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AAVnerGene Inc.
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AAV Gene Therapy
AAV Biology
Overview of gene therapy market
The first set of promising gene therapies were brought to a halt in 1999 after the death of Jesse Gelsinger from an immune reaction to the vector transporting a gene therapy for his metabolic disorder, and the development of leukemia by multiple patients—including one who died—in trials that ran between 1999 and 2002 for X-linked severe combined immunodeficiency (SCID-X). In the years since, better clinical and scientific understanding of the safety risks have enabled the first wave of clinical success. This has included a better understanding of immunogenicity and integration patterns of viral vectors as well as improved technologies and modified delivery mechanisms. Manufacturing improvements have included new chemistry, manufacturing, and controls regulations and improved accuracy of oligo synthesis.
More than 150 investigational new drugs applications were filed for gene therapy in 2018 alone. With this in mind, we expect this market to grow significantly, with ten to 20 cell and gene therapy approvals per year over the next five years. This growth is set to come from a wide range of modalities, from ASOs and RNAi5 —Spinraza and Onpattro being the first two therapies approved using this modality to potentially curative modalities deploying AAV6 and lentivirus therapies, such as Luxturna and Zynteglo. CRISPR (clustered regularly interspaced short palindromic repeats) gene editing–based therapeutics present a long-term growth opportunity, generating significant excitement and investment in the technology (more than $600 million invested in CRISPR start-ups by 2017 and the first in human trials expected to kick off in 2019), however they are unlikely to have significant clinical impact before 2025.
AAV vectors
As of 2019, much of the focus in development has been on monogenic rare diseases; all currently approved therapeutics fall into this category. Rare diseases tend to have clear genomic targets as well as high unmet need in small patient populations. These patients have generally been underserved by other, more traditional, therapeutic modalities (including monoclonal antibodies)—making them ideal targets for gene therapies.
Furthermore, this focus on high unmet need in smaller, underserved populations has enabled faster approval by regulatory authorities than diseases that impact larger patient populations. Most gene therapies have come to market under an accelerated regulatory review pathway (for example, a regenerative medicine advanced therapy or breakthrough designation by the FDA), which expedites the approval process. The importance of this accelerated process was emphasized in a May 2018 speech by then–FDA Commissioner Scott Gottlieb: "These products are initially being aimed at devastating diseases, many of which are fatal and lack available therapy. In these settings, we've traditionally been willing to accept more uncertainty to facilitate timely access to promising therapies."
These accelerated pathways are shifting the paradigm of clinical trials by consolidating the Phase I, II, III process into Phase I, Phase II/III, and confirmatory Phase III trials after approval (similar to the trend in oncology research). The small patient populations also make it possible for companies to experiment with innovative trials designs (with regulatory involvement and approval), including single-arm and novel or surrogate endpoints. However, these trials may also require a different approach to decision-making within biopharma operations.
Although rare disease remains a focus in gene therapy, much of the early-stage gene therapy pipeline is in oncology. As of September 2019, roughly 25 percent of the overall gene therapy Phase I and II pipeline is oncology focused, including 17 Phase I RNA based and 8 Phase I DNA-based therapies. These oncology-directed therapies will compete with more traditional modalities (many of which will soon have biosimilar competition), and thus will need to demonstrate increased cost-effectiveness.
Much of the innovation and development in gene therapy have been driven by smaller biotech companies or research universities, sometimes in partnership with a large pharma company or an entity specialized in the targeted therapy. In fact, 90 percent of gene therapy development to date is from companies with fewer than 500 employees. Many of these biotechs are platform companies who have optimized the manufacturing and delivery of their technology. When combined with the current funding climate, this has enabled many of them to quickly scale to multiple clinical programs across multiple therapeutic areas. As the technology underlying gene therapy matures, large pharma companies are becoming more excited about owning the technology versus partnering, as shown by the recent large acquisitions of Avexis by Novartis (for $8.7 billion) and Spark by Roche (currently in negotiation for $4.3 billion).
AAV Based Drugs
Glybera - Alipogene tiparvovec
Glybera (Alipogene tiparvovec) is a gene therapy treatment designed to reverse lipoprotein lipase deficiency (LPLD), a rare inherited disorder which can cause severe pancreatitis. Glybera is composed of an AAV1 viral vector with an intact copy of the human lipoprotein lipase (LPL) gene for delivery to muscle cells. Data from the clinical trials indicates that fat concentrations in blood were reduced between 3 and 12 weeks after injection, in nearly all patients. In July 2012, the European Medicines Agency (EMA) recommended it for approval (the first recommendation for a gene therapy treatment in either Europe or the United States), and the recommendation was endorsed by the European Commission in November 2012. Glybera was developed over a period of decades by researchers at the University of British Columbia and later Amsterdam Molecular Therapeutics (AMT), which acquired rights to with the aim of releasing the drug in Europe. After spending millions of euros on Glybera's approval, AMT went bankrupt and its assets were acquired by uniQure.
The vector genome contains the transgene expression cassette containing the cytomegalovirus (CMV) immediate early promoter, the cDNA sequence of human lipoprotein lipase variant S447X (LPLS447X), the bovine growth hormone polyadenylation site, and a woodchuck hepatitis virus post transcriptional regulatory element (WPRE) which is required to improve LPL gene expression. The applicant is using the WPRE of WHV in the vector genome without destroying the X-open reading frame present in this region. The expression cassette is flanked by two inverted terminal repeats (ITRs) derived from AAV2. The total length of the vector genome is 3.6 kb. The vector genome, either – or + strand, is pseudotyped with AAV serotype 1 capsids which are composed of 60 subunits formed by three viral proteins, VP1, VP2, and VP3, in a relative stoichiometry of 1:1:10. The major capsid protein is VP3, estimated to represent about 80% of the total mass.
Glybera was the first gene therpay to be approved in Europe. However, Glybera gained infamy as the "million-dollar drug," causing its manufacturer, uniQure, to remove the drug after two years on the European market. As of 2018, only 31 people worldwide have ever been administered Glybera, and uniQure has no plans to sell the drug in the US or Canada.
Luxturna-Voretigene neparvovec
Voretigene neparvovec (Luxturna) is a novel gene therapy for the treatment of Leber's congenital amaurosis. It was developed by Spark Therapeutics and Children's Hospital of Philadelphia. Luxturna uses the AAV2 to carry a functional copy of the RPE65 gene into the retinal pigment epithelial (RPE) cells to compensate for the RPE65 mutation. It is the first in vivo gene therapy approved by the FDA. Leber's congenital amaurosis, or biallelic RPE65-mediated inherited retinal disease, is an inherited disorder causing progressive blindness. Voretigene is the first treatment available for this condition. The gene therapy is not a cure for the condition, but substantially improves vision in those treated. It is given as an subretinal injection.
The voretigene neparvovec genome contains the following components:
1) the cytomegalovirus (CMV) enhancer;
2) the chicken beta actin (CβA) promoter;
3) the CβA exon 1 and intron;
4) the cloned cDNA coding for human retinal pigment epithelium 65kDa protein (hRPE65)
5) the bovine growth hormone polyadenylation (PolyA) region,
6] Two AAV2 ITRs.
7] Small intervening non-functional DNA sequences derived in the process of assembling the genetic elements through recombinant DNA techniques are also present.
Zolgensma-Onasemnogene abeparvovec
Onasemnogene abeparvovec, sold under the trade name Zolgensma, is a gene therapy medication used to treat spinal muscular atrophy (SMA). It is used with corticosteroids as a one-time injection into a vein. It was approved in the United States in 2019 for children less than two years old. Common side effects include vomiting and increased liver enzymes. Serious side effects may include liver problems, low platelets, and heart damage. Onasemnogene abeparvovec works by providing a new copy of the gene that makes the human SMN protein.
Onasemnogene abeparvovec was developed by AveXis, which was acquired by Novartis, based on the work of Martine Barkats from the Institut de Myologie in France. It carries a list price of US$2.125 million per treatment, making it the most expensive medication in the world as of 2019.
The voretigene neparvovec genome contains the following components:
Hemophila Gene Therapy
Hemophilia A is a rare blood disorder caused by mutations in the F8 gene that provides instructions for making factor VIII, a protein that plays a crucial role in forming blood clots. It is the most common type of hemophilia and occurs much more frequently in males; incidence is estimated at 1 in 4,000-5,000 male births. The mutation causes factor VIII to be reduced in amount, absent, or dysfunctional. Because factor VIII is necessary for normal blood clotting, hemophilia A patients have delayed clotting and require regular infusions of either plasma-derived or recombinant factor VIII to prevent life-threatening bleeding episodes.
Haemophilia B is a blood clotting disorder causing easy bruising and bleeding due to an inherited mutation of the gene for factor IX, and resulting in a deficiency of factor IX. Hemophilia B is four times less common than hemophilia A.
At present, BioMarin Pharmaceuticals, Spark Therapeutics, Pfizer, and UniQure all have gene therapy products being evaluated in phase III studies. The BioMarin and Spark products are FVIII gene transfer products and the Pfizer and UniQure products target FIX (see TABLE). Each of these companies have reported factor activity levels returning to the normal range in patients with mild hemophilia in phase I and II trials, although not all these data have been published in peer-reviewed journals
Valrox (valoctocogene roxaparvovec), also known as BMN 270, is an investigational gene therapy being developed by BioMarin Pharmaceuticals for treating hemophilia A with a single-dose intravenous injection. Valrox contains a harmless virus called AAV5 that carries a healthy copy of the factor VIII gene under the control of a liver-specific promoter. Promoters are regions in the DNA that dictate where a certain gene will be active. When Valrox is infused into hemophilia A patients, the recombinant factor VIII gene is delivered into the nuclei of the cells of several tissues, including the liver. However, factor VIII protein is made only in the liver cells because of the liver-specific promoter. It then is secreted into the bloodstream.
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Why Callan
As one of the largest independently owned investment consulting firms in the U.S., Callan is focused on business objectives that solely benefit our clients. This means you get access to a more stable consulting team supported by tools, data, and resources that could only be built by an organization with an exclusive focus on your needs.
Learn about our founder Ed Callan (pictured left)
The best attributes
of a large and small firm
In addition to robust resources that allow us to serve as an extension of your staff, you will receive tailored recommendations unconstrained by "buy lists" or embedded biases. You can count on accurate, timely, and custom reports generated from our proprietary data and performance measurement systems. And you will receive relevant research, education, and dialogue from our experts, delivered to you through the Callan Institute.
Employee shareholders
Our independent ownership has bridged generations and continues to be our reason for success.
Years of industry research
We founded the Callan Institute in 1980 with a mission to improve the investing ecosystem through research, education, and dialogue.
Strategies in proprietary database
That's comparable to leading database providers, couple with 45+ years of consulting expertise.
Our mission and values
Our mission is to advance each client's investment goals. To achieve our mission, we will apply our resources and experience to develop and implement custom solutions on behalf of our clients.
In partnering with our clients, we follow five core values:
- Keep client interests paramount
- Support the success of each associate
- Commit to quality and collaboration
- Work with integrity and inclusiveness
- Honor every commitment
These have been Callan's values since the firm's founding five decades ago and have guided everything we do for our clients.
Client collaboration
We exist because of you. Listening to your insights and closely collaborating with you make us more knowledgeable and more in tune to the needs of the beneficiaries we collectively serve.
Callan turns 50
Callan turned 50 in 2023, and we know who to thank for that. Our clients.
Diverse perspectives
We value diversity of opinion. Because we all have different backgrounds and experiences, we are open to new ideas and perspectives that help find solutions for your unique situation.

subset: commoncrawl


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Spring Cookies
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Nobody has the time to bake up an impressive array of treats like this!These colorful, extra-fancy cookies are sure to impress. With so many varieties of buttery rich cookies, this assortment will be a huge hit with the whole family at Easter. Perfect for:
- Entertaining
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- A gift for those who cherish old-fashioned quality
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Boeken in 2006: 26-31 | home | Boeken in 2006: 39-45
5 april 2006
Boeken in 2006: 32-38
boek 32: Bruiden van God, Heleen Vreeswijk
Vreselijk maar spannend jeugdboek over Kim, die met haar depressieve moeder in een sekte terecht komt. De profeet, die de sekte leidt, hersenspoelt en manipuleert, waardoor niemand wil geloven dat er vreselijke dingen gebeuren in het klooster. En hoe meer Kim tegenstribbelt, hoe meer hij haar wil hebben; zij is immers uitverkoren tot Bruid van God. Het ergste vind ik dat dit boek op waarheid gebaseerd is; in 1997 is er in de omgeving van Arnhem daadwerkelijk een dergelijke sekte "opgerold"..
Conclusie: Aan te raden voor volwassenen, maar of het ook geschikt is voor de twaalfjarigen waar het voor uitgegeven is?
boek 33: Stargirl, Jerry Spinelli
A story about a girl who dares to be different, told by her friend who himself doesn't have the guts to go for it. It shows the lifes of a lot of ordinary and one special teenager and the complications being different in teenager-world will get you in.
Conclusion: Sweet and funny, but also painfully close to the truth.
boek 34: Chameleon, Ken McClure
Women are dying in Kerr Memorial Hospital. They are dying from post operative wound infections which are resistant to antibiotics, and the authorities cannot find the source. At the same time, a psychopathic killer is running amok, committing brutal murders in the town.
The Home Office send an outsider, surgeon Scott Jamieson, to investigate. Jamieson soon finds himself in a maelstrom of accusation and counter accusation. Is this outbreak the result of deliberate contamination, or just a freak strain of bacteria? He begins to suspect that the truth might be far more horrific than anyone could have imagined…
Conclusion: I love medical thrillers, and I loved this one as well, but you need an interest in the behaviour of bacteria to really understand this book.
boek 35: Around the world in 80 dates, Jennifer Cox
This book is part travel guide, part relationship primer, as it mixes wry dating realities with preposterously romantic settings and a slightly more than backpacker budget. Author Jennifer Cox, an experienced travel journalist, gets friends around the world to act as matchmaker for an 80-date spree, and the result is entertaining. Yes, she does find him. And yes, they are currently still together, according to the same source that has information about the upcoming movie based on this book.
Conclusion: Funny, breezy read, an ideal holiday book.
boek 36: The Knowledge: The Gobsmacking Galaxy, Kjartan Poskitt
I've read this "science for kids-book" like a beginners guide to space. It explains "what all the different lumps and bumbs that float around the sky are, it tells you how to get there and what you'll find when you arrive". In a funny way, it tells lots of really satisfying facts, but sometimes you have to look hard for the thruth.
Conclusion: Nice as a "Galaxy for Dummies", but for real science, you'll have to find another book to study after reading this one.
boek 37: The Zahir, Paulo Coelho
I borrowed this book, whose title means "the present" or "unable to go unnoticed" in Arabic, from one of the girls with whom I traveled in Libya. Subtitled A Novel of Obsession, this tale is the philosophical and spiritual chronicle of one man's quest for self-discovery. After the disappearance of his wife, an unnamed best-selling author has to find himself and come to peace with the past, before having a chance to find her again.
Conclusion: This book forces you to think about your own life and your own obsessions. I'd recommend it, but I didn't particularly like the last chapter. This was my first Coelho, but it will not be my last.
boek 38: Someone like you, Roald Dahl
This is a collection of short stories, the Dahl way: with surprises and horror around the corner. In "Taste", the stakes of a dinner-party bet reach distasteful heights; a wife serves up a new dish in "Lamb to the Slaughter"; and layers of deceit are stripped away in "Nunc Dimittis"..
Conclusion: Great read, but not to be read in one go, since you'll start thinking: "Okay, what will be the catch this time?".
Reacties uitgeschakeld voor Boeken in 2006: 32-38


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MINNEAPOLIS — Casey O'Brien, the Minnesota Gophers placeholder who beat cancer four times, posted that he will be undergoing a surgery this week to have a spot removed in one of his lungs.
The redshirt sophomore said on social media that doctors found a small spot on his lungs today while he was in for his three-month scan.
O'Brien, who was diagnosed with osteosarcoma when he was a freshman at Certin-Derham Hall, played in his first game as a Gopher earlier this season, but it's been his journey that's perhaps had the biggest impact.
After making his collegiate debut, O'Brien shared his story as a four-time cancer survivor on the Big Ten Network, and has since become a role model for people across the nation.
O'Brien said on his Twitter page that's he ready to go 1-0 in the surgery season, a reference to the Gophers' mantra this year of week-to-week seasons, and ended it with the hashtag #5x.
An outpouring of support has flooded his comments as people from all over the nation, including from Hall-of-Fame sports broadcaster Dick Vitale.


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Kia Reinvents The Owner's Manual….With Google's HelpAuto News
Kia thinks it's about time the owner's manual got a 21st century upgrade. Calls up Google for a collab.
The owner's manual, when you think about it, is in a very tough spot. To automakers, it's probably a pain and quite a large expense to put it together and print so many copies for so many models and variants, only for it to be opened and actually read by the owner so rarely, if ever.
To owners, most of us find its size annoying, always taking up room in the glove compartment or door pockets, always tossing it to one side when it gets in the way.
In our defence, it's probably easier, more helpful, and much more quicker to punch whatever question we might have about our car (even a super obvious one) into our favourite internet search engine than to leaf through a thick tome of finely printed instructions.
That's why Kia has started to explore other ways to provide owners with access to the information they seek without the antiquity of a printed owner's manual, even partnering up with tech giant Google (and Megazone) to realise it.
The 'Kia Owner's Manual App' operates via your smartphone, as the name already implies. Once installed, it will leverage your smartphone's rear camera to overlay an augmented reality (AR) interface when you point it at a specific spot in your car, displaying all the related information on-screen.
This is where the Google partnership is critical, as the app itself is built on the backbone of the Google Cloud AI platform, which uses machine learning to identify symbols and context within the image. If it matches up with the existing data on its master database, it pulls it down to be shown to the user (owner).
Kia has so far intended it to offer quick, easy to understand explanations and quick instructions on certain car functions. As they put it, "if a user scans the 'cruise control' symbol on the steering wheel with a smartphone, the AI platform will recognize the image via server communication. The smartphone then instantly displays a video introducing the detailed functions of the cruise control system."
In addition, the app is also fully searchable for even more convenience, allowing more seasoned owners to quickly access every bit of information available in the manual based on the keyword or phrase they've entered. However, we suspect only basic features and symbols will be backed up by actual video instructions or explanations, with the app falling back on pure text content when asked about more complex parts of the vehicle.
Kia has been providing augmented reality experiences via mobile apps in certain markets since 2017, but this is promising to be their most comprehensive and far-reaching use of this technology to date. The South Korean automaker has not confirmed a launch date as of yet but is aiming for the second half of 2020 starting with their newest worldwide models.
"The Kia Owner's Manual App will offer a unique customer experience with our products," said Eui-sung Kim, Vice President and Head of Global Dealer & Service of Kia Motors. "Kia drivers will be able to enhance the safety and convenience of ownership with the app, which provides easy and intuitive information on the various functions of their vehicle and our latest technologies."
"We are pleased to collaborate with Kia on this innovative application of AI Platform which is already used in the manufacturing industry to help automate the visual quality control process. The new AI-powered Digital Owner's Manual is a great example of the kind of challenges AI can solve and how it can help enhance the customer experience," said Kiyoung Choi, Country Director of Google Cloud Korea.


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I am an Associate Professor in Human Computer Interaction with the School of Computer Science at University College Dublin and a founding member of the HCI@UCD group. HCI@UCD is an interdisciplinary research group bringing together designers, computer scientists, social and cognitive scientists. We have core research interests in areas including digital health technology, conversational user interfaces, user autonomy, and ethical aspects of design for HCI. We publish regularly in leading journals and conferences, including ACM CHI, and seek to develop technologies that have positive impact on society.
My current research is focused in two main areas:
- Digital Health Technologies: I am a founding member of the Digital Mental Health research lab in UCD and have active projects investigating online help-seeking, games and mobile devices, and blended CBT to prevent and treat mental health difficulties. From 2016 to 2021 I was the Project Coordinator of the EU funded TEAM ITN, a PhD training network in digital mental health. Outside of the mental health space, I have active projects designing technology to support rehabilitation for cancer and cardiovascular disease.
- User Agency and Autonomy: I have a long standing interest in applying implicit metrics – derived from recent research in Cognitive and Clinical Neuroscience – to explore peoples' experience of agency when interacting with new technologies, including intelligent, on-body and sensing interfaces. More recently this focus has broadened to address questions of user autonomy in diverse contexts.
My research page provides further details of current and past research projects.
Prospective PhD Students:
If you are interested in pursuing a PhD at University College Dublin in an area related to my research interests please contact me to discuss projects and funding possibilities.
Current PhD and Post-doc Vacancies:
I am currently recruiting for two positions, a post-doctoral research fellowship and a PhD position in digital mental health. For details and to apply please see the vacancies page.
Sample projects: (Full list here)
|Online help-seeking for Mental Health
Seeking help is an important step in addressing mental health difficulties. This project is exploring theoretical foundations and provides guidelines for the design on online help-seeking technologies. Evidence suggests that positive help-seeking experiences contribute to an increased likelihood of future help-seeking and improved mental health outcomes.
TEAM was a 4 year Innovation Training Network (ITN), funded by EU Horizon 2020 Marie Skłodowska-Curie actions. It provided PhD training in Digital Mental Health. I coordinated the overall network, which focused on developing new technologies to support the assessment, prevention and treatment of mental health difficulties in young people.
|User Autonomy and the Sense of Agency
This project applies implicit metrics – derived from recent research in Cognitive Neuroscience – to explore people's experience of agency when interacting with new technologies, such as on-body and intelligent interfaces.
Leadership Roles: (Full list here)
During my time as an Associate Professor and Senior Lecturer at University College Dublin and and the University of Bristol respectively, I have won in excess of €5million in Principal Investigator funding. I have also led Research Strands in several large-scale research projects. Examples include:
- Project Coordinator & Principal Investigator: TEAM ITN, EU H2020 Marie Skłodowska-Curie Actions (2016-21)
- Funded Investigator: Insight Centre for Data Analytics, Science Foundation Ireland (2014-24).
- Theme Leader: SPHERE Sensor Platform for Healthcare in Residential Environment. EPSRC (2013-17).
- Principle investigator: Integrated support for adolescent mental health, NHS Health Ent. East (2014-15).
- Theme leader: Integrative Epidemiology Unit. MRC (2013-17).
- Principal-investigator: UK Hydrographic Office Knowledge Transfer Partnership (2013-15).
- Principle investigator: Games supporting adolescent mental health, NHS Health Enterprise East (2013-14).
- Personal Fellowship: Marie Curie Post-doctoral Fellowship. EU FP7 (2009-12).


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Our Story
From childhood dreams to sustainable futures
Kennedy Chinyere, director of Trees of Hope, was born and raised in rural Zimbabwe
and has witnessed the effect of over zealous deforestation
for farming, firewood, mining, timber and firing kilns.
At twelve years old Kennedy planted his first trees on the family land.
30 years later and those trees are the inspiration for the Trees of Hope project.
Trees of Hope was constituted in 2020 with a broadly representative committee to oversee work in the UK and Zimbabwe.
Our vision is for a thriving, diverse and balanced ecosystem
and for a return to living in partnership with the land.
Project Aims
Raise awareness of how essential trees are to our safe future in a thriving ecosystem
Design and implement practical sustainable solutions
for tree planting, care & safeguarding
Empower local communities (children, young people and adults)
to create positive change for future generations
Promote the essential relationship between music, landscape and community
Phase One
Completed 2019, working with local communities in rural Zimbabwe using locally sourced materials and labour
Build a tree nursery
Set up a seed storage system
Dig a well to irrigate the nursery
Research trees and map out a forest garden
Consolidate local project leaders in Zimbabwe
Gather footage, photos and interviews for promotional material
Initiate plans for interim activities (May to October 2019)
* Compost making
* Seed collecting & planting


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Senator Christopher Lawrence "Bong" Go on Tuesday urged the Inter-Agency Task Force for the Management of Emerging Infectious Diseases (IATF-EID) to consult more subject-matter experts from various fields and involve groups that are willing to share their expertise.
He said a whole-of-nation approach is needed to overcome the prevailing coronavirus disease 2019 (Covid-19) health crisis.
"Bukas po tayo sa mga suggestions mula sa mga doktor, ekonomista, at iba pa dahil marami naman pong gustong tumulong. Pakinggan po natin ang mga hinaing ng iba't ibang grupo tulad nitong mga nasa medical community (We are open to suggestions from doctors, economists and others who want to help. Listen to the voice of different groups like in the medical community)," he said.
As an elected representative of the people, Go said he will continue to engage with various sectors and assure them that their voices will be heard by the government.
Regarding the suggestions of some groups to reimpose most stringent enhanced community quarantine (ECQ), Go said officials must balance various national interests and consider the capability of the government to provide assistance to the poorest of the poor and other vulnerable sectors.
"Wala naman pong may gusto na bumalik tayo ulit sa ECQ pero kung hindi po tayo magtutulungan, mapipilitan po na higpitan muli ang mga patakaran para mapigilan ang lalong pagkalat ng sakit. Ikonsidera rin natin kung kaya pa ng ating pondo at kung may maibibigay pa ba tayong ayuda kung sakaling kailanganin nating patigilin muli sa trabaho ang mga tao at magsara nanaman ang mga Negosyo (Nobody wants to go back to ECQ but if you will not cooperate, we will be forced to reimpose most strict quarantine to stop the spread of the virus. We will consider the availability of funds for cash aid if we there will be work stoppage)," Go said.
On Sunday, President Rodrigo Duterte approved the recommendations to revert Metro Manila, Cavite, Bulacan, Laguna, and Rizal to more stringent modified ECQ in response to medical community's call for "breather" and to intensify government response against the coronavirus. (PNA)


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Difficult Selections For A Clothing Organization Using Multilevel Advertising and marketing
20 Jul 2018 22:39
You can hold webinars and live events for item launches, hold tutorials, and answer queries in real time. This provides a tangible feeling to your audience and helps them connect more closely with your brand and item. At the finish of the day, keep in mind that amongst other aspects, your on the internet presence is like a residence constructed on the foundation that is content advertising and marketing. If your foundation is weak, it is going to flop.His purpose is to work directly with retailers and have merchandise open on StockX in an initial public offering of sorts. He said that this would supply far more pricing stability, and that allowing average buyers access when new merchandise have been released could support brands expand their customer bases.She produced at least ten bogus profiles for bloggers that were paid for advertising clients' items. Newland pocketed at least £9,000. It really is the new influencer - Current research show that social media is becoming a great sales channel and a lot more and more companies are stating that they get customers from Facebook or Twitter.Your brand must - most importantly - engage and connect with your audience. The above digital marketing methods let you to build on that, escalating your business's visibility and reach in addition to establishing an ongoing connection with your consumers.Set up accounts on Facebook, Myspace and Twitter. look these up need to be independent listings exclusively for your organization, not based on your personal account. Be sure to list your full address. Preserve your pages up to date by listing news, new products and services, sales and other events in a conversational way. 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When a cursor is placed more than the ad, it extends downward to expose an region that, depending on what button is clicked, displays true-time Facebook wall posts, Twitter customers posting about Mrs. Meyers, or a video from the brand about Thelma Meyer, for whom the brand is named.Analytics computer software exists to tell you how customers find your web site and what they do as soon as they get there. If you have any kind of concerns relating to where and how to utilize look These up, you could call us at our own web site. By combing through the data, you http://carlos31a9251241.soup.io/post/660609992/5-Ways-To-Add-Money-To-PayPal can figure out which content material resonates most with your customers. Focusing on what really operates can save time - but it signifies making sure that marketing and advertising pros get weekly analytics updates and reports that support them turn insights into action.Right here at Marketing and advertising Minefield we've covered every single type of marketing and advertising that you can ever wish to use. If you're an on-line business owner head on over to our internet advertising and marketing section, where you will learn every thing from ranking greater in search engines, to constructing an e-mail list.Study after study has established that referral marketing is 1 of the ideal forms of marketing when it comes to sales and conversions. You want to get your affiliate hyperlink and begin advertising. You can use any social media. Employing any email tool is a choice, but men and women tend to check social media updates rather than their e-mail look these up days. Rather, specialize in one aspect of digital advertising and marketing initial. 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Properly, you need to have to concentrate on acquiring the emails very first and foremost. The best strategy is to be transparent and honest with the customer. Tell them what they will get by signing up, and make it appear worthwhile. Gone are the days of emails filled with blatant marketing and advertising and marketing jargon. Now, individuals want to open issues that offer them with one thing beneficial - like guidelines and tips. Combine e-mail marketing with your content approach to send out mini blog ceciliasouza41931.wikidot.com posts and hyperlink back to your website. Give them email content that talks about anything but is also relevant to a item or service, convincing them that it can help them out. As a outcome, you will commence creating a lot more leads and make a lot more sales.
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Medical cannabis (MC) is becoming increasingly popular for the treatment of chronic pain conditions. In this study, we evaluated the effect of MC treatment on pain level and quality of sleep of patients with different medical conditions at the rheumatology clinic.
The post The Effect of Medical Cannabis on Pain Level and Quality of Sleep among Rheumatology Clinic Outpatients appeared first on Society of Cannabis Clinicians.


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To inspire energetic participation on the planet outside by award-winning coverage of the sports activities, folks, places, adventure, discoveries, well being and fitness, gear and apparel, trends and events that make up an lively life-style. Get your profession in health and fitness transferring with the ACE Group Fitness Teacher Profession Guide. Their study members, aged forty-70 years old, didn't have cancer when they underwent fitness assessments. Research revealed in 2010 within the American Journal of Medical Vitamin reveals that individuals with elevated intakes of refined grains are significantly extra prone to have excess belly fats than those that favor more fiber-rich grain-based products.
Nevertheless there may be historic, cultural or anecdotal evidence linking their use to the treatment of Weight Loss. It's good for people who want so as to add more protein to their diets however preserve calories low. If somebody needs to shed pounds, they need to pay attention to the whole lot that they eat and drink every day. Eating six small meals per day is the primary Healthy Habit you'll study.
Although not a brand new idea, gyms have similarly partnered with brands like Kettlebell Kitchen and Territory Foods to convey healthy, pre-portioned meals for fitness-centered consumers. It was once thought that the important thing to weight loss was eliminating all excessive-carbohydrate foods, including pasta, rice and potatoes. Foods within the milk, yoghurt, cheese & alternate options group primarily present us with calcium and protein, plus different nutritional vitamins and minerals.
Common journeys to the fitness center are great, but don't worry if you cannot discover a big chunk of time to train each day. 1 Even for folks at a healthy weight, a poor weight-reduction plan is associated with main health risks that may cause illness and even death. Meat could be a nutritious and healthy part of your eating regimen. Healthy or good†fat can actually assist to manage your weight, in addition to manage your moods and fight fatigue.
Eating a healthy breakfast is very important on days when train is on your agenda. Your physique slows its metabolism , making it very difficult to take care of any weight loss. Make Your Energy Depend: Use the Vitamin Facts Label for Healthy Weight Administration from the FDA's Heart for Food Safety and Utilized Vitamin is an interactive learning program that provides customers with information to assist plan a healthful diet while managing calorie intake.


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Whether it is during your morning routine, while you are out to lunch, or at the gym, Out of Home (OOH) advertising is becoming more than your traditional "billboard ad" by reaching large audiences in not-so-traditional ways. A study by the Outdoor Media Association found that out of home advertising makes up 20% of people's daily media consumption, and that people are twice as likely to act on messages they receive out of their home. So what are the types of out-of-home advertising, and how can you use them to get the best results?
Basic billboards are still a major aspect of OOH, but the digital era has inspired advertisers to integrate digital signs as well as interactive displays in malls, airports, grocery stores, and on public transportation. Advertising is getting better at reaching consumers wherever they go, whether on supermarket shopping carts, in sports arenas, or in health clubs.
OOH ads can be delivered via:
Billboard advertising is one of the most traditional forms of advertising. Billboards are strategically placed in high-populated areas including key highways and intersections. These large formatted advertisements offer tremendous visibility to vehicles, reaching both the driver and the passengers and offer businesses an enormous creative canvas to display their advertisement. As OOH media grows, billboard advertising remains relevant and effective when reaching customers. The quick and clear messages that billboards send continues to catch the eye of diverse groups of people.
Bus advertising provides businesses a prime audience of potential customers. Having a moving billboard offering superior eye level coverage, an advertisement placed on a bus reaches commuters, workers, and areas where traditional outdoor media is limited or unavailable. Bus advertisements are great for reaching pedestrian and vehicular traffic and continue to be a popular choice for media placement, because like billboard advertising, it offer businesses a way to reach travelers and commuters no matter where they're going or what they are listening to.
Cinema advertising is another of the more traditional out of home media options. It is a dynamic advertising medium reaching consumers who are uniquely attentive. Theaters may be one of the few places where people know it is taboo to look at their mobile devices, a challenge that regular TV faces frequently. So cinema advertising gives businesses a chance to show their messages to an engaged audience, on an enormous screen with outstanding quality sound. This is where cinema advertising comes in handy for businesses, having the opportunity to capture people without a distraction.
In the past, a billboard or outdoor ad was a simple way to generate brand awareness. The trouble is, it can be rather difficult to express a strong message on a medium that people see for only a few seconds. So, it is important to have the support of TV, direct mail, radio, and print advertising and to layer both digital and static OOH into an integrated campaign. In short, keep the product or service prevalent, but let the other forms of advertising aid the storytelling so the important messages don't get lost.
Increasingly, with the rapid growth of mobile technology, outdoor advertising can do more to drive people to take a direct action than in years past. With OOH as part of a campaign, it gives marketers yet another funnel entry point to use to attracts consumers. According to Outfront Media, adding OOH to your media plan allows businesses to connect with their customers, increase engagement, drive sales, and increase brand awareness. Outfront Media explains how adding OOH to your media plan can increase campaigns drastically:
Some outdoor advertising can become the focal point for an entire campaign, especially if it drives interaction with users and their cell phones. Recent examples include the TNT "Push To Add Drama" stunt, showing consumers that TNT's goal is to capture attention and give their viewers the shows and drama they want with a push of a button.


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Why is America the greatest nation in history? No other country provides a daily challenge and the need for utilizing every physical, mental and creative ability in each of its citizens. All of these abilities are called upon in the operation of opening American Packaging. The necessary medication prescribed by one's physician, lies tantalizingly out of reach, visible but not reachable. Her dinner salad waits in it's plastic coffin, to be seen but not taken. The mausoleum of his iPad resists easy entry. Many an ailing person has seen his medication crushed to powder, only to lie scattered on the floor after futile attempts with nail scissors.
However, using the correct tools and applying patience and skill these challenges may be over come. First, gather the tools. Opening any of these packaging's cannot be done on a regular counter top for fear of damaging it. The procurement of a small anvil will suffice, do not jab at the imprisoned pill in its blister back with a fingernail. Have the following items handy; one EMY scissors (ordinarily used to cut seat belts,) one needle-nose pliers, one ridged ladies hack saw, (with small medium and large toothed blades), two screwdrivers for prying off the outer lids of push and turn caps. After the hacksaw has been used, the inner cap is a screw top, save these for future bottles of the same size. A small ladies acetylene torch, one found in every well ordered home, is essential and far superior to razor blades, especially if the user has an unsteady hand. In fifteen or twenty minutes one can open even the heavy plastic that things like cell phones and iPads are enclosed in.
However, if one is wealthy enough, and wishes to negate the democratizing tendency that packaging presents, another option is available. And that is, to hire a criminal. Here too, America leads in the number and availability of its criminals. Go on-line and access Santa Clause to find if the prospect is naughty or nice. Hire a nice one. Most criminals are out of work unless they are robbing banks, and should be free to help you. Access them in the following exchange, "Mike and I have a headache rush up here and open my bottle of aspirin." He might answer, "Call Ken I am busy here at the old age home." Make sure the criminal you hire has the tools necessary, most of them do. A well-compensated criminal should be serviceable for many years.


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Out of all of the breakdowns I've done thus far, this one promises to feature the highest grade average. The Falcons are quite simply stacked like Tetris at linebacker, which bodes well for our defense in general next year.
Join me as we roll with K-Brook, M-Bol, Stevie Nickels and the rest of the crew, after the jump.
OLB Michael Boley: Whatever his faults are off the field, Boley only has one setting on the field: Destroy. He pursues quarterbacks like they just stole his watch and charges at offensive linemen with such velocity that they are reduced to loose clouds of particles. When someone once said "something wicked this way comes," they were talking about Michael Boley. And so on.
While you can argue that Boley isn't the best linebacker in the league, he's certainly one of the most complete. There are very few holes in his game, whether you look at his ability to cover a tight end or simply force a quarterback to contemplate his impending doom. If he stays healthy, he's a near lock to amass 80 tackles, 5 to 10 sacks, a couple interceptions and a few forced fumbles. He'll do all of this while constantly trying to improve, as he has done each year he's been in the league thus far.
Still underrated, Boley isn't just the Falcons' best linebacker. He's also their best player, and legal troubles aside, that doesn't seem likely to change. Get ready for another year of the Michael Boley Crush N' Annihilate Show, folks.
Final Grade: A+
via espndeportes-akamai.espn.go.com
MLB/OLB Keith Brooking: Brooking is an interesting case. He will always be remembered as one of the classiest Falcons ever to take the field, and he's also been one of their best players for a very long time. I'm sometimes a little baffled at how hard fans come down on Brooking (including, often, myself) because he's declining. What exactly did we expect?
Brooking is better suited to the outside at this stage in his career, as running backs who power up the middle have proven to be his Achilles heel. While he was once a less physically dominant version of Boley (i.e. extremely well-rounded), Brooking's skillset has taken a hit in general. Far from being dominant, Brooking now is best considered a serviceable starter on the outside and a mediocre one up the middle. His range just isn't there anymore.
That being said, he's likely to start and should look a little better this season if the team is wise enough to roll him out. If the defense is better up front, that would be an added bonus. Still, as much as I love him, it's hard to grade Brooking that highly.
Final Grade: B-
MLB Curtis Lofton: You'll hear a few grumblings and mumblings about playing Curtis Lofton in the middle over Keith Brooking, but there's no reason to believe that he isn't the real deal. With good lateral range and the ability to punish those heading up the middle of the field, he's got the ability to be at least a solid middle linebacker for the next eight to ten seasons. When Brooking is clearly better outside, why would you start him anywhere else?
Lofton's major advantage over Tony Taylor (who I like a great deal) is that he's a far more physical player. He's not the world's fastest guy, but he's plenty fast to play up the middle. The coaching staff coveted Lofton precisely because he fits into the smart, blue collar vision they're looking to instill into this team. He'll make his mistakes in the early going, but there's nobody I'd rather see here down the line.
No better time to start looking at him than right now, either.
Final Grade: B+
via lh4.ggpht.com
OLB Stephen Nicholas: Nicholas isn't very likely to start this year. Unfortunately, he's last regime's draft pick and last regime's favorite, and it remains to be seen whether or not he'll get a fair shake from the new guys. That's partly based on the fact that Nicholas isn't going to blow anyone away with his play, of course.
Stevie Nickels is fast. He's like Demorrio Williams in that he's speedy and undersized, but he's got the potential to become a much more complete linebacker than D-Mo ever was for the Falcons. He will need to get stronger to impress Mike Smith and crew, because I suspect they view a guy his size as more of an edge rusher (ala Kroy Biermann) than a true starting linebacker. Still, someone's going to have to take over when Keith Brooking goes to that big retirement party in the sky, and Nicholas is probably the best option on the roster.
Even if he never steps up to become a starter again, he's a great fourth linebacker that offers better straight speed than most. A valuable piece, that Stevie Nickels.
Final Grade: C+
via fantasykat.com
MLB Tony Taylor: Taylor has a reputation as a brainy sort of fellow, which is probably why he's managed to stick around. He's listed as 3 inches shorter than Nicholas and three pounds heavier, so he isn't particularly huge. He's also not the world's hardest hitter, a fact that will likely help keep him behind Lofton on the depth chart. It's hard to overtake a guy who has tools in spades when you've got a rather limited set of them.
Still, Taylor would be exactly the kind of guy you'd want to run your defensive plays through. I think he's go an excellent shot of sticking around as a reserve, maybe running a season or two with a starting unit, and ending up as a coach in this league. For now, I'm hoping he'll give Lofton or Brooking a good fight and provide quality depth for the team. He could also be very valuable on special teams. Given that, I think I'll grade him as a backup.
Final Grade: C+/B-
OLB/DE Kroy Biermann: Get it? It's because his name is Biermann, which sounds like Beerman, which like Duffman?
I'm hilarious!
Anyways, Biermann is currently listed at DE and Robert James is listed at OLB, but I think you're more likely to see Biermann at OLB and James at safety. Biermann's primary value is as a guy who can rush off the edge, slip through blockers and stop a play from happening in the backfield. Smith and Comrade Dimitroff seem very fond of the idea of a pass rush specialist, and Biermann's speed and elusiveness makes him perfect for that role. His use is still very limited, though.
Final Grade: C-
Analysis: With this crop, you've got your starting-caliber linebackers, you've got your solid backups and even a specialist or two. There's nobody in this group that I believe will be truly weak, and guys like Tony Taylor or Stevie Nickels have a good shot at contributing above and beyond our expectations.
So even if this season turns out to be a dark menace looming in our memories for years to come, we ought to be able to enjoy the play of our linebackers. If nothing else, that's something to look forward to.


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Lunch at David's Hutte after a 20 minute walk from the village. The classics of ribs, chicken wings and schnapps!
Posted on Saturday, December 24th, 2011 at 6:15 pm. Filed under: Austria, Yummy stuff RSS 2.0 feed.
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We want pool and spa ownership to be fun and easy. The best way to accomplish this is by providing all of our knowledge to you. We have compiled our articles, simple guides, and videos so that you can find a learning method that works best for you. Zagers continually adds new content to this educational area so be sure to check back frequently for updates!


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Northern Tier Bicycle Route #1
Anacortes, Washington - Sandpoint, Idaho (462 miles)
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Because of heavy snow, the North Cascades National Park is only open to through traffic on SR 20 between late April and late November. The Anacortes area is hilly, the roads are curvy, and there is a moderate amount of residential traffic. The 4-lane highway that heads east to the mainland is very busy. After crossing the Skagit River flats, the route starts a long, gradual climb to the Pacific crest of the Cascades. In most places either the roads are wide or the traffic is light.
After Washington Pass, the route climbs and descends a pass almost daily until reaching eastern Washington. Once in Idaho the terrain flattens as you wind your way along the Pend Orielle River into Sandpoint.
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The maps are waterproof and designed to fit in a handlebar-bag window or jersey pocket. The maps provide information specifically for cyclists: the location of bike shops, sources for food and water, and listings of overnight accommodations including camping facilities, small hotels, and cyclists-only lodging.
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What does Judaism say about the afterlife? Exploring the inherent conflicts between the different ideas and why that's a good thing.
Exploring Judaism is a home for the Torah of Conservative Judaism, embracing the beauty and complexity of Judaism, and our personal search for meaning, learning, and connecting. There is always something to learn and explore.


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Then the narrator (the wife says it was Sigourney Weaver) said something like "but there is a new disaster facing the Sahara." And I assumed, correctly, that that disaster would turn out to be "Global Warming".
Sure enough, that's what she said. But the disasterous effect Global Warming would supposedly have on the Sahara, she went on to say was....
are you ready for this?
... that it would turn back in to a lush jungle!!! *GASP*!!!!!!!
That's right, it would supposedly cool and get wetter due to changing circulation patterns, turning the famous barren wasteland into a font of life and diversity. You know, more lungs for the earth. Undiscovered cures for diseases we're always hearing about coming from our (disasterously disappearing) jungles and rainforests. Habitat for jungle creatures. Livable conditions for humans. Gigantic carbon sink. Disaster!
So apparently any change, anywhere -- in the climate has known for the past few hundred years is apparently a defacto disaster, then, to Enviroligionists.
Part of the enviroligion is the idea that "earth is in a delicate balance". But that is a myth. The earth has been changing from the very beginning. Plant life --- trees themselves -- dramatically "changed" the earth, its atmosphere, its climate. Bacteria. Algae. Huge impact on the climate and makeup of the atmosphere. But somehow, humans are separate. We are a cancer. As if we are not just as much from and of this earth as any other life form we see around us.


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text: Statistics Quiz • by Monica Lowe Why do moths fly around lights? Out of curiosity They gather by light to find mates Because the light is brighter in one eye than the other For the warmth the light gives off ? ? ? Sign up for Zadavaka and get these hints!


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Norfolk: Cultural & Financial Hub
Norfolk foreclosed homes and houses for sale currently number 432, and sport the median listed price of a relatively modest $147,210. The nearly 800 other houses scheduled for property auctions in Norfolk have the average price of $235,000. Hence, it can be concluded that the seized homes are being sold at approximately half the rates at which the other FSBO {for sale by owner} homes are being offered to the public for purchase. Michael Zarpas, Joan Buckle, Dottie Garrett and Mike Mc Cabe are influential property brokers in Norfolk who frequently determine the outcomes of the Norfolk real estate listings auctions.
Norfolk is an independent city in the Commonwealth of Virginia in the US. Norfolk is a part of the Virginia Beach-Norfolk-Newport News, VA-NC MSA. Norfolk is regarded as the cultural, historic and financial nerve center of the area. Norfolk Naval Base is the biggest such base in the world. The MSA includes the following counties: York County, Gloucester County, Surry County, Isle of Wight County, Mathews County and James City County. Primary suburbs of Norfolk include the cities of Williamsburg, Chesapeake, Virginia Beach, Hampton, Suffolk, Newport News, Portsmouth and Poquoson.
Foreclosure Auctions: An Irresistible Bargain
The government foreclosures in Norfolk have stirred prospective homebuyers' interest and enthusiasm with the diverse range of gorgeous homes that they offer at practically throwaway prices. Several websites plainly advertise the real estate listings auctions as a chance to get homes a half their usual prices. That the investors are leaping in to benefit from this boom is manifest in their keen participation that the property auctions are evoking. The foreclosure auctions excite and evoke the prospective homebuyers because of several cogent reasons. Firstly, the houses are usually marvelous homes in choice locations. They are well worth an outright purchase. Secondly, the weird circumstances leading to the foreclosure auctions ensure that the homes are listed at inviting markdowns of between 10 percent and 50 percent of their prevailing market prices. Nobody would want to ignore the chance of buying a splendid property at an immensely discounted price. The procedures of the real estate listings auctions are uncomplicated, transparent and fair. Besides, the houses have safe titles and are unencumbered by any lien.
The banks and government agencies like VA and HUD that have foreclosed the houses in Norfolk are keen to get rid of the properties at the earliest. Their basic intention is to quickly recover the outstanding amount on the mortgage loans that they had earlier advanced to the defaulting owners. The actual market evaluations of the seized homes, or the tremendous profit potential innate in their planned sale, neither interest nor concern the auctioneers. This converts into a boon for home-hunters, who receive wonderful homes at enormously concessional prices on a platter. The foreclosure auctions draw umpteen speculative investors also, who wish to pile up good assets at low rates with the intention of flipping them for handsome profits once the tide turns and real estate prices rise in the economy, as they must with time.


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Artificial intelligence powered voice guidance start-up has been chosen to join the British Airways accelerator programme
Copenhagen start-up Whispr secures place in IAG's accelerator Hangar 51
Artificial intelligence powered voice guidance start-up Whispr has been chosen to join Hangar 51, the British Airways accelerator programme.
The Copenhagen-based firm is one of 13 chosen by Hangar 51. Six months ago it raised $750,000 pre-seed investment from Seedcamp and Bose Ventures.
The firm, whose technology helps frontline workers do their jobs more effectively, has also agreed three commercial contracts with Radisson Blu, co-living business lifeX and Duuo a Danish facilities services company whose clients include Topshop.
Whispr said it is now preparing a second fundraise which it hopes to complete at the New Year.
Hugh O'Flanagan, co-founder and chief executive of Whispr, said: "We are thrilled to join this year's Hangar 51 accelerator.
"The recognition from IAG, one of the world's largest airline groups, is further validation of what we have built at Whispr and will add rocket fuel to our platform.
"With airlines increasingly looking at ways to streamline operations and embracing ways to digitise their processes, this is an incredible opportunity for our young business."
Dupsy Abiola, BA parent IAG's head of global innovation, said: "Hangar 51 provides unique advantages to start-ups.
"It aims to rapidly validate their products on real-world business challenges to accelerate their growth.
"This is a great opportunity for start-ups seeking to highlight the potential of emerging technology and new ways of thinking while IAG explores innovative applications to transform customer experience."
For the next ten weeks, Whispr will be embedded in the heart of IAG working alongside mentors and experts from across the airline group.
The programme is designed to help start-ups develop their businesses, test them in live environments on a global scale in the context of aviation, and offers an opportunity to receive investment from IAG's multimillion-pound digital fund.
Based in Madrid for the duration of the accelerator programme Whispr will partner with Iberia, the Spanish airline.
Founded in August 2018, Whispr's voice guidance platform is designed to help frontline workers be eyes-up and hands-free and carry out manual tasks more effectively.
Built on Natural Language Processing and AI, Whispr's application literally whispers instructions and smart checklists into workers' ears as they do their jobs, from carrying out aircraft inspections and repair work to cleaning a hotel room or office.
It ensures processes are adhered to correctly and delivers guidance to workers when they need it.
Through leveraging open application programming interfaces (APIs) Whispr is able to translate processes into the native language of the worker in real time.


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Idris Elba Links With Aero Manyelo & Mahotella Queens In 'Aero Mathata' [Premiere]
Stream our premiere of Idris Elba's "Aero Mathata," featuring beatwork from Aero Manyelo and vocals from Mahotella Queens.
"Aero Mathata" is the lead track from Idris Elba's upcoming mi Mandela album, a Madiba-inspired 11-track ""celebration of South African music" that Elba curated, wrote and produced alongside SA and British collaborators. The single blends harmonies from 60s Mbaqanga 'girl group' Mahotella Queens over an infectious afro-tech concoction from producer Aero Manyelo. Elba's idea for mi Mandela was conceived while he was in Johannesburg filming Mandela: Long Walk To Freedom. Recorded between in Johannesburg, London and Mali, the album will feature an eclectic cast of contributors including Mumford & Sons, James Blake, Cody Chestnutt, Nothembi Mkhwebane, Mr. Hudson, Phuzekhemisi and more. Idris Elba Presents mi Mandela will be released on November 27 on 7wallace (Elba's own imprint)/Parlophone., pre-order it here.


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The SJIII 3219 features durable steel swing-out component trays, providing unrestricted access for easy maintenance and service.
Features Include;
Drivable at full height. Variable speed, front two wheel hydraulic drive. 90‹ steering (zero inside turning radius). Dual holding brakes. Proportional controls for drive & lift functions. 3f (0.91 m) Roll out extension deck. 24V DC power source. Low voltage battery protection. 30% Gradeability. Solid rubber, non-marking tires. Pothole protection system. 110V AC outlet on platform with GFI. 28 mph wind rating (12.5 m/s). Tilt alarm with drive & lift cut-out. All motion audible alarm. Lanyard attachment points. Operator horn. Forklift pockets and tie down/lift lugs. Relay based control system. Color coded and numbered wiring system. Telematics ready.
This download includes the SKYJACK Access Platform - SJ3219 BIM components from SKYJACK.
Keywords: MEWP, Mobile Elevating Work Platform, Access Platform, Work Platform, Aerial Work PlatformRead more


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Green World Express is the first dispensary you see on the right, as you get into Antonito Colorado heading North from New Mexico.
Most people say we are the easiest to spot because of our proximity to the locomotive.
We provide an amazing customer experience ensuring that everyone leaves with a smile and not a huge dent in their wallet. Our sugary potent flower, concentrated extracts and edibles are enough to send even the most experienced smokers into complete relaxation. The finest selection of smoking accessories and free treats - plus soda pop - for our customers.
Some people never want to leave and thats just how we like it. Stop on in for our deals and discounts or just to share an informal conversation with our experienced bud tenders.
Antonito Location
Located along U.S Highway 285, 10 minutes from the Colorado / New Mexico border.


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tag:blogger.com,1999:blog-7291995956909405154.post6381142056735569965..comments2023-09-25T13:42:59.269-05:00Comments on THE FRENCH HUTCH: A VALENTINE'S SERIES, A TINY FRENCH TEA FOR TWOThe French Hutchhttp://firstname.lastname@example.com:blogger.com,1999:blog-7291995956909405154.post-82800339762842772052018-02-08T21:55:38.767-06:002018-02-08T21:55:38.767-06:00What could be better than lunch spent with a good ...What could be better than lunch spent with a good friend? I'll tell you...lunch in France of course! Add in some thumbprint cookies and that makes for a perfect day :).

xxxDoreen@foxdenrdhttps://firstname.lastname@example.com:blogger.com,1999:blog-7291995956909405154.post-11008243325155551562018-02-08T11:08:17.139-06:002018-02-08T11:08:17.139-06:00How sweet Emily! Glad Annabell and Skylar were abl...How sweet Emily! Glad Annabell and Skylar were able to enjoy their French tea at the Paris Cafe. The dolls are so cute and so special as is the Dear Friends box. We are going to Paris and Normandy in the fall so I am particularly interested in all thing French right now. Judy Biggerstaffhttps://email@example.com:blogger.com,1999:blog-7291995956909405154.post-22739633041875565352018-02-08T09:41:01.660-06:002018-02-08T09:41:01.660-06:00Oh Annabell and Skylar are absolutely gorgeous! T...Oh Annabell and Skylar are absolutely gorgeous! Their faces and hair are amazing and then their dresses are revealed - swoon! I am in love with them and of course I am willing to travel to France with them for tea. What a darling tablecloth too! Everything was just delightful. I can see my little granddaughters being enchanted with this.Jacquelinehttps://email@example.com:blogger.com,1999:blog-7291995956909405154.post-50844911728247984472018-02-08T08:19:59.179-06:002018-02-08T08:19:59.179-06:00What a fun tea with Annabelle and Skylar! I loved...What a fun tea with Annabelle and Skylar! I loved playing along with your whimsical tea, Emily. The treats looked perfect and the Quimper teaset is just darling. Thanks for the fun time! xxkitty@ Kitty's Kozy Kitchenhttps://email@example.com:blogger.com,1999:blog-7291995956909405154.post-57526784670218465482018-02-07T13:20:52.663-06:002018-02-07T13:20:52.663-06:00Oh I love the Dear Friends dolls, reminds me of Ni...Oh I love the Dear Friends dolls, reminds me of Nicole Sayre dolls or Bethany Lowe
I have never been to France and enjoy it through others pictures and postsCurtains in My Treehttps://firstname.lastname@example.com:blogger.com,1999:blog-7291995956909405154.post-49787742302902742852018-02-07T10:21:28.999-06:002018-02-07T10:21:28.999-06:00How sweet! The glitter spoons are just adorable! ...How sweet! The glitter spoons are just adorable! I have never been to Paris - maybe someday!Patti @ Pandoras Boxhttps://email@example.com:blogger.com,1999:blog-7291995956909405154.post-12144728533667576842018-02-06T22:13:34.056-06:002018-02-06T22:13:34.056-06:00Emily, Beautiful photos - I feel like a tea party!...Emily, Beautiful photos - I feel like a tea party! The clothe and lace are gorgeous, the dolls very french and love the dishes! Thanks for sharing!
email@example.com:blogger.com,1999:blog-7291995956909405154.post-39439615062492503532018-02-06T15:38:34.829-06:002018-02-06T15:38:34.829-06:00I think Valentine's Day was invented just for ...I think Valentine's Day was invented just for you! All the pretty frills and ruffles and romance, it's got your name all over it. Leslie Anne Tarabellahttps://firstname.lastname@example.com:blogger.com,1999:blog-7291995956909405154.post-56502909202596998312018-02-06T09:36:37.282-06:002018-02-06T09:36:37.282-06:00Tea for TWO sounds perfect to me and those cookies...Tea for TWO sounds perfect to me and those cookies look divine! Lesliehttps://firstname.lastname@example.com:blogger.com,1999:blog-7291995956909405154.post-8900950057041576112018-02-06T08:37:55.650-06:002018-02-06T08:37:55.650-06:00Coucou Emily, quel régal ce billet à l'accent ...Coucou Emily, quel régal ce billet à l'accent de Paris !
J'ai bien sûr un gros coup de coeur pour ce joli service à thé de Quimper, en Bretonne que je suis !
Tes mises en scène sont magnifiques et évoquent pour toi de jolis souvenirs de Paris.Je te félicite.
Bisous,
LylouLylou.annehttps://email@example.com:blogger.com,1999:blog-7291995956909405154.post-39234155549683541722018-02-06T08:00:21.118-06:002018-02-06T08:00:21.118-06:00Oh Emily how much fun you are having!! Those dolls...Oh Emily how much fun you are having!! Those dolls are beautiful, I was shocked to learn they were from PB, I thought they surely were from France! Such an adorable vignette and sweet tale! I agree, there is nothing better than a lunch with a friend in a pretty setting!
Jennathepaintedapron.comhttps://email@example.com:blogger.com,1999:blog-7291995956909405154.post-80713894191984546932018-02-06T07:44:16.557-06:002018-02-06T07:44:16.557-06:00Oh Emily, I feel like I was transported to another...Oh Emily, I feel like I was transported to another world. Your tea set is adorable. I have a teeny tea set done for the Queen Mum's birthday years ago, just about that size and you remind me it's time to get it out! I really like how your journey comes to life as you share your special finds. And the dolls are just adorable! A lovely tea!Jeaniehttps://firstname.lastname@example.com:blogger.com,1999:blog-7291995956909405154.post-35923573803155213022018-02-06T05:36:18.220-06:002018-02-06T05:36:18.220-06:00This is precious! Adorable dolls, setting, furnitu...This is precious! Adorable dolls, setting, furniture, tea set and treats.
How special to reminisce about your trip to Paris with friends.
I so enjoyed the tea party!Bonniehttps://firstname.lastname@example.com:blogger.com,1999:blog-7291995956909405154.post-64635857459600934352018-02-05T19:42:44.223-06:002018-02-05T19:42:44.223-06:00Your little Quimper tea set is so flippin' cut...Your little Quimper tea set is so flippin' cute, Emily! I love all your special touches for Valentine's Day. You are so good at putting adorable little vignettes together!!! Ricki Treleavenhttps://email@example.com:blogger.com,1999:blog-7291995956909405154.post-36590455562549340862018-02-05T19:24:08.824-06:002018-02-05T19:24:08.824-06:00Emily, your little tete a tete over tea between th...Emily, your little tete a tete over tea between these two friends makes me smile for many reasons. It brings back such fond memories of time spent in Nice, France with you and Jim and the other QCI friends, that petite Quimper tea set was the perfect souvenier from that trip. Granted the return to Paris was not without stressful arrangements, but we all made it. Thanks for sharing this delightful little interlude. Every detail is charming.
Today was dreary here as well and cold again after 70s yesterday. Winter is not over just yet.
Annabelle and Skylar are dear. I look forward to this Valentine's series. Sarahhttps://email@example.com:blogger.com,1999:blog-7291995956909405154.post-77663350170835532302018-02-05T15:26:42.228-06:002018-02-05T15:26:42.228-06:00Emily, what a perfectly lovely post. I love your ...Emily, what a perfectly lovely post. I love your Quimper tea set. I love how you tell us where you bought everything. I bet that every time you use that tea pot you have a warm memory of the sale in Nice. Thanks for letting me in on a wonderful afternoon. Now, can I have a couple of those yummy cookies?Preppy Empty Nesterhttps://firstname.lastname@example.com


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When we sit down to eat dinner on Christmas Day our plates are typically piled high- and at Christmas time we don't hold back with the sweet treats after dinner either.
Most of us learn to accept we will pile on the pounds over Christmas which means copious amounts of chocolate and other naughty treats are consumed with little thought for our waistlines.
And it's not just Christmas Day we stuff our faces- it's Boxing Day too!
But, what actually happens to our body after we've demolished a Christmas dinner?
Healthy eating experts over at musclefood revealed to North Wales Live what happens to our bodies after consuming so much stuff on December 25.
This is what they say happens to your body after you clear your plate on Christmas Day:
After an hour
Usually an hour after eating a big meal you're left feeling sluggish, this is because the drinks you enjoyed earlier are now working to slow down digestion.
The rich foods you find on a Christmas dinner can also be difficult for your body to break down.
To help with the breakdown of food there is an increase in blood flow to your digestive tract and your body naturally increases its metabolic and heart rate, resulting in your internal temperature increasing.
Two hours later
By this point you're feeling less sluggish and more bloated and uncomfortable.
This is because the proteins and fats sit in your stomach for two to three hours.
This is also when wind hits, as your stomach squeezes to get rid of all the air you swallowed when eating.
Six- eight hours after dinner
Now you'll find yourself picking at leftovers or rummaging through that box of Quality Street chocolates.
All the food and drink is now in the large intestine – a process that can take six to eight hours.


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Main Services: Plumbing. Kitchen and bathroom remodeling
With over 15 years of experience, Dyson Construction has been providing our customers with the highest quality service. We have built a reputation for quality, reliability and complete customer satisfaction. You can take care of all your residential and commercial plumbing and heating needs from the ground up on any project, big or small.
While our highly trained technicians take care of your job, you can be assured that the price you are quoted at the beginning of the job is the price you will pay. You have our 100% Customer Satisfaction Guarantee! There are no hidden fees, just guaranteed reliable service! Our plumbing residential expertise includes but not limited to: Plumbing renovation and remodeling, Installation of all faucets, fixtures and specialty items, Unclog Drains – Main sewer line and branch lines, Water Heater installation or repair, New Tank less Water Heater Systems, Water line repair and replacement, Sewer line repair and replacement, Kitchen sink installation, Dishwasher installation, Faucet rebuild, and still more! Dyson Construction can meet all your commercial plumbing needs. We can handle any size commercial job from small repairs to new construction and everything in between. Our projects are tailored to clients and we offer competitive bids. A few commercial services we specialize in are:
Garbage Disposal unit repair / installation, Sewage pump repair / installation, Sump pump repair / installation, Whole house re-piping, Water pressure testing and adjusting, Ice maker installation, Gas leak detection and repair, Gas appliance installation, Correct gas pipe sizing, Whole house plumbing inspection, Sprinkler system repair and maintenance, Bathtub removal / installation, Toilet repair / Installation, and more!
CA Plumbing License in CA :


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X-Treme.............16.2h of suberb conformation and unsurpassed beauty all in one package!
Twice "Unanimous World Champion!!!"
"Forever in our hearts/Unanimous World Halter Champion: TF X-Treme"
"Homozygous Pinto!"
Sire: The Color of Fame
Dam: Norsk's Glitter Queen ( double (black) Status Symbol daughter!)
His name says it all. More than you expect in all aspects! Superbly beautiful head with big popping eyes. Outstanding legs and feet. Upright carriage with a big hooky neck and high, high natural tail carriage often missing in the Saddlebred. He has it all along with great totally natural motion!
*Homozygous pinto: All his foals will be pinto!
*Double registered Saddlebred and Pinto.
*Foals from Saddlebred mares can be double registered to show in two breed shows.
*Foals from Arabian mares can be "triple" registered for more opportunities.
*IAHA Sweepstakes Nominated for Arabian mares.
*National Show Horse Nominated Sire.
*Measures over 16.2h.
*Super straight, very correct legs!
*Upright carriage!
*Great presence, yet a fabulous disposition!
*Gorgeous typy ears; short stunningly beautiful head!
*Well set on neck on a body with great substance and perfect topline!
*Short coupled, laid back shoulder, long hip, level topline!
*High NATURAL lofty tail carriage!!!
*X-Treme was awarded the Register of Merit in halter (It takes 36 point to achieve this; X-TREME HAS 116 POINTS)!
*PRODUCING BLACK AND WHITE ON NOW SEVERAL FOALS THROUGH HIS DAM (who is double Status Symbol....Status Symbol was black and the top producer of champions in the Saddlebred breed two years in a row!!!)
STUD FEE: NO LONGER AVAILABLE AT STUD. Some offspring may be available in the future via frozen semen. Frozen straws are not for sale due to a very limited amount at this time.
Return to Home Page


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Healing Touch and Reiki Healings: $180.00
This includes in-office visits and distance healings. Sessions are about forty to fifty minutes on the table. I book clients two hours apart for plenty of time to settle in before the session and integrate the healing after.
Clarity Breathwork Sessions: $230.00
The first session is three hours long. All sessions after are about two and a half hours long.


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To reinvent the thought cycle of students for application based learning
Artificial enables creation of intelligent machines and through the establishment of COE for AI our endeavor is to create Intelligent humans
About the Company & Lab
- AI Lab will play a major role in the research and development commercial and industrial development of emerging AI technologies. The AI Lab will include IBM and other corporate sponsors, coupled with open source technologies viz., NVIDIA, Ubuntu, Redhat, Power9 and Xilinx to accelerate results.
- There is a strong need for research and development activity in these domains:
1. Encouraging academic-industry partnerships.
2. Cross-disciplinary and collaborative research.
3. Making AI accessible to non-technical business students.
4. Enabling faculty-technologist interaction and learning.
5. Enabling startups, ISVs and industries to use the platform to innovate in ways that improve the World condition.
- The IBM OPENpower Lab at NHCE uses IBM POWER9 processor based Server aims to meet the challenging needs of industry, academia, and society in the world of artificial intelligence (AI), machine learning (ML) and deep learning (DL) are identified, AI based hardware and or software systems and support from IBM.
Courses Offered
- E4S Exascale Software training
- Parallelware Analyzer High Performance Computing Training
- Python for Data Science
- Data Analysis with Python
- Machine Learning with Python
- Deep Learning with Tensor Flow
- Hybrid Cloud with Use Cases
- Big Data and Hadoop
Program Highlights
The lab will serve as an excellent platform for:
- Conducting research on rapidly advancing AI technologies
- Enabling and facilitating industry-academia partnerships in research and development, and foster relationships through collaborative projects
- Encouraging cross-disciplinary research in applied computing, in critical scientific and industrial domains, via research proposal submissions to funding agencies
- Providing a state-of-the-art R&D facility for students, faculty and collaborators
- Offering a comprehensive and meaningful computing environment for education by complementing the theoretical coursework with appropriate laboratory coursework for students, and encouraging team participation and cross-disciplinary problem solving.
Hardware setup
- 1 TB SSD for storage
- 32GB DDR4 ECC registered memory
Best Practices
- Talent and Skills: (Remote Interns; Skills and Training) Students and Research scholars will start working on the advanced technologies will enable them to work on many applications.
- Publications and Mindshare: (Press releases, Articles, and Publications; Conferences and Events). Conference Paper on software-based application research /development in 6 months.
- Intellectual Capital: (Patents, Open source; Prototypes, Demos; Curriculum; Student projects, Theses).
- Prototype building of many research problems using software-centric approach (hardware-centric baseline implementation almost getting completed).
- Potential to file disclosures.
- Opportunities: (Seed revenue; Leverage other funding; Build ecosystems; Build government/client relationships). Once software-centric solution available with comparable performance using latest technologies , your team would create prototypes which can be demonstrated to several colleges


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Product Details:
|High Light:
core drill rigs,
diamond core drilling
Flexible Core Drill Rig C6/C6C Core Drilling Rig For Various Drilling Operations
C6/C6C: Flexible surface core drilling rig (second hand. )
The C6 and C6C models represent the most flexible drilling rig size in the Boyles range. They share the same depth capacity of 1 200 m and the powerful feed system, main winch and Tier III low emission engine to enable efficient deep drilling. These two models are differentiated by the mode of transport – the C6 being trailer mounted, while theC6C is crawler mounted.
Drilling rigs offer you at a more favorable price than ever. You are offered a basic rig design that gives you everything that characterises leadership: The power to take on any job with trouble-free operation year after year, paired with a highly competitive cost of ownership.
|Technical Specifications
|Depth capacity
|1540 m
|Product series
|10082 mm
|2602 - 2817 mm
|5302 - 6525 mm
|7000 - 9000 kg
|Rod pull length
|6 m
|Max torque
|5113 Nm
|Max speed
|1300 rpm
|Feeding length
|3.5 mm
|Drill Rod Size
|Main Hoist
|80 kN
|Hole diameter
|48 - 122 mm
Contact Person: Amelia
Tel: 86-18051930311
Fax: 86-510-82752846


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US President; Donald Trump was in attendance at the Young Black Leadership Summit 2019, and interestingly, he met this Cameroonian legal immigrant; Ben Okereke, who ushered the opportunity for Donald Trump to mention Cameroon.
This is how the flow of conversation went:
THE PRESIDENT: With us this afternoon is Ben Okereke. That's a great name. I love that name. When Ben was 14 years old, he legally immigrated to the United States after suffering many hardships in Cameroon, which I hear is a beautiful, beautiful place. Cameroon.
(Audience member cheers.)
THE PRESIDENT: Oh. Wow. (Applause.) One person from Cameroon. (Laughter.)
To give back to our country, he joined the United States Army and honorably served for four years — (applause) — as a very talented field artillery specialist. A lot of talent, they say.
Ben, we salute your noble service. And please say a few words. Ben. (Applause.) Please. All yours.
MR. OKEREKE: Thank you. Thank you, Mr. President. Thank you, Mr. Vice President. And thank you, Charlie Kirk.
First of all, Mr. President, we would like to thank you for everything that you've done for the African American community so far. We thank you for criminal justice reform. We thank you for the lowest black unemployment rate in this country, sir. (Applause.)
And finally, most importantly, sir, thank you for saving America and thank you.
AUDIENCE: Aww!
AUDIENCE MEMBER: It's all right!
MR. OKEREKE: Thank you. Thank you.
Finally, sir, thank you for taking down the fake news media, sir. (Applause.)
Finally, we want you to build a wall, sir. (Laughter.) Frankly, because we don't oppose immigration, but we oppose — but we oppose illegal immigration. So we want you to come to this country legally, if you're going to come to this country. (Applause.) Thank you.
THE PRESIDENT: Thank you, Ben.
MR. OKEREKE: Yes, sir.
THE PRESIDENT: Thank you, Ben. And that's from the heart. That's from the heart. That's what it's all about.
Watch video below:


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Nov 9, 2013
November 9 - Sidney Nebraska to Little America Wyoming
We're a little early for bed, although tired enough from the day. The common thread of the last three days has been the relentless headwinds and this big old flat-sided bushouse doesn't exactly cut through the wind like an F-16. Really, quite the opposite. It's literally like pushing a billboard down the road sideways. Driving is a two hand, two strong arms, and two sharp eyes affair... and don't take those eyes off the road for a second. 9 feet of vehicle in a 12 foot lane provides very little wiggle room as the wind does it's thing. After 400 miles I'm done. Time to park and enjoy the finer things in life... like a double bourbon on the rocks with my sweetie by my side. (Yes Sue, I'm relaxed now.)
Little America is like the big America... only smaller. There's a post office here... a gas station... a restaurant... store... motel... and, perhaps best of all... no Walmart or other irritating big box store. I assume you could live and vote here. You might even be able to run for office. If I were Mayor I'd set up a toll booth at the ramp off I-80 and charge a buck for every vehicle that passes. Considering the remoteness of the place most people would still stop for a tank of gas or a free 50 cent ice cream cone. In any case, we'd have some additional revenue to help keep the place going.
There ain't much to report about Wyoming today. The highlight of the trip was the gradual ascent to the 8640 foot Sherman Summit, the highest point anywhere on I-80, and the not-so-gradual descent into Laramie. Some dramatic and interesting country for sure.
The plan is to continue our string of 400 mile days tomorrow, after which we plan to take a break. We'll be through the area of greatest concern and can slow down a bit... relax even more.
Beyond Branson; Pondering Future Travel
This past Tuesday, we moved from Branson to a very nice Corps of Engineer's Park on Wappapello Lake. We're in the Redman Creek CG. This fac...