text:
GAINESVILLE, Fla. – Florida's offense has been mostly stagnant since the Tim Tebow era.
The Gators have spent the last three seasons near the bottom of the country in total offense, failing to create big plays and struggling to find consistent playmakers.
It's been a head-scratching issue in Gainesville — one that was somewhat overlooked last year thanks to 11 wins and a dominant defense — and a troubling trend the Gators would like to reverse in offensive coordinator Brent Pease's second season.
"We need to be more balanced on offense," coach Will Muschamp said. "We need to be more efficient throwing the football. We need to be able to create more explosives. We need to score more touchdowns in the red zone."
Pease agrees, pointing out several reasons he believes the offense will be better in 2013. He expects quarterback Jeff Driskel, who's recovering from an appendectomy, will make strides in his second year as the starter. He thinks the offensive line will provide better protection with the return of three starters and the addition of transfers Max Garcia and Tyler Moore. And he anticipates the receivers flourishing under newcomer Joker Phillips, who has 18 years of experience as a receivers coach.
And then there's the whole Year 2 thing, when players are expected to have a better grasp of the offense and its concepts.
"The kids understand the calls, but they understand the calls for a reason: How we're trying to attack the defense, where we're vulnerable at times and what they have to do to make it work or getting ourselves into the correct play," Pease said Wednesday. "The kids are playing confident. There's more instinct with what they're doing. They understand the calls. They're not thinking. It's more reactionary now."
The Gators were one of the most dynamic teams in the country during Tebow's tenure (2006-09), moving the ball on just about every defense and scoring points in flurries.
But Florida's offense came to a screeching halt without the 2007 Heisman Trophy winner.
The Gators ranked 82nd in the nation in total offense in 2010 and fell to 105th in 2011. They weren't much better in Pease's first season, finishing 103rd in total offense and 114th in passing. Florida averaged 334 yards a game and scored 35 offensive touchdowns in 2012 — about 100 yards and at least 20 TDs shy of Tebow's heyday.
The most noticeable difference was the lack of big plays, especially in the passing game.
Florida has just one 300-yard passing game — John Brantley against lower-division Furman in 2011 — in its last 39 outings. That's one 300-yard passer in the last 1,315 days. By contrast, the Gators had 53 300-yard passing days in former coach Steve Spurrier's 12-year tenure.
Sure, Muschamp runs a completely different offense, a run-first scheme designed to wilt defenses into submission.
But when the Gators have tried or needed to pass, it's been a problem. No one at Florida wants to point fingers, but it was clear last season that Driskel had accuracy issues, that receivers ran imprecise routes and that the offensive line wasn't solid against formidable fronts.
"We're going to have to throw the ball more and we'll have to be more efficient throwing the ball," Driskel said. "We're going to have to hit more big plays. We can't run the ball 50 times a game like we did last year at points. We're still going to run the ball effectively and we have an offensive line that loves running the ball, and we have some explosive backs. That's still going to be a big part of our game, but we do have to make more plays throwing the ball, which I think we'll do."
Of course, that depends on Driskel, his protection and, maybe most importantly, finding playmakers at receiver.
The Gators are counting on contributions from freshmen Ahmad Fulwood and Demarcus Robinson. But of the 61 true freshmen receivers who have played at Florida since 1990, only four — Reidel Anthony (1994), Ike Hilliard (1994), Andre Caldwell (2003) and Percy Harvin (2006) — have caught more than seven passes in their first year.
"The freshmen are very talented kids," Pease said. "Now, the knowledge of just learning their plays consistently and understanding what all the calls are is where the mistakes come from. But as far as running and catching and their abilities, they are a very, very talented group."

subset: commoncrawl


text:
This chapter describes the features provided by the WebLogic Diagnostics Framework (WLDF) for generating, gathering, analyzing, and persisting diagnostic data from WebLogic Server instances and from applications deployed to them. For server-scoped diagnostics, some WLDF features are configured as part of the configuration for a server in a domain. Other features are configured as system resource descriptors that can be targeted to servers (or clusters). For application-scoped diagnostics, diagnostic features are configured as resource descriptors for the application.
This chapter includes the following sections:
Configuring Diagnostic Image Capture and Diagnostic Archives
Configuring Diagnostic Image Capture for JRockit Flight Recorder
WLDF Configuration MBeans and Their Mappings to XML Elements
For general information about WebLogic Server domain configuration, see Understanding Domain Configuration for Oracle WebLogic Server.
As in other WebLogic Server subsystems, WLDF is configured using configuration MBeans (Managed Beans), and the configuration is persisted in XML configuration files. The configuration MBeans are instantiated at startup, based on the configuration settings in config.xml. When you modify a configuration by changing the values of MBean attributes, those changes are saved (persisted) in the XML files.
Configuration MBean attributes map directly to configuration XML elements. For example, the Enable attribute of the WLDFInstrumentationBean maps directly to the <enabled> sub-element of the <instrumentation> element in the resource descriptor file (configuration file) for a diagnostic module. If you change the value of the MBean attribute, the content of the XML element is changed when the configuration is saved. Conversely, if you were to edit an XML element in the configuration file directly (which is not recommended), the change to an MBean value would take effect after the next session is started.
For more information about WLDF Configuration MBeans, see WLDF Configuration MBeans and Their Mappings to XML Elements. For general information about how MBeans are implemented and used in WebLogic Server, see "Understanding WebLogic Server MBeans" in Developing Custom Management Utilities With JMX for Oracle WebLogic Server.
As with other WebLogic Server subsystems, there are several ways to configure WLDF:
Use the Administration Console to configure WLDF for server instances and clusters. See "Configure the WebLogic Diagnostics Framework" in the Administration Console Online Help.
Write scripts to be run in the WebLogic Scripting Tool (WLST). For specific information about using WLST with WLDF, see Appendix D, "WebLogic Scripting Tool Examples." Also see Oracle WebLogic Scripting Tool for general information about using WLST.
Configure WLDF programmatically using JMX and the WLDF configuration MBeans. See Chapter 16, "Configuring and Using WLDF Programmatically," for specific information about programming WLDF. See Oracle WebLogic Server MBean Reference and browse or search for specific MBeans for programming reference.
Edit the XML configuration files directly. This documentation explains many configuration tasks by showing and explaining the XML elements in the configuration files. The XML is easy to understand, and you can edit the configuration files directly, although it is recommended that you do not. (If you have a good reason to edit the files directly, you should first generate the XML files by configuring WLDF in the Administration Console. Doing so provides a blueprint for valid XML.)
If you make changes to a configuration by editing configuration files, you must restart the server for the changes to take effect.
You can use WLDF to perform diagnostics tasks for server instances (and clusters) and for applications.
You configure the following WLDF components as part of a server instance in a domain. The configuration settings are controlled using MBeans and are persisted in the domain's config.xml file.
Diagnostic Image Capture
Diagnostic Archives
See Configuring Diagnostic Image Capture and Diagnostic Archives.
You configure the following WLDF components as the parts of one or more diagnostic system modules, or resources, that can be deployed to one or more server instances (or clusters). These configuration settings are controlled using Beans and are persisted in one or more diagnostic resource descriptor files (configuration files) that can be targeted to one or more server instances or clusters.
Harvester (for collecting metrics)
Watch and Notification
You can use the WLDF Instrumentation component with applications, as well as at the server level. The Instrumentation component is configured in a resource descriptor file deployed with the application in the application's archive file. See Configuring Diagnostic Modules for Applications.
In the config.xml file for a domain, you configure the Diagnostic Image Capture component and the Diagnostic Archive component in the <server-diagnostic-config> element, which is a child of the <server> element in a domain, as shown in Example 4-1.
Example 4-1 Sample WLDF Configuration Information in the config.xml File for a Domain
<domain> <server> <name>myserver</name> <server-diagnostic-config> <image-dir>logs/diagnostic_images</image-dir> <image-timeout>3</image-timeout> <diagnostic-store-dir>data/store/diagnostics</diagnostic-store-dir> <diagnostic-data-archive-type>FileStoreArchive </diagnostic-data-archive-type> </server-diagnostic-config> </server> <!-- Other server elements to configure other servers in this domain --> <!-- Other domain-based configuration elements, including references to WLDF system resources, or diagnostic system modules. See Example 4-2. --> </domain>
If WebLogic Server is configured with Oracle JRockit, and JRockit Flight Recorder is enabled, the diagnostic image capture can optionally include a JRockit Flight Recorder (JFR) file that includes WebLogic Server events. The JFR file can then be viewed in JRockit Mission Control.
For more information, see the following:
If WebLogic Server is configured with Oracle JRockit R28 or later, and JRockit Flight Recorder is not explicitly disabled, the JFR file is automatically included in the diagnostic image capture. The JFR file contains data from all event producers that are enabled. However, the amount of WebLogic Server event data that is included in the JFR file is determined by the configuration of the WLDF diagnostic volume.
By default, the WLDF diagnostic volume is set to
To include WebLogic Server event data in the JFR file:
Ensure that WebLogic Server is configured with Oracle JRockit R28, which is available from the WebLogic Server installation program.
For information, see Installation Guide for Oracle WebLogic Server.
Ensure that JFR flight recording is not disabled in JRockit.
In a default installation of Oracle JRockit, Flight Recorder operates in Default Data Gathering Mode. No JRockit settings are required to have JVM events included in the JFR file.
For information, see Oracle JRockit Flight Recorder Run Time Guide.
Set the WLDF diagnostic volume as appropriate. For general use, Oracle recommends the default setting of
Low. However, you can increase the volume of WebLogic Server event data that is generated, as appropriate, by setting the volume to
Medium or
Note that the WLDF diagnostic volume setting has no impact on data recorded for other event producers, such as the JVM.
For information, see "Configure WLDF diagnostic volume" in Oracle WebLogic Server Administration Console Online Help.
If the WLDF diagnostic volume is set to
Off, and Flight Recorder has not been explicitly disabled, the JFR file continues to include JVM event data and is always included in the diagnostic image capture.
To configure and use the Instrumentation, Harvester, and Watch and Notification components at the server level, you must first create a system resource called a diagnostic system module, which will contain the configurations for all those components. Keep in mind that:
System modules are globally available for targeting to servers and clusters configured in a domain.
In a given domain, you can create multiple diagnostic system modules with distinct configurations.
At most, one diagnostic system module can be targeted to any given server or cluster.
You create a diagnostic system module through the Administration Console or the WebLogic Scripting Tool (WLST). It is created as a WLDFResourceBean, and the configuration is persisted in a resource descriptor file (configuration file), called DIAG_MODULE.xml, where DIAG_MODULE is the name of the diagnostic module. You can specify a name for the descriptor file, but it is not required. If you do not provide a file name, a file name is generated based on the value in the descriptor file's <name> element. The file is created by default in the DOMAIN_NAME\config\diagnostics directory, where DOMAIN_NAME is the name of the domain's home directory. The file has the extension .xml.
The diagnostic module conforms to the diagnostics.xsd schema, available at
For instructions on creating a diagnostic system module, see "Create diagnostic system modules" in the Oracle WebLogic Server Administration Console Online Help.
When you create a diagnostic system module using the Administration Console or the WebLogic Scripting Tool (WLST), WebLogic Server creates it in DOMAIN_NAME/config/diagnostics, and a reference to the module is added to the domain's config.xml file.
Oracle recommends that you do not write XML configuration files directly. But if you have a valid reason to do so, you should first create a diagnostic module from the Console. That way, you can start with the valid XML that the Console creates. For instructions, see "Create diagnostic system modules" in the Oracle WebLogic Server Administration Console Online Help.
The config.xml file can contain multiple references to diagnostic modules, in one or more <wldf-system-resource> elements. The <wldf-system-resource> element includes the name of the diagnostic module file and the list of servers and clusters to which the module is targeted.
For example, Example 4-2 shows a config.xml file with a module named myDiagnosticModule targeted to the server myserver and another module named newDiagnosticMod targeted to servers ManagedServer1 and ManagedServer2.
Example 4-2 Sample WLDF Configuration Information in the Config.xml File for a Domain
<domain> <!-- Other domain-level configuration elements --> <wldf-system-resource xmlns="http://xmlns.oracle.com/weblogic/weblogic-diagnostics"> <name>myDiagnosticModule</name> <target>myserver</target> <descriptor-file-name>diagnostics/MyDiagnosticModule.xml </descriptor-file-name> <description>My diagnostic module</description> </wldf-system-resource> <wldf-system-resource> <name>newDiagnosticMod</name> <target>ManagedServer1,ManagedServer2</target> <descriptor-file-name>diagnostics/newDiagnosticMod.xml </descriptor-file-name> <description>A diagnostic module for my managed servers</description> </wldf-system-resource> <!-- Other WLDF system resource configurations --> </domain>
The relationship of the config.xml file and the MyDiagnosticModule.xml file is shown in Figure 4-1.
Figure 4-1 Relationship of config.xml to System Descriptor File
Except for the name and list of targets, which are listed in the config.xml file, as described above, all configuration for a diagnostic system module is saved in its resource descriptor file. Example 4-3 shows portions of the descriptor file for a diagnostic system module named myDiagnosticModule.
Example 4-3 Sample Structure of a Diagnostic System Module Descriptor File, MyDiagnosticModule.xml
<wldf-resource xmlns="http://xmlns.oracle.com/weblogic/weblogic-diagnostics"
<!-- Configuration elements for zero or more diagnostic monitors -->
<!-- Configuration elements for harvesting metrics from zero or more
MBean types, instances, and attributes -->
<!-- Configuration elements for one or more watches and one or more
A diagnostic system module can be targeted to zero, one, or more servers or clusters, although a given server can have only one module targeted to it at a time. You can create multiple modules that monitor different aspects of your system. You can then choose which module to target to a server or cluster, based on what you want to monitor at that time.
Because you can target the same module to multiple servers or clusters, you can write general purpose modules that you want to use across a domain.
You can change the target of a diagnostic module without restarting the server instance(s) to which it is targeted or untargeted. This gives you considerable flexibility in writing and using diagnostic monitors that address a specific diagnostic goal, without interfering with the operation of the server instances themselves.
See the following sections for detailed instructions on configuring WLDF system resources:
You can configure only the Instrumentation component in a diagnostic descriptor for an application.
You configure and deploy application-scoped instrumentation as a diagnostic module, which is similar to a diagnostic system module. However, an application module is configured in an XML descriptor (configuration) file named weblogic-diagnostics.xml, which is packaged with the application archive in the ARCHIVE_PATH/META-INF directory for the deployed application. For example, D:\bea\wlserver_12.1\samples\server\medrec\dist\standalone\exploded\medrec\META-INF\weblogic-diagnostics.xml
The DyeInjection monitor, which is used to configure diagnostic context (a way of tracking requests as they flow through the system), can be configured only at the server level. But once a diagnostic context is created, the context attached to incoming requests remains with the requests as they flow through the application. For information about the diagnostic context, see Chapter 12, "Configuring the DyeInjection Monitor to Manage Diagnostic Contexts."
For more information about configuring and deploying diagnostic modules for applications, see:
Figure 4-2 shows the hierarchy of the WLDF configuration MBeans and the diagnostic system module beans for WLDF objects in a WebLogic Server domain.
Figure 4-2 WLDF Configuration Bean Tree
The following WLDF MBeans configure WLDF at the server level. They map to XML elements in the config.xml configuration file for a domain:
WLDFServerDiagnosticMBean controls configuration settings for the Data Archive and Diagnostic Images components for a server. It also controls whether diagnostic context for a diagnostic module is globally enabled or disabled. (Diagnostic context is a way to uniquely identify requests and track them as they flow through the system. See Chapter 12, "Configuring the DyeInjection Monitor to Manage Diagnostic Contexts.")
This MBean is represented by a <server-diagnostic-config> child element of the <server> element in the config.xml file for the server's domain.
WLDFSystemResourceMBean contains the name of a descriptor file for a diagnostic module in the DOMAIN_NAME/config/diagnostics directory and the name(s) of the target server(s) to which that module is deployed.
This MBean is represented by a <wldf-system-resource> element in the config.xml file for the domain.
You can create multiple diagnostic system modules in a domain. The configurations for the modules are saved in multiple descriptor files in the config/diagnostics directory for the domain. The domain's config.xml file, therefore, can contain the multiple <wldf-system-resource> elements that represent those modules. However, you can target only one diagnostic system module to a server at a time. You cannot have two files in the config/diagnostics directory whose active target is the same server.
WLDFResourceBean contains the configuration settings for a diagnostic system module. This bean is represented by a <wldf-resource> element in a DIAG_MODULE.xml diagnostics descriptor file in the domain's config/diagnostics directory. (See Figure 4-1 and Example 4-3.) The WLDFResourceBean contains configuration settings for the following components:
Harvester: The WLDFHarvesterBean is represented by the <harvester> element in a DIAG_MODULE.xml file.
Instrumentation: The WLDFInstrumentationBean is represented by the <instrumentation> element in a DIAG_MODULE.xml file.
Watch and Notification: The WLDFWatchNotificationBean is represented by the <watch-notification> element in a DIAG_MODULE.xml file.
If a WLDFResourceBean is linked from a WLDFSystemResourceMBean, the settings for WLDF components apply to the targeted server. If a WLDFResourceBean is contained within a weblogic-diagnostics.xml descriptor file which is deployed as part of an application archive, you can configure only the Instrumentation component, and the settings apply only to that application. In the latter case, the WLDFResourceMBean is not a child of a WLDFSystemResourceMBean.


text:
This post originally appeared at Campaign for America's Future (CAF) at their Blog for OurFuture. I am a Fellow with CAF.
Last month Former Senator and Deficit Commission co-chair Alan Simpson said this about Social Security, and by extension about government itself,
"We've reached a point now where it's like a milk cow with 310 million tits!"
Nice. We work and pay into Social Security all our lives, we pay our taxes, but when it comes time to retire our leaders say we're nothing more than freeloaders sucking off the tits of the "milk cow."
The Deficit Commission is meeting today and the National Organization for Women showed up and delivered 1,500 nipples to Simpson's commission. They called it "1500 Tits for an Ass."
From NOW's press release,
"The Fiscal Commission should be led by someone who will actually try to address the federal budget deficit, instead of using it as an excuse to undermine Social Security by cutting benefits or raising the retirement age," O'Neill continues. "Alan Simpson is not that person."
Especially Women!
Social Security is especially important to women because women still are paid less than men and can't save as much for retirement, tend more than men to be in jobs without any pension (only 13 percent of women aged 65 or older currently receive a pension) and women are more likely to be on their own: single, widowed or divorced by retirement age. In fact 42 percent of women over age 62 relied on Social Security for 90 percent or more of their income, compared to 28 percent of men. Any cuts in the program would hit women particularly hard.
Here is video from the delivery:
Social Security is involved in this because, even though the program is fully funded and by law is not allowed to borrow, which means it cannot contribute to the deficit, the program will one day need to draw on its huge trust fund, and the government will have to find ways to come up with the money owed.
This is all outrageous enough, but now word is leaking out that Republicans on the commission have refused to even discuss addressing the revenue shortfall with more revenue, and in fact are pressing for the commission to recommend even more tax cuts.
According to one source familiar with the deliberations, Republicans were even opposed to eliminating loopholes, exemptions, credits and other so-called "tax expenditures" unless the associated revenue increase could be used to lower capital gains and corporate income rates.
"Republicans have not even said that we should get any revenue from taxes," the source said. "Even tax expenditures. They appear to want to use the savings on tax expenditures to cut corporate taxes. So shared sacrifices — except for large corporations who make out even better."
Simpson Not All That Is Unbalanced
The commissions members were biased toward the right going into this with many members having made previous statements showing they want to cut or privatize Social Security. In addition billionaire Pete Peterson, who is funding a campaign to privatize Social Security, is supplying staff to the commission.
Preempt The Commission!
So the results of a stacked commission are starting to show up. Congress needs to act to preempt the commission from cutting Social Security. Congress: Act Now To Preempt The Catfood Commission


text:
65 years ago, Jack Wainright's FHS band won a national title
First Annual Competition Schools Band contest of America, Chicago, Ill. 1023 Fostoria (Ohio) High School Winner of Blue Ribbon and Capital Prize of $1,000 Pix #2 - Captain W.H. Santelman, Director of U.S. Marine Bane, pinning the Blue Riggon on Jack Wainwright, after the F.H.S. Band was judged the winner in Chicago in 1923.
(Author's Note: How did I know that , and why does today's article happen to be in print" Here's why!
some weeks ago Richard Reis, Mesa, Arizona, son of Mr. and Mrs. Virgil Reis, E. Fremont St., sent he presented a printed article from Music Education Journal, February, 1988 issue, all about music in schools, going back to the time when Jack Wainwright was pioneering instrumental music at Fostoria High, and culminating with Jack's F.H. S. band winning the first National School Band contest in Chicago in 1923.
At about that same time someone who did not leave his or her name, brought to The Review Times, the large photo used with today's article, showing the F.H. band when they won the National Championship in 1923 in Chicago.
the donor of the photo only said, "perhaps Paul Krupp might be able to use it in an article."
Today's article and one or two more will be devoted to that championship band of 65 years ago.)
How lucky can I be?
On top of all that, I discovered in a conversation with Fostorian Jim Carter, a member of that 1923 band that he had a sizable file about Wainwright and the band going back to those early years.
And through some effort it has been possible to collect photos of those early members of Jack Band who are still living.
I hope you enjoy this series.
Other than the above explanation, of course, this author was attending F.H.S. in 1923, graduating that year, just prior to the band winning the contest, and remember the preparation for the contest and the "win" that followed.
Blue ribbon means 'best'
Yes, it was sixty five years ago (in 1923) that Jack Wainwright and the 62-piece Fostoria High School Band went to Chicago to participate in the contest to decide the best school band in the U.S.A., and they won the title "best."
That was a readt day for those young musicians and for their parents, schoolmates and the whole town. And when they returned home a large crowd was at the railroad station to welcome and praise them. Hundreds were present when the train pulled in.
Fostoria had always been strong for music in earlier years, but that victory was the crowning achievement for Jack and his young musicians.
Members of 'best' band
In the event that names cannot be matched with all of the faces of the musicians that participated in that contest, as shown in the photo with today's article here is the complete list, grouped according to the instruments played:
Trumpets: Arvine Harrold, Richard Conley, Wm. Franke, Kenneth Hooper, Harrison Scott, Marvine Hoffman, Wm. Richards, Charles Sterns, Byron Stearns, Glenn Hill James Carter, James Richards.
Trombones: Robert Warren, Calvin Frances, Leland Cribbs, Robert Myers, Guy Workman, John Yeasting.
Baritone: Howard Wikle, Norman Munech, Dan Warren.
Flute and Piccolo: Lawrence Bredbeck, Walter Bristow, Royal McCracken, Victor Myers.
French Horn: Lyndon Abbott, Ralph Cramer, John Reed, Mahlon Sheller, John Hayfield, Russel Simon, Wm. Lockhart.
Saxophone: Junior Myers, Myron Leibengod, Paul Stein, Clyde Smith.
Tuba: George Green, Orin Carroll, Claire Crunkiltom, Harold Hartley, Raymond Cole,
cymbals: Howard Baynton.
Drums: Grenville Hearst, Charles Hunt, Ralph Sackett, Don Sheldon, Charles Carroll.
Clarinets: Howard St. John, Wilbur Shults, George Schlatter, Virgil Switzer, Walter May, Harry Hale, Robert Shaffer, Homer Spangler, Joseph Arnold, John Weaver, Wad Loe, Thomas Wirebaugh.
Drum Major: Park Burtcher.
(To be continued next week.)
Heed God's Word: A warning for American Christians
Dr. D. James Kennedy of Coral Ridge Ministries quoted General Douglas MacArthur in a recent bulletin:
"History fails to record a single precedent in which nations subject to moral decay have not passed into political and economic decline. There has been either a spiritual awakening to overcome the moral lapse, or progressive deterioration leading to ultimate national disaster."(MacArthur)
"General MacArthur's words are a chilling warning to us as American, But God's warning to us as Christians in Ezekiel 22A:30 is inescapable: 'And I sought for a man among them that should make up the hedge, and stand in the gap before me for the land, that I should not destroy it!'
"Yes, God is seeking men and women to stand in the gap for Him, in order to stay His judgment fir our land. Back in the 22nd chapter of Ezekiel, God didn't find that man or woman and his judgment was 70 years of Babylonian tyranny over Judah.
"You and I, as Christians, cannot ignore the responsibility we have to help win souls. We are so directed to make sure that whole counsel of God permeates our lives and our actions."
That warning pertains to Fostoria and every other town and city in the U.S.A.
It's time for a great awakening and revival.
Reader feed back: I'm sorry to have missed more doctors
Ever heard the expression, "Comedy of Errors?"
That is what POTLUCK has committed in handling the up-date on the latest list of doctors.
When the May 12th column was published, soon my telephone started ringing , with callers telling me that so and son's name was missed.
Gerald Windau told me the name of Dr. Overhold was not listed. And someone else called to report that Dr. J.L. Murphy's name was also omitted.
Alibis are not in order. I'll just say "I'm sorry."
Ever day when I walk up N. Main St., I think of Dr. Overholt. He lived there at one time.
Also, I remember when Dr. Murphy came to town and his first office was on West Center Street in a building which had once been a residence.
Yes. I remember where many of the doctors who were here many years ago had their offices. Again, I say I'm sorry.


text:
A technology called Legal Intercept that Microsoft hopes to patent would allow the company to secretly intercept, monitor and record Skype calls. And it's stoking privacy concerns.
Microsoft's patent application for Legal Intercept was filed in 2009, well before the company's $8.5 billion purchase of Skype in May. The patent application, which is still in process, was made public last week.
From Microsoft's description of the technology in its patent application, Legal Intercept appears similar to tools used by telecommunication companies and equipment makers to comply with government wiretap and surveillance requests.
According to Microsoft, Legal Intercept is designed to silently record communications on VoIP networks such as Skype.
"Data associated with a request to establish a communication is modified to cause the communication to be established via a path that includes a recording agent." The recording agent is then able to "silently record" the communication, according to Microsoft's description.
"Modification may include, for example, adding, changing, and/or deleting data within the data. The data as modified is then passed to a protocol entity that uses the data to establish a communication session," the description notes.
According to Microsoft, Legal Intercept addresses gaps in current monitoring tools that are designed mainly for intercepting Plain Old Telephone Service (POTS). "With new Voice over Internet Protocol (VoIP) and other communication technology, the POTS model for recording communications does not work," Microsoft noted in the patent application.
Michael Froomkin, a professor of law at the University Of Miami School Of Law, said that from the patent description it sounds as if the technology would allow Microsoft to do is make Skype CALEA capable.
CALEA (Communications Assistance for Law Enforcement Act) requires telecommunications carriers and makers of communications equipment to enable their equipment so it can be used for surveillance purposes by federal law enforcement agencies.
But the implications of the technology are much broader, Froomkin added. "First, making a communication technology FBI-friendly means also making it dictator-friendly, and in the long run this is not good for movements like the Arab Spring," he said. "Second, experience shows that building in back doors invites exploits."
Skype has also been somewhat cagey about whether it's had a CALEA-style back door all along, he said. "Skype doesn't fully disclose how it works or how it encrypts," Froomkin said. "As a result users must take a great deal on faith.
"History teaches us over and over that faith is very easily misplaced," he added.
Jeffrey Chester, executive director of the Center for Digital Democracy, said the technology aligns with Microsoft's broader goals.
The company "aims to incorporate tracking technologies for its Skype services, as it aggressively expands its mobile advertising system across the world," Chester said. "Skype will likely soon have ad targeting and user profiling digit strings attached. This underscores the need for strong mobile and location privacy safeguards," he said.
A Microsoft spokesman said the company would not comment on the technology.
Jaikumar Vijayan covers data security and privacy issues, financial services security and e-voting for Computerworld. Follow Jaikumar on Twitter at @jaivijayan or subscribe to Jaikumar's RSS feed . His e-mail address is firstname.lastname@example.com .
Read more about privacy in Computerworld's Privacy Topic Center.


text:
Browse Newsroom
December 1, 2022
Barbeque, Gumbo, Ice Cream and Team USA – America Leads with our Best at the FIFA World Cup
USDA's Foreign Agricultural Service is tapping into the uniting experiences of food and sports by shining a spotlight on high-quality, safe, delicious, and sustainably produced U.S. foods during the 2022 FIFA World Cup, underway in Qatar.
U.S. products took center stage in Guadalajara May 17-19 at Mexico's largest annual food industry trade show. FAS Administrator Daniel Whitley was there to lend his support.
May 18, 2022
U.S. Potatoes Return to Mexico
It looks like U.S. potatoes will soon be back on menus and at markets across Mexico! FAS Administrator Daniel Whitley marked the milestone in Guadalajara on May 17.
As part of USDA's commitment to expanding and diversifying global market opportunities for U.S. agriculture, the Department will sponsor four additional international trade missions in 2022,
Throughout 2021, FAS was proud to support USDA's efforts to create more and better markets for U.S. agriculture, to address the climate crisis, and to promote nutrition and food security.
Secretary Vilsack highlights key USDA accomplishments – including FAS's global leadership – to create more and better markets for U.S. agriculture in 2021.
December 16, 2020
FAS Keeps U.S. Agriculture Connected to the World in 2020
WASHINGTON, Dec. 16, 2020 – Despite the challenges 2020 brought, the Foreign Agricultural Service (FAS) continued to lead the U.S. Department of Agriculture's pursuit of global trade opportunities for American agriculture, successfully delivering on...
December 17, 2019
Under Secretary McKinney Discusses 2020 USDA Ag Trade Missions
Seven USDA-led Agricultural Trade Missions are scheduled for next year in continuing efforts to increase export opportunities. USDA Radio's Rod Bain talks to Under Secretary for Trade and Foreign Agricultural Affairs Ted McKinney about the 2020 trade...
U.S. Deputy Secretary of Agriculture Stephen Censky led a successful trade mission to West Africa, October 28-31, where he helped U.S. exporters unlock new opportunities in the region and advocated for the Administration's Prosper Africa initiative...
November 5, 2019
Secretary Perdue Leads USDA Trade Mission to Mexico
Washington, D.C., November 5, 2019 – U.S. Secretary of Agriculture Sonny Perdue will lead a trade mission to Mexico November 6-8 to forge new opportunities with U.S. agriculture's largest bilateral trading partner and second-largest export market...
October 25, 2019
Deputy Secretary Censky Leads Trade Mission to West Africa
Contact: email@example.com Washington, October 25, 2019 – U.S. Deputy Secretary of Agriculture Stephen Censky will lead a trade mission to West Africa, October 28-31, to help United States exporters unlock new opportunities in a region where strong...
October 11, 2019
USDA's McKinney Leads Mission to Tap Trade Opportunities in Vietnam
CONTACT: email@example.com or (202) 720-7115 WASHINGTON, Oct. 11, 2019 – When Under Secretary for Trade and Foreign Agricultural Affairs Ted McKinney leads a U.S. Department of Agriculture trade mission to Vietnam Oct. 15-18, he'll be accompanied by...


text:
More than 500 restaurateurs from across the country will convene in Washington April 17-18 for the National Restaurant Association's 27th annual Public Affairs Conference, which will feature Majority Whip of the U.S. House of Representatives Congressman Kevin McCarthy, as well as political consultant veterans Paul Begala and Alex Castellanos.
Congressman McCarthy represents the 23rd District of California, which spans Kern, Tulare, and Los Angeles counties. First elected in 2006, he is a native of Bakersfield and a fourth-generation Kern County resident. After the 2010 midterm elections, McCarthy was elected by his colleagues to serve as Majority Whip.
Begala, a political analyst for CNN, was a counselor to President Clinton. At the White House, he helped define the Administration's agenda on economic, domestic, and international issues. He has advised political campaigns throughout the country and around the world, including Europe, Latin America, the Caribbean, and Africa. At CNN, he is part of the political team that won an Emmy for its coverage of the 2006 elections and a Peabody Award for its coverage of the 2008 presidential election. He also is a columnist for Newsweek and The Daily Beast.
Castellanos is one of the Republican Party's best-known and most successful media consultants and strategists. He was a media consultant to seven U.S Presidential campaigns and helped elect nine U.S. senators and six governors. He has more than 20 years of political consulting experience in the United States and abroad, including campaign strategy, public opinion research, and communications experience.
The 2013 public affairs conference theme, "Carry the Message – America Works Here," is part of the National Restaurant Association's ongoing campaign to tell the industry's story as a leading job creator to opinion leaders. The restaurant industry is the nation's second-largest private sector employer of more than 13 million individuals and an engine of economic growth. The America Works Here slogan encompasses the industry's workforce, its diversity and the opportunity the industry provides, as well as the integration of the business into Americans' daily routines. The nation's nearly one million restaurants serve 130 million people every day.
During Capitol Hill meetings, conference attendees will provide members of Congress and staff with first hand experiences, articulating the need for pro-growth policies, including tax and immigration reforms, as well as reforms to the 2010 health care law.
The conference agenda also includes the Gala Restaurant Industry Awards Program honoring the winners of the 2013 Faces of Diversity and Restaurant Neighbor awards.
News and information presented in this release has not been corroborated by WTWH Media LLC.


text:
NEW YORK (AP) — AT&T says any cellphone customer can sign up for unlimited data plans starting Friday. That option had been limited to customers of AT&T-owned DirecTV.
The change comes just days after Verizon announced an unlimited plan without such restrictions.
All four major cellphone providers now offer unlimited plans, a major reversal from a few years ago. AT&T's version costs the same as Verizon's — $180 — for a family of four but is pricier for an individual. Sprint and T-Mobile are cheaper.
Sprint also said Thursday that it's letting unlimited customers watch video in high definition rather than DVD quality. T-Mobile announced a similar change Monday after Verizon said HD video was included. AT&T's unlimited plan degrades video to DVD quality, but customers can turn HD video back on for free.
Copyright 2023 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
I'd like to create icons for the endpoints of a process, but I'm not sure what to use.
Going with "A" and "B" comes to mind as that's a familiar reference (e.g. "the shortest distance from A to B") but I would prefer to leave that as a last resort.
Any good alternatives out there?


text:
CHARLOTTE, N.C., April 8 (UPI) -- The bodies of two young cousins were found in the rubble of a collapsed construction site in North Carolina's Lincoln County early Monday, officials said.
Rescue workers found the body of a 6-year-old girl at about 6 a.m., and the body of a 7-year-old boy about an hour later, The Charlotte (N.C.) Observer reported.
Lincoln County Emergency Management spokesman Dion Burleson said the children were found under about 24 feet of dirt in an excavated site about 20 miles northwest of Charlotte.
"These are horrific circumstances," Burleson said.
Burleson said the children were playing in a dug out area of the construction site Sunday evening while the boy's father was operating a backhoe nearby.
A wall in the hole collapsed and buried the children.
"There were several thousand pounds of dirt on top of them," said Lincoln County Sheriff David Carpenter.
More than 100 people worked to recover the bodies, Burleson said.
"We worked as if they were alive," Burleson said.
Burleson said the sheriff's office would investigate what exactly happened at the construction site.
"We have not determined what the father was building," he said. "This is a time of grieving for the family. Our investigation will go forward, but we also are allowing the family to deal with what has happened here."


text:
5 Ways to Redo a Vintage Trailer
Making over a vintage trailer probably isn't something that most of us are going to have a chance to do…but you never know! What I do know is that I love it when I see someone take something old and fix it up to give it a new start at life. So, seeing these once-forgotten camping trailers made fresh and pretty just makes me happy! Have fun peeking inside these sweet little homes on wheels as I show you 5 Ways to Redo a Vintage Trailer.


text:
Contaminated products contain chicken and duck breast products sourced from China.
Arthur Dogswell LLC, a pet food and treat manufacturer based in Los Angeles, has voluntarily recalled its chicken breast and duck breast jerky under the Breathies, Happy Heart, Happy Hips, Mellow Mut, Shape Up, Veggie Life, Vitality and Vitakitty brands that are labeled with a "best before" date of Jan. 29, 2015, or any earlier date. The jerky products were found to contain trace amounts of an antibiotic residue that is not approved for use in the United States.
Contamination of Dogswell Happy Hips Chicken Breast Jerky was discovered during routine testing by the New York State Department of Agriculture and Markets the week of July 22, prompting the company to recall all of the aforementioned chicken breast and duck breast jerky products. The company says the majority of the affected products were distributed before March 1 this year.
Dogswell says it began implementing new testing procedures to detect unapproved antibiotics in January. "All chicken and duck breast jerky products with a 'Best Before' date of Jan. 29, 2015, and later have been fully tested for and do not contain these antibiotics," the company states in a release.Dogswell also says it does not consider the recalled products to be a health threat to consumers. "It is important to note that this antibiotic is accepted for use in other countries (including the European Union), and there is no evidence that products containing trace amounts of this antibiotic pose a health risk for pets or humans," the release reads.
However, the U.S. Food and Drug Administration (FDA) issued a consumer warning against jerky products imported from China in July 2012. Dogswell sources its protein ingredients from China and manufactures some of its treats there as well. "China is a country where dark meat is more popular due to its inherent fat and flavor," the company states in a "frequently asked questions" section of its website. "Dogswell believes it is less wasteful to obtain our white meat in China where it is abundant, rather than sourcing it domestically, where white meat is less available and held at a premium."
The FDA has been testing chicken and other jerky products since 2007 after reports began mounting concerning imported products. The FDA has not been able to identify a contaminant in the products and therefore has not issued a recall. Currently, FDA continues to urge pet owners to use caution with regard to chicken jerky products.
As for the Dogswell recall, retailers have been instructed to destroy the recalled products in stock. Consumers can call 1-888-559-8833 or email firstname.lastname@example.com with questions or concerns.


text:
Harold Camping Oct. 21 Rapture: Why Do People Listen to Him?
Why do people believe Harold Camping's apocalyptic prophecies? It is a joint effect of a charismatic, convincing personality and a form of internal need to perceive the Bible as a code, Glenn Shuck, Assistant Professor of Religion at Williams College in Williamstown, Mass., told The Christian Post Thursday.
Shuck could not believe that Camping, who promotes his teachings through his Family Radio broadcasts, still had any remaining followers. In 1992, Camping also predicted that the world would end in 1994. Not only that, he even wrote a book, aptly titled, 1994?
"It surprises me that he was able to continue this for this long," Shuck told CP.
However, the scholar, who focuses on new religious movements in the United States, admitted that Camping has a sort of charisma about him that is almost hard to resist.
"I've listened to his radio [broadcasts]. He sounds like a very nice guy. Very calm," he said, adding that the end times preacher definitely manages to, at least superficially, appear believable.
Is that why people believe him?
"I think there's an enduring temptation among Christians to look at the Scripture as a code, despite the warnings," Shuck said.
He added that Christians feel tempted to try to draw a specific time for when Christ will fulfill the promises of bringing His kingdom to earth. It has been a temptation ever since the first generation of Christians, Shuck said. They were actually expecting that Christ would come back during their lifetime.
"This has been going on since the beginning of Christianity," he added. Shuck, author Marks of the Beast: The Left Behind Novels and the Struggle for Evangelical Identity, suggested that, for those who believe Camping, doing some "complicated math" makes it possible to find any answer in the Bible.
Most recently, Camping predicted an apocalypse on May 21, 2011. After no rapture occurred that day, the Bible teacher rescheduled the event for Oct. 21, announcing that the May judgment was only "spiritual." Many who remember the May event feel skeptical about the new prophecy, which will involve a "physical" judgment, according to Camping.
However, according to Shuck, "prophets" like Camping will always have their faithful following. To this day, it is not certain how many people sold their homes, quit their jobs or gave away their life's savings in anticipation of the May 21 rapture.
Among the few people who did share their stories publicly, one thing was for certain – they believed his predictions were the real deal. Undoubtedly, there may still be a few, like Camping himself, who believe Christ will return and the world as we know it will come to an end in only a matter of weeks.


text:
Try the free Travis Strikes Again: No More Heroes chrome extension.
Welcome to the Fun Search Box. We have added the most charming with great quality Travis Strikes Again: No More Heroes wallpapers in 11-02-2018 Do you want to to see Travis Strikes Again: No More Heroes's wallpapers? There are hundreds of wallpapers to see more wallpapers, navigate our website. You will find a lot of wallpapers in funsearchox.com and more! You are able to set your favorite pictures (Family, Games, Movies, Celebrities, etc.) as background! Travis Strikes Again: No More Heroes's some powerful features mentioned below: 1 - Completely different home page for you browser when you set Travis Strikes Again: No More Heroes as your home page. 2 - Date and the weather features. You are able to set more than one location for weather widget! 3 - You will see a new photo of Travis Strikes Again: No More Heroes everytime you refresh the page. 4 - Add notes to your browser and see those notes later! 5 - Reminder feature. You can set a reminder and it will start notice you at the date you have selected. 6 - You can set a favorite photo of Travis Strikes Again: No More Heroes and make it sticky! 7 - Social Media and Shoping links are essentials for you to browse the web faster. 8 - You will have a clean search engine! 9 - You will have customizable widgets. For instance, you will be able to create rss feed widget on your screen. 10 - The games of today section, we will provide you bunch of game list in your browser whatever you want you can play. 11 - You can create a custom background such as family photo or any photo that you like. What are you waiting for? Set your browser's home page to funsearchbox.com right away and have more features.


text:
Consider two d x d complex matrices, R and S, whose entries lie in the unit disk:
$\quad |R_{i,j}|<1 \quad$ and $\quad |S_{i,j}|<1 $.
Say that R is constructed by randomly choosing complex numbers from the unit disk, but S is constructed as
$\quad S_{i,j} = f(i/d,j/d)$
where $f(x,y)$ is a smooth function for $x,y \in [0,1]$, with $|f(x,y)|<1$. In other words, the entries of S are smooth functions of the indices (in the limit of large d), but those of R are not.
How do the trace norms
$\quad ||R||=Tr[\sqrt{R^\dagger R}] \quad$ and $\quad ||S||=Tr[\sqrt{S^\dagger S}]$
of these matrices behave as $d \to \infty$ ?
Numerical Evidence
A few lines of Mathematica strongly suggest that
$\quad ||R|| \propto d^{3/2}$
$\quad ||S|| \propto d$
for large d. (The proportionality constants depend on the probability distribution used to pick numbers from the unit disk for R and the function $f(x,y)$ used to pick entries for S, respectively.)
What explains this behavior?
After Willie's excellent answer below, I thought I'd mention that it's really fast to see the scaling behavior once you discretize the function. Let $F$ be some matrix of discrete values for the function, and let $J_n$ be the $n \times n$ matrix with all elements equal to unity.
$||F \otimes J_n|| = \mathrm{Tr} \sqrt {(F^\dagger \otimes J_n)( F \otimes J_n)} = \mathrm{Tr} \sqrt {(F^\dagger F) \otimes (J_n J_n)} = ||F|| \cdot ||J_n|| = n ||F||$
Basically, the idea is that once the dimension of $F$ is large enough to capture the important detail in the function, increasing the dimension is really just increasing the dimension of $J$.


text:
H.R. Giger, February 5, 1940 – May 12, 2014
"I fight the impending lure of belated sleep
For fear of waking up and you are gone"
Triptykon, My Pain, 2010
For the first time in 74 years, last night was a night not illuminated by the indescribable light that was H.R. Giger.
H.R. Giger became our mentor, against all odds, when we, somewhat audaciously, first established contact with him some 30 years ago. At a time when almost everybody ridiculed, ignored, or even obstructed the music the then almost completely unknown Swiss underground band Hellhammer was creating, Giger listened to us, talked to us, and gave us a chance. Not least at a time when he was at one of many peaks of his path.
A little more than a year later, his exceptionally stunning art made what might be one of Celtic Frost's most important albums, To Mega Therion, even more significant. Other links to Giger's universe also manifested themselves, almost as if it was predestined.
Eventually, after many more years, the mentorship became a friendship. It was a friendship and a personal connection I valued infinitely, and it also included his wonderful wife, Carmen, and many other remarkable people that were part of his universe.
When Celtic Frost came to an end so acrimoniously in 2008, H.R. Giger and his wife were among those who witnessed my uncontained despair and stood by me. That Giger subsequently agreed to collaborate with my new group, Triptykon, and thus enabled us to release our first album, Eparistera Daimones, with one of his most dramatic paintings on the cover meant the world to me.
It apparently pleased Giger, too. He told me so on several occasions, and he completely stunned me in October 2011 by proposing that we continue the collaboration between him and Triptykon. I would have never asked for such a thing, because I never would have wanted to appear insatiable. He brushed such reservations aside, and it was his mentorship, friendship, and art that enabled us, once again, to release a second album on which music and cover art formed a seamless symbiosis. Only a few weeks ago, he held the result in his hands and loved it.
Regardless of anything I may write about H.R. Giger, however, none of these words will ever be able to truly, accurately describe him as a person and as a friend. It is utterly inconceivable to imagine a world without his wit, his perception, his genius, his horizon, his determination, his humour, his friendship, and his immeasurable kindness. And yet, we are now left in exactly such a world.
Tom Gabriel Warrior for Triptykon, May 13, 2014
Triptykon/H.R. Giger Photo Credit: H.R. Giger at his house in Zurich, Switzerland, around the time he created Mordor VII, the painting that would one day become the cover of Triptykon's second album, Melana Chasmata. Photographed by Katharina Vonow in autumn of 1976; used with very kind permission by Katharina Vonow and Carmen Giger.
ZT note: this text is unedited.


text: All Murals Create All Murals Create Back toAll Products Junction Pick your style. White Black From $75/sqm Every mural is made to measure. Customise your size, crop and final price. Design Consultation Whether you need expert advice, want to customise a design or visualise a mural in your space, our design team can help. Contact us International Shipping We ship to most places on earth Easy Install If you have a wall, you're qualified. Read our How To Guide Popular Products Soba Viola Elk Citta Create Your Mural Browse the Store


text:
American Physical Society Sites|APS|Journals|Physics Magazine
- American Physical Society Sites
- Publications
- Meetings & Events
- Programs
- Membership
- Policy & Advocacy
- Careers In Physics
- Newsroom
- About APS
- Become a Member
"For pioneering contributions to the generation of ultra-short wavelength and femtosecond lasers and x-ray laser microscopy."Background:
Szymon Suckewer is Professor of Mechanical & Aerospace Engineering at
In 1985 Suckewer recognized the necessity of using ultrashort pumping pulses of high intensity for the development much shorter wavelengths X-ray lasers. He expanded his group to proceed with the development of an ultrashort pulse KrF laser, which was completed in 1987 and generated intensity of 2 x 1018 W/cm2. This device was used to generate lasing action at 13.5 nm in Li III ions in transition to ground state in 1996.
In 1987 Dr. Suckewer joined the
Presently Prof. Suckewer and his group are developing a powerful femtosecond laser based on Raman amplification and compression in plasma.
Rainer Blatt (Chair), Roberto Merlin (12/06), Marlan O. Scully ('05 Recipient)(12/06), Lou F. DiMauro (V. Chair)(12/07), Paul Lett (12/07)


text:
Have you ever sat back and said to yourself that you'd like a pet, but, in this unstable economy, don't think you'd have the money to support one?
If you answered yes to that question, then Pet Food Stamps is for you!
Pet Food Stamps, is a donation-based program based in New York which aims to supplement the incomes of families below for poverty line with pets so that their furry friends don't go without food and care.
Read more at OpposingViews.com:
[The program] already had more than 45,000 pets sign up in the past two weeks.Marc Okan, the program's founder and director, said it works by having the pet owner's income verified, then they will give the pet food each month from pet food retailer Pet Food Direct for six months. "We're not looking for government funding at this point," Okon said. "Should the government be willing to provide assistance further down the line, we will look into it."As of now, the only way to apply is by filling out an online application. Okan said once they open their new office, they will begin accepting applications through mail.
They are still waiting to be approved as an official nonprofit.
The country does not have a federal pet food stamp program. The U.S. Department of Agriculture Animal and Plant Health Inspection Service does give protection to pets in emergencies and natural disasters. A 1996 Animal Welfare Act, however, does not state anything about giving food to pets.
Though Okon's program seems one-of-a-kind, it's actually one of a few programs in the country that give food to animals in need. Shelters and rescue leagues in the U.S., like the Washington Animal Rescue League, have provided pet food banks for years, in addition to giving discounted pet care.
"One of our missions is to provide income-qualified families with discounted pet care, vaccinations, vaccine clinics, neutered clinics and vet care," Washington Animal Rescue League spokesman Matt Williams said. "We have a new medical center on site. We also have a food bank run entirely on donations."
To be approved for the program, families must provide proof that they are currently receiving government assistance.
Read more about Pet Food Stamps here.
LaTosha Brown Is A Black Joy Blazer Who Has Dedicated Her Life To The Cause
Heart In Your Hands: Important Lifestyle Changes For Heart Failure Recovery
Life In Heart Failure Recovery
How To Support A Loved One Who Is Living With Heart Failure
702 Member Irish Grinstead Dies At 43, Sister Says
Lawsuit Will 'Absolutely' Be Filed After Denny's Waitress Refused Serving Black Truckers In Viral Video: Lawyers
NJ Airport Restaurant That David Brooks Falsely Complained About Is Black-Owned
'African-American Muhammad': Did Marjorie Taylor Greene Make Up A Fake Black Trump Supporter?


text:
Adynxx Enrolls First Patient in Phase 2 Proof-of-Concept Study for AYX1, Lead Compound for the Prevention of Post-Surgical PainFebruary 25, 2013
SAN FRANCISCO, Calif., Feb. 25, 2013 – Adynxx, a clinical-stage pharmaceutical company developing a first-in-class platform of therapeutics to address pain at its molecular roots, announced today that the first patient was dosed in a Phase 2 study of its lead investigational drug candidate for the prevention of post-surgical pain, AYX1.
The 90-patient, placebo-controlled study will evaluate the safety and efficacy of a single administration of AYX1 given prior to unilateral total knee arthroplasty (TKA) to reduce acute pain and to prevent the transition to persistent pain. The study will follow patients for 42 days, with a primary endpoint of pain with walking. Secondary and exploratory endpoints will include pain at rest, pain with knee range of motion, rate and extent of functional recovery, opioid consumption and safety assessments. Further details of the study can be found at www.clinicaltrials.gov.
"While many widely used pain therapies require repeat dosing for symptom amelioration, or require heavy dosing with associated side-effects to treat pain with movement, a single administration of AYX1 has the potential to block the development of pain before it begins," said Donald Manning, M.D., Ph.D., chief medical officer of Adynxx. "This study will evaluate AYX1's ability to reduce acute pain and prevent persistent pain, especially pain associated with movement, enabling patients to begin rehabilitation and resume other activities earlier."
Dennis Podlesak, chairman of the Adynxx board of directors, added, "AYX1 is a novel new treatment option that has the potential to transform how patients suffering from post-surgical pain are treated, and to provide patients and physicians with an innovative and advantageous approach to pain management. The clinical and preclinical results to date are certainly promising, and we look forward to evaluating the efficacy of this potentially breakthrough therapy for the first time in patients. The overall development
plan laid out by the Adynxx team positions AYX1 well to meet the needs of millions of patients who suffer from pain after surgery every year."
Funded exclusively by Domain Associates, Adynxx completed a Phase 1 safety study in healthy volunteers in September 2012 and progressed rapidly to the initiation of its Phase 2 clinical study.
About Adynxx
Adynxx, Inc. is a clinical-stage pharmaceutical company developing a transformative technology platform addressing pain at its molecular roots, which potentially prevents the development of pain following surgery or trauma and resolves established chronic pain syndromes. Adynxx's unique approach is to transform pain management by addressing pain as a disease rather than a symptom.
Adynxx's lead compound, AYX1, is an investigational drug designed to reduce acute post-surgical pain and prevent the transition to persistent or chronic pain with a single administration at the time of surgery. A Phase 2 study evaluating a single dose of AYX1 prior to unilateral total knee arthroplasty is ongoing. Additional therapeutic candidates in the AYX platform which are intended to resolve multiple forms of chronic lower back pain, intractable neuropathic and inflammatory pain syndromes are currently under active preclinical development.


text:
Do you need some motivation?
Are you struggling with bad habits, managing finances, or fitness goals? Do you have big dreams, but lack the willpower to get up and go? Do you want to improve your life situation, become healthier, or start a successful business?
If so, these top motivational podcasts can help.
In this article, we share 11 of the best motivational podcasts on business, personal development, health and fitness, and money.
Although these podcasts can't change your life for you, they can inspire, teach, and motivate you to go after the life you want.
Let's jump in.
Post Contents
- The Best Motivational Podcasts on Business
- The Best Motivational Podcasts for Personal Growth
- The Best Motivational Podcasts About Money
- The Best Motivational Podcasts on Health and Fitness
- Summary: The Best Motivational Podcasts to Listen to in 2021
- Want to Learn More?
Start selling online now with ShopifyStart your free trial
The Best Motivational Podcasts on Business
Do you want to grow your income, create more financial freedom, or pursue your passion? These business motivational podcasts can help you start a business and build the life of your dreams.
Motivational Podcast #1. Shopify Masters
Perfect for: Those looking to start an online business with very little money.
Shopify Masters one of the best motivational podcasts for new entrepreneurs. It covers all things ecommerce, dropshipping, and how to start an online business.
Shopify's team interviews successful entrepreneurs who have started their own ecommerce businesses. These guests share their personal stories, top tips, and answer listener's questions.
Unlike many business podcasts, the entrepreneurs featured are relatable, everyday people who have worked hard to achieve success. So, if you're looking for motivation to start, manage, or scale an online business, this podcast is for you.
Best motivational podcast episodes:
- How This Couple Created an $800k Business While Working Full-Time
- Starting a Business Instead of Going to College
- Tomas Slimas on How Failure Led to The World's Most Popular Dropshipping App
Listen on:
Motivational Podcast #2. The GaryVee Audio Experience
Perfect for: Kickstarting your motivation to grind, hustle, and succeed.
The GaryVee Audio Experience is a high-energy, hard-hitting motivational podcast featuring a variety of content from entrepreneur Gary Vaynerchuk.
Vaynerchuk is known for his social media marketing agency VaynerMedia. So, it's no surprise that he's very active on social media and publishes tons of content every day.
The podcast is bursting with business and marketing tips, tactics, and advice. Vaynerchuk also shares his views on creating a life and mindset geared towards success.
New episodes are published daily, and they can last anywhere between 3 minutes and 2 hours.
Best motivational podcast episodes:
- Get Motivated By Working On Your Passion
- It's Ok To Feel Lost
- Stop Blaming Others & Take Full Responsibility
Listen on:
Motivational Podcast #3. Entrepreneurs On Fire
Perfect for: Learning how top entrepreneurs think and act to achieve success.
Entrepreneurs On Fire is one of the best motivational podcasts covering business, marketing, and entrepreneurial mindset.
In each episode, host John Lee Dumas interviews highly successful entrepreneurs. These guests share actionable tactics and strategies to help you build the business and life of your dreams.
New episodes are published every 2-5 days and are typically 25-30 minutes long. Plus, the show has more than 2,500 episodes, so you'll never run out of motivational material.
Best motivational podcast episodes:
- How to Keep Your Motivation Strong, Your Vibe High, and Your Quest for Transformation Unstoppable with Jen Sincero
- Q&A: What metrics to focus on and how to stay motivated; JLD answers YOUR questions LIVE!
- 7 Months to 7 Figures with Tony Delgado
Listen on:
The Best Motivational Podcasts for Personal Growth
Working to become a better person takes time, dedication, and perseverance. If you're working to become your best self, here are three of the best motivational podcasts to help.
Motivational Podcast #4. The School of Greatness
Perfect for: Gaining motivation and inspiration from ultra-successful individuals.
The School of Greatness is hosted by Lewis Howes, a New York Times best-selling author, All-American athlete, and entrepreneur.
Howes interviews some of the most successful people on the planet in business, sports, entertainment, science, and more. Past guests include author Dan Harris, entrepreneur Gary Vaynerchuk, and actor and comedian Kevin Hart.
Each episode features stories, techniques, and tips that will motivate and inspire you to grow and lead a better life. Topics include overcoming fear, managing relationships, love, success, business, and more.
Howes releases new episodes every 2-3 days, and they're between 6 minutes and 1.5 hours long.
Best motivational podcast episodes:
Listen on:
Motivational Podcast #5. The Mindvalley Podcast
Perfect for: Expanding your mind and stepping into your potential.
The Mindvalley Podcast is all about the nitty-gritty aspects of personal growth.
This top motivational podcast can help you to break free of limiting beliefs and step into your power. It's packed full of actionable strategies and tactics to improve your mindset, beliefs, and performance.
The founder of personal growth education company Mindvalley, Vishen Lakhiani, hosts the podcast. Episodes feature experts and teachers in various fields, such as psychology, science, business, and spirituality.
New episodes are released every 2-7 days and are typically between 30 minutes and 1 hour long.
Best motivational podcast episodes:
- 9 Steps to Unlock The Millionaire Within You with Regan Hillyer
- How To Achieve The Life Of Your Dreams with Jon and Missy Butcher
- How to Find Out What You Actually Want in Life
Listen on:
Motivational Podcast #6. Optimal Living Daily
Perfect for: Small doses of motivation and inspiration while on-the-go.
Do you bookmark interesting articles online, but never get around to reading them? Optimal Living Daily can help.
This free motivational podcast features some of the best articles online. Every day, a handpicked article will be read by the hosts. Many of these articles are written by notable experts and authors.
The episodes feature a range of topics, such as business, mindfulness, personal growth, and minimalism.
Plus, episodes are between 6-10 minutes long, so you can get a daily dose of motivation and inspiration on-the-go.
Best motivational podcast episodes:
- The New Currency: The Importance of Time Over Money by Andrew James of Establishing The Self
- Three Mistakes. The Path to Success by James Altucher on How To Lead A Successful Life & Personal Growth
- Tips to Attract What You Want in Life with the Law of Attraction by Ellen Burgan of If It Brings You Joy
Listen on:
Motivational Podcast #7. The Happier Podcast
Perfect for: Improving your habits and perceptions to help you create the life you want.
Our habits, perceptions, and relationships all contribute to our level of happiness and ability to remain motivated.
The Happier Podcast is a personal, lively, and thought-provoking motivational podcast hosted by best-selling author Gretchen Rubin.
This podcast features practical tips and advice on how to improve the quality of your life. Episodes can help you to improve your outlook, experience more joy, and – as a result – stay motivated. Topics range from productivity and friendships to creativity and love.
New episodes are shared every 1-7 days and can be anywhere between 2 and 50 minutes long.
Best motivational podcast episodes:
- Little Happier: A Different, Happy Way to Think About Exerting Our Willpower (a Task that Doesn't Usually Sound Appealing)
- Little Happier: Habits Are the Invisible Architecture of Everyday Life
- Why We Should Deal with Something Negative Right Away
Listen on:
The Best Motivational Podcasts About Money
Need some motivation to save money, pay down debt, or start investing? Want to learn how to manage your finances more effectively? These free motivational podcasts can help you achieve financial freedom and prosperity.
Motivational Podcast #8. The Dave Ramsey Show
Perfect for: Motivating you to take control of your money.
The Dave Ramsey Show is a good motivational podcast for anyone with money troubles. It's hosted by Dave Ramsey, a personal finance expert and best-selling author of seven books.
Ramsey's mission is to motivate and empower listeners to get out of debt and create financial abundance. He doesn't beat around the bush and always cuts straight to the heart of any financial problem.
Listen to this motivational podcast for tips on budgeting, managing debt, investing, accounting, and insurance.
A new show is published every day. The show runs for three hours and is broken down into one-hour episodes.
Best motivational podcast episodes:
- I Struggle With Confidently Pricing My Services
- These Baby Steps Will Give You Economic Immunity
- The More Money You Have, the More Good You Can Do
Listen on:
Motivational Podcast #9. So Money
Perfect for: Learning how to manage your money to create financial abundance.
So Money is one of the best motivational podcasts on money. Award-winning finance strategist Farnoosh Torabi hosts the show.
It features Q&A's with Torabi and interviews with successful people in a variety of industries. Guests share their personal finance stories, the mistakes they've made, and their strategies to manage their money effectively.
Episodes cover topics such as the basics of money management, investing strategies, paying off credit card debt, and more.
New episodes are posted every 2-3 days and typically last 25-50 minutes.
Best motivational podcast episodes:
- How to Live on the Smallest Budget with Jully-Alma Taveras, Founder of Investing Latina
- Owning Your Financial Edge with Harvard Professor Laura Huang
- Fighting Limiting Money Beliefs (Especially Now) with Erika Gerdes
Listen on:
The Best Motivational Podcasts on Health and Fitness
Maintaining a healthy diet and a regular exercise regimen can demand a lot of effort and dedication. These top motivational podcasts are bursting with information, advice, and inspiration to help you achieve your health and fitness goals.
Motivational Podcast #10. Hurdle
Perfect for: Finding the motivation to overcome obstacles in life.
Hurdle is a motivational podcast focused on health and well-being.
In each episode, host Emily Abbate sits down with inspiring individuals who have used wellness habits to overcome tough times and achieve big wins.
You can expect motivational insights and candid discussions from entrepreneurs, magazine editors, professional athletes, and more. The show covers topics such as meditation, running, cycling, and weight-loss.
New episodes are shared on Mondays, Wednesdays, and Fridays. Episodes last between 10 minutes and 1.5 hours.
Best motivational podcast episodes:
- #HURDLEMOMENT: How to Stop Making Excuses & Go After What You Want
- 5-MINUTE FRIDAY: Are You The Only Thing Holding Yourself Back?
- SPECIAL EPISODE: 4 Female Powerhouses Share How To Find Your ROAR
Listen on:
Motivational Podcast #11. Nutrition Matters
Perfect for: Learning how to maintain a healthy diet and a positive relationship with food.
Nutrition Matters is one of the best motivational podcasts about food. It offers plenty of actionable takeaways that you can use to improve your diet and relationship with food.
It's hosted by the registered dietician and nutritionist Paige Smathers, who interviews a variety of health and wellness experts. Plus, you can listen to real-life stories from people who have overcome eating disorders, difficulties with weight, and other food issues.
This motivational podcast shares just two new episodes per month – but there are more than 175 episodes for you to benefit from. Episodes typically last between 45 minutes and 1 hour 15 minutes.
Best motivational podcast episodes:
- A Simple, Straightforward Way to Decide What To Eat
- Hitting Diet Rock Bottom
- What Does it Look Like When Things are Going Well with Nutrition and Body Image?
Listen on:
Summary: The Best Motivational Podcasts to Listen to in 2021
Motivational podcasts can help empower you to create the life you want. In summary, here's a list the 11 best motivational podcasts to listen to in 2021:
- Shopify Masters
- Entrepreneurs On Fire
- The GaryVee Audio Experience
- The School of Greatness
- Mindvalley Podcast
- Optimal Living Daily
- The Dave Ramsey Show
- So Money
- Hurdle
- Nutrition Matters
- The Happier Podcast
Have we missed any of the best motivational podcasts out there? Share your favorites in the comments below!
Start selling online now with ShopifyStart your free trial


text:
9.7Removing a Contact
We would like to display an anchor which, when clicked, removes an item from this list. For this we just can redefine
renderContact:on: as follows. We add another callback with the 'remove' text, see Figure 72.
ContactListView>>renderContact: aContact on: html
html text: aContact name , ' ' , aContact emailAddress.
html text: ' ('.
html anchor
callback: [ self removeContact: aContact ];
with: 'remove'.
html text: ')'
ContactListView>>removeContact: aContact
Contact removeContact: aContact
Try it yourself. Click on the remove anchors. The corresponding contact entry will be removed from the database. When you're done playing around be sure to reset the database as described at the end of Section 9.4.
It would be nice to get a confirmation before removing the item. The following method definition fixes that.
ContactListView>>removeContact: aContact
(self confirm: 'Are you sure that you want to remove this contact?')
ifTrue: [ Contact removeContact: aContact ]
We send the component (self) the message
WAComponent>>confirm:, which displays a "Yes/No" confirmation dialog (See Figure 73).
The method
confirm: returns
true if the user answers "Yes" and
false otherwise. This is very straightforward because Seaside handles all the complexity for you, which is amazing when you consider what a mess this kind of interaction is with many other web frameworks. Let's look at what happens:
- The user clicks on the anchor, causing the web browser to submit a request to Seaside.
- Seaside finds and evaluates the callback for the anchor (our block of code).
- The callback sends
ContactListView>>removeContact:, which in turn sends
- The execution of
ContactListView>>removeContactis suspended, and the confirmation page is returned to the user's web browser.
- The user clicks the "Yes" or "No" button causing their browser to send a request to Seaside.
- The confirmation component handles this request, "answering"
trueif the user clicked "Yes" and
- When the confirmation component answers, the
ContactListView>>removeContact:method resumes execution and processes the answer from
confirm:, deleting the contact item if the answer was
So, in Seaside, it is easy for a method to display another component, wait for the user to interact with it, and then resume execution when that component has completed its job. This is akin to modal dialogs in Graphical User Interface (GUI) applications, see Part III.


text: Play Summary The Wars of the Roses (1455-1485) being over, Richard of Gloucester determines to gain the throne occupied by his brother, Edward IV. He first manages to turn Edward against the Duke of Clarence, who is imprisoned in the Tower on the charge of treason. Next, he wins the hand of Lady Anne, even as she follows the hearse bearing the body of the murdered Henry VI. As part of his plan, Richard succeeds in convincing Hastings and Buckingham that the queen and her faction are to blame for Clarence's imprisonment. Hired murderers carry out his instructions to put Clarence to death. Richard joins the other members of the hostile factions in solemnly vowing in the presence of the dying Edward to hold the peace. The remorseful king learns that Clarence has been put to death before he himself dies. When the young Prince Edward is sent for from Ludlow to be crowned, Richard moves quickly to meet this turn of events. Buckingham, now Richard's "second self," promises to separate the prince from the queen's kindred. Lord Rivers, Lord Grey, and Sir Thomas Vaughan are imprisoned by Richard and are executed. The frightened queen seeks sanctuary for her son. With a great display of courtesy and devotion, Richard has Prince Edward and his brother lodged in the Tower. Finding that Hastings remains loyal to the prince, the villain-hero denounces him as a traitor and orders his execution. Soon thereafter, Rivers, Grey, and Vaughan meet like fates. Next, Richard convinces the Lord Mayor of London that he has acted only for the security of the realm. He has Buckingham slander the dead Edward, implying that the late king's children are illegitimate and that Edward himself was basely born. When citizens of London, headed by the lord mayor, offer him the crown, Richard accepts it with pretended reluctance. Arrangements are made for his coronation. The despairing queen-mother fails in an attempt to visit her sons in the Tower just before Richard is crowned. To secure his position, the new king suggests to Buckingham that the young princes be put to death. But the duke falters at the thought of such a monstrous deed. Dorset, it is learned, has fled to Britanny to join Henry, Earl of Richmond. This turn of events does not deter King Richard. He has rumors spread that his wife is mortally ill; he arranges a lowly match for Margaret, Clarence's daughter; he imprisons Clarence's son; he engages Sir James Tyrrel to undertake the murder of the little princes. Buckingham, now treated disdainfully and denied the promised earldom of Hereford, resolves to join Richmond. Anne dies, and Richard offers himself as husband for his niece, Elizabeth of York. Richmond lands at Milford at the head of a mighty army. Joined by many nobles, he marches inland to claim the throne. Buckingham is captured and slain. The two armies meet at Bosworth Field, and the two leaders are encamped on either side. That night, the ghosts of Richard's victims appear, indicting him and prophesying his defeat. In contrast, Richmond has "fairboding dreams" and is assured that "God and good angels" stand ready to assist him. Both Richard and Richmond address their troops before the battle begins. Richard fights courageously but is overcome and slain in personal combat with Richmond, who accepts the crown and proposes to marry Elizabeth of York, thus ending the dissension between the two great factions.


text:
Yesterday the world saw a Range Rover driver run over a number of motorcyclists, sparking a massive chase through NYC that ended in the SUV driver getting beaten in front of his family. Now the police have arrested the motorcycle rider at the very start of the incident.
28-year-old Christopher Cruz can be seen in the video (and in the screenshot above) in a white t-shirt slowing down in the middle lane of the West Side Highway, right in front of the now-famous black Range Rover driven by 33-year-old Alexian Lien with his wife and two-year-old in the car. Cruz got hit by the Range Rover for this brake check and was later hospitalized and released for minor injuries, reports the New York Post.
The police have since arrested Cruz and thrown the book at him, effectively marking him responsible for the half-hour chase that ended with Alexian Lien beaten and his car smashed. Police charged Cruz with reckless endangerment, reckless driving, endangering the welfare of a child, and menacing, reports the New York Post.
What's worst about this whole incident is that much of it seems to stem from a number of misunderstandings. According to motorcyclist Rene Towles present during the ride and later interviewed by the New York Times, the bikers who surrounded Lien's Range Rover after Lien rear-ended Cruz didn't intend to be violent at all.
"No biker became aggressive with the driver after the incident," said Mr. Towles, who belongs to a Brooklyn motorcycle club. "People were just trying to find out what just happened."
This quote specifically refers to when Lien first hit Cruz, not later stops that ended with Lien getting beaten.
It's also in this first stop when Lien takes off for the first time, which is when one rider got his legs broken, according to earlier police reports. One Facebook group titled "Justice for Jay Meezee," however, claims that the rider was named Jeremiah Mieses (pictured below in the purple shirt on the green motorcycle), and that his injuries extend far beyond broken legs.
Broken Spine, Broken Ribs, Crushed Lungs, Busted Aorta and the list is endless! Currently in a Coma and Paralyzed from the waist down!!
Justice for Jay Meezee also posted the following two pictures of Mieses in the hospital.
UPDATE: Another rider has turned himself in to the police, as Gawker notes. The unidentified rider had been seen punching the rear window of the Range Rover at the end of the video, just as another rider smashes in a front window with his helmet. The 42-year-old was wanted by the police, reports NBC 4.
(Hat tip to williamforte and McMike)
Photo Credit: LiveLeak


text:
If you are looking for a good-condition second-hand tractor in Eluru Andhra Pradesh, then Tractorkarvan is the right place for you. There are 3 used tractors from Eluru Andhra Pradesh listed on Tractorkarvan. All these second-hand tractors top brands are available within your budget and at the best possible price. The starting price of a used tractor in Eluru Andhra Pradesh is only INR 200,000.
Buy any good condition second-hand tractor from Andhra Pradesh's top districts on Tractorkarvan. We have listed all the second-hand tractors available for sale in Eluru Andhra Pradesh. These old tractors are available at the current market price and with all the specifications and features.
We have listed 3 second-hand tractors in Eluru Andhra Pradesh along with their pictures. We have also provided the names of verified sellers/ dealers.
The old tractor price in Eluru Andhra Pradesh ranges between 200,000 and 500,000. Buy an affordable used tractor for you in Eluru Andhra Pradesh.
Disclaimer: Second-hand tractors Buy and Sell is a Peer-to-Peer information service. Tractorkarvan provides a digital platform to enable and support farmers and owners to buy / sell used second-hand tractors. Tractorkarvan makes all reasonable efforts to ensure that all information on second-hand tractors is accurate but is not responsible for information provided by Sellers/Dealers. Buyers should verify tractor condition, documents, and other information physically before making payment. Prices shown on Tractorkarvan are provided by sellers and does not include transportation, yard charges, document charges etc.
Call Us At+91-9650-9338-99


text:
I have been foul all week. The worst mood ever. Mostly due to a lingering cold/maybe sinus infection. But also because of detox. No more holiday drinking, no more farting around eating Oreos all day. It's a chicken-only existence right now. I hate chicken so much. But the tv work is starting up again, we're heading to Sundance soon, and then in 7 weeks it's the Oscars, which means, literally, eating will not be fun until February 28. Instead, I'll be busting it at the gym, and in the pouring rain, and dreaming about burgers and fries, pasta, mashed potatoes, dimsum, and peking duck.
Thanks God for Ryan Gosling.
He was on Ellen today. He was funny and cute and smart and articulate and engaging and really silly and very, very natural and perfect. See how quick he is? It's because he's present in the conversation. Because he's not up his own ass with self-consciousness. You get a lot of these actor/actress twats, they're all awkward and weird, and it's because they're too busy being inside their own heads, thinking about themselves, overanalysing their own "shyness".
Ryan delivered a talk show clinic. Also, he looks really great in a onesie and I love when he talks about his mother.


text:
Manduka Pro Legging High Rise 7/8 With Pocket - Black
Designer: Manduka
One of our most versatile leggings, the Presence Legging is a stylish high-rise fit with just the right amount of compression. Sporting two side pockets, this comfy and supportive bottom transitions perfectly from studio to street.
- Cropped legging with high-rise fit
- Waistband is made from powermesh to hold you in while allowing you to move
- No dig inseams allow for all-day wear
- Ultra-flattering cropped leg for any setting
- External side pockets at thigh
- Highly breathable and fast drying fabric
- Sustainably Made: Uses materials that are betterfor our planet and your practice
- 25 inseam (63.5 cm)
- PRO Knit Fabric: 77% Nylon, 23% Spandex


text:
SILVER SPRING, Md. -- An FDA advisory committee voted unanimously, 14-0, on Wednesday against approval of inhaled mannitol (Bronchitol) for cystic fibrosis (CF), citing safety and efficacy concerns, particularly in pediatric patients.
Panelists on the Pulmonary-Allergy Drugs Advisory Committee were troubled by a lack of statistical evidence of efficacy from two trials and by an increased risk of hemoptysis in children.
"I wish I could vote yes because I think there is a place for a drug like this, but further studies are necessary," panelist Mary Cataletto, MD, of Winthrop University Hospital in Mineola, N.Y., said during the meeting.
In separate votes on efficacy and safety, panelists came down against both 11-3. With regard to efficacy, committee members expressed concern about the fact that the first study, although it showed a significant effect, was plagued by missing data, and a second study with full data turned up a nonsignificant effect on FEV1.
Some panelists said the data appeared to show that the drug may have significant effects in adults but not in children, arguing that they would support an indication for CF patients ages 18 and up.
There were also questions about whether the drug might have benefits in a specific subpopulation, which hasn't yet been investigated.
"There's no doubt in my mind that a subset of individuals would benefit greatly; we just don't know who they are," panelist James Tracy, DO, of Creighton University in Omaha, said.
Chief among the safety concerns were an increased risk of hemoptysis in children and high dropout rates in both studies.
Panelist Paul Greenberger, MD, of Northwestern University in Chicago, noted that the wrong dose may have been used in these studies, as earlier dose-response trials may have given misleading results.
"They may have led to too high of a dose," he said. "You may get more benefit with a dose lower than 400 mg [twice daily]."
Australian drugmaker Pharmaxis was seeking an indication for improved pulmonary function for CF patients ages 6 and up.
The company had conducted two 26-week trials in 600 patients. One met its primary endpoint of increasing FEV1 by an average of 83 mL by the end of the trial compared with placebo (P<0.001). The second trial resulted in a mean FEV1 increase of 54 mL, which wasn't significant (P=0.059).
Both studies also had high dropout rates, with 34% of 177 drug-treated patients dropping out of one of the studies, compared with 23% of controls. In the second trial, 85% of 184 drug-treated patients finished the 6-month trial compared with 92% of controls.
Mannitol bears little resemblance to ivacaftor (Kalydeco), the most recent drug approved for CF. That drug targets an underlying cause of the disease -- abnormal chloride trafficking -- in a subset of CF patients (4% to 5%) who have the G551D-CFTR mutation.
Most CF drugs only work to alleviate symptoms and treat complications rather than on the disease itself.


text:
Discrete impurity effects in terms of their statistical variations in number and position in the inversion and depletion region of a MOSFET, as the gate length is aggressively scaled, have recently been researched as a major cause of reliability degradation observed in intra-die and die-to-die threshold voltage variation on the same chip resulting in significant variation in saturation drive (on) current and transconductance degradation—two key metrics for benchmark performance of digital and analog integrated circuits. In the following chapter, the authors have highlighted the random dopant fluctuation (RDF) based Ensemble Monte Carlo(EMC)device simulation study conducted by the Computational Electronics (COMPUTEL) research group of Arizona State University. In addition to RDF, random number and position of interface traps lying close to Si:SiO2 interface engender additional concerns leading to enhanced experimentally observed fluctuations in drain current and threshold voltage. In this context, the authors of this chapter present novel EMC based simulation studies on trap induced random telegraph noise (RTN) responsible for statistical fluctuation pattern observed in threshold voltage, its standard deviation and drive current in saturation for 45 nm gate length MOSFET device. From the observed simulation results and their analysis, it can be cogently projected that with continued scaling in gate length and width, RTN effect will eventually supersedeas a major reliability bottleneck over the typical RDF phenomenon. The fluctuation patterns observed by EMC simulation outcomes for both drain current and threshold voltage have been analyzed and explained from analytical device physics perspectives.
|Original language
|English (US)
|Title of host publication
|Circuit Design for Reliability
|Springer New York
|Number of pages
|ISBN (Print)
|9781461440789, 9781461440772
|Published - Jan 1 2015
ASJC Scopus subject areas
- Engineering(all)


text:
Development environments
Instead of just using compiler + editor, you can use complete image create "development tool chains" which integrate compiler, build system, packaging tools etc. in one tool chain.
Ubuntu is currently listed as the default distribution on the Raspberry Pi website, but they have now stated they will not be supporting the ARMv6 architecture, so Ubuntu is likely to be dropped.
Eben says (regarding default distribution): "Either Ubuntu or Fedora; the main point in Fedora's favour is their ongoing support for ARMv6 architectures."
Eben says (regarding default distribution): "Either Ubuntu or Fedora; the main point in Fedora's favour is their ongoing support for ARMv6 architectures."
As of October 15 2011: the Raspberry Pi alpha board boots Fedora F13 (armv5tel) to a character-mode login prompt in about 23 seconds, taking 14-17MB of memory. XFCE and LXDE graphical environments are both available (but more work on the X drivers is needed). F15-ARM will be tested as its release date approaches in November. A 1-minute video is available at [1]. Video about Seneca College and Fedora on Raspberry Pi: [2]
ShiftPlusOne has documented the work needed to get a QEmu environment up and running: http://raspi.springnote.com/
A more detailed tutorial by emercer, based on the above: http://cronicasredux.blogspot.com/2011/09/installing-and-running-debian-armel-on.html
- http://www.raspberrypi.org/forum/?mingleforumaction=viewtopic&t=261
- http://www.raspberrypi.org/forum/?mingleforumaction=viewtopic&t=577
Gentoo Linux is a computer operating system built on top of the Linux kernel and based on the Portage package management system. It is distributed as free and open source software. Unlike a conventional software distribution, the user compiles the source code locally according to their chosen configuration. There are normally no precompiled binaries for software although for convenience some software packages (such as Mozilla Firefox and LibreOffice) are also available as precompiled binaries for various architectures where compiling would otherwise be very time consuming.
Discuss: http://www.raspberrypi.org/forum/?mingleforumaction=viewtopic&t=462
KidsRuby is what it sounds like – a Ruby for kids – and it's running beautifully on the Raspberry Pi. This is exactly the sort of application we want to see on the device, and we're really pleased to see it up and running. It looks like there will be some optimisation for speed before we launch, but what's there already is very useable.
R.Pi blog entry: http://www.raspberrypi.org/2011/09/kidsruby-on-raspberry-pi-another-video-demo/ More info & Video: http://confreaks.net/videos/637-gogaruco2011-kidsruby-think-of-the-children?player=html5
Meego & XBMC
The MeeGo project provides a Linux-based, open source software platform for the next generation of computing devices. The MeeGo software platform is designed to give developers the broadest range of device segments to target for their applications, including netbooks, handheld computing and communications devices, in-vehicle infotainment devices, smart TVs, tablets and more – all using a uniform set of APIs based on Qt. XBMC is an award-winning free and open source (GPL) software media player and entertainment hub for digital media. Meego TV 1.2 uses XBMC as a reference GUI (that is, a starting point for creating a custom GUI).
- http://www.madeo.co.uk/?p=783
- http://www.madeo.co.uk/?page_id=605
- http://wiki.meego.com/User:Vgrade#Raspberry_Pi
Discuss: http://www.raspberrypi.org/forum/?mingleforumaction=viewtopic&t=144
Debian ARM
Debian was the default distribution on the Alpha boards. Boot time depends on width & speed of SD-card. Alpha board boot into Debian prompt (no GUI) was timed taking about 34 seconds.
RISC OS is a fast and lightweight computer operating system designed in Cambridge, England by Acorn. First released in 1987, its origins can be traced back to the original team that developed the ARM microprocessor. RISC OS includes BBC BASIC which was primarily conceived to teach programming skills as part of the BBC computer literacy project.
- RISC OS Open (ROOL) has released the sources. Community members have ported the OS to the BeagleBoard and similar hardware
- In November 2011, RISCOScode.com announced that RISC OS will be available as an alternative OS for Raspberry Pi from launch
- RaspberryPi forum thread
- ROOL forum thread
RISC iX
RISC iX was a project Acorn Computers undertook after releasing the first edition of Arthur OS. The project goal was to build a replacement to Arthur which was to based on a UNIX (4.3BSD) distribution. Featuring a Mach kernel, X11 display interface and the standard UNIX userland tools compiled for the ARM architecture, this operating system was never fully embraced by Acorn due to development delays. Subsequently RISC OS was hastily developed and delivered as the standard OS to supercede Arthur. However RISC iX was completed and is officially available at the Acorn historical archive and various other hobbyist websites. It should be perfectly possible to run RISC iX on the Raspberry Pi (RISC PiX?)
- http://en.wikipedia.org/wiki/RISC_iX
- http://acorn.chriswhy.co.uk/Riscix.html
- http://acorn.chriswhy.co.uk/RISCiXComputers.html
- http://www.jfc.org.uk/documents/riscix_clone.html
- http://acorn.riscos.com/riscix/
GeeXboX ARM
GeeXboX is a free and Open Source Media-Center purposed Linux distribution for embedded devices and desktop computers. GeeXboX is not an application, it's a full-featured OS, that one can boot as a LiveCD, from a USB key, an SD/MMC card or install on its regular HDD. The GeeXboX distribution is lightweight and designed for one single goal: embed all major multimedia applications as to turn your computer into an HTPC.
Scratchbox is a cross-compilation toolkit designed to make embedded Linux application development easier. It also provides a full set of tools to integrate and cross-compile an entire Linux distribution. To find out what it can do, take a look at some of the documentation.
There is now an Oracle Virtualbox VM image with a scratchbox2 install inside.
More details and discuss: http://www.raspberrypi.org/forum/?mingleforumaction=viewtopic&t=454
OpenEmbedded is a build framework and cross-compile environment for embedded Linux.