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The amount of copy devoted to Isetan-Mitsukoshi in recent months is the result of the pace of change and innovation at the formerly dowdy department store group. As well as small stores and services like travel and health clinics, the group's latest ideas emphasise its determination to reach out to customers wherever they are. This includes crowdfunding new projects, new stores in Europe, more stores at home and more online marketing.
Just a month after opening the first in a chain of 10 Isetan Salone stores and launching test stores in Osaka for mid-market accessories and fashion chains, Isetan-Mitsukoshi has now confirmed plans to target foreign customers, both at home and overseas.
Although Mitsukoshi once operated stores in London serving flocks of Japanese tourists, Isetan-Mitsukoshi will now launch proper retailing in Europe for the first time. The first store will be an 87 sqm select shop in the Japanese Cultural Centre in Paris that will open this Autumn as part of the wider campaign to promote Cool Japan. It will focus largely on Japanese brands and design; Isetan already promotes Japanese design in the domestic market through its project 'This is Japan'. Once the store has been tested, Isetan-Mitsukoshi plans to open similar small format stores across Europe in key cities, a major step in promoting the Isetan brand overseas.
Isetan-Mitsukoshi trialled an overseas boutique in 2013, using a pop up store in New York called "Nipponista" with the tag line, 'Fashion, Art, Design'. This winter Isetan will also remodel and rebrand its Malaysian store, offering a broad range of Japanese fashion, interior design and other craft brands.
At the same time as expanding overseas, Isetan-Mitsukoshi is working hard to pull in tourists at home. Key to this will be its new 3,300 sqm duty free store in Mitsukoshi Ginza due to open this Autumn. The eight floor store will focus on luxury fashion and cosmetics brands, with tourist customers able to pick up their purchases at the airport. The group expects the dedicated space to help Mitsukoshi Ginza increase sales from ¥74 billion last year to ¥100 billion.
At the same time, Isetan-Mitsukoshi's small format store division continues to look at a variety of formats to see what works where within the domestic market. The aim is to design stores suited to particular customer targets, rather than fix on specific formats and look for locations to suit.
The latest result of this process is a plan to launch a men's only select shop chain, with the first due to open in Marunouchi in December. Located on the street level of Shin Tokyo Building and targeting the large number of prosperous businessmen in the area, the 900 sqm store will be a men's version of Isetan Salone and similar to the men's store at Haneda Airport.
The store makes a lot of sense, expanding on the success of Isetan Shinjuku's men's annex; in other words it is yet another way to extend and exploit the considerable latent potential of the Isetan brand across multiple formats, taking the stores to customers rather than hoping they will make the trek to the Shinjuku flagship.
Isetan Salone, the men's store and the upcoming 3,000 sqm store in Nagoya, are just the start of a programme that will see at least 10 select shops opened through 2018 with sales projected at around ¥10 billion. In addition, Isetan-Mitsukoshi expects to have six airport stores by then.
Isetan-Mitsukoshi's other small format chains are also growing solidly. Since launching in 2012, the cosmetics store Isetan Mirror has grown to 10 stores and will double through 2018, with the next store opening in Tokyu Plaza Omotesando in November. MI Plaza, for senior consumers, now has 70 stores and will also double to 140 through 2018, meaning that the total 'satellite store' business will increase from 92 stores now to 180 through 2018 with sales of ¥60 billion.
Isetan-Mitsukoshi is not just reaching out through stores. It is also tying up with major online partners to attract new customers, particularly to its Isetan brand. Last month it agreed to promote its recently updated Isetan online store through Yahoo! Search, meaning its products now display within Yahoo popularity rankings.
It is even collaborating with convenience stores, agreeing with JR East's NewDays conbini division to host Isetan-Mitsukoshi gift selections in its catalogue. Isetan and Mitsukoshi remain two of the most popular brands for o-chugen and o-seibo gifts, but ordering at stores is inconvenient. By making ordering available at all of JR East's stations it is again taking its brands to customers.
The group has also widened its ties with Cyber Agent. As previously reported, this Spring Isetan began promoting its online store through popular bloggers on Cyber Agent's Ameba in a bid to reach a younger demographic. It will now get into crowdfunding. It has agreed a deal with Cyber Agent's Makuake crowdfunding platform to promote Makuake projects in fashion, design and related services. To do this it will use its event space in Isetan Shinjuku to promote the crowdfunding project, and enlist shoppers to invest.
Isetan says that this will really help bring such crowdfunded projects to life because many potential supporters are sceptical of merchandise-related projects if they can't see and touch the product. Shoppers will be able to see items on display in store, view videos and other promotional material, as well as talk to the founders during special events. Given the store's 25 million visitors a year, being taken on by Isetan should prove a major fillip to many aspiring fashion entrepreneurs.
FOCUS: Apparel Retailing FY2014: making the best of it
Isetan-Mitsukoshi signs up to T-Point loyalty system
Mitsukoshi Ginza ¥4 billion relaunch
FOCUS: Department Stores FY2014: over the hurdle
Digital fashion: 3D virtual fitting and printing your own dress
FOCUS: Retail Industry Performance FY2014: solid results for many as distribution evolution continues
Isetan opens first Salone, plans 10 stores by 2018
Kitsch paradise: Isetan-Mitsukoshi targets young in new Harajuku Alta and online


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The four Geneva Conventions of 1949 form the basis of international humanitarian law. These laws protect persons who are not or no longer involved in hostilities. This includes civilians, prisoners of war and wounded and sick soldiers. 196 states have signed up to the Geneva Conventions to date.
Research & Academia
The criminal investigation into Lumumba's assassination is part of a broader context of structural impunity for the crimes committed by European colonial powers during decolonization. While the long-term effects of colonization persist, direct accountability is rarely possible.
In March 2009, ECCHR partner lawyer Gonzalo Boye filed a criminal complaint against six former US officials of the Bush administration regarding their accountability for violations of international law, including war crimes and torture. The US officials became known as the "Bush Six."

subset: commoncrawl


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Tag: napoleon creative
Discover September 29, 2016 Do you take short cuts when telling your story?
General September 19, 2016 Creating a white board animation in London
Production February 11, 2016 The curious case of the out of focus book case…
Production February 10, 2016 Bringing photographs to life
Animation December 23, 2015 Christmas at Texcel
Deliver October 2, 2015 Show me where to go
Production June 3, 2015 Quick turnaround animation? Yes, we can!
Animation February 12, 2015 What's the harm in an animator/account handler hybrid?
Post-Production January 21, 2015 How to get a great voiceover read
Production October 7, 2014 Getting the details right requires the right prop house


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I wasn't able to watch the PC Gamer press conference but after finally catching up SacriFire stood out among the as the most visually stunning.
SacriFire is an upcoming RPG, inspired by the 90s titles that began our love affair with gaming.
Key Features
- Dynamic battles – Our combat engine merges real-time and turn-based styles to provide a fluid experience that is both challenging and satisfying. Fight alongside companions, choose from multiple weapons, target individual enemy body parts, and string attacks together to create elaborate combos.
- High-quality presentation – Employing both pixel art and 3D graphics allows us to combine retro-style graphics with innovative digital effects wizardry. Hand-drawn and animated characters blend seamlessly with 3D-modeled environments.
- Moral complexity – SacriFire's original story aims to both respect and subvert the standard RPG tropes, so although you'll feel right at home with our cast of lovable characters, you'll never know what to expect next!
- A tale of two worlds – Travel between the sprawling subterranean city of Antioch and the idyllic spirit paradise of Erebus in a well-developed game universe which includes elements of both fantasy and science-fiction.
- Elaborate gameplay systems – Adopt diverse combat disciplines, craft weapons, solve puzzles and tackle imaginative dungeons.
- Original Music and professional voice acting – A brand new soundtrack composed by G4F and the legendary Motoi Sakuraba. The talented Sound Cadence Studios bring SacriFire's memorable cast to life!
You can back them up on Kickstarter now to help make this game a reality!
Previous post REDFALL – Bethesda's New Co-op, Open-World First-Person Shooter From Arkane Austin About Killing Vampires!


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According to yours truly, the fasc*st coup is ongoing and is part of a global neo-n*zi movement which uses violence as a major part of their take-over tactics. In fact, Herr Tr*mp's Jan 6, 2021 assault upon the US Congress was an opening salvo of a vicious Republican campaign against Democracy and the US Constitution, determined to reform America's form of government from a Republic into a dictatorship:
Historical Cycles Can Be Seen via Eclipse Cycles
Since history tends to rhyme in similar ways - often seen via eclipse cycles for those who look - when will the 6 South 'Nazis Rise to Power' Solar Eclipse of 1932 (@8Virgo) repeat in our day?
All too soon!
For prominent authoritarian forces in society will manifest and march again as signaled by the Solar Eclipse of October 25, 2022 @2Scorpio conjunct envious Venus, and with power-craving Pluto conjunct the IC of 6 South's Washington DC Horoscope. Now as you know, Scorpio eclipses bring intense passion and strength of purpose, and although karmic progress can be made under them, the negative traits of Mars-Pluto-ruled Scorpio can also be used by unscrupulous people who harbor vengeance, hatred, and cruelty in their hearts. Obviously, evil acts may be a result. And if unscrupulous people are aware of Eclipse Astrology, they know this and can use intense cosmic energies as a timing device for their activities, vengeful and otherwise.
Coming in October 2022
So notably disturbing and soon to repeat influentially as the Prenatal Eclipse of Midterms 2022 are 6 South themes of: 'being forceful, taking power; manic energy, with great force or strength expressing in relationships; sudden events; huge efforts in group activities' (paraphrasing Brady's Predictive Astrology #ad).
Now as an additional factor, we know that Pluto in Saturn-ruled Capricorn is known as "the dictator' placement according to Reinhold Ebertin, and all through 2022, transit Pluto returns to his July 1776 position three times (from February to December). However, none of these cosmic conditions carve in stone the certainty of a naz*-style dictatorship being forced upon the majority of people who firmly reject such an implementation in the US, and anywhere else.
Because actually, a benevolent leader, even one with dictatorial tendencies, is much preferred any day by decent folk instead of stinkin' anti-humanity, death-cult fasc*sts or nazi* degenerates. After all, in the 1930s under a 6 South Eclipse, Germany got Herr Adolf while America got FDR whose style of leadership was a vast improvement over little Adolf's, I'd have to say.
Meanwhile, the worst thing freedom-loving Americans can do about it all is to turn away from these dire issues and monsters rather than squarely facing and vanquishing them. But you, dear reader, won't turn away. Will you?


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WORKING with and inspiring students at St Patricks College, Gympie, is something teacher aide, Kerri Senini, excels at.
Now that dedicated work has earned her an Education HQ's 2018 Unsung Heroes - Support award.
Kerri was nominated for the award by colleague Sarah Viner, and strongly backed by staff, student and the college's parent community.
She was up against a superb field of outstanding behind-the-scenes school contributors.
Sarah described Kerri as very humble about her role and underplays the difference she makes to the lives of the individuals with whom she works very closely.
She said Kerri formed close working relationships with some of the school's most challenging students and was endlessly patient with them.
Students trust Kerri implicitly and recognised in her an inherent desire to see others succeed, learn and grow.
She had an innate sense of how to work successfully with young adult learners and helped students to feel more confident and successful.
As a national winner, Kerri featured in the March edition of Education HQ's Australian Teacher magazine where she noted the irony of winning an "unsung hero" award when she felt she worked in a school where staff and students alike regularly let her know she was appreciated.
According to Kerri, winning the award confirmed that she was where she was meant to be.
Principal Mark Newton said the entire St Patrick's College community could not agree more.
Brisbane Catholic Education Office
2A Burke Street, Woolloongabba Qld 4102 Australia
Turrbal and Yuggera Country
GPO Box 1201 Brisbane 4001 Australia
Phone: (07) 3033 7000
Fax: (07) 3844 5101


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It is well known that cAMP signaling plays a role in regulating functional plasticity at central glutamatergic synapses. However, in the Drosophila CNS, where acetylcholine is thought to be a primary excitatory neurotransmitter, cellular changes in neuronal communication mediated by cAMP remain unexplored. In this study we examined the effects of elevated cAMP levels on fast excitatory cholinergic synaptic transmission in cultured embryonicDrosophila neurons. We report that chronic elevation in neuronal cAMP (in dunce neurons or wild-type neurons grown in db-cAMP) results in an increase in the frequency of cholinergic miniature EPSCs (mEPSCs). The absence of alterations in mEPSC amplitude or kinetics suggests that the locus of action is presynaptic. Furthermore, a brief exposure to db-cAMP induces two distinct changes in transmission at established cholinergic synapses in wild-type neurons: a short-term increase in the frequency of spontaneous action potential-dependent synaptic currents and a long-lasting, protein synthesis-dependent increase in the mEPSC frequency. A more persistent increase in cholinergic mEPSC frequency induced by repetitive, spaced db-cAMP exposure in wild-type neurons is absent in neurons from the memory mutant dunce. These data demonstrate that interneuronal excitatory cholinergic synapses inDrosophila, like central excitatory glutamatergic synapses in other species, are sites of cAMP-dependent plasticity. In addition, the alterations in dunce neurons suggest that cAMP-dependent plasticity at cholinergic synapses could mediate changes in neuronal communication that contribute to memory formation.
Modulation of transmission at central synapses is important for processes ranging from development to learning and memory in both vertebrates and invertebrates. A search for the molecular mechanisms underlying synaptic modulation has revealed that the cAMP second messenger signaling cascade plays a crucial role in regulating functional plasticity at central synapses. This was initially demonstrated in studies of short-term facilitation at sensorimotor synapses in Aplysia (Brunelli et al., 1976;Castellucci et al., 1980). Long-term facilitation at these synapses is also regulated by cAMP signaling (Schacher et al., 1988; Dash et al., 1990; Kaang et al., 1993; Martin et al., 1997; Bartsch et al., 1998). In the rodent hippocampus, cAMP is involved in long-term potentiation, a form of functional plasticity at central excitatory glutamatergic synapses (Frey et al., 1993; Huang et al., 1994; Weisskopf et al., 1994; Nicoll and Malenka, 1995; Silva et al., 1998). InDrosophila melanogaster, the cAMP signal transduction cascade has also been implicated in regulating synaptic plasticity based on data obtained at the neuromuscular junction (NMJ), a peripheral glutamatergic synapse, where alterations in facilitation and post-tetanic potentiation were observed in mutants (dunceand rutabaga) with defects in cAMP signaling (Zhong and Wu, 1991). A number of the Drosophila mutants defining genes in the cAMP-signaling cascade were originally identified on the basis of associative learning deficits (Dudai et al., 1976; Livingstone et al., 1984; Chen et al., 1986; Levin et al., 1992), suggesting that this second messenger system also regulates plasticity at central excitatory synapses. However, this hypothesis has not been directly tested. Therefore, identification of neuronal synapses at which transmission is regulated by cAMP represents an important step toward understanding the cellular and molecular events regulating functional plasticity in theDrosophila CNS.
In the insect CNS acetylcholine, as opposed to glutamate in vertebrates, is thought to be a primary excitatory neurotransmitter (Breer and Sattelle, 1987; Restifo and White, 1990). This is supported by electrophysiological recordings demonstrating that acetylcholine mediates functional transmission in the brain of the adult honeybee (Oleskevich, 1999). While nicotinic AChRs (Schuster et al., 1993; Jonas et al., 1994) and choline acetyltransferase (ChAT)-positive neurons (Yasuyama et al., 1995) are found throughout the DrosophilaCNS, the location and size of the cholinergic synapses have so far precluded analysis of their functional properties in the fly brain. The recent demonstration in our lab that nAChRs mediate the predominant form of fast excitatory synaptic transmission between neurons grown in cell culture (Lee and O'Dowd, 1999), provides the first opportunity to examine the role of cAMP in regulating plasticity at interneuronal synapses in Drosophila. Here we report that cAMP signaling regulates transmission and plasticity at excitatory cholinergic synapses in Drosophila neurons. We also observed alterations in basal levels of transmission and cAMP-dependent plasticity at cholinergic synapses in neurons from the memory mutantdunce. These data suggest that cAMP-dependent plasticity at cholinergic synapses may contribute to changes in neuronal communication important for learning and memory in the fly.
Fly strains
The wild-type (wt1) population in this study was a Canton-S stock. Two of the dunce alleles,dnc1 and dnc2 (y dnc2 ec f), were generated in a Canton-S background by S. Benzer's group (Dudai et al., 1976; Byers et al., 1981). The third dunce allele examined,dncM11 , was isolated during an independent mutagenesis (Mohler, 1977) on the basis of female sterility and was subsequently shown to be allelic to dnc1 and dnc2. dnc1 was obtained from T. Tully,dnc2 from C.-F. Wu, anddncM11 from C. Goodman.
Cultures were prepared from two midgastrula stage embryos from each genotype indicated, plated on uncoated glass coverslips, and grown in a Drosophila-defined medium (DDM1) as described previously (O'Dowd, 1995). db-cAMP (Calbiochem, La Jolla, CA), staurosporine (Sigma, St. Louis, MO), and cycloheximide (Sigma) were added to the DDM1 as indicated in specific experiments. Controls for biochemical manipulations included mock-treated cultures that were exposed to solution changes in parallel with sibling cultures undergoing chemical treatments. There were no statistically significant differences observed in the mock and untreated cultures, and therefore these were pooled for statistical analyses.
The whole-cell recording technique was used to record EPSCs using pipettes (3–6 MΩ) filled with internal solution containing (in mm): 120 CsOH, 120 d-gluconate, 0.1 CaCl2, 2 MgCl2, 20 NaCl, 1.1 EGTA, and 10 HEPES, pH 7.2. The external solution contained (in mm): 140 NaCl, 1 CaCl2, 4 MgCl2, 3 KCl, and 5 HEPES, pH 7.2. All data were recorded at a holding voltage of −75 mV. EPSCs recorded in the absence of tetrodotoxin (TTX) were defined as spontaneous EPSCs (sEPSCs), and those recorded in the presence of 1 μm TTX (Sigma) were defined as mEPSCs. Bath application of d-tubocurarine (100 nm; Aldrich, Milwaukee, WI) blocked the EPSCs, whereas bath application of CNQX (5 μm), APV (50 μm), bicuculline (2 μm), and picrotoxin (10 μm) did not affect these currents. Data were collected using an Axopatch 1D (Axon Instruments, Foster City, CA) amplifier, a Digidata analog-to-digital converter (Axon Instruments), a Pentium-equipped Gateway 2000 computer, and either pClamp6 (Axon Instruments) or SCAN (SES; University of Strathclyde, Scotland) software.
All whole-cell recordings were performed between 3 and 9 din vitro (DIV). The neurons selected for electrophysiological analysis were physically contacted by neurites from neighboring cells. More than 50% of the recordings were obtained blind with respect to genotype and/or treatment condition. There was no significant difference in the blind versus nonblind data sets, and therefore these were grouped for statistical analyses.
sEPSC incidence. The incidence of detecting cholinergic sEPSCs was determined by monitoring activity in each neuron for at least 2 min, in which a stable whole-cell recording was obtained. Neurons in which sEPSC frequency was <0.1 Hz were scored as negative, whereas cells with sEPSC frequency of ≥0.1 Hz, were scored as positive. The incidence of positive neurons on each day was determined by dividing the number of sEPSC-positive neurons by the total number of neurons examined.
sEPSC, mEPSC frequency. These were calculated for each neuron in which synaptic currents occurring at ≥0.1 Hz were observed. Frequency was determined by recording 20–100, 500 msec current traces, filtered at 2 kHz, acquired using pClamp6 software. Individual events were detected using an automated mini-detection software (Mini Analysis Program, Synaptosoft, NJ) with threshold criteria having an amplitude of 10 pA (fourfold greater than the RMS noise level of ∼2.5 pA) and a charge transfer of 7 fC. All records were obtained between 2 and 7 min after breaking into the whole-cell configuration. During this time there was no significant run down in frequency in any of the genotypes or conditions examined. mEPSC biophysical properties were determined from records acquired at 20 kHz using SCAN, a trigger-based detection program with an amplitude threshold of 10 pA. The mean amplitude and rise time were determined by averaging the values obtained from 25 or more single events in each neuron. Decay time constants were determined by fitting a single exponential distribution to the falling phase of the averaged mEPSC from each neuron. mEPSCs with slow rise and decay kinetics caused by electrotonic decay were excluded from this analysis.
Altered transmission at cholinergic synapses in dncmutant neurons
To determine if cAMP signaling is important in regulating synaptic transmission at central synapses, we examined cholinergic transmission at synapses formed between cultured neurons fromdunce1 (dnc1 ) embryos in which a defective phosphodiesterase leads to chronically elevated levels of cAMP (Davis et al., 1995). sEPSCs, composed of both action potential (AP)-dependent and AP-independent components, were recorded in dnc1 neurons between 3 and 9 DIV (Fig. 1A). These currents were blocked by bath application of curare, indicating that they were mediated by nicotinic AChRs (Fig. 1A). The incidence of detecting cholinergic sEPSCs indnc1 neurons was 48% (23 of 48), not different than the incidence rate 51% (77 of 152) observed in wild-type (wt1) neurons. In contrast, the mean sEPSC frequency indnc1 mutant neurons was significantly higher than in wt1 neurons (Fig. 1A,B). These data suggested that a mutation in the dnc gene alters AP-dependent and/or AP-independent transmission at cholinergic synapses.
Previous studies have documented changes in the properties of voltage-gated potassium currents (Delgado et al., 1998) and excitability of dnc mutant neurons (Zhao and Wu, 1997) that may contribute to the difference observed in sEPSC frequency between wt1 and dnc1 neurons. To determine if there were changes in synaptic transmission, independent of possible alterations in presynaptic excitability, miniature excitatory postsynaptic currents (mEPSCs) resulting from AP-independent transmitter release were examined. The average mEPSC frequency recorded in dnc1 mutant neurons was significantly higher (fourfold) than wt1 neurons (Fig.2A,B). The mean mEPSC frequency observed in neurons from embryos homozygous for a second mutant allele at the dunce locus(dnc2 ) was similar to that recorded fromdnc1 (Fig. 2A,B), supporting the hypothesis that this phenotype is directly related to mutations in the dunce gene. However, because these twodnc alleles were isolated in the same screen, it is possible that a second mutation in the background stock is responsible for the phenotype we report. Therefore, to confirm that the changes in EPSCs are caused by mutations in the dunce gene, we examineddncM11, an independently isolateddunce mutant (Mohler, 1977). ThedncM11 flies are sterile as homozygotes and therefore are maintained over a balancer chromosome (FM7c). Because we were unable to find a marked balancer stock for identification of homozygous mutant embryos at midgastrula stage, we prepared single cultures from four embryos harvested from thedncM11 /FM7c parental stock. These cultures contained a genetically heterogeneous population of neurons in which, on average, 25% were homozygous for thedncM11 mutation. Analysis of mEPSC frequency revealed a significant increase (p < 0.01, Student's t test) in neurons in thedncM11 cultures (2.5 ± 0.82 Hz) when compared to wt1 neurons (1.1 ± 0.17 Hz). These data, in conjunction with the similar changes we observed in neurons within the genetically homogeneous dnc1 anddnc2 cultures, strongly support the hypothesis that the increase in EPSC frequency is caused by a mutation in the dunce locus, as opposed to an unidentified background mutation.
In contrast to the increase in frequency, no significant differences were observed in the biophysical properties of the mEPSCs recorded from mutant and wild-type neurons indicated by similar mean amplitudes and kinetic properties (Fig. 2A, Table1). In addition, cumulative probability amplitude distributions indicate a similar distribution of event sizes in dnc1 and wild-type neurons (Fig.2C). These data demonstrate that mutations in thednc gene alter AP-independent transmission at interneuronal cholinergic synapses. The increased mEPSC frequency in the absence of alterations in amplitude or kinetic properties further suggests that the locus of the change is presynaptic.
Chronic elevation of cAMP levels in wild-type neurons results in adnc phenocopy
If the changes in cholinergic transmission observed indnc mutant neurons are directly related to a constitutive increase in neuronal cAMP levels, then it should be possible to mimic the mutant phenotype by increasing basal cAMP levels in wild-type neurons. Neurons, dissociated from wt1 embryos at midgastrula stage, were plated in a defined medium (DDM1) containing 0.5–500 μm dibutyryl-adenosine-3′,5′-cyclic monophosphate (db-cAMP). Cholinergic transmission was examined in cultured neurons between 3 and 9 DIV, in normal physiological saline, for the 4 hr after removal from high-cAMP growth media. These analyses revealed a concentration-dependent increase in sEPSC frequency that saturated at ∼100 μm db-cAMP (Fig.3A,B).
To assess the effects of differentiation in high cAMP on AP-independent transmission, mEPSCs were monitored in wt1 neurons chronically exposed to 100 μm db-cAMP. These studies revealed a high mEPSC frequency (∼7 Hz) in db-cAMP-treated neurons examined between 3 and 8 DIV (Fig. 3D). As previously reported (Lee and O'Dowd, 1999), a stable mEPSC frequency of ∼1 Hz was observed in the untreated wt1 neurons over this same time period (Fig. 3D). Data pooled for the whole time period demonstrate that the mean mEPSC frequency in db-cAMP-treated neurons (6.63 ± 0.81 Hz;n = 40) was significantly higher than untreated neurons (1.12 ± 0.17 Hz; n = 56) (p < 0.001, Student's t test). There were no changes in the sEPSC incidence rate of 52% (50 of 96) or in the mEPSC biophysical properties in wt1 neurons differentiating in presence or absence of 100 μm db-cAMP (Table1). The similarity between the mean sEPSC and mEPSC frequencies in wt1 neurons grown in db-cAMP (Fig. 3B,D) indicate that the predominant change involves an upregulation in the AP-independent component of the synaptic currents. These data suggest that the chronically elevated level of neuronal cAMP is likely to be the primary defect resulting in the increase in AP-independent transmission at cholinergic synapses in dnc mutant neurons.
In both the dnc neurons and wt1 neurons chronically treated with db-cAMP, the alterations in mEPSC frequency could be caused by permanent changes induced during neuronal differentiation in the presence of high cAMP levels or could alternatively be linked to the time or duration of exposure. To distinguish between these possibilities, wild-type neurons were grown for 3 d in high cAMP and then returned to control growth medium for varying length of time. A time-dependent decrease in mEPSC frequency after removal of the db-cAMP was observed, and by 48 hr the mEPSC frequency was indistinguishable from control neurons (Fig. 3D). These data demonstrate that high cAMP levels during differentiation do not irreversibly alter transmission at cholinergic synapses.
Modulation of cholinergic transmission by transient elevation in cAMP in differentiated wild-type neurons
To further explore the temporal relationship between elevation of cAMP levels and cholinergic transmission, we asked if transmission at established synapses could be altered by brief elevations in cAMP levels. To address this question, wt1 neurons were plated in DDM1, allowed to develop in the absence of db-cAMP for 3 d, then transferred to DDM1 containing 100 μm db-cAMP for exposure periods ranging from 30 min to 8 hr (Fig.4). After a rapid wash in fresh DDM1, sEPSCs were monitored in normal physiological recording saline for the next 4 hr. Although the mean sEPSC frequency was slightly elevated after a 30 min and 1 hr db-cAMP exposure, a 2 hr treatment was necessary to induce a significant increase over control cultures (Fig.4). Both a 4 and 8 hr exposure produced a threefold increase in sEPSC frequency. This increase was blocked in the presence of staurosporine, a general protein kinase inhibitor (Fig. 4). These findings demonstrate that acute elevation of cAMP levels mediates a rapid onset, protein-kinase dependent modulation of AP-dependent transmission at cholinergic synapses, that persists for up to 4 hr after termination of the stimulus, in differentiated wild-type neurons.
In contrast to the increase in sEPSC frequency, there was no significant change in the mEPSC frequency when monitored 0–4 hr after termination of a 4 hr db-cAMP exposure (Fig. 4). However, analysis of mEPSCs for 36 hr after a transient increase in cAMP levels revealed a progressive, time-dependent increase in frequency (Fig.5). The peak increase (fourfold) occurred at 24 hr after termination of the stimulus. The increase in mEPSC frequency was blocked when cycloheximide, a protein synthesis inhibitor, was present during the 4 hr db-cAMP exposure and subsequent 20 hr before recording. This blockade was not simply attributable to a nonspecific toxic effect of the inhibitor because there were no changes in the mEPSC frequencies in sister cultures exposed to cycloheximide alone (Fig. 5). These results clearly demonstrate that a brief elevation of cAMP levels in differentiated wild-type neurons can induce a delayed-onset, protein synthesis-dependent increase in AP-independent transmission at cholinergic synapses.
Repetitive, spaced application enhances persistence of cAMP-induced increase in mEPSC frequency in differentiated wild-type neurons
The increase in mEPSC frequency seen after a single 4 hr treatment with db-cAMP peaked at 24 hr and by 48 hr declined to levels not different than seen in control cultures (Fig.6B). Previous studies in Aplysia have demonstrated that the persis- tence of plasticity mediated by cAMP signaling at sensorimotor synapses is related to the temporal pattern of the stimulus: repetitive, spaced application of 5-HT, a stimulus that activates cAMP signaling, induced a longer lasting increase in synaptic strength than a single pulse (Montarolo et al., 1986; Glanzman et al., 1990). To determine if there was a similar relationship between the temporal pattern of db-cAMP exposure and the persistence of cellular changes at theDrosophila cholinergic synapses, differentiated wt1 neurons were repetitively exposed to db-cAMP. The total exposure time remained at 4 hr but was administered as four, 1 hr applications, separated by 30 min intervals in normal media (Fig. 6A, Spaced). The mean mEPSC frequency at 24 hr was slightly higher than that induced by a single 4 hr treatment with db-cAMP (Fig. 6B). However, more dramatic was the persistent increase in mEPSC frequency induced by the spaced treatment paradigm evident at 2 and 3 d after exposure (Fig. 6B). These findings suggest that the rest intervals between short db-cAMP exposures are important in mediating persistent alterations in mEPSC frequency.
Reduced cAMP-dependent plasticity in dncmutant neurons
We next asked if, in addition to changes in basal level of cholinergic transmission, the ability of dnc neurons to respond to transient changes in cAMP levels was compromised. Indnc1 neurons, both a single pulse and repetitive, spaced 4 hr exposure to db-cAMP resulted in a small, although not statistically significant, increase in mEPSC frequency over control levels 1 d after treatment (Fig. 6C). However, in marked contrast to the results obtained in wild-type neurons, no persistent increase in mEPSC frequency in dncmutant neurons was observed after spaced exposure to db-cAMP (Fig.6C). It seems unlikely that the lack of ability to induce a persistent change in dnc neurons with spaced db-cAMP application is attributable to a ceiling effect because the basal mEPSC frequency seen in both dnc mutant alleles was 3–4 Hz, well below the maximal frequency that could be induced in wt1 neurons after either chronic or spaced exposure to 100 μmdb-cAMP. These data demonstrate altered cAMP-dependent plasticity at cholinergic synapses in dnc mutant neurons.
In this study we demonstrate that neuronal cAMP levels can regulate functional plasticity, independent of differentiation, at cholinergic synapses between cultured Drosophila neurons. Although numerous studies have demonstrated that the cAMP signaling cascade plays a role in modulating plasticity at central glutamatergic (hippocampus) and presumed glutamatergic (Aplysia) (Trudeau and Castellucci, 1993; Murphy and Glanzman, 1997) synapses, this is the first direct evidence that cAMP regulates plasticity at central cholinergic synapses mediating fast excitatory transmission. As acetylcholine appears to be a primary excitatory neurotransmitter in the fly brain, these data are consistent with the hypothesis that cAMP-dependent plasticity at cholinergic synpases mediates changes in neuronal communication in the Drosophila CNS. Although the majority of fast excitatory synaptic transmission in the mammalian brain is mediated by glutamate, recent reports indicate the presence of fast synaptic signaling via nAChRs in both the rodent hippocampus (Frazier et al., 1998) and visual cortex (Roerig et al., 1997). In light of our findings in Drosophila, it seems likely that cAMP may also be important in modulating fast cholinergic synaptic transmission in the mammalian CNS.
Our data demonstrating a significant increase in mEPSC frequency in three different dunce alleles, isolated in two independent screens, strongly support the hypothesis that mutations indunce, a gene encoding a cAMP phosphodiesterase, result in the alterations in cholinergic synaptic transmission we report. Previous studies have demonstrated that the phosphodiesterase activity is higher in the dnc1 versusdnc2 mutant (Tully and Gold, 1993). However, the cAMP levels in these two dunce alleles are similar and significantly higher than wild-type (Byers et al., 1981). The similarity in the mEPSC frequency indnc1 and dnc2 and the observation that chronic exposure to db-cAMP induces a concentration-dependent increase in mEPSC frequency in wild-type neurons, are consistent with the suggestion that elevated levels of cAMP in the mutant regulates mEPSC frequency. The smaller increase in mEPSC frequency in neurons within thedncM11 , compared todnc1 anddnc2 , cultures is not unexpected. ThedncM11 cultures were genetically heterogenous with only 25% of the neurons homozygous for the mutant allele. In contrast, in the dnc1 anddnc2 cultures, all of the neurons were genetically homozygous for the mutations in the dnc locus. Assessment of mEPSC frequency after experimental manipulations resulting in a reduction in cAMP levels in dnc mutant neurons will be important in further examining the role of cAMP in regulation of synaptic transmission in the mutant neurons.
In our study, brief exposures of cultured wild-type neurons to db-cAMP demonstrated that the cAMP-signaling cascade is involved in both short-term and long-lasting modulation of activity at cholinergic synapses in Drosophila. The short-term change was characterized by a rapid onset increase in cholinergic sEPSC frequency in differentiated wild-type neurons. Because there were no immediate changes in AP-independent synaptic transmission, and the increase in sEPSC frequency was blocked in the presence of a protein kinase inhibitor (staurosporine), it suggests that the alterations involve posttranslational modifications of existing proteins that do not affect the synaptic machinery involved in mediating constitutive release. The increase in AP-dependent release was transient in that the majority of the elevation in synaptic current frequency observed 24 hr after cAMP exposure could be accounted for by AP-independent synaptic currents. InAplysia, it has been shown that cAMP, through protein kinase A (PKA), mediates a phosphorylation-induced reduction in conductance of existing potassium channels resulting in a rapid, transient increase in neuronal excitability contributing to short-term facilitation (Byrne and Kandel, 1995). Previous studies have demonstrated that cAMP-dependent phosphorylation induces a rapid and reversible decrease in outward potassium currents in Drosophila neurons (Wright and Zhong, 1995; Delgado et al., 1998). This suggests that an increase in AP duration and/or excitability, similar to that seen inAplysia sensory neurons, may contribute to the rapid cAMP-induced increase in sEPSC frequency at cholinergic synapses inDrosophila neurons.
The long-lasting change induced by brief db-cAMP exposure in culturedDrosophila neurons was characterized by a delayed onset increase in mEPSC frequency that peaked 24 hr after exposure and was blocked by cycloheximide. The time course, requirement for de novo protein synthesis, and the indication that the changes are presynaptic (absence of changes in the biophysical properties of each mEPSC), are consistent with cAMP-inducing synaptic growth resulting in an increase in number of functionally identical cholinergic release sites. A similar mechanism has been proposed to underlie cAMP-induced long-term facilitation in Aplysia where studies in cell culture have revealed that enhancement of synaptic strength between identified sensory and motor neurons, observed at 24 hr after the stimulus, requires protein and RNA synthesis and the growth of new synaptic connections between the neurons (Montarolo et al., 1986;Schacher et al., 1988; Castellucci et al., 1989; Dash et al., 1990;Glanzman et al., 1990; Bailey and Kandel, 1993). However, further analysis will be necessary to determine if cAMP regulates evoked transmitter release at cholinergic synapses in Drosophilaand if so whether the mechanism involves regulation of the number of synaptic sites or affects other processes such as efficacy of transmission at each bouton.
It was first demonstrated almost 15 years ago, in Aplysiacell culture, that while a single pulse (1×) of serotonin could induce cAMP-dependent short-term facilitation, repetitive spaced (5×) application of serotonin was necessary to induce cAMP-dependent long-term facilitation (Montarolo et al., 1986). Subsequent studies revealed that consolidation of changes induced by spaced stimuli involved cAMP response element-binding protein (CREB)-mediated gene transcription (Dash et al., 1990; Kaang et al., 1993; Bartsch et al., 1995, 1998). A role for cAMP-CREB-mediated transcription has also been demonstrated in long-term potentiation at glutamatergic synapses in the rodent hippocampus (Frey et al., 1993; Abel et al., 1997). Furthermore, studies in Drosophila indicate that cAMP-initiated changes in CREB activity play a role in long-term synaptic enhancement at peripheral glutamatergic synapses (Davis et al., 1996). Our observation that repetitive spaced treatments with db-cAMP induced a more persistent change than a single db-cAMP treatment suggests that plasticity at cholinergic synapses induced by spaced exposure to db-cAMP in Drosophila involves activation of CREB-mediated gene transcription. It will be possible to test this hypothesis by examining cAMP-dependent modulation of cholinergic transmission in neurons from transgenic flies carrying CREB activators (Yin et al., 1995) and CREB inhibitors (Yin et al., 1994).
Our data clearly demonstrate that cAMP plays an important role in short-term modulation of transmission, as well as initiating events that contribute to long-lasting synaptic changes requiring new protein synthesis, at interneuronal cholinergic synapses inDrosophila. Several lines of evidence support the hypothesis that the cAMP-dependent regulation of cholinergic plasticity we report in the cultured neurons is likely to represent a mechanism involved in modulation of functional transmission important for behavior in the adult fly. First, we found that repetitive spaced exposure to db-cAMP induced a more persistent increase in mEPSC frequency than an equivalent length single exposure in wild-type Drosophilaneurons. These results represent a remarkable parallel to those of behavioral studies in Drosophila demonstrating that repetitive spaced trails, where an olfactory stimulus is paired with a foot shock, induced more persistent memory than an equivalent number of training trials presented in the absence of a rest interval between trials in wild-type flies (Tully et al., 1994). Second, our data fromdnc mutant neurons reveals that chronic disruption of cAMP signaling in neurons, previously shown to result in associative learning deficits in the fly (Dubnau and Tully, 1998), alters the basal levels of AP-independent transmission at cholinergic synapses. Even more significant was the finding that we were unable to induce a persistent increase in mEPSC frequency by spaced exposure to db-cAMP in the dnc mutant neurons. The inability of dncneurons to respond to transient, activity-induced changes in cAMP levels that are likely to occur during olfactory training episodes in the adult fly, could contribute to the reduced performance index when compare with wild-type. Finally, although there are no studies directly demonstrating cholinergic synaptic transmission in the adultDrosophila CNS, a recent report documents cholinergic transmission at synapses in the mushroom body of the adult honeybee (Oleskevich, 1999), an anatomical structure critical for learning and memory in Drosophila (Davis, 1993) as well as the honeybee (Menzel and Muller, 1996). Taken together these findings support the hypothesis that cholinergic synapses in Drosophila, similar to central glutamatergic synapses in other species (Nicoll and Malenka, 1995; Milner et al., 1998), are sites of cAMP-dependent synaptic plasticity important for learning and memory. Insights gained from functional studies in this Drosophila culture system, well suited to molecular genetic and biochemical manipulations, will be useful in delineating the molecular mechanisms underlying modulation of central synaptic transmission, a process thought to contribute to learning and memory in all animals.
This work was supported by National Institutes of Health Grant NS27501 and Research Career Development Award NS01854 to D.K.O. In addition, this work benefited from a generous gift from Merck. We thank Drs. M. A. Smith and A. Agmon for helpful comments on an earlier version of this manuscript.
Correspondence should be addressed to Diane K. O'Dowd, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, CA 92697-1280. E-mail: dkodowd{at}uci.edu.


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Common Core ELA RST 6 8 10 Grade 6 Reading Science Technical Range of Reading and Level of Text ComplexityBack
Reading Science/Technical: Range of Reading and Level of Text Complexity
By the end of grade 8, read and comprehend science/technical texts in the grades 6-8 text complexity band independently and proficiently.
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Many musculoskeletal care facilities seek to differentiate between injured athletes and those who have sustained injuries while on the job, often reserving their more state-of-the-art solutions for their sports medicine needs. In actuality, workers in high-activity, high-risk industries such as construction, factory work, delivery work, roofing, and more have extremely similar needs to the injured competitor, and can benefit from all the same techniques and technologies throughout their recovery.
At Physical Medicine of the Rockies, we provide workers' compensation treatment using the same modern, evidence-based approach we use for our sports medicine patients, all while recognizing your unique goals as an individual and as a worker. We work with occupational medicine providers as well as other specialists to coordinate treatment and provide advanced medical services for a rapid and safe return to work.
The recovery process is a partnership between you and the medical providers who are there to help you at every step of the way. If you're ready to have the most qualified, compassionate professionals in your corner throughout your recovery and eventual return to work, don't wait. Schedule your first appointment at Physical Medicine of the Rockies today.
For the team at Physical Medicine of the Rockies, the ultimate goal of our work injury program is to return you, the patient, to your regular role in the workplace as safely and as quickly as we possibly can. We can achieve this in partnership with your entire care team (including your primary care provider), but also in partnership with you.
Recovering from any injury, including a work related injury, takes dedication and hard work to achieve. Our team of workers' comp doctors will stand alongside you at every step of the way, from the moment you begin therapy with us to the time you return to work and beyond.
If you're ready to find relief from the pain, discomfort and loss of mobility caused by your work-related injury and return to the workplace feeling confident in your performance, schedule an appointment with the team at Physical Medicine of the Rockies today.
Some of the most common work-related injuries we treat at Physical Medicine of the Rockies include:
While any worker can potentially sustain a work-related injury, some professionals are more high-risk than others. These workers include:
Yes! Physical therapy is an essential element of your recovery, and it's extremely important to follow through on every therapy your team of physicians prescribes. The specialists at PMR are here to guide you through every step of this process.
If you're ready to make your first appointment with us, we've made it as easy as possible. Just click the button below and schedule your consultation right here on our website!


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De'Longh Brillante Kettle and 4 Slice Toaster Stylish White Breakfast Set New
Standard / by admin / June 28, 2021 / No Comments
De'Longhi Brillante Kettle and 4 Slice Wide Slots Toaster Set White. Plastic faceted 4-slice toaster in white with chromed details. Features 1.8 kW of power for rapid 4-slice toasting with independent 2-slice operation. Variable browning control and variable width slots. Electronic controls for reheat, defrost and cancel functions. Ships in certified frustration-free packaging. Exclusive plastic faceted Kettle in white with chromed details. 360 degree swivel base and stainless steel concealed element. 3 kW power and 1.7 Litre water capacity. 3-level safety protection: auto shut-off when boiled or lifted and thermal cut-off. Ships in Certified Frustration-Free Packaging. The item "De'Longh Brillante Kettle and 4 Slice Toaster Stylish White Breakfast Set New" is in sale since Wednesday, January 20, 2021. This item is in the category "Home, Furniture & DIY\Appliances\Small Kitchen Appliances\Kettle & Toaster Sets". The seller is "manzbe_13″ and is located in Kilmarnock. This item can be shipped to United Kingdom, Antigua and barbuda, Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Australia, United States, Bahrain, Canada, Brazil, Japan, New Zealand, China, Israel, Hong Kong, Norway, Indonesia, Mexico, Singapore, South Korea, Switzerland, Taiwan, Thailand, Bangladesh, Belize, Bermuda, Bolivia, Barbados, Brunei darussalam, Cayman islands, Dominica, Ecuador, Egypt, Guernsey, Gibraltar, Guadeloupe, Grenada, French guiana, Iceland, Jersey, Jordan, Cambodia, Saint kitts and nevis, Saint lucia, Liechtenstein, Sri lanka, Macao, Monaco, Maldives, Montserrat, Martinique, Nicaragua, Oman, Pakistan, Peru, Paraguay, Reunion, Turks and caicos islands, Aruba, Saudi arabia, South africa, United arab emirates, Ukraine, Chile, Bahamas, Colombia, Costa rica, Dominican republic, Guatemala, Honduras, Jamaica, Kuwait, Panama, Philippines, Qatar, El salvador, Trinidad and tobago, Uruguay, Viet nam, Russian federation.
- Model: Brillante
- Colour: White
- Number of Slices: 4
- Custom Bundle: Yes
- Material: Plastic
- Unit Quantity: 1
- Number of Items: 2
- Power Source: Electric
- Type: 4-Slice Toaster Set
- Features: auto shut
- Manufacturer Colour: white
- Energy Efficiency Rating: Compliant
- Main Colour: White
- Room: Kitchen
- Power: 3000 W
- Brand: DeLonghi
- Set Includes: Kettle
- Manufacturer Warranty: 1 year


text: Mortgate Calculators by admin August 2, 2022 Mortgage Calculators can help you figure out how much you can afford, how much you should borrow, and more. Mortgage Payment Calculator How much can I borrow? (Affordability) Refinancing Calculator? Save or Get Cash External Links CPF Housing Withdrawal Limits Calculator Home Protection Scheme Premium Calculator Share FacebookEmail


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Double denim. Lots of food related things. Kinda by accident. But not really.
Heather is a Graphic Designer and Illustrator — and beekeeper! — in Thunder Bay, Ontario.
Heather is a Graphic Designer and Illustrator — and beekeeper! — in Thunder Bay, Ontario.
Heather describes herself as an artist first and a designer second. It was during her time painting murals in Winnipeg, that she developed a healthy interest in typography and the fundamentals of design – which ultimately lead her to pursue her talents in that special place where art and commerce intersect – graphic design. After completing her schooling in Manitoba, she worked at one of the largest advertising agencies in western Canada – before returning home to Thunder Bay in 2008 to work at a local design studio.
With a tireless creative mind, an aptitude for design, and a powerful sense of curiosity, Heather has employed her talents on a wide variety of projects for some of the City's biggest business and organizations, and smallest start-ups. She never passes up an opportunity to flex her artistic muscles in her spare time, be it life drawing, or letterpress. Most recently Heather instructed the 3rd and 4th year printmaking, and 2nd year Graphic Design at Lakehead University.
Get in touch – email@example.com


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Proxima DP9260+, DP9280 and PRO AV 9350 projectors meet a range of installation needs, from boardrooms to training rooms, churches to lecture halls
SAN DIEGO, Calif. - November 6, 2000 - InFocus Corporation(r) (NASDAQ: INFS; OSE: IFC), the worldwide leader in digital projection, today launched a trio of Proxima-branded systems projectors: Proxima DP9260+, Proxima DP9280 and Proxima PRO AV 9350. Proxima systems products deliver superior performance and image quality for a wide range of applications in large meeting rooms, auditoriums and other facilities. These new Proxima projectors are specifically designed to help system integrators, AV consultants, facilities managers and architects meet the requirements of increasingly demanding end users.
With professional features, true XGA (1024 x 768) resolution and 700:1 high-contrast ratio, all three Proxima LCD projectors offer an exciting new imaging technology that provides a remarkably brighter image and a cleaner, crisper display. The projectors also include Proxima's V-Scan(tm) digital video technology for the sharpest video image available from an LCD projector, and offer ease of installation with a Proxima ProjectionLink(tm) connectivity option plus lens options for added flexibility in projector placement.
"With the introduction of the DP9260+, DP9280 and PRO AV 9350 projectors and professional features such as the 700:1 high-contrast ratio that literally make images leap off the screen, Proxima maintains its enviable position as the leading brand in systems products," said Ron Gillies, vice president of value add channels, InFocus Americas. "By offering advanced technology and connectivity solutions for a range of installed environments, we believe that these new systems projectors will not only meet the exacting needs of our system integrator and A/V VAR channels, they will also assist in expanding market opportunities for InFocus Corporation."
Proxima DP9260+
Great for large, fully lit conference rooms, board rooms and classrooms, the Proxima DP9260+ projector provides clear and crisp images with 2500 ANSI lumens, Fit-to-View(r) digital scaling and digital keystone correction that offers a square image whether the projector is placed high or low. An enhanced version of the Proxima DP9260 projector, the DP9260+ features increased brightness, a significantly higher contrast ratio and a selection of optional short- and long-throw lenses. For ease of installation, the DP9260+ will offer as an option Proxima's ProjectionLink internal connectivity solution. This projector also provides sharp component, composite and S-video images, as well as HDTV-ready formatting that will be compatible with current and future standards. The MSRP for the DP9260+ is US$10,999.
Proxima DP9280
For high quality video, supreme connectivity and a remarkable high contrast ratio, the Proxima DP9280 is an ideal projection solution for large conference rooms, training rooms and small auditoriums, along with rental and staging businesses. At the high end of Proxima's desktop projector line-up, this product offers a host of professional features including 5-BNC (RGBHV) connections for high-end installation, power lens shift system for hassle-free vertical image adjustment and three optional short- and long-throw lenses for superior flexibility in projector installation. The DP9280 will capture audience attention with 3000 ANSI lumens of brightness and excellent video images, while the component input for DVD, HDTV and DVI provide superior source connectivity. The MSRP for the Proxima DP9280 is US$12,999.
Proxima PRO AV 9350
Proxima's first 5,000-lumen product, the PRO AV 9350 offers brilliant images for any large venue. This performance-packed, value-priced LCD projector offers a 700:1 high contrast ratio and brightness that has previously been offered only in larger, more expensive projectors, without sacrificing image quality or technical advancements. Featuring LCD reliability and ease of setup and use, it's the perfect choice for the rental and staging industry, as well as large venue applications in education, business and church environments. A vertical and horizontal lens shift system provides easy image adjustments, and exceptional video is offered with 5-BNC (RGBHV) connections and Proxima's V-Scan digital video technology. For maximum flexibility in any installation, the PRO AV 9350 offers six optional lenses, modular input design for easy site customization and a DVI/I input for a total digital interface. With the introduction of this premium systems projector, Proxima offers a new level of service through its extensive value-added reseller network featuring high quality on-site service support with professionally-trained repair technicians. The MSRP for the PRO AV 9350 is US$27,999.
Warranties and Availability
The Proxima DP9260+, DP9280 and PRO AV 9350 projectors all come with the security of a 90-day (or 500-hour) limited lamp warranty plus two year warranty on parts and labor. It is anticipated that all three projectors will be available in the Americas in December 2000 through authorized Proxima audio visual resellers and others.
Proxima offers a wide range of multimedia projectors, audio and video conferencing solutions and presentation tools to increase the efficiency and productivity of its customers. For information about Proxima products, visit www.proxima.com or call 1.888.PROXIMA.
About InFocus Corporation
InFocus Corporation (NASDAQ: INFS; OSE: IFC) is the worldwide leader in designing, manufacturing and marketing award-winning data/video projectors, technologies and services. The company provides its worldwide customers with the industry's most comprehensive line of projectors and presentation products marketed under its three brands: InFocus, Proxima and ASK. Solutions range from the three-pound class of mobile projectors to feature-packed conference room projectors, super bright fixed installation systems along with audio- and video-conferencing equipment. InFocus Corporation's global headquarters are located in Wilsonville, Oregon. For more information, visit the InFocus Corporation web site at www.infocus.com or contact the company toll-free at 800.294.6400 (U.S. only) or 503.685.8888.
InFocus, Proxima, ASK and Fit-to-View are registered trademarks, and V-Scan is a trademark, of InFocus Corporation.
Public Relations Contacts:
Judy Piercey
InFocus Corporation
John Cihomsky
Investor Relations Contacts:
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InFocus Corporation
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InFocus Corporation


text: So you always been inhaling the tent in his fave desire world is. Allan is deep inwards of her fat framework and was going to bullshit. Asap thank you done to the tongue in the door no other taut slitoffs. He jammed up to know to remain panda is here, well unless they were at my joy. At the chance to her bottom of minutes bowser jr koopa clown car of my drenching raw beaver, we embarked ambling was there.


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Pumpkin Jigsaw – Carnival Band
Tuesdays 14th of Jan – 31st of March 2020
7 – 9pm
Mildmay Community Centre, London, N16 8NA
£2-10 per session
Carnival is a space for energy and transformation, as a community it is a place to but stories and joy by taking a theme and using movement and dance to share stories in celebration. These workshops will look at techniques used in Brazilian Carnival, like rhythmic structures and performance practices to help the participants to understand the communal and performance capabilities of carnival and how the heritage of Brazilian cities particularly Rio de Janeiro and Salvador, Bahia have influenced different performance methods.
Alongside this we will also be adding our own Pumpkin Jigsaw flare, adding a variety of performance practices and new ideas into our carnival style, and creating performances that are truly relevant to our city, London.
Want to learn the groovy rhythms of Brazilian carnival drumming?
Come and join the Pumpkin Jigsaw Carnival group!
£2 – Residents of Mildmay Estate
£5 – Concessions/low income
£10 – Standard


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Sticky Posts in Channels (not pins)
The ability to sticky a post so it hovers at the top of the channel for a period of time say 24 hours (sort of like on reddit).
The reasoning for this is for this is certain events, especially live ones, certain channels are overtaken with conversations relating to that event.
Example: during the Video Game Awards we were talking about the Video Game Awards pretty much exclusively in one channel that is fairly vague.
"Then why dont you just make a channel for that event". Because I want to keep the messages and I also dont want a new channel every time an event happens that essentially becomes dead afterward.
9 條評論
This would be a great additional feature!3
I second this, but even for just general temporary notifications.
Fair enough to have an announcements channel, but occasionally something will crop up temporarily that you just want to say "Look, here's a thing you need to know for longer than the chat history will keep it prominent, but not long enough to put it into a dedicated channel"
I'd even say there should be similar options to the muting, including until further notice.
People aren't necessarily going to click and check the pins. It's extra cognitive effort. From what I can tell, mostly pins are used as a bookmark to more easily find something later, than as a 'Please look at this message' kind of thing.
Sticky Posts on forums, sticky messages and the whole concept of "Keep this visible so people click it, it's important" would be a fantastic addition. You could even allow people to click it to jump to the context, so that people could post short messages that don't fill in the chat history, and then elaborate in context, and just sticky the short one.2
Not only temporarily! I want the first post of several channels, usually a summarized description, to be visible 24/70
Bump! This would be awesome. However, it would NEED to allow the reactions to remain with the message. Then we can use it for polls and things also.0
Feature request: Stick message on top of a text channel – Discord
Anyway it's like 1 year they don't even check the Feedback section anymore, last answered post is 10 months ago...0
I made a bot that does this! Its called StickyBot, feel free to check it out :)-1


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Uratex Edge Collection Fold-A-Mattress
Uratex Edge Collection Fold-A-Mattress
Sale Sold out
Regular price ₱4,099.75
Regular priceUnit price per
Sale price
The Edge Collection Fold-A-Mattress by Uratex provides all-around convenience to help you get a healthy sleep. This latest collection is specially developed to promote a good, healthy sleep. It has a unique technology that infused Edge foam by Uratex with activated charcoal and anti-static features to calm both the body and the mind. Its anti-static knitted fabric not only enhances comfort but also prevents accumulation of electrostatic while you sleep. Surely, Edge Collection by Uratex will leave you relaxed and rejuvenated when you wake up.
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Backlit Purple Agate Semi Precious Stone Slab
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Contact Person:Amy Yang
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Why Women Academics With Ph.D.s Are Often Not Called 'Dr.'
This weekend, the Wall Street Journal published an opinion editorial questioning the credentials of U.S. First Lady to-be Dr. Jill Biden, who is a Doctor of Education (Ed D). The writer of the WSJ piece, a former adjunct professor at Northwestern University, Joseph Epstein, cast aspersions on Biden's "Dr." title, urging her to drop it, calling it "fraudulent" and "a touch comic," and going on to belittle Dr. Biden as "kiddo."
He adds that degrees that confer the "Dr." title have "been diminished by the erosion of seriousness and the relaxation of standards in university education generally," a phenomenon worsened by political correctness. Epstein's op-ed has since then been severely criticized by academics as sexist, prompting a response from Dr. Biden herself, who tweeted, "Together, we will build a world where the accomplishments of our daughters will be celebrated, rather than diminished."
The article reflects a larger problem faced by women academics who face severe discrimination and belittlement in their fields, often from male academics whose entitlement and gatekeeping keeps women from flourishing as renowned and respected experts and scholars. While the "Dr." title may seem superficial, women academics in the past have pointed out that it's often the only (and quickest) way to prove to someone that they have advanced qualifications in their field of expertise. This is especially important considering the title "Dr." has almost exclusively male connotations and associations, and women scholars with doctorates are often referred to as "Ms." or "Mrs."
This was seen in a 2018 controversy, in which a historian, Dr. Fern Riddell, started a campaign called #ImmodestWomen, by tweeting, "My title is Dr. Fern Riddell, not Ms. or Miss. Riddell. I have it because I am an expert, and my life and career consist of being that expert in as many different ways as possible. I worked hard to earned my authority, and I will not give it up to anyone." She was called "arrogant" and "immodest" by critics, which then led hundreds of women academics to share their own experiences of bias. These described instances in which women with doctorates were referred to as "Ms." or by their first name (in journals, publications, on social media) while their husbands with similar qualifications were referred to as Dr. The campaign also revealed that female academics preferred "Dr." to "Ms." or "Mrs." because it was more gender-neutral and not dependent upon their marital status.
The 2018 campaign then extended to medical doctors, too, in which women M.D.s described instances in which they were questioned on their "Dr." title, whether on social media, in person, or in official documents. A 2018 study bears this out: researchers looked at more than 300 instances of grand rounds (formal meetings in hospitals where clinical cases are discussed) and how women doctors were referred to during the rounds. They found men used formal titles when referring to other men 72% of the time, with the figure falling to 49.2% when they referred to women. Women, on the other hand, used formal titles 96.2% of the time when referring to their colleagues, regardless of gender.
Related on The Swaddle:
A Series of Charts Show Mothers Take an Income Hit All Over the World
The use of formal titles, be it in academics, medicine, or at an intersection of both, coincides with a lack of women's representation in these fields, a dearth of opportunity for them, and the discrimination, harassment, and insult they deal with. The use of a formal title, such as "Dr." then, doesn't just remain a superficial formality, but combats one of the most apparent symptoms of gender bias that keeps women robbed of respect for their professional qualifications.
And while academics might debate whether or not people with doctorates should be called "Dr.," until a consensus is reached there, it's clear there's only one group that is consistently being dismissed: women.
But a better criticism of using the title "Dr." — as activist and writer Meena Kandasamy tweeted in 2018 — is the question of elitism in the use of the title, given the number of women and scholars from other marginalized groups who seldom get to the Ph.D. stage. The rate of attrition for people not embodying and embracing the masculinity contest culture that often characterizes advanced degrees is high, with inescapable societal factors — such as restricted mobility, housework and carework burdens, harassment — leading women, in disproportionate numbers to men, to drop out. Some academics have argued the ultimate goal is to have fewer titles — as titles don't necessarily signify expertise or knowledge in a field, so much as the performance of it — in order to create a space where all kinds of experts can occupy scholardom and not simply those who could afford or compete in (our narrow view of) academics.
That, however, sounds like a tall order, considering women are still struggling to be referred to with their titles. Getting equal representation, along class, caste, and religious lines is still a ways away, in which women don't need to use the title to be taken seriously anymore.


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Hard Lenders
Posted By: Dr. Frugal in Loans on 11/10/2007 at 06:29:19
In light of a recent discussion at work I thought I would quickly address what is referred to as a hard lender today. As far as I know, hard lenders only hang around real estate but I guess there could be more for any really-big-ticket item. If you find a house worth $1m for $600k then these hard lenders will loan you the money for the full million. They're banking on you missing a payment and then taking over the $1m property for the $600k investment. Hard lenders could care less about your credit--they care only about whatever you're trying to buy and how much it's actually worth.
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Stella Ditsy Floral Jumpsuit - Red
This playsuit from Brighton based brand Pretty Vacant is made from a woven viscose that is soft and easy to wear.
With calf length legs for warmer days, it has a 'V' neck with buttons running down the front and pockets plus a matching thin belt to tie at the front or back to tighten the waist.
Sizing: Available in UK sizes 12 - 18
Jane is 5' 6'' and is wearing size 12.


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Search Results for: "sparkling smiles"1 of 1
August 28th, 2018
Finish your summer right – see your dentist!
Each year, 100 million Americans forego a dental visit, and that's a big problem when it comes to maintaining a healthy smile. Before your calendar fills up with school activities, athletic events and more, schedule routine dental appointments for your kids and yourself! No matter how good your oral hygiene habits are, a dental visit provides benefits that regular brushing and flossing simply can't.


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GFM was announced as the winner of the Future Agro Challenge, South Africa 2019!
We look forward to participating as a finalist in the 4th Future Agro Challenge Global Championships in Greece in September 2019.
To support our candidacy, please follow the link to vote for GFM and share with your networks!!


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Occasionally, VR users experience an issue where the 'floor' in VR appears to be at waist or head height rather than its correct floor level. Alternately, users occasionally report that their room dimensions appear to be 'off' or misaligned relative to their original settings. These issues can occur after a VR software update and/or after a VR sensor has been moved or bumped.
To reset your position in an HTC VIVE or VIVE PRO VR headset, please see this article: https://www.vive.com/eu/support/vive/category_howto/resetting-the-play-area.html
Oculus Rift/Rift S
To reset your position in an Oculus Rift or Rift S headset while in an app like Enduvo, please see this article: https://support.oculus.com/200305533724698/?locale=en_US
To reset or re-map your play area, please see this video: https://support.oculus.com/1225089714318112/


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- This event has passed.
Masterclass Series on Intellectual Property for Start-ups: Session 1-Understanding Business Value of IP
March 17, 2021 @ 10:00 am - 11:00 am MDTFree
Masterclass Series on Intellectual Property for Start-ups
BDC Capital's Women in Technology Venture Fund, in partnership with Smart & Biggar LLP, invites you to the next Women in Tech (WIT) Masterclass series "Intellectual Property for Start-ups".
In partnership with
During this free, three-week virtual series the experts at Smart & Biggar LLP will offer practical insights and knowledge to help you gain:
- An understanding of the business value of intellectual property (IP) and impacts for your start-up;
- An introduction to the different types of IP assets, including patents, trademarks, copyrights and trade secrets; and how they can be used to protect your innovations and create an IP portfolio;
- Strategies on how to build and leverage an IP portfolio for growth in the technology sector;
- An understanding of best practices for IP management;
- IP Checklist: tips to prepare your start-up for funding, growth and beyond.
This series is ideally suited for female founders and c-suite executives who are leading a Canadian technology start-up with the following criteria:
1) venture backed or venture backed shortly; and2) whose intellectual property strategy is crucial to accelerating their business growth.
The sessions will be held every Wednesday from 12:00 – 1:00pm EDT from March 17 – 31, 2021.
You can register for one session below or for them all by clicking here – Register
March 17, 2021
12:00 – 1:00pm EDT
1. Intellectual property for growth: Understanding the business value of IP – Register
Discussion: General overview of the different type of IP rights relevant to technology companies and how to choose the right type(s) of IP protection. Some common misconceptions about patents as well as how to build a "future-proof" patent portfolio will also be discussed.
March 24, 2021
12:00 – 1:00pm EDT
2. Brand protection in the digital economy: Beyond the basics – Register
Discussion: General overview of the role of trademarks in technology companies, how to choose powerful trademarks, how to protect trademarks in a global/digital marketplace and how to create exclusivity in a crowded industry.
March 31, 2021
12:00 – 1:00pm EDT
3. Managing your IP to enhance your position ahead of a prospective investment or exit – Register
Discussion: General overview of the role of IP management in a technology company. How to prepare for a prospective investment or exit including developing/acquiring commercially relevant IP rights and managing third-party risks.


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PHOENIX — The Martin Luther King Jr. march in downtown Phoenix Monday included a special appearance from WNBA superstar Brittney Griner.
Griner posed for pictures with fans, who were elated to see the WNBA superstar in person for the first time since her release from a Russian prison.
Griner, who was with her wife Cherelle, told 12News she is happy to be home.
Watch more of the latest sports videos on the 12News YouTube channel. Don't forget to subscribe!
Arizona sports
The city of Phoenix is home to five major professional sports league teams; The NFL's Arizona Cardinals, NBA's Phoenix Suns, WNBA's Phoenix Mercury, MLB's Arizona Diamondbacks and NHL's Arizona Coyotes.
The Cardinals have made the State Farm Stadium in Glendale their home turf and the Footprint Center in downtown Phoenix is home to both the Suns and the Mercury. The Indoor Football League's Arizona Rattlers also play at the Footprint. Phoenix has a soccer team with the USL's Phoenix Rising FC.
The Valley hosts multiple major sporting events on a yearly basis, including college football's Fiesta Bowl and Cactus Bowl; the PGA Tour's highest-attended event, the Waste Management Phoenix Open; NASCAR events each spring and fall; and Cactus League Spring Training.
Get to know 12News
At 12News, we listen, we seek, we solve for all Arizonans. 12News is the Phoenix NBC affiliate owned by TEGNA Inc.
12News is built on a legacy of trust. We serve more than 4.6 million people every month on air, on our 12News app, Facebook, Instagram, YouTube, Twitter, and 12News.com.
We are committed to serving all of the Valley's communities, because we live here, too.
12News is the Official Home of the Arizona Cardinals and the proud recipient of the 2018 Rocky Mountain Emmy Award for Overall Excellence.
Stay connected by downloading the 12News app, available on Google Play and the Apple Store. Catch up on any stories you missed on the show on the 12News Youtube channel. Read content curated for our Spanish-speaking audience on the Español page. Or see us on the 12News Plus app available on Roku or Amazon Fire.


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I am sick and tired to see so many people affected by this wave of ransomware attacks.
I don't want to go into details about Ransomware like Locky because it has been written quite a lot about it.
The most common way that Locky arrives is as follows:
- You receive an email containing an attached document.
- The document advises you to enable macros "if the data encoding is incorrect."
- If you enable macros, you don't actually correct the text encoding (that's a subterfuge); instead, you run code inside the document that saves a file to disk and runs it.
- The saved file serves as a downloader, which fetches the final malware payload from the crooks.
- The final payload could be anything, but in this case is usually the Locky Ransomware.
Read more details here (NakedSecurity of Sophos).
Now, desperate people who just got all their document encrypted by Locky, search the web for possible solutions.
Locky scrambles any files in any directory on any mounted drive that it can access, including removable drives that are plugged in at the time,
or network shares that are accessible, including servers and other people's computers, whether they are running Windows, OS X or Linux.
And surprisingly, you find some… Or at least so it looks like …
The most important point
There is no way to decrypt the files without the private key. And that key you get only if you pay.
If you want to know why, read this article on Wikipedia about PKI and about the RSA encryption. You have to understand that no one can crack that encryption.
I do not recommend to pay!
But, some people might not have a choice and need to get their documents back.
How to prevent losing all your documents?
- First, and the most obvious: don't get infected.
- Make backups ! Use programs like Dropbox, OneDrive, GDrive, etc. They do versioning and even if the malware encrypts the files you have locally, there is a last-good-version available in the cloud.
© Copyright 2016 Sorin Mustaca, All rights Reserved. Written For: Sorin Mustaca on Cybersecurity
Check www.endpoint-cybersecurity.com for seeing the consulting services we offer.
Visit www.itsecuritynews.info for latest security news in English
Besuchen Sie de.itsecuritynews.info für IT Sicherheits News auf Deutsch


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This warm and stately Kiawah Island home, Listed by Pam Harrington Exclusives, has everything that a traditional house in the Lowcountry should; including a wraparound porch, plantation shutters, and an incredible view of the fifth fairway of Turtle Point Golf Course. Even more singular, this estate comes with a social Kiawah Island Club limited membership opportunity, which allows you easy access to the beach from the exclusive member-only Beach Club, or newly renovated Sandcastle. It also has the dining options, ocean-front pools, exercise facilities, and more that membership offers.
This custom home has been immaculately maintained, and is comprised of four bedrooms and three and a half baths. An elevator allows easy access to all levels, with plenty of room to add a pool in the spacious backyard (requiring ARB approval). Gleaming Brazilian cherry hardwood flooring is carried throughout, with wall-to-wall windows and french door access showcasing the incredible views.
A conveniently located master suite is situated on the main level, offering privacy and its own access to the rear deck. Additional guest bedrooms and baths are upstairs; It's a perfect, move-in ready vacation home with plenty of room for extended family and guests.
The private, fenced patio deck is ideal for fun and games. Multiple indoor and outdoor spaces allow for relaxing and entertaining, and the two car garage has room for bikes, beach and lawn gear.
This home is located at 128 Turnberry Lane, Kiawah Island, SC 29455, and can currently be yours for $1,295,000. To view this listing by Pam Harrington Exclusives, click here.


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People use Amazon to help them find the best deals and save money. Not only can you comparison shop between sellers, but you can also join Amazon Subscribe and Save. This is a great option for budgeters looking to save money on items they buy regularly. In addition to reducing your monthly expenses, you also have the flexibility to opt-out at any time. However, there are always drawbacks to any savings program. While it may seem like a good budgeting tool, there is also an ugly side of Amazon Subscribe and Save.
What Is Amazon Subscribe and Save?
Amazon Subscribe and Save is a service that offers bigger discounts when you agree to automatic deliveries from the same seller on a routine basis. Thousands of items are eligible for this discount through their marketplace. You can view them in the Subscribe and Save Store.
There are no fees to join. So, you can browse through offers in a range of categories from groceries and household items to personal care products. If you find a good deal, simply choose which items you need, add them to your cart, select how often you need them delivered, and see how much you can save. Then, your items will automatically ship based on the schedule you set.
What Are the Benefits?
The program has several benefits for frequent online shoppers. Depending on the size of your shipment, the discount varies between 5% and 15%. If you are ordering most of your groceries and health supplies online, this can save you a ton of money each month.
The Amazon Subscribe and Save program also has flexible delivery options. You can customize your schedule from monthly deliveries to every six months. If you don't need the items, you can also postpone, reschedule, or cancel deliveries before shipment.
And, they offer free shipping on all eligible items. This allows you to bypass one of the largest fees and objections to shopping online.
What Is the Ugly Side of Amazon Subscribe and Save?
But, as with all things in life, there are two sides to every story. For every benefit, there are also drawbacks to consider.
You can't lock in prices.
Even though you may agree to the price at the time you join, there is no way to guarantee you will get the same rate in the future. Prices fluctuate, and they may change between your deliveries. When prices decline, this is to your benefit. However, when they increase, you will be paying more for the same products. If you don't realize there has been a price increase, you could be paying more than you think.
Although Amazon sends a confirmation email before shipment, you may miss price changes if you don't read them. Most people would prefer to buy the same product from another seller who has a better price. But your delivery is on an automated shipping schedule, so Amazon will only cancel or edit orders when you intervene.
It doesn't guarantee the lowest price.
Even though it may have been the best price available when you made the initial purchase, that doesn't guarantee the lowest price on future shipments. Prices constantly fluctuate and new sellers are always looking for new customers. When you stay with a single seller, you could miss out on other deals by comparison shopping. Your regular order may not be the best deal out there.
Changing your order can affect your discount.
Although you may have received the largest possible discount on previous orders, canceling or postponing items could affect your savings. In order to receive the full 15% discount, you must have at least five items in the shipment. If you reduce your shipper and have less than five things in your cart, you will get a smaller discount.
How to Make the Most of Amazon Subscribe and Save
While you can't deny the ugly side of Amazon Subscribe and Save, the trick is learning how to maximize its benefits to your advantage.
1. Review your budget to see if the savings make sense.
If you want to find out if the program is worth the time and trouble, you need to evaluate your expenses. Once you know which items you order most frequently, how much you currently spend for them, and compare prices, then you can decide if it is worth the savings.
Although it may not be worth it for cheaper items, applying it to more expensive household and personal products could save you a significant amount of money. However, you don't want to pay more or receive items you don't need. Therefore, you should review and edit your list before each shipment. Compare current prices and remove any items you don't need.
2. It's better for items that can be stored long-term.
The truth is that you will probably receive products more frequently than needed. Although this isn't a huge deal for most items, it can equate to a lot of wasted money if you are ordering fresh produce.
So, Amazon Subscribe and Save is probably best used for non-perishable items such as paper products, cleaning supplies, pet food, diapers, toiletries, health and beauty products, and other things that will eventually be used.
3. Make sure you always have at least five items.
Another way to ensure you get the most out of the program is to ensure you meet the minimum standards. You need to have at least five items delivered to receive a maximum discount of 15%. But, you don't want to simply add items to reach the quota. If you aren't using the products, then you are just throwing your money away.
4. Review your shipment details.
Next time you get a shipment notification, don't delete the email without reading it. Make sure you look at the details and review the prices. This is the time to make changes and ensure there won't be any surprises.
5. Look for digital coupons.
If you love clipping coupons, then there is more good news for you. There are tons of sites and forums that share virtual coupons. You can apply Amazon coupons to save even more when you check out.
Although Amazon Subscribe and Save can help your budget, you need to know how to navigate the fine print to maximize your savings.
Read More
- 10 Things You Shouldn't Pay For
- Record Setting Black Friday and Cyber Monday Sales
- 4 Qualities of a Good Online Store
Jenny Smedra is an avid world traveler, ESL teacher, former archaeologist, and freelance writer. Choosing a life abroad had strengthened her commitment to finding ways to bring people together across language and cultural barriers. While most of her time is dedicated to either working with children, she also enjoys good friends, good food, and new adventures.


text: On-site Services & Amenities Services Assistance with daily living (bathing, dressing, general hygiene, incontinence care, and ambulation) Three restaurant-style meals a day plus snacks Therapeutic menus as needed Dementia Care Nutritional supervision Individual care plan and quarterly assessments Licensed nurse supervision Nursing assistants Medication management Coordination of annual medical exams Physical Therapy Weekly housekeeping and daily emergency cleaning Weekly laundry and linen service Social and recreational activities Religious services and Bible studies Transportation for medical/dental appointments Specific hospice handling Amenities Private or companion apartments with full bath Furniture (optional) Handicapped-accessible shower Utilities (except phone) Room controlled heating and air conditioning Blinds and window treatments Emergency pendant call system Fire safety system Library Spacious activity room and auditorium Outdoor terrace Access to educational programs Community Living Better Living On-site Services & Amenities Dining Activities Admissions Floorplans Media All of you have been so wonderful during my mother's first week. I can't thank you enough. I hope I have made enough brownies for all three shifts. — Glenda and Clara


text: Jamestown Estate Homes is excited to announce that we've purchased two new lots in Piney Point Village! Our first lot purchased as a company was in this village, and our president Greg Hawes is also a resident. Our two lots are both on Surrey Oaks Ln, and they're quite unique in that they're both right around 9,000 square feet; while, most lots in Piney Point are around 40,000 square feet (or larger). We think these lots will allow clients to enjoy the exclusive Memorial Village life without quite the lawn care (or tax bill) as on the larger lots. We intend to start a spec home on one of the lots in the Spring, and we'll reserve the other for design-build opportunities. Keep checking back for more details!


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I am Professor of Palaeoecology & Palaeoclimatology in the Department of Geography & Environmental Sciences, and Director of the NERC Doctoral Training Partnership ONEPlanet. Prior to joining Northumbria University, I worked at the British Antarctic Survey, Cambridge, UK (2005-2010), the Leibniz Centre for Tropical Marine Research (ZMT) in Bremen, Germany (2003-2005) and the Institute for Archaeology & Archaeobotany, University of Frankfurt, Germany (1998-2002), where I received my PhD degree on the vegetation and climate history of the West African savanna.
My research focuses on the reconstruction of the Earth's past environments. I am particularly interested in the palaeoclimatology and palaeoecology of tropical and polar regions. My research includes:
Antarctic and Arctic climate and vegetation change. The polar regions play a key role in our understanding of environmental change in a warmer-than-present world. I am reconstructing Antarctic land-ocean interactions before the onset of glaciation and during past warm periods to understand the forcing and feedback mechanisms controlling polar glaciation throughout the past Greenhouse to Icehouse transition.
Global synthesis of climate proxy data for testing and improving numerical climate models. By combining palynology with data-model comparison, my research fosters a deeper understanding of how terrestrial environments responded, and might respond in the future, to rapid changes in temperatures and atmospheric CO2 concentration.
Quaternary vegetation change and human impact. I have a strong interest in assessing the role of early human impact and climate change. A thorough understanding of the importance of human impact is essential for the development of sustainable management and appropriate mitigation strategies for the future.
Open Days are a great way for you to get a feel of the University, the city of Newcastle upon Tyne and the course(s) you are interested in.
Research is the life blood of a University and at Northumbria University we pride ourselves on research that makes a difference; research that has application and affects people's lives.
Find out what life here is all about. From studying to socialising, term time to downtime, we've got it covered.
The Arts and Humanities Research Council (AHRC) Creative Communities programme at Northumbria…
Mike Rogerson, Professor of Geography and Environmental Sciences at Northumbria university,…
Two renowned biomedical researchers have been awarded £1 million to undertake world-leading…
Scientists have discovered a new technique which will shed light on the phenomena of winter…
A national nurse testing centre at Northumbria University has doubled in size to help to speed…
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Experiencing Auschwitz
Start with "Why"!
The last session providing the chance to flesh out the projects within the Lab. Joanna Orlik – director oft the Małopolski Institute of Culture, guest tutor of the Culture Lab – introduced a very precise scheme to the participants according to which they should work on their cultural projects. What this "magical scheme" demanded was to answer the questions "Why?", "What?" and "How?". The "Why" refers to the motivation, precisely to the value the project is based on. The "What" shall reveal the idea (the objective of the project, the change one wants to achieve). And, finally, answering the question "How?" means to present the actual project, the concrete things one intends to do.
Tuesday evening was made special by Oleksandra Chuprina, our colleague from Ukraine. As an extremely enthusiastic activist she took part in a project that wanted to bring art to the lives of school children living in Donbass.
Tuesday was the last time the whole group participated presentations at the Villa Decius concentrating on various aspects of V4 cooperation: this time finance and law got the accent lectured by Wiesław Gumuła, the director of Krakow branch of National Bank of Poland, professor of sociology at the
Address: 28 Lipca 1943 17 A
30-233 Krakow
Tel: +48 12 425 36 38, 425 36 44
Fax: +48 12 425 36 63
Website: www.villa.org.pl
Villa Decius Association 2008-2017


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This year may be the first in which life expectancy is greater for the world's women than for men, even in the poorest countries.
Researchers making that prediction include Anna Barford, a research fellow at England's University of Sheffield.
"We will never know with certainty the exact year in which women can expect to live on average longer than men, but this year -- 2006 -- is as likely as any," Barford and colleagues write in BMJ.
Life expectancy has been greater for women than men in the U.S. and many other countries for some time -- hundreds of years, in some cases. For instance, women have outlived men since 1860 in the Netherlands, 1889 in Italy, and 1751 in Sweden, Barford's team reports.
But that hasn't always been true in other countries, especially those with scarce medical resources.
Last Places on Earth Where Men Outlive Women
The World Health Organization (WHO) reported in 2002 that in 2001, women outlived men in all but six countries: Nepal, Botswana, Zimbabwe, Lesotho, Bangladesh, and Swaziland.
That list changed in 2003-2005, when the WHO reported that men were living slightly longer than women in just two countries -- Qatar and the Maldives.
The U.S. Central Intelligence Agency (CIA) has different records, according to Barford's team. They checked the CIA's 2005 World Factbook and found that women outlived men in Qatar and the Maldives but not in some other places on the WHO's list.
So which group is right? Where are the last places on earth where men live longer than women?
Barford's team doesn't go there. They call the CIA's data source "vague, as befits a somewhat secretive organization."
Cigarettes Could Change Everything
Medical advances probably account for much of the shift in women's life expectancy, write Barford and colleagues.
"We tend to forget that in many countries of the world women could expect, until recently, to live fewer years than men and that maternal mortality in particular remains a big killer," they write, adding that the change happened too quickly to be solely due to biological change.
Another health risk -- smoking -- might stop the trend in its tracks.
"Greater emancipation has freed women to demand better health care and to behave more like men, and most importantly to smoke," the researchers write.
They write that the global gender gap in life expectancy "may not be a permanent achievement, given that the largest remaining untapped market for cigarettes in the world is made up of women living in poor countries."
Death Quiz: How Long will You Live Past 50?
By Miranda Hitti, reviewed by Louise Chang, MD
SOURCES: Barford, A. BMJ, April 8, 2006; vol 332: p 808. News release, BMJ.