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Tempest, The (US - BD RA)
Gabe washes ashore on a Hawaiian island with a vengeful Helen Mirren...
Prospera (Helen Mirren), the duchess of Milan, is usurped by her brother Antonio (Chris Cooper), and is cast off on a raft to die with her four-year-old daughter Miranda (portrayed in adulthood by Felicity Jones). They survive the experience, and find themselves stranded on a tropical island with the sole 'human' inhabitant, a deformed beast named Caliban (Djimon Hounsou). After initially befriending him, Prospera enslaves Caliban, then rescues and enslaves a powerful spirit named Ariel (Ben Whishaw), and claims the island as her own. 12 years later, Alonso (David Strathairn), the king of Naples, sails back to his kingdom from the marriage of his daughter to the prince of Tunisia, accompanied by his son Ferdinand (Reeve Carney), his brother Sebastian (Alan Cumming), his trusted counselor Gonzalo (Tom Conti) and Antonio. Prospera discovers their approach, and bids Ariel to create a violent tempest, wrecking the ship and stranding those aboard on her island.
The thing I like about Julie Taymor's films, especially her Shakespeare adaptations, is that they aren't afraid to be silly, or at least they can be read as purposefully silly. I suppose it's entirely possible that Taymor means every single over-the-top moment, and intends us to feel the melodrama, but this doesn't really matter to me since I can enjoy her wacky excesses. Shakespeare's writing, as I understand it, lends itself well to re-writing and re-contextualizing, and Titus, though flawed in its excess, was a fun mixed media, anachronistic approach to the material. It isn't as good as Kenneth Branagh's similarly embellished, and time adjusted (to something more consistent) Hamlet, but I find myself coming back to Titus more often than most Shakespearian motion pictures.
Taymor's second shot at Shakespeare, Tempest transcends period as Titus did, but not in such a blatant sense. No one plays videogames, rides motorcycles, or makes speeches on the steps of the Palazzo della Civiltà, but costumes and sets play with anachronistic elements. This makes for a less bold statement, but gives nice contrast and character to Taymor's strong sense of cinematic style. Her use of special effects is certainly faulty, though, and likely the most arrant weakness of the entire film. In this respect the cheese often gets the best of her, and she draws unfortunate comparisons to not very good music videos. The effects sequences based around Ariel the wind spirit, especially those that see him superimposed upon the frame, or awkwardly 'blended' into backgrounds, are kind of grotesque (even the ones that were apparently shot in camera). Scenes that are more heavily anchored in physical reality are much more successful, thanks in no small part to the eclectic and overwhelming organic beauty of Lanai, Hawaii. Taymor's films have always utilized natural, and man-made settings to marvelous effect, and in this film (along with Titus) she juxtaposes the normally stagy qualities of the original text with the majesty of authentic locations (Tarsem Singh did something similar with The Fall). When Taymor allows herself to delve to heavily into post-production heavy surrealism she doesn't only play havoc with the tone set by these more interesting, natural visuals, she also seems to be at war with her own goals for the film. She's like a special effects addict trying to create images that are in keeping with her style in only practical means, and like any addict she falls off the wagon a few times.
I assume that if I had a better understanding of, or at least a better knowledge base of Shakespeare I would have more critical things to say about this adaptation, but as someone entirely unfamiliar with this particular play (my grandfather was an English professor, and my ignorance concerning Shakespeare was a point of childhood protest for several years) I mostly enjoyed the manner in which this story is rolled out. It is explained in the extra features that the play can run upwards of four hours, and I appreciate the more condensed narrative, even though there's plenty of evidence of missing sequences. Even when condensed and somewhat rearranged Tempest has the strange rhythm of a stage play, which is a little off-putting, but unique, and usually interesting. I have a feeling the somewhat dull thud of the climax is inherit in the original work as well. The acting is quite well rounded, including a movie stealing turn from Djimon Hounsou as Caliban the deformed, plotting slave. Hounsou, who apparently has never worked with Shakespeare, revels in the physicality and language of the role. Helen Mirren, Tom Conti, Alan Cumming, David Strathairn and Chris Cooper don't overtly impress, but only because we've come to expect the best from all of them, and they aren't given anything as singular to work with. Ben Whishaw, Felicity Jones and Reeve Carney do quite well with relatively empty, cutesy, twee characters. Comedian Russell Brand is definitely out of place, but had he not been set against Hounsou and the always impeccable Alfred Molina I assume he'd look bad even if he'd been told to reign it in a bit.
So Disney isn't giving Tempest the biggest roll out, but they also aren't scrimping on this 1080p, 2.35:1 transfer. Taymor's intricately decorated vision lends itself well to the formats highly detailed capabilities, and sharp details are the transfer's greatest asset. There are a few minor edge haloes throughout, and some of the busiest wide shots occasionally feature a white blow-out or two, but on the whole the complex compositions are quite majestic. The use of natural lighting also leads to some inconsistencies in grain, and generally dark compositions. In close-up one can get lost in the incredible texture of the costumes (along with Djimon Hounsou's meticulous make-up), and in wide shot you can practically touch the moss covered rocks. The colour palette isn't excessive, but when colour is utilized it is rich and vibrant. Colour looks most impressive when Taymor utilizes natural environments. The mix of lush greens, cool blues, and eclectic earth hues are as lovely as any BBC nature documentary in your collection. The costumes, in turn, utilize a lot of blacks and reds, and are sharply separated from their natural surroundings with fine subtlety for the most part, though occasional elements, like Russell Brand's bright red scarf and sickly green suits, pop out more vigorously.
This disc's DTS-HD Master Audio 5.1 meets basic expectations, and is generally pretty modest. Taymor's favourite composer Elliot Goldenthal (who blew it right out of the park with Titus) once again embraces the delicious cheese factor of classic style heavy metal guitars and drums, and mixes them quite effectively with operatic strings and choruses. On other occasions he gets the job done with jazz and pop licks too. This score acts as a more constant representation of the film's aural dramas than sound effects, which are downplayed and mostly centered in favour of the Bard's dialogue. The aggressive drum tracks produce a nice, wide spread of LFE pumping fury. Ariel's antics, especially storms, create an occasional rush of surround and directionally enhanced effects, but for the most part the dialogue and music have precedent over very basic environmental ambience. Occasionally the dialogue falters a bit in volume or clarity due to capturing performances in the windy elements, but usually ADR matches rather effectively.
Going into Julie Taymor's solo director's commentary I feared that I would be wrapped up in her sometimes flowery, overly analytical language (I've watched most of the extras on her other releases, and listened to the Titus commentary), but was pleasantly greeted with a relatively down to business, easy to relate to track. Sure, Taymor can overwhelm with some of her theoretical and spiritual rhetoric, but for the most part this is an educational track, which explains the process behind filming such an ambitious movie on a modest budget, and gives those of us with less proclivity in reading Shakespeare a better understanding of the text. I also quite enjoyed her descriptive differenced between her version of the stage play, and this film adaptation. There's also a 'Shakespeare Experts' commentary track, which features 'renowned Shakespeare experts' Virginia Vaughn and Jonathan Bate. This track has definite educational value, but is so dry that listening to it is akin to sitting through a forced lecture. I fear that the people that will get the most joy from it, Shakespeare enthusiasts, will already know everything presented.
'Raising the Tempest' (66:10, HD) is a rather exhaustive look behind the making of the film, including interviews with writer/director Julie Taymor, producers Lynne Hendee, Jason K. Lau, Ron Bozman, production designer Mark Friedberg, assistant director Sean Guest, composer Elliot Goldenthal, costume designer Sandy Powell, make-up artist Richard Redlefsen, about a million other unnamed crew members, and actors Felicity Jones, Alfred Molina, Alan Cumming, Helen Mirren, David Strathairn, Tom Conti, and Russell Brand. The tone of this doc is pretty even tempered, but the interviews verge on brutally pretentious (the crew, not so much the cast). Every single freaking thing that went into this production was absolutely the most important, meaningful thing you could possibly imagine. I understand that everyone is trying to sell a hard sale, but I found myself positively exhausted any time I was presented with a talking head against a black background. Footage of people working is quite entertaining, though. Subject matter, which is not necessarily broken into sections, includes Taymore's stage play (including 1986 footage), the difficulties and advantages of shooting in the elements on Lanai, special effects, casting, rehearsals, changing the sex of the lead character, costume design, make-up design, music, and production design.
The disc also includes 'Russell Brand's Rehearsal Riff' (4:30, HD), a bit of rehearsal footage with the comedian, 'Julie & Cast: Inside the LA Rehearsals' (13:30, HD), more rehearsal footage with Brand, Molina and Hounsou, a 'Mistress Mine' music video, and trailers for other Disney releases.
Julie Taymor's adaptation of Shakespeare's The Tempest is a mixed bag of beautiful Hawaiian locations, strong performances, and unattractive, gaudy special effects. It's not the eclectic shot at the Bard's work Titus was, but it also avoids the heavy-handed visual metaphors of Across the Universe (a film I wanted to like, but kind of hated). This Blu-ray release (there's no official word on a DVD release yet) features an occasionally stunning transfer, a decent DTS-HD MA soundtrack, and a large collection of educational and entertaining extras, including a director's commentary, a Shakespeare experts commentary, and a hour-plus long behind the scenes documentary.
*Note: The images on this page are not representative of the Blu-ray image quality.
Review by Gabriel Powers
Chris Johnson Member Join Date: October 2005 Location: United States Posts: 1,465
I am a big fan of Shakespeare, but I am not sure if I want to see this as I absolutely hated "Titus".
David Blackwell Senior Member Join Date: February 2004 Location: United States Posts: 2,835
I liked The Tempest and loved Across The Universe. I had more love for the film version of The Tempest because I like Shakespeare adaptations on film (I hate Macbeth in its original form, but it excels as an Aussie gangster film).
Some material may be inappropriate for children under 13
Disc Details
Release Date: 13th September 2011
Discs: 1
Disc Type: Blu-ray Disc
RCE: No
Video: 1080p
Aspect: 2.35:1
Anamorphic: No
Colour: Yes
Audio: DTS-HD Master Audio 5.1 English, Dolby Digital 5.1 Spanish and Portuguese
Subtitles: English SDH, Spanish, Portuguese
Extras: Director Commentary, Shakespeare Experts Commentary, Raising the Tempest, Russell Brand's Rehearsal Riff, Julie & Cast: Inside the LA Rehearsals, Mistress Mine Music Video, Trailers
Easter Egg: No
Feature Details
Director: Julie Taymor
Cast: Helen Mirren, Djimon Hounsou, Alfred Molina, Russell Brand, Tom Conti, Alan Cumming, David Strathairn, Chris Cooper, Ben Whishaw, Felicity Jones, Reeve Carney
Genre: Drama and Fantasy
Length: 110 minutes
6Review Guide
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Gathering Basket
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- Summary
The functional design of this Paulownia wood-trimmed, antique-finished wire basket makes it a reliable companion at harvest time. Sturdy galvanized metal contains your fresh-picked fruits and vegetables while allowing escape for excess dirt and debris. The oblong container easily accommodates longer vegetables, fruits and foliage and can also be used to tote garden tools.
- Thick, arched Paulownia wood handle and sides.
- Lightweight yet durable.
- 19" x 10 1/2" x 7" high.
- Made in China.
- Use & Care
- Store indoors
- Shipping
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UPS can deliver most in-stock items within 3-5 business days. UPS is unable to deliver to P.O. boxes.
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For an additional charge of $26 per address, we can expedite delivery to most destinations. This service is not available for some oversize items, items shipped directly from the supplier (including perishable and custom-manufactured items), out-of-stock items and items to be shipped outside the contiguous 48 states.
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At Williams Sonoma, we take great pride in the quality and craftsmanship of our products. Attention to design, materials, safety and construction are our priority. Upon receipt, please inspect your purchase and notify us of any damage; we will arrange for a prompt replacement.
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Rated 5 out of 5 by YumYummy from Perfect for a small garden I bought this as a gift for someone that has a small vegetable garden every year. It is well made, large & not too heavy for an older person. I liked it & the recipient was tickled with it! Perfect!Date published: 2016-05-27Rated 2 out of 5 by Lepf from Cute basket but poorly made This is a very cute basket and I chose it for it's rustic look. The construction, however is poor. Both screws holding the wire into the wood side were missing on one side and it doesn't seem to be properly fitted even if the screws were there. Not decided wether to keep it and fix it or return it. It's a gift and I'm not sure I'd be happy to give a repaired purchase. Very disappointed.Date published: 2015-04-02Rated 5 out of 5 by CarolfromMN from Great gift! Last year I bought one for me and one for my Dad. We both love gardening. At eighty it's hard to find something he needs and loves. This was it! It came in handy all summer long for both of us!Date published: 2014-12-07Rated 5 out of 5 by OliSchwieb from Rustic & Functional While unfortunately I do not yet have a garden with which to use this wonderful basket, there is an endless amount of things you can do with it! Right now I'm storing hearty things like onions and potatoes in it on my open pantry rack in my kitchen! It looks great and is very functional. The construction is sound and it's a well made product which fits snugly over your arm if you are able to use it for actual gathering.Date published: 2014-10-19Rated 3 out of 5 by Rusure from Like the style, but..... When I opened the box, I was disappointed to find that two screws that held one of the sides on had pulled out of the wood end. I had to fix it before I could use it. It was not built with integrity, and I had expected better. This was my first Williams-Sonoma purchase, and it makes me hesitant to order again.Date published: 2014-07-02Rated 5 out of 5 by mrsrogers from Holds a bountiful harvest My new husband and I love to garden. This vintage gathering basket is larger than I expected, but I love it even more. I have had quite a few friends ask me where I found such an adorable garden basket...Williams Sonoma!Date published: 2013-08-03Rated 5 out of 5 by gardengirl91942 from Love this basket!! Huge basket, holds a ton of produce from my backyard garden. Super easy to spray down the vegetables, dirt washes away through the grates, less mess in my kitchen. Extremely sturdy, it looks like it will last forever. I use it to hold kindling for fires in the winter too!Date published: 2013-07-16Rated 5 out of 5 by Grammie4 from My Basket. Luv this basket. I should have bought more than One. It can be used for many things, indoors and outside. I use it mostly to gather things during the day to take to my downstairs bedroom at night.Date published: 2013-07-03


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False bomb threats force evacuations across Poland
WARSAW, Poland (AP) — Police detained one person Tuesday in connection with false e-mail bomb threats that led to the evacuation of hundreds of people from more than 20 hospitals, courts, police stations and prosecutors' offices across Poland, the interior minister said.
Bartlomiej Sienkiewicz said Poland's investigators were in touch with counterparts in the United States, France and Germany, because some of the e-mails were sent from servers in those countries. He refused to give any detail on the detained person.
Police who checked all the locations said that no explosives were found and there were no explosions at noon as the e-mails had threatened. One hospital in southern Poland was fully evacuated, one in Warsaw partially.
"The entire day was lost for us and for the patients," said Wlodzimierz Migacz, director of a hospital in Katowice, who ordered a full evacuation, including of a premature baby in an incubator.
"I hope the author of the e-mail will be found and punished," Migacz said on TVN24.
TVN24 footage showed ambulances leaving the hospital to take patients to other medical centers. In Warsaw, it showed some patients and relatives waiting in front of a hospital.
People were allowed to return to the buildings Tuesday afternoon.
Sienkiewicz said there was no danger to anybody's life or health and that the threats were a case of "unbelievable cheek" on an unprecedented scale.
A false bomb threat leading to major disruption carries a maximum prison sentence of eight years.


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Barthlemew Surname Ancestry Results
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As an artisan baker, Matthew Hickman refuses to compromise on the ingredients he uses or the age-old methods he employs.
As an artisan baker, Matthew Hickman refuses to compromise on the ingredients he uses or the age-old methods he employs.
"We make bread, literally, the way it was made 100 years ago," said Hickman, co-owner of Underground Baking Co. on Seventh Avenue in Hendersonville.
Hickman is among a handful of bakers in Western North Carolina devoted to using organic, regionally grown grains because, they say, it is a healthier option for their customers, supports a local economic cycle and represents a natural component of their craft.
"I think the artisan bread industry lends itself to using organic flour," said Dave Workman, owner of Flat Rock Village Bakery. "I think if you're an artisan baker, in general, you've got a more small-scale, healthy approach to it all that you would just choose to use organic flour, because we're spending a lot more time and energy on each individual loaf of bread than any grocery-store bread you'll find. It's really the only option for me."
Longtime baker Debi Thomas, owner of Wildflour Bakery in Saluda, called using organic wheat a "personal commitment," adding, "We wouldn't serve anything we wouldn't serve our own family."
Thomas and Workman are two of the more active members of Carolina Ground, a cooperative of WNC bakers whose micro milling facility in Asheville was designed to link Carolina grain growers with Carolina bakers. Project Coordinator Jennifer Lapidus, a 14-year bakery owner in Tennessee and Madison County, said she began spearheading the initiative in 2008 when the price of conventional wheat jumped more than 100 percent, causing a "train wreck" for bakers of higher prices and compromised quality.
Led by the work of David Marshal with the USDA Agricultural Research Service, Lapidus said, a natural breeding program had begun earlier in the decade to develop regionally adapted wheat varieties in the Carolinas, with the first crop from those initial trials released in 2008.
After securing a grant from the N.C. Tobacco Trust Fund, Lapidus was hired to lead the Carolina Farm Stewardship Association's N.C. Organic Bread Flour Project, a North Carolina L3C low-profit limited liability company that laid the groundwork for the construction of the Carolina Ground mill. Wheat serves as a great rotation crop in the state's tobacco fields, Lapidus said.
North Carolina has become the largest supplier of pastry wheat in the Southeast, so the agricultural and production side of the project was in place.
With the program's first full bounty of locally milled Carolina grains available this year, Lapidus' biggest challenge now is getting local bakers to buy into the program — and Workman and Thomas, who ended a 30-year practice of buying her chemical-free wheat from Montana to support Carolina Ground, stepped up to the plate. "I'm a big fan of both of them," Lapidus said, "because they've given me real commitments to this.
It's not an easy thing to do to shift your buying practices to support the local farming community."
Keeping it local
Hickman is not a member of Carolina Ground, but he said most of his wheat comes from North Carolina, Tennessee and Georgia, is shipped to a 100 percent organic North Carolina mill and then delivered weekly to Underground by a small distributor, thus supporting a local, micro-economic cycle.
It also ensures a betterquality product that Hickman insists on, he said, adding that supermodified, heavily sprayed conventional wheat has changed the crop for the worse during the past halfcentury. He thinks those changes have contributed to wheat allergies and bread-related digestive issues that have gained much attention in recent years. Hickman said the use of high-quality, all-organic wheat flour in his breads, pastries and Bavarianstyle soft pretzels — plus a traditional, slow (12-hour) fermentation of his breads that allows the natural enzymes in the wheat to break down hard-todigest proteins — results in a product that can be a healthy part of anyone's diet except those with severe gluten allergies.
"We're educating the public every single day," Hickman said. "I can't tell you how many times people will walk through that door and they have no idea what we do, and literally we explain to them our process, our breads, we have them sample our breads. It's really an ongoing process, and that's what a lot of consumers need right now. They want more information, and there's a lot of misinformation out there, especially when it comes to bread."
Workman agreed, saying his naturally leavened breads are much healthier than the store-bought variety with fresh, locally ground organic flour that retains essential nutrients.
Lapidus and local artisan bakers are hopeful that the soaring popularity of WNC tailgate markets in recent years is a clear sign of a "buy local" movement, in which consumers are becoming increasingly diligent in sourcing the food they put in their bodies, and that baked goods are as much a part of that as produce, honey and jellies, meat and dairy products.
Either way, Workman said he's committed to the core values that made him an artisan baker.
"As much care as I put into producing bread every day," he said, "any bakery like mine — like Matthew (Hickman's) — it's all about using the best ingredients and the best processes to deliver the best loaf of bread you can possibly make."


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NCGA Internet Web Site Management
(Adopted April 2000; Revised November 2008)
The North Carolina General Assembly (NCGA) publishes information about members of the NC Senate and House of Representatives on the NCGA Web site available at http://www.ncleg.net
The Principal Clerk of each chamber maintains information about their respective members. This information is used to create the web page for each legislator on the NCGA web site.
Legislator information which is available on the NCGA Web site includes: name, party affiliation, legislative office address and phone number, e-mail address, terms in House, terms in Senate, district, counties represented, occupation, and preferred district mailing address and phone number. There are also links on each legislator�s web page to his/her committee assignments and a list of bills he/she introduced or co-sponsored.
Legislator web pages may also include additional biographical information that is published in the North Carolina Manual biennially by the North Carolina Department of the Secretary of State. Each legislator must provide permission to publish his or her biographical information on the NCGA Web site.
Legislator information published on the NCGA Web site must follow the NCGA Internet Web Site Management policy adopted by the Legislative Services Commission.


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NEW YORK -- The NBA admitted Chauncey Billups' 3-pointer at the end of the third quarter of Monday's Detroit-Orlando playoff game should not have counted, but said referees weren't allowed to review instant replay to determine that.
League president Joel Litvin also said the disputed shot, which gave Detroit a 78-76 lead in its 100-93 victory, could not have been replayed after the clock malfunction was discovered.
"After reviewing the video of last night's Pistons-Magic game, we determined that the play that concluded with Chauncey Billups' 3-point field goal at the end of the third quarter took approximately 5.7 seconds," Litvin said in a statement. "Because there were only 5.1 seconds remaining in the quarter when the play began, the shot would not have counted had the clock continued to run."
Billups was bringing the ball up the court for the Pistons when the clock froze at 4.8 seconds because of a problem with the arena's timing system. After he made the shot, the game referees had to estimate how long the play took without the aid of replay because the league's rules don't allow for reviewing a play to determine when the clock started.
The league said the timekeeper who worked the game was from a "neutral" city, standard procedure for all games.
After the game, Orlando coach Stan Van Gundy said the referees indicated it took 4.6 seconds to complete the play. Lead official Steve Javie declined a postgame interview by a pool reporter.
"The referees followed proper procedure in addressing the clock malfunction by estimating the elapsed time and using their judgment as to whether the shot was taken in time," Litvin said. "Under NBA rules, the referees did not have the option of using instant replay and a timing device to determine exactly how much time had elapsed, nor do the rules allow for a re-play after a clock malfunction is discovered."
The NBA frequently talks about expanding the instant-replay capabilities for game officials, but this might finally get the league to act.
"The NBA Competition Committee was scheduled to discuss the possible expanded use of instant replay at its meeting at the end of the month and we will raise, for the Committee's consideration, the use of replay in situations like this," Litvin said.
Copyright 2008 by The Associated Press
Billups 3 pt Shot Should Not Have Counted
Talk about anything general in the NBA here.
Moderators: Mr. Crackerz, JREED, Guybrush, 32
I was not sure what to think of this play. It seemed to me that you cannot count the basket if the clock did not start, yet you cant replay it. It was definately a bad call, and most certainly helped in the Pistons' cause of winning that game.
EMan32 wrote:they should have replayed it on the spot. set the clock back to 5.1 or 5.2, whatever it was at, and just replay the whole play.
Yeah, cant see what the big problem is really, it happens all the time...........the clock doesnt work, the refs realise it at some point, stop play, and start again............total bull that they are not allowed to review and start again.


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Irish twins Shauna and Orla age 19 are identical except...
- by Alro23
- Rating:
- Published: 21 Jul 2014
- Updated: 21 Dec 2014
- Status: In Progress
My name is Haley White. I'm 20 years old. I live in an apartment in Dublin, Ireland. I attend a Cooking Collage. I have long brown hair, green eyes and I wear glasses or contacts. My best friend Lexi Wood lives across the hall from me and she attends a Beauty Collage, so she can become a beautician and open her own business. She has cherry red hair, blue eyes and has the cutest dimples I have ever seen. My live goal is to open my own bakery/café called the "Icing House". Lexi and my parents both live in Mullingar and are good friends. Ever since I went to a 5SOS concert with Lexi I've been having the same dream about the same boy I ran into. He had Blond hair (brown at the roots), blue dreamy eyes and the cutest Irish accent I ever heard even though I live in Ireland his voice makes me shiver with glee when I hear it in my dreams. It's being going on for a year now. This is where my story begins....
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Benedikt Howedes is staying - Schalke
Germany international Benedikt Howedes is not for sale, Schalke sporting executive Horst Heldt has insisted amid ongoing speculation that the central defender is interesting Manchester City.
Schalke skipper Howedes, 26, has been used as a left-back by Germany boss Joachim Low in the World Cup, playing every minute of their run to the final.
Sport Bild reported that his performances in Brazil have attracted the attention of City, and the paper said the Premier League champions were considering an offer.
But Heldt said: "There has been no official inquiry, and Benedikt is not for sale."
Howedes, under contract until 2017, has previously said he could consider a move abroad in 2016, and Heldt said: "It's always good to have a career plan, but 2016 is still far away. Maybe his plan next summer is to stay at Schalke forever."
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Mahd - Lotus (Covers Kanye & Jay Z's Otis) [Sound Management Submitted]
Detroit's own @iAmMAHD covers Otis. Download at iamMAHD.com.
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Linked by Thom Holwerda on Mon 24th Jan 2011 22:21 UTC
I just want to put up a little notice to inform you all about the lack of updates on the main page. The problem is that I've been hit by the flu and have been down and out since last Thursday, unable to do the news. The rest of the team has been occupied as well, so that explains that. I'm sorry for the inconvenience, and since I've pretty much almost recovered, normal posting schedule will resume either tomorrow or Wednesday at the latest. Thanks for understanding. Also, read more for the most beautiful piece of art ever created in the history of the universe. And I mean it.
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RE[2]: I believe Thom doesn't matter...
by SuperDaveOsbourne on Tue 25th Jan 2011 19:43 UTC in reply to "RE: I believe Thom doesn't matter..."
"I'm curious, why do you bother to read OSnews?"
Like many others in the world of 'news', we often like to document the train wrecks and carnage as they happen. Not all things in life are peachy and keen, factually news is really just olds that is marketed over and over again. OSNews is no exception, the wreckage as it happens is entertaining.


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Markle offices to move for handicap renovations
Monday, February 25, 2013 7:46 AM
Markle town offices must be moved out of their current building in order to make those offices handicap accessible.
One option for doing that, members of the Markle Town Council said at their Tuesday, Feb. 19, meeting is to move into the building currently occupied by the Markle Branch of the Huntington City-Township Public Library. The current library building is owned by the town of Markle.
While library board members have in the past expressed a desire to move to a different location, they're apparently in no hurry to do so.
The move of the town offices is prompted by the town's need to comply with the Americans with Disabilities Act (ADA), which requires that all facilities and programs be accessible by people with disabilities. The council has adopted an ADA transition plan, which calls for the town offices to be moved out of their current building.
Darren Goeglein of Goeglein Construction and Town General Assistant Mike Grant, who is serving as ADA coordinator, discussed the costs of adding on to the Markle Fire Station Building or constructing a new building on a lot adjacent to the fire station parking lot.
The new building could be occupied by the Markle Police Department and the clerk's office, but there would be no room for expansion.
Council also discussed using the current library building, which is owned by the town.
Council President Jeff Humbarger said he and Grant met with the board in 2012, at which time the library board was willing to discuss relocating to a larger structure. However, the library board wants to wait until spring to evaluate its options, Humbarger said.
Discussion of a new building for town offices will be continued in March.
A leaky roof on the library building is also a problem, Town Supervisor Rick Asher told the board. He presented several options for repairing the roof. Council agreed to hire 5-Star Roofing, of Hartford City, to install a new roof that will have a 20-year guarantee and increase energy efficiency in the building.
In other business:
• Duane Brumbaugh submittted his resignation as Markle's representative on the Huntington County Emergency Management Advisory Board. Grant was appointed to succeed him on the board.
• Rick DeLaney, representing the town attorney's office, submitted an employee handbook for review. Council members plan to review the handbook in March.


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The runaway Liga leaders travel to face Lucas Alcaraz's resurgent side hoping to add to their 12-point advantage over Atletico Madrid at the top of the table
Nyom, Lopez, Mainz, Siqueira
Recio, M Rico
Torje, Aranda, Nolito
Alves, Pique, Mascherano, Adriano
Thiago, Song, Fabregas
Pedro, Messi, Sanchez
Granada midfielder Dani Benitez will miss Saturday's Primera Division encounter against Barcelona after undergoing a hernia operation earlier in the week.
Fran Rico (knee) is also sidelined, but boss Lucas Alcaraz has a full squad to choose from otherwise.
Barcelona assistant coach Jordi Roura is likely rest some his stars ahead of the midweek Champions League trip to AC Milan.
Striker David Villa will not travel to Andalusia after being hospitalised with kidney stones, while playmaker Xavi (hamstring) is still out.
- Granada have won three of their last four matches in La Liga.
- The Andalusian outfit have lost their last three encounters against Barcelona by an aggregate score of 3-8.
- Granada have kept four clean sheets in their last five matches at Los Carmenes.
- Barcelona have won just one of their last four away matches in all competitions (W1, D2, L1).
- The Blaugrana boast the best attack in the Primera Division, with 78 goals scored in their 23 matches (3.3 goals per game).
- Lionel Messi (pictured, right) has scored eight goals in his last five Liga matches for Barca.


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AP source: Hall gets 1-year deal to stay in DC
WASHINGTON (AP) — Cornerback DeAngelo Hall is back with the Washington Redskins, agreeing to a more affordable one-year contract after being cut for salary cap reasons three weeks ago.
A person familiar with the deal said Monday night that Hall decided to return for approximately $2 million in 2013, a considerable drop-off from the $7.5 million in salary he would have made under his previous contract.
The person spoke under the condition of anonymity because the Redskins have not announced the deal.
Hall was a casualty of the Redskins' $36 million salary cap penalty imposed by the NFL for the way the team structured contracts during the 2010 uncapped season. The second half of the penalty kicked in this year, so Hall was released by coach Mike Shanahan on the eve of free agency so the Redskins could get under the cap.
Hall talked to other teams but couldn't find a better option than to stay where he was — albeit for considerably less money.
"The whole point of free agency is to test the market to see if anything's better out there," Hall told 106.7 the Fan. "I think Mike made it known that he wanted me to be a part of this football team. I made it known I wanted to be part of this team."
Hall, 29, had two years remaining on a burdensome, six-year, $54 million contract when he was cut. He said understood "the business side of things" that led the reigning NFC East champions to send him on his way. The cap penalty has been a contentious issue with the Redskins, who have called the sanction unfair.
"I felt like part of it was my fault. ... I felt like I owed it to these guys to give it all I've got for one more year," Hall said.
Hall's return creates a major shift in offseason priorities for the Redskins, who were in need of a new starting cornerback in addition to other needs — and with very little money to spend.
Shanahan has done a remarkable job to keep the team more or less intact by restructuring deals and by re-signing tight end Fred Davis and right tackle Tyler Polumbus to cap-friendly contracts.
Hall joined the Redskins during the 2008 season. He had four interceptions last year and has 39 in his nine-year NFL career.
Follow Joseph White on Twitter: http://twitter.com/JGWhiteAP


text:
Customer Reviews
All reviews are from people who have redeemed deals with this merchant.
What You'll Get
Choose from Three Options
$49.99 for a Springtime Buffet package ($157 value)
The Springtime Buffett package can be ordered online or picked up at any Omaha Steaks location. Find a store near you here.
- Four 5-ounce top sirloins
- Four boneless chicken breasts
- One 20-ounce package of all-beef meatballs
- Four 4-ounce Omaha Steaks burgers
- One 16-ounce package of Omaha Steakhouse fries
- Four 4-ounce caramel apple tartlets
- Omaha Steaks seasoning packet
$59.99 for an Easter Parade package ($182 value)
The Easter Parade package can be ordered online or picked up at any Omaha Steaks location. Find a store near you here.
- Four 9-ounce pork tenderloins
- Two 6.5-ounce trays of green beans
- Four 5-ounce pork and bacon burgers
- Four 4-ounce Omaha Steaks burgers
- Four 4.5-ounce chicken-fried steaks
- Four 5.75-ounce stuffed baked potatoes
- Four individual new york cheesecakes
- Omaha Steaks seasoning packet
$69.99 for a Feast for Easter package ($203 value)
The Feast for Easter package must be ordered online.
- One 2-pound boneless smoked ham
- One 2-pound oven-roasted turkey breast
- Four 4.5-ounce chicken-fried steaks
- Six 4-ounce Omaha Steaks burgers
- Two 12-ounce trays of green-bean casserole
- Two 12-ounce trays of roasted-garlic mashed potatoes
- Four individual carrot cakes
- Omaha Steaks seasoning packet
The Fine Print
Promotional value expires Apr 30, 2015. Amount paid never expires. Limit 3/person. 1/order. Valid only for option bought. Springtime Buffet & Easter Parade valid in-store or online. Other packages must be redeemed online. Must use promo value in 1 order. Extra $12 shipping fee. Doesn't ship to AK/HI/Canada/PR/USVI. Most orders ship 2-10 biz days from redemption. Must order by 3/29 for delivery by Easter. Does not ship to PO boxes or APO/FPO addresses. No substitutions. FINAL SALE; no returns unless defective. Voucher is non-transferable. Issued by Omaha Steaks Gift Cards. View full terms. Not valid w/ Promo Codes. Promo codes not valid on this offer. Merchant is solely responsible to purchasers for the care and quality of the advertised goods and services.
About Omaha Steaks
Founded in 1917, Omaha Steaks has spent nearly a century perfecting its delivery system. The company flash freezes its quality meats to keep them fresh and flavorful, and then the custom-cut pieces are slipped into individual vacuum-wrapped bags for added protection and convenience once it's time to start cooking. Lastly, the gift combos are nestled into coolers filled with dry ice and plenty of unsolved crossword puzzles before they're ready to begin their trip to your door. Upon arrival, the combos offer an array of mouthwatering proteins complemented by delicious side dishes and desserts, all perfectly preserved and ready for cooking.


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While a student at Owen High in Black Mountain, Tristan Stroupe was an accomplished athlete, playing football and baseball and competing in the shot put.
While a student at Owen High in Black Mountain, Tristan Stroupe was an accomplished athlete, playing football and baseball and competing in the shot put.
But by the time he was in his late 20s, married with three children, his weight topped 305 pounds and he "could hardly walk 100 yards without being out of breath." As a police officer at the Asheville Regional Airport, he knew his physical situation wasn't good for his job or his personal life, but like many others, he had trouble getting motivated to exercise and eat better.
That's when his best friend, Kevin Regala, stepped in. A Transportation Security Administration guard at the airport, Regala had started a CrossFit exercise program at Blue Ridge CrossFit in Fletcher and was feeling great. For months he pestered Stroupe to join in, until he finally relennted.
"Despite being the most out-of-shape individual there, I immediately fell in love with the constantly varied workouts, the Olympic lifting and the team and community aspect of CrossFit," Stroupe recalled. "After one year, I lost 70 pounds and I built my strength back up to weight-lifting personal records that I had achieved in high school."
Now, "I want to use my success to help others achieve their own personal goals," Stroupe said.
To do that, Stroupe and Regala have partnered to form GenX CrossFit in Flat Rock and offer "the next generation of fitness." Both men are certified CrossFit trainers.
"I have always had a love for fitness, but I have now realized that the day of joining the old-fashioned gym is over," Stroupe said. "A new day in fitness has dawned."
Regala couldn't agree more. Before discovering CrossFit, he tried so-called "old-fashioned gyms," and although "they can help you get in shape and make you healthier, after a friend introduced me to CrossFit, I realized this was by far the best way to be healthier and stronger."
Every CrossFit workout is different, Regala explained as he stood in the new 4,400-square-foot gym, which opened in mid-November. "It's constantly varied functional movements performed at high intensity."
The constant variety in workouts keeps gym members from becoming bored and dropping out, he said.
"The high intensity of the workouts means you can get results in a 20-minute workout that you can't get working out for an hour at a traditional gym," he added.
Members at GenX use specialized software to track their progress and plan future workouts, which Regala said helps members stick with the program. Another factor that helps them keep up the good work is a team atmosphere.
"Here we have a community that helps each other succeed and stay motivated. Instead of going to a gym where you do your workout on your own, here everyone does the same workout together," Regala said. "You can see that the person next to you isn't quitting, so it motivates you."
Although everyone does the same workout, "We tailor it to each person's needs and their individual fitness level. From teenagers to my 63-year-old mother, as long as someone's willing to put forth the effort, they can become healthier and stronger," Regala added.
As they guide the workouts, Regala and Stroupe include weighted medicine balls, kettle bells, free weights, rowers, ropes, gymnastic rings and rowers.
"We emphasize form and technique to minimize injuries," Regala said.
"We would rather someone lift 100 pounds the proper way than lift 400 pounds and hurt themselves," Stroupe said. Although all are welcome at GenX, "We are not here for athletes, but for people who go home after work and sit on the couch with a bag of chips and watch a movie. We want people who have never done a fitness program."
Because of CrossFit training, Stroupe said he has "become a better husband to my wife, Sara, and a better father to my three children. The other day my son's soccer coached wanted the parents to play. Before CrossFit, I might have said 'no, because Daddy's too fat.' But I said yes and I was able to run and run and run. My son said I was the best player out there."
Plus, he added with a smile, "I scored on the coach."
GenX CrossFit is located at 158 McCall St., off Tracy Grove Road in Flat Rock. For more information, call 828-231-4397 or visit www.genxcf.com.
Reach Tanker at 828-694-7871 or firstname.lastname@example.com.


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Hutch speaks at the Leaders Forum as part of London Games Festival If you missed the 11 day marathon celebrating art, culture and business of video games, don't worry! We've pulled together an overview of the key events from the week. It all kicked off with EGX Rezzed and closing on April …Read More »
Home / Tag Archives: Inside


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The Environmental and Energy Law Section has launched an initiative to green the legal
profession in New York State.
Since lawyers have made such a big contribution
to paperwork, hopefully we can lead the way to reducing it, and making the legal
industry more environmentally friendly. As a Section, we have continued to use
conference calls and web-based tools to put on programs, and to reduce paper
materials for meetings and CLEs by using CDs. Not only does this save on our
carbon footprint, but it enables members of our Section to attend programs for a
smaller investment of time and money. Led by our Pollution Prevention Committee
Co-Chairs Megan Brillault and Kristen Wilson, our plans include
encouraging New York law offices to enroll in the ABA-EPL Law Office Climate Challenge, and greening the
State Bar Association through the strategies our Section has already launched.
We also want to encourage changes to the state court system, including
electronic filing, as proposed in Green Justice: An Environmental Action Plan for the New York State
Court System, a 2008 report issued by Judge Kaye.
Contact Lisa Bataille for further information.


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|System: PS3*, Xbox 360
|Dev: Artdink
|Pub: Namco Bandai Games
|Release: January 28, 2014
|Players: 1 (2-8 Online)
|Screen Resolution: 480p-1080p
|Cartoon Violence, Comic Mischief, Mild Language, and Mild Suggestive Themes
The card system that comes from the games CCG origins was a welcome addition, for about an hour. After fiddling with cards endlessly after each mission, switching them from character to character and trying to make sure the best cards were equipped, I just got tired of it. Not to mention to get cards that were even the slightest bit decent you had to spend Premium Points, which could only be earned by delivering Energy Requests after missions. Though the amount of PP you get from Energy Requests does go up with time, it is still a long road to get any of the really primo cards. Of course, these are cards that would've probably been banned from decks in the CCG world, but we aren't playing a CCG are we? Are we?
Visually, Dragon Ball Z games haven't really evolved much in recent years. While the environment has become a little more crisp and clean, the character models look pretty much like they did back in the PS2 days – rigid corners, with thick black lines for edges and little detail to speak of. Of course they look better than they did in the PS2/Xbox days, but not by much. Many would attribute this to the "cell-shaded" style of the game, but I would attribute it to an apparent lack of caring about the future of the franchise. Progress is necessary. Though the visuals are wearing thin, I will say that the character models function well and control inputs directed my Saiyan (or Namekian, if you prefer) around the open arena as I saw fit, but at the sacrifice of odd camera angles.
One thing that Battle of Z does right, as many other DBZ games before it have, is having the actual voice cast from the show doing the voice-acting. Without this the game would have felt completely generic, so I was truly glad to hear my favorite characters as I knew them. But that's about where the success of the soundscape ends. While sound effects and score are done fairly well, they are extremely repetitive and become annoying quickly, which detract from their quality.
Overall, did I enjoy Dragon Ball Z: Battle of Z? Yes, I did. I know it might not have sounded like it, but I am an old-school fan and I'll never pass up a chance to kick Frieza's ass, no matter what form he's in. Some fans will be disappointed, as I was, but will deal with it because they want to play a game in the DBZ universe. Some fans will love it, simply because of the tons of characters available to play. But anyone who isn't a Dragon Ball Z fan already won't be made a fan by playing this game. If anything, it will turn them against DBZ, which is a very sad thing. One day, someone will make the DBZ game we all want. Who knows? Maybe it's you.
Joshua Bruce
Video Director
Date: January 31, 2014
Game Features:


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A criminal defense lawyer who said he met with Lindsay Lohan over the weekend has declined to take on her case – and cast the starlet as a confused princess-type.
"My impression of Lindsay is that she's a fragile lost child – a sleeping beauty with her head in the sand," Chicago-based attorney Stuart V. Goldbergtold People.
Goldberg said Lohan contacted him after her last lawyer, Shawn Chapman Holley, resigned without explanation last week in the wake of Lohan's 90-day jail sentence for violating the terms of her probation.
During a six-hour "heart to heart" at the actresses' West Hollywood apartment attended by Lohan, her mother Dina and younger sister Ali, the "Mean Girls" star did not "seem to have the awareness of what's going to befall her" but was "genuinely in pain," Goldberg said.
Lohan took notes during their conversation, while Ali asked "astute" questions, he said.
Goldberg said his advice that Lohan move away from Los Angeles, which he described as a "toxic environment," fell on deaf ears.
"She was like Teflon to that comment," he said. "It just slid right off her. She seemed to have some inner deep sadness that that was her fate."
While Lohan is apparently still in need of legal counsel, she's received a boost of emotional support lately from her ex-Samantha Ronson.
First, the celebrity DJ took Joan Rivers to task online Saturday after the gossip maven criticized Lohan on Twitter.
Then on Sunday, Lohan and Ronson were spotted dining out together at a sushi restaurant. The last time the pair made headlines Lohan allegedly lobbed a drink in Ronson's direction at a club.
Lohan is due to begin serving her jail sentence by July 20.


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|Episode Description
|Monday, May 20, 2013 - 7:00 AM
"Old and New In Harmony"
Roger replaces the existing concrete front walk with a beautiful new bluestone design. Tom shows Kevin the modifications he specified on the replacement windows. On the third floor, tile contractor Mark Ferrante uses a shower waterproofing system. D
|More on LEARN/CREATE (PT)
|No upcoming shows in database
|Previous on LEARN/CREATE (PT)
|No Past shows in database


text:
Linked by Thom Holwerda on Thu 23rd Aug 2012 14:00 UTC
For the first time in eons, Microsoft has changed its logo. "The logo has two components: the logotype and the symbol. For the logotype, we are using the Segoe font which is the same font we use in our products as well as our marketing communications. The symbol is important in a world of digital motion. The symbol's squares of color are intended to express the company's diverse portfolio of products." Nice logo, clean, concise. With Windows Phone 8, Office 2013 and Windows 8 on the way, the company could use a fresh coat of paint. Confusing that they're using what would've been a better Windows logo than the Windows 8 logo, but alas.
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RE[2]: What an awful try hard logo
by Chrispynutt on Fri 24th Aug 2012 14:38 UTC in reply to "RE: What an awful try hard logo"


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Designed to be size interchangeable with bronze bushings, Babbitt bearings and "DU" style bearings. Highly compact design for tight spaces with Frelon liners for high performance and long life. Bearings are available in many popular Imperial (Inch) sizes. Plain bearing design allows for simultaneous linear and rotary motion.
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Sivukartta Sivukartta
Web-sisällön esitys Web-sisällön esitys
Steven Matzner, Ph.D.
- Associate Professor, Biology
- Augustana University
- Postdoctoral Associate, Boyce Thompson Institute, Cornell University, Ithaca, N.Y.
- Ph.D., Ecology, University of California, Davis
- B.A., Biology, Augustana College
Current Research: Epigenetic regulation refers to modifications to the chromatin or DNA that can affect which genes are expressed. Epigenetic regulation has recently emerged as an additional layer of regulation acting at the interface between the genotype and the environment, creating phenotypes sensitive to environmental inputs. The overall goal of this research is to look at epigenetic regulation in known water-related genes and determine if water stress induced epigenetic alterations occur for these genes in tomato. Specifically, we have use the recently completed tomato genome sequence to identify genes that are likely to be under epigenetic control and are known to have an impact on wate use efficiency. Initially, we are looking to see if DNA methylation patterns are correlated with gene regulation changes in response to drought. Ultimately we will be looking at additional epigenetic mechanisms. With the threat of global warming and projections of higher drought frequency coupled with greater urban, recreational, and environmental demands on water resources; our need to understand how plants respond to their hydraulic environment has dramatically increased.
To visit Steven Matzner's website, click here.


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Effect of Filarial Infection on Immune Responses in Latent Tuberculosis
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01547884
Recruitment Status : Recruiting
First Posted : March 8, 2012
Last Update Posted : August 23, 2018
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
- Lymphatic filariasis is an infection that is caused by small, thread-like worms. It is spread by mosquitoes, and causes fever, chills, and headaches. If untreated, it can also cause elephantiasis, a condition that leads to swelling of the arms, legs, breasts, and scrotum. Treatment can eliminate the worms from the blood and reduce the risk of developing elephantiasis. Researchers want to study people with latent tuberculosis (TB) who may or may not be infected with filariasis. This study will look at the way that people with latent TB fight infection with these worms.
- To study how the immune systems of people with latent TB react to filarial infection.
- Individuals between 18 and 65 years of age who have latent TB and may or may not have filarial infection.
- Participants will be screened with a physical exam and medical history. They will provide a blood and stool sample to test for infection.
- Participants who do not have lymphatic filariasis but have another kind of intestinal worm will be treated for the parasite. This will be their last study visit.
- Participants who have latent TB and lymphatic filariasis will be treated with the standard treatment for the disease. They will come back for a second visit 6 months later, and will provide another blood sample.
|Condition or disease
|Tuberculosis Filariasis
Tissue-invasive helminth parasites infect close to 500 million people worldwide and are associated with strong T helper (Th)2 responses and regulatory networks that downregulate potentially protective Th1 responses. The two common tissue invasive helminth parasites are Wuchereria bancrofti, that causes lymphatic filariasis and Strongyloides stercoralis, that causes stronyloidiasis. Previous studies have shown that the intestinal helminth coinfection is accompanied by lowered in vitro production of interferon-gamma and elevated production of interleukin 10 in individuals with active pulmonary tuberculosis (TB). Our team has recently shown that co-existent filarial TB infections down-regulate Th1 and Th17 responses, which are necessary for protection against active TB.
The current study will compare immune responses to mycobacterial antigens in individuals with latent tuberculosis (LTBI+) and concomitant helminth infection (Hel+), including those with filarial (Fil+) and strongyloides (STR+) infection versus those with LTBI+ without concomitant helminth infection (Hel-). Immune responses to mycobacterial antigens from co-infected individuals will also be evaluated before and after treatment for helminth infection. Individuals (n=4000) will sign a screening consent prior to undergoing any study procedures. Every participant will have their medical history collected and will undergo a physical exam and a tuberculin 2TU purified protein derivative (PPD) skin test; women of childbearing potential will also undergo a urine pregnancy test, and those with positive test results will be excluded from the study. Individuals with positive PPD skin test results (> or = 5 mm) and no symptoms of active TB will have their blood drawn (5 mL) as part of the screening procedures to confirm LTBI+ status, evaluate circulating filarial antigenemia, determine Strongyloides status by ELISA, measure hematocrit levels, and for storage of serum samples; those with PPD skin test results less than or equal to 5 mm will be excluded from the study. Individuals with positive symptoms for TB will also be excluded from the study, but sputum will be collected from them, and those with positive smears will be referred for treatment. Individuals will be matched for age, gender, and geographic location, and they will be assigned to one of two groups, LTBI+ Hel+ (n=100) or LTBI+ Hel- (n=100).
Within 3 months of screening, individuals will be asked to sign an on-study consent and will undergo a second blood draw (10 mL) for immunological investigations and storage of serum samples; women of childbearing potential will undergo a repeat urine pregnancy test, and those with positive test results will be excluded from further study. Stool samples will also be collected for microscopic evaluation of ova and parasites. LTBI+ Fil+ individuals will be treated with a single standard dose of albendazole (400 mg) and single standard dose of diethylcarbamazine citrate (300 mg), which are available through the National Programme for the Elimination of Lymphatic Filariasis in India. LTBI+ STR+ individuals will be treated with a single standard dose of ivermectin (12mg) and a single standard dose of albendazole (400mg). These individuals will be asked to return 6 months after treatment to undergo a third blood draw (10 mL) for additional immunological investigations and storage of serum samples. LTBI+ Hel-individuals who test positive for other intestinal helminth infection will be treated with a single standard dose of albendazole (400 mg).
|Study Type :
|Estimated Enrollment :
|4000 participants
|Time Perspective:
|Official Title:
|Effect of Filarial Infection on Antigen-Specific Immune Responses in Latent Tuberculosis
|Study Start Date :
|February 7, 2012
- To compare the immune responses to mycobacterial antigens, including PPD and Mycobacterium tuberculosis culture filtrate protein, in individuals who are LTBI+ Fil- versus those who are LTBI+ Fil+.
- To compare immune responses to mycobacterial antigens in LTBI+Fil+ co-infected individuals, before and after treatment for filarialinfection.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Individuals (18 to 65 years of age) who meet the following criteria are eligible to participate in the study:
- Positive tuberculin PPD skin test result (>or equal to 5 mm) and IGRA+.
- Willingness to provide blood and stool samples for examination.
- Willingness to have samples stored for study participants only.
Individuals are not eligible to participate if:
- Pulmonary symptoms suggestive of TB (cough >3 weeks in duration and/or intermittent fever >1 week in duration and/or hemoptysis).
- Tuberculin skin test within the last 6 months prior to screening.
- Women who are pregnant or breastfeeding.
- Known documented cases of cancer, acquired immune deficiency syndrome, or other immunosuppressive illness.
- History of any other illness or condition which, in the investigator s judgment, may substantially increase the risk associated with the subject s participation in the protocol, or it may compromise the scientific objectives.
- Consumption of DEC in the last one year prior to screening.
- Pregnancy: Pregnant and lactating women will be excluded from the study because the safety of DEC or ivermectin has not been adequately evaluated during pregnancy or lactation, while albendazole is a Category C drug found to be teratogenic in animals, and it poses a potential risk during breastfeeding.
- EXCLUSION OF CHILDREN: Children (<18 years of age) will not be included in this study due to the fact the prevalence of filarial and strongyloides infection in children has been found to be very low in South India.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01547884
|Contact: Thomas B Nutman, M.D.
|(301) 496-5399
|United States, Maryland
|National Institute of Allergy and Infectious Diseases (NIAID), 9000 Rockville Pi
|Bethesda, Maryland, United States, 20892
|Principal Investigator:
|Thomas B Nutman, M.D.
|National Institute of Allergy and Infectious Diseases (NIAID)
|Responsible Party:
|National Institute of Allergy and Infectious Diseases (NIAID)
|ClinicalTrials.gov Identifier:
|NCT01547884 History of Changes
|Other Study ID Numbers:
|First Posted:
|March 8, 2012 Key Record Dates
|Last Update Posted:
|August 23, 2018
|Last Verified:
|August 20, 2018
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute of Allergy and Infectious Diseases (NIAID) ):
Immune Responses
Mycobacterial Antigens
Tissue-invasive Helminth Parasites
Additional relevant MeSH terms:
Latent Tuberculosis
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections
Spirurida Infections
Secernentea Infections
Nematode Infections
Parasitic Diseases


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Prop 4 Op-Ed in Detroit Free Press Ungrounded
In the Detroit Free Press recently, two opposing views about Proposal 4 — the home-based caregivers constitutional amendment — were published, but only one was factually correct.
The article opposing the union power grab was written by Robert and Patricia Haynes and laid out the position they have been forced into. The article in support of the proposal is from Dohn Hoyle, who is Prop 4 spokesman and executive director of The Arc Michigan (and last seen calling Robert Haynes an "idiot"). Hoyle's column is wrong on every single point raised.
Let's go through the points made by Hoyle:
"Proposal 4 ensures seniors and people with disabilities can direct their own care while remaining independent, safe and healthy in their own homes."
Already happening with the Home Help Program and nobody wants to stop this.
Stay Engaged
"It will help our loved ones who receive care in their own homes as an alternative to nursing homes."
Already happening and nobody wants to stop this.
"Importantly, Proposal 4 will ensure that those looking for care have access to a registry of home care workers who have undergone criminal background checks, an important safeguard to prevent neglect and abuse."
Already happening and nobody wants to stop this. Here is information about the registry.
"Proposal 4 will establish the Michigan Quality Home Care Council, which would oversee a registry that links home care recipients with prescreened home care providers in their area."
Already happening and nobody wants to stop this. Here it is online under a slightly different name.
"Home care providers on the registry will be required to undergo strict criminal background checks to ensure safety for seniors and people with disabilities."
Already happening and nobody wants to change this. Most of the disabled don't use the registry because at least 75 percent use family members or friends as caregivers.
The rest of the article reiterates the above points, platitudes or faux outrage.
So, every single thing Hoyle mentioned is already happening. But there is one important thing missing from Hoyle's column — the words "union" and "SEIU."
Since every reported dime to gather signatures and run this campaign are paid for by the Service Employees International Union, one wonders why it is not mentioned.
Proposal 4 is a power grab almost completely funded by a single entity trying to ensure the forced unionization it orchestrated that takes $6 million a year from the disabled and elderly in Michigan continues.
For $6 million a year and more than $32 million to date, a few million to force through a constitutional amendment isn't bad a bad return on investment — if the SEIU wins.
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Mackinac Center's Forfeiture Expertise Cited
Property Owner: Mackinaw City's Ban On Airbnb Rentals Violates Our Rights


text:
A BlankTV Premiere Presentation:
The Split Seconds - "Cutting Out"
Artist Bio:
Formed in 2015, The Split Seconds exploded onto the DC music scene with their unique style of no-frills classic pop-punk. Rising from the ashes of Dischord Records' The Coastals, frontman Drew Champion sought to put together a project combining the energy of late-70's Punk with undertones of 60's pop, and garage rock.
Joined by drummer Sean Peterson, bassist Stephen Parsons, and guitarist Alex Massi, The Split Seconds have brought their sound to enthusiastic audiences at DC-area punk clubs. The Split Seconds' self-titled LP was released in July 2016 to critical acclaim, featured on outlets including The Washington Post, Punknews, Dying Scene, New Noise, and Idobi Radio. In late 2016 The Split Seconds signed to Altercation Records, and will spend 2017 touring, recording, and performing at festivals including South by Southwest and The Antisocial Camp-Out.
>> Get music by The Split Seconds from Amazon and Altercation Records NOW! <<
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|Kyle Busch Wins ISM Connect 300
|Modified Season Sweep for Santos
|Bell Wins UNOH 175 Truck Series Race
|Mile Kyle: Busch Takes Pole for ISM Connect 300
|Short Track Extravaganza Set for Sept. 2018
|New England Themed Going Away Gift for Junior
Knoxville Welcomes Bayne Home with Open Arms
This East Tennessee city welcomed native son Trevor Bayne back into its soggy and wind-blown arms Monday afternoon.
It was a day on which the weather conditions couldn't have been much worse. Violent storms hammered the area, leaving much of it flooded. There were countless lightning strikes, hail and a report of at least one tornado. Still, hundreds of people made their way to the Knoxville Civic Coliseum, where they celebrated both a homecoming for Bayne and his improbable win in this year's Daytona 500.
This is not so much a sports town as it is a Tennessee Volunteers town, where most everything but the sky is bright orange. And as soon as Bayne flashed across the finish line at Daytona February 20, he became very much a part of the local lore in his hometown.
That kind of pride brought out folks like Robin Smith, who arrived in time to station herself and her family directly in front of the podium. They came early, she said with a smile dampened not in the least by the storms, "before the hail." Asked what could possibly bring her out on a day like this one, she replied very simply, "Trevor Bayne."
"He's just six months older than what my son is," Smith continued. "To see someone so young do such an awesome job ... that's something boys that age just dream about."
A few yards down from Smith was Evan Stone, who'd arrived three hours early to get a good spot. Next to him were Wendi Arnold and her nine-year-old son, David. This was a young man who'd been picked up early from school to attend the event.
David had no trouble putting Bayne's accomplishment into all kinds of perspective.
"Dale Earnhardt only won one Daytona 500, and Trevor's already done that," David quipped, with the shyest of smiles. Then, Wendi added, "Trevor is such a super guy, a good role model for kids. We wouldn't come see everybody. You hear him, and he's just got such a good outlook. I think it's a good thing for [David] to hear."
Bristol Motor Speedway hosted the rally, which was first moved from a downtown plaza due to demand and then indoors at the Coliseum because of the poor weather forecast. The track will offer a $100 "Bristol Bayne Backer" package which includes tickets to its upcoming March Sprint Cup and Nationwide Series events, a T-shirt and question-and-answer session with the driver.
"Man, that is the coolest race track we go to," Bayne grinned. "I used to, when I went to Bristol and they announced my name, I'd just hear crickets in the background every now and then. I'm pumped about it this year. If y'all want to scream your lungs out at Bristol, I would really appreciate it."
The homecoming began with a performance by Knoxville's Central High School Bobcat Company -- a choral ensemble and musical theatre troupe of which Bayne was a member during his freshman year of high school, just before he moved to North Carolina to pursue his racing dreams.
Then came the dignitaries. Bristol Motor Speedway General Manager and Executive Vice President Jerry Caldwell presented the driver with a custom-made, Bristol-themed skateboard. Knox County mayor Tim Burchett and Knoxville mayor Daniel T. Brown both proclaimed it Trevor Bayne Day. Condredge Holloway, who starred in the early 1970s at Tennessee as the first African-American quarterback in the history of the Southeastern Conference, gave the driver a UT football jersey with his name and number on the back.
After that, Len and Eddie Wood made their way to the podium. After Bayne wrecked in practice and the race itself just the day before in Phoenix, Len Wood couldn't resist whacking his young driver down to size a little bit.
"Winning the Daytona 500 really changed things for us," he said in earnest. "Trevor is such an amazing talent. He's got it going on in every direction ... but maybe not at Phoenix yet."
When Knoxville resident and master of ceremonies Dr. Jerry Punch opened the floor up for questions for NASCAR's newest superstar, a youngster asked Bayne if he had a favorite Bible verse. He does, and it speaks volumes on his outlook on Daytona ... and the disappointment of Phoenix.
"One that's really stuck out to me this week after Phoenix is Ecclesiastes 7:14," Bayne began. "It talks about being happy in the good times, but just know He made the bad ones as well. You've got to keep that [perspective] to maintain that mountaintop."
Since winning at Daytona, Bayne has been in a whirlwind of motion, traveling from one side of the country and back again for various media appearances. He got back from Phoenix Sunday night, and then headed straight for Knoxville. It was the first time he'd been back to his hometown since the victory.
His schedule has not allowed Bayne much time, if any, to sit back and reflect on the sheer weight of what he was able to do in Daytona. If nothing else, it was one confirmation for him to stay the course.
"Stay dedicated," Bayne said. "There were a lot of times when [bad] things were happening, and I'm like, 'What is going on here?' ... Don't count it as a sacrifice when these things are going on, because it's going to pay off. Whatever it is, whether it's playing football or driving race cars or singing or going to college, just stick with it. In the end, it pays off."


text:
Whooping cranes, the tallest of North American birds, stand nearly 5 feet tall. Their wingspan measures between 7 and 8 feet. Males weigh 16 pounds and females weigh 14 pounds.
Initially, chicks are the color of cinnamon brown. By four months of age the chicks have emerging white, adult-like feathers that produce a mottled appearance. Young whooping cranes achieve adult-looking plumage as they approach one year of age.
The average nesting territory for a pair of whooping cranes in Wood Buffalo National Park, located in Canada's Northwest Territory, is 1,013 acres.
The only remaining whooping crane natural population nests in Wood Buffalo National Park where the bird spends its summers. The whooping crane winters at the Aransas National Wildlife Refuge (NWR) on the Texas gulf coast. Whooping cranes were once found over most of North America - from the arctic to central Mexico and from the mid-Atlantic coast and New England to Utah, Wyoming, and New Mexico. A flock of non-migratory (resident) birds persisted in southwestern Louisiana until the late 1940s. The Fish and Wildlife Conservation Commission (FWC) has been involved with establishing non-migratory and migratory flocks of whooping cranes in Florida. Due to a number of problems, no further releases will be made into the non-migratory flock.
Whooping cranes rely on shallow marshes and adjacent, open grasslands.
Whooping cranes eat aquatic invertebrates (insects, crustaceans, and mollusks), small vertebrates (fish, reptiles, amphibians, birds, and mammals), roots, acorns, and berries.
The nesting season in Wood Buffalo National Park begins in late April or early May. In central Florida it begins in January and extends through May.
Mean clutch size, or number of eggs per nest, is 1.94 eggs. Most nests contain two eggs; occasionally, nests contain only one egg, and rarely three.
It takes between 29 and 31 days for the eggs to hatch. Both males and females incubate. A whooping crane pair will renest if the first clutch of eggs is destroyed before mid-incubation.
One chick is most common. Whooping cranes rarely succeed in raising two chicks.
Young whooping cranes are capable of flight when they are between 80- and 90-days old.
Young migratory whooping cranes become independent from their parents during northward migration or shortly after arrival on the breeding grounds. For non-migratory whooping cranes in Florida, young whooping cranes become independent just before the parents begin their next nesting season.
Whooping cranes produce their first fertile eggs between ages 4 and 7 (mean = 5.4 years).
Whooping cranes mate for life, but they will take a new mate after the loss of the original. The pair will return to use and defend the same nesting and wintering territory year after year.
They are known to live at least 22 years in the wild and perhaps as long as 40 years.
The world's whooping crane population has gradually increased from a low of 22 birds in 1941 to 503 birds in spring 2009. Always rare, the whooping crane population may never have exceeded 10,000.
During the nineteenth and early twentieth centuries, whooping crane habitat was lost to agriculture and drainage, and humans hunted the birds and collected their eggs - all of which contributed to the population decline. While Wood Buffalo National Park was established in 1922, it wasn't until 1955 that it was discovered that whooping cranes nested there. The Aransas National Wildlife Refuge (their principle wintering site), located in Texas, was established in 1937. Captive propagation, or breeding, initiated at the Patuxent Wildlife Research Center in Maryland in 1967 produced the first captive-produced eggs in 1975.
For whooping cranes to be "down-listed" from endangered to threatened status, there must be 40 nesting pairs in the Aransas/Wood Buffalo Park population and 25 nesting pairs in two additional locations, or 100 nesting pairs in the Aransas/Wood Buffalo Park population and 30 nesting pairs in one additional location. The migratory flock of whooping cranes in Florida is being introduced to achieve that goal.
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text:
I'm a few days into my Architect 2 trial and I've hit a problem that the samples have not solved.
I've a small block of code for theming a chart from your extjs tutorials (exhibit A). Now I'm not sure where this should live in the Architect world so I've added it to Application launch, on render event for my chart, etc. If I set the theme of my chart to Ext.chart.theme.Fancy or Fancy in the architect UI, the preview of the chart is not the desired effect (nothing really renders), and it goes on to tell me the object has no rendered. I've tried to peel back the onion on /src/chart/theme/Base.js but have not succeeded in getting any style other than the canned styles to effect my chart.
Question 1. Where is it appropriate to put the block of code to create a theme for a chart in the Architect 2 fashion? I've tried Application launch, on render event for the chart, etc.
Question 2. How do I apply the theme?
Question 3. What is wrong with the theme I listed below? From http://cdn.sencha.com/ext-4.1.1a-gpl...rts/Column2.js with a minor change to the color list for learning.
Exhibit A
Code:var colors = ['#CCCCCC', '#DDDDDD', '#BBBBBB', '#CCCCCC', '#CCCCCC']; var baseColor = '#eee'; Ext.define('Ext.chart.theme.Fancy', { extend: 'Ext.chart.theme.Base', constructor: function(config) { this.callParent([Ext.apply({ axis: { fill: baseColor, stroke: baseColor }, axisLabelLeft: { fill: baseColor }, axisLabelBottom: { fill: baseColor }, axisTitleLeft: { fill: baseColor }, axisTitleBottom: { fill: baseColor }, colors: colors }, config)]); } });


text:
Fan speed control
Template:I18n links start Template:I18n entry Template:I18n entry Template:I18n links end
Controlling the speed (and sound!) of your CPU fan is easy!
This can ruin your hardware. A CPU fan is needed to cool your CPU and in this howto it will be turned off for a couple of seconds. If you are not comfortable with doing this, don't!'
First, you need to set up lm-sensors. This is explained here
Once you have lm-sensors installed, you should have a readout with 'sensors'.
$ sensors w83627hf-isa-0290 Adapter: ISA adapter VCore 1: +1.14 V (min = +0.00 V, max = +4.08 V) VCore 2: +2.67 V (min = +0.00 V, max = +4.08 V) +3.3V: +3.39 V (min = +2.82 V, max = +3.79 V) +5V: +5.19 V (min = +3.47 V, max = +0.40 V) ALARM +12V: +12.40 V (min = +12.95 V, max = +7.96 V) ALARM -12V: -7.01 V (min = +1.78 V, max = -10.63 V) ALARM -5V: -3.84 V (min = -7.66 V, max = +2.29 V) V5SB: +5.75 V (min = +0.08 V, max = +0.54 V) ALARM VBat: +3.10 V (min = +0.54 V, max = +0.13 V) ALARM fan1: 2428 RPM (min = 0 RPM, div = 4) fan2: 0 RPM (min = 1630 RPM, div = 4) ALARM fan3: 2191 RPM (min = 6367 RPM, div = 4) ALARM temp1: +38°C (high = +20°C, hyst = +68°C) sensor = thermistor temp2: +39.5°C (high = +65°C, hyst = +60°C) sensor = diode temp3: +38.0°C (high = +65°C, hyst = +60°C) sensor = thermistor (beep) vid: +0.000 V (VRM Version 2.4) alarms: beep_enable: Sound alarm enabled''
If your output does not display an RPM for your CPU fan, and you are positive it is running, you need to increase the fan divisor. If your fan speed is shown and higher than 0, skip the next step. Increasing fan_div:
The first line of the sensors output is the chipset your motherboard uses to read the speeds/temps/voltages. Make a backup first: Code:
cp /etc/sensors.conf /etc/sensors.conf_original
Edit the /etc/sensors.conf file as root
nano /etc/sensors.conf
and look up your exact chipset. The names all look alike, so make sure the one you are editing is yours. Add the line fanX_div 4 near the start of your chipset config. Replace the X with the number of your CPU fan's, for me that was 2. You have to figure out for yourself which one it is, but it's probably 1, 2 or 3.
Save, and run:
sudo sensors -s
which will reload the sensors.conf's set variables. Run sensors again and check if there is an RPM readout. If not, increase the divisor to 8, 16 or 32. YMMV!
You can safely ignore anything that's not fanX_div. I would advise you to leave the other default settings as they are.
Once you have lm sensors properly configured, run pwmconfig to test and configure speed control of your fans:
Follow the instructions in pwmconfig to set up basic speeds.
The default configuration options should create a new file, /etc/fancontrol.
Follow the instructions in pwmconfig to set up speeds.
Second warning: Some of the steps outlined below describe how to tweak fan speeds. Before doing this be sure you have a low cpu load and are comfortable playing around. If at any time during tweaking you notice the CPU temperature start to rise dramatically, do a echo "255" > /sys/class/hwmon/hwmon0/device/pwm1 to spin up the fan all the way until things cool down. Basically, you should know what your doing before fooling with the configuration file
If your want more control, you probably will need to tweak the generated configuration in order get the results you expect. Here is a sample configuration file:
INTERVAL=10 FCTEMPS=hwmon0/device/pwm1=hwmon0/device/temp1_input FCFANS= hwmon0/device/pwm1=hwmon0/device/fan1_input MINTEMP=hwmon0/device/pwm1=20 MAXTEMP=hwmon0/device/pwm1=55 MINSTART=hwmon0/device/pwm1=150 MINSTOP=hwmon0/device/pwm1=105
- INTERVAL: how often the daemon should poll cpu temps and adjust fan speeds. Interval is in seconds.
The rest of the configuration file is split into (at least) two values per configuration option. Each configuration option first points to a PWM device which is written to which sets the fan speed. The second "field" is the actual value to set. This allows you to monitor and control multiple fans and temperatures (if your pc supports it).
- FCTEMPS: The temperature input device to read for cpu temperature. The above example corresponds to /sys/class/hwmon/hwmon0/device/temp1_input.
- FCFANS: The current fan speed, which can be read (like the temperature) in /sys/class/hwmon/hwmon0/device/fan1_input
- MINTEMP: The temperature (°C) at which to SHUT OFF the cpu fan. Efficicent CPU's often will not need a fan while idling. Be sure to set this to a temperature that you know is safe. Setting this to 0 is not reccommended, use a sane value.
- MAXTEMP: The temperature (°C) at which to spin the fan at it's MAXIMUM speed. This should be probably be set to perhaps 10 or 20 degrees (°C) below your CPU's critical/shutdown temperature. Setting it closer to MINTEMP will result in higher fan speeds overall.
- MINSTOP: The PWM value at which your fan stops spinning. Each fan is a little different. Power tweakers can cat different values (between 0 and 255) to /sys/class/hwmon/hwmon0/device/pwm1 and then watch the cpu fan. When it stops, use this value.
- MINSTART: The PWM value at which your fan starts to spin again. This is often a higher value than MINSTOP as more voltage is required to overcome inertia.
Try to run fancontrol:
It should start up and you'll probably hear your CPU fans spin down.
If it's working, in order to run at boot simply add "fancontrol" to DAEMONS in /etc/rc.conf, as a fancontrol init script is now provided by default!
Most of this howto is from [Ubuntu forums] and [Ubuntu guide].


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Betty White Rules The World: The Ultimate Guide To Television's Grande Dame
At 91 years young, it would be hard to find someone who is as hot, fierce, and fabulous as Ms. Betty White. Having been on TV since its inception, her career spans over nine decades. Betty has managed to go beyond her famous TV sitcom roles such as Sue Ann Nivens on the '70s "Mary Tyler Moore Show" and the adorable Rose Nyland in the '80s hit "The Golden Girls" to become an entertainment icon and advocate for animal rights.
I must admit, I am a huge "Golden Girls" fan. In fact, even though I own the DVDs, I still DVR the show and watch reruns on TV. I also read Rue McClanahan's autobiography and enjoyed it very much (you could say I'm a Rue McClanafan). My fingers were even crossed for a "Golden Girls" reunion movie until Estelle Getty passed away in 2008. That is why I was thrilled to be reviewing "Betty White Rules The World: The Ultimate and Unauthorized Guide to Television's Grande Dame!" by Mike Pingel.
Pingel's book about the fabulous Betty White is not so much an unauthorized biography but more a Betty White guidebook to her life written without White's authorization. Only a few of pages focus on White's childhood, a majority of the book covers her time in the spotlight. From her days on radio, to her time on game shows and sitcoms, to the Facebook campaign that led to her hosting SNL, to her current TV hit, "Hot in Cleveland," Pinglel discusses her entire career while touching upon her personal life.
At times, it seems the author does not add anything to what could be found on Ms. White's Wikipedia page. He does add gems such as an outline of supposed feuds she has had in Hollywood, as well as a timeline of her hairdos, and my personal favorite, Betty White drinking games.
Pingel includes interviews with other passionate fans, including Andrew Zubko, who painted a picture of Betty White holding a chainsaw while riding John Ritter as a centaur. He also interviewed Kevin Fabian who plays Rose in the "Golden Gays," as well as Chris Gaida, a professional celebrity walker who has walked beside Betty.
A fascinating part of the book comes when Pingel interviews Jim Colucci, author of "The Q Guide to the Golden Girls." Colucci interviewed the Golden Girl while researching his book. In reference to Betty's interview, he states that "Betty was perfect. She did not disappoint."
Although Pingel has credible sources, the guidebook leaves reader wanting to hear Betty White in her own words.
Betty White Rules The World: The Ultimate and Unauthorized Guide to Television's Grande Dame!
Mike Pingel
Angelic Heaven Publishing