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of Health and Human Services
Participating Organizations
National Institutes of Health (NIH) (http://www.nih.gov)
Components of Participating Organizations
National Institute of Neurological Disorders and Stroke (NINDS) (http://www.ninds.nih.gov);
National Institute on Drug Abuse (NIDA) (www.nida.nih.gov)
National Institute on Alcohol Abuse and Alcoholism (NIAAA) (http://www.niaaa.nih.gov)
Title: Novel Lentiviral Models of HIV Neuropathogenesis (R21)
Announcement Type
This is a reissue of PAS-06-276.
Announcement (PA) Number: PAS-08-179
NOTICE: Applications submitted in response to this Funding Opportunity Announcement (FOA) for Federal assistance must be submitted electronically through Grants.gov (http://www.grants.gov) using the SF424 Research and Related (R&R) forms and the SF424 (R&R) Application Guide.
This FOA must be read in conjunction with the application guidelines included with this announcement in Grants.gov/Apply for Grants (hereafter called Grants.gov/Apply).
A registration process is necessary before submission and applicants are highly encouraged to start the process at least four (4) weeks prior to the grant submission date. See Section IV.
Catalog of Federal Domestic Assistance Number(s)
93.853; 93.279; 93.242; 93.273
Key Dates
Release/Posted Date: June 18, 2008
Opening Date: August 7, 2008 (Earliest date an application may be submitted to Grants.gov)
Letters of Intent Receipt Date(s): Not applicable
NOTE: On time submission requires that applications be successfully submitted to Grants.gov no later than 5:00 p.m. local time (of the applicant institution/organization).
Application Due Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm
AIDS Application Submission/Receipt Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#AIDS.
Peer Review Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
Council Review Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
Earliest Anticipated Start Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
Additional Information To Be Available Date (URL Activation Date): Not Applicable
Expiration Date: May 8, 2011
Due Dates for E.O.
Not Applicable
Overview Content
Executive Summary
Part I Overview Information
Part II Full Text of Announcement
Section I. Funding Opportunity Description
1. Research Objectives
Section II. Award Information
1. Mechanism of Support
2. Funds Available
Section III. Eligibility Information
1. Eligible Applicants
A. Eligible Institutions
B. Eligible Individuals
2. Cost Sharing or Matching
3. Other-Special Eligibility Criteria
Section IV. Application and Submission Information
1. Request Application Information
2. Content and Form of Application Submission
3. Submission Dates and Times
A. Submission, Review, and Anticipated Start Dates
1. Letter of Intent
B. Submitting an Application Electronically to the NIH
C. Application Processing
4. Intergovernmental Review
5. Funding Restrictions
6. Other Submission Requirements and Information
Section V. Application Review Information
1. Criteria
2. Review and Selection Process
A. Additional Review Criteria
B. Additional Review Considerations
C. Resource Sharing Plan(s)
3. Anticipated Announcement and Award Dates
Section VI. Award Administration Information
1. Award Notices
2. Administrative and National Policy Requirements
3. Reporting
Section VII. Agency Contacts
1. Scientific/Research Contact(s)
2. Peer Review Contact(s)
3. Financial/Grants Management Contact(s)
Section VIII. Other Information - Required Federal Citations
Part II - Full Text of Announcement
Section I. Funding Opportunity Description
1. Research Objectives
The purpose of this Funding Opportunity Announcement (FOA), issued as a program announcement with set aside funds (PAS), is to promote the development and/or refinement of animal or ex vivo models for research into the mechanisms underlying the neurological complications that are found associated with HIV-1 infection in humans. Ex vivo model systems may allow studying human cells in vitro and may strengthen the validity of findings from animals as well as provide relevance to humans. The ultimate goal of this initiative will be to develop or enhance lentiviral model systems for use in the discovery and development of therapeutics for the treatment of AIDS patients with and without a history of drug or alcohol use.
In the era of HAART, central and peripheral neurological complications associated with HIV/AIDS continue to increase in prevalence as patients live longer with the disease. Currently there are no specific treatments that alleviate these conditions, and their pathogenesis is not fully understood. Recent findings suggest that the early host response to acute HIV infection may determine the ultimate outcome of infection, but there have been no studies examining whether these responses affect the likelihood or severity of neurological impairment. Disease progression may be modified by host factors, aging, stress or exposure to drugs of abuse or other exogenous factors. Further research is needed to investigate the relationships between the host and its environment in order to understand individual differences in disease outcome.
The strict host range of HIV-1 infection has complicated the widespread use of animal or ex vivo models in translational research toward the development of therapies for treating AIDS. The mechanisms by which HIV and related lentiviruses cause neural dysfunction are not fully understood, nor are their possible interactions with drugs of abuse. Studies of post-mortem tissues, neuroimaging and analysis of cerebral spinal fluid from AIDS patients over the course of disease have shed some light on pathogenic mechanisms. Infected monocytes, T-cells, brain microglia and astrocytes are all considered key players leading to the ultimate death and loss of neurons observed in patients suffering from AIDS dementia. Inflammatory mechanisms, including the expression of specific chemokines, and specific viral gene products have also been implicated in neuropathogenesis. Several non-human lentiviruses have been studied for insight into the mechanisms by which viral infection leads to the loss of neural function. Visna and Feline Immunodeficiency Virus (FIV) cause encephalitis with demonstrable pathology in the central nervous systems of sheep and cats respectively. Simian Immunodeficiency Virus (SIV) infection in macaques can also lead to CNS complications, and using animals with depleted immune systems or infecting animals with specific strains of SIV has been shown recently to accelerate the development of SIV encephalitis. These advances make SIV, a close relative of HIV, an attractive model for study of the lentiviral disease process in the nervous system. However, these large animal studies have been limited by both the cost of the research and the availability of animals. Small animal models of lentiviral encephalitis have not been widely developed, although some murine retroviruses have been shown to have impact on the nervous systems of mice. The development of alternative biologically applicable 3 dimensional (3-D) human tissue culture models for the study of HIV-associated dementia is encouraged. Human cells grown in 3 dimensions may mimic in vivo tissue architecture and can be more readily manipulated than animal models allowing more studies with less cost.
The similarities between non-human lentiviral disease of the nervous system and the complications of HIV/AIDS provide an opportunity for the development of treatments for the neurological sequelae of HIV infection that have not been fully explored. Appropriate opportunities for investigation to be considered for support under this FOA include but are not limited to:
The R21 mechanism is intended to encourage new exploratory and developmental research projects. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.
Applications for R21 awards should describe projects distinct from those supported through the traditional R01 mechanism. For example, long-term projects, or projects designed to increase knowledge in a well-established area, will not be considered for R21 awards. Applications submitted under this mechanism should be exploratory and novel. These studies should break new ground or extend previous discoveries toward new directions or applications. Projects of limited cost or scope that use widely accepted approaches and methods within well established fields are better suited for the R03 small grant mechanism. Information on the R03 program can be found at https://grants.nih.gov/grants/funding/r03.htm.
See Section VIII, Other Information - Required Federal
Citations, for policies related to this
Section II. Award Information
1. Mechanism of Support
This FOA will use the NIH Exploratory/Developmental Research Grant (R21) award mechanism. The Project Director/Principal Investigator (PD/PI) will be solely responsible for planning, directing, and executing the proposed project.
This FOA uses Just-in-Time information concepts see SF424 (R&R) Application Guide). It also uses the modular as well as the non-modular budget formats (see the Modular Applications and Awards section of the NIH Grants Policy Statement. Specifically, if you are submitting an application with direct costs in each year of $250,000 or less (excluding consortium Facilities and Administrative [F&A] costs), use the PHS398 Modular Budget component provided in the SF424 (R&R) Application Package and SF424 (R&R) Application Guide (see specifically Section 3.4, Modular Budget Component, of the Application Guide). All foreign applicants must complete and submit budget requests using the Research & Related Budget component.
2. Funds Available
Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. Although the financial plans of the Institutes and Centers (ICs) provide support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.
The total project period for an application submitted in response to this funding opportunity may not exceed 2 years. Although the size of award may vary with the scope of research proposed, it is expected that applications will stay within the budgetary guidelines for an exploratory/developmental project; direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. Applicants may request direct costs in $25,000 modules, up to the total direct costs limitation of $275,000 for the combined two-year award period. NIH grants policies as described in the NOT-OD-05-004, November 2, 2004.
NINDS intends to commit a total of up to $1,500,000 in total costs over three years for payment of applications responsive to this FOA and the companion R01 FOA. NIDA and NIMH intend to contribute an additional $500,000 and $400,000 each year, respectively, to these FOAs. NIAAA is not setting aside any specific funds for these FOAs; funding determination will depend on the overall scientific merit of the applications and the availability of funds.
Section III. Eligibility Information
1. Eligible Applicants
1.A. Eligible Institutions
You may submit an application(s) if your institution/organization has any of the following characteristics:
The following organizations/institutions are eligible to apply:
1.B. Eligible Individuals
Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the PD/PI is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
More than one PD/PI (i.e., multiple PDs/PIs), may be designated on the application for projects that require a team science approach and therefore clearly do not fit the single-PD/PI model. Additional information on the implementation plans and policies and procedures to formally allow more than one PD/PI on individual research projects is available at https://grants.nih.gov/grants/multi_pi. All PDs/PIs must be registered in the NIH electronic Research Administration (eRA) Commons prior to the submission of the application (see http://era.nih.gov/ElectronicReceipt/preparing.htm for instructions).
The decision of whether to apply for a grant with a single PD/PI or multiple PDs/PIs grant is the responsibility of the investigators and applicant organizations and should be determined by the scientific goals of the project. Applications for grants with multiple PDs/PIs will require additional information, as outlined in the instructions below. When considering the multiple PD/PI option, please be aware that the structure and governance of the PD/PI leadership team as well as the knowledge, skills and experience of the individual PDs/PIs will be factored into the assessment of the overall scientific merit of the application. Multiple PDs/PIs on a project share the authority and responsibility for leading and directing the project, intellectually and logistically. Each PD/PI is responsible and accountable to the grantee organization, or, as appropriate, to a collaborating organization, for the proper conduct of the project or program, including the submission of required reports. For further information on multiple PDs/PIs, please see https://grants.nih.gov/grants/multi_pi.
Cost Sharing or Matching
This program does not require cost sharing as defined in the current NIH Grants Policy Statement.
3. Other-Special Eligibility Criteria
Exploratory/developmental grant support is for new projects only; competing renewal (formerly competing continuation) applications will not be accepted.
Applicants may submit a resubmission, but such application must include an Introduction addressing issues raised in the previous critique (Summary Statement).
Applicants may submit more than one application, provided that each application is scientifically distinct.
Section IV. Application and Submission Information
Appropriate registrations with Grants.gov and eRA Commons must be completed on or before the due date in order to successfully submit an application. Several of the steps of the registration process could take four weeks or more. Therefore, applicants should immediately check with their business official to determine whether their organization/institution is already registered with both Grants.gov and the Commons. All registrations must be complete by the submission deadline for the application to be considered ?on-time? (see 3.C.1 for more information about on-time submission).
To download a SF424 (R&R) Application Package and
SF424 (R&R) Application Guide for completing the SF424 (R&R) forms for
this FOA, use the Apply for Grant Electronically button in this FOA or link
to http://www.grants.gov/Apply/ and
follow the directions provided on that Web site.
A one-time registration is required for institutions/organizations at both:
PDs/PIs should work with their institutions/organizations to make sure they are registered in the NIH eRA Commons.
Several additional separate actions are required before an applicant can submit an electronic application, as follows:
1) Organizational/Institutional Registration in Grants.gov/Get Registered
2) Organizational/Institutional Registration in the eRA Commons
3) Project Director/Principal Investigator (PD/PI) Registration in the NIH eRA Commons: Refer to the NIH eRA Commons System (COM) Users Guide.
Both the PD(s)/PI(s) and AOR/SO need separate accounts in the NIH eRA Commons since both are authorized to view the application image.
Note that if a PD/PI is also an NIH peer-reviewer with an Individual DUNS and CCR registration, that particular DUNS number and CCR registration are for the individual reviewer only. These are different than any DUNS number and CCR registration used by an applicant organization. Individual DUNS and CCR registration should be used only for the purposes of personal reimbursement and should not be used on any grant applications submitted to the Federal Government.
Several of the steps of the registration process could take four weeks or more. Therefore, applicants should immediately check with their business official to determine whether their organization/institution is already registered in both Grants.gov and the Commons. The NIH will accept electronic applications only from organizations that have completed all necessary registrations.
Request Application Information
Applicants must download the SF424 (R&R) application forms and the SF424 (R&R) Application Guide for this FOA through Grants.gov/Apply.
Only the forms package directly attached to a specific FOA can be used. You
will not be able to use any other SF424 (R&R) forms (e.g., sample forms,
forms from another FOA), although some of the "Attachment" files may
be useable for more than one FOA.
For further assistance, contact GrantsInfo -- Telephone 301-710-0267, Email: firstname.lastname@example.com.
Telecommunications for the hearing impaired: TTY 301-451-5936.
2. Content and Form of Application Submission
Prepare all applications using the SF424 (R&R) application forms and in accordance with the SF424 (R&R) Application Guide for this FOA through Grants.gov/Apply.
The SF424 (R&R) Application Guide is critical to submitting a complete and accurate application to NIH. Some fields within the SF424 (R&R) application components, although not marked as mandatory, are required by NIH (e.g., the Credential log-in field of the Research & Related Senior/Key Person Profile component must contain the PD/PIs assigned eRA Commons User ID). Agency-specific instructions for such fields are clearly identified in the Application Guide. For additional information, see Frequently Asked Questions Application Guide, Electronic Submission of Grant Applications.
The SF424 (R&R) application is comprised of data arranged in separate components. Some components are required, others are optional. The forms package associated with this FOA in Grants.gov/APPLY includes all applicable components, required and optional. A completed application in response to this FOA will include the following components:
Required Components:
SF424 (R&R) (Cover component)
Research & Related Project/Performance Site Locations
Research & Related Other Project Information
Research & Related Senior/Key Person
PHS398 Cover Page Supplement
PHS398 Research Plan
PHS398 Checklist
PHS398 Modular Budget or Research & Related Budget, as appropriate (See Section IV.6., Special Instructions, regarding appropriate required budget component.)
Optional Components:
PHS398 Cover Letter File
Research & Related Subaward Budget Attachment(s) Form
Organizations (Non-domestic [non-U.S.] Entities)
NIH policies concerning grants to foreign (non-U.S.) organizations can be found in the NIH Grants Policy Statement at: https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm#_Toc54600260.
Applications from Foreign organizations must:
Proposed research should provide special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions in other countries that are not readily available in the United States (U.S.) or that augment existing U.S. resources.
Applications with Multiple PDs/PIs
When multiple PDs/PIs are proposed, NIH requires one PD/PI to be designated as the "Contact PI, who will be responsible for all communication between the PDs/PIs and the NIH, for assembling the application materials outlined below, and for coordinating progress reports for the project. The contact PD/PI must meet all eligibility requirements for PD/PI status in the same way as other PDs/PIs, but has no other special roles or responsibilities within the project team beyond those mentioned above.
Information for the Contact PD/PI should be entered in Item 13 of the SF424 (R&R) Cover component. All other PDs/PIs should be listed in the Research & Related Senior/Key Person component and assigned the project role of PD/PI. Please remember that all PDs/PIs must be registered in the eRA Commons prior to application submission. The Commons ID of each PD/PI must be included in the Credential field of the Research & Related Senior/Key Person component. Failure to include this data field will cause the application to be rejected.
All projects proposing Multiple PDs/PIs will be required to include a new section describing the leadership plan approach for the proposed project.
Multiple PD/PI Leadership Plan: For applications designating multiple PDs/PIs, a new section of the research plan, entitled Multiple PD/PI Leadership Plan, must be included. A rationale for choosing a multiple PD/PI approach should be described. The governance and organizational structure of the leadership team and the research project should be described, and should include communication plans, process for making decisions on scientific direction, and procedures for resolving conflicts. The roles and administrative, technical, and scientific responsibilities for the project or program should be delineated for the PDs/PIs and other collaborators.
If budget allocation is planned, the distribution of resources to specific components of the project or the individual PDs/PIs should be delineated in the Leadership Plan. In the event of an award, the requested allocations may be reflected in a footnote on the Notice of Award (NoA).
Applications Involving a Single Institution
When all PDs/PIs are within a single institution, follow the instructions contained in the SF424 (R&R) Application Guide.
Applications Involving Multiple Institutions
When multiple institutions are involved, one institution must be designated as the prime institution and funding for the other institution(s) must be requested via a subcontract to be administered by the prime institution. When submitting a detailed budget, the prime institution should submit its budget using the Research & Related Budget component. All other institutions should have their individual budgets attached separately to the Research & Related Subaward Budget Attachment(s) Form. See Section 4.8 of the SF424 (R&R) Application Guide for further instruction regarding the use of the subaward budget form.
When submitting a modular budget, the prime institution completes the PHS398 Modular Budget component only. Information concerning the consortium/subcontract budget is provided in the budget justification. Separate budgets for each consortium/subcontract grantee are not required when using the Modular budget format. See Section 3.4 of the Application Guide for further instruction regarding the use of the PHS398 Modular Budget component.
3. Submission
Dates and Times
See Section IV.3.A. for details.
3.A. Submission, Review, and Anticipated Start Dates
Opening Date: August 7, 2008 (Earliest date an application may be submitted to Grants.gov).
Letters of Intent Receipt Date(s): Not applicable
Application Due Date(s): Standard dates apply, please see https://grants.nih.gov/grants/funding/submissionschedule.htm
AIDS Application Submission/Receipt Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#AIDS
Peer Review Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
Council Review Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
Earliest Anticipated Start Date(s): Standard dates apply, please see http://grants1.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
3.A.1. Letter of Intent
A letter of intent is not required for the funding opportunity.
3.B. Submitting an Application Electronically to the
To submit an application in response to this FOA, applicants should access this FOA via http://www.grants.gov/web/grants/applicants/apply-for-grants.html and follow steps 1-4. Note: Applications must only be submitted electronically. PAPER APPLICATIONS WILL NOT BE ACCEPTED.
Application Processing
Applications may be submitted on or after the opening date and must be successfully received by Grants.gov no later than 5:00 p.m. local time(of the applicant institution/organization) on the application due date(s). (See Section IV.3.A. for all dates.) If an application is not submitted by the due date(s) and time, the application may be delayed in the review process or not reviewed. All applications must meet the following criteria to be considered on-time:
Please visit http://era.nih.gov/electronicReceipt/app_help.htm for detailed information on what to do if Grants.gov or eRA system issues threaten your ability to submit on time.
Submission to Grants.gov is not the last step - applicants must follow their application through to the eRA Commons to check for errors and warnings and view their assembled application!
3.C.2 Two Day Window to Correct eRA Identified Errors/Warnings
IMPORTANT NOTE! NIH has eliminated the error correction window for due dates of January 25, 2011 and beyond. As of January 25, all corrections must be complete by the due date for an application to be considered on-time. See NOT-OD-10-123.
Once an application package has been successfully submitted through Grants.gov NIH provides applicants a two day error correction window to correct any eRA identified errors or warnings before a final assembled application is created in the eRA Commons. The standard error correction window is two (2) business days, beginning the day after the submission deadline and excluding weekends and standard federal holidays. All errors must be corrected to successfully complete the submission process. Warnings will not prevent the application from completing the submission process.
Note that the following caveats apply:
3.C.3 Viewing an Application in the eRA Commons
Once any eRA identified errors have been addressed and the assembled application has been created in the eRA Commons, the PD/PI and the Authorized Organization Representative/Signing Official (AOR/SO) have two weekdays (Monday Friday, excluding Federal holidays) to view the assembled application before it automatically moves forward to NIH for further processing.
receipt, applications will be evaluated for completeness by the Center for
Scientific Review, NIH. Incomplete applications will not be reviewed.
There will be an acknowledgement of receipt of applications from Grants.gov and the Commons. The submitting AOR/SO receives the Grants.gov acknowledgments. The AOR/SO and the PI receive Commons acknowledgments. Information related to the assignment of an application to a Scientific Review Group is also in the Commons.
Note: Since email can be unreliable, it is the responsibility of the applicant to check periodically on their application status in the Commons.
The NIH will not accept any application in response to this FOA that is essentially the same as one currently pending initial merit review unless the applicant withdraws the pending application. The NIH will not accept any application that is essentially the same as one already reviewed. However, the NIH will accept a resubmission application, but such application must include an Introduction addressing the critique from the previous review.
4. Intergovernmental Review
This initiative is not subject to intergovernmental review.
5. Funding Restrictions
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
costs are allowable. A grantee may, at its own risk and without NIH prior
approval, incur obligations and expenditures to cover costs up to 90 days
before the beginning date of the initial budget period of a new or competing
renewal award if such costs: 1) are necessary to conduct the project, and 2)
would be allowable under the grant, if awarded, without NIH prior approval. If
specific expenditures would otherwise require prior approval, the grantee must
obtain NIH approval before incurring the cost. NIH prior approval is required
for any costs to be incurred more than 90 days before the beginning date of the
initial budget period of a new or competing renewal award.
The incurrence of pre-award costs in anticipation of a competing or non-competing award imposes no obligation on NIH either to make the award or to increase the amount of the approved budget if an award is made for less than the amount anticipated and is inadequate to cover the pre-award costs incurred. NIH expects the grantee to be fully aware that pre-award costs result in borrowing against future support and that such borrowing must not impair the grantee's ability to accomplish the project objectives in the approved time frame or in any way adversely affect the conduct of the project. See NIH Grants Policy Statement https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm.
6. Other Submission
Requirements and Information
PD/PI Credential (e.g., Agency Login)
The NIH requires the PD(s)/PI(s) to fill in his/her Commons User ID in the PROFILE Project Director/Principal Investigator section, Credential log-in field of the Research & Related Senior/Key Person Profile component.
Organizational DUNS
The applicant organization must include its DUNS number in its Organization Profile in the eRA Commons. This DUNS number must match the DUNS number provided at CCR registration with Grants.gov. For additional information, see Frequently Asked Questions Application Guide, Electronic Submission of Grant Applications.
PHS398 Research Plan Component Sections
While each section of the Research Plan needs to be uploaded separately as a PDF attachment, applicants are encouraged to construct the Research Plan component as a single document, separating sections into distinct PDF attachments just before uploading the files. This approach will enable applicants to better monitor formatting requirements such as page limits. All attachments must be provided to NIH in PDF format, filenames must be included with no spaces or special characters, and a .pdf extension must be used.
All application instructions outlined in the SF424 (R&R) Application Guide are to be followed, incorporating "Just-in-Time" information concepts, and with the following requirements for R21 applications:
Appendix Materials
Applicants must follow the specific instructions on Appendix materials as described in the SF424 (R&R) Application Guide (See https://grants.nih.gov/grants/funding/424/index.htm). Also see https://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-018.html.
Do not use the Appendix to circumvent the page limitations. An application that does not comply with the required page limitations may be delayed in the review process.
Resource Sharing Plan(s)
NIH considers the sharing of unique research resources developed through NIH-sponsored research an important means to enhance the value and further the advancement of the research. When resources have been developed with NIH funds and the associated research findings published or provided to NIH, it is important that they be made readily available for research purposes to qualified individuals within the scientific community. If the final data/resources are not amenable to sharing, this must be explained in the Resource Sharing section of the application (see https://grants.nih.gov/grants/policy/data_sharing/data_sharing_faqs.htm.)
(a) Data Sharing Plan: Regardless of the amount requested, investigators are expected to include a brief 1-paragraph description of how final research data will be shared, or explain why data-sharing is not possible. Applicants are encouraged to discuss data-sharing plans with their NIH program contact (see Data-Sharing Policy or https://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-032.html.)
(b) Sharing Model Organisms: Regardless of the amount requested, all applications where the development of model organisms is anticipated are expected to include a description of a specific plan for sharing and distributing unique model organisms and related resources or state appropriate reasons why such sharing is restricted or not possible (see Sharing Model Organisms Policy, and NOT-OD-04-042.)
(c) Genome-Wide Association Studies (GWAS): Regardless of the amount requested, applicants seeking funding for a genome-wide association study are expected to provide a plan for submission of GWAS data to the NIH-designated GWAS data repository, or provide an appropriate explanation why submission to the repository is not possible. A genome-wide association study is defined as any study of genetic variation across the entire genome that is designed to identify genetic associations with observable traits (e.g., blood pressure or weight) or the presence or absence of a disease or condition. For further information see Policy for Sharing of Data Obtained in NIH Supported or Conducted Genome-Wide Association Studies (go to NOT-OD-07-088, and https://grants.nih.gov/grants/gwas/.)
The adequacy of the resources sharing plan and any related data sharing plans will be considered by Program staff of the funding organization when making recommendations about funding applications. The effectiveness of the resource sharing will be evaluated as part of the administrative review of each Non-Competing Grant Progress Report (PHS 2590). See Section VI.3., Reporting.
Foreign Applications (Non-domestic (non-U.S.) Entity)
Indicate how the proposed project has specific relevance to the mission and objectives of the NIH/IC and has the potential for significantly advancing the health sciences in the United States.
Section V. Application Review Information
1. Criteria (Update: Enhanced review criteria have been issued for the evaluation of research applications received for potential FY2010 funding and thereafter - see NOT-OD-09-025).
Only the review criteria described below will be considered in the review process.
Review and Selection Process
Applications submitted for this funding opportunity will be assigned to the ICs on the basis of established Public Health Service (PHS) referral guidelines.
Applications that are complete will be evaluated for scientific and technical merit by (an) appropriate scientific review group(s) in accordance with NIH peer review procedures (http://grants1.nih.gov/grants/peer/) using the review criteria stated below.
As part of the initial merit review, all applications will:
Applications submitted in response to this funding opportunity will compete for available funds with all other recommended applications. The following will be considered in making funding decisions:
The NIH R21 exploratory/developmental grant is a mechanism for supporting novel scientific ideas or new model systems, tools, or technologies that have the potential to significantly advance our knowledge or the status of health-related research.
Because the Research Strategy is limited to 6 pages, an exploratory/developmental grant application need not have extensive background material or preliminary information as one might normally expect in an R01 application. Accordingly, reviewers will focus their evaluation on the conceptual framework, the level of innovation, and the potential to significantly advance our knowledge or understanding. Reviewers will place less emphasis on methodological details and certain indicators traditionally used in evaluating the scientific merit of R01 applications, including supportive preliminary data. Appropriate justification for the proposed work can be provided through literature citations, data from other sources, or, when available, from investigator-generated data. Preliminary data are not required for R21 applications; however, they may be included if available.
The mission of the NIH is to support science in pursuit of knowledge about the biology and behavior of living systems and to apply that knowledge to extend healthy life and reduce the burdens of illness and disability. As part of this mission, applications submitted to the NIH for grants or cooperative agreements to support biomedical and behavioral research are evaluated for scientific and technical merit through the NIH peer review system.
Overall Impact. Reviewers will provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following five core review criteria, and additional review criteria (as applicable for the project proposed).
Core Review Criteria. Reviewers will consider each of the five review criteria below in the determination of scientific and technical merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.
Significance: Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
Investigator(s): Are the PD/PIs, collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?
Innovation: Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?
Approach: Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project? Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed?
If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed? for applications designating multiple PDs/ PIs, is the leadership approach, including the designated roles and responsibilities. governance, and organizational structure, consistent with and justified by the aims of the project and the expertise of each of the PDs/PIs?
Environment: Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?
Additional Review Criteria
As applicable for the project proposed, reviewers will consider the following additional items in the determination of scientific and technical merit, but will not give separate scores for these items.
Protections for Human Subjects. For research that involves human subjects but does not involve one of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate the justification for involvement of human subjects and the proposed protections from research risk relating to their participation according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained, and 5) data and safety monitoring for clinical trials.
For research that involves human subjects and meets the criteria for one or more of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials.
Inclusion of Women, Minorities, and Children. When the proposed project involves clinical research, the committee will evaluate the proposed plans for inclusion of minorities and members of both genders, as well as the inclusion of children.
Vertebrate Animals. The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following five points: 1) proposed use of the animals, and species, strains, ages, sex, and numbers to be used; 2) justifications for the use of animals and for the appropriateness of the species and numbers proposed; 3) adequacy of veterinary care; 4) procedures for limiting discomfort, distress, pain and injury to that which is unavoidable in the conduct of scientifically sound research including the use of analgesic, anesthetic, and tranquilizing drugs and/or comfortable restraining devices; and 5) methods of euthanasia and reason for selection if not consistent with the AVMA Guidelines on Euthanasia.
Resubmission Applications. When reviewing a Resubmission application (formerly called an amended application), the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project.
Renewal Applications. When reviewing a Renewal application (formerly called a competing continuation application), the committee will consider the progress made in the last funding period.
Revision Applications. When reviewing a Revision application (formerly called a competing supplement application), the committee will consider the appropriateness of the proposed expansion of the scope of the project. If the Revision application relates to a specific line of investigation presented in the original application that was not recommended for approval by the committee, then the committee will consider whether the responses to comments from the previous scientific review group are adequate and whether substantial changes are clearly evident.
Biohazards. Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.
Additional Review Considerations
As applicable for the project proposed, reviewers will address each of the following items, but will not give scores for these items and should not consider them in providing an overall impact score.
Budget and Period Support. Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.
Select Agents Research. Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).
Applications from Foreign Organizations. Reviewers will assess whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions that exist in other countries and either are not readily available in the United States or augment existing U.S. resources.
Resource Sharing Plans. Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not sharing the following types of resources, are reasonable: 1) Data Sharing Plan (https://grants.nih.gov/grants/policy/data_sharing/data_sharing_guidance.htm); 2) Sharing Model Organisms (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-04-042.html); and 3) Genome Wide Association Studies (GWAS) (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-088.html).
Anticipated Announcement and Award Dates
Not Applicable
Section VI. Award Administration Information
Award Notices
After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the NIH eRA Commons.
the application is under consideration for funding, NIH will request
"just-in-time" information from the applicant. For details,
applicants may refer to the NIH
Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards,
Subpart A: General.
A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization. The NoA signed by the grants management officer is the authorizing document. Once all administrative and programmatic issues have been resolved, the NoA will be generated via email notification from the awarding component to the grantee business official.
Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs. See Section IV.5., Funding Restrictions.
2. Administrative and National Policy Requirements
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities.
When multiple years are involved, awardees will be required to submit the Non-Competing Continuation Grant Progress Report (PHS 2590) annually and financial statements as required in the NIH Grants Policy Statement.
A final progress report, invention statement, and Financial Status Report are required when an award is relinquished when a recipient changes institutions or when an award is terminated.
Section VII. Agency Contacts
We encourage your inquiries concerning this funding
opportunity and welcome the opportunity to answer questions from potential
applicants. Inquiries may fall into three areas: scientific/research, peer
review, and financial or grants management issues:
1. Scientific/Research Contacts:
May Wong, Ph.D.
Program Director
NSC, Room 2113
6001 Executive Blvd.
Bethesda, MD 20892-9521
FEDEX or courier shipments use: Rockville, MD 20852
Phone: (301) 496-1431
E-mail: email@example.com
Diane Lawrence, Ph.D.
Health Scientist Administrator
Division of Basic Neuroscience and Behaviroral Research
National Institute on Drug Abuse
6001 Executive Blvd., Room 4292
Bethesda, MD 20892-9555
Phone: (301) 443-6975
Fax: (301) 5944-6043
E-mail: email@example.com
Jeymohan Joseph, Ph.D.
Division of AIDS and Health and Behavior Research
National Institute of Mental Health
6001 Executive Boulevard, Room 6202, MSC 9619
Bethesda, MD 20892-9619
Telephone: (301) 443-3012
Email: firstname.lastname@example.com
John A. Matochik, Ph.D.
Division of Neuroscience and Behavior
National Institute on Alcohol Abuse and Alcoholism
5635 Fishers Lane
Room 2048, MSC 9304
Bethesda, MD 20892-9304
(overnight or express mail, use: Rockville, MD 20852-1705)
Telephone: (301) 451-7319
Email: email@example.com
2. Peer Review Contacts:
Not Applicable
3. Financial or Grants
Management Contacts:
Ms. Tijuanna DeCoster, MPA
National Institute of Neurological Disorders and Stroke
Grants Management Officer
Division of Extramural Research
Neuroscience Center
6001 Executive Blvd., Room 3258
Bethesda, MD 20892
Telephone: 301-496-9531
Fax: 301-402-0219
Email: firstname.lastname@example.com
Gary Fleming, J.D.
Chief, Grants Management Branch/OPRM
National Institute on Drug Abuse/NIH/DHHS
6101 Executive Blvd, Room 270
Bethesda, MD 20892
Telephone: (301) 443-6710
Email: email@example.com
Rita Sisco
Division of Extramural Activities
National Institute of Mental Health
6001 Executive Boulevard, Room 6115, MSC 9605
Bethesda, MD 20892-9605
Telephone: (301) 443-2805
Email: firstname.lastname@example.com
Ms. Judy Fox, Chief
Grants Management Branch
National Institute on Alcohol Abuse and Alcoholism
5635 Fishers Lane, Room 3023
Bethesda, MD 20892-9304
Phone: 301-443-4704
Fax: 301-443-3891
Email: email@example.com
Section VIII. Other Information
Required Federal Citations
Vertebrate Animals:
Recipients of PHS support for activities involving live, vertebrate animals must comply with PHS Policy on Humane Care and Use of Laboratory Animals (https://grants.nih.gov/grants/olaw/references/PHSPolicyLabAnimals.pdf) as mandated by the Health Research Extension Act of 1985 (https://grants.nih.gov/grants/olaw/references/hrea1985.htm), and the USDA Animal Welfare Regulations (http://www.nal.usda.gov/awic/legislat/usdaleg1.htm) as applicable.
Human Subjects Protection:
Federal regulations (45 CFR 46) require that applications and proposals involving human subjects must be evaluated with reference to the risks to the subjects, the adequacy of protection against these risks, the potential benefits of the research to the subjects and others, and the importance of the knowledge gained or to be gained (http://www.hhs.gov/ohrp/humansubjects/guidance/45cfr46.htm).
Data and Safety Monitoring Plan:
Data and safety monitoring is required for all types of clinical trials, including physiologic toxicity and dose-finding studies (Phase I); efficacy studies (Phase II); efficacy, effectiveness and comparative trials (Phase III). Monitoring should be commensurate with risk. The establishment of data and safety monitoring boards (DSMBs) is required for multi-site clinical trials involving interventions that entail potential risks to the participants (NIH Policy for Data and Safety Monitoring, NIH Guide for Grants and Contracts, https://grants.nih.gov/grants/guide/notice-files/not98-084.html).
Sharing Research Data:
Investigators submitting an NIH application seeking $500,000 or more in direct costs in any single year are expected to include a plan for data sharing or state why this is not possible (https://grants.nih.gov/grants/policy/data_sharing).
Investigators should seek guidance from their institutions, on issues related to institutional policies and local IRB rules, as well as local, State and Federal laws and regulations, including the Privacy Rule. Reviewers will consider the data sharing plan but will not factor the plan into the determination of the scientific merit or the impact/priority score.
Policy for Genome-Wide
Association Studies (GWAS):
NIH is interested in advancing genome-wide association studies (GWAS) to identify common genetic factors that influence health and disease through a centralized GWAS data repository. For the purposes of this policy, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. All applications, regardless of the amount requested, proposing a genome-wide association study are expected to provide a plan for submission of GWAS data to the NIH-designated GWAS data repository, or provide an appropriate explanation why submission to the repository is not possible. Data repository management (submission and access) is governed by the Policy for Sharing of Data Obtained in NIH Supported or Conducted Genome-Wide Association Studies, NIH Guide NOT-OD-07-088. For additional information, see https://grants.nih.gov/grants/gwas/.
Sharing of Model Organisms:
NIH is committed to support efforts that encourage sharing of important research resources including the sharing of model organisms for biomedical research (see https://grants.nih.gov/grants/policy/model_organism/index.htm). At the same time the NIH recognizes the rights of grantees and contractors to elect and retain title to subject inventions developed with Federal funding pursuant to the Bayh-Dole Act (see the NIH Grants Policy Statement. Beginning October 1, 2004, all investigators submitting an NIH application or contract proposal are expected to include in the application/proposal a description of a specific plan for sharing and distributing unique model organism research resources generated using NIH funding or state why such sharing is restricted or not possible. This will permit other researchers to benefit from the resources developed with public funding. The inclusion of a model organism sharing plan is not subject to a cost threshold in any year and is expected to be included in all applications where the development of model organisms is anticipated.
Access to Research Data through the Freedom of
Information Act:
The Office of Management and Budget (OMB) Circular A-110 has been revised to provide access to research data through the Freedom of Information Act (FOIA) under some circumstances. Data that are (1) first produced in a project that is supported in whole or in part with Federal funds and (2) cited publicly and officially by a Federal agency in support of an action that has the force and effect of law (i.e., a regulation) may be accessed through FOIA. It is important for applicants to understand the basic scope of this amendment. NIH has provided guidance at https://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm. Applicants may wish to place data collected under this funding opportunity in a public archive, which can provide protections for the data and manage the distribution for an indefinite period of time. If so, the application should include a description of the archiving plan in the study design and include information about this in the budget justification section of the application. In addition, applicants should think about how to structure informed consent statements and other human subjects procedures given the potential for wider use of data collected under this award.
Inclusion of Women, Minorities, and Children:
It is the policy of the NIH that women and members of minority groups and their sub-populations must be included in all NIH-supported clinical research projects unless a clear and compelling justification is provided indicating that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing clinical research should read the "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-001.html); a complete copy of the updated Guidelines is available at https://grants.nih.gov/grants/funding/women_min/guidelines_amended_10_2001.htm. The amended policy incorporates: the use of an NIH definition of clinical research; updated racial and ethnic categories in compliance with the new OMB standards; clarification of language governing NIH-defined Phase III clinical trials consistent with the SF424 (R&R) application; and updated roles and responsibilities of NIH staff and the extramural community. The policy continues to require for all NIH-defined Phase III clinical trials that: a) all applications or proposals and/or protocols must provide a description of plans to conduct analyses, as appropriate, to address differences by sex/gender and/or racial/ethnic groups, including subgroups if applicable; and b) investigators must report annual accrual and progress in conducting analyses, as appropriate, by sex/gender and/or racial/ethnic group differences.
Inclusion of Children as Participants in Clinical Research:
The NIH maintains a policy that children (i.e., individuals under the age of 21) must be included in all clinical research, conducted or supported by the NIH, unless there are scientific and ethical reasons not to include them.
All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines" on the inclusion of children as participants in research involving human subjects (https://grants.nih.gov/grants/funding/children/children.htm).
Required Education on the Protection of Human Subject Participants:
NIH policy requires education on the protection of human subject participants for all investigators submitting NIH applications for research involving human subjects and individuals designated as key personnel. The policy is available at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html.
Human Embryonic Stem Cells (hESC):
Criteria for federal funding of research on hESCs can be found at http://stemcells.nih.gov/index.asp and at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-116.html. Only research using hESC lines that are registered in the NIH Human Embryonic Stem Cell Registry will be eligible for Federal funding (http://escr.nih.gov/). It is the responsibility of the applicant to provide in the project description and elsewhere in the application as appropriate, the official NIH identifier(s) for the hESC line(s) to be used in the proposed research.
NIH Public Access Policy Requirement:
In accordance with the NIH Public Access Policy, investigators funded by the NIH must submit or have submitted for them to the National Library of Medicines PubMed Central (see http://www.pubmedcentral.nih.gov/), an electronic version of their final, peer-reviewed manuscripts upon acceptance for publication, to be made publicly available no later than 12 months after the official date of publication. The NIH Public Access Policy is available at (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-08-033.html). For more information, see the Public Access webpage at http://publicaccess.nih.gov/.
for Privacy of Individually Identifiable Health Information:
The Department of Health and Human Services (HHS) issued final modification to the "Standards for Privacy of Individually Identifiable Health Information", the "Privacy Rule", on August 14, 2002. The Privacy Rule is a federal regulation under the Health Insurance Portability and Accountability Act (HIPAA) of 1996 that governs the protection of individually identifiable health information, and is administered and enforced by the HHS Office for Civil Rights (OCR).
Decisions about applicability and implementation of the Privacy Rule reside with the researcher and his/her institution. The OCR website (http://www.hhs.gov/ocr/) provides information on the Privacy Rule, including a complete Regulation Text and a set of decision tools on "Am I a covered entity?" Information on the impact of the HIPAA Privacy Rule on NIH processes involving the review, funding, and progress monitoring of grants, cooperative agreements, and research contracts can be found at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-025.html.
URLs in NIH Grant Applications or Appendices:
All applications and proposals for NIH funding must be self-contained within specified page limitations. For publications listed in the appendix and/or Progress report, Internet addresses (URLs) or PubMed Central (PMC) submission identification numbers must be used for publicly accessible on-line journal articles. Publicly accessible on-line journal articles or PMC articles/manuscripts accepted for publication that are directly relevant to the project may be included only as URLs or PMC submission identification numbers accompanying the full reference in either the Bibliography & References Cited section, the Progress Report Publication List section, or the Biographical Sketch section of the NIH grant application. A URL or PMC submission identification number citation may be repeated in each of these sections as appropriate. There is no limit to the number of URLs or PMC submission identification numbers that can be cited.
People 2010:
The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS-led national activity for setting priority areas. This FOA is related to one or more of the priority areas. Potential applicants may obtain a copy of "Healthy People 2010" at http://www.health.gov/healthypeople.
Authority and Regulations:
This program is described in the Catalog of Federal Domestic Assistance at http://www.cfda.gov/ and is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Parts 74 and 92. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
The PHS strongly encourages all grant recipients to provide a smoke-free workplace and discourage the use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
Loan Repayment Programs:
NIH encourages applications for educational loan repayment from qualified health professionals who have made a commitment to pursue a research career involving clinical, pediatric, contraception, infertility, and health disparities related areas. The LRP is an important component of NIH's efforts to recruit and retain the next generation of researchers by providing the means for developing a research career unfettered by the burden of student loan debt. Note that an NIH grant is not required for eligibility and concurrent career award and LRP applications are encouraged. The periods of career award and LRP award may overlap providing the LRP recipient with the required commitment of time and effort, as LRP awardees must commit at least 50% of their time (at least 20 hours per week based on a 40 hour week) for two years to the research. For further information, please see: http://www.lrp.nih.gov/.
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
Office of Extramural
Research (OER)
National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
Department of Health
and Human Services (HHS)
Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.


text:
Last fall LACMA held its first annual Art + Film Gala, honoring Clint Eastwood and John Baldessari. For those who were there, one of the big highlights of the night turned out to be a short film about Baldessari (narrated by Tom Waits!), made by filmmakers Henry Joost and Ariel Schulman, aka Supermarché. Just yesterday we received the green light to share it with you. So, here you go: everything you ever wanted to know about John Baldessari, including his wi-fi password. Enjoy!
Scott Tennent

subset: commoncrawl


text:
The file you are trying to view (Orion Destiny - Orion_Destiny.rar) uploaded by Aethersoft has been deleted and is no longer available. This may have occurred at the uploaders request, or it may have occurred because it violated the sites Terms of Use. If this is a mistake and you are the uploader of this file and would like it re-activated, please contact us with the details.
We recommend you return to the download list and browse the links from there.


text:
Hints for mangler in main
mangler.desktop ⚙ amd64
This software component is missing a MetaInfo file to provide metadata.
We currently took some data from its desktop-entry file and the long description of the package it is located in.
This has several disadvantages, like poor markup, too technical descriptions for users of software centers, different components having the same description, etc.
Additionally, a lot of software with desktop-entry files should either not be installable and searchable via the software catalog (like desktop-specific settings applications) or be tagged accordingly via MetaInfo files.
Please consider to either hide this desktop-entry file from AppStream by adding a
X-AppStream-Ignore=truefield to it, or to write a MetaInfo file for this component and send it upstream.
Generating components from non-MetaInfo files is deprecated, if you do not add a MetaInfo file, this software may vanish from the metadata catalog (and if it is a GUI application, no longer be visible in software centers) in a future distribution release.
You can consult the MetaInfo quickstart guides for more information on how to write a MetaInfo file, or file a bug with the upstream author of this software component.


text:
ITAT Recruitment 2022 For Senior Private Secretary – application form, apply online total 34 vacancies / 7 March 2022 last date for job apply and post notification available on itat.gov.in
Job opportunity by the department of ITAT for the post of Senior Private Secretary and the number of vacancies is 34. Let's know everything about the notification of ITAT Recruitment 2022.
A notification has been published by ITAT for the post of Senior Private Secretary in daily newspapers, employment news and on its official website. You can know all details of ITAT recruitment/vacancy through any one of these sources.
This notification of ITAT will provide you complete process of the Senior Private Secretary recruitment viz how to apply, age limit, educational criteria, examination fee and its date etc. Also read – Baroda UP Bank Recruitment 2022 for Apprentices – Apply Online
ITAT Recruitment 2022 in brief
Department/Organizer – ITAT
Designation of vacancy – Senior Private Secretary
Vacancies – 34
Age Limit – max 56 and According to policy
Reservation – According to policy
Important Dates of ITAT
Last Date/Apply upto – 7 March 2022
Useful Links for ITAT Recruitment 2022
Here is the link of official website of ITAT for downloading notification of the vacancy –
Official website – itat.gov.in
How to apply for ITAT Vacancy/recruitment
- Go to official webpage of ITAT to download the notification for Senior Private Secretary.
- Get the print of downloaded file of the ITAT notification.
- You can also get this notification from Daily News Papers, Employment News etc.
- After getting copy of ITAT vacancy 2022 notification you will get everything about the process of the recruitment of the Senior Private Secretary.
- Follow all the important dates and process of different steps to apply for the vacancy.
Different types of process followed by recruitment agencies:-
Although most of the job recruitment agencies follow online process but sometime offline and direct recruitment is also adopted.
Online method – In this process all the important steps are done online through the official website of the job provider.
Offline method – It includes manual filling of the prescribed application form by the applicant and then send it with required documents to the given official address. Final selection in online and offline method is based on marks obtained by the applicant in exam/interview performed by the concern department.
Direct recruitment – There is no exam in this type of vacancy. The marks obtained by the candidates in secondary board/graduate or post graduate degree etc. is the main base of recruitment.
Conclusion of the process
After filling the form and depositing required fee as per norms download acknowledgement as the proof of the candidateship for the vacancy of ITAT Recruitment 2022.
So guys best of luck to all of you. Have your regular visit to our job dedicated website for regular updates of all important job opportunities.


text:
When someone visits our website we collect standard internet log information and details of visitor behaviour patterns. We do this to find out things such as the number of visitors to the various parts of the site. We collect this information in a way which does not identify anyone. We do not make any attempt to find out the identities of those visiting our website. We will not associate any data gathered from this site with any personally identifying information from any source. If we do want to collect personally identifiable information through our website, such as our online contact form, we will be clear about this.
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Cookies are small text files that are placed on your computer by websites that you visit. They are widely used in order to make websites work, or work more efficiently, as well as to provide information to the owners of the site.
The table below explains the cookies we use and why.
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These cookies are used to collect information about how visitors use our site. We use the information to help us improve the site. The cookies collect information in an anonymous form, including the number of visitors to the site, where visitors have come to the site from and the pages they visited.
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To opt out of being tracked by Google Analytics visit https://tools.google.com/dlpage/gaoptout.


text:
PhD defence
Therapeutic targeting of immune-escaped cancers
- K.A. Marijt
- Date
- Tuesday 18 February 2020
- Time
- Location
Academy Building
Rapenburg 73
2311 GJ Leiden
- Prof. S. van der Burg
PhD defences are free; you do not have to register.
PhD dissertations
PhD dissertations by Leiden PhD students are available digitally after the defence through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.
Press contact


text:
Ju-Ju-Be Be Classy - The NavigatorRegular price $65.00 Sale price $38.99
Shipping calculated at checkout.
This is what happens when a company listens to you. There is no perfect bag...they can always get better. We make them better by listening to the people that use them the most. We've received thousands of comments from our customers on how to improve our bags and have used that input to create the next innovation in the Ju-Ju-Be line ... the Be Classy. We listened when you asked for a bag that's smaller than the Be Prepared and without the flap of a Better Be. We complied with the request for sleek internal bottle pockets like the BeHave. We wholeheartedly agreed with the comment that it should have clean external lines and an upscale silhouette. We followed the directive to put structured hand-bag style handles for shoulder carrying but also include a messenger strap as well. We thank you for your input. We are proud to introduce the Be Classy....and you should be too.
- Structured tote with luggage feet
- Front mommy pocket holds keys (stretch key fob) and sunglasses (cleans lenses too!) with plenty of room for more!
- Memory foam changing pad included ... nice 'n comfy, super cushy.
- Quick reach pocket for cell phone.
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- Tour your community and list the different building types you see. Try to identify buildings that can be associated with a specific period of history or style of architecture. Make a sketch of the building you most admire.
- Select a historical architectural achievement that has had a major impact on society. Using resources such as the Internet (with your parent's permission), books, and magazines, find out how this achievement has influenced the world today. Tell your counselor what you learned.
- In the Outdoor Code, a Scout pledges to "be conservation-minded."
Discuss the following with your counselor:
- The term sustainable architecture. Identify three features typical of green buildings.
- The difference between renewable building materials and recycled building materials, and how each can be used in construction.
- The relationship of architecture with its surrounding environment and the community.
- How entire buildings can be reused rather than torn down when they no longer serve their original purpose.
- Do ONE of the following:
- With your parent's and counselor's permission and approval, arrange to meet with an architect. Ask to see the scale model of a building and the drawings that a builder would use to construct this building. Discuss why the different building materials were selected. Look at the details in the drawings and the scale model to see how the materials and components are attached to each other during construction.
- With your parent's and counselor's permission and approval,
arrange to meet with an architect at a construction site. Ask the
architect to bring drawings that the builder uses to construct the
building. While at the site, discuss why the different building
materials being used were selected. Discuss how the different building
materials and components are attached to each other during construction.
Note: To visit a construction site will require advance planning. You will need permission from your parents, counselor, the architect, and the construction site manager. A construction site is a very dangerous place. While there, you will need to closely follow the site manager's directions and comply with all the safety procedures, including wearing a hard hat protective eyewear, and proper footwear. Be aware of the changing conditions at the site, and stay with the architect or site manager.
- Interview someone who might be your client (such as a prospective homeowner or business owner) if you were an architect. Find out what your client's requirements would be for designing a new home or business building. Write a short program including a list of requirements for the project, the functions of the building and site, hoe the functions relate to one another, and the goals of the project.
- Measure a room such as one where you live or where your troop meets. Make an accurately scaled drawing of the room's floor plan showing walls, doors, closets, windows, and any built-in furniture or cabinets. Neatly label your drawing with the following: your name, the date, what room you drew, and the scale of the drawing. (Drawing scale: 1/4 inch = 1 foot)
- Find out about three career opportunities in architecture. Pick one and find out the education, training, and experience required for this profession. Discuss this with your counselor, and explain why this profession might interest you.
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Sunday, January 31, 2010
Best Meal of the Millennium
I met up with fellow PPK-er/vegan blogger Erin of Vegan Homemade at Millennium on Thursday evening. The only picture of us turned out blurry, but here it is anyway:
As we gabbed about how excited we were to be able to order ANYTHING on the menu, our sweet server brought this Crusty Bread with White Bean Spread to the table:
I'm so used to eating plain bread at restaurants since the butter most places offer isn't vegan. But I happily schmeared this spread all over the chewy, white bread.
Erin and I split a bottle of grenache/syrah/mourvedre. All their wines are organic and vegan! And we chose a couple of appetizers to start with — Fried Oyster Mushrooms with some kind of Sweet and Sour Dipping Sauce (I asked for menus so I could blog the formal names, but ended up forgetting to take them):
These mushrooms were the second best part of the meal (I'll tell you about my favorite part in a second). I purchased the Millennium's Artful Vegan cookbook while I was there, and this recipe is included ... so I will certainly be trying to re-create them soon.
We also whet our appetites with this Black Bean Torte:
Smoky black beans meet sweet, caramelized plantains inside a whole wheat tortilla. The torte is drizzled with cashew sour cream and served with pumpkin-habanero salsa verde. So, so good.
I had a really hard time choosing an entree, considering that a) I'm an indecisive Libra and b) I'm not used to actually having more than one or two choices in a restaurant. But I finally decided on the Caribbean Jerk Tempeh:
The salty-sweet tempeh filets were served with coconut and achiote root stew, sauteed kale with caramelized onion and sea veggies, garlic mashed sweet potatoes, and clove-spiced pickled carrots. Absolutely delectable. My favorite part was the coconut stew, but they didn't put much on the plate. Also, the sea veggies (Erin guessed it may have been wakame ... I couldn't tell) in the kale were really tasty.
Erin ordered this Portabello Mushroom dish:
I don't remember what all the side dishes were, but it was served atop some kind of savory chickpea stew with green cauliflower and a millet cake. I took a bite of her mushroom, and it was delicious — smoky with a hint of something like Ethiopian berbere spice.
By the time we finished all this food, we were stuffed. But there was no way we were leaving without dessert. We decided to split something, but our awesome server hooked us up with a complimentary plate of house made truffles, cookies, brownies, and fruit:
So we broke each cookie in half and savored each bite. Then we dug into the dessert we chose to split — Millennium's famous Chocolate Almond Midnight:
This was by far the highlight of my meal. A mocha chocolate filling and super-creamy white chocolate mousse sits atop a crunchy almond toffee cashew crust. The pie is served with a bit of raspberry sauce for dippin'. OMG ... this was heaven in my mouth. Unlike most creamy vegan pies, this didn't taste at all like silken tofu. We couldn't figure out how they made it, but I would make the trip back to San Francisco tomorrow if I could ... just for another slice of that pie!
Well, that concludes the best fancy meal of my life so far. I'll post the rest of my San Francisco food pics on Monday night.
30 comments:
- Serena said...
YUM! That food all looks so GOOD, especially the portobello mushrooms. Next time I'm back in the Bay Area I will definitely go there!
- January 31, 2010 at 10:00 PM
- Mike K said...
I've heard about Millennium, but this post puts it on my list of places I need to visit. Everything looks dazzling and delicious. I ate at a truckstop with some friends today - oatmeal and toast, thank you - and this is the exact polar opposite of that experience.
- January 31, 2010 at 10:08 PM
- nora said...
oh gosh! no wonder you were converted to fancy foodism! your entree looks even better than dessert though! i think that's exactly what i would have ordered!
- January 31, 2010 at 10:59 PM
- Cara Sheppard said...
I love love love Millenium Restaurant! My hubby (an omni) and I went there for our second wedding anniversary, and it was seriously the best meal either of us had ever eaten. I'd go back to San Francisco (one of my favourite cities) and Millenium in a heartbeat. Thanks for the great post!
- February 1, 2010 at 12:16 AM
- Dani said...
wow that all looks so freakin' good!! I absolutely must go there if/when I visit san fran (I've never been, and I live in LA, a sin I know). Glad you two had fun, looks so delicious, especially that pie!
- February 1, 2010 at 12:40 AM
- T said...
Oh my goodness, looks like a dream meal. Especially the black bean torte, I want to make that! And that jerk tempeh looks absolutely fabulous, that's what I would have ordered too.
- February 1, 2010 at 3:09 AM
- Vegan Valerie said...
That looks so good!
- February 1, 2010 at 3:30 AM
- Michal said...
Holy crap every thing looks so yummy! I have heard that the Millennium is the place to be if your searching for a delish food experience. Thanks for sharing it with us :)
- February 1, 2010 at 6:07 AM
- Lisa said...
Millennium really does rock. Glad you had a great meal there!
- February 1, 2010 at 6:58 AM
That looks AMAZING! Especially the desserts ;-)
- February 1, 2010 at 8:14 AM
- vegan.in.brighton said...
Oh yum, everything I see from Millenium always looks amazing, I need that chocolate dessert right now!
- February 1, 2010 at 9:01 AM
- a-k said...
Yummy! One day I will get there, but it isn't often I find myself in SF with enough time (and under the right circumstances) to be going to Millenium.
PS - The chocolate Almond Midnight is in their first cookbook, which I have. Lemme know if you want the recipe!
- February 1, 2010 at 9:12 AM
- Shannon-Rabbit Food said...
Oh my word! So much amazing looking food. How does so much deliciousness fit into tiny little Bianca?
The great, wonderful mysteries of life.
- February 1, 2010 at 10:37 AM
- Leslie Richman said...
That all looks SO good!!
- February 1, 2010 at 10:40 AM
- Samantha Angela @ Bikini Birthday said...
the portobello mushroom dish looks fab!
- February 1, 2010 at 11:01 AM
- Jess - The Domestic Vegan said...
I love, love, love Milennium. Your visit looks delicious! I NEED some of those oyster mushrooms immediately. I might have to buy that cookbook...
Can't wait to hear about the rest of your trip!
- February 1, 2010 at 11:45 AM
- Holy Moly said...
I ate there for the first time a few weeks ago and was also blown away by the food! I had the pumpkin curry and the raw seaweed salad...TOTALLY DIVINE!
- February 1, 2010 at 12:10 PM
- dreaminitvegan said...
It's so nice to be able to go to a restaurant and order anything on the menu. Someday I will get to that restaurant. I've checked out that cookbook and many of the recipes are pretty detailed and alot of steps but they are really good. The food looks so good.
- February 1, 2010 at 12:14 PM
- Erin said...
Your pictures turned out fantastically considering the lighting! It was so nice to meet you, and the meal was fabulous!
- February 1, 2010 at 2:28 PM
- Spiele said...
the porttobello dish looks so pretty I wanna try it
- February 1, 2010 at 2:44 PM
- Cassie - Vegan Fox said...
How lucky! I'm definitely jealous, we don't have many options here. I need to get out of town...
- February 1, 2010 at 3:12 PM
- two vegan boys said...
Wow. The food looks beautiful and delicious.
- February 1, 2010 at 5:14 PM
- Veg-In-Training said...
Wow that brings back great memories of our trip to Millenium and wine country. Looks out of this world!
- February 1, 2010 at 6:01 PM
- Paul Capestany said...
Millennium and Candle 79 (in NYC) have served the most amazing food I've ever eaten. Soooo good.
- February 1, 2010 at 7:59 PM
- jessy said...
so awesome that you got to meet Erin AND enjoy yummies at Millennium! i've heard nothing but super stellar things about that place! the chocolate almond midnight sounds like the best thing ever - and so do the oyster mushrooms. i had no idea they had a cookbook. amazon wishlist. yay! i'm so jealous of all the delicious fancy pants yummies you got to enjoy, Bianca! :)
- February 2, 2010 at 1:25 PM
- Christine said...
Wow, it all looks good. Cute bread animals! I need to get to Millenium on our next trip to the city!
- February 2, 2010 at 11:14 PM
- Alice said...
I really look forward to going back to SF and finally try that restaurant. Everything looks delicious!
- February 4, 2010 at 3:57 PM
- Melisser; the Urban Housewife said...
Chocolate Almond Midnight has been on the menu since they opened! It's the best. The guy who created it now works at The Plant Cafe. I love that mushroom dish too!
- February 5, 2010 at 3:52 AM
- The Bad Vegan said...
we went to Millennium on our honeymoon in SF and it made me feel so...normal. like you said, being able to choose from anything on the menu is awesome - and everything there is delicious. i'm so glad you got to go :)
- February 5, 2010 at 7:30 AM
- book publishing company said...
My gosh! no wonder you were converted to fancy foodism! your entree looks even better than dessert though! i think that's exactly what i would have ordered!
- April 28, 2010 at 10:53 AM