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By Carolyn Milburn
Originally posted May 19 2001.
Antisocial teenagers tend to have parents who are harsh, inconsistent disciplinarians, according to a study examining links between parenting styles and teen problems.
Teens who stole, got into fights, drove cars without permission and committed other rebellious acts had parents who used similar, but ineffective parenting style.
Compared with problem-free teens, antisocial adolescents were more likely to have parents who shouted at them and lost their temper when the teenager was rude.
The parents' disciplinary methods depended on the mood they were in. And they did not monitor their children's activities as closely as parents whose children did not have behavior disorders.
The survey, by the Australian Institute of Family Studies, also examined depression among teens and possible links to parenting styles.
It found relationships between depressed teens and their parents were less warm and of poorer quality than the relationships between problem-free teens and their parents.
Depressed adolescents felt more alienated from their parents and communication between parent and child was not as open.
The study involved a survey of 73 anti-social teens, 74 depressed adolescents, 64 problem-free teens and their parents.
As part of the survey parents were asked to describe their parenting style. Each parent and child was also filmed discussing issues and solving problems.
One of the study's authors, Diana Smart, said that although parenting style contributed to a child's behavior, other influences such as peers, school, and the child's temperament also played a significant role.
"The study is not showing that parents are bad parents," Mrs Smart said. "It shows that some parents are less effective in their parenting style.
"It can be difficult being a parent of a teenager. It can be hard trying to be consistent, trying to maintain rules and standards when a teenager may be narky, trying to avoid extreme responses when you're being provoked," she said.
"But nevertheless, it's worth the effort because what parents do can facilitate good development in their children."
Adolescents without behavior problems had warm, close relationships with their parents. Their parents monitored their activities and knew what was going on in their children's lives.
Mrs Smart, a senior research officer at the institute, welcomed a recent Federal Government initiative, the Stronger Families and Communities Strategy, which is a series of nationwide programs to help parents improve their parenting skills.Copyright © The Age Company Ltd 2001. Any unauthorized use, copying or mirroring is prohibited.


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subset: commoncrawl


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Mykell Bates
Mykell grew up in Roseville, CA. Mykell played for the U17 and U20 U.S. Men's National teams, and lists competing in the U17 World Cup qualifiers in Jamaica and playing in the U17 World Cup in South Korea as his favorite soccer memories.
Mykell played collegiate soccer at Santa Clara University and is now the Assistant Coach for the Santa Clara men's soccer team. Mykell played professionally for the Toronto FC MLS team.
One of Mykell's favorite parts about coaching is having a part in (and getting to witness) player growth, both on and off the field. The other piece he enjoys is the competition side of the game, the coach way. Mykell feels competing as a coach is similar to chess, as a coach is constantly analyzing the obvious and even the small nuances. Mykell says it can be hard and stressful at times but when it's done right, the feeling is unmatched.
Mykell credits a conversation he once had with MVLA's Technical Director Albertin Montoya for helping bring clarity to his own coaching goals. Albertin told him that the growth you see in your team from your guidance is the true feeling of success. Since Mykell has taken on that mindset, he says that seeing the growth of his players and team not only feels like success, it brings a feeling inside of happiness!
Mykell's favorite player is Michael Essien. Mykell loves spending quality time with loved ones (when time permits), seeing/hanging with his dogs, and watching basketball.


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European Union recognises Engro Foods' Dairy Development Program Jean Francois Cautain visited Engro Foods beneficiary trainees in Karachi
European Union ambassador to Pakistan, Jean Francois Cautain visited Engro Foods (EFL) beneficiary trainees working as dairy farm supervisor at farms in Karachi. The ambassador appreciated EFL's efforts for creating skilled workforce to support the dairy value chain. European Union also circulated a short video about this Dairy Development Program on their official social media platforms commending Engro Foods role for dairy development to strengthen the local farming community. Engro Foods is cultivating prosperity by providing trainings on best dairy farming practices to create sustainable livelihoods through increased income for farmers. Engro Foods has trained 1,263 skilled manpower in total, 35% of them being women. This Dairy Development Program was funded by European Union (EU), Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) and Norwegian government through National Vocational and Technical Training Commission (NAVTTC) Sindh Pakistan. At the visit, the EU ambassador also awarded certificates to qualified farm supervisors and female livestock extension workers. Saud Ahmed Pasha stated, "Our purpose, our plan is to revolutionize the dairy sector of Pakistan and it feels great to have our Dairy Development Program (DDP) recognized by independent international bodies such as European Union. The work that is being done with the farmers will empower them with sustainable livelihoods– in the context of this project, EFL has managed to train 1,260+ beneficiaries as farm supervisors, 448 of them are women. Currently 80% of these farm supervisors are employed at commercial dairy farms and others have started their own micro enterprise. The trained workforce has also resulted in increasing the overall farm productivity by 22% which is notable increase in the dairy sector." Engro Foods is owned by 19,000 dairy farmers globally and they are determined to strengthen the local farming communities in line with their core purpose of enabling a better living for our farmers, now and for generations to come.


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text: Email Scam AuthorSusan Tanner / Posted onJune 29, 2022June 29, 2022Leave a comment Be aware if you get an email from Cindy Scott, Kyle E. Sims, or other Synod officers. Please double-check and make sure it is from a recognizable email and not a scammer before you open any attachments. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Like this:Like Loading... Related


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29/03/2022 – For metal wires, wire ropes and wire derivatives manufacturers
Shears, welding machines, coil lifting systems and more
The shears line offers a full range of portable tools for cutting, straightening or bending of metal wire, allowing a fast and effective solution to the problems related to wire, cable, strand and bolts and nuts.
With light and portable tools from Tramev Shears Division, to cut, to cut off, to bend, to straighten is now a very easy operation. Shears for wire and cable are without a doubt the most successful product made in Tramev. However over the years Tramev developed with customers and suppliers other equipments to resolve common problems that are created along the chain of production of wire and cable.
Some solutions (such as the gripper for handling of coils and bobbins ) allow an enormous saving in terms of time, others as the strapping rubber tube involved in the final stage of the manufacturing process and help to prevent damage to the finished product.
Tramev will be showing its products at "wire". Here some previews:
– new battery and portable shears, provided with a 360° rotating head, engineered for both wire and cable
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– clamps for coil and bobbins lifting up to 4t
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Tramev proposes itself to the metal wires, wire ropes and wire derivatives manufacturers, both as a supplier of new standard or special accessories and as partner for the solution of technical problems, with the policy of partnership needed to reach, together with the customer, the qualitative and quantitative enhancement of the production.
Tramev SRL
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Search Results
Watoga Emergency Services
|Cranberry Bog
Watoga Emergency Services is one of the Locations within the Cranberry Bog region in Fallout 76 (FO76). Players can access locations by progressing in the game's story and as part of Side Quests. Some Locations are seemingly inconsequential, but can reward players with special Equipment and Items.
Watoga Emergency Services is a location within the Cranberry Bog that acted as a hospital for the Brotherhood of Steel after they established themselves in Appalachia.
Quests in Watoga Emergency Services
The following quests are related to this location
- Daily: Cop a Squatter
Enemies in Watoga Emergency Services
The following Enemies inhabit this location
Resources in Watoga Emergency Services
These notable Equipment & Resources can be found at this location:
- Power Armor Spawn
- A fallen Brotherhood of Steel soldier, inside the locked laboratory (interior).
- On the roof (exterior), between barrels and crates, around the corner (to the right) from the elevator.
- Bobbleheads, Magazines
Notes & tips
- __notes__
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Camilla and Susanne are members of the Strengthening Music in Society project of the AEC (Association Européenne des Conservatoires, Académies de Musique et Musikhochschulen). Camilla recently obtained her master's degree from the Royal Academy of Music in Aarhus in pop/jazz guitar, while Susanne has had many years of experience working in education after a very satisfying career as a classical musician.
They were interviewed via e-mail by Brandon Farnsworth and Rosanna Lovell of GRiNM in response to their manifesto for the future of music education.
How do the practices and continuities in music education from early learning through to university level shape the music scene of performers, composers, etc., that we see today? And in considering this, how could we see the field of education as a site for radical change with the possibility for lasting impacts in the music we see performed?
Susanne van Els (SvE): Classical music education is built on (early) specialised training. Talent is mostly defined as a given physical and mental condition, and qualities like resilience and persistence are used in the context of technical achievement. Having a musical soul and a deep creative connection with the mystery of classical music, and developing knowledge and understanding is, of course, not just helpful but essential in the long process of mastering an instrument, but in music education this seldom manifests into a meaningful connection. It is such a pity when there is a lack of creativity and contemporaneity in classical music education. For musicians, for audiences, for music itself. The remedy is to change the balance from re-production to making, also within the setting of a conventional classical concert.
All art is contemporary. Music, which is defined by time—real time, the here and now versus as well as united with eternity—is extremely contemporary; Beethoven's 9th is different every time it has been performed over the past 200 years. All art is both a confrontation and unification of the individual with the collective. When listening to Bach's St Matthew Passion, a piece almost 300 years old, the deepest individual pain and joy are perceived in an awareness of collective human connection. Therefore, all art is societal.
Camilla Overgaard (CO): The wide variety of different practices within music education undoubtedly shape the multiple existing music scenes in many different ways. More concretely, I believe that the master-apprentice model, which has been and to a large extent still is very dominant within music education, shapes performers especially. The idea of studying with a master to one day eventually become one yourself, can in my opinion be quite repetitive and thereby potentially influence the image of what a musician is in the music scene as well. The opposite could of course also be true, if practices within music education encouraged diversity and ownership amongst musicians from early learning through to university level.
By articulating and nuancing the stereotypical and often hierarchical image of what it means to be a musician, I believe that the field of education can catalyse change in the music we see performed—and more importantly, who feels they can/have the right to perform it.
How do conservatories and music schools need to be organised in order to foster musical diversity? What structures are needed, and what are the biggest challenges faced in realising them?
SvE: Structures are important, but mindset is key. However, one remark about structures: when designing curricula, programs, courses, pedagogic approaches, etc., without changing assessment—for both entrance and graduation—accordingly and fundamentally, nothing happens.
I see a conservatoire as a learning community: students, teachers, staff, visitors, audience, and professional partners meet in order to learn, both individually and collectively. A conservatoire is an institute for learning, but it could also see itself as a place of learning: anyone entering the building should take on a curious, open attitude. Everyone is continually developing, and together we develop the profession and our artform. The concept of a learning community is helpful in contextualising the master-apprentice model, which is a very valuable asset in music training. One of the blind spots in most classical music education is that it is so focused on the individual, whereas the job is collaborative—and a general misconception is the idea of the 'audience' as passive consumers instead of the community that we, musicians, are part of, both while performing and creating. A change in mindset that would foster diversity is to see students as active, researching artists. It would give them agency over what they do and keep them connected with why they want to do it. This could change conventional approaches towards ideals, which in classical music are quite hierarchical and heroic. Students need to be given broad options to choose from, not just in the study programme, but also regarding assessment, because they are working towards what success is to them.
CO: In order to foster musical diversity in conservatoires and music schools, I believe it is important that diversity is embedded at all levels within the institution. In my opinion, diversity in music originates from diversity of people, and therefore it is important that conservatories become accessible to a broader range of people. Becoming more accessible is challenging, since it means that existing structures inevitably have to change in order to embrace different kinds of musicians—an example could be changing the entrance exams or assessment criteria at conservatoires. This would very likely lead to a discussion of what or who defines quality, when the goal is musical diversity. How diverse do we really want it to be? How much are we ready to change?
I also want to emphasise the importance of giving students the possibility to choose part of their curriculum themselves. Musical diversity is also fostered by encouraging students to be curious and to expand their musicianship in new ways, for instance, by taking subjects from other departments.
Susanne, how do you help students free their thinking like this? What do you think needs to happen in conservatoires to foster this kind of approach? What kinds of new narratives and images do we need to present in music education?
SvE: Realigning the art of classical music-making towards the component of making, from juvenile training and during the 10,000 hours, is essential. This will keep young musicians connected to their creative side, and it will most likely encourage them to retain a broad scope. Range, which is part of divergent thinking and interdisciplinary work, is essential when working in the contemporary world, and for musicians this means being able to connect and to collaborate whilst also being specialised. One of the most important qualities for teachers is generosity. Inviting students to not just become better than them, but to also be different. Encouragement is a tool from parenting that is most welcome in teaching as well—being there. Process over progress, with 'joy and belonging' being keywords for everyone involved. Teachers are active, researching artists, too, and together with students they shape the learning community. Interestingly, narratives of great musicianship are all around us, in real life; for example, Yo-Yo Ma says about learning to improvise while connecting musicians from East and West: "Perfection is not very communicative." Fighting conventional archaic, male images in classical music means replacing internalised stories of individual heroism with real life stories about companionship and citizenship.
Camilla, what has this process been for you as a student? What struggles have you faced while pursuing your interests in the conservatoire setting? What kinds of new narratives and images do we need to present in music education?
CO: Firstly, my path at the conservatoire has been a winding road. My bachelor's degree is in music education with classical guitar as my main instrument, whereas my master's degree is in pop/jazz guitar and song writing. This journey has involved a lot of frustration and a feeling of not really fitting in anywhere, although despite this it has also kept me searching for new possibilities. In hindsight, I think it is because I do not define myself as either a classical or pop/jazz guitarist—I am somewhere in-between the two, and I have found this mixed identity quite difficult to develop in the conservatoire setting. The challenge for me has been having my musicianship split into categories by subjects and departments. To some degree, this is necessary to structure an education programme, but the negative consequence is that we might get stuck inside these categories and not work across or between them. A classical guitarist is considered one thing and a pop/jazz guitarist another, and to some extent this is true, but to me this does not help build an artistic identity. I believe that artistic identity originates from why we do what we do, is expressed in how we are doing it and eventually manifested in what we do. The focus is often only on the what in the conservatoire setting. This led me to search for my what when I should have been searching for my why. If we shift the focus in music education from what to why, I believe that new narratives and images will emerge.
We are starting to see some really interesting thinking and research about many longstanding issues in the conservatoire. How do you imagine a closer interaction between fields of practical (instrumental) and academic (research) study in music departments at universities?
SvE: Similar to most structures, conservatoires seem to be not very receptive to change. Every now and then I find myself with colleagues saying, "If we could start a new school now…," and our dream expresses the same kind of freedom that can be experienced in a jam session. The only answer that I can think of, both for this situation and to the question, has to do with connection. Academic subjects could have a large practical component, and the reflective, researching part of the main subject area could have more exposure. Quality assurance outcomes could be discussed together with all stakeholders. Transparency is a great connector: Why could students not be given an insight into institutional financial decisions? What if we acknowledge that students understanding how they are being graded is an important factor in learning? Is it really effective that students only work in cohorts that are arranged by levels? What I am trying to say is that binary or hierarchical thinking is not helpful, and that the only way to connect valuable insights, wonderful people, and different perspectives is through practical daily practice, on the floor. Just do it.
CO: The very first thought that comes to my mind is that it may be beneficial to imagine a closer interaction between people first and fields second. Approaching the question from this angle, I would suggest that a way to enhance interaction could be by developing collaborative projects out of common ground. When different fields are compared or discussed, naturally the focus tends to be on their differences rather than their commonalities. Shifting the focus to these commonalities could potentially help to create this common ground and thereby foster interaction between people from different fields of study. Ultimately, interaction is about sharing knowledge, and I believe that this is done best when people create something together. This is why I imagine that developing collaborative projects with a very hands-on approach could be a way to foster interaction.
Thinking of what we have been discussing so far regarding diversification and intervention in the conservatoire, can you briefly state your vision for the future of the conservatory system in Europe? Where does this take us as classical music creators and educators?
SvE: I have seen how students take on the challenge of quality learning once control has been replaced by trust. This position, for educators, is not about withdrawing; it means stepping in and being there, actively providing guidance, taking the risk of doing instead of telling, taking responsibility together. For students, it means designing their learning pathway and their own future in art.
Allowing diversity always includes letting go, of hierarchy, of status, of secured positions and visions. This is scary. But how else can our artform develop and play a role in contemporary societies? We cannot just teach history. We can teach quality while relating to what young professionals, children of their time, are creating. Classical music touches on everything which is human, and it is the most sacred place I know. Being a musician is the best way to spend your life. It is demanding and exciting, but most of all it is a blessing to be able to speak in and for your community with an artistic voice. Diversity is a rule of nature, and inclusion is a mission for artists. If anything, let conservatoires be places of joy and belonging, mini-societies for experimentation, thinking, and playing while being aware of context, place, and time.
CO: I do not feel that I can put forward a general vision for the conservatory system in Europe, but what I will work for and hope to see in the future is a closer connection between the conservatoire and society in general. In my opinion, building this connection requires a change in mindset on all institutional levels, which comes from many of the things that have been brought up throughout this interview and that are also reflected in our manifesto above. Like asking ourselves why we do that we do, encouraging curiosity and breaking down the hierarchical structures that stand in the way of diverse and nuanced learning, as well as putting music in the hands of the people. I believe that such a change will enhance diversity and innovation and create new areas of work for musicians to benefit both the musicians themselves and society in general. Therefore, as a music creator and educator, I dedicate myself and my work to curiosity, to lifelong learning, and to supporting others in following their dreams.
Camilla Overgaard is a guitarist and songwriter who specialises in the acoustic guitar. She holds a bachelor's degree in music pedagogics, with classical guitar as her main instrument, and a master's degree in pop/jazz guitar and song writing from The Royal Academy of Music in Aarhus. She is highly engaged in representational work both as former chair of the students' council and of The National Council of Music Students and as a board member of the Danish Musicians Union. Camilla is involved in a variety of different projects combining elements from classical and folk music and has collaborated with both actors and architects. In March 2019, she released her debut EP "Det er ganske vist!" with her interpretations of fairy tales by the famous Danish author Hans Christian Andersen. Since 2018, Camilla has been part of the AEC SMS-project as a member of the Student Working Group and as co-chair of the Entrepreneurship Working Group. She works to combine social entrepreneurship and music with the aim of empowering vulnerable groups in society. In relation to her master's thesis "Meeting in Music - Facilitating empowerment and sense of ownership through musical activities with vulnerable groups," Camilla initiated two projects, one in a refugee centre and the other in a community centre, exploring how meeting in music can contribute to strengthening the personal resources of people who are considered very vulnerable, help foster intercultural understanding and build social relationships.
Susanne van Els (1963) is one of the leading musicians of her generation. She performed as a soloist and a chamber musician, and she ran a most entrepreneurial life in music, combining her own ensembles and projects, like a series of artistically fresh solo CDs, with travelling the world with the Schönberg Ensemble, doing advisory and policy development work whilst undertaking adventurous collaborations with the other arts. Significant composers like Louis Andriessen wrote new viola works for Susanne. Her recording of Ligeti's viola sonata for harmonia mundi won both the Diapason d'Or de l'Année and the Deutsche Schallplattenpreis in 2009. After this truly satisfying international career, she started to work in higher education. She was the head of the classical music department of the Royal Conservatoire The Hague. She was responsible for the interdisciplinary projects and joint curriculum at ZUYD Faculty of the Arts. For these institutions, she developed relations with international higher education partners, a.o. in China. She led the European Opera Academy and is currently working on an Erasmus+ Strategic Partnership project for new opera-making and training. She is involved in new initiatives in the arts, and she does policy advice, coaching, and accreditation work. Susanne is a member of the Learning & Teaching working group of the Strengthening Music in Society project of the Association Européenne des Conservatoires. She performs forward-thinking work on assessment and curriculum development in higher music education—a recent article in a publication of the Centre of Excellence in Music Performance Education is "How (not) to teach."


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Player: Bobby Wine
Sent: 7/6/19
Return: 8/2/19 (44 days)
Ratio: 2/2
Address Source: Norristown, PA address listed on SCF.
This is the longest I've waited for a return at 111 days. But for an 80 year old, Bobby Wine is still returning autographs for fans and still has a great, fluid, sharp signature.
Wine was a Phillies' amateur signing in 1957 and made his Major League debut in 1960. He bounced back after 154 games and didn't get back to Philly until '62. Despite chronic injury issues, Wine hung on, playing for the 1964 Phils who had a legendary collapse. In '69 Wine was sent to the expansion Expos as compensation for Larry Jackson, who chose retirement over playing in Montreal. Bobby played three season for les Expos de Montreal.
After retiring Wine almost immediately went to work as a coach for the Phillies, helping the team rebuild in a worst-to-first from 1976 to 1978 and was with the squad through their 2 World Series appearances in the 80's.
Bobby's son Robbie had a cup of coffee with the Astros before becoming a coach (currently with San Diego), and his grandson Cory was drafted by the Phillies deep in the 2009 draft.
This is return number 29 and card number 30 for the Phillies' TTM Frankenset we've been building since April. I only sent Bobby one copy of this card (I always print two, and the other one did not cut cleanly). If you want to see the rest of the Frankenset cards, click here.


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Minecraft has been around since 2011, and since then, the landscape of gaming has change drastically. Dozens of developers have taken inspiration from the sandbox game and introduced some of its ideas to other genres. Terraria adapts Minecraft's concepts to a 2-D world while Ace of Spades applies the build-it-yourself gameplay to shooters.
Those are both compelling experiences, but few have tried to go head to head with Mojang's landmark title. No one has tried to build a better Minecraft. But that changes this month as 505 Games has partnered with Keen Games to create Portal Knights.
The sandbox project, which is now in Early Access on Steam for $14.99, looks like an updated version of Minecraft. Lushly textured blocks replaces the 8-bit-looking voxels. Players can still dig through procedurally generated worlds, gather resources and craft objects, but with Portal Knights, there's more of an action role-playing approach to how players adventure through the world.
Players can pick from three classes a ranger, from left, a warrior and a mage.
Players choose from one of three classes: warrior, mage and ranger. Each has its own traits. Warriors have high health and are there to go toe to toe with foes. Rangers attack from afar while mages blast enemies with spells. Although all characters can craft any type of gear, some equipment works better for one class than another. For example, metal armor benefits warriors more than rangers while rangers can efficiently use bows while warriors cannot.
"We wanted people to able to express themselves with the characters," creative manager David Welch said.
In addition to gear, there are also talent trees available to the three classes. Some upgrades are geared toward combat while others focus on resources and camping. The different branches ensures that each hero plays differently when friends team up to venture through the realms. If players feel like them made a wrong decision, there's always the option to respec.
As for the world itself, Portal Knights is divided into 44 smaller islands, and players have to unlock them by fixing portals on each island. That's done by gathering portal shards during their adventures. Players can find them by exploring dungeons and finding treasures chests or by defeating a boss on the island.
Combat is largely inspired by games such as The Legend of Zelda.
Each island has different theme and set of resources, so to obtain better gear, it's important for players to open up as many portals as possible and explore the realms. What's great is that Keen Games sought to make the experience as easy as possible. Players don't have to go through a series of portals to get to their destination. They can go from point A to point B by simply opening up the menu and selecting the unlocked island.
Lastly, Portal Knight's combat is more complex than the one in Minecraft. Players can explore and battle monsters in the first-person mode, but the campaign seems to be bettered played in the third person. That way players can strafe and dodge enemy attacks. In one boss fight against a fire dragon, players have to avoid the eggs it throws. When the beast tires itself out, players have an opportunity to fight back by knocking those eggs into the beast. It's a very Zelda-like mechanic, but then again, much of combat is influenced by the venerable Nintendo game.
At the moment, Portal Knights supports up to four players for online play. But because it's in Early Access on Steam, the game has room to grow. At the moment, there's no controller support. The game has about 200 to 250 items to craft and the level cap is 30. But that can all change based on player's feedback, Welch said.
Images courtesy of 505 Games


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New features further enhance the Sierra Wireless Embedded Application Framework, helping developers reduce cost and time to market.
At the Mobile World Congress in Barcelona, Spain this week, Sierra Wireless is presenting several new features of its platform for embedded machine-to-machine (M2M) application development, including a new third-party library, an integrated debugger, and a new user interface for remote device management.
Unique in the market, Sierra Wireless AirPrime embedded modules natively support a complete embedded application framework for rapid M2M application development. The Sierra Wireless Embedded Application Framework offers a range of readily available building blocks which accelerate the application development process, allowing device and system manufacturers to bring products to market faster and reduce development costs. The Embedded Application Framework consists of an M2M-specific operating system (Open AT), a range of software libraries, and an integrated development environment.
AirPrime wireless modules can also be remotely managed thanks to AirPrime Management Services, a comprehensive set of device management capabilities. In addition, to support creation of and integration to business applications, AirPrime modules can be connected to the AirVantage Services Platform through the AirVantage Ready Agent. These capabilities and the seamless integration of hardware, software and services significantly simplify and accelerate the end-to-end development of M2M applications.
Sierra Wireless is continuously expanding the development platform with new features, through in-house development and now through collaboration with third-party software developers. A recent enhancement is the WirelessIDEA library developed by Aplix Corporation, which enables developers using Sierra Wireless modules to write their M2M applications in the popular Java programming language. Benefits include faster development of high-level tasks, hardware platform portability, and re-use of existing code. The WirelessIDEA library works seamlessly with the Sierra Wireless Embedded Developer Studio, an Eclipse™-based integrated development environment for M2M applications.
Ryu Koriyama, CEO of Aplix Corporation, commented: "The Sierra Wireless Embedded Application Framework is a truly powerful software environment, and a reference in the M2M industry. We are very pleased to be able to provide our WirelessIDEA library to the community of M2M solution developers using Sierra Wireless products, enabling them to work in their programming language of choice and helping them reduce their time to market."
Sierra Wireless is also introducing a new user interface for its AirPrime Management Services. Based on the AirVantage Services Platform, this cloud-based device management solution enables manufacturers (or their service provider customers) to remotely monitor and upgrade AirPrime devices in the field through a web portal, saving considerable operating costs. The new user interface includes the possibility to create dashboards in order to monitor key parameters and communication traffic of a group of devices, to configure them, and to remotely send AT commands. It also performs remote upgrade campaigns through a secure patch mechanism.
Didier Dutronc, Senior Vice President and General Manager, M2M Embedded Solutions for Sierra Wireless, said: "The installed base of wireless-enabled machines powered by the Open AT operating system now counts several million devices. Since the launch of Open AT ten years ago, a great ecosystem of creative embedded software developers has evolved. We are delighted to welcome new members such as Aplix Corporation, in order to continue to facilitate and accelerate M2M application development."
About the Sierra Wireless Embedded Application Framework
The Sierra Wireless Embedded Application Framework is a complete software package for embedded M2M application development. It includes the following elements:
Open AT OS:
Open AT OS is the world's only operating system designed specifically for M2M. It natively provides wireless services (voice call, data call, SMS) and TCP/IP connectivity, and gives access to hardware resources for which the developer would otherwise need an extra processor. Open AT OS makes it possible to use an AirPrime wireless module as a standalone processor for simple applications, or as a co-processor for more complex systems. The operating system enables developers to easily write their applications in standard ANSI C/C++, which is optimized for real-time control and low-level services control.
Developers using the Open AT OS in their M2M solutions can also take advantage of a series of libraries offered by Sierra Wireless and third-party software vendors, in order to easily add extra features and protocols or to use other development languages than C/C++.
Sierra Wireless Libraries:
Sierra Wireless offers a range of off-the-shelf libraries for easy access to some of the most popular add-on technologies.
Available libraries include:
- Lua Interpreter: Lua is a popular scripting language which simplifies application development by dealing with tasks such as memory, data flow, and control flow management.
- Internet: Adds FTP, POP3, SMTP and HTTP protocols
- Location: Facilitates integration of GPS and A-GPS features
- Security: Adds SSL, cryptographic and jamming detection protocols
- Ready Agent: Connects modules to the AirVantage Services Platform
Third-party libraries:
The WirelessIDEA library from Aplix Corporation allows developers using Sierra Wireless modules to write their applications in Java, enabling them to select the programming language that best suits their skill sets and tasks. They can program in C/C++ and Java at the same time, using C/C++ for performance-critical work and Java for higher level programming. The WirelessIDEA library can be deployed on Open AT-enabled devices already in the field.
Several other third-party libraries will be introduced shortly, including industry-specific protocols for Energy, Healthcare and Sales & Payment solutions.
Developer Studio:
The Sierra Wireless Embedded Developer Studio is an integrated development environment for M2M applications, based on Eclipse™. It integrates the entire development process into a single tool, including coding, debugging, target download, and target monitoring. The next version, 2.0, will include a new embedded debugging feature which enables developers to speed up embedded software fine-tuning by managing application execution through suspend/resume, step-by-step, breakpoints and data watch capabilities.
About the AirVantage Services Platform
The Sierra Wireless AirVantage Platform is a secure cloud platform that enables M2M solution providers, system integrators and network operators to rapidly develop, deploy, and operate M2M applications and services. The AirVantage Platform includes comprehensive applications to manage cellular subscriptions, communications devices and their attached assets (such as components in machines, telemetric devices in automobiles, and monitoring devices in a home or office); a powerful set of M2M application development tools; and an open web services application programming interface (API). The AirVantage Platform lets wireless network operators extend operational self-support, application development, and management capabilities to their M2M service providers.


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The Next Frontier of Microbiome Science
Probiotics aren't just for your gut anymore. But what exactly is microbiome science,
and how can gut microbes affect your immune and lung health?
Did you know there could be as many bacterial cells as there are human cells in a healthy human body? From the moment we take our first breath, the world around us is influencing our microbiome. And in turn, our microbiome is influencing our health.
People have been consuming live probiotics for gut health for centuries. In more recent decades, scientists have discovered that gut microbes also play important roles in other bodily systems – from immune response, to mental wellbeing, and even lung health!
The physician scientists behind ResBiotic were among the first to sequence the lung microbiome, and to examine the dynamic connections between gut and lung health. Founder Dr. Vivek Lal and Chief Medical Officer Dr. Amit Gaggar collaborated to better understand the role of the microbiome in regulating inflammatory pathways, and developed a blend that supports lung structure and function through the gut-lung axis.*
A proprietary combination of clinically studied probiotic strains and anti-inflammatory herbs, scientifically engineered to support lung structure and a healthy inflammatory response.*
From strain validation and product formulation to testing, we're collaborating with leading scientists and research partners to develop the first microbiome-based nutritional interventions for lung health.
Our strain bank is maintained with ResBiotic's own proprietary deposits, all backed by clinical (in vivo) and laboratory (in vitro) proof on concept and safety data. Our blend is formulated by optimizing indicative biomarker responses in tissue cells to better optimize support for the lungs. All of our strains have had their full genomes sequenced.
Our strain bank is maintained with ResBiotic's own proprietary deposits, all backed by clinical (in vivo) and laboratory (in vitro) proof on concept and safety data. Our blend is formulated by optimizing indicative biomarker responses in tissue cells to better optimize support for the lungs. All of our strains have had their full genomes sequenced.
Each capsule contains ancient botanical extracts produced in a cGmP (Current Good Manufacturing Processes) environment by FDA-certified suppliers, specifically processed for extended stability and probiotic longevity. The combination of probiotics and botanical extracts combine to create a truly unique formulation, tailored toward lung support.
ResBiotic's strain blend is produced via biofermentation at massive scale through optimizing fermentation temperature, pH, mother culture purity, and other factors. Each strain is enumerated and precision-blended to yield a consistent colony forming unit (CFU) count in each capsule, every time.
Every batch is analyzed for impurities, precision-blended according to current Good Manufacturing Practices (cGMP) from FDA-compliant manufacturing facilities, and sent to you from our FDA-registered fulfillment center. We only release to the public products that have met stringent quality, purity, and analytical testing requirements.
Answered by Dr. Kent Willis
Answered by Dr. Amit Gaggar
Answered by Dr. Amit Gaggar
Founder & CEO
Chief Medical Officer
Director, Lab Operations
Advisor (Pediatric Lung Disease)
Endowed Professor & Virginia Walker Chair in Pediatrics, University of Alabama at Birmingham
Advisor (Microbiome, Adult Lung Disease)
Associate Professor, Pulmonary & Critical Care Medicine & Director Huang Microbiome Lab, University of Michigan
Advisor (Lung Transplant)
Assistant Professor Medical Director Lung Transplantation Program, Brigham & Women's, Harvard University
Advisor (Gut-Lung Axis, Mycobiome)
Assistant Professor & Director, Willis Lung Lab, University of Alabama at Birmingham
Advisor (Clinical Trials, Adult Lung Disease)
Associate Professor, Pulmonary & Critical Care Medicine, University of Alabama at Birmingham
Advisor (Microbiome)
Professor Emeritus, Microbiome Resource Center & Cell Development & Integrative Biology, University of Alabama at Birmingham
Completed and ongoing studies of resB® Lung Support include
This was a randomized, open-label clinical trial in Cork, Ireland with healthy and asthmatic patients who took one resB® capsule twice daily (one in the morning, one at night) for one month.
Primary outcomes include testing safety measures. All participants tolerated the blend without adverse events.
Exploratory outcomes investigated changes in gut microbiota, serum MMP-9 and cytokines, CRP, lung function, oxygen levels, and changes in quality of life.
Completed 2022 – View Results
This is a multi-center randomized control trial in the United States with a dosing period of three months.
Primary outcomes center on change in quality of life.
Exploratory outcomes investigate clinical improvement markers (e.g., FEV1/FVC), gut and
lung microbiota, systemic and pulmonary biomarker changes (e.g., MMP-9, CRP,
cytokines, etc.)
This is a single-center randomized control trial in India with a dosing period of 14 days.
Primary outcomes center around pneumonia incidence and prognosis in elderly population in an acute care setting.
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Nominated: Debut Novel & Last Laugh Awards at CrimeFest 2022
Shaking Hands With The Devil
What happens when a serial killer and a hapless detective start to get on each other's nerves? (ALSO AVAILABLE ON AUDIBLE SEPTEMBER 23)
30 years since the first draft, this hilarious black comedy can at last be read.
Clifton Gentle is an apparently ordinary man without very much to distinguish him. Not much, that is, apart from being a serial killer leaving bits of young men scattered over North London.
Dave Hicks is the flawed detective determined to catch him, but his attempts to capture the man he calls 'the nutter' through a combination of hunches, sheer optimism and personal abuse do not go well. All that turns up are yet more body parts.
In a London dogged by growing sleaze and an IRA bombing campaign, the gruesome murders spur a crazily over-the-top media and merchandising frenzy.
An increasingly personal feud ends up in a race against time as murderer, detective, a would-be victim, and a deranged copycat killer each try to find out what – or who – they blame for their predicament.
But what do readers say?
Reviews for Shaking hands with the devil:
'The author expertly combines comedy with tiptoeing into the sinister underbelly of society…a great read- M Wiltshre, Amazon
'A wonderful romp' – A Ursell, Amazon
'Full of black humour…pacy and well written with marvellous wit' – Deb's Book Reviews
'Ooh, I liked this. Unusual, for all the right reasons…some truly laugh out loud moments' – Bobs and Books
'A satirical tale from a master wit at his quirky, provocative best' – Crime Fiction Critic
'If you love crime with a funny, albeit dark, side, give this book a go' – Beyond the Books
'I read some odd books at times, and this is right up there…a really cracking read' – Donna Morfett
'Had me sniggering a lot and laughing out loud' – Lynda Checkley
'Raskalnikov meets Ignatius J Reilly' – Skybatwig, Amazon
'High drama with great characterization and wonderful language. I couldn't put this book down' – Carolyn, Amazon
'A ton of wit and intriguing writing that really kept me engaged' – Jessica Belmont, Goodreads
'Mason is definitely an author to appreciate…he gives a lot of respect to his craft' – Natalie 'Curling up with a coffee and a Kindle'
'A must for those who like their satire as black as night' – David Prestidge, Goodreads
'I was so taken aback at how this author created something soe immenselyy disturing that was also completely comical' – Nicola Hancock, Amazon
'What a fun read…right up my street' – Deb's reviews.
Once thought ahead of its time, the moment has finally arrived for this outrageous black comedy crime noir novel
bryan j mason
Bryan J Mason has been on a long journey.
He wrote this novel in London in the late 1980s, but reluctantly concluded that he was a failed author after it was rejected by publishers at the time, so thought that he ought to go on and be a failure at something else. Which largely he has. Determined to finally get it read, he redrafted it and…here it is.
In the intervening years he has worked as a brush salesman and rent collector, made sound effects for BBC Radio and been a tax inspector and occasional actor. He writes regular theatre reviews for StageTalk Magazine and Bristol 24/7. Theatre reviews are available here: https://stagetalkmagazine.com/p/author/masonbryan01gmail-com
Shaking Hands with the Devil is Bryan's first novel.
His second black comedy novel awaiting publication, An Old Tin Can, features a Jewish detective in Belfast who discovers that there is a serial killer at large during the turbulence of identity politics present in the Troubles.
He lives in Bristol with his wife and has two children in their twenties.
Launch and Media updates
Thanks to everyone who contributed to my Book Tour in March 2022 hosted by the wonderful Zooloos Book Tours: For wrap up See here
Q&A with Bantam Book Worm
Review and Q&A with Els Ebaert – B for Book Review
Launch events took place in BookHaus, Bristol and the Clifton Village branch of Waterstones in Nov 21
BookHaus launch reading:Book Haus Launch read
Waterstones launch intro
BookHaus Launch reading: Dave Hicks
BookHaus reading number 2
Thanks also to Donna Morfett for a fab chat with Little Miss Morfett available on Audible and BBC Radio Bristol's Steve Yabsley for two great interviews including a catch up on 4 March 2023.
Audible Little Miss Morfett
Staff recommendation in my local Waterstones!


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1. Name of the medicinal product
a) Doxepin Capsules USP 10mg Taj Pharma
b) Doxepin Capsules USP 25mg Taj Pharma
c) Doxepin Capsules USP 50mg Taj Pharma
d) Doxepin Capsules USP 75mg Taj Pharma
e) Doxepin Capsules USP 100mg Taj Pharma
f) Doxepin Capsules USP 150mg Taj Pharma
2. Qualitative and quantitative composition
a) Each capsule contains:
Doxepin Hydrochloride USP
equivalent to 10mg of Doxepin.
Excipients q.s.
b) Each capsule contains:
Doxepin Hydrochloride USP
equivalent to 25mg of Doxepin.
Excipients q.s.
c) Each capsule contains:
Doxepin Hydrochloride USP
equivalent to 50mg of Doxepin.
Excipients q.s.
d) Each capsule contains:
Doxepin Hydrochloride USP
equivalent to 75mg of Doxepin.
Excipients q.s.
e) Each capsule contains:
Doxepin Hydrochloride USP
equivalent to 100mg of Doxepin.
Excipients q.s.
f) Each capsule contains:
Doxepin Hydrochloride USP
equivalent to 150mg of Doxepin.
Excipients q.s.
3. Pharmaceutical form
Capsules for oral administration.
4. Clinical particulars
4.1 Therapeutic indications
Symptoms of depressive illness, especially where sedation is required.
4.2 Posology and method of administration
The optimum oral dose depends on the severity of the condition and the individual patient's response. The dose required may vary from 25-300mg daily. Doses up to 100mg daily may be given on a divided or once daily schedule. Should doses over 100mg daily be required, they should be administered in three divided doses daily. 100mg is the maximum dose recommended at any one time. This dose may be given at bedtime.
For the majority of patients with moderate or severe symptoms, it is recommended that treatment commences with an initial dose of 75mg daily. Many of these patients will respond satisfactorily at this dose level. For patients who do not, the dosage may be adjusted according to individual response. In more severely ill patients, it may be necessary to administer a dose of up to 300mg in divided doses daily, to obtain a clinical response.
In patients where insomnia is a troublesome symptom, it is recommended that the total daily dose be divided so that a higher proportion is given for the evening dose; similarly, if drowsiness is experienced as a side effect of treatment, Doxepin 25mg Capsules may be administered by this regimen or the dosage may be reduced. It is often possible, having once obtained a satisfactory therapeutic response, to reduce the dose for maintenance therapy.
The optimal anti-depressant effect may not be evident for two to three weeks.
Use in children The use of Doxepin 25mg Capsules in children under 12 years is not recommended because safe conditions for its use have not been established.
Use in the elderly In general, dose selection for an elderly patient should be cautious, starting at the low end of the dosing range, reflecting the greater susceptibility of elderly people to typical side effects of the drug.
Use in hepatic impairment Dosage reduction may be required in patients with hepatic impairment (see 'Special warnings and special precautions for use').
Use in renal impairment Dosage reduction may be required in patients with renal impairment (see 'Special warnings and special precautions for use').
4.3 Contraindications
Doxepin is contra-indicated in individuals who have shown hypersensitivity to tricyclic antidepressants (TCAs), doxepin, or any of the inactive ingredients.
Doxepin is also contra-indicated in patients with mania, severe liver disease, lactation, glaucoma, tendency to urinary retention.
4.4 Special warnings and precautions for use
Suicide/suicidal thoughts or clinical worsening
Depression is associated with an increased risk of suicidal thoughts, self harm and suicide (suicide related events). This risk persists until significant remission occurs. As improvement many not occur during the first few weeks or more of treatment, patients should be closely monitored until such improvement occurs. It is general clinical experience that the risk of suicide may increase in the early stages of recovery.
Patients with a history of suicide-related events, or those exhibiting a significant degree of suicidal ideation prior to commencement of treatment are known to be at greater risk of suicidal thoughts or suicide attempts, and should receive careful monitoring during treatment. A meta-analysis of placebo-controlled clinical trials of antidepressant drugs in adult patients with psychiatric disorders showed an increased risk of suicidal behaviour with antidepressants compared with placebo in patients less than 25 years old.
Close supervision of patients and in particular those at high risk should accompany drug therapy especially in early treatment and following dose changes. Patients (and caregivers of patients) should be alerted about the need to monitor for any clinical worsening, suicidal behaviour or thoughts and unusual changes in behaviour and to seek medical advice immediately if these symptoms present.
The once-a-day dosage regimen of Doxepin 25mg Capsules in patients with intercurrent illness or patients taking other medications should be carefully adjusted. This is especially important in patients receiving other medications with anti-cholinergic effects.
The use of Doxepin 25mg Capsules on a once-a-day dosage regimen in geriatric patients should be adjusted carefully on the basis of the patient's condition. The elderly are particularly liable to experience toxic effects, especially agitation, confusion and postural hypotension. The initial dose should be increased with caution under close supervision. Half the normal maintenance dose may be sufficient to produce a satisfactory clinical response.
Patients should be warned that drowsiness may occur with the use of Doxepin 25mg Capsules. Patients should also be cautioned that their response to alcohol may be potentiated.
Although Doxepin 25mg Capsules carry less risk than other tricyclic anti-depressants, caution should be observed in the treatment of patients with severe cardiovascular disease, including patients with heart block, cardiac arrhythmia and those who have experienced a recent myocardial infarction.
Use in hepatic/renal impairment Use with caution in patients with hepatic and/or renal impairment.
Use in patients with epilepsy Use with caution in patients with a history of epilepsy.
Since suicide is an inherent risk in any depressed patient until significant improvement has occurred, patients should be closely supervised during early therapy.
Patients with benign prostatic hyperplasia may experience an increase in associated urinary retention (see 'Undesirable effects').
4.5 Interaction with other medicinal products and other forms of interaction
Doxepin, like other tricyclic antidepressants (TCAs), is metabolised by cytochrome P450 (CYP) 2D6. Inhibitors or substrates of CYP2D6 (e.g. quinidine, selective serotonin reuptake inhibitors [SSRIs]) may increase the plasma concentration of TCAs when administered concomitantly. The extent of interaction depends on the variability of effect on CYP2D6 and the therapeutic index of the TCA. The clinical significance of this interaction with doxepin has not been systematically evaluated.
Combined use with other anti-depressants, alcohol or anti-anxiety agents should be undertaken with due recognition of the possibility of potentiation. It is known, for example, that monoamine oxidase inhibitors may potentiate other drug effects, therefore Doxepin 25mg Capsules should not be given concurrently, or within two weeks of cessation of therapy, with monoamine oxidase inhibitors.
Cimetidine has been reported to produce clinically significant fluctuations in steady-state serum concentrations of doxepin.
Doxepin should not be given with sympathomimetic agents such as ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine.
General anaesthetics and local anaesthetics (containing sympathomimetics) given during tricyclic or tetracyclic anti-depressant therapy may increase the risk of arrhythmias and hypotension, or hypertension. If surgery is necessary, the anaesthetist should be informed that a patient is being so treated.
Doxepin may decrease the anti-hypertensive effect of agents such as debrisoquine, bethanidine, guanethidine and possibly clonidine. It usually requires daily doses of doxepin in excess of 150mg before any effect on the action of guanethidine is seen. It would be advisable to review all anti-hypertensive therapy during treatment with tricyclic anti-depressants.
Barbiturates may increase the rate of metabolism of doxepin.
Doxepin 25mg Capsules may reduce the effect of sublingual nitrates owing to dry mouth.
The dose of thyroid hormone medication may need reducing if Doxepin 25mg Capsules are being given concurrently.
4.6 Fertility, pregnancy and lactation
Doxepin crosses the placenta. Reproduction studies have been performed in rats, rabbits and monkeys and there was no evidence of harm to the animal foetus. The relevance to humans is not known. Since there is insufficient experience in pregnant women who have received this drug, its safety in pregnancy has not been established.
Doxepin and its active metabolite desmethyldoxepin are excreted in breast milk. There has been a report of apnoea and drowsiness occurring in a nursing infant whose mother was taking doxepin. The use of Doxepin 25mg Capsules is contraindicated during lactation.
4.7 Effects on ability to drive and use machines
Since drowsiness may occur with the use of Doxepin 25mg Capsules, patients should be warned of the possibility and cautioned against driving a car or operating machinery while taking this drug.
4.8 Undesirable effects
Doxepin 25mg Capsules are well tolerated. Most side-effects are mild and generally disappear with continued treatment, or if necessary a reduction in dose.
Note Some of the side-effects noted below have not been specifically reported with Doxepin 25mg Capsules. However, due to the close pharmacological similarities amongst the tricyclics, the reactions should be considered when prescribing Doxepin 25mg Capsules.
The most common side-effects to Doxepin 25mg Capsules are drowsiness, dry mouth and constipation. For further details see below under central nervous system and anti-cholinergic effects.
Suicidal Ideation and Behaviours Cases of suicidal ideation and suicidal behaviours have been reported during doxepin therapy or early after treatment discontinuation (see section 4.4).
Bone fractures Epidemiological studies, mainly conducted in patients 50 years of age and older, show an increased risk of bone fractures in patients receiving SSRIs and TCAs. The mechanism leading to this risk is unknown.
Anti-cholinergic effects Anti-cholinergic effects are relatively common and may occur immediately following the first dose of a tricyclic anti-depressant. Dry mouth and constipation are the most common anti-cholinergic effects. Blurred vision and sweating occur occasionally. Urinary retention is rare except in predisposed males who have an enlarged prostate gland. Tolerance is often achieved if treatment is continued. If these undesirable effects do not subside with continued therapy, or if they become severe, it may be necessary to reduce the dosage.
Central nervous system effects Drowsiness is the most commonly noticed side effect. This tends to disappear as therapy is continued. Insomnia and nightmares have also been reported. Other infrequently reported CNS side effects are confusion, disorientation, agitation, numbness or paraesthesiae, tremor (which is usually mild). But at high doses, in susceptible individuals (particularly the elderly) other extrapyramidal symptoms may occur including tardive dyskinesia. Rarely reported are hallucinations, ataxia (generally where mixtures of CNS drugs have been given), and convulsions. Convulsions are unlikely except in people predisposed to seizure activity by brain damage or alcohol and drug abuse.
Psychotic manifestations, including mania and paranoid delusions may be exacerbated during treatment with tricyclic anti-depressants.
Cardiovascular Cardiovascular effects including postural hypotension, and tachycardia have been reported occasionally and changes in ECG parameters (widening of the QRS and PR interval) very rarely (see 'Special warnings and special precautions for use').
Allergic Allergic reactions to tricyclic anti-depressants are uncommon. They include skin rash, facial oedema, photosensitisation, pruritus and urticaria.
Haematological Rare cases of eosinophilia and bone marrow depression manifesting as agranulocytosis, leucopenia, thrombocytopenia and purpura. Haemolytic anaemia.
Gastro-intestinal Nausea, vomiting, indigestion, taste disturbances, diarrhoea, anorexia and aphthous stomatitis have been reported (see 'Anti-cholinergic effects').
Endocrine Occasional reports of raised or lowered libido, testicular swelling, raised or lowered blood sugar levels. Rarely the syndrome of inappropriate anti-diuretic hormone secretion, gynaecomastia, enlargement of breasts and galactorrhoea in the female.
Other Dizziness, weight gain, chills, fatigue, weakness, flushing, alopecia, headache, exacerbation of asthma and hyperpyrexia (in association with chlorpromazine) have been occasionally observed. Rare reports of jaundice and of tinnitus.
Withdrawal Withdrawal symptoms may occur on abrupt cessation of tricyclic anti-depressant therapy and include insomnia, irritability and excessive perspiration. Withdrawal symptoms in neonates whose mothers received tricyclic anti-depressants during the third trimester have also been reported and include respiratory depression, convulsions and "jitteriness" (hyper-reflexia).
4.9 Overdose
Signs and symptoms
Mild: drowsiness, stupor, blurred vision, excessive dryness of mouth.
Severe: respiratory depression, hypotension, coma, convulsions, cardiac arrhythmias and tachycardias.
Also urinary retention (bladder atony), decreased gastrointestinal motility (paralytic ileus), hyperthermia (or hypothermia), hypertension, dilated pupils, hyperactive reflexes.
Deaths have been reported involving overdoses of doxepin. The reported cases involved doxepin alone and in combination with other drugs and/or alcohol.
Management and treatment
Mild: observation and supportive therapy is all that is usually necessary.
Severe: medical management of severe doxepin overdosage consists of aggressive supportive therapy. If the patient is conscious, gastric lavage with appropriate precautions to prevent pulmonary aspiration should be performed even though doxepin is rapidly absorbed. The use of activated charcoal has been recommended, as has been continuous gastric lavage with saline for 24 hours or more. An adequate airway should be established in comatose patients and assisted ventilation used if necessary. ECG monitoring may be required for several days, since relapse after apparent recovery has been reported. Arrhythmias should be treated with the appropriate anti-arrhythmic agent. It has been reported that many of the cardiovascular and CNS symptoms of tricyclic anti-depressant poisoning in adults may be reversed by the slow intravenous administration of 1mg to 3mg of physostigmine salicylate.
Because physostigmine is rapidly metabolised, the dosage should be repeated as required. Convulsions may respond to standard anti-convulsant therapy. However, barbiturates may potentiate any respiratory depression. Dialysis and forced diuresis generally are not of value in the management of overdosage due to high tissue and protein binding of doxepin.
5. Pharmacological properties
5.1 Pharmacodynamic properties
The mechanism of action of doxepin is not definitely known. It is not a central nervous system stimulant nor a monoamine oxidase inhibitor. The current hypothesis is that the clinical effects are due, at least in part, to influences on the adrenergic activity at the synapses so that deactivation of noradrenaline by reuptake into the nerve terminals is prevented. In animal studies anti-cholinergic, anti-serotonergic and anti-histaminergic effects on smooth muscle have been demonstrated. At higher than usual clinical doses, adrenaline response was potentiated in animals. This effect was not demonstrated in humans.
5.2 Pharmacokinetic properties
Doxepin is well absorbed from the gastro-intestinal tract. Approximately 55%-87% of orally administered doxepin undergoes first pass metabolism in the liver, forming the primary active metabolite desmethyldoxepin.
In healthy volunteers, a single oral dose of 75mg resulted in peak plasma concentrations for doxepin ranging from 8.8-45.8 ng/ml (mean 26.1 ng/ml). Peak levels were reached between 2 and 4 hours (mean 2.9 hours) after administration. Peak levels for the primary metabolite desmethyldoxepin ranged from 4.8-14.5 ng/ml (mean 9.7 ng/ml) and were achieved between 2 and 10 hours after administration. The mean apparent volume of distribution for doxepin is approximately 20 l/kg. The protein binding for doxepin is approximately 76%. In healthy volunteers the plasma elimination half-life of doxepin ranged from 8 to 24 hours (mean 17 hours). The half-life of desmethyldoxepin ranged from 33-80 hours (mean 51 hours). Mean plasma clearance for doxepin is approximately 0.84 1/kg/hr. Paths of metabolism of doxepin include demethylation, N-oxidation, hydroxylation and glucuronide formation. Doxepin is excreted primarily in the urine, mainly as its metabolites, either free or in conjugate form.
5.3 Preclinical safety data
Not applicable.
6. Pharmaceutical particulars
6.1 List of excipients
Doxepin 25mg Capsule: lactose, magnesium stearate, maize starch dried, sodium lauryl sulphate; capsule shell constituents: amaranth (E123), erythrosine (E127), gelatin, patent blue V (E131), sunset yellow (E110) and titanium dioxide (E171).
Doxepin 25mg Capsules are free of gluten and sucrose.
6.2 Incompatibilities
None known.
6.3 Shelf life
3 years.
6.4 Special precautions for storage
Store below 25°C.
6.5 Nature and contents of container
Doxepin 25mg Capsules are available as:
Packs of 28 capsules. Aluminium/PVC blister strips; 2 rows of 7 capsules per strip, 2 strips in a carton box.
6.6 Special precautions for disposal and other handling
No special requirements.
7. Manufactured In India By:
Mumbai, India
Unit No. 214.Old Bake House,
Maharashtra chambers of Commerce Lane,
Fort, Mumbai – 400001
at:Gujarat, INDIA.
Customer Service and Product Inquiries:
Monday through Saturday 9:00 a.m. to 7:00 p.m. EST
E-mail: email@example.com
Doxepin Capsules USP 25mg Taj Pharma
Package leaflet: Information for the patient
a) Doxepin Capsules USP 10mg Taj Pharma
b) Doxepin Capsules USP 25mg Taj Pharma
c) Doxepin Capsules USP 50mg Taj Pharma
d) Doxepin Capsules USP 75mg Taj Pharma
e) Doxepin Capsules USP 100mg Taj Pharma
f) Doxepin Capsules USP 150mg Taj Pharma
Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
– Keep this leaflet. You may need to read it again.
– If you have any further questions, ask your doctor or pharmacist.
– This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
– If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor.
What is in this leaflet
1. What Doxepin Capsules is and what it is used for
2. Before you are given Doxepin Capsules
3. How you will be given Doxepin Capsules
4. Possible side effects
5. How Doxepin Capsules is stored
6. Further Information
1. What Doxepin Capsules is and what it is used for
The name of this medicine is Doxepin 25mg and 50mg Capsules.The active ingredient is doxepin hydrochloride. Doxepin is an antidepressant.
It is one of a group called tricyclic antidepressants. Your doctor has decided that this medicine is suitable for treating your depression.
Depression is a clinical illness. If you have been feeling sad, tearful or unable to enjoy life as you used to, Doxepin Capsules may help you to feel better. It may also help if you have difficulty sleeping because of your depression. If you are not sure why you are on these capsules, ask your doctor.
2. Before you are given Doxepin Capsules
Do not take Doxepin Capsules if:
• You have ever had an allergic reaction to tricyclic antidepressants, doxepin, or any of the inactive ingredients of Doxepin Capsules (see 'Further information' section)
• You have serious liver problems
• You have glaucoma (increased eye pressure)
• You suffer from difficulty in passing urine
• You are breast-feeding
• You are taking, or have taken in the last two weeks, any medicines called monoamine oxidase inhibitors (MAOIs for short)
• You suffer from a type of mood disorder called mania, where you experience an abnormally elevated mood state.
• The patient is under 12 years of age If you suffer from any of the above, speak to your doctor or pharmacist before taking Doxepin Capsules.
Take special care with Doxepin Capsules if:
• You are pregnant or trying to become pregnant
• You have any heart problems
• You have had a heart attack recently
• You have kidney problems
• You suffer from epilepsy (fits)
• You have suicidal thoughts or have attempted suicide in the past
If you answer YES to any of the above questions talk to your doctor before taking this medicine.
If you are taking other medicines
It is very important that you inform your doctor if you are taking or have taken any other medicines, as some medicines may affect the way Doxepin Capsules works.
If you are going to have a surgical operation or dental surgery tell the doctor or dentist in charge that you are taking this medicine.
Some medicines can interfere with the action of Doxepin Capsules and Doxepin Capsules can sometimes affect the action of other medicines. Check with your doctor if you are taking any of the medicines listed below:
• Monoamine oxidase inhibitors. These must not be used with Doxepin Capsules (see 'Before you take Doxepin Capsules' section above)
• Other antidepressants, barbiturates (used to treat insomnia) or other sleeping medicines or medicines for anxiety. Doxepin Capsules will add to their effects and may cause you to feel sleepy or drowsy.
• Medicines to lower blood pressure.
• Sympathomimetics, such as nasal decongestants (used for colds or hay fever) and bronchodilators (used to treat asthma).
• Cimetidine (used to treat ulcers and other stomach complaints).
• Thyroid hormones (used to treat thyroid disorders).
• Chlorpromazine (used to treat mental illness).
• Sublingual nitrates (used to treat angina and heart failure).
Pregnancy and breast-feeding
Do not take this medicine if you are pregnant or trying to become pregnant without consulting your doctor.
Do not take this medicine if you are breast-feeding without consulting your doctor.
Driving and using machines
You may feel sleepy when you take these capsules, do not drive or work with machinery until this effect has worn off.
Alcohol and Doxepin Capsules
Be careful when drinking alcohol. Alcoholic drinks (wine, beer, spirits) may affect you much more than usual.
3. How you will be given Doxepin Capsules
The label on the pack will tell you what dose YOU should take and how often each day to take it. If you are still not sure, ask your doctor or pharmacist.
- Your medicine should only be taken by mouth.
• Swallow your capsules whole with a drink of water.
• Take the capsules while standing or when sitting upright.
• Do not crush or chew the capsules.
• Keep taking the capsules every day • The usual starting dose is 75mg daily. This dose may be increased if necessary .
• The maximum recommended dose is 100mg three times daily.
• If you are elderly these doses may be reduced.
• If you are elderly and require an increased dose of the medicine your doctor may wish to see you regularly.
• If you suffer from liver problems you may also be started on a low dose.
• The capsules may be prescribed once, twice or three times daily.
• Up to 100mg can be given as a single dose.
If you take more Doxepin Capsules than you should
Too many capsules at once can be dangerous. Signs and symptoms of mild overdosage include drowsiness, stupor, blurred vision and excessive dryness of the mouth. Severe overdosage may cause loss of consciousness, reduced breathing rate, convulsions, low blood pressure, unusually fast heart beat or palpitations. If you take too many capsules immediately contact your doctor or nearest hospital Accident and Emergency Department. Do not attempt to drive or work with machinery.
If you forget to take Doxepin Capsules
Do not worry. Take your usual dose at the next correct time.
Do not take a double dose to make up for a forgotten capsule.
If you stop taking Doxepin Capsules
You should always check with your doctor before you stop treatment. Your doctor may want you to reduce gradually the amount you are taking before stopping the medicine completely. This may help to prevent a recurrence of the original trouble and reduce the chance of withdrawal effects such as insomnia, irritability and excessive sweating.
How quickly will the treatment start to work?
• You may take Doxepin Capsules for 2-3 weeks before you start to feel better.
• You must keep taking Doxepin Capsules to help you get better.
• See your doctor before your capsules run out.
• Even if you begin to feel better, keep taking your capsules. You may need to keep taking them to stay well.
What if you do not feel better?
Tell your doctor if:
• You have taken all your medicine and you still feel unwell: or
• You feel worse.
4. Possible Side Effects
Thoughts of suicide and worsening of your depression or anxiety disorder.
If you are depressed and/or have anxiety disorders you can sometimes have thoughts of harming or killing yourself. These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer. You may be more likely to think like this:
– If you have previously had thoughts about killing or harming yourself.
– If you are a young adult. Information from clinical trials has shown an increased risk of suicidal behaviour in adults aged less than 25 years with psychiatric conditions who were treated with an antidepressant.
If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital straight away.You may find it helpful to tellarelative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet. You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour.
Bone fractures
An increased risk of bone fractures has been observed in patients taking this type of medicine.
Doxepin is well tolerated. Most undesirable effects are usually mild and tend to wear off after continued treatment. However, if the side effects are troublesome, your doctor may decide to reduce your dose.
The most common side effects are:
• Drowsiness
• Dry mouth
• Constipation
These are usually mild. If they last for more than several days, check with your doctor.
Less common or rare side effects listed below. If they don't wear off after a few days or trouble you, check with your doctor.
• Dizziness, (if you experience dizziness you should be particularly careful to
stand up slowly).
• Sweating.
• Blurred vision.
• Headache.
• Insomnia.
• Difficulty in passing urine.
• Tiredness.
• Weakness.
• Weight gain.
• Upset stomach.
• Loss of appetite.
• Vomiting or diarrhoea.
• Mouth ulcers.
• Unpleasant taste.
• Fast heart beat (palpitations).
• Changes in sex drive.
• Swelling of testicles
• Chills.
• Flushing.
• Hair loss from the scalp.
• Shakiness or trembling.
• Numbness in the hands or feet.
• Feeling of pins and needles.
• Agitation or confusion.
• Ringing or buzzing in the ears.
Rare side effects: The undesirable effects below are rare but they have occurred in patients taking one of the tricyclic antidepressants, however, not all have occurred with Doxepin.You should check with your doctor immediately if any of the following occur:
– Skin rash, itching, face swelling. Your skin may be more sensitive to sunlight than it is normally.
– At high doses particularly in the elderly, unwanted effects on muscles which may cause slowed movements or stiffness of arms and legs, slurred speech or odd tongue or eye movements.
– Staggering walk which may occur on a mixture of centrally acting drugs.
– Worsening of an existing mental disorder;
– Breast enlargement in both men and women, breast milk production when not pregnant or breast feeding;
– Worsening of asthma.
– Convulsions (fits) are unlikely unless you already suffer from these.
– Nightmares, hallucinations (seeing or hearing things that are not there), jaundice (yellow eyes or skin).
– Changes to the heart rhythm may occur very rarely. Blood disorders; these may cause fever or chills and painful ulceration in the mouth or rectum; unusual bruising or bleeding.
– Abnormal blood tests results i.e.- change in blood sugar levels, lower sodium content of blood and low blood cell count.
Elderly patients: If you are elderly, you may be more likely to be troubled by agitation or confusion
It is important to tell your doctor or pharmacist if you suffer any of these or any other undesirable effects which are not listed above.
5. How Doxepin Capsules is stored
Do not take Doxepin Capsules after the date stamped on the pack.The expiry date refers to the last day of the month.
Doxepin Capsules should be kept in a cool, dry place (below 25ºC).
Keep this medicine out of the sight and reach of children.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.
6. Further information
What Doxepin Capsules contains
The active ingredient in the capsule is Doxepin Hydrochloride USP. The capsules are free of gluten and sucrose.
a) Each capsule contains:Doxepin Hydrochloride USP equivalent to 10mg of Doxepin.
b) Each capsule contains:Doxepin Hydrochloride USP equivalent to 25mg of Doxepin.
c) Each capsule contains:Doxepin Hydrochloride USP equivalent to 50mg of Doxepin.
d) Each capsule contains:Doxepin Hydrochloride USP equivalent to 75mg of Doxepin.
e) Each capsule contains:Doxepin Hydrochloride USP equivalent to 100mg of Doxepin.
f) Each capsule contains: Doxepin Hydrochloride USP equivalent to 150mg of Doxepin.
Other ingredients: lactose, maize starch, magnesium stearate and sodium lauryl sulphate. The gelatin capsules are coloured with erythrosine, (E127), patent blue V (E131) and titanium dioxide (E171).
What Doxepin Capsules looks like and contents of the pack
Doxepin 25mg Capsules (blue and red) come in packs of 28.
Doxepin 50mg Capsules (blue) come in packs of 28.
7. Manufactured In India By:
Mumbai, India
Unit No. 214.Old Bake House,
Maharashtra chambers of Commerce Lane,
Fort, Mumbai – 400001
at:Gujarat, INDIA.
Customer Service and Product Inquiries:
Monday through Saturday 9:00 a.m. to 7:00 p.m. EST
E-mail: firstname.lastname@example.com


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Home About Parking Sponsorship Volunteer Contact Us Login
Breast cancer touches all our lives; although it overwhelmingly affects women, men can be diagnosed too. One in eight women (around 12 percent) developing invasive breast cancer in her lifetime, and there are over 3 million breast cancer survivors in the US alone.
Our goal is simple--to raise funds for the Wilmot Cancer Institute's Breast Cancer Center. Join us this October in our quest to end breast cancer!


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Ethan Allen of Portsmouth is hosting their 2nd Annual Festival of Wreaths to benefit Veterans Count. They have 22 beautiful wreaths that have been designed and donated to be raffled off on 11/25, just in time for the holidays! Raffle tickets can be purchased in-store or online, and the raffle benefits Veterans Count.
We highly recommend seeing these beauties in person. Each in-store raffle purchaser will receive a free Ethan Allen gift. To purchase tickets online visit, https://vetscount.org/nh/events/ethan-allen-festival-wreaths/. Photos of the wreaths can be found on the website as well.


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Sequence Learning with Passive RFID Sensors for Real-Time Bed-Egress Recognition in Older People
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© 2016 IEEE. Getting out of bed and ambulating without supervision is identified as one of the major causes of patient falls in hospitals and nursing homes. Therefore, increased supervision is proposed as a key strategy toward falls prevention. An emerging generation of batteryless, lightweight, and wearable sensors are creating new possibilities for ambulatory monitoring, where the unobtrusive nature of such sensors makes them particularly adapted for monitoring older people. In this study, we investigate the use of a batteryless radio-frequency identification (RFID) tag response to analyze bed-egress movements. We propose a bed-egress movement detection framework that includes a novel sequence learning classifier with a set of features derived from bed-egress motion analysis. We analyzed data from 14 healthy older people (66-86 years old) who wore a wearable embodiment of a batteryless accelerometer integrated RFID sensor platform loosely attached over their clothes at sternum level, and undertook a series of activities including bed-egress in two clinical room settings. The promising results indicate the efficacy of our batteryless bed-egress monitoring framework.
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Low cost and batteryless sensor-enabled radio frequency identification tag based approaches to identify patient bed entry and exit posture transitionsRanasinghe, D.; Shinmoto Torres, R.; Hill, Keith; Visvanathan, R. (2014)Introduction: Falls in hospitals and residential care facilities commonly occur near the bed. The aim of this study was to investigate the accuracy of a continuously wearable, batteryless, low power and low cost monitoring ...
Towards falls prevention: A wearable wireless and battery-less sensing and automatic identification tag for real time monitoring of human movements.Ranasinghe, Damith; Shinmoto Torres, Roberto; Sample, Alanson; Smith, Joshua; Hill, Keith; Visvanathan, Renuka (2012)Falls related injuries among elderly patients in hospitals or residents in residential care facilities is a significant problem that causes emotional and physical trauma to those involved while presenting a rising healthcare ...


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This Super Hard On Booster is an exceptional transparent booster. It gives your guitar and amplifier a lot more 'presence', especially when it is a vintage guitar with weakening elements. Due to the high input impedance sound your old pickups as if on the day of their birth.
And yes …. it has the "Crackle Okay" volume knob. Don't ask me exactly me why that is but if you turn the volume knob you can hear a slight crackling background noise. From the Internet …… The "Crackle Okay" volume knob is a negative-feedback control styled after classic 60's recording console inputs. (They crackled When adjusted too.)
100% Analog Circuitry
True Bypass Switching
Dimensions: 94mm long x 39mm wide x 32mm high
Power: 9VDC, centre negative