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The Rolls Royce Service Center Of Choice In Dubai
Every single car manufactured by Rolls Royce speaks volumes about the brand's dedication towards delivering utmost luxury, unmatched craftsmanship and unbeatable automotive comfort. The vehicle has never failed at drawing envy for its superior comfort, beauty and performance. If you truly want your vehicle to keep delivering the performance it is known for, then it is highly recommended for you to have it regularly checked out and maintained by a trusted provider of Rolls Royce service in Dubai – and if that's what you are interested in, then you can trust the team at German Auto Care to deliver the finest diagnostic, tuning, repairing and maintenance services!
A Highly Reputed Rolls Royce Service Center In Dubai
Located at 25th St, Al Quoz 4, German Auto Care holds a specialty in servicing the most extensive range of German brand automobiles, including Rolls Royce. We hold a reverence for perfection, and ensure that our clients leave our workshops completely satisfied with the quality of services delivered to their vehicles.
With a highly skilled and experienced team of Rolls Royce specialists, we are here to ensure that every single system, component and part of your prized vehicle is working perfectly. Whether your car requires basic maintenance, needs extensive diagnostics and repair, or just needs a bit of detailing and wheel alignment, we are here to assist you as best as possible while also ensuring that the integrity of your automobile is never compromised.
Give Royal Repair Treatment to your Rolls Royce
Rolls Royce is the emperor of the motoring world. This British Luxury car brand has made its presence felt around the globe for its high end features, unique design, unmatched craftsmanship and unbeatable automotive comfort. In fact, Rolls Royce has redefined luxury. Due to the astronomical price tag, only few customers afford Rolls Royce. Hence, only expert specialists have the right to repair any technical snag. German Auto Care is a leading Rolls Royce service center Dubai, known for providing excellent diagnostic, tuning, repairing and maintenance services.
Our team is fully certified to handle this super-luxurious brand. The mechanics of German Auto Care wholeheartedly dedicate themselves to provide the customer satisfaction of the highest level. Acquiring customer trust is never easy. Our technicians keep abreast of the latest emerging techniques. At our Rolls Royce service center Dubai, we give necessary attention to every section of the vehicle. We make sure that your high-value possession always attains attention of others and delivers impeccable performance.
It is not easy to retain the classy appeal of the Rolls Royce car. If you want to continuously enjoy the bliss of riding your supercar then perhaps German Auto Care is the best place.
Some additional reasons to select German Auto Care, the best Rolls Royce service center Dubai.
- Fair and transparent working system
- Swift and dependable servicing
- Ensuring customer satisfaction at all costs
- Sharing transparent quotations and taking approval prior commencing any work
German Auto Care provides complete Rolls Royce maintenance and repair solutions. Our service includes:
- Transmission repair
- Brakes repair
- Suspension repair
- Steering repair
- Transmission repair
- Brakes repair
- Suspension repair
- Steering repair
With several years of rich experience, we can effectively fix issues of your Rolls Royce models and successfully handle all your maintenance needs, whether big or small. Feel free to contact us to learn more about Rolls Royce service center Dubai.
Schedule An Appointment Today
If you wish to benefit from cost-effective, professional and specialized services for your treasured automobile, then make sure that you visit our workshop right away. Get your vehicle serviced by trusted experts – please feel free to book an appointment by calling us at +971 4 338 4535 today!


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Microsoft's secret Flow app sounds like a messenger app
Microsoft's Outlook mobile app, basically a rebranded app from newly acquired Accompli, is just starting to take root on Android and iOS. There is no rule, however, that says Microsoft can't start dreaming up and working on the next e-mail killer. A hidden download page for a certain "Flow" app for the iPhone was just discovered, and with it a description of what Redmond might be planning for its next stab at bringing its own brand productivity and communication to mobile platforms that aren't its own.
"Flow by Outlook". That sounds pretty close to "Inbox by Gmail". But while the latter is focused squarely on presenting traditional email in a different way, Microsoft's flow might simply be using email as a jumping board. Or to be more precise, instead of phone numbers, Flow will let you start a conversation with anyone who has an email address.
It's still email actually, or so the short description of Flow says. Everything it stored in your Outlook account, pretty much like how Gmail also keeps your Hangouts records. You can participate in conversations whether you're in the Flow app or in Outlook. It doesn't really matter. If you're only talking about Flow conversations. The rest of your non-Flow email from Outlook will be invisible to Flow.
What makes Flow different from conventional email is that Microsoft is doing away with the formalities. No subject lines, no salutations, no signatures. Just conversations, pure and simple. Except it technically happens over email. It would have the same effect if you simply didn't put a subject like, disabled signatures, and started yapping away. But Flow perhaps will make it feel more natural, less artificial. But it's still really just email.
There is no word on when Flow by Outlook would actually take flesh on iOS, and whether it will also take flight in Android. Given Microsoft's recent dance, that might be more probable than possible. It's a curious way of sugarcoating, or masking, emails to make them look less daunting or less formal. But it's all just email in the end.

subset: commoncrawl


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Friday, January 23, 2009
The Comic Book Heroes: The Marvel Age of Comics
Chapter 6 of Will Jacobs and Gerard Jones' 1985 The Comic Book Heroes, titled "The Fantastic Four," was heavily rewritten by Jones to become Chapter 7 of his 1997 revision, "With The Sudden Fury of a Thunderbolt." Jones placed heavy emphasis on the apocryphal nature of the infamous tale of a golf game between Jack Liebowitz and Martin Goodman. Supposedly the former bragged about the sales figures of the Justice League of America to the latter, who immediately demanded his cousin/nephew-in-law Stanley Lieber create a knock-off. Hence, the Fantastic Four was born, or so the story goes. The truth of the matter is less certain, as skin mag publisher Goodman was a slightly shady character. He burned through at least fifty corporate identities, often with several running simultaneously, to avoid any one's going under bringing down the whole "empire." As for Stanley Lieber, well, it's not like ol' Stan "The Man" Lee doesn't have a reputation for embellishing or misremembering the truth. "Others involved with the company have said that Goodman had a paid informant within Independent News," which distributed DC Comics, as well as his own.
Stan Lee had spent his entire professional life working under Goodman, and had been heavily influenced by the comic writers who had preceeded him at whatever his company was called on any given month. Of features like Namor the Sub-Mariner, the Human Torch and Captain America, the 1985 edition noted, "The elements embodied in these characters-- the antihero at odds with society, the extra-powerful being who is frail at heart, heroes who fight one another, and the hero as social or political symbol-- were to remain in Lee's mind through the 1960s." Jones continued in the '97 edition, explaining that Jack Kirby had first left Goodman's company over a royalty dispute, but was now cornered by strained relations with DC and the indifference of Archie back into returning to Goodman's fold. Lee also directed scripting jobs to his brother, Larry Lieber, and had fed newcomer Steve Ditko enough work to keep him from contributing much at Charlton. They combined to form the creative backbone of what would become Marvel Comics.
Kirby claimed he created the Fantastic Four all by himself, adapting his model from the Challengers of the Unknown to suit his new home. Lee claimed his authorship was inspired by a lecture from his wife to focus his attention on his comics work over random freelancing in magazines. Having spent all of his life inside comics, instead of doing time in the pulps like Schwartz, Weisinger & co., left Lee with no prose outlet for his more mature writing impulses. He instead directed them at his new project, the aforementioned Justice League swipe, and handed a two-page plot summary to Kirby. "What we can venture to say, after comparing their work together to their work with others, is that Kirby clearly appears to have done most of the plotting, and probably created most of the principle characters, but that Lee supplied all the dialogue and most of the character nuance. And that's probably enough to know, because it was their two talents together that made the Lee-Kirby, or Kirby-Lee, superheroes the most potent since superheroes were born."
You can buy the 1997 edition of The Comic Book Heroes: The First History of Modern Comic Books - From the Silver Age to the Present from Amazon.com.
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How to model a pipe Strainer / Filter in Basket or Y-type configuration with AutoPIPE?
In essence all of these piping components are model in similar ways using the procedure below:
Insert a 1.5 ft long component starting at node point B05, the weight of the piping component is 100 lbs, and weight of contents inside is 50 lbs. Flange connections are 300# rating. For analysis purpose, model has 4 Temperature / Pressure Load cases to be consider for design.
a. Set current node point to B05
b. Insert Slip-on flange set, 300# rating. "Insert Matting Flange" enabled
c. Insert Run to CG of the component, Length = 9", creating B06
d. Insert Run, Length = 9", creating B07
e. Insert Slip-on flange set, 300#.rating, "Insert Matting Flange" enabled
f. Select Node points B05 - B07, Insert > Rigid Options over Range, Include Weight = Disabled, Include Thermal Exp.= Enabled
g. Enter weight of Pipe Component
Here the user must use caution to ensure that the weight is correctly accounted for.
Options to apply piping component weight:
#1: Insert Weight at CG of the component
#2: Insert Distributed load over Range
1. AutoPIPE calculates the content weight of an typical piping component by multiplying: (inner pipe diameter) x (length of component) x (Pipe Property Specific Gravity) x (Analysis Set Density Factor [default=1]).
2. With inserting "Rigid Options over Range" in step above, the total weight of the component + contents were removed from that section of piping:
Notice how the Pipe and Contents weight were reduced by that section where Rigid Properties were added.
3. Insert> Weight values are accounted for during the Gravity load case.
Both Methods have Pros and Cons. Therefore, in this exercise use Option #1> Insert Weight at CG of Component.
Method A:
Select the CG node point and insert multiple weights to account for different items (ex. Weight of Component, Weight of Contents, etc..)
a. Account for Weight of the component - Insert> Xtra Data> Additional Weight, vertical Dy = -100 lbs
b. Account for Weight of the contents - Insert> Xtra Data> Additional Weight, vertical Dy = -50 lbs
Question: According to the modeling approach above, is the component modeled weight too heavy? or is the weight correctly modeled at exactly 150 lbs?
Answer: Correct, the model component weight is too heavy. Remember how the flanges were modeled above, mating flanges were added, therefore there are 2 flanges who's weight has been added to this piping component. Solution, either change 1 flange at B05 & B07 equal to 0.00 lbs. Or, subtract the total weight of the flanges at B05 & B07 from weight of component.
c. Either change 1 flange at B05 & B07 equal to 0.00 lbs. Or, subtract the total weight of the flanges at B05 & B07 from weight of the component.
Method B:
Delete 1 flange from B05 & B07, and insert the total weight of contents and weight of the component all at one time.
a. Select CG of the component (ex. B06)
b. Account for total weight of the component & contents - Insert> Xtra Data> Additional Weight, vertical Dy = -150 lbs
Finished modeling the piping component.
Modeling a Filter or Strainer component are fairly similar; model 2 sets of flanges on a section of piping to represent the Filter / Strainer body, insert rigid options over length (ignoring weight while considering thermal expansion), add a weight for Filter / Strainer body at the mid point, and add another weight at the same mid point for weight of Filter / Strainer contents.
This modeling approach does not automatically remove the contents weight of the Filter / Strainer if the "Contents " option is disabled in an analysis set. Remember, If one wants to run an analysis that does not consider weight of contents than delete the weight value from step G above before running an analysis. And, reapply this weight value when contents are to be considered in an analysis.
Method #2 - Model Y-strainer
Model Different Types of PIPING Components
Bentley AutoPIPE


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Heddiw (Dydd Gwener), mae 'Herald Wales' yn cael ei lawnsio: platfform newyddion dwyieithog ar-lein; ac yna ddydd Llun, bydd 'The National' yn ymddangos. Darllen Mwy
Mis: February 2021
(English) Looking On Aghast From Here
(English) Watching Scotland's own version of 'Watergate' unfold in front of us right now is a very disturbing process. Darllen Mwy
(English) Party Rewards Their Cronies
(English) Crony politics in the UK has been highlighted again after an 'unlawful' £18 billion spend by a leading Tory politician. Darllen Mwy
(English) Don't Shoot The Messenger
(English) Bryn Terfel's reported comments -'I mean, I would have to look at what independence would mean for me personally' – have an undeniable ring of truth to them. Darllen Mwy
(English) Abuse of Public Position
(English) A prominent Welsh politician has been savaged by a crown court judge for 'abusing' her public position. Darllen Mwy
Cyhyr Economaidd yr Iaith
Cafwyd enghraifft ddoe o'r Gymraeg yn ymarfer ei chyhyr economaidd am unwaith yn ein gwlad. Darllen Mwy
(English) Crisis Needs a Citizens' Income
(English) As a party, Gwlad believes in a small-business driven economy which gives all stakeholders an equal opportunity within a free market. Darllen Mwy
(English) Feeling The Fear From Here
(English) Attacks on Wales, and the Welsh language in particular are couched in much more primal terms, betraying a deeper sense of fear and loathing of an identity which is essentially unknowable. Darllen Mwy
(English) Grim Takeaway For Voters
(English) Once again, the shocking inconsistencies of leafleting in lockdown Wales has been exposed. Darllen Mwy
Yr Achos Dros Fis Medi
Ddoe cytunodd aelodau'r Senedd i fesur a fydd yn caniatau gohirio etholiad eleni am hyd at chwe mis. Darllen Mwy


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Easy maintenance
- Electrical submersible pumps by Wacker Neuson are extremely durable and safe to run dry. Additionally, regular maintenance supports long service life of the pumps. All maintenance points are easy to access and can be completed with a few steps.
- Oil drain screw accessible from outside
- Seals and shaft sleeve can be reached by removing just four screws


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Opened in June on Orlando's International Drive, the new $10 million Orlando StarFlyer from Funtime is the world's tallest swing ride, standing at 450 feet (137 m). It has 24 seats (12 x 2 seats), has no age limit and the minimum height for the ride is 44 inches (112 cm). Guests are seated in a double seat next to their friend, family or partner and are secured in their seats with seat belts and an in between the legs harness that can only be unlocked by the ride operator. Riders move up and down and rotate around the tower at speeds of up to 45mph (72 kph).
Funtime has been manufacturers and operators of high thrill amusement attractions for over 25 years. Funtime designs, engineers, manufactures, installs, operates, and have built and installed over 130 attractions in over 25 countries on every continent around the world. The Funtime attractions are built in Austria and have been present in the US since when the Old Town Slingshot was installed in Kissimmee in 2001.
The Starflyer arrived from Austria in 28 40-foot shipping containers and required 1000 tons of steel, 6000 feet of steel cables, 8000 feet of electrical cables, 110,000 bolts and was all built on site. The foundation required 1400 cubic yards of concrete (140 trucks), 75 tons of steel, is 88 feet in diameter and the concrete was poured continuously for 8 hours from midnight until 8 a.m. to avoid the heat and traffic.
Less than a mile to the north on International Drive, a smaller 230 foot (70 m) StarFlyer operates at Magical Midway. Riders can see one from the other.


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Expecting Father and Mother down on Saturday so got Lieut. Dobell to fix up with Colour Sergt. that I should have no duty of any sort on Sunday.
Nov 14th.__
More manoeuvres and bayonet drills. Met Father and Mother at Canterbury West Station and they came to Colbrans for tea, and we had a good talk afterwards.
Sunday. Had a nice afternoon with the folks who left early the following morning.
Monday. Marched 5 miles and then split up in 4's and came home across country which we managed easily as the Cathedral is a good land mark and we spotted it from the top of a hay stack. Short drill in afternoon.
Tuesday. Skirmishing etc. Outpost duty in the evening. I was on reconoitering patrol and we had a nice stroll up and down between the various groups of sentries.
Wednesday. Shooting on a miniature range
Met Father and Mother at Canterbury Station


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KTM 790 Duke India launch on September 23
- The highly-anticipated KTM 790 Duke will launch in India on September 23. It will be the first time that KTM will launch a bike larger than its 390 range in the country.
- Globally, the 790 Duke uses a 799 cc, liquid-cooled, parallel-twin engine which generates 105 bhp and 87 Nm. However, it is rumoured that the India-spec model might be slightly detuned to better suit the country's low-quality fuel.
- Features expected on the bike include a two-way quick shifter, 4 riding modes (Sport, Street, Rain and Track), 43 mm WP USD front fork, WP rear monoshock, 300 mm twin front disc brakes with radially-mounted 4-piston callipers, dual-channel ABS, etc.
- In terms of design, the bike looks like a beefier version of the current 390 Duke. Its high-set muffler on the right is definitely a unique design element.
- Expect the KTM 790 Duke to cost around Rs 8.5-9 lakh (ex-showroom) in India. At this price, it will directly lock horns with the Kawasaki Z900, Triumph Street Triple S and even the Suzuki GSX-S750.


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Eco Friendly Packing Guide - October 21, 2019
When you add up all the costs of a move, you might find yourself paying more than you bargained for. While you might have saved up enough in advance, you shouldn't throw money around. One of the ways in which you can cut some of the expenses is to use household items that serve as packing supplies. Also, to save money as well as the environment, you can rent moving supplies from a local moving company. However, in this article, we will focus on the things around your home that you can use for packing. Take a look and learn how you can make the most of them!
Household items that serve as packing supplies – use plastic bins
When it comes to packing supplies that you can reuse, plastic moving tubs top our list. Many people use them to store seasonal items such as winter clothes, but also for perishables and canned goods. A good way to use them for relocation is to put your electronics and appliances inside. These tubs are waterproof and will keep everything inside completely dry. This is especially useful if you are moving during bad weather, such as rain or snow. Also, one of the best features of plastic bins is that you can reuse them again after your move.
Get out your linens and towels
When you pack fragile items such as china, glassware, mirrors, etc., you need to ensure that there is no chance of breakage. Instead of buying plastic bubbles, you can use your towels and linens to wrap each item. That way, you pack both your breakables and your linens in one go. Start by placing a sheet or a towel at the bottom of your moving box. Next, wrap the item in a sheet and place it inside. Finally, put one more towel on top before closing the box securely. If there is enough room, you can even pack multiple items in one box. Just make sure that there is no room for it to move during transport, as it might scratch or even break.
Suitcases are among household items that serve as packing supplies
Traveling often means a lot of bumping and bouncing, so most suitcases are made to endure such impact. That is why they are among the best household items that serve as packing supplies. If you haven't used them in a while, make sure to clean them out before you put anything inside. That way, you will keep your new home clean while you unpack. While they are excellent for packing clothes and books, you shouldn't use them to pack anything fragile. They are not meant for protecting delicate pieces and you might end up with a suitcase full of shards. Instead, pack as many clothes as you can inside the suitcase.
Before you start packing it up, check to see if there is a lock on your suitcase. If there is one, you are in luck. A lock will ensure that your suitcase doesn't open on its own during transport, but it also guarantees theft prevention. Due to this feature, you can place your jewelry inside and know that it is safe during relocation. Finally, you can use your suitcase to pack your essentials bag, with everything for the first couple of days after your move. You have many options with a quality suitcase, so try to make the most of it.
Use the trash bags you have in your home
Nobody likes to spend their first day in a new home washing and ironing clothes. To prevent this, you should know how to pack them the best way possible. Grab a couple of trash bags from the kitchen and head for the closet. Instead of taking every piece of clothing off the hanger, folding it, and placing it inside the box, you should try a different approach. Make a hole in the trash bag and place it over your clothes while they are still on the hangers. This will prevent them from getting dirty and wrinkling during transport.
While you've used your trash bags efficiently, you can also use the plastic trash bin in your kitchen. Wash it as well as you can and use it to keep your cleaning supplies and products while you are moving. If there is a handle on the bin, all the better. Keep these cleaning supplies close as you pack so that you can take care of a mess as soon as it is created.
Clothes are definitely household items that serve as packing supplies
Just like with linens and towels, you can use clothes when you pack your household. You must have some old T-shirts in the back of your closet. Use them to wrap fragile items or to fill any empty spaces in the boxes. Another useful tip is to use your old socks to store some smaller knick-knacks. Simply place them in the sock and tie the end into a knot. For extra protection, you can use more than one sock for an item.
A great way to save space when relocating is to fill the insides of your shoes with smaller items. For example, you can ball up your socks and place them inside instead of packing them separately. If you are moving the shoes inside shoeboxes, you can even stuff the box with some rags or smaller towels.
Don't throw out old newspapers
Before you start packing for your move, look through your house for old newspapers. Believe it or not, newspapers are among the household items that serve as packing supplies. While you declutter, make sure to keep at least a dozen of them for packing purposes. They are a great, practically free, alternative to packing paper. Use the newspapers to wrap some of the more fragile items, such as mirrors. However, avoid using them to wrap fine china, as the print may transfer and leave a mark. Finally, you can use newspapers to stuff each box and ensure that the items inside don't touch or scratch during the move.


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Our Execution Model
RadiumSpark's execution model operates at the junction of business & technology. In today's world technology is constantly changing with lightning speed and every organization wants to take advantage of these dynamic opportunities. We are one stop solution for your business, technology & operational needs. We drive with our Unique Risk Management Principles right from concept phase to shape new businesses with futuristic approach.


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27 A POPLAR DR, Richmond Hill, Ontario, L4E1C9
Absolutely Stunning! Custom design Approx 6198 Sq,Ft of Living Space In High Demanded Area Of Richmond Hill. High End Finishes Through out. Main Floor Office With Fireplace ,With High Ceiling Of 10 And 11 Feet ! This family home has 4 large bedrooms with 4 ultra Large Walking in Closets. 2nd Bedroom Can Be Used As Master With W/I Closet. Large (Linen Closet) Perfect For Large Family With Lots of Parking Spaces of 12 Or Great Income Property. The Finished 2 Bedrooms, 2 Bathrooms, Walk-up Separate Basement. The Professionally Landscaped With Mature Trees, Fenced Backyard With Glass Railed Deck With Wide Steps To Stone Landing.**** EXTRAS **** S/S Appliances. 2Fridges ,One With 42'' With Ice Maker, 2 range hoods, 2 stove, 2 Washers, 2 Dryers, Ac, Build in Wall oven and warmer! Build in microwave, Shelfed Pantry kitchen, Pot Lights, Dimmers, Exterior Pot Lights! Sensor Lights! (id:2471)
- Douglas: 416-399-6853 | Brooke: 416-346-4499
- 416-925-9191
- firstname.lastname@example.com
- Property Address: 27 A POPLAR DR, Richmond Hill, Ontario, L4E1C9
- Community Name: Oak Ridges
- Property Type: Single Family
- Title: Freehold
- Lot Size: 64 x 111.78 FT ; 41.05 Plus 23.29
- Acreage: 64 x 111.78 FT ; 41.05 Plus 23.29
- Driveway: Attached Garage
- Total Parking Spaces: 8
- Structure Style: House
- Style: Detached
- Storeys: 2
- Bedrooms: 4 + 2
- Bathrooms: 6-Total
- Basement Type: N/A (Finished)
- Heating Type: Natural gas, Forced air
- Cooling: Central air conditioning
- Exterior Type: Stone
- Fireplace Present: True
|Primary Bedroom
|Second level
|6.1 m x 3.08 m
|Bedroom 2
|Second level
|4.88 m x 3.66 m
|Bedroom 3
|Second level
|4.88 m x 4.33 m
|Bedroom 4
|Second level
|3.98 m x 3.66 m
|Lower level
|Measurements not available
|Living room
|Main level
|5.88 m x 4.8 m
|Dining room
|Main level
|5.88 m x 4.28 m
|Family room
|Main level
|6.06 m x 4.88 m
|Main level
|3.3 m x 3.08 m
|Main level
|3.98 m x 3.7 m
|Eating area
|Main level
|4.28 m x 3.48 m
|Main level
|2 m x 1.2 m
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Vaccination has worked wonders to drive down deaths from infectious disease. A few hundred years ago, less than 60 percent of children saw their fifth birthday. Now, 95 percent do. Vaccines — against smallpox, measles, polio, diphtheria, and more — have driven that progress.
But one of childhood's biggest killers — malaria — has eluded effective vaccination. That, at long last, looks to be changing.
In a recently concluded clinical trial conducted by researchers from Oxford and the Clinical Research Unit of Nanoro, Burkina Faso, a new malaria vaccine called R21/MM demonstrated 77 percent efficacy in children in Burkina Faso. That's a dramatic increase over the efficacy of the only currently available malaria vaccine, RTS,S, and might represent a huge breakthrough in the fight against the disease.
Malaria infects hundreds of millions of people every year and kills hundreds of thousands, mostly young children and pregnant women. It has been one of the top killers of children for thousands of years, and still is today. For most of history, it ravaged warm regions the world over. But in the 20th century, it was successfully eradicated from much of the world through insecticide spraying. In sub-Saharan Africa, though, it has remained a major threat — and climate change means that the geographic range the malaria-carrying mosquito can survive in has expanded.
Unsurprisingly, a malaria vaccine has been a major priority for researchers. But malaria has proven absurdly difficult to vaccinate against. It's caused by a parasite, not a bacterium or virus, and the parasite's functioning in the body includes suppressing the immune response. For many diseases, infection leaves you immune for life, but it's possible to catch malaria over and over again. And for many diseases, a vaccine just involves exposing the body to a dead or attenuated version of the disease agent. But that doesn't really get results with malaria.
Fortunately, vaccine science has been rapidly advancing, and these days we can do far more than simple exposure vaccines. While the R21/MM vaccine doesn't use the specific technologies that led to an unprecedented vaccine against Covid-19, it's part of the same overarching story: Scientists are getting better at designing highly effective vaccinations, and their triumphs will be a huge part of the fight against death and illness in the 21st century.
Why it's hard to vaccinate against malaria
The Plasmodium parasite that causes malaria in humans needs both blood-sucking insects and humans for its life cycle. It grows inside a mosquito and is transferred to a human host when the mosquito bites them. Then the parasite migrates to the liver, replicates itself, and infects the blood — where it can be taken up by the bite of another mosquito.
When the parasite is in the blood, it causes fever, chills, and flu-like illness. Healthy adults usually recover, but those with a weaker immune system — especially young children and pregnant women — can easily die. (Older people who live in regions where malaria is endemic are, surprisingly, not especially vulnerable. The theory is that after sufficient exposure to malaria over a lifetime, the immune system develops a general anti-parasite response that might be more durable than malaria-specific immunity.)
Vaccinating against malaria is tricky. Parasites have much more going on than viruses, making targeting a vaccine harder. Multiple life stages have been explored as vaccine targets, mostly without success. "Malaria vaccine [development] has been a graveyard for really great ideas," Derek Lowe, a researcher who writes about drug discovery, told me. "We've learned about a lot of stuff that doesn't work." Targeting the parasite once it's in the blood, for example, has been tried repeatedly but never succeeded. Exposing the body to dead or neutralized Plasmodium? A dead end. Researchers have been working on this for decades, and progress has been rare.
The earliest success stories of vaccination involved vaccines against diseases that produce lifelong immunity, like smallpox and polio. Those are viruses, so they're much simpler to target. And since you can't be reinfected with those diseases, the vaccine only needs to provoke the same immune response as the disease did originally, and the patient is safe for life.
But in the case of malaria, naturally acquired immunity against malaria typically is only partial and fades out in a few years. Researchers have been working for decades to figure out how a vaccine can induce durable immunity, and most of that work has ended in frustrating failures. The only vaccine approved for malaria today, RTS,S, has been around since 2016. While it's much better than nothing, it's not great — it has an initial efficacy of around 55 percent, and annual booster shots are needed.
R21/MM, the new vaccine, represents a significant improvement. At 77 percent efficacy — meaning that a vaccinated person is 77 percent less likely to get malaria than an unvaccinated person — it could cut malaria deaths dramatically.
That said, the new vaccine still doesn't quite stack up to the efficacy of vaccines for other childhood diseases. The measles vaccine is 97 percent effective, for instance, and one dose of the chickenpox vaccine prevents 85 percent of cases and nearly 100 percent of severe cases (a booster shot brings efficacy up to 98 percent).
But there's no question that the new vaccine is a huge step forward. If the efficacy statistics from the phase 2 clinical trial (the first test of safety and efficacy in the target population) hold up in phase 3 (when the vaccine is distributed on a much larger scale, so that its efficacy and safety can be evaluated with more information, and compared against the existing best treatment), the vaccine will have the potential to save hundreds of thousands of lives every year once it's distributed widely throughout malaria-affected areas, primarily sub-Saharan Africa.
How the new vaccine works
The R21/MM vaccine is what's called a pre-erythrocytic vaccine, which means it targets the malaria-causing Plasmodium parasite during the earliest stages of its life cycle in the body, before it multiplies in the liver and enters the bloodstream. During this stage, malaria doesn't yet have any symptoms; the plasmodium sporozoites grow silently until they release their next life stage, merozoites, into the bloodstream.
Many candidate malaria vaccines try to help the body target and destroy the parasite at the pre-erythrocytic stage, including RTS,S, the existing malaria vaccine. If the body can learn to recognize and have an immune response to the parasite at this stage, it can prevent it from multiplying in the liver, entering the blood, and causing symptomatic malaria.
Exposing the body to the malarial parasite isn't itself enough to create durable immunity. Fortunately, modern vaccine researchers have a lot more tricks up their sleeves. The R21/MM vaccine targets a specific protein present on the surface of the Plasmodium parasite in its sporozoite form. (RTS,S targets the same protein — earlier research has established that it's a particularly good target — but exposes the body to less of the protein, due to differences in the structure of the vaccine.)
Targeting a single protein can produce better-targeted and more consistent immunity than exposing the body to the whole disease agent. When the body is exposed to the whole disease agent, it's hard to predict exactly what it will "learn" to fight. Showing it a single target protein ensures it'll develop the antibodies scientists have determined that it needs the most. And the protein that R21/MM and RTS,S target is one that researchers have determined is very unlikely to mutate or vary among strains of malaria.
The next step of a successful vaccination is what's called an adjuvant, an additive to the vaccine that kicks the immune system into higher gear. Protein-based vaccines are generally understood to need an adjuvant, because the body will not necessarily react to unfamiliar proteins by mounting a full immune response.
"What those do," Lowe told me, "is they're a totally separate ingredient that has nothing to do with the pathogen. But they basically set off your innate immune system that's always there, surveilling for foreign-looking crap." What makes a great adjuvant? Something people have strong reactions to. As long as the body finds it irritating and mounts an immune response, it can function as an adjuvant.
The research team behind R21/MM tested many different adjuvants to figure out which one provoked the strongest immune response, and the winner was a formulation called Matrix-M (that's the MM in the vaccine's name), an extract from the bark of a Chilean soap tree. Matrix-M is a proprietary invention of Novavax, also used in its highly effective Covid-19 vaccine.
This research has been in the works for years. In 2016, a trial was conducted in healthy adults in the UK, looking at the R21 vaccine alone and with the Matrix-M adjuvant. After success in the UK, another trial in healthy adults followed — this time in Burkina Faso, where malaria is endemic.
Once that early research was established to be safe, the research team began conducting studies in steadily younger cohorts. The group at the most risk from malaria is infants, but it's generally easier to see if vaccines have health risks or side effects by looking at older cohorts. Once the vaccine was determined safe, research began in 5- to 17-month-old babies in Nanoro, Burkina Faso.
The R21/MM vaccine is administered with three shots, plus a booster shot one year later. That means distribution of the vaccine will be a real challenge, especially in poor areas with limited health care infrastructure, but it's an improvement over RTS,S, which requires four shots for a full course of vaccination and, again, is significantly less effective.
In the phase 2 study published this week, researchers found that the R21/MM's single booster shot a year later returns immunity to the full level achieved after the initial course of three shots. The results are "very exciting," Halidou Tinto, the principal investigator for the trial in Nanoro, said.
Phase 3 trials begin right away at five sites across Africa, in order to test how the vaccine works in areas with different malaria prevalence. "We look forward to the upcoming phase 3 trial to demonstrate large-scale safety and efficacy data for a vaccine that is greatly needed in this region," Tinto told the BBC.
The phase 3 trials might also help clarify whether all three shots and the booster are necessary, or whether there's a way to induce good protection with a less demanding dosing regimen. With any luck, within a few years we'll have the efficacy, safety, and dosing data needed for a rollout across malaria-afflicted areas.
The big picture
Malaria isn't just one of the world's biggest killers of children. It's also one of the biggest barriers to good childhood health and development in affected areas. Malaria infection causes long-term problems including cognitive impairment, and likely has long-term developmental impacts on children even when they survive it.
The world has done a lot over the past few decades to fight malaria. Interventions like insecticide-treated bed nets and seasonal preventive treatment in the form of medications have driven death rates down from around 1 million every year as recently as the 1990s to around 400,000 today. But without an effective vaccine that can be distributed everywhere, it's going to be incredibly difficult to eradicate the disease.
Researchers know that, and malaria vaccine research is one of the most active areas of vaccine research, with human challenge trials in the UK (meaning clinical trials where volunteers are deliberately infected with the disease), phase 1 and phase 2 clinical trials throughout areas with high malaria prevalence, and other promising ideas being pursued based on encouraging results in mice.
Now, all that effort is starting to pay off. In general, writing about malaria vaccines means emphasizing that everything is still early-stage, that there's lots of reason to expect a new innovation or development to fall through, and that while every avenue is worth pursuing, the public should know that most of them won't pay off.
That's not true this time. This is a late-stage result, and there's every reason to expect it to hold up. "This is excellent work," Lowe told me. "This is the best news in the malaria vaccine world ever."
This is the first vaccine to meet the World Health Organization's threshold of 75 percent effectiveness for a malaria vaccine. With many other vaccine candidates making their way through trials, it almost definitely won't be the last. The more we know about malaria — and about vaccination — the better we can design vaccines that are cheap, simple to store and administer, that don't require too many booster doses, and that provoke a strong and enduring immune response.
For more than 100 years, vaccination has been one of humanity's most powerful tools against disease. It's a tool that gets more potent every day, as we learn more about what makes vaccines work and how best to point our immune system at the perfect target.
This latest development is worth celebrating. It's an innovation that could mean saving the lives of hundreds of thousands of children. And if it fills you with optimism about the prospects of a world where vaccines inch us closer to eradicating diseases that have long plagued humanity, it should.


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In the dim dark days before Pokemon there were sports cards, and what could be
more Canadian than a story about hockey cards? Here we have a little story
which has the potential to rank right up there with Rock Carrier's "The
Hockey Sweater".
Comparisons will be obvious since both stories, each in its own way, celebrate the career
of Maurice "the Rocket" Richard.
The narrator is a nameless young boy who loves hockey as much as his father and his
Uncle Jack. In fact, the story is Jack's, which he tells to the boy as a bedtime story.
Jack used to play games with his cards. Not for him the sealed mylar card envelopes of today. No, these
boys used to play their cards like marbles, flipping them in games of odds and
Jack's tale is about the great game where he lost almost all of his cards and was then miraculously saved by the Rocket.
It's a tale with lots of tension, illustrated in a lively style.
One of the cute tricks in the pictures occurs in the upper left corner of each two
page spread. At first there are two hockey cards up there, but as the story
progresses they come to life, the players step out of them and play the game
along with the boys, moving about the
pages as the story continues.
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Iowa's public universities provided $11.8 billion in additional income to the state economy in the 2017-18 budget year, according to a new study conducted by Idaho labor market analytics firm Emsi.
The economic impact report, commissioned by the Board of Regents and unveiled last week, found that Iowa public university activity supports nearly 150,000 jobs, or one in every 14 jobs in the state.
The University of Iowa in the 2017-18 budget year added $6.5 billion in income to the Iowa economy. That's equal to 3.4 percent of the state's total gross product and amounts to 81,073 jobs, according to the report.
Iowa State University in the 2017-18 year added $3.4 billion in income to Iowa's economy, amounting to 1.8 percent of the state's total gross product and supporting 42,640 jobs.
UNI added $1.6 billion to the Iowa economy, equal to nearly 1 percent of the state's gross product or 21,979 jobs.
Click here to read the entire economic report.
New St. Luke lab allows staff to create healthcare inventions inside the hospital
St. Luke's Hospital in Cedar Rapids opened its new innovation lab on Thursday.
The "Generate Health Technology Fabrication Lab" in Cedar Rapids is MakerHealth's third space like this in the country, and is the first in the Midwest.
If hospital staff have an idea that they think can help their care, they can brainstorm with a product engineer, then build their product with 3D printers, laser cutters and other technology.
Prior to the permanent lab opening, the hospital ran a similar operation through pop-up labs in empty rooms at the hospital. Through that, staff members created nearly 60 different projects, 11 of which are currently used at St. Luke's and its clinics.
In addition to the lab at St. Luke's Hospital, there will also be two smaller, satellite labs at Witwer Children's Therapy in Cedar Rapids and Hiawatha.
Kirkwood STEAM Institute set for Nov. 25-26
Kirkwood Community College's Workplace Learning Connection (WLC), a work-based learning program for middle school and high school students, has partnered with more than a dozen regional businesses and organizations to host the Johnson County STEAM Institute on Nov. 25-26.
The two-day event will provide seventh-grade students from Johnson, Benton, Cedar and Iowa counties a chance to learn about various opportunities in science, technology, engineering, art and math (STEAM) careers. More than 1,750 students are expected to take part in more than 5,000 unique STEAM experiences.
The experiences are designed to spark interest in middle school students and inspire them to pursue job shadows and internships while in high school. In recent years, WLC has experienced a spike in student job shadow and internship placement at local businesses. The organization attributes this growth to strong community partnerships and hands-on events like the STEAM Institute.
The event will be held 9:30 a.m.-2 p.m. at the Kirkwood Regional Center at the University of Iowa.


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Twine & Twig Intricate Stack Bracelet | Desert
Regular price$50.00
- Low stock - 1 item left
- Inventory on the way
Fits wrist size approximately 7".
The Twine & Twig Desert Collection is inspired by the blend of colors that sunlight creates as it hovers over the sandy stretches. This neutral combination of hues is the perfect accent piece to add a little gold glimmer to any outfit. The Twine & Twine Intricate Stack is designed using globally sourced beads. They can be worn individually or stacked up.


text: UncategorizedFinally…Our New Sofa Story and the End to a Long Drama-Filled Saga August 28, 2013Alright, longest title in history award goes to yours truly. But if y'all have been around here for very long, you know that finding the right new sofa has about killed us. Remember the epic sofa saga? And then the one that we got for $130 at a thrift store to reupholster? Yes, I know. I thought we were done there too. Well, done until it got reupholstered. But if you follow me on Instagram (lifeofsplendor), you know that two weeks ago, we took a little trip. Yes, we drove 2.5 hours each way the night before I started back to school for a sofa that we'd seen a picture of on Craigslist. Crazy? Maybe. Okay, yes definitely crazy, but that's what design does to me, y'all! Some of you asked why we went looking for another couch in the first place. Didn't we have one that I loved? Yes, I adored the couch above. I adored the shape, the comfort, and how I knew it would look reupholstered. What I didn't love was the quote that I got for reupholstering it. I had been given a cheaper quote when I bought this and then that one fell through. After that, the cheapest quote I got including fabric was $700. Now, I recognize that probably isn't that unreasonable for re-upholstery. But for this bargain hunter, I couldn't do it. I want a nice and comfy couch, but there is still so much I want to do in our house now that it's finally ready for decorating and furnishing after all of our renovations. We're on a budget and $700 could go a long way… I actually considered reupholstering it myself. I'm a DIYer, right? How hard could it be? I've got to be honest…I was too scared to try. And I want a couch so I can finish the living room like yesterday and I know I won't have time to tackle that kind of project for a while. So, I just started looking. I wasn't sold on buying a new one and selling the striped one, but I wanted to see what was out there. I was looking for either mid-century style like this one or something lovely and leather and tufted like this beauty from Little Green Notebook. Within a few days, I found her. Genuine Australian leather, lots of tufting, nailhead trim, only two months old without a bit of wear, and the "worn" leather look that I love (think Pottery Barn leather – not perfectly smooth and new looking on purpose!). They said that it was a custom designed Bernhardt sofa. Have y'all heard of that brand? I hadn't, so I did some research. Their website reminds me a lot of Restoration Hardware. There were no prices, but I could tell these are seriously nice sofas. I thought, "surely there has to be a catch!" She was asking $500. I thought by looking that this sofa retailed for at least twice that and she said she'd only had it for two months. We had to go check it out… So off we went and what an adventure it was to bring this beauty home. I apologize for the long-winded story that follows, but I'm still in disbelief about what it took to get a couch. We drove, and drove, and drove deep into the mountains of North Carolina. The last e-mail I'd gotten from the sofa owner said they were the second house after you went through the gate. We were assuming a gated community. Well, about thirty minutes after we lost cell phone signal, we came to the gate. This was no gated community. It was a gravel road with a metal gate used to block off the road. It wasn't that we needed some place "nice" or that we were being judgmental, but Chris and I both got a little weary. This was a Craigslist deal after all, and we were out in the middle of nowhere with no way to reach anyone. Against our better judgement, we continued through the gate and came to the house with children playing out front and the nicest lady you'll ever meet sitting on the front porch. We immediately felt better. We walked in, LOVED the couch, and paid her. She did tell us that her mother in law works for Bernhardt and got this sofa after someone custom ordered it and then didn't want it, so they got it on a huge discount. It was even nicer in person that we expected and weren't shocked at all when the lady told us it retailed for $2,000. What?! We loaded it up and headed home. Well, here's where it got really interesting…we got lost in the mountains. With no cell phone signal. Our GPS must've been feeling adventurous that night because it took us home a different way than we came. This different way included a one hour trek up the scariest road I've ever been on: gravel, climbing up a mountain, huge drop off on either side, extremely windy, you get the picture. Every minute I knew that we were either going to drive off one of the sides and be killed or at least stranded without a phone or someone was going to run out of the woods and block the road and who knows… I didn't let myself think further. That is until Chris goes, "This reminds me of a serial killer movie I've seen…." My quick response was, "That is not helpful right now." Ha. Looking back, that's exactly what it felt like. And would you believe during this that my recurring thought was, "Gosh I hope the sofa doesn't fall off the back of the truck. Oh and Lord please don't let it rain because we forgot a tarp and this sofa's leather and they're calling for a 40% chance of showers." Crazy I tell you… After an hour of this, we came back to the lady's road. Right.where.we.started. That was fun. We kept going, found the right turn this time, and finally found our way home by around 12:30pm. But y'all, she made it home. And I seriously love her. Here she is in her new home in our living room. Now, I know what y'all long-time readers are thinking. Girl, you are seriously crazy. In the last house, I swore I'd never have anything but a white couch and here is a dark brown beauty in all her glory. I know, I know. Maybe my husband is right…I do change my mind quite a bit. I have a lot of plans to lighten up the room in other ways. I have to compensate for this new dark addition 🙂 I'll talk about those tomorrow. But for now, here's a few more couch photos. Oh what we went through to bring you home. Tomorrow, I'm going to talk about that rug that you spy in these pictures as well as reveal some of my plans for FINALLY finishing up our first and most important room! *** Oh and sorry for my unusual absence at the beginning of this week. I've been swamped working on something BIG I'm unveiling really soon. Hopefully next week!!! I can't wait to share. I hinted at it here in maybe my most popular post of all time. Who knew a motivational post about buffaloes would get such a reaction? Thanks for all of your sweet feedback 🙂


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Horner: "Nowhere to ease back in this year's Worlds course"
Veteran present in '98 Valkenburg Worlds team
A protected rider in the nine-strong USA team in today's world championships veteran Chris Horner is certainly not lacking in experience when it comes to the road race. Indeed, Horner, 40, was part of the US team way back in 1998 when the World's was last held at Valkenberg and with countless Amstel Golds under his belt, Horner knows the course like the back of his hand - and he warns it's constantly undulating, technical nature makes it very hard to predict.
"On a course like this, I'd expect a break to go maybe 75 or 60 kilometres from the finish," Horner told Cyclingnews as he prepared for the start in Maastricht.
"I've done this race before, of course in 1998, when it was rainier although not colder - although the rain made it feel colder than it is today - and I expect that the winning move will go before the last time up the Cauberg."
Back in 1998, Horner worked for Lance Armstrong, who took fourth following his fourth place in the Vuelta that autumn. "It was his big comeback, he did the Vuelta and then rode a fantastic race here. It was when we first knew that Lance was back to winning again."
Fast forward 14 years and now it's Horner who's one of the protected riders in the US team. "I've just got to see if the legs are good. I came off of a little break after Colorado [where he finished 13th - Ed.] and I've had three weeks training since the break, and that's usually what I need to come really good again. Maybe it'll be later in the week or hopefully it'll be today."
"I'm well-rested after Colorado, I've been at altitude for a solid six weeks and now I'm coming down to sea level. I'm familiar with this course, and I love being in Amstel [country] I did the Worlds in 1998 and my first Amstel in 1997. But the fans are very intelligent, enthusiastic and I expect numerous so it's going to be a great day."
As for where important moves could go, Horner says "The whole course is really historic. It is one where you have to be alert and on your toes the whole time, there's nowhere to 'take a nap' or ease back. You're never bored and the time is going to pass really fast. It's 250 kilometres full on."
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Like last season's marksman update and the mid-season mage update, the assassin class of League of Legends champions is scheduled for a facelift. We already know which four champions are getting major reworks, with details already announced on Rengar, Katarina, Talon and LeBlanc, but Tuesday we got a little more information on some of the other impending changes.
For one, how stealth works is going to be changing a lot. We already knew that was happening because of the details of the Rengar update, but now we know a little bit more.
Stealth will be broken into two different types:
Invisibility - shorter-term in-combat Stealths that make champions completely unseen such as Kha'zix's Void Assault.
Camouflage - longer-term pre-combat Stealths that can be detected through proximity such as Evelynn's Shadow Walk.
Perhaps the biggest change is that pink wards will no longer detect invisibility. You can expect changes for how invisibility interacts with other abilities as a result.
Simply put, Invisibility being trivially countered by the use of a relatively cheap single consumable item rendered several champions non-functional especially at high levels of play. This will allow us to better balance these champions since they will now be able to more readily utilize their Invisibilities in fights such that they no longer have to solely rely on instantly bursting their target or dying to enemy focus fire.
One example given for a balance change is a shimmer when you hit stealthed enemies with a skillshot.
In addition to the invisibility changes, there will be alterations to the flat armor penetration system and to assassin itemization.
Perhaps most importantly, the list of champions that will be receiving small updates was released. They are all included below, with Statikk's reasoning and context in the post for each.
Akali is another champion we believe needs a full Visual Gameplay Update to realize her full potential. Despite that, we're exploring some small scale changes that will give her more ways to outplay her opponents, but are also looking to resolve some of the gameplay health issues that stem from her split identity as both a bursty Assassin and a sustained Fighter. On top of this, Akali will be one of the major beneficiaries of the Pink Ward no longer detecting Invisibility change as it was one of the primary ways to shut her down previously - moving forward Akali and her target should both have a bit more time to breathe in the midst of combat.
Although not strictly an Assassin, we felt this was an opportunity once again to better align Ekko with his intended gameplay and fantasy; we are continuing to push Ekko away from being a pure Tank and instead more towards being an AP damage threat. Even though we've been inching him in that direction for a while, we think some minor shifts here will go a long way into solidifying his identity.
We're looking to retain Fizz's unique arsenal of evasive tricks but force him to make hard decisions about when and where to use them by giving Fizz more incentive to play with his food before he ultimately feeds them to his Shark. We also want to give Fizz a bit more flexibility in the lane especially when he's on the back foot and forced to just last hit minions. To top it all off, we're exploring cool ways of further pushing Fizz's unique identity as the Assassin with strong initiation potential.
One of Kha'Zix's core tenets is to evolve and adapt - we want Kha'Zix players to feel like they are constantly re-considering which evolutions to take based on the context of the current game as well as their own playstyle. And although we want to continue to keep Isolation as the way Kha'Zix primarily succeeds, we are taking this opportunity to limit his instant burst damage and empower him to utilize the tools he has to follow-up and finish his victims.
Although we think Shaco is ultimately in need a full VGU-esque update, we wanted to take some time to give him a quick tune up. We want to give him back some of the cool tricks he used to have (as well as some new ones), but at the same time address some of the long-term game health issues he has always presented (overbearing early ganks and relentless split pushing).
Although an already solid part of the roster, Zed can be an overly generalist choice in the Assassin space due to his relatively safe early game and his effective Assassination tools. Outside of some tuning adjustments, we're looking for some interesting ways to make Zed think more carefully about the opposing team composition and in particular who he chooses to Death Mark throughout the game.
The assassin update will be a part of the preseason, which you can expect shortly after the season ends November 6.


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Low price Aquatic Weed Cutting Machine River Cleaning Boat Water Grass Harvester for Sale
|Weed Harvester
|Size (L*W*H)
|7x2.3x1.6 m
|10.5*4.2*2.5 m
|12*4.4*2.7 m
|15*4.5*2.7 m
|17*4.5*4 m
|Cutting Width (m)
|1.2 m
|Cutting Depth (m)
|0.5 m
|Draft (m)
|0.4-0.5 m
|0.4-0.5 m
|0.4-0.5 m
|0.4-0.5 m
|0.4-0.5 m
|Discharge Height (m)
|1.5 m
|2.5 m
|2.5 m
|2.5 m
|2.5 m
|Driven Type
|Paddle wheel
|Paddle wheel
|Paddle wheel
|Paddle wheel
|Paddle wheel
|Control System
|Semi Automatic
|Full Hydraulic
|Full Hydraulic
|Full Hydraulic
|Full Hydraulic
Brief Introduction:
Full automatic Aquatic weed harvesting equipment is used for collecting the floating rubbish, cutting aquatic plants, kill water weed in reservoirs, rivers and lakes.
The Aquatic weed harvesting equipment is designed for easy operation.
All the collecting,stocking and transporting device can be completed by one man via operating the control desk.
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One of the Best Italian Restaurants in New York
Michael's of Brooklyn has been satisfying hungry customers in Brooklyn, New York, since 1964. Serving Italian recipes that have been passed down for generations has made this local, family-owned restaurant a national favorite in Italian-American cuisine. Food Network even named Michael's Veal Parmigiana one of the top five Italian foods in America! It's safe to say that Michael's of Brooklyn is one of the best Italian restaurants in New York and beyond.
Types of Pasta Sauce
People come from all over the country to dine at Michael's of Brooklyn's famous restaurant, but for those who can't make the trip, the owners decided to bottle and sell their homemade pasta sauces. At Supermarket Italy, you can find traditional types of tomato pasta sauce with exceptional flavor, including the brand's Home Style Gravy, Puttanesca, and Tomato & Basil. For a spicier pasta dish, choose Michael's of Brooklyn's Arrabbiata. And if you're looking for a classic, there's nothing better than pasta with marinara sauce!


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COVID-19 has imposed several restrictions, particularly on movements that have affected our daily routine. Specifically, our seniors have been confined to their four walls with minimal physical exercise. Excellent physical health leads to excellent mental health. Hence, we need to encourage our seniors to get the extra energy doses their body well deserves!
According to CDC, an average adult needs 150 minutes of moderate exercise or 75 mins of Vigorous exercise weekly. However, with age, some of us may find it challenging to cope with these requirements, and therefore, it is essential for us to begin with our baby steps towards fitness.
In this article, we discuss Six simple indoor exercises to keep our seniors fit and healthy.
Walk, Walk And Walk
Walking is an excellent form of physical activity that doesn't need much effort. It involves coordination from your brain's cortical motor regions and muscular areas to execute the walking actions. It does not require gym subscriptions or well-maintained walking tracks. Walking 45 mins a day can help you eliminate all the toxicants your body was jammed with. You could purchase a treadmill or watch videos that portray the correct forms of a walk. It signals to your brain that some activity is being carried over, and hence it needs to be alert! You can also make use of the staircase- walk up and down as many times as possible. If you reside in a flat, try using the stairs instead of the elevator at times. Daily lifestyle changes, such as walking to the grocery store or beach walks, should be encouraged.
Household Chores And Gardening
Yes! It's indeed the right time for you to clear your closet or to dust out the corners of your house. While you perform these chores, you unknowingly make physical movements by bending, stretching, walking, and jumping (if this includes dusting your roof). Exercises are very much essential as we age. Your body needs physical activity and rest, and hence it is our utmost duty to nourish it with both aspects.
Gardening is another exciting activity that serves two purposes; it nurtures your garden and keeps it healthy. While you are busy working, it lets you get rid of all the unwanted tensions you have in your mind and the physical movements that you make. Studies have suggested flowers and plants uplift an individual's mood. And in such circumstances, it is the purest form of boosting our confidence in the most natural way.
Sit And Stand Chair Exercise
As we age, normal functions like standing after sitting, initiating movements can be challenging. These minute situations sometimes drain our confidence around people.
All you gotta do is grab on a sturdy chair. Make sure to support it against a wall to maintain its balance while you exercise. Now gently sit and while you rise, with a firm grip, balance your body well and sit again. Continue with this activity for some time until you are done for the day. This training can also be included as a warm-up exercise for the seniors as they begin their routine activity.
Stationary Bicycling
Riding a stationary bicycle boosts your cardio stamina. Cardiac aerobic workouts such as cycling, running strengthen the vital organs, including the heart, lungs, and muscles. It can also help you lose weight by burning some of your body fat. Apart from these positives, it also strengthens your core and limb muscles, along with an increase in stamina. You can always purchase a stationary bicycle or maybe recycle one of your old bikes to make things work for you. Start pedaling for 10 minutes initially and then increase as you practice every day.
The Essence Of Physical Exercise And Meditation- Yoga
Yoga is an age-old exercise that keeps your mind and bodywork in synergy towards achieving fitness. It is a set of physical activities that, along with breathing techniques, can help individuals aiming to stay fit and individuals who suffer from respiratory issues such as asthma.
Listed below are a few asanas (poses) that will give you the essence of yoga.
Being a beginner, do not overexert yourself. The goal is to be calm and let your body reach out to the different lengths of flexibility as it can.
Tree Pose
A tree symbolizes the life that maintains a balance between its roots, branches, leaves, and the fruits it bears. This pose helps you improve your body balance and enables you to keep your body stature.
Step 1: stand straight and join your hands.
Step 2: gently lift your left foot and support it to your right thigh.
Step 3: as you maintain this posture, gently breathe in and out.
Note: Not to be performed on days suffering from blood pressure or balancing problems.
Cobra Pose
An excellent pose to strengthen your neck and spinal muscles. It also increases your back flexibility and stretches your abdomen as well as your forearms.
Step 1: lie on the floor with your palms facing the ground.
Step 2: raise the upper half of your body and focus your gaze above on the roof.
Step 3: Remain in this posture for 20-30 secs as a beginner.
Note: Not to be performed if having neck or back problems such as arthritis or vertebral column injuries.
Child's Pose
Remember being a kid and having no things to worry about?
Yes, this pose helps you revive your childish postures and retrospection the various unwanted thoughts occurring in your mind at the movement.
Step 1: gently kneel on the floor, and let your feet stretch flat on the ground.
Step 2: raise your hands straight and bow down until you reach the ground.
Step 3: push your core towards your thighs. Be mindful of your breathing.
Note: do not perform if any you have knee or ankle injuries.
Corpse Pose
Most of the asanas end with this pose to help you breathe and get your focus back into the current situation. After stretching minutes, you need to ensure a good flow of oxygen through every inch of your body. This pose helps you relax with some soothing background music of your choice to get into a refreshing mood.
Step 1: lay down on the floor.
Step 2: maintain a straight body posture and get back on your feet after minutes of relaxation.
Plank Pose
Plank is one of the core strengthening exercises most commonly used. Being a part of modern yoga boots your abdominal as well as butt muscles.
Step 1: place your elbows below your shoulders.
Step 2: move your body above the floor by gently exerting pressure on your forearms and toes.
Step 3: Remain in this posture for around 30 seconds.
Note: should not be performed if suffering from shoulder or ankle issues.
Let's Dance
Dance is the purest form of physical exercise that gets you into the mood. Be it a junior or senior, and it's an expression of happiness and enthusiasm. You can play some music of your choice and let your body dance to the tunes of your soul. Freeform or choreographed, there is a constant firing of various nerve impulses in your brain. While being in a digitally modern era, you can use social media platforms to learn multiple dance forms or practice while watching an online video.
Zumba and aerobics are other forms of an exercise regimen that incorporate physical exercise as well as dance. They aim to strengthen your core, provide physical fitness, and eliminate unwanted toxicants in the form of sweat. However, it is advisable to perform these regiments under the guidance of a trained and certified instructor.


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Mehta, Vikram; Price, Blaine; Bandara, Arosha and Nuseibeh, Bashar
DOI: https://doi.org/10.1145/2968219.2979138
Physical or bodily privacy is an innate need that drives a variety of human behaviours. However, in a highly dynamic, crowded and context dependent world with rapidly changing technology, other humans or technological devices can pose threats to the physical privacy of an individual in many ways. This short paper explores the use of wearable devices to tackle this multi-faceted problem.
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Funded Project Name Project ID Funding Body ASAP 291652 ERC Privacy Dynamics: Learning from the wisdom of groups (XC-12-062-BN) EP/K033522/1 EPSRC (Engineering and Physical Sciences Research Council) Not Set 13/RC/2094 SFI
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A Swiss Army Knife for Minimax Optimal Transport
Proceedings of the 37th International Conference on Machine Learning, PMLR 119:2504-2513, 2020.
The Optimal transport (OT) problem and its associated Wasserstein distance have recently become a topic of great interest in the machine learning community. However, the underlying optimization problem is known to have two major restrictions: (i) it largely depends on the choice of the cost function and (ii) its sample complexity scales exponentially with the dimension. In this paper, we propose a general formulation of a minimax OT problem that can tackle these restrictions by jointly optimizing the cost matrix and the transport plan, allowing us to define a robust distance between distributions. We propose to use a cutting-set method to solve this general problem and show its links and advantages compared to other existing minimax OT approaches. Additionally, we use this method to define a notion of stability allowing us to select the most robust cost matrix. Finally, we provide an experimental study highlighting the efficiency of our approach.


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Chimney Mountain
Chimney Mountain, a 2.5 mile out and back trail, is a unique climb in the Indian Lake region that offers beautiful perspectives on the surrounding land, including King's Flow. Please note that the trailhead is on private property, so mind the $2 parking fee and stay on the path. Starting off with gently rolling terrain, the path turns steeper as your draw near the summit. Toward the top and when the trail levels out, there is a spur path that heads to the distinctive rock formations that give Chimney Mountain its name. From the chimney rock to the system of caves and rock crevasses, there are plenty of neat spots to explore along the trail! Not far beyond the chimney formations, the official summit rising at 2,700 ft above sea level provides beautiful 360 degree views of the central Adirondacks.


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Hatifi high school is one of the most popular schools in Herat that is going on in four shifts. Hatifi high schools have an IT Class which is mobilized with computers. The IT Class is mobilized by Citadel Company and helps the students to get on the internet and social media.
The students, who are active in Film Annex, are writing film treatments. The students who passed the training course are now writing blogs to express their ideas and opinions.
The winter course is going on by Citadel Company in the school, and a lot of students are attending in. A company held a course for the students from seven to twelfth classes to improve the students' ideas.
Besides, working in social media by the students is very active in the internet. The students are getting training in mathematics, physics, chemistry and other subjects. Fortunately, the students' educational level is increasing.


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- DLサイズ 579 MB (607,389,643 byte)
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All sounds included in this sample library ("Sounds") remain the property of its manufacturer and/or Crypton Future Media, Inc.(collectively, "Licensor").
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'Unstoppable Pop' is the newest loop product from top sample label Strategic Audio. Pop music has grown and evolved to encompass too many styles to number, from the purely live sounding to the EDM sound now controlling the club scene. These Construction Kits here are inspired by the music of Billboard-topping artists in mainstream Pop such as John Newman, Zedd, Naughty Boy, Capital Cities and OneRepublic.
Get the sound that's currently dominating the charts worldwide!
Packed with over 560MB of bright piano chords, big drums, smooth basslines, rich strings, lush synths and leads, this kit is a must have for today's producer/beatmaker.
All sounds have been processed by the latest top of the line Waves plug-ins for that album and radio-ready sound.
This product includes ACIDized WAVs at 24-Bit, 44.1kHz quality, either as perfect loops or one-shot files which allow the tails of reverbs and delays at the end.
(From STRATEGIC AUDIO)
*This description is a reference taken from the original developer's website.
- About KONTAKT format: Please note that this product is not compatible with Kontakt Player, and requires the retail version of Kontakt to work. This product will not appear in the Kontakt libraries pane.
- Attention: Hard disk must be in the following format: HFS or NTFS +
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"One in three young people living in cities thinks it is acceptable to carry a knife in self-defence because violence is so rife, according to research revealed today. Teenagers and twenty-somethings have lost faith in politicians, the police or schools to protect them and increasingly believe they need to be armed to defend themselves against people of their own age. Nearly half said they knew someone who had been a victim of knife crime."
The Guardian, 18th May 2008
Source: www.guardian.co.uk


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Minister Jan O'Sullivan announces feasibility study23/11/11
The Minister of State for Trade and Development, Jan O'Sullivan T.D., today announced that the Department of Foreign Affairs and Trade has tendered for a feasibility study on the development of a humanitarian hub at Shannon Airport. Minister O'Sullivan said:
"We will be seeking tenders from suitably qualified individuals or companies to assess the overall viability of developing humanitarian facilities at Shannon and the potential level of demand from other Government aid agencies, the UN, the Red Cross and Irish and international NGOs."
"Proposals for the development of a humanitarian hub at Shannon are primarily being considered against the backdrop of the existing international humanitarian system, the UN Humanitarian Relief Depot. The key is to identify how Shannon can add to this system and with this in mind I have decided to carry out a feasibility study to examine some of the ideas involved."
In addition to engaging with Irish Aid and potential users of a hub by the humanitarian community, the study will also involve consultations with the Shannon Airport Authority, Shannon Development, the Mid-West Regional Authority, other relevant local authorities as well as representatives of the private sector in the Shannon region. Minister O'Sullivan said:
"Ultimately, like many in the Shannon region, I would be very keen to see the development of a humanitarian hub at the airport. In commissioning this independent study, I am conscious of the need to ensure there is a strong business case to take this initiative forward and to ensure that any initiative offers value for money, as well as having a positive impact on the existing international humanitarian system".
Contact Details
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Tel: +353 (0)1 408 2280


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Makeup Creations Brow Powder Trio is a three-pan compact that allows you to custom-blend a precise shade that works best to create naturally, beautiful eyebrows. Shades can be used individually or blended together for the perfect shade! Great pigment and easy to blend colors.
Color Information
While MakeupCreations.com has tried to accurately display the colors of products, the actual colors you see will depend on your monitor and may not be accurate.
Final Sale
All cosmetics are FINAL SALE and not eligible for return except in cases of manufacturing defect.


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October 18, 2021 – Reading time: 10 minutes
Keeping up high development speed, reducing bugs and creating maintainable/reusable code – If these are your goals, 'code quality' should be your focus.
You probably know projects that push for feature completion and are struggling with bugs, defects and performance issues. This is what a lot of software projects look like.
Having seen numerous projects and watching the same pattern repeating over and over again, one significant issue is the separation of development and quality control – either in time, in space, or both.
Practices that increase software quality
Technically software quality defines all desirable attributes of a software product. For embedded solutions these are most notably: Performance Efficiency, Reliability, Reusability, Maintainability and Size.
Performance Efficiency & Size
The performance and ROM size of the hardware are always a significant bottle neck in embedded project. So it is unsurprising that optimizing for those is common even in early stages of embedded projects.
"Premature optimization is the root of all evil in programming."
– Donal Knuth, The Art of Programming
Everything includes a trade-off. The trade-off of optimizing performance is less reusable and less maintainable code. Performance optimization lowers readability, testability and usability – the most critical qualities in projects that experience a lot of change. Additionally, it is more difficult to identify deficiencies in code that is optimized for performance rather than readability.
"There are two ways of constructing a software design. One way is to make it so simple that there are obviously no deficiencies. And the other way is to make it so complicated that there are no obvious deficiencies."
— C.A.R. Hoare
Effective measures to improve Performance
- Champion regular performance testing from early in the project
- Risks can only be managed when measured
- Focus development on readability and testability
- The development today should not be allowed to compromise development tomorrow
- Create performance unit tests for all critical units
Reliability & Maintainability
"There is no glory in prevention."
― unknown
Although reliability, correctness and defect minimization are goals of customers and users, a culture of defect prevention is as rare as they come. What can be found in most projects are economies of defects. QA is praised for finding them and developers are praised for fixing them. Because bugs are usually important and urgent, the fixes are often rushed, repeating the 'quick and dirty' practices that created them in the first place.
"The ratio of time spent reading versus writing is well over 10 to 1. We are constantly reading old code as part of the effort to write new code. Making it easy to read makes it easier to write."
― Robert C. Martin, Clean Code: A Handbook of Agile Software Craftsmanship
The efficiency of writing code is greatly depending on developers being able to understand and reason about the code. Readability alone has obviously a tremendous impact on code comprehensibility and yet is blatantly absent in most projects. Though complexity is known to have a significant baring on every aspect of software quality, it is harder to teach and treat. Prioritizing readability and testability over simplicity allows to more easily identify and address complexity. Increasing readability and testability will inadvertently make code simpler without addressing complexity directly.
Effective measures to increase Reliability and Maintainability
- Champion unit testing and static code analysis
- Focus development on readability and testability
- software reflects the understanding of the developer.
- Make automated unit tests and readability checks a critical part of pull requests
- Praise defect free code and offer coachings to developers that produce defects
Most companies are building their business case on the assumption that code will be reused for similar projects. While new projects are often built on previous projects and code is reused regularly, the benefits are significantly less than what might be expected. It is common that every part of the software is adapted, reworked or even replaced for any new project. This is not only true for what is considered to be the 'application', but for the base software, too.
"A good design is not the one that correctly predicts the future,
it's one that makes adapting to the future affordable."
— Venkat Subramaniam
Reusability is by far the most complex software qualities. It requires two levels to design reusable code. The first level – the prerequisite level – requires a simple and clear architecture, reasonable code and documentation. Without the first level it is only possible to incidentally write reusable software. The second level – the reusability design level – requires transparent variant management, insights into requirements similarities and differences in several different projects, good abstractions, appropriate generalizations and awareness of the stakeholders and their needs. Most companies struggle with the reusability of their software because they skip the prerequisite level. The clarity created on the first level is needed for a proper analysis and design of reusability. Investing in that clarity will improve the degree of reuse and accelerate new projects.
"Always design a thing by considering it in its next larger context."
– Eliel Saarinen
Effective measures to increase Reusability
- Champion transparent and simple design
- Such a design should be easy to find
- Each diagram should describe the context
- Everything should be comprehensible without explanations
- Focus development on Readability and Testability
- providing safeguards for developers to reuse code will make it significant more likely that they will
- Make design reviews a prerequisite for implementation
Accelerate your development today and tomorrow
Cost and deadlines are the common arguments to shy away from software quality and go for the quick and dirty hack. Yet, improving your companies, your departments, your teams, your personal software quality practices, is very likely to break even on the first project. The real reason – it seems – is neither cost nor deadlines: It is the learning and the change that is required to write better software. It is our human nature to focus on the short term that leads us to choose the stress tomorrow over the pain of change today.
The focus on the two qualities 'readability' and 'testability' will allow you to start and improve your journey to software quality with to simple steps. The benefits of readability are worth the effort from day one. Be it in design or in code. This fundamental quality will increase your co-workers and your own satisfaction and productivity. The second step – testability – is more difficult, but well worth the time and effort. Testability reduces stress and soon you do not want to development without the ease of mind that the 'compile, test, commit'-cycle provides.
With these two qualities, the challenges of software quality will be significantly reduced.
May your next feature be bug-free.
- INVENSITY Center of Excellence Software Engineering
- Core Competences
- Architecture for Legacy Code
- Staged Continuous Integration
- Continuous Integration
- Core Competences


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Interest is a financial fee for borrowing a set amount of money. This is the amount of money that a borrower owes a financial institution for borrowing them money. It is typically calculated as an annual percentage rate figure also known as (APR).
This rate can be impacted by inflation rate, amount of time that the money is borrowed from a lender, liquidity, and risk of default. Interest can express a person or stockholders ownership percentage in a corporation with a set percentage that may vary.
How Does Interest Work?
There are two different common types of interest which include simple and compound interest. Each of these types can be applied to various loans and affect the amount of money the borrower would pay back.
When you are calculating interest, there can be a number of factors to consider. With interest you will have to measure the amount of inflation that may affect the amount that is owed back. The rate of inflation and interest rates have an inverse relationship.
Inflation refers to the rate in which the price of goods will increase. For example, when interest rates are high the economy is more sluggish and inflation tends to decrease.
Additionally, borrowers need to be aware of the potential risk that have if they default on the loan. Defaults can lower your credit score which will make it more difficult to get approved for another loan in the future. They also can affect secured debt, such mortgages, which are backed by collaterals. If the borrower defaults, then the bank will be able to seize their collateral to pay off your loan.
How Do I Earn Interest?
You will earn interest whenever you lend money or put funds inside of an interest-bearing bank account. When you have money saved up you earn interest from it by letting it sit in your bank account.
Banks will offer low rates to encourage people to lower borrowing costs to increase spending amounts. Using high interest accounts is a great way to earn profit.
Online banks tend to have lower costs and offer very high interest rates. Whether as, traditional banks are very different and typically have lower rates that you can't benefit from as much.
Annual Percentage Rate (APR)
An Annual Percentage Rate would be your interest rate that is set as a yearly rate. Borrowers look at their APR so they have a good idea of how much they have to pay for the loan.
With fixed APR, it does not change during the timeline of the loan. Fixed APRs are more predictable and they would include things such as mortgages and personal loans.
In comparison, variable APRs are tied to an index interest rate and can fluctuate over time. These are more unpredictable and they will increase as interest goes up.
Types of Interest
There are various types of interest that you need to be aware of prior to borrowing or taking out any loans.
Simple interest calculate the principal portion of a loan. How one would do this is by following this formula:
Simple Interest = (P * R * T)/100
P = Principal amount
R = Rate of interest
T = Number of Periods
This form of calculating interest is usually used for short-term loans or easy calculations. They are generally used in single-period settings since they can be inaccurate for longer term loans.
Compounding interest is essentially the interest you gain from your interest. To determine the returns this calculation considers the initial deposit, contributions, time span, rate of return and the compound frequency of a loan.
The formula consists of:
Compound Interest = P * (1+ (R/N)) ^ N*T
P = Principal balance
R = Interest rate
N = Number of periods interest is applied
T = Number of periods
This form of interest is used to grow your savings over time. This is because interest continues to accrue and get added into your account over time.
You can leave money in the stock market to allow your returns to grow over time. But, they can lose value over time if the stock is performing poorly.
Accrued interest is the amount that is incurred over a period of time that has to be paid back. It is the amount of bond interest that has built up over time since the borrower last made a bond interest payment.
Its formula consists of:
Accrued Interest = FV * (R/365) * N
FV = Face Value
R = Coupon rate
N = Accrual period
Accrued interest can build up for either a borrower or a lender. At the end of an accounting period, accrue interest will be noted on the following pay period because it has yet to be paid back.
Learning More About Interest
Interest is the fee for borrowing a set amount of money. The most common types of interest included simple, accrued, and compounding.
Financial advisors can help you understand how to take advantage of interest rates and save up your money quickly. You should think about consulting a financial advisor to help you build your wealth and plan for the future.