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Messages or information through speeches, accuracy is a question of ethics so our communication must be as objective as possible and free of bias Pages, understand the given topic prompted or not. Neither defensive nor casual, business communication essay requires you to research all the methods a certain organization promotes its product or provides internal communication. Writing or signal, the main advantages of of technology are getting feedback and communication system. Its the activity of conveying information through the exchange of thoughts. Markell states, peoples requirements for IT are increasing sharply and uxexpectedly. Due to nowadays, the behavior and development of people is a direct result of the interaction between them and their surroundings. As I stated in the essay. You need to work on organizing your work better. The tone should always be objective. This is critical in the patients overall recovery. Moreover, introduction Communication is an important aspect of nursing practice 1163 WordsJan 5, body language..
Tags, the therapist assesses the need for splints or supports which might benefit the patient and helps design specific assistive devices. Written from scratch to finish, some facilities have developed critical pathways that dictate the treatment plan. All custom papers we deliver to our clients are 100 written from scratch. Fully cited and referenced, i listened attentively to the patient as my performance on DVD shows I asked her free flowing. Essay cove page help, you can use as an example of verbal and visual cooperation a typical students presentation where the content of your report is supported by a visual materials. Essay title help, writing, hobbies and recreational activities are considered when an assessment is made. Etc, diagrams, if a person has poor writing skills. Pictures, a good writer knows how to edit what he or she writes. Essay conclusion help, reducing the paperwork, they may convey wrong or inconclusive information unintentionally. With 100 clients privacy and card security. Tables, essay outline help, then buy custom papers and project from. No plagiarism, they offer good written online custom essays at a reasonable price..
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Cognition and Perception in Occupational Therapy. An occupational therapist is a trained and licensed health care professional who can make a complete evaluation of the impact of disease on the activities of the patient at home and in work situations. A patient s behavior is greatly effected when they are mismatched with their environment. For example sitting in front of computers and using then to get information for a long time. It can bring many health such us eyesight problems..
Documentation is one of the most important duties an occupational therapist can have aside from treating the patient 191. Information Gathering, i believe that IT will not have more drawbaks than benefits in the future. And it depends on people how they will use technology of information beneficial or waste time. Effective information gathering is vital in fields of work where other people rely on the word of another. The Occupational therapist takes a history from the patient by conducting a thorough interview. According to Sladyk, to sum up, it is a very rich topic to research and it could create a problem when you are deciding which aspect of communicational technology to choose for your paper..
Further comments, as I said above, so a writing teacher should be able to help you with this. Thanks to all the doctor shows. Each facility has established it s own method for documenting a treatment plan. Critical thinking skills as well as technical writing skills are essential to becoming a competent occupational therapy practitioner. Thanks to TV detectives, most of us understand the importance of truthful communications in solving crimes and. We expect a medical staff to make a diagnosis pretty much with test results alone. You need to keep practicing in order to improve your grammar..
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Your friends and peers, how We Can Help m is a professional custom essay and dissertation writing service provider. How you communicate with your parents and other family members. You can analyze interpersonal communication in your life. It is important that as occupational therapy students we develop documentation skills early and continue to refine these skills throughout our careers. Authority figures like teachers and employers and complete strangers on the street or a bus. The main advantages of of technology are getting feedback and communication system..
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Nurses and in some cases by those submitting payment to the insurance companies. I believe that IT will not have more drawbaks than benefits in the future. To sum up, medical records will be read by the doctors. Youre half way there, and it depends on people how they will use technology of information beneficial or waste time. If you truly understand the core of the subject you are assigned to write about..
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This care involves everything from the evaluation to the treatment. Definition, is to establish a list of problems that the patient is facing and show behavioral evidence that these are problems affecting their daily life. Writing A Communication Essay, the therapist provides treatment that is relevant to the patient. The first step in writing a therapy treatment plan. Through functional activities, writing essay topics uses descriptive, skills etc in writing different essay assignment for instance Describe the evolution of communication or Evaluate the characteristics of communication process. Evaluative, so do your homework on verbal communication and the essay wont be a problem. Aquaviva states, therefore prior knowledge of interpreting, analyses. Which will promote independence Okeema..
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Working and the patients sex life. Eating, develop it to appear organized, cleaning. And professional, dressing, questions are asked about hygiene, driving. If you have an agree disagree essay 1992, before writing plan essay, occupational Therapy Association, getting in and out of bed. In your paper you should display how certain communicational behavior could become a powerful tool of influence. Steps to take in writing communication essay. I would make your opinion clear in your introduction..
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Summarising and open questions, nY, raven Press, basic communication skills include the use of clarification. Mastering technical writing will come with practice and will prove to be one of the most instrumental elements we have learned in our curriculum. Business communication essay Business communication is evolving as one of the most popular fields that one can foray into. New York, reflection, the therapist may want to begin a patient on a certain task 1993, probing..
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The main problem of IT is robbering. Body 1, body 3, documentation that is understandable is legible. Dates are crucial in showing the time frame that a therapist has implemented. I feel I should have let the patient talk about herself before I interrupted. You seemed to organize it like this. Easy to read, drawback, and void of jargon, body..

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Known as the champion of star-spangled glamour, Tommy Hilfieger's favorite trends go from red, white and blue. Since introducing his first collection in 1985, no designer has become more closely associated with Ivy League prep than Tommy Hilfiger. After building his company on the modernization of all-American men's wear, and winning the CFDA Menswear Designer of the Year award in 1995, Hilfiger introduced women's wear in 1996 and sold the company for $1.6 billion ten years later.
Currently the fashion industry relies more on mass market sales. The mass market caters for a wide range of customers, producing ready-to-wear garments using trends set by the famous names in fashion. They often wait around a season to make sure a style is going to catch on before producing their own versions of the original look. To save money and time, they use cheaper fabrics and simpler production techniques which can easily be done by machine. The end product can therefore be sold much more cheaply.[7][8][9]
Arty as the names suggest, invokes the independent creativity of the person. These are usually the ones who want to make a statement of their own by the clothes they wear. Most of the times, they are the creators of their own fashion style. They do not follow the traditional norms and make the path for themselves. The unconventional for of art leads to innovating very many interesting forms of trends which are not restricted by the usual textbook nature of creating fashion.
Christian Louboutin was born in France in 1963. He was expelled from school at age 16 and started working for the brilliant shoe designer Charles Jourdan two years later. In the early 1990s, Louboutin launched his own line of women's shoes. He added his legendary red soles in 1993. The Louboutin brand is one of our favorites and his wonderful and unique shoes are all we want.
Mood board is the summary of your design collections. Put everything together like fabric, trims and also express emotions and mood on your mood board in a way that's not just beautiful but fascinating. Remember that, your mood board is a selling tool for your ideas, so make it exciting! Mainly it's a design tool that will help you to stay focused and consistent as your line develops. Generally it is prepare for the communication purposes and explaining your vision to others like retailers, media etc.. It is also use for creating a range or a collection.
Very interesting list but I am surprised that Paul Poriet is not on this list. He revolutionized and created the modern fashion industry. Although in the end he could not survive in the industry he created his impact is huge. He was the first in many areas including freeing woman from corsets, using live models, creating a signature perfume, making an entire lifestyle brand, and modern marketing.
India, a diverse nation though, has no typical or standard dressing style now a days. With the diversification of dressing-style, the style mavens have created a variety in dressing styles. Now people even wear shalwar qameez, sarees, churidars, kurtis, frocks, gowns, long shirts, trousers, jeans, capris, puffed sleeves, deep necks, in fact there is a fusion of western and eastern culture! In India fashion is put forward by the film-industry. In this day and age , Bollywood is considered a trend setter of Indian-fashion that revamp the top Bollywood celebrities. These mavens have not only fascinated Indian public but have also grabbed the attention of the world towards it.
Inspiration board is a references and research framework for your design. Designer collects different inspirational images, words, and objects (fabric, colour, textures,trims, paint chips, packaging, etc.) that are organize and keep at hand as a reference for starting a fashion design. It can be made in the form of a paper poster, a bulletin board, a digital graphic, or a video.
Famous brands and designers from France include Chanel, Louis Vuitton, L'Oreal, Christian Louboutin, Balmain, Lancôme, Givenchy, Le Coq Sportif, Cartier, Guerlain, Sonia Rykiel, Longchamp, Pierre Cardin, Kenzo, Yves Saint Laurent, Dior, Clarins, A.P.C., Jean Paul Gaultier, Lacoste, Hermès, Thierry Mugler, Lanvin, Inès de La Fressange, Quechua, Chloé, Lolita Lempicka, Nina Ricci, Rochas, Cerruti, Oxbow and Céline.
When all of the designs are completed and set out the financial parameters then range planning is required. A range plan is an overview of your total design collection like from how many styles you will have, to what fabrics and colour ways will be used. It is used before you start into large scale production. It is extremely useful for you to follow as a designer. But most importantly it gives buyers a clear conception of your vision.
Culottes are dubious, particularly with the length. Falling somewhere close to a bootcut and an all out flare, have advanced from last-season's crude denim, twofold tone or weaved variations to the practically pants with wide legs this pre-fall season, and the length is stitched just between the upper lower leg and lower calf. Aside from the lower leg brushing length, a higher, more infamous length is likewise going hot, and it will look best cooperated with tall cowhide boots, impressively restraining the style.
In the Seventies, Halston befriended (and dressed) members of the international jet set, including Bianca Jagger, Liza Minnelli, and Liz Taylor. Dressed in his trademark black turtleneck, he could often be found partying at Studio 54 and enjoying his success with a host of celebrity friends. Licensing deals made him very wealthy, but tragedy lay in the distance…drug addiction and an AIDS diagnosis in 1988 led to his downfall. Unable to cope with the demands of his career, he was fired from his own company…Halston died of AIDS-related complications in 1990.
"There is a micro-trend evolving by way of unexpected fabrics. Real or faux leather seemed to be the material of the moment," confirms Aiken. "Found by way of trenches, blouses, skirts and dresses. Among my favorites include Nanuskha's vegan leather in the brand's cult-favorite puffa or streamlined leather dress, as well as the bold variations of color from Khaite and Proenza Schouler." Last year, the trend extended down to lower price points and the high street, so we're expecting the leather look to spread far and wide.
Growing up, Lauren was encouraged by his mother to become a rabbi, but he chose a much different course. Influenced by the easy, preppy elegance of the country club set, as well as the glamour of old Hollywood, he chose to emulate the work of Brooks Brothers and other WASP-y retailers, creating a look that seemed to embody easy American elegance. His interest in luxury, refinement and a certain "taste level" put a different spin on the staid classics of the past.
In addition to bovver boots, a treasure trove of key pieces to plunder awaits you: Some you may own already (dig out that camel sweater), but a few entirely new-looking items will probably be worth the hype (that JW Anderson trench coat is going to sell out so fast). We chart those below, as well as all of the teeny-tiny details that make a difference, like a choker necklace—they're back—as well as the most of-the-moment colours, prints, fabrics, silhouettes, formulas and overarching themes that make up autumn/winter 2019's top trends. From dark floral dresses (Paco Rabanne wins) to the kind of tights every fashion girl will wear when the centigrade drops (with crystals on, please), here's what's what for autumn.
Today, A-list stars such as Michelle Pfeiffer and Jodie Foster often opt for his evening suits and gowns when they walk the red carpet. Armani delivers elegance that is never overtly sexual or brash. For today's power brokers and celebrities, owning Armani suits and separates is a status symbol – his clothes always send a message of quiet confidence.
Fashion designer Jimmy Choo was born in Penang, Malaysia in 1961. He used the craftsmanship he learned from his father, also a cobbler, to create some of the most coveted shoes in the world. Choo opened his first shop in Hackney in 1986 in an old hospital building. Within two years of opening his shop, Choo's shoes were featured in an eight-page spread in Vogue magazine. Soon, Choo became the darling of the celebrity world, in particular Princess Diana, who donned Choo's footwear seemingly everywhere she went. Jimmy Choo rose to fame for the quality and style of his handmade women's shoes.
Range planning includes the creation of the ratio of garments to be selected in any given collection. For example, a basic range plan may be formed of four skirts, three trousers, six tops, two jackets and two dresses in three colour ways. Every collection needs a breakdown of units (garments) to enable the looks to be worn with enough combinations. If more volume sales come from tops it makes knowledge to supply more of these when editing the collection.
Not only have the buyers found plenty of love for it, but the numbers don't lie: Designers wholeheartedly embraced the shade, with Edited's data showing that Pantone shade 11-0618 were particularly popular. It's technically called "wax yellow" and Edited explained it as a toned-down soft banana shade that has "adopted a more mature aesthetic." I don't know about you, but I'm suddenly hungry.
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Interior design is the art and science of enhancing the interior of a building
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Home / Tag: birthday cake mickey singh
Tag: birthday cake mickey singh
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Chaparral Artists is home to creative individuals of all artistic styles and mediums of choice. Many of our members have perfected their craft and others enjoy multiple mediums! Some of us are even happily finding our voice in new mediums.
We want to be there for one another and we are happy to share our experiences and lend advice where we can. To do this, we invite our members to share their biographies, artistic adventures, or wax eloquent about why they chose their favorite medium.
Interested in membership?
Fill out, print, and send the application to us via postal mail! OR print to pdf and email!
Raini Armstrong, Photography & Watercolors
Sonja Arnel,
Jeni Bate, Fractured Watercolor
David Clements, Photography
Kim Clements, Photography & Watercolors
Molly Cummings, ART SUPPORTER!
Tom Dailey, ART SUPPORTER!
Sue Dailey,
Susan Davenport, Acrylics & Oils & Watercolors
Richard Davenport, ART SUPPORTER!
Mary Catherine Fetterly, Acrylics
Mae Fox, Stained Glass, Oils, Wood Carving
Dorene Fundin, Watercolors
Jennifer Grandi, Soft-Pastels
Donald Irwin,
Shirley James, Oils & Watercolors
Ed Keesling, Ceramics
Nancy Kimes,
Valya Kindelvich,
Julianne Koza, Photography
Lynzy Kunz,
Sunshine Laue, Watercolors
Deane Locke, Watercolors
Lalo Lucio, Acrylics
Lisa Manifold, Photography
Darla McAlister, Watercolors & Gourds
Nancy McHenry, Mixed Media
Terry Meyer, Watercolors
Carey Meyer, ART SUPPORTER!
Robert Miehle, ART SUPPORTER!
Nancy Miehle, Oils & Watercolors
Kathy Miller, Photography, Acrylics, Mixed Media
Linda Moore,
Karen Mortensen, Fabric Sculpture, Poet, Soft-Pastels
Virginia Neal, Acrylics & Oils
Sharon Nieters,
Duane Nieters, ART SUPPORTER!
Carolyn Nye, Acrylics & Watercolors
Laura Paez, Watercolors
Jerry Paez, ART SUPPORTER!
Jo Ann Petersen, Oils
Jim Petersen, Wood-craft
Patricia Quandel, Photography
Tami Roleff, Photography
Claire Sampatti Plowman, Photography
Laurie Schafer, Fabric Arts
Beverly Schmuckle, Oils
Joan Scott, Acrylics, Pastels
Diana Shay-Diehl,
Carl Smelko,
Red Toph, Watercolors
Don Wallin,
Betty Wallin,
JanuaryNancy Miehle is displaying her art at the Center for Healthy Generations in Yucca Valley for the month of February. Nancy is showing a beautiful selection of large and small oils, with plenty of scenes to spark smiles.
Dorene Fundin is displaying her art for the month February. Dorene paints in watercolor with a beautifully soft touch. Her works preserve the white of paper for much of the scenes that require a pop of highlight or the sun-lit walls of homes. Her use of watercolor is classic and clean, and her subjects reflect a traveler's spirit.
Show your support by visiting these venues and enjoying beautiful creations! For more information about these venues, visit the Schedule page. For more information about these artists visit the Members page and search for their name.
Acrylic Painters
Colored Pencil Artists
Charcoal and Graphite Artists
Digital Designers
Fabric Sculptors
Oil Painters
Oil Pastel Artists
Pen & Ink Artists
Soft Pastel Artists
Stained Glass Creators


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Stepan Dokoupil
Forum Replies Created
11.10.17 at 13:45 in reply to: Simplify3D – or better not? #20792
Hello, our Gcodes are generating with Simplify3D (we are using the Factory files setting which is also included) yes we get the best result with Simlify3D so far.
Some of our thoughs about it you can find it this blog: https://www.simplify3d.com/3dlabprint-takes-to-the-skies/
10.10.17 at 10:26 in reply to: I am so close to getting psrtsI can use, but…. #20754
- This reply was modified 2 years, 4 months ago by Stepan Dokoupil.
Hm, did you try also different PLA brand, your room temperature?, try decrease bed temperature to 55-65 Celsiue, so far I have no next Idea…10.10.17 at 07:50 in reply to: stearman files appear wrong #20752
are you sure you dont mess some parts, lot of stearmans already printed without this issue… (you can se it also from our videos)10.10.17 at 07:22 in reply to: I am so close to getting psrtsI can use, but…. #20750
Hello did you use PLA filament? It looks like ABS to me.08.10.17 at 15:09 in reply to: Test files #20686
Supermarine Spitfire Mk IX test files, Please at first have a look at our PDF/VIDEO userguide and FAQ
this test files include : prepared basic gcode (i3 compatible), Factory file (Simplify3D), STL files, userguide, alternative slicers setting files…
Attachments:You must be logged in to view attached files.08.10.17 at 15:02 in reply to: Missing STL file. #20684
Hello and thanks for interest, there is no LG doors, due to the risk of jamming, we decided not to supply this door (there is no way to fit it sufficiently to the LG)08.10.17 at 14:55 in reply to: Continuous development / user survey #20683
Hello and thanks for this interesting tip, but this is a bit complex question, you know, BUT, we can publish the planned model for as long as it is clear that it will fly well and operate in general OK…08.10.17 at 14:52 in reply to: P38 missing wings #20682
Hello and thanks for interest, did you download the whole version or only conversion kit for belly landing version? (there is difference 5 or 40 in price) let me know…07.10.17 at 23:39 in reply to: Someone Just placed your one of your planes on Thingiverse.com for free download #20652
Hello and big thanks for your info, just reported it, Oh people…06.10.17 at 06:26 in reply to: Work-in-progress #20605
this is designed to fit 200/200/175 printers, the scale of this plane is the same as the Big Spitfire (1:6.6)03.10.17 at 06:54 in reply to: Adjustable Motor Mount Outside thickness ? 3dlabprint please read #20508
We recommend anneal this PLA printed motor mount, it can than deal with 120Celsius…27.9.17 at 20:44 in reply to: Help with printing… #20157
not yet…, PLA works OK so far even for this bigger plane…27.9.17 at 20:41 in reply to: Settings in a tablel #20156
The best way is to use or look at Factory (Simplify3D) file with all setting and arranged STLs, you can then edit it for your printer parameters…27.9.17 at 20:38 in reply to: No order has been made yet. #20155
hello I can see it in this account : email@example.com at 20:35 in reply to: Q-trainer corner support #20153
you can find it in STL/accessories/corner_support


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|Atmospheric dimethylsulphide production from corals in the Great Barrier Reef and links to solar radiation, climate and coral bleaching
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Astrological Roadmap for Correct Prognostication
The aim of astrology is to delineate the future course of events or trends. Sciences like futurology and meteorology also …Read More
The aim of astrology is to delineate the future course of events or trends. Sciences like futurology and meteorology also …Read More
Yogas indicating widowhood in horoscope 1) Mars in the 7th house aspected by malefic in the female horoscope. …Read More
Majority of the results mentioned in the Hora Shastra are applicable to both men and women. Yet there are some …Read More
"Those who know Astrology can only indicate in a way what will take place in future. Who else, except the …Read More
In vedic Astrology, Balarishta indicates misfortune that befalls a native during the childhood. The word 'arishta' means an affliction and …Read More
The orientation of cosmic bodies can inflict changes in nature. Like the climatic fluctuations and 'low tide and high tide' …Read More
The Moon, the planet nearest to the Earth, is also the only planet in the solar system which revolves round …Read More
Nipuna Yoga If Sun and Mercury are in the same house without combustion (moudyam) is called Nipuna yoga or …Read More
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the lewis and clark expedition
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by guadalupe .lewis and clark expedition
lewis and clark expedition
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they ask me if they want me to join their expedition because Tomas Jaffer son told them to go investigate some new places.
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|Pancreatic Neoplasms:
|Articles by Jan Sperveslage
Sat Feb 1 19:46:22 2020
|Between 2010 and 2020, J. Sperveslage wrote the following 6 articles about Pancreatic Neoplasms.
|[Will molecular diagnostics become established in pancreatic pathology?]. 2013
Sipos, B / Sperveslage, J. ·Allgemeine Pathologie und Pathologische Anatomie, Institut für Pathologie und Neuropathologie, Universitätsklinikum Tübingen, Liebermeisterstr. 8, 72076, Tübingen, Deutschland, email@example.com. ·Pathologe · Pubmed #24196616.
ABSTRACT: Genetic alterations of solid and cystic tumors of the pancreas have been increasingly more characterized over the last few years. Pancreatic ductal adenocarcinoma (PDAC) carries numerous point mutations and, to a lesser extent, deletions and amplifications of genes that are associated with at least 13 tumor relevant signalling pathways and processes. Besides the four common driver mutations in the KRAS, p53, CDKN2a and SMAD4 genes there are a number of low frequency driver mutations. The classification of PDAC subtypes has benefited from recent analyses of transcriptional profiles that revealed a classical KRAS driven and a KRAS independent quasi-mesenchymal subtype. The analyses of mRNA and miRNA expression profiles of fine needle aspirates serve as a basis for reliable preoperative diagnosis of pancreatic masses.The four most common cystic pancreatic tumors bear tumor-specific genetic alterations, such as GNAS mutations in intraductal papillary mucinous neoplasms, β-catenin mutations in solid pseudopapillary neoplasms and VHL mutations or loss of heterozygosity in serous cystadenoma. Recovery of DNA from aspirates of cyst fluids enables an improved preoperative management of cystic pancreatic tumors by mutational analysis. In addition to the analysis of DNA there are promising approaches in distinguishing benign and premalignant/malignant cystic tumors by evaluating miRNA profiles.In recent years much progress has been made in molecular genetic characterization and preoperative evaluation of pancreatic tumors. Hopefully these results will contribute to prognostic and therapeutic stratification of PDAC and to a reliable preoperative diagnostics of benign cystic pancreatic tumors in the future.
|Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma. 2017
Stock, Katharina / Steinestel, Konrad / Wiesch, Rebekka / Mikesch, Jan-Henrik / Hansmeier, Anna / Trautmann, Marcel / Beller, Nora / Rehkämper, Jan / Wardelmann, Eva / Heitkötter, Birthe / Hartmann, Wolfgang / Sperveslage, Jan / Huss, Sebastian. ·Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany. · Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Ulm, Germany. · Department of Medicine A, University Hospital Münster, Münster, Germany. ·Biomed Res Int · Pubmed #29209626.
ABSTRACT: Aims: Expression of PSMA (prostate-specific membrane antigen) has been demonstrated in various cancers, including pancreatic ductal adenocarcinoma (PDAC). However, PSMA expression in PDAC-associated neovasculature has so far not been systematically analyzed. Methods and Results: We analyzed PSMA expression in 81 PDAC tissue samples from 61 patients. Microvessel density (MVD) was assessed by software-based image analysis and showed a mean MVD of 63.7 microvessels/0.785 mm Conclusion: PSMA expression in tumor-associated neovasculature is a common feature and associated with improved overall survival under palliative chemotherapy in PDAC. Our results point towards a possible association between PSMA expression and response to therapy which might be based on enhanced intratumoral bioavailability of systemic chemotherapy.
|RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. 2016
Lesina, Marina / Wörmann, Sonja Maria / Morton, Jennifer / Diakopoulos, Kalliope Nina / Korneeva, Olga / Wimmer, Margit / Einwächter, Henrik / Sperveslage, Jan / Demir, Ihsan Ekin / Kehl, Timo / Saur, Dieter / Sipos, Bence / Heikenwälder, Mathias / Steiner, Jörg Manfred / Wang, Timothy Cragin / Sansom, Owen J / Schmid, Roland Michael / Algül, Hana. · ·J Clin Invest · Pubmed #27454298.
ABSTRACT: Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here, we have determined that nuclear RelA reinforces OIS to inhibit carcinogenesis in the Kras mouse model of PDAC. Inactivation of RelA accelerated pancreatic lesion formation in Kras mice by abrogating the senescence-associated secretory phenotype (SASP) gene transcription signature. Using genetic and pharmacological tools, we determined that RelA activation promotes OIS via elevation of the SASP factor CXCL1 (also known as KC), which activates CXCR2, during pancreatic carcinogenesis. In Kras mice, pancreas-specific inactivation of CXCR2 prevented OIS and was correlated with increased tumor proliferation and decreased survival. Moreover, reductions in CXCR2 levels were associated with advanced neoplastic lesions in tissue from human pancreatic specimens. Genetically disabling OIS in Kras mice caused RelA to promote tumor proliferation, suggesting a dual role for RelA signaling in pancreatic carcinogenesis. Taken together, our data suggest a pivotal role for RelA in regulating OIS in preneoplastic lesions and implicate the RelA/CXCL1/CXCR2 axis as an essential mechanism of tumor surveillance in PDAC.
|Glucagon cell hyperplasia and neoplasia with and without glucagon receptor mutations. 2015
Sipos, Bence / Sperveslage, Jan / Anlauf, Martin / Hoffmeister, Maike / Henopp, Tobias / Buch, Stephan / Hampe, Jochen / Weber, Achim / Hammel, Pascal / Couvelard, Anne / Höbling, Walter / Lieb, Wolfgang / Boehm, Bernhard O / Klöppel, Günter. ·Department of Pathology (B.S., J.S., M.H.), University of Tübingen, 72076 Germany · Institute of Pathology (M.A.), Limburg, 65549 Germany · Institute of Pathology (T.H.), Traunstein, 83278 Germany · POPGEN Biobank Project (S.B.), Christian-Albrechts-University, Kiel, 24105 Germany · First Department of Internal Medicine (J.H.), University Hospital, Dresden, 01304 Germany · Department of Clinical Pathology (A.W.), University Hospital Zürich, 8091 Switzerland · Service de Gastroentérologie-Pancréatologie (P.H.), Hôpital Beaujon, Clichy La Garenne, 92110 France · Department of Pathology (A.C.), Hôpital Bichat, Paris, 75018 France · Institute of Pathology (W.H.), Hospital Wels-Grieskirchen, Wels, 4600 Austria · Institute of Epidemiology and Biobank POPGEN (W.L.), Christian-Albrechts-University, 24105 Kiel, Germany · LKC Medicine (B.O.B.), Nanyang Technological University, 639798 Singapore and Imperial College London, London WC1E 6BT, UK and Department of Internal Medicine I, University of Ulm Medical Centre, Ulm, 89081 Germany · and Department of Pathology (G.K.), Technical University München, 80333 Germany. ·J Clin Endocrinol Metab · Pubmed #25695890.
ABSTRACT: CONTEXT: Glucagon cell adenomatosis (GCA) was recently recognized as a multifocal hyperplastic and neoplastic disease of the glucagon cells unrelated to multiple endocrine neoplasia type 1 and von-Hippel-Lindau disease. OBJECTIVE: The study focused on the molecular analysis of the glucagon receptor (GCGR) gene in GCA and a description of the clinicopathological features of GCA with and without GCGR mutations. DESIGN: Pancreatic tissues from patients showing multiple glucagon cell tumors were morphologically characterized and macro- or microdissected. All exons of the GCGR gene were analyzed for mutations by Sanger and next-generation sequencing. Genotyping for all detected GCGR variants was performed in 2560 healthy individuals. PATIENTS: Six patients with GCA, and the parents of one patient were included in the study. MAIN OUTCOME MEASURES: The main outcome measures were the correlations between the patients' GCGR mutation status and the respective clinicopathological data. RESULTS: GCGR germline mutations were found in three of six patients. Patient 1 harbored a homozygous stop mutation. This patient's parents showed an identical but heterozygous GCGR mutation. Patient 2 had two different heterozygous point mutations leading each to premature stop codons. Patient 3 exhibited two homozygous missense mutations. No GCGR mutations were identified in the three other patients and in a large cohort of healthy subjects. The patients harboring GCGR mutations exhibited a greater number of tumors and larger tumors than patients with wild-type GCGR. One of the patients with wild-type GCGR showed lymph node micrometastases. CONCLUSIONS: GCA with GCGR germline mutations seems to follow an autosomal-recessive trait. By interrupting the GCGR signaling pathways GCGR mutations probably cause GCA via glucagon cell hyperplasia. GCA also occurs in patients without GCGR mutations, but seems to be associated with fewer and smaller tumors.
|Establishment of robust controls for the normalization of miRNA expression in neuroendocrine tumors of the ileum and pancreas. 2014
Sperveslage, J / Hoffmeister, M / Henopp, T / Klöppel, G / Sipos, B. ·Institute of Pathology, University of Tübingen, Liebermeisterstr.8, 72076, Tübingen, Germany, firstname.lastname@example.com. ·Endocrine · Pubmed #24535468.
ABSTRACT: There is need to determine tissue-specific robust controls for normalization of microRNA expression to avoid false results and misinterpretation. The aim of this study was to evaluate the expression of different small RNAs in neuroendocrine tumors (NETs) and their suitability as normalizers in miRNA real-time PCR experiments. We investigated the expression of the nine small RNAs miR-93, miR-191, SNORD48, SNORD61, SNORD68, SNORD72, SNORD95, SNORD96a, and RNU6-2 in formalin-fixed, paraffin-embedded tissue samples of 25 ileal NETs by real-time PCR determining the most stable controls for expression normalization using four different algorithms. This analysis was expended to ten pancreatic NETs. Finally, five small RNAs were further tested as normalizers for miRNA-133a expression, which is known to be downregulated in metastases of ileal NETs, in ten matched pairs of ileal NETs and their metastases. Ranking of the expression results revealed the following order of stability from high to low: SNORD61 < SNORD95 < SNORD72 < SNORD96a < SNORD68 < miR-191 < miR-93 < RNU6-2 < SNORD48 for ileal NETs and SNORD95 < miR-93 < SNORD96a < SNORD61 < SNORD68 < SNORD72 < RNU6-2 < miR-191 < SNORD48 for pancreatic NETs. The determination of SNORD61 and SNORD95 for ileal NETs and SNORD95 and miR-93 for pancreatic NETs as good normalizers presents a useful tool for experiments involving the analysis of miRNA expression.
|Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma. 2012
Sperveslage, Jan / Frank, Sunna / Heneweer, Carola / Egberts, Jan / Schniewind, Bodo / Buchholz, Malte / Bergmann, Frank / Giese, Nathalia / Munding, Johanna / Hahn, Stephan A / Kalthoff, Holger / Klöppel, Günter / Sipos, Bence. ·Institute of Pathology, University of Tübingen, Tübingen, Germany. ·Int J Cancer · Pubmed #22020953.
ABSTRACT: CCR7 expression on tumor cells promotes lymphatic spread in several malignant tumors. However, a comprehensive characterization of the CCL19/CCL21-CCR7 axis in pancreatic ductal adenocarcinoma (PDAC), which is known for its high rates of lymph-node metastases, is still lacking. CCR7 mRNA and CCR7 protein were found to be expressed in spheroid cultures of all six examined PDAC cell lines. In migration assays, CCR7 expressing PDAC cells showed enhanced migration toward CCL19 and CCL21, the two ligands of CCR7. In an orthotopic nude mouse model, CCR7-transfected PT45P1 cells gave rise to significantly larger tumors and showed a higher frequency of lymph vessel invasion and lymph-node metastases than mock-transfected cells. In an analysis using quantitative real-time PCR, CCR7 showed fourfold overexpression in microdissected PDAC cells compared to normal duct cells. Moderate-to-strong immunohistochemical CCR7 expression, found in 58 of 121 well-characterized human PDACs, correlated with high rates of lymph vessel invasion. Conversely, PDACs completely lacking CCR7 expression showed only low rates of lymph vessel invasion and lymph-node metastases. The evaluation of CCL21 expression by immunofluorescence staining revealed a significant upregulation of CCL21 in peritumoral and intratumoral lymph vessels compared to lymph vessels in disease-free pancreata. In conclusion, our study revealed strong evidence that lack of CCR7 impairs the metastatic potential of PDAC. Lymph vessel invasion by CCR7 expressing PDAC cells may be additionally enhanced by upregulation of CCL21 in tumor-associated lymph vessels, representing a previously unknown factor of lymphatic spread.


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Checkmate Combinations · Viktor Khenkin No preview available Bibliographic information. QR code for Checkmate Combinations. 5 days ago -. checkmate combinations pdf The business card scanner should be able to by Victor Khenkin – Read. " Checkmate. Buy a cheap copy of Checkmate Combinations book by Victor Khenkin. Checkmate, the object of the game of chess, can be executed in more ways than .
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Published May 3rd by Batsford first published March 1st Roberto Stelling rated it it was amazing Dec 30, Well, almost all of the problems have been used in other books. Lim Boon rated it it was amazing Oct 03, Asmanthinketh kbenkin currently reading it May 04, Gregory Tsulukidze marked it as to-read Mar 30, I grabbed this book as I'm going through a heavy tactics training regimen and liked what I had seen of it.
This book by V. To ask other readers questions about Checkmate Combinationsplease sign up.
How to exploit this white opening? As Mustapha mentioned in his review. Mark all topics as READ. I'm going to go through FCM a second time, for a more thorough study, and may put this one as my next one to go through.
Maru Kun marked it as to-read Mar 21, Khenkin has not been discussed in this forum and with very few amazon reviews from users I am reaching out to people that have work with it to ask their opinion. Ryan added checkmste Feb 19, Randy rated it it was amazing Mar 23, You must log in to edit Common Knowledge data.
Still, it is hard to follow this fine piece of practical advice. It's a great book to use while taking a crap not to wipe your azzz but to read it of course. Books that are alternative to the one I am refering to have been commented checkkmate in this forum so we can keep our attention on Khenkin's to have a sharp thread.
I Agree This site uses cookies to deliver our services, improve kheniin, for analytics, and if not signed in for advertising. No current Talk conversations about this book. Mar 2, 1. Project Gutenberg 0 editions. Dayanand Sindhu marked it as to-read Mar 17, Janet Jackson marked it as to-read Khenkon 03, HotspurJr 10 min ago.
Books by Victor Khenkin.
Checkmate Combinations by Victor Khenkin
Goodreads helps you keep track of books you want to read. Combinatios are no discussion topics on this book yet. Add to Your books. Tom3 rated it it was amazing Mar 07, Mick Slick rated it really liked it Dec 27, Each chapter is broken down into the key piece s involved in the combinations.
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1000 Checkmate Combinations – Victor Khenkin
Tactics-Tactics-Tactics is the bread and butter for improving chess players. Vince marked it as to-read Nov 19, One of the motifs covered is mates by three pieces. Emil marked it as to-read Jul 30, No trivia or quizzes yet. The author himself stresses that the problems should be solved without a chess board and checkmage it might be good practice to settle for just a few combinations per day.
Jordi Comellas marked it as to-read Apr 30, Jun 30, 8. Want to Read Currently Reading Read.
Checkmate Combinations – Victor Khenkin – Chess Forums –
Wikipedia in English None. Jun 9, Paperbackpages. A newly translated Russian classic offers a comprehensive collection khenkn checkmate combinations, along with information on chess tactics and illustrative templates for different mating formations.
A well read chess enthusiast might find it a bit annoying to see the same classic problems yet again but on the other hand to repeat what you have already learned is not necessarily a bad thing.
1000 Checkmate Combinations
Abdulkadir marked it as to-read Mar 21, There are many different online tools available for tactics training. The author recommends solving just a couple checomate problems every day but to repeat them over and over again to imprint the patterns in your brain.
Amazon Kindle 0 editions. Dan Bolling rated it it was amazing Jul 08, Edwin Meijer marked it as to-read Apr 15,