the whole game of Osho is desperate at this point. I can't do anything here because the cloud of enemies attacks everyone trying to intervene.
The occult world is deadly: it is almost impossible to have a spiritual path with people like EJ Gold around (they can't deal however with more than a few victims).
Perhaps this is why sufis don't speak of enlightenment. There are too many sufi apes like Gold and other occultists who can penetrate the 'enlightenment' defense. But a balanced development of will and consciousness is almost a non-path…Vultures like Gurdjieff will attack attempts to move here. That means a still more opaque sufi realm, not on your side, is a danger to you if they ever learn of your existence…
I don't think it is correct to say 'enlightenment' is something you channel…
Enlightenment is not something you own; it is something you channel.
Whatever term you use for the phenomenon of enlightenment, it is scientifically accurate to say that no human being has any power of their own. Even the chemical energy of our metabolism is borrowed from the Sun, which beams light to the Earth, which is then converted by plants through photosynthesis into the food we eat. You may get your bread from the supermarket, but the caloric energy it contains originated from the thermonuclear reactions of a nearby star. Our physical bodies run on star power. Any "spiritual" energy we channel also comes from far beyond, from all sides of the universe, from the complete TES (Time-Energy-Space), from beyond the oceans of galaxies, and onto infinity. No human being owns the Atman, and no one can speak for the TES.
The Void has no ambition or personality whatsoever, so Rajneesh could only speak for his own animal mind. The animal mind may want its disciples to "take over the whole world," but the Void does not care because it is beyond any motivation. The phenomena we called Rajneesh, Bhagwan, and Osho, was only a temporary lens of cosmic energy, not the full cosmos itself.
Rajneesh and the famous Greek-Armenian mystic, George Gurdjieff, often used the power of the Atman for clearly personal gain. Both men used their cosmic consciousness to overwhelm and seduce women. Gurdjieff was ashamed of his behavior and vowed many times during his life to end this practice, which was a combination of ordinary male lust backed up by the potent advantage of oceanic super-mental power. Rajneesh went even further and used his channeled cosmic energy to manipulate masses of people to gain a kind of quasi-political status, and to aggrandize himself far beyond what was honest and helpful to his disciples. In Oregon, Rajneesh declared to the media that "My religion is the only religion!" Diplomacy and modesty were not his strong points.
To my knowledge, George Gurdjieff never reached the extremes of self-indulgence of Rajneesh, and he even warned his disciples not to have blind faith in him. Gurdjieff wanted his students to be free and independent, with the combined abilities of clear mental reasoning and cosmic consciousness. Rajneesh, by contrast, seemed to believe that only his thoughts and ideas were of value because only he was "enlightened." This was a grand error in judgment and revealed a basic flaw in his character. Unfortunately, when Rajneesh achieved the ability to fully channel the power of the Atman, he failed to apply the needed wisdom of self-restraint. His human mind so rebelled against Asian asceticism that he failed to ensure that his borrowed power was only used for the good of others. Rajneesh was driven by strong personal ambitions, not just compassion.

subset: commoncrawl


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Thanks to Brexit, Ryanair is Selling Tickets For Flights that may not Fly
Ryanair continued its worst-case scenario Brexit preparations this week, announcing that it will include a "Brexit clause" in flight bookings scheduled for summer 2019. Translation? Customers' tickets may not be valid if the UK and EU don't reach an alternative aviation deal before then.
Unlike other industries, which can rely on existing World Trade Organization rules after Brexit, the UK's aviation industry has no fallback option when the Open Skies Agreement that currently allows EU airlines to fly freely within the bloc ceases to apply to Britain. The UK is scheduled to leave the EU in March 2019, and Ryanair is preparing for the event—hopefully avoidable—where flights between the UK and EU are grounded in absence of a deal.
The move comes after Ireland-based Ryanair applied to set up a UK subsidiary in December, which will allow it to operate its intra-UK routes as a domestic airline if a deal isn't met. While industry watchers say it's unlikely the EU and UK will fail to find an interim solution—both sides have a lot to lose—Ryanair is not taking any chances. The airline will release its summer 2019 schedule in September of this year and, for now, it has said customers will be refunded if their flights are cancelled under the so-called Brexit clause.
"We don't see a regulatory solution yet," said Ryanair marketing chief Kenny Jacobs. "If in the meantime between now and September, there's a regulatory solution found, then those tickets will be sold as normal."
Until then, sun-starved Brits will book their summer tickets with fingers firmly crossed./QUARTZ
- » Croatian Airlines to Operate Flights to Sofia and Podgorica
- » Bulgaria Air Launches Direct Flights to Valencia
- » NSI: Total Number of Accommodation Establishments in Bulgaria Increased by 1.4%
- » Flights from Sofia to Munich and Dusseldorf Cancelled due to Storm Ciara
- » Turkish Airlines Will Start Operating Flights to Equatorial Guinea
- » Turkey is Catching up with Spain on Tourism Revenue


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text: My team, MyCork Polish Association, is going to play in the Business League this year and we are looking for a pitch to rent. We are looking for something in the city or near to the city. Is there any team who has a pitch and might be interested to share it with us? My name is Jack and the number is 0851532057.


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Pope to visit Latin America despite ill health
Pope John Paul II is to go ahead with a tour of Latin America and Canada in the coming months despite concerns over his poor health.
"The pontiff has personally approved the schedule which is now set. No-one has told the organisers that these visits could be cancelled," a Vatican spokesman said today.
The Pope is due to visit Canada in late July before travelling to Mexico and Guatemala.
Speculation the trip could be cancelled rose yesterday when a spokesman suggested that although the Canada trip was confirmed, the Latin American visit could be cancelled.
The spokesman later said there was no change to the planned travel schedule.


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Games4King Cute Peacock Rescue
Games4King - G4K Cute Peacock Rescue Escape is another point and click escape game developed by Games 4 King. There was a small village in a beautiful magnificent forest. The village was very beautiful to see. There was a peacock in that forest. The peacock was unexpectedly stuck in a wooden house with the villagers. It is your duty to save the peacock from there. It will help you to find the hidden clues where the peacock can be saved from there. Find all the clues and save that peacock from there and congratulate you to win the game. The tricks of the trick are a little harder to find, but somehow it may be a matter of interest. Good luck and have fun!
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Four films about exemplar, unique projects by our practice demonstrate why these key sectors will transform the way we live, work and learn.
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E-wedding card
Budget ₹600-1500 INR
I want to get an e-wedding card design done.
23 freelancers are bidding on average ₹1219 for this job
➽➽➽Greetings! Hello.....I will provide you BUSINESS CARD DESIGN with editable format(2 Option In 24hrs) with unlimited revision on selected designs.➽➽➽ Thanks for reading my proposal. I've noted down the requirements More
Hi There, I am creative Flyer Designer with 7 years professional experience. I will prepare Flyer designs in the best quality within the desired time frame. You will get unlimited revisions and more concepts if needed More
HI I like to create your graphics like logo,flyer,brochure,company profile, photo edits and any king of graphics with the way you imagine and what you like, making it so modern and professional , I have the experience More
hello, Thank you for taking the time . I am really thankful to work on your project. I believe in ORIGINAL and QUALITY work since Work is my solo identity. work delivery on time . **UNLIMITED REVISIONS** ★File Forma More
My Key Skills are Flyer Design , Banner Design , Invitation Design , CAD ,Power Point and MS Office.
Hi, I just read your Graphic Design project description. I have well experience in this field of 5+ years.I will give you first draft with in few hours. The design provided will be creative and according to your requir More
hello how are you? I can read Your project detail regard WEDDING CARD DESIGN I CAN DO IT ASAP that you have been posted.i have good experience in all kind of graphic.i will give you 100% quality [login to view URL] we can work More
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Hi I can design an amazing wedding e-card for you in 1 day. You can also choose a design from freepik.com. I have subscription of this website so I can modify your chosen design for you.
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Energizer ® Max – AA.Long lasting energy with NO Leaks Guaranteed. Designed to protect your devices against damaging leaks. Dependable energy for your everyday devices. Rhode Island spends over $3 billion every year on out-of-state fossil fuels. Investing in renewable energy, energy efficiency, and resiliency puts this money to work in our state, employing Rhode Islanders and creating jobs across the economy: from building trades, health care, and retail to the green energy economy.Strong climate action will support the clean energy industry--one of the. ENERGIZER ® VISION HD FOCUS HEADLIGHT Unbeatable performance with a patented digital focus and maximum brightness of 250 lumens Small in size, big in performance Long lasting, and reliable energy for all your device needs. Jan 15, 2011 · This item: Energizers! 88 Quick Movement Activities That Refresh and Refocus, K-6 by Susan Lattanzi Roser Spiral-bound $20.69 In Stock. Ships from and sold by. Energizer Batteries EN22 9V Industrial Alkaline Battery w/ Cap Protectors - Malaysia, 12-2024 Exp.
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Background: Irisin, a novel exercise-induced myokine, was shown to mediate beneficial effects of exercise in osteoporosis. Microgravity is a major threat to bone homeostasis of astronauts during long-term spaceflight, which results in decreased bone formation. Methods: The hind-limb unloading mice model and a random position machine are respectively used to simulate microgravity in vivo and in vitro. Results: We demonstrate that not only are bone formation and osteoblast differentiation decreased, but the expression of fibronectin type III domain-containing 5 (Fdnc5; irisin precursor) is also downregulated under simulated microgravity. Moreover, a lower dose of recombinant irisin (r-irisin) (1 nM) promotes osteogenic marker gene (alkaline phosphatase (Alp), collagen type 1 alpha-1(ColIα1)) expressions, ALP activity, and calcium deposition in primary osteoblasts, with no significant effect on osteoblast proliferation. Furthermore, r-irisin could recover the decrease in osteoblast differentiation induced by simulated microgravity. We also find that r-irisin increases ß-catenin expression and partly neutralizes the decrease in ß-catenin expression induced by simulated microgravity. In addition, ß-catenin overexpression could also in part attenuate osteoblast differentiation reduction induced by simulated microgravity. Conclusions: The present study is the first to show that r-irisin positively regulates osteoblast differentiation under simulated microgravity through increasing ß-catenin expression, which may reveal a novel mechanism, and it provides a prevention strategy for bone loss and muscle atrophy induced by microgravity.
OBJECTIVES: We employed a comprehensive systematic review and meta-analysis to assess benefits and risks of a threshold of haemoglobin level below 7 g/dL versus liberal transfusion strategy among critically ill patients, and even patients with septic shock. DESIGN: Systematic review and meta-analysis. DATA SOURCES: We performed systematical searches for relevant randomised controlled trials (RCTs) in the Cochrane Library, EMBASE and PubMed databases up to 1 September 2019. ELIGIBILITY CRITERIA: RCTs among adult intensive care unit (ICU) patients comparing 7 g/dL as restrictive strategy with liberal transfusion were incorporated. DATA EXTRACTION AND SYNTHESIS: The clinical outcomes, including short-term mortality, length of hospital stay, length of ICU stay, myocardial infarction (MI) and ischaemic events, were screened and analysed after data collection. We applied odds ratios (ORs) to analyse dichotomous outcomes and standardised mean differences (SMDs) to analyse continuous outcomes with fixed or random effects models based on heterogeneity evaluation for each outcome. RESULTS: Eight RCTs with 3415 patients were included. Compared with a more liberal threshold, a red blood cell (RBC) transfusion threshold <7 g/dL haemoglobin showed no significant difference in short-term mortality (OR: 0.90, 95% CI: 0.67 to 1.21, p=0.48, I2=53%), length of hospital stay (SMD: -0.11, 95% CI: -0.30 to 0.07, p=0.24, I2=71%), length of ICU stay (SMD: -0.03, 95% CI: -0.14 to 0.08, p=0.54, I2=0%) or ischaemic events (OR: 0.80, 95% CI: 0.43 to 1.48, p=0.48, I2=51%). However, we found that the incidence of MI (OR: 0.54, 95% CI: 0.30 to 0.98, p=0.04, I2=0%) was lower in the group with the threshold <7 g/dL than that with the more liberal threshold. CONCLUSIONS: An RBC transfusion threshold <7 g/dL haemoglobin is incapable of decreasing short-term mortality in ICU patients according to currently published evidences, while it might have potential role in reducing MI incidence.
BACKGROUND: Luman is a member of CREB3 (cAMP responsive element-binding) subfamily of the basic leucine-zipper (bZIP) transcription factors. It may play an important regulatory role during the decidualization process since Luman was highly expressed in the decidual cells. However, the exact molecular mechanisms of how Luman regulating decidualization is unknown. RESULTS: Using an in vitro model, we prove that Luman knockdown significantly affects the decidualization process of mice endometrial stromal cells (ESCs) as the expression of two decidual markers PRL8a2 and PRL3c1 were repressed. We employed massively parallel RNA sequencing (RNA-Seq) to understand the changes in the transcriptional landscape associated with knockdown of Luman in ESCs during in vitro decidualization. We found significant dysregulation of genes related to protein processing in the endoplasmic reticulum (ER). Several genes involved in decidualization including bone morphogenetic proteins (e.g. BMP1, BMP4, BMP8A, BMP2, and BMP8B), growth factor-related genes (e.g. VEGFB, FGF10, and FGFR2), and transcription factors (IF4E, IF4A2, WNT4, WNT9A, ETS1, NOTCH1, IRX1, IDB1, IDB2, and IDB3), show altered expression. We also found that the knockdown of Luman is associated with increased expression of cell cycle-related genes including cycA1, cycB1, cycB2, CDK1, CDK2, and PLPK1, which resulted in an increased proportion of ESCs in the G1 phase. Differentially expressed genes (DEGs) were highly enriched on ECM-receptor interaction signaling, endoplasmic reticulum protein processing, focal adhesion, and PI3K-Akt signaling pathways. CONCLUSIONS: Luman knockdown results in widespread gene dysregulation during decidualization of ESCs. Genes involved in protein processing in ER, bone morphogenetic protein, growth factor, and cell cycle progression were identified as particularly important for explaining the decidual deficiency observed in this in vitro model. Therefore, this study provides clues as to the underlying mechanisms that may expand our understanding of gene regulation during decidualization.
The one-stage partial nitritation-anammox (PN-A) process is considered an efficient process for low-cost nitrogen removal. In this study, the nitrogen removal performance of different-sized granules in a one-stage PN-A reactor was studied. The total autotrophic nitrogen removal rate (TANRR) of the granular sludge increased as the granule size increased, and the TANRR of granular sludge with a radius larger than 500 µm reached 0.14 kgN kgVSS-1 d-1. High-throughput sequencing revealed that the abundance of ammonium-oxidizing bacteria and anaerobic ammonium-oxidizing (anammox) bacteria in granular sludge of different sizes differed, indicating that the bacterial community structure was affected by the granule size. The TANRR of different-sized granules was affected by the volumes of aerobic micro-zone and anaerobic micro-zone inside the granule. Appropriate micro-zone volumes inside the granules could be regulated by the dissolved oxygen (DO) concentration of the reactor, which are favourable for achieving a balance between partial nitritation and anammox and then satisfactory nitrogen removal. Small-volume variations in the range of micro-zones have a significant influence on the balance between partial nitritation and anammox. The proper DO concentration required for different-sized granules to achieve better nitrogen removal differed. This study provides a novel perspective for understanding the effect of micro-zones of granular sludge on one-stage PN-A nitrogen removal.
The structural integrity and functional stability of organelles are prerequisites for the viability and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the pathogenesis and progression of various diseases, such as chronic obstructive pulmonary disease, cardiovascular diseases, infection, and neurodegenerative diseases. In fact, those organelles synchronously present with evident structural derangement and aberrant function under exposure to different stimuli, which might accelerate the corruption of cells. Therefore, the quality control of multiple organelles is of great importance in maintaining the survival and function of cells and could be a potential therapeutic target for human diseases. Organelle-specific autophagy is one of the major subtypes of autophagy, selectively targeting different organelles for quality control. This type of autophagy includes mitophagy, pexophagy, reticulophagy (endoplasmic reticulum), ribophagy, lysophagy, and nucleophagy. These kinds of organelle-specific autophagy are reported to be beneficial for inflammatory disorders by eliminating damaged organelles and maintaining homeostasis. In this review, we summarized the recent findings and mechanisms covering different kinds of organelle-specific autophagy, as well as their involvement in various diseases, aiming to arouse concern about the significance of the quality control of multiple organelles in the treatment of inflammatory diseases.Abbreviations: ABCD3: ATP binding cassette subfamily D member 3; AD: Alzheimer disease; ALS: amyotrophic lateral sclerosis; AMBRA1: autophagy and beclin 1 regulator 1; AMPK: AMP-activated protein kinase; ARIH1: ariadne RBR E3 ubiquitin protein ligase 1; ATF: activating transcription factor; ATG: autophagy related; ATM: ATM serine/threonine kinase; BCL2: BCL2 apoptosis regulator; BCL2L11/BIM: BCL2 like 11; BCL2L13: BCL2 like 13; BECN1: beclin 1; BNIP3: BCL2 interacting protein 3; BNIP3L/NIX: BCL2 interacting protein 3 like; CALCOCO2/NDP52: calcium binding and coiled-coil domain 2; CANX: calnexin; CAT: catalase; CCPG1: cell cycle progression 1; CHDH: choline dehydrogenase; COPD: chronic obstructive pulmonary disease; CSE: cigarette smoke exposure; CTSD: cathepsin D; DDIT3/CHOP: DNA-damage inducible transcript 3; DISC1: DISC1 scaffold protein; DNM1L/DRP1: dynamin 1 like; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; EIF2S1/eIF2α: eukaryotic translation initiation factor 2 alpha kinase 3; EMD: emerin; EPAS1/HIF-2α: endothelial PAS domain protein 1; ER: endoplasmic reticulum; ERAD: ER-associated degradation; ERN1/IRE1α: endoplasmic reticulum to nucleus signaling 1; FBXO27: F-box protein 27; FKBP8: FKBP prolyl isomerase 8; FTD: frontotemporal dementia; FUNDC1: FUN14 domain containing 1; G3BP1: G3BP stress granule assembly factor 1; GBA: glucocerebrosidase beta; HIF1A/HIF1: hypoxia inducible factor 1 subunit alpha; IMM: inner mitochondrial membrane; LCLAT1/ALCAT1: lysocardiolipin acyltransferase 1; LGALS3/Gal3: galectin 3; LIR: LC3-interacting region; LMNA: lamin A/C; LMNB1: lamin B1; LPS: lipopolysaccharide; MAPK8/JNK: mitogen-activated protein kinase 8; MAMs: mitochondria-associated membranes; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MFN1: mitofusin 1; MOD: multiple organelles dysfunction; MTPAP: mitochondrial poly(A) polymerase; MUL1: mitochondrial E3 ubiquitin protein ligase 1; NBR1: NBR1 autophagy cargo receptor; NLRP3: NLR family pyrin domain containing 3; NUFIP1: nuclear FMR1 interacting protein 1; OMM: outer mitochondrial membrane; OPTN: optineurin; PD: Parkinson disease; PARL: presenilin associated rhomboid like; PEX3: peroxisomal biogenesis factor 3; PGAM5: PGAM family member 5; PHB2: prohibitin 2; PINK1: PTEN induced putative kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; RB1CC1/FIP200: RB1 inducible coiled-coil 1; RETREG1/FAM134B: reticulophagy regulator 1; RHOT1/MIRO1: ras homolog family member T1; RIPK3/RIP3: receptor interacting serine/threonine kinase 3; ROS: reactive oxygen species; RTN3: reticulon 3; SEC62: SEC62 homolog, preprotein translocation factor; SESN2: sestrin2; SIAH1: siah E3 ubiquitin protein ligase 1; SNCA: synuclein alpha; SNCAIP: synuclein alpha interacting protein; SQSTM1/p62: sequestosome 1; STING1: stimulator of interferon response cGAMP interactor 1; TAX1BP1: Tax1 binding protein 1; TBK1: TANK binding kinase 1; TFEB: transcription factor EB; TICAM1/TRIF: toll-like receptor adaptor molecule 1; TIMM23: translocase of inner mitochondrial membrane 23; TNKS: tankyrase; TOMM: translocase of the outer mitochondrial membrane; TRIM: tripartite motif containing; UCP2: uncoupling protein 2; ULK1: unc-51 like autophagy activating kinase; UPR: unfolded protein response; USP10: ubiquitin specific peptidase 10; VCP/p97: valosin containing protein; VDAC: voltage dependent anion channels; XIAP: X-linked inhibitor of apoptosis; ZNHIT3: zinc finger HIT-type containing 3.
Stellera chamaejasme is one of the most serious weeds in Qinhai-Tibetan Plateau, the rapid expansion of which exerts an increasing effect on the alpine meadow ecosystem. With high-throughput sequencing technology, geostatistics and GIS method, the spatial heterogeneity of soil fungal diversity in Stellera occurrence area and the spatial correlation between Stellera coverage and soil fungal diversity were investigated in a typical degraded alpine meadow of the Qilian Mountain. Compared to no-Stellera area, the fungi richness in Stellera area decreased, the dominance increased, and the α-diversity reduced. The difference of fungal species composition enhanced and ß-diversity significantly increased. The spatial pattern of soil fungal diversity was affected by the invasion of Stellera, resulting in higher fragmentation in occurrence area. Spatial heterogeneity of species composition increased remarkably, and spatial stability of α-diversity and ß-diversity decreased. The portion of positive correlation and negative correlation interlaced, indicating no clear spatial correlation between Stellera coverage and soil fungal diversity. Our results indicate that the spatial pattern of soil fungal diversity was affected by the interaction of soil and vegetation in Stellera invaded meadows.
AssuntosSolo , Thymelaeaceae , Ecossistema , Fungos , Pradaria , Microbiologia do Solo
PURPOSE: To assess the potential for CUE-101, a novel therapeutic fusion protein, to selectively activate and expand HPV16 E711-20-specific CD8+T cells as an off-the shelf therapy for the treatment of HPV16-driven tumors, including head and neck squamous cell carcinoma (HNSCC), cervical and anal cancers. EXPERIMENTAL DESIGN: CUE-101 is an Fc fusion protein comprised of a human leukocyte antigen (HLA) complex, an HPV16 E7 peptide epitope, reduced affinity human interleukin-2 (IL-2) molecules, and an effector attenuated human immunoglobulin G (IgG1) Fc domain. Human E7-specific T cells and human peripheral blood mononuclear cells (PBMC) were tested to demonstrate cellular activity and specificity of CUE-101, while in vivo activity of CUE-101 was assessed in HLA-A2 transgenic mice. Anti-tumor efficacy with a murine surrogate (mCUE-101) was tested in the TC-1 syngeneic tumor model. RESULTS: CUE-101 demonstrates selective binding, activation, and expansion of HPV16 E711-20-specific CD8+T cells from PBMCs relative to non-target cells. Intravenous administration of CUE-101 induced selective expansion of HPV16 E711-20-specific CD8+T cells in HLA-A2 (AAD) transgenic mice, and anti-cancer efficacy and immunologic memory was demonstrated in TC-1 tumor bearing mice treated with mCUE-101. Combination therapy with anti-PD-1 checkpoint blockade further enhanced the observed efficacy. CONCLUSIONS: Consistent with its design, CUE-101 demonstrates selective expansion of an HPV16 E711-20-specific population of cytotoxic CD8+T cells, a favorable safety profile, and in vitro and in vivo evidence supporting its potential for clinical efficacy in an ongoing Phase 1 trial (NCT03978689).
A novel online two-dimensional supercritical fluid chromatography/reversed-phase liquid chromatography-triple-quadrupole mass spectrometry (2D SFC/RPLC-QQQ MS) method based on a vacuum solvent evaporation interface was developed for lipid profiling in human plasma, in which lipid classes were separated by the first-dimension SFC and different lipid molecular species were further separated by the second-dimension RPLC. All separation condition parameters were carefully optimized, and their influence on the chromatographic behavior of lipids is discussed. Finally, the recoveries of 11 lipid standards were all more than 88% for the interface. Besides, the limit of detection for these lipid standards was on the order of nanograms per milliliter, and the relative standard deviations of the peak area and retention time ranged from 1.54% to 19.85% and from 0.00% to 0.10%, respectively. The final 2D SFC/RPLC-QQQ MS method allowed the identification of 370 endogenous lipid species from ten lipid classes, including diacylglycerol, triacylglycerol, ceramide, glucosylceramide, galactosylceramide, lactosylceramide, sphingomyelin, acylcarnitine, phosphatidylcholine, and lysophosphatidylethanolamine, in human plasma within 38 min, which was used for screening potential lipid biomarkers in breast cancer. The 2D SFC/RPLC-QQQ MS method is a potentially useful tool for in-depth studies focused on complex lipid metabolism and biomarker discovery. Graphical Abstract.
Introduction: Sepsis is an intractable disorder, which is associated with high risk of organ dysfunction and even death, while its pathogenesis remains largely unclear. Our study aims to study the research trend on sepsis and host immune response, and compare the contribution of publications from different countries, institutions, journals and authors. Materials and Methods: We extracted all relevant publications with regard to sepsis and immune response during 1999-2019 from Web of Science. GraphPad Prism 6, and VOSviewer software were used to collect and analyze the publication trend in related field. Results: We identified a total of 1225 publications with citation frequency of 40511 times up to March 30, 2019. The United States accounted for the largest number of publications (36.3%), 51.9% of total citations as well as the highest H-index (72). The sum of publications from China ranked the second, while the overall citations (1935) and H-index (22) ranked the eighth and the seventh, respectively. Journal of Shock had published most papers related to the topic on sepsis and immune response. Ayala A SA, has published the most papers in this field (31), while Hotchkiss RS presented with the most citation frequency (3532). The keyword "regulatory T cell" appeared most recently with an average appearing years of 2014.0. The "immunosuppression related research" seemed to be the hotspot in relevant scope. Conclusions: The United States made the most outstanding contribution within this important field. There is a mismatch between the quantity and quality of publications from China. Latest progress can be tracked in journal of Shock. Immunosuppression related researches may be hotspots in the near future.
Microtubule actin cross-linking factor 1 (Macf1) is a spectraplakin family member known to regulate cytoskeletal dynamics, cell migration, neuronal growth and cell signal transduction. We previously demonstrated that knockdown of Macf1 inhibited the differentiation of MC3T3-E1 cell line. However, whether Macf1 could regulate bone formation in vivo is unclear. To study the function and mechanism of Macf1 in bone formation and osteogenic differentiation, we established osteoblast-specific Osterix (Osx) promoter-driven Macf1 conditional knockout mice (Macf1f/f Osx-Cre). The Macf1f/f Osx-Cre mice displayed delayed ossification and decreased bone mass. Morphological and mechanical studies showed deteriorated trabecular microarchitecture and impaired biomechanical strength of femur in Macf1f/f Osx-Cre mice. In addition, the differentiation of primary osteoblasts isolated from calvaria was inhibited in Macf1f/f Osx-Cre mice. Deficiency of Macf1 in primary osteoblasts inhibited the expression of osteogenic marker genes (Col1, Runx2 and Alp) and the number of mineralized nodules. Furthermore, deficiency of Macf1 attenuated Bmp2/Smad/Runx2 signalling in primary osteoblasts of Macf1f/f Osx-Cre mice. Together, these results indicated that Macf1 plays a significant role in bone formation and osteoblast differentiation by regulating Bmp2/Smad/Runx2 pathway, suggesting that Macf1 might be a therapeutic target for bone disease.
BACKGROUND: Bone is an important tissue and its normal function requires tight coordination of transcriptional networks and signaling pathways, and many of these networks/ pathways are dysregulated in pathological conditions affecting cartilage and bones. Long non-coding RNA (lncRNA) refers to a class of RNAs with a length of more than 200 nucleotides, lack of protein-coding potential, and exhibiting a wide range of biological functions. Although studies on lcnRNAs are still in their infancy, they have emerged as critical players in bone biology and bone diseases. The functions and exact mechanism of bone-related lncRNAs have not been fully classified yet. OBJECTIVE: The objective of this article is to summarize the current literature on lncRNAs on the basis of their role in bone biology and diseases, focusing on their emerging molecular mechanism, pathological implications and therapeutic potential. DISCUSSION: A number of lncRNAs have been identified and shown to play important roles in multiple bone cells and bone disease. The function and mechanism of bone-related lncRNA remain to be elucidated. CONCLUSION: At present, majority of knowledge is limited to cellular levels and less is known on how lncRNAs could potentially control the development and homeostasis of bone. In the present review, we highlight some lncRNAs in the field of bone biology and bone disease. We also delineate some lncRNAs that might have deep impacts on understanding bone diseases and providing new therapeutic strategies to treat these diseases.
INTRODUCTION: Blast injuries are complex types of physical trauma resulting from direct or indirect exposure to an explosion, which can be divided into four classes: primary, secondary, tertiary, and quaternary. Primary blast injury results in damage, principally, in gas-containing organs such as the lungs (blast lung injury, BLI). BLI is defined as radiological and clinical evidence of acute lung injury occurring within 12h of exposure to an explosion and not due to secondary or tertiary injury. BLI often combines with cutaneous thermal injury, a type of quaternary blast injury, either in terrorist bomb attacks or in civilian accidental explosions. This report summarizes our experience in the management of combined massive burn and BLI at a Shanghai Burn Center in China. METHODS: A retrospective observational analysis of clinical data was performed for massive burn patients with or without BLI during a 20-year interval. Patient characteristics, causes of injury, clinical parameters, management, and outcomes were recorded and evaluated. RESULTS: A total of 151 patients (120 males and 31 females) with severe burn injury (≥50% TBSA) treated at the Burn Center of Changhai Hospital in Shanghai between July 1997 and June 2017 were enrolled in this study. Their mean age was 38.6±17.8 (3-75) years. Among them, 28 patients had combined BLI and burn injury and 39 patients had no BLI or smoke inhalation injury (non-BLI-SII). No significant difference was observed in the burn area or full-thickness burn area between the two groups. The lowest PaO2/fraction of inspired oxygen (FiO2) ratio during the first 24h in BLI patients was significantly lower than that in non-BLI-SII patients. Exudative changes were observed by X-ray radiography in all BLI patients but not in non-BLI-SII patients within 6h after injury. A significantly higher proportion of colloids were used for fluid resuscitation in BLI patients than that in non-BLI-SII patients. A higher proportion and longer time of mechanical ventilation were needed for BLI patients than those for non-BLI-SII patients, and a higher proportion of patients received sedative agents in the BLI group than those in the non-BLI-SII group. The first escharectomy was performed relatively later in BLI patients than in non-BLI-SII patients because of more time taken by BLI patients to recover from lung injury. The length of ICU and hospital stay in BLI patients was significantly longer than that in non-BLI-SII patients. No significant difference in the overall mortality was detected between these two groups. CONCLUSION: It is a formidable challenge for clinicians to diagnose and manage massive burn patients combined with BLI. A comprehensive treatment approach is strongly recommended, including fluid resuscitation, airway management, mechanical ventilation, and surgical treatment. Given the high mortality of massive burn patients combined with BLI even in a recognized burn center, more prospective studies are encouraged to assess more effective strategies for the treatment of such patients.
PURPOSE: The study was performed to estimate the diagnostic blood loss (DBL) volume during hospitalization and investigate its relationship with the development of moderate to severe hospital acquired anemia (HAA) and increased number of red blood cell (RBC) transfusion following extensive burns. MATERIALS AND METHODS: This was a retrospective study of adult burned patients with total body surface area (TBSA) burn larger than 40%, who were admitted to burn center of Changhai hospital between January 2005 and December 2017. RESULTS: We included a final number of 157 patients in the present study. Moderate to severe HAA within the fourth week postburn was developed in 46 of 121 patients who stayed over 28-day hospitalization. Patients with moderate to severe HAA had both significantly higher total DBL volume [245 (IQR: 183.75, 325.25) mL vs 168 (119, 163) mL ; P = 0.001] and DBL volume per day [10.22 (IQR: 8.57, 12.38) mL vs 6.63 (5.22, 10.42) mL/day; P = 0.005]. Logistic regression analysis revealed that both DBL volume per day and TBSA burn were independent risk factors for the development of moderate to severe HAA. CONCLUSIONS: Severely burned patients appear to be prone to develop HAA during hospitalization. The DBL volume contribute to the occurrence of moderate to severe HAA, which might be a modifiable target for preventing HAA.
Acinetobacter baumannii is a frequent cause of the nosocomial infections. Herein, a novel isothermal amplification technique, multiple cross displacement amplification (MCDA) is employed for detecting all A. baumannii strains and identifying the strains harboring blaOXA-23-like gene. The duplex MCDA assay, which targets the pgaD and blaOXA-23-like genes, could identify the A. baumannii isolates and differentiate these isolates harboring blaOXA-23-like gene. The disposable lateral flow biosensors (LFB) were used for analyzing the MCDA products. A total of sixty-eight isolates, include fifty-three A. baumannii strains and fifteen non-A. baumannii strains, were employed to optimize MCDA methods and determine the sensitivity, specificity and feasibility. The optimal reaction condition is found to be 63 °C within 1 h, with limit of detection at 100 fg templates per tube for pgaD and blaOXA-23-like genes in pure cultures. The specificity of this assay is 100%. Moreover, the practical application of the duplex MCDA-LFB assay was evaluated using clinical samples, and the results obtained from duplex MCDA-LFB method were consistent with conventional culture-based technique. In sum, the duplex MCDA-LFB assay appears to be a reliable, rapid and specific technique to detect all A. baumannii strains and identify these strains harboring blaOXA-23-like gene for appropriate antibiotic therapy.
CONTEXT: Osteoporosis is a degenerative bone disease in aging men and women. MiRNAs associated with progressive bone loss in osteoporosis had not been clearly demonstrated. OBJECTIVE: Evaluation of the differentially expressed miRNAs in bone tissue and serum of osteoporotic women with aging. METHODS: MiRNAs GeneChip and real-time PCR were used to screen differently expressed miRNAs in bone tissues of 21 aged osteoporotic women at 60-69 years and 80-89 years. Identified miRNAs were detected in serum of validation cohort consisted of 14 healthy premenopausal women and 86 postmenopausal women with osteopenia or osteoporosis. MiR-181c-5p and miR-497-3p expression were validated in aging and OVX mice models, and osteoblasts. Their role in osteogenesis was validated in vitro. RESULTS: 24 miRNAs were found to be top differentially expressed in bone tissues of osteoporotic women in initial screening. 4 miRNAs were identified both in bone tissue and serum in the validation cohort. Among them, miR-181c-5p and miR-497-5p were decreased in the serum of postmenopausal women with osteopenia or osteoporosis, but increased in subjects treated with bisphosphonate plus calcitriol. MiR-181c-5p and miR-497-5p were significantly downregulated in bone tissue of aging and OVX mice models, and upregulated in osteogenic differentiation of hFOB1.19 and MC3T3-E1 cells. Overexpression of miR-181c-5p and miR-497-5p could promote the differentiation and mineralization of osteoblast. CONCLUSIONS: MiR-181c-5p and miR-497-5p are involved in bone metabolism and associated with progressive bone loss of osteoporosis, suggesting that circulating miR-181c-5p and miR-497-5p might act as potential biomarkers for monitoring effects of anti-osteoporosis therapies or diagnostic approach.
AIM: A high-risk strategy has been implemented for lipid-lowering therapy in the primary prevention of cardiovascular disease. However, atherosclerosis and cardiovascular events are common among individuals with low cardiovascular risk. This study aimed to determine whether the small dense low-density lipoprotein cholesterol (sdLDLC) level can predict carotid atherosclerosis progression and identify high-risk individuals. METHODS: Baseline sdLDLC and low-density lipoprotein cholesterol (LDLC) were measured in 808 participants from the Chinese Multi-provincial Cohort Study, aged 45-74 years. Adjusted relative risk was calculated using a modified Poisson regression model to assess the relationship between sdLDLC and 5-year atherosclerosis progression, as indicated by the progression, incidence, and multi-territorial extent of carotid plaque. RESULTS: The 5-year atherosclerosis progression increased significantly with increased sdLDLC. Baseline sdLDLC was significantly associated with the short-term risk of plaque progression after multivariable adjustment, even in participants with low LDLC or a 10-year estimated cardiovascular risk. sdLDLC predicted plaque progression (relative risk 2.05; 95% confidence interval 1.43-2.93) in participants with LDLC ï¼130 mg/dL. Furthermore, participants with the highest sdLDLC but intermediate or low cardiovascular risk (accounting for 16% of the cohort) had double the risk of plaque progression, which was comparable to those with the same sdLDLC and high cardiovascular risk, relative to those with the lowest sdLDLC levels and low cardiovascular risk. CONCLUSIONS: sdLDLC is independently associated with the progression of carotid atherosclerosis, which may provide a basis for clinicians to reclassify individuals believed to be at low cardiovascular risk into the high-risk category, and those with high sdLDLC may benefit from more aggressive cholesterol-lowering treatment.
Casein and chicken are assessed to contain high quality proteins, which are essential for human health. Studies have shown that ingestion of the two dietary proteins resulted in distinct effects on physiology, liver transcriptome and gut microbiota. However, its underlying mechanism is not fully understood, in particular for a crosstalk between gut microbiota and host under a specific diet intervention. We fed young rats with a casein or a chicken protein-based diet (CHPD) for 7 days, and characterized cecal microbiota composition and cecal gene expression. We found that a short-term intervention with a casein-based diet (CAD) induced a higher relative abundance of beneficial bacterium Lactococcus lactis as well as Bifidobacterium pseudolongum, which upregulated galactose metabolism of the microbiome compared with a CHPD. The CAD also upregulated gene expression involved in obesity associated pathways (e.g., Adipoq and Irs1) in cecal tissue of rats. These genes and the bacterial taxon were reported to play an important role in protecting development of obesity. Furthermore, the differentially represented bacterial taxon L. lactis was positively associated with these differentially expressed genes in the gut tissue. Our results provide a new insight into the crosstalk between gut microbiota and host in response to dietary proteins, indicating a potential mechanism of obesity prevention function by casein.
BACKGROUND: Flesh color is one of the most important traits for the commercial value of peach fruit. To unravel the underlying regulatory network in Prunus mira, we performed an integrated analysis of the transcriptome and metabolome of 3 fruit types with various flesh pigmentations (milk-white, yellow and blood) at 3 developmental stages (pit-hardening, cell enlargement and fruit ripening). RESULTS: Transcriptome analysis showed that an intense transcriptional adjustment is required for the transition from the pit-hardening to the cell enlargement stage. In contrast, few genes were differentially expressed (DEGs) from the cell enlargement to the fruit ripening stage and importantly, the 3 fruits displayed diverse transcriptional activities, indicating that difference in fruit flesh pigmentations mainly occurred during the ripening stage. We further investigated the DEGs between pairs of fruit types during the ripening stage and identified 563 DEGs representing the 'core transcriptome' associated with major differentiations between the 3 fruit types, including flesh pigmentation. Meanwhile, we analyzed the metabolome, particularly, at the ripening stage and uncovered 40 differential metabolites ('core metabolome') between the 3 fruit types including 5 anthocyanins, which may be the key molecules associated with flesh coloration. Finally, we constructed the regulatory network depicting the interactions between anthocyanins and important transcripts involved in fruit flesh coloration. CONCLUSIONS: The major metabolites and transcripts involved in fruit flesh coloration in P. mira were unraveled in this study providing valuable information which will undoubtedly assist in breeding towards improved fruit quality in peach.
HongJing I (HJI), a traditional Chinese herbal formula, has been confirmed to be effective for the clinical treatment of erectile dysfunction (ED). However, the mechanism of action of HJI remains unclear. Here, we aimed to investigate the effect and underlying mechanisms of HJI against ED in a rat model of bilateral cavernous nerve injury (BCNI). Rats were divided into five groups: normal control (NC), BCNI-induced ED model (M), M + low-dose HJI (HL), M + medium-dose HJI (HM), and M + high-dose HJI (HH). All groups were treated with normal saline or the relevant drug for 28 consecutive days after inducing BCNI-ED. At the end of the treatment period, the intracavernous pressure (ICP) was recorded, and histological examination was conducted using Masson's trichrome staining. Immunofluorescence staining and western blotting were applied to detect the changes in fibrosis protein and Ras homolog A (RhoA), Rho-associated protein kinase 1 (ROCK1), and ROCK2 expression. We found that HJI effectively improved the ICP in the treatment groups. In addition, RhoA, ROCK1, and ROCK2 expression levels were increased upon BCNI-ED induction, and HJI successfully inhibited cavernosum fibrosis and the activation of RhoA/ROCK2 signaling. Overall, these results suggest that the effects of HJI in attenuating ED may be caused, at least in part, by the suppression of RhoA/ROCK2 signaling and alleviation of fibrosis. However, the precise mechanism surrounding this requires further investigation in future studies.
OBJECTIVE: To study the expression levels of glial cell line-derived neurotrophic factor family receptor α-1 (GFRα1) and enhancer of zeste homolog 2 (EZH2) in the intestinal tissue of children with Hirschsprung's disease (HSCR), as well as the role of EZH2 in the regulation of GFRα1 gene expression and the pathogenesis of HSCR. METHODS: The samples of colon tissue with spasm from 24 children with HSCR after radical treatment of HSCR were selected as the experimental group, and the samples of necrotized colon tissue from 18 children with neonatal necrotizing enterocolitis after surgical resection were selected as the control group. Real-time PCR and Western blot were used to measure the expression levels of GFRα1 and EZH2 in colon tissue in both groups. Human neuroblastoma SH-SY5Y cells were divided into an EZH2 over-expression group and a negative control group. The cells in the EZH2 over-expression group were transfected with pCMV6-EZH2 plasmid, and those in the negative control group were transfected with pCMV6 plasmid. The expression levels of EZH2 and GFRα1 were measured after transfection. RESULTS: Compared with the control group, the experimental group had significant reductions in the mRNA and protein expression levels of GFRα1 and EZH2 in colon tissue (P<0.05), and the protein expression of EZH2 was positively correlated with that of GFRα1 (r=0.606, P=0.002). Compared with the negative control group, the EZH2 over-expression group had significant increases in the expression levels of EZH2 and GFRα1 after SH-SY5Y cells were transfected with EZH2 over-expression plasmid (P<0.05). CONCLUSIONS: Low expression of EZH2 in the colon tissue of children with HSCR may be one of the causes of inadequate expression of GFRα1 and onset of HSCR.


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Is an historic stock market crash about to unfold on Wall Street?
We sure don't know, and the pundits on CNBC and FBN are almost unanimous in saying there is nothing to worry about. As the saying goes, "Things always look brightest at the top.
Here's the past five days of US stock market trading (QQQ), courtesy of Trading View. Feel free to change the symbol, add lines and indicators etc, as you need.
5-Day Market Recap
Market Update Monday 02/17/20
US markets closed in observance of President's Day.
Stay tuned as the battle of the SkyNet StockBots continues.
Market Update Friday 02/14/20
The SkyNet StockBots slipped away early for the long holiday weekend as US stocks zigged and zagged their way to a modestly mixed close in relatively quiet trading. The DJIA slipped 25 points (0.1%) and the NASDAQ gained 19 points (0.2%).
Stay tuned as the battle of the SkyNet StockBots continues.
Market Update Thursday 02/13/20
The on-again off-again on-again off-again on-again off-again fears about the spreading of China's Coronavirus were back in "on" mode today, as the SkyNet SellBots took control of trading in overnight futures, sending US stocks lower at the open of trading on Wall Street. From there, stocks zigged and zagged their way into the close. The DJIA dropped 129 points (0.4%) and the NASDAQ slipped 14 points (0.1%).
Stay tuned as the battle of the SkyNet StockBots continues.
Market Update Wednesday 02/12/20
The buying panic resumed today as the Coronavirus is now seen as bullish, since the Federal Reserve and other central banks will flood the world with liquidity if the virus continues to spread. The SkyNet BuyBots took control of trading in overnight futures, sending US stocks higher at the open of trading on Wall Street. From there, stocks zigged and zagged their way to further gains into the close. The DJIA jumped 275 points (0.9%) and the NASDAQ surged 87 points (0.9%).
Stay tuned as the battle of the SkyNet StockBots continues.
Market Update Tuesday 02/11/20
US stocks zigged and zagged all day long as the SkyNet StockBots battled it out to a near draw. The DJIA broke even and the NASDAQ added 10 points (0.1%).
Stay tuned as the battle of the SkyNet StockBots continues.
So where do the markets go from here? We sure don't know.
And anybody who claims to know exactly what's coming is lying to you. The entire global financial system is in unprecedented, uncharted waters.
- Global debt is much worse than it was in 2007.
- Mega-trillions in derivatives trade every day like $1.00 dog-racing trifecta tickets.
- Despite twelve years of near-zero interest rates, global economies other than the US are barely registering a pulse.
- And on and on.
How bad are things? How unprecedented and uncharted?
Several Central Banks have entered the monetary Twilight Zone by cutting their benchmark interest rates to below zero. That's right, if you're a big bank, you can actually "make money" by borrowing money. When the loan comes due, you pay back less than the amount you borrowed. What a deal!
And the perverse flip side of negative interest rates is that when you deposit your hard-earned money in the bank, not only do you not earn any interest, the bank charges you a fee just for the privilege of making the deposit. You have less and less money in your account every day. What a rip-off!
All of this financial insanity can only be seen as a desperate last-resort attempt by Central Bankers to stimulate their economies by force-feeding them with "better than free money". (Free money that is conjured up out of thin air with a few mouse clicks, that is.)
About the best we can say for the markets ahead is "expect the unexpected."
But if there's one thing that all stock market analysts and forecasters agree upon, it's that "markets don't move in straight lines" (at least not for very long). Look at any chart of any stock, any commodity, anything that is traded on an open market and you just don't see long straight lines.
So if markets don't move in straight lines, how do they move? Again, look at any chart and it's obvious: markets move in zigs and zags. A more technical term for zigs and zags is waves. And there is no better way to analyze and interpret chart waves than with Elliott Wave analysis.
Founded in 1979 by Robert R. Prechter Jr., Elliott Wave International (EWI) is the largest independent financial analysis and market forecasting firm in the world. EWI's analysts cover every major market (stocks, currencies, bonds, energy, metals, commodities) worldwide, 24 hours a day.
The stock market waves have been warning of a major market meltdown for quite some time. Has that moment finally arrived?
As Bob Prechter warned, and as the market action during the 2008-2009 financial crisis proved,
"Bear markets move fast and are intensely emotional;
investors and traders who are prepared have greater
opportunities on the downside than on the upside."
We urge you to stay on top of the latest market action with commentary and reports from our friends at Elliott Wave International, below.


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text: Tuesday 4 February 2020 During last year's National Apprenticeship Week, we introduced you to Steph Howard, currently on the Construction Site Engineering Technician apprenticeship pathway and working at Such Salinger Peters Ltd as an Office Manager. Now in year two of her course, we caught up again to find out the last 12 months have been. Hi Steph, how has the last year been? My studies have been going great. We are now learning new subjects, the wide knowledge of what we have been learning has been useful. I have also been able to undertake a lot more jobs at work due to what I have learnt at University – it's really helped me with more of an understanding of the engineering world. What have you enjoyed the most about the last year of your apprenticeship? We have recently finished a surveying module which was quite practical, it made a change being out of the classroom. It was great experience learning with surveying equipment that I use in my day-to-day job which has helped by making me more confident when using the equipment at work. What have the biggest challenges been? As civil engineering is such a broad subject, some of the units we have been learning are less like what we undertake at my work place. These have been more challenging for me as I have no previous knowledge. However, it is great learning new things that I can take back to the office. What are your plans/hopes for the year ahead? I hope to pass the course at the end of this year! The year is going well, so fingers crossed. My next step in the career path would be to undertake a degree in Civil Engineering whilst continuing to work alongside the ICE (Institution of Civil Engineers) and become part of the professional association for Civil Engineers. Share this article Twitter Facebook LinkedIn Email Print


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Interfaces & Recording
Roland GO:Mixer Portable Audio Mixer
£59.99 £74.99
Compact, portable, and easy to use, the Roland GO:MIXER makes it simple to record high-quality audio in music videos and other video content created with your smartphone. Like other smartphone-ready audio equipment, Go:Mixer is plug-and-play ready, straight out the box. No complicated drivers to install!


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2020 Murano Winnipeg - No matter the reason, if end of every week watersports aren't within your plans, the Nissan Murano 2020 is a substantial decision for a trendy, agreeable five-traveler hybrid that conveys more style compared to standard. Eminently, we picked the 2020 Nissan Murano among Edmunds'Best Midsize SUVs over the current year.
2020 Nissan Murano Release Date , Review, Price 2020 Nissan Murano - The 2020 Nissan Murano can be to suit your needs if regular hybrid SUVs look like excessively exhausting. Introducing the 2020 Murano 5-passenger crossover, by using a daring fresh look and the most recent technology. Explore MPG, pricing and gives available within your area.
The 2020 Nissan Murano falls shy of some rivals in general load space, and unobtrusive towing limits help it become not about best for the individual's who call for a SUV which could tow trailers and toys.
2020 Murano Exterior
New spy shots are showing that Nissan is preparing refreshments for your Murano model. The already handsome crossover SUV can look even more attractive. The fresh look is significantly sharper, especially the top end. Revised headlights and LED running lights are looking brilliant. The happy couple of running lighting is arrow-shaped and it's like pointing at the midst of the grille.
A comfortable little bit of styling from Japanese carmaker. The boomerang-formed headlights incorporate with all the streamlined profile to find yourself a fundamental piece with the emotional general outline.
Accessible high-proficiency LED headlights make a light example that duplicates common sunshine. The potential LED Daytime Running Lights drastically curve about the headlights and offer a low-force, yet profoundly noticeable light. A different trapezoidal lower fascia is additionally visible about the spy shots. The back is included with minor changes only.
Camouflage over the taillights is suggesting a different pair of units. The side profile looks cleaner and we like the floating roof design. The 2020 Nissan Murano rides on standard 18-inch alloy wheels. The not compulsory 20-inch alloys also are available. You may even choose the Premium or Moonroof packages.
2020 Murano Interior
Nissan is usually a well-known carmaker generates the most pleasant cabins. The 2020 Nissan Murano is no exception. The interior is extremely upscale and modern. Already a modern cabin is certain to get further modernization concerning new features and updates of the present ones. The comfort is excellent, seats are big and are very supportive.
The cabin can accommodate up to 5 passengers across the 2 rows. An optional panoramic sunroof is usually a must-have. Cargo area offers 30 cubic feet of space. Folding the back seats starts up almost 70 cubic feet.
The Nissan Murano 2020 is enormous inside, yet no generally feel like it. It has abundant front and back headroom, notwithstanding for tenants a lot more than 6 feet tall. The wide inside gives a lot of shoulder and hiproom. You'll discover a lot of sidelong space and toe room under the top seats.
The tall hood harms forward perceivability, as do long, clearing front windshield columns. Raise quarter perceivability is merely OK due to little back window involving the rearmost columns. Blind side checking besides rearview and encompass see cameras enhance security.
The Murano's lodge quality punches over its weight, involving the cowhide surfaces, delicate touch focuses where elbows, arms and fingers associate, tasteful complexity twofold sewing and marvelous seats. Now you have an extravagance, Infiniti-like involvement. A 7-inch touchscreen offers a tremendous interface which is very all to easy to use.
Standard upholstery includes cloth materials. Of course, leather seats are offered and are optional. Telescoping tyre, dual-zone climate control , push-button start are common standard. When it comes to optional features, Murano offers remote start, Bose audio system, and power-adjustable front seats. In the future, Android Auto and Apple CarPlay are optional. For that end, the center console is slightly revised.
2020 Murano Specs
Gone will be the changes or upgrades in the hood. This would mean the 2020 Nissan Murano comes sticking with the same drivetrain option. A 3.5-liter V6 generates 260 horsepower and 240 lb-ft of torque. The V6 engine comes with a CVT transmission that's both fast and smooth. Because of that, the ride quality is way better and quiet.
Front-wheel-drive remains standard and the optional all-wheel-drive is available as well. The one engine choice currently offers 21 mpg in metropolis and 28 mpg about the highway. Those figures will continue intact in 2020. The crossover and SUV market currently is deploying many smaller four-cylinder engines. The downsizing with the drivetrains will certainly make Nissan give you a smaller and optional displacement towards 2020 Nissan Murano.
Climbing towards SV includes rooftop rails, foglights, remote motor begin, control flexible front seats, a calfskin wrapped guiding wheel, and blind side observing with raise cross-activity alarm.
The SV's discretionary Premium bundle includes exceptional 18-inch compound wheels, a encompassing sunroof, warmed front seats and mirrors, a 11-speaker Bose sound framework, and driver helps, by way of example, versatile voyage control , a 360-degree stopping camera framework, including a lazy driver cautioning framework (www.edmunds.com).
2020 Murano Release Date and Price
If you are an enthusiast of the auto, you need to will to comprehend since it is advisable to sustain longer. The release date with the auto is foreseen on 2020. Some auto experts are guessing that this auto, Nissan Murano 2020, cost is start from $40,000 for Europe and America auto markets.
The all-new 2020 Nissan Murano will cost $32,000. The SV trim is coming in at $35,000 and SL at $40,000. The range-topping Murano Platinum costs $44,000. Nissan's latest crossover SUV will arrive later in 2019 as being the 2020 model.