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OBJECTIVE: Genetic risk scores (GRS) have been developed that differentiate individuals with type 1 diabetes from those with other forms of diabetes and are starting to be used for population screening; however, most studies were conducted in European-ancestry populations. This study identifies novel genetic variants associated with type 1 diabetes risk in African-ancestry participants and develops an African-specific GRS. RESEARCH DESIGN AND METHODS: We generated single nucleotide polymorphism (SNP) data with the ImmunoChip on 1,021 African-ancestry participants with type 1 diabetes and 2,928 control participants. HLA class I and class II alleles were imputed using SNP2HLA. Logistic regression models were used to identify genome-wide significant (P < 5.0 × 10-8) SNPs associated with type 1 diabetes in the African-ancestry samples and validate SNPs associated with risk in known European-ancestry loci (P < 2.79 × 10-5). RESULTS: African-specific (HLA-DQA1*03:01-HLA-DQB1*02:01) and known European-ancestry HLA haplotypes (HLA-DRB1*03:01-HLA-DQA1*05:01-HLA-DQB1*02:01, HLA-DRB1*04:01-HLA-DQA1*03:01-HLA-DQB1*03:02) were significantly associated with type 1 diabetes risk. Among European-ancestry defined non-HLA risk loci, six risk loci were significantly associated with type 1 diabetes in subjects of African ancestry. An African-specific GRS provided strong prediction of type 1 diabetes risk (area under the curve 0.871), performing significantly better than a European-based GRS and two polygenic risk scores in independent discovery and validation cohorts. CONCLUSIONS: Genetic risk of type 1 diabetes includes ancestry-specific, disease-associated variants. The GRS developed here provides improved prediction of type 1 diabetes in African-ancestry subjects and a means to identify groups of individuals who would benefit from immune monitoring for early detection of islet autoimmunity.
AssuntosGrupo com Ancestrais do Continente Africano/genética , Diabetes Mellitus Tipo 1/etnologia , Diabetes Mellitus Tipo 1/genética , Testes Genéticos , Antígenos HLA-D/genética , Grupo com Ancestrais do Continente Africano/estatística & dados numéricos , Alelos , Estudos de Casos e Controles , Grupo com Ancestrais do Continente Europeu/genética , Feminino , Predisposição Genética para Doença , Testes Genéticos/métodos , Testes Genéticos/normas , Estudo de Associação Genômica Ampla , Cadeias alfa de HLA-DQ/genética , Cadeias beta de HLA-DQ/genética , Cadeias HLA-DRB1/genética , Haplótipos , Humanos , Masculino , Polimorfismo de Nucleotídeo Único , Valor Preditivo dos Testes , Projetos de Pesquisa , Fatores de Risco
The risk for autoimmunity and subsequently type 1 diabetes is 10-fold higher in children with a first-degree family history of type 1 diabetes (FDR children) than in children in the general population (GP children). We analyzed children with high-risk HLA genotypes (n = 4,573) in the longitudinal TEDDY birth cohort to determine how much of the divergent risk is attributable to genetic enrichment in affected families. Enrichment for susceptible genotypes of multiple type 1 diabetes-associated genes and a novel risk gene, BTNL2, was identified in FDR children compared with GP children. After correction for genetic enrichment, the risks in the FDR and GP children converged but were not identical for multiple islet autoantibodies (hazard ratio [HR] 2.26 [95% CI 1.6-3.02]) and for diabetes (HR 2.92 [95% CI 2.05-4.16]). Convergence varied depending upon the degree of genetic susceptibility. Risks were similar in the highest genetic susceptibility group for multiple islet autoantibodies (14.3% vs .12.7%) and diabetes (4.8% vs. 4.1%) and were up to 5.8-fold divergent for children in the lowest genetic susceptibility group, decreasing incrementally in GP children but not in FDR children. These findings suggest that additional factors enriched within affected families preferentially increase the risk of autoimmunity and type 1 diabetes in lower genetic susceptibility strata.
AssuntosAutoimunidade/fisiologia , Diabetes Mellitus Tipo 1/genética , Diabetes Mellitus Tipo 1/imunologia , Autoanticorpos/imunologia , Autoimunidade/genética , Predisposição Genética para Doença/genética , Genótipo , Antígenos HLA-DQ/genética , Antígenos HLA-DQ/imunologia , Humanos , Ilhotas Pancreáticas/metabolismo , Modelos de Riscos Proporcionais , Fatores de Risco
Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibility genes, with much of the genetic risk now well-defined in youth of Northern European ancestry. The impact of these genetic variants on initiation and progression of the autoimmune process (islet autoimmunity) is now being understood; however, studies are only now being conducted to understand the function of the variants associated with type 1 diabetes risk. The characteristics of genetic risk of type 1 diabetes across the age spectrum suggests extensive complexity in biological and environmental mechanisms. We propose that both genetic and environmental factors attributed to type 1 and type 2 diabetes may contribute to beta-cell death through multiple mechanisms, leading to the clinical outcome of type 1 diabetes.
AssuntosAutoimunidade/genética , Diabetes Mellitus Tipo 1/genética , Diabetes Mellitus Tipo 2/genética , Genoma Humano/genética , Morte Celular/genética , Diabetes Mellitus Tipo 1/patologia , Diabetes Mellitus Tipo 2/patologia , Predisposição Genética para Doença , Humanos , Células Secretoras de Insulina/metabolismo , Células Secretoras de Insulina/patologia , Ilhotas Pancreáticas/metabolismo , Ilhotas Pancreáticas/patologia , Fatores de Risco
Background: Individuals of African ancestry harboring two variant alleles within apolipoprotein L1 ( APOL1 ) are classified with a high-risk (HR) genotype. Adults with an HR genotype have increased risk of focal segmental glomerulosclerosis and chronic kidney disease compared with those with a low-risk (LR) genotype (0 or 1 variants). The role of APOL1 risk genotypes in children with glomerular disease is less well known. Methods: This study characterized 104 African-American children with a glomerular disease by APOL1 genotype in two cohorts: the Chronic Kidney Disease in Children (CKiD) and Nephrotic Syndrome Study Network (NEPTUNE). Results: Among these subjects, 46% had an HR genotype with a similar age at cohort enrollment. For APOL1 HR children, the median age of disease onset was older (CKiD: 4.5 versus 11.5 years for LR versus HR; NEPTUNE: 11 versus 14 years for LR versus HR, respectively) and preterm birth was more common [CKiD: 27 versus 4%; NEPTUNE: 26 versus 12%; combined odds ratio 4.6 (95% confidence interval: 1.4, 15.5)]. Within studies, HR children had lower initial estimated glomerular filtration rate (eGFR) (CKiD: 53 versus 69 mL/min/1.73 m 2 ; NEPTUNE: 74 versus 94 mL/min/1.73 m 2 ). Longitudinal eGFR decline was faster among HR children versus LR (CKiD: -18 versus -8% per year; NEPTUNE: -13 versus -3% per year). Conclusions: Children with an HR genotype in CKiD and NEPTUNE seem to have a more aggressive form of glomerular disease, in part due to a higher prevalence of focal segmental glomerulosclerosis. These consistent findings across independent cohorts suggest a common natural history for children with APOL1 -associated glomerular disease. Further study is needed to determine the generalizability of these findings.
AssuntosApolipoproteína L1/genética , Síndrome Nefrótica/genética , Adolescente , Afro-Americanos/genética , Idade de Início , Criança , Pré-Escolar , Feminino , Estudos de Associação Genética , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Síndrome Nefrótica/patologia , Síndrome Nefrótica/fisiopatologia , Polimorfismo de Nucleotídeo Único , Estudos Prospectivos , Estados Unidos
Background: Two genetic variants in apolipoprotein L1 (APOL1) are associated with increased risk of focal segmental glomerulosclerosis as well as other glomerular phenotypes. These risk variants are common in individuals of African ancestry but absent in other racial groups. Yet, the majority of individuals with two APOL1 risk alleles [high-risk (HR) genotype] do not have renal disease. It is critical to identify environmental and secondary genetic influences that, when combined with these alleles, lead to kidney disease. In a recent study of black children with glomerular disease enrolled in the Nephrotic Syndrome Study Network (NEPTUNE) and Chronic Kidney Disease in Children Study (n = 104), we found that subjects with an HR genotype had a 4.6-fold increase in the odds of preterm birth as compared to those with a low risk (LR) genotype [odds ratio 4.6 (CI 1.4-15.5)]. There are known racial disparities in preterm birth, which itself is a known risk factor for chronic kidney disease and focal segmental glomerulosclerosis. Thus, we questioned whether an HR APOL1 genotype is associated with prematurity in the general African American population. Methods: We analyzed two publically available genetic datasets of preterm birth in African Americans, including 867 infants and 519 mothers from the Gene Environment Association Studies (GENEVA) study of preterm delivery and 960 mothers from the Boston Medical Center genome-wide association study of preterm birth. We performed multivariable analyses testing for association between HR APOL1 and birth outcomes. Results: In both studies, there was no association between HR APOL1 in mothers and prematurity, gestational age or birthweight. Additionally, in the GENEVA study, we saw no association between infant HR APOL1 and prematurity, gestational age or birthweight. Conclusion: From these data, we conclude that the previously observed association between HR APOL1 and prematurity is specific to those with glomerular disease, suggesting prematurity may act as an additional risk factor in APOL1-associated renal disease.
AssuntosAfro-Americanos/genética , Apolipoproteína L1/genética , Variação Genética , Glomerulosclerose Segmentar e Focal/complicações , Nascimento Prematuro/genética , Insuficiência Renal Crônica/complicações , Adulto , Estudos de Casos e Controles , Criança , Feminino , Estudo de Associação Genômica Ampla , Genótipo , Glomerulosclerose Segmentar e Focal/genética , Humanos , Fenótipo , Nascimento Prematuro/diagnóstico , Nascimento Prematuro/etiologia , Insuficiência Renal Crônica/epidemiologia , Insuficiência Renal Crônica/genética , Fatores de Risco , Estados Unidos/epidemiologia , Adulto Jovem
BACKGROUND: More than 30 genes can harbor rare exonic variants sufficient to cause nephrotic syndrome (NS), and the number of genes implicated in monogenic NS continues to grow. However, outside the first year of life, the majority of affected patients, particularly in ancestrally mixed populations, do not have a known monogenic form of NS. Even in those children classified with a monogenic form of NS, there is phenotypic heterogeneity. Thus, we have only discovered a fraction of the heritability of NS-the underlying genetic factors contributing to phenotypic variation. Part of the "missing heritability" for NS has been posited to be explained by patients harboring coding variants across one or more previously implicated NS genes, insufficient to cause NS in a classical Mendelian manner, but that nonetheless have a sufficient impact on protein function to cause disease. However, systematic evaluation in patients with NS for rare or low-frequency risk alleles within single genes, or in combination across genes ("oligogenicity"), has not been reported. To determine whether, compared with a reference population, patients with NS have either a significantly increased burden of protein-altering variants ("risk-alleles"), or a unique combination of them ("oligogenicity"), in a set of 21 genes implicated in Mendelian forms of NS. METHODS: In 303 patients with NS enrolled in the Nephrotic Syndrome Study Network (NEPTUNE), we performed targeted amplification paired with next-generation sequencing of 21 genes implicated in monogenic NS. We created a high-quality variant call set and compared it with a variant call set of the same genes in a reference population composed of 2,535 individuals from phase 3 of the 1000 Genomes Project. We created both a "stringent" and a "relaxed" pathogenicity-filtering pipeline, applied them to both cohorts, and computed the burden of variants in the entire gene set per cohort, the burden of variants in the entire gene set per individual, the burden of variants within a single gene per cohort, and unique combinations of variants across two or more genes per cohort. RESULTS: With few exceptions when using the relaxed filter, and which are likely the result of confounding by population stratification, NS patients did not have a significantly increased burden of variants in Mendelian NS genes in comparison to a reference cohort, nor was there any evidence for oligogenicity. This was true when using both the relaxed and the stringent variant pathogenicity filter. CONCLUSION: In our study, there were no significant differences in the burden or particular combinations of low-frequency or rare protein-altering variants in a previously implicated Mendelian NS genes cohort between North American patients with NS and a reference population. Studies in larger independent cohorts or meta-analyses are needed to assess the generalizability of our discoveries and also address whether there is in fact small but significant enrichment of risk alleles or oligogenicity in NS cases that was undetectable with this current sample size. It is still possible that rare protein-altering variants in these genes, insufficient to cause Mendelian disease, still contribute to NS as risk alleles and/or via oligogenicity. However, we suggest that more accurate bioinformatic analyses and the incorporation of functional assays would be necessary to identify bona fide instances of this form of genetic architecture as a contributor to the heritability of NS.
AssuntosAlelos , Síndrome Nefrótica/genética , Adolescente , Adulto , Idade de Início , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Frequência do Gene , Variação Genética , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Masculino , Pessoa de Meia-Idade , Mutação de Sentido Incorreto , Fenótipo , Valores de Referência , Risco , Adulto Jovem
BACKGROUND: Targeted sequencing of discrete gene sets is a cost effective strategy to screen subjects for monogenic forms of disease. One method to achieve this pairs microfluidic PCR with next generation sequencing. The PCR step of this pipeline creates challenges in accurate variant calling. This includes that most reads targeting a specific exon are duplicates that have been amplified from the PCR step. To reduce false positive variant calls from these experiments, previous studies have used threshold-based filtering of alternative allele depth ratio and manual inspection of the alignments. However even after manual inspection and filtering, many variants fail to be validated via Sanger sequencing. To improve the accuracy of variant calling from these experiments, we are challenged to design a variant filtering strategy that sufficiently models microfluidic PCR-specific issues. RESULTS: We developed an open source variant filtering pipeline, targeted sequencing support vector machine ("tarSVM"), that uses a Support Vector Machine (SVM) and a new score the normalized allele dosage test to identify high quality variants from microfluidic PCR data. tarSVM maximizes training knowledge by selecting variants that are likely true and likely false variants by incorporating knowledge from the 1000 Genomes and the Exome Aggregation Consortium projects. tarSVM improves on previous approaches by synthesizing variant features from the Genome Analysis Toolkit and allele dosage information. We compared the accuracy of tarSVM versus existing variant quality filtering strategies on two cohorts (n = 474 and n = 1152), and validated our method on a third cohort (n = 75). In the first cohort, our method achieved 84.5 % accuracy of predicting whether or not a variant would be validated with Sanger sequencing versus 78.8 % for the second most accurate method. In the second cohort, our method had an accuracy of 73.3 %, versus 61.5 % for the second best method. Finally, our method had a false discovery rate of 5 % for the validation cohort. CONCLUSIONS: tarSVM increases the accuracy of variant calling when using microfluidic PCR based targeted sequencing approaches. This results in higher confidence downstream analyses, and ultimately reduces the costs Sanger validation. Our approach is less labor intensive than existing approaches, and is available as an open source pipeline for read trimming, aligning, variant calling, and variant quality filtering on GitHub at https://github.com/christopher-gillies/TargetSpecificGATKSequencingPipeline .
AssuntosAlelos , Sequenciamento de Nucleotídeos em Larga Escala/métodos , Microfluídica , Software , Máquina de Vetores de Suporte , Confiabilidade dos Dados , Humanos , Reação em Cadeia da Polimerase , Análise de Sequência de DNA/métodos
APOL1 variants have been associated with renal phenotypes in blacks. To refine clinical outcomes and discover mechanisms of APOL1-associated kidney injury, we analyzed clinical and genomic datasets derived from 90 black subjects in the Nephrotic Syndrome Study Network (NEPTUNE), stratified by APOL1 risk genotype. Ninety subjects with proteinuria ≥0.5 g/d were enrolled at first biopsy for primary nephrotic syndrome and followed. Clinical outcomes were determined, and renal histomorphometry and sequencing of Mendelian nephrotic syndrome genes were performed. APOL1 variants were genotyped, and glomerular and tubulointerstitial transcriptomes from protocol renal biopsy cores were analyzed for differential and correlative gene expression. Analyses were performed under the recessive model (high-risk genotype defined by two risk alleles). APOL1 high-risk genotype was significantly associated with a 17 ml/min per 1.73 m(2) lower eGFR and a 69% reduction in the probability of complete remission at any time, independent of histologic diagnosis. Neither APOL1 risk group was enriched for Mendelian mutations. On renal biopsy, high-risk genotype was associated with increased fractional interstitial area, interstitial fibrosis, and tubular atrophy. Risk genotype was not associated with intrarenal APOL1 mRNA expression levels. Differential expression analysis demonstrated an increased steady-state level of five genes associated with the high-risk genotype (CXCL9, CXCL11, and UBD in glomerulus; SNOR14B and MUC13 in tubulointerstitium). APOL1 tubulointerstitial coexpression analysis showed coexpression of APOL1 mRNA levels with a group of intrarenal transcripts that together were associated with increased interstitial fibrosis and tubular atrophy. These data indicate the high-risk APOL1 genotype confers renal risk across histopathologic diagnoses.
AssuntosAfro-Americanos/genética , Apolipoproteínas/genética , Genômica/métodos , Túbulos Renais/patologia , Lipoproteínas HDL/genética , Síndrome Nefrótica/genética , Síndrome Nefrótica/patologia , Adolescente , Adulto , Alelos , Apolipoproteína L1 , Atrofia/genética , Biópsia , Quimiocina CXCL11/genética , Quimiocina CXCL9/genética , Criança , Feminino , Fibrose , Expressão Gênica , Genótipo , Taxa de Filtração Glomerular/genética , Humanos , Glomérulos Renais/fisiopatologia , Túbulos Renais/metabolismo , Túbulos Renais/fisiopatologia , Masculino , Pessoa de Meia-Idade , Mucinas/genética , Síndrome Nefrótica/fisiopatologia , Proteinúria/genética , RNA Mensageiro/metabolismo , Fatores de Risco , Transcriptoma , Ubiquitinas/genética , Adulto Jovem
To maximize clinical benefits of genetic screening of patients with nephrotic syndrome (NS) to diagnose monogenic causes, reliably distinguishing NS-causing variants from the background of rare, noncausal variants prevalent in all genomes is vital. To determine the prevalence of monogenic NS in a North American case cohort while accounting for background prevalence of genetic variation, we sequenced 21 implicated monogenic NS genes in 312 participants from the Nephrotic Syndrome Study Network and 61 putative controls from the 1000 Genomes Project (1000G). These analyses were extended to available sequence data from approximately 2500 subjects from the 1000G. A typical pathogenicity filter identified causal variants for NS in 4.2% of patients and 5.8% of subjects from the 1000G. We devised a more stringent pathogenicity filtering strategy, reducing background prevalence of causal variants to 1.5%. When applying this stringent filter to patients, prevalence of monogenic NS was 2.9%; of these patients, 67% were pediatric, and 44% had FSGS on biopsy. The rate of complete remission did not associate with monogenic classification. Thus, we identified factors contributing to inaccurate monogenic classification of NS and developed a more accurate variant filtering strategy. The prevalence and clinical correlates of monogenic NS in this sporadically affected cohort differ substantially from those reported for patients referred for genetic analysis. Particularly in unselected, population-based cases, considering putative causal variants in known NS genes from a probabilistic rather than a deterministic perspective may be more precise. We also introduce GeneVetter, a web tool for monogenic assessment of rare disease.
AssuntosGenética Populacional , Síndrome Nefrótica/diagnóstico , Síndrome Nefrótica/genética , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Humanos , Pessoa de Meia-Idade , Adulto Jovem
UNLABELLED: When performing DNA sequencing to diagnose affected individuals with monogenic forms of rare diseases, accurate attribution of causality to detected variants is imperative but imperfect. Even if a gene has variants already known to cause a disease, rare disruptive variants predicted to be causal are not always so, mainly due to imperfect ability to predict the pathogenicity of variants. Existing population-scale sequence resources such as 1000 Genomes are useful to quantify the 'background prevalence' of an unaffected individual being falsely predicted to carry causal variants. We developed GeneVetter to allow users to quantify the 'background prevalence' of subjects with predicted causal variants within specific genes under user-specified filtering parameters. GeneVetter helps quantify uncertainty in monogenic diagnosis and design genetic studies with support for power and sample size calculations for specific genes with specific filtering criteria. GeneVetter also allows users to analyze their own sequence data without sending genotype information over the Internet. Overall, GeneVetter is an interactive web tool that facilitates quantifying and accounting for the background prevalence of predicted pathogenic variants in a population. AVAILABILITY AND IMPLEMENTATION: GeneVetter is available at http://genevetter.org/ CONTACT: firstname.lastname@example.com or email@example.com SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.


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Clausen Hi-Leg Recliner DarHome Co
Your dining room should be more than only a spot to have a meal and go. It's a chance for you to wow your guests, it's a location where you can sit and relax, it is a place for the children to do their homework, and so much more. It is important that you opt for the very best Clausen Hi-Leg Recliner to make certain you are comfortable and the area looks beautiful. When deciding upon the best furniture, you want to think about how comfortable you'll feel as you have your dinner, whether the seat will have the ability to resist your own weight, if it will be easy to move around and how durable they are. Aesthetics too play a major part in deciding what to select. We have taken the various features into account and accumulated expert opinions to think of the best 10 finest Clausen Hi-Leg Recliner brands in 2019and that is our list below.
Product Desciption
Why settle for a club chair when you can enjoy a recliner? This versatile, clean-lined recliner has high-leg styling and sits comfortably low to the ground, nice padded round arms, and enhanced seat cushion with pocket coils in the seat for added support.
- Upholstery Material: Polyester Blend
- Upholstery Material Details: 73% Polyester and 27% acrylic
- Weight Capacity: 275 lb.
- Assembly Required: Yes
List Of The Best lounge chairs In 2019
1. Rucinski Power Lift Assist Recliner Red Barrel Studio
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Product Description :
Ultra plush living room recliner power lift chair is allowing effortless rise from sitting position. Reclining and lifting mechanism can be controlled by an attached remote control - This recliner is powered by a silent motor. The chair is upholstered in a super soft and comfortable bonded leather. Designed to fully recline and provide ultimate comfort.
- Upholstery Material: Faux leather
- Upholstery Material Details: Bonded leather
- Weight Capacity: 350 lb.
- Assembly Required: Yes
- Product Warranty: 1 Year
When it comes to buying living room furniture, leather is definitely a smart option. It doesn't only look great with most styles, nevertheless its very durable (its the perfect materials for a home with kids or pets) and it is ultra-simple to thoroughly clean, too. The downside of leather furniture? It can have a higher price tag than fabric, microfiber or faux leather furniture. This lying loveseat stays a budget-pleasant choice due to 1 guru trick: its sitting area is padded with leather, as the attributes are upholstered with increased inexpensive faux leather. Which means you get the appear and feel of a full leather loveseat with no hefty cost. Use the lever around the loveseats equip to kick back and take it easy on its higher-denseness foam filling, and think about all the money held on. This particular loveseat comes with an additional bonus: professional assembly is available in numerous areas of the nation for an additional charge.
2. Arno Chaise Lounge Laurel Foundry Modern Farmhouse
Read more about Arno Chaise Lounge Laurel Foundry Modern Farmhouse
Product Description :
Providing a platform to perch with a well-thumbed novel or lending an eye-catching accent to your living room look or master suite ensemble, chaise lounges are stylish and versatile additions to any abode. Take this one for example: Made in the USA, it���__s crafted from a solid pinewood frame and features four legs awash in a dark brown coloring. Up top, it showcases solid-toned, foam-filled upholstery for a look that easily complements any color palette.
- Upholstery Material: Polyester Blend
- Frame Material: Solid Wood
- Orientation: Left-Arm Chaise
- Seat Fill Material: Foam; Polyester
- Weight Capacity: 350 lb.
Although this lying loveseat comes with a heftier cost, its classic design, choices for personalization and automatic reclining program allow it to be well worth the dough. Its hand made wood body is cushioned with down blend soft cushions for any much softer really feel than you would get from high-density froth soft cushions, and also the upholstery will come in a whopping 72 colour and material combinations. The supply of a lot of options makes it extra easy to set this lying loveseat with various designs, materials, accents and decorations designs. Plus, for those who have kids or pets (or each!), you have the option to choose a more durable, stain-resistant material. 1 customer shared the Sunbrella canvas materials has held up well towards her children and pets. This lying loveseat may have a classic, old-school appear, but its built-in technology is not. It doesn't only have an automated lying system (that will give you a full lie down, with your foot rest totally similar to the seat), but it has a Universal serial bus interface for implementing or simply getting your iPad, apple iphone, Kindle or laptop computer.
3. Magoon Traditional Upholstered Reclining Loveseat Red Barrel Studio
Read more about Magoon Traditional Upholstered Reclining Loveseat Red Barrel Studio
Product Description :
Kick your shoes off and lay back in this absolutely comfortable love seat featuring 2 recliners for the utmost comfort. This loveseat enhances the look of your living space. Crafted from fabric and metal, this loveseat features plush arms, creating a relaxing armrest and a tufted design that gives it a dash of elegance. Also, the manual lever at its side helps you too set it to any comfortable position.
- Upholstery Material: Fabric
- Design: Reclining
- Overall Product Weight: 128.7 lb.
- Assembly Required: Yes
- Overall: 37'' W x 60'' D
This group of RTA couches comes in different furniture textures. Some of them include bonded leather, linen, corduroy, bed linen texture, polyester. You just need to choose the right tapestry in importance for your balanced needs. Accessible materials offer an simple-to-clean element. A attribute that suggests its versatility to resist food and drinks. The luxurious seat and back again soft cushions vote in favor of a reducing-edge look. The square shaped equip that starts just over them improves the elegance. You will find the comforts and soft styles that strike your entry.
4. Wellersburg Reclining Configurable Living Room Set DarHome Co
Read more about Wellersburg Reclining Configurable Living Room Set DarHome Co
Product Description :
Cushioned to perfection, this reclining sofa offers comfort and utility. The recliner design utilizes heavy duty Centro mechanisms to ensure long-lasting usage while the center seat back drops down to provide convenience with its duo cup holders. The gray bonded leather accentuates the foam-filled design and draws attention to the stylish appeal.
- Upholstery Material: Faux leather
This set accompanies the entire utility of Person Sofa with an exemplary sofa design. It incorporates restricted hands, firm chair cushions and complete-size mat with internal comes. It's eliminated beneath to clean it and remove it having a easy raising instrument. This sleeping pad is reinforced with a durable steel advantage. is a calculating rule and it has a Bi-falling apart emphasize. One of the worthy items to point out is the convenience! Location this super comfortable sofa inside your comfortable family room. Apart from providing an all natural and tasteful atmosphere, it gives an attractive character for your visitors. You may make your companions remain for a fun nights films. The sofa has carcasses with obstructed corners and faux-completing on its legs. The cushions are, nevertheless, adjusted and include excellent versatility. It is covered with a heavy polyethylene dietary fiber having a drawstring advantage.
5. Fergstein Reclining Configurable Living Room Set Hokku Designs
Read more about Fergstein Reclining Configurable Living Room Set Hokku Designs
Product Description :
Casual and comfortable, this plush sofa is a convenient addition to any living space. Chenille fabric to match any traditional d��cor. Side seats recline easily with a simple pull on either side's latch.
- Upholstery Material: Chenille
This set features a one remaining equip couch set, two armless couch models and one part couch established. This gives enough room to accommodate your friends and relations. The material is 100Percent polyester for enough comfort and durability. The good thing about this sofa established is the mixing and matching of seats within the available space within the room for any perfect shape. As well as enables fitted even in small areas. It requires just light putting together.Additionally, it functions drive soft cushions for maximum comfort. You might want to do this set. It does the job nicely.
6. Parsons Chair Offex
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Product Description :
This Parsons Chair will add contemporary sophistication to your dining room or living room. This chair can be used as an accent chair around the home when giving your home a more decorative appeal. The European designed side chair features leather upholstery, while the frame and legs are constructed of solid wood.
- Main Material: Upholstered
- Main Material Details: Bonded leather
- Weight Capacity: 250 lb.
- Seat Height - Floor to Seat: 20.5 ''
This extremely-stylish, high-sovereign sofa is made to support reducing-edge lounge innovation. It's created as a 2-item sectional couch combined with an attractive lounger. Additionally, it offers cellular arm rests and beneficial back again assistance. The beautiful tapestry is finished with darkish false leather-based, securely tufted. You are able to feel at ease padding with froth within the seat cushions. This ensures a delicate feeling when you rest following a boring day time. The sofa is reinforced with wooden edge covered with dark synthetic leather. False tufted leather-based and strong pinus radiata give extreme glare. It is a fact that it takes a second appear because it is more costly than it really seems to be. Speaking of dimension, its huge! This is exactly what adds much more superstars for this established. The height is also impressive for tall and short individuals.
7. Lexington Manual Swivel Recliner Red Barrel Studio
Read more about Lexington Manual Swivel Recliner Red Barrel Studio
Product Description :
- Upholstery Material: Faux leather
- Upholstery Material Details: PU Leather
- Reclining Type: Manual
- Weight Capacity: 450 lb.
- Assembly Required: Yes
This extremely-elegant, higher-sovereign sofa is made to support cutting-advantage lounge innovation. It's created like a 2-item sectional couch coupled with an attractive lounger. Additionally, it provides mobile arm rests and advantageous back assistance. The beautiful tapestry is completed with darkish false leather, firmly tufted. You can feel comfortable cushioning with foam within the seat soft cushions. This ensures a delicate feeling when you rest after a monotonous day time. The couch is strengthened with wooden edge covered with darkish artificial leather-based. False tufted leather-based and powerful pinus radiata give extreme glare. It is true that it takes a second appear because it is more expensive of computer truly seems to be. Speaking of dimension, its large! This is exactly what provides much more stars to this established. The peak is also impressive for tall and short individuals.
8. Bouirou Papasan Chair World Menagerie
Read more about Bouirou Papasan Chair World Menagerie
Product Description :
Snuggle up together to enjoy a great movie on Bouirou Papasan Chair. Made with a rattan frame in a dark wood finish, this cozy design features a deep-padded, tufted cushion that invites you to sink into its comfort for relaxing down time. A lacquer finish accentuates the natural beauty of the rattan bowl and base, while the polyester blend upholstery sports global-inspired patterns for a worldly look. Establish a curated aesthetic in your living room by rolling out a soft ogee area rug to...
- Upholstery Material: Polyester Blend
- Upholstery Material Details: Rattan
- Assembly Required: No
- Removable Cushions: Yes
- Weight Capacity: 250 lb.
English folded arm couches are extra comfortable because of the large, pillows behind and for the chairs. Reduced hands are comfy for lying down and also the exposed legs keep this sofa style from sensation too heavy or impacting. It actually came from in the change of the hundred years and can be associated with something typical of the British countryside. Distinguishing characteristics generally include low uncovered thighs, gentle, generous cushions, a tight back again and recessed hands. Though it may be regarded as a vintage design, it's also a perfect accessory for a contemporary room because of its comfy and flexible look.
9. Wayne Wingback Chair DarHome Co
Read more about Wayne Wingback Chair DarHome Co
Product Description :
The Chippendale Wingback Chair is proudly handcrafted in the USA and features a solid hardwood frame, drop-in coil suspension system which offers superior comfort and stability, and welting on all seams. Timeless Chippendale Style Solid Wood Base and durable, luxurious microfiber with the look and feel of velvet without wrinkles or crushing provide many years of enjoyment.
- Upholstery Material: Polyester Blend
- Assembly Required: No
- Removable Cushions: Yes
- Weight Capacity: 250 lb.
If youre looking for some serious relaxation, this loveseats strong pillow back and folded arms will deliverbut at a higher price tag. Each chair cushion consists of 30 person pocketed circles for springtime and assistance, and resilience chair froth for an extra layer of plushness and durability. In addition, the froth cushions are topped with super gentle, blended lower down. For the extra comfort and ease, there are 3 standard positions: sitting, a slight lie down with an elevated footrest, and a complete lie down with an elevated foot rest. It doesnt harm this lying loveseat looks lux, possibly. Its all-leather upholstery and ornamental toe nail mind cut provide a classic appear that may work with lots of home decorations styles, from traditional to nation to arts and crafts. Plus, leather-based stands up well against daily use, children and pet locks and nails. Just be sure you situation the leather-based every 6 to 12 months.
10. Showcase Reclining Sofa Southern Motion
Read more about Showcase Reclining Sofa Southern Motion
Product Description :
The Showcase introduction from Southern motion puts the spotlight on some of their most successful elements from over the years but with innovative updates combined into a hot, fresh design. Dramatically flared radius arms are hand-upholstered in the USA. Poly-foam padding provides soft support while allowing such sleek shaping. Single needle French seams outline the different elements making them inchpopinch just that much more. Notice the seams that start on the outside front of the arms and are...
- Upholstery Material: Polyester Blend
- Design: Reclining
- Assembly Required: No
- Overall: 88'' W x 40'' D
If youre searching for some severe relaxation, this loveseats solid cushion back again and rolled hands will deliverbut at a higher cost. Each chair cushioning contains 30 person pocketed circles for spring and assistance, and high strength chair foam for an extra layer of plushness and sturdiness. In addition, the foam cushions are capped with extremely soft, combined lower feathers. For the additional comfort and ease, you will find 3 regular positions: sitting, a small lie down by having an raised footrest, and a full recline with an raised foot rest. It does not harm that this lying loveseat looks lux, either. Its all-leather-based furniture and decorative toe nail head trim provide a classic look that can work with lots of house dcor designs, from conventional to country to crafts and arts. Plus, leather stands up nicely towards daily use, children and pet locks and nails. Just remember to condition the leather-based every six to twelve months.
Where to Find Clausen Hi-Leg Recliner
You might think you could get the exact same quality of furniture in your Big Box stores but that's not the situation. Put simply, you don't find high-end clothes & apparel at JC Penny. {You would have to really go to Dolce & Gabanna or Neiman Marcus for this.
Keep in mind, even forgetting to work in your operating plan, you'd rather not go all due to a cheap coffee table that is excessively expensive. Do not try to be an indiscrete buyer who buys out of the sensation a smart buyer who buys with due thought to the above mentioned things and you are planning to even integrate other furniture.

subset: commoncrawl


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Timeless Grace Navy Multi Floral Print Dress
One And Only Collective
Fit: This dress runs true to size and has a slight fit and flare silhouette.
Length: The dress measures approximately 35" and hits at mid thigh.
Bust: The bust is fitted and provides full coverage.
Waist: The waist is fitted.
Hips: The hips are skimming.
Undergarments: This dress is bra friendly.
Fabric: The fabric contains no stretch.
London Drake
Size: 2
Height: 5'8"
Bust: 32D
Waist: 25
Hips: 36


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More and more companies are outsourcing their marketing efforts, and telemarketing is one of them. As a freelance telemarketer working from home, you will be setting appointments with customers and creating warm leads for companies. The amount you charge will depend on the size of the company you are working for, and the project they want to allocate you.
LLCs have fewer ongoing requirements compared to their corporation counterparts. For example, an LLC is not required to keep minutes or hold annual meetings. An LLC also does not have a board of directors, and isn't is held to the same record keeping standards of a corporation. Keep in mind that the state of incorporation in will have its own set of annual requirements. That includes filing the required business licenses and permits, which vary from state to state. Be sure to check in with your Secretary of State to ensure you don't accidentally miss any required filings.
Despite being a relatively new option, the limited liability company (LLC) is now one of the most popular business structures among smaller organizations. While allowing business owners to remain free from a great deal of the regulations imposed on other types of companies, it still provides limited liability protection for its owners (members). This means that the personal assets of an LLC's ownership cannot be collected to fulfill the debts of the business.
The wedding industry is one that will most likely live in perpetuity. This is meant to be a special day for a couple, but often turns into a chore because of all the planning that comes with it. Because it is nearly impossible for brides and grooms to be able to enjoy the planning of their wedding, they often pay professionals to do it for them. If you have strong organizational skills, are communicative, pay attention to the little details, and love weddings, then you could set up shop from the comforts of your home. To get started and build a portfolio, offer your services to a friend or family member. From there, you can start charging other clients.
Tennessee "corporation", "incorporated", "company", or the abbreviation "corp.", "inc.", "co.", or words or abbreviations of like import in another language (provided they are written in Roman characters or letters); existing corporations which were formed using only "limited" or "ltd" are not required to change their name § 48-14-101 Tennessee Code
Since renewable energy startup ideas require significant capital, most of the renewable energy operations are supported by large companies, such as Pacific Power in the Northwest. Adopting the latest technologies such as mobility, software solutions, BI & big data, machine learning algorithms, sensors, and IoT solutions could take the renewable energy business or smart energy startups to next level.
Unltd or Ultd (Unlimited/無限公司): similar to a limited liability company (Ltd) but whose members or shareholders do not benefit from limited liability should the company ever go into formal liquidation. It is not a requirement under company law to add or state the word or designation Unlimited (無限公司) or its abbreviations (Unltd or Ultd) at the ending of its legal company name, and most unlimited companies do not.
The law specifies that all taxable personal property must be assessed as of a specific point in time, and that point is precisely at 12:01 a.m. January 1 (regardless of what transpires after that date). Even if closed shortly after the lien date, a business must still file a Business Property Statement and pay taxes for the coming fiscal year on any taxable property they owned on the lien date.


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Blood on head of penis. Causes of penile cancer
Even if you have no other symptoms, blood coming from your penis can be alarming. Reasons for bleeding from the penis can range from an especially vigorous workout to more serious medical conditions. In some cases, the presence of other symptoms can help narrow down possible causes. Your doctor will do some testing to determine the underlying cause of your condition and make a diagnosis. The penis has two main jobs.
Read on to learn more about what can cause a cut on your penis, how these causes are treated, when you should see a doctor, and how to prevent penis cuts. How to Heas Asleep in 10, 60, or Seconds. Od noticed a slight rash under his foreskin and went to his GP because Blood on head of penis did not clear up. If you experience any symptoms of penile conditions, contact your doctor. Most cases of fractured penis caused by sex and most other minor penile wounds will heal without problems if treated at once. Related Resources. These items can cause lasting damage to the penis if the blood flow is blocked for too long.
Blood on head of penis. RECENTLY ADDED
Those symptoms include:. But for me, getting Botox is the…. An ultrasound or a CT scan may be used oof view the size, shape, and health of the prostate. And eventually I got a Whether you have surgery, radiation or hormone therapy, you are likely to have side effects. Two penile conditions, priapism and paraphimosis, often require emergency medical treatment.
Penile conditions have varying signs and symptoms.
- Any change in the appearance of your penis can be cause for concern.
- Tom over a year ago.
- If you think you may have a medical emergency, call your doctor or immediately.
Back to Health A to Z. It most commonly affects men over Free kive webcams age of If Blood on head of penis experience these symptoms, it's important to see your GP as soon as possible. The cause of penile cancer isn't known, but certain risk factors can increase your chances of getting it, including:. Your GP will ask you about any symptoms you have and when they occur. They'll also examine your heac for signs of penile cancer.
To find out if you should be referred for further tests for Blood penile cancer, heead the NICE guidelines on Suspected Cancer: Recognition and Referral. This is usually a urologist, a doctor who specialises in conditions that affect the urinary system and genitals. They may also check for any physical signs of penile cancer. A blood test may be carried out to check your general health and number of blood cells. To confirm Blood on head of penis diagnosis of penile cancer, you may need to have a biopsy.
In most cases, any physical changes to your penis after an operation can be corrected with reconstructive surgery. But with early diagnosis and modern surgical techniques, Big tatoo boobs surgeon will usually be able to preserve as much penile tissue as possible. As part of most treatments for penile yead, the lymph glands small organs that are part of the immune system in the groin will be assessed to determine if the cancer has spread.
As with most types of cancer, the outlook for individual cases depends largely on how far the cancer has advanced at the time of diagnosis. It isn't always possible to prevent penile cancer, but you can reduce your chances of getting it.
This is easier if you were circumcised as a child, but there are steps you can take if you haven't been circumcised. There's little evidence to suggest that being circumcised as an adult will reduce your chances of developing penile cancer. Read more about penis health. Page last reviewed: 4 October Next review due: 4 October Penile cancer.
Any delay in diagnosing penile cancer could reduce the chances of successful treatment. Diagnosing penile cancer Your GP will ask you about any symptoms you have and when Blood on head of penis occur. The main treatments for later-stage penile cancer are: surgery radiotherapy chemotherapy Surgery involves removing the cancerous cells and possibly some of the surrounding tissue. Skin and muscle can be Dating someone younder than you from elsewhere in the body to recreate a functioning penis.
In some cases, the lymph glands may need to be surgically removed. Want to know more? Preventing penile cancer It isn't always possible to prevent penile cancer, but you can reduce your chances of getting it.
Jan 23, · My penis has turned a red/purplish color on the head. The scrotum can also be a little red. There are no sores or anything, but it was a bit itchy. It showed up a few days after sex. Any ideas what th read more. blood on head of penis. i was changing my babies diaper and i was cleaning him up and noticed he had blood coming from the head of his penis i checked his diaper and there was none there what could it be?can it be a uti????? Anonymous Asked 9/23/07 Answer this question. Red blood type spots on penis head watch. Each papule looks like a tiny flesh coloured dome and they are usually located around the corona of the glans penis. The glans is that portion of the penis that is covered by the foreskin and the corona is the area just below the glans. In other words if we consider the glans to be the head.
Blood on head of penis. How Does the Penis Normally Work?
But if that doesn't work, here are six other hacks to try. If you treat cancer of the penis before it spreads into the deep tissue, you'll reduce your risk of needing a penectomy surgery to remove part of or the entire penis. In this case, the urethra acts as a channel for semen to be ejaculated into the vagina. If you experience blood in your urine your doctor will carry out a urine dipstick test initially and if confirmed then look for a underlying cause — ie if it's a simple infection they will prescribe antibiotics. Symptoms of penile cancer - Penile cancer can cause growths or sores on your penis, bleeding on or from your penis and an abnormal discharge from your penis, among other symptoms. It can be wounded as a result of: car accidents machine accidents gunshot wounds burns sex sports The penis is most often hurt during sex. Marathon runners and other athletes who engage in extreme workouts can sometimes find blood in their urine. In some cases, all you can do is drink plenty of fluids and wait for the stone to pass. For patients on anticoagulation drugs such as warfarin , passing blood can mean the drug is not working properly. STDs such as chlamydia can also cause you to have a discharge from your penis. If your doctor suspects prostate cancer, they may recommend a prostate biopsy, in which a tissue sample is taken from the prostate gland. Penile discharge explained. Kidney health. And if you scratch itchy spots on your penis too often or too hard, you can tear open the skin. While some of the earliest signs can be a mere irritation, they can become extremely painful.
A cut is usually nothing to worry about.
The ultimate nightmare: you glance at your manhood while undressing for bed and then you see it. A dark red bump on the tip of your shaft. Immediately, your thoughts spiral. Is it an STD? Could it be cancerous?


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THE FIRST LOOK AND TITLE OF BIGG BOSS 2 STARS' NEXT IS HEREHome > Tamil Movies > Tamil Cinema News
By Aravind | Aug 21, 2019 09:27 PM
Actor Mahat Raghavendra was formerly known for his participation in the second season of the widely watched Tamil reality show Bigg Boss 3, which was aired on 2018 and hosted by multi-faceted film personality Kamal Haasan. The season was won by actress Riythvika.
Mahat had also acted in Tamil films such as Mankatha, Anbanavan Asaradhavan Adangadhavan and Chennai 600028 II. For his upcoming film, titled Ivan Than Uthaman, Mahat is paired with another former Bigg Boss 2 contestant Yashika Aanannd. The film's first look was launched recently.
Ivan Than Utthaman is written and directed by Magven and features songs and background score composed by SS Thaman. The cinematography is handled by Sooraj Nallusami and this venture is bankrolled by R.V. Bharathan under the banner Bharathan Pictures.
Finally Here is the title of my first solo movie! Need all your love and blessings 😇❤ #mahatyashikacombo #ivandhanuthaman
#MagVen @MahatOfficial @iamyashikaanand @iamvenkat6 @mahiram20 @MusicThaman @VigneshShivN @onlynikil @manobalam
#Omsairam pic.twitter.com/7l8Er6msRS— Mahat Raghavendra (@MahatOfficial) August 21, 2019
It is noted that popular actor, screenwriter and director Vignesh Shivan is also working as a lyricist in this film. Apart from that, Yashika Aannand will also be next seen in the horror-comedy Zombie which stars Yogi Babu and Youtube sensations Gopi and Sudhakar.


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With Wingman, there's no need for any more embarrassing blind dates. This also means if things don't go well at first, your friend never has to know about their online dating fail and can simply look for more fish in the sea. The app is free to download, and you need to verify yourself as a wingman to get your friend set up. It went live in 2017 and is currently available for both Android and iOS. However, there isn't a desktop version.
In addition, if you're casually dating someone and then have the desire to take things to the next level, it can be hard for you to transition your casual connection to that of a committed relationship, as the person you're dating may not be looking for anything serious. Along these lines, people may also find themselves longing for the deep connection, intimacy and closeness that an exclusive and monogamous relationship can bring. In fact, it's not uncommon to feel emotionally unfulfilled when you're casually dating.
Have you ever crossed paths with a stranger and felt an immediate connection? Have you always regretted not introducing yourself to that cute guy in the elevator or that really funny waitress? Happn is a dating app that gives you a second chance with missed connections. Every time you cross paths with another person who has the app on their phone, you'll be able to view their dating profile. You can also see how many times you've crossed paths with a person and if you don't want to match with them, you can simply remove that profile from your timeline. If you've found someone you'd like to get to know more you can like them with the app's heart button, and if the feeling is mutual, you'll be able to message back and forth.
Why it's awesome: Founded in 2000 by Dr. Neil Clark Warren, eharmony is the site for serious daters. A spokesperson for the site says it's been used by 54 million people, and is apparently responsible for 4 percent of U.S. marriages. Users answer a lengthy questionnaire that helps eharmony determine what it calls a "a select group of compatible matches with whom you can build a quality relationship." Spira says she's always seen eharmony as a "matrimonial dating site.""That doesn't mean you're going to walk down the aisle, but it certainly means that you're looking for a very serious relationship that may or may not lead to marriage. It may lead to living together or at least being in an exclusive, committed relationship."
I've had a pleasant experience chatting with a real, flesh-and-blood Ukrainian woman once. That was during my sightseeing tour around Kiev three years ago. The impression these ladies make on you is so different that I can't even describe it. Once I came across this service, I thought maybe I could get the same experience. While not as pretty as in real life, Ukrainian girls are still fascinating.
The app is free and there is no desktop version. You can purchase credits separately in the app or pay monthly for the premium version, which lacks any ads and lets you see who has liked you, among other features. It has 4.2 out of 5 stars in the Apple app store, and some user reviews note the app can be very confusing in busy urban areas, like New York City. We're guessing it's also not very effective in less populated rural areas, as it relies on a lot of people having the app on their phone. You can also play the app's built-in game CrushTime, which lets you guess who has liked you from four profiles you've recently crossed paths with.
You can join this site by connecting with either your email or social media account. When you join, you are supposed to create a good profile that will attract people. You will be given a trial period before you starting paying for the services. The good thing is that it comes with an area code identification feature and only the people from within your locality shall be revealed to you. On this site, it will be easy for to meet your match since you will only be connected to the people around you.
Ultimately, narrowing down all of the dating sites out there comes down to which ones receive the best user and company reviews. Listening to singles about their experiences and testing out the numerous options ourselves are the two biggest components that make up our reviews. And through all of our research, we've determined that Match truly is the top choice for any type of dater, while Zoosk is great for dating on the go.
There's also a user feed feature in the app that's similar to Facebook. Along with a dating profile, users post information about their day-to-day lives, likes and dislikes. One of the app's most unique features is its "relationship mode," which you can turn on to let other users know you're only looking for friendship, not a date. Take note, though: The app's 3.9 out of 5 star App Store rating (as of December 2018) is far from perfect. As such, the app might not be for everyone. It also has a 2.5 star rating in Google Play, with users noting glitches in the interface. In addition, you have to pay for some features, and some people didn't like that they only found that out after downloading the app. That aside, HER is a safe online community for queer woman to connect.
We created three made-up online dating profiles and spent five days trying out each service and monitoring the responses our fake profiles received. We created a woman seeking a man, a man seeking a woman and a woman seeking a woman to make sure our data was well-rounded. All three profiles were similarly generic: They were white with bachelor's degrees with low to midrange full-time jobs. To create these accounts we had to make fake email accounts and, for some sites, fake Facebook accounts and phone numbers as well.
OkCupid has as many downsides as Tinder, and fewer positive ones, with the exception of learning a lot more about your potential dating partners. The interface is extremely clunky and the photos are a little small. You also have to tap on a user's small image to see a larger version and the person's profile, which is simply too large for an app. It works on a website, but it's overkill on an app, and the amount of scrolling required makes it annoying to access. When you exit back to the list, there's no guarantee that it'll be in the same order or that it will return you to the spot you scrolled down to, making it extremely hard to keep track of what you've already viewed.
I dated a French guy who slept with me asap. Was hideously romantic, chased and chased, swept me off my feet, told me he loved me … and then ran for the hills when I made a comment suggesting he was my boyfriend after a few months. He then started to play games and get all 'come here, no go away, no come here' with me. Ended up breaking my heart and my sanity.
11. European men don't play games. Nor will they freak out when discussions of commitment or future come up. Americans (both men and women) have been socialized to play games, to act unavailable, to wait a particular amount of time before texting back… There are a set of ritualized rules that are abided by in American dating culture, and if you don't play within them, you are labeled as desperate or needy or undesirable.
If you're new to online dating, you aren't alone. Around 49 million singles have tried online dating at some point in their lives. With an estimated 7,500 online dating sites in existence, it can be hard to determine which site is the best for helping you find love. Think about what you're looking for in a relationship, whether you just want to meet some fun people or you're looking to settle down, to narrow down your choices and pick a dating site that can help you with your goals. Spend some time on your dating profile to make sure you're getting accurate matches. If you want a more personal approach to finding matches than online dating provides, consider enlisting the help of a professional matchmaker.
Experts Say: Are you a single, successful millionaire looking for someone suitable to date? The truth of life is the more successful and rich you are, it is harder to find someone genuine to date who is interested in you and not your possession. It is easy to find gold diggers to date but expecting a serious, steady and long-term relationship is not possible. If you are rich and successful but single, join the elite millionaire dating site in UK Millionaire Match. It is the best online site to find someone who is millionaire her or himself and as successful as you are. This is the right place to find a steady and long-term partner interested in dating a millionaire being rich themselves....
The end of fake profiles, catfishing, or ghosting. AND that's not even the best part. Their experts screen for young, intellectual and exciting individuals so you can ensure you've got a high calibre of fun young professionals on the app. Because let's face it, who wants to waste 5-months of texting someone only to find out they are still looking for a first job, 5-years after graduating. High quality, high compatibility – end of. Sign up now to see if you make the CUT.
Why it's awesome: Plenty of Fish, sometime styled as POF, boasts 4 million daily active users, with 65,000 new users each day, apparently, and claims users send 1 billion messages per month. After registering for POF, hopeful daters take a personality test that then helps POF determine what they call, "Your Relationship Needs." Basically, it's a way to make sure users know what they want from their love lives, and to ensure that it serves users other profiles that meet that criteria. One unusual quirk: The site recently launched a feature that allows users to message others through Google Home. Says Spira: "They have a large user base, are a free site, and are very popular."
VIDA is your very own team of experts who set up high-quality dates for you so you can finally meet your ideal woman. Say goodbye to the hassle and frustration of online dating - we'll craft an irresistible dating profile, send engaging messages, and even book your dates for you. Thousands of guys have already made lasting connections with beautiful women, and we're ready to make you our next success story. All you need to do is schedule your free confidential consultation with us now.
Die Casual-Dating Plattformen der Ideo-Labs sprießen derzeit nur so aus dem Boden. Nach dateformore, daily-date, just-date, only-date und click-and-date dürfen wir uns nun über lol-date und Wow-date freuen. Doch Verbraucherzentralen sind sich einig: Bei den genannten Portalen handelt es sich um eine Abofalle. In diesem Beitrag, erfährst du, wie du Wow-Date kündigen und der Abofalle wieder entkommen kannst.


text: \n\u201cTrial runs on Phase 1B have been completed and approval from the chief commissioner of Rail Safety (CCRS) is likely to be received shortly,\u201d Jaipur Metro Rail managing director, Mr Mukesh Kumar Singhal, told IRJ. \u201cThe line will become operational by March.\u201d\n\n\n\nWhen open, the line will provide a link\nto historic sites such as Jantar Mantar and the City Palace.\n\n\n\nWhile the 9.63km Mansarovar - Chandpole Phase 1A section of Line 1, built at a cost of Rs 27bn ($US 377.6m), has been open since 2015, the 2.4km Phase 1B extension suffered cost and time overruns because of opposition from conservationists and shopkeepers residing in the crowded areas of Choti Choupar and Bari Chopuar.\n\n\n\nThe line has been completed at a cost\nof Rs 11bn. Civil works were undertaken by the Taiwanese Continental\nEngineering Corporation, while Alstom provided the tracks and signalling\nsystems. Public sector undertaking Bharat Earth Movers Limited (BEML) supplied\n10 trains.\n\n\n\nLine 1 currently operates 170\ntrains a day using a fleet of four-car trains. Ridership of 25,000 passengers\/day\nis far below the target ridership figure of 100,000. \u201cBut, after the linkage to\nOld Jaipur is provided for, the ridership figures will spiral exponentially,\u201d\nSinghal predicted.\n\n\n\nMeanwhile, Phase 2 remains stuck in\nprocedural issues, as an updated feasibility study has been launched, with a new\ndetailed project report (DPR) from Egis Rail expected sometime this year.\n\n\n\nAccording to the original DPR, a 24km\nline was proposed from Sitapura to Ambawadi at an estimated cost of Rs 1 trillion.\nSinghal says the cost is likely to be scaled back in accordance with the state\ngovernment\u2019s new focus on cost-cutting.\n\n\n\nAt a meeting in New Delhi last\nweek, officials from the Delhi Metro Rail Corporation (DMRC), who are acting as\nproject consultants, are understood to have told Jaipur metro officials that\noptions such as trolleybuses and rubber-tyred metro cars could be considered\nfor Phase 2.\n\n\n\nWhile Phase 1 will meet its 2020\ncommissioning targets, Phase 2 is nowhere near meeting its completion timeline\nof 2021. The delay has largely been caused by the previous state government, headed\nby the Bhartiya Janata Party (BJP), deciding to undertake the task under a public-private\npartnership (PPP), instead of the usual method of building metro lines on a\n50:50 cost sharing basis between the central and state governments.\n\n\n\nFollowing a change of government in\nNovember last year, the state is likely to revert to the 50:50 cost sharing\nmodel, an official said, and seek central government funding for Phase 2.\n\n\n\nFor detailed information on metro projects around the world, subscribe to IRJ Pro. \n


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Crystal Queen – Popular Video Slot
All About Crystal Queen
The background of the Crystal Queen game is in fact totally covered in snow, with little to no details visible. This landscape will change and turn into a green prairie covered in grass and flowers during the Free Spins. The graphics of Crystal Queen are more than decent, if not exceptional, and the soundtrack and sound effects are also of good quality.
Betting Options
Crystal Queen is reminiscent of Disney's Frozen movie and has 5 reels and up to 56 paylines (with up to 6 rows). There are 2 wild symbols with a Spreading Wild which rewards you with up to 5 additional and adjacent wilds when it appears. It has the Swooping Reels feature throughout where you can win time and time again from every spin – the multiplier increases up to 5x with more rows available for consecutive wins. There's also a Free Spins Bonus feature where you will get 10 free spins, all 56 paylines/6 rows enabled and Both Ways Wins too! Crystal Queen is brought to you by Quickspin and is based on the Danish author Hans Christian Andersen's story about the Snow Queen.
Special Features
You will begin with a classic 5×3 setup, with five reels containing three symbols each. Use the commands located at the bottom of the game screen in order to adjust the size of your wager. As always, a bigger bet means larger potential rewards as well! Taking a little risk might pay in Crystal Queen. Hit the Play button on the right side to set the reels into motion, or use the Autoplay mode to play without interruptions for as long as you want. That is the perfect option for you if you would rather sit back and enjoy the show for a little while! You can naturally come back to single-spin mode at any time by simply clicking the same switch once again.
Free Spins
Three or more gold symbols with a red circle scatter symbols are responsible for initiating the free spins bonus-10 free spins will be given. Keep in mind that you must activate all 56 paylines to gain the maximum from the slots-wins are paid both ways. If the 'Swooping Reels' feature is activated multiplier wins can be as high as 5x!
Spreading Wild
A spreading wild pop up on reels 1, 2 and 3 and appears during the free spins on the second, third and fourth reels. It also adds an additional 1 to 5 wilds which increases payouts.
We know the review it is not finished yet, but the game looks so cool… If you can't resist and want to play, just do it!
Overall Rating 5.0
Total Bonus
Detailed Review
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His Secret Obsession Phrases
Notwithstanding the pair came together, Éva (magnificent and winsome patricia kovács) has turn mentally addicted to 43 twelvemonth old tibor (dennis gabor máté) to such an extent that she conjures scenes with him in her flat once hes not there. Really, indian women are among a type. If you are in a family relationship wherever you are flavor your man will fall behind interest and leave you anytime. It is for every womanhood. There were a few things lacking, which mightiness make tv audience have questions: was viewing the murder of the parents essential. More geological dating services have time-tested to acquire into a recess market since rivalry has go real courageous in the last few old age. Who is his secret obsession.
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His Secret Obsession Reviews
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His Secret Obsession Amazon
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His Secret Obsession Book Review
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His Secret Obsession Pdf
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His Secret Obsession Phrases
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His Secret Obsession
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His Secret Obsession Book
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His Secret Obsession Signals
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About Anya...
my name is Anya , I'm 37 years old and mother of a 12 years old son.
I live in Köpenick, the very beautiful southeastern part of Berlin.
I've recently discovered post crossing through a friend and I think it's very exciting.
I hope to receiving picture postcards from your city.
But I like other postcards as well for example with seagulls (my very favourite animals!), the beach, the sea or something with nice quotes.
Just be free to send me postcards you have!
I'd love hand-paintings as well so I'd be happy if you draw or paint a small animal in the corner of the postcard, if you want to (don't worry, I'm not expecting artwork). Maybe you could fulfil this wish for me!
My hobbies are reading, long walks at the beach and I'm currently writing a book about seagulls.
Unfortunately my English isn't that fine, so I translate a lot with Google.
It's not the best way, but I hope you understand this.
Best greetings from Köpenick


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Sebastien Baugh
Integrated Care Fellow - Education
Seb is leading on the development of education and training resources for partners to use in the implementation of non face-to-face clinics. This includes working with a range of partners, with experience of delivering these models of care, to understand the key requirements when it comes to setting these models up. This work also includes supporting partners in setting up and evaluating non face-to-face clinics across the UCLP geography.
Seb is a Public Health Registrar on secondment with UCLP from the public health training scheme. He trained as a physiotherapist and has over 10 years' experience of working in both clinical and non-clinical settings.


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10 easy party hairstyles for women this holiday season
Mildred Europa Taylor | Editor December 30, 2019
We are still in the holiday season and most of us are waiting anxiously to usher in the new year. Every new year comes with celebrations, including parties at various party hotspots, clubs, restaurants and bars.
You probably have found an outfit, shoes, and accessories to rock any party this holiday season, but you are wondering what to do with your hair. Should you wear it long or short? Curly or straight? Buns, knots or twists?
- Five 2020 beauty resolutions you must adhere to for a flawless year
- What no one tells you about having twins
- Photos of the Nigerian queen who wowed everyone during her 1956 trip to London in traditional attire
- Get to know these five black female fashion influencers making an impact in the industry
- Check out Barbie's latest collection of diverse dolls that has got everyone talking
More about this
No matter what choice you make, these simple yet stunning hairstyles will surely make you slay any party this season:
Photos: stylisheve


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Events Calendar
September 16, 2019
PASC 2019 Education Day
|Event Starts:
|September 16, 2019
|7:00 a.m - 4:00 p.m.
|Calgary Petroleum Club (319 - 5 Avenue SW)
For full details and to register click here
October 16, 2019
PASC AGM & Luncheon: October 16, 2019
Annual General Meeting
|Event Starts:
|October 16, 2019
|11:30am - 1:00pm
|Calgary Petroleum Club (319 5th Avenue SW)
Annual General Meeting
Notice is hereby given that the Annual General Meeting of the Petroleum Accountants Society of Canada will be held:
Members are reminded that only those items on the agenda will be presented during the business portion of the meeting. There will be time on the agenda for announcements or informational items. No new business requiring decisions or motions may be added.
November 22, 2019
PASC Power Play - Carbon Tax
|Event Starts:
|November 22, 2019
|Registration and Breakfast 7:30 am Presentation 8:00 am
|Calgary Petroleum Club (319 5th Avenue SW)
Join PASC for a POWER PLAY on November 22, 2019 at the Calgary Petroleum Club as we discuss and review the implications of the Federal Fuel Charge that will come into effect in Alberta, January 1, 2020. With the repeal of the Climate Leadership Act there is no longer the 2023 oil and gas production exemption for producers. In its place, the Federal Fuel Charge will replace the Carbon Levy with new compliance requirements. The Alberta government is also currently developing an opt-in approach for Conventional oil and gas under the TIER program for emitters.
Tracey Osmond, FCPA, FCGA, Grant Thornton LLP, Calgary
Tracey is a senior manager with Grant Thornton LLP in Calgary, where she enjoys helping clients manage their Canadian sales, fuel and carbon tax risks. Her broad understanding of sales, fuel and carbon taxes is backed by 20 years of combined experience in public practice and as indirect tax director for a large fuel marketer.
Tracey has assisted hundreds of organizations with commodity tax matters such as audits, mergers and acquisitions, integrations, cross-border activities and IT implementations and uses her in-depth understanding of indirect taxes and business practices to reduce tax risks and compliance costs. She is also a past presenter on sales and carbon Tax matters.
This event qualifies for up to two hours of continuous professional development.
Members: $75.00 +GST
Nonmembers: $90.00 +GSTBreakfast will be provided
November 26, 2019
Course: Vendor Audit November 26, 2019
Vendor Audit 1/2 Day Course
|Event Starts:
|November 26, 2019
|Registration & Breakfast @ 7:30 am; Course 8:00 am to 12:00 noon
|PASC office c/o Associations Plus #600, 900 - 6 Avenue SW
Vendor Audit
In this course you will learn the following:
1. Overview of the vendor / compliance audit activity
Currently Mr. Yasin is working for Canadian Natural Resources Ltd. as a Supervisor Vendor, Audit and responsible to identify, plan, execute, facilitate and manage vendor audits in all business areas of the company. Previously, he worked for PriceWaterhouseCoopers, Ernst Young LLP, and Enbridge Gas Distribution Ltd. at different positions."
$300 +GST Members
Location: PASC Office 600, 900 6 Avenue SW, Calgary