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I don't know if you've noticed, but Revolutionary-era historical drama is having a moment (if not a movement) right now. However, not all of it is happening in a room packed with celebrities and people willing to drop way too much money on a night of live theatre. There's an AMC drama that brings all of the 18th century intrigue into your living room. Will Turn: Washington's Spies return for Season 4? AMC has not yet renewed the series, but IMO it would be silly if they didn't — not this year, anyway. Update: On July 26, AMC announced that Turn has been renewed for a fourth and final season, as reported by Deadline.
Earlier: While I'm sure that the AMC series does not want the pressure of being compared to the Tony Award and Pulitzer Prize-winning musical Hamilton, they have to admit that their subject matter is hot right now. If AMC doesn't ride enthusiasm for Hamilton into the sunset by renewing Turn for Season 4, I would be very surprised.
They've already started to borrow from the specifics of the show — which, I realize, is basically unavoidable in historical fiction. Still, Season 3 finally introduced Alexander Hamilton as a character, to the hopeful delight of all crossover Turn and Hamilton fans. What comes next? The show is subtitled Washington's Spies, so what about everyone's favorite spy on the inside, Hercules Mulligan?! I could understand why John Laurens, Hamilton's friend and anti-slavery crusader, might not fit into the AMC series. Washington is clearly a major player, and the Marquis de Lafayette has shown up twice.
I'm not saying that the entire Schuyler family should get involved or anything. This doesn't need to be a Hamilton takeover/adaptation sans music. Who would want that? However, since another less-known historical figure who appears in the musical, the infamously incompetent General Charles "Whee!" Lee, has appeared on the show, it would be cool to at least see their interpretation of Mulligan.
For most of us, seeing Hamilton at least right now is somewhat of a fever dream due to ticket resale prices, availability, and lottery odds. So besides stalking the cast on social media and furiously listening to the cast recording at home, revolutionary-era books and shows like Turn (which is on Netflix right now if you need to catch up) can give fans somewhat of a fix. If I were AMC, I would capitalize on that and keep the show going as long as possible. To the Revolution!
Images: Antony Platt/AMC; Giphy


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He didn't compete in any of the features on Fair Grounds' Santa Super Saturday program, but Three Chimneys Farm's homebred juvenile Principe Guilherme was arguably the most promising participant on the card and the most reliable on a day where favorites took it on the chin in all six stakes races.
The 2-5 favorite against six rivals in a $43,000 first-level allowance, Principe Guilherme seized the early lead, set comfortable fractions, and walloped his competition through the stretch to win by 11 3/4 lengths under Florent Geroux. The final time was 1:42.94 for one mile and 70 yards on a fast track.
Trained by Steve Asmussen, the son of Tapit had won on debut at Churchill Downs November 10, scoring by more than six lengths in a seven-furlong maiden. With two open-lengths scores, Principe Guilherme is likely to aim for Fair Grounds' Kentucky Derby preps: the Lecomte (G3), Risen Star (G2), and TwinSpires.com Louisiana Derby (G2).
The biggest upset of the day occurred in the $75,000 Buddy Diliberto Memorial when the nine-year-old Dimension returned $81.80 after capturing the about 1 1/16-mile turf race by 1 1/4 lengths from Sir Dudley Digges. Up With the Birds was a neck farther back in third, while the runner-up's entrymate, 3-1 favorite Tizzarunner, trailed the field of nine.
Owned by Riverside Bloodstock, trained by Conor Murphy, and ridden by James Graham, Dimension had not placed in seven starts since capturing the King Edward (G2) and Connaught Cup (G2) in back-to-back starts at Woodbine in the summer of 2016.
Cooptado, a champion in Argentina and a former mainstay in Singapore and Dubai, captured the $75,000 Tenacious in a photo over Shut the Box, with Leofric third and 7-5 favorite Money Flows unplaced. Ridden by Declan Cannon for trainer Tom Morley, Cooptado covered one mile and 70 yards on main track in 1:42.78 and paid $36.40.
Owned by Valentin Bukhtoyarov and Evgeny Kappushev, Cooptado had finished third in turf allowances at Keeneland and Fair Grounds in his first two tries stateside.
Earlier, Giada Vegas rallied from last under Corey Lanerie to win the $74,250 Blushing K. D. for fillies and mres by a length from Joyous Thunder, with 6-5 favorite Prado's Sweet Ride a neck behind in third. Time for about 1 1/16 miles on the turf was 1:46.62.
Making her stakes debut following three straight allowance wins on Woodbine's Tapeta surface, Giada Vegas paid $12.80. She's owned by Dixiana Farms and is trained by Mark Casse.
Fresh off the claim for $25,000 by trainer Karl Broberg, Imma Bling pulled the upset in the $74,250 Bonapaw at about 5 1/2 furlongs on the turf. Ridden by Joe Bravo, Imma Bling won by a length from 23-1 chance Balandeen, with 37-1 chance Show Bound third.
Owned by Flurry Racing Stables, Imma Bling returned $24.60 after completing the course in 1:04.67.
The field for the $50,000 Sugar Bowl for two-year-olds was reduced to three following scratches, and it was second choice Land Battle who led wire-to-wire over 1-5 favorite Steel Shot to take the six-furlong dash by 1 1/4 lengths under Jose Valdivia Jr. The winner paid $7.20.
A veteran of six starts going in, including stakes placings at Prairie Meadows, Evangeline Downs, and Remington Park, Land Battle is owned by Norman Stables and trained by Scott Gelner.
In the $50,000 Letellier Memorial for two-year-old fillies, She's Pretty Lucky rebounded from a fourth-place effort in the $82,000 Rags to Riches at Churchill on October 29 to score by a nose over Upset Brewing, with narrow favorite Vision of Justice third.
A homebred racing for Kari Will and trained by Eddie Kenneally, She's Pretty Lucky returned $8 after completing six furlongs in 1:11.06, slightly quicker than the Sugar Bowl time of 1:11.61.

subset: commoncrawl


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Mens 6 mm Black Rhodium over 18k Gold Genuine Diamond Wedding Band Ring 1/2 Ct
Jewelry Unlimited Custome Template 1. Ladies Diamond Bracelets and Bangles. Aleena & Solitaire Rings. Techno Com by KC. View By Ending Time. Sign up for our newsletter to receive great offers on all our jewelry Sign-up. Mens 6 mm Black Rhodium over 18k Gold Genuine Diamond Wedding Band Ring 1/2 Ct. 18 K white gold with Black Rhodium. 100 % Genuine Diamonds. 50 CT Diamond weight. VS2-SI1 Clarity, F-G Color. Size 7 another size available. Only by special order. These are all genuine Clear diamonds set in a Channel setting. The actual diamond weight of the stones is. Great as a Wedding/Fashion band. The ring is a size 7 right now, another size only by special order. The item comes in a Beautiful Presentation Box and appraisal. Jewelry Unlimited is an established Diamond. Gold & Diamond Chains. Men's Diamond Rings. Women's Diamond Rings. Hip Hop Fashion Jewelry. 100% genuine Diamond jewelry. Track Page Views With. Auctiva's FREE Counter. The item "Mens 6 mm Black Rhodium over 18k Gold Genuine Diamond Wedding Band Ring 1/2 Ct" is in sale since Tuesday, March 19, 2013. This item is in the category "Jewelry & Watches\Fine Jewelry\Fine Rings\Diamond". The seller is "jewelryunlimited786″ and is located in Lilburn, Georgia. This item can be shipped worldwide.
- Brand: Jewelry Unlimited
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- Clarity: VS2-Si1
- Cut: Excellent
- Main Stone Treatment: Not Enhanced


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A military academy set up here by a former commando trainer, who left his plum posting after being inspired by actor Nana Patekar's 1991 film 'Prahar', has been working towards not only making soldiers out of children but also bringing them up as sensitive citizens.
Colonel Sunil Deshpande had served as a Commanding Officer of 2 Maratha Light Infantry Battalion and his last posting was at Commando Training Centre in Belgaum where Patekar underwent full-fledged training before actually performing on screen.
Drawing inspiration from the message in 'Prahar' that "the society must have a soldier's mindset with a philanthropic attitude which will automatically make a nation strong," Deshpande left his job and and set up the military training school for children in 2002.
The academy was founded with the motto of "Spreading soldierly conduct and heroic qualities like discipline, courage, patriotism, vigilance and service to mankind".
Col Deshpande was awarded the Vishisht Seva Medal (VSM) for 1965 and 1971 wars. He sought pre-mature retirement in 1993 and established the 'Prahar Jagriti Sanstha' a year later before formally launching the school in 2002.
"The same year Prahar was taken over by CP and Berar Education Society. It has a residential school, jungle training and guidance camp for students interested in joining armed forces, besides outbound training workshops, firing range, regular horse riding facility and a 12-hour non-residential school from fifth standard onwards," Deshpande told PTI.
It has also established an outdoor training facility on an area of 2.66 acres at Umrer near here where obstacle crossing and confidence building camps are carried out. Also, regular camps are organised here for about 150 children, he said.
"Every year, the academy sends children to various military establishments to gain first-hand experience of a disciplined life. It has so far visited various military establishments like the NDA, Army Sports Institute (Pune), CME Infantry School (Mhow) among others," Deshpande added.
Early this month, a group of 30 students visited Army units in Jammu and Kashmir on 'Sadbhawana' Mission.
Source: PTI


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5 Steps to Conquering your 2020 Goals
PART 2 of the "Sexy" goal-setting techniques for the new decade and today I am breaking down the amazing advice of Brendon Burchard and his take on Winning 2020.
Even though it's January 45th -- (why does this month seem so long?) it's never too late to attempt something new. Before setting a goal the same, boring way that we always do, I am taking a look at how 3 top performers plan (and achieve) their goals for the year. Take a peek at last week's Jay Shetty recap here.
This next review is from the energetic Brendon Burchard. His youtube video focuses on kicking your goals and life into high gear. Sidenote: I did need to listen to this video several times for effective and accurate note-taking. This dude talks fast with a TON of information. He has some fantastic one-liners and takeaways that definitely required hitting the rewind button.
1) Establish quarterly, weekly, daily goals. Not sure where I've been for the last 49 years, but attaching a quarterly calendar to personal goals is new to me. I first utilized the quarterly method when following the HB90 Bootcamp for writers as outlined here. Burchard asks the audience - are your goals clear, concise, and intentional?
He suggests that you work backward and create a blueprint of the year, break that down into quarters then into a weekly plan. Burchard questions - are you living in a goal-based plan?
Are you starting Monday with clarity about Friday? This is a unique vision for looking at the week. Burchard uses words like block(time), blueprint, and architect, which offers the audience a sense of creativity. We are the engineers of our time; we are the architects of our goals.
2) Morning work prep. Slightly different than a morning routine (you can see mine here), Burchard's am prep begs the question,"how could I fulfill this day with excellence?" Burchard recommends visualizing the day as complete, all items checked off, all daily goals met. This technique solidifies the success of daily planning. As you can tell from all the questions Burchard poses to the listener - this video is not a nonchalant listen. This is a grab-your-notebook and get busy video.
3) Block time for socials. Mindblowing information coming at you.
Studies prove, the phone (although it has useful properties) not only creates a "weapon of major distraction," it is also a mind-numbing, black hole for time. Burchard dives deep into the math of using our phones without thought or purpose.
30 minutes/day on social media = 3.5 hours /week = 22 workdays
60 minutes/day on social media = 7 hours/ week = 44 workdays = almost 2 months! And so on.
Take a minute. Really, take a minute.
We all know what happens.
Instagram leads to an ad, which leads to searching for those stacked boots with leopard fur, which leads to Pinterest to see how it's styled. Only to find that the boots don't come in your size. So, you head to Facebook, where, (amazingly enough) similar items pop-up in your feed, so you click on that. An hour goes by, you haven't posted your scheduled blog. You haven't liked any of the pics your friends posted and, you still have to check your emails.
Strategic planning and productivity goals squash the cycle of social media IF you are disciplined enough to leave the phone alone.
4) If I had to double the thing that I'm doing, what would I do? Wise words from Burchard lead off his 4th point in this video. If you had to double your income for one week, double your productivity, what would you do and how would it get done? Here, Burchard takes that productivity and daily planning one step further and asks the audience to delegate and eliminate where necessary. What is essential vs. nonessential?
5) Talk with leaders weekly about performance. Similar to Shetty, Burchard suggests the importance of learning and growing. If we are unaware of our progress, our shortcomings, or our successes, how can we achieve our goals?
Burchard amps up the goal-setting technique by looking at the year as a whole, denying the possibility of stagnation and encouraging an entrepreneurial spirit. His method definitely has the heart of a business-based model. Concrete and streamlined, Burchard's video speaks to the realist, the list-maker, the planner.
This video is worth a listen, maybe more than once, to really grasp his model.
Next week, I will be breaking down one of my all time favorite, go-to, media sensation/motivational speaker's goal-setting methods -- Marie Forleo.
Thank you for reading and shoot me a comment on my Facebook, Instagram or on the blog.
Love and Luck,


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Do you find that chocolate chip cookies are so hard to make PERFECT? On the hunt for the perfect Chewy Chocolate Chip cookie, I realized one thing, all the recipes were using Brown Sugar instead of white sugar for "chewy" cookies. I will never make chocolate chip cookies with any white sugar in them again. This recipe produces a chewy cookie that remains soft for over a week!
Chewy Chocolate Chip Cookies
Makes about 26-30 large cookies
- 3 cups all-purpose flour
- 1 1/2 teaspoons baking soda
- 1 1/2 teaspoons salt
- 1 cup unsalted butter, melted and cooled slightly
- 2 1/2 cups packed light brown sugar
- 3 large eggs
- 1 1/2 teaspoons vanilla
- 2 1/2 cups semisweet chocolate chips (16 ounces)
Put oven rack in middle position and preheat oven to 375°F. Line 2 large baking sheets with parchment paper.
Combine flour, baking soda, and salt in a small bowl.
Cream together butter and sugars in a large bowl with an electric mixer at high speed until combined and fluffy. Lightly beat 3 eggs and add to butter mixture, beating with mixer until creamy, about 1 minute. Add in vanilla. Reduce speed to low and mix in flour mixture until just blended (1 cup at a time). Once the batter is mixed, fold in chips.
Scoop around 1/4 cup batter for each large cookie, arranging a few inches apart, on 2 baking sheets. Flatten mounds into 3-inch rounds using the moistened palm of your hand. Form remaining cookies on additional sheets of parchment.
Bake, 1 sheet at a time, until golden, 13 to 15 minutes. Transfer cookies to a rack to cool.


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What had started as an operation with a naked desk in the offices of Pueblo de Oro Development Corporation in Uptown Cagayan de Oro has now finally reached its milestone of inaugurating its own offices in the newly built Primavera City tower in Phase 1, just beside SM City in Pueblo de Oro Business Park, Uptown CDO.
When I was first invited to visit Cagayan de Oro in 2011 I was welcomed in a small container office just next to the long completed Primavera Residences. There was just a desk, a cabinet, and a decorative plant next to a model unit manned by Ms. Gladys Echano, the most loyal and long-lasting of all employees and currently the Sales and Marketing Director of the company. Nobody would have imagined Italpinas to grow so fast and list at the PSE after only 6 years into their existence.
Architect Romolo Nati was convinced about Uptown CdO from the very beginning and had a vision that has been materializing step by step, project after project. The new offices feature a modern and spacious design. The most successful and regarded developer of Cagayan de Oro, many would say, because when there was still no condominium building in town, IDC launched their first project, amidst a mixture of enthusiasm and unmissable critics. As a fierce sustainability and green building advocate, Architect Nati brought his experience of Italian green architecture and design and applied it here in the Philippines. The office blessing was somehow adapted to the current circumstances where larger gatherings are still not allowed but it was nevertheless a festive occasion with an enthusiastic atmosphere.
Employees, key stakeholders, and some loyal investors gathered accompanied by the priest, who conveniently spoke Italian due to the 3 years he spent in Italy. The majestic building, which is apparently soon for turnover to the many buyers, had a greatly decorated and elegant lobby, including the unmissable Christmas tree, a Filipino classic for September. Compared to Primavera Residences, the developer's a finished project that lays just around the corner, this structure and its interior details seem a level above, lush and luxurious. Now I understand what Architect Nati means when he asserts at times that "we learned from the experience of our first project and always try to do better".
So, talking about the offices on the second floor, they seem to be a sort of call center with its many decks and large spaces. It reveals maybe the developer's plan and intention to expand their operations and probably add more projects. Just a guess, but probably not too far-fetched. Aside from the large space for the regular employees, I could see also various enclosed office spaces, most likely for the management. Maybe 6 or 7 with furnished office interiors, a pantry, a conference or board room, and 2 smaller meeting rooms.
All in all a top-of-the-notch office that could impress many in Northern Mindanao as well as in Makati. This is also evidence that the provinces are growing and more companies are settling out of Metro Manila and Metro Cebu. Now it's time for Metro Cagayan de Oro to thrive and conquer the headlines. Italpinas has certainly chosen their location very well as Uptown Cdo is widely considered the BGC of Cagayan de Oro where in fact the price of the land has more than quintupled over the past 10 years. The sales office for Primavera City Phase 2 is located on the ground floor of the building, clearly visible from P. N. Roa Boulevard, amidst other retail spaces that will soon be populated by shops and restaurants.
A great location to attract more curious buyers to avail of the opportunity to enjoy the true condo lifestyle in this green, Edge certified building with an incredible infinity pool and a view from the top.


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Women's Bean Project
eCommerce Retail and Wholesaler Site Build
Specialization in
It includes the behind-the-scenes coding and software applications that allow your website or app to be customized and interactive. Good website development is also key in making sure your website loads fast, loads correctly on different devices, and is easily searchable by website indexers like Google, which all create a user experience that keeps customers and supporters coming back.
What can we do for you
What we have done for others


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In an IT department not so long ago, the main concern of an IT manager was the rate of resolution for helpdesk tickets. However, today's IT department faces a variety of new challenges. As well as being able to efficiently meet the needs of users in a cost-effective way and conducting major technology roll-outs across the company, IT managers are expected to improve the business and make it safer and more profitable.
IT managers are being called on to enhance operations, improve security and beyond most – to provide a competitive advantage through new functionality. A whole new range of tasks is being put onto the CIO's shoulders, requiring additional capabilities and demanding much greater emphasis on areas such as innovation or crafting and orchestrating digital ecosystems.
So how do you do it?
Build a better IT strategy
IT leaders are relied upon to lead their companies' digital advancements by creating an IT strategy that sets the course of innovation while accommodating digital initiatives. But most companies simply don't take the time to plan out an IT strategy. More than they care to admit, people will spend more time researching a new car more than truly understanding the software required to run critical parts of their business. With an explosion of applications, software, and vendors likely to be tenfold of what it was five years ago, who can blame them?
However, businesses – and their owners – still make the mistake of thinking of technology as a "get out of jail free" card. Information technology can be a force multiplier for your business – saving money, making your employees more productive, and allowing you to attract more business but it needs to be delivered on time, on budget and part of a greater business plan. But how can you do this when you're simply trying to keep your head above water?
Add more bodies and build a diverse departmental skillset
New technologies are introduced all the time as is up to the CIO to identify and implement technologies that benefit the company's IT department – and the bottom line. The most obvious solution is to hire more, especially for the infamous "IT department of one" but this doesn't necessarily guarantee success.
Werner Vogul, the Amazon CTO famously once said "There is no compression algorithm for experience", but finding professionals with the right technical knowledge and skills is becoming increasingly more difficult. ISACA estimates that in the IT security sector alone there will be a global shortage of two million professionals in 2020.
IT('s) time for change
Instead of being a support function, IT pro's need to refocus on what will (a) be the backbone for today's digital business and (b) build the processes to succeed in a cloudified world.
The equation couldn't be any simpler: No IT = no digital business. In other words, the success of the CIO on the company's future growth has never been any greater.
Automation: The new outsourcing
Many organizations see automation as the first steps toward satisfying the modernisation of the business at a time when sourcing sufficiently skilled staff remains difficult. The adoption of IT automation promotes a more rapid development and deployment of new applications and can easily be implemented in areas where it's introduction is least painful, and the benefits and the results can be felt right away.
But automation is no magic potion – it won't fix busted processes or eliminate the need for conceptualizing, implementing and managing these processes. What it does do is open greater opportunity. Simply put: anytime a single task – anything from launching a web server, stopping a service, or simply transferring data – is repeatable and its tasks can be automated or built into a series of processes and workflows, which are then orchestrated to run automatically, the traditional benefits of time and cost savings are activated.
Is low code the holy grail?
If automation and orchestration improve tasks efficiency, the question should focus on what is the best tool for the job. Today's digital economy dictates that there's no time to mess around with sloppy code or lengthy development processes that make applications redundant before they're even finished. Instead, we need a "move fast and break things" approach that fosters creativity and innovation.
Finding the holy grail of matching business demands and custom development is a tricky business. Even basic functionalities in standard BPM platforms require you to write a few lines of code to test conditions – whether it's sending and retrieving information from a database using queries, changing task assignment based on a variable value or simply making connections to external applications.
Look Beyond "Same-Same" Application Development
Many of the low-code platforms on the market, in fact, empower users to run applications as well as create them. This distinction is more than superficial, as there are two fundamentally distinct architectural approaches that vendors in this emerging market follow to support apps in a production environment.
First, there are the vendors that take a code generation approach. These tools provide a visual development environment that simplifies the creation of the application – but once it's finished, the platform generates executable code that will run on a Java machine or in a Microsoft runtime environment. These include tools such as Alpha Software, AppGyver, Kony, Lansa, OutSystems, and Progress Kinvey,
Other tools take a model-driven execution approach. In this case, the visual application creation environment generates an intermediate domain-specific representation of the application in question which the platform interprets and executes directly at runtime. This includes tools such as AgilePoint, Appian, Caspio, Linx, Mendix, QuickBase, ServiceNow, and Zudy.
These model-driven execution platforms typically run in a public cloud, although a few vendors offer private cloud and on-premises versions of their platforms, allowing you to run your applications on any choice of environment.
No matter the approach, the goal of low code is to provide you the freedom from routine so you can focus on what matters – running efficient IT systems that contribute to business growth via the ability to collect information, manage it, automate it, and change it, (fast), without writing a single line of code.
Now isn't that something worth (not) writing (code) home about?
The post The economics and benefits of a low code, agile IT department appeared first on the Linx blog.


text: Date: Fri, 16 Apr 93 12:58:46 PDT To: Fun_People Subject: A Replacement fot the Komputerized Kuisinart [As I've mentioned before, we used to refer to a Cuisinart with an embedded microprocessor as the example of extreme high-tech foolishness. Hah! What did we know? This is MUCH better ... --psl] From: <firstname.lastname@example.com> From: Davis Oldham <firstname.lastname@example.com> from the "No Comment" column in this month's Progressive Magazine: New-product listing from Plumbing Heating Piping magazine: "Toilet Seat Video. Video presenting features and benefits of the Washlett SIII micro-computerized wash/dry toilet seat is available in two versions: general audience and medical. General audience demonstrates product and features an endorsement from Dr. Dean Edel, while the medical version also includes testimonials from medical practitioners and end-users." [So not only do we get a new meaning for "end-user, but with a little bit of game software for it, we could probably squeeze some money out of our revolutionary Procto-Switch controller! (Thanks, r.)" --psl]


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It is "extremely likely" that human activities are the "dominant cause" of global warming, according to the the most comprehensive study ever of climate science by U.S. government researchers.
The climate report, obtained by NPR, notes that the past 115 years are "the warmest in the history of modern civilization." The global average temperature has increased by about 1.8 degree Fahrenheit over that period. Greenhouse gases from industry and agriculture are by far the biggest contributor to warming.
The findings contradict statements by President Trump and many of his Cabinet members, who have openly questioned the role humans play in changing the climate.
"I believe that measuring with precision human activity on the climate is something very challenging to do," EPA Administrator Scott Pruitt said in an interview earlier this year. "There's tremendous disagreement about the degree of impact."
That is not consistent with the conclusions of the 600-plus page Climate Science Special Report, which is part of an even larger scientific review known as the fourth National Climate Assessment. The NCA4, as it's known, is the nation's most authoritative assessment of climate science. The report's authors include experts from leading scientific agencies, including the National Oceanic and Atmospheric Administration, NASA and the Department of Energy, as well as academic scientists.


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Chuck Anderson
I've been an avid user and contributor to Fedora and Red Hat Linux before that since about 1997 or so. I've packaged software in the past (Charles R. Anderson's RPM packages for DHCP) and contributed to the Fedora Legacy project during its lifetime. My main interests are QA, testing, bug reporting, and packaging, helping to make Fedora and Linux as a whole the best operating system out there.
For my day job, I am the Network Architect at Northeastern University. Previously, I worked as a Network Engineer and Network Architect at Worcester Polytechnic Institute, where I used Fedora for our internal systems and services provided to the network. I also do a lot of testing of network equipment, with my primary interests being IPv6 deployment and IP multicast, so naturally I'm interested in these topics in Fedora too.
- Email: cra2alum>wpi>edu, cra2fedoraproject>org
- IRC: cra on #fedora, #fedora-devel, #fedora-qa, #networking, #ipv6
- GPG key: Key fingerprint = 652D 750F E0CE 0106 BD6F 03AB B20D 870D C3BD 0068
- Fedora Account: cra
Activities within Fedora
- QA testing.
- Bug reporting, triaging, and occasional fixing.
- Submitted the following packages to Fedora:
- Judy: General purpose dynamic array library
- miredo: Tunneling of IPv6 over UDP through NATs
- msed and sedutil
- ocp: Open Cubic Player for MOD/S3M/XM/IT/SID/MIDI music files
- Currently maintaining/co-maintaining the following packages:
- flac123: Command-line program for playing FLAC audio files
- fping: Scriptable, parallelized ping-like utility
- kpcli: A command line interface to KeePass database files
- lsyncd
- midisport-firmware: Firmware for the M-Audio/Midiman USB MIDI and Audio devices
- ocp: Open Cubic Player for MOD/S3M/XM/IT/SID/MIDI music files
- several perl modules
- rancid
- What I'm currently working on:
- Testing new Fedora releases
- Maintaining packages
- Other packages of interest I may submit soon or be interested in (co-)maintaining:
- eNMS
- Netbox
- ostinato: Packet/Traffic Generator and Analyzer
- nagstamon: Nagios status monitor for the desktop
- sendpage
- LANdb
- xboing
- nosefart
- koules
- bb
- kegs


text:
WASHINGTON, D.C. – Another Congressman from North Carolina has indicated he will object to certifying the electoral college on January 6. Congressman Ted Budd (R-13) says millions of Americans saw what he saw:
Yes, I plan to object on January 6th.
MILLIONS of Americans saw what I saw:
– Voter safeguards removed
– No signature verification
– Outdated voter rolls
– Ballots accepted after Election Day
– Poll watchers denied access
#WeThePeople will keep fighting for @realDonaldTrump.
— Rep. Ted Budd (@RepTedBudd) December 22, 2020
Trending: NOT LADYLIKE: First Lady Kristin Cooper Brags About Flipping Off 'Brainwashed' Child with Trump Sign, Calls Trump Supporters 'A Bunch of Clowns'
Note that Budd doesn't even mention the allegations of outright fraud and/or manipulation. The extralegal rule changes alone, and failures to follow established state laws, constitutes enough uncertainty around the legality of such vote counts that members of congress like Budd see fit to challenge their certification.
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Got a hot news tip for us? Photos or video of a breaking story? Send your tips, photos and videos to email@example.com. All hot tips are immediately forwarded to FIFD Staff.
Have something to say? Send your own guest column or original reporting to email@example.com.


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Sainsbury's has been announced as one of three of the UK's corporate giants to become pioneer organisations for the Living Grid, a new energy ecosystem that aims to create 200MW of flexible power across the UK – enough to power 100,000 kettles – by 2020.
Sainsbury's, United Utilities and Aggregate Industries have been named as the founding partners of Living Grid, and, combined, have the potential to provide up to 39 megawatts of flexible power by the goal date, saving almost 90,000 tonnes of carbon annually in the UK.
It is the first time that a working partnership has been created by leading businesses in the UK to help modernise and relieve pressure on the country's existing static electricity system.
According to Sainsbury's, corporate energy users are uniquely placed to lead the way in influencing the demand side of the electricity grid because their energy needs have a significant impact on peaks and drops in electricity usage.
Brought together by sustainability non-profit organisation Forum for the Future, the Living Grid aims to help create a new energy ecosystem – one that is responsive, intelligent and adapted to make full use of renewable sources of energy.
The initiative works by connecting large corporate energy users' equipment with smart technology powered by founding tech partner Open Energi. Its 'intelligent demand response technology' will allow equipment to continuously adjust electricity usage to adapt to peaks and dips in demand and supply across the grid, without affecting performance.
Paul Crewe, head of sustainability, engineering, energy and environment at Sainsbury's, commented, "Sainsbury's is proud to join our other partners in being a pioneer of the Living Grid and to address one of the UK's most important sustainability issues.
"By joining forces with others to change how we use electricity, we're saving extra carbon emissions for the UK and helping to make our electricity network more efficient, for the benefit of everyone in the UK."
© 2016 European Supermarket Magazine – your source for the latest retail news. Article by Jenny Whelan. To subscribe to ESM: The European Supermarket Magazine, click here.


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Jerash is considered one of the largest and most well-preserved sites of Roman architecture in the world outside Italy. Jerash is now the second-most popular tourist attraction in Jordan, closely ...Read More »
Tag Archives: Jordan
The Six Day War *
The Six Day War involved three distinct battlefronts: Sinai, West Bank and Golan. was the third of the Arab-Israeli wars. As usual David defeated Goliath. Israel and the territories Israel ...Read More »
Jordan Travel Video Guide
Travel video about destination Jordan Many tour organizers will add to their Israeli itinerary a junket to Amman or Petra in Jordan, which is so close but so different from ...Read More »
More than half a million tourists and pilgrims annually come to experience the spirituality and pastoral beauty of the waters of the River Jordan, in which Jesus was baptised by John ...Read More »
Yitzhak Rabin Terminal
The Yitzhak Rabin Terminal, formerly known as the Arava Terminal, serves as a border crossing between Israel and Jordan for Israelis and foreign tourists, with the exception of residents of ...Read More »
Discover Petra, Kingdom of Jordan
Tour to the ancient city of Petra –פטרה (Jordan), the fabled "rose red city,, 1-3 days, departing from Eilat or Tel Aviv . Petra was recognized as a World Heritage Site by UNESCO in 1985. ...Read More »
Petra, Jordan
Petra, Jordan – פטרה Petra is not really in Israel, but since it is included in many tourist packages to Israel'e southern seaport of Eilat in the Israeli Negev, I felt ...Read More »


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She: Cussing weakens your content, but if it works for you…One factor to weave into your enthusiasm for the standards is the readiness of the students to understand and learn the content. As my students were nearly 100% alliterate, pleasure in reading that resulted in sustained silent reading would come before analyzing literature.
Me: The curriculum cannot be designed to first serve the alliterate. Standards must be set for what one should be able to do to succeed in the world. Those with needs such as your students need all the help they can get to be able to read those texts important to understanding well the world and all the thought about the world that thinkers (and the not so thoughtful) produce. To read without being able to analyze, produces what Wayne O'Neil rightfully deemed the "illiterate literate." Stephen Tchudi once said that we need to get rid of those who teach reading and what he meant was that those who teach reading, the reading teachers, are taught to teach the mechanics of reading rather than the purpose or the process by which words are translated into meaning, meaning into significance, and significance into a purpose of some kind, a meaningful response to what is said. He is right in arguing that the reading teachers have had way too much influence in the schools so that all students are looked upon as alliterate unless they can perform as reading teachers specify they should, showing mechanical skill first and then maybe real and deep understanding of what they read and, too, what they see and hear, a real literacy that cannot be taught by teachers versed in the mechanics who are not truly literate in the deep literacy sense, who do not read the difficult texts because, well, they are too hard to read. I have knowing way too many of teachers of this kind, reading teachers who come close to being O'Neil's illiterate literates.


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More details about Tom Coult's chamber opera with playwright Alice Birch have been announced: Violet, a co-production by Music Theatre Wales, Aldeburgh Festival and Theater Magdeburg will be staged across the UK in the summer and autumn of 2020.
A full-length piece of around 80 minutes, for four singers and ensemble of 14 players, the opera has already been shortlisted for the prestigious FEDORA – GENERALI Prize for Opera. Richard Baker will conduct the London Sinfonietta, with the rest of the cast and creative team to be announced shortly.
Loosely inspired by Edgar Allan Poe's The Devil in the Belfry, the opera concerns the inhabitants of a village which begins losing hours from its day – one night, an hour disappears. On day two, two hours are missing, on day three, three are gone. Our story takes place over 24 increasingly short days, as time drains from the world, until the opera snaps shut as the final hour vanishes.


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Int J Biol Sci 2007; 3(7):486-492. doi:10.7150/ijbs.3.486 This issue Cite
Short Research Communication
1. Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
2. Public Health Sciences Administration, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
3. Department of Molecular Medicine/Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
Cofactor of BRCA1 (COBRA1) was first identified as a protein that binds to the breast cancer susceptibility gene product BRCA1. COBRA1 modulates estrogen-dependent and independent transcription and suppresses the growth of breast cancer cells. Its expression is significantly reduced in metastatic and recurrent breast cancer, pointing to a tumor suppressor function in breast cancer development. In light of these initial implications of COBRA1 in human breast cancer, the current investigation sought to obtain more direct functional evidence that links COBRA1 with BRCA1 in transcriptional regulation in breast cancer cells. Small hairpin RNA (shRNA)-mediated gene knockdown and gene expression microarray were used to study the impact of COBRA1 and BRCA1 on global transcription in the same breast cancer cell background. The gene expression profiling study in tissue culture cells uncovers a significant overlap of COBRA1- and BRCA1-regulated genes, many of which have been previously implicated in breast cancer progression. The data shown herein support the notion that COBRA1 and BRCA1 may engage in common gene regulatory pathways to suppress breast cancer progression.
Keywords: COBRA1, BRCA1, transcription regulation, shRNA knockdown, breast cancer.
Cofactor of BRCA1 (COBRA1) was first identified through a yeast two-hybrid screen as a protein that binds to the BRCT domain of the tumor suppressor BRCA1 [1]. In support of its role in transcriptional regulation, COBRA1 is found in the negative elongation factor (NELF) complex, which stalls RNA polymerase II (RNAPII) during transcription elongation in vitro [24]. Furthermore, in vivo studies also demonstrate that COBRA1 and the rest of the NELF complex are recruited to distinct regions of the genome and modulate both estrogen-dependent and -independent expression of cancer-associated genes in breast cancer cell lines [5,6]. Consistent with the in vitro biochemical finding, COBRA1 modulates the movement of the transcription elongation complex at several estrogen-responsive transcription promoters in vivo, thus distinguishing itself from most of the known transcription coregulators that act at the transcription initiation stage [5].
COBRA1 is enriched in the luminal epithelial cells of normal mammary gland [5], and COBRA1 mRNA level has been reported to fluctuate in various breast cancer cell lines [7]. In addition, ectopic expression of COBRA1 in breast cancer cells suppresses tumor cell proliferation, whereas partial depletion of COBRA1 or another NELF subunit (NELF-E) results in accelerated cell colony growth [5]. In addition, COBRA1 expression was inversely correlated with breast cancer progression, with low expression in primary tumors from those patients who had distant metastasis and local recurrence [29]. These observations are consistent with a potential role of COBRA1 in tumor suppression.
Several lines of evidence suggest that COBRA1 and BRCA1 may share a similar functional pathway(s) in transcriptional regulation. First, like COBRA1, BRCA1 modulates ligand-dependent and independent transcription in ERα-positive breast cancer cells [8,9]. Second, both COBRA1 and BRCA1 are physically associated with the promoter region of an estrogen-responsive gene (pS2/TFF1) [5,9]. Third, both proteins interact with the C-terminal domain (CTD) of RNAPII as well as several transcription elongation factors [10, 13]. Lastly, the two proteins also share the property of inducing large-scale chromatin reorganization [1]. Therefore, it is conceivable that the physical interaction between COBRA1 and BRCA1 may facilitate communication between the two proteins and thus mutually coordinate their regulation of common regulatory targets in the genome. In the current study, we took a genome-wide approach to compare the impact of COBRA1 and BRCA1 on global transcription in the same breast cancer cell background. Our work led to the intriguing finding that COBRA1 and BRCA1 knockdown resulted in substantially overlapping gene expression profiles. Furthermore, a number of COBRA1/BRCA1-regulated genes are associated with breast cancer progression.
T47D cells were obtained from the American Type Culture Collection (Manassas, VA, USA) and grown in Dulbecco's Eagle's medium supplemented with 10% fetal bovine serum, penicillin (100 U/ml) and streptomycin (100 μg/ml). Phoenix packaging cells were a generous gift from Dr. David Rekosh at the University of Virginia. The cell lines were tested to be mycoplasma free.
To generate the stable knockdown cell lines, BRCA1 and COBRA1 shRNAs were cloned between the BglII and HindIII sites of the pSUPER.retro/puromycin and pSUPER.retro/neomycin vectors, respectively (Oligoengine). The following sequences directed against BRCA1 and COBRA1 were used: shBRCA1-03: 5'-GAAGCCAGCTCAAGCAATA-3'; shCOBRA1-2A: 5'-GACCTTCTGGAGAAGAGCT-3'. For the negative control, the EGFP-targeted shRNA sequence (5'-GAACGGCATCAAGGTGAAC-3') was cloned into both the puromycin- and neomycin-resistant pSUPER.retro constructs. For verification of the BRCA1 knockdown effect, the following siRNA oligos were used in a transient transfection experiment: BRCA1-DO4 (5'-GCAGATAGTTCTACCAGTA-3'); BRCA1-DO7 (5'-GAAGGAGCTTTCATCATTC-3').
Viral supernatants were prepared and used to infect T47D cells as described previously [5]. Stable pools were selected with either 10 μg/ml puromycin for one week, or 800 μg/ml neomycin for two weeks. To generate the COBRA1/BRCA1 double knockdown cells, the BRCA1 single knockdown pool was first generated and selected in puromycin-containing medium. The selected cell pool was further infected with the shCOBRA1-expressing virus, and a second selection was carried out for two weeks in the presence of both puromycin and neomycin.
To evaluate the expression of BRCA1 and COBRA1, whole cell extracts were prepared in SDS sample buffer containing a cocktail of protease inhibitors. Protein concentrations were determined by the BCA protein assay reagent (Pierce). Approximately 30 μg of total protein was used for 5% (for BRCA1) or 10% (for COBRA1) SDS-PAGE. The proteins were detected by incubation with antibody directed against: anti-BRCA1 (Ab1 from Calbiochem), anti-tubulin (Calbiochem), or anti-COBRA1 [5]. Antibody binding was visualized using chemiluminescence (SuperSignal West Pico, Pierce) according to the manufacturer's directions.
shRNA-expressing T47D cells were grown to 70% confluency and harvested for total RNA. Duplicates of the following cell lines were subjected to microarray study using the human gene array chips (HgU-133A) from Affymetrix: shEGFPpuro+shEGFPneo, shBRCA1puro+shEGFPneo, shEGFPpuro+shCOBRA1neo, shBRCA1puro+shCOBRA1neo.
A total of 287 genes were found to be differentially regulated by BRCA1 and COBRA1, using the LPE test with statistical significance of p-value 0.003 [14]. The LPE test is specifically designed for small-sample microarray data analysis by significantly strengthening statistical power based on an advanced error pooling method at each local intensity range where signal-to-noise ratio is similar among different genes. Thus, by employing LPE, we were able to identify differentially regulated genes on our duplicated microarray data with statistical rigor.
Hierarchical clustering analysis was further performed with the 287 genes selected in the previous analysis, using Pearson correlation as a measure of similarity between genes and the average linkage (average distance) as a clustering allocation algorithm. In this clustering analysis, genes with low-intensity expression patterns were found to be closely clustered at the left-hand side of the heat map in Fig. 1B. Note that high expression intensities are represented by red, low expression intensities by green, and medium intensities by black.
T47D cells were grown to 70% confluency and total RNA was extracted with TRIzol Reagent according to the manufacturer's instructions (Invitrogen, Carlsbad, CA, USA). The concentration and purity of the RNA were determined spectrophotometrically at 260 and 280nm. Approximately 1 μg of RNA was reverse-transcribed using ImPromp-II reverse transcription system (Promega, Madison, WI, USA). The RNA extraction and reverse transcription kits used for RNA/cDNA preparation for the clinical samples were purchased from AbGene and Sigma, respectively.
The Affymetrix microarray results were verified by real-time RT-PCR for those genes shown in Fig. 3. Primer Express software (Applied Biosystems, Foster City, CA, USA) was used to design primers that covered two neighboring exons. Primer sequences are provided in the Table 1. An ABI 7300 real-time PCR machine was used for the quantitative real-time PCR analysis. Standard curves were generated by a serial dilution of cDNA and relative mRNA levels were measured. Expression levels were normalized against β-actin. Results shown were representatives of at least three independent experiments.
Microarray analysis of gene expression profiles in COBRA1 and/or BRCA1-depleted breast cancer cell lines. A. Immunoblot analysis showing the decreased expression of BRCA1 and COBRA1 protein in the shRNA-expressing T47D cells lines. Whole cell extracts were prepared from the following cell lines: shEGFPpuromycin+shEGFPneomycin (E); shBRCA1puromycin+shEGFPneomycin (-B); shEGFPpuromycin+shCOBRA1neomycin (-C); and shBRCA1puromycin+shCOBRA1neomycin (-B/C). Parental T47D cells (WT) were also included for comparison. Protein expression levels were analyzed using antibodies against BRCA1(top panel), COBRA1(middle panel), lamin A/C (bottom panel). Lamin was used as a loading control. B. Hierarchical clustering analysis of the 278 COBRA1 and/or BRCA1-regulated genes. Data from the duplicates of four knockdown cell lines are shown. High expression intensities are represented by red, while low expression intensities are represented by green. Black indicates medium intensities. In the tree dendogram on the left side of the plot, genes with similar expression patterns are closely linked in lower levels. On the right side, annotations of corresponding genes were added in the order of Affymetrix probe ID, locus ID, gene symbol, and chromosome location.
Primers used in the qRT-PCR for verification of COBRA1/BRCA1-regulated genes.
|Genbank Accession No.
|Gene name
|Primer Forward (5'_3') Primer Reverse (5'_3')
|S100 calcium binding protein P
|Tissue inhibitor of metalloproteinase1
|Mitogen-activated protein kinase kinase kinase 12
|Gamma-aminobutyric acid (GABA) B receptor, 1
|Apolipoprotein D
|Apolipoprotein D
|Serine protease inhibitor, Kazal type, 5
|Inhibitor of DNA binding 1
|Neuroblastoma, suppression of tumorigenicity 1
Given the known function of COBRA1 in transcriptional regulation, it was reasonable to speculate that reduced COBRA1 expression might lead to aberrant gene expression, which in turn could promote tumor recurrence and metastasis. Decreased COBRA1 expression may also compromise the potential functional interaction between COBRA1 and BRCA1. To test these intriguing possibilities, we stably knocked down COBRA1 and BRCA1 either separately or together in the ER-positive T47D breast cancer cell line. As a negative control, we also expressed small hairpin RNA (shRNA) specifically targeting at enhanced green fluorescent protein (EGFP). Immunoblot analysis was carried out to examine the expression levels of BRCA1 (Figure 1A, top panel) and COBRA1 (middle panel) in these cell pools. When compared with the parental T47D cells (lane 5) and the EGFP-shRNA control cells (lane 1), both COBRA1 and BRCA1 shRNA sequences significantly reduced the expression levels of the corresponding proteins in the single (lane 2 and 3) and double knockdown cells (lane 4). Importantly, the BRCA1 level was not affected by the expression of COBRA1-specific shRNA, and vice versa. Thus, expression of BRCA1 and COBRA1 is not dependent of each other.
Total RNA samples from biologically duplicated cell lines of control (E), BRCA1 knockdown (-B), COBRA1 knockdown (-C), and BRCA1-COBRA1 double knockdown (-B/C) were isolated and subjected to microarray analyses using Affymetrix HG-U133A GeneChipsTM with ~23K human gene transcripts. The LPE test was applied to identify the differentially expressed genes between the control and each of COBRA1 and/or BRCA1 knockdown cells. The program revealed 287 genes that were significantly affected by either BRCA1/COBRA1 alone or double knockdown, respectively (p<0.003; Supplemental Material).
A hierarchical clustering analysis of the 287 genes was carried out to further interrogate the relationship between BRCA1- and COBRA1-mediated gene regulation (Fig. 1B). A careful examination of the heat map revealed some interesting expression patterns among the 287 genes. In particular, depletion of BRCA1 or COBRA1 alone affected a large number of commonly regulated genes (a total of 151 genes), strongly suggesting a significant degree of functional overlap between the two proteins. Gene Ontology Analysis indicates that the BRCA1 and COBRA1-regulated genes are enriched with those involved in cell cycle control, cell proliferation and development, cell death, and cancer (Fig. 2).
Following the microarray study, we performed quantitative RT-PCR (qRT-PCR) analysis to validate the effects of BRCA1 and COBRA1 on gene expression. The genes that were chosen for further verification include those that have been previously implicated in breast cancer, such as S100P [15] and TIMP-1 [16]. We first confirmed the changes in gene expression by using the same RNA prepared for the microarray analysis. As shown in Fig. 3, the expression level of all eight genes was altered by BRCA1/COBRA1 knockdown in a manner that was consistent with the microarray data (Supplemental Material). For example, expression of S100P was largely affected by COBRA1 or BRCA1 knockdown alone, respectively. Depletion of BRCA1 on top of COBRA1 did not lead to additional changes in mRNA abundance (compare "-C" with "-B/C" for S100P). On the other hand, the mRNA level of TIMP1 increased most substantially by the simultaneous knockdown of COBRA1 and BRCA1 (e.g. compare column "–B" and "–C" with "–B/C" for TIMP1), suggesting the involvement of both proteins in gene regulation at these loci. We were also able to verify the effect of COBRA1/BRCA1 knockdown on several down-regulated genes including SPINK5, ID1, and NBL1 (Fig. 3B).
Among the BRCA1/COBRA1-coregulated genes, TIMP1 has been reported to be over-expressed in breast cancer [16,17] and especially in patients with advanced breast cancer [18], thus serving as a potential predictor for poor prognosis [19]. A recent study has also correlated TIMP1 expression with breast cancer that is metastasized to liver [20]. To confirm the TIMP1 results obtained from the stable knockdown cells, we used two different BRCA1-specific siRNA oligos (DO4 and DO7) to transiently knock down BRCA1 in COBRA1-depleted T47D cells. As shown in Fig. 4A and 4B, BRCA1 knockdown by either oligo significantly increased TIMP1 expression. This result alleviates the concern over the possible secondary genetic changes that might have occurred in the stable BRCA1 knockdown cells due to the impaired DNA checkpoint function. It has been reported that TIMP1 expression is estrogen-stimulated [21]. Consistent with the published finding, we observed a modest (2-3 fold) stimulation of TIMP1 by estrogen treatment in both control and BRCA1/COBRA1-knockdown cells. Intriguingly, both estrogen-dependent and independent transcription of the TIMP1 gene was markedly elevated by the COBRA1/BRCA1 knockdown (Fig. 4C).
Gene ontology of the COBRA1/BRCA1-regulated genes. The Ingenuity Gene Ontology Analysis tool is used to identify several biological pathways that are relatively enriched with COBRA1/BRCA1-regulated genes.
Verification of the microarray results by real-time RT-PCR. Four different cell lines are compared: shEGFP (E; dark gray bars), shBRCA1 (-B; black stripe bars), shCOBRA1 (-C; white bars), and shBRCA1+shCOBRA1 (-B/C; black bars). The selected genes for verification include those that are up- (A) and down-regulated (B) by the depletion of BRCA1 and COBRA1.
Further verification of the effect of BRCA1 knockdown on TIMP1 transcription. (A-B). Transient knockdown of BRCA1 using BRCA1-specific siRNA oligo (DO4 in A and DO7 in B). Mock transfection and a luciferase-specific siRNA oligo were included as controls. siRNA oligos were transfected into EGFP(E) or COBRA1(-C) stable knockdown T47D cells. The immunoblots in Fig. 4A show the extent of BRCA1 depletion in the transient transfection experiment. (B). Control or BRCA1/COBRA1 knockdown cells were starved in medium containing charcoal-stripped serum. Vehicle or estradiol (E2; 10nM final concentration) was added for 24 hr, and RNA was harvested for qRT-PCR analysis of TIMP1 mRNA abundance.
The effect of BRCA1 knockdown on TIMP1 expression is consistent with the previously published work that indicates elevated TIMP1 expression in BRCA1 mutation-associated ovarian tumors and "BRCA1-like" sporadic tumors [22,23]. The same group also showed that ectopic expression of BRCA1 in a BRCA1-deficient breast cancer cell line resulted in reduced TIMP-1 expression. In an independent study, ribozyme-mediated down-regulation of BRCA1 in a melanoma cell line also resulted in increased TIMP1 expression [24]. Taken together, TIMP1 may serve as one of the molecular links between BRCA1-mediated transcriptional regulation and tumor metastasis.
Many of the COBRA1-regulated genes identified in our previous and current work have been well documented for their roles in advanced breast cancer. For example, we recently demonstrated that COBRA1 is recruited to, and regulates the activity of, the promoters of the trefoil factor (TFF) gene family (TFF1-3) [6]. TFF3 was also identified as a COBRA1-regulated gene in the current study (Supplemental Material). It is worth noting that both TFF1 and TFF3 are associated with breast cancer metastasis to bone [25] and advanced prostate cancer [26]. Similar association with breast cancer metastasis has also been reported for a number of COBRA1-regulated genes identified in the current microarray study, including S100P [27], MUC1 [28], and TIMP1. Combined with the finding that reduced COBRA1 expression is associated with metastatic and recurrent breast cancer [29], the effect of COBRA1 knockdown on gene expression lends further support to the notion that COBRA1 plays an important role in suppressing breast cancer development.
One of the most intriguing findings of the current work is the significant overlap of gene expression profiles between the BRCA1 and COBRA1-depleted cells. The data in the current study strongly suggest a joint action of COBRA1 and BRCA1 in modulating transcription of a group of common target genes. Both COBRA1 and BRCA1 are known to be associated with the RNA polymerase II (RNAPII) holoenzyme [2,10,13,30,31] as well as other factors involved transcriptional elongation and RNA processing [3,4,12,32,33]. In light of the physical association and functional commonality between COBRA1 and BRCA1, we propose that these two proteins may intimately communicate with each other in modulating the movement of the transcription elongation complex for a common set of target genes.
Given the large overlap of the gene expression profiles in the COBRA1 and BRCA1-depleted cells, it is interesting to note that BRCA1-associated tumors are usually diagnosed as high-grade infiltrating ductal carcinoma, and that patients with BRCA1-associated breast tumors tend to have a poor prognosis [34]. Moreover, a recent report suggests a high incidence of brain metastasis in BRCA1-associated cancer cases [35]. These clinical features of BRCA1-associated tumors are reminiscent of the association of low COBRA1 expression with metastatic breast cancer [29]. It is conceivable that loss of COBRA1 and/or BRCA1 may result in aberrant expression of a common group of cancer metastasis-associated genes, which could account for the clinical outcomes in both cases.
A significant proportion of the genes in the current microaray study are down-regulated in the COBRA1 and BRCA1 knockdown cells. This is somewhat unexpected as COBRA1 is best known for its role in transcriptional repression. It is possible that expression of this group of genes is indirectly affected by COBRA1 knockdown. Alternatively, COBRA1 might act as a bi-functional protein to both repress and activate transcription. While more mechanistic studies may shed light on this issue, it is worth pointing out that COBRA1 is capable of inducing large-scale chromatin unfolding when targeted to specific regions of the mammalian genome [1]. Conceivably, the activity of COBRA1 in chromatin reorganization could account for a more direct role of COBRA1 in gene activation.
In conclusion, combination of shRNA-mediated knockdown and gene expression profiling points to a large degree of functional commonality between COBRA1 and BRCA1 in transcriptional regulation. This finding provides functional relevance to the previously identified physical association between the two proteins. Furthermore, altered expression of multiple breast cancer-associated genes in the COBRA1/BRCA1 knockdown cells offers molecular insight into the roles of COBRA1 and BRCA1 in progression of breast cancer.
Primers used in the qRT-PCR for verification of COBRA1/BRCA1-regulated genes.
The work was supported by National Institutes of Health grant (DK064604 and CA93506), and DOD Breast Cancer Research Program Award W81XWH-04-1-0519 (S.E.A).
The authors have declared that no conflict of interest exists.
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27. Wang G, Platt-Higgins A, Carroll J, de Silva Rudland S, Winstanley J, Barraclough R, Rudland PS. Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patients. Cancer Res. 2006;66:1199-1207
28. Rakha EA, Boyce RW, Abd El-Rehim D, Kurien T, Green AR, Paish EC, Robertson JF, Ellis IO. Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer. Mod Pathol. 2005;18:195-304
29. Sun J, Watkins G, Blair AL, Moskaluk C, Ghosh S, Jiang WG, Li R. Deregulation of cofactor of BRCA1 expression in breast cancer cells. J Cell Biochem. 2007 [Epub ahead of print]
30. Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD. BRCA1 is a component of the RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A. 1997;94(11):5605-10
31. Anderson SF, Schlegel BP, Nakajima T, Wolpin ES, Parvin JD. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat. Genet. 1998;19:254-256
32. Kleiman FE, Manley JL. Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Science. 1999;285:1329-1339
33. Kleiman FE, Manley JL. The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. Cell. 2001;104:743-753
34. Narod SA, Brunet JS, Ghadirian P, Robson M, Heimdal K, Neuhausen SL, Stoppa-Lyonnet D, Lerman C, Pasini B, de los Rios P, Weber B, Lynch H. HBCCS. Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Hereditary Breast Cancer Clinical Study Group. Lancet. 2000;356:1876-1881
35. Albiges L, Andre F, Balleyguier C, Gomez-Abuin G, Chompret A, Delaloge S. Spectrum of breast cancer metastasis in BRCA1 mutation carriers: highly increased incidence of brain metastases. Ann Oncol. 2005;16:1846-1847
Correspondence to: Rong Li, PhD, Professor, Department of Molecular Medicine, Institute of Biotechnology, 15355 Lambda Drive, University of Texas, Health Science Center at San Antonio, San Antonio, TX 78245. Tel: 210-567-7215; Fax: 210-567-7324; Email: lir3edu
Received 2007-11-6
Accepted 2007-11-22
Published 2007-11-26


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KCDK-E: Turkish invasion takes place with Western approval
KCDK-E: Turkish invasion takes place with Western approval
KCDK-E: Turkish invasion takes place with Western approval
The Kurdish European Confederation KCDK-E pointed out that the new invasion and annexation aggression of the Turkish army in Southern Kurdistan is coordinated with the USA and Europe.
The Turkish army launched an air and ground operation in the guerrilla areas of Metina and Avashin last night, and the area of operations was expanded to the Zap region today. The Kurdish Democratic Social Congress Europe (KCDK-E) pointed out that the invasion in Southern Kurdistan (Northern Iraq) is coordinated with the United States and Europe. A statement released by the association today said:
"The Turkish occupying army is carrying out intensive bombardments from the air and on the ground, and civilian areas are also being bombed. Without distinguishing between civilians and guerrillas, the Turkish state wants to perpetrate a Kurdish genocide. The attack aims at annexation and happens with the consent of the USA as well as Europe and international powers. The Kurdish people's ideas of a free Kurdistan are intended to be destroyed by this attack."
For the Kurdish people it is a question of existence, explains the KCDK-E and calls for immediate protests: "To denounce the hypocritical attitude of the USA and Europe, the Kurdish people must mobilize. We must rise up everywhere and take to the streets to denounce the fascist Turkish regime and dictator Erdogan for their war crimes and goal of occupation and annexation. As KCDK-E, we call on the Kurdish people to defend their country and all revolutionary and democratic people in Europe and around the world to join street protests against this invasion and annexation aggression."


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Nyle Water Heating Systems is growing fast due to a surge in demand for energy-efficient heat pump technologies. We're pleased to announce that our factory improvement project that kicked off early this year is almost complete. When finished, the major upgrade at our Brewer, Maine facility will double the manufacturing and office space, increase production efficiencies and enhance our new product development capabilities.
As part of the project, Nyle Systems has been purchasing production equipment to increase capacity and reduce unit costs, including: a copper pipe bender; a pipe reducing machine; a press break; and a shear. We're also building a larger paint room; installing electrical & gas lines; and installing an air ventilation system for the expanded welding department.
Continuous improvement is a key part of our mission, so we're advancing our research capabilities, too, including a new food drying test laboratory and a test chamber for new product development.
The project is being paid for in part by a $142,981 grant from the Maine Technology Institute. This grant is allowing us to invest even more in our business at a critical stage in our growth, which will lead to more good-paying jobs in our community. Onward and upward!


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Just a few kilometres away from the town you will discover the best beaches and coves of Majorca Island.
This zone of the Island is very well-known for its natural park Cala Mondragó. It is a privileged site that is characterised by its fine white sandy coves which compose an emblematic and typical landscape of Eastern Majorcan.
Cala Ferrera, S'Almunia, Es Caló des Moro, Cala Llombards, Es Trenc, Es Carbó… are all authentic Majorcan treasures. At S'Hotelet we will facilitate you with all the information that you need to enjoy the sea: excursions to the natural park Cabrera, a ride in a golondrina (a small boat), recreation boat rental, diving, fishing, sailing…
Santanyí is perfectly located between the countryside and beaches. You will easily be able to plan days with multiple activities.


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|I didn't know which one you'd be using to see this first so I sent one to all of your "alts" as us computer geeks say. Grow UP! And by the way...I am going to get married to Tiffany, I am going to continue to allow HER to feast on MY blood. To allow her to cut me as deep as she wants. She doesn't need a bitch like you to put her down because you have nothing better to say except, "WHAT THE HELL WERE YOU THINKING!? ARE YOU STUPID?!" You fucking Jehovah's Witnesses...I know what they are about. All they do is think their religion is right, they rule, and there's is a paradise. Well guess what. Your expectations of your daughter learning from you and realizing you were right when she gets older are dead.. She loves me; I love her. PERIOD! I'm glad Hitler killed all thos Jehovah's Witnesses. You should die to you lesbian. Yes. Even you daughter knows of your foursome and other lesbionic experiences..Haha. I laugh at you stupidity. Soon enough your blood will be splattered all over your own face. Looking up at me crying begging me to let you go. I'll smile at you and say, "Fuck you. Vampir rules." BY THE WAY! DON'T EVER SAY BOMBINESS AGAIN! YOU FUCKER!
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About Us
Dedicated to your health.
We are an Independent Pharmacy here to serve your needs!
We provide the following services to make your life easier:
We NOW accept MOST insurance plans. There have been a few glitches as we've signed up for insurance plans, but we think we have most of that sorted out now. Not sure if we accept your insurance? Just ask.
Delivery--We deliver. Ask us if we can bring your medicine right to your door.
Immunizations--Get your flu or pneumonia shots here. Elaina and our other pharmacists and pharmacy students can adminster vaccines, including hepatitis A and B, tetanus, diptheria, and pertussis for adult patients. Ask Elaina if you have any questions about a particular vaccine.
Medication Therapy Management (MTM)--A pharmacist or pharmacy student will sit down and review your medications with you.
Personalized Service and Counseling: You can always talk to a pharmacist in person--Elaina--about your medications or any questions you may have about your health.
We're Social--Follow us on Facebook to keep up on the latest things happening in the store.
Online Access to your prescriptions: It is our commitment to provide you with exceptional service both in the pharmacy and online. We are pleased to announce that you can now access your prescriptions online - 24/7!
Additional services.
Elaina Zuelke - Pharmacy Manager
Elaina graduated with her PharmD from Ohio Northern University in 2019. She has known she wanted to be a community pharmacist since she was in the eighth grade.
When she's not at the pharmacy, Elaina enjoys biking, reading, and spending time with her husband, Patrick.
Elaina is so excited to serve the community of West Jefferson!
"Providing excellent patient care is the main priority here at Happy Druggist Pharmacy | West Jefferson."
Elaina Zuelke
Pharmacy Manager


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ATLANTA—As gasps of horror resonated throughout the crowd of reporters, CDC director Robert Redfield announced Thursday that the spread of coronavirus was under control while his nose slowly transformed into a pangolin snout. "I want to assure the public that we acted quickly and aggressively to halt the progress of this virus, and now the threat is neutralized," said Redfield, tugging at his shirt sleeves to conceal the hard scales that were forming along his clawed hands, his thin tongue snaking out of his narrowed muzzle to wrap around the microphone stand. "We've prevented a global pandemic and—argh, it hurts—Americans can rest assured Covid-19 is nothing to worry about. Oh God, what's happening to me? Without our hardworking medical professionals, this could have ballooned into a nationwide crisis with far-reaching consequences. I do, however, want to stress that I need ants. Ants! Me want ants." At press time, health officials were urging Atlanta residents to wash their hands if they had recently come into contact with an enormous feral pangolin.
We may earn a commission from links on this page.
CDC Issues Dire Warning That Nick Cannon Is Feeling Horny


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TAOV Strawberry: Look, I love a good product description as much as the next person - but it's TAOV Basics Strawberry. There's not much I can say... It's... well it's a bloody Strawberry! Great flavour, better prices!
- VG/PG Ratio - 50% VG / 50% PG
- Bottle Size - 10ml
- Volume - 10ml
- Discounts: 3 for £10
These juices are designed for mouth to lung devices (coils over 1ohm resistance). Using these juices in sub ohm devices can lead to leakages, spitting and a generally harsh vaping experience. If in doubt, please Contact Us!
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.


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France-based streaming music service Deezer announced on Wednesday that it has teamed up with Sonos to offer a High-Resolution Audio (HRA) service here in the United States. Called Deezer Elite, this service will, for now, only be offered by Sonos and Home Integrators. However, the service is expected to roll out globally in the near future. Deezer is the second largest music streaming service across the globe.
According to the announcement, Deezer Elite subscribers will have access to 35 million tracks. They will also be able to stream the music in the FLAC (Free Lossless Audio Codec) format, or at a standard of 1,411 kbps or higher. Customers who sign up for a full year of service will get Deezer Elite for $9.99/month, 50 percent off the regular price ($19.99/month).
"Deezer defines HRA as the same or higher sampling frequency and bit depth of a physical CD, which is 16-bit/44.1kHz or 1,411 bitrate (kbps), captured in a lossless format like FLAC, WAV etc," the press release said. "With the vast majority of music listeners using MP3 format (320 kbps or lower), the 1,411 bitrate standard represents a significant jump in music quality."
Some of Deezer Elite's features include 24/7 customer service, on-demand playlist recommendations, social networking spanning comments and music sharing, the ability to listen to Deezer Elite on any device, and synching the customer's past music history from any service.
Deezer revealed on Wednesday that it offers streaming music to 182 countries, 16 million monthly active users and 5 million paid subscribers. Deezer provides more than 30,000 radio channels on devices like smartphones, tablets, smart TVs, stereo systems, consoles and more. Deezer was launched back in August 2007.
The Deezer Elite music subscription service will be launched in the United States as a beta on September 15. Customers will be provided with a 30-day free trial. According to Sonos, customers can get Deezer Elite by opening any Sonos Controller, opening "Add Music Services," and then opening "Sonos Labs."
Tyler Goldman, CEO of Deezer North America, said that audio enthusiasts no longer have to choose between high quality music and streaming music. "We are focused on super-serving the needs of underserved market segments to continue to grow the music streaming category," he said.
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I'm sick of my roommates crap
SEALGIRL19 - Oct 8 2016 at 16:24
Member since Apr 2016
I'm a female and I live with two male roommates, one of which is a ex. Yea I know it sounds messy but I'm living with him so I can save money, finish many last year of school, and not leave the city I'm currently in yet. At first I was willing to leave since I didn't have a job and I didn't know anyone that could've housed me until I get back on my feet. So he offered the idea of moving into a two bedroom with his friend until we can get back on our feet. We all moved into a two bedroom last month. I covered the first months rent and my portion of second months with money I had save. My ex has a decent paying job and he's able to pay his portion of the rent. Our third roommate however has no money for anything at the moment. I've recently received a part-time job even though it wasn't the best paying it's something to put in my pocket for now plus I go to school full-time. Roommate #3 however, turns down job offers because he feel that they pay too low for him, hurt his back, the job distance is too far,etc. So there's a lot of stress on my ex for paying that third roommate's portion of the rent. ( Which my ex said that roommates will be paying back once he gets a job.) We also pay utilities which is gas and light. My ex thought it would be a good ideal if me and roommate #3 put each bill in our named so it could motivate us to find a job quicker. I put my name on the light bill and roommate #3 put his in gas. This part is escential to my gripe with roommate #3. So currently we are nearing our third month in this two bedroom apartment. I have school and work, my ex has work, and roommate #3 has no job and just stay home, clean, play video games, and look for jobs ( allegedly). Once I talked to my ex about roommate #3 basically expressing my concerns about him not having a job and how I feel that he's not taking the job hunting seriously because he keep turning down job offers for whatever reason, coming up with reasons he can't work the jobs me or his friend recommend to him, and when I come home from work/school he's always playing videogames. I vented those feelings to my ex and he later went to roommate #3 and told him I said I felt he wasn't looking for jobs and he turned that into a house meeting about communication. Part of me feels a little betrayed and upset because he twisted my words and told roommate #3 everything I told him without letting me know first. So in the house meeting I was coming from math class and I was already frustrated because I didn't do well on a math test. So to come home to that it made me really irritated. Roommate #3 tried to prove to me that he was applying for jobs by showing a list of places he's been applying to which I could care less about because there are no results coming from them. I told my ex that he twisted my words when he said I said I felt roommate #3 wasn't looking for jobs and he choose the wrong time to do what he did for the sake of communication. Back to the utilities thing when we applied for utilities roommate #3 was reluctant because he still had his gas bill connected his old place so he had to go through the process of switching it over. My light bill is all set up and that's squared away. The thing that bothers me with the light bill is that roommate #3 is home all day wasting electricity while me and my ex are out a working. So Lord knows how bad that this light bill is going to look like. Plus he has no money for the gas bill so guess who has to take care of that. Granted he said he's paying back for what he owes but what can he pay back with no job? I'm getting flack from my ex about how he has to front for most of the bill for choices he made and I'm constantly getting guilt tripped and lectured while roommate #3 is on his butt all night playing videogames and doing nothing in my eyes. I'm just frustrated and wanted to vent because all the people I thought were friends are garbage and I can't trust them for anything. Right now I'm regretting not leaving the city even though I'm close to my degree. Now I'm stuck having to endure this until my lease is up or we get tired of each other.
I'm sick of my roommates crap
MANALONE - Oct 9 2016 at 23:09
Member since Dec 2013
Given the circumstances, if you're determined to finish your degree, then you will put up with situation but you won't be saving money. Going by your post, your 3rd room mate will drain all of your money. His type always have an excuse and when he finally gets a job, don't be surprised if you see no or very little money being paid back. Your ex is manipulating you and he needs to understand that his friend is his responsibility and he can't expect you to assist him carry his friend just because you guys share a lease. You need to make this very clear to him if you intend to stay. It doesn't matter what the circumstances were when you first discussed moving in together, what does matter is that everyone who shares a lease needs to contribute and have the means to contribute...otherwise the whole excercise is pointless. Your ex needs to discuss this with his friend and give him some flack about not paying his share or getting a job urgently, rather than lecturing and guilt tripping you.
I'm sick of my roommates crap
ALTREAL - Oct 12 2016 at 07:53
Member since Aug 2015
I wonder why it was determined that you would be the one to pay the light bill. I mean, that's the electric bill, right? Seems to me you all would use that utility a lot. I think it would have been more fair if you all paid for everything together. Also kind of cruddy that you have a 2-bedroom place. I'm guessing one of you sleep in the living space? Hopefully, they at least let you have one of the rooms. If you want my honest opinion, you should either get out of that lease, or leave once the lease is up. Either find a better living situation there, or else try to get back home. Sometimes places will let you leave the lease if you can find someone to immediately replace you. If you decide you want to leave for sure, it is something you can ask about. It's cool that your ex gave you this opportunity, but he has you stuck in a difficult situation whether or not he realizes that. If he loses his only reliable tenant, he might finally realize that his buddy isn't doing very well at taking care of his share of bills. You could probably just tell him you feel awkward about living with two guys, or something. If he was a decent ex then he will understand it isn't working out for you. It's up to you whether you can manage until you finish school. Considering the money you've paid out to go to school, you might want to try to hang in there a bit longer for that, at least.
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By Pamela Kan-Rice, UC Agriculture and Natural Resources
Keeping current on government regulations, agricultural marketing news and crop research advances can be challenging for California farmers, especially for those who speak English as a second language.
Hmong farmers in the San Joaquin Valley can tune in at 2 p.m. on Tuesday afternoons to listen to farm-related news delivered to their radios in their native language from Michael Yang, UC Cooperative Extension small farms and specialty crops advisor for Fresno County.
For the past 22 years, Yang has hosted the one-hour Hmong Agriculture Radio Show on KBIF 900 AM in Fresno to promote prosperity in the largely immigrant, small-scale Southeast Asian farming community. Yang provides advice on crop production and marketing.
"Fresno County has a large number of small and diversified farms; we have over 1,300 Southeast Asian farms and over 900 are Hmong farmers, according to a survey we did in 2007," Yang said. "I used to help 250 to 300 farmers every year, in the past couple of years it's grown to about 400 farmers."
Yang not only speaks their language, he shares their culture and history. After his father was killed for assisting the U.S. during the Vietnam War, Yang, his mother and three younger brothers spent 4 years of his childhood fleeing on foot through the jungles of Laos, subsisting on vegetation and wildlife, to reach safety in Thailand. The refugee family eventually made it to Fresno, where they took up farming.
The Hmong farmers grow Asian specialty crops including eggplant, lemongrass, long bean, squashes, bittermelon and moringa that they sell at farmers markets or to restaurants. Connecting Southeast Asian farmers to sell their produce at farmers markets has been a vital role for Yang, who serves as a translator and cultural interpreter between the immigrant farmers and farmers market managers. He explains the requirements for participating in the farmers markets and helps the farmers with paperwork and communication. Some growers drive as far as San Diego to get a higher price for their produce; the price can be three times as high at farmers markets in larger cities compared to Fresno.
Sales of Asian specialty crops grown by Hmong and other Southeast Asian farmers in Fresno County are valued at about $17.5 million annually, according to the Agricultural Commissioner of Fresno County.
Although Yang and colleague Ruth Dahlquist-Willard, UC Cooperative Extension small farms advisor, offer workshops and field days to share information, the radio show is an important information source because farmers can listen to the show while they work in the field. Because Hmong Agriculture Radio Show is such a critical tool for bilingual outreach, Dahlquist-Willard continually seeks grants to pay the $75 per show to the radio station. Of the 69 Hmong farmers who responded to a 2015 UC Cooperative Extension survey, 80% said they regularly listened to Yang's radio show.
Read more at this link on the UC ANR web site
Video with Michael Yang working with a Hmong farmer to explain how CDFA's SWEEP program benefits his farm.


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Dog Food Advisor › Forums › Editors Choice Forum › Best for Weight Gain
October 12, 2016 at 12:32 pm #90663 Report AbuseKristin SMember
I am trying to put weight in my two year old mutt. She is thin and always has been. I hate HATE seeing her ribs and her spine. She is about 60-65lbs and needs to gain at least 5 lbs and would probably do okay with 10lbs. She's very active and unfortunately, a very picky eater. I am going to start feeding her all RAW but I'm pregnant and can't stomach the raw food right now.
Can anyone recommend a high quality kibble for a highly active dog??
Thank you very much!!October 12, 2016 at 8:52 pm #90675 Report AbuseMaria KMember
Acana Regionals Wild Atlantic is a good oneOctober 13, 2016 at 6:12 am #90688 Report AbuseLeslie WMember
My 9 year old Yorkie was having problems maintaing her weight so I checked out Dog Food Advisor and based on info there decided to give Natures Instinct Ultimate Protein (chicken) a try. Her weight is back up and is maintaining well.October 13, 2016 at 2:16 pm #90696 Report AbusezcRileyMember
Dr. Tim's Pursuit Active Dog Formula Dry Dog Food or Orijens Puppy Formula.
The standard is when the loss exceeds ten percent of normal body weight (and when it is not due to fluid loss).
Fecal studies to look for chronic intestinal parasites
Complete blood count (CBC) to look for infection, inflammation, leukemia, anemia, and other blood disorders
A biochemical profile that will evaluate kidney, liver, and pancreas function, and the status of blood proteins, blood sugar, and electrolytes
- The forum 'Editors Choice Forum' is closed to new topics and replies.


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|Souvenirs of the move and recent work.
Last night all the work of late caught up with me. I went to bed at 8:00 pm and slept solidly until 5:00 am this morning. It felt great to finally get a long, deep sleep. It's a sign of slowly believing this place is home.
And I've discovered the miracle of electric heat. I'm already sick of heating exclusively with wood. I'm going to use electricity during the days and the fire in the late afternoons/evenings. There are five baseboard heaters but I only use two at a very low setting. It's so easy!
Yesterday my newly fixed guest toilet flooded and last night my plan was to chill with Netflix and Leon but my Netflix access was denied. Then this morning my email wouldn't work after working yesterday. As Gilda Radner, whom I adored, used to say: "It's always something."
Everything is working now except the toilet and I'm going to try to fix that tomorrow. Today I'm stuck at home waiting for Telus to install a landline. I'm using my time to figuring out garbage collection — I've sent an email to the Regional District for instructions — and where to find and how to access my surface mail.
On the plus side: My bird feeder is hugely popular — particularly with Steller's Jays. My yard is alive with birds — even a huge, gorgeous Pileated Woodpecker and his mate. I hung the feeder on the side of the house where I could see it every day; it's away from the backyard where all my life will be in the summer. And this morning I hung my hummingbird feeder.
And I'm on my second pie from the pie lady whom the local government is trying to shut down.
I took the tangled and broken venetian blinds off the windows and cleaned the glass and what a difference it makes. To celebrate I'm on my second pie from the pie lady (whom the local government is trying to shut down).
I still can't talk to strangers. I'll admit to being a little disappointed by that. Perhaps I was naïve but I did hope there'd be an immediate improvement. Sigh.
The Telus guy came and was as friendly and chatty as the Shaw fellow. I'm really impressed by the friendliness of everyone.


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Craig McDermott gave this bad bill a mention in his "This Week" post yesterday:
Ways and Means, Monday, 2 p.m., HHR3. On the agenda: a striker to SB1088, listed subject as "empowerment scholarship accounts; eligibility" (text not available as of this writing). This one has popped up before as its own bill; it's all about expanding school vouchers "empowerment scholarships."
The Arizona School Boards Association has an action alert out this morning:
The House Ways and Means Committee is attempting to use a strike-everything amendment to pass what could be the largest voucher expansion yet in the final days of the legislative session. Please sign in to the Request to Speak system and make your voice heard on this important bill by Monday March 16th at 2:00PM.
This bill, SB1088 (formerly INCOME TAX BRACKETS; INFLATION INDEX now, s/e EMPOWERMENT SCHOLARSHIP ACCOUNTS; ELIGIBILITY), would open a huge number of new accounts for a program that lacks any effective oversight. Even the Department of Education is concerned that they cannot prevent fraud and abuse with these vouchers.
After you've logged in, click on "New Request" on the left hand column, search either by the bill number below or by selecting the House Ways and Means committee. When you see the bills listed, make sure to click "Add Request" to be able to leave your comment. Register your position, select "No" where it asks if you'd like to testify, and leave a comment in the box. Do not forget to list yourself as a school board member, parent, or constituent when leaving your comment!
Once you've left a comment through the Request to Speak system, make sure to email the legislators on the House Ways and Means Committee using our action form and share with your friends!
You know what to do!