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The Food and Drug Administration approved a new "smart bomb" drug on Friday that can help women with one of the most hard-to-cure types of breast cancer.
The new drug added several months of life to women with a type of breast cancer called HER2-positive breast cancer, whose tumors had spread despite treatment. While it wasn't a cure, it did add some healthy months of life to patients whose outlook was otherwise hopeless.
The drug is called Kadcyla, and it works in an unusual way. It combines an older drug, Herceptin, with a highly toxic type of chemotherapy called DM1. The Herceptin hones in on the tumor cells, which absorb the package and are then destroyed by the DM1, which is too strong to deliver like standard chemotherapy. It's a member of a new class of drugs called antibody-drug conjugates or ADCs.
"Kadcyla delivers the drug to the cancer site to shrink the tumor, slow disease progression and prolong survival," Dr. Richard Pazdur, director of the FDA's office of hematology and oncology products, said in a statement.
In a trial of 991 women with advanced HER2 breast cancer, those who got Kadcyla lived on average 5.8 months longer than those getting more standard chemotherapy, researchers reported last year in the New England Journal of Medicine. It meant about 2 ½ years of life after diagnosis, compared to two years for those on standard therapy.
"Only a few studies in metastatic breast cancer have shown an improvement in overall survival. It's tough to do," Dr. Sunil Verma of the Sunnybrook Odette Cancer Centre in Toronto, who led the study, said in a statement on the National Cancer Institute's website.
Genentech, which makes the drug, is now focusing on the ADC formula. The hope is it can cause fewer side-effects than ordinary chemo, which can affect healthy tissue. Herceptin is a synthetic immune system protein or monoclonal antibody called trastuzumab.
"We currently have more than 25 antibody-drug conjugates in our pipeline and hope this promising approach will help us deliver more medicines to fight other cancers in the future," Dr. Hal Barron, the company's chief medical officer, said in a statement.
It's not cheap. A nearly 10-month course of therapy costs $94,000, Genentech says.
Genentech promised the FDA it would help patients pay for it. "People who do not have health insurance, or who have reached the lifetime limit set by their insurance company, might qualify to receive Kadcyla free of charge," the company said in a statement. Herceptin alone costs more than $4,000 a month.
The drug is not without side-effects. It can damage the heart, liver and lungs and pregnant women can't take it.
Breast cancer is the biggest cancer killer of women, after lung cancer. It's diagnosed in about 235,000 U.S. men and women every year and kills 40,000, according to the American Cancer Society.
About 20 percent of cases are known as HER2-positive breast cancer. That means the tumor cells make extra amounts of a protein called human epidermal growth factor receptor 2. It makes for a very aggressive type of cancer and it's more likely to come back after treatment than other breast cancers.
Women newly diagnosed with HER2 breast cancer should still be treated first with Herceptin alone for a year, the National Cancer Institute says. But doctors may test the new drug in some volunteers to see if it works better.
Related links:
Smart bomb therapy helps breast cancer patients
Breast-conserving surgery may save lives

subset: commoncrawl


text: For weeks now, the Ankara government has been saying that the number of 100,000 Syrian refugees in Turkey was a "psychological limit" – the point at which the border crossings would be closed. This week, the Turkish Disaster Management Agency, Afad, announced that there are now 100,363 Syrians at 14 camps along the border between Turkey and Syria, increasing speculation that no more refugees would be allowed in. Despite the threats, the influx shows no sign of slowing down."The 100,000 figure was truly a threshold for us, but we always said it may exceed 100,000," Prime Minister Recep Tayyip Erdogan told reporters. "We are now currently working on this issue."The actual figure is even higher. In addition to those living in the government facilities, there are an estimated 70,000 Syrians who have fled the fighting but choose to rent apartments rather than live in refugee camps. In the camps themselves conditions are reasonable.console.log("BODY2. CatId is:"+catID);if(catID==120){console.log("BODY. YES for anyclip script");var script = document.createElement('script'); script.src = 'https://player.anyclip.com/anyclip-widget/lre-widget/prod/v1/src/lre.js'; script.setAttribute('pubname','jpostcom'); script.setAttribute('widgetname','0011r00001lcD1i_12258'); document.getElementsByClassName('divAnyClip')[0].appendChild(script);}else{console.log("BODY. YES for vidazoo script"); var script = document.createElement('script'); script.src = 'https://static.vidazoo.com/basev/vwpt.js'; script.setAttribute('data-widget-id','60fd6becf6393400049e6535'); document.getElementsByClassName('divVidazoo')[0].appendChild(script); } "The Turks have done an extremely good and professional job of setting up the camps," Gerry Simpson, the refugee coordinator for Human Rights Watch told The Media Line. "Refugees are allowed to leave the camps for days or even weeks so they're relatively free to move which is more than can be said in Iraq and Jordan where the authorities are refusing the refugees the right to leave the camps."The weather is already turning cold in Turkey. Simpson says officials are preparing for the change in temperature, with extra blankets and heaters for the refugees' tents. Where Human Rights Watch is concerned, he says, is the situation on the Syrian side of the border, where an estimated 15,000 people fleeing the fighting are waiting to enter Turkey. At least two border crossings have already been closed."We are concerned about the thousands and soon to be tens of thousands who are stuck on the Turkish border as a result of the border closure," he said. "In some of these places people are living under trees, in makeshift tents, or in schools where they are out in the open. They have little access to assistance. As winter approaches, it will become more urgent for Turkey to stop playing games and open the border crossings for Syrians fleeing violence."Tensions have increased as the once warm relations between Syria and Turkey have grown colder, and the two countries seem almost on the brink of war. This week, Turkey banned all Syrian flights from its airspace and ordered a plane to land after fears it was carrying weapons to Syria. But most Turkish citizens differentiate between the government of Syrian President Bashar Assad, which they see as the enemy, and the Turkish refugees fleeing the violence."I don't think there's a real problem with the refugees --- these people will eventually go back to Syria," Faruk Yalvach, a professor of political science at Middle East Technical University told The Media Line. "If eventually Assad goes, then Turkey will have a good position with all of these refugees thanking Turkey for taking care of [them]."The total number of refugees is over 300,000 according to the United Nations. Besides the ones in Turkey, some 210,000 are in Jordan, straining that country's resources. In Turkey, too, officials say the international community must provide more money for the refugees.For many years there have been close relationships between families living on both sides of the Turkish-Syrian border.But as the refugee flow continues, attitudes are likely to change. Turkish officials say they are willing to shoulder part of the burden of dealing with the influx from Syria, but they cannot be solely responsible. Now that the figure of 100,000 has been reached, it is likely that Turkish officials will move to stem the flow of refugees."We understand the problems and we want to help," Professor Yalvach said. "But it has to end somewhere."For more stories from The Media Line go to www.themedialine.org


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Sypher's former lawyer Dana Kolter testified that they had an "intimate relationship" before he threatened to sue Rick Pitino as part of her extortion plan. Jurors were then shown photographs of Sypher and Kolter engaging in oral sex.
Sypher's got a way about her of meeting men in the strangest places. With Tim Sypher, it was at the abortion clinic. With Lester Goetzinger, it was when he came to her house to install the gas. And with Dana Kolter, it was when he pulled out of a parking spot she wanted.
That's what jurors heard in Kolter's testimony Friday, plus much much more. Kolter, a married man, started an affair with Sypher in 2006, even as she pursued divorce proceedings against Pitino assistant Tim Sypher — with Kolter as her divorce lawyer.
On Valentine's Day 2008, she came to his office in "an outfit appropriate" for that holiday and performed oral sex on him, during which he said she agreed to be photographed, he testified.
These are the first three photos entered as evidence:
The last photo, you'll have to use your imagination. Here's an aide:
Is that your abdomen?" Kuhn asked Kolter, showing one of the pictures to the jury.
"Unfortunately, yes," Kolter said.
Karen Sypher sat silently at the defense table as the pictures were displayed, showing no sign of emotion.
Ed. note: This is something we'll gladly reach into the burlap sack of scuzz money to acquire: $2,000 to anyone who can produce the "abdomen" photo of Karen Sypher performing oral sex on her former lawyer in his office. Anonymity guaranteed.


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Please visit our Open House at 1081 SCANTLINGS in Vancouver.
Open House on Saturday, July 23, 2016 2:00PM - 4:00PM
Come discover one of Vancouver's hidden gems where every day is a holiday! This sophisticated residence offers house-size rooms with gleaming hardwoods throughout much of the main level. A spacious kitchen opens into the living room where you can relax by the fire in winter and enjoy the cherry blossoms in spring. Enjoy a main floor master with generous closets and updated 2-piece ensuite in addition to a large second bedroom currently being used as a sitting room, updated bathroom with jetted tub and third bedroom/den upstairs. The crowning feature is a 685sqft roof-top deck that has water and city views. Perfect for parties, gardening or just relaxing with a cold beverage. Make this rainscreened home that is steps to the seawall, Granville Island and more your every day vacation!


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Oval Cut Moissanite Engagement Ring
Oval Cut Moissanite Engagement Ring
Sale Sold out
Regular price $1,800.00 USD
Regular priceUnit price per
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Modern and bold, ask for her hand with this amazing Moissanite and diamond engagement ring. Beautifully crafted in 14k gold, this ring showcases a magnificent 9x7 mm oval cut Moissanite, 2.25 carat diamond equivalent, standing tall in the traditional six-prong setting. Accompanying the center stone are 0.35ctw of round brilliant natural diamonds E-F Color and VS2 clarity. So elegant it needs no further accompaniment, this ring is finished with a bright polished shine.With a focus on sustainability, this style is crafted in recycled and refined gold. This way, you receive the same quality gold as you would get with newly mined metals, without the impacts mining has on our fragile ecosystem. ~This ring is made to order and is eligible for a one-time complimentary resizing. It is not eligible for return or cancellation~ **NOTE: please allow 12 business days for this ring to be handcrafted prior to shipping**


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Writes our submitter from the UK: "It seems that student living brings out the best in passive aggressive note-writers."
related: EAT ME!
Writes our submitter from the UK: "It seems that student living brings out the best in passive aggressive note-writers."
related: EAT ME!
→ 98 CommentsFILED UNDER: college life · food · smartass
Isaac prefaces this by saying, "I feel bad for the person who posted this screed. I really do."
But — and isn't there always a but? — he adds: "The university library here has a HUGE laptop and gadget-theft problem, and there are signs everywhere warning people not to leave their stuff unattended. This guy left a $2000+ shiny Apple laptop just sitting on a table, with all of his super-sentimental irreplaceable pictures on it, and just walked away. And then expected nothing to happen. Really?"
related: Which is a more despicable crime?
→ 135 CommentsFILED UNDER: college life · guilt trip · New Jersey · purple prose · stealing
What's tackier than a pimp cup crusted in rhinestones? How bout a pimp cup crusted in last weekend's purple drank?
(Thanks, CharChar!)
related: That's punny
→ 27 CommentsFILED UNDER: dishes · roommates
Mothers-in-law. 'Nuff said.
related: Nobody does guilt trips quite like Grandma
extra credit: sixwordmemoirs.com
→ 48 CommentsFILED UNDER: Facebook · family · Grandma · guilt trip
Writes Patrick in Wisconsin: "A member of our office staff prefers a lighter blend, while the rest of us tech guys prefer a cup of coffee that will actually wake us up."
After the original laminated note spurred this tempest in a coffee pot, Patrick says that Ms. "Three Scoops" upped the ante by bringing in a second coffeemaker for her own personal use. The notes, however, remain.
related: Coffee-brewing for engineers
→ 104 CommentsFILED UNDER: a matter of taste · coffee · office · saga · Starbucks
Writes Jack in Seattle: "A friend of ours is a professional tile setter and general handyman. Sometimes he stays over and parks his work van on our block. We found this note on his windshield one morning after Sunday brunch. It's so typically 'Seattle' it's hard to be offended."
Meanwhile, Charon noticed that this van-owner in Couer d'Alene, Idaho did get offended, "apparently because he owns a creepy van and people pointed out that it was creepy."
P.S. Van owner: Maybe "I own a home next to the school" wasn't the best way to get your point across here?
related: I don't know you, and this is crazy…but your boyfriend's hot, and your parking's lazy.
extra credit: the 10 creepiest vans [jalopnik.com]
→ 67 CommentsFILED UNDER: Idaho · kinda creepy · parking · Seattle · smiley
And Dani in Texas…thanks for sharing?
related: A nasty twist on "Man Bites Dog"
extra credit: Nance Bodean's Guide to Power Walking [youtube]
→ 56 CommentsFILED UNDER: p.s. · shit · Texas
Writes our submitter, Amy: "In going through my late great-grandmother's memorabilia trunk, I saw that she apparently kept a 'thank you' letter I wrote her when I was eight years old." (Said Amy's mother, of the discovery: "I clearly did not supervise the writing of this note.")
related: Grandma saves granddaughter the trouble; writes thank you note to herself
→ 28 CommentsFILED UNDER: family · kids · thanks (but not really)
So, which jumble o' jargon would you rip off the wall first?
Exhibit A?
or Exhibit B?
Coincidentally, both of these notes come to us from Colorado, apparently the least creative state in the union.
Go ahead and post those speculative explanations regarding The Centennial State's staggering dearth of originality in the comments below. Then we'll circle back to brainstorm some synergistic solutions. ("The Centennial State?" Really? It's like you're not even trying, Colorado!)
related: The rhyme that must be flushed
→ 55 CommentsFILED UNDER: Colorado · office · toilet · Your mother doesn't...
Writes Jean in Minneapolis: "Apparently some cool college girls decided to leave their mark on the wall of this pizza joint, just out of eye shot from the kitchen. The entire hallway is sprinkled with lipstick kisses."
related: Do not kiss on someone else's kiss
→ 32 CommentsFILED UNDER: Minneapolis/St. Paul · restaurant · so this is a thing? · that's unsanitary


text: This luxury living space is located in Paddington, Sydney, Australia. It's contemporary entertaining dream oasis that offers tranquility and privacy everybody want nowadays. It features stunning interiors and magical outdoor areas. The soaring central garden and loggia terraces add sheer beauty to the various levels, while the roof garden and multiple living areas give new meaning to all-year-round indoor outdoor entertaining. The house also features a 6-car garage with internal access, a fully equipped kitchen, home office and library areas, several powder rooms, living and TV areas, a plant room, an amazing wine cellar, and many other areas that every luxury house should have. Innovative sliding door-wall systems, upholstered walls, heated floors, security systems and other contemporary solutions were used in the construction. By the way, the house is for sale.


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Private Equity Is Becoming a Public ProblemA few weeks ago, a top official at the Securities and Exchange Commission reported on what he called a "remarkable" amount of potentially illegal behavior in the private equity industry -- aka the industry that buys up, changes and sells off smaller companies.
A few weeks ago, a top official at the Securities and Exchange Commission reported on what he called a "remarkable" amount of potentially illegal behavior in the private equity industry — aka the industry that buys up, changes and sells off smaller companies.
In its evaluation of private equity firms, the SEC official declared that half of all the reviews discovered "violations of law or material weaknesses in controls." The announcement followed an earlier Bloomberg News report on how the agency now believes "a majority of private equity firms inflate fees and expenses charged to companies in which they hold stakes."
At first glance, many probably dismiss this news as just an example of plutocrats bilking plutocrats. But that interpretation ignores how such malfeasance affects the wider economy.
One way to understand that is through the simmering debate over pension obligations in states and cities across the country.
Citing data from the National Association of State Retirement Administrators, Al-Jazeera America recently reported that the average amount of pension dollars devoted to private equity and other so-called "alternative investments" "has more than tripled over the last 12 years, growing from 7 percent to around 22 percent today." With public pensions now reporting $3 trillion in total assets, that's up to $660 billion of public money subject to the rapacious fees being exposed by the SEC. Those fees are paid through a combination of tax increases and pension benefit cuts.
Private equity shenanigans can also hurt the middle class by encouraging looting. For instance, as Crain's New York recently reported, in the last decade, private equity firms have collected $2 billion in so-called "transaction fees," which the business publication says "are bonuses the firms take for conducting their business of buying, managing and selling companies." This scheme has been called the "crack cocaine of the private equity industry."
As just one example of how it works, the New York Times recently examined a merger of two orthopedic implant manufacturers and how that merger resulted in a Wall Street jackpot. Indeed, according to the Times, the financial firms involved in the deal ended up extracted "a 20 percent share of gains from the sale, as well as management fees of 1.5 percent to 2 percent charged to investors" and "a share in an estimated $30 million in 'monitoring fees.'" The Times noted that "this deal will be a gift that keeps giving" to the private equity firms involved because "they will be paid millions more in fees for work that they are never going to do."
In other words, millions of dollars are taken out of companies creating tangible economic value and jobs. The money instead is sent to the speculators.
The good news, of course, is that we know how to curtail some of the worst effects of private equity's expansion. For one thing, the SEC can follow up its evaluation with fines and prosecutions. Additionally, states can pass laws mandating at least some modicum of transparency in their pension funds' dealings with the private equity industry. And, as Eileen Appelbaum of the Center for Economic and Policy Research has written, the tax code can be changed to make sure that the fees claimed by private equity managers are no longer treated as capital gains and therefore taxed at a discounted rate.
The trouble is that these straightforward solutions all require political will, and American politics remain dominated by Wall Street money. The question, then, is simple: How much more looting has to happen before that cash can no longer buy inaction?
David Sirota is a staff writer at PandoDaily and the best-selling author of the books "Hostile Takeover," "The Uprising" and "Back to Our Future." Email him at [email protected], follow him on Twitter @davidsirota or visit his website at www.davidsirota.com.
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The United States officially went to war in Iraq 10 years ago, on March 19, 2003. But in one small sense, the war can be said to have begun in 1989. That was the year a London-based Iraqi architect named Kanan Makiya published a book called "Republic of Fear."
Written under the pseudonym Samir al-Khalil, the book offered a devastating inside analysis of Saddam Hussein's regime, depicting it as a Middle Eastern version of the totalitarian states that emerged in Europe in the 1920s. Makiya, the son of a prominent Iraqi architect, was living in the West after having worked for his father's firm and receiving a PhD in architecture from MIT. When Hussein invaded Kuwait the next year and the United States went to war, "Republic of Fear" became a surprise bestseller; its author went on to become a professor of Islamic and Middle Eastern studies at Brandeis University. And when George W. Bush's administration built the case for the second Iraqi war starting in 2001, it turned to Makiya's book for support once again.
It is difficult to overstate Makiya's intellectual and moral influence on those who forged our position on Iraq over two decades. He appeared frequently in the media as the unofficial spokesman for the Iraqi exile community, a human symbol of what might be possible in a liberated Iraq. He met with Bush and Vice President Dick Cheney in the run-up to the war and worked with Iraqi exile groups to build a post-Hussein Iraq. He was the protagonist of "The Assassins' Gate," journalist George Packer's book on the planning and execution of the Iraq war. As former New Republic editor Peter Beinart wrote, looking back at why he supported the war: "For myself, perhaps the most honest reply is this: because Kanan Makiya did."
Today, the landscape is radically different. Iraq as a polity is "a failure," Makiya admits from London, where he is on sabbatical, working on a book about the failures of the Iraqi elite. Today, Makiya receives no White House invitations; even by 2007, Beinart wrote of Makiya, "I haven't seen him, or read anything he's said or written, in several years." Beinart's mournful but devastating assessment—that Makiya was too idealistic, too sure of American intentions and Iraqi potential—has come to be the standard view of him among former war supporters.
Makiya himself has backed away from promises of Iraqi harmony. Instead, he spends his time on the nonprofit organization he founded, The Iraq Memory Foundation, which compiles documents, interviews, and artifacts chronicling the horrors of Hussein's regime. He is grappling with the legacy of his writings and public work, which many people see as profoundly damaging—yet he still stands by his central belief that Iraq was a genuinely horrifying regime that did need to be overthrown. "What has happened in Iraq is primarily the fault of Iraqis, not of Americans," he says. Of his book, he says: "I do not regret writing it in the slightest.....I don't think the question is: How were a writer's ideas used by others? It is: Did they accurately describe things?"
The Iraq that Makiya described in "Republic of Fear" was unlike anything else in the Middle East. Instead of being a traditional autocracy like Saudi Arabia or Jordan, Iraq was a totalitarian state—an Arab equivalent of Mussolini's Italy and Stalin's Soviet Union, under the ruthless thumb of Hussein's Ba'ath Party. Secret police, a cult of
personality based on an all-powerful leader, a society based around fear—all were present in Iraq. Makiya described life there as an almost existential horror. "In Iraq, the public has lost all sense of self; it exists only in the form artificially imparted to it by 'its' regime," he wrote.
"Republic of Fear" was released by the University of California Press in the spring of 1989 and was little noticed at first, selling about a thousand copies in its first year. But when Hussein invaded Kuwait on Aug. 2, 1990, it became a bestseller in the United States and Britain, and Makiya suddenly became a public figure. "Republic of Fear" offered a moral argument for the war; when President George H.W. Bush likened Hussein to Hitler, he was reading straight from Makiya's script. "Makiya's trenchant account was of the moment," says Augustus Richard Norton, a Middle East expert at Boston University.
In his book, Makiya didn't call for outside powers to liberate Iraq—indeed, he barely mentioned the Western world at all. But things changed once the United States initiated war. "I was the first person to argue, in 1991—it was a different story in 2003—that the US should topple Hussein," Makiya says now.
With Hussein still in power through the 1990s, Makiya began to be referred to as an Iraqi version of Alexander Solzhenitsyn, the Soviet dissident who chronicled his government's atrocities. In 1993 he published another book, "Cruelty and Silence," which castigated Arab intellectuals for ignoring the evils of Hussein and for blaming the Middle East's failings on the United States. "I became for the US media a kind of lightning rod for the Iraqi opposition," he says. "It was a simplification and a reduction, but I was not alone—it was the same thing with Edward Said, where he was assumed to be some kind of spokesman for the Palestinians."
When a US invasion became a concrete prospect after the 9/11 attacks, Makiya was there to offer encouragement. He formed an alliance with the Iraqi banker Ahmad Chalabi, and the two became the most influential Iraqis living in the United States.
Makiya provided a "useful, supportive voice" to the most hawkish elements of the Bush administration—"people like Dick Cheney, Paul Wolfowitz, Donald Rumsfeld, and Douglas Feith," recalls Lawrence Wilkerson, Colin Powell's
then-chief of staff. "Not necessarily a witting one, but a useful one." In January 2003, right before the invasion, Makiya met with George W. Bush, Cheney, and Condoleezza Rice at the White House to discuss postwar Iraq. Makiya told Bush that Americans would be greeted as liberators. At a press conference he was even more effusive, saying, "Even if the president has to go into this enterprise alone, which of course is not the case, the judgment of the world, of history will overwhelm his critics the day after."
Makiya was even more influential in moving liberals and Democrats toward support for an invasion on humanitarian concerns. "Makiya's genuine commitment to human rights and liberal democracy appealed to liberal hawks like me, and the fact that he supported military action relieved—in retrospect wrongly—some of my concerns about a nationalist backlash against a US invasion," says Beinart, who as editor of The New Republic endorsed the war.
In the end, of course, nothing like that vision took place. Chalabi's claims to represent Iraqi opinion turned out to be as illegitimate as his business dealings. An easy military victory was followed by a disastrous occupation, a long sectarian war, and a deadly insurgency against the United States that has killed nearly 4,500 Americans and more than 110,000 Iraqis. Ten years after the war began, Hussein is long gone, but Iraq is in shambles, without a stable government.
Though Makiya thinks the United States bungled the initial management of the occupation—"The first years, what I call the Paul Bremer years, were just one mistake after another"—he insists the primary culpability does not lie not with the United States. "The Iraqi leadership proved itself capricious, greedy, selfish—it was a failure on the part of the elites," he says. The book he has been working on for more than five years is about the "great historic betrayal of Iraq by this new class of intellectuals created by the war."
Despite all this, Makiya does not regret pressing the case for war. "I said at the time and still believe that if there's a 5 percent chance of Iraq becoming a democracy, we have to do it," he says. "Under Saddam it was zero percent." From the Iraqi perspective, then, the war was the right thing to do. But from an American perspective? "I always said that, understood for US interests"—he hesitates—"I could understand for someone from the Midwest, why asking their sons to die for something that is not even a democracy isn't worth it."
In fact
, Makiya rarely, if ever, publicly said the war would be detrimental to the United States. When he told Bush and Cheney that Iraqis would greet Americans with "sweets and flowers," he was suggesting the cost of the war would be slight and the benefits tremendous. Makiya's stubbornness—he told The New York Times in 2007 that "people shouldn't feel the need to apologize"—enrages his detractors. They describe Makiya variously as a tool of the Bush administration and uncaring about the
suffering the Iraq war has caused. "The point is he doesn't want to admit he's wrong because he doesn't want to live in a world in which he wasn't right," Samantha Power, until recently a senior White House staffer, told a reporter at The American Prospect in 2007. Virtually everything written and said about Kanan Makiya since the Iraqi insurgency emerged has been about just how Makiya could have gotten it so wrong.
Others are more charitable. "Kanan paid a huge personal price for the catastrophe that was the American invasion of Iraq, but no one should forget how terrible Saddam's tyranny was and how important Kanan's role was in denouncing that tyranny and mobilizing opinion against it," says Michael Ignatieff, a Canadian politician and Harvard Kennedy School of Government professor. Ignatieff was himself a prominent war supporter, advocating intervention as a New York Times Magazine writer and the director of the Carr Center for Human Rights Policy at Harvard from 2000 to 2005.
George Packer, whose book portrayed Makiya as well intentioned but a dreamer, sees him today as an honorable man whose mistakes are well chronicled. "Kanan justifiably was criticized for thinking the liberalization and democratization of Iraq would come quickly and easily, but those causes are not going away, and I think his reputation will only grow in stature over time," says Packer. "In 30 years, Kanan Makiya will be seen as a visionary and champion of democracy, I think, even if the fact of the invasion itself and the terrible aftermath set those causes back."
At the very least, Makiya is an unusual figure in history: the author of a book still seen as accurate and astute, but whose repercussions have been catastrophic for many of the people it was supposed to help. The nearest modern parallel, perhaps, is George Kennan, the diplomat whose pseudonymous 1947 article about the Soviet Union became the source for the American doctrine of "containment." Over the following decades Kennan's work was used to justify military intervention everywhere from Vietnam to Cuba, often with bloody and harmful results. In his memoirs years later, Kennan rued his influence: "I felt like one who has inadvertently loosened a large boulder from the top of a cliff and now helplessly witnesses its path of destruction in the valley below, shuddering and wincing at each successive glimpse of disaster."
Kennan backed off of his original analysis, saying he had been unduly alarmist about the Soviet Union. Makiya has no such misgivings, at least about "Republic of Fear." "I do not regret writing it in the slightest," he says. The mistake he made, he says, was in having faith in the possibilities of Iraqi elites to rise above sectarianism. "I wouldn't change my positions, because I feel the war was the right thing to do, but I made real errors of judgment in what I thought Iraqi elites were capable of," he says.
Makiya now says he believes the war contributed to the Arab Spring. "People on the ground in Egypt and Syria don't want to admit that there was a connection, but something fundamental happened as a result of the war—a culture and an ethos changed." (Indeed, they will not admit it. When Wael Ghonim, the Egyptian Google executive whose Facebook page helped spark the Egyptian uprising, was questioned about the Iraq's War's contributions, he said it contributed "not at all.")
But "Republic of Fear"'s ultimate effects are beside the point for Makiya. What matters is that it accurately described the unique viciousness of Saddam Hussein's Iraq. "A book is like a baby—you give birth to it and what someone makes of it is something entirely different," he says. "Books are not written to be used by others."
Jordan Michael Smith is a contributing writer at Salon and the Christian Science Monitor.


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Ray Stedman - March 11, 1989
Looking for a Few Good Men
Scripture References: Nehemiah 13:1-14
From Series: "Nehemiah"
Ezra, Nehemiah and Zechariah were written after the return of the Jews from the Babylonian captivity. Nehemiah tells us about the rebuilding of the walls of Jerusalem in the midst of variegated and ongoing opposition. "But Nehemiah did more than rebuild a wall, as we will learn. This book is also the story of the restoring of a people from ruin and despair to a new walk with God. Jerusalem is not only an historic city which has for centuries been the center of the life of the nation of Israel (and, in fact, the center of the biblical record), it is also a symbolic city. Jerusalem is also used in a pictorial sense throughout the Scriptures. What it pictures is the place where God desires to dwell. When the city was first designated to King David as the place where God wanted him to build the temple, he was told that this was the place where God would dwell among his people. Jerusalem therefore, throughout the Old and New Testament, has pictured the place where God seeks to dwell. However, it is only a picture---it is not the actual place where God dwells for according to the New Testament man is to be the dwelling place of God. God seeks to dwell in the human spirit. That is the great secret that humanity has largely lost today but which New Testament Christianity seeks to restore. The apostle Paul's great statement in the letter to the Colossians is, 'Christ in you, the hope of glory.' This is God's provision and desire for man. Jerusalem in ruins, therefore, is a picture of a life that has lost its defenses against attack and lies open to repeated hurt and misery. If you are at all acquainted with the world in which we live today, you will know that every time you turn your television on you are exposed to the hurt and misery of people whose walls have been broken down. Jerusalem in ruins is a vivid picture of their danger and despair. The book of Nehemiah depicts the way of recovery from breakdown and ruin to a condition of peace, security, restored order, and usefulness."


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The CEMSE division at KAUST is looking for people from Saudi Arabia and around the world who want to create impact beyond their own achievements. We look for "people of the world" who will uphold our values of Achievement, Passion, Inspiration, Citizenship, Diversity, Integrity and Openness.
Join KAUST to be part of discoveries that address global challenges in five key areas: food, water, energy, environment, and digital. To contribute to science and innovation and become part of a uniquely international community where you and your family will thrive.
Faculty Positions 2024
The Computer, Electrical, and Mathematical Sciences and Engineering Division at King Abdullah University of Science and Technology (KAUST) invites applications for faculty positions in Applied Analysis, Partial Differential Equations, Applied probability, and Numerical Analysis, Mathematical Foundations of Data Science, Scientific Computing, Optimization, Applied Geometry, and Related Fields at any level (Assistant, Associate, or Full Professor), beginning in the Fall of 2022. Candidates applying for a position of Assistant Professor should have an excellent potential for high-impact research. Candidates applying for Associate and Full Professor positions should have a distinguished track record in research and a strong commitment to service, mentoring, teaching at the graduate level, and making an impact in interdisciplinary research. Candidates working on the interface of KAUST initiatives, including artificial intelligence, climate and livability, resilient computing and cybersecurity, and smart health, are encouraged.
Candidates must have a doctoral degree in Mathematics or other relevant fields with publications in top journals and subject-matter journals/conferences. Moreover, experience in interdisciplinary research and a strong publication record commensurate with the level of the post he/she applies for are expected. The evidence of a track record in successfully attracting external funding and independent research for senior positions is essential. Women candidates are especially encouraged to apply.Apply here
The Computer Science program in the Computer, Electrical and Mathematical Sciences and Engineering Division (https://cemse.kaust.edu.sa) at King Abdullah University of Science and Technology (KAUST) invites applications for multiple faculty positions at all levels (Full, Associate, and Assistant Professor). The CS program (http://cs.kaust.edu.sa) contributes to create computational infrastructure and developing and applying computational methods to a variety of areas, spanning all aspects of knowledge extraction from big data to achieve economic prosperity and improve the quality of life. All relevant research areas of Computer Science will be considered, including but not limited to Artificial Intelligence (broadly scoped, including Machine Learning, Robotics, Data Mining, NLP, etc.), Computer Systems and Networking, Resiliency and Security, High-Performance Computing and Computational Biosciences.
High priority will be given to the overall originality and promise of the candidate's work rather than the candidate's sub-area of specialization. Applicants on the interface of KAUST strategic initiatives, including artificial intelligence, climate and livability, resilient computing and cybersecurity, and smart health, are encouraged. An earned PhD in Computer Science, Computer Engineering, Electrical Engineering, Mathematics, or a related field, and a strong publication record in top-tier conferences and journals, are required. Senior candidates must have demonstrated strong leadership in the field. Women are strongly encouraged to apply. A successful candidate will be expected to teach courses at the graduate level and to build and lead a research group of postdoctoral fellows and graduate students. Faculty members enjoy secure research funding from KAUST and have opportunities for additional funding through several KAUST provided sources and through industry collaborations.Apply here
The Electrical and Computer Engineering (ECE) Program in the Computer, Electrical, and Mathematical Sciences and Engineering (CEMSE) Division at the King Abdullah University of Science and Technology (KAUST) invites applications for faculty positions at the rank of Assistant Professor (exceptional candidates at the Associate Professor level may be considered).
Candidates in the following areas of Electrical and Computer Engineering are strongly encouraged to apply:
- Analog integrated circuits, low-power and high-precision interface circuits, telecommunication and RF circuits, hardware for Machine Learning and AI, data converters and EDA, and edge computing. Applications in harsh environments and/or power circuits are particularly desirable
- Power electronics, power systems, energy storage systems, electric automotive systems, smart grid technologies, high-efficiency alternative and renewable energy technologies to assure secure access to energy resources while addressing climate change concerns.
- Embedded systems, fault-tolerant computing, hardware-friendly machine learning, low-power computing to enhance safety, efficiency and accessibility, in-vehicle computing, medical and wearable devices, modern cities, and smart industries.
- Robotic and autonomous systems and their applications in areas like (among others) infrastructure monitoring, underwater exploration, smart manufacturing, precision agriculture, and health care.
Candidates with portfolios that align with Saudi Arabia's national priorities for research, development, and innovation (RDI), namely, Health and Wellness, Sustainability and Essential Needs, Energy and Industrials, and Economies of the Future will be given the utmost priority (see also https://www.rdia.gov.sa/index.en.html).Apply here
The current challenges that confront the statistical data sciences deal with the need to efficiently process massive data build powerful statistical models, and develop efficient computational tools. There are opportunities to develop impactful research that can address substantive inferential and forecasting problems on a wide array of complex processes including biological, social, physical, epidemiological, climatological and environmental.
The Statistics Program (https://cemse.kaust.edu.sa/stat) at KAUST aims to contribute to statistical data science by developing modern approaches for conducting rigorous inference, which will help to advance research in these disciplines. Through our methods, researchers and policymakers will be equipped with information along with measures of uncertainty that are necessary for making sound decisions in a timely manner.
To address these current global needs, the Statistics Program at KAUST will be hiring multiple open-rank positions with expertise on these two modern core areas:
- Statistical Data Science with emphasis on high dimensional statistics.
- Statistical Data Science with computational methods.


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In honor of March Madness NCAA Basketball Championship Game Day (Men's and Women's) is a grade eight short speech written about the pressure of an athlete from a 13 yr. old girls perspective. As a parent of a child who has encountered obstacles and social interference about her basketball dreams and aspirations she stays strong and determined. The RISE (Realize Individual Success Everyday) Centre is a vision and concept many high-level sport professionals have embraced. McMaster University Athletes Edge will train our athletes at a level proven for success. The RISE will give extraordinary athletes learning opportunities through The Hill Basketball Academy to flourish and guide in their athletic endeavours. I am very proud of Aerial Wilson's perspective of life on and off the court. I hope you too enjoy how this young lady is dealing with the "PRESSURE" to pursue her basketball dreams.
by Aerial Wilson, March 01-2015
Small. Misshapen. Insignificant. A lump of coal! Ordinary, yet extraordinary, but what happens once it is under pressures of 725 000 pounds per square inch? What happens to a black piece of rock that does well under pressure? It becomes a diamond.
The most beautiful things are created from pressure, like us as individuals. Some can thrive under pressure and some of us will bow down and succumb to it. Those of us, who have the right mentality, come out of the fire as diamonds. They're the peak performers that not only have trained and worked hard, but won't crumble when the time approaches to make their dreams come true. They can perform in high-pressure situations without surrendering to their doubt demons. They're the one's titled "Most Valuable Player", the one's who hit the game-winning buzzer beater shots, they're the clutch players who can play and push through adversity. They're the ones who attack life as a challenge, not a threat.
We all choke, but what separates two people with the same skill set is how they perform due to pressure. What's your skill worth if you can never use it when it matters? You can have all the talent in the world but if you can't use it in a game, it's worthless. Pressure is always viewed as a negative, but that is just a mental roadblock keeping you from peaking. You can perform either 15% worse or 15% better under pressure. Those who are successful feed off the pressure to maximize their full potential, but in order to perform with more proficiency you must have a positive mindset. It is a proven fact that those who face high-pressure situations with a challenge state have blood flow more efficiently to their brain allowing them to have control over their thoughts and emotions. Where when we approach the same situations with a threat state our blood vessels constrict, causing us to cease up, hindering our ability to think and therefore perform at our best.
Nausea, sweaty palms, dry-mouth, about to throw up any second. I'm sure we've all felt it. Sure it's because I'm nervous, but what's there to be nervous about it's just another game, I've played amazing on countless occasions before, I'm a good player. If I go out there and play a terrible game or lose it'll be okay. Worst-case scenario: I'll go home and sleep. No. I'm older now, and getting exposure, I have to play well in practice to get playing time and prove that I'm the best on the court. I can't have a slump, because you never know who's watching. It could be scouts, the team Ontario or Canada coach, or anyone who wanted to watch our game because they're recorded. I want to do well so badly, I want to get noticed, want to play my best; I have to play my best. Every game is big and championships even bigger. Everyone watching. I have one opportunity to make it happen. One shot.
All of the pressure I'm feeling right now is a good thing. It's making me work harder to get where I want to be. I am the only one putting pressure on myself because I have expectations. If I feel that something isn't the best I can make it, then I'll do even more to make sure that it is and I'm rarely satisfied. The added pressure can be overwhelming, but I will always resist the temptation to give up because the pressure I've put on myself is my motivation.
What do we think when a coach yells, "Put pressure on the ball." Get up, get low and play defense. Don't. Let. Them. Breathe. Chances are if you do that the other team will have a pretty hard time scoring, yet they may have one player that can play with the added pressure. If it were easy everyone would do it. That's the difference: under pressure your true character is revealed. It defines you as a person. It will either make or break you. The ones who won't panic, won't fear, and won't settle are the successful people in life. Although we see pressure as a bad thing it is actually good. It is an opportunity to rise. Not just to be seen as someone who can play, but as someone who can think. It forces us to attack life with a challenge mindset that only allows positive thoughts. No more, "Don't miss," only, "It's going in." And even if that shot somehow misses, keep your head up, hustle, and know it's O.K to fail, but you better make sure that next time you have an opportunity that you take it. No pressure.


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New Humanities & the Anthropocene
How can the humanities accomodate the transformations associated with advances in science, technology, medicine, with the Anthropocene, climate change, and the "great acceleration" of planetary damage? How can we, with and within the diverse registers of arts and humanities, learn to live on a damaged planet? With short interventions from journalists, scholars, educators and artists, we gather for an Open Humanities Lab to listen to a plethora of suggestions and inspirational ideas from geo-humanities, environmental humanities, gender studies, eco art and bio philosophy, etc. Welcome! After all, arts and humanities is for everybody!
Time: Tue 2019-05-14 10.00 - Wed 2019-05-15 12.00
Location: Open Lab Valhallavägen 79
Webaddress for more information:


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The Winter of 1877-78 is the warmest Meteorological Winter on record in the Twin Cities.
The winter of 1877-78 was dubbed the "Year without a Winter." Indeed, the winter of 1877-78 is the warmest winter on record for the Twin Cities with a December-February average temperature of 29 degrees. The next winter that compares is 1930-31 with an average temperature of 26.9 degrees. In 3rd place is the winter of 2001-02 with 26.8 degrees.
So, how did the residents of the Twin Cities feel about their record setting warm winter in 1877-78? While residents may enjoy the ease of driving around the Twin Cities in 2012, travel was a hardship in the winter of 1877-78 for a population who depended on travel by horse and sleigh. Most roads were dirt, and the lack of snow hampered travel. Businesses were affected by the inability to move goods.
Farmers near Minneapolis were plowing fields until late December 1877. But in spite of the general warmth, three days with subzero temperatures in early January 1878 froze the Mississippi River in Saint Paul so that it was closed for navigation until the 28th of February. After January 7 only three days through the remainder of the 'cool' season would experience single digit temperatures or lower.
The "Monthly Weather Review" from February 1878 reported prairie fires in Minnesota, Dakota, and Kansas. In that same month active insects in Iowa, grasses sprouting in Dakota, and the ice cover in Duluth harbor broken up by heavy winds were all reported.
The continuing warmth of March 1878 allowed the first boat arrival in Duluth on the 17th. From research done by naturalist Jim Gilbert, Lake Minnetonka ice is known to have gone out at the earliest date on record, March 11, some 33 days earlier than its average ice-out date of April 13. Lake Osakis lost its ice on March 13th, the earliest in 142 years of records.
The winter of 1877-78 while warmest of record at Minneapolis-St. Paul, was not a dry winter. The months of December 1877 through February 1878 saw 3.09 inches of precipitation. For comparison, the 1981-2010 normal for December through February is 2.83 inches.
Below are interesting excerpts from the Minneapolis Tribune, courtesy long time climatology volunteer Tom St. Martin.
Minneapolis observer William Cheney regularly prepared monthly newspaper weather summaries which, to the extent that they were published, augment and sometimes clarify data contained in his meteorological registers as submitted to the U.S. Weather Bureau/ U.S. Army Signal Corps. The following comments are taken from the observer?s reports as published in various 1877-1878 editions of the Minneapolis Tribune:
November 1877: Warmest November since 1870. Rain on the 1st and 2nd with snow on the 7th and 8th falling to a depth of three inches. Two inches of snow on the 18th. Three inches of snow on the 27th and 28th accompanied by a high wind. Snow on the 8th and 18th melted soon after it fell. Rain on the 21st made the roads bad. Large proportion of cloudy weather.
December 1877: Unprecedented, untimely, unpleasant and sub-boreal weather. Large number of foggy and rainy days. Deep mud. Farmers plowing as late as the 23rd. River free of ice above and below Lake Pepin up to the last day of the month. Flowers blooming on the 28th. Five inches of snow on the 4th and 5th gave a short period of good sleighing. Rain fell more or less every day from the 17th to the 27th, inclusive. Heavy fog on 18, 19, 20, 21. Sleighing entirely gone by mid month with roads almost impassible because of mud. Only four entirely clear days and fifteen cloudy days. Closest approach to December 1877 was December 1857.
January 1878: The month was colder than December but unusually warm for January...there were only two very cold days during the month...no snow fell in sufficient amounts for sleighing until the 30th when about six and one half inches of light snow gave pretty good sleighing in the city but not sufficient for heavy teaming. The mud of December frozen by the cold of the first few days of January made the roads exceedingly rough and travel thereon very uncomfortable. The absence of snow proved a serious drawback to business of all kinds...thirteen cloudy days...
February 1878: This month closes the most remarkable winter ever known in Minnesota. Scarcely any sleighing, muddy roads, some fog, only five days...below zero,...and a mean temperature ten degrees warmer than any winter of which I have any record...The almost entire absence of snow has been somewhat detrimental to business generally and has proved a serious drawback to logging...The winter certainly has been a pleasant and comfortable one, making small demands on the fuel pile...While the mean temperature of the month was about the same as February of last year, it was in some respects less pleasant. There was more cloudy weather and two storms gave us five and one fourth inches of snow, making considerable mud...The season is not quite so far advanced as last year though wheat sowing is reported to have begun in some parts of the state...thirteen cloudy days....
March 1878: This was decidedly the warmest March of which I have any record...being 21 degrees warmer than the average of March for the last thirteen years and twelve degrees warmer than the average of 33 years at Ft. Snelling. There were occasional showers throughout the month, which, together with the mild temperatures, served to bring forward vegetation very rapidly...Wheat sowing was nearly all completed before the close of the month....No snow fell except for a slight sprinkling on the morning of the 30th, no enough to whiten the ground...six cloudy days....
April 1878: This month, like its immediate predecessors, was an exceptional one, being the warmest April of which I have any record....Only once during the month...did the thermometer fall below freezing...The rainfall was fully up to average...so that vegetation made steady and rapid progress...nine cloudy days...
May 1878: While the winter months and the first two months of spring were exceptionally warm, the month of May was unusually cold, being the coldest May since 1867....no serious frosts have occurred, however, and with the abundance of rain, the weather has, on the whole, been very favorable to crops...The rain was...well distributed throughout the month, although the larger part fell in the latter half....a slight sprinkling of snow on one day...."


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Give a great BIGkick™ to your creativity! The BIGkick works with the entire Sizzix® product library (with the exception of Bigz™ Plus and Bigz Pro dies) - and that includes our smallest dies to our big 6" wide plastic-backed treasures and embossing tools.
If that wasn't big enough, this portable roller machine cuts and embosses many different materials. Create your own one-of-a-kind cards, invitations, scrapbook pages, home décor, fashion, altered art, quilting and much more! (To ensure compatibility, always check accessory requirements. Machine accessories may be sold separately.)
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Slo-Niacin Polygel Controlled-Release Niacin, 250 mg, Tablets - 100ea
Slo-Niacin Polygel Controlled-Release Niacin, 250 mg, Tablets - 100ea
- Size: 100 Tablets
- Manufacturer: UPSHER-SMITH
Slo-Niacin Tablets are manufactured utilizing a unique, patented polygel controlled-release delivery system. This exclusive technology assures the gradual and measured release of niacin (nicotinic acid) and is designed to reduce the incidence of flushing and itching commonly associated with niacin use. Slo-Niacin Tablets are available in 250 mg, 500 mg, and 750 mg strengths.
PURPOSE: Dietary Supplement
Adults: One Slo-Niacin Tablet morning or evening, or as directed by a physician. Before using more than 500 mg daily, consult a physician. Note: Slo-Niacin Tablets may be broken on the score line, but should not be crushed or chewed. Store at controlled room temperature, 15-30 degrees C (59-86 degrees F). Keep tightly closed.
1 Tablet: Niacin USP (Nicotinic Acid) 250 mg; Hypromellose; Hydrogenated Vegetable Oil; Silicon Dioxide; Magnesium Stearate; Glyceryl Behenate; Red 40
Niacin may cause temporary flushing, itching and tingling, feelings of warmth and headache, particularly when beginning, increasing amount or changing brand of niacin. These effects seldom require discontinuing niacin use. Skin rash, upset stomach, and low blood pressure when standing are less common symptoms; if they persist, contact a physician. Slo-Niacin Tablets should not be used by persons with a known sensitivity or allergy to niacin. Persons with heart disease, particularly those who have recurrent chest pain (angina) or who recently suffered a heart attack, should take niacin only under the supervision of a physician. Persons taking high blood pressure or cholesterol-lowering drugs should contact a physician before taking niacin because of possible interactions. Case reports of myopathy (unexplained muscle related complaints, including discomfort, weakness, or tenderness) have been documented with the use of HMG-CoA Reductase Inhibitors in combination with lipid-altering doses of niacin therapy (> or = 1 gram of niacin per day). Do not take niacin unless recommended by and taken under the supervision of a physician if you have any of the following conditions: gallbladder disease, gout, arterial bleeding, glaucoma, diabetes, impaired liver function, peptic ulcer, pregnancy or lactating women. Increased uric acid and glucose levels and abnormal liver function tests have been reported in persons taking daily doses of 500 mg or more of niacin. Discontinue use and consult a physician immediately if any of the following symptoms occur: persistent flu-like symptoms (nausea, vomiting, a general 'not well' feeling); loss of appetite; a decrease in urine output associated with dark-colored urine; muscle discomfort such as tender, swollen muscles or muscle weakness; irregular heartbeat; or cloudy or blurry vision. Keep out of reach of children.


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The Flipover Vanish Box is a long time favorite here at MagicTricks.com. This newest version is designed to hold EVEN MORE of a load. Try it with a spring animal puppet like Tricky Fox or a huge bunch of silks!
An incredibly easy and deceptive way to vanish a live animal (or anything that will fit into the box), with no assistant needed!
The FlipOver Vanish Box shows up well at a distance, and has a wonderful "now you see it, now you don't" feature. Simply place a small rabbit, dove, guinea pig or ferret into the box. Let the box gently flip over, letting the sides swing open wide- the animal has vanished!
Safe for the animal, this quality prop is made specifically with the comfort and safety of your animal in mind. Best of all, the Flipover Vanish Box keeps the animal confined and secure after the vanish, allowing you to continue with your routine without worry about the animal.
Comes with beautifully made brightly painted wooden box and printed instructions. Box is 13"x8.5"x5". Live animal not included.
You supply the item to vanish.Box is 13"x8.5"x5".


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Exam (elaborations)
ATI RN Medical-Surgical Proctored Focus Exam Elaborations
- Course
- ATI RN Medical-Surgical
- Institution
- ATI RN Medical-Surgical
ATI RN Medical-Surgical Proctored Focus Exam Elaborations[Show more]
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This icon is a wall painting or fresco from a church near Athens, Greece. The bright blue colors so prominent here are unusual in iconography and this is one of several frescos from this same church. Here, Christ is telling Andrew and Peter in their boat, who had been cleaning their nets when Jesus approached them, to let down their nets, even though they had not taken any fish the previous night. St. John and James can be seen on the shore still cleaning their nets with their father Zebedee.
The creative Word of God, "…by Whom all things were made…" as we say in the Nicean Creed, is Jesus Christ come in the flesh. If He speaks, Creation responds most positively. When the net is lowered, such a shoal of fish is immediately caught that they call their partners John and James, and even together their boats almost sink under the weight. It was the most impressive moment of fishing in their lives, yet immediately on coming to land they left all that they had, as Jesus called them to discipleship and to become fishers of men. We, too, are called, not to apostleship, but to discipleship, so O Lord bless that we respond right away with love.


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Download video Falz Le Vrai Bahd Guy mp4
Download video Falz Le Vrai Bahd Guy mp4. Falz drops yet another brand new video titled "Le Vrai Bahd Guy". This is one of the top singles on Falz's third Album titled "27".
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text:
Fritz Pregl
Nobel Lecture
Nobel Lecture, December 11, 1923
Quantitative Micro-Analysis of Organic Substances
In accepting the honour of addressing this illustrious assembly on this proud occasion today, I am complying with § 9 of the Statutes of the Nobel Foundation, and I would like to take the opportunity at the same time of expressing my humble thanks to the Swedish Academy of Sciences for awarding me the Nobel Prize for Chemistry for the year 1923.
Already two years ago I had the honour of delivering two lectures to experts in the Kemiska Sällskapet (Chemical Society) on the subject of the quantitative organic micro-analysis developed by me. The nature of my task today does not permit me to present all the details described and demonstrated at that time, neither does the time allocated allow me to execute two important experiments; I can therefore only give a survey of the origin, the development and the final results up to date of quantitative organic microanalysis.
I had felt an inner compulsion to carry out the analysis of organic substances with much smaller quantities than had hitherto been used at a time when I was working on an investigation of a substance which could be obtained in extraordinarily small quantities; I was therefore forced to decide whether to process tons of material or whether to search for new methods, which would enable me to arrive at correct analytical results while using much smaller quantities then previously. I decided on the latter course of action. The most obvious plan was to apply reductions to all and everything, namely to move the decimal point back one or two places, not only in relation to the quantity of the substance, but also in relation to all the apparatus, reagent quantities, etc., involved.
This resulted not only in the necessity of carrying out all weighings with far greater accuracy than the customary analytical balances permitted, but the balance also had to be constructed in such a manner that the diversely shaped devices that were to be weighed could be accommodated on them. The assay balance for precious metals by Wilhelm Kuhlmann in Hamburg, which at that time was already being used in other laboratories for weighing with accuracy of 0.01-0.02 mg, fulfilled these requirements to a high degree. The designer, most fortunately, carried out great improvements to it at my suggestion, so that it is now possible to weigh with an accuracy of ±0.001 mg over a range of 20 grams using the micro-chemical balance designed by him and now in common use.
The assumption that our aim could be achieved by shifting the decimal point for all factors proved to be entirely misleading; for, following the reduction of the quantity of the substance, effects appeared which decisively influenced the result of the micro-analysis, whereas they had been insignificant in macro-analysis and had therefore often not even been noticed.
This can already be very simply illustrated in relation to nitrogen determination according to Dumas. The volumetric determination of the nitrogen set free during this process is influenced to such an extent by the 50% potassium hydroxide solution adhering to the interior of the measuring tube of the micro-nitrometer, that 2% must be deducted from the volume reading. Requirements regarding the carbon dioxide used for deaeration and for expelling the nitrogen are very much more exacting than one had hitherto been accustomed, and it was found necessary to develop a carbon dioxide supply which was completely free from air. Up to now there has been no lack of work in this direction and it is peculiar that nearly always the massive, compact marble was suspect as carrier of air; it was even found necessary to boil it off in a vacuum, and the fact was overlooked that aqueous solutions like hydrochloric acid are capable of absorbing considerable quantities of air, and also of nitrogen. Further, it was found to be imperative that the alkali sealing off the volume of nitrogen that had been set free, should not foam; treatment with barium hydroxide was found to be the means by which the substances that caused the foaming could be extracted from the alkaline solution. Finally, the position of the reduced copper mass in the tube lining was found to be of importance and the most correct position proved to be in the middle of the copper oxide lining in the hottest part of the tube.
The development of the determination of carbon and hydrogen was considerably more difficult, because the problem here was firstly to absorb the resulting combustion products free from foreign admixtures and, secondly, in such a manner that the increase in weight could only be related to the resulting water and the carbon dioxide which had been produced. Thus, for instance, even the use of clean air and pure oxygen can result in incorrect weight increase, if the gases are conducted through new rubber tubes, because these release noticeable amounts of vapours containing carbon and hydrogen into the stream of gas. Artificial ageing, for instance by passing steam through these tubes for one hour, can eliminate this undesirable property.
If the substance which is to be analysed contains nitrogen, halogen, or sulphur, gaseous products may result during combustion, which might erroneously be weighed and recorded as carbon dioxide, because they are also retained by the absorbing agent for carbon dioxide, i.e. soda lime. In such cases, therefore, entry of such products into the absorption apparatus must be prevented at all costs. Whereas for macro-analysis different tube linings are recommended for the various substances in accordance with their composition, my main aim was to develop a tube lining which would always retain everything that was not carbon dioxide or water. I therefore call it the universal lining. It consists of a mixture of copper oxide and lead chromate between two layers of silver and finally a layer of lead peroxide on asbestos heated to 180°C.
Since the invention of Liebig's potassium apparatus and the calcium chloride tube, many variations have been made in the course of nearly a century to the usual absorption apparatus for elemental analysis. I chose for this purpose the simplest form, a tube. It is quite obvious that the slightest impurities must cause special errors. Warming caused by wiping, wrongly makes these small devices appear to be lighter in weight; then, when they have not been filled, they attain a constant weight within 10-15 minutes. However, if they contain an absorbing agent and if their connections are open at both ends and are not tapered, they will increase in weight at the same rate after that period has elapsed, that is to say, they absorb from the air water vapour and therefore become heavier. I have finally succeeded in completely preventing this diffusing-in of water vapour by fitting capillary tapering pieces between larger and smaller expansions of the flow line; this arrangement represents such a gradual diffusion gradient that even for the sensitive weighing instrument of the micro-analyst unnoticeable weight increases during the periods under practical consideration will result.
On the other hand, these capillary taperings present considerable resistance to the gas stream resulting in an increase of pressure in the interior of the combustion tube. New difficulties arose hereby; the tube connections between the apparatuses, particularly between the warm outlet of the combustion tube and the calcium chloride tube – the most critical spot – could cause the loss of combustion products in consequence of the increased pressure, if the tube connection is only slightly damaged, and especially in view of the fact that rubber has the peculiarity of allowing carbon dioxide to diffuse easily. I eliminated these hazards by equalizing the pressure at the critical place to that outside, i.e. the atmospheric pressure. This effect can easily be achieved by means of a Mariotte's flask.
Right from the start I had rejected the idea of forming the connections between the apparatuses and the combustion tube by ground glass joints and of using cocks for closing the absorption apparatus, because these cannot safely and easily be wiped and would also be in danger of being broken on account of their fragility. On the contrary, I am convinced that microanalysis, its development and wider use will be best served by avoiding cocks and ground joints.
When all these conditions are observed, it is quite easy to obtain accurate analysis results for 2-4 mg of the substance. The smallest quantity ever used was 1 mg and the divergence was still within the usual permissible margin of error. In doing this we have quite exceptionally reduced the amount of substance required for the analysis. Bearing in mind that Liebig used 0.5 g of substance and originally even 1 g, and that towards the end of the last century 0.15-0.2 g was usually considered to be the quantity required, we may well say that the development of micro-analysis has reduced the quantities required for the determination to about one hundredth part of what ten years ago was considered to be the amount required. This reduction does not impair the accuracy in any way and I can even say that my students demand far greater accuracy from micro-analysis than they previously expected from macro-analysis. This probably follows from the fact that the basic conditions are far better and can be more completely allowed for than was possible with macro-analysis. There are two further advantages that should be borne in mind. Firstly, there are great savings in gas and reagents, and secondly, and this is even more valuable, there is a saving in time. Thus it is possible to attain the same result in at least one third of the time required for macro-analysis; a decision then to repeat micro-analyses is much easier made, as the work is much shorter and more pleasant.
For the determination of halogens and sulphur Carius' method was originally generally used. The precipitates obtained then used to be sucked out in a small Gooch crucible, I particularly would like to mention here briefly that I was the first to recognize that the presence of barium chloride was essential for the decomposition of sulphur-containing substances with nitric acid; without this, losses were certain to result. Later a completely new analytical process for the decomposition of organic substances was discovered, which consisted in burning them in an oxygen stream and then leading the combustion products over red-hot platinum in order to complete the decomposition. With halogen determinations, these combustion products are collected in an alkaline sulphite solution, whereas the products from sulphur determinations are collected in perhydrol, with which porcelain beads are wetted. All this is done in one single hard-glass tube and this may be used many hundreds of times for the same purpose. All the halogen is obtained with the washing liquid in the form of sodium halide, all the sulphur in the form of sulphuric acid. Here also there were initial difficulties with the determination of the halogen, because the values obtained after acidifying the alkaline sulphite solution with nitric acid were too high. The explanation was that the oxidation of sulphite to sulphuric acid does not proceed directly, but by the precipitation of elementary sulphur, which would indicate that this reaction does not proceed monomolecularly, but probably by way of a polythionic acid. For, if we first use perhydrol as oxidizing agent in alkaline solution and then acidify with nitric acid, sulphur is not precipitated and fully correct results are obtained. The resulting silver halides are automatically sucked on to a filter tube and weighed after drying. Similar analytical instructions resulted with sulphur determinations; if these instructions are observed, correctness of the analytical results can be guaranteed.
My assistant, lecturer Dr. Hans Lieb has developed methods for the determination of phosphorus and arsenic in organic substances, by which satisfactory results are achieved.
Apart from the quantitative determination of the elements making up the structure of organic substances, the quantitative content of certain groups of atoms is also of the utmost importance. I have therefore developed the determination of the carboxyl group by acidimetry by using phenolphthalein as indicator; I have further elaborated the determination of the methoxy and methylimide groups. I do not want to go into details, but would nevertheless stress the enormous simplification of the micro-apparatus as compared with the macro-procedure in connection with the methoxy determination; the weighing of the substance in tin-foil caps is new in principle and of great advantage, as the hydriodic acid does not bump because of its tin iodide content. For the methylimide determination, the fact that the ratio of the hydriodic acid to the substance quantity used (approx. 3 mg) would be far more favourable than for the macro-analytical process, had not been foreseen. This was for the first time noticeable in connection with physostigmine, as only by micro-analytical methods a third methyl or ethyl group was detected, where previously only two had always been assumed, so that the structure of this body had to be revised for this reason.
Determination of the molecular weight by the boiling-point method has also become practicable through micro-analysis, as we are able to obtain reliable values for a quantity of 7 mg.
It is hard to believe that the simplest of all determinations, i.e. the determination of the residue through fuming with sulphuric acid, as is necessary with the determination of Na, K, Ca, etc. in organic substances, could only be adapted in such a way as not to make too great demands on the skill of the analyst and yet give satisfactory results that beginners always think they are mere accidents, long after the previously described difficult methods had been developed.
Finally it might not be superfluous to raise the question what positive results micro-analysis has achieved so far.
In this connection we may mention that one of the first results was the discovery that the yellow colouring matter in corpora lutea of cattle ovaries was by micro-analytical carbon hydrogen determination found to be carotin, the substance which is in carrots widely found in the vegetable kingdom. This was extracted from approximately 10,000 ovaries in the Willstätter Laboratory in Zurich and would have been sufficient for only one macro-analysis. Thus, in this case already micro-analysis has made possible important progress in our knowledge, by proving that the same substance appears as colouring matter in both natural kingdoms, the vegetable as well as the animal kingdom.
Also, in view of the minute quantity of material available, I want to draw your attention to the valuable information on molecular structure obtained by means of micro-analysis, through the work of Adolf Windaus on cymarin and cholesterol, and Wieland's work on the decomposition of bile acids, where micro-analysis proved its value.
Last but not least I want to mention that quite recently a Swede, C.A. Yllner applied micro-analytical methods successfully at my Institute in Graz for the identification of alkaloids in forensic cases, that is, when these had to be extracted from dissected corpses. During the last few years my methods have also been applied in technology for electrolytic metal analysis; and for the analysis of wine very clever micro-analytical methods have been developed, apart from those discussed here.
I therefore am very hopeful that in the future quantitative organic microanalysis will find many more fields of application and expansion, and that it will make possible much insight and discernment which otherwise might not have been possible, especially following the magnificent recognition that has been awarded to it by the Swedish Academy of Sciences.
Coming up
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text:
Tuesday, 08 July 2014 09:44 PM EDT
Israel on Tuesday launched its largest offensive in the Gaza Strip in nearly two years, carrying out a blistering aerial assault on scores of targets and killing 25 people in what officials called an open-ended operation aimed at ending weeks of heavy rocket fire.
As Gaza militants unleashed salvos on cities including Jerusalem and Tel Aviv, Israel mobilized forces along the border for a possible ground invasion.
The offensive set off the heaviest fighting between Israel and the Islamic militant group Hamas since an eight-day battle in November 2012. The militants fired about 160 rockets at Israel, including a strike that reached the northern city of Hadera for the first time, while Israel said it attacked more than 150 sites across Gaza.
Palestinian medics reported at least 25 dead, including six killed in an airstrike that flattened an apartment building in southern Gaza and set off widespread panic.
Prime Minister Benjamin Netanyahu said continued rocket attacks on Israeli communities would not be tolerated.
"Therefore I have ordered the military to significantly broaden its operation against Hamas terrorists and against the other terrorist groups inside Gaza," he said on national TV. "I call on you to display patience because this operation could take time."
Israel and Hamas are bitter enemies that have engaged in numerous rounds of fighting over the years. But until recently, they had been observing a truce that ended the previous hostilities in 2012.
Tensions have been rising since Palestinian militants kidnapped three Israeli teenagers in the West Bank on June 12. Accusing Hamas of being behind the abductions, Israel launched a crackdown on the group's members in the West Bank and arrested hundreds of people. Hamas, which controls Gaza, responded by stepping up rocket fire.
The situation deteriorated last week after the bodies of the Israeli youths were found, and a Palestinian teenager in Jerusalem was abducted and burned to death in what Palestinians believe was a revenge attack. Six Jewish Israelis have been arrested in the killing, and the rocket fire from Gaza has increased in recent days.
The fighting raged throughout the day. In its fiercest attack, an airstrike flattened the home of a Hamas militant in the southern Gaza town of Khan Younis, reducing the concrete structure into a smoldering pile of rubble.
Panicked residents fled, shouting "God is great." Some had bloody faces, and crying mothers held small children as they ran away. Screaming Palestinians took away motionless bodies. Palestinian medical officials said six people, including two children, were killed. Israel's military said it had called the home shortly before the airstrike to warn civilians to leave, something it has done in past fighting as well.
The normally bustling streets of Gaza City were deserted late Tuesday. Fearing an Israeli ground operation, many residents from areas near the border moved to stay with relatives living deeper inside Gaza.
In southern Israel, hundreds of thousands of citizens were ordered to stay close to home because of the rockets. Israeli streets were also quieter in Tel Aviv and Jerusalem after attempted rocket strikes set off air-raid sirens in Israel's two largest cities. The Jerusalem municipality said it was opening special bomb shelters.
Militants twice fired rockets at Tel Aviv, Israel's commercial capital, sending people scurrying for cover. Both were intercepted by the "Iron Dome" rocket defense system, with the second shown on live TV, as a winding plume of smoke followed the interceptor into the black skies, culminating with a flash.
Late Tuesday, Hamas said it fired four rockets toward Jerusalem, and two distant booms were heard from the city's center. Three rockets landed in the Jerusalem area, officials said, and police said there were no injuries.
The Israeli military said one rocket exploded in the northern Israeli city of Hadera, about 60 miles from Gaza, in the farthest distance a rocket from Gaza has reached so far. It caused no injuries, the army added. With its new reach, Hamas' rockets now have an estimated 5 million people — more than half of Israel's population — in range.
Hamas said it had used a new rocket called the R-160 after one of its leaders, Abdel Rantisi, who was killed last decade.
In other violence, the Israeli military said it foiled Gaza militants who tried to infiltrate a military base in southern Israel by sea. Lt. Col. Peter Lerner, a military spokesman, said four attackers came ashore and attacked the base with grenades and automatic rifles before they were killed. An Israeli soldier was slightly wounded.
As Israel built up forces along the border, the government authorized the army to activate up to 40,000 reservists. The army said that about 1,000 soldiers were immediately activated, in addition to an earlier group of 1,500 reservists called into action.
"If we need to go inside in a ground operation, then we will do it. These things are on the table. These options exist. We will not stop anything until the rocket firing ends," said Yitzhak Aharonovitch, the minister for internal security and a member of Netanyahu's inner Security Cabinet. Israel's last ground offensive was in 2009.
Asked by Channel 2 TV if there were any efforts underway to reach a cease-fire, he said: "Not now."
The U.S. State Department condemned the rocket fire on Israeli civilians, defended Israel's right to protect itself, and said it hoped Israel's "strong message" would deter further attacks. "But certainly, our preference is to de-escalate the situation on the ground," spokeswoman Jen Psaki said.
Israel and Hamas, which is sworn to the destruction of the Jewish state, agreed to an Egyptian-brokered cease-fire that ended the last round of fighting in late 2012.
In Gaza, Abu Obeida, a masked spokesman for Hamas' military wing, accused Israel of violating that agreement and demanded a halt to the airstrikes, its recent crackdown in the West Bank and its opposition to a Palestinian unity government that is backed by Hamas.
"In the face of this aggression, we affirm that the Zionist enemy should not dream of calm and stability," he said.
Hamas, however, is far weaker than in 2012. At the time, Egypt was governed by the Muslim Brotherhood, Hamas' close ally. Following a military coup in 2013, Egypt's new government is hostile to Hamas and has closed a network of smuggling tunnels used by the group as an economic lifeline.
Hamas seized control of Gaza in 2007 from the rival forces of President Mahmoud Abbas. But facing international isolation and an economic crisis, Hamas last month agreed to back a new unity government with Abbas.
Abbas, however, has little real influence over Gaza. Hamas, with an arsenal of thousands of rockets, remains the dominant power there. Smaller and more radical forces are also involved in rocket fire from Gaza.
U.N. Secretary-General Ban Ki-moon condemned the multiple rocket attacks on Israel from Gaza and demanded an immediate halt to the attacks, U.N. spokesman Stephane Dujarric said. Arab League Chief Nabil Elaraby called for an emergency session of the U.N. Security Council to stop the violence.
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text:
[John] is keeping the neighborhood safe by keeping an eye out for speeders. Well, he's really keeping a webcam out for speeders. His technique doesn't use radar or lasers. He's processing webcam frames in Python to calculate speed.
It comes down to some basic image manipulation. He firsts gathers the images necessary to make the calculations by using a motion-detecting webcam program called YawCam. The images are analyzed to establish which parts have changed between frames; this gets rid of all the stationary objects. Now the frames can be compared to establish the distance in pixels. By calibrating the shot through measurements of the target area, this data can be directly converted into actual distance. It is then compared with the timestamps from each frame to arrive at speed. This can be used for vehicles on the street like we see above, or more whimsical measurements like pet turtle progress.


text:
# $EPIC: on_public_notice.txt,v 1.2 2006/08/19 02:36:28 sthalik Exp $
on [<modes>]public_notice [<serial#>] [-|^]<match> { <action> }
This hook is triggered whenever a NOTICE is sent to any channel the client is on from someone not actually on that channel.
This hook will not be thrown if a matching ON GENERAL_NOTICE hook is being used in silent mode. ON GENERAL_NOTICE and ON PUBLIC_NOTICE are mutually exclusive.
|nickname sending message
|channel sent to
|text of message
To distinguish NOTICEs sent to the current channel vs. other channels:
on ^public_notice "*" { if ( [$1] == C ) { echo +$0+ $2- } { echo +$0:$1+ $2- } }
The client does not permit any automated messages to be sent in response to a NOTICE. Any attempt will result in an error. The whole point of this is to prevent loops between clients.


text:
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