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National Institutes of Health (NIH)
Improving Outcomes in Cancer Treatment-Related Cardiotoxicity (R21 Clinical Trial Optional)
R21 Exploratory/Developmental Research Grant
Reissue of PA-18-013
93.393; 93.837
This Funding Opportunity Announcement (FOA) encourages collaborative applications that will contribute to the identification and characterization of patients at risk of developing cancer treatment-related cardiotoxicity. The primary intent is to mitigate cardiovascular dysfunction while optimizing cancer outcomes. To accomplish this, methods that evaluate cardiovascular risk prior to treatment and integrate evidence-based cancer treatment regimens with cardiovascular screening, diagnostic, and/or management strategies are sought. Research applications should focus on mitigation/management of adverse effects associated with anti-cancer treatments including: cytotoxic chemotherapies, targeted agents, immunomodulatory therapies and radiation (that occur during cancer treatment and/or long-term survivorship) as defined by cardiac and/or vascular specific common terminology criteria for adverse events (CTCAE).
December 17, 2018
January 16, 2019
Not Applicable
Standard dates apply, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on these dates.
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
Not applicable
January 8, 2022
Not Applicable
It is critical that applicants follow the Research (R) Instructions in the SF424 (R&R) Application Guide, except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to�all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications�that do not comply with these instructions may be delayed or not accepted for review.
Part 1. Overview Information
Part 2. Full Text of the Announcement
I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information
The purpose of this Funding Opportunity Announcement (FOA) is to stimulate collaborative applications that will contribute to the identification and characterization of patients at risk of developing cancer treatment-related cardiotoxicity with the primary intent to mitigate cardiovascular dysfunction while optimizing cancer outcomes. To accomplish this, methods are sought that evaluate cardiac and vascular risk prior to treatment and integrate evidence-based cancer treatment regimens with cardiovascular screening, diagnostic, and/or management strategies throughout the cancer continuum.
This FOA will utilize the Exploratory/Developmental Grant (R21) mechanism which supports investigation of novel scientific ideas or new model systems, tools or technologies that have the potential for significant impact on biomedical or biobehavioral research. An R21 application need not have extensive background material or preliminary information.
This FOA runs in parallel with an FOA of identical scientific scope, PA-19-112, which utilizes the Research Project Grant (R01) mechanism
The 14 million pediatric and adult cancer survivors living in the United States clearly demonstrate continued improvements in anti-cancer treatment efficacy; however, this success has been tempered by a parallel rise in the incidence of cancer treatment-related toxicity, leading to morbidity and mortality. Cancer treatment-related cardiotoxicity can occur as a consequence of direct effects on cardiac myocytes (function or protective mechanisms) and may include damage to the vascular endothelium, hemodynamic flow alterations and thrombotic events. Cardiotoxicity can present acutely during cancer treatment, potentially limiting dose and reducing the effectiveness of cancer therapy, as well as months or decades after treatment, leading to accelerated treatment-induced cardiovascular disease and early mortality.
Cancer treatments associated with cardiovascular risk include cytotoxic chemotherapies, targeted agents, immunomodulatory therapies and radiation, all of which have different anti-tumor mechanisms and on- and off-target effects that subsequently influence the types of cardiovascular damage observed in patients with cancer. While mechanisms contributing to cardiotoxicity for selected agents have been proposed, few have been explored in the clinical setting that would result in more effective prediction, prevention, detection and management methods for cancer treatment-related cardiotoxicity during cancer treatment and survivorship care. The discovery and increasing use of molecularly targeted cancer therapies, multi-modality treatments, and multi-drug regimens for cancer treatment has widened this knowledge gap and changed the profile of cardiotoxicity in terms of timing and presentation. Current evidenced-based guidelines for preventing and controlling cancer treatment-related cardiotoxicity are broad, based primarily on anthracycline regimen experience and lack specific risk evaluation, prevention, monitoring, and management strategies for subgroups of patients treated with newer therapeutic modalities.
The patient population developing cancer treatment-related cardiovascular injury differs from those with primary cardiovascular dysfunction, underscoring the need for collaboration between oncologists, cardiologists and multidisciplinary team members to maximize cancer and cardiovascular outcomes. Given the heterogeneity among patients with respect to cardiotoxicity risk, timing of onset, clinical presentation, and outcome, the development and translation of individualized cardio-oncology risk stratification, prevention, monitoring, and management plans during cancer treatment and survivorship care is of upmost importance.
Applications submitted to this FOA should focus on mitigation/management of cardiac and/or vascular adverse events associated with anti-cancer treatments (e.g. cytotoxic chemotherapies, targeted agents, immunomodulatory therapies; radiation), including single, repeat and chronic dosing regimens, that occur during cancer treatment and/or throughout the cancer survivorship continuum.
This FOA encourages multidisciplinary collaboration among researchers to 1) develop models to test the efficacy of potential cardiotoxic and cardio-protective agents and therapy combinations; 2) differentiate and quantify characteristics associated with short- and long-term cardiotoxicity; 3) develop and test methods to identify early onset cardiovascular dysfunction; and 4) develop, test and evaluate existing and novel prevention, management and care coordination strategies for cardiotoxicity.
This FOA supports studies that aim to: 1) translate known and emerging clinical profiles, genetic profiles, and biologic mechanisms of cardiotoxicity pathogenesis into improvements in cardiotoxicity risk stratification, prevention and detection; 2) develop and test novel prevention strategies and improve upon known methods; 3) develop and translate therapeutic methodologies for the management of cancer treatment-related cardiotoxicity and 4) focus on understudied cancer populations and emerging treatments. Studies must include one or more translational aim.
Studies on all cardiac and vascular specific common terminology criteria for adverse events (CTCAE) are encouraged and collaboration between oncology and cardiology specialties is required on all applications. Studies solely focused on mechanisms underlying cancer treatment-related cardiotoxicity without a translational aim are not supported by this FOA.
Research topics of interest include, but are not limited to:
See Section VIII. Other Information for award authorities and regulations.
Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.
The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types.
Optional: Accepting applications that either propose or do not propose clinical trial(s)
Need help determining whether you are doing a clinical trial?
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
The combined budget for direct costs for the two-year project period may not exceed $275,000. No more than $200,000 may be requested in a single year.
The maximum project period is 2 years. �
NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this FOA.
Higher Education Institutions
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
Nonprofits Other Than Institutions of Higher Education
For-Profit Organizations
Non-domestic (non-U.S.) Entities (Foreign Institutions) are �eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are �eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are �allowed.
Applicant Organizations
Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.
Program Directors/Principal Investigators (PD(s)/PI(s))
All PD(s)/PI(s) must have an eRA Commons account. �PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.
Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.
This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.
Applicant organizations may submit more than one application, provided that each application is scientifically distinct.
The NIH will not accept duplicate or highly overlapping applications under review at the same time.� This means that the NIH will not accept:
The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.gov Workspace are available in Part 1 of this FOA. See your administrative office for instructions if you plan to use an institutional system-to-system solution.
It is critical that applicants follow the Research (R) Instructions in the SF424 (R&R) Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.
The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this FOA.
All instructions in the SF424 (R&R) Application Guide must be followed. �
All instructions in the SF424 (R&R) Application Guide must be followed. �
All instructions in the SF424 (R&R) Application Guide must be followed. �
All instructions in the SF424 (R&R) Application Guide must be followed.�
All instructions in the SF424 (R&R) Application Guide must be followed.
Travel: Applicants are required to include travel support for an investigator from their research team to attend scientific meetings in Bethesda, Maryland.� Costs associated with travel to one meetings during the life of the grant should be included
All instructions in the SF424 (R&R) Application Guide must be followed.
All instructions in the SF424 (R&R) Application Guide must be followed. �
All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:�
Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide, with the following modification:
Only limited Appendix materials are allowed. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide.
When involving NIH-defined human subjects research, clinical research, and/or clinical trials (and when applicable, clinical trials research experience) follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the SF424 (R&R) Application Guide, with the following additional instructions:
If you answered �Yes� to the question �Are Human Subjects Involved?� on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or Delayed Onset Study record.
Study Record: PHS Human Subjects and Clinical Trials Information
All instructions in the SF424 (R&R) Application Guide must be followed.
Delayed Onset Study
Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start).
All instructions in the SF424 (R&R) Application Guide must be followed.
All instructions in the SF424 (R&R) Application Guide must be followed.�
Foreign (non-U.S.) institutions must follow policies described in the NIH Grants Policy Statement, and procedures for foreign institutions.
See Part 1. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov
Part I. Overview Information contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.
Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH�s electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time. �If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Policy on Late Application Submission.
Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.
Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.
This initiative is not subject to intergovernmental review.
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Pre-award costs are allowable only as described in the NIH Grants Policy Statement.
Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. �Paper applications will not be accepted.
Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.
For assistance with your electronic application or for more information on the electronic submission process, visit How to Apply � Application Guide. If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Dealing with System Issues guidance. For assistance with application submission, contact the Application Submission Contacts in Section VII.
Important reminders:
All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF424(R&R) Application Package. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH. See Section III of this FOA for information on registration requirements.
The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization�s profile in the eRA Commons and for the System for Award Management. Additional information may be found in the SF424 (R&R) Application Guide.
See more tips for avoiding common errors.
Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review, NIH. Applications that are incomplete or non-compliant will not be reviewed.
Applicants are required to follow the instructions for post-submission materials, as described in the policy. Any instructions provided here are in addition to the instructions in the policy.
Only the review criteria described below will be considered in the review process.
Applications submitted to the NIH in support of the NIH mission are evaluated for scientific and technical merit through the NIH peer review system.
The R21 exploratory/developmental grant supports investigation of novel scientific ideas or new model systems, tools, or technologies that have the potential for significant impact on biomedical or biobehavioral research. An R21 grant application need not have extensive background material or preliminary information. Accordingly, reviewers will emphasize the conceptual framework, the level of innovation, and the potential to significantly advance our knowledge or understanding. Appropriate justification for the proposed work can be provided through literature citations, data from other sources, or, when available, from investigator-generated data. Preliminary data are not required for R21 applications; however, they may be included if available.
A proposed Clinical Trial application may include study design, methods, and intervention that are not by themselves innovative but address important questions or unmet needs. Additionally, the results of the clinical trial may indicate that further clinical development of the intervention is unwarranted or lead to new avenues of scientific investigation.
Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).
Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.
Does the project address an important problem or a critical barrier to progress in the field? Is the prior research that serves as the key support for the proposed project rigorous? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
In addition, for applications involving clinical trials
Are the scientific rationale and need for a clinical trial to test the proposed hypothesis or intervention well supported by preliminary data, clinical and/or preclinical studies, or information in the literature or knowledge of biological mechanisms? For trials focusing on clinical or public health endpoints, is this clinical trial necessary for testing the safety, efficacy or effectiveness of an intervention that could lead to a change in clinical practice, community behaviors or health care policy?� For trials focusing on mechanistic, behavioral, physiological, biochemical, or other biomedical endpoints, is this trial needed to advance scientific understanding?
Are the PD(s)/PI(s), collaborators, and other researchers well suited to the project? If Early Stage Investigators or those in the early stages of independent careers, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?
In addition, for applications involving clinical trials
With regard to the proposed leadership for the project, do the PD/PI(s) and key personnel have the expertise, experience, and ability to organize, manage and implement the proposed clinical trial and meet milestones and timelines? Do they have appropriate expertise in study coordination, data management and statistics? For a multicenter trial, is the organizational structure appropriate and does the application identify a core of potential center investigators and staffing for a coordinating center?
Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?
In addition, for applications involving clinical trials
Does the design/research plan include innovative elements, as appropriate, that enhance its sensitivity, potential for information or potential to advance scientific knowledge or clinical practice?
Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project? Have the investigators included plans to address weaknesses in the rigor of prior research that serves as the key support for the proposed project? Have the investigators presented strategies to ensure a robust and unbiased approach, as appropriate for the work proposed? Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed? Have the investigators presented adequate plans to address relevant biological variables, such as sex, for studies in vertebrate animals or human subjects?�
If the project involves human subjects and/or NIH-defined clinical research, are the plans to address
1) the protection of human subjects from research risks, and
2) inclusion (or exclusion) of individuals on the basis of sex/gender, race, and ethnicity, as well as the inclusion or exclusion of individuals of all ages (including children and older adults), justified in terms of the scientific goals and research strategy proposed?��
In addition, for applications involving clinical trials
Does the application adequately address the following, if applicable
Study Design
Is the study design justified and appropriate to address primary and secondary outcome variable(s)/endpoints that will be clear, informative and relevant to the hypothesis being tested? Is the scientific rationale/premise of the study based on previously well-designed preclinical and/or clinical research? Given the methods used to assign participants and deliver interventions, is the study design adequately powered to answer the research question(s), test the proposed hypothesis/hypotheses, and provide interpretable results? Is the trial appropriately designed to conduct the research efficiently? Are the study populations (size, gender, age, demographic group), proposed intervention arms/dose, and duration of the trial, appropriate and well justified?
Are potential ethical issues adequately addressed? Is the process for obtaining informed consent or assent appropriate? Is the eligible population available? Are the plans for recruitment outreach, enrollment, retention, handling dropouts, missed visits, and losses to follow-up appropriate to ensure robust data collection? Are the planned recruitment timelines feasible and is the plan to monitor accrual adequate? Has the need for randomization (or not), masking (if appropriate), controls, and inclusion/exclusion criteria been addressed? Are differences addressed, if applicable, in the intervention effect due to sex/gender and race/ethnicity?
Are the plans to standardize, assure quality of, and monitor adherence to, the trial protocol and data collection or distribution guidelines appropriate? Is there a plan to obtain required study agent(s)? Does the application propose to use existing available resources, as applicable?
Data Management and Statistical Analysis
Are planned analyses and statistical approach appropriate for the proposed study design and methods used to assign participants and deliver interventions? Are the procedures for data management and quality control of data adequate at clinical site(s) or at center laboratories, as applicable? Have the methods for standardization of procedures for data management to assess the effect of the intervention and quality control been addressed? Is there a plan to complete data analysis within the proposed period of the award?
Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?��
In addition, for applications involving clinical trials
If proposed, are the administrative, data coordinating, enrollment and laboratory/testing centers, appropriate for the trial proposed?
Does the application adequately address the capability and ability to conduct the trial at the proposed site(s) or centers? Are the plans to add or drop enrollment centers, as needed, appropriate?
If international site(s) is/are proposed, does the application adequately address the complexity of executing the clinical trial?
If multi-sites/centers, is there evidence of the ability of the individual site or center to: (1) enroll the proposed numbers; (2) adhere to the protocol; (3) collect and transmit data in an accurate and timely fashion; and, (4) operate within the proposed organizational structure?
As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact score, but will not give separate scores for these items.
Study Timeline
Specific to applications involving clinical trials
Is the study timeline described in detail, taking into account start-up activities, the anticipated rate of enrollment, and planned follow-up assessment? Is the projected timeline feasible and well justified? Does the project incorporate efficiencies and utilize existing resources (e.g., CTSAs, practice-based research networks, electronic medical records, administrative database, or patient registries) to increase the efficiency of participant enrollment and data collection, as appropriate?
Are potential challenges and corresponding solutions discussed (e.g., strategies that can be implemented in the event of enrollment shortfalls)?
For research that involves human subjects but does not involve one of the� categories of research that are exempt under 45 CFR Part 46, the committee will evaluate the justification for involvement of human subjects and the proposed protections from research risk relating to their participation according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained, and 5) data and safety monitoring for clinical trials.
For research that involves human subjects and meets the criteria for one or more of the� categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. For additional information on review of the Human Subjects section, please refer to the Guidelines for the Review of Human Subjects.
When the proposed project involves human subjects and/or NIH-defined clinical research, the committee will evaluate the proposed plans for the inclusion (or exclusion) of individuals on the basis of sex/gender, race, and ethnicity, as well as the inclusion (or exclusion) of individuals of all ages (including children and older adults) to determine if it is justified in terms of the scientific goals and research strategy proposed. For additional information on review of the Inclusion section, please refer to the Guidelines for the Review of Inclusion in Clinical Research.
The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following criteria: (1) description of proposed procedures involving animals, including species, strains, ages, sex, and total number to be used; (2) justifications for the use of animals versus alternative models and for the appropriateness of the species proposed; (3) interventions to minimize discomfort, distress, pain and injury; and (4) justification for euthanasia method if NOT consistent with the AVMA Guidelines for the Euthanasia of Animals. Reviewers will assess the use of chimpanzees as they would any other application proposing the use of vertebrate animals. For additional information on review of the Vertebrate Animals section, please refer to the Worksheet for Review of the Vertebrate Animal Section.
Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.
For Resubmissions, the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project.
Not Applicable
For Revisions, the committee will consider the appropriateness of the proposed expansion of the scope of the project. If the Revision application relates to a specific line of investigation presented in the original application that was not recommended for approval by the committee, then the committee will consider whether the responses to comments from the previous scientific review group are adequate and whether substantial changes are clearly evident.
As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.
Reviewers will assess whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions that exist in other countries and either are not readily available in the United States or augment existing U.S. resources.
Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).
Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not sharing the following types of resources, are reasonable: (1) Data Sharing Plan; (2) Sharing Model Organisms; and (3) �Genomic Data Sharing Plan (GDS).
For projects involving key biological and/or chemical resources, reviewers will comment on the brief plans proposed for identifying and ensuring the validity of those resources.
Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.
Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by Center for Scientific Review, in accordance with NIH peer review policy and procedures, using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons.
As part of the scientific peer review, all applications:
Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications submitted to this FOA. Following initial peer review, recommended applications will receive a second level of review by the appropriate national Advisory Council or Board. The following will be considered in making funding decisions:
After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons.�Refer to Part 1 for dates for peer review, advisory council review, and earliest start date.
Information regarding the disposition of applications is available in the NIH Grants Policy Statement.
If the application is under consideration for funding, NIH will request "just-in-time" information from the applicant as described in the NIH Grants Policy Statement.
A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee�s business official.
Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.
Any application awarded in response to this FOA will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website.� This includes any recent legislation and policy applicable to awards that is highlighted on this website.
�Individual awards are based on the application submitted to, and as approved by, the NIH and are subject to the IC-specific terms and conditions identified in the NoA.�
ClinicalTrials.gov: If an award provides for one or more clinical trials. By law (Title VIII, Section 801 of Public Law 110-85), the "responsible party" must register and submit results information for certain �applicable clinical trials� on the ClinicalTrials.gov Protocol Registration and Results System Information Website (https://register.clinicaltrials.gov). NIH expects registration of all trials whether required under the law or not. For more information, see http://grants.nih.gov/ClinicalTrials_fdaaa/�
Institutional Review Board or Independent Ethics Committee Approval: Grantee institutions must ensure that the application as well as all protocols are reviewed by their IRB or IEC. To help ensure the safety of participants enrolled in NIH-funded studies, the awardee must provide NIH copies of documents related to all major changes in the status of ongoing protocols.� Data and Safety Monitoring Requirements: The NIH policy for data and safety monitoring requires oversight and monitoring of all NIH-conducted or -supported human biomedical and behavioral intervention studies (clinical trials) to ensure the safety of participants and the validity and integrity of the data. Further information concerning these requirements is found at http://grants.nih.gov/grants/policy/hs/data_safety.htm and in the application instructions (SF424 (R&R) and PHS 398).
Investigational New Drug or Investigational Device Exemption Requirements: Consistent with federal regulations, clinical research projects involving the use of investigational therapeutics, vaccines, or other medical interventions (including licensed products and devices for a purpose other than that for which they were licensed) in humans under a research protocol must be performed under a Food and Drug Administration (FDA) investigational new drug (IND) or investigational device exemption (IDE).�
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General� and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.
Recipients of federal financial assistance (FFA) from HHS must administer their programs in compliance with federal civil rights law. This means that recipients of HHS funds must ensure equal access to their programs without regard to a person�s race, color, national origin, disability, age and, in some circumstances, sex and religion. This includes ensuring your programs are accessible to persons with limited English proficiency.� HHS recognizes that research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigator�s scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research.
For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this FOA. HHS provides general guidance to recipients of FFA on meeting their legal obligation to take reasonable steps to provide meaningful access to their programs by persons with limited English proficiency. Please see https://www.hhs.gov/civil-rights/for-individuals/special-topics/limited-english-proficiency/index.html. The HHS Office for Civil Rights also provides guidance on complying with civil rights laws enforced by HHS. Please see https://www.hhs.gov/civil-rights/for-individuals/section-1557/index.html; and https://www.hhs.gov/civil-rights/for-providers/laws-regulations-guidance/index.html. �Recipients of FFA also have specific legal obligations for serving qualified individuals with disabilities. Please see https://www.hhs.gov/civil-rights/for-individuals/disability/index.html. Please contact the HHS Office for Civil Rights for more information about obligations and prohibitions under federal civil rights laws at https://www.hhs.gov/ocr/about-us/contact-us/index.html or call 1-800-368-1019 or TDD 1-800-537-7697. Also note it is an HHS Departmental goal to ensure access to quality, culturally competent care, including long-term services and supports, for vulnerable populations. For further guidance on providing culturally and linguistically appropriate services, recipients should review the National Standards for Culturally and Linguistically Appropriate Services in Health and Health Care at http://minorityhealth.hhs.gov/omh/browse.aspx?lvl=2&lvlid=53.
In accordance with the statutory provisions contained in Section 872 of the Duncan Hunter National Defense Authorization Act of Fiscal Year 2009 (Public Law 110-417), NIH awards will be subject to the Federal Awardee Performance and Integrity Information System (FAPIIS) requirements.� FAPIIS requires Federal award making officials to review and consider information about an applicant in the designated integrity and performance system (currently FAPIIS) prior to making an award.� An applicant, at its option, may review information in the designated integrity and performance systems accessible through FAPIIS and comment on any information about itself that a Federal agency previously entered and is currently in FAPIIS.� The Federal awarding agency will consider any comments by the applicant, in addition to other information in FAPIIS, in making a judgement about the applicant�s integrity, business ethics, and record of performance under Federal awards when completing the review of risk posed by applicants as described in 45 CFR Part 75.205 �Federal awarding agency review of risk posed by applicants.�� This provision will apply to all NIH grants and cooperative agreements except fellowships.
Cooperative Agreement Terms and Conditions of Award
Not Applicable
When multiple years are involved, awardees will be required to submit the Research Performance Progress Report (RPPR) annually and financial statements as required in the NIH Grants Policy Statement.
A final RPPR, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement.
The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later.� All awardees of applicable NIH grants and cooperative agreements�are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000.� See the NIH Grants Policy Statement for additional information on this reporting requirement.
In accordance with the regulatory requirements provided at 45 CFR 75.113 and Appendix XII to 45 CFR Part 75, recipients that have currently active Federal grants, cooperative agreements, and procurement contracts from all Federal awarding agencies with a cumulative total value greater than $10,000,000 for any period of time during the period of performance of a Federal award, must report and maintain the currency of information reported in the System for Award Management (SAM)�about civil, criminal, and administrative proceedings in connection with the award or performance of a Federal award that reached final disposition within the most recent five-year period.� The recipient must also make semiannual disclosures regarding such proceedings.�Proceedings information will be made publicly available in the designated integrity and performance system (currently FAPIIS).� This is a statutory requirement under section 872 of Public Law 110-417, as amended (41 U.S.C. 2313).� As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on or after April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly available.� Full reporting requirements and procedures are found in Appendix XII to 45 CFR Part 75 � Award Term and Conditions for Recipient Integrity and Performance Matters.
We encourage inquiries concerning this funding opportunity
and welcome the opportunity to answer questions from potential applicants.
eRA Service Desk (Questions regarding ASSIST, eRA Commons, application errors and warnings, documenting system problems that threaten submission by the due date, and post-submission issues)
Finding Help Online:�http://grants.nih.gov/support/�(preferred
method of contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)
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(Questions regarding application instructions, application processes, and NIH
grant resources)
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Contact Center Telephone: 800-518-4726
Nonniekaye Shelburne, MS, CRNP, AOCN
National Cancer Institute (NCI)
Telephone: 240-276-6897
Email: firstname.lastname@example.com
Patrice Desvigne-Nickens, M.D.�
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0504
Examine your eRA Commons account for review assignment and contact information (information appears two weeks after the submission due date).
Carol Perry
National Cancer Institute (NCI)
Telephone: 240-276-6282
Email: firstname.lastname@example.com
Tyrone Smith
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-827-8053
Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Part 75.
Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.


text:
Experience the allure of fire like never before with AZ Patio Heaters Reflective Fire Glass. In a world where tradition meets innovation, this exquisite fire glass takes center stage. Bid farewell to mundane ceramic logs and fire stones, and step into a realm of mesmerizing beauty.
Crafted for those who seek elegance in every flicker, our Reflective Fire Glass transforms ordinary fire features into extraordinary works of art. Imagine flames dancing gracefully over a bed of glistening glass, creating an enchanting spectacle that captures hearts and ignites conversations.
This isn't just any fire glass; it's a statement of sophistication. Whether you're a homeowner looking to redefine your space or a designer seeking to inspire, this copper-hued marvel is your canvas. Mix and match colors to craft unique designs, play with levels, and watch as the fire gracefully weaves its magic through the glass. Your fire pit will never be the same.
- Mesmerizing Beauty: Watch as flames dance elegantly over reflective glass, creating a captivating display that enchants onlookers.
- A Modern Touch: Elevate your fire feature, giving it a contemporary edge that transforms your space.
- Efficient Heat Distribution: The reflective properties of this glass ensure even heat distribution, keeping you warm and cozy.
- Hassle-Free Cleanup: Say goodbye to the mess of traditional logs and stones; our fire glass is easy to maintain.
- Lasting Durability: Crafted to withstand the rigors of heat, AZ Patio Heaters Reflective Fire Glass is built to last.
- Endless Creativity: Mix and match colors and levels to create your unique fire display.
- Multiple Options: Available in 10 or 20 lbs, choose the 10lb option for most fire pits, and let the magic unfold.
- Reflective fire glass for fire pits
- Copper color
- 0.25" - 0.5" diameter
- Choose from 10 or 20 lbs
- 20lbs is recommended for most fire pits
About The Manufacturer:
AZ Patio Heaters was established in 2002. We have devoted an enormous amount of time to developing our Patio Heater line in the US with the support of our manufacturer. Our manufacturer has been producing patio heaters for over 10 years. Over the years we have taken the necessary steps to insure quality control and produce a consumer-friendly product that is reliable and trouble free.
At Belleflame, we believe that shopping should be simple, stress-free, and most importantly, enjoyable. That's why we work hard to bring you the best products, prices, and customer service in the industry.
Here are just a few reasons why you should choose us:
- Wide Selection of Products: We offer a vast selection of top-quality products from the leading brands in the industry. No matter what you're looking for, we have something for everyone.
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- Easy Returns: We want you to be completely satisfied with your purchase. If for any reason you're not happy, just let us know and we'll make it right.
Order Confirmation:
Upon placing your order, you will promptly receive an email confirmation. Subsequently, we will conduct a thorough inventory check to ensure all items are in stock and available for immediate shipment. If your order aligns with the advertised delivery timeframe, we will promptly process it for shipment to our warehouse. In cases where the expected delivery time extends beyond the advertised timeframe, we will reach out to you via email and/or phone for confirmation.
Order Shipment:
Within one business day of your item being shipped, you will receive an email confirmation containing a tracking number. If you do not receive tracking information within six business days of placing your order, please don't hesitate to get in touch with us for assistance.
Estimated Time of Arrival:
Our typical delivery timeframe ranges from 2 to 10 business days. Custom-made products generally require 3 to 5 weeks for delivery. If the expected delivery date for your order would fall outside of the advertised 2-10 business day time frame, our customer service team will contact you to ensure your agreement with the revised timeline.
Covered Areas:
Please note that all estimated delivery dates and shipping costs advertised on our website apply exclusively to the Contiguous United States. For inquiries regarding shipping to Hawaii or Alaska, kindly reach out to our customer service team. While we do not offer direct shipping to Canada, we are more than willing to ship your order to the freight carrier of your choice.
It is very important that you inspect the packaging of your items when they arrive and check if you received all boxes listed on the delivery receipt. If you notice any damage or shortage of packages, you must make note of it on the bill of lading, take pictures, and refuse delivery. Your note should say "refused due to damage". You must also take photos of all sides of the box and send them to us within 2 days. If there are no damages visible before opening the box, you must note "subject to further inspection may contain concealed damage". If you notice any damage after receiving the delivery, do not throw the box away, and contact us with the photos. After we receive information from you about the refused delivery or concealed damage, we immediately initiate a claim with the shipping company or with the manufacturer. After the claim is fully processed, we ship all replacements at absolutely no cost to you.
Cancellations & Refunds:
We offer free order cancellations before the shipping label or Bill of Lading is generated, or prior to the commencement of production for custom orders. Please note that custom-made items are not eligible for refunds once production has begun. To be eligible for a return, the item must be unused and in its original condition, with all packaging intact and in perfect condition. Orders delivered outside of the United States are not eligible for refunds. If your order arrives damaged, please refer to the "Damages" section. Our refund policy extends for 30 days. If 30 days have elapsed since your purchase, regrettably, we cannot process a refund. Prior to returning an item, please contact us to discuss shipping details. All refunds will be credited to the original credit card or PayPal account used for the purchase, within two days of receiving the returned items at our warehouse.
Please contact firstname.lastname@example.com for any questions regarding shipping time.
At Belleflame, we're committed to providing our customers with the best prices on the market. That's why we offer a 110% best price guarantee. If you find a better deal on the same product somewhere else, just let us know and we'll beat it by an additional 10%.
We believe that shopping should be easy, convenient, and most importantly, affordable. That's why we work hard to bring you the lowest prices on the products you love. But if you do happen to find a better deal elsewhere, we'll go the extra mile to make sure you get the best deal possible.
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100% Guaranteed Secure Checkout
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

subset: commoncrawl


text:
Size of large design 104x140mm (T-shirts)
Below select a product to which you want to print design 1357 - TRHNI SI NOHOU
You chose design TRHNI SI NOHOU and now just click on something creative from a wide range of products UAX fish without meat!
Scroll down on this page and you receive a lot of products that you print this, TRHNI SI NOHOU we can prepare.
Work on the production of this unique original will take 10 working days.
In the first stage , ie 1-4 days seamstresses ready in accordance with the selected color and size of the stock and follows the first quality check before being admitted to the printer. 5-7 days team of experienced printers in your design TRHNI SI NOHOU by screen printing prints by hand him over netting pushed strongly into the fabric. Because we want products UAX withstand rougher treatment , to transfer images to textiles we use this manual method , laborious and expensive screen printing. Thus, the printer selected image FOLOW YOUR HEART prepare to be on a sweatshirt , t-shirt , shorts , polo shirt, purse , laptop bag or perhaps a colorful planter. In the last stage eight days again passes control product quality for the expedition , and here to order printed TRHNI SI NOHOU packed in the original cardboard box , pack your fix with UAX design a bumper sticker.
Click below to Czech product with design TRHNI SI NOHOU
Be original and do not go with the crowd!
T-shirt printed with 1357 - TRHNI SI NOHOU is cool!
E-mail: email@example.com
phone: +420 731 574 676
Mo-Fri: 7:00 - 15:00
UAX s.r.o.
Bernartice nad Odrou 131
741 01 Czech republic


text:
Available Aggressive Sporty Front Fascia
Highlighted by its honeycomb mesh grille, Corolla's lower, wider, more aggressive stance stands out for all the right reasons.
Available 18-in. Machined Alloy Wheels
The available 18-in. Machined alloy wheels1, the largest ever offered for Corolla, add to its unapologetic profile.
Standard LED Headlights with DRL and LED Taillights
Distinctive lights. Enhanced efficiency. Corolla's headlights feature LED Daytime Running Lights (DRL) and its LED taillights light up with an iconic look.
Available Dark Gray Metallic Sport Accents
With an available Dark Gray Metallic rear spoiler, diffuser and side rocker panels, you'll make a strong impression wherever you pull up.
All-New Spacious Interior
Corolla's premium and open interior isn't just nice to sink into. The controls and seats were positioned in a way that increases visibility for a more exciting driving experience.
All-New Premium Interior
Step inside and you'll feel the difference. Corolla's all-new interior is comfortable, clean and designed with you in mind.
Available SofTex® Sport Seats
Redesigned top to bottom, the mixed-media sport seats with SofTex® bolsters and premium fabric inserts work together to make you feel comfortable and in control behind the wheel.2
Available Leather-Wrapped Steering Wheel
Even your fingertips will feel the difference when you grab hold of Corolla's available leather-wrapped steering wheel.
Available Moonroof
Free your cabin with better airflow and more natural light from above with Corolla's available moonroof.
Available Soft-Touch Interior and Piano-Black Accents
Available piano-black accents and available soft-touch materials on the dash and doors surround you and your passengers with premium comfort and polish that's unexpected for a compact sedan.
Standard Apple CarPlay® Compatibility
Apple CarPlay®3 works with your IPhone®4 so you can get directions, send messages or make calls with your voice through Siri® Eyes Free,5 and listen to music—all while staying focused on your drive.
Standard Audio with an Available 8-in. Touch-Screen Display
Cast onto a large 8-in. in-dash display and an available 800-watt JBL®6 nine-speaker system, you'll find even more reasons to take the long way home.
Amazon Alexa Compatibility
With the Toyota+Alexa app7, you can ask to play music, control smart home devices, find parking and more—Alexa will respond instantly. And while using Corolla's available Remote Connect app8 with the Toyota skill for Alexa enabled9 you can unlock doors, start the engine, and check the status of your vehicle from your Alexa built-in device at home.
Available Blind Spot Monitor
By illuminating a warning signal on the applicable outside mirror, the available Blind Spot Monitor (BSM)10 can help alert you to vehicles that may be hiding in your blind spot.
Available Remote Connect
Remotely locate your Corolla in a crowded lot, start the engine and more with the available Remote Connect app11 that works with your Apple Watch®12 and other smart devices. Apple Watch® shown.
Available Adaptive-Front Lighting System
Corolla's tech is more than just convenient, it is designed to keep you safe. The available Adaptive-Front Lighting System (AFS)13 follows your front wheels when you turn for enhanced visibility at night.


text:
Post Discussion About Software/CABs, Tweaks, Games And Emulators Here
Use this control to limit the display of threads to those newer than the specified time frame.
Allows you to choose the data by which the thread list will be sorted.
Order threads in...
Note: when sorting by date, 'descending order' will show the newest results first.


text:
Welcome to our website! As we have the ability to list over one million items on our website (our selection changes all of the time), it is not feasible for a company our size to record and playback the descriptions on every item on our website. However, if you have a disability we are here to help you. Please call our disability services phone line at (214) 638-2681 during regular business hours and one of our kind and friendly personal shoppers will help you navigate through our website, help conduct advanced searches, help you choose the item you are looking for with the specifications you are seeking, read you the specifications of any item and consult with you about the products themselves. There is no charge for the help of this personal shopper for anyone with a disability. Finally, your personal shopper will explain our Privacy Policy and Terms of Service, and help you place an order if you so desire.
Open to the Public
Monday - Friday: 9AM to 430PM
Saturday: 10 AM to 4 PM
Capital Distributing in Dallas, TX is an authorized dealer of Whirlpool Products. Whirlpool advances technology to the point of Simplicity. Creating innovation that's forward thinking. Great design that fits seamlessly into life and is truly a pleasure to live with.
In many Whirlpool appliances, remarkable sense and adapt technology responds to the needs of your clothes, your meals and your foods. By adapting to each situation, intuitive sensors make key refinementsprecisely adjusting water levels for the best clean possible or measuring moisture content for better baking. So your fabrics look newer longer, meals cook more evenly, and foods stay cool and flavorful.
Advanced performance means getting great results while using less water and energy. Their ENERGY STAR® qualified appliances deliver eco-efficient operation that exceeds the toughest government standards.
So if you are looking for Whirlpool products in Dallas, Ft Worth, Southlake, Colleyville, Highland Park, University Park, Plano, Carrollton, Allen, Richardson and Irving, or if you have any questions about Whirlpool products, please feel free to call us at (214) 638-2681 or simply stop by Capital Distributing at any time and we would be glad to help you.


text:
Fourth edition
"Community and local development
Building strategies for local development"
15 - 26 July 2013, Trento, Italy
OECD LEED Trento Centre
in collaboration with the Trentino Federation of Cooperatives
Background / Objectives / Issues&Contents / Methodology / Selection / Contacts
The OECD LEED Trento Centre for local development , the Training Centre for International Cooperation (TCIC) and EAFIT University of Medellin in cooperation with the Trentino Federation of Cooperatives have set up in 2010 a joint "International Summer School for cooperation and local development". The main scope of the Summer School is the promotion of local development, by the understanding and acknowledgment from public and private actors of the factors which contribute to build local development strategies, stating from the concept of "territorial capital" and its dimensions. These are considered the base for any development process aiming at guaranteeing better lives for their community.
The role and the strategic capacity of local actors, the commitment to collaborate and coordinate actions towards the design of a "shared future" represent key elements of development processes rooted in local contexts in which the differences should be exploited as opportunities rather than being considered barriers. This is the condition for the development of strong relationships between regions and communities. There is the need to design development strategies with multi-dimensional character, able to capture the different dimensions - cognitive, social and governance, infrastructure, ecosystem - that create the "territorial capital" and that allow communities to address global challenges, increasing their ability to adapt to economic, social and environmental changes.
It is essential for local actors to have the ability to develop knowledge and skills to promote regional partnerships based on integrated policies and to be able to developing their own human, environmental and institutional resources.
|Sharing concepts and ideas on sustainable local development based on comparison of local experiences form Trentino and Latin America, looking for new strategic syntheses.
Providing tools for reading and understanding the selected local experiences from Latin America and Europe, identifying and analysing the lesson learned with respect to the development of dynamics of local development based on the existing territorial capital.
Establish and experiment with an international common platform, based on ICT, which enhances the efficiency, effectiveness and extent of exchange of knowledge and experiences about local development.
The 2013 Summer School is organised around the understanding and acknowledgment of the factors which contribute to build local development strategies, stating from the concept of "territorial capital" and its dimensions:
Cognitive capital.
Social capital.
Eco-systemic capital.
Infrastructure capital.
These represent a cross-disciplinary approach to the characteristics of a territory necessary in any local context to enable it to build its own strategy for sustainable economic, social, environmental and institutional development.
Summer school brochure (available in Spanish and Italian only)
General characteristics
The Summer School is based on active exchange of experiences and multi-stakeholder dialogue. The case study presented in the on-line registration form should be considered as background for the working groups during the course.
- Personal and professional experiences.
- Motivations to participate in the Summer School.
- A case study (project, programme or initiative currently implemented or recently being completed – no more than 5 years- which is directly related to the applicant's professional experience).
The Summer School is organised in co-operation with EAFIT University from Medellin (Colombia) to which were reserved 50% of the 30 places available. The selection process of applicants from other entities is therefore for 15 places and is open to candidates from all countries of Latin America. The organisers will to secure a balanced and varied classroom composition.
|The deadline for completing the on-line registration process is the 5 of April 2013 at 24.00 (Italian time).
The selection process will be finalised by the 22 of April 2013.
The participation will be considered confirmed once the registration fee will be received by the organisers and with the deadline of 6 of May 2013.
The Summer School will take place from Monday 15 to Friday 26 of July 2013 included.
Trento, Italia.
The following costs of participation in Trento are covered by the organisers:
The participants or their belonging organisations should cover:
For more information, please contact email@example.com and email@example.com.
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We're on call 24/7 to react promptly to your blocked toilet.
Few reasons to choose us
NO HIDDEN COSTSWe are clear and upfront about our prices. We never charge extra for London Congestion or traveling to the job site. We may charge you for parking our vans at certain locations, but other than that the rate we quote is the rate you pay. It's as simple as that!
1 YEAR GUARANTEEAll repairs and installations carried out by our expert plumbers and gas engineers are guaranteed for 12 months. Reported issues are always treated as priority by our customer service team, and are rectified as soon as possible.
GAS SAFE ENGINEERSOur Gas Safe registered engineers undergo a rigorous training before they are allowed to work on gas appliances unsupervised. We monitor our engineers to make sure they stay up to date with latest industry standards and regulations.
QUICK EMERGENCY RESPONSEWe understand that plumbing and heating emergencies can be very frustrating. That's why our trained plumbers and heating engineers are available 24 hours a day, 7 days a week. In case of an emergency, our customer service team will allocate an engineer that is closest to your location. The average waiting time is less then an hour.
24/7 AVAILABILITYWe are available for call outs 24 hours a day, 7 days a week. With a fleet of fully stocked plumbing vans located in your area, we can normally reach you in less then 1 hour.
FREE ESTIMATESWe provide free, non-obligation estimates for large plumbing and heating projects including: boiler and central heating installations, kitchen and bathroom installations and commercial boiler installations. Contact us for more details on how to obtain your free estimate.
Blocked Toilet London Plumbers
A clogged bathroom London may be a significant annoyance and understandably you require it solved as speedily as possible, our experienced and qualified engineers can easily unblock your bathroom in London .
When you flush your toilet and the pan begins to fill up using the waste water and rises towards the rim and then gradually returns back to its initial water level that is a toilet?with a blockage in London .
Normally the blockage will probably be from the bathroom itself or at the instant pipework behind the bathroom, this is the most frequent spot for the congestion to be found.
If the congestion isn't located on the bathroom side then the blockage is going to be found on the exterior this construction.
The congestion will be from the sub surface seams and also will have to get unblocked from an entry point like a guy hole or rodding eyecatching.
We are London plumbers
We are a group of local plumbers and gas engineers. We have combined experience of over 100 years. We can help you with all your plumbing, heating and drainage related problems.
Commercial Plumbing
Does your business need a maintenance company you can rely on? As our loyal commercial customers can tell you, whether its fixing a small leak from your hairdressers basin or the installation of your hotels new central heating system, we can guarantee a specialised, courteous and reasonably priced service. Shops, bars, restaurants, schools, warehouses, fast food outlets, care homes, offices, charities ? the list goes on and on! Wherever we are needed, we will get the job done right, and done right first time!
Our friendly and professional domestic plumbers can fix everything from a leaking sink and a broken tap to a complex central heating and hot water system. We can also supply and fit new sinks, baths, toilets and bidets, or install gas and electric boilers and hot water cylinders. Call us now for a same-day fix or installation!
WELCOME TO London PLUMBERS
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- Boiler Servicing
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Emergency Leaks & Pipe Bursts
If you have got a plumbing emergency, simply call our 24 hour customer service team
020 8719 0160 OR Contact Us
Featured Services
Plumbing Leaks
Bathroom Plumbing
Kitchen plumbing
Blocked Toilet London Plumbers – Overview
Normally, in the event the manhole is clear, the pipes resulting in your house is going to be the origin of the blockage. The next thing to do is to examine the pipes for some leaks due to cracks. It's important to have these pipes in London . The truth is that the majority of the moment, it can result in pipes to rust which causes leakage. A leaking pipe London is a significant issue that must be dealt immediately. You certainly would rather not take care of busted pipes so you need to earn a thorough inspection first prior to opening your outdoor faucet. In case a broken valve is the reason for the issue, might too replace it.
A leaking faucet London can waste as much drinking water in one day as the total necessary to sustain 1 person for a whole week. When a sink becomes clogged up in your house, fixing the issue on your own can be a simple task. You may be asking yourself how a sink or pipe becomes blocked up to start with. Toilets are a standard supply of unnoticed leaks in London . Watch out for bleeding when you use the toilet, or when you see that you are starting to bruise easily or cuts aren't going to quit bleeding for a very long moment. Showers are frequently an important portion of our day, therefore it's important our shower's plumbing is in order. Only after you escape from the shower you see the water beginning to retreat.
You must seek the services of a plumber London ?for immediate way to solve the drain cleaning issue. With so many possible problems about the toilet, it's highly recommended to hire a plumber London ?to decide what's exactly wrong-and then repair the problem. Your solution is ensuring your plumber has the capacity of CCTV. Plumbers London ?provide you with the right type of maintaining and servicing that may block you from this kind of blockage that might lead to delay of your work. There are various procedures that the plumber London ?can use so as to unclog the drain. A neighborhood plumber needs to be contacted immediately to prevent more damage. You are going to want to seek advice from a knowledgeable London plumber who's familiarized with London Area soil.
Trenchless sewer repair has turned into an alternative to these standard techniques, and for several reasons is now an extremely common option. Sewer cleaning is the sole remedy to a lot of drain difficulties. In the majority of our homes, drain cleaning has been happening for a while now. Therefore, constant drain cleaning is vital to protect against any type of accidents.
In case the water isn't draining correctly, it will probably be caused by a blocked drain. Once it has been shut off, inspect the rest of the pipes for potential problems. Now you have to make sure there is water in the bowl itself. In your house, running water is a significant portion of so many tasks. To begin with, you may be interested in exactly how much water you are using each day. If you're able to, allow as much water as possible to drain from the bowl. Utilizing the drain and pouring more water is only going to worsen the issue, making it more challenging to resolve.
Unblocking a drain London ?should be done whenever possible. Unblocking a drain isn't as simple as it sounds to be. Sometimes, however, a clogged drain isn't easily preventable especially if there are lots of individuals utilizing the kitchen and the bathroom. It does not happen by itself. A blocked drain London ?can be on account of many different reasons. If you're experiencing a blocked drain London, be sure that you don't utilize it until the issue is resolved.
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All content on this site is protected by copyright. The educational resources on this site may be used, reproduced and distributed by instructors for non-commercial, educational purposes without additional permission. Any other reproduction or use of content from this site requires the user to obtain copyright clearance.
Title: Rene Daumal Portrait series
Artist: Al Neil
Date: 1992
Format: Collage
Location: Collection of Al Neil and Carole Itter
Size: 56.00 × 75.00 cm
More Information: Collection of Al Neil and Carole Itter.Further Research: Al Neil
Discrete project sites documenting the work of specific artists and collectives in detail.
Essays and conversation providing a context for exploring the Project Sites and Archives.
Video interviews conducted between December 2008 and May 2009 reflecting on Vancouver's art scene in the sixties.


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Dokkedal (North)
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Camera Summary
This permanent live traffic camera is positioned at Dokkedal facing north. It is operational 24/7 and is currently online.
There are no known permanent live traffic, weather or surf cameras situated within 5km of this traffic camera.
Traffic footage from this webcam is updated every minute with footage supplied by Vejdirektoratet.
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Camera Details
- Status: Online
- Camera Type: Traffic camera
- Direction: North
- Lat/long: 56.914603, 10.255523
- GPS Coordinates: 56°54'52"N, 10°15'19"E
- Archives filesize: -
- Region: Denmark
Nearby Cameras
There are no nearby cameras.


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Complete Service Repair Workshop Manual.
Service Repair Workshop Manual, available for instant download to your computer, tablet or smart phone.
This Professional Manual covers all repairs, servicing and troubleshooting procedures. It is very detailed and contains hundreds of pages with detailed photos & diagrams.
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Airway Management Trainers
Designed for realistic practice of airway management skills.
Key to the circle of learning, skills proficiency enables healthcare providers to build confidence and competence and ensure the highest quality patient care. Using skills trainers with our SimPad PLUS or LLEAP products helps educators build or adapt standardized training scenarios into the learning curriculum.
The only training program that offers everything you need to get learners up to speed quickly from basic to advanced ventilation management.
Products dedicated to increasing survival rates from sudden cardiac arrest.
Solutions supporting the practice of vascular and arterial access procedures.


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Attend upcoming events at The Norva with the help of the TixBag Tickting marketplace. Use the various Event page filter options to sort The Norva tickets according to specific criteria such as category, time of day, day of the week, and month. Once you've settled on an event, press "Tickets" to view the The Norva seating chart displaying the anticipated layout for the event (subject to change). Use the event schedule on this page to find an upcoming Event, and then click the red "Tickets" tab to view pricing and seating information on the next page. Our Dedicated customer service team will be available every step of the way either by phone (866) 966-8445 or Live Chat should you have any questions or need assistance making a purchase. A 100% Buyer Guarantee backs all confirmed orders, ensuring a prompt delivery of authentic The Norva tickets.
The interactive The Norva seating chart will be featured alongside the listings for the event you'll be attending. Using the customized seating charts, uncover open sections of the venue and compare prices by clicking any of the colored areas on the map to call up the corresponding details. You'll also be able to reveal the quantity available and set your own price range to further narrow down The Norva seating options.
Browse the full offering of The Norva tickets, or filter by price, section, row, or quantity until you find the listing that meets your needs. To proceed to checkout, click the "Buy Ticket" button. Once logged in, you'll be able to complete fields for payment and shipping before verifying that all details of the The Norva tickets order are accurate.


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If this server is having problems to connect to courier tracking server or the result of your parcel tracking not showing up, Please select this server Track SFC Service
SFC Service has a lot profesional team to handle your parcels, your parcels will be send by plane, car or mortorcycle with fast as soon as possible to destination according to the services available. Enter your tracking code between 10 and 40 digits long shown on your SFC Service shipping receipt and click on Track to follow the progress of your shipment.
Open your receipt, read and find a long string unique id then enter your SFC Service tracking number or tracking code above then click track. you will get a lot of information of details from where to where your parcelss in real-time updates of transit of visibility, location, condition, shipping history, regulation, reference and printable version of the Proof of Delivery.
If your parcelss dont have access to a tracking number, you can track your shipments online with main tracking page by the reference number assigned to your shipment and SFC Service will be able to locate your parcels when you select the track button. You can also use SFC Service InSight to track parcels without a tracking code. SFC Service InSight is a value-added service shipping history that can provide eligible customers with a new level of visibility into shipment rates, delivery times, schedule, location and solutions.
Tracking number is code a uniquely generate by SFC Service courier service to track shipment status locations, times and condition of parcels. you can check tracking number online by using trackingnumber.net about your parcelsl status.
Go to the website of the SFC Service courier service or third party like trackingnumber.net you can check tracking number online, Scan or check the body of the SFC Service mail or receipt until you see a long code of string of numbers. Most tracking numbers are between 10 and 40 digits long close to the barcode and each one is uniquely generated Follow the instructions of your receipt, find for menu Track or Find. enter your tracking number and click track.
When your SFC Service parcels is in transit, it means the SFC Service Courier Services picked the parcels to nearest location and your SFC Service package in the process to the delivery address. The package status stays in transit until the SFC Service Courier driver delivers it to the receiver. if you want to know more about your parcels, you can use SFC Service parcels tracking to track the location and condition about your parcels.


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PRIVACY LOROORO.com ("LORO ORO") is totally committed to protecting the privacy of our site visitors and customers. The Loro Oro team members are customers themselves of other Internet sites and fully appreciate and respect the importance of privacy on the Internet. We will not disclose information about our customers to third parties except where it is part of providing a service to you - e.g. arranging for a product to be sent to you, carrying out credit and other security checks and for the purposes of customer research and profiling or where we have your express permission to do so.
We will not sell your name, address, e-mail address, credit card information or personal information to any third party (excluding partners from whom you may have linked to our site) without your permission.
If you have made a purchase from our store we may occasionally update you on our latest products, news and special offers via e-mail. You will also be given the opportunity to receive such communications from us and selected third parties when you become a member of LORO ORO. All LORO ORO members have the option to opt-out of receiving marketing communications from us and/or selected third parties. If you do not wish to continue to receive marketing from us and/or selected third parties you should opt-out by visiting 'Your Details' in 'Your Account' on the LORO ORO website. You can access 'Your Account' once you register and login. Or click on the "unsubscribe" link in any email communications which might we send you.
A cookie is a small information file that is sent to your computer and is stored on your hard drive. If you have registered with us then your computer will store an identifying cookie which will save you time each time you re-visit LORO ORO, by remembering your email address for you. You can change the settings on your browser to prevent cookies being stored on your computer without your explicit consent.
We may disclose aggregate, anonymized statistics about the number of visitors to this Website or number of purchases made as required by our investors. We use an independent measurement and research company to gather data regarding the visitors to this Website on our behalf using cookies and code which is embedded in the site. Both the cookies and the embedded code provide statistical information about visits to pages on the site, the duration of individual page view, paths taken by visitors through the site, data on visitors' screen settings and other general information. LORO ORO uses and stores this type of information, as with that obtained from other cookies used on the site, to help it improve the services to its users. Further information regarding the way in which this information is obtained and used can be obtained by contacting us at : firstname.lastname@example.com
We may use personal information provided by you in order to conduct appropriate anti-fraud checks. Personal information that you provide may be disclosed to a credit reference or fraud prevention agency, which may keep a record of that information. This is done only to confirm your identity - a credit check is not performed and your credit rating is unaffected.
The information that we collect from you may be transferred to, and stored at, a destination outside the European Economic Area ("EEA"). It may also be processed by staff operating outside the EEA who work for LORO ORO or one of our suppliers. Such processing may, for example, be required in order to fulfill your order, process your payment details or provide support services. Unfortunately, the transmission of information via the Internet is not completely secure. We will do our best to protect your personal data, but cannot guarantee the security of data transmitted to our site; any transmission is at your own risk. Once we have received your information, we will use strict procedures and security features to try to prevent unauthorized access.
We may disclose your personal information to any of our group of companies. We may also disclose your personal information to third parties: in the event that LORO ORO sells or buys any business or assets; if LORO ORO or substantially all of its assets are acquired by a third party, in which case personal data which we hold about our customers may be one of the transferred assets; or if we are under a duty to disclose or share your personal data in order to comply with any legal obligation, or in order to enforce or apply our terms of; or to protect the rights, property, or safety of LORO ORO, our customers, or others. This includes exchanging information with other companies and organizations for the purposes of fraud protection and credit risk reduction.
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If you wish to verify the details you have submitted to LORO ORO you may do so by contacting us via the e-mail address or address given below. Our security procedures mean that we may request proof of identity before we reveal information. This proof of identity will take the form of your e-mail address and password submitted upon registration. You must therefore keep this information safe as you will be responsible for any action which we take in response to a request from someone using your e-mail and password. We would strongly recommend that you do not use the browser's password memory function as that would permit other people using your terminal to access your personal information.
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A feeling of pride overwhelms me when we took charge as the Founder members of the Kas Pathar website. We hope to utilize my expertise and experience on this opportunity bestowed on me, to collaborate with the people of Kas Pathar.
Kas Pathar with its scenic beauty, its hospitable people, religious and cultural harmony, heritage, architecture, art and culture has already established itself has a popular tourist destination on both the national as well as the international arena, achieving an enviable brand status in the process. In recent years, the number of local and foreign visitors has reached record highs.We also look forward to your suggestions, co-operation and good wishes in preserving the natural beauty, peace and tranquility of this Valley of flower called Kas Pathar.


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