text:
a citibank e-mail wishes to inform you that there is a potential problem with your online checking account. you are advised to go to the citibank website using the provided link and enter your social security number in order to verify your identity. this will resolve any possible problems with your account and allow citibank to serve you better.
it will also get you robbed blind.
citibank is alerting customers across the nation about the above e-mail scam, urging customers to disregard it completely. such e-mail scams, dubbed "phishing" for how scammers "fish" for information by posing as legitimate businesses, are responsible for millions of dollars of theft and abuse every year. "although the e-mail appears to come from citibank regarding 'your checking account at citibank,' it does not, and citibank is in no way involved in the distribution of this e-mail," a citibank representative stated.
the e-mail in question bears a falsified reply-to address from a "mail.com" account. the actual text of the e-mail, complete with grammatical errors, says:
dear citibank customer, we are letting you know, that you, as a citibank checking account holder, must become acquainted with our new terms & conditions and agree to it. please, carefully read all the parts of our new terms & conditions and post your consent. otherwise, we will have to suspend your citibank checking account."
don't get taken by this scam, and you can thank idg news service for the heads-up.
eric's opinion
i don't know which is worse: the fact that scams like this happen or that people fall for them. barnum had it right indeed. when only common sense is required to avoid problems like this, you get to see just how uncommon such sense really is.
the general ignorance of your average consumer is key to understanding why identity theft is the fastest growing crime in america. while such scams have been going on for centuries, the internet allows scam artists to reach millions of people at practically no cost, all the while giving them virtual anonymity by using offshore mail servers and numbered bank accounts. this adds to the overall impression by uneducated 'net users that the internet is an unsafe place.
those of us who understand how things work realize that the 'net doesn't have to be an unsafe place, but we are in the minority. as long as this mindset endures, the potential for online commerce will be stifled.
user comments 22 comment(s)
|scam away you fools! (7:17am est thu aug 21 2003)
i'm going to be rich. the son of the former king of nigeria thinks i'm special. i'm getting my share of $26,000,000,000 just for helping him with a little project. the son of the former king of nigeria trusts me implicitly. he trusts nobody else!!!
take that geek.com!!!
– by no one scams me
|one born every minute (9:25am est thu aug 21 2003)
or so the saying goes. the concept is no different than all the junk snail mail that says you could win big money and so on. here it is just more fiendish, since lots of people become stupid as soon as they look at a computer monitor.
i think that there could be a math formula for this, this would apply to all non-computer savy people (aka geeks)
maybe that could actually apply for all people, since i do know that the more tired i am the less sense i have – by tom
|to: no one scams me. (10:03am est thu aug 21 2003)
hey wait, i thouthe he only trusted me…. – by rolling in dough
|hey look (10:08am est thu aug 21 2003)
look at all the ministries, on the tv. asking for thousands, so that some god will make your life better….you want to talk about suckers….. – by holy joe
|i see morons all around me. (10:08am est thu aug 21 2003)
"a fool and his money are soon parted."
problem with today is that there are too many fools. they need to start teaching a high school course called common sense 101, with the overwhelming growth of clueless people in america today. – by cclueless
|my brother (10:45am est thu aug 21 2003)
… almost fell for the son of a king in nigeria email scame. he seriousely asked me for my advice about it. "do you think its ligal? it's a great idea, i just dont want to get in trouble"
i guess there is a reason why they send that kind of crap out… my brother falls for it. – by maximusgeek
|common sense 101 (6:25pm est thu aug 21 2003)
good news: a new course called common sense 101 is teaching in high all over america.
bad news: fools are teaching it. – by i am busy right now
|hello the is dr professional (10:24pm est thu aug 21 2003)
– by lol
|is this a scam?? (1:46pm est mon oct 06 2003)
i got this in my email after applying for a job through the well known monster.ca…it came up as a debt collecter position available….i am going to paste it here…….you can reply at my email firstname.lastname@example.com
dear sir or madam,
information about part-time job
we are company in europe specialized in optical equipment. some of our clients established business
our business requires fast cashflow, and therefore we are seeking a representative that
you will have to receive the payment from our creditor, deposit it into your account and
we expect 3-4 payments a month to be forwarded through the representative, totaling no more
all applicants must pass a background check, must have a bank checking account in good
the representative, pursuant to the contract, will not be liable for any taxes in
our beginning wage will depend on a number of transactions that the representative will
there are no investments required from you. if in the process of work you will encounter any
if you have any questions, feel free to ask through firstname.lastname@example.com
if you do not have any other questions, and you would like to apply for this position
1. print, fill in and sign the attached contract.
|knecht & muller career opportunity… (12:50am est thu oct 09 2003)
hi. my name is crystal. two days ago i received an email just as the one above in response to an application i had submitted for the position of debt collector. my outlook would not allow me to open the attachment which was a contract i was to sign as it was "unsafe". i emailed roland mettler and asked him to fax me copy–twice. no response. i emailed the chief accountant/treasurer, carlos walser with the same request. nothing. my husband and i decided to check out the company which brought me to your site. my husband switzerland would be the place to hide money. wow!!!! am i ever glad i couldn't open that attachment. and i thank you for this site. i could have ended up in worse financial hardship than i already am…and with four kids to feed. thank you.
crystal – by crystal
|knecht & muller career opportunity (11:57am est tue oct 14 2003)
i also noticed this posting. 1st i am surprised that monster.ca did not see it as such and secondly we all should know not to send any kind of info such as sin numbers or anything with photo id's or account number as such.
i also sent e-mails asking formore info on them such as websites and have yet to get a reply – by alfie
|knecht & muller ag (9:20am est wed oct 15 2003)
they did answer my e-mail application. they even told me that a package was sent to me. i haven't received it yet, but their attachment was not unsafe to open. – by john b.
|knecht & muller (12:51am est thu oct 23 2003)
hey guys, do not and i repeat again do not sign the contract or work with these people.
yes i was fooled and i did sign the contract. i recevied a check from carlos, and it turned out to be a total fraud!…. my account is ceased for investigations. my bank knows it was not my fault and they are waiting for some more information.
however, i have to go through the hassel, and i believe they make fraud checks and use general public as middle party. if it works they get the money otherwise they could have your bank account information to take your savings!
anyways, i wrote to those guys and have not heard anything from them for past 6days….
so again my advice this entire thing is fraud.
– by saby
|this is a fraud (6:42pm est thu oct 23 2003)
they made the tv news in montreal with advice from police not to touch these guys – by mike
|knecht & muller ag (2:27pm est sat oct 25 2003)
can someone explain why it is fraud?
did the checks bounce? what happened with the signing of the contract? – by spag88
|knecht & muller ag (2:39pm est sat oct 25 2003)
how can they have your bank account information and take your money?
– by gone
|knecht & muller ag (1:09am est sun nov 23 2003)
sorry it took me so long, it is fraud because the checks they are sending to you are from fraudulent e-bay sales, thefts from banks viea trojan horses etc – by firstname.lastname@example.com
|knecht & muller (4:36pm est mon nov 24 2003)
but how do they get your bank info? – by gone
|knecht & muller ag (5:10pm est fri feb 06 2004)
my friend fell for that. here is their theory. they tell you they need help cashing checks. so your job is to recieve the checks and cash them in you account. then you take a percentage and send the rest to them. they send you the first check usually for $9500 usd. but it is a forged copy of a check from some company. say it actually clears (usually does not) and you send the money to roland or carlos. the bank will then find out that it was a fake check and your butt gets nailed for fraud. meanwhile they are off enjoying life. – by roni
|knecht & muller ag (5:14pm est fri feb 06 2004)
i wonder if you could sue monster.ca? don't they like gaurantee their job postings??
someone should check that out. – by robbie
|thanks (12:58am est sun jan 08 2006)
this is an excellent site thanks for the information! – by andy
|negotiated agreement? (9:59am est sun aug 06 2006)
request for urgent agreement
in my quest for a reliable and trusted partner for a highly important and lucrative venture cum investment, i came across your contact as a reliable partner for this venture. i am mr.tony patrick buthelezi, one of the senior accountants of absa bank of south africa. to highlight you on this proposal, there is an account opened in this bank since 1999 till 2002 after which, nobody has operated on this account again till date. after going through some old files in the records, i discovered that if i do not remit this money out urgently it would be forfeited for nothing.
the owner of this account is mr. ben andreas, a foreigner, and a miner at andreas gold co. a geologist by profession who died since 1990. no other person knows about this and my investigation further proved to me that his company does not know anything about this account and the amount involved as he made it his personal account. the money outstanding before his death was (usd16 million) sixth million united states dollars. i am now contacting you as a foreigner because this money cannot be approved to a national with a local bank account here. but can only be approved to any foreign account because the money is in us dollars and the former owner, a foreigner. i implore you to act as foreigner and beneficiary to the fund as i will then intimate you on the processes abound as well as procure all the necessary documents required to lay claim to the money.
if you are capable and willing to handle such amount in strict confidence and trust according to my instructions and advice for our mutual benefit i shall highly appreciate. i need trusted person in this business because i do not want to make mistakes i need your strong assurance and trust. with my position now in the office i can affect transfer of this money to any foreigner�s reliable account, which you can provide with assurance that this money will be intact pending my arrival in your country for disbursement. on the alternative, you can come down here to south africa fours to meet one to one after which i will effect the remittance in your presence and two of us will then proceed to your country, at least two days ahead of the money prior to it's reflect into the account as provided by you.
send me your private telephone and fax numbers upon receipt of this proposal, if you genuinely want to assist and be a co-partner. i will also want us to meet face to face, to enable us sign a binding agreement.
truly yours


text:
Hi, I'm Susan, Dani's gramma. We homeschool using the Ron Paul Curriculum because it empowers us to be authentic, to live free, and to help spread the message of liberty.
We live in the "Land of Liberty" but too many of us have never experienced the abundant life Jesus paid for us to have. Christ showed us a better way to live … a freedom lifestyle. Free from fears, doubts, and worries.
We're so used to hearing the Word but not living it. One day God said to me, "Saddle up your horses and get ready to ride – the ride of your life!" I had been living in the suburbs of Chicago for nearly two decades and had never been around horses. But His contagious enthusiasm swept me off my feet and I prayed some dangerous prayers, like, "Whatever it takes, make me like Jesus." and "Give me eyes to see as You see, ears to hear, and feet and hands that will do what You want to do."
It ruined my life, for good. It kicked me out of my Christianese comfort zone. What are the odds that a Chicago children's pastor would go live with Indians out West? Or a homeschooling mom run a hazmat site? Could a city woman become rancher?
Well, I did all those things. It's indeed been the adventure of a hundred lifetimes! I'm writing a memoir called, "On the Way Home" as part of this freedom legacy I want to leave.
The adventures are still ongoing, and in fact, another adventure beckons! I am returning to school, full circle. I am homeschooling a second generation. This time around I sought a curriculum that would prepare us for a family business.
Family is the backbone of society. My dream is to support not only my own family but to help nurture, protect, and launch other families to be self-sustaining by owning a family business.
The world system rips families apart, with parents working 2nd and 3rd jobs and children running from program to program. Everyone needs their own therapist just to survive the rate race!
I dare to believe God has a better way and that it begins with Family as our genuine home base for education, income generation, and therapy. Why not, I say?
The Ron Paul Curriculum allows us to learn all of the foundational subjects: Math, English, History, and Science but also adds Personal Finance and Business to their extensive resources. With online education it puts the heavy load on the curriculum and leaves the parents free to earn income.
So many of my peers are returning to college to advance their careers. I have thought of doing the same, but you know… not many schools today teach you how to become an entrepreneur while instilling strong family values.
This new adventure is just beginning and we invite you to share our journey. As part of our studies we are required to blog. It takes a lot of courage to hit the publish button, so your comments mean much to Dani and me!
Wish us bon voyage, if you want to… our new adventure is just beginning!
PS This is a 9th grade class and by the end of 10th grade a student is expected to launch their own business and be earning a middle-class income by age 21, with continual growth projected until they are able to retire in their mid-40's if they wish. I'm 54 years old, so that means I'd better skidaddle and get to work!

subset: commoncrawl


text:
Hello, we are Science Facultative From Tocantins, FACIT-TO, located at Araguaina City, on the north region of Tocantins. We are completing 5 years of performance offering superior education and excellence technological for ours students from all around of Brazil !!
Today FACIT-TO count with 2 Campu that welcomes all the Manager courses, Analysis and System Development and Dentistry. One of the big ones, the Campus II is build at the TO -22 margins, count with an abroad and comfortable physical structure of 150 thousand square meters with large classroom and comfortable, sector library, with about 6 thousand copies, an auditorium with capacity to 200 people, modern dental clinic, and various laboratories with last generation equipment, support rooms, conveniences rooms and a cozy restaurant. Also there is, a Management block with a new library construction.
The Campus also dispose of assecibility structures, with a tatil floor, adapters toilets, more larges door, to wheelchair access, elevator, access ramps, information boards in each door in braile and the DOSVOX system in the library to the visually impaired, for them to have access to all academic content, by the audio.
FACIT-TO have amplification plans to offer more then 10 courses, between them, they are, Medicine , Veterinary Medicine, Nursing, and Rights. Also there is a building plan to a Veterinary Hospital.
From the next page, you be introduce to know more about ours courses, activities, events and all differential that turns FACIT the Institution Bigger as your future!
Fill The Below Form and Star Searching


text:
Winter Weather Safety
With the winter weather in full force, let's review cold weather safety for your pets. Winter weather can create many hazards for your pets, such as icy sidewalks, salt exposure, and frigid cold temperatures. To keep your pets safe, remember to keep your pet on a leash when walking on icy sidewalks. This will protect your pet from slipping which can cause injuries to ligaments, bones, and muscles. Wipe your pet's feet when they come inside to remove salt from their pads, and use "pet safe" salt when possible. Lastly, bundle up your pets when the wind chill falls and keep them inside out of the elements as much as possible.
On a personal note, my dog, Millie, slipped on a patch of slush on our sidewalk a couple weeks ago. The poor girl broke her two front teeth in the fall! Luckily, she has healed nicely from her dental extractions and has made a full recovery. Accidents happen when the weather provides hazards, and I hope this advice minimizes cold weather scares for your pets!


text:
Hi! I'm trying to use OpenOffice to open a n Access database (.accdb).
I follow the instructions given in https://www.openoffice.org/FAQs/ms-acce ... ccess.html (there's a video with similar instructions on YouTube) but at step 3 ("click the 'Add' button and select the "MS Access Database line" from the drop-down list") the only entry in the dropdown list is "SQL Server".
Where am I going wrong?


text:
- 3 beds
- 2 baths
- $230,000 price
- 1602517 mls id
- Year Built: 2005
- Neighborhood: Dos Suenos Estates Correct
- Status: Active
Beautiful Southwest style home with a split floor plan and so many custom features inside and out. Vigas beams travel along the ceiling guiding you to the beautiful kiva style fireplace. Custom Portuguese tile on all the floors except bedrooms. Beautiful and functional kitchen island bar with granite counter top separates the kitchen and living area, yet is open for entertaining while preparing food. Master bedroom is spacious with egress to the spa just outside the door under a covered patio. Master bedroom en suite is large and you''ll enjoy the walk-in closet with built-in clothes chute to laundry area. Custom whole house water conditioner / filter in the large 2 car attached garage.
- Site Link
- Property SubType Single Family Detached
Courtesy of: ERA Sellers & Buyers Real Estate
Office Phone: 9155852222
Listing Agent: Muriel Sanchez
Updated: 13th February, 2017 1:51 AM.
4748 Calle De Nubes Las Cruces, NM


text:
Still doing computer stuff. Trying to get an old PC working again instead of scrapping it. Looking for a way to use an ipod with Ubuntu Linux - apparently the smart money is on Banshee.
I have scrounged an old PC from Contact - bought some replacement hard disks for it from Joe's. I like it. Have christened it "berners-lee".
Still playing Traveller. Currently running a 10-parter campaign and its quite a demanding commitment.
My life is like Java - the garbage collection is slow :) I've been tidying up the PC workshop, giving away unwanted stuff, been tidying up my house, likewise.


text:
London photo: "Blood Swept Lands and Seas of Red"
(Click here for a larger version.)
Volunteers at the Tower of London "planting" red ceramic poppies for the installation "Blood Swept Lands and Seas of Red" by artist Paul Cummins.
Today is the 100th anniversary of Britain's declaration of war on Germany, and tomorrow is the installation's official opening day, marking the first full day of the nation's involvement in World War I. Volunteers will continue adding poppies over upcoming weeks, and eventually there will be
The installation runs through November 11th. More info at the Tower of London's website, including how to buy a poppy.
I've volunteered to help plant some poppies, so perhaps I'll be able to get up close soon!
(Click here for a larger version.)


text:
- 01
- 02
- 03
- 04
- 05
Each family's needs are different and we take pride in our ability to meet those various needs in the most caring and compassionate way possible.
- Binkley's Funeral Service
Recent Obituaries
Find your loved one below to share a memory or express your condolences. You may also show sympathy by sending flowers.Send Flowers
Subscribe to Obituaries
Enter your information to receive emails when new obituaries are published.
Here For You
We make this our pledge to each and everyone we come in contact with. Whether they are family or friends, we make their association with us the most important priority we have. We are always approachable. Please accept our assistance in the sincere and simple way it is offered, with care and compassion, always.
Get in Touch
Binkley's Funeral Service (Shaunavon) LTD
206 Centre Street
Shaunavon, SK S0N 2M0
Phone: (306) 297-2412
Toll Free: 1-877-BINKLEY (246-5539)
Fax: (306) 297-2902


text:
While 20-somethings have been graduating from colleges across the U.S. this month, higher education remains a privilege that is inaccessible to many. Even though they can be prohibitively expensive, a degree offers more opportunities than ever before, including increasing your future earning... [Read More]
News & Media
Displaying 21 - 30 of 111
31 May 2017 — CNBC
15 May 2017 — Mansion Global
Sean Conlon sees increasing value in urban homes, but for him, remoteness is key Sean Conlon and his home in Malibu, California Chicago-based developer and real estate entrepreneur Sean Conlon recently wrapped up season one of the CNBC series "The Deed: Chicago." The premise: Mr. Conlon came to... [Read More]
03 May 2017 — Michigan Avenue Magazine
As the resident expert on CNBC's The Deed: Chicago, Conlon & Co. chairman Sean Conlon lends his finely-tuned real estate mind (and some much-needed funds) to struggling developers. But, as viewers of the four-episode series (which is available to watch online at CNBC.com) can glean, turning a... [Read More]
27 April 2017 — CNBC
With hard work, perseverance and luck, three men who started as janitors became self-made millionaires. Each of the men approached their success differently, but each, in his own way, did what it takes to succeed and amass wealth through savvy investing, seeking out opportunities and making every... [Read More]
Books move us. They can be modes of escapism and fantasy; they can serve as therapy or education, catharsis or self-identification. They allow us to focus – they give permission to drift. Different and differing revelations can surge and mixed emotions can flood. That's the magic of words. Here is... [Read More]
25 April 2017 — Irish Central
Sean Conlon These days, the idea has taken root the American Dream is finished, done, kaput. Just last week, The New York Times noted that a key message in The Fourth Turning, a book beloved by Trump advisor Steve Bannon, is that "the American Dream is dead." County Kildare native Sean Conlon... [Read More]
21 April 2017 — Realtor.com
Tasos Katopodis/CNBC Not everyone is cut out to flip houses, not even with the help of real estate guru Sean Conlon of "The Deed: Chicago." As proof, the fourth (and last) installment of this CNBC series, "Playing Defense on the Deed," shows Conlon striking out with his latest protégés, Kai... [Read More]
19 April 2017 — CNBC
Real estate mogul Sean Conlon went to the home improvement store with first-time flipper Kai Bandele because he invested $47,000 in a home renovation project she was leading. Conlon was nervous the home renovation was falling behind schedule and he wanted to do what he could to keep tabs on the... [Read More]
18 April 2017 — CNBC
Tony Robbins argues that hunger is the most important indicator of success. Self-made real estate tycoon Sean Conlon explains that his own hunger comes from his modest upbringing and immigrant story. Growing up, Conlon's family of seven lived in a 1,000-square-foot home in a small Irish village of... [Read More]
18 April 2017 — Huffington Post
Buying and selling property can be a lucrative way to make money...quickly. It can also be the way to lose it. Millions of viewers each week tune in to watch couples buy houses on the cheap, gut a kitchen or bathroom, slap on some paint and make tens of thousands of dollars on their investment in... [Read More]


text:
Hall Map / Categories
Hall 04
...Toshiba Machine
Navigation :
H04: Linear and Cartesian Robots
business profile
contact details
send e-mail
Loading the player ...
Offer Profile
Langhammer GmbH, is a leading supplier of transport and palletizing systems. The company specializes in production logistics. Langhammer's particular strengths lie in the modular design of their units in the areas of palletizing, pallet transport, and consumer goods handling technology. The portfolio includes individual customer-specific automation solutions for various industries. These include first and foremost the paper, tissue, and baked goods industries but also the food, chemical, and cosmetics industries.
Product Portfolio
All-in-One Palletizing & Conveying
Quality, reliability, process stability and a long life cycle –that's what palletizing robots from Langhammer stand for. A variety of infeeds and gripper systems make it possible to palletize almost any product. Due to their quick changeover times when it comes to different formats our palletizers are especially suited for handling high volumes and diverse packaging formats. Be it the stand-alone version or integrated in a palletizing center – high availability and a reliable high level of performance are the core characteristics of Langhammer machines.
Optimizing material flow results in faster cycle times, higher process exactness as well as improved working conditions, while at the same time reducing costs. Langhammer designs and builds tailor-made conveyor systems for innerplant transport tasks. Our conveyor units transport our customer's products to any given position within the plant – from processing to the warehouse, from the warehouse to shipping. Your unique and individually planned transport and conveying installation evolves from a multitude of Langhammer standard components.
more info
PDF catalog
Flexible High Performance Palletizing
Increasing productivity, optimizing processes and saving costs are factors which determine market success. An exact functioning system harmoniously integrated in a complete inner plant logistics forms the basis for optimal material flow. We are continually improving our components and adapting them to the needs of our customers to be able to constantly satisfy growing demands and requirements.
Space Saving Palletizing Solution
more info
PDF catalog
Articulated Arm Robot AR500 with TheWave
Use and Application
With this easy to program system you have the best space saving and gentle product handling solution worldwide. Discover this new combination of palletizing with either Siemens or Rockwell controls together with the spacesaving Layer Handling System TheWave.
The process involved in this new Langhammer TheWave system is simple and at the same time fascinating: carried on the gentle wave of the conveyor belt the product is taken up by the split gripper apron. Four-sided compression precisely aligns the layer formation on all sides. Resting on the gripper apron and secured by the four-sided compression plates, the layer is safely transported to the pallet and gently lowered unto it. It makes no difference if the layer pattern contains gaps or if full or half pallet layer patterns are to be transported. Conventional clamping systems exert pressure on the product layer and require interchangeable format parts for layer patterns containing gaps. TheWave does not need format parts for layers with gaps and positions the layer gently and without pressure.
The AR500 Articulated Arm Robot supports highly flexible palletizing possibilities through the use of a large variety of different grippers and operates very reliably as well as economically. Its extreme exactness makes for high quality palletizing and through the simple programmability it can be adapted to new tasks in the shortest of time.
Easy programming and maintenance via the PLC: no robot programming skills required
Optimal utilization of space and considerable space saving due to its compact design
Highly flexible palletizing solution allows for any number of layer patterns
Layer weights of up to 200 kg possible
Gentle product handling of complete layers
Consistent and proven Langhammer operating concept allows for easy configuration
Layer Palletizer PA8
more info
PDF catalog
The Allrounder in Pallet Handling
Use and Application
The Layer Palletizer PA8 is suitable for almost all consumer products in packs, cases, crates, bags, etc. The palletizer versions PA81 and PA82 are based on the PA8 base model. PA81 can carry heavy pallet loads and the pallets run through lengthwise - important when palletizing bags. PA82 is designed to handle very heavy pallet loads and pallets can run either lengthwise or crosswise. A typical application for the PA8 palletizer is found in the Hygienic Paper Industry where the standard palletizer palletizes both bundles and small packs.
Products are rotated and orientated in the infeed section as programmed in the HMI. The former pusher transfers the product in sections onto the sliding plate until a full layer has been completed. This sliding plate is located directly over the pallet bay. It opens and transfers the complete layer onto the pallet below, the pallet lift lowers the individual layers one by one, the sliding plate closes and the formation of the next layer begins. Depending on the program selected, an interleaf sheet is now placed onto the new layer. Interleaf sheets can either come off a pallet, a roll or a dispenser. Discharge of the full pallet and positioning of the next empty one is effected automatically.
High output rate with a wide product range
Precise operation allows for the direct production of sales pallets
Simple and quick product changeovers due to toolless format changes
Minimum space requirement facilitates the integration of the machine into existing production lines
Modular palletizer design adapts easily to any given layout
Extendable through the Langhammer building block system
Stack Palletizer PA14 and Stacker KST5
more info
PDF catalog
The Versatile Duo for Limited Space Situations
Use and Application
Within limited space situations the fully automatic stacking and palletizing unit is the first choice for the flexible handling of all market formats. The slimly designed Stacker KST5 proves itself to be economical and mainteance friendly when it comes to stacking plastic cases, meat crates and nestable carton trays or ones with stacking corners or mixed pallet commissioning. It can also stack cartons and trays or bakery baskets without pallets. Necessary product and format changeovers are software controlled and require no tools. The Stack Palletizer PA14 is ideally suited for palletizing pre-stacked containers and the upstream shuttle system allows for collecting different product stacks and creating mixed product pallet loads.
Each KST5 stacks the product in the form of a tower and buffers them in stack lanes which are aligned to the production lines. After four stacks or two stack pairs have been formed they are grouped into a single unit to be loaded onto pallets.The case stacks are transferred from the KST5 onto the sliding apron of the PA14. The sliding apron moves over the empty pallet and the stacks are then lowered onto it. An electrically driven side compression prevents the stacks from falling over and positions them exactly. With the use of an optional supplementary compression it is possible to palletize smaller formats such as 8 or 6 stacks.
Economic and maintenance friendly articulated arm robot alternative
Flexible plastic case and carton tray stacking heights
Changeover times for gripper and format parts are eliminated due to automatic format changeovers
Unit performance can be expanded through additional stackers
Use of Euro pallets, Duesseldorfer half pallets, and industrial pallets
Layer Palletizer PA7
more info
PDF catalog
The Consumer Goods-Specialist in Layer Handling
Use and Application
The Layer Palletizer PA7 is ideal for universal use in the middle class range and for a large variety of applications and products - such as cartons, bags, packs, containers, plastic cases etc. A typical application is its use as a line palletizer placed downstream from packaging machines, e. g. in the food industry. A variety of infeed versions and the patented integrated interleaf unit allow for a wide range of possibilities. For example, bags within a performance range of up to 1000 per hour can be palletized perfectly. The electrically driven gripper turning unit operates form-fittingly which makes for exact 90 degree right or left turns or 180 degree ones.
Products are pre-arranged in the upstream infeed and transferred in rows to the sliding plate. As soon as a complete layer has been formed the lifting platform brings the loaded plate to the stacked pallet height. The sliding plate moves the layer horizontally over the pallet, the pusher is lowered and the sliding plate moves back and this new layer is placed on the pallet stack. The lift then moves down to receive the next layer. After the last layer has been completed the pallet leaves the palletizer and a new empty pallet moves into position.
Easy operation and monitoring from floor level
Easy and quick product changes due to tool-less format changeovers
Small footprint allows for integration into existing production lines
Modular design eases adaptation to a variety of requirements
Extendable through the Langhammer building block system
Linear Robot LR03
more info
PDF catalog
Perfect Flexibility
Use and Application
The Linear Robot LR03 is a flexible palletizer and an economical solution for palletizing almost all products in the consumer goods industry and is ideally suited for palletizing bundles, boxes, bags, standard cases, bakery baskets and packs. In situations with low ceilings and limited space it is the perfect fit. The LR03 impresses with its solid construction, use of high quality components and maintenance friendly design and ensures easy operation. This robot sets standards with a load capacity of up to 500 kg and a possible palletizing height of up to 2800 mm.
The LR03 can be combined with the typical suction, clamp and fork grippers for single and multiple picks and can handle any type of interleaf sheets and empty pallets. In addition layer grippers can grasp complete pallet layers with one pick. The clear design of the color touch-panel makes for easy operation. With the optional MultiPack-Software designing new patterns is done in a matter of minutes. The open control system is based either on Siemens or Rockwell technology, whichever the customer prefers.
Economic articulated arm robot alternative
Conversion of braking energy into electrical current saves resources and the environment
Easy and cost saving installation as no support foundation is required
Easy operation due to clearly defined working area
Flexible application due to compact and modular design
Open control system allows for the installation of new pallet configurations at any time
Gantry Robots PRO03, PRO04
more info
PDF catalog
Perfect Palletizing of Consumer Goods
Use and Application
The Gantry Robots PRO03 and PRO04 can be used for palletizing almost all products such as bundles, boxes, bags, standard cases, bakery baskets and packs. Equipped with a maintenance-free axis system, strong lifting axis or telescopic lifting axis they are predestined for heavy-duty usage in the palletizing field. What characterizes our gantry robots is their high flexibility, wide operating range and precision in handling. The Langhammer gantry robot system meets the requirements needed for increasing the variety of handled products. In this way unit costs are optimized and processing safety heightened. The system's flexibility increases the machine's uptime and makes it possible to react faster to market requests. With these robots Langhammer offers a flexible, reliable and economical automatic solution.
The PRO03 moves along 3 different axes: the X-axis (lengthwise movement), the Y-axis (crosswise movement) and the Z-axis (up and down movement) which is telescopic in design. The PRO04 differs from the PRO03 primarily as regards the use of a rigid Z-axis instead of a telescoping one, this makes possible the lifting of heavier loads - up to 500 kilos.
High uptimes due to a maintenance-free guidance of the main axes
Low headroom with optional telescoping axis
Handling of very heavy loads with optional rigid Z-axis
Highly flexible due to the use of a variety of grippers
Interleaf and pallet handling possible
Articulated Arm Robots
more info
PDF catalog
Solutions for High Demands
Use and Application
Articulated Arm Robots offer highly flexible palletizing possibilities and are thus a real economical alternative. Especially profitable when with the corresponding performance two end packaging lines can be palletized by one machine. Articulated Arm Robots from Langhammer come delivered with the complete material flow environment in exact accordance with customer preferences. A turnkey installation from a single source.
The long range of the robot arm makes it possible to palletize several lines at once (up to four) with one machine. Depending on the required task 4 or 6 axis robots can be employed. Thanks to an optimized drive technology these robots belong to the fastest in their class and can handle heavy loads. Their extreme precision allows for high quality palletizing and due to their easy programmability they can be adapted to new tasks within the shortest time.
Highly flexible palletizing solutions due to quick and easy re-configurations
Extremely precise operation ensures high quality palletizing
Use of a great variety of grippers makes for high flexibility
Coordinated concept including material flow environment
Gripper Systems
more info
PDF catalog
A Large Variety
Use and Application
Grippers are usually used for palletizing with robots. Almost all possible products like cartons, boxes, baskets, trays, bags, foil packs, buckets or bottles can be handled. The right choice of the matching gripper is crucial for the palletizing result. Of most importance is the required task which determines the design of the gripper. The more complex a palletizing task is, the higher the requirements on the gripper are. For exceptional products we develop special grippers as a special solution. Contact us!
The gripper ensures that the product can be handled by the palletizing robot. Utmost priority lies in the safe and secure gripping of the product and prevention of damage to the product and the surrounding area during the palletizing procedure.
Grippers for palletizing applications can be generally classified in the following functional groups:
Clamping grippers
Fork grippers
Suction grippers
Magnetic grippers
Large assortment of gripper types for a variety of usages/applications
Clean pallet configuration through use of appropriate gripper
Format changeovers possible without changes on the gripper for the majority of grippers
Most grippers also handle interleaves and pallets thus reducing the number of machines required
Layer Handling System TheWave
more info
PDF catalog
Conveyor and Layer Gripper Combined 'Simply'
Use and Application
TheWave is a unique combination of a conveyor element with a layer gripper resulting in a machine that can take complete product layers arriving from the conveyor lane and – independent of product type and configuration – place them safely onto a pallet. TheWave can be used in all sectors of the consumer industry branch and for almost all products. Its compact design makes it possible – in contrast to the usual systems using fork or clamp grippers – to save enormously on floor space.
The principle applied in TheWave is as simple as it is fascinating: Carried on the gentle wave of the conveyor belt the product is taken up by the split gripper apron. The four-sided compression aligns the layer formation exactly on all four sides. Positioned on the gripper apron and held in place by the compression unit the product layer is transported to the waiting pallet and gently placed onto it. It makes no difference if the layer pattern contains gaps or if full or half pallets are to be transported. The standard clamp systems exert pressure on the product layer and require exchangeable format parts for layers including gaps. TheWave requires no such parts for configurations with gaps and positions the layer gently and without pressure.
Optimal use of space due to its compact design
Reduction of the footprint by more than 40% in comparison to fork gripper systems
Gentle handling of complete product layers
Handling of a variety of pallet configurations with only one gripper
Format parts are not required, thus reducing complexity and freeing warehouse space
Product and Consumer Goods Transport
more info
PDF catalog
Optimal Material Flow
Use and Application
Product transportation is an essential element of in-plant logistics. Exact and precise handling is a prerequisite for optimal material flow. Belt conveyors are ideal for transporting light to moderately heavy products. There are a variety of drive and tension units to choose from depending on the belt length and load weight. Roller conveyors can be adapted to a variety of space conditions. They are used for transporting light as well as heavy products, are impervious to dust and thus ideal for use in dusty environments.
The drives used in our conveyor technology are gear brake motors with safety clutches. The conveyors are electrically pre-installed and readied for connection to a PLC controller.
Quick throughput times, high processing exactness as well as improved working conditions through optimally planned material flow
Compatible components reduce interfaces
Large assortment of standard components:
Belt Conveyors
Curved Belt Conveyors
Small Belt Conveyors
Inclined Belt conveyors
Roller Conveyors
Wheel Conveyors
Light Roller Conveyors
Roller Conveyor Curves
Gravity Roller Conveyors
Driven Roller Conveyors
Chain Conveyors
Chain Conveyors
Traction Lifts
Vertical Lifts SPF1S, SPF1C
more info
PDF catalog
Moving Precisely Up and Down
Use and Application
Vertical lifts make material flow across several levels possible and are used wherever goods need to be transported vertically - they are ideal for the vertical transport of boxes, trays, plastic containers, bundles, pallets, and bags within automatic conveyor systems.
Vertical Lift SPF1S: Transport direction in "S" form. Outfeed side always opposite the infeed side.
Vertical Lift SPF1C: Transport direction in "C" form. Outfeed side always on the infeed side.
The vertical lift consists of a frame structure with all-round protective housing. The lift platforms are hung into circulating roller chains and during the return movement are guided vertically. The vertical conveyor runs continuously. Goods are received from a connected infeed conveyor. The drive is via a gear-brake motor with safety clutch. The vertical lift comes with complete electrical installation and is ready for connection to an external control cabinet.
Gentle transport of products and high performance due to continuous chain run
Intermediate buffering of several products possible
Up and down movement with same side or opposite side infeed/outfeed
Pallet Transport Technology
more info
PDF catalog
Components That Get Things Moving
Use and Application
Stacking or separating empty and full pallets, transporting pallets on different transport levels - these are just some of the tasks for which Langhammer offers the right solution. The wide range of roller conveyors available start with economical models without drive and continue onto driven roller conveyors with reversible transport direction and high pulling power. Driven roller conveyors, e.g. for the lengthwise transport of Euro pallets, are ideally suited for lowest building heights, such as the manual shuttle car transfer level. Transfer units and turntables make flexible pallet transport possible in the first place. They connect transport lines and change the transport direction of the pallet as required. Fully automatic pallet shuttle cars are used in modern palletizing systems and in the front zone of high-bay warehouses. In this case several material flow sources can be flexibly combined with an almost endless number of material flow targets.
The drives used in our transport technology are gear brake motors with a safety clutches. The conveyors are electrically pre-installed and readied for connecting to a PLC controller.
Complete building block system with modular standard components
Individually planned conveyor units, fine-tuned to task requirements
Large assortment of pallet transport technology:
Pallet Roller Conveyors
Pallet Chain Conveyors
Pallet Buffer Conveyors
Pallet Turntables
Pallet Transfer Units
Pallet Shuttle Cars
Empty Pallet Dispensers
Empty Pallet Testers
Pallet Lifts
Hall Map / Categories
Hall 04
...Toshiba Machine
© 1997-2018 EXPO21XX GmbH. All rights reserved
Terms and Conditions of Use of this Website


text:
Relying on coffee for a quick zip? Try this energizing snack combination instead. The slow-digesting casein protein (from cottage cheese) and complex carbs (from the crackers) will hold you over until your next meal proving a sustained release of energy.
2 hard boiled eggs, chilled for at least an hour
4 tsp salsa
2 tbsp low-fat cottage cheese
Rosemary and ground black pepper to garnish
Peel shell off eggs and cut in half. Scoop out the yolks and discard.
Arrange egg halves in a bowl and fill each with ½ tbsp cottage cheese and 1 tsp salsa.
Sprinkle with herbs and/or pepper to taste. Optional, serve with whole grain crispbread such as Ryvita.


text:
I'mve been working hard to encourage people to get out and try a microadventure. Microadventures are a refresh button for busy lives.
But I'mm very aware that the hardest thing is getting out there for the first time. So I have produced a few infographics which hopefully will serve to give people the prod necessary to take that first step. (Thank you, Andrea, for all your hard work!)
Click on the image you prefer to open a PDF file that you can then download and keep (Right Click, Save) or share the link with any friends who need a gentle kick up the backside to get out there and do stuff!
A lot of the text on the PDF infographic is clickable, leading you to relevant web entries.
Please feel free to use, distribute, print, put on your Facebook page, edit or hack as much as you wish.
If you do head off on a microadventure, please let me know. Tag it on Twitter with the hashtag #microadventure or pop something on the new Microadventures Facebook Page.
If you'd like to come on a microadventure with me sign up here.
If you have any friends who could benefit from a microadventure, please send them this link.


text:
Boyd, I. L.; Hawker, E. J.; Brandon, M. A. and Staniland, I. J.
|DOI (Digital Object Identifier) Link:
|Google Scholar:
|Look up in Google Scholar
The study aimed to test the utility of instruments deployed on marine mammals for measuring physical oceanographic variation and, using this method, to examine temperature variation in the coastal waters around South Georgia. There was a significant correlation between temperature measurements made using a towed undulating oceanographic recorder (UOR) and concurrent measurements from time-depth recorders (TDRs) fitted to lactating Antarctic fur seals foraging from the coast of South Georgia. Congruence was found at horizontal spatial scales from 0.01°×0.01° to 0.5°×0.5° (degrees of latitude and longitude), and at a vertical scale of 10 m. However, there was no significant correlation between temperature measured by TDRs in the top 5 m and sea surface temperature (SST) measured by satellite remote sensing. TDR data provided information about temperature variation vertically through the water column, and through time. The UOR data were used to recalibrate the TDR data in order to correct for the slow response time of the TDR thermistor relative to the speed of seal movements through the water column. Seasonal temperature variation was apparent, and temperatures also varied between regions, and with bathymetry. These results were consistent with the current interpretation of the coastal oceanography around South Georgia. In particular, the relationship between on- and off-shelf waters showed larger amounts of warmer surface water in a region in which more run-off was to be expected. The study also showed that Antarctic fur seals concentrate their activity in regions of colder, and presumably oceanic, water. Such instrumented animals could provide near real time data for assimilation into ocean models.
|Item Type:
|Journal Item
|oceanography; temperature measurement; frontal features; water temperature; time-depth recorders; Antarctic fur seal; Southern Ocean, South Georgia
|Academic Unit/School:
|Faculty of Science, Technology, Engineering and Mathematics (STEM) > Environment, Earth and Ecosystem Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
|Item ID:
|Depositing User:
|Mark Brandon
|Date Deposited:
|16 Apr 2008
|Last Modified:
|07 Dec 2018 09:10
|Share this page:
Altmetrics from Altmetric
Citations from Dimensions


text:
I've just started putting together a new book on the use of social media in higher education and it will be out next year. After I contributed to David Hopkin's book on Emergency Rations I felt inspired and that I could do something similar.
So back in June this year I emailed/DM'ed several people I have worked with or knew who used aspects of social media in different universities asking them if they wanted to contribute to the book. I had a great response and now the book is shaping up nicely. There are 22 chapters representing 21 different universities (plus JISC) and from a variey of different professions, lecturers, learning technologists, librarians, carrers advisors and senior managers.
Also I thought it would be a process worth blogging and tweeting about, which I will do over the the next few months.
Here are the chapter titles so far:
Professional practice.
Developing a professional online presence and effective network.
The digital, authentic you.
Putting the Digital in the Professional for Social Work Students.
Career development online – is 'The real world' losing its importance?
Exploring the tensions in personal and professional identity to enable authentic debate and dialogue.
Teaching and learning.
Exploring social media use as a distraction in the HE classroom.
Social Media and Digital Identity in Formative Assessment.
A Framework for teaching social media for staff and students in HE.
Modelled use of cloud tools and social media by academic developers.
Social Media And Its Potential Application to Creative Students.
'But I already know that': Teaching social media beyond the front page.
Digital Natives. Apocryphal abecedarians or disconnected day-dreamers?'
Leadership and Social Media: Challenge and Opportunity.
Twitter and University Leadership – Navigating PR, academic networking and social identity.
Building Networks
Building Cohort Identity through Social Media.
WeChat, WeLearn: using social media to support the experience of students on a year abroad.
Using social media to create a sense of belonging and 'connectedness' for first year undergraduate student arrivals in a School of Arts and Humanities.
Bursting out of the bubble: social media, openness and HE.
Perspectives on Networked and Open Scholarship: Affordances and Barriers.
Academics' understanding of Learning Spaces: Attitudes, practices and outcomes explored through the use of Social Media.
Learning to Twalk: an analysis of a new learning environment.
Expertise in your ears; why you should jump on the podcasting bandwagon.
The Personal Journey
A Librarian's experience of Twitter as a tool for continuous personal development.
The 'Healthy Academic', Social media and, a personal and professional journey.
Check out the hashtag too:


text:
Dagsboro, Fenwick, IR Inlet to see road construction
The Delaware Department of Transportation will take advantage of a break between winter weather and the summer season for some housekeeping. Sussex County will have several one-month road construction projects beginning in April, including at the Indian River Inlet, in Fenwick Island and west of Dagsboro.
Bridge inspection planned
DelDOT's annual bridge inspection will require daytime lane closures on Route 1 approaching both sides of Charles W. Cullen Bridge at the Indian River Inlet.
Work will run from 8 a.m. to 4 p.m. Monday through Friday, April 16 through May 9.
Inspectors from Transystems will rappel from cables to inspect the bridge.
Northbound sidewalk closures will occur intermittently from April 16 to 25. Personnel will inform pedestrians how to safely cross the work zone.
Southbound Route 1 will have right lane and shoulder closures beginning Monday, April 28. Motorists should use caution and look for bridge inspectors and traffic shifts.
No lane or shoulder closures will occur April 18 to April 20, Easter weekend.
Fenwick to see fiber optics work
Installation of a fiber optic cable in Fenwick Island will bring with it about 2 miles of intermittent lane and shoulder closures along Routes 1 and 54.
Work by Kriss Contracting will run from 9 a.m. to 3 p.m. Monday to Friday, April 4 to May 26. There will be no Friday work on April 18 or at any time after May 18.
The project will "upgrade some of the fiber optics — basically, so we at the Traffic Management Center here in Smyrna can communicate with the traffic signals," said Monroe Hite, traffic design engineer. About 2.65 miles (14,000 feet) of fiber line will replace existing conduit along the Route 1 median and north side of Route 54.
DelDOT cameras monitor traffic on Route 1 (at James Street, Dagsboro Street and Carolina Avenue) and Route 54 (at Route 1, Dukes Avenue and Lincoln Drive) and their views can be seen on DelDOT's website.
Nine Foot Road closes
West of Dagsboro, a new bridge over Whartons Branch is coming to Nine Foot Road, between Revel Road and Blueberry Lane.
Work will run from 6 a.m. Monday, April 14, until 7 a.m. Friday, May 30.
Contractor George & Lynch will remove and replace the existing metal pipe arches with a precast concrete box culvert. Additional work will include minor reconstruction of the roadway approach, installation of guardrail as needed and placement of riprap in the stream to prevent erosion.
Message signs will advise motorists of the closure and detour. The posted detour leads from Route 113 northbound onto Route 24 westbound and back to Nine Foot Road. The local detour for light trucks, cars and farm equipment is via Raspberry Road onto Blueberry Lane.
All projects are weather-dependent. For additional information, visit www.DelDOT.gov.


text:
Set Fire to the Rain
The other day I had a call from The World at One asking if I'd like to comment, from a tourism operator's perspective, on the news issued by the Met Office, that 2012 was officially the wettest year on record. I replied that here in the Lake District we are not in the least intimidated by the prospect of rain, and it's not long since that we were getting visitors from East Anglia who were coming just to be reminded what rain looked like. Rain is a part of our life here, we wouldn't have any lakes without it, and it's one of our great advantages that visitors aren't at all disappointed when it happens. I was almost tempted, but managed to restrain myself, to use that old chestnut "liquid sunshine".
But it turns out, (and why am I not surprised by this?) that the Met Office weren't being entirely honest with us. 2012 was only the wettest year in the period since 1910, which is the period during which they have digitised records. In fact (as Paul Simons of The Times tells us), they have records going back to 1766, and if you go that far back 2012 was only the third wettest. The wettest was 1872. This information sent me scurrying to my gardening magazines from that time, to see what people at the time were saying. The 'Cottage Gardener' reported that "1872 has achieved the painful notoriety of being the wettest on record". Well put, I thought. William Robinson's "The Garden" calculated that 50,000,000,000 tons of rain had fallen, and their correspondent from the Lake District, Mr Isaac Fletcher, the MP for Cockermouth, wrote that "the amount recorded on the Stye – nearly 244 inches – is marvellous, and is greatly in excess of any previous record". Robinson had published his book "The Subtropical Garden" in the previous year, which will be one reason why he is much better known now for "The Wild Garden".
The truth is that there are huge variations in rainfall across England and the average of 33 inches in 2012 says nothing about the rainfall in any particular area. Here in Grange our yearly average is 40 inches, so if we were to get only 33 it would be comparatively dry. Just a few miles away in the central lakes, they get 120 inches a year – for them 33 inches would be a drought, and in Stye it would barely wet the surface.


text:
All BrightTALK
Business Management
Human Resources
Information Technology
Research & Development
Hi [[ session.user.profile.firstName ]]
Channels I own
My feed
Watch later
My viewing history
My channels
Add profile photo
Change profile photo
Edit profile
Log out
All BrightTALK
Information Technology
Human Resources
Business Management
Research & Development
Log in
Join now
My account
Channels I own
My feed
Watch later
My viewing history
My channels
Edit profile
Log out
All BrightTALK
Information Technology
Human Resources
Business Management
Research & Development
Log in
Join now
My account
Channels I own
My feed
Watch later
My viewing history
My channels
Edit profile
Log out
Share this content
Share on LinkedIn
Share on Twitter
Share on Facebook
Upstream Viral Risk Mitigation Strategy for High Titer Biologics Manufacturing
Presented by Aaron Mack, Engineer at Biogen
This talk will focus on the risk based approach that Biogen used for determining which raw materials to initially include in its upstream raw material viral risk mitigation portfolio. High Temperature Short Time (HTST) at raw material suppliers is an integral part of this risk mitigation approach. The merits of a risk-based approach to upstream viral safety will be explored, highlighting the HTST pasteurization viral mitigation capability suppliers like Merck have introduced and expanded. Treatment parameters have been detailed in publically available peer reviewed literature and confirmed in specific raw material components prior to implementation in commercial manufacturing processes. Additionally, benefits of decoupling materials with high risk of viral contamination will be reviewed.
Followed by Implementation of a Robust Upstream Viral Mitigation Strategy for Cell Culture Feeds
Presented by David Gemmell Senior Process Engineer at Merck (Contact at firstname.lastname@example.com)
High temperature short time (HTST) pasteurization is a highly effective method to achieve virus inactivation. This technology has been typically used as an in-house pretreatment tool for high risk bioreactor feeds. The availability of HTST-pretreated feeds minimizes the need to install complex and costly systems in the bioproduction facility, which have significant capital expenditure costs and can become a process bottleneck. The availability and use of complementary virus mitigation strategies minimizes the risk of introducing adventitious agents into the bioreactor, which can impact manufacturing operations and ultimately affect drug supply to patients.
The webinar details the products and capabilities Merck have developed regarding viral removal utilizing viral filtration or viral inactivation via High Temperature Short Time pasteurization, of high-risk raw material feeds for the biopharmaceutical industries.
Oct 17 2019
83 mins
Your place is confirmed,
we'll send you email reminders
Add to calendar
Watch for free
Presented by
Aaron Mack, Engineer at Biogen & Dave Kolwyck, Director at Biogen and David Gemmell Senior Process Engineer at Merck
Watch later
Viewing Certificate
Presentation preview:
Related topics:
Risk Mitigation
Viral Filtration
High Temperature Short Time
Raw Materials
HTST Pasteurization
Channel profile
BioPharma Asia Magazine
Antisense Oligonucleotide Purification Process: Successes and Challenges During
Mar 10 2020
2:00 pm
90 mins
Robert Gronke, Ph.D., Senior Principal Scientist, Biogen and Thomas Müller-Späth, Ph.D, CTO at YMC ChromaCon
Full Title: Antisense Oligonucleotide Purification Process: Successes and Challenges During Scale-up
Presented by Robert Gronke, Ph.D., Senior Principal Scientist, Technical Development, Biogen
Recently, our first full scale GMP batch for an antisense oligonucleotide was manufactured in the newly built synthesis suite at Biogen. A four-step purification process was then carried out in the existing flexible volume manufacturing facility that, up until this point, has been used for manufacturing Biogen's protein-based parenterals. This was our first test case to demonstrate that Biogen can manufacture ASOs safely, at scale, and achieve high purity and yield. Results are presented on the scalability of the ASO process from bench to GMP scale, highlighting successes and challenges faced with scale-up of the downstream ASO process.
Followed by an industry perspective presented by Thomas Müller-Späth, Ph.D, CTO at YMC ChromaCon
Save your seat
In Situ High Speed NIR Imaging to Monitor Form Change and Drug Release from...
Mar 10 2020
10:00 am
90 mins
Patrick Wray, Senior Research Investigator, BMS and Miriam Böhmler, Senior Applications Scientist at WITec GmbH
Full Title: In Situ High Speed NIR Imaging to Monitor Form Change and Drug Release from Rapidly Disintegrating Tablets
Presented by Patrick Wray, Senior Research Investigator at Bristol-Myers Squibb
Spectroscopic imaging is a powerful chemically specific and spatially resolved approach which can be used to effectively monitor tablet dissolution. This work employs Raman mapping and Near Infrared (NIR) chemical imaging to examine drug release from model tablet formulations as complementary technologies. Modern pushbroom type NIR imaging systems allow extremely fast acquisition of chemical images. Consequently this allows us to study the chemical and physical changes which occur during drug release from rapidly disintegrating formulations.
A custom designed flow through cell is used to carry out the tablet dissolutions in such a way that the sample is presented to the optics of the chemical imaging system being used. The cell is compatible for use with NIR, Raman and Mid IR spectrometers.
Two types or formulations will be presented: Rapidly disintegrating formulations with varying amounts of super disintegrant and tablets containing a model drug exhibiting fast onset of disproportionation in pH neutral conditions.
Followed by Cutting-edge Raman Imaging for New Advances in Pharmaceutics
Presented by Dr. Miriam Böhmler, Senior Applications Scientist at WITec GmbH
Confocal Raman imaging microscopy is a non-destructive chemical characterization method based on an energy shift in excitation light scattered by molecules or crystal lattices. This is known as the Raman effect and it can be detected by a spectrometer as a Raman peak within a Raman spectrum, which can serve as a "fingerprint" for individual materials in the sample.
Save your seat
Harnessing the Power of Data Analytics to Derive Process Intelligence for Pharma
Mar 5 2020
8:00 am
90 mins
Santosh Whatkar, Senior Manager, Automation and Digital Technology at Pfizer
Full Title: Harnessing the Power of Data Analytics to Derive Process Intelligence for Pharma Manufacturing
Presented by Santosh Whatkar, Senior Manager, Automation and Digital Technology at Pfizer
At Pfizer Singapore, significance of Data Analytics was realized after a period of 1 and half years when we were able to successfully implement the pilot use cases enabling us with Digital capabilities.
It would be a sharing with the audience about the Pfizer, Singapore journey of Digital Transformation and the various learnings along the way; which enabled several attributes from teamwork, persistence, believing the vision and doing things differently. Data Analytics significance was realized after passing through this journey and we were enlightened with the amazing capabilities existing data can have. Although our problem statements existed for several years, the change in perspective of using Digital technologies and existing data enabled us to find robust solutions.
Below case studies would elaborate more on the enhancing Pfizer's manufacturing robustness leveraging on Digital Transformation capabilities –
Case Studies:
• Model based real time estimation of loss of drying
• Model based predictive ability of failure for automated valves
• Virtual sensors for energy monitoring in manufacturing environment
Case Study:
• Process condition monitoring using Machine Learning
Save your seat
Real-time Sequencing by FTIR in GMP Oligonucleotide Synthesis
Mar 4 2020
3:00 pm
90 mins
John-David McElderry, Scientist at Biogen and Dominique Hebrault, Science & Technology Business Development at Mettler-Toledo
Presented by John-David McElderry, Scientist at Biogen
Followed by an Industry Perspective presented by Dominique Hebrault, Science & Technology Business Development at Mettler-Toledo International, Inc
John-David McElderry graduated from University of Michigan with his PhD in 2012 and has been an analytical scientist and PAT expert in the Pharma/Biotech industry for seven years. He started his career at Vertex Pharmaceuticals creating PAT applications for the first continuous DP manufacturing rig and helped develop the first real-time release strategy in the industry. He is currently at Biogen where he has developed PAT-based control strategies for continuous flow chemistry of small-molecule drugs and continuous synthesis of oligonucleotide drugs. He is interested in enabling real-time control of quality attributes in pharmaceutical manufacturing through the application of smart sensors and machine learning.
Save your seat
Sampling Devices for In-line near Infrared Spectroscopy Monitoring of Powder Ble
Mar 3 2020
2:00 pm
90 mins
Anders Sparén Associate Principal Scientist at AstraZeneca and Ed Gooding, MicroNIR Photonic Applications Specialist at VIAVI
Sampling Devices for In-line near Infrared Spectroscopy Monitoring of Powder Blend Homogeneity in Continuous Manufacturing
In continuous direct compression of pharmaceutical formulations, it is essential to assess the homogeneity of powder blends. This could preferably be done in situ, using fast spectroscopic techniques. In this study, near-infrared spectroscopy was used to study powder blend homogeneity at two positions in the continuous manufacturing process; after the first blender and in the tablet press feed-frame. The focus of the study was on sample presentation at the two positions, and several sampling devices were tested in a laboratory setting using a model formulation, aiming at improving the quality of the NIR measurements. The results for the sampling devices tested are compared and the future implementation in the continuous manufacturing equipment is discussed.
Followed by Powder Blend Homogeneity Monitoring with the Viavi MicroNIR PAT-W
The MicroNIR PAT-W wireless NIR spectrometer is used in monitoring blend uniformity in pharmaceutical manufacturing. The PAT-W is a rugged, IP65/67 rated instrument with no moving parts. The PAT-W, with >8 hours battery life, WiFi communication and onboard gravity sensor is well suited for use on tumble blenders in regulated facilities. Viavi's Linear Variable Filter technology, optical fiber-free design and dual onboard tungsten lamps ensure excellent stability, long lifetime and minimal instrument-to-instrument variability. Viavi MicroNIR Pro software provides data acquisition and chemometric model building, and assures compliance with Title 21 CFR Part 11, USP chapter 1119 and EP chapter 2.2.40. OPC communication and control are also available for use in process environments.
Save your seat
High-Resolution Characterization of Structure, Interaction, and Miscibility
Feb 11 2020
60 mins
Eric Munson, Professor and Head at Purdue University
Full Title: High-Resolution Characterization of Structure, Interaction, and Miscibility of Drug Products
The local interactions between a drug and its surrounding environment is critical in both small and large molecule formulations. For small molecules, the drug-polymer interaction is needed to ensure that the drug does not crystallize in an amorphous solid dispersion. For proteins, phase separation in lyophilized formulations will lead to reduced stability and the potential for aggregation. In this presentation, the ability to probe these local structures and interactions in both small and large molecule systems will be shown. Case studies will be presented that demonstrate how structural properties (e.g. degrees of interaction, changes in conformation) can impact functional properties such as crystallization and aggregation.
Eric Munson of Purdue University
Eric Munson, Ph.D., is currently Professor and Head of the Department of Industrial and Physical Pharmacy at Purdue University. He received his B.A. degree from Augustana College in Sioux Falls, South Dakota, in 1987. After studying one year in Munich, Germany, on a Fulbright Fellowship, he received his Ph.D. in 1993 from Texas A&M University, and was a postdoctoral fellow at the University of California, Berkeley in 1994. He was in the Chemistry Department at the University of Minnesota before moving in 2001 to the Pharmaceutical Chemistry Department at the University of Kansas, to the Pharmaceutical Sciences Department at the University of Kentucky in 2010, where he was the Patrick DeLuca Endowed Professor in Pharmaceutical Technology. In 2018 he moved to Purdue University to become Professor and Head of the department. His research program is focused on the characterization of pharmaceutical solids using a variety of analytical techniques, with an emphasis on solid-state NMR spectroscopy. Dr. Munson is a coinventor on three patents and has published more than 100 research, review, and book chapters.
Watch now
Identification of Approaches to Simulated Leachable Studies: What are They? W...
Feb 3 2020
81 mins
Jason Creasey, Managing Director at Maven E&L and Karen Pieters, Ir. Team Leader E&L at Nelson Labs Europe
Full Title: Identification of Approaches to Simulated Leachable Studies: What are They? When to do Them?
Presented by Jason Creasey, Managing Director at Maven E&L Ltd. Followed by an Industry Perspective presentation presented by Karen Pieters, Ir. Team Leader Extractables and Leachables at Nelson Labs Europe
The term "Simulated leachable studies" is open to interpretation. I hope to provide a definition of this term and in doing so suggest when they can and should be used. The general aim of such studies is to provide an accurate qualitative and quantitative description of the substances which might be present as leachables in a pharmaceutical drug product (DP) derived from container closure system (and sometimes its manufacturing process) when the drug product is stored up to and including its shelf-life. Simulated studies provide an alternative to analysis of leachables directly in the drug product. A simulated study aims to avoid some of the downfalls of leachable analysis such as; inaccurate analysis of leachables due to interference from drug product and/or formulation elements, availability of stored DP samples, reaching required limits of detection in the DP and time / resource constraints associated with complex method development using DP.
Simulated leachable studies must be able to accurately simulate the expected leachables in a DP and should be carefully crafted to achieve this. The system used for extraction must have similar propensity to leach from materials under study a drug product and care must be taken not to use system which either leach too much (potentially masking other substance) or too little.
Watch now
Identification of unknown extractables and leachables using mass spectrometry...
Jan 30 2020
58 mins
Petra Booij, Investigator at GlaxoSmithKline & Dr Kyle D'Silva, Pharma & BioPharma Marketing Leader, Thermo Fisher Scientific
Full Title: Identification of unknown extractables and leachables using mass spectrometry: Identification with confidence?
Extractable and Leachable (E&L) studies on materials used in the manufacturing process and container closer systems of drug products and drug substances are commonly used to assess the risk for patient exposure. Most often LC-MS or GC-MS is used to detect, identify and then quantify extractables and leachables. In general, an analytical evaluation threshold or reporting threshold is set based on a calculated patient exposure. Substances above the set threshold required further investigation if patient exposure exceeds this. Substances can be identified using mass spectral libraries to enable a toxicological risk assessment which considers the risk of patient exposure. However, how confident are we when we identify a substance using spectral libraries? A match with mass spectral libraries, data from orthogonal techniques, fragmentation data and availability of a certified reference standard can increase the level of confirmation. We will discuss an approach for different levels of identification and how to increase the level of confidence of identified extractables and leachables
Watch now
Qualification of Raw Materials and Cell Substrates for Biomanufacturing
Jan 16 2020
84 mins
Maura Kibbey Senior Scientific Fellow, Global Biologics at USP and Martin Wisher, Global Head of Regulatory Affairs at Merck
Presented by Maura C. Kibbey, Ph.D., Senior Scientific Fellow, Global Biologics U.S. Pharmacopeia
Followed by an Industry Perspective presented by Martin Wisher, PhD, Global Head of Regulatory Affairs at Merck
The quality of starting materials is critical for successful pharmaceutical manufacturing strategies. For biomanufacturing the challenges are further amplified due to the use of a wide variety of raw materials, cell lines, and naturally-derived materials with an increased risk for the introduction of unwanted impurities and adventitious agents. This presentation will provide an overview and updates on USP documentary standards containing best practices for qualifying incoming materials, demonstrating viral clearance, cryopreservation, cell banking, and controlling impurities derived from cell substrates for therapeutic proteins.
Watch now
Monitoring Impurities in Biologics
Nov 26 2019
60 mins
Diane McCarthy, PhD, Senior Scientific Liaison, Global Biologics, US Pharmacopeia
The complexity of biotherapeutic products and their manufacturing processes can yield a variety of impurities, which must be monitored and controlled to minimize safety concerns and ensure product quality. These impurities can be broadly grouped into two categories: 1) product-related impurities, such as precursors, aggregates and degradation products, and 2) process-related impurities, such as host cell DNA, host cell protein, and particulates. This presentation will provide an overview of approaches for monitoring impurities, including a discussion of existing USP standards and standards under development to support impurity testing.
Presented by Diane McCarthy, PhD, Senior Scientific Liaison, Global Biologics, US Pharmacopeia
Dr. McCarthy is a Senior Manager, Science and Standards within USP's Global Biologics Department. Diane works with stakeholders to identify areas where standards are needed and define and develop new standards. Prior to joining USP, Dr. McCarthy was Senior Scientific Director at Caprion Biosciences, where she focused on the use of mass spectrometry for characterization of biologics and host cell proteins. Her previous roles also included Director of Scientific Affairs at Ezose Sciences, where she focused on identification and quantitation of glycans by mass spectrometry and Global Manager, Biomarker Research Center, at Bio-Rad Laboratories, where she directed translational and biomarker research contracts and collaborations with industry, key consortia, academic, and government groups.
Watch now
Biopharmaceutical process development – Trends/ Challenges/Opportunities
Nov 20 2019
64 mins
Kumar Gaurav, AGM (Regulatory Affairs) at Panacea Biotec Ltd and Sudhakar Nagaraj, Principal Scientist, SLS at Pall Biotech
Presented by Kumar Gaurav, AGM (Regulatory Affairs) at Panacea Biotec Ltd
Current trends and regulation affecting Biopharmaceutical Industry
Journey from Lab scale to Commercial –Overcoming Scalability design hurdles
QbD-Bringing Improvements in Biologics development and Manufacturing Space
Followed by Quality by Design (QbD) Approach for a Virus Filtration Application
Presented by Sudhakar Nagaraj, Principal Scientist, SLS – Global Regulatory and Validation Consulting group at Pall Biotech
Removal of viruses in bioprocessing applications is a fundamental regulatory requirement, and the use of virus filtration is considered a robust and well accepted component of a virus clearance strategy. With the advent of the International Conference of Harmonization (ICH) Q8 Pharmaceutical Development and Q9 Quality Risk Management guidelines, there is much greater emphasis for filter users to define the filter design space, in addition to performing the mandatory virus filtration validation studies.
A thorough understanding of the virus filtration design space not only alleviates the risk of viral contamination, but an in-depth understanding of the boundaries of the process parameters ensures the manufacturing process remains in control. In this webinar, we describe an approach to implement QbD principles into virus filtration to create a safe and robust biomanufacturing process.
Watch now
Biopharmaceutical Process Model Evolution – Enabling Process Knowledge Continuum
Nov 15 2019
67 mins
Saly Romero-Torres, PhD, of Biogen and David Lovett & John Mack of Perceptive Engineering
Full Title: Biopharmaceutical Process Model Evolution – Enabling Process Knowledge Continuum from an Advanced Process Control Perspective
Presented by Saly Romero-Torres, PhD, Senior Manager, Advanced Data Analytics, Biogen
Biogen is adopting modeling maturity models similar to the ones used by high tech industries such as semiconductors, electronics and AI. The focus of this maturity model is to ensure that a plan for model evolution is conceived, and socialized, among SMEs and regulatory agencies early on during process development. This plan is crucial particularly when implementing data driven models that rely on process experience. A well-planned modeling continuum should allow the pharmaceutical industry to realize the benefits from modeling activities early on, while evolving into more mature prescriptive controllers that operate within Established Conditions (EC) and are potentially implemented through Post-Approval Change Management Protocols (PACMPs).
Followed a Presentation by David Lovett, Managing Director & John Mack, Engineering Director at Perceptive Engineering
Watch now
Just in Time Release of CAR T Cell Therapies
Nov 11 2019
77 mins
Irving Ford, Head of CAR T QC Laboratories at Celgene and Lori Daane, Pharma Microbiology Scientific Director at bioMérieux
Presented by Irving Ford, Head of CAR T QC Laboratories at Celgene
The views and opinions expressed during the Webinar are those of the presenter.
Currently CAR T products typically represent the final treatment option for patients suffering from various forms of cancer. It is critical that CAR T products are manufactured and returned to the patient in an expedited manner. As such manufacturers of CAR T products must adopt and utilize Quality Risk Management (QRM) principles during manufacture, testing, and release.
Risk based contamination control strategies must be employed from apheresis collection through final product release. A risk assessment, encompassing each step of the manufacturing process, should be performed to highlight potential areas of microbial ingress. Where possible, mitigating actions must be implemented eliminate the risk or to reduce the risk to an acceptable risk level.
Based on a well-defined and documented microbial contamination control strategy, it should be possible for manufacturers to implement a just-in-time microbiological release strategy. This Webinar will highlight microbial contamination control and testing strategies that can be employed throughout each stage of the manufacturing process that will allow for a potential just in time release of CAR T products.
Followed by an Industry Perspective presented by Lori Daane, Pharma Microbiology Scientific Director at bioMérieux
Lori Daane is the Director of Scientific Affairs at bioMérieux and has experience in clinical, environmental and industrial microbiology. She is a technical expert on Rapid and Alternative Methods and participates in the sourcing and evaluation of new technologies and potential partnerships in the field of microbial control. She provides scientific support to the Healthcare Business in North America and is responsible for managing feasibility testing and method development for bioMérieux instruments and culture media products.
Watch now
Viral Safety by Design for Cell and Gene Therapy Products
Nov 11 2019
67 mins
Mark Plavsic, Chief Technology Officer at Lysogene & Archie Lovatt, Life Sciences Biosafety Scientific Director at SGS
Together with product efficacy, product safety is an essential characteristic of any medicinal product including cell and gene therapy (C>) biologics. Adventitious agents (viruses, bacteria, mycoplasma, prions, etc) pose constant risk to these biologics, and, as such they may impact directly product and patient safety. It is therefore of supreme importance to intentionally (by design) employ effective measures across the whole C> product manufacturing process to mitigate risk of adventitious agents. This presentation will review various interconnected steps throughout the manufacturing process, from the raw materials to the fill and finish, that would, in concert, help mitigate the risk while providing a high degree of product safety by design.
Watch now
Pharmaceutical Forensics for Safe Manufacturing and Supply
Nov 6 2019
76 mins
Ravi Kalyanaraman and Jeremy Peters of BMS and Robert Heintz of Thermo Fisher Scientific
Why Use Raman Microscopy for Pharmaceutical Forensics?
by Dr. Robert Heintz, Senior Applications Specialist at Thermo Fisher Scientific
Raman microscopy is uniquely suited for providing essential information for pharmaceutical forensic applications. The use of visible lasers allows for analysis of very small samples with spatial resolutions down to a micron or better. Materials can be analyzed in glass containers and through transparent packaging. Mapping and imaging provides information on the spatial distribution of components as well as particle sizes and shapes. Confocal operation allows for probing inside transparent materials and analyze different layers or inclusions without the need to cut or cross-section the sample. Raman microscopy is non-destructive and preserves the sample for further analysis. Raman spectra can be used not only for the conformation of expected components but also the identification of unknown contaminants or impurities. Spectral features are very sensitive to molecular structure and can be used to distinguish polymorphs and other very chemically similar materials.
Followed by Pharmaceutical Forensics for Safe Manufacturing and Supply
by Ravi Kalyanaraman, Director at BMS
Pharmaceutical Investigations and Technology (PIT) is a group within Global Analytical Technology (GAT) department in the commercial Quality organization within Bristol-Myers Squibb. The PIT group has been a key part in BMS for 30 + years in providing analytical support for commercial manufacturing and in pharmaceutical forensics. This include particulate and foreign matter characterization in pharmaceutical products and screening counterfeit drugs. Several analytical tools and techniques are used by PIT to support the pharmaceutical forensics.This talk will feature all the analytical techniques used by PIT and how the results are used in resolving manufacturing issues and to protect patients from counterfeit drugs.
Watch now
Engineering First Principles: Applications to Pharmaceutical Manufacturing
Nov 5 2019
66 mins
Bernard McGarvey, PhD Chemical Engineering
Within the pharmaceutical industry, creating a robust Operational Control Strategy (OCS) is a key step to accomplishing the goals of Quality by Design (QbD). Along the way to developing this robust Operational Control Strategy many problems will be encountered that need to be solved. The use of a First Principles based approach provides value because it improves the effectiveness and efficiency of our problem solving, thereby leading to solutions that are more likely to work without unintended consequences and were created in a faster and more cost effective manner. Based on the author's experience, a clear definition of what First Principles are will be given (and what they are not!). Areas of opportunity where the application of First Principles is likely to be successful will be described. An outline of a high-level process for implementing a First Principles based approach will be presented. Finally an example of the application of First Principles in the pharmaceutical industry will be briefly described.
Watch now
Upstream Viral Risk Mitigation Strategy for High Titer Biologics Manufacturing
Oct 17 2019
83 mins
Aaron Mack, Engineer at Biogen & Dave Kolwyck, Director at Biogen and David Gemmell Senior Process Engineer at Merck
Presented by Aaron Mack, Engineer at Biogen
This talk will focus on the risk based approach that Biogen used for determining which raw materials to initially include in its upstream raw material viral risk mitigation portfolio. High Temperature Short Time (HTST) at raw material suppliers is an integral part of this risk mitigation approach. The merits of a risk-based approach to upstream viral safety will be explored, highlighting the HTST pasteurization viral mitigation capability suppliers like Merck have introduced and expanded. Treatment parameters have been detailed in publically available peer reviewed literature and confirmed in specific raw material components prior to implementation in commercial manufacturing processes. Additionally, benefits of decoupling materials with high risk of viral contamination will be reviewed.
Followed by Implementation of a Robust Upstream Viral Mitigation Strategy for Cell Culture Feeds
Presented by David Gemmell Senior Process Engineer at Merck (Contact at email@example.com)
High temperature short time (HTST) pasteurization is a highly effective method to achieve virus inactivation. This technology has been typically used as an in-house pretreatment tool for high risk bioreactor feeds. The availability of HTST-pretreated feeds minimizes the need to install complex and costly systems in the bioproduction facility, which have significant capital expenditure costs and can become a process bottleneck. The availability and use of complementary virus mitigation strategies minimizes the risk of introducing adventitious agents into the bioreactor, which can impact manufacturing operations and ultimately affect drug supply to patients.
The webinar details the products and capabilities Merck have developed regarding viral removal utilizing viral filtration or viral inactivation via High Temperature Short Time pasteurization, of high-risk raw material feeds for the biopharmaceutical industries.
Watch now
FDA Perspective on Aseptic Process Simulation for Cell Therapy Product Manufa...
Oct 16 2019
83 mins
Dr Lily Koo, Consumer Safety Officer at FDA and Dr Keen Chung, Principal Scientist (Upstream Process) at Pall Biotech
FDA Perspective on Aseptic Process Simulation for Cell Therapy Product Manufacturing
Presented by Dr Lily Koo, Consumer Safety Officer at Food and Drug Administration
The manufacturing processes for cell therapy products can be highly complex, non-conventional, and product-specific. Aseptic techniques are often required throughout manufacture. The challenge to appropriately and effectively validate aseptic processing requires that industry and regulatory bodies rethink how validation strategies are best applied to this novel class of products. This presentation will address FDA perspective on aseptic process simulation for cell therapy products. It will highlight some unique manufacturing/processing features that are shared among cell therapy products and should be considered during aseptic process simulation study design. The presentation will also cover elements of the traditional validation approach and how they could be appropriately applied to cell therapy manufacturing.
Followed by Process Control Strategy to Mitigate Contamination Risk of an Aseptic Viral Vector Production
Presented by Dr Keen Chung, Principal Scientist (Upstream Process) at Pall Biotech
Adeno-associated virus (AAV) vectors are potent gene therapy vectors, used to deliver therapeutic transgenes to target tissues. Gene therapy clinical trials often require high titer vector preparations to adequately deliver the therapeutic transgene, in great excess of research-level production utilized in many laboratories. To bring the virus into the pre-clinical and clinical phases, Pall Biotech simplified, optimized and scaled-up the current upstream and downstream process of viral vector production to industrial scales using the fully-closed, single-use Xpansion® multiplate seed train bioreactor and the production packed-bed iCELLis® 500 single-use bioreactor. In these processes, it is important to ensure that steps are built into the process to ensure adequate control of adventitious agents.
Watch now
Qualification of Raw Materials Used in the Manufacturing of Cellular Therapies
Oct 7 2019
80 mins
Jim Richardson, Sr Scientific Liaison at USP and Horst Ruppach, Ph.D. Scientific Director at Charles River
Presented by Jim Richardson, Sr Scientific Liaison at United States Pharmacopeia
Dr. Richardson works in the standards pipeline development group within Global Biologics at USP, leading efforts to develop standards for emerging technologies such as cell and gene therapy. In previous roles at Advanced BioScience Laboratories and Foundation Fighting Blindness, he led translational science activities for the development of vaccines and biologics to prevent and treat infectious and retinal diseases. Trained as a virologist, Jim has also held positions responsible for performing viral clearance testing at Viromed Biosafety and AAV vector development and characterization at Genovo/Targeted Genetics. Dr. Richardson earned his Ph.D. in Biomedical Sciences at the Mount Sinai School of Medicine.
Followed by Viral Safety Aspects of Raw Materials Used in the Production of Biologics Including Cellular Therapy Products
Presented by Horst Ruppach, Ph.D. Scientific Director Viral Safety at Charles River's Biologics Testing Solutions
After a short review of regulations/guidance related to viral safety aspects of raw materials the in principle concept for ensuring viral safety will be outlined. The viral risk profile of a raw material is defined based on the source material, the sourcing process and the subsequent manufacturing and/or purification process. Testing for viruses performed on the start material and/or process intermediates is one way to mitigate the viral risk. Different methods for testing will be presented and the pros and cons discussed. Analyzing the viral clearance capacity of the manufacturing process is another important strategy to reduce the viral risk significantly if applicable. There are, however, experimental challenges sometimes which makes it difficult to demonstrate efficient viral clearance even though the treatment is known to be highly efficient.
Watch now
Cost Considerations for the Application of Continuous Processing
Oct 2 2019
63 mins
Narasimha Rao Nedunuri, CEO of CLONZ Biotech and Tania Pereira Chilima, Product Manager at Univercells
Cost contribution of continuous manufacturing both in operational and capital expenditure in Monoclonal antibody production.
Evaluating cost of production per gram conventional fed batch vs continuous process.
Key considerations for adapting continuous process for the production of Biosimilar MAbs.
Presented by Narasimha Rao Nedunuri, CEO of CLONZ Biotech
Narasimha Rao Nedunuri is one of the founding members of CLONZ Biotech, a Biosimilar Monoclonal Antibody company based in Genome Valley, Hyderabad, India.
He is currently serving the company as the Managing Director & CEO .
Nedunuri, a Molecular Biologist turned Entrepreneur has 18 years of experience in the field of Life Sciences Research including Cancer Biology, Proteomics, and Molecular diagnostics. He also had business experience in a USA based company, with the responsibility of establishing a business division for its Indian subsidiary.
At CLONZ , a 7 year old start-up, along with the co-promoters coming from recognized leaders who launched complex Biosimilar MAbs, driving the company to emerge as a significant Global Biosimilar MAb company.
Followed by a presentation by Tania Pereira Chilima, Product Manager at Univercells
Tania Pereira Chilima is a Product Manager at Univercells, responsible for the NevoLine platform for cost-effective viral production. She completed her Bachelors' degree in Biochemical engineering with focus on protein manufacture at the University College London. She was then awarded an Engineering doctorate, also at the University College London, looking at building and applying decisional tools to help guide the cell therapy industry in selecting commercialization strategies (process, facility design, reimbursement strategies etc.). Her post-doc was sponsored by the Bill & Melinda Gates Foundation, focused on identifying the optimal manufacturing strategies to deliver low cost vaccines.
Watch now
The Journal for Asia's Pharmaceutical and Biopharmaceutical Industry
BioPharma Asia aims to keep its 30,000 readers abreast of all developments in the areas of Drug Development, Drug Delivery, Manufacturing, Quality Assurance, Outsourcing and Regulatory Affairs, with only the highest quality articles, written by the most respected authors, associated with only end-user companies. This ensures that the information will always be guaranteed to remain timely, informative and above all totally unbiased.
Upcoming webinars (45)
Recorded webinars (137)
Subscribers (12,532)
Channel RSS feed
Watch later
Watch later
You can now save presentations to a watch later list and revisit them at your convenience. Click on your profile menu to find your watch later list.
Got it
Viewing Certificate
Register for Free
Already have a BrightTALK account?
Log in
Recommended for you:
[[ webcast.title ]]
[[ webcast.presenters ]]
[[ webcast.start * 1000 | amDateFormat: 'MMM D YYYY h:mm a' ]]
[[ (webcast.duration / 60) | number:0 ]] mins
[[ webcast.title ]]
[[ webcast.presenters ]]
[[ webcast.start * 1000 | amDateFormat: 'MMM D YYYY h:mm a' ]]
[[ (webcast.duration / 60) | number:0 ]] mins
Embed in website or blog
Copy and paste this embed code to your website or blog:
Your colleagues' emails:
Successfully added emails:
Remove all
Your message:
Hi, I thought this webinar was interesting and I wanted to share it with you.
Title: Upstream Viral Risk Mitigation Strategy for High Titer Biologics Manufacturing
Live at:
Oct 17 2019 2:00 pm
Presented by: Aaron Mack, Engineer at Biogen & Dave Kolwyck, Director at Biogen and David Gemmell Senior Process Engineer at Merck
Your email has been sent.
Invite more colleagues
You are confirmed to attend for free on BrightTALK!
Save to your calendar to make sure you don't miss the live event
Add to calendar
Upstream Viral Risk Mitigation Strategy for High Titer Biologics Manufacturing
Aaron Mack, Engineer at Biogen & Dave Kolwyck, Director at Biogen and David Gemmell Senior Process Engineer at Merck
[[ webcastStartDate * 1000 | amDateFormat: 'MMM D YYYY h:mm a' ]]
82 mins