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"Karaoke" is the brand new single, still warm out of the oven by the electric New York duo Fly by Midnight. They bring us an amazing indie pop song that will surely get you to stand up and shake your body. Plus you also get a chance to get to know them better below
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Short Interview with the guys
Why Fly By Midnight?
Slavo: Whether it be the studio, a live performance, or a night off with friends, Justin and I always find ourselves doing something music related by the time midnight rolls around. Not really sure where the fly part came from cause we're pretty normal dudes… I give you Fly By Midnight 🙂
What inspired "Karaoke"?
Justin: Karaoke started from one lyric written in my phone in the midst of a dorm room party in NY. From there we wrote about the rest of that night & the monumental feeling of being at your first college party.
What to expect for the future?
Justin: More music, more shows, more opportunities to create fans around the world.
Slavo: More Fly By Midnight songs to sing at your local Karaoke bar. (See what I did there?)
Justin: *laughs*


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Emergency Help Fund
Without the help of rescues such as Animatch, the lives of dogs like Sunshine would no doubt be shortened. She has a humongous bladder stone, rotten teeth, and cloudy eyes and the first two need immediate care. We are asking our supporters to come through for Sunshine. After all, she has only you to count on.Donate Online Now
In order to continue to help other dogs have the same chance as Sunshine, Animatch must replenish our emergency fund. All donation over 25$ will receive a tax receipt.
Animatch Walk-A-Thon
Join our Animatch adoptees, their families and friends at the Civic Center in DDO for a day of fun and fundraising! If you can't make it, please consider making a donation here.
Download the Pledge Form
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Next Meet and Greet
Come meet our dogs at our upcoming Meets & Greets!
Mon Ami
100 du Barry, Kirkland
From 11:30 - 2:30
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Mon Ami
100 du Barry, Kirkland
From 6:00 - 8:00
Finnegan's Market
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subset: commoncrawl


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They always say bigger is better. When 6 dozen shag balls isn't enough, double up your ice cold practice with the Jones XL Ranger. Featuring heavy-duty dual handles to account for the additional capacity, external zippered pocket for secured storage, and heavy-duty D-rings to hang a bottle opener or Bluetooth speaker. The XL Ranger is perfect for a unique gift or tailored tee prize. Personalize your practice by customizing your XL Ranger with a Jones logo, nicknames, or company logo.
- Materials: 1260 Nylon, Jones Vinyl, Insulated Liner
- 16"Tall x 9" Wide
- Comfortably fits 12 cold beverages
- Weight: 3.5 lbs


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In Saturday night's Republican debate, Chris Christie claimed raising taxes on millionaires cost New Jersey $70 billion. Is he right?
Well, maybe. But maybe not.
In 2004, then–New Jersey Gov. Jim McGreevey signed legislation that added a 8.97 percent tax increase on income of more than $500,000, a surcharge that was quickly dubbed "the millionaires tax."
Then what happened? It depends who you ask.
In 2010, the Center on Wealth and Philanthropy at Boston College released a report studying the movement of wealthy households to and from New Jersey. It concluded that wealthy people did consider the tax when deciding whether to move to or remain in New Jersey. According to its data-crunching, from 1999 to 2003, there was "a net influx of $98 billion (in 2009 dollars) in household wealth." Most of those people came from the neighboring states of New York and Pennsylvania. After the tax was implemented, the well-to-do families that left the state were less likely to be replaced by high-earning households. The study's authors calculated this resulted in a loss of $70 billion in wealth.
Case closed? Not so fast. The following year, Cristobal Young, a professor of sociology at Stanford, and Charles Varner, then a doctoral student at New Jersey's Princeton University (he's now affiliated with Stanford's Center on Poverty and Inequality) released a study comparing households subject to the new tax with those earning between $200,000 and $500,000—people who were prosperous but not quite rich enough to get hit by the millionaires tax. They found little difference in relocation rates between the two groups.
But you can't keep a good myth down. In 2014, RegentAtlantic Capital, a New Jersey–based financial advisory firm, released a study claiming to show that "New Jersey residents who are already considering moving to another state often solidify their decision when they realize the amount they can save in taxes." The proof, however, was less than convincing.
The 2014 survey showed households moving within New Jersey earned "about 50% less" than the ones relocating to lower-taxed Florida and neighboring Pennsylvania. One problem: The households moving from New Jersey to Florida were earning an average of $74,000—not even close to enough to be subject to the millionaires tax. Even the survey's authors concluded, "Tax migration may currently be more of a threat than an actual problem."
Earlier this year, Phoenix Marketing International, a market research firm, released a study showing New Jersey lost 10,000 millionaire households in 2015. While the study's lead researcher claimed in an interview that he believed the state's tax rate led some people to relocate from New Jersey to other states, he offered no proof.
In fact, any number of things could be going on in New Jersey. The moves might reflect a natural tendency of older residents to move to places like Florida. As Young and Varner pointed out, Florida doesn't have a state tax, but taxes are also low in Texas, Tennessee, and New Hampshire. What does Florida have that no other state does? If you're thinking Miami and Palm Beach, well, so were they. "It is difficult to know whether the Florida effect is driven by tax avoidance, unique geography or some especially appealing combination of the two," they wrote.
The change in New Jersey's appeal could also indicate the changing residential preferences of generation X and millennials, who are lingering in cities longer than their parents did. That's been documented in New York's Westchester, Nassau, and Suffolk counties, bedroom communities that are struggling to keep and attract younger residents.
Finally, it could even mean people in New Jersey do want to pay lower taxes. But the proof for that is less than robust—despite what Chris Christie claims.


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Daniel Apai: The University of Arizona
Extrasolar Storms: Cloud Physics and Atmospheric Dynamics in Brown Dwarfs and Exoplanets
Observations of directly imaged and transiting exoplanets, and brown dwarfs reveal the wide-spread presence of condensate clouds. These clouds profoundly influence the energy transport through ultracool atmospheres and impact their pressure-temperature profiles. Yet, the structure and properties of these cloud layers remain mostly unknown and pose one of the great challenges in understanding ultracool atmospheres. I will show how HST's unique stability and sensitivity allow us to address this challenge via an exciting new observational approach. With time-resolved spectroscopy and photometry -- rotational phase mapping — we are exploring the longitudinal structure of clouds; with multiple epoch observations we are following the evolution of the cloud cover, opening a new window of atmospheric dynamics. With the powerful combination of simultaneous HST and Spitzer observations we are exploring the vertical structure of the atmospheres, revealing multiple cloud layers. Finally, I will also show how the combination of JWST and HST will allow us to push this technique to new heights - and probe new depths and new physics in ultracool atmospheres.


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In the first episode of Tes Podagogy - the Tes podcast all about teaching and learning – Daisy Christodoulou, author of Seven Myths About Education and Making Good Progress – explains why assessment is important, how teachers can do it better and why it's much more interesting than some would have you believe.
Join Sarah Simons and Stephen Exley for a discussion about the week's big issues in FE. Including: why hundreds of SEND students are in limbo over whether they will start college next month; the private equity firm stumping up £135k to support disadvantaged college students; and the college which has put WorldSkills at the heart of its curriculum.
In this week's podcast Stephen Exley talks to Sarah Simons about how colleges are being forced to ditch A levels due to funding pressures. An exclusive survey, carried out by the Association of Colleges in partnership with Tes, reveals that 60 per cent of colleges offering A levels have had to cut back on the number of subjects available to their students. Stephen and Sarah also chat about one of the great characteristics of FE – its diversity – and how it needs to be maintained in a post-Brexit world, as well as how UTCs are a great idea (in theory) but, all too often, struggle in practice, and the importance of CPD in the FE sector.
This week the Tes FE News team discuss the thorny issue of principals' salaries. Government figures reveal that in 2015-16 almost 60 per cent of colleges increased spending on principals' and CEOs' salaries, while their staff experienced a national pay freeze. The team also talk about the bromance between apprenticeships and skills minister Robert Halfon and his opposite number, Gordon Marsden, and explain to listeners what an apprenticeship really is.
Stonewall is a charity which works to achieve equality and justice for lesbians, gay men and bisexual people. In this episode of the TES FE Podcast, Sarah Simons talks to Hannah Kibridge of Stonewall about how to combat homophobic language and celebrate diversity in colleges.
In this Christmas episode of the TES FE Podcast Sarah Simons chats with Reverend Kate Bottley. As well as being an Anglican priest, mum, wife and star of Channel 4's Gogglebox, Reverend Kate is the chaplain of an FE college. Here she discusses support for students, vulnerability & giving out gorillas.
In this Ofsted special of the TES FE Podcast, our very own Sarah Simons is in conversation with Lorna Fitzjohn, Ofsted's Director of FE & Skills, asking questions sent in by education professionals from all around the UK.
In this episode, Sarah Simons learns about the FE and skills system in Brazil from the Association of Colleges' International Manager, Ayesha Williams. Sarah also talks to two FE leaders who have embarked on an international shadowing project, Peter Mayhew-Smith, Principal of Kingston and Carshalton College and his counterpart, Patterson Patricio de Souza, a Professor and Director from a large college in the state of Minas Gerais, in Brazil.
In this episode of The TES FE Podcast our very own Sarah Simons is joined by Tony Payne of Canterbury College, just as he came off stage at the AoC Conference after collecting the College's Beacon Award. Sarah's second guest is President of the National Union of Students, Toni Pearce who discusses the value of learner voice in helping colleges become relevant and responsive to local communities.
This episode of the TES FE Podcast was recorded at the Association of Colleges' Conference, where Sarah Simons spoke to Richard Atkins, President of the AoC and Principal of Exeter College about the organisation's manifesto, plus new ideas for careers hubs and transport.


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Dance The Fright Away Draculaura
Dance The Fright Away Draculaura is a dress up game to play online at Snowwhitegames.Com. You can play Dance The Fright Away Draculaura in your browser and your mobile for free. In this game, the students of Monster High unite to revel in the opening of the iconic high school, and the ghouls are wearing their beast for the celebration! Draculaura, daughter of Dracula, is flawesome in a party dress with metallic details, fancy shimmer and glam ghoul makeup. Enjoy game! Use the mouse to play this game.


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A wheelchair can be a lifeline if you are living with a
long term disability.
We'll make sure you can access the right equipment for
you, so you can be as independent as possible.
Our team of specialists work with children and adults in a
number of locations; at home, in care homes, in clinics and in
Swindon Intermediate Care Centre.
The team is made up of dedicated physiotherapists and
occupational therapists who complete a comprehensive assessment of
your needs.
If you'd like to know how the Swindon Wheelchair and
Specialist Seating Service can help you, contact your GP for a
Or if you wish to contact us directly call 0303
333 1460
If you only want to use a wheelchair temporarily or
occasionally, please contact the Red Cross on 01793
Please contact us at firstname.lastname@example.com and we'll put it right.
© 2019 Great Western Hospitals NHS Foundation Trust
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Homeschool Success by Susan Higgins
Our first year of homeschooling met with success for both my husband and I as parents and for our little pupil. She learned to read, which is always amazing to me; seeing that light turn on as they finally "get it." She learned how to add and subtract 2-digit numerals which I don't think I did until the end of second grade. And she's learning how to be curious and find out what excites her, which is the real goal, I think. As Yeats said, "Education is not the filling of a pail but the lighting of a fire."
We get a lot of questions on homeschooling whenever we see our non-homeschooling friends and family. As much as I hate being the poster-family for homeschooling, I try and remember that their curiosity comes from a good place and be patient with them. Most people want to know what "curriculum" we use. I put it in quotes because a lot of people seem to think that we are required to follow a specific curriculum. In NJ you do not. NJ requires that all children between 6 and 16 receive a public education or its equivalent. That's it. If the school system feels that you are not providing that to your children, they can bring you to court. Once you show what you are providing your child, in terms of education, the onus is on the school system to prove it's not equivalent. This has not been done very often, but it's enough of a concern that I keep a record of what we've covered in a teacher's planning calendar.
We are primarily following a classical education format called a Trivium. It's based on a solid foundation of grammer, logic and rhetoric. At age 7, this means a good foundation in reading skills, with the idea that it will open up doors for her to learn about, well about anything she wants. We also have a strong focus on math and include several hours a week for history, art, music and sports. Another popular homeschooling style is called "unschooling," meaning that there is no set instruction. Children learn as they go about the course of the day or as things interest them. Writing thank you notes is a lesson in writing, grammar, penmanship and manners. A trip to the farmer's market can be a math lesson, etc. Another popular type is called unit-based learning. The child and parents find something of interest: Egyptian pyramids, the solar system, the rain forest and use that subject as a spring board for learning math, reading, writing, etc as they learn about it.
There are many different schools of thought on homeschooling and from parents I've talked to in-person and online, no one style is perfect for everyone. Some parents even tailor the style to how the child learns best, not something they're likely to learn in a public school, with its one-size-fits-all curriculum. Montessori and Waldorf adherents both have homeschool versions. There are Christian and other faith-based homeschool philosophies. Also, for parents who want to, there are distance learning and correspondence curriculum for purchase. I know one family who uses an online school. The kids "meet" with their teachers online every day.
Lucky for us, there is an abundance of information on homeschooling out there. Not the case for anyone who was teaching at home twenty or even ten years ago. And the internet has made sharing this information easy and much of it free. Some resources that we've used:
Homeschool Your Child for Free, LauraMaery Gold and Joan M. Zielinski, a comprehensive resource guide for finding free information on the internet, from curriculum planning to organization help.
www.bbc.co.uk/schools has the entire British schools curriculum online and I find it much more entertaining and user-friendly than many American sites. We're using it this year for Ancient Greek history. It has games and interactive lessons for kids.
www.homeschooldiner.com a fun blog with a lot of information about the various types of homeschoolers.


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Septins form a subfamily of highly related GTP‐binding proteins conserved from eukaryotic protists to mammals. In most cases, septins function in close association with cell membranes and the actin and microtubule cytoskeleton to regulate a wide variety of key cellular processes. Further underscoring their importance, septin abnormalities are associated with several human diseases. Remarkably, septins have the ability to polymerize into assemblies of different sizes in vitro and in vivo. In cells, these structures act in the formation of diffusion barriers and scaffolds that maintain subcellular polarity. Here, we focus on the emerging roles of vertebrate septins in ciliogenesis, neurogenesis, tumorigenesis and host–pathogen interactions, and discuss whether unifying themes underlie the molecular function of septins in health and disease.
Cells contain a complex mixture of macromolecules. How order is established and maintained in cells remains a tantalizing question. A central strategy of eukaryotes seems to be the compartmentalization of cellular spaces—for example, through membrane encapsulation of organelles. Two additional layers of compartmentalization have become evident over the years. Scaffolding platforms, such as centrioles, provide a recruitment surface for the localized integration of signalling processes and anchorage of cytoskeletal structures. Lateral diffusion barriers, on the other hand, promote the compartmentalization of the plane of membranes into distinct domains. These barriers slow down the diffusion of membrane‐associated molecules over boundaries and also act as scaffolding platforms. Increasing evidence suggests that such barriers are highly conserved among organisms, and are involved in the function of numerous cellular structures and appendages.
At the molecular level, a class of P‐loop GTPase proteins—the septins—has been recurrently associated with lateral diffusion barriers. With the exception of land plants, septin genes are found in all eukaryotes. A group of related genes—the paraseptins—are also found in prokaryotes. The number of septin genes varies greatly between organisms: Homo sapiens has 13, the nematode Caenorhabditis elegans has only two and the budding yeast Saccharomyces cerevisiae has seven. Further complexity is added in many organisms by alternative splicing (Cao et al, 2007; Pan et al, 2007). Septins show a marked ability to oligomerize into hetero‐complexes, which in turn polymerize into large assemblies composed of paired septin filaments (Bertin et al, 2008; DeMay et al, 2011; Sellin et al, 2011; Sirajuddin et al, 2007). On the basis of sequence homology, the 13 human septins can be divided into four subgroups (Table 1; Kinoshita, 2003). In cells, they form stable 6–8‐subunit complexes containing members of at least three subgroups (II, VI and VII), with the 8‐subunit complexes being marked by the presence of subgroup III septins (Table 1; Sellin et al, 2011). At least in yeast, the ability to from filaments is crucial for the function of septins (McMurray et al, 2011). Unlike actin filaments and microtubules, however, neither the septin complexes nor septin filaments are polar (Sirajuddin et al, 2007; John et al, 2007).
In cells, higher‐order septin ring‐like structures are found at the base of cilia, flagella, dendritic spines and yeast buds, where they associate tightly with the plasma membrane and recruit other molecules (the 'septin ring' paradigm, shown in Fig 1). Thereby septins mediate the formation of a lateral diffusion barrier in the membrane with which they have contact, and compartmentalize the membrane into two domains. The septin rings also act as cortical organizers for the actin and microtubule cytoskeleton. In yeast, the septin ring can exist in a 'frozen' state, in which subunits do not exchange, and in a 'fluid' state, in which subunits are rapidly exchanged (Dobbelaere et al 2003; Caviston et al, 2003). However, recent fluorescence intensity measurements suggested that septins are constantly, but slowly, recruited to the ring, until the ring splits (Chen et al, 2011). During bud growth and cytokinesis, the septin ring is in its frozen state, transiting through the fluid state only briefly during ring formation and splitting. During ring splitting, the filaments reorient 90° in a switch‐like manner from parallel to perpendicular relative to the mother–bud axis (Vrabioiu & Mitchison, 2006; DeMay et al, 2011). However, the dynamics and orientation of septins in metazoan rings are not known (Fig 1C).
This septin‐ring‐dependent mechanism of cellular compartmentalization was first described in yeast (Barral et al, 2000; Takizawa et al, 2000). The more recent finding that septin‐dependent cellular compartmentalization has important roles in the structure and function of cilia, flagella and dendritic spines in metazoans might explain why septin abnormalities are linked to a variety of diseases, such as Alzheimer and Parkinson, schizophrenia, cancer, infertility and pathogen infection (Connolly et al, 2011b; Mostowy & Cossart, 2011; Toure et al, 2011; Peterson & Petty, 2010; Hall & Russell, 2004). Several recent reviews give a comprehensive view on septin biology and the structural and biochemical aspects of septin complexes (Cao et al, 2009; Caudron & Barral, 2009; Gilden & Krummel, 2010; Gladfelter, 2010; McMurray & Thorner, 2009; Spiliotis, 2010; Weirich et al, 2008). Here, we focus our attention on the emerging roles of animal septins and their adaptation to novel functions during the evolution of multicellularity.
Septins in the formation and maintenance of cilia
One of the best examples of how the septin ring paradigm (Fig 1) is conserved in higher eukaryotes comes from cilia, at the base of which septins form a ring‐like structure. Cilia and flagella (hereafter referred to as 'cilia') are ancient organelles involved in generating movement and in sensing and transducing extracellular signals such as morphogens, odours, light and mechanical stress into the cell (Berbari et al, 2009). Their core structure, called an 'axoneme', is composed of nine cylindrically arranged microtubule pairs (9 + 0 in primary cilia), accompanied by one central microtubule pair in motile cilia (9 + 2). This axoneme arises from the distal end of the mother centriole, known as the 'basal body' (Figs 1A, 2A). During ciliogenesis, Golgi‐derived vesicles are targeted to the distal pole of the basal body to form the ciliary membrane, which is anchored to the basal body by a set of microtubules called the transition fibres (Rohatgi & Snell, 2010; Sorokin, 1962). The elongation of cilia occurs through IFT‐mediated delivery of structural subunits to the tip of the axoneme. This growth eventually leads to the fusion of the ciliary membrane with the plasma membrane and the emergence of the cilium from the surface of the cell (Rohatgi & Snell, 2010).
Although continuous with the plasma membrane, the ciliary membrane is insulated from it, with a distinct molecular composition adapted to its functions. Interestingly, septins assemble in a ring‐like array at the base of both the motile cilia of frog embryos (Kim et al, 2010) and the primary cilia of mammalian cells (Hu et al, 2010). In both cases, reduction of septin expression causes a reduction in the number of cilia and their length, and defects in cilia‐dependent sonic hedgehog signalling. In addition to its similarity with the septin ring of yeast cells, the localization of ciliary septins is reminiscent with that of SEPT4/12 at the annulus of the sperm tail (Fig 1B; Ihara et al, 2005; Kissel et al, 2005; Steels et al, 2007; Caudron & Barral, 2009).
How is the ciliary membrane insulated from the plasma membrane? FRAP assays of ciliary membrane proteins showed that although the proteins diffuse freely within the ciliary compartment, they do not display fluorescence recovery when the entire ciliary pool is bleached (Hu et al, 2010). Thus, their exchange with the rest of the plasma membrane is restricted at the base of the cilium. By contrast, non‐membrane proteins exchange rapidly between the cilium and the cell. Remarkably, disruption of the septin ring at the base of the cilium by RNAi markedly increases the diffusional mobility of the ciliary membrane proteins between the cilium and the remainder of the plasma membrane (Hu et al, 2010). These data indicate that the septin ring at the base of cilia might mediate the formation of a lateral diffusion barrier that insulates the inner leaflet of the ciliary membrane from the plasma membrane. Notably, proteins mutated in nephronophthisis and Meckel syndrome localize to the base of cilia in a similar way to septins, where they link the axoneme to the ciliary membrane and might also have a barrier function (Williams et al, 2011). Furthermore, lipids are more condensed at the base of the cilium than in the apical part or in the surrounding plasma membrane (Vieira et al, 2006). Thus, accumulation of specific lipids and other proteins are likely to function together with septins in barrier formation.
Are the septin‐dependent diffusion barriers impermeable, or do they only slow down the kinetics of molecule exchange between compartments? For the diffusion barriers in yeast, the latter is probably closer to reality (Valdez‐Taubas & Pelham, 2003; Luedeke et al, 2005). If septin filament assembly is actually required for barrier formation in cilia as in yeast, the orientation and/or dynamics of these filaments are likely to determine the tightness of the barrier. How can the ciliary diffusion barrier be selective to allow some membrane proteins to enter whereas others are excluded? If the diffusion barrier allows some 'leaky' diffusion, this might promote proteins that are able to transiently interact with septins (or septin‐associated molecules) to enter the cilium. This process might also be aided by the IFT machinery. By contrast, if septins form a tight barrier, import of membrane proteins would depend solely on vesicle delivery (Fig 2A). Some proteins containing a PDZ‐binding motif—such as podocalyxin—might also be retained outside the cilium through interactions with an apical protein network composed of NHEFR, ERM proteins and actin (Francis et al, 2011). Thus, keeping some proteins in and excluding others from the cilium might in some cases be two distinct processes. Collectively, these data indicate that a lateral diffusion barrier formed by a scaffold of proteins (including septins) and possibly highly ordered lipids, controls the movement of membrane‐bound material in and out of cilia. How the barrier works in terms of establishment, plasticity and selectivity remains to be determined.
Is septin function in ciliogenesis restricted to the formation of a diffusion barrier? The reduced number of cilia in SEPT2‐depleted cells might be due to the dissolution of the cilia in the absence of a barrier, although this phenotype might also reflect the additional roles of septins during early ciliogenesis. Septins might direct the delivery and anchorage of vesicles to the basal body and/or inhibit their docking to the plasma membrane, as in neuronal synapses (Yang et al, 2010). It is unknown how vesicles initially reach the basal body and how subsequent vesicles are tethered to and fused with the ciliary membrane. SEPT2, which has a role in the transport of Golgi vesicles to the apical surface of epithelial cells (Spiliotis et al, 2008), might be involved in this process. Importantly, mammalian septins interact with and regulate the exocyst complex by directing it to the correct location and by regulating membrane fusion (Estey et al, 2010; Amin et al, 2008; Beites et al, 1999, 2005). Furthermore, the exocyst pathway contributes to the function of the PCP pathway during ciliogenesis, as the PCP protein Dishevelled mediates recruitment of Sec8‐positive vesicles to the basal body (Park et al, 2008). These observations are particularly suggestive, because it was shown that SEPT2/7 depletion phenocopies the knockdown effect of the PCP component Fritz during Xenopus gastrulation and ciliogenesis (Kim et al, 2010). Remarkably, Fritz interacts with septin and Fritz controls the proper localization of septins during ciliogenesis. Thus, in addition to forming a diffusion barrier, septins might function in vesicle transport and the formation of the ciliary membrane, together with the exocyst and the PCP pathway (Fig 2A).
Septins are also good candidates to organize spatially the regulation of the BBSome, a protein complex linked to the Bardet–Biedl syndrome, which functions in the sorting and docking of vesicles to the base of the cilium, together with Rab8, Rab11 and Rabin8 (Knodler et al, 2010; Nachury et al, 2007). Localization of the BBSome to the membrane depends on BBS3, also known as the Arf GTPase Arl6 (Jin et al, 2010), which localizes to the base of the cilium in a ring‐like array similar to septins (Wiens et al, 2010). Since mutations in Fritz are associated with BBS (Kim et al, 2010), it is tempting to speculate that a molecular pathway links PCP, septins and the BBSome in the regulation of ciliogenesis and ciliary transport.
Finally, septins might contribute to the regulation of microtubule function during ciliogenesis. First, septins localize partly to the ciliary shaft (Hu et al, 2010; Kim et al, 2010), where they might regulate microtubule dynamics and vesicle transport. A recent study showed that, during epithelial polarization, septin scaffolds guide the growth and direction of microtubules by suppressing their disassembly (Bowen et al, 2011). Previous studies have also established that septins regulate microtubule stability through association with MAP4, microtubule acetylation and binding to polyglutamated microtubules (Fig 3A; Kremer et al, 2005; Nagata et al, 2003; Spiliotis et al, 2005, 2008; Spiliotis, 2010; Surka et al, 2002). Most intriguingly, however, the unique localization of septins to the base of the cilium makes them prime candidates for membrane attachment of the transition fibres. This possibility is attractive because budding yeast septins also contribute to the capture of astral microtubules to the plasma membrane (Kusch et al, 2002), and thereby to the proper localization of the centrosome and basal‐body‐equivalent to the bud neck (Figs 1A,2A). This interaction is mediated by MAP Kar9, which is at least functionally related to metazoan adenomatous polyposis coli (APC). Remarkably, deletion of APC in the renal epithelia of mice results in polycystic kidneys, a common consequence of cilia dysfunction (Qian et al, 2005). It will be interesting to test whether septins control microtubule organization in cilia.
Septins in the central nervous system
Another prime example in which a septin ring might function in cell compartmentalization comes from neurons. Many septins are abundantly expressed in the CNS where they display cell‐type‐specific expression patterns (Tada et al, 2007; Buser et al, 2009) and are associated with diverse neuropathological conditions (Table 1). Many septins localize in ring‐like assemblies at the base of dendritic spines and to dendritic branch points of hippocampal neurons. Knockdown of SEPT7 or SEPT11 reduces dendritic branching and spine density, whereas SEPT7 overexpression has the opposite effect (Cho et al, 2011; Li et al, 2009; Tada et al, 2007; Xie et al, 2007). Dendritic spines are small protrusions on dendrites that function in processing and storing information. Although thousands of spines reside on the same dendrite, each of them functions independently from the others, indicating that each spine is functionally insulated. This insulation occurs partly at the spine neck, which restricts exchange of molecules between the spine head and the dendrite (Ashby et al, 2006; Bloodgood & Sabatini, 2005). Analogously to cilia, septins localize to the base of spines (Figs 1B,2B). However, whether septins affect the diffusion dynamics of membrane proteins in and out of spines is unknown. Individualization of spines contributes to memory formation and thereby septin defects might have an impact on this process. SEPT7 expression increases during formation of spatial memory in mice, which supports this idea (Engmann et al, 2011). Together, these data indicate an evolutionarily conserved function of the septin ring in individualizing subcellular structures.
As in the cilium and the yeast bud neck, the function of septins in the dendrites is probably not restricted to barrier formation, but might extend to the modulation of actin and microtubule organization. For example, the septin interaction partner myosin NM2 is required for proper morphogenesis of the spine neck and head (Ryu et al, 2006; Joo et al, 2007). Microtubules are also found in some spines (Dent et al, 2011). These events might be orchestrated by septins (Fig 2B). Similarly, interactions between septins, actomyosin and microtubules might underlie the role of septins in dendritic branching and neuronal migration (Shinoda et al, 2010).
Septins control several essential functions of neuronal cells in vitro, septin knockout mice show relatively mild phenotypes in CNS function. SEPT4 knockout mice have reduced dopaminergic transmission at the synapses of the striatonigral pathway and increased aggregation of α‐synuclein, which are phenotypes associated with Parkinson disease (Ihara et al, 2007). Knockout of SEPT6, SEPT5 or SEPT3 alone or of SEPT5 and SEPT3 together does not lead to any gross abnormalities in CNS morphology in mice (Fujishima et al, 2007; Ono et al, 2005; Peng et al, 2002; Tsang et al, 2008). However, SEPT5 knockout mice behave abnormally (Suzuki et al, 2009). Together, these data indicate that the various septins have partly redundant roles in the CNS.
Septins and cell migration in cancer invasion
The septin ring paradigm might not always be well‐suited to explain the reported functions of septins. Changes in the expression levels of septins have been found repeatedly in different types of cancer (reviewed in Connolly et al, 2011b; Peterson & Petty, 2010). There are many ways by which septins could contribute to tumorigenesis, ranging from their role in cell cycle progression (Spiliotis et al, 2005; Estey et al, 2010; Peterson & Petty, 2010), to the DNA damage response (Kremer et al, 2007) and being MLL fusion partners in leukaemia (Connolly et al, 2011b). Recently, considerable progress has been made in understanding the function of septins during cell motility and invasion—processes underlying cancer metastasis (Gonzalez et al, 2007; Shankar et al, 2010). Indeed, changes in septin expression alter single and collective modes of cell migration (Connolly et al, 2011a; Kim et al, 2010; Shankar et al, 2010; Tooley et al, 2009).
Orchestrated cellular movement depends on actin‐polymerization‐driven or bleb‐expansion‐driven protrusions at the front of the cell, followed by contractility‐driven retraction of its rear. The requirements for adhesion, contraction and protrusion vary largely, depending on the mode of migration (Lämmermann & Sixt, 2009). T cells, which migrate in an amoeboid‐like manner, express multiple septins—SEPT2/4/6/7/8/9/11—which form a 'corset' around the rear of these cells. Importantly, this rear, commonly known as the 'uropod', has a different molecular identity to the front of the cell. This asymmetry is partly driven by the enrichment of PI(4,5)P2, and PI(4,5)P2‐binding proteins at the rear (Lokuta et al, 2007), which might enhance plasma‐membrane–actin linkage and prevent unwanted protrusions. It is possible that the septin corset promotes this asymmetry by restricting lipid diffusion between the front and rear of the cell.
Interestingly, the polymerization of septin complexes into filaments and sheets is enhanced on the surface of lipid monolayers that contain PI(4,5)P2 (Bertin et al, 2010), and septins are also regulated by PI(4,5)P2 in vivo. Septins and PI(4,5)P2 localize together at the yeast bud neck (Garrenton et al, 2010) and the furrow of dividing mammalian cells (Field et al, 2005), and experimental conversion of PI(4,5)P2 into PI(3,4,5)P3 causes disassembly of the septin ring in yeast (Bertin et al, 2010; Rodriguez‐Escudero et al, 2005). These data indicate that PI(4,5)P2 might have a major role in recruiting and orchestrating the assembly of septin complexes and higher‐order assemblies in cells, but how this occurs is not yet known.
Remarkably, knockdown of the core structural unit of the T‐cell corset, SEPT7, impairs cell migration but enhances cell invasion through narrow spaces. Additionally, it induces plasma membrane blebbing, a phenotype also seen after SEPT7 depletion during Xenopus gastrulation (Kim et al, 2010). Blebbing represents a protease‐independent mode of 'amoeboid‐type' cell motility that is used by leukocytes, invasive cancer cells and during developmental cell migration (Lämmermann & Sixt, 2009). The septin corset, which provides rigidity to the plasma membrane, might help cells to maintain direction during migration by preventing protrusions at the uropod. Consequently, loss of the septin corset might change the migratory behaviour of the cell by promoting blebbing, making the cell more elastic, and thus explaining why septin loss enhances the ability of cells to squeeze through narrow holes (Tooley et al, 2009). In favour of this model, SEPT2/11‐depleted HeLa cells display reduced cortical elasticity as measured by AFM (Mostowy et al, 2011). This phenotype is mimicked by disruption of actin filaments, suggesting that submembranous septin assemblies impose similar rigidity to the plasma membrane as does the actin cytoskeleton. Furthermore, septins localize to submembranous actin filaments, and FRAP studies have shown that septin turnover is decreased after stabilization of actin filaments (Hagiwara et al, 2011). Thus, septins might function in membrane–actin linkage and/or promote plasma membrane rigidity by themselves. In either case, subtle disturbances in septin expression might predispose cells to blebbing and promote invasive behaviour of cancer cells.
In addition to maintaining plasma membrane rigidity, septins might contribute to the actomyosin contractility of motile cells. The abnormally long tail of septin‐depleted migrating T cells could reflect this. Septins associate with the actin cytoskeleton both in yeast and mammals (Norden et al, 2004; Surka et al, 2002). In mammals, they associate with contractile actomyosin structures in non‐muscle cells, both at the cleavage furrow and in stress fibres (Fig 3B; Joo et al, 2007; Kinoshita et al, 2002; Kremer et al, 2007; Mostowy et al, 2009; Surka et al, 2002) and also localize to focal adhesions where stress fibres are assembled (Bowen et al, 2011). The association with actin occurs indirectly, through binding to anillin and/or NM2 (Joo et al, 2007; Kinoshita et al, 2002). Anillin recruits septins to the actomyosin ring during cell division, but resides in the nucleus during interphase (Oegema et al, 2000). Therefore, during cell motility, septins probably associate with actomyosin by binding to NM2 (Joo et al, 2007). Although the function of septin–actomyosin interactions is incompletely understood, septins seem to act as a regulatory platform on contractile structures by recruiting myosin regulatory molecules such as ROCK and CRIK, to promote MLC phosphorylation and thereby contractility (Fig 3B; Joo et al, 2007). Notably, in yeast, septins also contribute to the recruitment of formins (Pruyne et al, 2004), although it is not clear how or whether this is also the case in metazoans. Finally, some septins—such as SEPT10/11—seem to be highly expressed in muscle tissue (http://biogps.gnf.org/). Thus, septins might have a more general role in actomyosin contractility than appreciated. All together, while the roles of septins in controlling cell motility are only starting to emerge, they are likely to involve the conserved functions in forming plasma‐membrane‐apposed barriers and scaffolds, and regulation of actomyosin contractility. Future studies will have to determine whether these functions are coupled to each other, and whether changes in septin expression indeed promote metastasis.
An army of septins fighting infectious pathogens
Microorganisms hijack host‐cell machineries for different aspects of their life cycle. Septins have a general role in phagocytic processes, which can either act as an entry mechanism for microorganisms to promote infection, or as a host‐cell defence mechanism leading to the elimination of the microbe. Phagocytosis is initiated when a 'professional' phagocyte—for example, a macrophage—encounters a microorganism. This leads to the sequential accumulation of phosphoinositide lipids, reorganization of submembranous actin and bending of the plasma membrane to form a cup‐like protrusion around the microorganism. The phagocytic cup eventually seals and internalizes the target particle. The pathogen is then either degraded or escapes into the cytosol (Flannagan et al, 2009). Many septins (including SEPT2/6/10/11) are highly expressed in expert phagocytic cells, and SEPT2/11 transiently localize to Fcgγ‐receptor (FcgγR)‐dependent phagosomes of different cell types (Huang et al, 2008). The appearance of septins is concomitant with PI(4,5)P2 and F‐actin accumulation at these sites, although septin inhibition reduces phagocytosis without any obvious effects on the actin cytoskeleton (Huang et al, 2008). Interestingly, SEPT2/9/11, also in 'non‐professional' cells, concentrate beneath the attachment site of Listeria monocytogenes and Shigella flexneri bacteria, where they appear to form a ring‐shaped collar and are important for bacterial entry (Mostowy et al, 2009). Despite the importance of septins for FcgγR‐dependent phagocytosis and bacterial intake, their exact role remains unclear. A recent study in yeast showed that the septin ring assembled at the bud site maintains cell polarity by preventing Cdc42 diffusion from this site (Orlando et al, 2011). In a similar manner, during phagocytosis, septins might act to maintain local plasma membrane identity, possibly increasing membrane–cytoskeleton linkage and/or slowing down the dispersion of activated receptors and their targets to boost signalling and uptake.
Septins are also involved in later stages of Shigella and Listeria infection. Once internalized, Shigella and Listeria recruit the host‐cell actin polymerization machinery to drive their intracellular and intercellular motility (Gouin et al, 2005). Surprisingly, intracellular bacteria with F‐actin around them often display stable perpendicular filamentous rings, or 'cages', containing SEPT2/6/9/11 (Mostowy et al, 2010). These cages are not present around Shigella cells that lack actin staining, indicating that actin recruitment is a prerequisite for septin cage assembly. Surprisingly, NM2 and phosphorylated MLC also localize around the internalized bacteria and are required for septin cage formation (Mostowy et al, 2010). Importantly, septin cages suppress actin tail formation and the intercellular spread of bacteria (Mostowy et al, 2010). Moreover, they seem to represent an intermediate stage toward uptake and degradation of the bacterium by autophagy (Mostowy et al, 2010). Thus, septins function in determining the fate of internalized bacteria and as such are part of the host immune response. It is interesting to note that, by promoting autophagy, septins link cellular objects—such as actomyosin‐surrounded bacteria—to membrane organization—such as formation of the phagophore—and compartmentalization of cellular space.
Conclusions and future perspectives
The recently identified roles for septins in higher eukaryotes have placed septin assemblies in structurally and functionally diverse subcellular structures; however, an increasing body of evidence suggests that the underlying molecular functions of septin assemblies are conserved across these processes from yeast to mammals. The assemblies act to spatially specify, recognize and individualize subcellular membranes and the structures associated with them. Furthermore, they form platforms that link membranes to actomyosin contractility and microtubule dynamics. The evolution to multicellularity seems to correlate with a more complex landscape of septins, septin complexes and the higher‐order structures that they form. This plasticity has allowed septins to promote the formation and maintenance of a much wider panel of cellular appendages and ultrastructures, each with different dynamics. How septin function is modulated and adopted to the controlled formation of such a variety of structures, and how septins contribute to the function of these appendages, are important areas for future research (Sidebar A).
Sidebar A | In need of answers
What are the factors that dictate when and where septin assemblies are generated? Do different septin complexes differ in function and if so, how?
Do certain lipids and/or membrane curvature prime septin filament assembly and can septin assemblies generate and/or stabilize membrane curvature in cells?
What roles do the ring‐like septin assemblies have in cells and how are septins assembled in these rings (Fig 1C)? How exactly do septin‐dependent diffusion barriers function?
What interfaces are used for septin–myosin and septin–tubulin interactions? Can septins crosslink the actin and/or microtubule cytoskeletons to membranes or are these interactions mutually exclusive?
Conflict of Interest
The authors declare that they have no conflict of interest.
This work was supported by a Federation of European Biochemical Societies (FEBS) Long Term Fellowship to J.S., and an advanced European Research Council (ERC) grant to Y.B. We thank Fabrice Caudron, Annina Denoth, Manuel Hotz and Alexander Rauch for comments on the manuscript and apologize to authors whose work we could not cite due to space limitations.
- Glossary
- atomic force microscopy
- BBSome
- Bardet‐Biedel syndrome proteins
- central nervous system
- citron kinase
- ezrin‐radixin‐moesin domain
- FcγR
- Fc gamma receptor
- fluorescence recovery after photobleaching
- intraflagellar transport
- Kar9
- karyogamy protein 9
- microtubule‐associated protein
- myosin light chain kinase
- mixed lineage leukaemia
- type II non‐muscle myosin
- Na+/H+ exchanger 3 regulatory factor
- planar cell polarity
- PSD95‐DlgA‐ZO1 domain
- RNAi
- RNA interference
- Rho kinase
- septin
- Copyright © 2011 European Molecular Biology Organization


text:
Visit The Dirt Forum for More Information
Topic: tire heat
Dirt Roller
Total posts: 21
posted September 19, 2005 11:49 AM
This passed saturday the car handled great at the beginning of the feature race but about halfway into the race the car started to tighten up and push a liitle to the wall coming out of the turns. I think the tires are heating up and the air pressures are rising. My current pressures are lf 15,rf 23,lr 18,rr18. I'm also running 3" front stagger, and 1.5" rear stagger. Any advise on air pressure to keep the car slightly loose greatly appreciated.Thanks.
Dirt Roller
Total posts: 21
posted September 19, 2005 03:00 PM
One thing I forgot to mention, I'm running 3" offsets all the way around the car. I have a couple of 2" off wheels, so were should I put them to loosen the car up a bit, or should I just adjust air the pressure.
Dirt Maniac
Total posts: 161
posted September 19, 2005 04:02 PM
Increase the rear stagger to 21/2" reset the wheel weights back to original & try
that. The stagger will help keep the car turning on exit.
Dirt Newbie
Total posts: 4
posted September 22, 2005 12:00 PM
in practise run so hot laps and see how your tires grow and then just try to get them to grow as evenly as you can .
Back to the Archives


text:
SALVES and CREAMS
All our salves and creams are made in small batches using traditional Native
American formulas. The salve base is olive oil and beeswax. We use no petroleum
products or perfumes. We use no animal testing.
All our creams and salves are available in three sizes:
1/4 oz trial size $9 one ounce $36
4 ounces $109
NATURAL SKIN CREAM, lavender
NATURAL SKIN CREAM, mint
This traditional Native American formula is used to help soothe and heal all skin conditions. Moisturizes skin and helps
heal itching, redness, and inflammation. It is all natural, petroleum free, fragrance free, dye free and contains no
artificial preservatives. The lavender cream contains lavender oil and helps heal burns and lessen scar tissue.
Ingredients: Olive oil, beeswax,
Urtica dioica, Aloe vera
Mentha spicata
Vitamin C as a preservative.
This traditional Native American formula is used to relieve pain, inflammation, and help heal joints, tendons and
muscles. It is useful for arthritis, to relieve aches, and help heal strained joints and muscles caused by injury or
overwork. Also helps with neuropathy, neuralgia, carpal tunnel, plantar fasciitis and other painful conditions.
Ingredients: Olive oil, beeswax,
Hypericum perforatum, Symphytum officinale, Mentha spicata
, alcohol, Vitamin C as a
Checks or money orders may be made payable to:
450 Davidson Chapel Lane
Bloomington Springs, Tennessee 38545-7075
To pay by credit card, you may use paypal to
pay Lisa Bedner at email@example.com
All prices include tax and shipping unless otherwise noted.
REQUIRED FDA WARNING: All the products and statements about the products on
this website have not been evaluated by the FDA. These products are not intended to
treat, cure, or prevent any disease or illness.
All our lotion are made and in small batches. They are aged at least one year before
being offered for sale. The base is witch hazel. We use no petroleum products or
Lotions are available in one size only: 6 ounce applicator bottle. $18.00 includes shipping.
This traditional Native American formula is used to heal, dry, and soothe painful and inflamed skin. Works well to dry
and heal wet rashes, inflamed skin, and blisters. Also soothes itchy insect bites.
Ingredients: Witchhazel U.S.P.,
Urtica dioica
, and alcohol.
This traditional Native American formula is used to soothe and help heal itching, redness, pain and and
inflammation of rashes caused by irritating plants: Poison Ivy, Poison Oak, Poison Sumac, and Stinging Nettle.
Helps heal and dry the rashes and blisters caused by these plants.
Ingredients: Witchhazel U.S.P.,
Impatiens capensis
, and alcohol.
All of our tinctures are made in small batches. Tinctures
are all made from organically grown fresh herbs,
processed within hours of harvest. They are aged 6
months to one year before being offered for sale. We sell
most of our tinctures by request of either client or
practitioner. Below is a partial listing of our most popular
tinctures. Please email or call if you need a single herb or
combination tincture that you don't see listed.
All tinctures are sold in one ounce glass dropper bottles. Price is $22.00
including shipping. Three or more for $20 each.
BLUE VERVAIN Verbene hostata
BUGLEWEED Lycopus virginicus
COLTSFOOT Tussilago farfara
DANDYLION LEAVES Taraxicum officinale
FEVERFEW Tanacetum parthenium
LOBELIA Lobelia inflata
MOTHERWORT Leonurus cardiaca
MULLEIN Verbascum thapsus
PASSIFLORA Passiflora incarnata
SCULLCAP Scutellaria laterifolia
ST. JOHNSWORT Hypericum perforatum
YARROW Achillea millefolium
For many years I have dealt with neuropathy and neither
over the counter or prescription medications have
provided any relief from nerve pain or discomfort. That is,
until I started applying Lisa Bedner's Herbal Salve for
Joints, Whenever I am asked for a recommendation for
the best topical salve for neuropathy, without hesitation, I
tell those asking to find Lisa Bedner and get her Herbal
Salve for Joints."
S. Gilbert, Gainesboro, TN
WE GROW ALL OUR HERBS ORGANICALLY, harvest
them by hand, and prepare them fresh, honoring the
Earth Mother in the traditional Native American way.
Use this traditional Native American inhalation formula to relieve congestion and help ease breathing. It is useful
for treating sinus congestion, inflammation, and headaches due to colds, flu, allergies, and other sinus irritations.
Ingredients: Pycanthemum incanum and Eucalyptus globulus
Price: 20 treatments per 1 oz. weight Jar, including postage...$20
This is our newest product. People have asked for
a version of the old "Vicks Vap-o-rub" without the
petroleum and turpentine.
Ingedients: : Olive oil, Beeswax, Camphor (from
Rosemary leaves), Eucalyptus, Menthol
(Pycanthemum mints), Thyme
This product is only available in limited quantity until
Fall 2015
We sell a variety of Parasite Cleanses, depending on the age, allergies, medical history and digestive system of the
individual. Please contact us via email email@example.com so we can determine which cleanse is best for you.
In traditional Native American Medicine, a parasite cleanse begins any treatment for serious or chronic illness. Parasites
are not always visible in bowel movements. Anyone who eats meat or dairy products, drinks city or well water, or is
exposed to any other toxins in the environment is at risk for parasites. Travel to foreign countries also increases risk. A
parasite cleanse process is simple, painless, and usually has little or no side effects. A parasite cleanse also prepares
the bowel and makes it more receptive to absorbing other herbs.
One of our Parasite Cleanse packs contains the full dosage for one treatment for an adult . Doage is determined by age
and weight. We also include instructions for before, during, and after the cleanse. Parasite Cleanse instructions and
dosages are for adults. Please consult your health care practitioner for pediatric usage.
Ingredients: (may include all or some of these herbs) Artemesia absynthium, Artemesia annua, Chenopodium
ambrosoides, Juglans nigra, and Syzygium aromaticum.
Artemesia's and Chenopodium work on acitive parasites, Juglans nigra works on dormant parasites, and Syzygium
aromaticum work on parasite eggs and egg casings. It is important to take these herbs in a combination of particular
proportons. It is also important to do no more than one cleanse per month, and 3 cleanses per year.
Price: One treatment per Pack plus instructions, including postage...$18.00 each;
Two or more Packs per order.....$15.00 each


text:
1999, 2 x 45', ORF/Cinevision
The fear of the end of the world is ancient. Most likely the sight of a raging thunder storm caused early men to think the world was coming to an end. Every epidemic or catastrophe of nature was considered to be a punishment of the gods. As a sign for the nearing end. And every time the end didn't come about , the date for the end was postponed. This persistent belief of the end of the world seems inexplicable. In every epoch, the human race believed their time was up. In the last two thousand years, there is a prophecy for the end of the world for almost every single year. But, what do all these prophecies have in common? They were all wrong.
Today, we know that every 25 to 30 million years, something happened that almost caused the end of the world. The distinction of the dinosaurs was not the only case: there have been lots of mass deaths. For example, 230 million years ago, 96% of all the living creatures in the oceans and on land died. Our species has been on the earth for only one hundred million years - a very short time, when you consider our planet's age: 15 billion years old. And yet we have had an enormous influence on our earth. As we know, not always to the best.


text:
2019 Chevrolet Silverado 1500: Spoilt For Choice
After all that teasing, we finally got to see what the 2019 Chevrolet Silverado 1500 is all about and fans will be happy to know what Chevrolet will be giving them a few engine options this time including the highly requested diesel engine.
According to Chevrolet, the vehicle will be coming with three engine options. Gasoline option will include the 5.3 liter V8 and the 6.2-liter V8 engine. Those looking to get the diesel option will be offered the 3.0 liter Duramax turbodiesel inline six engine.
GM did not reveal any new detail about the power, fuel economy and towing capability but they did reveal that the engine will be fitted with the new 10-speed auto transmission. Customers will also get to choose from eight trim level divided into High Value, Work Truck, and High Value.
No word on when the truck will be arriving and we will still have to wait for GM to reveal the price list for the 2019 Chevrolet Silverado 1500


text:
Placenta encapsulation, tinctures, essence and homeopathic remedies - all made from your body's own gift of hormones packed into a placenta after birth! Call us for more information regarding ourrange of services that include pregnancy yoga, baby massage, antenatal courses and birth doula support.
Show businesses near Henley in Arden


text:
After This Dog Woke Up From Scary Surgery, Then Vet Does Something That Shocks Everyone
Man Rescues A Homeless Retriever Affected By Flood. What He Finds In His Fur Will Terribly Shock You
Little Cara Discovers Something Really Ghastly Under A Woodpile. Guess What That Is?
You Wouldn't Believe What These Dogs Did To Bid The Baby Girl Goodbye
Not everyone is fortunate enough to have grown up with a pet but those who have lived with one, know the true worth of spending time with animals. PIT BULLS BIBLE shares a truly heart-warming incident where a kid as young as four years runs to his mom with an amazing idea after getting to know that he couldn't adopt a dog.
When Elyse Betschart took her son Jaxton to Charleston Animal Society in South Carolina to be able to study and know about a pit bull amend Penelope, he fell in love with another pit bull, Tank. He went so obsessed with Tank that he wanted to take it home immediately.
He went to Tank's cage and said, "Mommy! He's big and chunky just like me!" But since they belonged to a military family, they couldn't adopt a dog. Any kid of Jaxton's age would have gone home crying or sit disheartened but this kid was special. He wanted to give Penelope and Tank new and loving homes so he decided to sponsor them with his allowances.
He gave up all the money that he saved for the adoption fee as sponsorship for the 2 dogs. Elyse says, "A lot of people don't realized that sponsorship is an option, that you can actually tie that money to a face,"
If Jaxton's generosity touched your heart, SHARE his story with all your friends.


text:
|Munib Nawaz
|Ammar Belal
|Umar Sayeed
|Umar Sayeed Bridal Collection
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Good Luck and well done.
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This comment has been removed by the author.ReplyDelete
This comment has been removed by the author.ReplyDelete
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kisi ko sirf Ezzat milti hai.
buht kam log hain jinhe ye tamam cheezain milti hain
ap un khushnasibon main se hain jinhe ye sab kuch ALLAH pak ne ata farmaya hai
ALLAH pak se dua hai k ALLAH pak apko isi tarah kamyaab O kamrani Ta farmaye AMMEN
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I luv you FawadReplyDelete
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And I am pretty sure he won't appreciate these kinda comments.
Yes.... "FAWADSBIGGESTFAN"is right :) !!Delete
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really is so nice actorReplyDelete
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yr fawad ke shadi hoi we hai ab kya faida love krne kaDelete
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I've been following the serial ZINDAGI GULZAR HAI in Zindagi channel, in India. For a change, a different concept, easy flow of drama etc. Feeling sad, it would end this Saturday.ReplyDelete
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Fawad I am your fan from Lucknow, India and I admire you a lot...
Allah aapko sehat aur kaamyabi de...
Lots of wishes
What is your height?ReplyDelete


text:
Bangkok Visitors Guide
About Bangkok
Bangkok was founded in 1782 and is the capital city of Thailand. It is known as "Krungthep" to the locals which means the "City of Angels". Bangkok has developed rapidly over the years and is now a popular travel destination in Asia. The city is always bustling with a variety of activities, from exotic temples, to modern shopping malls, to floating markets, to street markets, including of course, Chatuchak Weekend Market, one of the world's largest markets. Be prepared to be won over by Bangkok's versatility and multiple points of interests during your visit.


text:
Sheep Racer
Help the sheep to get to the finish line. Use the mouse to drive, speed up or slow down. Left click to jump over the empty spaces and try to collect as much flags as you can.
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text: CCSHCN clinics provide a family centered multidisciplinary approach to care. During each visit, children and families have access to nutritional services, social services, care coordination through a registered nurse, and specialty physicians. Physical and occupational therapies are included for clinics serving children with orthopedic conditions and cerebral palsy. Speech therapy is available for children with hearing loss or other conditions that affect speech and language development. Clinics that treat complex conditions offer the services of multiple physicians who provide a team approach to the management of these complex conditions.


text:
|Number of Pax
|10 Pax
|15 Pax
|20 Pax
|25 Pax
|Twin Sharing
|SGL Supplement
|Number of Pax
|10 Pax
|15 Pax
|20 Pax
|25 Pax
|Twin Sharing
|SGL Supplement
Package Excludes:
New Year Holidays: 27th Dec 2019-3rd Jan 2020
On arrival at Dubai Airport, meet & assistance by German Speaking Guide. Transfer to Hotel in Dubai. Overnight at the Hotel.
Dubai is one of the few cities in the world that has undergone such a rapid transformation - from a humble beginning as a pearl-diving center - to one of the fastest growing cities on earth. Dubai today is a tourism, trade and logistics hub and has earned itself the reputation of being the 'gateway between the east and the west.
Dubai enjoys an arid subtropical climate, with blue skies and sunshine all year round. Temperatures range from lows of 10°C to extreme summer highs of 48°C. The average maximum daily temperature in January is 24°C and the average maximum daily temperature in July is 41°C when humidity is very high. The temperature in November will vary from an average of 20°C to 30 °C.
The official language of the UAE is Arabic, but English is widely spoken and understood in business and commerce. Although Dubai has a liberal attitude, it is always wise to respect the religion and culture of the city by wearing appropriate, more modest clothing in public places. The electricity supply in Dubai is 220/240 volts at 50 cycles. Plug points are the same as in the UK.
The water in Dubai is desalinated and very safe to drink. Officially, the metric system is followed. The flora of Dubai is filled with indigenous date palms. Towards the east, flat-topped acacia trees and wild grass is found scattered in the mountains. Desert oases are also found in areas where the land is uniquely green. Dubai has a diverse and multi-cultural society. However, Dubai's culture is shaped by the Islamic traditions of Arabia, with religion touching all aspects of everyday life in the country.
DUBAI MUSEUM: The eighteenth-century Al Fahidi Fort, which now houses The Dubai Museum, includes local antiquities as well as artifacts from African and Asian countries that traded with Dubai. A visit to Dubai Museum "Al Fahidi Fort" offers an opportunity to get acquainted with the history of Dubai, which gives an impression that Dubai's current development, modernism, and distinction are only a continuation of a journey of a unique and distinguished civilization that was subjected to different cultures and people, as well as an example of the strong bond with Arabism and Islam.
ABRA RIDE: Without the creek and abra, Dubai would not exist. Dubai's abra has been transporting people across the creek for as long as anyone can remember. Once powered by oars, tiny engines now push the 20-person; It takes only ten minutes to cross between Deira and Bur Dubai in an abra. Notably, abras are used by 15 to 20 million passengers annually, and they are growing in popularity. There is a genuine feeling of history as you step on board.
BASTAKIYA: The tiny Bastakiya quarter is Dubai's most engaging neighborhood. Established at the end of the 19th century by well-to-do textile and pearl traders from Bastak, Iran, its labyrinthine lanes are lined with restored merchant's houses, art galleries, cafés, and boutique hotels. "The Bastakiya is a picturesque step into Dubai's past.
CULTURAL TOUR: Enjoy a traditional Emirati lunch at the Sheikh Mohammed Centre for Cultural Understanding in the ambiance of a wind tower house. Al Fahidi neighborhood, are an excellent opportunity to learn within an informal Environment. The topics of discussion are generated by questions from the guests and lead by one of our cultural presenters. The programme is designed to be entertaining, educational and informative. Topics include Arabic culture, Islam and its impact on local culture, cultural values and sensitivities, important Arabic greetings and expressions as well as insightful anecdotes.
|Rate Slab
|Rate(Per person)
|6-11 pax (price per person)
|Includes an architect guide and a car or minivan with driver. Monorail ticket, Lunch at a restaurant in Atlantis the Palm and Entrance ticket for AT THE TOP in Burj Khalifa
|12-25 pax (price per person)
|Includes an architect guide and all transfers Monorail ticket, Lunch at a restaurant in Atlantis the Palm and Entrance ticket for AT THE TOP in Burj Khalifa
Breakfast at the hotel. By morning, proceed for a Full Day Dubai Architectural Tour, starts at 09:30 from the hotel.
Visit the presentation-center of the government owned development company Nakheel. With a total investment of more than 30 bn. US$, Nakheel is one of the largest developers worldwide. Nakheel is responsible for the spectacular off-shore projects as the Palm Islands and The World. Projects will be presented and discussed with the aid of models and satellite plans. Trip onto the Palm Jumeirah via Monorail. Last stop is at the Aquaventure Waterpark, followed by a short tour and explanation of the Atlantis Hotel.12:30-13:30 Lunch break at Atlantis the Palm with soft drinks and water.
With more than 200 high-rise buildings completed in the last 5 years, Dubai Marina has become a city within a city, surrounding a 3,3 km long artificial yacht harbor. Stops at Marina Walk or Jumeirah Beach Residence with explanations
Opened in 2004, the Souk Madinat Jumeirah forms the center piece of this Hotel, Shopping and Events complex.
Flanked by the 5-star luxury resorts Mina A'Salam und Al Qasr, it successfully mimics the style of the traditional Arabian markets. A comprehensive tour through the compound with its canals and palaces.
The Business Bay development of Dubai Properties stretches along the 11km Dubai Creek extension and covers an area of 47 million square feet. More than 230 towers are planned of which 60 to 70 are under construction. Visit of the presentation center and tour with stops through this vast construction site. Since opening in September 2004, Dubai International Financial Centre (DIFC) has attracted high-profile companies from all over the world. The rational architecture of the American-English office Gensler gives the DIFC an appearance of the highest international standards.
Designed by Skidmore, Owings, and Merrill, the Burj Khalifa is the tallest structure in the world. Since its completion in January 2010 the 828m high tower features also the highest occupied floor, and for the first time unifies all world records for tall buildings since the construction of the Empire State Building in New York in 1931. Visit the observation deck «At The Top» at level 124.
Surrounding Burj Khalifa, master developer Emaar has created Dubai's new downtown ensemble, complete with the world's largest shopping mall and a 'new old town'quarter. Walk around the central lake with Dubai Fountain show
The Sheikh Zayed Grand Mosque, an architectural work of art is one the world's largest mosques, which features 82 domes, over a 1,000 columns, 24-carat gold gilded chandeliers, and the world's largest hand-knotted carpet. The prayer hall is dominated by one of the world's largest chandeliers –10 meters in diameter, 15 meters in height.
Emirates Palace, a real iconic Abu Dhabi landmark, a luxurious hotel blends Arabian splendor with the latest technology to create a magical and memorable experience. During daytime, the hotel's golden-sandy color contrasts with its fresh green gardens, silvery water fountains and the blue sky.
Heritage Village, a traditional oasis village provides an interesting glimpse into the emirate's past. Traditional aspects of the desert way of life, including a campfire witcoffee pots, a goats' hair tent, and a falaj irrigation system, are attractively displayed in the open museum. There are workshops where craftsmen demonstrate traditional skills, such as metal work and pottery, while women sit weaving and spinning.
Photo stop at Qasr al Hosn Qasr al Hosn began life in the 18th century as a coral and sea stone watchtower built by the Bani Yas tribes in Abu Dhabi. Its role was to command coastal trade routes and to protect the settlement that had grown up around the water sources they discovered on the island. One of the most ingenious aspects of the structure is its traditional 'Barjeel' ventilation system – effectively an early form of air conditioning. Recessed arches built into the exterior walls would direct the prevailing sea breezes into the interior rooms via a network of narrow airways.
Heritage Village, a traditional oasis village provides an interesting glimpse into the emirate's past. Traditional aspects of the desert way of life, including a campfire with coffee pots, a goats' hair tent, and a falaj irrigation system, are attractively displayed in the open museum. There are workshops where craftsmen demonstrate traditional skills, such as metal work and pottery, while women sit weaving and spinning.
Louvre: Louvre Abu Dhabi and its universal story embody the spirit of openness and dialogue among cultures, displaying works of historical, cultural and sociological significance from different times and civilizations. Once open, the museum's permanent collection, as well as important loaned artworks from prestigious French institutions, will form an art historical narrative taking the visitor from ancient times to the contemporary through 23 permanent galleries in 12 sequences. The 180 meter-wide dome covers the majority of the museum and becomes an iconic structure visible from the sea, the surrounding areas and Abu Dhabi city. The eight-layered dome is made up of four outer stainless steel layers and four inner layers separated by a steel structure five meters in height. The structure is made up of 85 super-sized elements, weighing on average 50 tonnes
In 1998, Sharjah was named the 'Cultural Capital of the Arab World' by UNESCO, an honor richly deserved. Sharjah has kept the spirit of its history alive by innovatively incorporating tradition into every aspect of contemporary development. More than 20 museums and heritage areas provide the perfect platform to showcase the arts, crafts, traditions, and importance of Islam in the lifestyles of the people in this most fascinating of cities.
Discover a world of knowledge with over twenty state-of-the-art museums and beautifully restored heritage areas that offer more to see and do than any other emirate. Whatever your age or interests; be it Arabian culture and lifestyle, the arts, nature, science, archaeology, the local history of maritime and flight, you will not be disappointed. Families are welcome and the museums offer a learning experience in a fun filled environment.
The tour begins with a short 30-minute drive where the places to view would be the Qanat Al Qasba, a small art, culture, leisure, and tourist area with facilities including the Maraya Art Center, Eye of the Emirates Ferris wheel, restaurants, cafes, canal with abra rides. Then continue to Sharjah Museum, one of the main institutions in the Art Area. Then continue to Central Souq also known as Blue Souq, a beautiful two-part building designed in an appealing, if flashy, Arabic style. The ground floor has mostly modern jewelry, watches and designer clothing. The tour will pass across to Sharjah corniche followed to Fish Market. Lastly, drive towards to Islamic Art Museum & Quran Roundabout before returning back to Dubai.
Lunch on own, evening free for leisure
Dinner at Al Sahara: A unique desert venue located in Dubai Heritage Vision, Just 25 minutes' drive from Iconic Burj Khalifa (28 KM). Set in 37 million square feet of undulating sand dunes surrounded by indigenous regional flora and fauna in a typical desert oasis landscape. It encompasses a Traditional souk, a Bedouin-style seating, 5-star dining experience with spectacular live Arabian Entertainments and much more. Arabian hospitality, heritage and culture, in a calm environment set in natural Reserve.
Dubai International Airport is the world's busiest airport by international passenger traffic. It is also the 3rd busiest airport in the world by passenger traffic and the 6th busiest cargo airport in the world and the busiest hub for the Airbus A380.
Important Information on Dubai:
Dubai is a Muslim city, a more modest code of behavior is required. Being drunk and disorderly in public is unacceptable, and may result in a fine or worse. Noise disruptions, bad language, making obscene gestures and showing disrespect in any way to Dubai's religion or its leaders are all forbidden and may land you in legal trouble.
Although you will see plenty of exceptions, mainly from tourists, there is a dress code for Dubai and this has been implemented as a show of respect and to avoid any offense being given. To sum it up you should cover your shoulders, cleavage, and legs above the knees and avoid really tight or sheer clothing.
Normal tourist photography is acceptable but it is considered offensive to photograph Muslim women. It is also courteous to ask permission before photographing men. In general, photographs of government buildings, mosques or military installations should not be taken.
Dubai Weather: Temperatures are at their lowest December, January, and February and then steadily climb. April is still ok but by May it's getting hot and you spend less time outdoors. June is hot and hideously humid, July, August, and September are hotter again and even more humid. Humidity levels can get unbearable reaching up to around 80-90% mid- summer


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The Dirt Forum for More Information
------------------- When in doubt, hit the gas.
So how much is your car going to be worth if no one wants race, there are no tracks to race at, and no organizations willing to sanction racing.
[This message has been edited by ratracer10 (edited February 14, 2005).]
If someone threatened to sue me they can go ahead, they are the one who hit me. They can start using street accidents if they feel that they want to handle this case as it seems they are. If I pull out and you hit me, and then I sue you for my broken arm who's the court going to go for???
Congratulation on your victory.
Don't get me wrong Xtreme, I know plenty of people in the legal system and from what little I know of you here I would guess you are more intelligent then a fair number of lawyers out there. They just have the advantage of 4 years worth of doing nothing but studying and practicing legal procedures. Also don't forget the first and most important step of a case, selecting the jury. A good lawyer will win the case over you right here before it even starts by eliminating anyone that may favor your side. Do you know under what legal precedents you can eliminate prospective jurors that might not favor your opinion or even how to identify them during selection (lawyers do)?
Besides there is no room for common sense and intelligence in our legal system. If there was would some women that spilled hot coffee in her lap be awarded millions, would a burglar that has broken into a house and hurt himself when falling down the stairs on a skate board be awarded hundreds of thousands from the home owner? And look at the floodgates that the tobacco lawsuits have opened. Now people are suing McDonalds for getting fat. Yes the last case was thrown out prior to trial, but not before it cost McDonalds outrageous legal fee to get to that point.
I'm not saying that this particular case is the end to all racing, but it could be the one that starts it. I hope it gets thrown out right from the start and nothing more is heard of it. This is not the first time something like this has ever happened and it probably won't be the last. I am just saying this is something everyone who likes racing can't afford to just ignore and say it's not me. If just one of these make it through a precedent will be set.
Yes, there are more and more big lawsuits going against car companies, and yes they are still making cars you can afford, for now. Just like at one time the US had a very good and profitable aircraft industry. Of course in 1986 Cessna, the last and only remaining general aviation manufacturer ceased production of piston aircraft. This was due to the increased cost of insurance and defending lawsuits. Not until 1994 when laws were changed to specifically protect certain manufacturers did production start to resume and companies reopen. Eight years with out new aircraft, how about eight years with no new cars. No this will never happen because more people need new cars then did planes, but how bad will it have to get before laws get changed to prevent it.
How about TEAM Aircraft Company, who has been in business for ten years. They have recently declared bankruptcy, but why? Because they won a lawsuit brought against them. Yes TEAM won and was not held liable for the injuries sustained by the pilot flying one of their aircraft. However the cost of litigation was so expensive it bankrupt the company. At least they won the case, I'm sure it makes them feel better.
Of course aircraft are complex and possibly dangerous things that only a few have anyways and can't happen with anything most people use. Something simple as a ladder can't succumb to this, can it? January 05, 2004 "The Last Rung"The nation's oldest ladder manufacturer, family-owned John S. Tilley Ladders Co. of Watervliet, N.Y., near Albany, has filed for bankruptcy protection and sold off most of its assets. Founded in 1855, the Tilley firm was profitable until a few years ago but could not handle the cost of liability insurance, which had risen from 6 percent of sales a decade ago to 29.4 percent by the end, even though the company wasn't sued often and had never lost an actual court judgment.
Ya, I guess your right. A few gold diggers and their lawsuits will have no affect on us.
Long live racing. Go Winston, oops I mean Nextel Cup Racing. Oh well, its just one sponsor that can't afford to support racing due to lawsuits.
quote:Originally posted by Xtreme12x:I'd defend myself.
That's exactly what they want, there's simply too much legal-ease to wade through and without the trained eye you'd miss something. Do you think legal writing is so complex just to show off their degrees?
Back to the Archives


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Send your email to BSNL Prepaid Punjab at the above address or you can personally visit the place on the given address.
Communicate with BSNL Prepaid Punjab through the email address displayed above for any query, help, suggestion and feedback.
Pick up your phone and call BSNL Prepaid Punjab on the specified contact number.
Open www.punjab.bsnl.co.in website and get all required information from there.
Punjab Telecom Circle is currently providing telecommunication services with all modern telecom facilities and excellent network in the entire Punjab State. BSNL offers latest services like BlackBerry, IPTV and 3G in Punjab with personal regards. G.S.Julka is the Chief General Manager Punjab Telecom Circle. Customers can get more information about BSNL Prepaid Punjab, Online Telephone Directory, Tariffs, New Services etc. BSNL Prepaid Punjab brought two new 3G plans STV120 and STV599. Bharat Sanchar Nigam Limited has two offices in Punjab - Rampura and Sector 70 Mohali, India. The BSNL Prepaid Punjab company also offer different range of tablet which include Bsnl Penta Tpad WS802C, BSNL Penta IS709C, BSNL Lofty Tab TZ-300, Bsnl Penta Tablet 703C, BSNL PENTA TPAD IS701C, Bsnl Penta IS801C, BSNL Penta WS704C.


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Very good coverage of different supervised and unsupervised algorithms, and lots of practical insights around implementation. All the explanations provided helped to understand the concepts very well.
You need to know, what do you want to get out of this course. It gives you a lot of information, but be prepared to work hard with linear algeabra and make efforts to compute things in Mathlab/Octave.
When will I have access to the lectures and assignments?
Once you enroll for a Certificate, you'll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.
What will I get if I purchase the Certificate?
When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.
What is the refund policy?
Is financial aid available?
More questions? Visit the Learner Help Center.


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PARIS Hilton thinks Britney Spears looked "cool" with no hair. The socialite - who is currently starring in new reality show "Paris Hilton's British Best Friend" - encouraged contestants in the program to shave their heads to resemble the "Womanizer" singer during her public meltdown. Paris said: "Britney looked cool with no hair." In the series, Paris is trying to find a best friend who lives in the U.K. The hotel heiress - who was at one time close to Britney - admits she finds it difficult to make friends she can really trust. She added: "I find it hard to know who I can trust. A lot of people just want to be friends with me to become famous themselves. I get used a lot." - Expo The 27-year-old star has been learning British slang in bid to impress her potential U.K. pal. She explained to Britain's The Sun newspaper: "I've been taught some slang. If you're talking about a gross guy then you say he's a minger? I like that. And if you think a guy's hot then you call him 'fit.'" - Expo
Our Staff Reporter
January 31, 2009


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Right after 9/11, everyone predicted that we would see the end of meetings, events and conferences: people would recoil in fear, stop travelling, and cocoon at home.
That was the dumbest thing I ever heard, and I said so in a column I wrote for Successful Meetings, the voice of the global meetings and events industry. Titled "Get Real," it was bang on with my of my comments and predictions.
Fast forward – technology is changing the hotel, meeting and event industry at a furious pace, and Successful Meetings just ran an article on these trends. It's a great read. But its kind of fun that they start the article with y comments on the cautious speed fo technology in the sector.
Read the intro below, and read the full article here.
7 Hotel Tech Trends to Watch
Whether it's chatbot concierges or self-check-in kiosks, hotels are getting smarter
by Ron Donoho | April 02, 2018
Robots. Facial recognition technology. Virtual and augmented reality. There's a seemingly unending stream of cool tech tools flowing out of research-and-development centers and into all corners of the meeting and hospitality industries. It's influencing hotel and event check-in processes, adding bells and whistles to guest rooms, and innovating meeting spaces. To borrow from Thomas Dolby, they're blinding us with science.
[Read more…] about Article: 7 Tech Trends to Watch: Successful Meetings


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What marketing your handmade shop and real estate have in common
You can watch the video, or read the post below.
Building on a rented land
Difference between OWNING and RENTING in real estate is quite clear for everyone. When you think about marketing, you have to remember that the same exact concept applies:
- You do not own Facebook;
- You do not own Instagram;
- You do not own Pinterest;
- You do not own Etsy;
- Ok, you get my point…
Here's what I mean exactly: when you sign up to any of those platforms, you agree to THEIR terms and conditions. You probably didn't read them – who does? They're boring, it's long and most of us don't really understand all those terms, but they all say that they can make changes to their platforms pretty much whenever they feel like it, without asking you if you're happy with it first. When those changes are minor, it's kind of okay, but when they are so big they affect your business and your bottom line, we have a problem. I'm talking Etsy algorithm changes, Instagram changes, and oh, remember when Facebook announced it will be much harder for you to reach your followers? That's kind of big news, especially if you've spent the last 5 years working hard on building your Facebook following.
When you're relying on one platform like Etsy or Facebook for your business, and suddenly the algorithm changes, it's like if someone has cut a line of communication you had with potential customers. Do we want that? No, thanks. Luckily, those things only happen if you build your business on a rented land. So, what's the alternative?
Building on your own land
Oh, you know where I am going… Email marketing! Building your email list is the BEST way to do marketing because you have direct access to your subscribers and customers and no one can get in the way and tell you "oh sorry from tomorrow you won't be able to email your list there's been a global Internet algorithm change". That's not a thing that exists. Once you have an email list with people on it you can decide when to mail them. The only way you can lose that line of communication is when a subscriber unsubscribes from your list (and that's fine, let them go!). Other than that, your email list is your most important asset and should be your absolute priority when you are thinking about your marketing.
Now, I want to be clear here:
- Am I using my Facebook page and trying to grow the number of people who like my page? Yes.
- Do I have a Facebook group? Yes.
- Do I use Pinterest to share my free resources? Yes!
- Do I use Instagram? Sure do!
The thing is, all of these things are ALWAYS secondary to growing my list. Because of that, I didn't really care when the Facebook changes were announced because I have at least 10x more people on my email list than people who like my page. So it didn't feel like it was going to be so damaging, I still had a direct line to my subscribers.
Don't get me wrong: platforms like Facebook, Instagram, Pinterest, Etsy etc. are great for your business. Should you leverage them? Yes! But don't just rent a space for your handmade business, OWN IT! Email marketing is the best way to do that and I highly encourage you to put it on your to-do list if it isn't there already.
I hope it was helpful. Let me know if you are building your email list and if you have any questions. If you need a guide on how to build your list step by step, check out my workshops on the topic:
Grow your handmade shop
access the free resource library
Unlock the library of free resources for makers and handmade entrepreneurs and receive weekly tips and freebies to help you craft a profitable and successful handmade shop!


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Coasters make a great gift. They can have a photo of a child, a vacation, or a pet. They can display a simple graphic with a motto or word or verse. So many options.
Our coasters are ceramic, set in a 4-inch mahogany frame. They come in a set of four. One design on all four coasters is $22.00. Four different designs in the set is $24.00.
Just contact us with your ideas.


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This post may contain affiliate links.
The Weekly Meal Deal this week is a delicious comfort staple at my house. When you think of a warm, filling, homemade dinner, you should think Salisbury steak. At least, you should today! That is what I made. To make it even easier, you can make this meal in the crockpot! Now I have your attention!
I had a feeling this versatile meal would make it into the lineup before long. It is so simple, and satisfying. You can make this ahead and freeze. I love to buy those cheap aluminum pans from the dollar store for that purpose. I adore cooking ahead. It gives such a sense of accomplishment to see all of the meals stacked up in the freezer ready to go. When you are making a meal for dinner, make twice as much and freeze one. Then you won't have to make the mess next time. Hmmm….I need to have a freezer cooking day soon. I haven't done that in a long time. That is a great time saver tip. Cooking ahead makes it easy to feed your family on those busy days without going through a drive through. You can feel like Martha Stewart without spending hours in the kitchen. 🙂
You can bake the Salisbury Steak in the oven, or do what I did this evening and throw it in the crockpot. I just put mine in the crockpot about 3 PM, and took the kids outside to play. We all needed some fresh air. It does a body good! I know it is cold and windy, but the poor things can only be cooped up for so long. They are ready to get out and run, and if I don't let them out they just do it in the house. So, I took them outside for sanity purposes. Kids need to get dirty every once in awhile. When we came back in the house, it smelled so yummy! I just mashed some taters, and opened a bag of salad and we were ready to eat!
That is my kind of meal. The kind that requires no attention, has easy cleanup, and everyone licks their plates clean! Oh….What's that? You want the recipe. Sure! Here ya go!
Salisbury Steak
Salisbury Steak Printable Version
- 1 lb. Lean Ground Beef
- ½ cup Bread Crumbs (seasoned) Click to see how I make my own.
- ½ tsp. Salt
- ¼ tsp. Pepper
- 1 Egg
- Small Onion diced (about 1 cup) (Optional)
- 1 – 14 oz Can Beef Broth (or half a carton)
- 1 – 4oz Can Sliced Mushrooms (Drained)
- 2 Tbsp. Cornstarch
- 2 Tbsps. Water
- 1 – Packet Brown Gravy Mix or 1 – Jar/Can Brown Gravy
Mix First 5 ingredients together and shape into patties about ¾ inches thick.
Cook patties in a skillet turning once until brown.
Remove from Skillet and place in crockpot or casserole dish.
Add onion mushroom and beef broth; heat to boiling.
Mix water and cornstarch together to make a paste.
Add to boiling mixture with a wire whisk and whisk until gravy begins to thicken.
Add a packet of Mushroom or Brown Gravy Mix and water packet calls for to gravy in skillet. Trust me, you will need the extra gravy (or you can add a jar of premade).
I then poured the gravy over the meat patties and cooked on low for atleast 3 hours.
You could also bake in oven at 350 for about 30 minutes.
Makes 4-6 servings…depending how hungry you are.
Meal Deal
Now, here is the Meal Deal. The prices and the coupon match-ups are for this week at Publix thanks to I Heart Publix. You can make this meal for much cheaper with the items from you stockpile. Remember, I bought ground beef at Winn Dixie last week for $1.99/lb, much less than the $3.49 this week at Publix. I also had everything I needed on hand, and did not need to buy a single ingredient except for potatoes.
The price listed below is if you need to buy all ingredients this week at publix.
This week you will need to buy…
(2) Shedd's Country Crock Deluxe Side Dishes, Mashed Potatoes: Regular, Garlic, or Loaded; Macaroni and Cheese; Cheddar Broccoli Rice or Cinnamon Apples, 21 to 24 oz tub, BOGO $3.59
Use (2) -$1/1 Sides PRINT
(1 lb)Lean Ground Beef, $3.49/lb
(2) Birds Eye Steamfresh Frozen Vegetables, Assorted Varieties, Including Steam Trays, 10 to 13 oz pkg, or Corn on the Cob, 4 ct bag, 50% Off (est $3.00 before sale)
Use (1) -$1/2; $.50/1 Birds Eye Steamfresh Vegetables, Rice, or Pasta, Any Bags – 02-07-10 SS
Or Use (1) -$1/2 Steamfresh PRINT
Plus Use (1)-$1/2 Birds Eye Steam Fresh Vegetables and Rice 10 – 13 oz Yellow Adv Buy Flyer (effective 3/6)
Or Use (2) -$.35/1 Birds Eye Vegetables, Any Excluding Steamfresh Varieties (Publix Coupon) Healthy Meals Healthy Kids Booklet
Bread Crumbs $1.50 (est)
Canned Beef Broth $1.00 (est)
Canned Mushrooms $1.00 (est)
1 pk brown gravy Mix $1.00 (est
Total Before Coupons $14.58
Total After Coupons $10.88
Divide by 4
$2.72 Per Person for Salisbury Steak, Mashed Potatoes, and a Veggie
You will have extra veggies, and Shedd's side!
**GLUTEN FREE DAIRY FREE** This recipe is Dairy free. To make sure it is gluten free, make homemade gravy or use a gluten free gravy mix.