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Topic: {IC} Those Left Behind (Read 58192 times)
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Re: {IC} Those Left Behind
Reply #15 on:
January 11, 2010, 04:56:51 pm »
"You'd better not start yelling again Billie." Was all that Ignot said, as he walked out of the hallway. This wasn't a dismissal motion and luckily Billie knew that, because she fell right in tow behind him. After walking into the common room, Billie took her customary place on her couch, holding her hands in her lap in that classic submissive pose she took when she was around him. But her eyes belayed that obvious body language with a fire nad passion all her own. It was quite admirable and if she could ever cast aside the care she had for people, she would be a formidable person indeed.Pushing that thought aside, he just leaned on the wall close by and stared at her, waiting on her to present her point. She took a deep breath and sighed, looking back at him once more.
Billie exhaled heavily, shoulders sagged as she willed the tension from her body. She felt a pang of anger at how he positioned himself and looked down on her...she felt like whatever she said wouldn't make a difference, but most of all yelling would get no one nowhere. "Ignot, its dangerous and unnecessary," she started firmly, "We have more pressing things we should put out efforts into then...then..." she trailed off unable to think of a kind thing to call Ignot's curiosity since offending him with ill-thought wording would probably get him to walk off. The last thing she wanted a this time.
"It will be a small party. 2-3 People. It could be any number of things, some of which could be beneficial to us." Ignot said, not really shifting in his position at all.
"And who will go? You and who else?" Billie eyes narrowed a bit hoping he knew by now she'd absolutely refuse to allow the younger survivors to go on his wild goose chase. She knew that Ignot was aware that her protectiveness of the teenagers would severely limit his pool of available party members...and in her mind she bitterly thought he probably also knew she'd follow him.
"Myself, You, and most likely Kai, Alex, or the New Corpsman. But Alex needs to get out more and train some. She's been too secluded and her shot is off." Ignot said mater of-factly. Planning operations like this were second nature to him and he had most of the mission planned out already. Billie looked like she was about ready to smack him after those comments about Alex, though.
Billie's eyes widen at how Ignot spoke of Alex...like the teenaged girl was supposed to be a seasoned solider. The doctor's face redden with her anger at Ignot's insensitivity to Alex's emotional distress...almost like he based her value on how useful she could be to him. "Alex is not going..." Billie practically hissed through her teeth, having gotten to her feet as she spoke...not planning to play submissive anymore since Ignot hit a sensitive nerve with her, provoking the usually amiable woman to get closer and closer to loosing her temper.
"As much as i wish to say differently, I agree. She's not going. She's not ready. Kai's here to watch over everyone and to keep morale up, so it's the new corpsman. What else would you like to bring up?" He said, again, almost not even registering the fact that Billie had changed positions. He noticed alright.
"If she gets out of hand, Ignot, you need to take her down. She's a threat to you. To this little kingdom you have here. She could topple everything you try for."
Ignot quickly pushed that to the back of his mind. Illaron was starting to really get on his nerves with his constant quips.
"Billie, you know that we need someway out of here. This is not a good place for anyone. We got raided 3 months ago, but we are in the middle of a densely populated area. As soon as that horde thaws, our movements are restricted once more. This may be our only chance for a while to maybe get a signal out or figure out what's going on elsewhere.
Billie sighed at Ignot's dismissal, raising a hand and pushing back her annoying grown-out hair, the auburn locks falling right back around her face. He had his point, the apartment was the little fortress the survivors would like to think it to be but, "But where is safe Ignot? I'm just concerned you want us to take unnecessary risks...zombies aren't the only threats."
"At this point, everything is a threat. Our best route is to find a way out of these threats. My intentions are the same as yours." Ignot wasn't showing much emotion here, but he usually never did. This was a logic problem here, not an emotional one. If they were to survive, this had to be a logic problem.
Billie bit her bottom lip sharply. She almost blurted out that they may share intentions but he sees this as a chess game and is willing for some "pieces" to be expendable to reach his ends. While Billie knew that wasn't entirely true Ignot didn't make it easy for her to reassure herself that Ignot's plans were in everyone's best interests.
"What other concerns do you have Billie? Do you honestly believe that this apartment will be safe forever? The only way to survive is to be 2 steps ahead of whatever faces us. This is not permanent Billie...." He suddenly found his finger in her face as he also noticed that his voice had crept up in volume. Was this really getting to him? As suddenly as the outburst happened, it faded. Dropping his finger, some of the support left his shoulders and he seemed to sag in the slightest bit.
"Nothing ever is." He turned away from her and started toward his room. This really was taking it's toll on him.
"I'm telling you, Ignot. They are worthless. They are weakening you."
Ignot pushed the thought back in his mind once more. But the bad part was, he wasn't sure Illaron was wrong this time.
Billie's eyes widen at Ignot's small outburst. She raised her eyes from the finger stuck in her face to the red-tinted glasses, her eyes reflecting a bit of upset at Ignot's parting words to her. The doctor watching him leave...seeing now that he isn't as emotional disconnected as he tries to be. "I'll follow you whatever your decision is," Billie said after him in a soft voice to not disturb the others, "I trust you, Ignot." Billie watched his back after this statement...hoping her trust wasn't misplaced.
Ignot stopped and stood in the hall for a few seconds, Billie watching him. He breathed a sigh and looked over his shoulder. "That makes one of us." He then continued down the hall and into his room. It was time to sleep and bury this conversation. It wasn't necessary to survival.
"They aren't either, Ignot."
Ignot sighed once more as he rolled up in his sleeping bag, placing his glasses onto the nightstand next to him.
"Sometimes you annoy me, Illaron." Soon, all was silent.
"May I take a moment to tell you the joys of National Socialism?" - Also Red Beret
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Re: {IC} Those Left Behind
Reply #16 on:
January 14, 2010, 09:06:43 pm »
"Fit you little bastard...fit!" Leland muttered. He forced the pin back into the rifle stock and sighed. Cleaning his weapons helped him take his mind off of his troubles, giving him control over an otherwise chaotic situation. Despite his rifle's uncooperative attitude, he was in good spirits. Earlier in the evening, the leader of the group had told them that they might be scouting out a local part of town.He was eager to help these people who were so generous to him.
His introduction had gone well enough as well. He had let the others know that he had extensive experience in treating traumatic wounds and in basic medical care, and that they were welcome to come to him with any concerns that they had. He switched off his flashlight and worked the charging handle to check the action. Satisfied with his work, he tip-toed to his door and leaned the rifle up against the frame. He could hear voices in the hallway.
"It will be a small party. Two to three people. It could be any number of things, some of which could be beneficial to us."
"And who will go? You and who else?"
Leland felt a lump in his throat. He saw everyone else out in the common room earlier, and when their leader mentioned the trip, many of their faces fell. Something bad had happened recently, he was sure of it. These people were rattled, and even if some were still willing to venture out, they would be better off taking time to properly mourn. He would volunteer to go. That's what tough guys did right?
He heard the older man mention "the new corpsman" and he knew that he was a candidate to go. He also mentioned the Hawaiian, Kai and someone named Alex. Was she the quiet girl? Or was she...the other quiet girl? He couldn't remember.
The woman he was talking to was getting upset, she didn't want them to go at all. Leland felt for her, scouting expeditions are always dangerous, and now with the weather, the danger was higher than ever.
"-it's the new corpsman."
the man said. Leland felt a mixture of relief and tension, he would have some trouble sleeping tonight, but he felt good about taking someone else out of the dangerous trip. If that was the sacrifice he had to make, he would gladly step up to the challenge.
Last Edit: January 16, 2010, 02:28:38 am by SharpArcher01
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Re: {IC} Those Left Behind
Reply #17 on:
January 19, 2010, 04:22:48 pm »
The next day.
Ignot didn't really wake up. It's impossible for someone to wake up that never went to sleep. Or sleep in the classical meaning on the term. He always slept "with one eye open" the phrase went. Scientists would say that he never went into REM sleep, or Random Eye Movement. This is when the person is truly out of it and knocked out. Ignot's many years trained him to sleep light.
His eyes didn't stutter open, there was no sudden movements, nothing at all that showed he was awake in any means. Even his breathing remained constant. Taking stock of his situation, his eyes darted from one section of the room to another, making sure it was clear before he heaved a heavy sigh. Another day. Hell would have been a vacation for some people from this situation. To Ignot, it was just another day. Constant stress, looking over one's shoulder, and killing was normal living for him. Protecting others and making sure they didn't snap? Well that was as foreign to him as a Jamaican in a Blizzard.
Swooping his legs off of the side of the bed, he stretched for a second and grabbed his sunglasses off of his nightstand. They had kept blood out of his eyes before in situation where normal people didn't think to put them on. And luckily the lenses were transparent enough so that he could see at night with ease. Slipping a pair of combat boots on, he climbed out of the sleeping bag and immediately started doing push-ups on the floor. 100 sounded like a good number to start with today. This was his morning reutine. Get up about half an hour earlier than everyone else, workout, then take a solar shower as everyone was getting up. It had been a good pickup by Kai in a Dick's Sporting Goods store. The thing used a solar battery to heat up the water, and it was a relief to have warm water, even for a while. He was always the first in as well.
Finishing his set up, he immediately got up and started crunches on the floor.
"Always the tenacious one, aren't you?"
Ignot sighed in the middle of his set.
"You're getting up earlier, Illaron." He said to himself. This was mostly why he woke up early.
"It is because you are too, my friend."
"I'm not your friend, Illaron. Nor will i ever be." More quick exhalations as he wrapped up his crunches. They found a small pull up bar that attached to the doorframe. Ignot used it fairly often. Starting, he touched his chin to the bar and went back down.
"Aw, why so quick to resort to hostility? I've have been around for a long time now. Can't we just let bygones be bygones?"
"No. You are trying to let them die." Ignot said, short huffs of exertion in between his reps.
"Yes. But that's a small aspect of it. I want you to be strong, Ignot. To be what you trained to be."
He dropped to the floor and started doing lunges in place under the bar.
"I was trained to kill. These people are not trained for that. They need someone like me. They need to survive." Luckily, Illaron wasn't pushing his buttons this morning. That lead to bad days.
"They do not deserve to survive if someone has to take care of them! Even your targets couldn't defend themselves when you attacked. That's how you rationalized it then."
"You are right. But i am not that person anymore. Now if you don't mind, I'm working out." Ignot's dismissal did not work all the time, but after a short while of no more quips from Illaron, Ignot sighed. He couldn't figure out what was worse. That was was clearly off his own rocker and realized it, or that he couldn't get help for it even if he wanted to.
2 hours later, Common Area
"I called a meeting because we need to train." Ignot once again, went straight to the point. Several puzzled and scared looks were passed between the survivors, but no one interrupted.
"With the deaths of recent, We need more people ready to deal with the threats that face us. We will encounter not only zombies, but humans as well, who are not very inclined to our survival. Most of you are not ready for a conflict like that. So we are heading to an apartment building nearby. The older family members will remember that we had to retreat out of this building after our predictions on zombie numbers were very, very wrong. We only cleared the first two floors before retreating out. There are twelve." Again, more small talk. He waited to continue until the side conversations died down.
"Standard sweep and clear. Room by room, two people per room. Wait until we are finished sweeping to scavenge. Gather till you are full, and look for the shopping list. Speaking of which, Billie, what's on the list this time?"
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Re: {IC} Those Left Behind
Reply #18 on:
January 20, 2010, 04:43:11 am »
"Our Father, who art in Haven, hallowed by thy name. Thy kindom come, thy will be done on Earth as it is in Haven. Is that right, Mama?"
"Almost. Very good, Little Bear, I'm so proud of you for coming such a long way in such a short time."
Bethany could tell by the slow puckering of his lips that little Anthony Fleming was upset that he hadn't gotten the words right. The school teacher had always known him to be an eager child who loved it when he was correct. A soft smile passed across her dried, cracked lips as she felt relief that he could still behave so normally, when the world had gone to Hell. Literally.
"Let's try it again, hmm?" she asked kindly to the youth, who nodded vigorously while smiling, his two front teeth wriggling about from the violent shaking. It was only a matter of time before they fell out, either one after the other, or in a pair. Kneeling down beside Anthony, Bethany faced the cracked, dusty window in front of them, where a pale light filtered through, and raised her right hand to her forehead as she began to make the sign of the cross, murmuring loud enough for her student to hear, "In the name of the Father, the son, and the Holy Spirit. Amen."
"Amen," repeated Anthony, mimicking her movements. It was dark, the window not letting in much light, and it was cold, but when Tony was with Mama Betty, he always felt warm inside, so the cold didn't really bother him. Neither did the dark. He listened intently as Beth began to recite the prayer:
"Our Father
Who art in Heaven
Hallowed be thy name
Thy kingdom come
Thy will be done
On Earth as it is in Heaven.
Give us this day, our daily bread
And forgive us our trespasses
As we forgive those
Who trespass against us
And lead us not into temptation
But deliver us from evil. Amen."
"Amen," Anthony said again, with more enthusiasm. "Hey Mama?" he asked, his head inclining to the side ever so slightly.
"Yes, Little Bear?" Bethany responded, looking down at the little boy and smiling, "What is it?"
"When the prayer says we're supposed to forgive those who tr...who tre...tres...pass...against us...do you think God meant that we should forgive them, too?" the boy asked. Bethany didn't need to ask who he was asking about; she could hear them down below, constantly moaning and shuffling about. For just a moment, the teacher's eyes shadowed, the wrinkles around them suddenly very noticeable, along with her pale face and chapped lips from the cold. Then she shook her head firmly, and looked directly at Anthony as she spoke.
"No, Anthony," she said, and the boy knew she was being serious as she spoke his first name, "the Lord did not mean forgive them, for they are nothing but the evil that we, his children, have created from our own selfish ways. They are Evil, and evil does not deserve to be forgiven, instead they must be struck down in His name, so that those of us left may truly live as He meant for us to." She saw Anthony nodding again, slowly this time, and knew that his innocent brain was attempting to understand everything she had told him. In a way, she was glad he couldn't fully grasp the concept, because it meant he was still untainted by everything that had happened, and she hoped that would never change.
"Come on," she said, standing up and holding out her hand to help him do so as well, "why don't we go see how our friend is doing, hmm? Go get your bat." As the child ran over to the corner where his junior baseball bat, made of shiny aluminum, stood up in the corner next to a large blue crowbar, Bethany moved her right hand to her hip, flipping the button to the holster residing there, and lifted the handgun from its holster. She didn't know much about guns, and it was only out of desperation that she had lifted this one from the corpse of a police officer lying outside the station, along with the extra clip of ammunition. She did know how to shoot and reload one, however, and she thanked both God and her father for having the sense to teach her how to defend herself. The memory of her father sent a pang of sorrow through her heart, however, as she once again wondered if he and her brother were alright, or if they were dead. She didn't have time to worry about them, however. They were far away, and she had responsibilities here, both to herself and to Anthony.
She ejected the clip and took a brief count of how many rounds were left; she had already had to use on the way over. There were three missing, which meant she had six bullets left. Coupled with the extra clip, that left her with fifteen shots, total. She slammed the clip back into place and chambered a round, then walked over to Anthony, who was setting his bat to rest on his shoulder, and picked up the crowbar. She didn't want to waste any more ammunition than was absolutely necessary, but she did not trust these abominations to stay put on the floors below them. She let the crowbar rest on her shoulder, the natural curve fitting snugly in place, a perfect puzzle piece. She then motioned for Anthony with two fingers shaped like bunny ears, which he recognized as the signal to stay close behind her at all times. They then proceeded through the door of the room and down the hallway, entering another room and holstering the gun.
"Good morning, and God bless, Mr. Holstenski," Bethany said to the other survivor she and Anthony had come across in their travels...
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Re: {IC} Those Left Behind
Reply #19 on:
January 21, 2010, 08:22:48 am »
Moaning. Everywhere the moaning. Harry was walking down a street, wreckage and decayed bodies scattered everywhere. The ever-present moaning was getting louder. He glanced back and saw a huge horde not far behind him, so vast that he couldn't see the far end of it. A noise made him look forwards again. Shambling out of a wrecked shop window display was one of them. He recognised her, even with most of the left side of her face missing and one arm gone. His wife.
Harry raised his shotgun and pulled the trigger. Nothing happened. She kept staggering towards him and the horde advanced as unstoppably as a glacier.
Harry ran. The streets became a blur as he ran for his life. His lungs burned and his legs ached. Yet he could still hear them behind him, easily matching speeds with him and even drawing closer, despite the fact that they walked just as slowly and without coordination as ever.
A hand grabbed his ankle, tripping him. More hands grabbed at him, pulling. The faces of the undead were all he could see. Teeth sank into him.
Harry awoke with a scream, jumping out of bed and pointing his revolver. After a few deep, ragged breaths, he lowered the weapon and sighed. He sat on the bed and took out his hip flask, taking a few swigs to brace himself against the horrors of the day.
Once ready, he left the room.
"I called a meeting because we need to train. With the deaths of recent, We need more people ready to deal with the threats that face us. We will encounter not only zombies, but humans as well, who are not very inclined to our survival. Most of you are not ready for a conflict like that. So we are heading to an apartment building nearby. The older family members will remember that we had to retreat out of this building after our predictions on zombie numbers were very, very wrong. We only cleared the first two floors before retreating out. There are twelve."
Harry raised his hand. "So how'll killing more zombies make us ready to kill people?"
Truth be told, Harry thought he was already ready to kill people. He wouldn't want to, but you did what you had to.
Last Edit: January 21, 2010, 08:24:22 am by Cheez
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Re: {IC} Those Left Behind
Reply #20 on:
January 21, 2010, 05:10:38 pm »
A hand raised in the room before Billie could talk. Ignot looked over at the hobo that they had run into not too long before. They were retreating down an alleyway when Jason bowled him over. After a brief scuffle that left Jason with a split lip and a sore arm, Harry joined the group. But he didn't wait for recognition from anyone before speaking up.
"So how'll killing more zombies make us ready to kill people?"
Ignot didn't stiffen, he didn't flinch. Just stood there, arms crossed, looking at the man. After a short time, everyone stopped talking in whispered tones and it got really quiet in the room. Harry even looked away, looking to the others for a little support. But eventually, his gaze directed back to Ignot.
"I don't think anyone is ready to kill someone." Ignot said, voice just as solid as it normally was, but there a twinge of something. Regret maybe? No one could really get a hold of what it was.
"This mission's only to get your responses down. You have to sort out targets. Determine which is a threat and which isn't Those instincts are very much lacking in this group and I'd rather have us ready for anything over ready for nothing. The only way to develop those senses is to practice. Better it's on our terms then someone else's."
"Billie, let's hear the list."
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Re: {IC} Those Left Behind
Reply #21 on:
January 21, 2010, 06:22:46 pm »
Harry didn't look away. He met Ignot's with the same emotionless face he usually displayed.
"I don't think anyone is ready to kill someone. This mission's only to get your responses down. You have to sort out targets. Determine which is a threat and which isn't Those instincts are very much lacking in this group and I'd rather have us ready for anything over ready for nothing. The only way to develop those senses is to practice. Better it's on our terms then someone else's."
"Fair enough." he replied.
'Which is a threat and which isn't'? An apartment block will be close quarters fighting, and from what you said, there'll be a lot of 'em.
will be a threat.
And I highly doubt anyone here'll have survived this long without picking up those instincts.
Despite his thoughts, Harry said nothing, instead merely looking to Billie.
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Re: {IC} Those Left Behind
Reply #22 on:
January 22, 2010, 02:53:47 pm »
Alex woke up with dull pains in her arms. She looked at her bandaged arms to see that the blood seeped through the heavy bandaging. She sighed and walked into her bathroom and quickly changed them out. Her arms were a mess, but she didn't even give it a second thought. She put on her pilot's hat and jacket and went upstairs for breakfast. She figured that she could get breakfast and then just sit outside on patrol, it seemed like a good day to do such a meaningless task.
"I called a meeting because we need to train."
Alex rolled her eyes at Ignot. She didn't want to train and he wasn't going to force her to do it. She finished her breakfast and looked at Ignot before she put her bowl in the sink and headed up to the rooftop to start her patrol.
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Re: {IC} Those Left Behind
Reply #23 on:
January 25, 2010, 03:43:09 pm »
It's gonna be a hard week. Those boards ain't gonna hold forever. Goddamn cheap apartments.
Frank Holstenski was in a bad mood. he had been up for a good two days checking and rechecking the makeshift barricades he had set up. He looked and felt as in a fugue and his worries didn't stop with the pathetic little boards he had used as barricades either.
Franky sighed and patted the crowbar against his meaty palm. Dried up blood flecked off the sharp end of it and settled into his open hand. He glowered at the floor and tried not to fall asleep. His thoughts drifted off to Summer and the dull hope that maybe, just maybe, she was out there waiting for him.
Yeah right big man. She's gone. You need to snap the fuck out of it. Quit holding on and go. You got a lady and a kid that need looking after. If Summer is out there, she is smart enough to fend for herself without you worrying about her.
He grimaced at his own thoughts.
He jumped when he heard "Good morning, and God bless, Mr. Holstenski.". His heart racng he put his head in his hands and murmured back "Hey there Beth. How many times have I told you it's just Franky though?" He said the last part with a slight smile though and turned around to face the woman. As usual, the kid wasn't more than an arms length away from the side of Bethany. "Hey there little man." He said with a goofy grin.
Priorities. Keep em straight Franky. You never had a problem with that before, so don't you start now.
His grin disappeared and he sighed as he turned back around to keep watch.
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Re: {IC} Those Left Behind
Reply #24 on:
January 30, 2010, 05:12:32 pm »
Common Area
Billies gaze was off to the side, the usually sharp hazel eyes almost glazed like a person sleeping with their eyes open. The doctor was miles away from the conversation at hand around her, not registering the chatter or Ignots plan for their training. Her disagreement with Ignot had taken Billies thoughts to a time before the dead and the faces spawned from these memories had made sleeping very difficult.
"Billie, let's hear the list."
The woman jumped and turned her eyes to Ignot. For a moment the womans face reflected how out of touch she had been with those around her, her confusion quickly melting into an embarrassed flush across her cheeks and nose at realizing her lack of attention had halted the discussion.
She stalled a second by clearing her throat before speaking in almost a hoarse way, The usual supplies: any salvageable, sealed foods and bottled water. Medications, such as aspirin and anything that could be useful to add to the first aid supplies. Ammunition weapons. Winter clothing and boots, blankets the weather isnt getting much better
The womans eyes had wandered off the side again, her thoughts rushing faster than her mouth could keep up with so her sentences were choppy and scatter brained. Billie rubbed her temple with two fingers, glancing around the table through her bangs and noting the only empty seat.
Leland, do me a favor and go check on Trista Billie voice had a hint that her request was actually a polite order. Leland was the obvious choice after herself since he had some medical knowledge. Trista usually needed help with her bandages. Worse that could happen was the teenager refused help from Leland though Billie failed to take into account that Leland, nor anyone else excluding herself and Liam had seen the extent of the girls injuries.
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Re: {IC} Those Left Behind
Reply #25 on:
January 31, 2010, 04:29:50 am »
"Hey there little man,"
said the giant to Anthony, smiling in a silly fashion. This made the child stifle a giggle before looking up at Bethany, unsure of what to do. Bethany smiled back and placed the fingers in her left hand above her thumb so that they touched together, then opened and closed them in a mouth-like movie. Tony immediately understood the signal, and said back in a shy voice, "Hiya Mr. Hol...Mr. Hollystenk......Mr. Frank!"
Bethany smiled and patted Anthony on his head, watching the boy wander around the room with his bat dragging behind him before turning back towards Frank and stepping forward so to be standing beside him.
"I suppose you're right," she said with a soft smile at the man, "but I hope you'll have it in you to forgive an older woman her habits, Mr. Holstenski." She looked around the room, noticing how well prepared the barricades he had set up of the last two days were looking. "You truly have a talent, and God only knows what would have happened to me and Little Bear if you weren't around," she continued, tapping the boards lightly with her own crowbar, the lack of red stains on it a noted contrast to the foreman's own bloody tool. She turned to look at Frank and saw his worried appearance. Gently, Bethany reached out and placed a hand on one of his broad shoulders.
"We'll find a way out of this, Mr. Holst...Frank," she said quietly, "by the Father, I know we will find a way."
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Re: {IC} Those Left Behind
Reply #26 on:
February 01, 2010, 02:10:17 pm »
Franky rolled his shoulders and rubbed some more of the blood specks away from his crowbar. "And if we don't find a way, I will make one." he growled.
The violence his voice promised scared him a little. Sure, he had speared a couple of these freaks in the face with his crowbar...but it was either that or die. Before corpses started to eat people, Franky would've never thought of hurting anything. He had had enough of fighting and violence in his life already. But now, it seemed violence was the only way. He flexed his arms, corded with muscles borne of hard labor, as his thoughts gave him a boost to his wavering resolve.
In a quieter voice he added, "I've gotta get some sleep soon. These things crawling around outside are driving me nuts-o."
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Re: {IC} Those Left Behind
Reply #27 on:
February 01, 2010, 04:01:20 pm »
Ignot looked around after Billie got Alright. We move out in an hour. Get weapons checks done, make sure melee weapons are in functioning order. Remember, if you need extraction, don't start screaming, knock on the wood around you. If you hit it hard enough, one of us is going to hear you. Form up in teams and remember to cover your backs. We are walking this time around, so bundle up. Only use weapons as a last resort. Move out."
1 and half hours later
Kai volunteered to stay behind with Trista while the rest of the group went out to this apartment for the salvage mission. Ignot looked behind him at the walking line they had adopted for this trip. He stopped for a second and looked upward, looking for the building they had trekked a half hour to get to but his vision quickly blurred as the wind slammed into him, doubling him over for warmth. He didn't mind it much ,but he knew that some of the others must have been complaining. He had heard many things about Philly weather, but the actuality was so much worse than the myths... Once the wind had passed, he looked up again only to see the towering brick building in front of him, balconies long since empty from human use, the snow piled high outside of the windows that were still standing against the wind. The pale staccato was flaking so many places, it was hard to tell what the original colors of the building were, but the building looked fairly modern. Which was good for them because it meant less likely hood of a cave in or rotten floors.
A small abstract sculpture stood in a courtyard between the building and it's neighbor, which had already been searched by the group previously. It was tall sculpture, with wires that seemed to twist up into a cone type of shape from the ground. But Ignot was never one to admire art. The things he picked up was that the sculpture lay in a walled in garden that was long dead from winter, even with the waist high walls of brick, the windows from both buildings could still overlook into cover. It was a deathtrap and the entrance to the buildings were only open from there.
Holding up his hand to signal the rest of the line to stop, he looked back to see the sign being copied right down the line. 'Good,' he thought. 'They are learning from my lessons. Swinging his hand in a circle above his head, he motioned to a small cafe across the street from the apartments for the group to huddle up in. Shuffling over, they all grouped up around him and took the time to shake the cold out of their bones, a lot of them stretching their bodies from being hunched up from the cold for so long. Alex pushed her scarf down her face and looked over at Ignot.
"I remember that being a shorter trip last time." She said, a small hint of her previous humor showing itself again. Ignot smiled, but no one could see it.
"Last time we drove." Looking back over the group he pointed over to the building framing the window behind him.
"This is Evac point Alpha. Get here in case of zombie trouble. This is a large entry point covered by a bar and a lot of small obstacles to prevent them for a little. Lets get this over with quickly ladies and gents and we'll eat well when we get home." Alex stepped up as well.
"Kai hinted at meatloaf." Mummers of hunger and anticipation traveled through the group as they shuffled forward toward the window of the Cafe. Alex stayed back with Ignot and looked up at him before covering her face again.
"Why no Evac Beta, Ignot?" Ignot only re-shoulder his backpack and double checked the magazine on his Pistols.
"If we need an Evac Beta, it's a lot worse than a new Evac Point can help us with. Now come one, you are with Liam."
"May I take a moment to tell you the joys of National Socialism?" - Also Red Beret
Posts: 636
RP Mercenary
Re: {IC} Those Left Behind
Reply #28 on:
February 05, 2010, 02:21:51 am »
Leland pulled his jacket tight around his shoulders; he wasnt used to such cold weather at all. Here he was: out in alien territory, a strange place, behind enemy lines. In the back of his mind he knew that this wasnt the kind of adventure hed had in mind when he joined the Navy.
It was a long walk to the destination, but the wind and the sun reflecting off of the snow screwed with his perception, making him squint. He took a moment to survey the area; square brick buildings, all around. It was so far away from his suburban cottage and the storefronts of New Orleans. For the first time, Leland felt homesick.
After a while, Ignot held out his arm at a right angle and balled up his fist, the universal sign for stop. Leland was surprised, this man knew more than Leland had imagined. Leland repeated the signal and knelt down in the snow. Soon, they huddled up along side a building to get ready. Ignot had explained that it would be a scavenging mission. Nothing new there, Leland had carried out quite a few in the last few months for his own survival.
Just keep your eyes peeled and be quiet as death itself.
He thought to himself. Ignot and the others were talking, but something was nagging at his brain.
Death itself huh. I guess Weve all seen death itself. And her I cant imagine what shes seen.
His mind wandered back to earlier that day.
Leland, do me a favor and go check on Trista. It was Billie, a doctor who Leland came to respect for her tenacity.
Uh, y-yeah. Sure. He stood up quickly and entered the hallway.
Was it to the left or the right? he whispered to himself.
After a few minutes of playing search and rescue he managed to find Tristas room. He knocked on the door.
Uh, hello? Trista? Its-uh he wondered if she even knew who he was. Its Leland. The new guy. No answer.
I hope youre decent then, b-because Ms. Billie asked me to come check up on you and I intend to oblige her. So uh, Im-a open this door now. He turned the handle, pushed open the door, and immediately began studying the ceiling. He was a gentleman after all.
Trista? Yalright? he asked the ceiling.
Trista was looking at the door intently; mind unable to put a face to the name. She could not figure out why this person was disturbing her. She gave him no response hoping whoever was on the other side of the door would leave her to her solitude. The teenager had no desire to be a part of neither the meeting nor the mission.
I hope youre decent then, b-because Ms. Billie asked me to come check up on you and I intend to oblige her. So uh, Im-a open this door now. He opened the door and stepped in.
Trista watched the scrawny young adult with disinterest. He was staring at the ceiling probably for the best. Her fingers twitched around the bandages in her hand, a bit on edge because she had just removed them.
When Leland looks down he would be faced with one striking green eye and one white one the girl blinded in one eye from the deep, white scars across one side of her face. Trista didnt give him much time to examine the extent of her injuries before asking him in almost a hiss what he wants.
Leland tilted his head down and saw Trista out of the corner of his eye. Good, your decent. He said quietly. The lights were off, but he could see she was holding a bandage in her hand. Leland took a step forward and knelt down beside her, rolling up his sleeves.
Whatcha got here darlin? You hurt or something? he turned his head up to look her in the eye, and recoiled, almost falling over. Aw Jesus! He whispered.
Before he could react, the girl asked him what he wanted.
Still reeling, he fumbled. He wasnt even sure why Billie had sent him in here in the first place. He wiped his brow and tried to speak.
I uh, fbuh, I, me? I am, I am here to uh, for lemme, uh, lemme take a look here. He reached out for her arm, the scars looked painful and he felt that Billie had sent him in for this reason.
The girl had removed her hoody for the tedious process of changing her bandages the teens body thin from her not being too eager to eat but retain most of her muscle tone she gained from athletics before the world fell apart. She look very unwelcoming to say the least, the girl sitting on the edge of her bed, her skinny frame exaggerated because she is hunched over holding the bandage.
This close Leland can see she has tensed noticeable at his presence probably because even in the low light he can see the scars trailing down her upper arms and the clawing become uneven around her hands as though she had tried to left them to protect herself. Tristas fingers showed the scarring of having once been broken this fact made even more obvious when the bones in her fingers pop as she clinches them around the bandages due to Leland physical recoiling at the sight of her.
When he touched her arm, the teens eyes narrowed he could feel the tension in her body, like she wanted to strike him. But rather than hit him, her voice spoke to him coolly, I dont need your help get out.
Leland stiffened at her voice. He had heard that tone many times before, but never from someone so young.
N-n-now now. I-I know you prolly dont like having to have someone take care of you, and lots of people dont like doctors, but uh I know you dont need any help with bandages. Youre a big girl. Im here to just check on you for Ms. Billie. He said.
And Id sooner kiss a cow than be on the bad side of that lady. He chuckled.
Indeed, Billie was a real doctor, not like him. She trusted him to do something here, and he would not disappoint someone who helped so many people. He had to do this. He turned his head up and looked Trista in the eyes.
Ill be quick. I promise. Just relax. He moved his hand to her chin and gently turned her head to inspect her face.
He thought.
This is so fucked up. She's just a kid
He started to hum a bit, You Are My Sunshine. In his time providing care, he found that it helped calm himself, and occasionally his patients.
He looked into her pale white eye and bit his lip.
Trista continued to glare at the man. His stutter was causing her a great deal of annoyance she wasnt sure why it was making her angry or why she was interpreting it as fear and weakness. This conclusion of the mans spinelessness seemed affirmed by his fear of the doctor. The teen parted her lips to tell Leland to leave again when he touched her face, turning her head causing her to go absolutely still.
In a quick motion she reached for her hoody Leland probably getting a nasty scare when he saw the gun holster on top of the sweater. However,what the girl was so desperate to have, was a badge Trista clutching it in one hand and running her numb over the face of, it had become a way for her to calm herself. Slowly she lost the tension, eyes shut and trying to block out Leland, the humming actually helping her block out the aggravating and at moments painful thoughts. It was enough for him to apply the new bandages.
When the humming and bandaging ceased, Trista opened her eyes and frowned at the expression on Lelands face. The teen turned her head enough to move her dark hair over her face, hiding the blinded eye. If its so disgusting stop gawking at it
Leland felt a pang in his chest. He felt like an ass. He slowly stood up and rolled his sleeves back down.
Alrighty, youre all set now. Everything seems ok. This was tiring he was getting sick of beating around the bush. Look, youve been through something horrible. I know that much. And while I cant just say Itll all be alright, you gotta know that were all here to make it as close to alright as we can.
He stood there for a minute, then turned and stepped into the hallway. He stopped for one last thing:
You, uh, you need anything-come find me. I got valiums and stuff, if you cant sleep or anything. Ill uh, Ill see you around. He closed the door and slumped down against the way.
That was fucked
Leland snapped back to attention when a bit of snow landed on his neck, melting down his back and eliciting a shiver from the corpsman.
This is evac point Alpha. Ignot stated, pointing out a small building near them.
Now was no time for that. He needed to focus. He would just have to talk to Billie when they all returned home.
Keeper of the ಠ_ಠ
Voted most likely to hug.
Apprentice Zombie Hunter
Posts: 18767
Re: {IC} Those Left Behind
Reply #29 on:
February 05, 2010, 09:32:09 am »
Harry stealthily crept along, making little noise even in the snow. His shotgun hung from a rope sling across his chest to free up his hands. He didn't like the noise some of the others made with their clumsy walking, but that couldn't be helped. He certainly didn't like the single file line Ignot had them in- he'd much rather have people- himself included- out on the flanks, away from the main group. That way, they had a better chance of spotting and avoiding any zombies that might be around before it was too late. Still, Ignot was the boss.
His mental grumbling ceased when Ignot's hand went up. Harry repeated the signal, crouching and grabbing his weapon as he did so. Were they there, or had Ignot spotted a zed?
He gladly moved into the cafe upon Ignot's signal. Evidently, there was no contact. They must have arrived.
"This is Evac point Alpha. Get here in case of zombie trouble. This is a large entry point covered by a bar and a lot of small obstacles to prevent them for a little. Lets get this over with quickly ladies and gents and we'll eat well when we get home."
Harry didn't reply. Instead, he considered his options. They didn't know what was in the back of the cafe- the back door could be locked, or even worse blocked. He didn't like that. Instead, moving down the road and losing the zombies in the alleys and side streets sounded more sensible to him. Eh, he'd see how things were when it went down.
"Kai hinted at meatloaf."
Harry's mouth watered. A hot meal would do him wonders.
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text:
California Department of Transportation
Date: March 21, 2014
District: 3
Contact: Gilbert Mohtes-Chan
Phone: (530) 741-4571
$165 million will upgrade bridges, repair rough pavement,
and keep pavement in good condition from deteriorating
MARYSVILLE – Californians will be driving on smoother roads, safer bridges, and enjoying the benefits of enhanced transit thanks to $334 million in new funding allocated to 53 projects by the California Transportation Commission.
The allocations include approximately $165 million to repair bumpy pavement, preserve roads that are in good condition from worsening, and upgrade bridges to make them safer and stronger. Most of California's highways are more than a half-century old, and they carry nearly half of the nation's container freight – heavy loads that pound our highways more than any other state.
"To get the most bang for the buck for taxpayers, Caltrans targets dollars where they are most effective - pavement preservation," Dougherty said. "Every $1 spent on preventive pavement maintenance saves Californians $11 that would have been spent on future pavement repairs."
Currently, 84 percent, or 42,000 lane miles of California highways are in good operating condition. Caltrans' goal is to reach 90 percent by 2023, which is a challenge as funding is declining and highways are aging. In 2013, Caltrans repaired 76,808 potholes on the Golden State's 50,000 highway lane miles. This was down nearly 100,000 potholes from a few years prior due to Caltrans' repaving efforts.
The allocations also include $64 million from Proposition 1B, a transportation bond approved by voters in 2006. To date, more than $17 billion in Proposition 1B funds have been put to work statewide for transportation purposes.
The remaining funding allocations came from assorted transportation accounts funded by state and federal dollars.
Some of the projects that received funding support include:
- Placer County: $874,000 to widen the intersection of State Route 89 and Alpine Meadows Road near Truckee, install a new traffic signal and build left and right turn lanes.
- Colusa, Butte and Glenn counties: $715,000 to place rock slope protection at five locations and install concrete slope protection near one bridge along various state highways in the three counties.
Please see the attached file for more information about all projects that received allocations.
# # # #

subset: commoncrawl


text:
Cabozantinib-s-malate or Sunitinib Malate in Treating Patients With Previously Untreated Locally Advanced or Metastatic Kidney Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01835158
Recruitment Status : Active, not recruiting
First Posted : April 18, 2013
Last Update Posted : May 8, 2018
- Study Details
- Tabular View
- Results Submitted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Clear Cell Renal Cell Carcinoma Metastatic Renal Cell Cancer Stage III Renal Cell Cancer AJCC v7 Stage IV Renal Cell Cancer AJCC v7
|Drug: Cabozantinib S-malate Other: Laboratory Biomarker Analysis Drug: Sunitinib Malate
|Phase 2
I. To determine if patients with renal cancer treated with cabozantinib (cabozantinib-s-malate) will have improved progression-free survival compared to patients treated with sunitinib (sunitinib malate).
I. To determine whether the response rate of patients with renal cancer treated with cabozantinib will be higher when compared with patients treated with sunitinib.
II. To determine whether patients with renal cancer treated with cabozantinib will have an improved overall survival when compared with patients treated with sunitinib.
I. To determine whether renal cancer patients with high MET expression by immunohistochemistry (IHC) have improvement in progression-free survival compared to patients with low MET expression on both arms of this study.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive cabozantinib-s-malate orally (PO) once daily (QD) for 6 weeks. Courses repeat every 6 weeks in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive sunitinib malate PO QD for 4 weeks. Courses repeat every 6 weeks in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 6 months for 5 years.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|158 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Randomized Phase II Study Comparing Cabozantinib (NSC #761968) With Commercially Supplied Sunitinib in Patients With Previously Untreated Locally Advanced or Metastatic Renal Cell Carcinoma
|Actual Study Start Date :
|July 8, 2013
|Actual Primary Completion Date :
|April 18, 2016
Active Comparator: Arm I (cabozantinib-s-malate)
Patients receive cabozantinib-s-malate PO QD for 6 weeks. Courses repeat every 6 weeks in the absence of disease progression or unacceptable toxicity.
Drug: Cabozantinib S-malate
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Active Comparator: Arm II (sunitinib malate)
Patients receive sunitinib malate PO QD for 4 weeks. Courses repeat every 6 weeks in the absence of disease progression or unacceptable toxicity.
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Sunitinib Malate
Given PO
Other Names:
- Progression free survival (PFS) [ Time Frame: Up to 5 years ]The primary analysis will be based on the stratified log-rank statistic to compare the two treatment arms on PFS. The Kaplan-Meier product-limit estimator will be used to estimate PFS distributions.
- Overall survival (OS) [ Time Frame: Up to 5 years ]The primary analysis will be based on the stratified log-rank statistic to compare the two treatment arms on OS. The Kaplan-Meier product-limit estimator will be used to estimate OS distributions.
- Objective response rates [ Time Frame: Up to 5 years ]The Fisher exact test will be used to compare the two treatment arms.
- Proportion of patients with unacceptable treatment related grade 3 or higher toxicity for all patients assessed using National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 [ Time Frame: Up to 5 years ]The Fisher exact test will be used to compare the two treatment arms.
- High MET expression (total MET and phospho/MET) by IHC [ Time Frame: Up to 5 years ]Will determine if there is an association between high MET expression and better PFS and OS.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Renal cell carcinoma with some component of clear cell histology; histologic documentation of metastatic disease is not required
- Locally advanced (defined as disease not amenable to curative surgery or radiation therapy) or metastatic renal cell carcinoma (RCC) (equivalent to stage IV RCC, according to American Joint Committee on Cancer [AJCC] staging)
Eligible patients must be intermediate/poor risk, per the International Metastatic Renal Cell Carcinoma (mRCC) Database Consortium (Heng) criteria; patients must therefore have as one or more of the following six factors:
Time from diagnosis of RCC to systemic treatment < 1 year
- Note: systemic treatment refers to the initiation of A031203 protocol treatment
- Hemoglobin < the lower limit of normal (LLN)
- Corrected calcium > the upper limit of normal (ULN)
- Karnofsky performance status < 80%
- Neutrophil count > ULN
- Platelet count > ULN
- No radiographic evidence of cavitating pulmonary lesion(s)
- No tumor invading the inferior vena cava (IVC) or superior vena cava (SVC) blood vessels
- No evidence of tumor invading the gastrointestinal (GI) tract (esophagus, stomach, small or large bowel, rectum or anus), or any evidence of endotracheal or endobronchial tumor within 28 days prior to registration
- No prior systemic treatment for RCC; supportive therapies such as bisphosphonates (zoledronic acid) or denosumab are permitted
- Patients must not have had a major surgical procedure or significant traumatic injury within 6 weeks prior to study registration, and must have fully recovered from any such procedure; however, patients who have had a nephrectomy may be enrolled 4 weeks after surgery, providing there are no wound-healing complications; the following are not considered to be major procedures: thoracentesis, paracentesis, port placement, laparoscopy, thoracoscopy, bronchoscopy, endoscopic ultrasonographic procedures, mediastinoscopy, skin biopsies, incisional biopsies, imaging-guided biopsy for diagnostic purposes, and routine dental procedures
- To the brain, thoracic cavity, abdomen, or pelvis must be completed at least 90 days before registration;
- To bone must be completed at least 14 days before registration; and
- To any other sites must be completed at least 28 days before registration In all cases, there must be complete recovery and no ongoing complications from prior radiation therapy
- No chronic concomitant treatment of strong cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) inducers or inhibitors; patients may not have received a strong CYP3A4 inducer within 12 days prior to registration nor a strong CYP3A4 inhibitor within 7 days prior to registration
- Patients must have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) criteria; lesions that can be accurately measured in at least one dimension (longest diameter to be recorded) as >= 2 cm with conventional techniques or as >= 1 cm with spiral computed tomography (CT) scan
No active brain metastases; patients with treated, stable brain metastases for at least three months are eligible as long as they meet the following criteria:
- Treated brain metastases are defined as having no ongoing requirement for steroids and no evidence of progression or hemorrhage after treatment for at least 3 months, as ascertained by clinical examination and brain imaging (magnetic resonance imaging [MRI] or CT); (stable dose of anticonvulsants are allowed); treatment for brain metastases may include whole brain radiotherapy (WBRT), radiosurgery (RS; Gamma Knife, linear accelerator [LINAC], or equivalent) or a combination as deemed appropriate by the treating physician; patients with central nervous system (CNS) metastases treated by neurosurgical resection or brain biopsy performed within 3 months prior to registration are not eligible
- Baseline brain imaging (MRI/CT) is required
- No serious non-healing wound, ulcer, or bone fracture requiring intervention within 28 days prior to registration
- No arterial thrombotic events within 6 months prior to registration, including transient ischemic attack (TIA), cerebrovascular accident (CVA), peripheral arterial thrombus, unstable angina or angina requiring surgical or medical intervention in the 6 months prior to registration, or myocardial infarction (MI); patients with clinically significant peripheral artery disease (i.e., claudication on less than one block), significant vascular disease (i.e., aortic aneurysm, history of aortic dissection), or any other arterial thrombotic event are ineligible
- No history of pulmonary embolism or untreated deep venous thrombosis (DVT) within 6 months prior to registration; note: patients with recent DVT who have been treated with therapeutic anticoagulation with low molecular weight heparin for at least 6 weeks are eligible; patients receiving therapeutic warfarin (> 2 mg/day) are not eligible; patients on warfarin may be switched to low molecular weight heparin at the discretion of the treating physician
- No inadequately controlled hypertension (defined as a blood pressure of >= 150 mmHg systolic and/or >= 90 mmHg diastolic), or any prior history of hypertensive crisis or hypertensive encephalopathy
- No New York Heart Association (NYHA) class >= 2 congestive heart failure
- Ejection fraction on echocardiogram (Echo) or multi gated acquisition scan (MUGA) > 50%
- No corrected QT interval calculated by the Fridericia formula (QTcF) > 500 ms within 28 days before randomization; note: if initial QTcF is found to be > 500 ms, two additional electrocardiograms (EKGs) separated by at least 3 minutes should be performed; if the average of these three consecutive results for QTcF is =< 500 ms, the subject meets eligibility in this regard
- No history of congenital QT syndrome
- No unstable cardiac arrhythmia within 6 months prior to registration
No evidence of any of the following:
- Clinically-significant gastrointestinal bleeding within 6 months before registration; or
- Hemoptysis of >= 0.5 teaspoon (2.5 mL) of red blood within 3 months before registration; or
- Any other signs indicative of pulmonary hemorrhage within 3 months before registration
- No history of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess, bowel obstruction, or gastric outlet obstruction within 6 months prior to registration and complete healing/resolution prior to registration; no percutaneous endoscopic gastrostomy (PEG) tube placement within 3 months prior to registration
- No active peptic ulcer disease, within 28 days before registration
- No inflammatory bowel disease (including ulcerative colitis and Crohn's disease), diverticulitis, cholecystitis, symptomatic cholangitis or appendicitis within 28 days before registration
- No malabsorption syndrome within 28 days before registration
- No uncompensated hypothyroidism; patients with hypothyroidism on therapy are required to have thyroid stimulating hormone (TSH) within normal limits
- No radiologic or clinical evidence of pancreatitis
- No history of organ transplant
- Patients with active infection requiring systemic treatment within 28 days prior to registration are not eligible
Patients who are pregnant or nursing are not eligible; women of child bearing potential must have a negative serum or urine pregnancy test within 16 days prior to registration; women of child-bearing potential include:
- Any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy, bilateral tubal ligation or bilateral oophorectomy) or is not postmenopausal (defined as amenorrhea >= 12 consecutive months)
- Women on hormone replacement therapy (HRT) with documented serum follicle stimulating hormone (FSH) level > 35m IU/mL
- Women who are using oral, implanted or injectable contraceptive hormones or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy or practicing abstinence or where partner is sterile (e.g., vasectomy)
- Performance status: Eastern Cooperative Oncology Group (ECOG) 0-2
- Archival tissue must be available for submission, though it is optional for patients to choose to participate in the correlative sub studies
- Absolute neutrophil count (ANC) >= 1,500/uL
- Platelet count >= 100,000/uL
- Hemoglobin >= 9 g/dL; patients may not have had a transfusion within 7 days prior to screening assessment
- Total bilirubin =< 1.5 x upper limits of normal
- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x ULN
- Albumin >= 2.8 g/dL
- Serum creatinine =< 1.5 x ULN, OR calculated creatinine clearance >= 30 mL/minute (modified Cockcroft and Gault formula)
- Urine protein to creatinine (UPC) ratio < 1.0; if UPC >= 1, then a 24-hour urine protein must be assessed; eligible patients must have a 24-hour urine protein value < 1 g
- Total serum calcium < 12 mg/dL
- International normalized ratio (INR) =< 1.2 x ULN; subjects receiving anticoagulant therapy are eligible if their INR is stable and within the recommended range for the desired level of anticoagulation
- TSH within normal limits (WNL); TSH only required for patients on thyroid supplementation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01835158
Show 490 Study Locations
|Principal Investigator:
|Toni Choueiri
|Alliance for Clinical Trials in Oncology
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT01835158 History of Changes
|Other Study ID Numbers:
NCI-2013-00820 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
A031203 ( Other Identifier: Alliance for Clinical Trials in Oncology )
A031203 ( Other Identifier: CTEP )
U10CA180821 ( U.S. NIH Grant/Contract )
U10CA031946 ( U.S. NIH Grant/Contract )
|First Posted:
|April 18, 2013 Key Record Dates
|Last Update Posted:
|May 8, 2018
|Last Verified:
|November 2017
Additional relevant MeSH terms:
Carcinoma, Renal Cell
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Kidney Neoplasms
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Kidney Diseases
Urologic Diseases
Antineoplastic Agents
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors