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Lapatinib treats breast cancer. Can cause diarrhea and hair loss. Take it on an empty stomach. Women should not get pregnant while taking this medication.
Lapatinib Overview
Lapatinib is a prescription medication used to treat breast cancer. It is used in combination with other medications to treat a certain type of breast cancer that has spread to other parts of the body and that has not responded to other cancer treatments.
Lapatinib belongs to a group of drugs called kinase inhibitors which work by blocking the action of a certain protein that signals cancer cells to multiply.
This medication comes in tablet form and is taken once daily on an empty stomach.
Common side effects of lapatinib include red, painful hands and feet, diarrhea, rash, and nausea.
Lapatinib Genetic Information
Breast cancer is a cancer that forms in the cells of the breasts. Some women have (HER2+) breast cancer. (HER2+) stands for Human Epidermal growth factor receptor 2 positive. (HER2) is a special protein found on breast cancer cells that controls cancer growth and spread.
Lapatinib is approved for treatment of HER2 positive breast cancer, because it is specifically designed to target the HER2 protein. By binding to the HER2 protein, lapatinib prevents the growth of cancer cells.
HER2 testing is done to see whether treatment with lapatinib will likely be effective in treating breast cancer. If testing is not done, treatment with this medication may not be an effective treatment.
How was your experience with Lapatinib?
Pill Images
Lapatinib Cautionary Labels
Uses of Lapatinib
Lapatinib is a prescription medication used with another medicine (capcitabine) to treat people with breast cancer that has spread to other areas of the body that is HER2 positive (tumors that produce large amounts of a protein called human epidermal growth factor receptor-2), and who have already had certain other breast cancer treatments.
Lapatinib is also used with a type of medicine called letrozole for the treatment of postmenopausal women with hormone receptor positive, HER2 positive metastatic breast cancer for whom hormonal therapy is indicated.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Lapatinib Brand Names
Lapatinib may be found in some form under the following brand names:
Lapatinib Drug Class
Lapatinib is part of the drug class:
Side Effects of Lapatinib
Serious side effects have been reported. See "Lapatinib Precautions" section.
Common side effects of lapatinib in combination with capecitabine or letrozole include:
- diarrhea
- red, painful hands and feet
- nausea
- rash
- vomiting
- tiredness or weakness
- mouth sores
- loss of appetite
- indigestion
- unusual hair loss or thinning
- nose bleeds
- headache
- dry skin
- itching
- nail disorders such as nail bed changes, nail pain, infection and swelling of the cuticles.
Tell your doctor about any side effect that gets serious or that does not go away.
These are not all the side effects with lapatinib. Ask your doctor or pharmacist for more information.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
You may also get side effects from the other drugs taken with lapatinib. Talk to your doctor about possible side effects you may get during treatment.
Lapatinib Interactions
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal and dietary supplements. Lapatinib and many other medicines may interact with each other. Your doctor needs to know what medicines you take so he or she can choose the right dose of lapatinib for you.
Especially tell your doctor if you take:
- antibiotics and anti-fungals (drugs used to treat infections)
- HIV (AIDS) treatments
- anticonvulsant drugs (drugs used to treat seizures)
- calcium channel blockers (drugs used to treat certain heart disorders or high blood pressure)
- antidepressants
- drugs that decrease stomach acidity
- St. John's Wort or other herbal supplements
Know the medicines you take. Keep a list of your medicines with you to show your doctor. Do not take other medicines during treatment with lapatinib without first checking with your doctor.
Because lapatinib is given with other drugs called capecitabine or letrozole, you should also discuss with your doctor or pharmacist any medicines that should be avoided during treatment.
Lapatinib Precautions
Serious side effects have been reported:
- heart problems including, decreased pumping of blood from the heart and an abnormal heartbeat. Signs and symptoms of an abnormal heartbeat include:
- feeling like your heart is pounding or racing
- dizziness
- tiredness
- feeling lightheaded
- shortness of breath
- Your doctor should check your heart function before you start taking lapatinib and during treatment.
- liver problems. Signs and symptoms of liver problems include:
- itching
- yellow eyes or skin
- dark urine
- pain or discomfort in the right upper stomach area
- death
- Your doctor should do blood tests to check your liver before you start taking lapatinib and during treatment.
- diarrhea, which may cause you to become dehydrated. Follow your doctors instructions for what to do to help prevent diarrhea. Call your doctor immediately at the first sign of diarrhea, as it is important that this is treated right away.
- lung problems. Symptoms of a lung problem with lapatinib include a cough that will not go away or shortness of breath.
Call your doctor right away if you have any of the signs or symptoms of the serious side effects listed above.
Do not take lapatinib if you are allergic to any of its ingredients.
Lapatinib Food Interactions
Grapefruit and grapefruit juice may interact with lapatinib and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
Inform MD
Before you start taking lapatinib, tell your doctor about all of your medical conditions, including if you:
- ever had a severe allergic (hypersensitivity) reaction to lapatinib. Check with your doctor if you think this applies to you. Don't take lapatinib.
- have heart problems.
- have liver problems. You may need a lower dose of lapatinib.
- are pregnant or may become pregnant. Lapatinib may harm an unborn baby. If you become pregnant during treatment with lapatinib, tell your doctor as soon as possible.
- are breastfeeding. It is not known if lapatinib passes into your breast milk or if it can harm your baby. If you are a woman who has or will have a baby, talk with your doctor about the best way to feed your baby.
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal and dietary supplements.
Lapatinib and Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Lapatinib falls into category D. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans.
Lapatinib and Lactation
It is not known if lapatinib crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using lapatinib.
Lapatinib Usage
Take lapatinib exactly as your doctor tells you to take it. Your doctor may change your dose of lapatinib if needed.
- For patients with advanced or metastatic breast cancer, lapatinib and capecitabine are taken in 21 day cycles. The usual dose of lapatinib is 1,250 mg (5 tablets) taken by mouth all at once, one time a day on days 1 to 21. Your doctor will tell you the dose of capecitabine you should take and when you should take it.
- For patients with hormone receptor positive, HER2 positive breast cancer, lapatinib and letrozole are taken daily. The usual dose of lapatinib is 1,500 mg (6 tablets) taken by mouth all at once, one time a day. Your doctor will tell you the dose of letrozole you should take and when you should take it.
Lapatinib should be taken at least one hour before, or at least one hour after food.
Do not eat or drink grapefruit products while taking lapatinib.
If you forget to take your dose of lapatinib, do not take two doses at one time. Take your next dose at your scheduled time.
Lapatinib Dosage
Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
The dose your doctor recommends may be based on the following:
- the condition being treated
- other medical conditions you have
- other medications you are taking
- how you respond to this medication
- your weight
- your height
- your age
- your gender
The recommended dosage of lapatinib for advanced or metastatic breast cancer is 1,250 mg (5 tablets) given by mouth once daily on Days 1-21.
The recommended dose of lapatinib for hormone receptor-positive (HER2-positive) metastatic breast cancer is 1,500 mg (6 tablets) given orally once daily continuously in combination with letrozole.
Lapatinib Overdose
If you take too much lapatinib, call your doctor or poison control center, or go to the nearest hospital emergency room right away. Take lapatinib tablets with you when possible.
Other Requirements
- Store lapatinib tablets at room temperature at 59° to 86°F (15° to 30°C). Keep the container closed tightly.
- Do not keep medicine that is out of date or that you no longer need. Be sure that if you throw any medicine away, it is out of the reach of children.
- Keep lapatinib and all medicines out of the reach of children.
Lapatinib FDA Warning
Hepatotoxicity has been observed in clinical trials and postmarketing experience. The hepatotoxicity may be severe and deaths have been reported. Causality of the deaths is uncertain.


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A Quilt Made By You for You!
Looking great Julie!!!
I really like this block! There is so much going on in it! Very sweet!
Oh I love the soft pink of your brides block! Looks beautiful and it will be fun to watch your progress!
She looks gorgeous, Julie!

subset: commoncrawl


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August 18, 2022 by
The Problem When people use GIPHY, they are looking to express themselves in a fun and entertaining way. Certain search... more »
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As a software engineer, I've always been seeking ways to stay effective. Since I've been working in tech for... more »
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In this article, I will share the implementation details of an iOS SwiftUI app with CoreML features. The app captures a... more »
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To make it easier for React Native developers to implement GIPHY and let their users share GIFs, Clips, and more, we... more »
December 10, 2019 GIPHY HQ – New York, NY Join us and the MusicTech meetup for a night of demos... more »
October 10, 2019 GIPHY HQ – New York, NY Come join us on October 10th for another iteration of DevOps... more »
October 3rd, 2019 @ 26 Bridge, Brooklyn NY Come see us at The Round NYC on October 3rd where we'll... more »
September 25, 2019 GIPHY HQ – New York, NY Join us at GIPHY where 3D Print Fashion, in conjunction with... more »


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I didn't like cycling at all. I never rode a bicycle myself and I never watched road races. Even during the Tour de France I'd turn off the television. My boss asked me to give the Spinner® bike a try nonetheless. He persuaded me by offering free beers at the bar afterwards. After ten minutes on the bike I thought to myself: 'horrible, I never want to do this again.' The teacher was an older gentleman who was sitting in front of me and he was cycling much easier, more relaxed and with a very nice technique. That sparked my competitive nature. So I came back the next class and the next and the next. Once I went all out, I was hooked on the bike. This was in 1993. By now it's fair to say I'm a Spinning® lover. It's a way of life.
In the beginning I was a regular drill instructor who pushed people to their limits. If my riders didn't fall off their bikes completely exhausted, I thought I hadn't done a good enough job. I was teaching Spinning® classes anywhere between 10 and 20 hours a week. During that period I was getting more and more stressed out myself and I was on the verge of a burnout. I was travelling all through Europe searching for education and talking to different trainers. Johnny G taught me the philosophy behind the Spinning program, after which I started Spinning with love and feeling. Because of him I got a different perspective on life, on sports in general and Spinning in particular. Since I started applying his wisdom, I'm at the pinnacle of my own personal fitness again. This experience inspired me to become a Master Instructor. Now I'm able to reach out to other trainers and express my teaching philosophy to them, so they can share it with their own students.
I enjoy the Spinning classes because it's a workout for all fitness levels and age groups, so I can teach a class with vast variety. Every student has their own goals but is nevertheless a part of the group. It is simple yet powerful in the way that it can change both your physical and mental health. What I love most is the riders' drive to accomplish their own goals, the support for each other and the positive vibe in the classroom. And Spinning® is still a great challenge for me as well. It's all about the balance between body and mind.
Spinning is the perfect combination of physical exercise and mental relaxation. It gives you energy and you can get away from your everyday stress. Spinning is power, emotion and passion!
I don't have any specific favorite songs, but I do have a couple of favorite artists, so I'll name those.
There are always lots of memorable moments during the classes and it's very difficult to pick a favorite. The biggest satisfaction is seeing your riders crush their fitness goals. There are some big events I've participated in, of which I'm going to have to make a top three list because I have several memories I hold dear:
We empower respect!
Don't hesitate, just do it. Spinning is a fantastic workout and being part of a worldwide group of Master Instructors enriches your life. I would advise the newcomers to take regular classes from different trainers and find out what kind of program they enjoy teaching.
Knowing is not enough; we must apply. Willing is not enough; we must do.
My heroes are Giba Ambrogi from Brazil and Marc Reuland from Luxembourg.
I'm very good at making soup. Hearty soup. Soup with meatballs.


text: Home / Enzymes & Probiotics / Ultra Probioplex™ ND Probiotic Powder 50g (Approx. 66 Servings) by Nutri Advanced Ultra Probioplex™ ND Probiotic Powder 50g (Approx. 66 Servings) by Nutri Advanced£32.80 A healthy gut environment is essential for good health. Ultra Probioplex™ ND Powder is a non-dairy formula that contains a 50:50 blend of two extensively-researched strains of live bacteria: Lactobacillus acidophilus (NCFM™ strain) and Bifidobacterium lactis (Bi-07 strain). Ultra Probioplex™ ND Powder also features vitamin D, which contributes to the normal function of the immune system. Ultra Probioplex™ ND Probiotic Powder 50g (Approx. 66 Servings) by Nutri Advanced quantity Add to cart Category: Enzymes & Probiotics Description Reviews (0) Description Establishing balanced intestinal microflora between the 'friendly' and harmful bacteria begins at birth and continues throughout life. There are many factors in our modern lifestyle that can disrupt this delicate balance, such as stress, poor diet, antibiotics and many medications. This may result in digestive disturbances and an increased risk of infection. Ultra Probioplex™ provides an abundance of two strains of friendly bacteria which 'crowds out' the harmful bacteria and helps support a healthy balance of bacteria in the gut. The highlights of Ultra Probioplex ND powder include: Contains a guaranteed 15 billion live bacteria – an amount found to be clinically beneficial – all the way through to the expiry date The NCFM strain of Lactobacillus acidophilus is one of the most extensively tested and effective acidophilus species available Lactobacillus acidophilus is a human strain that has a proven history in supplements for over 25 years are one of the most abundant and perhaps the most important types of bacteria in humans. B. lactis Bi-07 is an extremely well-researched strain which has had demonstrable effects in humans. Both strains have been shown to survive stomach acidity and to adhere (stick) to the intestinal wall. These are both vital when choosing a live bacteria supplement. Guaranteed stability and potency. Suitable for adults, children and babies over 2 months Can be used during pregnancy and breastfeeding Key Ingredients: Each scoop (0.75g) typically provides % NRV* Lactobacillus acidophilus NCFM® 7.5 billion live organisms* ✝ Bifidobacterium lactis Bi-07 7.5 billion live organisms* ✝ Fructooligosaccharides (FOS) 405 mg ✝ Vitamin D3 (Cholecalciferol) (100iu) 2.5 µg 50 *at date of expiry * NRV is the Nutrient Reference Value ✝ NRV not yet established Other ingredients: Rice maltodextrin Recommended Usage: Mix one scoop (0.75g) with unchilled water one to two times daily Contra-indications: If pregnant, breastfeeding, taking any kind of medication or have a medical condition, consult a healthcare practitioner before using this product. Are there any side effects from taking probiotics? You may experience a change in bowel function/habits for a few days which may present as a gurgling/wind/change in bowel frequency. This is perfectly natural with taking any probiotic and will generally settle down after a week or so. Reducing the dosage may help alleviate this. Reviews There are no reviews yet. Be the first to review "Ultra Probioplex™ ND Probiotic Powder 50g (Approx. 66 Servings) by Nutri Advanced" Cancel replyYou must be logged in to post a review. Related products CandiSolve 120 Capsules by Nutri Advanced £49.95 Add to cart NUTRIGEST by Nutri Advanced £24.50 Add to cart Similase 180 Capsules by Nutri Advanced £48.45 Add to cart


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Learn about the staff that works in our school.
The school report card shows how a school is performing in multiple areas. It shows the school's strengths and the challenges that need to be addressed.
Read more about our initiative to improve our school.
The Massachusetts Department of Elementary and Secondary Education collects a variety of data from schools and districts in the state.
Our School Site Council is a committee made up of families, outside partners, NLIS staff, and the principal. The SSC meets quarterly and helps make decisions for the school.
We can accept up to 15 students from outside of Salem through the state's Inter-District School Choice Program.
The mission of the Student Support Team (SST) is to assist students, parents and teachers with services or types of interventions that foster a healthy and positive school community.
At New Liberty, partnering with families is of the utmost importance to us.
Staff at New Liberty believe in the mantra, "Reach before you teach." With each student we encounter, we seek to apply and deepen our awareness of the socio-political context of the classroom and the systemic and internalized biases that may be at play.
MCP empowers educators to build classrooms that respond to every student's need. They provide teaching training and support for implementing a self-paced, mastery-based instruction that leverages technology
The Special Education Department oversees the district's large network of special education providers and services that work to ensure that each child is provided a free and appropriate education.
English Language Learners (ELLs) at New Liberty receive support from our licensed ESL Teacher. Our teacher pushes in and pulls students out of class to provide them with the particular language support they need.
Project Liberty develops employment readiness in our students preparing them for career and life stability after high school.
« All Events
Accessibility Tools


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Anticimex is an international provider of pest control, built environment and food hygiene. They are the only company in Finland who provides digital solutions in pest control with its own SMART system.
Ecomond's TCS system is integrated to function with Anticimex systems and software platforms. Information from remote surveillance and pest control is transmitted via Ecomond TCS to Anticimex service technicians who have real-time task lists for the necessary measures.
" TCS is the cornerstone of all our combat work out on the field. We make about 50,000 anti-countermeasures each year, and TCS brings the necessary efficiency and quality to our operations, which is a vital priority for our customers, " says Jussi Ylinen, Managing Director of Anticimex.
Pest control management is an invisible activity for the customer, but in reality it is a highly regulated activity that involves a lot of guidance and reporting to the client and authorities. Previously, the pest control chain worked on paper forms and reports which included a lot of time consuming writing and filling in forms. Also the technicians' actions were recorded by hand, so, to know what to do next, the notes on previous steps needed to be carried along (a lot of paper and documents). The TCS system removes the paper reporting and eases on the workload.
The TCS system integrates seamlessly into Anticimex's own system and provides necessary task information to the service technicians. The system displays the most efficient task order and schedules the actions according to the given conditions. The technician does not have to rely on his own memory, as the system shows the whole history; what has been done, what traps and gears are used in the particular task and what will be the following steps. Since everything is electronic, the employee always has all the information he needs and the potential human error is significantly reduced.
The TCS system makes the workflow smooth and keeps the company and its employees up to date about the upcoming and implemented actions. The customer of Anticimex receives right away information about what has been done. Real-time task management system makes sure that the information of tasks carried out, reporting and billing is done without delay and without error.


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The Arts and Humanities Research Council has released details of the winners of its 'Digital Equipment and Database Enhancement for Impact' scheme.
21 projects have been funded at a value of just over £4m.
Dr GP Earl £232,575.00
School of Humanities, University of Southampton
Reflectance Transformation Imaging Systems for Ancient Documentary Artefacts
Professor J Ellis £332,520.00
Department of Media Arts, Royal Holloway, University of London
Consolidated Moving Image and Sound Database Framework
Dr BA Fennell £334,574.00
School of Language and Literature, University of Aberdeen
Language and Linguistic Evidence in the 1641 Depositions
Professor RS Fensham £347,592.00
Dance Film and Theatre, University of Surrey
Digital Dance Archives (DDA): cross-collection interactivity and enhanced user engagement with dance resources
Professor PH Gray £111,768.00
School of History and Anthropology, The Queen's University of Belfast
Documenting Ireland: Parliament, People and Migration, 18th-20th Centuries (DIPPAM)
Mr C Harrison £182,135.00
Ashmolean Museum, University of Oxford
The Elements of Drawing: Enhancement and Dissemination for Impact
Professor AF Hartley £159,293.00
School of Modern Languages and Cultures, University of Leeds
IntelliText – Intelligent Tools for Creating and Analysing Electronic Text Corpora for Humanities Research
Dr E Leach £191,189.00
Music Faculty, University of Oxford
DIAMM: Digital Image Archive of Medieval Music
Dr AA Marsden £139,505.00
Lancaster Institute for the Contemporary Arts, Lancaster University
Digital Arts Innovation Laboratory (DAILab)
Dr A Mazel £120,679.00
School of Arts and Cultures, Newcastle University
Rock Art Mobile Project
Dr M Melaugh £260,179.00
INCORE, University of Ulster
Visualising the Conflict: Immersion in the Landscape of Victims and Commemoration in Northern Ireland
Dr DT Murphy £109,606.00
Electronics, University of York
The Virtual Acoustics and Auralization Database
Dr D Obbink £113,487.00
Classics Faculty, University of Oxford
A Collaboration between Classics and Astrophysics: An Advanced Multispectral Imaging Laboratory Optimised through Crowd-Sourced Statistical Analysis
Professor W. R. Owens £100,778.00
Department of Literature, The Open University
Developing an International Digital Network in the History of Reading: collaboration between the UK Reading Experience Database and invited partners.
Mr D Pritchard £139,531.00
Digital Design Studio, Glasgow School of Art
Enhancing Engagement with 3D Heritage Data through Semantic Annotation
Professor JD Richards £141,771.00
Department of Archaeology, University of York
ADS+: Enhancing and Sustaining the Archaeology Data Service digital repository
Professor TP Schofield £262,673.00
Bentham Project, University College London
The Bentham Papers Transcription Initiative
Professor D Tudhope £109,802.00
Faculty of Advanced Technology, University of Glamorgan
Semantic Technologies Enhancing Links and Linked data for Archaeological Resources (STELLAR)
Dr C Watts £136,498.00
English, Birkbeck College
Voiceworks Digital Song/Text Project: a collaboration between Birkbeck Centre for Poetics, Wigmore Hall & Guildhall School of Music & Drama
Mr K Woolford (Conditional award) £487,794.00
School of Media, Film and Music, University of Sussex
Motion in Place Platform
Professor A Yarrington £61,462.00
Department of History of Art, University of Glasgow
Mobilising 'Mapping Sculpture in Britain and Ireland, 1851-1951' (Mobilising Mapping)


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Innovation Center Summer Classes
The Innovation Center is offering extended for-credit learning opportunities to high school students this summer. Students can explore the various pathways available to them at the Innovation Center. Course options offer a hands-on introduction to various fields including augmented and virtual reality technologies, cybersecurity, design, information technology, and robotics.


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Pro-Ukrainian activists prevented repairs to sabotaged power lines leading to Crimea on Monday, keeping the Russian-annexed peninsula starved of electricity for a second day and tensions between Moscow and Kyiv high.
Ethnic Tatars and members of Ukrainian nationalist battalions largely blocked access for engineers to four pylons in Kherson, a region of the Ukrainian mainland controlled by Kyiv, which unknown attackers blew up over the weekend.
"Teams are ready to fix the consequences of the blasts in the course of four days," said Igor Boska, the regional head of state power supplier Ukrenergo.
"When this can happen depends on the results of talks, which the instigators of the blockade are carrying out with authorities," he said in a statement posted on the Kherson administration's website.
Engineers began laying undersea cables from southern Russia to Crimea earlier this year to allow the contested territory, which is home to approximately 2 million people, to draw all its power from Russia by 2020.
But for now, the peninsula which Russia seized last year depends on Ukraine for at least 70 percent of its electricity and the first phase of the Russian project, which will ease dependence on Ukraine, is not due to come online until next month.
Tatar discontent
The annexation plunged relations between Kyiv and Moscow into a crisis deepened by a rebellion by pro-Russian separatists in eastern Ukraine.
One Russian senator described the blasts as an "act of terrorism." But Mustafa Dzhemilev, a senior Crimean Tatar politician, said talks to restore power to Crimea could start only after "political prisoners" on the peninsula were released, according to an interview he gave to the Ukrainian news agency Liga.
The annexation was opposed by many Tatars, a Turkic-speaking Muslim community with a long history in Crimea, and they have since held numerous protests to complain of discrimination and intimidation which they say is meant to silence dissent.
The peninsula's pro-Kremlin leadership denies a crackdown is underway.
In September, Tatar activists on the mainland set up road blocks on the two main routes leading into Crimea at the start of what they said was an economic blockade aimed at dramatizing the plight of their Tatar brethren living on the peninsula.
The activists deny they blew up the pylons, which also triggered blackouts in parts of Ukraine's Kherson. While preventing any work that would help restore electricity to Crimea, they said they would allow repairs to lines supplying mainland Ukraine.
Dmitry Peskov, a Kremlin spokesman, said Russia hoped Kyiv would take "vigorous steps" to restore Crimea's power supplies.
Russia's Energy Ministry said emergency electricity supplies had been turned on for critical needs in Crimea and that mobile gas turbine generators were being used. Sergei Aksyonov, the Kremlin-backed head of Crimea, declared Monday a non-working day because of the emergency situation.
Russia's annexation of Crimea triggered punitive Western sanctions on Moscow, which a diplomat told Reuters on Sunday would stay in place until at least July 2016.


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Instagram said Tuesday that a hate-filled manifesto linked to the El Paso shooter wasn't uploaded to the Facebook-owned photo-sharing site as suggested by the owner of a fringe message board where the document was initially discovered.
A spokeswoman for Facebook said it disabled an Instagram account tied to the suspected gunman on Saturday. The account hadn't been active for more than a year, she said.
Instagram is working with law enforcement, she said, and she directed any additional questions to the Federal Bureau of Investigation. The FBI declined to comment.
The statement comes after Jim Watkins, the owner of the 8chan message board, suggested in a YouTube video that the document had been loaded to his site by a different user. Watkins, who appeared in front of an image of Benjamin Franklin, said the site had made law enforcement "aware" of the manifesto when it appeared.
He also suggested — but didn't state — that the gunman, who killed 22 in the attack at a Walmart store, had posted the document to Instagram.
"First of all, the El Paso shooter posted on Instagram, not 8chan," Watkins said in the video. "Later, someone uploaded the manifesto. However, that manifesto was not uploaded by the Walmart shooter. I don't know if he wrote it or not, but it was not uploaded by the murderer; that is clear."
8chan, an anonymous forum, is a magnet for trolls, who delight in racist, sexist and politically incorrect humor. Watkins' video was titled "Sorry for the inconvenience, common sense will prevail" an apparent reference to the title of the 2,300-word manifesto, which was called "The Inconvenient Truth."
The House of Representatives Committee on Homeland Security's Twitter account posted Tuesday a request for Watkins to appear in front of Congress. Rep. Bennie Thompson, a Democrat from Missouri and chairman of the committee, and Rep. Mike Rogers, a Republican from Michigan, penned the letter and referenced the El Paso mass shooting as "at least the third act of white supremacist extremist violence" linked to the site.
"Experts have described 8chan as a platform for amplifying extremist views, leading to the radicalization of its users," the representatives said in the letter. "Americans deserve to know what, if anything, you, as the owner and operator, are doing to address the proliferation of extremist content on 8chan."
Since the discovery of the manifesto, 8chan has lost technical support from services such as security platform Cloudflare. The site went down early Monday. At the time, a tweet from the site's official account said it'd be down for 24 to 48 hours. 8chan isn't currently available.
Fredrick Brennan, 8chan's founder, who's no longer associated with the site, told The New York Times on Sunday that the site needs to be shut down. "It's not doing the world any good," he told The Times. "It's a complete negative to everybody except the users that are there. And you know what? It's a negative to them, too. They just don't realize it."
Earlier this year, the gunman who attacked two New Zealand mosques and the gunman who attacked a California synagogue posted their manifestos to 8chan.
Watkins and administrators for 8chan didn't immediately respond to a request for comment.
Originally published, Aug. 6, 6:59 a.m. PT.
Updates, 7:10 a.m.: Adds FBI's response; 11:43 a.m.: Includes Facebook's response; 3:28 p.m.: Reorganized, and adds letter from Homeland Security committee.


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By Nyan Lynn
Life is not easy for caregivers who have to deal with someone with Alzheimer's disease or other dementia. In addition to kindness, they also have to show their patience to their beloved ones who have memory problems and cannot do daily tasks themselves. Depending on the stage of disease, some of them even do not remember their name, their age, and those who look after them on a day-to-day basis. Most caregivers happen to be wives or daughters.
In the following video, Judy Johanson talks about her struggles in taking care of her husband, Steven Johanson. He was just 58 when he was diagnosed with Alzheimer's. In their home in Watertown, Mrs. Johanson expressed how she felt devastated in the beginning, how her husband was depressed, and how they both decided to face this disease. Sitting beside her, Mr. Johanson occasionally jumped into the conversation to support his wife.
See the video below:
When people are older, they often feel regret for what they have not done or for what they have done when they were young.
In the following video, Ann Kennedy revealed her regret. The 80-year-old lesbian has several health problems. As she has some parts of her body replaced, she described herself as a 'bionic' woman. In her room at Providence House, an assisted living facility, Kennedy talked about her health condition and her philosophy about life.
See the video below:


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UBS Securities India Pvt Ltd
Public offer of up to 181,341,058 equity shares of face value of Rs. 10 each (Equity shares) of ICICI Prudential Life Insurance Company Limited (The Company) for cash at a Price of Rs. 334 per equity share, through an offer for sale by ICICI Bank Limited (Selling shareholder), aggregating up to Rs. 6056.79 Crores (the offer), including a reservation Of up to 18,134,105 equity shares for purchase by ICICI Bank shareholders for cash at a price of Rs. 334 per equity share Aggregating to Rs. 605.68 Crores (The ICICI Bank shareholders reservation portion). The offer would constitute 12.63% of post-offer paid-up equity share capital and the Net offer shall constitute 11.37% of the post-offer paid-up equity share capital.The Offer Price: Rs.334 per equity share of face value of Rs.10 each.Anchor Investor offer price: 334 per equity share.The offer price is 33.4 times of the face value.
Money Payable On
Further Multiples of: 44
ICICI Prulife Tower Prabhadevi 1089 Appasaheb Marathe Marg Mumbai
Maharashtra- 400025
Phone - 91-22-40391600
Fax - 91-22-66622031
Email - firstname.lastname@example.com
Website - www.iciciprulife.com


text:
The Pineapple Thief have announced an 11-date European tour.
They've lined up the shows for September in support of their latest album Your Wilderness – and they'll once again be joined on the road by King Crimson drummer Gavin Harrison and Godsticks guitarist Darran Charles.
Harrison and Charles previously played with the band on their winter dates earlier this year.
The Pineapple Thief leader Bruce Soord says: "We can't wait to get back on the road again! Personally, I am really excited that people will have another opportunity to see and hear this fantastic lineup.
"Darran and Gavin have brought a whole new dimension to this band."
They'll will perform Your Wilderness in full, along with a variety of reimagined tracks from their back catalogue. The shows will also mark the last of the year for the band.
Support will be provided by Charles and his Godsticks bandmates.
Find a full list of The Pineapple Thief's tour dates below.
- New Issue Of Prog On Sale Today
- Watch Nad Sylvan's video for When The Music Dies
- Muse will release new single Dig Down next week
- Read Classic Rock, Metal Hammer & Prog for free with TeamRock+
The Pineapple Thief 2017 European tour
Sep 06: Dresden Alter Schlachtof, Germany
Sep 07: Warsaw Progesja Music Zone, Poland
Sep 08: Krakow Kwadrat Music Club, Poland
Sep 09: Brno Melodka, Czech Republic
Sep 10: Munich Backstage Halle, Germany
Sep 11: Zurich Dynamo, Switzerland
Sep 12: Stuttgart Universum, Germany
Sep 13: Cologne Luxor, Germany
Sep 14: Zoetermeer De Boerderij, Netherlands
Sep 16: London ULU, UK
Sep 17: Bristol Bierkeller, UK
"F**k you, I'm Bruce Soord!" Have The Pineapple Thief become rock stars?


text:
Poki Time
177 Southgate Ave, Daly City, CA 94015
(650) 550-4244
(650) 550-4244
MenuHere is the menu for Poki Time.
Why Visit Us
The tastiest poke restaurant in Daly City is Poki Time, 1000%. If you've never eaten there before, then why are you still not there? Step right in and try a poke meal that you won't soon forget. They're located at 177 Southgate Ave. Awesome, 4.8 stars! No other place is better in 94015.


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Assemble all the important thing constituents (that's often a enterprise companion or different govt workforce members if relevant). Purchaser personas are a good way to define your audience by means of demographics, tasks, and interests. A buyer persona executed effectively gives you a goal and path. Plus, these personas may be utilized to section your record and better personalize your product sales and promoting messages. These breakdowns usually are introduced as a grid, with bullet factors in every part breaking down most likely probably the most associated information—so you'll be able to most likely skip writing full paragraphs right here. Strengths and weaknesses—both interior agency elements—are listed first, with options and threats following within the next row. With this visual presentation, your reader quickly can see the constructive and damaging inside and exterior components that may impression your small business.
In month-to-month night time classes the discussion board evaluates the enterprise plans of companies accepted for presentation during 60- to ninety-minute segments in which no holds are barred. The format permits each presenter 20 minutes to summarize a marketing technique orally. Each panelist opinions the written advertising technique upfront of the classes. Then each of four panelists—who're enterprise capitalists, bankers, promoting and advertising specialists, successful entrepreneurs, MIT professors, or different consultants—spends 5 to ten minutes assessing the strengths and weaknesses of the plan and the enterprise and suggesting improvements.
Starting a espresso store? Are you a free service?
Too many entrepreneurs, though, proceed to consider that within the occasion that they build a larger mousetrap, the world will beat a path to their door. An excellent mousetrap is important, nevertheless it's solely part of meeting the challenge. Additionally vital is satisfying the needs of marketers and traders. Entrepreneurs have to see proof of purchaser interest and a viable market. Consumers have to know once they can money out and the way good the financial projections are. Drawing on their own experiences and folks of the Massachusetts Institute of Expertise Enterprise Discussion board, the authors show entrepreneurs simple strategies to write convincing and profitable enterprise plans.
Doing this won't yield any consequence.
Regardless of the size of your small business, social tools can help you better join collectively along with your viewers, attain new potential clients, and improve consciousness of your model. If the probabilities seem overwhelming, start small. Not each business launches with a proper advertising and marketing strategy, however many founders discover price in taking time to step back, research their thought and the market they're in search of to enter, and perceive the scope and the strategy behind their methods. They've created merchandise & services we have all heard of, turned total industries the fallacious approach up, redefined what it means to achieve success as soon as you start a enterprise and loads of have also written enterprise books or taught on-line enterprise courses about it. Suffice it to say, their business suggestion is worth its weight in gold.
Then, they have been ready to manufacture cars for a fraction of what American assembly traces might. In case you're merely starting a enterprise , you want a business plan. In some methods, your advertising and marketing technique is your roadmap—it not solely guides you and totally different key stakeholders as you develop your enterprise, but it certainly also exhibits patrons, lenders, or potential partners the place your on-line business is headed.


text:
21 Jun Putting Net Zero by 2050 in Perspective — Be Prepared to Walk by Yves Siegel, CFA
In Our View: The IEA's Energy Transition Pathway to Net Zero Emissions by 2050 is Highly Uncertain
In May, The International Energy Administration (IEA) released, "Net Zero by 2050, A Roadmap for the
Global Energy Sector." This detailed report highlights one possible pathway to achieve global net-zero
emissions by 2050 and limit the long-term increase in average global temperatures to 1.5 degrees Celsius.
This herculean (or "impossible," according to some skeptics) task "requires all governments to
significantly strengthen and then successfully implement their energy and climate policies." The IEA
report grabbed headlines for noting in its roadmap that to achieve the targeted emissions goals, there
should be no new investments in oil and gas exploration projects starting in 2021. Under this scenario, oil
and natural gas demand would fall by about 50% and 75%, respectively, by 2050. Fossil fuels' share of
energy supply would fall from about 80% to 20%. Solar will become the dominant source and account for
about 20% of energy supply. OPEC's market share of a shrinking pie would grow from about 37% to 52%.
To be fair, the IEA acknowledges that this road to net-zero emissions is uncertain and additional pathways
may need to be considered. We agree.
Globally, we're moving in the right direction.
Click link to continue reading…


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A look at Kanye West's strange plans to build the Wyoming home of his dreams
In September, West reportedly purchased a 9,000-acre ranch in Cody known as Monster Lake Ranch. It was most recently listed for $14 million, though the final price paid by the rapper is unknown. Real Estate News & Insights | realtor.com®.#foridanews #fidelityhomegroup #floridakeysmortgage


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We help strengthen the resilience of critical infrastructure with proven solutions and the most comprehensive platform to manage risk, protect infrastructure and promote safety. Our industry expertise goes deep and our solutions work the way you need them to — no more sacrificing field efficiency, compromising employee safety or adapting your workflows to fit the platform.
The demo helps you take a deeper dive into the damage prevention, asset protection and risk management solutions of our platform.
Learn how our solutions can help you:
Are you ready to see our platform in action? Request a demo of UtiliSphere today.
Irth Solutions' market-leading SaaS platform improves resilience and reduces risk in the sustainable delivery of essential services that millions of people and businesses rely on every day. Energy, utility and telecom companies across the U.S. and Canada trust Irth Solutions for damage prevention, asset protection and risk management solutions, making Irth the top provider for 811 (one call) ticket management and utility locating software since 1995. Powered by business intelligence, analytics and geospatial data, our platform helps deliver the 360-degree situational awareness needed to proactively mitigate and manage risk of critical network infrastructure in a changing environment.


text:
React & TypeScript Chrome Extension Development [2022]
Learn Google Chrome Extension development using modern web frameworks. JavaScript, React, TypeScript, Webpack and more!
What you'll learn
The ins and outs of Chrome Extension development in 2022
Deploying your completed extension to the Chrome Web Store for real users
Standard extension development in basic HTML, CSS and JavaScript and modern development in React and TypeScript
Design a build system for developing extensions using Webpack
Build user interfaces using popular component libraries like Material UI
Using HTTP requests in your chrome extensions to interact with third party APIs
Work with simple command line tools such as Git and NPM
Learn to use Manifest Version 3 Chrome APIs, newly released in 2021
Build a multi-featured weather extension built in React, TypeScript and Webpack
Design an ad blocker extension that covers the basic principles of ad blocking
Create a study focus timer extension built in simple JavaScript, HTML and CSS
Build a mini TV show search extension and text-to-speech extension
Bonus mini-section covering the basics of Chrome Extension themes
Basic understanding of JavaScript, HTML, CSS for standard extension development
Basic knowledge of React for modern frameworks section
Hi! Welcome to the comprehensive Chrome Extension Development course using modern web frameworks in 2022. This is the only course on Udemy that is focused on building extensions using modern technologies like TypeScript, React and Webpack along with standard JavaScript and HTML/CSS development. Using popular frameworks means that the skills you learn in this course building extensions will be transferrable to general web software development.
The course is designed flexibly for students of all levels, covering everything from the very basics of extensions to more exciting new technologies! The first part of the course is designed to help you hit the ground running so that you can develop your very first extension within the first hour of the course. Then, we begin introducing more advanced concepts, technologies and projects to supercharge your extension development skills.
Throughout the course we cover a ton of concepts and technologies:
- Comprehensive overview of the fundamentals behind Chrome Extensions
- Building extensions using the standard approach with JavaScript, HTML and CSS
- Designing a Webpack build system to enable the use of React and TypeScript in your extension
- Basic usage of Git and NPM on the command line
- Using design system component libraries like Material UI to build beautiful UIs quickly
- Building three large extension projects step-by-step from scratch
- Data fetching using HTTP requests to third party APIs
- Deploying your completed extension to the Chrome Web Store for real users
If you have any additional questions, please let me know. I'm always happy to help.
Register today to see what modern Chrome Extension development can look like!
Who this course is for:
- Anyone curious about learning to build Chrome Extensions using modern web frameworks
- Perfect for developers of all skill levels looking to expand their web development skills to Chrome Extensions
- If you want to take ONE course to learn everything you need to know about chrome extension development, take this course
Created by Jason Xian
Last updated 4/2022
English [Auto]
Size: 4.21 GB


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Bedtime Prayer (for men)
As I lay me down to sleep
I pray for a woman who's very cheap.
One who's sexy, blonde and long.
Who notices that she's mostly wrong.
One who sucks and doesn't speak.
And promises to do so at least once a week.
I pray that she is very randy,
'cause one like that would come in pretty handy.
Opens her legs and lies on the floor,
and once I'm done, she wants no more.
Oh, send me a woman who will not play with my mind.
Who knows what she wants and that's a LOT from behind!
One who'll screw till my body's a twitchin'
and brings me a beer when she comes from the kitchen!
I pray that she'll last right up to the end,
And would never complain when I do her best friend.
Thanks in advance and you know I can't wait,
so I'll screw all the rest 'cause it's never too late.
Bedtime Prayer (for women)
I pray for a man who's not a creep.
One who's handsome, smart and strong.
He's not afraid to admit it when he's wrong.
One who thinks before he speaks.
When he promises to call,
he doesn't wait 6 weeks.
I pray that he is gainfully employed
and won't lose his cool when he's annoyed.
Pulls out my chair and opens my door,
massages my back and begs to do more.
Oh, send me a man who will make love to my mind.
Knows just what to say when I ask, "How fat is my behind?"
One who'll wake love till my body's a twitchin'.
He brings ME a sandwich too, when he goes to the kitchen!
I pray that this man will love me to no end,
And would never compare me with my best girlfriend.
Thank You in advance and now I'll just wait,
for I know You will send him before it's too late.
"Yes, Nurse Tracy," said Mr. Goldstein, "My penis died today, and I am very sad"
Knowing her patients were forgetful and sometimes a little crazy, she replied, "Oh, I'm so sorry, Mr. Goldstein, please accept my condolences.
The following day, Mr. Goldstein was walking down the hall with his penis hanging out of his pajamas, when he met Nurse Tracy. "Mr. Goldstein," she said, "you shouldn't be walking down the hall Like this. Please put your penis back inside your pajamas."
"But, Nurse Tracy," replied Mr. Goldstein, "I told you yesterday that my penis died."
"Yes, you did tell me that, but why is it hanging out of your pajamas?" asked Nurse Tracy.
"Well," he replied. "Today's the viewing."
The woman says: "I will surely miss you"
[Adultjokes.fi] [Shop] [Funny videos] [Contest] [Links]
frank (at) dlc.fi


text:
Eighty-seven cases of occupational asthma induced by toluene diisocyanate (TDI) were diagnosed by an inhalation challenge with TDI and methacholine. After an average follow-up interval of 11 yrs, all subjects were re-examined.
Of the 87 subjects examined, 13 (15%) had remained in the same job, 44 (50.5%) had been removed from exposure for <10 yrs and 30 (34.5%) had been removed for >10 yrs. The proportion of subjects who experienced symptoms of asthma and those who were hyperresponsive to methacholine was significantly lower. Of the patients, 59% used short-acting bronchodilators, 8% long-acting bronchodilators and 18% were on regular inhaled glucocorticoids. Thus, multiple regression analysis showed a positive correlation between forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) at follow-up and FVC and FEV1 at diagnosis, and a negative correlation with smoking and with therapy with bronchodilators. Stepwise logistic regression showed that the follow-up provocative dose causing a 20% fall in the FEV1 (PD20) could be predicted from baseline PD20.
These results indicate that respiratory symptoms and airway hyperresponsiveness to methacholine persist in subjects removed from exposure to TDI for >10 yrs. A more favourable prognosis was associated with a better lung function and a lower degree of airway hyperresponsiveness to methacholine at diagnosis.
This study was supported in part by grants from MURST (60% and 40%), A.R.C.A. and Consorzio Ferrararicerche.
Diisocyanates, widely used and highly reactive industrial chemicals, are among the most frequent causes of occupational asthma (OA) in industrialised countries 1. The most commonly used diisocyanate is toluene diisocyanate (TDI), a mixture of 2,4 and 2,6 isomers (80:20). The precise mechanisms underlying isocyanate-induced asthma are unknown, even though the immunological mechanism remains the likeliest occurrence, with its latency interval between exposure and onset of asthma 2. In terms of long-term outcome, despite complete avoidance of exposure, Park and Nahm 3 showed a spectrum of responses in subjects with isocyanate asthma and proposed that the final outcome depends on which mechanism is predominant in each individual. The majority of the follow-up studies on isocyanate asthma 4–11 emphasised that only one-half of subjects with isocyanate asthma will recover, while one-half of those who do not recover will show some improvement, and one-half will complain of asthmatic symptoms and will require anti-asthma therapy. Short duration of exposure to isocyanates and of symptoms before the diagnosis, immediate cessation of exposure after diagnosis, young age, milder degree of nonspecific airway hyperresponsiveness and presence of specific immunoglobulin (Ig)E antibodies to isocyanates have been found to be associated with a favourable prognosis.
In the present study, the results of a follow-up examination on 87 subjects sensitised to TDI are reported. The phenotype characteristics of the subjects are illustrated in order to investigate the outcome of disease. Since OA is a valid model of adult-onset asthma 12, 13, information on the outcome of OA can also bring new insights into the natural history of non-OA.
Eighty-seven subjects with a history of asthma induced by exposure to TDI were studied. None of these subjects had symptomatic asthma before occupational exposure to TDI or had been subject to exposure to isocyanate spills in the past. All subjects were asked for a detailed clinical and occupational history, and underwent skin-prick tests with a battery of common allergens and pulmonary function tests. All subjects had been free of respiratory infections or exposure to isocyanates for at least 2 weeks. No subject had taken cromolyn, theophylline, sympathomimetics or antihistamines within 48 h of any study. Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were measured using a dry bellows spirometer (Model 840; Ohio Air Co., Houston, TX, USA). The isocyanate inhalation test was carried out in all subjects at the time of diagnosis. The methacholine inhalation challenge was performed at diagnosis and at a follow-up visit, as previously described 14. Thirty subjects did not perform the inhalation challenge with methacholine at follow-up for the following reasons: 18 exhibited airway obstruction, two had expiratory wheezes at chest auscultation, seven had hypertension, one was breastfeeding, one had paradoxic bronchoconstrictor response to bronchodilators and one refused to perform the challenge. The instruments, methods and technicians were the same at diagnosis and the follow-up visit.
Data analysis
An asthmatic reaction to TDI was considered to occur when FEV1 decreased by at least 20% from baseline. Airway obstruction was defined as FEV1/FVC ratio <75% according to the criteria established by the American Thoracic Society 15. To assess airway responsiveness, the cumulative dose of methacholine producing a 20% fall in the FEV1 (PD20) was calculated by interpolation from the dose/response curve and was used as a measure of airway responsiveness.
The following statistical analyses were carried out: frequency distribution, Kolmogorov-Smirnov nonparametric test for normality, nonparametric test of Mann-Whitney, Chi-squared test, correlation, and multiple regression analysis. Since distribution of methacholine was highly skewed, log10 transformation was used for statistical analysis and values were reported as geometric means.
A stepwise logistic regression was performed to evaluate the effects of potential factors (independent variables: baseline responsiveness (log PD20), duration of exposure (yrs), length of follow-up (yrs), absence or presence of current inhaled glucocorticoids on the follow-up airway responsiveness abnormal PD20 (≤1 mg versus normal PD20 >1 mg) (dependent variable). Length of follow-up was put into the model as a continuous or categorical (≥10 yrs, <10 yrs) variable.
A p≤0.05 was considered to be significant.
The clinical features of the subjects at the time of diagnosis and of the follow-up visit are shown in table 1⇓. There were 63 males and 24 females included in the study. A small proportion of the subjects were smokers and atopics, features that did not change at the follow-up visit. The average duration of exposure to TDI was 12 yrs. The majority of workers (>70%) were employed in furniture factories or carpentry shops. At follow-up visit (average duration of follow-up±sem: 11±0.4 yrs), 15% of the subjects continued to remain exposed to TDI, whereas 85% had been removed from exposure. Of those removed from exposure, 34.5% had been removed for >10 yrs. There was a significant difference with regard to the presence of symptoms of asthma and of airway hyperresponsiveness to methacholine between the two visits, with a lower percentage of symptomatic (71 versus 100%) and hyperresponsive subjects (25 versus 62.5%) at follow-up (p<0.001). When subjects were examined according to the interval since removal from exposure, respiratory symptoms occurred in 84.6% of subjects exposed to TDI, in 75% of those removed for <10 yrs (p<0.001) and in 60% of those removed for >10 yrs (p<0.01). PD20 methacholine was lower in subjects exposed to TDI at follow-up (geometric (G) mean (Gsem) 0. 855 mg (1.46) versus 1.045 mg (1.15) in subjects removed for <10 yrs and 1.173 mg (1.18) in those removed for >10 yrs. The degree of airway responsiveness was milder at follow-up examination. At diagnosis, 35.6% of subjects with a positive inhalation challenge to methacholine had a PD20 <0.300 mg, whereas at follow-up the percentage of subjects highly responsive to methacholine was 8.9%. At follow-up visit, 59% of the subjects used inhaled short-acting bronchodilators, 8% used long-acting bronchodilators and 18% used inhaled glucocorticoids. At the time of the diagnosis, specific inhalation challenge with TDI in the laboratory elicited an immediate asthmatic reaction in 20.7%, a late reaction in 54% and a dual reaction in 25.3% of the subjects. At the time of the follow-up examination, there was a significant difference in FVC (% predicted) and PD20 methacholine, as compared with values obtained at diagnosis (table 2⇓) 16. Among subjects exposed to TDI, 33.3% at diagnosis and 37.9% at follow-up exhibited airway obstruction. At follow-up examination, the lung volumes FEV1 (L) and/or FEV1 % pred, and FVC (L) and/or FVC % pred, and PD20 methacholine showed a negative correlation with the duration of exposure to TDI, but the correlations were significant only for subjects exposed to TDI. Spearman's rank correlations were −0.70, p<0.01; −0.65, p<0.05; −0.55, p<0.05; −0.49, 1<p<0.05; and −0.60, p<0.05, respectively.
Multiple regression analysis showed that follow-up FEV1 (% pred) and FVC (% pred) values could be predicted from those at diagnosis. At the time of follow-up examination, FEV1 and FVC were significantly lower in smokers (B=−6.38, p<0.005 and B=−5.53, p<0.005, respectively), whereas atopy was associated with a better lung function (B=4.64, p<0.05 and B=5.21, p<0.001, respectively). FEV1 (% pred) was lower in symptomatic subjects (B=−7.61, p<0.005). The results of the stepwise multivariate logistic regression are shown in table 3⇓. In all models, PD20 at diagnosis was a significant predictor of follow-up PD20, a lower degree of airway hyperresponsiveness to methacholine at diagnosis being associated with a lower risk to be hyperresponsive at follow-up. The duration of exposure, the interval since removal from exposure and the current treatment with inhaled glucocorticoids were predictors of the responsiveness to methacholine at the follow-up visit, but the significance was borderline (p=0.06, p=0.08 and p=0.06, respectively).
In this study the clinical picture of 87 subjects with TDI-induced asthma and the outcome of the subjects at follow-up examination are described. The outcome of isocyanate-induced asthma has been investigated previously 3–11. However, this study offers additional interest. Indeed, the population was rather large, had been exposed to the same chemical, i.e. TDI, was employed in workplaces with similar characteristics, the diagnosis was made by specific inhalation challenge in 100% of the cases and the follow-up time was long. Thus, the study offers the opportunity to further characterise the natural history of a very common type of OA and to improve the understanding of the natural history of adult-onset asthma.
This study confirms the features of isocyanate asthma. The latent period between onset of exposure and onset of symptoms is prolonged, the proportion of atopic subjects and of current smokers is low, and the late asthmatic reaction is very common. Interestingly, the proportion of atopic subjects and current smokers did not change at follow-up visit, suggesting the absence of an increase in atopic status after many years from the diagnosis of OA caused by a low molecular-weight agent such as TDI. Even though a lower percentage of symptomatic subjects at follow-up examination was observed, they were subjects that had been removed from exposure, not subjects who continued in their primary workplace. However, it should be noted that 60% of subjects removed for >10 yrs complained of asthmatic symptoms and ∼60% of workers needed therapy with bronchodilators, whereas ∼20% of subjects used inhaled glucocorticoids.
These findings confirm the poor clinical outcome of TDI-induced asthma and are in agreement with the results of Piirila et al. 11. Recently, these authors performed a long-term follow-up study on subjects with isocyanate-induced asthma. They examined 95 subjects with hexamethylene diisocyanate (HDI)-, 96 subjects with diphenylmethane diisocyanate (MDI)- and 42 subjects with TDI-induced asthma (17% of the subjects). They found that the persistence of symptoms was mostly associated with TDI-induced asthma, a link confirmed by the finding that TDI patients used more medication than patients with HDI- and MDI-induced asthma. In the study by Piirila et al. 11, the worsening of lung function could be linked to the high percentages (74 and 60.5%) of smokers at diagnosis and at follow-up, whereas in the present study, even though a deleterious effect of smoking on lung volumes at follow-up examination was found, it is emphasised that the percentage of smokers was very low (8 and 6.9% respectively at diagnosis and at follow-up). Another potential mechanism for the worsening in lung function observed by Piirila et al. 11 is the possibility that active cigarette smoking impairs the efficacy of short-term inhaled corticosteroid treatment in mild asthma 17.
In agreement with previously reported findings 18, 19, it was shown that level of airway responsiveness to methacholine at time of diagnosis is a predictor of the persistence of airway hyperresponsiveness. Perfetti et al. 18 examined subjects with OA due to both high and low molecular weight agents and found that subjects removed from exposure for >5 yrs showed better prognostic figures than those reported in most follow-up studies up to 5 yrs after cessation of exposure, showing that the majority of subjects were symptomatic and hyperresponsive to methacholine.
The present study confirms, at least in part, these findings. Even though the level of significance was borderline, it was also shown that the duration of follow-up (for >10 yrs) is a factor that affects airway responsiveness to methacholine. At follow-up examination, a lower proportion of subjects exhibited airway hyperresponsiveness and a lower degree of hyperresponsiveness was observed in the group removed from exposure for >10 yrs. In the present study, the effects of methodological problems were avoided by ensuring instruments, technicians and protocols for delivering methacholine were the same at both diagnosis and follow-up visits. However, it must also be emphasised that a large part (60%) of the group of subjects removed for >10 yrs complained of asthmatic symptoms and that the lung volumes were significantly lower at follow-up after adjusting for age.
The present study did not allow evaluation of the use of anti-inflammatory drugs for asthma and of inhaled long-acting bronchodilators for asthma started at diagnosis. In many cases, the medication had been discontinued and, in addition, the regular use of inhaled steroids and long-acting bronchodilators has become common only in the last decade. The use of these drugs could only be accounted for at the follow-up visit. As expected, subjects who used long-acting bronchodilators had lower lung volumes and subjects who used inhaled steroids had a lower degree of airway hyperresponsiveness to methacholine.
The type of asthmatic reaction did not have a prognostic value in the present study. The influence of the type of reaction on the outcome has been controversial 4, 5. In a previous study, the authors suggested that the late reaction and the severity of the reaction could be related to the persistence of sensitisation to isocyanates 7. At variance with this study, the larger size of the population sample examined here and the long follow-up time allow the authors to conclude that the type of asthmatic reaction is not an important predictor for the persistence of the disease. More recently, evidence has been presented that the outcome of specific airway responsiveness to occupational agents may be different from the outcome of nonspecific airway responsiveness 19.
Among the many risk markers associated with susceptibility for the development of TDI asthma, the ability to cope with oxidative stress has been studied recently 13. Evidence has been presented that TDI exposure might cause oxidative stress at the epithelial surface 20. Defects in antioxidant defences could contribute to both the susceptibility of sensitisation and the persistence of TDI-induced asthma. To support this hypothesis, a critical role for the glutathione-S-transferase locus (GSTP1) gene product has been demonstrated recently 21. Homozygosity for the Val105-encoding alleles confers protection against the development of the asthma-associated phenotype airway hyperresponsiveness and the protective effect increased in proportion to the duration of exposure to TDI.
In conclusion, the present study showed a poor prognosis of toluene diisocyanate-induced asthma. The long-term follow-up revealed that both asthmatic symptoms and airway hyperresponsiveness to methacholine persisted or improved slowly for >10 yrs after the workers left the workplace and ceased being exposed to isocyanates entirely. A more favourable outcome was associated with a better lung function, a lower degree of airway hyperresponsiveness to methacholine and a longer interval from cessation of exposure.
The authors would like to thank the subjects who participated in this study. They would also like to thank F. Parise for her valuable contribution in revising the manuscript.
- Received July 9, 2002.
- Accepted November 29, 2002.
- © ERS Journals Ltd


text:
New York City
Acclaimed author Chaim Potok transports us to a world completely strange, yet strangely familiar. This story of two fathers and their two teen-age sons unfolds amid a bustling Jewish neighborhood in 1944 Brooklyn. One Hasidic and the other Orthodox, the boys prove catalysts for one another's transition to manhood along parallel spiritual and familial struggles. At the center of it all rests not only the uncompromising mystery of being chosen, but also the extraordinary choices we must all make to fill our lives with meaning.


text:
We are a friendly family of believers impacting lives in our community and the world.
We are a friendly family of believers here at Springfield Fellowship. Our purpose is to impact lives in our community and throughout the world by helping individuals discover and grow in a personal relationship with God through Jesus Christ our Lord and Savior.
To accomplish our mission, we strive to provide:
-The Truth of God's Word
-Inspirational worship opportunities
-A variety of educational programs for all ages
-Creative opportunities for serving, giving and evangelism
-An atmosphere of encouragement and fellowship
As you have therefore received Christ Jesus the Lord, so walk in Him, rooted and built up in Him and established in the faith, as you have been taught, abounding in it with thanksgiving.
Colossians 2:7
Sunday Services:
Sunday School for all ages – 9:45 AM
Worship Service – 10:45 AM
Children's Church
Wednesday Services:
11:00 a.m.
Adult Bible Study
6:30 p.m.
Adult Bible Study
Kid's Bible Club Pre School thru 5th Grade
Warrior's 6th Grade and Up
Monthly Men's Group
the Second Saturday morning at 9:30 a.m.
Monthly Women's Bible Study
the Second Saturday morning at 9:30 a.m.


text:
Fekvenyomó Európa-bajnokság2022. augusztustus 2-7.
Fekvenyomó Európa-bajnokság2022. augusztustus 2-7.
Versenyhelyszín:Budapest Kongresszusi Központ
Bench Press Championships2022. august 2-7.
Competition venue:Budapest Congress Center
Budapest Congress Center is the most complex event facility in Budapest. It has over 20 meeting rooms in various shapes and sizes, adjustable for every possible need, as well as an exhibition space of over a 4000 m2, which means it can hold separate events at the same time without them interfering with each other.
1123 Budapest, Jagelló street 1-3.
GPS - 47.4886, 19.0220 // (map)
They offer impeccable hostess, security, catering services and their meeting rooms equipped with up-to-date furniture, reliable audio-visual equipment, and projection screens up to 96 m2 and, in addition to that, Pátria and Bártok meeting rooms have built-in translation booths for interpreting services.


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The SDG Tellis post has over two years of testing and development, and lacks the shortcomings of many other posts on the market. The Tellis is very simplistic, and functions with a sealed hydraulic cartridge system that is extremely durable. The Tellis post comes with a two year warranty, and SDG's soft action lever.
Cable Routing: Internal
Rail Compatibility: 7 x 7mm (Steel, Chromoly, Titanium) or 7 x 9mm (Oval Carbon)
Minimum Insertion: 107mm
Material: Aluminum
Color: Black
This product was added to our catalog on May 9, 2019


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About Us
About Us
Bridge Community Church
500 E. North Island Dr
Shelton, WA 98584
(360) 426-6352
To Know Him & To Make Him Known
Sunday Services
Adult Bible Study: 9:30 a.m
Nursery Care: 10:30 a.m.
Worship Service: 10:30 a.m.
Children's Church: 11:00 a.m.
We Have Had
On Our Site
To View The Latest Updates, click HERE
Attendance in Worship on September 24, 2023
84 Adults
8 Children & Youth
Click HERE to see
what's new on the site
Click HERE for Directions To The Church
Dear Friend,
Welcome to the Bridge Community Church Website
Thank you for taking time to view all that our church has to offer. We are a fellowship of people who have been transformed by the love of our Lord Jesus Christ, His sacrifice for us, and His life in us. The best way to find out Jesus can transform your life is to comefor a visit and see for yourself! are a small church located on Harstine Island, about 12 miles north of Shelton, Washington. We were founded in 1996 and worshiped in the Harstine Island Community Hall until our new church building was completed in 2009. We are the only church on the island. Our congregation is made up of people from many Christian traditions, yet we find unity in our relationship with God. We hope you will find that we are a church where the Holy Spirit and the love of Christ is present in our worship, fellowship, prayer, Bible studies and our various ministries.
We sincerely hope you will join us on Sunday mornings at 9:30 a.m. for adult or teen Bible study, and at 10:30 a.m. for a refreshing time of worship and study of God's word. We look forward to meeting you and answering any questions you may have.
All are welcome at Bridge Community Church and we look forward to your visit! The best way to find out how Jesus can transform your life is to comefor a visit and see for yourself!
Pastor John Martin and all the congregation at Bridge Community Church.


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Xyz , 18 May 2017It was such a lovely phone but got destroyed by this 7.1.1 update....volte stopped working now... moreSuch a nice phone, but I can't get a replacement battery, please help out.
It was such a lovely phone but got destroyed by this 7.1.1 update....volte stopped working now only if its not connected to a Wi-Fi network and Reliance jiovoice4g is not installed it will not work now.....in order to use volte one has to install jiovoice4g from app store to use it ....battery that was the main feature of this phone also started draining faster ..
Ng, 16 May 2017Over the Horizon still have many device / region not receive 7.0 update.My friends' Galaxy J3 2016 and J5 2016 are guaranteed to receive Nougat update.
My Zenfone Max shares the same hardware as the J5 2015 - SD410, 2GB RAM.
Google's premise is a 2-year guaranteed OS upgrades.
The J3 2016's hardware is far inferior to my Zenfone Max.
Other than Asus not feeling the plan of releasing Nougat to my device, there is absolutely no reason for my phone to not get it at all. But I'm gonna forgive it right now - my sister's LG G4 hasn't received the update yet either, but is surely guaranteed to receive it.
At least maybe some official confirmation from Asus that my phone would receive the update will be able to tolerate my impatience, and I'm expecting more changes for a fact that Marshmallow brought almost nothing new to my device.
this update is wrost because in this update not a boat call
After the update I also cannot make a volte call. Is there any way back that I can uninstall the update?
Just downloaded the update after reading about it here on my ZenFone 3 max ZC553KL ....After downloading it I feel the battery drain is faster than normal...anyone else experience the same thing ??
What about the bloatwares? Were they updated too?
i update my zenfone 3 max last night,after an update i cannot connect to my pocket wifi..
GrumpyHumpyBrother, 16 May 2017Shame of such late release. Android O is over the horizon. Better they update my Zenfone Max,... moreOver the Horizon still have many device / region not receive 7.0 update.
Actually is Zenfone 3 Max (ZC553KL) get Android 7.1.1 update. The Zenfone 3 Deluxe (ZS550KL) is not true.
how about go 5.5 ?
I own zenfone 3 max; however, I was not able to download the latest update. I don't know why. Could you please help me on how to update my unit? Thanks
i just updated my zenfone 3 ze552kl to nougat 7.1.1 today. got the notif yesterday.
Shame of such late release. Android O is over the horizon.
Better they update my Zenfone Max, or else I'll switch to others.


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Toy Story 4 is sure to warm our hearts and probably wet our eyes when it releases to theaters on June 21st. We have been following Woddy, Buzz, and the rest of the gang for quite some time now. These Toy Story 4 Activity Sheets are the perfect way to get ready for the gang's return to the big screen!
Toy Story 4 Activity Sheets
I just love these coloring sheets showcasing some of the classic Toy Story characters as well as some new ones. There is also a memory game and dot-to-dot.
- Woody Coloring Page
- Buzz Coloring Page
- Bo Peep Coloring Page
- Jessie Coloring Page
- Rex Coloring Page
- Aliens Coloring Page
- Ducky & Bunny Coloring Page
- Duke Caboom Coloring Page
- Gabby Gabby Coloring Page
- Ducky & Bunny Connect the Dots
- Toy Story 4 Memory Card Game (Tip: print on card stock for more durable play and/or laminate)
Along with the fun Toy Story 4 Activity Sheets, Disney shares with us 2 road trip Toy Story 4 recipes since Bonny is taking a road trip in this adventure.
What is Toy Story 4 About?
The official boilerplate: Woody has always been confident about his place in the world, and that his priority is taking care of his kid, whether that's Andy or Bonnie. So when Bonnie's beloved new craft-project-turned-toy, Forky, declares himself as "trash" and not a toy, Woody takes it upon himself to show Forky why he should embrace being a toy. But when Bonnie takes the whole gang on her family's road trip excursion, Woody ends up on an unexpected detour that includes a reunion with his long-lost friend Bo Peep (voice of Annie Potts).
After years of being on her own, Bo's adventurous spirit and life on the road belie her delicate porcelain exterior. As Woody and Bo realize they're worlds apart when it comes to life as a toy, they soon come to find that's the least of their worries.
I think the series of events is similar to the other Toy Story movies. Woody ends up lost and needs to save and or rescue another toy. Even though the story events are similar, Disney/Pixar has always done an excellent job telling us a new story. I had thought that the story was done but I am looking forward to the next adventure with our toys!


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Mascara swirling down her face,
the woman with sagging eyelids
stands on the chipped concrete
like the tall factory pipe
connected to the power plant machines.
She doesn't think about her plight,
only the fact that she must make the ends meet
in order to feed her 2 children.
"The Serpent: Smog in the City" and "To Soy, My Soul"
Mascara swirling down her face,


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"I tried to gathered the best experts to create exceptional and unique pieces. You will never see the same detail on another piece and all work is executed by master hands."
From design to fabrication, today, all is done in the same factory.
As such, you will find all necessary trades to manufacture such exquisite details, crafted each piece individually and by hand by our experienced artisans (that go from cabinetmaker to turner miller).
Whom have specialized in the handling of rare and precious materials, such as: Malachite, Lapis Lazuli, Brass and Wood.
The Patineur
He finalises and gives the object, its color and its final appearance through a process of a treatment of the surface or by oxidation of the metal, a complex alchemy.
He heats the metal by applying chemical salts to it, to accelerate nature aging until the desired shade on all part of the sculpture, which he will then fix with the wax. He is in direct collaboration with the sculptor.
The stone workers
Malachite and lapis. That work consists on shaping and cutting precious or semi-precious stones. He chooses the colors of the rough stone and the cup, then he cuts it into thin strips and removes all impurities. These pieces of strips are assembled like a puzzle, to finally be sanded and polished for a final effect.
The Founders
He creates the moulds into which hot wax is injected. Then, coated with successive layers of bronze, they are putted in the oven to completely melt the wax. After that, the bronze is putted for serval hours in another very high temperature oven.
For the realization of the moulding, the foundry uses different techniques: sand or wax moulding. As the sand
moulding technique is getting very rare over the world, we are contributing to its lasting.
The Engravers
It sculpts, incises or digs using tools on the raw mouldings to bring out all the reliefs and details in order to
give back the identity of the object.
He works on the effects of the materials and the grain, as that mattes and glosses take their effects after the gilding. It transcribes the soal of the work created by the artist.
The Guilders
Specialist in gilding application, depending on the support, the techniques are different and require a lot of operation (bath, electrolysis, mercury), to make the surface alive and be able to brown it with 24 carats Gold.
Then come the finishes such as the Brunishing, a process that gives gold its brilliance.
In 1989 working for different museums (Royal Castle in Warsaw and Hemitage in St Petersburg), I employed their best specialists : engravers from Warsaw and malachite stone workers from St Petersburg, all working according to the methods of the 18th century. These Masters have trained apprentices. This is how we have the best specialists in these fields, and they continue to pass on their know-how to new employees.
The Malachite is a semi-precious stone from the Democratic Republic of Congo. Used in jewelry but also
as decoration (vases, columns, clocks, furniture) especially in Russia from the 18th century. It is good for the health to wear it as a bracelet for its anti-rheumatic medicinal properties. We are glad to be able to work on a stone that's getting harder to find every year.
The Lapis is a semi-precious stone from Afghanistan. It is used since high antiquity (Tutankamon's sarcophagus) as well as in jewelry. From the 18th century, it started to be use for furnitures, vases, clocks, and different objects.
The Brass is a yellow copper-based alloy. It is used in foundry for clocks, statues, chiseled furnishing objects or in profile form.
The Gold is one of the most wanted material in the world. We are using it in almost all our creations. According to the countries, and the value it has different titles: 9 carats, 14 cts,18 cts and 24cts (pure gold). To gild our objects and give our customers the highest quality, we use only 24 carats gold by a galvanizing process.
The Crystal We use Crystal mostly for lamps or vases in different shapes and colors. It is hand cut by specialized craftsmen.


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Kawana Waters Toastmasters Club
Toastmasters is a respected not-for- profit worldwide group. In Australia alone there are 500 clubs.
Want a powerful boost to your confidence & self-esteem? Need help giving presentations to a group or just having conversations with people in general? Is English your second language? Are you looking for a great brain workout among friends? Whether you are a professional, worker, student, stay at home or retiree, Kawana Waters Toastmasters Club is the most supportive, enjoyable and affordable way of gaining great communication and leadership skills, and you'll love the encouraging applause! You are invited to come along for free for three meetings, before becoming a member. We love welcoming visitors and you'll find out what Toastmasters can do for you. Our meetings are run in a fairly structured way so that everyone has the opportunity to shine, and there is always a lot of laughter. We pride ourselves on being a well-run, warm and friendly club. We hope to see you soon.
Fees / Subscriptions: Yes - 50 one-off joining fee plus $100 yearly fee We specifically work with: Anyone Kawana Waters Toastmasters is for anyone, in all walks of life and in any age group above 18 years.


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Game Review: Assassins Creed Rogue (Xbox 360)
Assassins Creed Rogue takes the gameplay of Black Flag and introduces a couple of new touches to help keep things fresh.
Assassins Creed Rogue takes the gameplay of Black Flag and introduces a couple of new touches to help keep things fresh.
Murdered: Soul Suspect is an adventure stealth video game developed by Airtight Games and published in 2014 by Square Enix.
Phantom Breaker: Battle Grounds is a beat 'em up developed by 5pb. Division 2 and published by 5pb. in 2013. It is a spin-off of the fighting game Phantom Breaker.
Have you heard of Dark Souls? Of course you have but what have you heard? I reckon it goes something like this…Dark Souls is one of the hardest games ever made.
Omerta: City of Gangsters has a really solid idea on paper…a sim that puts you in control as you fight to make your name in the Mafia.
Tropico 4 is city building simulation that puts you in the role of El Presidente. The games campaign takes place over 20 missions & is divided into 3 acts.
Five years have passed since the events of Borderlands, when the four Vault Hunters, Roland, Mordecai, Lilith, and Brick were guided by a mysterious entity
Escape Dead Island was a clear change in direction for the Dead Island series & one that had a few people excited especially after its trippy trailer. Sadly the end result is a mess of crappy visuals, poor story, even poorer voice acting & horrible combat.


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Skip to the final section for a quick, spoiler-free rating.
Go Princess Go (Chinese title: 太子妃升职记) made news back in early 2016 after a ban and subsequent censorship by the Chinese government. Reportedly, over a third of the drama got cut before the powers that be allowed it back into the world. After reading about why it fell under so much scrutiny, I was naturally intrigued.
The drama follows a twenty-first century playboy, Zhang Peng, who accidentally transmigrates back in time as the crown princess consort of an unspecified dynasty, named Zhang Pengpeng. Trapped in a woman's body, he spends his days flirting with his husband's harem and in denial of his new biological sex, all the while navigating the rocky terrains of his marriage. As he slowly embraces his new gender, he comes to know his husband, and eventually falls in love with him.
With the Chinese media as devoid of LGBTQ+ shows as it was, how could I resist?
A Campy and Delightful Experience
Go Princess Go was supposedly shot in 70 days on a budget of 20 million yuan (3 million USD), which is not a lot of money for a drama series. The quality of costumes and set designs were abysmal as a result.
I cannot stress how awful this drama looks visually: The dresses female characters wear look suspiciously Greco-Roman. The shade of gold they painted the few furniture in the drama will make you want to claw your eyes out. Windows and doors are missing in favor of sheer curtains, which are kept moving by inexplicable wind at all times. The imperial decree scrolls are purple.
I counted no less than three instances of product placements for a Chinese brand of sildenafil (Viagra), which was apparently the only sponsorship they got for the drama.
What makes Go Princess Go great is how the production team leaned into the budgetary shortcomings in a Monty Python and the Holy Grail kind of way, making what should've been flaws look intentional. What came out of these limitations is a hilarious, campy work of art full of modern-day pop culture references and memes. I only wish I was more fluent in Chinese and China's pop culture to understand some of the jokes and puns I likely missed.
Go Princess Go on a Story-Level
A part of me wonders how much of the parodying of period dramas was by necessity, and how much of it was deliberate. As much as Go Princess Go pokes fun at various genres and tropes, it also delivers a solid story and took itself seriously on that front. None of the dramatic aspects are played for jokes. All of the characters' personal developments, and the emotion states that drive their choices and actions, are as grounded and real as they get.
Watching this drama oscillate between the two extremes, especially later on, is jarring. But it works. And because it's actually a serious story, I'm treating it as such.
I get why Zhang Peng would collude with the Ninth Prince in the first place. He's suddenly married to a(nother) man who found the woman who previously inhabited his new body despicable, and tried to have her killed. But a drawback of having a story so loaded with jokes and gag scenes is that a lot of the conflict tension gets lost. In the later episodes (right after they had sex a second time, I believe?) I had to keep reminding myself why our main character started this conspiracy plot in the first place and why it still makes sense for him to be committed to it—the whimsicality was not helping.
The drama does a great job bringing it back to seriousness towards the end, though, with the now female-identifying Zhang Pengpeng articulating her lack of trust in Qi Sheng and how that puts a damper on their relationship.
I feel so bad for the Ninth Prince, by the way. Zhang Peng plays with his feelings so hard, and Qi Sheng screws him up so much, it's upsetting.
Go Princess Go Ending Explained
The endings? A confusing mess as, apparently, there are three of them.
The first one is the official ending as seen in episode 35. Qi Sheng gives up the throne to their six(?) year old son to travel the world with Pengpeng—first of all, what the hell? Why would you leave a child in charge? What kind of shit parents are these people?!—and live in carefree, domestic bliss. One day, a group of assassins, supposedly led by Yang Yan avenging the Ninth Prince, descend on their private paradise and slaughter them both. In the modern world, Zhang Peng is seen in a coma as he relives moments of his life as Zhang Pengpeng, in both her shoes and Qi Sheng's. Sort of implying that he's both of them and the whole drama was a deep, intense dream.
The same thing happens in the second ending, officially episode 36, except there are no assassins. Instead, the dream world/life of domestic bliss ends on a happy note. Zhang Peng wakes up from his coma in a hospital in a panic, looking for Qi Sheng. He finds a Qi Sheng doppelganger who is a doctor (maybe his doctor?). Their eyes meet and the drama ends.
I could only find the third ending with Vietnamese subtitles for some reason. In it, they're killed by assassins. Zhang Pengpeng wakes up in a dream-like place under a cherry blossom tree. She sees Qi Zheng and reunites with him. Just as they're about to kiss, the fourth wall gets broken by the director yelling at them for kissing too slow and taking up too much film time. The two actors get kicked off set for a commercial shoot, but later kiss out of character on a busy street in front of their fellow actors.
I like the second ending the best. Would love to see a sequel of Zhang Peng dealing with his newfound sense of self, and a possible relationship between him and the Qi Sheng lookalike.
A Word on the Gender Identity Stuff
I don't know how to feel about this drama's portrayal of gender identity.
On one hand, there are a number of on-point characteristics of gender dysphoria throughout; Zhang Peng correcting everyone on gendered languages, him getting angry when they refer to him otherwise, his initial aversion to pregnancy, his instances of dissociation, etc.
But then the drama did a one-eighty on all the good work they layered and had Zhang Peng accepting and embracing the body's biological sex towards the end, which left me stumped.
Maybe I'm limited by my own queer experiences and western upbringing, but that's… not… how trans people work? It's the body that has to reconcile with the mind, not the other way around. Even for non-cisgender people who don't experience physical dysphoria, whether they're trans and just don't, or are non-binary/genderqueer, their personal sense of identity is still independent of their body. And people's gender identities are certainly not dictated by the gender of the person they fall in love with, which this drama strongly implies to be the case; feeling feminine is not the same thing as "feeling like I should be a woman." There's just a lot to unpack here, even more so given the unconventional and impossible premise.
That being said, I still love that Go Princess Go tackles it with as much fun as it does. And considering China's stance on LGBTQ+ issues (and, weirdly, time travel?), kudos to this drama's ballsiness.
Final Rating and Recommendations
Go Princess Go is an entertaining spectacle that should not be as good as it is. I recommend it to anyone who wants to watch something on zero brain power. If you can look past the atrocious quality of the costumes and set designs, and don't mind not taking the drama too seriously, you're going to have a great time. Know that for all the jokes and gags in this drama, there is a good story waiting for you once you're invested. The twists and turns of the plot, the schemes and betrayals between characters are amazing, considering the time and budget constraints the production team faced.
Otherwise, there's a Korean adaptation made with a much bigger budget and better quality writing waiting for you, which is what I'm watching next. I have high hopes, Mr. Queen, don't disappoint me! (Update: Spoiler, it didn't!)
My Rating: 7/10