text:
We retrospectively
reviewed the outcome of docetaxel, EMP, and carboplatin (DEC) as second-line
chemotherapy in castration-resistant prostate cancer (CRPC) patients previously
treated with docetaxel-prednisolone (DP). Nineteen patients pretreated with DP received
a DEC regimen which consisted of a 28-day cycle of docetaxel [60 mg/m2 intravenously (IV) on day 1)], carboplatin (IV to an area under the curve of 5
on day 1), and EMP (560 mg orally daily). The DEC therapy was continued
intermittently after two consecutive courses. End points were DEC effect on prostate-specific
antigen (PSA), radiographic response, progression-free survival (PFS), and
overall survival (OS). All patients received DP before DEC administration with
a median of 6 cycles (range, 1 - 12). Mean follow-up duration was 19.0 months
after starting DEC therapy; median total number of the therapy cycles was 2
(range, 1 - 11). Thirteen patients (68.4%) showed a PSA decrease; 6 (31.6%)
showed a decrease in the PSA level of ≥50%, including 4 with no PSA response to
DP. Grade 3/4 neutropenia and febrile neutropenia were observed in 13 (68.4%)
and 2 (10.5%) patients, respectively. The median PFS following DEC was 3.7
months. The median OS was 18.0 months. In univariate analyses, patients with
≤12 months from CRPC to DEC had shorter PFS and OS, whereas PSA response to DP
was not associated with PFS or OS in CRPC patients treated with DEC after DP. In
conclusion, DEC retains some clinical benefits for CRPC patients pretreated
with DP, even in patients without any response to DP. Therefore, they may be an
effective and feasible treatment option for CRPC patients after first-line
docetaxel therapy, particularly for those deemed unfit for novel endocrine and
chemotherapeutic drugs.
Chemotherapy, Carboplatin, Docetaxel, Estramustine Phosphate, Prostate Cancer
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Received 30 May 2016; accepted 27 June 2016; published 30 June 2016
1. Introduction
Prostate cancer is the second leading cause of cancer mortality among men worldwide [1] . While it initially responds to androgen deprivation therapy, it eventually becomes castration-resistant in most patients. Docetaxel has been a standard first-line treatment in patients with castration-resistant prostate cancer (CRPC) for almost a decade; however, novel drugs have now become available, including enzalutamide, abiraterone acetate, and cabazitaxel, which can be used in pre- and/or post-docetaxel settings [2] . Several studies have indicated that the clinical cross-resistances between docetaxel and novel androgen receptor (AR) signaling-targeted drugs existed [3] [4] . Furthermore, a novel chemotherapy agent cabazitaxel, which has been suggested to have a little cross resistance to new AR signaling-targeted agents, is reported to be accompanied by severe toxicities in a substantial number of patients, particularly in Asian patients [5] [6] .
Platinum compounds, which have historically been believed to have only modest activity for prostate cancer in monotherapy [7] , have also been shown to be effective when combined with taxanes and estramustine phosphate (EMP) in phase I - II studies [8] - [11] . In its pooled analysis, the response of prostate-specific antigen (PSA) levels and 12-month survival estimate were reported to be 69% and 79%, respectively [12] . We previously demonstrated that intermittent chemotherapy with docetaxel, EMP, and carboplatin (DEC) was a feasible option for CRPC based on the outcome with a decrease in the PSA level by ≥30% with 65.7% of patients and the median overall survival (OS) of 17.8 months [13] . These studies only assessed the outcomes for taxanes, EMP, and carboplatin (TEC) in first-line settings; therefore, the efficacy and feasibility of TEC as second-line chemotherapy in patients with CRPC who previously received docetaxel remain unknown.
In this study, we retrospectively assessed the outcome of combination therapy with DEC as second-line chemotherapy in patients with CRPC who were previously treated with docetaxel-prednisolone (DP) therapy.
2. Patients and Methods
2.1. Patients
We included all patients with confirmed CRPC who were previously treated with DP therapy. The definition of CRPC was histologically confirmed adenocarcinoma of the prostate with PSA or radiographic progression despite surgical or medical castration, with a serum testosterone level of 50 ng/dL or less. All patients were pretreated with a 28-day cycle of DP therapy, which consisted of docetaxel (70 mg/m2 on day 1) and oral prednisolone (10 mg/day) in more than 1 cycle. The treatment of DP therapy was applied as an intermittent protocol using our original regimen. Briefly, three consecutive administrations of docetaxel in a 28-day cycle were defined as one course of the DP therapy. If the patient achieved PSA or clinical response during a course of therapy, a treatment holiday was taken until the patient's PSA level returned to the baseline. The DP therapy was intermittently continued until treatment failure (as defined above), intolerable drug toxicities occurred, or the patient refused further treatment.
2.2. Procedure and Treatment
This study and the DEC protocol were approved by the institutional review board of Akita University School of Medicine. The patients were treated with a DEC regimen that consisted of a 28-day cycle of docetaxel [60 mg/m2 intravenously (IV) on day 1)], carboplatin (IV to an area under the curve of 5 on day 1), and EMP (560 mg orally daily). Pre-medication was with dexamethasone (8 mg IV), which was 30 min before each docetaxel infusion. The detailed regimen has been previously described [13] . Briefly, two consecutive DEC therapies were performed, followed by the assessment of efficacy and toxicity. Before further therapy with the DEC therapy, a chemotherapy holiday was taken until the PSA levels increased to above baseline. Dose-reduction was allowed for elderly patients, those with a low performance status, and those with a history of severe adverse events. A luteinizing hormone-releasing hormone agonist was continued throughout the study. Treatment was stopped for any of the following reasons: progression of disease, severe adverse events, patient's refusal of further treatment, or at the physician's discretion. The administration of zoledronic acid or denosumab was allowed for patients with bone metastasis.
2.3. Outcome and Statistical Analysis
The study end points were the PSA response rate, radiographic response, progression free survival (PFS), and OS. PSA and radiographic progression were defined according to the criteria of the Prostate Cancer Clinical Trials Working Group 2 [14] . We measured PSA levels at least every 3 months after starting chemotherapy. A post-therapy PSA response was calculated using the maximum degree of change from baseline within 3 months. PSA response and PFS was defined as a decrease in the PSA level of ≥50% and the period from the initiation of DEC therapy to PSA progression and/or radiographic progression, respectively. Toxicity was graded according to the National Cancer Institute Common Toxicity Criteria version 4.0 (NCI-CTC v4.0).
Regarding statistical analyses, continuous variables are expressed as median values. OS and PFS were estimated using the Kaplan?Meier method. To identify risk factors for PFS and OS, univariate analysis was conducted using the following variables: patient age, Eastern Cooperative Oncology Group performance status, baseline PSA, baseline alkaline phosphatase, baseline lactate dehydrogenase, baseline hemoglobin, PSA response to the previous DP therapy, total cycles of previous DP therapy, duration from CRPC to the DEC therapy, visceral metastasis presence, and Gleason score at biopsy. All reported p values were two-sided, with statistical significance considered at p < 0.05.
3. Results
3.1. Patient Characteristics
In total, 19 patients received DEC therapy after first-line chemotherapy with DP from May 2010 to March 2014. Table 1 summarizes the baseline patient characteristics before DEC therapy. The median age was 65 years (range, 51 - 79 years), and most patients (89.5%) had a performance status of 0 or 1. In addition, 73.7% of the patients had a Gleason score of ≥8, and the median baseline PSA level was 67.0 ng/mL (range, 9.1 - 1102 ng/mL). A total of 18 (94.7%) patients had bone metastasis, whereas visceral metastasis was observed in 5 (26.3%) patients. The median time from diagnosis to docetaxel administration was 27.0 months (range, 3.0 - 1313 months), whereas the median time from docetaxel administration to DEC therapy was 13 months (range, 4.0 - 29 months). The median time from CRPC to DEC was 17 months (range, 5.0 - 57 months). All patients received a median of 6 cycles (range, 1 - 12) of DP therapy before receiving DEC therapy. In addition, 12 (63.2%), 3 (15.8%), and 16 (84.2%) patients had previously received flutamide, chlormadinone acetate, and EMP, respectively.
3.2. Treatment Outcome
The mean follow-up period was 19.0 months, and patients received a median of 2 (range, 1 - 11) cycles of DEC therapy. The maximum response to DEC therapy is shown in Figure 1 and Table 2. Of the 19 patients, 13 (68.4%) had a PSA decrease, with 6 (31.6%) having a decrease of ≥50%. All patients were withdrawn from DEC therapy during the study period because of disease progression, except for one patient who experienced grade 3 general fatigue as a side effect. The median PFS was 3.7 months (range, 0.5 - 20.4 months). In 10 patients (52.6%) with evaluable extraosseous metastases, 1 patient (10%) achieved partial response and 6 patients (60%) achieved stable disease according to the Response Evaluation Criteria in Solid Tumors. Ten patients (52.6%) survived to the end of the study period, and the median OS was 18.0 months (Figure 2). The 1- and 2-year survival rates were 55.2% and 46%, respectively.
Table 1. Patient characteristics.
ECOG = Eastern Cooperative Oncology Group, DEC = docetazel, estramustine phosphate, and carboplatin, DP = docetaxel and prednisolone, PSA = prostate specific antigen, EMP = estramustine phosphate.
Table 2. Clinical outcomes.
PSA = prostate specific antigen, PR = partial response, SD = stable disease, pts = patients.
Figure 1. Waterfall graph of maximal changes in prostate-specific antigen levels after the administration of docetaxel, estramustine phosphate, and carboplatin in castration-resistant prostate cancer after first-line docetaxel and prednisolone therapy.
Figure 2. Kaplan-Meier curve for overall survival in patients with castration-resistant prostate cancer who were treated with docetaxel, estramustine phosphate, and carboplatin after docetaxel and prednisolone therapy.
3.3. Toxicity
A detailed toxicity profile during the study period is shown in Table 3. The most frequent grade 3 or 4 adverse events were neutropenia (68.4%), anemia (21.1%), thrombocytopenia (10.5%), and febrile neutropenia (10.5%). Non-hematologic adverse event exceeding grade 3 was observed in 2 patients (10.5%). There were no deaths due to treatment-related adverse event.
3.4. Pretreatment Variables for Clinical Outcome
We assessed the relationship between PSA response to DP therapy and treatment outcome from DEC therapy. Among the 13 patients without a PSA response to DP therapy, 4 (30.8%) achieved a PSA response to DEC therapy. In addition, among the 6 patients who had a PSA response to DEC therapy, 4 (66.7%) had no prior PSA response to DP therapy. On univariate analyses (Table 4), a duration from CRPC to DEC of ≤12 months was a significant risk factor of both PFS [hazard ratio (HR) = 3.055, *p = 0.047] and OS (HR = 5.790, *p = 0.033). Furthermore, the presence of visceral metastasis was significantly associated with a poor OS (HR = 6.139, *p = 0.027). The PSA response to DP therapy had no statistically significant impact on PFS or OS in patients with CRPC receiving DEC therapy after DP therapy.
Table 3. Overall toxicities according to grade (CTCAE v4.0).
Table 4. Univariate analysis for progression free survival and overall survival in patients with castration-resistant prostate cancer treated with docetaxel, estramustine phosphate and carboplatine therapy after docetaxel and prednisolone therapy.
4. Discussions
Recently the outcomes have been reported for several combination chemotherapies and novel drugs as second- line treatment after docetaxel in CRPC [6] [15] - [20] (Table 5). Based on the large randomized trials, two novel drugs targeting AR signaling and chemotherapy with cabazitaxel achieved a PSA decrease of ≥50% in 29.4% - 54% of patients and a median OS of 15.1 - 18.4 months. Several combination chemotherapeutic regimens have also been reported to achieve a PSA decrease of ≥50% in 18% - 60% of patients and a median OS of 12.4 - 19
Table 5. Summary of the outcome of second-line therapy in patients with castration-resistant prostate cancer after docetaxel therapy.
EMP: estramustine phosphate, PFS: progression free survival, OS: overall survival, N/A: not assessed.
months [6] [15] - [20] . It is not valid to directly compare the outcomes between the previous reports and the current study because of the substantial differences in patient backgrounds and treatment regimens; however, we showed that DEC therapy is equivalent to other second-line treatments administered to patients after first-line docetaxel-based chemotherapy. Although the survival rate in some groups of the pateints in the current study seems to be worse than that in the previous study, most of the patients in the current study were previously heavily treated with second or thrid-line hormonal therapy (flutamide, 63.2%; chlormadinone acetate, 15.8%) and EMP (84.2%) in addition to docetaxel administration. Therefore, the outcomes in patients treated with our DEC therapy with a PSA decrease of ≥50% in 31.6% of patients and a median OS of 18.0 months could be feasible enough in this setting.
In a study evaluating the efficacy of second-line docetaxel-based chemotherapy, Nakabayashi et al. showed that docetaxel plus carboplatin had a modest effect, with PSA levels decreasing up to ≥50% in 20% of patients and a median OS of 14.9 months [21] . In another study of combination chemotherapy with TEC as second-line therapy, Sella et al. demonstrated the efficacy of combination paclitaxel, carboplatin, and EMP in 15 patients previously treated with docetaxel [18] . In the study, the PSA level decreased to ≥50% in 60% of patients, and a partial response was observed in 40%. Based on the results of the second-line taxane-based combination chemotherapies, including our result, the studies that included EMP and carboplatin in combination with a taxane appeared to have relatively better outcomes, potentially exploiting specific advantages of each drug for CRPC [18] . In vitro study has also shown the synergistic effect among these three drugs [22] . However, in the study using paclitaxel, one patient died due to brain hemorrhage following prolonged thrombocytopenia and four patients withdrawn from therapy due to toxicity [18] . Further study is warranted to determine which taxane is the best candidate partner for EMP and carboplatin to maximize the therapeutic effect and avoid severe adverse events.
Cabazitaxel is a promising second-line chemotherapeutic agent for patients with CRPC who fail to respond to first-line docetaxel chemotherapy. However, the problem with cabazitaxel treatment is the high incidence of severe side effects such as neutropenia and febrile neutropenia [5] [6] . Recent studies have shown that the rate of febrile neutropenia was extremely high in Asian patients (31% - 54.5%) [5] [6] . In our study, the incidence of febrile neutropenia was 10.5%, equivalent to the incidence in an international landmark trial of cabazitaxel (8%) [15] but lower than the rate in the phase I trial of cabazitaxel in Japanese patients (54.5%) [6] . Nevertheless, DEC therapy achieved a decrease in the PSA level of ≥50% in 31.6% of patients, which was not inferior to the outcomes of that phase I study (29.3%) [6] . These results indicate that patients who are expected to be unfit for cabazitaxel, particularly Asian patients, will be good candidates for the DEC therapy.
Another important issue in the treatment of patients with CRPC is to identify the best candidate for TEC therapy. Regan et al. conducted a meta-analysis that included seven trials using TEC and revealed that the absence of extra-skeletal metastases, a higher hemoglobin, and lower performance status, lactate dehydrogenase, alkaline phosphatase, and PSA at enrollment were associated with longer survival [12] . Our previous study also showed that serum lactate dehydrogenase was an independent prognostic factor for OS in patients with CRPC who received DEC therapy [13] . As these trials examined the prognostic factors for TEC therapies in the first- line setting, these needed to be carefully applied to second-line settings, which we did in the current study. In second-line therapy, we showed that short duration from CRPC to DEC and the presence of visceral metastasis were significant risk factors of OS. Because these results imply that patients with these risk factors cannot achieve good response to current therapeutic options [23] [24] , novel therapeutic approaches need to be developed for CRPC with these aggressive phenotypes.
We also focused on the impact of the PSA response to previous DP therapy on the PSA response to current DEC therapy. Our study revealed that the PSA response to previous DP therapy had no impact on any clinical outcomes, including the PSA response, PFS, and OS, in patients treated with the second-line DEC therapy. Therefore, it is possible that DEC therapy could be a feasible second-line chemotherapy option, even in patients with no PSA response to first-line docetaxel-based chemotherapy.
This study has some limitations, including a retrospective design, short follow-up duration, and small sample size. A Randomized trial should be needed to compare our results with those in the patients treated by classical methods. In addition, DP and DEC therapies were administered intermittently, according to our original protocol [13] . Therefore, the effect of continuous administration of DEC therapy, which is a more common protocol of taxane administration, remains unclear. Furthermore, none of the patients had received therapy from the new classes of drugs such as abiraterone acetate, enzalutamide, and cabazitaxel. The advantage of implementing DEC therapy before or after these novel drugs therefore also remains unclear and should be resolved in a future study.
5. Conclusion
We show that DEC therapy is feasible and beneficial in patients with CRPC after DP therapy. It produced relatively modest side effect and comparable response rates compared with previous studies evaluating the effects of second-line chemotherapy options. Thus, DEC may be an effective and feasible treatment option for patients with CRPC after the failure of first-line DP, particularly those deemed unfit for novel endocrine and chemotherapeutic drugs.
We thank Yoko Mitobe, Yuka Izumida, Yukiko Sugiyama, and Saeko Nakamura for technical assistance.
*Corresponding author.
Conflicts of Interest
The authors declare no conflicts of interest.
Copyright © 2023 by authors and Scientific Research Publishing Inc.
This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.


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History Lesson
At Home [Interiors]
Islands are treasures in themselves. But Jamestown has a lion's share of remarkable architecture, too, that in light of ever-encroaching development, residents are wisely stepping up efforts to conserve. Charles L. Bevins's work is a perfect example. "Bevins was Jamestown's finest shingle-style architect," says Campbell-King. Often overshadowed by his more flamboyant Newport contemporaries McKim, Meade and White, Bevins designed several other buildings on Jamestown as well. Surprisingly well-suited for today's relaxed lifestyle, Campbell-King's residence was commissioned by Rear Admiral Logan, a member of the Union Navy under President Abraham Lincoln, as a wedding present for his daughter in 1888. Light-filled and airy, the comfortable rooms welcome a steady stream of family and friends year round.
Bedtime Story
William Morris wallpaper complements Bevins's charming asymmetric fireplace surround in the guest suite. The dragon andirons on the mantel are also attributed to Bevins. The painting is by Campbell-King. The brass bed is a family piece.
Campbell-King's entry packs a wealth of details. According to the architect, "the small paned windows are typical shingle-style and Bevins. The Dutch door is a summer house signature. You leave the top open for breezes." Campbell-King moved in an Asian table (the antique box on top holds a cache of favorite photos for easy viewing) and mirror as a subtle nod to the woodwork's Japanese influence. Long stemmed dried allium pods,"reminiscent of fireworks," says Campbell-King, enhance a tag-sale vase.
Food Network
Rather than a glitzy galley that would have upstaged the rest of the house, at the heart is a kitchen in which Bevins would feel at ease. A crisp white palette, pale Carrera marble counters and a decoratively painted pine floor, painted by Campbell-King to mimic the marble, are the backbone of a hub that's welcoming and efficient. Beadboard is a touch of the antique; quality stainless appliances look to the future. And thanks to a bounty of straightforward cabinetry (note the classic bin pulls), clutter is a non-issue. The existing windows, installed by previous owners, might have been a personality drain. Instead, the architect cleverly added shelves. The result? An instant mood change and more storage. A simple drop-leaf style table serves for everyday meals and intimate dinners with guests, while the curvaceous ceiling fixture is, Campbell-King says, "a bit of whimsy that gets the light where it needs to go."
High Drama
Campbell-King's art talent is evident everywhere from her luminous paintings (the large composition to the right of the porch door above is "Zeek's Creek") to the zany floor cloth in the entry hall. The era-appropriate cloth, she explains, was done with latex house paint in colors inspired by the crewel curtains in the sitting area and more formal dining area (above). The woodwork was originally dark stained wood, but all of it, even the sunbursts, paneling and mantels were doused with a coat of green paint. Campbell-King opted for Benjamin Moore Dove White throughout to bring Bevins's flourishes back to life. "A calm palette, paired with lots of texture for interest, seemed the right solution," says the architect. The round table, which also stands in as a station for an ever-growing collection of books, is really a humble, metal-legged caterer's table. A glass top and floor-length cloth successfully elevate its persona. The handsome chairs, once seats in the Senate, were purchased at a Washington, D.C., auction by Campbell-King's mother and reworked with cane seats. To the opposite side of the wide entry are the stairs framed by a picturesque lattice-like railing (right). "Bevins and the shingle-style love to have dramatically lit stair halls," Campbell-King tells us. "This was just a small cottage, but it still got the larger-than-usual stair treatment."
Outward Bound
Campbell-King swapped lackluster double-hung windows for tilt-out models and installed skylights to brighten the sun-porch (left). New shingle-clad walls link the space to the home's exterior. Adjacent to the living room, the porch extends living space, while affording water views. Easygoing wicker furnishings with traditional striped cushions keep the mood summery no matter what the weather.
Garden Party
Once an undefined meadow rolling to the street, Campbell-King's property is now, tons of fill and hours of toil later, a well-orchestrated, tiered garden. The architect maintained an existing privet hedge, but rerouted the entry path (right), a combination of bluestone and old brick found buried on the grounds, to be more accessible from the parking area. According to Campbell-King, power-washing and sealant assure the shingles remain a warm brown hue rather than weathering to grey in the salt air. "The entry deck and detail are all original," she says. "The overhang swoops out to protect visitors from the rain." The gate is a copy of one designed by Thomas Jefferson, one of Campbell-King's favorite American architects, for Monticello. To maximize the appealing setting, she also added an angled deck protected by a wisteria-draped pergola and roll-away awning. The catchy wrought iron clock face, from Karen Vaughan in Newport, is a reminder that time goes by, Campbell-King says. A gardener at heart, the owner has a burgeoning plant list that includes a robust Nepeta border, plenty of perennials, David Austin roses, shrubs and trees.

subset: commoncrawl


text:
[Vlog] Introducing Check C Framework: The Power-Packed Tool for Unit Testing of Automotive Software
An automotive software, like any other piece of code is developed as separate modules or software units. Verification of these modules is one of the most crucial tasks, during the product development projects.
During Unit Testing, each software unit/module is tested individually. The efficacy of unit testing depends on the following two factors:
- How accurately the test-cases have been designed?
- How diligently are these test-cases executed?
Check C is a champion in both these aspects. Being a robust unit testing tool for C language, it provides an interface for designing the test cases as per the required coverages.
The Check C Framework also facilitates automatic execution of these test cases and generation of the unit test reports.
Although Check C is not a pure-play testing automation tool, but the developers and test engineers vouch for its efficiency and flexibility in accurate designing of the test-cases and their execution.
In our latest video, we introduce to you the Check C tool, its various features and value-adds.
Check C Framework: Key Take Away from the Video
- What is Check C Framework?
- Step-by-Step Unit Testing Flowchart (using Check C Framework)?
- Unit Testing Methods Supported by Check C
Check C is an indispensable tool for software developers who code in C Language. As automotive embedded software are mostly written in C, this tool serves as a go-to Unit Testing tool for automotive product development teams.
If you are a budding developer or test engineer, this video will be your doorway to the world of unit testing of automotive software.
If you like the video, do show some love by liking and sharing the video. We have more such videos on our channel and tons of them are going to be released soon. So, don't forget to subscribe the channel!


text:
Growth in the UK and Ireland has led Cube Bikes to move into a new office and integrated warehouse – it's fifth location in ten years.
Oneway Bike*/Cube Bike's move to the new premises near Rotterdam, Netherlands, were branded a necessity by the firm following four years of strong expansion.
The new warehouse now features a 30,000 bike capacity, with a separate location for P&A.
CEO Lennard van Winden explained: "Our old office became a little small with our expansion in the last four years, with our staff number growing from six to 21.
"Especially the growth in our UK and Irish markets demanded wider and deeper stock positions. In our new warehouse we are able to carry stock of 30,000 bikes plus a separate location for Cube parts and accessories."
The move took place last weekend (January 22nd and 23rd) with minimal disruption, the firm said.
Sales Manager Bart van den Biggelaar added: "The new pride of our company is our showroom for bikes, parts and accessories – complete with training facilities for our 'Cube Academy', which will be launched this spring.
"We also plan to make this service available for our UK and Irish customers. Later in the season this will also be the location for our new product launches."
Oneway Bike Industry BV
Molenbaan 3
The Netherlands
Email: email@example.com
Website: www.cube.eu
Webshop: www.cubeb2b.com
New telephone for UK and Irish customers: +31 10 340 3502
*Oneway Bike is the exclusive distributor for Cube in the Netherlands. In 2006 Oneway founded UK subsidiary Cube UK Ltd, responsible for sales and distribution in the United Kingdom and Ireland.


text:
What would be your ideal setting for Christmas? A cosy country cottage far away from everything, a homely house in a village where everyone knows each other or an awesome apartment in a big city? Are you a country or city girl/boy?
Both have their advantages, of course. I believe that Christmas in a city has its own charm, and here are some vintage cards that (hopefully) convey that feeling. I have sneaked in a couple of cards from a previous post – I think they're worth a second viewing.
Here's a card that combines country and city – I love it because it has everything I love – a deer, snow, starry night and skyscrapers!
Continuing the theme and nicely finishing it off, here is a purely instrumental gem by Marvin Gaye – probably not what you'd expect from him – I think it's quite evocative of the feel of a city in winter.


text:
Space exploration—our greatest adventure—is having a big impact on our lives. It's helping us to discover a universe of unimaginable scale and beauty, and it's reaching down into our world and influencing the way we live.
To Space & Back takes audiences on an incredible journey from the far reaches of our known universe to our own planet. It is an extraordinary story of human ingenuity and incredible engineering, describing how the technology that transports us through space is paving the way for the devices and apps we use every day. What's happening above is coming back down to Earth!
Discover how we've been changed by space exploration, and what we owe to curiosity and the spirit of discovery.
We would like to thank our new system vendor Sky Skan, for offering us the ability to show this program during this uncertain time.
Produced by Sky-Skan in association with The Franklin Institute
Narrated by James May
Running time: 25 minutes
Suitable for family and schools audiences
Educator's Guide


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The Provincial Court of BC has been holding court in Bella Bella, Klemtu, and Bella Coola on BC's Central Coast for many years.
Located on the mainland, Bella Coola is the home of the Nuxalk First Nation. The Campbell Island community of Bella Bella is home to the Heiltsuk First Nation. The Kitasoo First Nation's home is Klemtu, north of Bella Bella on Swindle Island. They are three of the communities the Provincial Court serves with a circuit court – a judge and court team who visit the community at regular intervals and set up a courtroom in an available building to conduct court proceedings. Judges are assigned to a circuit court for several years so they can learn about the communities they visit and provide consistent decision making, applying restorative justice principles and drafting court orders that are sensitive to local circumstances.
When consulted during the coronavirus pandemic, remote communities asked that the circuit court members not to attend in person in order to avoid the risk of introducing COVID-19. The Court has therefore been dealing with cases from those communities by telephone and when available (as in Bella Bella and Bella Coola), by video using an existing hard-wired system.
On May 22, 2020, technology moved the Court a step further when Judge Brent Hoy conducted court in Bella Coola using Microsoft Teams. The judge and lawyers dealt with criminal and family matters remotely in a virtual courtroom on this platform.
Judge Hoy said, "Access to justice has just been dramatically enhanced with the innovative use of new technology." One law firm that participated tweeted, "Just finished participating in the first @BCProvCourt live on record, court clerked proceeding using @MicrosoftTeams. Move over sliced bread: your day has come and gone. Great experience."
In simpler pre-pandemic times last summer Judge Hoy decided that a Bella Bella sentencing hearing in a case with significant community interest required a "circle sentencing" – a type of hearing that encourages community input and is in keeping with Heiltsuk Nation traditions. With the agreement of everyone involved, arrangements were made for the hearing to proceed in this manner in the community gymnasium on July 16, 2019. It was an elaborate, tradition-filled event that included drummers, songs and ceremonial robes.
Chairs in the sentencing circle
At the end of the sentencing, the community held a luncheon to which everyone was invited. Those attending included Marilyn Slett, Chief Councillor of the Heiltsuk Nation, and other elected representatives, Elders, hereditary chiefs and community members. After the meal, Pauline Waterfall, an Elder and recipient of the Order of BC, officiated at a ceremony in which several community members were honoured by being blanketed – presented with a ceremonial blanket in recognition of an accomplishment or contribution.
In describing the event, Judge Hoy says, "What occurred next was completely unexpected as she asked me to come forward! I was caught completely off guard."
Blanketing Judge Hoy, Ms. Waterfall welcomed him to the territory of the Heiltsuk Nation and thanked him for giving its members the opportunity to express themselves. She said the community appreciated the kindness and respect he afforded them.
Judge Hoy in turn thanked everyone for contributing to their community and commented on the importance of ensuring all voices are heard. He reports, "Personally, it was extremely gratifying to have had such a positive impact and to receive acknowledgement for our role as judges in this community."
One of the strengths of the community in Bella Bella is the Heiltsuk Nation's successful Restorative Justice Program. At the ceremony, Mary Brown, the Program Director, was honoured as an indispensable part of the community's success in reducing recidivism.
For more about the Bella Bella, Bella Coola and Klemtu circuit court, see:
Bella Coola Circuit Court gets warm community welcome
Circuit Courts: serving remote communities by plane and boat


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Carburetor for CMD65 Backpack Sprayer (1E48FP-E.4)
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|Atomistry » Uranium » Physical Properties
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Physical Properties of Uranium
Pure uranium is a lustrous white metal. When prepared by electrolysis of uranous chloride it is deposited as small glistening crystals; 7 by reduction of the oxide it is usually obtained as a brown or black powder. The metal is malleable, but less so than thorium; it is very ductile and is capable of taking a high polish. It is not hard enough to scratch glass. Its density at 13° C. is 18.685. The metal, when free from iron, is slightly paramagnetic, the susceptibility being +0.9×10-6.
The position of the metal in the electromotive series is not conclusively determined. The electrical potential of uranium in contact with aqueous electrolyte has been measured by Muthmann and Fraunberger, who showed that the pure metal, in contact with a normal solution of potassium chloride, in the element
assumed a potential Hh = -0.46. The metal showed no tendency to become passive, nor does it in the usual passivating anodic solutions, though the latter may be in considerable concentration and a high current density applied. Using an electrode of platinum on which finely powdered uranium was pasted by means of gelatin, Pierle obtained the following value for the metal in contact with an aqueous solution of uranyl nitrate:
U(91.49 per cent.)/UO2(NO3)2 = -0.093 volt.
By placing the metal in contact with an alcoholic solution of uranium hexachloride, Fischer and Rideal obtained values which placed the potential of uranium between those of copper and hydrogen. This, however, is not in agreement with the above results.
The specific heat and atomic heat of the element have been determined as follows:
Uranium melts at a white heat, but the exact temperature has not been determined; Guertler and Pirani found it to be about 1850° C., which is in agreement with a statement by Moissan that uranium is more difficult to melt than platinum. Rideal melted in a vacuum a specimen of uranium containing 0.4 per cent, carbon; fusion occurred between 1300° and 1400° C. The boiling-point has not been determined, but Moissan found that the metal could be distilled more readily than iron in the electric furnace.
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text: Each year, the editors of Time magazine choose the person of the year – the one who has most influenced the news and the world over the past year. But this year, their cover page reading "Donald Trump: President of the Divided States of America" caused a major stir on social networks. And all because of one letter making Trump looks devilish.


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Volvo has a well-established reputation of building the safest passenger vehicles in the industry but the carmaker believes it can improve on its own standards by reaching the ultimate goal of avoiding car accidents all together and reducing the road death toll to zero. Volvo has now set itself the ambitious target of zero injuries or deaths in its vehicles by 2020.
A spokesman for Volvo, who spoke with Reuters, revealed the carmaker's desire to eliminate all-crash related injuries and death and eventually the elimination of car accidents altogether. To do so, Volvo plans to create a car that essentially "forms a giant bumper" around its occupants to protect them in the event of an accident.
However, the ideal solution would be to prevent the accident in the first place and thus Volvo is also working on a host of radar-based safety technologies as well.
It the technology proves successful and becomes standard in all cars we could one day see the world-wide annual death toll of 1.2 million people reduced significantly.


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27 September,2023
2020 -Trade Changes| Production
- Global rice production in 2020/21 is forecast at 501.2 million tons (milled basis), up 0.1 million tons from the previous forecast, 1 percent above a year earlier and the highest on record.
- Argentina, Australia, Bolivia, Burma, China, Colombia, Guyana, Honduras, India, Indonesia, Laos, Mexico, Pakistan, Panama, Sub-Saharan Africa, Thailand, and the United States are each expected to produce more rice in 2020/21 than a year earlier.
- India's crop is projected to increase almost 1.6 million tons to a record 120.0 million tons.
- U.S. crop is projected to rise more than 1.3 million tons.
- Thailand's crop is projected to be up nearly 0.95 million tons from the 2019/20 sharply-reduced, drought-impacted crop.
- Indonesia's production is projected to rise by 0.9 million tons.
- Australia's 2020/21 production forecast of 0.61 million tons is up almost 0.57 million from the 2019/20 drought-reduced harvest, a result of a substantial area recovery.
- Pakistan's 2020/21 production forecast of a record 7.6 million tons is up 0.4 million tons from last year, a result of a higher yield.
- China's forecast production of 147.0 million tons is up just 0.3 million from a year earlier, a result of a slightly larger harvested area.
- Reduced harvested area is responsible for a projected 0.23-million ton drop in the Philippines rice production in 2020/21.
- Production is projected to decline 0.12 million tons in both Brazil and Paraguay in 2020/21, a result of weaker yields.
- Vietnam's 2020/21 production is projected to drop 0.15 million tons as the area continues to decline.
- In contrast, Afghanistan, Bangladesh, Brazil, Cambodia, Egypt, EU, Iraq, South Korea, Madagascar, Paraguay, the Philippines, Sri Lanka, Taiwan, Venezuela, and Vietnam are projected to harvest smaller crops in 2020/21.
Date: 14-Dec-2020
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Total commercial chapter 11 filings in July 2020 increased 52 percent from the previous year, according to data provided by Epiq. Commercial chapter 11 filings totaled 643 in July 2020, expanding from the July 2019 total of 423. Conversely, total commercial filings decreased 17 percent in July 2020, as the 2,768 filings were down from the 3,314 commercial filings registered in July 2019. The 42,861 total bankruptcy filings in July 2020 were down 33 percent from the 64,345 total filings in July 2019. Total consumer filings decreased 34 percent in July 2020, as the 40,093 filings fell from the 61,031 consumer filings registered in July 2019.
"As the government considers renewing or bolstering lifelines to help stabilize the economy, the financial uncertainty due to the COVID-19 pandemic is weighing on families and businesses," said ABI Executive Director Amy Quackenboss. "We anticipate filings increasing in the next few months as more households and companies seek the shelter of bankruptcy amid intensifying financial distress."
Congress is currently considering another economic stimulus package as important aid provisions of the Coronavirus Aid, Relief, and Economic Security Act (CARES Act) have or will shortly expire. The weekly unemployment bonus of $600 established by the CARES Act ended on July 31, and the deadline for businesses to apply for a Paycheck Protection Program loan is August 8.
ABI's COVID-19 Resources website is continually being updated for bankruptcy professionals and the public to access essential information and analysis regarding the financial distress being inflicted by the COVID-19 pandemic. The site features exclusive ABI content on the crisis, weekly filing statistics, recommended member analysis, industry sector news, charts and more. Also, webpage is routinely updated with information, statistics, analysis and events related to the Small Business Reorganization Act of 2019, which went into effect this year to make bankruptcy more accessible, efficient and cheaper for struggling small businesses.
July's commercial chapter 11 filings represented a 6 percent increase from the 609 filings in June 2020. Total commercial filings were up 2 percent over the June 2020 commercial filing total of 2,713. Total bankruptcy filings in July represented a 1 percent increase over the 42,425 total filings recorded the previous month. Total noncommercial filings for July also represented a 1 percent increase from the June 2020 noncommercial filing total of 39,712.
The average nationwide per capita bankruptcy filing rate in July was 1.89 (total filings per 1,000 per population), a slight decrease from the filing rate of 1.92 during the first six months of 2020. Average total filings per day in July 2020 were 1,948, a 33 percent decrease from the 2,925 total daily filings in July 2019. States with the highest per capita filing rates (total filings per 1,000 population) in July 2020 were:
1. Alabama (4.31)
2. Tennessee (3.75)
3. Delaware (3.70)
4. Mississippi (3.35)
5. Georgia (3.12)
19. Arizona (2.08)
ABI has partnered with Epiq in order to provide the most current bankruptcy filing data for analysts, researchers and members of the news media. Epiq is a leading provider of managed technology for the global legal profession. T
ABI is the largest multi-disciplinary, nonpartisan organization dedicated to research and education on matters related to insolvency. ABI was founded in 1982 to provide Congress and the public with unbiased analysis of bankruptcy issues. The ABI membership includes nearly 11,000 attorneys, accountants, bankers, judges, professors, lenders, turnaround specialists and other bankruptcy professionals, providing a forum for the exchange of ideas and information.
Epiq, a global leader in the legal services industry, takes on large-scale, increasingly complex tasks for corporate counsel, law firms, and business professionals with efficiency, clarity, and confidence. Clients rely on Epiq to streamline the administration of business operations, class action and mass tort, court reporting, eDiscovery, regulatory, compliance, restructuring, and bankruptcy matters. Epiq subject-matter experts and technologies create efficiency through expertise and deliver confidence to high-performing clients around the world. Learn more at .


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Protesters are still celebrating in the streets of Yerevan after 10 days of demonstrations forced Armenia's longtime leader Serzh Sargsyan to step down on Monday. But amid the jubilation there is growing anxiety over whether the resignation will bring real change.
It was a rare victory for people power in a region dominated by authoritarian strongmen like Russia's Vladimir Putin and Turkey's Recep Tayyip Erdoğan, who have sought to crush demonstrations challenging their rule.
But for Armenia's democrats, the real work begins now. The protesters are anxious to see whether the party of president-turned-prime minister Sargsyan will try to maintain its grip on power.
Opposition lawmaker Nikol Pashinyan, who organized the demonstrations — he dubbed it a "velvet revolution" after the peaceful protests that ended one-party rule in Czechoslovakia in 1989 — called on protesters not to rest on their laurels following Monday's news.
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"It became obvious they would succeed, because the pressure on Sargsyan to resign was enormous" — Anahit Shirinyan, analyst with Chatham House
"The velvet revolution we've declared must not remain incomplete," Pashinyan told a rally in Yerevan's central Republic Square on Monday night, after Sargsyan stepped down. "It must continue until the end."
"Sargsyan resigned. That's happened. The National Assembly must now appoint a people's candidate for prime minister," he added. "After this appointment, a caretaker government will be formed, followed by snap parliamentary elections."
Sargsyan ruled as president for a decade, then stood down on April 8 in accordance with Armenia's two-term limit. For years, he had promised not to run for either president or prime minister after his second term.
But following a referendum in 2015, Armenia transitioned from an executive presidency with Sargsyan at the helm to a parliamentary system led by the prime minister and his Cabinet.
The parliamentary system came into force last week with the appointment of a new prime minister — and despite all his pledges not to run, Sargsyan was announced as the ruling party's sole candidate for the post.
The liberal opposition was incensed, accusing Sargsyan of implementing the system change to circumvent the two-term limit. Armenia's citizens were furious too, taking to the streets in Yerevan and other cities ahead of the vote.
The protests paralyzed the capital, as crowds blocked traffic and stormed state institutions. On April 17, Armenia's parliament — which is dominated by the ruling Republican Party — elected Sargsyan as prime minister.
In the meantime, police were trying to disperse the protesters. But the demonstrations grew in size and escalated on Sunday, when the authorities arrested Pashinyan and other protest leaders.
"That was the turning point," said Anahit Shirinyan, a Yerevan-based analyst with Chatham House. "Even more people poured into the streets. Then it became obvious they would succeed, because the pressure on Sargsyan to resign was enormous."
'There will be pushback'
After Monday's celebrations, Tuesday began on a more somber note as the country marked the 103rd anniversary of the Armenian genocide.
After that, however, the focus will shift to the future: On Wednesday, Pashinyan is set to meet Karen Karapetyan, the former prime minister who is now back in the job on an interim basis.
The opposition is demanding a new election and structural reforms to ensure lasting change. And with Sargsyan gone, Armenia's victorious protesters are unlikely to accept the status quo, said Shirinyan.
"They weren't just against Sargsyan. They were against the system, against oligarchy and corruption," she said, adding that she was "cautiously optimistic" about the protests' potential to drive profound reforms.
"The protests were only one step on the road to greater democracy and a more liberal system," she said. "It won't be easy. There will be pushback."
Whether Karapetyan and the Republican Party will agree to a new election remains to be seen. The ruling party currently holds a majority in parliament together with a subservient coalition partner.
The outcome of snap elections is difficult to predict, as recent elections have been marred by allegations of widespread fraud. Pashinyan's opposition bloc is tiny, holding only nine of 105 seats, but the protests have boosted his popularity.
"I think these protests are a perfect example of how grassroots people power is able to achieve results with civil disobedience and decentralized protest" — Anahit Shirinyan
The opposition leader has won praise for his insistence on nonviolence and civil disobedience. Though dozens of people were injured, the demonstrations were largely peaceful.
The protests also attracted a diverse crowd: Even soldiers joined the demonstrations in their uniforms.
"I think these protests are a perfect example of how grassroots people power is able to achieve results with civil disobedience and decentralized protest," Shirinyan said. "It can be used as a model in the future."
Crumbling peacefully
The success of the demonstrations might have rattled authoritarian leaders in the region, but analysts are warning against applying a geopolitical filter to Armenia's protests.
Thomas de Waal, a senior fellow at Carnegie Europe, writes in an opinion piece for Foreign Policy that the protests are unlikely to create repercussions beyond Armenia's borders.
Sargsyan's resignation has prompted a flurry of think pieces wondering whether the Armenian leader's downfall could weaken Putin. A Washington Post editorial even declares that Armenians have delivered "a blow to Putin's political model."
Armenia has moved closer to Moscow under Sargsyan, joining Russia's Eurasian Economic Union in 2013, thereby thwarting negotiations for an association agreement with the European Union.
De Waal, however, notes that the protests had nothing to do with Russia, which has already come under criticism in Armenia for supplying arms to neighboring Azerbaijan. Moscow, in turn, has avoided wading in on the issue beyond expressing hope for order and stability.
Meanwhile, Armenia signed a partnership deal with Brussels last November — also under Sargsyan's leadership. The accord, which aims to strengthen cooperation between the bloc and the Caucasus nation, has yet to be ratified by most EU member countries.
"Sometimes, as in Armenia these past several days, government-toppling protests are just government-toppling protests," De Waal writes.
"At most, it is a sign that post-Soviet regimes are not as secure as they look from a distance and that the region's old regimes are perfectly capable of crumbling peacefully without any push from the outside."


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It is rare for a fossilized egg to retain its embryo. Even more so when it comes to the 90 million year old tortoise egg. Yet this is a discovery made by Chinese researchers.
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[EN VIDÉO] Ancient turtle fossils Polish researchers have formalized the discovery of ancient tortoise fossils dating back 215 million years.
One Embryo The image of the tortoise and properly preserved in an egg. All are about 90 million years old. Before the dinosaurs disappeared. This is an incredible discovery Wuhan University researchers (China) report today.
Keep in mind that finding a fossil embryo is rare. This is because the tissues and bones of the developing animal break down easily over time. The Turtle eggs Be common Bombs The thinner it is the less it protects the embryos in them. But its discovery allows researchers to believe that others will find it.
The egg was discovered in the summer of 2018 by researchers at a farm in Henan province in central China. Size and shape of billiard ball – 5.4 and 5, 9 cm in diameter. There is no similarity with Dinosaur eggs They are often found in the region. But the two thin bones came out of a crack and caught their attention. They first believed in a new type of dinosaur.
Incredibly dense tile egg
Later, the researchers examined the material with computed tomography (CT) X-rays Really lets you look behind the egg. They discovered the problem of the bones. To understand who these bones belong to, they were reconstructed one by one in 3D. And they put them together in a small skeleton … the tortoise.
Some key features – a slightly square upper jaw and a severed posterior margin, for example – allowed researchers to identify which family this little tortoise belonged to. And precisely, in Thing, Not the word petty. Because the fetus was a fetus Eucalyptus nunciungselitz, A giant land turtle that lived in the time of the dinosaurs. Imagine it until a man is tall!
Among the surprises revealed in the study: The thickness of the egg shell: 1.8 mm. About four times more than that Geochelone Yanaibus, A The giant Galapagos tortoise Still known to produce particularly thick eggs. Researchers do not know why. Maybe an adaptation Weather This time it is dry, intended to retain water in the egg. But one thing is for sure: the little turtles of the time had to fight hard to see the daylight.
The thickness of these shells may have contributed to the disappearance of these giant turtles along with the dinosaurs. They rarely adapted themselves to the new environment they createdMeteor impact.
Are you interested in reading now?


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Extend Your Summer With CRMUG & GPUG Summit 2016
Posted on: August 15, 2016 | By: Craig Thompson | Microsoft Dynamics CRM, Microsoft Dynamics GP
Are you a Microsoft Dynamics GP or CRM user wanting to delay another cold Chicago winter just a little longer? Sound impossible, yet intriguing? Luckily, your Microsoft Dynamics Partners at Logan Consulting have the perfect solution that not only lands you in Tampa for a weekend, but also enhances your CRM knowledge base. What's not to love!
This year's CRMUG and GPUG Summits run from October 11-14 and will be held in Tampa Florida. Join us this October and further develop your knowledge of CRM through innovative keynote speakers, product roadmaps, focused learning and valuable networking opportunities to grow your business and gain solutions to everyday Dynamics CRM and Dynamics GP challenges and goals. This premier user focused conference is sure to change the way you view CRM – in a new positive light.
For more information on the conference and how you can register, check out the GPUG and CRMUG websites. Want to learn more about how Microsoft Dynamics CRM or GP can transform your day to day business operations for the better? Contact Logan Consulting, your Chicago based Microsoft Dynamics partners for a consultation.
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text: Etteplan acquires the entire share capital of Swedish ProAvia Konsult AB Stock exchange release - Published: 09.01.2014 - 15:00:00 Back to Releases ETTEPLAN OYJ, STOCK EXCHANGE RELEASE, JANUARY 9, 2014, AT 3:00 P.M. ETTEPLAN OYJ, STOCK EXCHANGE RELEASE, JANUARY 9, 2014, AT 3:00 P.M. ETTEPLAN ACQUIRES THE ENTIRE SHARE CAPITAL OF SWEDISH PROAVIA KONSULT AB Etteplan Oyj has signed today an agreement to acquire the entire share capital of Swedish ProAvia Konsult AB. The company, founded in 2003, provides services in the field of systems engineering targeted especially to defense industry. ProAvia employs about 30 people and it has offices in Stockholm and Linköping. The acquisition strengthens Etteplan's market position and expertise in the area of demanding systems engineering and creates better growth opportunities for Etteplan. With the acquisition, Etteplan becomes one of the largest companies providing systems engineering in Sweden. The acquisition enhances Etteplan's opportunities to offer services to aerospace and defense customers also outside Sweden. Juha Näkki, President and CEO of Etteplan Oyj: "The signed agreement follows Etteplan's strategy to increase its expertise to meet customers' needs better. Etteplan has worked with ProAvia for several years and the acquisition is a natural extension to our well-working co-operation". The acquisition has a minor effect in Etteplan Oyj's financial result in 2014. Vantaa, January 9, 2014 Etteplan Oyj Board of Directors Additional information:Juha Näkki, President and CEO, tel. +358 400 606 372 DISTRIBUTION:NASDAQ OMX HelsinkiMajor mediawww.etteplan.com Etteplan provides engineering planning services and technical product information solutions to the world's leading companies in the manufacturing industry. Our services are geared to improve the competitiveness of our customers' products and engineering processes throughout the product life cycle. The results of Etteplan's innovative engineering can be seen in numerous industrial solutions and everyday products. In 2012, Etteplan had a turnover of EUR 134.5 million. The company has more than 1,700 professionals in Finland, Sweden, the Netherlands and China. Etteplan's shares are listed on NASDAQ OMX Helsinki Ltd under the ticker ETT1V.


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Cabinet departments propose new paths to apprenticeships
A joint task force led by the U.S. Departments of Commerce, Education and Labor have issued a set of 26 policy recommendations designed to make apprenticeship programs more accessible and more effective.
The final report of the Task Force on Apprenticeship Expansion, released May 10, proposes a five-year plan to create "a pathway to new, industry-recognized apprenticeships," according to Labor Secretary Alex Acosta.
Read the report at www.dol.gov/apprenticeship/docs/task-force-apprenticeship-expansion-report.pdf.


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Enjoy the beautiful voice of Gad Elbaz for an uplifting KABBALAT SHABBAT service.
October 27
5:55 PM Mincha (Afternoon Service)
6:10 PM Kabbalat Shabbat
Ner Tamid Congregation
6214 Pimlico Road
Continue the celebration after dinner with a community-wide SHABBAT ONEG. Enjoy light refreshments, singing and Shabbat inspiration!
October 27
Congregation Shomrei Emunah
6221 Greenspring Avenue


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Visitors from China
Wu Xinlei, counselor from Nanjing University, and Lin Zhu, (at right) graduate student in photoelectrical engineering from Nanjing University are on campus for a two-week visit. In this photo they're looking for Kennedy Union from Humanities Plaza. Their umbrellas are shielding them from the hot southern Ohio sun.


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Congratulations to Friends of Badger Mountain on being named the Regional Chamber's Member of the Month for June 2021.
The Friends of Badger Mountain group is an all-volunteer organization that was founded in 2003 and has been an active member of the Regional Chamber for many years. The group has preserved over 900 acres and built and maintained 10 miles of trails.
The trails that the group work to build and maintain were able to remain a bright spot during the pandemic where people could get out and be active. In fact, over 300,000 users were counted during that time!
The group is now under a current campaign to raise money to create the third reserve – little Badger Mountain Preserve. They are also working on an exciting new development – Red Mountain Vineyard Trail - as a partnership with the Red Mountain AVA – the first vineyard trail in the U.S.
Congratulations on being named our June Member of the Month!
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September 2023
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Home > Trending > Products
Scientifically proven to increase comfort and relieve foot pain.
May 16, 2022 | By Mr. Tom L. Bavlsik, PhD, MD
With 15.000+ verified 5 star reviews, what is it about these sandals that makes waves of women buy these?
Many times when it comes to comfortable footwear, people usually tend to go for these big brands like Sketchers, New Balances, Adidas and more...
But when masses of women started buying the ComforthoFit sandals like they were the holy grail, analysts wondered:
What is going on? What makes these sandals so special?…
How could a small local orthopedic brand be taking over the biggest names in the industry?
After studying the sandals concepts and materials, analysts came to 5 conclusions, on why women cannot resist getting a pair for themselves.
1. Extremely Lightweight - Only 150g per Sandal!
The average weight for a standard sandal is 350-500g+. When you are on your feet for a long time at once (for example during a 12 hour shift), this weight adds up and can be extremely harmful for your feet, if your footwear does not support a healthy foot posture.
The ComforthoFit™ Sandals have less than 150g per shoe and it literally feels like you are walking on clouds.
>>> Click here to secure a pair for yourself, before its out of stock!
2. Get Rid of Bunions, Arthritis, Corns, Plantar Fasciitis!
The Sandals have premium orthopedic insoles with an arch booster to support the natural shape of your foot and help with common foot pains.
With our stretch knit material and ergonomically designed sole, your bunions pain will quickly disappear when wearing the shoes.
>>> Click here to secure a pair for yourself, before its out of stock!
3. The Perfect Summer Shoe
There have always been certain orthopedic footwear products on the market, but specialists call the sandals from ComforthoFit "revolutionary" and the solution to modern foot pain.
The sandals have a sole so soft and comfortable, it literally feels like you are walking on clouds.
Due to the breathable material, the shoes are perfect for the warm summer days coming. These shoes have forever solved the problem of sweaty feet on sunny days.
>>> Click here to secure a pair for yourself, before its out of stock!
4. It Adjusts Quickly To Every Foot
The ComforthoFit shoes have been designed elastically to adjust to each foot individually.
Finally you can get rid of foot problems like Calluses, because these shoes handle your feet much more carefully.
The extremely soft premium material used for these shoes makes it possible to adjust to each individual foot size.
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Experts in the industry have been recommending these sandals to anyone having foot problems and for those people who have to spend a lot of time standing/walking on their feet. Try them out yourself!
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Click the button above to check if the sandals are still available.


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There are no employment opportunities at this time, please come back regularly as our service is growing.
Connected Libraries (CL) is one of Victoria's largest public library services. We are funded principally by City of Casey, and the State Government. We support a rapidly growing and diverse community of more than 460,000 people.
CL have a shared vision, mission and values that are absolutely vital to our success. They define who we are and how we operate.
At CL we value our staff and encourage them to strive to be the best they can, using their strengths every day.
We want CL to be a great library service where people (staff and customers) feel valued and appreciated. Our team work in libraries because they really care about their community and want to make a difference.
Connected Libraries (CL) is a child safe and child friendly organisation committed to ensuring that all children who visit our libraries have the right to feel and be safe.
CL values equal opportunity and strives to create an inclusive and welcoming work environment that represents the diverse community we service. We strongly encourage applications from Aboriginal and Torres Strait Islander people and people of all abilities, cultures, age, sex and gender.


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Giving up or Pursuing Translation? The Impact of Strategic Competence on Motivational Persistence / Çeviriye Tamam mı Devam mı? Stratejik Edincin Motivasyonel Kararlılığa Etkisi
This study aims to analyse the strategic competence that Translation Studies students develop during the translator training process according to some variables and to explore its impact on the pursuit of translation goals. Research data was collected using the Metacognitive Learning Scale developed by Namlu (2004) and the Motivational Persistence Scale adapted into Turkish by Saricam et al. (2014). Research is conducted with 214 students enrolled in the English, French and German departments of Translation Studies in a public university using the relational screening model and correlational survey method. Results show that trainee translator's strategic competence does not vary by department or class but by gender, age and academic achievement. General strategic competence and planning strategies of female translator candidates were higher than males and students' strategic competence mean is slightly above the average. Another result was that when strategic competence increases, motivational perseverance increases accordingly. Furthermore, students using planning strategies or organizational strategies are more likely to pursue current and distant translation goals. Students using supervision or evaluation strategies on the other hand, can return to unresolved past goals in addition to going after current and long-term translation goals.
Anahtar Kelimeler
Tam Metin:PDF (English)
Ağbuğa, B. (2017). Comparison of metacognitive learning strategies of female and male university students. International Journal of Social Sciences and Education Research, 3(3), 783–791.
Akdağ, A. I. (2016). Fransızca Çeviri Eğitiminde Hedefler. Eğitim ve Öğretim Araştırmaları Dergisi, 5(2), 66–73.
Akın, A., & Abacı, R. (2011). Biliş ötesi. Ankara: Nobel Yayın Dağitim.
Angelelli, C. V. (2012). Teaching Translation and Interpreting. The Encyclopedia of Applied Linguistics. https://doi.org/10.1002/9781405198431.wbeal1176
Angelelli, C. V., & Jacobson, H. E. (2009). Testing and Assessment in Translation and Interpreting Studies: A Call for Dialogue between Research and Practice. Amsterdam/Philadelphia: John Benjamins Publishing Company.
Argon, T., İsmetoglu, M., Çelik Yılmaz, D., & Erbaş, H. (2015). High school students' views on lifelong learning and motivational persistence levels. ICLEL 1 t International Conference on Lifelong Learning and Leadership for All October 29th -31st 2015 Palacky University & Moravian University College Olomouc, 35. Retrieved from https://www.researchgate.net/profile/Osman_Titrek2/publication/301342510_ICLEL_15_Conference_Prooceeding_Book_ISBN/links/5713666708aeff315ba33d87.pdf#page=48
Baykara, K. (2011). A study on "teacher efficacy perceptions" and "metacognitive learning strategies" of prospective teachers. Hacettepe University Journal of Education, 40, 80–92.
Beeby, A. (2000). Evaluating the development of translation competence. Benjamins Translation Library, 38, 185–198.
Beeby, A., Fernández, M., Fox, O., Hurtado Albir, A., Kozlova, I., Kuznik, A., … Wimmer, S. (2009). Results of the validation of the PACTE translation competence model: Acceptability and decision making. Across Languages and Cultures, 10(2), 207–230. https://doi.org/10.1556/acr.10.2009.2.3
Beeby, A., Fernández, M., Fox, O., Hurtado Albir, A., Kuznik, A., Neunzig, W., … Wimmer, S. (2011). Results of the validation of the PACTE translation competence model: Translation project and dynamic translation index. In Cognitive explorations of translation (pp. 30–53). Retrieved from http://grupsderecerca.uab.cat/pacte/sites/grupsderecerca.uab.cat.pacte/files/2011_PACTE_Continuum.pdf
Beeby, A., Rodríguez, M. F., Fox, O., Hurtado Albir, A., Neunzig, W., Orozco, M., … Romero, L. (2003). Building a translation competence model. In Triangulating Translation: Perspectives in Process Oriented Research (Vol. 45, pp. 43–69).
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May 22, 1999
Finding the Blind Spot
There's nothing like a good visual demonstration to get your attention. Apparently several of you couldn't see the blind spot. If it still hasn't worked for you, you might want to go to the second website I mentioned and print out the dot and cross (or just draw them on a sheet of paper yourself) and do the experiment with the hard copy. Here is the internet LINK
Rest assured all people do have a physical blind spot.
I'm glad readers enjoyed Samu's excellent presentation on this subject.
Let me quote him:
"Usually the existence of this spot is difficult to notice, because the eye is normally constantly moving and absorbing light from different objects around us, thus the area that is unseen because of the blind spot changes all the time, and the brain is able to create the illusion of a full picture."
Notice that Samu states that we have the illusion that there is no blind spot, but that we are seeing the whole picture because " the eye is normally constantly moving and absorbing light."
As above so below applies here. Just as we have a physical blind spot even so do we have blind spots on several higher levels. I'll add a few additional insights here.
First: Where are the additional blind spots located on the higher levels?
The next level up is the astral which governs our lower emotional feelings which supplies over 90% of the emotions felt by the average person.
You have heard that "love is blind." Higher spiritual love is not blind, but regular emotional love creates some very hard to see blind spots. We have all seen a friend who is newly "in love" with someone we see is obviously a creep.
Why, we wonder can this person not see what he or she is getting into?
The answer is simple. By focusing on the one object (lover boy) she becomes blind to other faults circulating around the guy.
Some of have seen an abused spouse who gets the hell beat out of her again and again. Nevertheless, she keeps her eyes focused on the love that was and refuses to believe she is in danger and stays with the guy on her own free will.
The next level up is that of the mind. You may have heard the ancient statement that "the mind is the slayer of the real." Why would this be so? Isn't what the mind reveals a true reality? Basically it is true that the mind is a reliable guide except for one thing. The mind has a blind spot and within this blind spot the mind has no perception.
This point of no vision in the mind causes it to put together conclusions that are not whole (or holy).
We have all met the intellectual who just about drives us crazy with his big words and encyclopedic recitations, yet he seems to never make much sense. He sounds intelligent, but he never turns on that light of truth within our spirits. Often his conclusions just don't ring true to us even though he seems very positive about them within his own little world.
A person may be very educated and logical, but if he has a flaw (blind spot) in his foundational belief system then many of his conclusions will be wrong.
Example: Using the mind alone an intellectual cannot prove there is a God, higher beings or life after death. If he thus concludes that life began at birth and ends at death, he will be blinded to over 90% of the truths available to mortal man.
On a personality level as a whole most of us have blind spots. Let me tell you one that I discovered in myself.
When I was a teenager I loved the early sixties music. I used to memorize many of the songs (Del Shannon was my favorite) and sing them around the house. At the time I thought I had a great voice. When I listened to myself it sounded pretty good to me. In fact I thought I could sing the songs about as good as the original artists. What amazed me is that my Mom, Dad and Sister constantly complained about my singing. I could not understand this complaining and wrote it off as a lack of appreciation for modern music. I ignored them and kept on singing thinking that eventually they would learn to like the songs as I had.
Then my Dad reached a point where he had enough and borrowed a tape recorder from a friend and brought it home. In those days it was a novelty to have a tape recorder and up to that point I had never heard my singing voice played back to me.
He approached me with a mike and said: "Now sing that favorite song of yours."
I was eager to hear my "beautiful" voice so I sang my favorite song ""Runaway" for the family. It demanded a falsetto so I thought I would really sound impressive.
After I finished the song my Dad played it back to me with a knowing grin on his face. I couldn't believe my ears. I thought I was in the Twilight Zone. Surely the person on the tape couldn't be me. This voice on the tape sounded terrible and when I hit the falsetto the whole family justifiably laughed at my strange attempt.
After the tape was played and the "blind spot" about my voice was revealed no one had to yell at me to shut up again. My ego was taken down several notches and I realized that my singing voice had much to be desired.
I still loved popular songs and continued to sing them when no one was around. Then I eventually got my own tape recorder and practiced singing into it. Hearing my true self on tape allowed me to truly work on improving my voice. Later I took some singing lessons. My teacher told me that I was her greatest challenge. During this time I probably tripled the quality of my singing voice. It went from terrible to about average, but I was grateful for the improvement.
The interesting thing about this experience is that through the use of outside viewpoints and an external player I was able to neutralize the handicap of my blind spot. Then through the use of a teacher with greater knowledge and ability than I had, I was able to make considerable improvement. I realized that there were no limits to the amount that I could improve in this area, but my interests started going in other directions so I am stuck with an average voice – and grateful for it.
This story should help us discover our blind spots on the various levels. When I heard family and friends complaining over and over about my voice, that should have told me something.
When the person in love hears from all family and friends over and over, "that guy is a creep and is no good for you," maybe they are seeing something you are not.
When the dreamer comes up with ideas that sound great to him, but make no sense to anyone else, maybe there's a reason they make no sense.
When Romeo thinks he's a lady killer, but all the ladies go out of their way to avoid him, maybe there's a reason for it.
We all know people with obvious blind spots to the extent that it seems to be a great mystery as to why they cannot see the fault in themselves.
Many New Agers tell us that everything is "within," but concentrating on going within will not eliminate the blind spot. It can only be discovered by going without. We must listen and consider comment and evidence from without (the tape recorder) and play it back and see how that which was without compares to that which seems to be within. As in the case of my voice there may be a stark difference. If there is we must be open to the possibility that we have a blind spot that needs to be revealed. Only when we become completely open to this possibility can we discover the real truth and begin to make some improvement.
For many, achieving the average is nothing to be excited about, but because of my struggle with my voice I was more satisfied to have an average voice in the real world than I was when I had a superstar voice in my imaginary world.
There is just something about a real achievement in the real world that is much more satisfying than quantum leaps in an illusionary one.
The within part of ourselves is never going to come forth and broadcast the blind spot to us. We must listen to the complaining and contrasting voices without and where there is consistency and repetition there may be an opportunity of self discovery.
This is what we must do. Not see an insult, but opportunity.
We must also remember that there are extremes in all things and on the other end of the spectrum there is the danger that one or two inconsistent voices can convince us that there is a blind spot that does not exist. Becoming convinced of a phantom blind spot can become as big of a handicap as ignoring the real blind spot.
For instance, a reader, the other day expressed concern about my ego and motive. This did little, however, to make me believe that a blind spot was being revealed. Why is this? Because after thousands of postings this was the first one to express concern about my ego.
A second reason that I did not take it seriously is that there were no specifics mentioned as what I have done that is egotistic.
Now, if a number of group members who have grown to know me started telling me with repetition that they are concerned about my ego and are able to give reasons why, then I should at that point consider that I have a blind spot in that area. If I were to be suspicious with myself I should ask my wife and friends what they think about my ego. If I get a few responses that harmonize with the group then I need to take it seriously.
The alcoholic is a great example of one who has a big blind spot. Many of them who are in big trouble will just not admit they have a problem. Often times the only way they become convinced is when all their family and friends gang up on him and all relate, one by one, the same observation, that the guy indeed has an alcohol problem and it is ruining all his relationships.
Even this does not always work, but it does at times. When successful, the alcoholic finally faces the fact that so many voices saying the same thing cannot be entirely wrong.
Like the alcoholic we often resist with great effort any outside attempts to reveal our blind spot. Outside of our blind spot we may be geniuses, but within it we may appear to be blathering idiots to those who see truly and take pity on us.
Questions: Do you think that we can retain our blind spots and still attain spiritual enlightenment?
Do you know of people who believe themselves to be enlightened that have obvious blind spots?
Copyright by J J Dewey
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By Carol Pratt, Child Guidance Clinical Intern
Suicide awareness month happens every September, but for us, suicide awareness and prevention is EVERY month. Today, we're going to talk a bit about the risk factors for suicide, the things to look out for, and more. Suicide can be a scary thing to think about or to address. However, it's a global epidemic. And, for each completed suicide, there are an estimated 20 or more suicide attempts (World Health Organization, 2014). That said, it's not without hope.
There are known risk factors for suicide which can help with prediction. Feelings of helplessness, sadness, anxiety, and negative affect, for instance, are known to be associated with suicidality. Stressors resulting from past impulsive or avoidant behaviors (e.g., accruing a large debt) are also known risk factors (Brown & Chapman, 2007). We'll talk a bit about more things to look out for in the list below. Merely relying on known risk factors, however, may not be enough for prevention strategies to be successful (Franklin et al., 2017). For example, even seemingly important cues, such as talking about suicidal ideation, may only be present in some: only around 40% of people who die by suicide express suicidal thoughts at an earlier time. The more we know about suicide and the signs that lead up to this life-ending action, the more we can prevent loss and help people get the care they need.
A few other warning signs of suicide include:
• Increased substance use
• Aggressive behavior
• Withdrawal from friends, family and preferred activities
• Dramatic mood swings
• Impulsive or reckless behavior
• Collecting and saving pills or buying a weapon
• Giving away possessions
• Tying up loose ends, like organizing personal papers or paying off debt
• Saying goodbye to friends and family either through text, letters, or verbally.
Suicidal behaviors are an emergency. If you or a loved one starts to show any of these signs, it is critically important to get immediate help from a healthcare provider or call 911 and go to the emergency room. People who have survived suicide almost always talk about how thankful they are that they did not die and were able to get help to address the root issues leading to their suicidal ideation. We want to help people who are struggling get to safety and get enough support and space so they can recover and live a full, life. Suicide is a permanent solution to a temporary problem.
Devastatingly, too many people die by suicide without ever sharing their thoughts or expressing their feeling that they need to die. While suicide is rarely without warning signs, they can very easily be missed. Why might someone keep these thoughts secret? Stigma is a HUGE part of this. Concerns about embarrassment (62.2%), being judged (55.4%), worrying others (54.7%), and others finding out (54.7%) were the most commonly reported reasons for why participants did not accurately disclose their suicidal thoughts (Horvath, A., Dras, M., Lai, C. C. W., & Boag, S.,2021). There can also be fears about having to be hospitalized or to let their loved ones down. Suicidal thoughts are scary and overwhelming; it can be very difficult for individuals struggling to make logical decisions or look to the long-term benefit of the short term discomfort (NAMI).
Who is at "risk" for suicide? While there is no specific look or description – anyone and everyone can struggle with suicidal idewation – research HAS found that 46% of people who die by suicide had a known mental health condition. Other things may put a person at risk of suicide, including:
A family history of suicide
• Substance use. Drugs can create mental highs and lows that worsen suicidal thoughts.
• Intoxication.
• Access to firearms or other lethal items like pills
• A serious or chronic medical illness
• Gender. Although more women than men attempt suicide, men are nearly 4x more likely to die by suicide with the risk highest in middle aged white men.
• A history of trauma or abuse
• Prolonged stress
• A recent tragedy or loss
Suicide prevention is up to ALL of us. The more we know, the more we talk about it, and the more we work to increase access to care, the more lives we can save. Remember, most of the people who either attempted or completed suicide make their intentions known ahead of time through language or other clues. Because of this, ANY talk of suicide should not be ignored or taken lightly. There is always hope. Even intensely depressed people generally want to end the pain they are in, not their lives. Often times, when a person in crisis gets the professional help in time, they will never be suicidal again. Suicide can be prevented in most cases and small acts of outreach and kindness can save a life. That said, if you lost a loved one to suicide and did not see the signs – know that this is not your fault. If you are struggling with suicidal ideation, have lost a loved one, or want to learn more, we have shared some resources locally and nationally below:
- Delco Suicide Prevention Taskforce
- Prevent Suicide PA
- Support Group at Bryn Mawr Hospital
Contact Person : Gail Dohrn
Additional Information : Meets in Warden Lobby
- Main Line Health Center
3855 West Chester Pike (PA Rte 3)
Newtown Square, PA 19073
Meets in Community Room C
- Riddle Memorial Hospital
1068 West Baltimore Pike
Media, PA 19063
Meets in the Community Education Center
- Hope for Hallie organization - provides short term mental health access to teenagers In partnership with Thriving Families Center.
- Suicide Prevention Hotline (national, 24 hours, 7 days a week)
About the author: Carol Pratt is an intern at Child Guidance, obtaining her Bachelor's of Social Work from Liberty University. She is a mother of 4 and is a strong advocate for individuals to help them live their best life.


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Normally I'd never take note of something like this. It's a cute little time-filler all through a sports activities broadcast and warrants no similar recognition. Then I noticed an up-close shot of the cake. There are not sufficient hours inside the day to keep the number of questions I even have approximately this listless, despair birthday cake left to die on a press box desk after A-Rod and J-Lo left the construction. I have those questions due to the fact I recognize this cake properly.
I've seen its type before. This is a spice cake. It turned into bought from a grocery store, quickly earlier than remaining time. It was probable partially frozen, thawed with the assistance of a car seat hotter at the power to a ballpark. Its nondescript message and overwhipped frosting are telltale symptoms of an ultimate-2d buy. The wisest factor anybody did concerning this cake was no longer devour it.
Still, I actually have questions.
I'm assuming J-Lo has a private assistant whose activity it's miles to address this kind of aspect. Why didn't they go to a bakery? Commission a cake? Heck, setting a few frosting on a dozen donuts likely would have appeared to find it irresistible took more effort than this glum, moribund sheet cake. Was this simply now not deliberate out at all? I dare to posit that Lopez had nothing to do with this sorrowful, barren, unhappy sponge.
I need to trust this changed into a last-second manufacturing choice. I cannot fathom that this cake became J-Lo's doing. Listen intently to that video again. The cake is slightly in the frame, and she, or he's already subtly telling A-Rod that she had not anything to do with it.
This is from your ESPN circle of relatives.
Humans are a simple bunch. We love taking credit score for accurate matters and are quick to make sure we're blameless when something terrible, like a nondescript sheet cake, happens. She's letting him realize, in front of the world, that she might by no means deliver this sort of cursed object to him — in particular in honor of his birthday.
Sportswriters will consume peanut butter smeared on a playing card and contact it at lunch. I witnessed someone (who shall no longer be named) make a towering nacho plate out of sliders in the Super Bowl LIII mess corridor. Free meals to sports activities writers are like an open trash can to a military of hungry raccoons. One time an idiot who works for this site even ate everything concessions became promoting at a carrying occasion because he has no dignity.
Look, I get it; the corner pieces are a top actual estate for the frosting-conscious cake gourmet — however, going contrary nook for the slice and breaking convention is just bizarre, especially for this cake. I love this attitude because it confirms each suspicion I had about this cake. There's not anything unique lurking inside—no hidden surprise. Just a bathroom-widespread, dull, white sheet cake with uninspired frosting served room-temperature to be wolfed through folks who value free meals over quality. I close with a brief lesson for ESPN: As someone who is a past life become chargeable for shopping for office desserts, I ought to tell you that cheesecakes are your pal when you want to look like you're showing effort but still need to shop for it fast from a grocery shop. They feign effort higher and received't dry out on set.
Refrigerate the cake until the icing units, approximately 10 minutes.
Apply a very last thick coat of icing to the top and the edges, following the steps above, ensuring that the coat is even and smooth. When icing the sides, apply a coat thick enough to cover and disguise the cardboard spherical. Dipping the spatula into hot water will assist create a clean coat. As you ice the pinnacle and sides, a ridge will shape alongside the edge they meet. After you've finished icing, preserve the spatula at an attitude and, with a very mild hand, starting at the farthest edge of the cake, smooth the ridge in the direction of the center. Rotate the cake and repeat until the ridge not exists.


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Israel Releases Post Packages for Palestinian Territories
Israeli authorities released on Thursday a large shipment of postal packages sent to the occupied Palestinian territories, from abroad.
A statement, released by the Palestinian Authority's (PA) Ministry of Telecommunication and Information Technology, said that the released shipment includes posts, delivered directly by three new countries to the Palestinian Authority's postal department.
"For the first time, the new shipment involves posts, delivered directly from three new countries, increasing the number of countries that already deal directly with the Palestinian Authority, to eight", the statement explained without identifying the countries.
Upon arrival of the shipment that contains 1600 postal packages, the concerned Palestinian post authorities subjected all packages to necessary sterilization, in light of the current internationally-spread Coronavirus.
The packages will be delivered to various destinations in both the West Bank and Gaza Strip, by next Sunday.
Often, according to Palestinian sources, Israel, the occupying power, delays delivery of postal items shipped to the Palestinian territories, from abroad.