text:
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We have products that cover census demographics dating back to 1970. Our materials provide you with comprehensive data sets, but they also allow you to create custom reports, generate thematic maps, and compare trends throughout the decades. All of these tools are easy to use, and they allow you to look at census demographics from every possible angle.
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text:
Sealing solutions
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Provide low engine emissions and adequate valve guide lubrication.

subset: commoncrawl


text:
"We initiate slow game; we had already played against them, its fast and intelligent game. We finish in sixth place that is good and congratulate Taipei plays good tournament and finish in fifth place in this World Championship. This very good experience to me and my teammates, the first round is great to us", Netherlands Captains.
"It was an interesting match for us and we are happy to finish in the fifth place. Thank to the people of Tijuana and Mexicali to the support, the experience in this city is incredible, Taiwan is hot city, but never with Mexicali" Chinese Taipei Captain. "We knew and waited for the faster style that it displayed Taipei. We could not make the adjustments. We fail our game control, the team plays good in the service and block, but the control it defined the game" Netherlands Head Coach
"Today we are happy, this victory and all World Championship is the great moment to all federation. It is the first time that we plays in this level and finish in fifth place is the great achievement to Taipei Volleyball" Chinese Taipei Head Coach


text:
Hair raising: Stop smiling and run!
Q. Oh, neat! You're outdoors on a lookout platform at Sequoia National Park when your long hair starts frizzing out like a halo, standing straight up on top. Your brother aims his camera: "Smile..." Should you? A. Steiglitz
A. Five minutes after the above woman had her photo snapped and left, a lightning strike to the platform killed one person and injured seven, say David Halliday et al. in Fundamentals of Physics. The overhead cloud system (with much visible blue sky) had created a strong electric field near the woman's head, and many of her hair strands had extended upward along the field. From her smiling, she was clearly unaware of the danger, but if this happens to you, "You had better run for shelter– not pose for a snapshot."
Q. Will AC (alternating current, e.g. wall outlets) or DC (direct current, e.g. batteries) kill you faster? D. Halliday
A. This debate raged as part of the 1880s "battle of the currents," with Thomas Edison on one side boosting his new first DC power plant, and engineer William Stanley boosting his even newer AC power plant, says James D. Livingston in Driving Force: The Natural Magic of Magnets.
AC's big advantage is its transformability into higher or lower voltages, but it also got the rap of being more dangerous. Safety critic Harold Brown did a demo where a dog survived 1,000 volts DC, but died when subjected to 300 volts AC. "But that's a small dog, not a human," AC boosters countered, so Brown answered by stepping up his demos to include more human-sized calves and even a horse.
Bring on George Westinghouse, still maintaining AC wasn't more dangerous, until Brown challenged him to a duel by electricity: "Brown would take DC through his body and Westinghouse would take AC, at gradually increasing voltages until one cried 'enough' and admitted he was wrong (or died and proved it!). Westinghouse declined the offer."
Watching all this were New York State officials, who soon introduced the first electric chair– an AC chair.
Actually, says Livingston, both types of current can be deadly depending on how the power source is constructed and how the power is delivered to the body.
Q. What's really weird about human sex? W. Masters and V. Johnson
A. Forget the fringe stuff– the "main course" itself is pretty weird. For starters, we humans don't do it like other primates, preferring to keep our lovemaking private, says University of California physiologist Jared Diamond in Why Is Sex Fun? The Evolution of Human Sexuality. That's pretty strange for a "social" species.
Moreover, the woman's infertility– whether due to being pregnant, post-menopausal or at the wrong time of the month– doesn't stop her or him. Fact is, she rarely even has a good idea if she's fertile at any particular time or not, and certainly doesn't advertise it through distinctive smells, colors, sounds as do other mammals. ("Those disgusting humans," one can imagine a dog saying, "have it any day of the month.")
Then there's her rather unique menopause: Virtually no other mammal has this, says Diamond.
And as for the male, what's the point of such an unnecessarily large organ, exceeding that of a gorilla?
Finally, why do men usually or at least often stay with the women they impregnate to help raise the children? In this, too, we among mammals are unique– and uniquely lucky, many proud Dads might add.
Q. We all know what can happen if an asteroid a mile or two wide hits the Earth (R.I.P. the dinosaurs). What if it hits the moon? N. Armstrong
A. You'd see a bright flash from a night Moon, maybe even from a daytime Moon, lasting a few minutes before cooling to invisibility, says Yale physicist Bradley E. Schaefer. The crater would be moderate-sized, maybe 100 miles across. Such hits are rarer than on Earth (bigger, stronger gravity), occurring every half billion years or so.
The crater would spew out "rays," or streaky splash- marks toward the bull's eye– seen in an amateur telescope.
But on Earth, the biggest event would come from the rocks splattered off the Moon by the impact, that then enter our atmosphere as meteors. Some small fraction would make it down to Earth as Moon rocks. About a dozen of these from past hits have been found, sent here exactly this way.
Following impact, it would take about a week for the debris to arrive, then megaspectacular is the word for the ensuing meteor show. "I went to Tunisia for the November '99 Leonids, so I know what a mere spectacular superstorm is like! This will last another week or so and the sky will be filled every second with perhaps thousands of meteors!
"Fortunately, I know of no other effects from an asteroid impact on the Moon."
Send STRANGE questions to brothers Bill and Rich at email@example.com.


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Wednesday, February 6, 2013
Chateau du Tariquet Armagnac
Word is apparently out that some crazy whiskey blogger is reviewing Armagnacs as I've started to receive unsolicited samples. As I always say, it's never too late to sell out. Today I'll be reviewing two samples I received from Chateau du Tariquet. Tariquet is a large grower/producer located in the Bas-Armagnac region. They use new, lightly toasted, fine grain barrels for the first few years of aging, presumably then transferring the spirit into used barrels. The label implies, but does not state outright, that coloring is not used (noting that the light color of the brandy is due to the lightly toasted oak barrels...and not caramel?).
Chateau du Tariquet XO, 40% abv. ($60)
The Tariquet XO is made from 60% ugni blanc and 40% baco grapes. The "100 years" statement on the bottle refers to the age of the chateau, not the age of the Armagnac in the bottle; the youngest brandy in the bottle is 15 years old.
The nose has a very light spice to it. The palate has more fruit than I've tasted in other Armagnacs along with some chocolate, then the spice comes in, but it's still very subtle. The finish is fruity with a tinge of bitterness (not in a bad way). This is more similar to a Cognac than the Armagnacs I've tasted recently, having more fruit and less spice than some of the bolder Armagnacs. While it's not overly complex, it's very sippable and pleasant. At cask strength, I bet this one would be really stunning. (Tariquet does make some cask strength expressions).
Chateau du Tariquet Blanche Armagnac, 46%
Blanche Armagnac, much like white whiskey, is a recent development. The category was created in 2005 for unaged spirits (all other Armagnac is required to be aged in oak barrels for at least one year). Blanche Armagnac, literally "white Armagnac," may not be aged in oak but is required to be stored in inert containers (glass or steel, for example) for three months. The Tariquet Blanche is made from 100% folle blanche grapes (though the concept of "Blanche Armagnac" shouldn't be confused with the "folle blanche" grape). I haven't seen this on the shelves yet, so I don't know what the retail price is.
If you read this blog with any regularity, you know that I'm not a fan of white whiskey, and I'm not sure that I feel any differently about unaged brandy. Smelling this, it's indistinguishable from white whiskey. Nosing blind, I would definitely have guessed that it was a white whiskey of some sort. The palate, though, gives it away as a brandy; it's sweeter than whiskey with some fruit notes beginning to develop late in the palate. The finish is my favorite part, with some very distinct raisin notes and some mulled wine on the nose. It's not at all bad for what it is; I actually like it better than most white whiskeys, but, well, that isn't saying much. It's always educational to try unaged versions of spirits, but I've never understood the urge to buy them. If you're into unaged spirits or mixology, though, this would be a good choice.
From these two samples, Chateau du Tariquet has definitely piqued my interest. I may track down some of their cask strength brandies to see how they measure up at full strength.
5 comments:
We visited them during their big harvest celebration. Even for a "larger" producer they make a ton of quality goods. The 8, 12, and 15 year olds are 100% folle blanche and at full proof. Solid values.
The party they through was quite fun as well. Nice people.
- February 6, 2013 at 9:10 PM
- Serge said...
Hi Sku, they used to make blanche way before 2005, it's just the appellation that's new (blanche-armagnac, 2005 indeed). People down there always liked to sip blanche on ice. Here's an older bottle from my stash (designed by Picasso, how cool is that?) http://www.whiskyfun.com/Blanche.png It was sold under the simple 'eau-de-vie de vin' appellation. Santé - Serge
- February 7, 2013 at 1:29 AM
- sku said...
Thanks for the info Serge. Fantastic bottle! When is it from?
- February 7, 2013 at 8:12 AM
i'm confused about the "three months in inert containers" requirement for the white armagnac.
if the container is inert, wouldn't the armagnac "straight from the tap," so to speak, taste the same as the one stored three months?
- February 7, 2013 at 4:40 PM
- sku said...
Anon, that's an excellent question. I asked a representative from the BNIA (the Armagnanc trade group) and received the following response:
Those obligatory three months of being in an inert container are essential for the resting and stabilizing of the Armagnac after the distillation and also after the reduction (which can take place whenever the producer deems right), where water is added. It will give it the chance to marry well giving a balanced taste....there can be a bit of air that gets in which will also help with the stabilizing.
- February 11, 2013 at 11:27 AM


text:
How goes it
hi there..whats new.Thought I would stop by since you never do.HAHA Enjoy your weekend and dont be a stranger
Hey..Yeah I'm getting the swing of things,Thanks to my daughter.I need to take my usb from my old notebook and download all my "stuff" off that before I can upload any pictures on my profile Will be working on that later today.Wish me luck!!
Phoenix is a stones throw. Downtown Phoenix where Chase Field is,isn't even 30min from my home.It was Bank One Ballpark not too long ago.The Turf for the Baseball games was called BOB Sod.It was a big deal.Everyone wanted BOB Sod in their front yards for landscape.Too Funny.
I read your story.As all our stories are,it was quite sad and I am sorry.I take it you still follow Motor Cross.Thats crazy you were here in my territory.What are the odds..right?
Have a GREAT Day.Talk to you soon.
Hi..I happened to find stumble across this site tonight and while I was wandering around I came across your photo. I am trying to get my profile up and running. It will get there. I thought I would say HI and I rolled on by.
Nice to chat with you today. Sorry I disappeared. Computer trouble. Hope to chat again.
Hi - I am a quad (c5/6) but I'm one those lucky F's that can do my own care, drive and use a manual. Yeah you should look into college and see what would be available. There was this blind woman in my technology class and she had a dude help her assignments so I don't see why someone couldn't help you while in class. You could probably do some at school and some online. I'm full time but it's spread out. I would like to teach 4th graders cuz the kids this age seem to be well-behaved but of course I'll probably get a class full of heathens lol. You can ask me any questions, if you haven't noticed I love to talk lol.
I actually know where Pahrump is, I've been there twice and you're right it's small and not much there. That's great you have good support with family and your friends. I'm not certain but I think if you were to go to college the school would get someone to help you out in class. I don't need much help at school but I still used the Disability
resource for test taking and having someone take notes for me. Well since I just started I still have 3-4years before I earn a degree, god I'll be freaking old before I get into a class lol. Thanks, I did have a great Christmas, I hope you did too.
I had to look to find this answer lol. Oh wow this happened here in NV, bummer. You seem being doing well, are you going to school? I just finished my first year in college, am going to be a school teacher. I was hurt coming home from lake mead with my then bf, we crashed his truck turning a corner. And you know the drill with all that fun shit of rehab. Yeah it's good to meet you too. I'm always around too.
good to meet you jerri
of course you can ask, the ? is will i answer, sure, i was riding my dirt bike out in pahrump nv. at a track, i crashed, we all have our stories, here's mine if you're interested http://seankelleys.com/?cat=8
how about you, how did you get so lucky to be in a chair?
Thanks for writing back. Hey, can I ask how you got hurt? You gotta laugh at shit or else it just ain't fun. Jerri
Hi - great pictures.
Send an Instant Message to s.m.kelley Using...
Junior Member
Senior Member


text:
WASHINGTON — Supreme Court justices disagreed Monday over whether states can require would-be voters to prove they are U.S. citizens before using a federal registration system designed to make signing up easier.
Arizona and other states told the justices the precaution is needed to keep illegal immigrants and other noncitizens from voting. But some justices asked whether states have the right to force people to document their citizenship when Congress ordered the states to accept and use federal "motor voter" registration cards that only ask registrants to swear on paper that they are U.S. citizens.
"I have a real big disconnect with how you can be saying you're accepting and using, when you're not registering people when they use it the way the federal law permits them to," Justice Sonia Sotomayor said to Arizona Attorney General Thomas C. Horne.
Said Horne: "It is the burden of the states to determine the eligibility of the voters."
This is the second voting eligibility issue the high court is tackling this session. Last month, several justices voiced deep skepticism about whether a section of the Voting Rights Act of 1965, a law that has helped millions of minorities exercise their right to vote, especially in areas of the Deep South, was still needed.
The court will make decisions in both later this year.
In Monday's case, the court is deciding the legality of Arizona's requirement that prospective voters document their U.S. citizenship in order to use a registration form produced under the federal "motor voter" registration law. The 9th U.S. Circuit Court of Appeals said that that 1993 National Voter Registration Act, which doesn't require such documentation, trumps Arizona's Proposition 200 passed in 2004.
Arizona appealed that decision to the Supreme Court.
Two sets of requirements
The case focuses on Arizona, which has tangled frequently with the federal government over immigration issues involving the Mexican border. But it has broader implications because four other states — Alabama, Georgia, Kansas and Tennessee — have similar requirements, and 12 other states are contemplating such legislation.
The federal "motor voter" law, enacted in 1993 to expand voter registration, requires states to offer voter registration when a resident applies for a driver's license or certain benefits. Another provision of that law — the one at issue before the court — requires states to allow would-be voters to fill out mail-in registration cards and swear they are citizens under penalty of perjury, but it doesn't require them to show proof. Under Proposition 200, Arizona officials require an Arizona driver's license issued after 1996, a U.S. birth certificate, a passport or other similar document, or the state will reject the federal registration application form.
Justice Antonin Scalia seemed to think that a sworn statement wasn't enough to allow people to register to vote. "If you're willing to violate the voting laws, I suppose you're willing to violate the perjury laws," he said.
But lawyer Patricia Millett, representing those challenging the law, answered that courts accept sworn statements as proof in criminal cases, some of which end in executions. Congress decided that a sworn statement with the risk of perjury was sufficient to register to vote in the federal system, she said. "This is not just a ticket into the state's own registration process so they can go, 'Thank you very much, (throw) it in the garbage can, now do what we would like you to do.' It is a registration form," Millett said.
The Arizona requirement applies only to people who seek to register using the federal mail-in form. The state has its own form and an online system to register to vote when renewing a driver's license. The appeals court ruling did not affect proof of citizenship requirements using the state forms.
Justice Samuel Alito asked if Arizona kept two different voter rolls, one for people who used the state system and one for those who use the federal. The answer was no.
That means that some people face one set of requirements to vote, and others a different set, he said. "This seems to me like a crazy system," Alito said.
Opponents of Arizona's law see it as an attack on vulnerable voter groups such as minorities, immigrants and the elderly. They say they've counted more than 31,000 potentially legal voters in Arizona who easily could have registered before Proposition 200 but were blocked initially by the law in the 20 months after it passed in 2004. They say about 20 percent of those thwarted were Latino.
But Arizona officials say they should be able to pass laws to stop illegal immigrants and other noncitizens from getting on their voting rolls. The Arizona voting law was part of a package that also denied some government benefits to illegal immigrants and required Arizonans to show identification before voting.
Checks since last fall by The Associated Press showed that in Colorado, election officials found 441 noncitizens on the voter rolls out of nearly 3.5 million voters. Florida officials found 207, or 0.001 percent of the state's 11.4 million registered voters. In North Carolina, 79 people admitted to election officials that they weren't citizens and were removed from the rolls, along with 331 others who didn't respond to repeated inquires.
E-ticket analogy
Horne compared the Arizona system to an airline sending out e-tickets instead of paper tickets but asking for identification before allowing passengers to board the airplane. "That would not contradict the statement that they are accepting and using e-tickets," he said.
But Justice Elena Kagan didn't accept that analogy, saying Arizona went further. "Wouldn't it contradict it if instead of saying 'Well, we'd like you to offer identification,' saying, 'Well, we'd like you also to have a paper ticket'?" she said.
Arizona asked the federal government to add the state's citizenship eligibility requirements to the federal form but was turned away. Scalia said the state should have sued to overturn that decision. "Why didn't you do that?" said Scalia, who indicated that he would look favorably on such a challenge.
The decision not to challenge was his predecessor's, Horne said.
The case is 12-71, Arizona v. Inter Tribal Council of Arizona, Inc.
Associated Press writer Jacques Billeaud contributed to this story from Phoenix.


text:
Shannon Carney necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 39 diseños de 15 diseñadores freelance.
The logo I am looking for is for a new, intense training program for Triathletes:
"TriFit - Team Squeeze"
This logo should emulate strength, endurance, and power. I am looking for this logo to go along with my company brand....Squeeze Studio Fitness. This logo can be a sub logo for the parent logo (see logo at http://www.squeezestudiofitness.com), because they both will be seen together.
Squeeze Studio Fitness is a personal training studio where we train hard! We use a lot of kettlebells, alternative methods of training, plyometrics, bands, etc. We have bootcamps, workshops and most importantly incorporate customized nutrition programs for all our clients. We have been open for a year and are growing fast. We have had offers to expand so it's now time to get a logo to brand ourselves. The TriFit Team Squeeze Logo will be worn by individuals participating in our Triathalon Training Program. This should incorporate all aspects of the triathalon: the swim, bike, and run. It should get people excited and want to be part of this. We can take someone that has never done a triathalon or someone who has done the ironman and make them stronger, faster, and more confident to bring their best performance to the table. We work hard and expect amazing results. My job and my trainers jobs are to constantly motivate and push people to the next level and build their confidence to know that they can go to the next level and that they want to.
This will be the start of additional designs that will be needed not only for this particular niche but also other niches that will be added to the company's training schedule.
- TriFit Team Squeeze font (Ameritype MD - font name) that will match up with what I have at squeezestudiofitness.com
- Please use a capital letter for "T" in Tri, "F" in Fit, "T" in Team and all capitals for "SQUEEZE" which will stay in brand with the current company logo.
- a logo that will complement with the company's current logo.
- Graphics to represent the swim, bike and run aspect of the triathalon competition.
- A logo you would be proud to display on t-shirts, tank tops, water bottles, bandanas, etc.
- There are a lot of TriFits out there so something that makes us different and more hardcore.
- Incorporating the Green, Black, and White from the company colors would be fine but not necessary. Something I could also print on black so a couple different options.
- A Team Logo look that's simple like NFL or MLB
- Please deliver the graphic in both Vector and JPeg formats.
- Something prissy, classy, or soft
- Too busy like the Minnesota Timberwolves with a lot of color
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


text:
GHC Status May 2011
GHC is still busy as ever. The GHC 7.0 branch has come and gone, and now that the branch has been closed we have finally made the long-planned switch from darcs to git. Meanwhile, we are busily working towards the 7.2 branch, and hope to make the 7.2.1 release in June. Some of the forthcoming highlights are:
In the autumn, Dimitrios and Simon PJ implemented a completely new constraint solver for the type checker; we also complete an epic JFP paper describing how it works [http://research.microsoft.com/~simonpj/papers/constraints/ OutsideIn](http://research.microsoft.com/~simonpj/papers/constraints/ OutsideIn). The new solver is far more tractable and maintainable than the old type checker, and has fixed many outstanding problems. We are still shaking out the last bugs, and we have some nifty ideas for improving performance. Based on this new foundation, we are planning to develop the type system further, notably by adding a richer kind system along the lines of Conor McBride's SHE system [http://personal.cis.strath.ac.uk/~conor/pub/she/ SHE](http://personal.cis.strath.ac.uk/~conor/pub/she/ SHE).
GHC's intermediate language (which we call "Core") is a simple, explicitly-typed lambda in the style of System F. Core is far, far simpler than Haskell (
CoreExprhas only eight data constructors), so GHC can type-check Core very fast and reliably. In theory, such a typecheck is redundant (since the original Haskell program was typechecked), but in practice, typechecking Core is a very powerful internal consistency check on GHC itself: many compiler bugs generate type-incorrect Core. This consistency check is run by
With the advent of GADTs and type families, the type system of the Core had to grow a little. For a few years we have been using an extension of System F, called System FC, as described in our 2007 paper [http://research.microsoft.com/~simonpj/papers/ext-f/ FC](http://research.microsoft.com/~simonpj/papers/ext-f/ FC). However, the way that System FC was actually implemented in GHC's Core language was a bit unsatisfactory so, with help from Brent Yorgey, Simon PJ is busy re-engineering it. In particular, FC has coercion terms, and these will now be represented by their own data type
Coercion, rather than being squeezed into
Type. Moreover, these coercion terms can get big, so there's a new "coercion optimiser" to replace big coercions by equivalent smaller ones. All this is described in our new paper NewFC. These changes will (finally) complete the type-family story by making so-called "equality superclasses" work for the first time in GHC 7.2.
José Pedro Magalhães has nearly completed his implementation of the derivable type classes mechanism described in his 2010 Haskell Symposium paper [http://www.dreixel.net/research/pdf/gdmh_nocolor.pdf Derivable](http://www.dreixel.net/research/pdf/gdmh_nocolor.pdf Derivable) and elsewhere in the HCAR link. It will be in GHC 7.2.
Edward Yang has spearheaded a flurry of work on the new code generation backend (
-fuse-new-codegen, the rewrite of the part of GHC that turns STG syntax into C--). Hoopl is now fully part of GHC [http://research.microsoft.com/~simonpj/papers/c--/ Hoopl](http://research.microsoft.com/~simonpj/papers/c--/ Hoopl), and the new path uses it extensively; we've ironed out most of the bugs in the backend; and now we're working on new optimization passes and fixing inefficiencies to get the generated code as good (or better) than the old code generator. We're still not at the point where the new code generator will generate better code, but we're pretty close! Stay tuned.
Simon Marlow and Ryan Newton have developed a neat new library for deterministic parallel progarmming in Haskell; read their ICFP submission [http://research.microsoft.com/~simonpj/papers/parallel/ DetPar](http://research.microsoft.com/~simonpj/papers/parallel/ DetPar). The model is monadic and has explicit control over granularity, but allows dynamic construction of dataflow networks that are scheduled at runtime, while remaining deterministic and pure.
Simon Marlow Has been busy implementing and benchmarking a new garbage collector. GHC's current garbage collector is of the parallel "stop-the-world" variety, where to collect the heap all cores stop running the program and collect the heap in parallel. The new collector is a "local heap" collector, in which each core has a private heap that can be collected independently of the other cores, meanwhile there is a shared global heap that is collected (much less frequently) by the usual parallel stop-the-world algorithm. We have a paper describing the new design which has been accepted at ISMM'11 (and will be online shortly). The results are mixed; while on average performance improves with the new collector for parallel programs, the improvements are not dramatic (at least up to 24 cores). The new collector is significantly more complex than GHC's current collector. Hence we do not plan to merge it into the mainline yet, but will maintain it on a git branch for the time being, while we continue to experiment with and tune it. Some improvements from the branch that were independent of the new GC algorithm have already been merged into the mainline, so 7.2.1 will see some small improvements in GC performance and stats reporting.
Simon Marlow has implemented a chunked stack representation, which should improve the performance of programs that need large stacks. See the [http://hackage.haskell.org/trac/ghc/blog/stack-chunks ChunkedStack](http://hackage.haskell.org/trac/ghc/blog/stack-chunks ChunkedStack). This is already in the mainline and will be in the 7.2.1 release.
We are fortunate to have a growing team of people willing to roll up their sleeves and help us with GHC. Amongst those who have been active recently are:
- Mark Lentczner and Dan Knapp have been working on cross-compilation support
- Continued work on the new I/O manager by Johan Tibell.
- Various improvements and build fixes for OS X, from PHO, Greg Wright, Thorkil Naur and William Knop
- Solaris fixes from Karel Gardas and Christian Maeder
- Gentoo fixes (for SE Linux and x86 FreeBSD support) from Sergei Trofimovich
- Other FreeBSD fixes from Marco Silva
- Linux PowerPC fixes from Erik de Castro Lopo
- Objective C support has been added by Austin Seipp
- Documentation updates from Orphi
- Various improvements from Michal Terepeta
- General tidyups from Matthias Kilian
- Primop improvements from Daniel Peebles
- Some GHCi improvements from Vivian McPhail and Boris Lykah
- More GHCi debugger fixes from Pepe Iborra
- LLVM development continues with David Terei
- Many people have given git help to those of us new to git
At GHC HQ we are having way too much fun; if you wait for us to do something you have to wait a long time. So don't wait; join in!
Other developments
GHC continues to act as an incubator for interesting new language developments. Here's a selection that we know about.
Jeff Epstein, in collaboration with Andrew Black, has implemented a library that brings Erlang's programming model to Haskell programmers. In particular, you can write a Haskell program that runs on a cluster of machines that do not share memory. It is all based on a modest but powerful language extension that makes it possible for a programmer to work with "static" functions; that is, ones consisting of pure code with no free variables. The paper that describes all this is called "Haskell for the cloud" [http://research.microsoft.com/~simonpj/papers/parallel/ Cloud](http://research.microsoft.com/~simonpj/papers/parallel/ Cloud).
Max Bolingbroke continues his PhD work on supercompilation, with a nice new paper [http://research.microsoft.com/~simonpj/papers/supercompilation/ ImprovingSupercompilation](http://research.microsoft.com/~simonpj/papers/supercompilation/ ImprovingSupercompilation). The plan is to make his supercompiler part of GHC, over the next year or so.
David Terei at Stanford is busy implementing Safe Haskell, a flag for GHC that will guarantee that your program has certain properties such as referential transparency and constructor access control, while still having the same semantics as it normally would. The flag basically allows you to trust the types of your program, giving you if you will a more 'pure' version of Haskell where 'unsafePerformIO' is outlawed, abstract data types are actually abstract and safety is provided by the compiler not the user. This is being done as part of a larger project by the Stanford Secure Computing Systems group involving the use of dynamic information flow based security in Haskell to build a secure web framework that allows the inclusion of third party untrusted code.
Ranjit Jhala at UC San Diego is working on implementing Liquid Types [http://goto.ucsd.edu/~rjhala/liquid Liquid](http://goto.ucsd.edu/~rjhala/liquid Liquid) within GHC. The goal is to allow programmers to use lightweight refinement types to specify key invariants which can then be verified through a combination of type inference and SMT solving.
The Parallel GHC Project
Microsoft Research is funding a 2-year project to develop the real-world use of parallel Haskell. The project is now underway with four industrial partners:
- Dragonfly (New Zealand)
- IIJ Innovation Institute Inc. (Japan)
- Los Alamos National Laboratory (USA)
- Willow Garage Inc. (USA)
with consulting and engineering support from Well-Typed. Each organisation is working on its own particular project making use of parallel Haskell. The overall goal is to demonstrate successful serious use of parallel Haskell, and along the way to apply engineering effort to any problems with the tools that the organisations might run into.
For more details, see the **link:**parallel GHC project entry, and the project home page [http://www.haskell.org/haskellwiki/Parallel_GHC_Project ParallelGhcProject](http://www.haskell.org/haskellwiki/Parallel_GHC_Project ParallelGhcProject)
Data Parallel Haskell
The main user-visible development concerning data-parallel programming with GHC since the last status report is the release of our library for regular, multi-dimensional, shape-polymorphic arrays: [http://hackage.haskell.org/package/repa Repa](http://hackage.haskell.org/package/repa Repa). The current release on Hackage performs well with GHC 7.0.3 and already includes Ben's recent work on high-performance stencil-based convolutions — see also the draft paper Stencil and Ben's screencast [ http://code.ouroborus.net/beholder/video/Edge480.mov EdgeDetect](http://code.ouroborus.net/beholder/video/Edge480.mov EdgeDetect) of a real-time edge detection application, written in Objective-C and Haskell, using the new Repa library.
We have pushed back the release of a stable version of the main DPH libraries again. They are now scheduled to be released with the forthcoming GHC 7.2.
[ChunkedStack] An overhaul of stack management, and some performance improvements, Simon Marlow, blog post, Dec2010, http://hackage.haskell.org/trac/ghc/blog/stack-chunks
[Cloud] Haskell for the cloud, Epstein, Black, Peyton Jones, submitted to ICFP 2011, http://research.microsoft.com/~simonpj/papers/parallel/
[Derivable] A generic deriving mechanism for Haskell, Magalhães, Dijkstra, Jeuring and Löh, Haskell Symposium 2010, http://www.dreixel.net/research/pdf/gdmh_nocolor.pdf.
[DetPar] A monad for deterministic parallelism, Marlow, Newton, and Peyton Jones, submitted to ICFP 2011, http://research.microsoft.com/~simonpj/papers/parallel/
[EdgeDetect] Edge-detection video, http://code.ouroborus.net/beholder/video/Edge480.mov
[FC] System F with type equality coercions, Sulzmann, Chakravarty, Peyton Jones, TLDI 2007, http://research.microsoft.com/~simonpj/papers/ext-f/
[Hoopl] A modular, reusable library for dataflow analysis and transformation, Dias, Ramsey, and Peyton Jones, Haskell Symposium 2010, http://research.microsoft.com/~simonpj/papers/c--/
[ImprovingSupercompilation] Improving supercompilation: tag-bags, rollback, speculation, normalisation, and generalisation, Bolingbroke and Peyton Jones, submitted to ICFP 2011, http://research.microsoft.com/~simonpj/papers/supercompilation/
[Liquid] Liquid types, Ranjit Jhala, http://goto.ucsd.edu/~rjhala/liquid Liquid
[NewFC] Practical aspects of evidence-based compilation in System FC, Vytiniotis and Peyton Jones, submitted to ICFP 2011, http://research.microsoft.com/~simonpj/papers/ext-f/
[OutsideIn] Modular type inference iwth local assumptions, Vytiniotis, Peyton Jones, Schrijvers, and Sulzmann, Journal of Functional Programming (to appear), http://research.microsoft.com/~simonpj/papers/constraints/
[ParallelGhcProject] The Parallel GHC Project home page, http://www.haskell.org/haskellwiki/Parallel_GHC_Project
[Repa] Regular, shape-polymorphic parallel arrays in Haskell, Keller, Chakravarty, Leshchinskiy, Peyton Jones, and Lippmeier, ICFP 2010. Paper: http://research.microsoft.com/~simonpj/papers/ndp/, Hackage package: http://hackage.haskell.org/package/repa
[SHE] The Strathclyde Haskell Enhancement, Conor McBride, 2010, http://personal.cis.strath.ac.uk/~conor/pub/she/
[Stencil] Efficient Parallel Stencil Convolution in Haskell, Lippmeier et al., http://www.cse.unsw.edu.au/~benl/papers/stencil/stencil-icfp2011-sub.pdf


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EPA and partners celebrate redevelopment at Charles George Landfill Superfund Site
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WASHINGTON -- The prevailing wisdom on Capitol Hill on Monday was that the federal government is headed toward at least a brief shutdown at midnight, given the impasse over how, if at all, President Obama's new healthcare law should figure into any stopgap spending plan.
But as House GOP leaders met, they were also considering a stopgap measure that would fund the government for another week or so as talks continue. That could push a deadline for action closer to the next budget fight, the need to raise the nation's debt limit in mid-October.
Congressional aides cautioned that the strategy remained in flux, as Speaker John A. Boehner (R-Ohio) struggled to get his troops to coalesce around their next move.
"The bigger leverage is the debt ceiling, and I think we need to shift our attention to that," said Rep. Doug Lamborn (R-Colo.), who promised to keep trying to halt the Affordable Care Act. "I don't think we should keep trying the same thing over and over again, and think only a minority think that."
PHOTOS: 2013's memorable political moments
After it was called into session Monday afternoon, the Senate quickly dismissed proposals from the House, passed early Sunday, to delay the healthcare law, commonly known as Obamacare, for a full year and to repeal the law's tax on medical devices as a condition for a stopgap spending plan.
House Republicans huddled in the Capitol basement to game out their response to the Senate action. House Majority Whip Kevin McCarthy (R-Bakersfield) said several proposals were being considered.
Possibilities include returning the spending bill to the Senate with only the medical-device-tax repeal, a one-year delay of the mandate that individuals have health insurance, or a politically thorny proposal that would eliminate subsidies the members of Congress and some staff members receive to help cover premiums for insurance in health exchanges.
Throughout the showdown, Republican strategy has been dictated by the party's most conservative flank, which has subscribed to the "Defund Obamacare" campaign championed by outside groups and Sen. Ted Cruz (R-Texas).
However, this past weekend more moderate elements in the House GOP for the first time began speaking up publicly about the political risk for the party in the event of a shutdown.
At a closed-door meeting Saturday, Rep. Charlie Dent (R-Pa.) urged his colleagues to keep in mind the "big picture," acknowledging that Obama is not likely to abandon his signature legislative accomplishment. Rep. Peter King (R-N.Y.), leaving a second strategy session Saturday, said that although he supported the party's approach at the time, a government shutdown would be "inexcusable."
What shuts down in a government shutdown
Of 233 Republicans in the House, just 17 represent districts Obama carried in the 2012 election. Nearly two dozen more are in districts that Obama only narrowly lost to Mitt Romney. That cohort would potentially suffer the most in the event of a political backlash against the party, even if the strategy was driven by those in safer, more reliably Republican seats.
Before House Republicans met Monday, members of what's known as the "Tuesday Group" of center-to-center-right Republicans got together to consider their options. Those members have wielded minimal influence in the conference this year, but could be in position to counter the more conservative forces. If a band of GOP moderates made clear they would reject all but a clean spending bill, it could force a resolution.
"The hourglass is nearly empty. The government is going to shut down," Dent said Monday. "We could launch another volley. I suspect that the Senate would then reject it and send it back. And we're going to be at the same point again. The question is at what time -- before or after the government shuts down."
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Neil Young
Guitarist / Rock Musician / Songwriter
Date Of Birth:
12 November 1945
Place Of Birth:
Toronto, Ontario, Canada
Best Known As:
Renegade rock star
One of the few Woodstock-generation rockers whose late career didn't rely on reunions and re-issues, Neil Young in the 1990s earned the title "Godfather of Grunge" -- along with a new generation of followers. From his early days with Buffalo Springfield and then Crosby, Stills and Nash & Young, and on to his 1970s heyday with his band Crazy Horse, Neil Young's plaintive voice and raw guitar earned him rock legend status with pop tunes, protest songs and even country ballads. He emerged as a solo artist in the early '70s, with the hit albums After the Gold Rush (1970) and Harvest (1972). He followed with personal projects that were less commercially successful, but by the end of the decade he and Crazy Horse proved their vitality with the hit Rust Never Sleeps (1979). After a series of minor hits and big misses in the '80s, Young returned to raw-edged rock and roll with 1990's Ragged Glory, making him a hero to fans of newer bands like Nirvana and Pearl Jam. Famously anti-war, Young spent much of the 2000s in protest mode, railing against President George W. Bush and the occupation of Iraq, and making it part of his music, as in 2006's Living With War (nominated for three Grammys, including for best rock album). His other albums include Decade (1978, a compilation of hits), Freedom (1989, with the hit "Rockin' in the Free World"), Harvest Moon (1992) and Fork in the Road (2009).
Extra Credit
Young is a model train enthusiast.
Copyright © 1998-2017 by Who2?, LLC. All rights reserved.


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Current Issue: Magnesium May Help Control Blood Pressure
A healthy diet is a cornerstone of good health. And research has found another reason why: An important mineral may help keep blood pressure at normal levels.
Back Issues
'Silent' Heart Attacks Are Common
Up to half of all heart attacks may not have the typical symptoms of crushing chest pain, shortness of breath, and cold sweats. Instead, they may be "silent," researchers say.
Caffeine and Heart Rhythm: Moderation May Be OK
Having that morning cup of coffee probably won't trigger heart rhythm problems, a new study says. That goes for tea and chocolate, as well.
Too Much Salt Still an Issue in U.S. Diets
It's better for your health if you cut back on the amount of salt in your diet. That's been the advice from health experts for a number of years, but the message apparently hasn't gotten through, the CDC says.
Keep Your Heart Healthy for Brain Health
Recent research suggests that unhealthy heart habits may affect your brain, too. This is true no matter what your age.
High Blood Pressure Still a Major Killer
In a recent study, researchers found that death rates from high blood pressure rose by 23%. But those from all other causes dropped by 21%.
Do You Need That Heart Test?
A heart attack can sometimes be the first sign that you have heart disease. That frightening fact makes early detection important. Certain tests may help to diagnose the condition. But if you are at low risk for or have no symptoms of heart disease, experts continue to advise against such screenings.
The Benefits of Mitral Valve Repair
Your heart acts as a well-oiled machine. With each beat, it pumps blood to all parts of your body. Sometimes this process isn't as efficient as it should be. That may be the case for people who have problems with their mitral valve. Surgery may fix this valve, and improve overall well-being, a recent study found.
Can Yoga Help Your Heart?
Despite its popularity, yoga is no exercise fad. The practice has been around for thousands of years. Poses like Downward-Facing Dog and Lotus speak to a balance between the body and mind. Many people who do yoga believe it promotes better health. This perk may even extend to the heart, suggests a recent review.
Americans Are Still Eating Too Many Trans Fats
A slice of apple pie, a tub of popcorn, a bag of cookies. Ever wonder what makes these tempting foods so bad for you? It may well be the trans fatty acids, or trans fats, hiding inside. These dietary fats can seriously harm your heart. The good news: Americans are eating less of them overall. But we're still eating too many, according to recent research.
Better Heart Health No Matter What Your Age
Your heart is one of the hardest working muscles in your body. It's constantly pumping blood. Heart disease can make it tough for your heart to do this job. Fortunately, research shows making healthy lifestyle changes—even later in life—may stop and actually reverse heart damage.
On a Statin? A Healthy Lifestyle Is Still Important
Statins are one of the most widely used drugs. They have helped many people lower their cholesterol. That, in turn, has lowered their risk for heart disease. Unfortunately, 2 recent studies found that some statin users may be ignoring other heart-healthy choices—namely, eating a low-fat diet and exercising regularly.


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A simple guy that enjoys the finer things in life. Things like cargo pants, manly flip flops, and sleeping without a top sheet. When not on the air, he can usually be found out in the sticks hunting whatever is in season, or shooting his mouth off on Xbox Live. Forever a fan of loud music, fat bottomed girls, and big ass guns.
Dying Little Boy's Last Wish Is for Birthday Cards
Five-year-old Danny Nickerson is a boy who was diagnosed with a rare form of brain cancer. His only wish is to get birthday cards. Let's make this happen!


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Local family's emergency trip to hospital interrupted by demonstrators
The coordinator of the protest says he gave specific instructions to participants not to break any laws and not to touch or harm anyone
HOUSTON – Hundreds of people marched in protest to the George Zimmerman verdict on Monday.
"No justice, no peace," they yelled as they walked from the Byrd Funeral Home in the 2500 block of Wheeler to the Southmore Street overpass bridge near Highway 288.
Just after 7p.m. Monday, the demonstrators spilled out onto the road and blocked traffic for about 15 minutes.
"I looked up and I see all the protesters, they're everywhere," said Georgia, who asked that her last name not be used. "So, we got into the traffic and they're stopping us and not letting us go."
Georgia was on her way to Texas Children's Hospital in the Medical Center because her 7-year-old granddaughter was having an allergic reaction to some medication.
Georgia's daughter was driving and tried to go around the demonstrators by driving on the grassy shoulder.
"One of them was hitting the windshield and I was just screaming, 'We've got to get to the hospital,' and they were screaming and chanting," she said. "All I could think of was, I got to get my granddaughter to the hospital."
"My mom rolled down the window," said Georgia's daughter. "She said, 'We're trying to get my granddaughter to the hospital,' and a guy just started hitting her."
A Local 2 camera covering the protest recorded the entire incident. On the video you could see Georgia sitting in the front seat of an SUV, she had her window down and you can see a man reach in and grab her. Georgia said she was hit.
"When we got on the road I told her, 'Let's call 911," and I could feel I had been hit," she said.
The family is upset by the whole incident and thinks the demonstrators took things too far. Georgia filed a police report and hopes that things will quiet down.
"It wasn't peaceful," she said. "It was terrifying."
Quanell X, the community activist who planned the event, told Local 2 he thought the protest was peaceful.
He also said he gave specific instructions to participants not to break any laws and not to touch or harm anyone.
The Houston Police Department did have a few officers on scene and told Local 2 it's unclear how the demonstrators were able to get onto the freeway, but the officers were working to remove them.
Copyright 2013 by Click2Houston.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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By Amy Graff
The Mommy Files
An unlikely Texas high school student is quickly gaining fame as a video of him giving a lecture to his 'lazy' teacher blazes across the Internet.
With a long mane of stringy hair and a lanky frame, Jeff Bliss has the look of a heavy metal band member—and the mind of an inspired orator.
The sophomore at Duncanville High School outside Dallas got kicked out of his World History class on Monday, but before stepping out the door, he gave the teacher a piece of his mind—and he delivers his message eloquently and intelligently, with a touch of teenage sass.
I'm telling you what you need to do. You want kids to come into your class, you want them to get excited for this? You gotta come in here, you gotta make them excited. You want a kid to change and start doing better? You gotta touch his frickin' heart. Can't expect a kid to change if all you do is just tell him. You've got to take this job serious. This is the future of this nation. And when you come in here like you did last time and make a statement about, 'Oh this is my paycheck," indeed it is. But this is my country's future, and my education.
A classmate got video footage of Bliss's tirade on his cellphone and posted it on YouTube. The original video was reportedly pulled but other clips of the footage are popping up on YouTube and bringing in hundreds of thousands of page views.
Bliss is going down as a hero. Commenters on YouTube are applauding his tongue-lashing speech. "The kid is 100% right. The teacher is uninspiring and the kid is 100 more intelligent than the teacher," JayneHefia shares.
Questing whether this video was staged? Bliss seems to be the real deal as he came forward to talk to the media. He shared with Fox News that he dropped out of high school his freshman year. When he returned as a sophomore, he decided to take school seriously and he "expects teachers to do the same."
Bliss says schools and administrators have been supportive, and while his mom is proud that her son spoke up, she thinks her son needs to work on his attitude.
Bliss also emphasized that he's not a hero. "I don't want people to look up to me as something to idolize or anything, I'm just as human as the next person," he told Fox News.
This morning the Duncanville school district released a statement in response to the video to NBC 5 Dallas:
As a district with a motto of engaging hearts and minds, we focus on building positive relationships with students and designing engaging work that is meaningful. We want our students and teachers to be engaged, but the method by which the student expressed his concern could have been handled in a more appropriate way.


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These games teach valuable skills and have a high fun and educational rating.
Your child develops logic and reasoning skills by moving their ball across an obstacle and controlling different parts of this Rube Goldberg-style contraption.
Your child develops memory skills by flipping over cards to create matches in this child-friendly version of the matching game.
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Your child develops fine motor and exploration skills by helping their stick man across an obstacle. The distance traveled is measured in yards.
Zoodles 11.8.7 Copyright (c) 2014 Inquisitive Minds, Inc. All rights reserved.


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Posts Tagged 'photo shoot'
Baby Benny & Dad June 30th, 2011
Friends of mine, a couple, were not long ago blessed with the birth of the most adorable little boy. Now, the father is an accomplished photographer himself and so it was proving a little difficult to find him in front of a lens.
So eventually they asked me to make some portraits of their little family. And it was one of the most fun shoots I'd had in a long time.
Here are a few pictures:
All shots taken with a Nikkor 50mm f/1.4 prime lens, and lit (not always directly) with two studio lights, one of which was firing through my trusty Lastolite Hi Lite background and the other through a Lastolite Ezybox softbox.
More coming soon!
Tags: baby, background, boy, ezybox, family, friends, hilite, lastolite, photo shoot, photoshoot, portrait, shoot, softbox
Posted in People, Portraits | Comments (0)


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The homes at Craig Ranch, the nationally acclaimed master-planned community in North Texas that provides beautiful green vistas and a healthy appreciation of a luxurious comfortable lifestyle. More than 400 acres of sprawling green spaces connect via running and biking trails to the five-star TPC Craig Ranch golf course, where you can head out to watch national pros tee up for the club's numerous tournaments.
Squeeze in a round of golf (or two), break a sweat at Craig Ranch Fitness Center and Spa, enjoy a tree-lined walk with friends or simply grab a quick bite at the Honleylu's Coffee. Welcome to healthy living.
Your options for a rewarding workout expand as you head down the trail to the Craig Ranch Fitness Center and Spa, where you'll find a full staff of sports pros and personal trainers to help you make the most of your exercise routine. In fact, Craig Ranch offers cutting-edge recreational amenities for just about any interest you and your children might have – The Ballfields, which attract tournament play from around the country; the McKinney Soccer Fields, which host league matches and clinics; the Metroplex's top hockey facility; and the region's best training program for high school athletes.
Craig Ranch's active Community Association plans events throughout the year for adults, children and the whole family – including the Kite Festival, holiday celebrations, and the Relay for Life to raise money for cancer research. Located in the vibrant city of McKinney – named one of the Best Places to Live in America – Craig Ranch put you minutes from dozens of corporate headquarters attracted to the area's bustling economy, and is just a short drive to DFW International Airport, shopping, dining, and arts and cultural events in Dallas.
Living at Craig Ranch offers you more than a quality home. In these neighborhoods, you'll find everything you need to enjoy your health conscious lifestyle.
Call, click or come-by the Information Center to learn more.


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Investigators to Present Preliminary Findings for Adaptimmune's Gene Engineered T Cells in MyelomaPresentation at Annual American Society of Hematology Meeting on 10 December
Oxford, UK and Philadelphia, PA) 16 November, 2012. Adaptimmune announces the publication of dual abstracts in todays issue of the Journal Blood, which report preliminary results from an early phase study using patients own T cells that have been genetically altered to attack multiple myeloma (MM) cells. Lead investigators for the study will be presenting the data on December 10th at the annual meeting of the American Society of Hematology (ASH). The trial was designed as a single arm open label extension study where patients are given standard of care (autologous stem cell transplant) in conjunction with modified T cells. The critical step in this new approach is that the infused T cells have been genetically engineered to carry receptors that help the T cells recognize and attack a tumor, while sparing healthy tissue.
Study objectives are to evaluate the safety, bioactivity and anti-tumor effect of infusion of patients own T cells that have been genetically modified to express a high affinity T cell receptor (TCR) specific for a type of tumor antigen (protein) known as a cancer testis antigen (CT antigen). The target CT antigens in the study are NY-ESO-1 and LAGE-1.
The initial six patient phase is complete and patients have reached a minimum of six month follow-up for assessment of tumor response to the treatment. Based on the encouraging preliminary results, which will be reported at the conference, the study has been extended to a target enrollment of 26 patients. To date, infusion of modified T cells have been well tolerated. The data to be reported at the ASH meeting demonstrates prolonged persistence of modified T cells, homing of the cells to marrow (the site of tumor), and suggests anti-tumor activity. Multiple myeloma is a hematologic cancer localized to the bone marrow. With standard therapy, long- term response rates are low, and the median survival for patients with this disease is three to five years. The clinical trial focuses on this unmet medical need and includes patients who have received prior treatment for their myeloma or who have disease considered to be high risk, and who are eligible for an autologous stem cell transplant (auto-SCT). Auto-SCT is the transplant of a patients own stem cells, which is a standard of care for treatment of multiple myeloma in the U.S. Infusion of the gene modified T cells occurs just following auto SCT.
Presentations at the ASH meeting will be made on Monday, December 10, in non-overlapping sessions.
Dr. Aaron Rapoport, the Chair of the clinical study, will present abstract 472 entitled Adoptive Transfer of Gene-Modified T-Cells Engineered to Express High-Affinity TCRs for Cancer Testis Antigens (CTAs) NY-ESO-1 or Lage-1, in MM Patients Post Auto-SCT. Dr. Michael Kalos, the lead correlative scientist on the study, will present abstract 755 entitled Prolonged T Cell Persistence, Homing to Marrow and Selective Targeting of Antigen Positive Tumor in Multiple Myeloma Patients Following Adoptive Transfer of T Cells Genetically Engineered to Express an Affinity-Enhanced T Cell Receptor against the Cancer Testis Antigens.
In addition, Dr. Carl June, study sponsor and recipient of the 2012 prestigious Ernest Beutler Award for major translational advances, will present data from the study at the Beutler Lecture, also on Monday.
I am very pleased to speak about this promising study at ASH this year, says Dr. June. Adaptimmunes technology is an important component of the next generation of cancer therapies predicated on harnessing the power of the T cell.
From a clinical perspective, I am encouraged by these preliminary findings which will enable us to continue to evaluate T cell therapy for myeloma, and I look forward to the opportunity to present the data for review in a national forum, says Dr. Rapoport.
Despite the preliminary nature of the study, we have learned a lot already from our careful and integrated analyses of blood, marrow and serum in these patients, says Dr. Kalos.
This allows us to correlate the engraftment, cytokine production and also changes in target tumor antigen over time, and to demonstrate anti-tumor activity of the infused cells in vivo.
We are tremendously pleased with the emerging clinical data in our myeloma programme, says Dominic Smethurst, Medical Director at Adaptimmune. We are working with a world class team of investigators, who are very engaged with ensuring the clinical advancement of this technology.
Additional study details and contact information for patients interested in finding out more about participation can be found at clincialtrials.gov, under trial identifier number NCT01352286.
Dr. Carl H. June at the University of Pennsylvania (UPenn) Abramson Cancer Center and Dr. Aaron Rapoport of the University of Maryland Marlene and Stewart Greenebaum Cancer Center, developed the study. Dr. June is the regulatory sponsor (FDA representative) for the study, Dr. Rapoport is the lead clinical investigator at the University of Maryland and protocol Chair, and Dr. Michael Kalos is the Director of the Translational and Correlative Sciences Laboratory at UPenn, and leads the correlative analyses for the study. Other investigators include Dr. Edward Stadtmauer who is the lead clinical investigator at the UPenn Abramson Cancer Center, and Dr. Dan Vogl who is a sub-investigator also at UPenn. Adaptimmune Ltd is the financial sponsor and owns the core T cell receptor technology. T cell manufacturing is performed at the Clinical Cell and Vaccine Production Facility at the University of Pennsylvania directed by Dr. Bruce Levine.
Ends Contact
Margaret HenryPR ConsultantAdaptimmune Ltd, UKT: +44 (0)1865 261491E: firstname.lastname@example.com
Images available on request: 1. T cell (blue) killing a tumor cell (red) 2. Adaptimmune laboratory Scientist cloning a T cell receptor3. Adaptimmune laboratory Scientists growing research cells4. Adaptimmune laboratory Scientists growing a cell therapy product
Notes for editorsAbout AdaptimmuneAdaptimmune is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the bodys own machinery the T lymphocyte cell to target and destroy cancerous or infected cells. Established in July 2008 with a research base in Oxford, UK and clinical base in Philadelphia, US, Adaptimmune was set up to a develop unique T cell receptor engineering technology for adoptive T cell therapy exclusively licensed from Immunocore Ltd (formerly Avidex/MediGene). Specifically, Adaptimmune makes use of the bodys ability to recognize infected or cancerous cells by enhancing the power of the T cell receptor (TCR) on killer T cells. All cells, including cancerous cells, will typically present small parts or peptides of internal proteins on their surface as part of the natural protein processing pathway. This offers a 'molecular fingerprint' of the protein called an epitope for killer T-cells from the immune system to identify and destroy. However, since cancer proteins are usually derived from self proteins against which naturally selected TCRs in the body do not respond, the Adaptimmune technology uniquely enhances the natural TCR affinity to these cancer-specific epitopes enabling targeted killing of the cancer cells.
Adaptimmune has undertaken significant preclinical development with a number of pipeline TCRs to demonstrate their potency and specificity in vitro. The TCR in the current myeloma study specifically recognizes two cancer testis antigen targets: NY-ESO-1 157-165 and LAGE-1 (HLA A2; SLLMWITQC), and was engineered using Adaptimmunes proprietary TCR engineering platform. Myeloma is the lead indication for the therapy, with related trials in melanoma and sarcoma also recruiting patients and further trials in ovarian and hepatic cancer scheduled to open in 2013. http://www.adaptimmune.com
Publisher Contact Information:Adaptimmune Ltd+44 (0)1865 firstname.lastname@example.com profile of Adaptimmune Ltd Past press releases of Adaptimmune Ltd .
Company profile of Adaptimmune Ltd Past press releases of Adaptimmune Ltd .


text:
- Format:Paperback
- Subject(s):Computing
- Author(s):Victoria Ellis, Sarah Lawrey
- Available from: December 2018
Help your students learn essential ICT skills, from Microsoft Office® basics to animations and websites.
Send a Query×
This series brings a fresh approach to ICT for students from 7 to 14 years old, mapped to the Cambridge ICT Starters syllabus for examination from 2019. Initial Steps takes students through working with text, images and graphs while introducing them to email, searching and programming. They'll use search engines to help them research topics, write a group story using email and begin programming using Scratch. Each activity is clearly introduced, with step-by-step guidance to help learners master new skills. Key words and visual examples support students' understanding. Download source files for activities from our website.
- Contents
Clear learning objectives at the start of every module demonstrate specific syllabus skills and whether they correspond to a Pass or Merit grade.
A 'Before you start' section links back to prerequisite knowledge, ensuring students are prepared and ready to tackle the module.
A strong emphasis on e-safety throughout the series encourages students to stay safe on the internet.
Fun activities – including creating images, exploring multimedia and programming – provide a steady step-by-step approach.
A practical activity at the end of each module provides task-based learning where students can consolidate all of their skills.
Opportunities for reflection allow students to monitor their learning and consider what and how they have learnt.
- Series introduction
- 1. Starting with text
- 2. Starting images
- 3. Starting graphs
- 4. Starting programming
- 5. Starting searches
- 6. Starting email.
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As Cyclone Ita finally runs out of steam after wreaking havoc along Queensland's coast, farmers are emerging as her biggest victim.
The preliminary damage bill has been estimated at $1 billion since category four Cyclone Ita hit the Queensland coast near Cooktown in far north Queensland on Friday.
It then hugged almost 1000 kilometres of coastline and unleashed heavy winds and dumping torrential rain as far south as Mackay.
The Bureau of Meteorology (BOM) on Monday afternoon downgraded Cyclone Ita from a category one system to a tropical low predicted to head further out to sea.
While there was no loss of life or serious injury, Cyclone Ita has flattened cane fields, ruined banana crops, cut the state's main highway and left a mammoth clean-up task in her wake.
Premier Campbell Newman said he did not want to downplay the cyclone's impact.
"I really hate the whole idea of people saying we've dodged something, because we haven't," he told reporters in Ingham, which had been completely cut-off by flooding.
"There are impacts on people's farms, on their businesses, on their homes, on livelihoods and we've all got to work together to help these people out."
Government assistance for affected farmers is likely to be announced in coming days.
Bowen farmer Carl Walker said it wasn't only the town's iconic tomato industry that was left reeling.
"We've got beans, corn, capsicums, cucumbers, melons - all those things get affected," he said.
Local Government Minister David Crisafulli said it was "gut-wrenching" to see flattened cane fields and ruined banana crops as he inspected damage along the coast.
"In this part of the world, it's the economy - the heartbeat," he said.
The damage is expected to be felt in consumers' hip pockets as demand for fruit and vegetables begins to outstrip supply and pushes up prices.
Third generation Ingham cane farmer Steve Guazzo said the storm wiped out 10 per cent of his 250 hectare farm only two months out from harvest time.
About 90 per cent of the Ingham region's income is linked to sugar cane.
"Any losses we have in the sugar industry in the Herbert has a flow-on effect throughout the community," Mr Guazzo, who is also vice-president of Canegrowers Australia, said.
Mr Newman said 50 per cent of residents already had their power restored in most affected areas, but the clean-up would continue for some time.
Residents in rural and remote areas would have to wait longer for services to be restored, he said.
At 4pm on Monday, the BOM finally renamed the storm Ex-Tropical Cyclone Ita, with tracking maps showing it moving away from the Queensland coast as a tropical low.


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John Sinclair Seeds
Marijuana Seeds from john sinclair seeds
A legend in the field of cannabis activism, John Sinclair has fought for recreational legalisation and the recognition of medical marijuana for over 40 years.
- Skunk Feminized Seeds$27.76
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- Viper Regular Seeds$40.32
- White Panther Regular Seeds$62.04
Now, in collaboration with Ceres Seeds, this hero of the counter-culture revolution has released his own hand-picked range of cannabis strains for the connoisseur. Consisting of an Indica, a Sativa, a Skunk and an Indica/Sativa cross, this range represents the full spectrum of psychoactive and medical effects of marijuana. These four F1 strains have been chosen to honour his supreme knowledge of cannabis quality and his history of political struggle in the fight for decriminalisation. As if you needed any more excuse to try these supreme pot seeds a portion of profits from this line go to the John Sinclair Foundation to carry on the good fight. Here at SeedSupreme Seed Bank we have the full John Sinclair range of cannabis strains available as both regular and feminized seeds, so join the revolution and get hold of yours today!


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Like many Baltimoreans, we were saddened by the recent announcement that Santoni's Supermarket in Highlandtown plans to close its doors at the end of the month and lay off more than 80 employees. Santoni's has been a venerable neighborhood institution since the 1930s, and over that time it has built a loyal following among customers. These are difficult times for small businesses of all kinds, and particularly for independent grocers who operate on thin margins and face increasing competition not only from traditional chains like Giant, Safeway and Harris Teeter but also from discount warehouses and stores like Walmart and Target.
However, the store's chief financial officer, Rob Santoni Jr., is trying to make the story entirely about Baltimore's bottle tax, of which he was perhaps the most outspoken opponent. He claims the tax, which was enacted in 2010 and increased from 2 cents per bottle to 5 cents this summer, is the "sole reason" for his store's demise. He says his store has lost more than $4 million in total sales since the bottle tax took effect, and that beverage sales declined by 28 percent during that period.
We're in no position to contradict his numbers, but it is important to consider the effect of the bottle tax, both on Santoni's and the city, in a broader context.
The grocery business is a high-volume, low profit margin industry in which huge chain stores are able to market their products nationally and offset losses from discounts in one part of the country with profits from another. Local food stores can't do that because they operate on even slimmer profit margins — often just one or two cents on the dollar — and they can quickly lose money by even relatively small changes in prices.
Mr. Santoni is far from the only independent grocer who has had difficulty staying afloat in the post-recession economy. Other members of the Maryland Food Dealers Council, the trade association he heads, report similar declines in customers and revenues since the bottle tax was passed.
Yet there are clearly other factors at work. Mr. Santoni concedes that he probably wouldn't be in the situation he's in if the store hadn't borrowed heavily to remodel just before the 2008 recession clobbered the economy — surely a necessary step to keep up with the competition but one whose timing turned out to be awful.
Mr. Santoni may be right that he would have been able to weather the challenges to his business if not for the bottle tax, but it's also important to consider what the city is getting as a result of the levy. The original tax was a time-limited budget-balancing measure, but when the mayor and City Council made the tax permanent and increased its rate, they did so as part of a broader effort to raise money to remodel and renovate Baltimore's aging schools and to build new ones. The tax became the foundation, both fiscally and politically, for a $1 billion-plus city/state partnership that will transform the city's school system over a matter of years, not decades. The ambitious project will make Baltimore a much more attractive place for families to live, and that, in turn, will help all manner of local businesses in the long run.
The loss of Santoni's as a beloved neighborhood fixture is certainly distressing, but in the business world even the best-laid plans occasionally go awry due to unexpected changes of circumstances. That appears to be what happened to Santoni's. Other city independent grocers, meanwhile, have different financial structures and business models that apparently are allowing them to soldier on despite the tax.
That gives us reason to hope that the end of Santoni's Supermarket, however lamentable, represents an isolated case rather than a trend of store closing across the city. (Even Mr. Santoni says he expects his location will be picked up by another food retailer, and meanwhile, a new Harris Teeter supermarket is due to open in the Canton Crossing development, 1.4 miles from Santoni's.) It's easy for skeptics to say that no matter what Baltimore does it will never regain the population or wealth it once enjoyed, and that the bottle tax is merely hastening its demise. Yet the city has no choice but to try, and rebuilding its crumbling school infrastructure for a new generation of students is as good a place as any to start. It took courage for city officials to embark on this path when they passed the original bottle tax, and now they must stick to it until the goal is reached.


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Dip Bread, a traditional appetizer
Friday, February 08th, 2008 9:18am
Dip bread in extra virgin Olive Oil, fresh ground herbs and spices, or Modena balsamico, is an old country tradition and culinary art. Bread dipping has its origin from Europe, primarily the Mediterranean region. Italy and Greece have made it very popular because it is a simple, yet flavorful gourmet taste experience.
When hosting a family get-together, what is more boring than crackers and cheese for party appetizers? Sliced celery sticks and cubed cheese is not the most popular appetizer either. Consider fresh sliced, toasted, Italian bread with amazing, robust, bread dipping herbs and spices as an appetizer.
Turn the purchase of a fresh baked baguette loaf of bread into gourmet hors dourves. Begin with a special blend of Italian spices, then dress with gourmet extra virgin olive oil, and you have a savory appetizer that will be raved about by your guests.
A good bread dipping seasoning is extremely versatile. It can be used to garnish salads and pasta dressings, or sprinkle over steamed vegetables, roasts and chicken while cooking. The rich Italian flavors also make an outstanding addition to any marinade for beef and poultry.
Bread dipping can be made from scratch using flavored oils, added herbs and spices and quality olive oil and balsamic vinegar. One key to a good bread dipping recipe is re-hydrating the spice mixture. This is done by adding enough water to barely cover the spices in a shallow dish and allowing to stand for at least 15 minutes. Drain excess water off and add olive oil. The re-hydration will bring out the flavors of the spices as if they were freshly diced on your cutting board. Depending on your taste other condiments such as lemon juice, cracked pepper, grated parmesan can be added for additional flavor.
A bread dip appetizer will be as good as the olive oil that you select to add to it. It is recommended to purchase a quality extra virgin olive oil with balsamic vinegar as a variation. Gourmet olive oil adds an exquisite flavor to your bread dip mixture, especially when combined with fresh baked foccacia, baguette, or sourdough bread.
Fine oil and vinegar contribute an exquisite taste to fresh sliced bread. Both can be offered on the table in the same bread dipping dish. Balsamic vinegar will pool in the olive oil adding an artistic flair to the oil and vinegar presentation especially if you use a stylish American Porcelain Bread Dipping Dish. Prepare the bread by slicing the loaf at an angle along the loaf. These slices can be halved and offered on an hors dourves platter, along side bread dipping dishes.
A bread dipping recipe is quick and easy to prepare, and for a party it saves time and energy. Bread dipping is healthy and flavorsome, a unique taste experience, and one of the finer aspects of the Old World cuisine.
[tag]dip bread, bread dip appetizer, bread dipping recipe[/tag]


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I'm just going to skip over last night's commute. You probably didn't want to read about how I used my Brompton to dispatch those ninjas anyway. Or the banal truth of what actually happened. But this morning's commute, well, that's one that I will write about and not because it features ninjas because ninjas, unfortunately, have been displaced. I blame streetcars, bike lanes, dog parks and samurai. Do samurai even fight ninjas? I feel woefully under-prepared for this whole digression and I regret bringing up fictional ninjas in the first place. Almost as much as those fictional ninjas regret trying to take me on during my ride last night only to feel the wrath of my bright blue folding bicycle. I call it Sting and it glows when ninjas are near or fictionally near, as was (wasn't?) the case last night. Anyway.
Prior to leaving home, I decided it would be prudent to apply some lube to my bike's chain, which I did and I only ended up with my hands covered in a lot of black sludge and my bike still squeaked and now I think my bike might be part bat and is using echolocation as a means to get me back and forth from work. This is a nice feature and I highly recommend it for your bicycles.
Like a lot of other cyclists, I blithely roll through red lights. The majority of times it's not especially blithe, but sometimes it's blithe and now and then I think about whether my blitheliness (not a word) is just as bad as the way drivers blithely drive over the speed limit or the way ninjas blithely attack you in the dead of night. I think when things become rote, such as a familiar commute, it's easy to accept patterns and probabilities in a way that makes you less law-abiding and less diligent. Am I hypocrite for complaining about drivers complaining about speed cameras catching them breaking the law while I jaywheel to my heart's content, rarely giving it a second thought? Yeah, probably. Does self-awareness about this hypocrisy do anything to make me ride differently? If I were to be totally honest, unlike those duplicitous ninjas, I'd say not really and only rarely do I give my attitude and behavior vis-a-vis traffic laws any kind of scrutiny. Which makes me just like most everybody else. In conclusion, I have no conclusion. Just try to be safe, I guess, and accept the consequences if you get busted when you transgress knowingly. Or never undertake any kind of self-examination about your public behavior. And brush your teeth at least twice daily. Floss cameras would be the worst!
I rode in a pack of bicyclists today down east Capitol, in position six of seven, and then in another pack of bicyclists down R Street, number five of five. It was like a spontaneously organized self-forming bike train, when commuters band together in an effort to find safety in numbers. The advantage of a real bike train, aside from the opportunity for those involved to make choo choo noises, is its constituents don't typically start racing and passing each other in an effort to prove BIKE COMMUTING DOMINANCE, which isn't in listed in the DSM, in spite of my numerous written requests. Ride as fast as you want, but don't race. Save racing for races. And save whales for whaling..wait, not that. Just save whales. You can race them, but you shouldn't. Because they're big and in the ocean. And salt water will ruin your bike. But improve your taffy. So, trade-offs.
The construction crew working on the South African embassy is exceedingly nice to people walking and riding on the sidewalk on Massachusetts Avenue. In spite of the fact that it's a crowded space and they have equipment strewn all about, the workers almost always give way and extremely cognizant of the people passing through. This isn't always the case with construction crews and I feel like it deserves a special commendation. Good job, Turner and associated subcontractors!


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7th August 2013
Costa del Sol
World Cocktail Championship, Prague 2013
We are almost ready to start World Cocktail Championship 2013 in Prague. Classic and flair bartenders will meet from 16 to 22 August at the Hilton Prague Hotel in the Czech capital. Francisco Javier Lucas, the national champion of Cocktail Championship Spain 2012 will also participate in the Contest with his cocktail 'Green Sensation'. Francisco is the bar manager at Medplaya Hotel Bali in Benalmádena Costa and a member of the Association of Spanish Barmen on the Costa del Sol (Málaga ABE). We wish him the best of luck and a very enjoyable stay! It is also now the second […]


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PALAS JEWELLERY | D Script Initial Charm
Palas Jewellery
Regular price
Size > large 26 x 26mm
Materials > sterling silver and bronze
Charms can be worn on any of our Palas chains, bracelets, bangles and leathers.
Your beautiful handcrafted Palas treasures should be handled with love at all times! The best way to keep a Palas charm sparkly and beautiful is to polish it as needed with a Palas polishing cloth!


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Sony pains pre-owned game punters with PSN Pass
Net profits
Sony has officially announced the PSN Pass, a network tollbooth for "premium" online services.
The belt will tighten in September with the launch of exclusive PS3 title Resistance 3. The game will come with a code that will allow the purchaser to play online through PSN.
Anyone purchasing secondhand copies of the game from someone who has used the code will have to buy a fresh access chit to play Resistance 3 online. Sony hasn't said how much the pass code will cost.
Whatever the price, the PSN Pass is essentially a tax on folk who buy pre-owned games.
Resistance 3 is out 9 September
A Sony spokesperson said: "We are always evaluating new programmes for our online offering, and starting with Resistance 3 this September, we will be instituting a network pass programme for PS3 games with online capabilities.
"This programme will be game-specific. Games that are a part of this programme will include a single-use registration code that grants the account holder redeeming the code full online access for that title.
"This is an important initiative as it allows us to accelerate our commitment to enhancing premium online services across our first party game portfolio."
Sony has been pondering the imposition of online fees for some time. Plus, EA, THQ, Codemasters and Warner have all used an Online Pass tool in their games. ®
Sponsored: Detecting cyber attacks as a small to medium business


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Hey Guest! If you're more than just a WildStar fan and want to keep up on the latest MMO news, reviews and opinion pieces then I'd like to suggest you visit our sister site MMO Central
Why can't Chua's be Warriors or Stalkers!
Discussion in 'WildStar Races' started by Ha'boo, Jul 19, 2013.
Page 3 of 5
Page 3 of 5


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With two locations to serve the community!
Sudharma is a Sanskrit word that means "she who follows her own path."
In a culture where 99% of families choose to birth their next generation in a medical setting, choosing homebirth is walking down an overgrown, natural, rustic path of generations past. You are boldly walking your own path and I am honored to join families on their journey.
Sudharma Birth Services seek to provide holistic, compassionate, and individual care to low risk mothers and their partners seeking to birth their babies in an out-of-hospital environment. We provide care through holistic well woman care, prenatal and birth services, educational services and by providing community education and outreach services.
We strive to make an impact on the experience of individual families birthing experience as well as the birthing culture in the United States and the larger world. We believe that peace on earth beings with birth and work tirelessly toward a future where mothers, partners, and babies find their own power during the health, natural, undisturbed birthing process.
Please visit www.SudharmaBirth.com for more information on services, resources and to contact Nicole with any questions or concerns.


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Sealing Collaboration Pays Dividends in Chamber Cleaning
The Challenge
In the very competitive environment of semiconductor chip manufacturing, reduced cost per wafer is a top priority. DuPont successfully collaborated with Spansion Inc. Fab 25 in Austin, Texas to evaluate an O-ring product designed to help increase the uptime of HDPCVD equipment operating under aggressive chamber cleaning plasma conditions.
The dramatic improvement in seal performance enabled Spansion to make a step change in their preventative maintenance (PM) schedule that resulted in increased productivity and reduced cost-of-ownership. Spansion is the largest provider of Flash memory solutions in the world for the integrated electronics market.
The Solution
For Roger Sorum, equipment engineer at Spansion Fab 25, uptime and quality are his primary responsibilities to help maintain a competitive advantage. A problem occurred in the HDPCVD equipment when process gases (SiH4, O2, He) and chamber cleaning plasma (two stage NF3 and O2 plasma) created an aggressive process environment. High particle count and leaks from seal erosion and compression set caused sealing issues in IMD and STI processes. The scheduled PM cycle was 90 days, but premature sealing issues occurred within 30–60 days with the isolation valve poppet seal, slit valve door seal and the MESC port flange insert seal. The incumbent O-ring performance issues were related to physical as well as chemical plasma attack creating seal erosion.
Replacing O-rings can take up to 12 hours to bring the machine back on line and pass wafer qualification. Some seal locations limit individual chamber production, while others limit the entire tool. "The challenge is to increase availability while reducing the total cost-of-ownership" says Sorum.
Spansion turned to DuPont for options to produce longer seal life with reduced particle generation. Within several months, DuPont developed a prototype.
After reviewing test results, parts were produced for trials against other competitive FFKM products. Kalrez® 9100 parts outperformed the competitive FFKM products under all conditions. The DuPont and Spansion team, working together, pushed Kalrez® 9100 parts to extreme parameters faster than anyone expected and contributed to the success of this process.
Key Advantages
Key learnings from the collaboration were the following:
- Active feedback during development in real time;
- Testing Kalrez® 9100 parts in the harshest possible conditions;
- Extending testing well beyond timeframes for planned maintenance to establish a new, far-reaching standard for PM limits, all with Spansion process engineering agreement. Currently, Kalrez® 9100 continues to exceed the normal Spansion PM schedule by up to 6 times longer, extending the 30-day PM out to 180 days, depending upon the seal location. Increased equipment availability has increased the fab production capacity by more than 20%, without the need to purchase and install additional equipment. Spansion has now expanded their adoption of Kalrez® 9100 to other tools in both thin films and dry etch with consistently favorable results.


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Hi everyone,
I own a silver Dvorak TouchStream that no longer works. The USB cable had gotten tangled in my chair one day, and when I stood up, the keyboard crashed to the ground. I picked it up and, much to my dismay, it stopped working.
I replaced the connecting Parlex ribbon, but it did not help.
Two interesting things to note:
1. The computer does not recognize that any device has been plugged in when I plug in the keyboard. In other words, no information is being exchanged between the keyboard and the computer.
2. The keyboard will get very hot to touch on the right half (where the USB cable connects) in a matter of minutes.
Does anyone have any suggestions or advice?
I have poured through the forum, and my next step will be to try to replace the USB cable. Has anyone successfully done this?
P.S. Love the forum! Great job Torben!


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Testing & Certification
AI to solve the world's grand challenges
$5 Million
Prize Purse
The $5 million IBM Watson AI XPRIZE is a global competition challenging teams to develop and demonstrate how humans can collaborate with powerful AI technologies to tackle the world's grand challenges.
AI for
The IBM Watson AI XPRIZE aims to accelerate adoption of artificial intelligence (AI) technologies and spark creative, innovative, and audacious demonstrations of the technology that are truly scalable to solve societal grand challenges.
The UN and its agencies are collaborating with XPRIZE to further use the IBM Watson AI XPRIZE as a repository of cases to advance the sustainable development goals that will touch more than 3 billion people on the planet.
Amir Banifatemi
General Manager of Innovation and Growth
How to Win
Team Recognition


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Search Our Huge Selection of Chevy Vehicles near Lander Wyoming!
We have a wide selection of cars at our Casper Chevrolet Dealership. Feel free to scroll through our car inventory, use the side features to narrow your search & the forms below to get in touch with us. If you don't see what you're looking for, give us a call and we'll find it for you! We look forward to hearing from you.