text:
"Pembrolizumab + Poly-ICLC in MRP Colon Cancer"
(That is: Pembrolizumab (Keytruda) + Poly-ICLC (Hiltonol; experimental viral mimic and broad activator of innate immunity) in MRP ( = MSS) Colon Cancer"
Not yet recruiting. Only at Georgia Cancer Center, at Augusta University
"Current clinical trials are showing that patients whose tumors are mismatch repair deficient (MSI) are more likely to respond to immune-boosting anti-PD-1 drugs—such as pembrolizumab—than those with tumors proficient in mismatch repair (MRP or MSS). The idea is that the greater the number of DNA glitches in a tumor cell, the more abnormal proteins it will produce—and the more abnormal proteins that are generated, the greater the odds that the body's immune cells will regard the tumor cells as "foreign" and target them for destruction. Thus far, PD-1 inhibitors have shown great promise for mismatch repair deficient cancer patients, but not for mismatch repair proficient (MRP) cancer patients.
In this clinical trial, the investigators hypothesize that treating MRP colon cancer patients with immunostimulating agent poly-ICLC will generate an inflammatory response, increasing epitope recognition and development of tumor reactive T-cells at the tumor site. However, interferon alpha and gamma produced by the poly-ICLC will increase PD-L1 expression and limit new T-cell development. Thus, PD1 blockade will increase the effectiveness of treatment with pembrolizumab."
Description of Poly-ICLC: http://adisinsight.springer.com/drugs/800001705
Activating the Natural Host Defense
Hiltonol (Poly-ICLC) : http://www.oncovir.com/id2.html


text:
Arizona Municipal Lawyers
Find Arizona Municipal Attorneys by City
Michael N Widener
(800) 847-9094
University of ArizonaUniversity of Illinois - Urbana-Champaign and University of VirginiaArizona and TennesseeArizona Town Hall and Maricopa County Justice Museum & Learning CenterLocal Regulation of Drones in Lower Airspace and Tactical Urbanism V2
Francis (Buzz) Slavin
(602) 381-8700
U OF CINCINNATIArizonaArizona State Barhttps://www.fjslegal.com/blog/2021/01/overview-of-arizonas-mechanics-lien-laws/ and Arizona Construction Law and Mechanics Liens
James D. Griffith
(800) 514-6064
Phoenix School of LawWestern Illinois UniversityArizona, U.S. District Court-Arizona, Hopi Tribal Courts and Navajo NationNavajo Nation Bar Association and Coconico County Bar AssociationTribal Jurisdictions and the Unauthorized Practice of Law and The Model Tribal Secured Transactions Act: Self-Determination and Tribal Economic Development
Carl R Sammartino
(520) 623-5466
University of ArizonaUniversity of Michigan - Ann ArborArizona Bar Association and Pima County Bar
David P Gordon
(928) 649-8609
WESTERN NEW ENGLANDArizonaArizona State Bar
Steven Russo
(520) 529-1515
James E. Rogers College of Law, University of ArizonaUniversity of ArizonaArizonaCommunity Development Block Grant Award, The Wellness Council of Arizona and The Willie Kane AwardArizona Bar Association, Arizona Society of Certified Public Accountants...
Mandi Jean Karvis
(602) 532-5816
Southern Illinois University - CarbondaleQuincy UniversityArizonaArizona State Bar and Macicopa County Bar Association
Andrew Moore
(480) 699-7454
ASUArizonaArizona State Bar
Julie Rhodes
(602) 266-9552
U OF WIArizonaArizona State Bar
The LII Lawyer Directory contains lawyers who have claimed their profiles and are actively seeking clients. Find more Arizona Municipal Lawyers in the Justia Legal Services and Lawyers Directory which includes profiles of more than one million lawyers licensed to practice in the United States, in addition to profiles of legal aid, pro bono and legal service organizations.
Researching Attorney Discipline

subset: commoncrawl


text:
Free Montana CDL General Knowledge Practice Test 2023
You are looking for actual practice for your coming CDL test? So you have come to the right place. Our MT General Knowledge Practice Test has the same questions as the real exam which is based on the Montana CDL Manual. Our CDL practice test pack covers most of the subject areas on the Montana General Knowledge Test such as shifting techniques, railroad crossing safety, drunk driving laws, and much more to make you become a safer driver. In addition, each question has a detailed explanation that will help you understand the concept and answer future questions about it correctly. If you don't get the pass right away, don't worry, you can take this practice test an unlimited number of times to make sure you learn all the questions. Our Montana CDL Practice Test will refine your driving knowledge so you can earn your CDL and start driving on the roads. Let's take our practice test now!


text:
Bizzabo 4+
Bizzabo Ltd.
Designed for iPad
- Free
Bizzabo's universal event app is trusted by leading brands across the world who believe in the power of events to bring people together. With Bizzabo, event experiences are more impactful and rewarding. Winner of the "People's Choice Award for Best Event Technology Provider" for 3 years in a row.
With the Bizzabo app you can:
Review the event agenda, view session locations or find out anything that you need to know about your event
See who else is attending your event and view their profiles
Message other attendees with private one-on-one messages
Stay in the know with real-time updates about sessions, speakers and special offers
Participate in live polls and surveys administered by presenters
Share event updates directly to social media
"After demoing Bizzabo I can confidently say it's one of the best conference apps I've seen, and I've seen a few." – TechCrunch
Review the event agenda, find session locations, read up on speaker bios, see who else is attending your event, participate in polls and more—all from the palm of your hand.
Make the most of your event with private one-on-one messaging, robust attendee profiles, and social media integrations.
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For more information, visit Bizzabo.com.
What's New
Version 6.6.130
• UI improvements
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Ratings and Reviews
Positive attendee experience
Very easy to view the agenda and see where I am supposed to go next at an event, especially with a large footprint. I also like being able to save sessions to my own "agenda" vs. having to scroll through the whole agenda every time. Overall just a simple, straight forward event app.
Upgraded our conference by a million!
Everyone was super satisfied with the app on-site for our flagship event. We got the highest app adoption we've seen in years and no one was confused on where to go.
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Attendees really loved the 1:1 messaging and being able to connect to those virtually and in-person. Will never go back!
Agenda Issues
This app has so many technical issues. I cannot see the agenda after getting a new ticket and after hours of refreshing it still does not work. I'm in another country that I don't know and this app and it's agenda is the only sure way I know what is happening in my program. Now, I'm scared that I have to figure things out on my own and will get confused or lost in a place I'm not familiar with. This website and app also does not have a contact number to call, only an email. Overall, this app has only given me anxiety and stress, and I don't know what else to do. If you have the opportunity, please do not use this app. Opt for something better
App Privacy
The developer, Bizzabo Ltd., indicated that the app's privacy practices may include handling of data as described below. For more information, see the developer's privacy policy.
Data Linked to You
The following data may be collected and linked to your identity:
- Contact Info
- Usage Data
- Diagnostics
Data Not Linked to You
The following data may be collected but it is not linked to your identity:
- Identifiers
- Diagnostics
Privacy practices may vary, for example, based on the features you use or your age. Learn More
- Seller
- Bizzabo Ltd.
- Size
- Category
- Business
- Compatibility
- iPhone
- Requires iOS 13.0 or later.
- iPad
- Requires iPadOS 13.0 or later.
- iPod touch
- Requires iOS 13.0 or later.
- Mac
- Requires macOS 11.0 or later and a Mac with Apple M1 chip or later.
- Languages
- Age Rating
- 4+
- Copyright
- © Bizzabo Ltd. 2023
- Price
- Free


text:
Session 1:
Research Round-Robin: Concurrent Conversations with Six Nano Researchers
Session organizer: Larry Bell, Museum of Science, Boston
Get a taste of the latest developments in nano research! This round-robin session offers a chance for you to get overviews of current research in some of nano's leading fields: Nano and Society, Nano and Medicine, Nano and Materials, Nano Toxicity and Risk, and Nano and Nature. After a brief introduction, participants will break into groups, choosing two of five possible 45-minute discussions on the different research fields. You can focus your time on the two topics most interesting to you, or move from group to group.
- Clark Miller, Arizona State University (Nano and Society)
- Matt Francis, UC Berkeley (Nano and Medicine)
- Jeff Urban, Lawrence Berkeley National Labs (Nano and Materials)
- Steve Whitelam, Lawrence Berkeley National Labs (Nano and Nature)
- Ron Zuckerman,Lawrence Berkeley National Labs (Nano and Nature)
- Andrew Maynard, Project on Emerging Nanotechnologies (Nano Toxicity and Risk)
Session 2: Communicating Science Through Creative Performances
Session organizer: Rae Ostman, Sciencenter
Performance offers a vibrant path into science content and can help reach new audiences. Join us for this workshop, where we'll explore some opportunities for using performance as a vehicle to communicate scientific concepts. Cornell University physicist Dr. Itai Cohen and choreographer Maren Waldman will present The Dance of Scales, a performance that uses dance to investigate the movement of organisms on the nanoscale. Following the performance, Max Evjen and Megan Halpern of Redshift Productions will facilitate a hands-on activity and help you devise new ways of using the arts to communicate nano concepts.Presenters:
- Max Evjen, Redshift Productions
- Megan Halpern, Redshift Productions
- Itai Cohen, Cornell University
- Maren Waldman, Choreographer
Session 1: Exploring the Nano in Art and the Art in Nano
Session organizer: Stephanie Long, Science Museum of Minnesota
The visual and theatrical arts can provide an accessible and alternative entry point to science for learners of all ages by blending science, emotion, and aesthetics. In this session, we'll learn how a variety of institutions have integrated nano and art into their exhibits, programs, and projects. Examples range from coffee shop shows featuring research images as art to theatrical programming about the interactions between science and society to immersive experiences that engage the visitor as artist. We also want to hear what's worked for you and how NISE Net can help you as you seek to blend art and science. Share your inventive ideas, challenges, and strategies for bringing art and nano together.
- Catherine Hughes, International Museum Theatre Alliance
- Kathryn D. de Ridder-Vignone, Science & Technology Studies
- Tom Rockwell, Exploratorium
- Victoria Vesna, UCLA Art | Science Center
- Greta M. Zenner, University of Wisconsin-Madison
- Carol Lynn Alpert, Musuem of Science, Boston
- Stephanie Long, Science Museum of Minnesota
Session 2: ISE at the Intersection of Nano and Nature
Session organizer: Alex Fiorentino, Museum of Science, Boston
This session will bring participants to the fascinating intersection between nanotechnology and nature. This subject area can be particularly fertile ground for creating links between nano and existing ISE content, since so many ISE exhibits and programs already focus on biology that's related to these nano-phenomena. We'll explore examples of photonic materials based on butterfly wings, adhesives inspired by gecko feet, and DNA nanotechnologies. And we'll introduce you to a few existing programs, some created within the NISE Net and others created outside, that bring together concepts of nano and nature. Then we'll work together to devise innovative ways of tapping into the connection between nano and the natural world with the goal of engaging the public.
- Steve Whitelam, Lawrence Berkeley National Labs
- Dr. Rashmi Nanjundaswamy, Lawrence Hall of Science
- Dr. Mohan Srinivasarao, Georgia Tech
Session 3: Making Nano Relevant: Programs and Exhibits about Energy and the Environment
Session organizer: Catherine McCarthy, Sciencenter
How might nanotechnology impact the way we harness energy and affect the planet? Learn about products the NISE Network has developed to explore the potential benefits and challenges nano can bring to our approach toward energy and the environment. We'll have a product showcase featuring a forum, program, media, and exhibits. After the showcase, we'll discuss which energy and environment topics are of most interest to you and what approaches to these subjects you'd like to see the NISE Network pursue in the future. You'll get information on the products in the showcase to take home with you.
- David Sittenfeld, Museum of Science, Boston
- Karine Thate, Museum of Science, Boston
- Richard Hudson, Dragonfly TV
- Lisa Regalla, Dragonfly TV
- Catherine McCarthy, Sciencenter
- Jayatri Das, Franklin Institute
- Todd Kehoe, OMSI
- Paul Martin, Science Museum of Minnesota
Session 4: Tiny Fundamentals
Session organizer: Anders Liljeholm, OMSI
Schoolhouse Rock taught us that as our bodies get bigger, our minds grow and flower. But what happens when things get smaller--a LOT smaller? The changes to key properties of matter, such as surface area, surface tension, color, and more, make nano an incredible new realm for research and potential application. Join us for a hands-on learning session, looking at the fundamental science of the super-small. We'll show you our favorite demonstrations and discuss how you have, or could, adapt them to suit your institution.
- Anders Liljeholm, OMSI
- Keith Ostfeld, Children's Museum of Houston
Session 5: Why Should I Care?: Using Societal and Ethical Issues to Make Nano Relevant
Session organizer: Troy Livingston, North Carolina Museum of Life and Science
What stake do our audience members have in nano, and how can we use that stake to pique their interest? We'll begin this workshop with an overview of the ISE field's approach to Public Engagement in Science, and the way it encourages us to think about our audiences, speakers, and the programs we offer. Then we'll discuss examples of Societal and Ethical Implications (SEI) content in a variety of youth- and adult-focused programs, some developed by the NISE Network and some by other organizations. This session is designed to encourage a collaborative brainstorming-based workshop on how you might use SEI-based discussions in your programs at home and for us to learn how the NISE Network might support partners in overcoming obstacles to developing these programs.
- Brad Herring, North Carolina Museum of Life and Science
- Troy Livingston, North Carolina Museum of Life and Science
- Veronica Garcia-Luis, Exploratorium
Session 6: This Won't Hurt a Bit! Injecting Nanomedicine Into Public Awareness
Session organizer: Kari Jensen, OMSI
Amazing advancements in medical research have been made in recent years, thanks to nanotechnology. In this session, we'll address topics in the field of nanomedicine, including the detection and treatment of disease, tissue regeneration, and cancer treatment. Through exhibits, programs, community forums, and computer interactives, the NISE Network has been bringing nanomedicine to the public for the past four years. We'll take a look at each of these project areas and will review the successes and challenges of each. Finally, we'll discuss potential content areas and directions for future NISE projects on nanomedicine.
- Marilyn Johnson, Oregon Museum of Science and Industry
- Tim Miller, Divine Wind, LLC
- Carol Lynn Alpert, Museum of Science, Boston
- Jennifer Weil, Nanobiotechnology Center, Cornell University
- Ben Almquist, Melosh Group, Materials Science & Engineering, Stanford University
Session 1: Developing Full-Body Experiences to Reach Diverse Audiences
Session organizer: Rae Ostman, Sciencenter
Getting up off your chair can be a great way of learning. During this workshop, participants will brainstorm ways to use full-body experiences to explore nano concepts, focusing on creating experiences that are appropriate for specific audiences. We'll have a movement-based workshop being developed by choreographer Maren Waldman to engage middle school students in nanoscale science. Participants will also be able to take part in a design challenge facilitated by Redshift Productions, a duo of working artists who specialize in science communication and education.
- Max Evjen, Redshift Productions
- Megan Halpern, Redshift Productions
- Maren Waldman, Choreographer
Session 2: Engaging Science Attentive Adults in Everything Nano
Session organizer: Brad Herring, North Carolina Museum of Life and Science
Informal learning institutions don't only cater to youth, but that's often the public perception. How do we overcome this barrier and engage adults in nano programming? Learn how adult programming, from science cafes and forums to book clubs and science theater, has worked in a variety of institutions. Join us and take part in discussions about the successes and pitfalls of reaching out to adult audiences and explore ways in which we can better serve and reach the over-18 crowd. In this session, you'll have a chance to share your experiences, successes, challenges, and concerns with creating and engaging adults in everything nano.
- Brad Herring, Museum of Life and Science, Durham
- David Sittenfeld, Museum of Science, Boston
- Stephanie Long, Science Museum of Minnesota
- Marilyn Johnson, Oregon Museum of Science and Industry
- Meena Selvakumar, Pacific Science Center
Session 3: Nano Camps and Afterschool Programs
Session organizers: Jayatri Das, Franklin Institute, and Darrell Porcello, Lawrence Hall of Science
Summer camps and afterschool programs provide great opportunities for in-depth explorations of nanotechnology. In this session, several NISE Net institutions with ongoing programs share their approaches, curricula, and activities. Discover our great successes and cringe at our spectacular failures! And if you've run a nanocamp at your own institution, we encourage you to bring your experiences and materials to share with the group. Participants will get down and dirty with two of our favorite hands-on nanocamp activities: making nanosolar cells with raspberries and unravelling the unique properties of gold at the nanoscale. We will also discuss how these rich, long-term activities could be adapted for high-throughput audiences on the museum floor.
- Jayatri Das, Franklin Institute
- Darrell Porcello, Lawrence Hall of Science
Session 4: Back-to-School Nano: What to Offer School Groups
Session organizer: Marilyn Johnson, OMSI
Nano content presents unique opportunities and challenges for educators in a field trip environment. Join us in this open workshop, where we'll map out resources and strategies for creating nanotechnology-rich K-12 field trip experiences, with a special focus on grades 4-8. Share your successful approaches to attract and engage school groups in museum field trips focused on nanotechnology or other content areas.
- Marilyn Johnson, Oregon Museum of Science and Industry (OMSI)
- Shari Hartshorn, Science Museum of Minnesota
Session 5: NanoDays and Beyond
Session organizers: Margaret Glass, ASTC, and Anders Liljeholm, OMSI
NanoDays was originally conceived as a week of public events focused on a standard set of tabletop activities and cart demos. But many institutions have taken NanoDays beyond these materials and taken their events beyond the expected venues of the museum or university. At the same time, we realize that many of our potential target audiences for nano education don't live near urban center cities; sometimes we have to bring the nano to the audience. In this session, we'll see a visual showcase of NanoDays events and hear some success stories about how to move nano education to more far-flung locations year round.
- Several NanoDays organizers from throughout the Network
Session 6: Beyond Text: Using Audio to Enhance Nano Learning for All
Session organizer: Christine Reich, Museum of Science, Boston
How can you describe what's too small to see to someone visually impaired? How do you create labels for people who can't read English? Many museums rely on text to give visitors the information they need at exhibits. Yet text is only one of the many mediums that can be used for exhibit interpretation. NISE Net has gone beyond traditional text-based interpretation, using both English and Spanish audio labels. In this session, we'll review best practices for the development and evaluation of audio labels. We'll share our evaluation findings from testing that was conducted with the general public, visitors with low/no vision, and Spanish speakers. Session participants will then practice applying lessons learned through an interactive activity when they create their own audio labels and test those created by others.
- Lisa Wisniewski, Antenna Audio
- Scott Ewing, OMSI
- Kari Jensen, OMSI
Session 7: Marketing Nano Back Home: Selling Museum VIPs on the Very Small
Session organizer: Larry Bell, Museum of Science, Boston
What if nano just isn't on the radar screen of folks back home at your institution? They may not know what it is or find it relevant to your institution's work. In this session, we'll look at ideas and resources to help you build a case for nano back at your home institution. We'll spend the first part of the session in small groups discussing whose support you need and what interests, concerns, and needs are involved. Then together as a larger group, we'll look at resources to help you communicate about nano, including the special demo that initially got Larry's trustees buzzing. Back in small groups, we'll devise strategies for reaching key stakeholders and compose an "elevator pitch" to make your argument short and to the point. We'll hear everyone's inventive ideas and participants will walk away with a wealth of resources for building institutional support: strategies, a sample pitch, some Powerpoint slides, materials, Web links, and hands-on demos you can do at a desk or dinner table. You'll also get to help NISE Net shape our future work to best provide you with way to build institutional support for nano.
- Larry Bell, Museum of Science, Boston
Session 8: The Little Nano that Could: Younger Audiences and Nanotechnology
Session organizers: Keith Ostfeld, Children's Museum of Houston and Krystal Willeby, Children's Museum of Houston
The effort to engage our youngest visitors in the tiniest of technologies poses its own unique set of challenges. How can NISE materials and activities be "hacked" to make them more amenable to youngsters? In this session, we'll share our assessments of what gives an activity the most potential with younger audiences and show you how we massaged existing programs to better suit the needs of our younger visitors. Then you'll get a chance to browse an open showcase of child-oriented programs and ask whatever questions you have. We'll wrap up with a brainstorm about future nano topics that can be directed at younger audiences and identify participants interested in developing these kinds of programs in the future.
- Keith Ostfeld, Children's Museum of Houston
- Krystal Willeby, Children's Museum of Houston
- Catherine McCarthy, Sciencenter
- Steve Hale, Sciencenter


text:
Product Description
2017 IG Sneak Peek Templates is a set of six sneak peek templates designed to use with instagram.
Included are some floral patterns and wordarts that cannot be edited , otherwise all is editable.
– six 5″ x 5″ templates
– Clipping masks, easy to drop your photos in
– Created with Photoshop CC
– Names of the fonts included.
Adobe Elements Compatible.
All of my templates come with PRO PHOTOGRAPHER LICENCE which means you are allowed to use my designs in your photoraphy business ONLY as an add-on products to your sessions you sell to your exisiting clients only in the flattened printed form. Making profit from my designs other then the one stated above IS PROHIBITED! You are not allowed to sell them to third party clients , you are not allowed to use my designs or parts of it to create other designs/templates you sell in shops or other venues in digital form or printed form. No blog or website designs for sale. I do not offer commercial license for the aforementioned use. Thank you for respecting my terms of use.
Gorgeous photos courtesy of Lori Romney Photography, Brooke Bakken Photography and Haizel Creations.


text:
(480) 739-9939
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text:
Filter by Topic
- (-) Remove Processes filter Processes
- (-) Remove Reproduction filter Reproduction
- (-) Remove Theories filter Theories
Filter by Format
Fetal Programming
Fetal programming, or prenatal programming, is a concept that suggests certain events occurring during critical points of pregnancy may cause permanent effects on the fetus and the infant long after birth. The concept of fetal programming stemmed from the fetal origins hypothesis, also known as Barker's hypothesis, that David Barker proposed in 1995 at the University of Southampton in Southampton, England.
Format: Articles
Subject: Processes, Theories, Reproduction
The figure depicts three different molecular structures of estrogen found in mammals' that differ by the arrangement of bonds and side groups. The molecular structures of the three estrogen molecules differ by the arrangement of chemical bonds and side groups attached to the core steroid structure, cholesterol, which contains three cyclohexane rings and one cyclopentane ring.
Format: Graphics
Subject: Theories, Processes, Reproduction


text:
Serviços Personalizados
Links relacionados
- Citado por Google
- Similares em Google
SA Orthopaedic Journal
versão On-line ISSN 2309-8309
versão impressa ISSN 1681-150X
SA orthop. j. vol.14 no.4 Centurion Out./Nov. 2015
Epithelioid haemangioendothelioma of the scapula in a child: A case report and review of the literature
Dr MN RasoolI; Dr RF SnydersII; Dr G BydawellIII
IMBChB, FCS Orth(SA), PhD(UKZN) Consultant Orthopaedic Surgeon
IIMBChB Registrar Orthopaedics
IIIMBChB, FRCR (SA); Consultant Radiologist
Epithelioid haemangioendothelioma (EHE) is a vascular tumour which rarely affects bone. A 10-year-old girl presented with slow onset of swelling of the scapula for 6 months. Radiology revealed a destructive lesion of the scapula. Histology confirmed epithelioid haemangioendothelioma. Pre-operative transarterial embolisation was performed to decrease the vascularity of the tumour. The tumour was completely resected with the entire scapula. Post-operatively the child improved with useful function and a stable shoulder 13 months later. Large, isolated EHE of the scapula has not been reported in children.
Key words: epithelioid haemangioendothelioma, scapula, transarterial embolisation, scapulectomy
Epithelioid haemangioendothelioma (EHE), a rare tumour of vascular endothelial origin, is one of the lesser-known tumours of bone. The tumour pursues a clinical course between that of a haemangioma and an angiosarcoma. It occurs mainly in soft tissues such as the skin, liver and lung, but rarely in bone. The osseous lesions may be solitary but the majority are multi-centric.1-5 The lower limbs are more commonly involved. The scapula is a very rare site of involvement and this tumour is uncommon in children. One report only, occurring in the scapula, has been described in a child as part of a multi-centric involvement.6 EHE can be misdiagnosed as a metastatic carcinoma or primary sarcoma in children. Resection is still the primary modality of treatment. Radiotherapy is useful for surgically inaccessible sites. Profuse local bleeding at the time of biopsy or surgery has been reported.4,7,8
The aim of this report is to describe a rare site of involvement of EHE in the scapula, and the value of pre-operative transarterial embolisation (TAE) to decrease operative bleeding during scapulectomy.
Case report
A 10-year-old girl was referred from a rural hospital for a slow-growing, enlarging mass, associated with pain over the right scapula. Symptoms were present for 6 months. An open biopsy was done in the rural hospital. The report of the biopsy, which was done at the referral hospital, was inconclusive. The child was well, but slightly pale. The swelling was 20 cm x 15 cm x 12 cm fixed to the scapula and involving the supra- and infraspinous fossae (Figure 1). The skin was adherent to the tumour over the biopsy site only. Multiple dilated veins were present. Axillary and supraclavicular lymph nodes were not enlarged.
All shoulder movements were limited. There was no neurovascular involvement. The elbow and the hand function were good, though the arm muscles were wasted.
Plain radiographs of the right scapula showed a large tumour with destructive changes (Figure 2). MRI showed a multi-lobulated mass of heterogeneous signal intensity, with central necrosis but no calcification (Figure 3). The neuro-vascular bundle was displaced anteriorly. There was no infiltration of the chest wall. A pathological fracture of the glenoid neck was present.
The haemoglobin was 8 g/L and the ESR was 15 mm/hr. Staging investigations revealed that the lesion was confined to the scapula, with the bone scan showing no other areas of increased uptake. The tru-cut biopsy revealed haeman-gioendothelioma of bone on histology.
Using 300-500 and 500-700 micron particles, a trans-arterial embolisation was performed by an interventional radiologist. The tumour-feeding branches from the axillary artery was targeted, using a micro-catheter. This allowed a window period in which to surgically remove the tumour (Figures 4a and 4b).
A tumour resection was performed 6 days after the embolisation. The previous biopsy scar was excised and the incision was extended to the inferior angle of the scapula, and supero-laterally to the axilla. From infero-medially, the latissimus dorsi, rhomboids, levator scapulae and the trapezius were divided. The tumour was removed dividing the serratus anterior, reflecting the posterior deltoid from the acromion and dividing the rotator cuff. The lateral 2 cm of the acromion, together with the clavicle, remained after the resection of the entire scapula. The acromion was anchored posteriorly to the third rib with sutures to prevent drooping. Bleeding was noted to be mild to moderate and the wound was closed over a suction drain. The tumour weighed 1.3 kg.
Histology confirmed a low grade EHE of bone with no signs of mitosis. The tumour was non-encapsulated and the soft tissue margin was free from tumour.
Post-operatively the child made good progress and was immobilised in a broad arm sling for 4 weeks. There were no neurovascular problems. At 13 months follow-up, the child gained weight, shoulder flexion and extension were 30° each, internal rotation was 40° and external rotation 15°, abduction reached 20°, and passively the limb could be elevated to above the head (Figure 5). There was no recurrence, pain or instability of the joint (Figure 6).
Histology confirmed a low grade Ehe of bone with no signs of mitosis. The tumour was non-encapsulated and the soft tissue margin was free from tumour
EHE of bone is rare. The incidence is between 0.1% to 1% of all malignant primary bone tumours. This tumour is usually seen in soft tissues such as the liver and lungs. Bone lesions are usually multi-centric and have a predilection for long bones of the extremities, usually the lower limbs. Lesions are often located in the diaphysis, but may occur in the metaphysis or meta-epiphysis. Less frequently, this tumour is found in the vertebral column, the upper limbs, and flat bones.1-5, 7, 9, 10
The age distribution ranges from 10-73 years (mean 30 years).
EHE comprises two general groups, those of low grade malignancy, and those that are highly malignant and metastatic.4,7,8
Clinically the tumour is slow growing, and the time from initial symptoms to presentation is reported as 7 months to 8 years.1 Pathological fractures may be the presenting problem, but the major clinical manifestations of EHE of bone are pain and swelling. Microangiopathic haemolytic anaemia, consumption coagulopathy and high output cardiac failure due to arterio-venous shunts have been reported.9,11
Radiologically the lesions are osteolytic, expansile and multi-focal. Reactive new bone formation is rare. The lesions may be in cancellous or cortical bone. Occasionally, the radiological appearance is 'honeycombed' or may have 'ballooning' features with bulging of the thinned cortex.4-8 Calcification is occasionally seen in large, deeply situated tumours.6
Macroscopically the appearance of the tumour tissue is dark red or brownish. The consistency is soft but it may be firm if the cells are in dense collagen fibres. Profuse bleeding may be encountered during surgery.4, 8, 9
Microscopically, a rich network of anastomosing vessels, lined with atypical epithelial cells are seen, together with primitive vaso-formative features, and vascular channels showing various stages of angiogenesis. Silver staining of the vascular reticulin sheath is useful in distinguishing EHE from haemangiopericytoma and other vascular tumours.5,7
Deposits of haemosiderin may be noted.
Ultra-structurally the important feature is the presence of the vascular lumina showing various degrees of maturation. The endothelial nature of the tumour can be confirmed by the presence of Weibel-Palade bodies and Factor VIII related antigen in the vascular endothelial cells.5-7 Tumours are graded I-III, though histological grading can be difficult in Gr II and Gr III, and in the case of recurrence.4,5 High and low malignant areas may be present initially in the same tumour.5 The most important criterion for predicting the prognosis of EHE of the bone was visceral involvement.4,5
When metastasis occurs, it usually develops from the tumours with atypical features. Mitosis (>1 per HP field), focal spindling or cell necrosis are features of a more aggressive course. Metastases in regional nodes may occur in 30%. The overall survival for solitary EHE is 89% and 50% for those with multi-focal disease.
EHE can be misdiagnosed as metastatic carcinoma, due to its growth pattern and low mitotic activity. In children, Ewing's sarcoma, rhabdomyosarcoma, osteolytic osteosarcoma and skeletal angiomatosis must also be considered."12
In accessible regions, radical excision is the treatment of choice.4-7 Radiation treatment alone may be effective in some patients with multi-centric tumours. The potential for complications must be considered. The role of chemotherapy is not clear but it may be used to treat tumours involving multiple bones.
Limb-sparing resection of the scapula is rarely done in children. In an adult with sarcoma, Villalobos et al.13 performed a resection of the scapula and reconstruction using a customised scapula endoprosthesis. This is a useful alternative to forequarter amputation. The result was satisfactory with good elbow and hand function, though overhead activity was limited. The child in this report was able to perform activities of daily living with limitation of overhead activities. Cosmetically the outcome was more acceptable, and functionally superior to a forequarter amputation.
In accessible regions, radical excision is the treatment of choice.
Radiation treatment alone may be effective in some patients with multi-centric tumours
Trans-arterial embolisation (TAE) is one of the more important treatment modalities being used in the treatment of primary and secondary bone tumours.14-16 It reduces vascularity and intra-operative blood loss thereby allowing for better definition of tissue planes, and assisting in complete excision during surgery. The principles of TAE of bone tumours are the precise targeting of the occlusive embolic material to the tumour-feeding vessels. The aim is the occlusion of the tumour capillary bed, and not the major arterial feeders. Embolic agents used are either liquid or particulate. Occluding only the major vessels leads to vasculari-sation of the tumour via other vessels. Tumour types treated include metastatic lesions, giant cell tumours, aneurysmal bone cysts, vertebral haemangiomas, osteosarcomas and arterio-venous malformations.16 Lower operative blood loss and the decreased need for intra-operative transfusion were advantages in the excision of the tumour in this patient.
In conclusion, EHE is rare in children. Only one scapula lesion has been described in a child, as part of a multi-centric involvement.6 Primary solitary scapula lesions have only been described in adults.4,13 The child in this study had a large primary tumour isolated to the scapula. The morbidity of a forequarter amputation was avoided and the child has useful upper limb function.
1. Weiss SW, Ishak KG, Dail DH, Sweet DE, Enzinger FM. Epithelioid hemangioendothelioma and related lesions. Semin Diagn Pathol 1986;3:259-87. [ Links ]
2. Stout AP. Hemangio-endothelioma: a tumor of blood vessels featuring vascular endothelial cells. Ann Surg 1943;118:445-64. [ Links ]
3. Weiss SW, Goldblum JR Epithelioid Haemangio-endothelioma: Vascular tumours of Intermediate malignancy. Enzinger and Weiss. Soft Tissue Tumors 5th Edition: 2008 Chapter 23, pp 681-88. Mosby Elsevier. [ Links ]
4. Kleer CC, Unni KK, Mcleod RA. Epithelioid heman gioendothelioma of bone. Am J Surg Pathol 1996;20:1301- 11. [ Links ]
5. Campanacci M, Boriani S, Giunti A. Hemangio-endothelioma of bone: a study of 29 cases. Cancer 1980;46:804-14. [ Links ]
6. Tsuneyoshi M, Dorfman HD, Bauer TW. Epithelioid hemangioendothelioma of bone: a clinicopathologic, ultrastructural, and immunohistochemical study. Am J Surg Pathol 1986;10:754-64. [ Links ]
7. Garcia-Moral CA. Malignant hemangioendothelioma of bone. Review of world literature and report of two cases. Clin Orthop 1972;82:70-79. [ Links ]
8. Bundens WD, Brighton CT. Malignant hemangioen-dothelioma of bone: report of two cases and review of the literature. J Bone Joint Surg (Am)1965;47-A:762-72. [ Links ]
9. Srinivasan CK, Patel MR, Pearlman HS, Silver JW. Malignant hemangioendothelioma of bone: Review of the literature and report of two cases. J Bone Joint Surg (Am)1978;60-A:696-700. [ Links ]
10. Sweterlitsch PR, Torg JS, Watts H. Malignant hemangioendothelioma of the cervical spine. A case report. J Bone Joint Surg (Am)1970;52-A:805-808. [ Links ]
11. Lye DJ. Wepfer JF, Haskell DS. Low grade hemangioen-dothelioma of the clavicle and acromion. Case report 458, Skeletal Radiology 1988;17:57-59. [ Links ]
12. Volpe R, Mazabraud A. Hemangioendothelioma (angiosarcoma) of bone: a distinct pathologic entity with an unpredictable course. Cancer 1982;49:727-36. [ Links ]
13. Villalobos CE, Hayden BL, Silverman A, Choi I, Wittig JC. Limb-sparing resection of the scapula and reconstruction with a constrained total scapula prosthesis: A case of multicentric epithelioid hemangioendothelioma involving the scapula and surrounding soft tissues. Ann Surg Oncol 2009;16:2321-22. [ Links ]
14. Gupta P, Gamanagatti S. Preoperative transarterial Embolization in bone tumors. World J Radiol 2012;4:186-92. [ Links ]
15. Ibrahim WH, Safran ZA, Hasan H, Zeid WA. Preoperative and therapeutic embolization of extremities of bone and soft tissue tumors. Angiology 2013;64:151-56. [ Links ]
16. Owen RJ. Embolization of musculoskeletal bone tumors. Semin Intervent Radiol 2010;27:111-23. [ Links ]
Dr MN Rasool
Department of Orthopaedic Surgery
University of Kwa-Zulu Natal Nelson R Mandela School of Medicine
Private Bag 7 Congella, Durban, 4001
Tel: 031 260 4297
Email: email@example.com
No benefits of any form have been or are to be received from a commercial party related directly or indirectly to the subject of the article.


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Why can't you tell when an hour has passed without looking at a watch? Why are you able to do three things at once? Does coffee make time go faster? Neuroscientsts explain how our brains tell time - or don't.
It was a familiar feeling of surprise and dismay. Looking at the clock on my computer, I realized that the five minutes I'd spent finishing up an article had actually been 25 minutes. Now I was going to be late for my lunch meeting. As I raced down one of those insanely tall San Francisco hills to get to the restaurant, I wondered for probably the millionth time why I am always running late.
This time, I vowed, I was going to find out.
I turned to an obscure field of neuroscience for answers. The scientists who work on the problem of time in the brain sometimes refer to their area of expertise as "time perception" or "clock timing." What they've discovered is that your brain is one of the least accurate time measurement devices you'll ever use. And it's also the most powerful.
Why your perception of time will never be exact
When you watch the seconds tick by on a digital watch, you are in the realm of objective time, where a minute-long interval is always 60 seconds. But to your brain, a minute is relative. Sometimes it takes forever for a minute to be over. That's because you measure time with a highly subjective biological clock.
Your internal clock is just like that digital watch in some ways. It measures time in what scientists call pulses. Those pulses are accumulated, then stored in your memory as a time interval. Now, here's where things get weird. Your biological clock can be sped up or slowed down by anything from drugs to the way you pay attention. If it takes you 60 seconds to cross the street, your internal clock might register that as 50 pulses if you're feeling sleepy. But it might register 100 pulses if you've just drunk an espresso. That's because stimulants literally speed up the clock in your brain (more on that later). When your brain stores those two memories of the objective minute it took to cross the street, it winds up with memories of two different time intervals.
Image via Warren Meck.
And yet, we all have an intuitive sense of how long it takes to cross a street. But how do we know, if every time we do something it feels like it a slightly different amount of time? The answer, says neuroscientist Warren Meck, is "a Gaussian distribution" - in other words, the points on a bell curve. Every time you want to figure out how long something is going to take, your brain samples from those time interval memories and picks one. "You randomly sample from it," says Meck. "So you might pull a 25 out of distribution, or a 36. You're only accurate in the mean."
The good news is that, on average, you will predict correctly how long it takes to cross the street. The bad news is that occasionally, you'll pull an outlier memory from that bell curve and decide to cross the street much more slowly than you should.
Your intuitive sense of how much time something will take is taken at random from many distorted memories of objective time. Or, as Meck puts it, "You're cursed to be walking around with a distribution of times in your head even though physically they happened on precise time."
Why you can do three things at the same time
Your internal clock may be the reason why you can multitask. Because nobody - not even the lowly rat - has just one internal clock going at the same time.
At the very least, you've got two internal clocks running. One is the clock that tracks your circadian rhythms, telling you when to go to sleep, wake up, and eat. This is the most fundamental and important of all your internal clocks, and scientists have found it running even in organisms like green algae. The other clock you've likely got running is some version of the interval time clock I talked about earlier - the one that tells you how long a particular activity is going to take.
Working with Meck, neuroscientist Catalin V. Buhusi discovered in experiments with rats is that your brain can keep multiple interval time clocks going in a pretty complicated way. He trained rats to press three levers for food at three different intervals: one at 10 seconds, one at 30, and one at 90. After a learning phase, the rats were able to simultaneously time the intervals for all three levers, pressing one every 10 seconds, one every 30 seconds, and so on. More amazingly, the rats could stop, start, and reset those clocks. If the 30 second lever stopped, they would continue right along with the 10 and 90 second ones. And when the 10 second lever stopped and then started again, the rats could recalibrate the time of each interval and start pressing that lever at the appropriate speeds again. What this demonstrated to Buhisi was that rats can run many internal clocks at once. And humans can too.
Right now, it's likely that you are running at least three clocks: Circadian, plus a clock that's timing how long it's taking you to read this article, plus a clock telling you how long you have until you get home from work. And who knows what else you are keeping track of? If you're tapping your foot and doing a task in the background, that would add two more clocks.
Your ability to do many tasks at the same time hinges on this talent for juggling multiple clocks. It should come as no surprise, then, that the neural networks in your brain that assist in time perception are the same networks that allow you to plan and coordinate your physical movements. Your sense of time and your ability to act are connected at a very deep level in your brain. Put simply, timing two things at once and doing two things at once are, from your brain's point of view, pretty much the same thing.
Why coffee makes time go faster, and Alzheimer's makes it slower
I already told you that I'm late all the time, so I might as well admit more of my foibles: I drink coffee and I smoke pot. Not surprisingly, given my problems with being on time, both of these drugs are known to affect the speed of internal clocks.
It turns out that changing the speed of your internal clock affects your memories, too. Let's start with caffeine, which makes your internal clock go faster. If your brain normally stores 60 pulses for 60 seconds, your brain on caffeine stores 100 pulses. Two things happen as a result. First, when you retrieve your time memory, that minute will seem shorter than the 60 seconds it actually took. So a speedy clock means that time gets faster. Second, your memories get more granular. In one minute, you are storing 100 pulses, which add up to more data storage in your brain per second. Coffee and other stimulants make you remember more. On the flip side, an antipsychotic drug like haloperidol slows down your internal clock and makes that minute seem much longer (though far less memorable).
Caffeine and haloperidol affect only clock speed, mostly by messing with the dopamine system in your brain. But you can distort time just by manipulating memory, too. The acetylcholine system in your brain regulates how time-based memories are stored. It turns out that one of the primary causes of memory loss in Alzheimer's comes from a lack of the memory-saving enzyme acetylcholine in the brain. People with Alzheimer's have internal clocks that are running just fine, but they are saving memories from those clocks much more slowly. That's why people with Alzheimer's have a hard time judging how long things will take. And why their memories are so vague.
One common treatment for Alzheimer's memory loss is to take supplements that boost acetylcholine in the brain. These supplements can sharpen anybody's memory without ever giving you that "speedy" effect of caffeine because they never touch the dopamine system. They send more chunks of time to memory without ever speeding up your internal clock.
The interesting thing about smoking pot is that marijuana is one of those rare drugs that seems to interact with both the dopamine and the acetylcholine system, speeding up the former and slowing down the latter. That's why when you get stoned, your heart races but your memory sucks.
Why you hear faster than you see
It's easy to distort the way your brain perceives time, but this organ is also remarkably accurate when it comes to figuring out what's happening to you millisecond by millisecond. Virginie van Wassenhove is a biologist who has studied how the brain figures out the order of events that happen in under a second's time - and has discovered that what you see and hear can change the way you perceive time.
One of the weirdest aspects of time perception is that your brain sees things much more slowly than it hears them. As van Wassenhove put it, "If you present a beep and a flash to somebody, then record from their cortex, you'll find that activity in the visual area will respond 50 milliseconds later. But the auditory cortex responds 12 milliseconds later." So your brain processes what you see more slowly than it processes what you hear.
Nobody is sure why this is. Van Wassenhove speculates, "Maybe it's about the difference between the speed of sound and light. The auditory system involves transduction, and doesn't take much time. Maybe it's about photochemistry in the eyes. There may just be differences in processing time required."
And yet, despite this discrepancy, your brain can still perceive the order of flashes and beeps that are only 20 milliseconds apart. Despite the fact that there's a 38 millisecond time lag between what you hear and what you see, your brain can still figure out if a something burst into flame 25 milliseconds before there was a loud popping noise.
Remember, this is all happening in under a second. So this same brain that isn't sure how long it takes to cross the street is able to pinpoint the order of events down to a few milliseconds.
In a series of experiments, Van Wassenhove and her colleagues found that what you see can change time perception. For example, if an object is looming in your vision and appears to be getting closer, perceptive time gets slower. The same goes for a sound that gets louder. The reason for this is simple: When you pay close attention to something, time is distorted.
It seems that paying attention to visual inputs can even distort the meaning of sounds. Say you're looking at an enormous airplane zooming toward you. Time will dilate even if you hear a sound that suggests the object is receding, such as the engine getting fainter.
Why I am often late
So let's return to my original burning question, as I plummet down the hill to my lunch meeting. Why am I always late? One possibility is that all my coffee-drinking and pot-smoking has permanently affected my ability to figure out how long things will take. I'm speeding up my clock so often, and slowing down my memory-storing acetylcholine system so frequently, that my memories of time intervals have gone random. When I sample an interval from that Gaussian distribution, I get something truly misleading, which causes me to miscalculate how much time it will take to get to lunch.
Though this scenario would probably make "just say no to coffee" campaigners very happy, it turns out to be unlikely. In experiments with rats, Meck observed that the rodents' brains began to compensate for time distortions caused by drugs that slowed or sped up internal clock time. Once my internal clock is used to operating at a faster speed due to caffeine or marijuana, it adjusts and provides me with a reliable average time interval for events.
In fact, it seems more likely that the culprit in my case can be explained by van Wasserhove's experiments with attention and time distortion. Remember, the looming object that occupies your attention can cause time to slow down subjectively. Paying attention to something can make time seem to speed up, too.
When I asked van Wasserhove to offer some ideas about why I'm always late, she said it could have to do with what I'm paying attention to. She explained:
If you go on your first romantic date, time is going to be very fast because you're not paying attention to it. You're having an interesting discussion or something and you don't think about time. But at the doctor's office you really keep track as you wait for an appointment. If you pay attention to time it slows down.
In my case, I was paying attention to writing an article, and what I thought was five minutes turned out to be 25. From the perspective of my brain, focused attention is like a drug. It sped my internal clock up, giving me a distorted sense of how many minutes had passed.
So how do I prevent myself from being late? Even though my brain is running many internal clocks, it turns out there's a good reason why I carry an external, objective clock too. By consulting my digital watch, I correct the distortions I'm doomed to experience as a creature whose temporal sense is generated by an imprecise, biological mechanism.
Which made me realize that clocks may well be humankind's oldest brain-enhancing technology. They allow our brains to experience something we never could without machines: Objective time.
Image by Daniel Spitzer
This io9 Flashback originally appeared in November 2010.


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In the main business area of Pamplona
The Zenit Pamplona Hotel is located in the Parque Comercial Galaria, right in the business centre of Pamplona, five minutes from the city centre and only about three minutes from the Noain International Airport. It is very easy to get to from the A-15 motorway.
From Zaragoza: Follow the A-15 and take exit 83B towards Pamplona. Carry straight on and take the first exit NA-33 towards Polígono industrial de Mutilva Baja. There will be a roundabout next to the La Morea shopping centre. Carry straight on and keep the shopping centre on your right. On crossing the roundabout, the Zenit Pamplona Hotel will be on your left.
From San Sebastián Donostia/Vitoria-Gasteiz: Follow the A15 and take exit 83. At the first roundabout, turn left, and at the second roundabout, take the first right, following directions to Pamplona. Follow the La Morea-Mutilva exit.


text:
By Karen Rebelo
Feb 26 (Reuters) - Vedanta Resources Plc (Other OTC: VDNRF - news) 's founder and largest shareholder, Anil Agarwal, has steadily built up his stake in the London-listed mining and oil and gas firm this year, recent filings from the company show.
The scrap metal-dealer-turned-billionaire has made multiple stock purchases in January and February, raising his stake in the company to 68.46 percent as of Feb. 20 from 66.93 percent at the start of the year.
The latest regulatory filing, published on Wednesday, showed that Agarwal purchased 210,000 shares at 851.48 pence per share on Feb. 20 through his investment vehicle, Volcan Investments Ltd.
Vedanta's stock closed at 842 pence on Wednesday on the London Stock Exchange (Other OTC: LDNXF - news) .
The company, grappling with regulatory hurdles and low commodity prices, was one of three miners to be demoted from the FTSE-100 index last year. Its stock has lost nearly a third of its value in the last 12 months.
Liberum analyst Ben Davis said that the latest purchases by Agarwal might be an attempt to signal to investors that Vedanta's stock has been oversold.
While promoters buying shares in their companies to shore up their stock price is nothing new, the frequency of Agarwal's purchases has prompted trader chatter that he may be looking to make an offer to take the firm private.
Neither Vedanta nor Volcan Investments were available for comment when contacted by Reuters.
Taking the company private would severely restrict Vedanta's access to public funds. It would also clash with Agarwal's ambition of growing the company to compete with the likes of Rio Tinto and BHP Billiton (NYSE: BBL - news) .
UK listing requirements mandate that at least 25 percent of a company's stock be available for trading.
The next biggest shareholders in Vedanta are Standard Life (LSE: SL.L - news) Investments Ltd, with a 7.85 percent stake, and BlackRock (Berlin: BLQA.BE - news) Investment Management (UK) Ltd with a stake of over 4 percent.
GIC Private Ltd, Capital World Investors and Credit Suisse (NYSE: CS - news) Asset Management each have a stake of more than 2 percent in the company, according to Thomson Reuters (Frankfurt: TOC.F - news) data.
Independent directors at Essar Energy (LSE: ESSR.L - news) , the other Indian resources company in the FTSE-250 index, this week shot down a bid from its largest shareholder and founders, India's billionaire Ruia brothers, saying the offer undervalued the company.


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Here at Friendly Planet Travel, we try to make every day Earth Day. Our tours are designed to show our travelers some of the most beautiful sights of the world. So we must take care of them. Thats why were firm believers in sustainable travel.
Sustainable travel is a much-discussed concept that is, actually, a great deal more complex than recycling your trash, or trying to use your hotel towels more than once. Not that those arent cardinal rules of all decent world travelers, but if you live in New York and want to visit Thailand, theres no way to avoid the long, environmentally costly flight.
But it is possible to tread softly once at your destination. And by treading softly, I mean treating not only the land, but the people, with respect and dignity.
Friendly Planet Travel tours all rely on local companies, local guides, and as many locally owned and run hotels and attractions as we can possibly arrange, so that the people who live in the places were visiting enjoy the benefit of our visits. By manifestly supporting local communities, they will become better stewards of the resources that give them back a decent living.
We also believe in supporting local communities by contributing to important local projects that provide material help, like digging wells, supplying schools, and contributing to self-help projects for the least privileged. We are motivated every day in our efforts at creating our tours by the belief that in getting to know people and cultures that are different from our own, we build our own small but important bridges toward a healed planet.
We already offer many touring opportunities to such destinations as Borneo and Patagonia, where the fragility of the environment is poignantly obvious to the casual visitor.
In the coming months, we hope to add new and exciting special eco-tourism opportunities, so stay tuned for more details here on the blog, on our Web site, and on Twitter.


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Course Overview
On our TESOL and English Literature degree with a year abroad, you will be able to gain the knowledge and skills to teach English as a second language, as well as exploring aspects of English literature from gothic fiction to creative writing.
Teaching English is a great way to see the world and this degree will provide practical and transferable skills to open up a range of exciting career opportunities.
During your four-year degree you'll learn about theory and practice, language teaching methodology, vocabulary, grammar and meaning, psycholinguistics, first and second language acquisition and discourse analysis.
You will spend your third year studying in Europe or the USA – an exciting and rewarding experience, which will further enhance your career prospects.


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The Advanced Cooperative Arctic Data and Information Service (ACADIS) team continued to expand data management planning, sharing, and preservation support for all projects funded by the Arctic Sciences Section in NSF's Division of Polar Programs (POL). ACADIS, a joint effort by the National Snow and Ice Data Center (NSIDC) and the University Corporation for Atmospheric Research (UCAR), is entering the third year of a four-year continuing grant awarded by NSF in July 2011.
Recent ACADIS team activities were focused on simplifying data submission at the ACADIS Gateway. The improved services include:
An improved tool to support authoring metadata.
Expanded capabilities and control for authorized Principal Investigators.
A new template to assist investigators in developing the Data Management Plan required for all NSF proposals.
An updated guide for data providers featuring at-a-glance instructions on how to contribute data.
The Arctic Data Explorer (ADE), a new data search tool launched at the Arctic Observing Summit (AOS) in April 2013 .
To give feedback or submit data, contact ACADIS Support at: support [at] aoncadis.org.
ACADIS data management services were highlighted in two data management white paper submissions for the AOS2013 and in the U.S. Arctic Research Plan: FY2013-2017.
For more information, see the ACADIS website or contact support [at] aoncadis.org.


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If you love Annie's Homegrown like I do you NEED to know about this deal! Their mac n cheese is a favorite of so many people! It is yummy and a bit healthier than most other boxed noodle dishes – and now you can get it in the microwave packets. My kids love this! It's a deal at under $1 a box! The price below is listed with the 15% Subscribe & Save savings – you get that by subscribing to just 5 items in a month! Clip the $1.50 coupon to get this price!
Get on over to Amazon and get Annie's Macaroni and Cheese, Shells & White Cheddar Mac and Cheese (Pack of 12) – Just $11.19!
NOTE: With Amazon Subscribe & Save, you save an additional 5% off the price and get free standard shipping. You are free to cancel at any time. After placing your order, wait until your order ships. Then, you can go into your Amazon Account page and click the "Manage Subscribe and Save" link and cancel it. That way you won't have continual shipments of your order in the future.
PLUS, remember, if you have 5 or more Subscribe & Save items that arrive in the same month, you will save an additional 15% (instead of 5%).
This item will ship free for all Amazon Prime members. Or, regular members can score free shipping by adding $25 or more worth of eligible items to your cart. You can get a 30-day free trial of Amazon Prime here.


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|by Dan Whipple
February 22, 2000
"Remote sensing is really the only way to study the mesosphere on a global basis," says David Siskind, a research physicist with the U.S. Naval Research
Laboratory. "The UARS [Upper Atmosphere Research Satellite] satellite has
revolutionized our view of the mesosphere. It's been a tremendous boon to
research at those altitudes (90-100 km above the Earth's surface) because the UARS satellite has a lot of instruments
capable of remotely sensing mesospheric altitudes."
This graphic shows the approximate location of the Aurora Borealis in relation to the mesosphere and thermosphere. (Image adapted from Robert Simmon, Goddard Space Flight Center).
Researchers at NASA's Goddard Space Flight Center use UARS data to study the coupling of atmospheric layers. For more information, visit the Goddard Space Flight Center DAAC (now named the GSFC Earth Sciences DAAC).
The image in the title graphic shows the tail of the Space Shuttle Discovery over the Aurora Australis.
Siskind and his group were the first to test one of the new generation
two-dimensional chemistry models against mesospheric observations of trace
constituents. A two-dimensional (2D) model represents the atmosphere by
considering vertical and latitudinal (north-south) coordinates, Siskind explains.
Two-dimensional models are the simplest type of model that can realistically
handle both chemical and meteorological effects. Combining relative simplicity
with detailed physics and chemistry, 2D models have long been the workhorses of
stratospheric science, and were the basis for many ozone assessments.
An example of a more complicated model is a three-dimensional (3D) model, which includes an additional longitudinal (east-west) coordinate. A practical example of a 3D model is a weather forecasting model.
"The model we used was one of the first to combine some of the meteorological effects normally only considered in a 3D model, with the standard two-dimensional model. This 'next generation' 2D model has sometimes been called a two-and-one-half-dimensional model," Siskind says.
The research aimed at discovering to what extent compounds produced in the thermospherewhich many people consider outer spacemigrate to the middle and lower atmosphere and react with chemicals there. For instance, "nitric oxide has been postulated to do just this," he said.
"We studied the coupling between different layers of the atmosphere. The overall question is, 'To what extent is stratospheric ozone sensitive to processes occurring, for example, in the aurora borealis?'"
An early theory hypothesized that nitric oxide produced in the aurora borealis was related to creation of the ozone hole, Siskind says.
"It was never a mainstream theory," he says, "but some of the processes in the theory do occur. The aurora borealis is not responsible for the ozone hole, but some evidence exists that, at least on a localized scale, some coupling of atmospheric layers occurs."
"While coupling is confirmed, it may be less than previously estimated," Siskind said. For example, Siskind's results indicated coupling only in the Southern and not the Northern Hemisphere, a phenomenon that remains to be explained.
The result surprised scientists. Siskind suspects that different meteorological conditions might account for the different couplings between aurora and stratosphere seen in the Northern and Southern Hemispheres. His research indicates that horizontal mixing is the mechanism whereby nitric oxide is carried from dark, winter polar regions to lower latitudes, where strong sunlight breaks the chemical bonds by photodissociation. (Photodissociation is the process by which sunlight breaks complex molecules in the atmosphere into simpler molecules). This mixing is believed to be more rapid in the Northern Hemisphere and therefore may lead to more destruction of nitric oxide, he says.
The researchers' next step is to see how the coupling between aurora and stratosphere varies from year to year. "For example, does it vary in concert with the sunspot cycle? Our calculations were for idealized conditions; now we are going to incorporate year-to-year variability in sunspot activity into the model," Siskind says.


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Antibody Persistence after Serogroup C Meningococcal Conjugate Immunization of United Kingdom Primary-School Children in 1999-2000 and Response to a Booster: A Phase 4 Clinical Trial
Perrett KP., Winter AP., Kibwana E., Jin C., John TM., Yu LM., Borrow R., Curtis N., Pollard AJ.
Background. After immunization with serogroup C meningococcal (MenC) conjugate vaccine, antibody responses and vaccine effectiveness are sustained in adolescents, in contrast to rapid waning in young children. We investigated the persistence of serum bactericidal antibody (SBA) titers in children 6 years after immunization with MenC vaccine (primed between 2 months and 6 years of age). The response to a Haemophilus influenzae type b-MenC conjugate (Hib-MenC) booster was also measured. Methods. A phase 4 clinical trial was conducted among 250 healthy 6-12-year-old children. SBA titers were measured before, 1 month after, and 1 year after Hib-MenC administration. The correlate of protection was an SBA titer of ≥8. Results. An SBA titer of ≥8 was observed in 61 (25% [95% confidence interval {CI}, 20%-30%]) of 244 participants (mean age, 9.1 years; mean interval since MenC immunization, 6.75 years). The proportion with an SBA titer of ≥8 and the SBA geometric mean titer increased with age, from 12% (95% CI, 4%-23%) to 48% (95% CI, 29%-67%) and from 2.90 (95% CI, 2.11-3.99) to 17.20 (95% CI, 6.80-43.5), respectively, from a mean age of 7.0 to 12.1 years. One month after the Hib-MenC booster, all participants had an SBA titer of ≥8, which was sustained in 99.6% at 1 year. Conclusions. As a result of waning antibody, the majority of 6-12-year-old children in the United Kingdom have inadequate serological protection against MenC. The persistence of MenC immunity and the response to a Hib-MenC booster is dependent on age at priming. A booster was highly effective in this cohort and could sustain population immunity against MenC disease. Trial registration. Current Controlled Trials (http://www.controlled-trials.com) identifier: ISRCTN72858898. © 2010 by the Infectious Diseases Society of America. All rights reserved.


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Your life as a
made easier!
Your life as a
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All kinds of talented musicians are waiting to connect with you!
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Studios, rehearsal spaces, luthiers, producers, stores, venues, suppliers and many more. Find the services you are looking for, or pin your business on the map!
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Boris Vladimirovich Asafiev (1884-1949) was a composer and writer.
Boris Asafiev lived in the Soviet Union where he had a strong musical influence. His writings include The Book about Stravinsky and Glinka. His compositions were mainly ballets and guitar compositions, and include Flames of Paris, based on the French Revolution, and The Fountain of Bakhchisarai, which was first performed in 1934, and was performed at the Mariinsky Theatre in St Petersburg in 2006.


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TSM is a lifestyle collection of accessories for men and women, which embodies the style and spirit of its founders Carl Hederoth, Charlotta Rosenblad and Boris Bencic. Perceiving a void in the market for a sophisticated Swedish aesthetic at an accessible price point, they brought together an international team of creative individuals. Carl Hederoth wanted to create stylish yet functional accessories for women and men of all ages. They found common values in the Swedish-ness;
Sweden is beautiful
Sweden is fair
Sweden is a personal experience
For T S M Leather Goods function is paramount as is understated sophistication. All products contain a perfect combination between aesthetics and functionality with design based on Swedish design principals such as balance and function. Sizes, shapes, pockets and handles are carefully designed to provide maximum comfort and convenience. Leathers are chosen from well-known tanneries in Italy and Spain and all metalwork, like buckles, attachments and feet are personalized and handcrafted. T S M bags embody contemporary European bag design with surreal detailing.
TSM is currently sold in at a number of selected stores throughout Europe, the United States and Japan


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SPEC CPU2006 and CPU2017 Flag Description - Platform settings for New H3C systems
Operating System Tuning Parameters
cpupower frequency-set
cpupower utility is a collection of tools for power efficiency of processor. frequency-set sub-command controls settings for processor frequency. "-g [governor]" specifies a policy to select processor frequency. The performance governor statically sets frequency of the processor cores specified by "-c" option to the highest possible for maximum performance.
This kernel option sets adaptive tick mode (NOHZ_FULL) to specified processors. Since the number of interrupts is reduced to ones per second, latency-sensitive applications can take advantage of it.
Firmware / BIOS / Microcode Settings
Enhanced Halt State (C1E)
Enabling this option which is the default allows the processor to transmit to its minimum frequency when entering the power state C1. If the switch is disabled the CPU stays at its maximum frequency in C1. Because of the increase of power consumption users should only select this option after performing application benchmarking to verify improved performance in their environment. The default is "Enabled".
DCU Streamer Prefetcher
This BIOS switch allows 2 options: "Enabled" and "Disabled". The default is "Enabled".
This prefetcher is a L1 data cache prefetcher, which detects multiple loads from the same cache line done within a time limit, in order to then prefetch the next line from the L2 cache or the main memory into the L1 cache based on the assumption that the next cache line will also be needed.
Hardware Prefetch
Lightly threaded applications and some benchmarks can benefit from having the hardware prefetcher enabled. Default is Enable.
Adjacent Cache Prefetch
Lightly threaded applications and some benchmarks can benefit from having the adjacent cache line prefetch enabled. Default is Enable.
Hardware P-States
This BIOS switch allows 4 options: "Native Mode", "Disabled", "Out of Band Mode" and "Native Mode with No legacy Support". The default is "Native Mode".
With Hardware Power Management(HWPM) the processors provides a flexible interface between Hardware and Platform for performance management and improving energy efficiency.
In Native Mode the HWPM operates cooperatively with the OS via a software interface to provide constraints and hints.
When disabled, system does not use HWPM.
EIST PSD Function
Function of the Enhanced Intel SpeedStep Technology (EIST).
EIST reduces the latency inherent with changing the voltage-frequency pair (P-state), thus allowing those transitions to occur more frequently. This allows for more granular, demand-based switching and can optimize the power-to-performance balance, based on the demands of the applications.
Power Supply Mode (Default = Balanced Performance)
This BIOS switch allows 4 options: "Balanced performance", "Performance", "Balanced Energy" and "Energy Efficient". The default is "Balanced Performance" optimized to maximum power savings with minimal impact on performance. "Performance" disables all power management options with any impact on performance. "Balanced Energy" is optimized for power efficiency and "Energy Efficient" for power savings. The BIOS switch is only selectable if the BIOS switch "Power Technology" is set to "Custom".
The two options "Balanced Performance" and "Balanced Energy" should always be the first choice as both options optimize the efficiency of the system. In cases where the performance is not sufficient or the power consumption is too high the two options "Performance" or "Energy Efficient" could be an alternative.
IMC Interleaving
This BIOS option controls the interleaving between the Integrated Memory Controllers (IMCs). There are two IMCs per socket in Skylake Server. If IMC Interleaving is set to 2-way, addresses will be interleaved between the two IMCs. If IMC Interleaving is set to 1-way, there will be no interleaving. If SNC is disabled, IMC Interleaving should be set to 2-way. If SNC is enabled, IMC Interleaving should be set to 1-way. This BIOS switch allows 3 options: "Auto" , "1-way Interleave" and "2-way Interleave". Default setting is "Auto".
Hyper-Threading [all]
This BIOS option enables or disables additional hardware thread which shares same physical core. Generally "Enabled" is recommended but disabling it makes sense for the application which requires the shortest possible response times. Default setting is "Enabled".
Link Frequency Select
This switch allows the configuration of the Intel Ultra Path Interconnect (UPI) link speed. Default is auto, which configures the optimal link speed automatically. It can be set "9.6 GT/s", "10.4 GT/s" or "Auto".
LLC dead line alloc
This BIOS switch allows 2 options: "Enabled" and "Disabled". The default is "Enabled". In the Skylake non-inclusive cache scheme, the mid-level cache (MLC) evictions are filled into the last-level cache (LLC). When lines are evicted from the MLC, the core can flag them as "dead" (i.e., not likely to be read again). The LLC has the option to drop dead lines and not fill them in the LLC. If the Dead Line LLC Alloc feature is disabled, dead lines will always be dropped and will never fill into the LLC. This can help save space in the LLC and prevent the LLC from evicting useful data. However, if the Dead Line LLC Alloc feature is enabled, the LLC can opportunistically fill dead lines into the LLC if there is free space available.
Package C State
This BIOS option allows 6 options: "C0/C1", "C2", "C6(non Retention)", "C6(Retention)", "No Limit" and "Auto". The default setting is "Auto". Package C-states is one of energy-saving options of the processor, which not only allow the individual cores of a processor, but the entire processor chip to be put into a type of sleep state. As a result, power consumption is even further reduced. But the "waking-up time" that is required to change from the lower package C-states to the active (C0) state is even longer in comparison with the CPU or core C-states. If the "C0" setting is made in the BIOS, the processor chip always remains active. It can improve the performance of latency sensitive workloads.
Patrol Scrub
This BIOS option enables or disables the so-called memory scrubbing, which cyclically accesses the main memory of the system in the background regardless of the operating system in order to detect and correct memory errors in a preventive way. The time of this memory test cannot be influenced and can under certain circumstances result in losses in performance. The disabling of the Patrol Scrub option increases the probability of discovering memory errors in case of active accesses by the operating system. Until these errors are correctable, the ECC technology of the memory modules ensures that the system continues to run in a stable way. However, too many correctable memory errors increase the risk of discovering non-correctable errors, which then result in a system standstill.
Stale AtoS
This BIOS switch allows 2 options: "Enabled" and "Disabled". The default is "Disabled".
The in-memory directory has three states: I, A, and S. I (invalid) state means the data is clean and does not exist in any other socket's cache. A (snoopAll) state means the data may exist in another socket in exclusive or modified state. S (Shared) state means the data is clean and may be shared across one or more socket's caches.
When doing a read to memory, if the directory line is in the A state we must snoop all the other sockets because another socket may have the line in modified state. If this is the case, the snoop will return the modified data. However, it may be the case that a line is read in A state and all the snoops come back a miss. This can happen if another socket read the line earlier and then silently dropped it from its cache without modifying it.
If Stale AtoS feature is enabled, in the situation where a line in A state returns only snoop misses, the line will transition to S state. That way, subsequent reads to the line will encounter it in S state and not have to snoop, saving latency and snoop bandwidth. Stale AtoS may be beneficial in a workload where there are many cross-socket reads.
Sub NUMA Cluster
Sub NUMA Cluster (SNC) breaks up the last-level cache (LLC) into two disjoint clusters based on address range, with each cluster bound to one memory controller. SNC improves average latency to the LLC/memory and is a replacement for the "Cluster On Die" (COD) feature found in previous processor families. For a multi-socketed system, all SNC clusters are mapped to unique NUMA domains. IMC Interleaving must be set to the correct value to correspond with SNC enable/disable. If SNC and IMC Interleave are both set to Auto, the result will be SNC disabled (only one cluster per socket) with 2-way IMC interleave. If SNC is set to Enable, IMC Interleave should be set to 1-way, which will result in two clusters per socket. The BIOS switch "Sub NUMA Clustering" allows 3 options: "Auto", "Enabled" and "Disabled". The default setting is "Disabled".
Intel VT for Directed I/O (VT-d)
This BIOS option enables or disables I/O virtualization functions of the CPU. If the server is not used for virtualization, this option should be set to "Disabled". Default setting is "Enabled".
This BIOS option enables or disables additional virtualization functions of the CPU. If the server is not used for virtualization, this option should be set to "Disabled". This can result in energy savings. Default setting is "Enabled".
Trusted Execution Technology
Enable Intel Trusted Execution Technology (Intel TXT). The default setting is "Disabled".
XPT Prefetch
This option configures the processor Xtended Prediciton Table (XPT) prefetch feature. The XPT prefetch exists on top of other prefetchers that that can prefetch data in the core DCU, MLC, and LLC. The XPT prefetch will issue a speculative DRAM read request in parallel to an LLC lookup. This prefetch bypasses the LLC, saving latency. In some cases, setting this option to disabled can improve performance. In some cases, setting this option to disabled can improve performance. Typically, setting this option to enable provides better performance. This option must be enabled when Sub-NUMA Clustering is enabled. This BIOS switch allows 3 options: "Disabled", "Enabled", and "Auto". The default is "Auto". By default, When CPU type is skylake, Auto is disabled. When CPU type is cascade, Auto is enabled. Enabled: Allows a read request sent to the LLC to speculatively issue a copy of the read to the memory controller requesting the prefetch. Disabled: Does not allow the LLC to speculatively issue copies of reads. Disabling this will also disables Sub-NUMA Cluster (SNC).
LLC Prefetch
This BIOS option configures the processor last level cache (LLC) prefetch feature as a result of the non-inclusive cache architecture. The LLC prefetcher exists on top of other prefetchers that can prefetch data into the core data cache unit (DCU) and mid-level cache (MLC). In some cases, setting this option to disabled can improve performance. Values for this BIOS option can be: Disabled: Disables the LLC prefetcher and forces data to fill in the MLC. The other core prefetchers are unaffected. Enabled: Gives the core prefetcher the ability to prefetch data directly to the LLC. By default, LLC prefetch option is Disabled.
DCA(Direct Cache Access) capable I/O devices such as network controllers can place data directly into the CPU cache, which improves response time. Enabling this option allows processors to increase I/O performance by placing data from I/O devices directly into the processor cache. This setting helps to reduce cache misses. The default setting is "Disabled".
Workload Configuration
Controls the aggressiveness of the energy performance BIAS settings. This bit field allows the Basic Input-Output System (BIOS) to choose a configuration that may improve performance on certain workloads. Can be UMA or NUMA. The default is "UMA".
Autonomous Core C-State
This BIOS switch allows 2 options: "Enabled" and "Disabled". The default is "Disabled". Enabled: HALT and C1 request get converted to C6 requests in hardware. Disabled: only C0 and C1 are used by the OS. C1 gets enabled automatically when an OS autohalts.


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123 HP Officejet 4655 Wireless Setup
To be able to print files and documents effortlessly, it is important to connect the HP Officejet 4655 to wifi network. This allows access to send files and documents wirelessly to the 123, hp.com/oj4655 printer device. Follow the simple steps below to help HP Officejet 4655 Wireless Setup.
2.Wireless Setup
3.WPS Pin
- At first, download the driver to configure device compatibility.
- Choose either basic or recommended driver to complete the download and setup.
- later, follow the instructions for wireless setup and end with test printouts.
123HP Officejet 4655 Wireless Setup for Windows
Follow the steps below to help with the HP Officejet 4655 Wireless Setup for Windows
- On the printer's control panel select 123.hp.com/oj4655 and look for the settings menu.
- On the setting menu, choose the wireless setup wizard menu.
- Continue by clicking on the OK option and move forward with the process.
- Now on the HP Officejet 4655 printer device connect to the desired network connection.
- Key in the credentials for the wireless network connection and follow on-screen instructions and complete HP Officejet 4655 Printer Setup the process.
123 HP Officejet 4655 Wireless Setup for Mac
Read through the simple steps below for a hassle-free HP Officejet 4655 wireless setup for Mac.
- Make sure the Mac computer is connected to a stable network connection.
- On the home screen, choose wireless setup wizard from settings.
- By clicking on next continue with the HP wireless setup process.
- Connect to the desired wireless router from the available router list and key in the relevant details.
- To complete the process follow on-screen instructions, finally, assign a print task to confirm connectivity.
For Printer First time Setup, Driver Download, Wireless Setup and your printer issues.
123 HP Officejet4655 Wifi Setup
Follow the steps below for HP Officejet 4655 Wi-Fi setup
- On the HP Officejet, 4655 printers choose the wireless icon on the printer's panel.
- Locate the Wireless Setup Wizard and select the Ok option.
- Find the network name on the available network list, if it is not available then, enter the new network name and click on the OK option.
- Continue by connecting the HP Officejet to the desired network.
- Finally, download and run the wizard and complete HP Officejet 4655 Wifi Setup process.
123HP Officejet 4655 Wifi Direct Setup
Follow the steps for HP Officejet 4655 Wifi Direct Setup:
- Select the start icon on your computer and move to printer control panel.
- Search for setting icon on printer control panel.
- Select the Wireless Setup Wizard from the setting menu.
- Choose your desired network for your hp 4655 wireless setup printer device.
- Now enter the network password to connect your HP Officejet 4655 printer device with the wireless network.
- After entering the network password, wait for on screen instructions.
- Follow the step wise guidance to complete the Wifi Direct Setup for hp setup 4655 printer device.
How to connect your hp Officejet 4655 wireless printer in Windows 10?
Follow the steps below for a quick and easy HP Officejet 4655 wireless printer setup on windows 10
- Start by turning on the HP Officejet 4655 wireless setup printer and the Windows system.
- Tap on the start menu and type printers in the windows search on the space given on-screen.
- A printer and scanners list will be displayed on the computer. Now on the settings menu go to the control panel on the printer.
- Choose the wireless setup wizard option from the settings menu. Follow the instructions on the screen and connect the HP Officejet 4655 WPS setup printer device to the wireless network.
- Connect the HP Officejet 4655 to a wifi network and add the printer device to the devices option.
How to Add an HPOfficejet 4655 Printer to a Wireless Network
- Ensure that your computer is compatible with the network.
- Now turn on your HP Officejet 4655 printer device.
- Follow the instruction on your computer screen till you reach the HP printer setting section.
- From the setting option navigate through wireless setup wizard option.
- Expand the wireless setup wizard option, which will display the available wireless network.
- Choose your desired network, and type your network password.
- After successful authentication of wireless network, your HP Officejet 4655 printer device will be connected with wireless network.
- Confirm whether your HP Officejet 4655 printer is added to your devices and printer option in your computer.
123 HP Officejet 4655 Wireless – Troubleshooting
123 HP Officejet 4655 Printer does not maintain its Wireless Connection
If you having trouble with the HP Officejet printer maintaining its wireless connection, then follow the simple steps below to help with the issue.
- Download and install the HP print and scan doctor on the device and allow it to locate any network or connection issues.
- Once the print and scan doctor locates an issue, follow on-screen instructions to rectify the error.
- Ensure that the wireless connection is stable and in rage to avoid the wireless connection error.
- Bring the HP Officejet 4655 printer and the computer device close to each other.
- If there is still an error with the wireless connection then change the configuration of the router, it will help the HP Officejet 4655 WPS setup to remain stable.
123 HP Officejet 4655 will not detect wireless network
If your HP Officejet 4655 printer device does not detect wireless network, then consider the below suggestions:
- Try to restart your HP Officejet 4655 printer device and your computer.
- Before you restart your computer make sure to close all the running applications.
- Ensure that your wireless network connection is reliable.
- Move to printer control panel and opt for settings option.
- Choose the hp oj4655 wireless setup wizard form settings drop down menu.
- Provide your wireless network information to which you want to connect your HP Officejet 4655 printer device.
- Follow the guidance on the screen to connect HP Officejet 4655 printer device to desired wireless network.
- Follow the instructions to complete the wizard setup for your hp 4655 printer.


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Ten years after Return of the Jedi, Topps trading cards editor and writer Gary Gerani was tasked once again to meet fan demand for more Star Wars trading cards. Many years before he would create photo cards for a new trilogy of prequels, he would team up with Lucasfilm's Steve Sansweet to showcase Star Wars as interpreted by some of the best artists that contributed to the films or would re-imagine the "Star Wars Galaxy" in their own styles.
The three resulting trading card series have been released in the 2016 addition to Abrams ComicArts successful hardbound series featured here previously at borg.com. Star Wars Galaxy: The Original Topps Trading Card Series includes the works of more than 170 artists in more than 200 card reproductions, plus commentary by Gerani and an afterword by notable poster artist Drew Struzan. Unlike the prior volumes in the series, only the obverse image from the cards, which featured the artwork, is included.
You'll find an incredible array of imagery by a surprising combination of artists, including rare images you will have seen only if you collected the original cards. So you'll find the work of Jack Kirby, Steve Ditko, Ralph McQuarrie, Moebius, Drew Struzan, Dave Dorman, Al Williamson, Howard Chaykin, Mike Grell, John Eaves, Mike Zeck, George Perez, Jim Starlin, Dave Stevens, Walter Simonson, Gene Colan, Rich Buckler, Bill Sienkiewicz, Mark Schultz, P. Craig Russell, Dave Gibbons, Sergio Aragones, Boris Vallejo, Charles Vess, and Gil Kane.
The volume includes the entire run of portraits created for Star Wars Galaxy specifically for the Topps cards by Joseph Smith–the original art was later bought by George Lucas for his personal collection.
But that's not all. A generation of newer talent provided contributions to the series, many whose careers would take off in the years following Star Wars Galaxy, including Mike Mayhew, Jill Thompson, Mike Mignola, Mike Oeming, Joe Quesada, Jae Lee, Mark Chiarello, J. Scott Campbell, and Greg Capullo.
A chrome book jacket mimics the unique Topps packaging, and four bonus trading cards are included with the book.
It's a nostalgic look at a broad selection of art styles and favorite Star Wars subjects. Pick up a copy of Star Wars Galaxy: The Original Topps Trading Card Series now here at Amazon.com.
C.J. Bunce


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This week's Secret Ingredient for Friday Foodie Fix is Onions! As you can tell by looking at my Ingredients listing, onions is the largest word which means it's in a lot of my recipes. It's a go to ingredient which I go to way too much. There are so many great onions. I love the spring onions, leeks, green onions, shallots, red onions, Spanish onions, sweet onions, white onions and more. There are over 300 varieties of onions but most are sold by types instead of names. I just listed a combination of both names and types.
When buying an onion it should feel firm and should smell mild unpeeled. Store them in a cool, dry and well-ventilated place that is also dark. Also, don't store them near potatoes. Potatoes give off gas and moisture and will make onions spoil more rapidly. Oh, now you get the problem in your refrigerator drawer.
I would love for you to share your recipes with onions here using Mr. Linky. To check out mine just click on the word onion in the Ingredient listing on the side column. This is where you can find the ingredients I use most and which recipes they are in. Just in case you have extra whatever and you're looking for a recipe to use it.
If you need the rule of how to participate in this blog carnival check out Friday Foodie Fix at the top of this page for all the details.
Next week's Secret Ingredient is …………….. Tomatoes!


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Betrothal in a Monastery (1940-41)
Plays: 9237
opera in four acts
Don Jerome! Don Jerome! (excerpt)
Duration: 01 mins 00 secs
Anna Netrebko / Marianna Tarassova / Alexander Gergalov / Evgeny Akimov / Nikolai Gassiev / Kirov Opera Chorus and Orchestra / Valery Gergiev
(p) and © 1998 Philips Classics Productions
Philips 462 107-2
To purchase this CD from Amazon, click here now.
To purchase this CD from www.iclassics.com click here now.
Guests: It's so pleasant, so pleasant to dine,
to drink, to dance and laugh in this house, eh!
Our Don Jerome is the kind of host that anyone
would feel contented,
so contented in his house, eh!
Louisa/Clara: As two young mistresses of the house, we shall try
to receive you first.
Antonio: Only recently you chased me off not so affectionately
From under your window with a shoe.
Don Jerome: Only recently I chased you off not so affectionately
from under my window with a shoe.
Don Ferdinand: Even though I chased you off,
with all my soul I'm glad
that you are now a son and brother.
Louisa/Clara: Ah, it's so dangerous to sing serenades.
Antonio: I agree, it was late, I made a noise
and you were fast asleep.
Don Jerome: Indeed, it was late, and you made such noise,
while I was dreaming my third dream.
Louisa/Clara: If you go singing,
then do it quietly.
Don Ferdinand/Antonio: You can sleep calmly now
and smile like a sleeping child.
Now we'll see to it
that no more serenades are sung under your windows.
Louisa: Now he's your son. It's time
to forgtet the shouting and the guitars
and swallow a glass of sparkling wine.
Clara: So now it's all over.
Now we'll see to it that no serenades
are sung under our windows.
Don Jerome: So now you are my son.
All is forgotten: the shouting, the noise,
and we shall drink a drop of wine together.
Guests: Tinkle, tinkle, tinkle!
It's so pleasant, so pleasant to dine, to drink, to dance
and laugh in this house, eh!
Our Don Jerome is the kind of host that anyone would feel contented,
so contented in his house, eh!
Louisa/Clara/Antonio/Don Ferdinand: Don Jerome is not such an awesome cavalier,
even though he tried to frighten us to death.
It's all because Don Jerome is much kinder
than he wants to appear!
Guests: Some wine...
Louisa/Clara/Antonio/Don Ferdinand/Don Jerome: Serve the wine...
Guests: Strong wine...
Louisa/Clara/Antonio/Don Ferdinand/Don Jerome: Over here...
Guests: Give us some...
Louisa/Clara/Antonio/Don Ferdinand/Don Jerome: Some wine. Your health!
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text:
The buzz in the tech industry is all about Apple's upcoming announcement on January 27 about the Apple Tablet, so many of us are dying to get our hands on. Apple will not confirm that the announcement is going to be the release of the tablet, but many in the consumer electronics industry are pretty sure that will be the announcement. Check back for more on the Apple announcement.
Stay up-to-date about all the latest consumer electronics technology right here on the Abt Blog.
–Kelly B.