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Webcast from NIH Office of Research on Women's HealthSymposium on Family Hormonal Health Webcast: NIH, Friday, October 29, 2004 Pituitary tumors are not
rare and occur in nearly 20% of adults, worldwide. Although clinically
significant, many of these tumors go undiagnosed for years. The abnormal
hormone production caused by these tumors has severe and debilitating
effects on growth, reproductive and sexual function, and neuroimmune
function. Therefore, the purpose of this symposium is to increase
awareness and scientific understanding of the all-encompassing nature of
pituitary disorders in order to increase earlier diagnosis, disseminate
knowledge of state of the art treatments, and pique interest in novel
scientific study of the pathophysiology of these disorders and their
many ramifications. Speakers included:Vivian W. Pinn, M.D.
Associate Director for Research on Women's Health, NIH
Director, Office of Research on Women's Health
Family Hormonal Health: the Broader Picture
Yvonne Maddox, Ph.D.
Deputy Director
National Institute of Child Health and Human Development
Hormonal Disease is no Apparent Impediment to Good Health
Captain Mohamed K. Shakir, M.D., F.A.C.P., F.R.C.P.
Director, Department of Endocrinology
National Naval Medical Center
Professor of Medicine
Uniformed Services University of the Health Sciences
Ian McCutcheon, M.D.
Professor of Neuosurgery
University of Texas
M.D. Anderson Cancer Center
The Pituitary Gland in Health and Disease
Sylvia Asa , M.D., Ph.D.
Professor, Department of Laboratory Medicine and Pathobiology
University of Toronto
University Health Network and Toronto Medical Laboratories
Impact of Hormonal Disorders in Childhood
George P. Chrousos, M.D.
Chief, Pediatric and Reproductive Endocrinology Branch
National Institute of Child Health and Human Development
The Transition Years: Neither Child nor Adult
Alan Rogol, M.D., Ph.D.
Professor of Pediatrics
University of Virginia
The Endocrinology of the Stress Response and Its Relevance to Depression, Anxiety, and Other States
Phil Gold, M.D.
Chief, Clinical Neuroendocrinology Branch
National Institute of Mental Health
Three Personal Perspectives on Living with Hormonal Disorders
Sharmyn McGraw, Bram Levy and Robert Knutzen
Edward Oldfield, M.D.
Chief, Surgical Neurology Branch,
National Institute of Neurological Diseases and Stroke
The Young Male: What are his Options and Choices?
Marc R. Blackman, M.D
Chief, Endocrinology
National Center for Complimentary and Alternative Medicine
A Young Woman's Hormonal World
James Segars, M.D.
Staff Clinician
National Institute of Child Health and Human Development
Hormonal Needs and Disorders in the Mature Female
Janet A. Schlecte, M.D.
University of Iowa
Surgical Treatment of Pituitary Disorders
Edward Laws, M.D., Ph.D.
Professor of Neurosurgery & Medicine
University of Virginia
Difficult Pituitary Problems: Options and Solution
Ian McCutcheon, M.D.
Professor of Neurosurgery
University of Texas M.D. Anderson Cancer Center
Moderator: Shereen Ezzat, M.D.
Professor of Medicine and Oncology
Head, Endocine Oncology
University of Toronto
What do we Know, Where do we Go from Here and What is the Future Role of Research?
Drs. McCutcheon, Asa, Chrousos, Rogol, Laws, Oldfield and Schlechte
View this Webcast (7 hours, 21 minutes)
Webcast: ENDO 2004: from Controversies in the Treatment of Obesity to the differential diagnosis of Cushing's Syndrome or Thyroid Cancer, ENDO Webcast includes a diverse array of the clinical symposia presented at ENDO 2004. This easy to view format includes slide graphics. This requires Real Player, avaliable free from http://www.real.com
Discovery Health will air Sam's show, "Mystery Diagnosis", Monday, November 15, 10PM EST More info here »
Miscarriages and Pit Tumors:
Miscarriages can be prevented by measuring hormones: Study:
[Health India]: London, Nov 2 : Doctors would now be able to predict the risk of
a miscarriage in a woman by measuring their hormones, researchers at the
University College of London claim.
According to the BBC, researchers have found that women who have lower blood
level hormones produced by the placenta face a greater risk of having a
Professor Eric Jauniaux and his team, investigated whether this hormone and
others produced by the placenta might be useful markers of early pregnancy loss
and are now hopeful that by correcting the cause of these imbalances
miscarriages may be prevented.
"If we are able to identify these clear hormone variations early enough, we
believe there is a real window of hope for the development of preventative
therapies for these patients, "Professor Jauniaux was quoted as saying.
Researchers are also hoping that correcting these [hormonal] harmonical
imbalances may lead to the development of treatments to prevent recurrent
miscarriage as well. (ANI)
Grapefruit and Medications Alert
Although grapefruit is generally healthy and nutritious, the fruit has been shown to interact negatively with a variety of medications for treating heart disease, depression, seizures, and HIV. What is it about grapefruit that may be so dangerous?
Unlike other fruits, grapefruit contains chemicals that interfere with your body's ability to break down certain drugs. This can lead to undesirably high concentrations of the drug within your bloodstream and an increased risk of developing serious side effects. While it's not known what specifically causes this interaction, scientists do know that the chemical culprits are present in all parts of the grapefruit. Negative effects can also be experienced after taking dietary supplements made with grapefruit extract.
If you are on medication for high blood pressure, high cholesterol, depression, HIV, or seizures, consult your physician about the dangers associated with eating grapefruit. You may be instructed to eliminate grapefruit from your diet.
A New Indication for Norditropin® (somatropin rDNA
.c The Associated Press
Novo Nordisk's Human Growth Hormone Now Approved for Use in Adults
Novo Nordisk (NYSE: NVO) today announced that the Food and Drug Administration
(FDA) has approved the use of Norditropin@ (somatropin rDNA injection) in adults
with severe growth hormone deficiency. Norditropin was approved by the FDA in
1997 for use in children.
Today's action by the FDA makes it possible for children being treated with
Norditropin for growth hormone deficiency to continue their treatment into
adulthood, and also allows for the treatment of adults with conditions that
result in a deficiency of growth hormone. Earlier this year the FDA approved
Novo Nordisk's Norditropin NordiFlex@, the first prefilled, multidose,
disposable growth hormone pen in the United States.
"We are dedicated to meeting the needs of individuals who require growth hormone
therapy treatment,'' said Michael Shalmi, M.D., vice president of
biopharmaceuticals, Novo Nordisk Pharmaceuticals, Inc. "This approval by the FDA
is yet another step in Novo Nordisk's proud history of innovation in the field
of growth hormone therapy.''
Growth Hormone Deficiency in Adults
GH deficiency in adults is a clinical syndrome that usually results from a
pituitary or peri-pituitary tumor or as a direct result of the surgery or
radiation used to treat the tumor. GH deficiency also occurs from other
pituitary-related disease or from a deficiency in childhood(1). The prevalence
rate of adults with GH is approximately two in 10,000 of the adult population,
with adult-onset GH accounting for approximately one in 10,000(2).
About Norditropin
Norditropin from Novo Nordisk is human growth hormone that has been
biosynthetically produced to resemble growth hormone the body makes naturally.
It is essentially identical to natural growth hormone in composition.
Novo Nordisk first produced biosynthetic growth hormone in 1985. In 1999, the
company introduced a liquid growth hormone formulation that did not require a
reconstitution or mixing procedure before injection. This was a major advance in
simplifying growth hormone therapy for patients.
Norditropin is indicated for the long-term treatment of children with growth
failure due to inadequate secretion of endogenous growth hormone and for
replacement of endogenous growth hormone in adults with growth hormone
deficiency (GHD) who meet either of the following two criteria: 1. Adult Onset
(AO): Patients who have GHD, either alone or associated with multiple hormone
deficiencies (hypopituitarism), as a result of pituitary disease, hypothalamic
disease, surgery, radiation therapy, or trauma; or 2. Childhood Onset (CO):
Patients who were growth hormone deficient during childhood should have GHD
confirmed as an adult before replacement therapy with Norditropin is started.
GHD should be confirmed by an appropriate GH stimulation test.
Norditropin should not be used in patients with known hypersensitivity to
somatropin or any of its excipients, in patients with proliferative or
preproliferative diabetic retinopathy. Growth hormone (GH) should not be used in
patients with active neoplasia and should be discontinued if evidence of
neoplasia develops. Growth hormone (GH) should not be used in pediatric patients
with closed epiphyses.
Increased mortality may occur in patients with acute critical illness due to
complications following open heart or abdominal surgery, multiple accidental
trauma or acute respiratory failure.
Deaths have been reported in patients with Prader-Willi syndrome who are
severely obese or have severe respiratory impairment. Male patients with one or
more of these factors may be at greater risk than females. Unless patients with
Prader-Willi syndrome also have a diagnosis of GHD, Norditropin is not indicated
for the long-term treatment of pediatric patients who have growth failure due to
genetically confirmed Prader-Willi syndrome.
Funduscopic examination of patients is recommended at the initiation and
periodically during the course of growth hormone therapy.
Monitor patients with GHD secondary to an intracranial lesion for progression or
recurrence of the underlying disease process. Monitor patients with glucose
intolerance closely; insulin dosage may need to be adjusted. Monitor carefully
if GH is administered in combination with other drugs metabolized by the CP450
pathway. Patients with coexisting ACTH deficiency should have their
glucocorticoid replacement dose carefully adjusted to avoid an inhibitory effect
on growth. Periodically monitor bone age in pediatric patients, especially in
patients who are pubertal and/or receiving concomitant thyroid hormone
replacement therapy.
Intracranial hypertension (IH) with papilledema, visual changes, headache,
nausea and/or vomiting has been reported in a small number of patients treated
with growth hormone products.
As with all protein drugs, a small percentage of patients may develop antibodies
to the protein. Since antibodies to somatropin have the potential to inhibit
further linear growth, only patients failing to respond to treatment should be
tested for antibodies.
The following adverse events have been reported during clinical studies in
growth hormone deficient children: headache, local reactions at the injection
site, localized muscle pain, rash, weakness, mild hyperglycemia, glucosuria and
arthralgia. Fluid retention and peripheral edema may occur.
In clinical studies with Norditropin in GHD adults the majority of side effects
were symptoms of fluid retention including peripheral edema, arthralgia, myalgia,
infection (non-viral) and parasthesia. In general, these side effects were mild
and transient in nature.
Full prescribing information for Norditropin@ and Norditropin NordiFlex@ is
available by contacting Novo Nordisk Pharmaceuticals, Inc. or visiting (http://www.norditropin.com)
Norditropin and Norditropin NordiFlex are registered trademarks of Novo Nordisk
Novo Nordisk is a healthcare company and a world leader in diabetes care. The
company has the broadest diabetes product portfolio in the industry, including
the most advanced products within the area of insulin delivery systems. In
addition, Novo Nordisk has a leading position within areas such as hemostasis
management, growth hormone therapy and hormone therapy for women. Novo Nordisk
manufactures and markets pharmaceutical products and services that make a
significant difference to patients, the medical profession and society. With
headquarters in Denmark, Novo Nordisk employs approximately 20,000 full-time
employees in 69 countries, and markets its products in 179 countries. Novo
Nordisk's B shares are listed on the stock exchanges in Copenhagen and London.
Its ADRs are listed on the New York Stock Exchange under the symbol 'NVO.' For
more information, visit novonordisk.com, or in the US, (http://www.novonordisk-us.com)
(1) American Association of Clinical Endocrinologists medical guidelines for
clinical practice for growth hormone use in adults and children 2003 update.
Endocrine Practice. Vol 9 No. 1 January/February 2003.
(2) Bryan J, Loveman E, Chase D, Mihaylova B, Cave C, Gerard K, Milne R.
Clinical effectiveness and cost-effectiveness of growth hormone in adults in
relation to impact on quality of life: a systematic review and economic
evaluation. Health Technology Assessment NHS R&D HTA Programme. 2002; Vol.
For further information please contact: Media: Susan Jackson 609-919-7776
Investors: Christian Kanstrup 609-919-7937
Copyright © 2004 Market Wire
Distributed by the Associated Press
Merck Should Have Pulled Vioxx in 2000-Study
By Tom Armitage
BERNE (Reuters) - U.S. drugs giant Merck & Co Inc. should have pulled its Vioxx
painkiller from the market four years ago because data showing it raised the
risk of heart attacks has existed since 2000, Swiss scientists said on Friday.
In a report for British medical journal The Lancet, researchers at the
University of Berne said there was substantial evidence of the dangerous side
effects of the drug by the end of 2000, but the mounting data was not analyzed
"Our findings indicate that rofecoxib (Vioxx) should have been withdrawn several
years earlier," the scientists said.
Merck did not recall Vioxx, a COX-2 inhibitor taken by about 20 million
Americans, from the worldwide market until five weeks ago.
Merck said in a statement it "was vigilant in monitoring and disclosing the
cardiovascular safety of Vioxx and we absolutely disagree with any implication
to the contrary." The company said it also disagrees with the conclusion that
the drug should have been withdrawn several years ago.
"The company could and should have made the statement several years back, when
the data we analyzed were readily available," Matthias Egger, a professor at the
university's department for Social and Preventative Medicine, told a news
Merck said the data contained in the Swiss analysis are not new and are
essentially consistent with combined analyzes of clinical trials that the
company had previously published.
The Swiss research follows newspaper reports earlier this week that Merck had
tried to fight mounting concerns about the drug's safety in order to protect
The U.S. Food and Drug Administration recently published a study estimating that
Vioxx could have caused about 28,000 heart attacks or deaths since it was
approved in 1999.
Merck's shares have slumped around 40 percent since the recall, and analysts
estimate that it could face a bill of between $10 billion and $15 billion in
The Swiss scientists performed a meta-analysis on the data, taking in results
from past studies, some of which were available on the FDA Web site. They found
that patients who took Vioxx were at greater risk even after a few months,
regardless of how much of the drug was taken.
Using 18 randomized controlled trials and 11 observational studies, researchers
saw that heart-attack risk more than doubled when Vioxx was taken.
By the end of 2000, 52 heart attacks had occurred in 20,742 patients, the
researchers said. Of these, 41 were patients using Vioxx. The increased
heart-attack risks became apparent in studies that were evaluated by external
"It could be that without independent evaluation of the data, the assessment of
adverse effects is biased so that the risks of a drug appear smaller," Egger
"We therefore recommend that all studies be carried out with independent
external data evaluation."
Drug licensing authorities should review their procedures, the study concluded,
to ensure that data released after the drug launch is analyzed for signs of side
The authors also said an independent panel of experts should investigate why
manufacturers and licensing authorities did not evaluate the data available on
Vioxx sooner.
In an editorial in the journal, editor Richard Horton criticized both Merck and
the FDA, saying they acted out of "ruthless, short-sighted, and irresponsible
self interest."
"The licensing of Vioxx and its continued use in the face of unambiguous
evidence of harm have been public-health catastrophes," said Horton.
"This controversy will not end with the drug's withdrawal."
Shares of Merck closed down 3 percent at $27.02 on the New York Stock Exchange
on Thursday.
The study was part of a wider investigation into anti-inflammatory drugs and
their side effects conducted by the University of Berne on behalf of the Swiss
National Science Foundation. Full results are due mid-2006. (Additional
reporting by Deena Beasley in Los Angeles)
Speakers included:
By AVA THOMAS BENSON, Associated Press
LITTLE ROCK - Arkansans especially at risk from
the flu — but who haven't been able to get a flu shot this year because of a
vaccine shortage — may get the protection they need from 80,000 more doses of
the flu vaccine being sent to the state.
The additional doses will be ready for distribution by next week, state
Health Department officials said Monday.
Arkansas originally received only 114,850 doses of the vaccine. Health
department officials sent 48,640 to nursing homes and the remaining 66,000 to
each of Arkansas 75 counties for distribution to the state's at-risk population,
estimated at more than 420,000. Clinics around the state began administering the
shots Wednesday, and officials said fewer than 4,000 of the original shots are
The state had asked the federal government for more doses of the vaccine, but
did not know if it would receive the doses.
"We just couldn't believe it," health department spokeswoman Ann Wright said.
"We thought we might get more vaccine, but 80,000 doses is just wonderful, great
news. We're just thrilled to death."
Wright said the additional vaccines would be sent to health clinics
throughout the state for distribution and that details of how the shots are
administered would likely be left to individual clinics. The department still
plans to restrict the shots to those in at-risk categories, she said.
"(The extra doses) are for people in the high-risk groups so they've got
protection. They can really go into complications from the flu and (Arkansas
receiving the extra shots) is such great news for them."
People in high risk categories include anyone 65 years of age or older,
children younger than 2 years old, pregnant women and people with certain
medical conditions.
It takes about two weeks for immunity to develop after a person receives the
shot and the shot's effectiveness lasts for about three months.
The supply of flu vaccines was cut nearly in half this year when British
regulators stopped production at one of the two companies that provide the U.S.
with its vaccines. Officials said the flu vaccines produced at the
Liverpool-based Chiron Corp. had become contaminated.
BOSTON - Massachusetts is getting more than
262,000 additional doses of flu vaccine, which state Public Health Commissioner
Christine C. Ferguson said should be enough to vaccinate people most at risk of
death or serious complications from the flu.
However she said healthy children older than 2 and healthy adults younger
than 75 will not yet be able to be vaccinated.
"What we don't know at this point is how many additional doses might be
available in the state over the course of the next month, month and a half, over
and above the 1.2 million that we are currently counting on," Ferguson said at a
news conference Monday.
Contamination concerns at a British plant wiped out nearly half the U.S.
The state Department of Public Health said it
will receive the additional 262,630 from Aventis Pasteur, the lone remaining
maker of vaccine for the U.S. market. That brings the state agency's total to
660,000, and roughly 600,000 flu shots have been shipped directly to doctors'
offices and hospitals by Aventis.
The new doses will be sent to local boards of health, doctors' offices and
Local boards of health placed their orders based on last year's demand, which
is estimated at less than half of those who were at high risk, health
authorities said.
"We're trying to meet a heightened demand, because a lot of people weren't
coming forward in previous years," Ferguson said.
Flu season typically peaks in January or February, and only one case in the
Greater Boston area so far has been reported.
Each year, about 800 Massachusetts residents die of complications from the
Your patients may qualify for research
studies in the Neuroendocrine Clinical Center, Massachusetts General
Hospital, Boston, MA 02114. We are currently accepting the following
categories of patients for screening to determine study eligibility.
Depending on the study, subjects may receive free testing, medication
and/or stipends.
Newly diagnosed
acromegaly patients
preoperative medical treatments
Dr. Laurence
Patients with
acromegaly requiring medical therapy
Evaluating two
different medical therapies
Karen Szczesiul,
Patients with
history of cured acromegaly and current hypopituitarism
GH effects in patients with history of cured acromegaly and GH
Dr. Catherine
Dr. Anne Klibanski
Patients with
hypopituitarism (panhypopituitary or partial hypopituitarism)
deficiency/replacement studies
Dr. Beverly M.K.
Dr. Karen K. Miller
Women with
anorexia nervosa
New hormonal
Dr. Karen K.
Dr. Anne Klibanski
Adolescent girls
with anorexia nervosa
Evaluating bone
density and the effects of estrogen replacement
Dr. Anne Klibanski
Dr. Madhu Misra
Women with
hypopituitarism, ages 18-50
replacement therapy study
Dr. Karen K.
HIV positive women
with weight loss or fat redistribution
testosterone therapy
Evaluation of bone loss
Evaluation of cardiovascular risk markers
Dr. Steven
HIV positive men
and women with fat redistribution
treatments to redistribute fat
Determination of growth hormone levels and efficacy of GH
Novel lipid lowering therapy
Dr. Steven
Dr. Colleen Hadigan
Dr. Polyxeni Koutkia
Dr. Roberto Salvatori at Johns Hopkins has received a large grant from NIH to study the
consequences of lack of growth hormone and it's affects on heart function, bone density, muscle strength, and fat metabolism. It is a wonderful study but he has run into a problem with a delay in
receiving the funding. It apparently had to go through the Brazilian Gov. which is where the study will take place in a population of dwarfs that genetically have no growth hormone (a perfect study sample).
Receipt of the funds may be delayed anywhere from three to six months.
Your patients may qualify for research
studies in the Neuroendocrine Clinical Center, Massachusetts General
Hospital, Boston, MA 02114. We are currently accepting the following
categories of patients for screening to determine study eligibility.
Depending on the study, subjects may receive free testing, medication
and/or stipends.
The study began July 1 and an Endocrinology fellow, Dr. Danilo Fintini from Italy, was hired to do the research and begin July 12th, however there are no funds available yet to pay him. NIH grants require that the work be completed within a framework of time. To delay the project may cause a loss of the grant.
Any donation is tax deductible and greatly appreciated. $11,210 will be needed for the first three months and then another $11,210 for the next three months. This research when completed will help patients that are hypopituitary be treated with greater knowledge of the problem and insights in to how to help them recover strength, normal heart function and fat metabolism.
For more information about this study and Dr. Salvatori, in Word format:
please click here to download.
Thank you for your consideration in this matter. Please do not
hesitate to ask for more verification or information about the project. I look
forward to hearing from you soon.
We welcome your articles, letters to the editor, bios and
Cushing's information. Submit a Story or Article to
either the snailmail CUSH Newsletter or to an upcoming email
newsletter at
To add or
edit your bio,
please click here »
Connie has steroid induced (iatrogenic) Cushing's brought on
by injections of DMSO and Kenalog
Richmond, VA
Izzy had Pituitary Surgery January 1, 2004 for a 15mm ACTH-producing
Woodside, NY
Jo Ellen V
(room17teacher )
room17teacher (Jo Ellen V) is scheduled for transphenoidal surgery the day
before Thanksgiving, 2004. She also has empty sella
Julie C
Julie C is not yet diagnosed.
Marit is not yet diagnosed.
Saskatoon, Canada
Merlenna is not yet diagnosed.
currently living in Dixon, California
but plans to move back to Hawaii
Sharon K
Sharon K was diagnosed with Cushing's disease in Nov. 2003 and pituitary
surgery on August 13th, 2004
Austin, Texas
• If you've been diagnosed with Cushing's, please
participate in the
Cushing's Register »
The information you provide will be used to create a register
and will be shared with the medical world. It would not be used
for other purposes without your expressed permission. Note:
This information will not be sold or shared with other
Lynne Clemens, Secretary of
CUSH Org is be the
person responsible for the creation of this register. If you
have any questions you may contact her at
firstname.lastname@example.com. You
do not have to be a member of CUSH to fill out this
questionnaire, as long as you are a Cushing's patient. We do not
believe that the world has an accurate accounting of Cushing's
patients. The only way to authenticate accuracy is with actual
numbers. Your help will be appreciated. Thank you."
December 4, 2004, UCLA Pituitary and Neuroendocrine Program and Harbor-UCLA Pituitary Center present a Second California Pituitary Conference in Beverly Hills, CA. More info and registration here »
January 28, 2005, Pituitary Update Conference For Patients And Physicians. More info here.
More upcoming local meetings are listed here »
Sign up for notification of local meetings. You need not be a CUSH member to participate.
Online Chats:
Please join us in the Chat
Room TONIGHT at 9 PM Eastern.
The new chatroom is available through http://www.cushings-help.com/chatroom.htm. Since this is our own room, you won't need to go into another area after first logging in. You'll be right there! The very first time you go in, you will have to register for this chat. Although you may use your user name and password from the message boards, you will still need to register those before being allowed into the room. This room is always open, and has convenient links so that you can get needed information while you're chatting.
I hope to see you tonight!
Cushing's Help and Support at
Cushing's Message Boards at
Subscribe and Unsubscribe: Cushing's Newsletters and Chat
January 28, 2005, Pituitary Update Conference For Patients And Physicians. More info here.
More upcoming local meetings are listed here »
Sign up for notification of local meetings. You need not be a CUSH member to participate.
Online Chats:
Please join us in the Chat
Room TONIGHT at 9 PM Eastern.
The new chatroom is available through http://www.cushings-help.com/chatroom.htm. Since this is our own room, you won't need to go into another area after first logging in. You'll be right there! The very first time you go in, you will have to register for this chat. Although you may use your user name and password from the message boards, you will still need to register those before being allowed into the room. This room is always open, and has convenient links so that you can get needed information while you're chatting.
I hope to see you tonight!
Cushing's Help and Support at
Cushing's Message Boards at
Subscribe and Unsubscribe: Cushing's Newsletters and Chat
More upcoming local meetings are listed here »
Sign up for notification of local meetings. You need not be a CUSH member to participate.
Online Chats:
Please join us in the Chat
Room TONIGHT at 9 PM Eastern.
The new chatroom is available through http://www.cushings-help.com/chatroom.htm. Since this is our own room, you won't need to go into another area after first logging in. You'll be right there! The very first time you go in, you will have to register for this chat. Although you may use your user name and password from the message boards, you will still need to register those before being allowed into the room. This room is always open, and has convenient links so that you can get needed information while you're chatting.
I hope to see you tonight!
Cushing's Help and Support at
Cushing's Message Boards at
Subscribe and Unsubscribe: Cushing's Newsletters and Chat
Sign up for notification of local meetings. You need not be a CUSH member to participate.
The new chatroom is available through http://www.cushings-help.com/chatroom.htm. Since this is our own room, you won't need to go into another area after first logging in. You'll be right there!
The very first time you go in, you will have to register for this chat. Although you may use your user name and password from the message boards, you will still need to register those before being allowed into the room.
This room is always open, and has convenient links so that you can get needed information while you're chatting.
I hope to see you tonight!
Cushing's Help and Support at
Cushing's Message Boards at
Subscribe and Unsubscribe: Cushing's Newsletters and Chat


text:
Reply To: Day Four & SO Sick at night-HELP!
Home › The Candida Forum › Candida Questions › Day Four & SO Sick at night-HELP! › Reply To: Day Four & SO Sick at night-HELP!
I didn't get any molybdenum..I didn't even know what that was.. I had to look it up. My doctor had me kind of skip the cleanse..she put me on something..and told me to drink A LOT of water..I did that. So basically started with the strict diet. Cut EVERYTHING out that I was supposed to. I was really sick for like 5 days. But now that I am eating more I feel better.
I have to share this.. So I got a food processor to help me out with this diet.
I got Buckwheat Soba Noodles..yum..
Food Processor:
I put in two handfuls of basil
1/2 cup organic coconut cream
1 garlic clove
1/2 avocado
salt and pepper
Blend it all together..and it makes enough for about two servings
Delicious!! You can add chicken and/or veggies too! Yum
The hardest part for me is probably the no fruit right now..I love fruit!! 🙁

subset: commoncrawl


text:
Mayor John Lee- Understanding Las Vegas
From the time he confused into Las Vegas at age six, it's been a poor angel action for the top end. In his adolescent years, this allotment of boondocks was admired as poor people's town. Late into his chief school, the angle adapted to accepting admired as an breadth that was top in abuse and gangs. Sadly, these damaging perceptions abide decades on as the breadth is accepted as a budgetary disaster. From Lee's position as a above senator, his accepted abode as ambassador meant accepting a city-limits with abundant problems in order. It had been in a moment if apartment bazaar blast and recession were the in point. Associations with unions were decrepit and at the border of breaking.
Despite these difficulties, it had been Lee's acceptance he may about-face issues about and bear activity appear the breadth of Las Vegas. This was a city-limits he was amorous about accepting the atom that he became and accomplished his apron in chief top academy not apathy that his aboriginal application was aural the aforementioned town. This acceptance of axis things about came from the actuality that Lee had abundant acquaintance from his antecedent role as a agent as able-bodied as accepting an buyer of two acknowledged businesses. This agog abstraction could not be disputed, as affection was all he had a charge to shine. A few questions for the ambassador appear a lot added acknowledgment for what he had in apperception about axis issues about for your good.
If asked about the action for his aboriginal year in office, the ambassador appear that he was added because authoritative a beginning acceptable angel for your breadth while accomplishing actual desires that humans had. This would beggarly ambidextrous with activity issues and aperture up spaces that were ahead bankrupt for one acumen or another. Desire to is consistently to accomplish a brace of added added hours afore the angle of positivity is reached. Their ideal depended on the allotment of eliminating any blend and disturbances as these would arrest his cold of demography the city-limits advanced hence, they had to go.
The ambassador absitively that the few credibility bare to be adapted in the accident the abridgement was to alteration while in the appropriate direction. He believed that there was assurance on accurate balance to go up. The actuality the law acceptable his aggregation to plan able-bodied with altered department's assets fabricated it accessible to use accustomed funds for improvements. There is a cogent advice in the guides as able-bodied as the actuality was that over 50 percent of the city-limits wasn't advised appropriately abrogation a abundant accord of accustomed area to become activated for advancement. Obviously there was a lot that the ambassador had prepared.
Resource: try this out


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You can never prepare for a surprise animal attack. When a dog bites, you are suddenly thrust into a world of pain, medical bills, and uncertainty.
To help you through this difficult time, we have simplified the process of getting compensation for a St. Louis dog bite injury to the following four steps:
1. Identify the dog and owner
Frequently, a dog bite occurs from an animal owned by someone you already know. If that's the case, it will be easy to identify the dog and owner. If the dog was a stranger to you, then you will want to get the name and phone number for the owner, as well as information regarding the dog's breed, rabies shots, and any other pertinent information.
2. Contact the authorities
When a dog bites you, one of your first steps should be to file a police report to document the injury. This official record will help you when it comes time to pursuing compensation for your injuries. A police report filed weeks after the incident is still better than one never made. Local ordinances may also require you to contact the nearest animal control facility or public health department.
3. Get medical attention
Delaying treatment of a serious injury will only make it worse. Get the treatment you need immediately and worry about paying the bills later. Be sure to take photographs of the injury, too, and keep track of all your medical bills so that you will have the evidence you need to pursue a Missouri personal injury claim when you are ready.
4. Request compensation
When you've been injured in a Missouri dog attack, you deserve compensation for your physical injury as well as your pain and suffering. You may try to pursue a personal injury claim on your own, but for best results you should consult with an attorney who can help you get the full amount of compensation you deserve.
For help in recouping damages, talk to an experienced Missouri dog bite attorney today. Call Alvin Wolff at 877-241-1020 to set up an appointment or request your FREE copy of The Guide on How to Pick a Lawyer.


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If you like cauliflower but avoid planting it because you think it's too much work-think about giving it a try. Cauliflower is no harder to grow than most other vegetables. In fact, if you can grow cabbage, you'll have no trouble with cauliflower. The best known are the Snowball varieties . Burpeeanna and Snow Crown are good varieties. There is a purple head cauliflower that has the advantage of not requiring blanching, but many people say that it tastes more like broccoli than cauliflower. Cauliflower grows best during periods of cool temperatures. There are several reasons why cauliflower can be tricky to grow in a home garden - most of them due to environmental factors. Too much heat prevents the cauliflower head from forming. Cauliflower must be grown at a continuous, steady rate through it entire life, from seedling to harvest. Anything which slows or stops its growth, such as insects, lack of water, or excessive heat or cold, causes them to pout and may prevent development of the head. So the secret is in the timing. You can grow it either as a spring or fall crop, but in most areas of the country, you'll have better success if you plant it during midsummer for early fall ripening. Cauliflower likes a free draining and heavily manured soil which has been limed. You can directly sow cauliflower seeds into their bed or into seed starting mix. Seedlings are transplanted out into the garden after they've got their first two true leaves. Harden-off the transplants before planting them in the garden. About 5 days to a week before planting, set them outside in the shade and gradually expose them to longer periods of sun. Plant the young transplants in the garden on a cool, cloudy day or late in the afternoon. Cauliflowers take up a lot of space so leave at least two feet between plants. Cauliflowers need the same garden care as their brassica brothers, the cabbage and broccoli. Cauliflower has very demanding nutritional needs so feed them every two weeks with a manure tea. Keep the plants well watered, especially if things start warming up. A thick mulch will help maintain soil moisture. Remember to water the soil, avoiding the white head. Never let anyone tell you that it's impossible to grow cauliflowers in containers. You can because I've done it in the past. Just make sure you use a mini cauliflower variety, and give them plenty of space for their roots. When the white cauliflower head starts developing you'll need to protect it from the sun and rain. Tie two leaves together using rubber bands or clothes pins. This will blanche the head. Otherwise it goes brown. Tie bigger leaves together as the head grows. When it comes to pests watch for caterpillars and spray every 10-14 days with Bt (Bacillus Thuringienis - Kurstaki). Don't forget to reapply if it rains. It usually takes around 3-4 months for a cauliflower to reach maturity. Harvest the head around 8 inches. heads bigger than this may discolor and lose their firmness. Pull the whole plant from the ground. Some plants may produce heads prematurely on relatively small plants. This occurrence, called "buttoning", is frustrating to gardeners. It is caused by any type of stress that interrupts the plants growth. It often occurs when large transplants, or those crowded in cell packs and flats, are planted into the garden. Setting cauliflower plants outdoors when temperatures are still cold may also be a problem. To avoid "buttoning", plant small, healthy transplants two weeks before the average last frost date in your area. In young cauliflower plants, there is a fine balance between vegetative and reproductive growth. Any stress tips the balance toward button formation. Use of resistant varieties and crop rotation are the best ways to avoid diseases. Cauliflower is related to broccoli, brussels sprouts, cabbage, and kohlrabi, so rotate around the garden so you don't plant in the same place for at least three seasons. Cauliflower may be frozen or pickled. To freeze trim off leaves and cut head into pieces about 1 inch across. To remove insects, soak for 30 minutes in solution of salt and water (4 teaspoons salt per gallon water). Drain. Water blanch for 3 minutes in water containing 4 teaspoons salt per gallon water. Cool promptly drain and package, leaving no head space. Seal and freeze. Cauliflower also may turn dark in response to iron in the water or utensils. If you have problems with frozen cauliflower turning brown, add two to three tablespoons of lemon juice to every gallon of water used for blanching.
Saving seeds can be tricky as, in most areas, cauliflower won't live over in the ground where winters are cold, and it doesn't keep in the root cellar either. Yet, like other biennials, it does need exposure to cool weather to induce seed-stalk formation. If you are determined to produce your own seed, plant the seeds in a cold frame or unheated greenhouse in early fall, no later than October. The young plants that make it through the winter can be set out 2 feet apart after the last spring frost. The yellow flowers that develop from the cauliflower head are cross pollinated by insects. Since cauliflower will cross with other members of the family, separate by at least 200 feet. Pick the seedpods when they turn brown in the fall. **********************************************************************
How to water *Water as infrequently as possible. Constant moistening of the upper layer of soil encourages plant roots to remain closest to the surface where they are vulnerable to prolonged drought and also to hoeing damage.
*Water thoroughly when you do water. Give the plants a steady soaking, enough to make the soil wet four to six inches down. Allow 2 to 4 gallons of water per square yard of growing surface (640 gallons delivered to 1,000 square feet amounts to one inch of water.)
*Get the water to the roots
*Increase the humus contents of your soil to improve its water-retaining capacity.
A freebie worth its weight in compost are those disposable chopsticks you get at Asian restaurants. You can use these handy recycles as markers when planting bulbs. Stick one in the ground over a newly planted daffodil or tulip bulb. When you plant over the bulbs with annuals, you will have a good idea how the finished bed will look. Or another use for them is planting sweet pea seeds. The diameter is just right and the seeds will tumble down a chopstick hole and settle in well. As a transplanting tool, they are unsurpassed. Use them to lift newly germinated seedlings out of the flats, and then make holes in the prepared potting mix for the small plants.You can write on them with a waterproof marker to make identification tags. How's that for versatile? I am guilty of embarrassing my friends and family at Asian restaurants by taking all the chopsticks off the plates at the end of the meal. Hey, they are just going to throw them away anyway!
Herbs Bergamot
prefers rich moist light soil in sun or partial shade, mulched in dry seasons. Sow in spring, or divide mature plants every 2-3 years ins spring. Caution: bergamot may cause photosensitivity in some people. Also called bee balm, Oswego tea, horsemint.
Bog Myrtle
grow in damp acid soils in shade, and prune in winter. Propagate in autumn from seeds sown outdoors, or from cuttings, layers or division. Also called sweet gale and sweet willow. Sweet Cicily
divide roots in spring or autumn, or sow seeds in autumn in trays outside or where plants are to grow (frost is needed for germination). Transplant while young to deep, rich, shady soil in moist location; plants self seed freely and may be invasive in heavy soils. Also called myrrh.
"Whether a three-acre farm or a downtown window box, a garden is a miraculous place - and hopefully, a joyful one."


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Wondering how to write a memoir? Think theme!
Many people pondering how to write a memoir decide it is best to put pen to paper, or fingers to keyboard, and begin writing away.
But the process of writing a memoir really should begin with a review of your stories, those amusing, dramatic, heart-wrenching or heart-warming tales you've been telling your friends or running through your mind for years.
Imagine laying your stories out on a table…
Then, pick up each one and review it carefully. What did it mean to you when it occurred? What does it mean to you now? How did it help you – or force you to – become the person you are today?
Next, mentally sort the stories into different piles according to where they occurred, how they affected you, who else was involved, how old you were, and so on. Continue to group and regroup your stories until themes begin to emerge. Possible themes include overcoming a major difficulty, finding love, surviving a loss and being changed by a relationship.
Don't push to make themes appear: just keep sifting through your stories. The themes will emerge naturally. And as they do, you will probably answer the "Am I writing a memoir or an autobiography?" question.
#1 – Select your theme
Now, mentally sort through your themes. Don't force the process; let the themes play through your thoughts as they will.
Soon enough, one of them will leap out at you. It will demand your attention; you'll find yourself thinking about it over and over again. This will become your primary theme, your memoir's through-line, the underlying idea that turns a collection of random stories into a powerful narrative.
For a more advanced discussion on developing themes, see Abigail Carter's article on "Ten Tips for Finding the Theme of Your Memoir."
#2 – Match your stories to your theme
Once you have selected your primary theme, go back through your stories and make two piles: those that work with your theme and/or naturally flow from it, and those that do not.
Be ruthless. Even if a story is a particular favorite of yours, if it doesn't fit with the theme, it will stick out like a sore thumb and take the focus away from your overall message. Put it in the reject pile.
Yes, it can be painful to let a favorite story go, but remember that your goal is to create a powerful memoir – and that requires a seamless blend of theme and stories.
#3 – Now you can start writing
When writing a memoir, taking the time in advance to settle on a theme, then matching theme and stories, will make everything that follows much easier – and the results much more satisfying.
Now all you have to do is write your memoir! If this sounds like a daunting prospect, you may want to hire a memoir ghostwriter, who can help you through every step of the process.
How to write a memoir?
For more on memoirs and working with a memoir ghostwriter, see my "Memoir Ghostwriter" page. You can also learn about different ways of working with a memoir ghostwriter by reading "How Does Ghostwriting Work? Here are 5 Ways."
If you'd like help writing your memoir…
Contact Barry Fox and Nadine Taylor, the memoir ghostwriters. Use the contact form on this page to send us a message, or call us at 818-917-5362.
To learn more about ghostwriters and ghostwriting in general, read our "What is a Professional Ghostwriter?" page.


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Facebook® has made several improvements to privacy over the last year. Here's the 1st of 5 videos on how to protect your Facebook privacy.
Note: In this video I'm using Google Chrome on a Mac.
How To Create a List
In the video I mention that you can use lists to help protect your privacy on Facebook. To create a list you:
1. Select "Friends "in the left side navigation from your home page.
2. Then select "Edit Friends" on top right hand side.
3. Select "Create List" on top right hand side.
4. Then in the "Create New List" window, give your list a name and then add friends to the list.


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Should a company choose a growing hungry digital company or an established one?
Should a company choose a growing hungry digital marketing company or an established one?
Marketing operations is certainly not the sexiest part of marketing, but it is becoming the most important one. With businesses unable to keep pace with evolving consumer behavior and the marketing landscape, the pressure is on to put digital marketing operations—skilled people, efficient processes, and supportive technology—in a position to enable brands to not just connect with customers but also shape their interactions.
When done well, we've seen marketing operations provide a 15 to 25 percent improvement in marketing effectiveness, as measured by return on investment and customer-engagement metrics. Yet achieving that level of improvement is elusive for many. While marketers are embarking on a wide array of "digital transformations" to reshape their operations and business models, many of these efforts are stymied by marketing's difficulty in delivering on its aspirations. For example, one recent survey found an astonishing 84 percent of marketers do not have a formal content strategy or distribution process to feed their growing bevy of marketing channels, and they lack any kind of formally managed content supply chain.1Despite this, content budgets continue to increase.
Growing digital marketing companies are better off because:
You've had a fantastic idea for a new product, piece of software or solution to a business or personal challenge that everyone has, but no one has fully solved. The idea was so good you decided to quit your day job and found a start-up and have defined your business model using the legendary Business Model Canvas and built the online revenue model to prove the idea will fly.
Maybe you just invented a mobile app that allows you to hire someone to stay in your house for when you're waiting for a parcel to b e delivered that is going to be 'The Uber of getting people to wait for parcels'. Maybe it's a website with a new photo-analysing algorithm you can submit photos of yourself to that finally answers the question 'does my bum look big in this…?'. Maybe it's a social network for cats. Whatever your idea, no matter how brilliant, you still need a way to tell people about it, but inevitably, initially budget, or rather lack of it will be an issue. You may have budget for coffee-fuelled planning or partner meetings, but not large media budgets.
But you have a tiny challenge…
The problem is that, unlike the established digital marketing companies, you may well be trying to un-seat; you don't have a marketing department. It might just be you, or you and a co-founder. Maybe if you are a bit further down the line of start-up growth, it is you, your co-founder and a couple of developers. You have to do marketing on a shoestring budget, so how can you possibly compete with the big players in the industry you're trying to disrupt?
The answer is simple, although to put it into practice it is rather complex and needs a lot of hard graft and testing. The essence of this approach is to leverage the excitement around your idea via free/low-cost platforms, using your time or those of your first employees.


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Yesterday I finished all of my house work early and decided to sit down and make something for myself. It's been a long time since I've done that. I always either give away what I make or put it on etsy. I decided it was time to make some things I've been needing! For starters...my double point needles have needed some organization since they all live in the packages they came in which consists of cardboard and flimsy plastic, not a nice home you see. So yesterday, I designed and made this:
Next I need to make a case for the rest of my double point needles!
I hope you are all having a lovely Tuesday!
♥ Anna Kristine
PS I've made one of these for the shop, you can check it out here!


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Letters to the Editor
Partner with Putin
Re Patrick Buchanan's Nov. 18 column, We teamed with Stalin, we can team with Putin: I agree with its substance. Vladimir Putin has extended his hand to the U.S. to join Russia as its ally in fighting ISIS. President Obama has declined that invitation.
History has shown that when a common enemy arises, all resources should be combined to fight that evil irrespective of who is your ally. Sure, we don't like Putin. We don't like Iran, either, but they wish to crush and destroy ISIS. In that regard, they're our allies.
Winston Churchill once said, "If the devil himself was fighting Germany, I would make a favorable reference to him in the House of Parliament." Obama should let history be his guide.
Robert A. Chitty,
Miami Shores


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Caldecott Medal and Honor Books
The Caldecott Medal was named in honor of nineteenth-century English illustrator Randolph Caldecott. It is awarded annually by the Association for Library Service to Children, a division of the American Library Association, to the artist of the most distinguished American picture book for children.
2017 Medal Winner
Radiant Child: The Story of Young Artist Jean-Michel Basquiat, illustrated and written by Javaka Steptoe and published by Little, Brown and Company, a division of Hachette Book Group, Inc.
Like Jean-Michel Basquiat's work, Steptoe's illustrations radiate energy and immediacy. A patch-worked canvas of scavenged wood, painted and collaged with photos, and images of human anatomy, evokes the improvisatory nature of Basquiat's art. "Radiant Child" resonates with emotion that connects Steptoe with Basquiat and Basquiat with young readers.
2017 Honor Books
Leave Me Alone! illustrated and written by Vera Brosgol, and published by Roaring Brook Press, a division of Holtzbrinck Publishing Holdings Limited Partnership.
At the end of her rope, Granny is desperate for time alone to finish knitting sweaters for a house filled with dozens of rambunctious children. Brosgol's expressive watercolor and cartoon art presents a genre-breaking journey taking Granny from the traditional forest setting to the mountains to the moon and beyond.
Freedom in Congo Square, illustrated by R. Gregory Christie, written by Carole Boston Weatherford and published by Little Bee Books, an imprint of Bonnier Publishing Group.
As they work throughout the week, slaves look forward to their afternoon of music, hope, and community in Congo Square, New Orleans. Christie's folk-art inspired paint and collage images powerfully capture the emotions of this little-known historical event. Vibrant color and brilliant use of line heighten the impact of the rhyming couplets.
Du Iz Tak?, illustrated and written by Carson Ellis and published by Candlewick Press.
A diverse community of anthropomorphic bugs is intrigued by an unfurling sprout. Carson Ellis deftly depicts the mysteries of life in an imaginary, natural world. Through intricate details and the witty humor of a made-up language, "Du Iz Tak?" is a treasure trove of visual and linguistic literacy.
They All Saw a Cat, illustrated and written by Brendan Wenzel and published by Chronicle Books LLC.
A cat's walk through the world becomes a surprise-filled exploration of perspective and empathy. As the feline encounters a variety of creatures, the thoughtful composition paired with spare language and repetition focuses on each individual's perception of it. Wenzel's use of a range of art materials reinforces the idea that the essence of a cat might be in the eye of the beholder.
2016 Medal Winner
Finding Winnie: The True Story of the World's Most Famous Bear, illustrated by Sophie Blackall, written by Lindsay Mattick and published by Little, Brown and Company, an division of Hachette Book Group, Inc.
Finding Winnie is an incredible account of the friendship and love shared between a soldier and the real bear who inspired Winnie-the-Pooh. Blackall beautifully interprets this multi-dimensional family story through her distinctive Chinese ink and watercolor art, capturing intimate and historical details perfect for a child's eye.
"Children will be enchanted by Winnie's journey from the forests of Canada to the pages of the Hundred Acre Wood. Blackall offers a tour-de-force of visual storytelling," said Caldecott Medal Committee Chair Rachel G. Payne.
2016 Honor Books
Trombone Shorty, pictures by Bryan Collier and words by Troy Andrews and published by Abrams Books for Young Readers, an imprint of ABRAMS.
In this autobiography, Trombone Shorty reminisces about his early life in the jazz music scene of his beloved hometown of New Orleans. Through Collier's paintings and collage illustrations, the story's authentic, heartfelt tone is masterfully realized.
Waiting, illustrated and written by Kevin Henkes and published by Greenwillow Books, an imprint of HarperCollins Publishers.
Waiting delivers an intimate story of five figurines, each anticipating the wonder of everyday moments. Using rich brown lines and a soft pastel palette, Henkes invites young readers to slow down and explore a range of emotions in a world on a windowsill.
Voice of Freedom: Fannie Lou Hamer, Spirit of the Civil Rights Movement, illustrated by Ekua Holmes, written by Carole Boston Weatherford and published by Candlewick Press.
In this biography in verse, Ekua Holmes' illustrations provide children with an intensely visual encounter with Civil Rights icon Fannie Lou Hamer. The repetition of colors and motifs within the richly layered collage create complex images that capture Hamer's power and bravery.
Last Stop on Market Street, illustrated by Christian Robinson and written by Matt de la Peña, published by G. P. Putnam's Sons, an imprint of Penguin Group (USA) LLC.
Readers are transported, along with a young boy and his grandmother, on a journey through the city. Robinson's illustrations, a colorful mix of acrylic paint and collage, feel both vintage and fresh. The diversity, vibrancy, and beauty of the urban setting are celebrated as CJ and Nana share meaningful moments together.
2015 Medal Winner
The Adventures of Beekle: The Unimaginary Friend, illustrated and written by Dan Santat and published by Little, Brown and Company, a division of Hachette Book Group, Inc.
2015 Honor Books
Nana in the City, written and illustrated by Lauren Castillo and published by Clarion Books, an imprint of Houghton Mifflin Harcourt Publishing Company
The Noisy Paint Box: The Colors and Sounds of Kandinsky's Abstract Art, illustrated by Mary GrandPré, written by Barb Rosenstock and published by Alfred A. Knopf, an imprint of Random House Children's Books, a division of Random House, Inc., New York
Sam & Dave Dig a Hole, illustrated by Jon Klassen, written by Mac Barnett and published by Candlewick Press
Viva Frida, illustrated and written by Yuyi Morales and published by Roaring Brook Press, a Neal Porter Book
The Right Word: Roget and His Thesaurus, illustrated by Melissa Sweet, written by Jen Bryant and published by Eerdmans Books for Young Readers, an imprint of Wm. B. Eerdmans Publishing Co.
This One Summer, illustrated by Jillian Tamaki, written by Mariko Tamaki and published by First Second
2014 Medal Winner:
Locomotive, written and illustrated by Brian Floca (Atheneum Books for Young Readers, an imprint of Simon & Schuster Children's Publishing)
2014 Honor Books:
Journey, written and illustrated by Aaron Becker (Candlewick Press)
Flora and the Flamingo, written and illustrated by Molly Idle (Chronicle Books)
Mr. Wuffles! written and illustrated by David Wiesner (Clarion Books, an imprint of Houghton Mifflin Harcourt Publishing)
2013 Medal Winner:
This Is Not My Hat, written and illustrated by Jon Klassen (Candlewick Press) 2013 Honor Books:
2013 Honor Books:
Creepy Carrots!, illustrated by Peter Brown, written by Aaron Reynolds (Simon & Schuster Books for Young Readers, an imprint of Simon & Schuster Children's Publishing Division)
Extra Yarn, illustrated by Jon Klassen, written by Mac Barnett (Balzer + Bray, an imprint of HarperCollins Publishers)
Green, illustrated and written by Laura Vaccaro Seeger (Neal Porter Books, an imprint of Roaring Brook Press) One Cool Friend, illustrated by David Small, written by Toni Buzzeo (Dial Books for Young Readers, a division of Penguin Young Readers Group)
Sleep Like a Tiger, illustrated by Pamela Zagarenski, written by Mary Logue (Houghton Mifflin Books for Children, an imprint of Houghton Mifflin Harcourt Publishing Company)


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Ways to Donate
...via Pay Pal
Opportunities to donate to Endeavor are available via the PayPal link below:
Endeavor, and its Foundation, Mid-Erie Foundation, Inc., are tax-exempt, 501(c)(3) nonprofit public charities, and donations may be tax deductible. (Consult your tax advisor)
...via Mail
Donations can be mailed directly to:
Mid-Erie Foundation
c/o Endeavor Health Services
Attn: Executive Assistant
1526 Walden Avenue
Suite 400
Cheektowaga, NY 14225
Attn: Human Resources Director
Your financial Support is gratefully acknowledged.
...via AmazonSmile


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Be familiar with temperature sensor
According to the output signal modes, it can be divided into 3 types: digital temperatures, logic output temperature, and analog temperature. In such experiment, the LM35 series sensors is a precise integrated circuit temperature sensor on the development of LM135. Its output voltage is proportional to the centigrade temperature linearly.
Thus the LM35 make interfacing to readout or control circuitry especially easy. The device is used with single power supplies, or with plus and minus supplies. As the LM35 draws only 60 μA from the supply, it has very low self-heating of less than 0.1°C in still air. The LM35 is rated to operate over a −55°C to +150°C temperature range, while the LM35C is rated for a −40°C to +110°C range (−10° with improved accuracy). The LM35 series is available packaged in hermetic TO transistor packages, while the LM35C, LM35CA, and LM35D are also available in the plastic TO-92 transistor package. The LM35D is also available in an 8-lead surface-mount small outline package and a plastic TO-220 package.
Calibrated Directly in Celsius (Centigrade) temperature sensors, with an output voltage linearly
• Linear + 10 mV/°C Scale Factor proportional to the Centigrade temperature. Thus the
• 0.5°C Ensured Accuracy (at +25°C) LM35 has an advantage over linear temperature
• Rated for Full −55°C to +150°C Range sensors calibrated in ° Kelvin, as the user is not
• Suitable for Remote Applications required to subtract a large constant voltage from the output to obtain convenient Centigrade scaling. The
• Low Cost Due to Wafer-Level Trimming LM35 does not require any external calibration or
• Operates from 4 to 30 V trimming to provide typical accuracies of ±¼°C at
• Less than 60-μA Current Drain room temperature and ±¾°C over a full −55°C to
+150°C temperature range. Low cost is assured by
• Low Self-Heating, 0.08°C in Still Air trimming and calibration at the wafer level. The low
• Nonlinearity Only ±¼°C Typical output impedance, linear output, and precise inherent
• Low Impedance Output, 0.1 W for 1 mA Load calibration of the LM35 make interfacing to readout or control


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Nepal in the Mahabharata Period, Part 20
Phewa Lake - Pokhara, Nepal
The Mahabharata Range (left to right): Annapurna IV, Annapurna II, Lamjung Himal
Sri Krsna's liberation of Banasura, the Yadava dynasty's presence in Nepal, and the events that preceded and followed.
The Pokhara temple dedicated to the worship of Bhima, featured in our last segment, is situated in an ancient city along the Annapurna range of the Himalayas. Pictured above is Phewa Lake in Pokhara, with a backdrop of three famous Himalaya peaks.
Our series, 'Nepal in the Mahabharata Period', wouldn't be complete without a discussion of the Himalayan mountain range named after it -- the Mahabharata Range. Also known as the Lesser Himalaya, the Mahabharata Range is a major east-west range with elevations from 5,000 to 9,000 feet (1,500 to 2,700 meters) along the crest. The Mahabharatas parallel the much higher Great Himalaya range, which runs from the Indus River in Pakistan across northern India, Nepal, Sikkim and Bhutan. From Eastern Bhutan, the two ranges become increasingly difficult to differentiate from one another as they approach the Brahmaputra River. The Mahabharata Range also parallels the lower Shivalik or Churia Range (Outer Himalaya) to the south.
The southern slopes of the Mahabharata Range are steep and nearly uninhabited, while the crest and northern slopes rise gently enough to support upland pastures and terraced fields. Nepal's densely populated Middle Hills begin along the crest, extending north through lower valleys and other "hills". Eventually the population thins out above 2,000 meters, at which point grain-based agriculture begins to give way to seasonal herding and cold-tolerant crops such as potatoes.
Most ethnic groups found along the Mahabharata Range and northward into the Middle Hills have Tibeto-Burman affinities, including peoples of Nepalese origin like the Newar, Magar, Gurung, Tamang, Rai and Limbu. However, the largest ethnic demographic is comprised of the Indo-European Hindus known as the Paharis, who are mostly upper Brahman and Kshatriya or Chhetri castes. The lower terrain, south of the escarpment, was historically known to be malarial, and was only inhabited by indigenous peoples with evolved immunity, notably the Tharu tribe.
Due to the daunting geophysical challenges to travelers, the Mahabharata range virtually isolates the population of southern Mahabharata from the rest of the local Kabhre Palanchok district.
The Mahabharata Range is an important hydrographic barrier crossed by relatively few rivers. There are numerous tributaries flowing south from the Himalaya through the Middle Hills, forming the visual 'candelabra' effect so familiar today, thanks to aero-photography. These tributaries gather together just north of the Mahabharata Range and cut through in major gorges, such as the Karnali in the west, the Gandaki or Narayani in central Nepal, and the Kosi in the east.
Kali Gandaki River, Nepal
From atop the Mahabharata Range, on a clear day the panorama offers an extraordinary view of the entire Nepal Himalayas, from Mount Everest in the east, all the way to the Annapurnas in the west. The above illustration shows a section of the eastern Himalayas, the eastern part of Rolwaling Himal on the left and the Khumbu Himal on the right. Mt. Everest is clearly visible just to the right of centre. The picture below shows the central Himalayas as observed from the top of the Mahabharat ridge. The Dhaulagiri and Annapurna Himal is on the left, the Himalchuli-Manaslu Himal is on the right. These mountains are between 200 to 300 kilometers distant from where the pictures were taken, yet they are clearly identifiable.
With temperatures persisting around forty degrees celsius in the plains of India from April until the onset of the summer monsoon in June, but ten to fifteen degrees cooler atop the Mahabharata Range, Hill Stations were developed as alternate capitals and resorts for the hot season by India's Mughal and British rulers. There are no hill stations per se in Nepal, Sikkim or Bhutan since the capital cities are high enough to avoid extreme heat. Likewise, there are none of the hill station temples to be found in Nepal, like we find in adjacent Indian states.
There is a great difference between the northern and the southern regions of the Mahabharata Range. For example, while the northern Mahabharata has a great abundance of citrus fruit orchards, virtually no fruit trees can be found throughout the southern part of the region. This is attributed to the difficult access to the southern portion of the range, resulting in an historical pattern of limited traffic, and in modern times neglect by city planners, for the same reason.
A cluster of houses on the South Mahabharata range


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Bindy The Monkey's Caribbean Cruise
After all the trips Bindy has been on, it was time for a break. When Bindy's travel agent suggested a Caribbean cruise, Bindy was skeptical. Bindy had never heard of taking a vacation from taking vacations. But in the end, the travel agent was right - a relaxing cruise was just what Bindy needed. Between relaxing on the beach in Antigua, getting into trouble at Senior Frog's in San Juan, visiting Dolphins at Tortola, and dodging planes at 'Airport Beach' in St. Maarten, Bindy managed to make a few friends on the ship, the Grandeur of the Seas. As an extra bonus, the ship even had a casino, which Bindy learned to love on the trip to Las Vegas. Cha-ching!


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- a 100% Offroad capable custom Trailer
Improved HOG-2 now available - designed to fit your requirements
to 100%!
These are only some possible variants:
basic design of the Hog-1 was preserved and optimized in many details:
you are interested in the Hog-2 please take yoour time to send us a Specification-
and RFQ-datasheet.
Note: due to the effort being spent for a detailed
quotation we charge 100,-EUR net for a detailed quote - complex specs may face
a higher charge. You will get full refund when placing an order for the quoted
trailer. Too muich for you at this stage of the project? Well, then the trailer
will be too much for you as well.
Example for our Demonstrator Hog-2 loader / dumper:
pump unit
This electro-hydraulioc pump unit will ease the usage
of your dumper. Unload with the push of a button - convient, no need to step out
of the vehicle or stop.
Standrd delivery is with a wired remote
control. Optional a R/C is available that can control a winch as well (4-channel
Duty leg support with offroad footplate
Based on a standard AL-KO support
leg we modified thias unit. It comes with a massive mounting bracket and an aggressive
offroad footplate that will literally bite into the ground. Definitely no slipping.
Additional holes provide a way to drive earth nails through for increased stability.
historical facts:
In the year 2001 a five series of this famous HOG-trailer
was initially produced. The basics behind this trailer were as follows:
The first trailers were equipped
with the box originating from the Toyota Land Cruiser HZJ79 - sometimes with cover
as shown below.
trailer is designed to give better offroad performance and ground clearance than
a HZJ78 with a heavy OME suspension. The axle is designed of being able to carry
1.4 tons as continuous load. This trailer serves behind my fellow BJ42 now
for more than 3 years under heavist professional conditions in the rocky Oberpfälzer
woods without any problems.
The following wheels and tires can be fitted: 206-16, 235/85-16,
7.5-16, 8,25-16, 9-16, 33x9.5-16, 265/75-16, 285/75-16.
tires than 235/85-16 just need a ribbon lip to be legalized in Germany. The trailer
is equipped with a 1.5m long pulling rod in case you want to transport cajaks
or other long things. You easily can shorten this rod to your desired length since
it is not welded to the frame but massively clamped.
trailer pictured is equipped with 235/85-16 tires.
clearance was 420mm.
The 2nd
generation since 2007 serves our customers' and our needs - proven in harsh envireonments
and usage since then.


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Charity concert. Russian Philharmonic and Wiener Concert Verein in Moscow
The Wiener Concert-Verein is a chamber orchestra founded by musicians of of the Vienna Symphony Orchestra in 1987. Its repertoire ranges from orchestral works of the Viennese classical composers to contemporary Austrian music. The orchestra toured in Asia and North America and participated in music festivals such as the Wiener Festwochen, the Bregenz Festival, the Menuhin Festival Gstaad, the Dubrovnik Festival, the Mozart Festival Augsburg, etc. The Wiener Concert-Verein cooperated with well-known conductors such as Vladimir Fedosejev, Krzysztof Penderecki, Christian Arming, Leopold Hager, etc. In 2005 the Wiener Concert-Verein's CD was nominated for the Amadeus Classic Award.
Alfred Eschwe studied at the Music University of Vienna majoring in violin, piano and conducting. He has frequently appeared as guest conductor in Germany (Hamburg State Opera, State Opera "Unter den Linden" in Berlin, Bavarian State Opera in Munich etc.), Italy (Teatro Verdi in Triest, Teatro Massimo in Palermo,Teatro Reggio in Turin, Teatro Filarmonico in Verona, Teatro Bellini in Catania) as well as Den Norske Opera in Oslo and the New National Opera in Tokio. In 2002, Alfred Eschwé began to conduct regularly at the Vienna State Opera. There the now famous DVD of Donizetti's "L'Elisir d'amore" with Anna Netrebko and Rolando Villazon was recorded under Eschwé's direction. Alfred Eschwé cooperates with the Vienna Symphony Orchestra, the Austrian Radio Symphony Orchestra, the Mozarteum Orchestra Salzburg, Arena di Verona Orchestra, etc. Together with the Vienna Johann Strauss Orchestra Alfred Eschwé has presented program of compositions by Strauss dynasty around the world, including Japan, the United States, South Korea, Italy and Spain.
People's Artist of Russia Yuri Rozum is a prize-winner of the II Queen Sofia International Piano Competition in Madrid (1979), the XXXI Maria Canals International Competition in Barcelona (1980) where he won the 1st Prize and was awarded Gold Medal and special prize for the best performance of Spanish composition, and the International Competition in Montreal (1984). Yuri Rozum tours a lot performing at the most prestigious venues such as the Grand Hall of the Conservatory and the Tchaikovsky Concert Hall in Moscow, Gewandhaus in Leipzig, Teatro Colon in Buenos-Aires, Palau de la Musica in Barcelona, Teatro Real in Madrid, Bunka Kaikan in Tokyo, Orchestra Hall in Chicago. Yuri Rozum performs as a soloist with the best orchestras of the world.


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by Jane Nawrocki
(Milwaukee, Wisconsin, USA)
When leaders create an environment where new ideas and appropriate risk-taking is valued, they build a trusting environment where people feel safe to share new ideas. Innovative organizations have an advantage, as continuing to innovate keeps them ahead of the competition.
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text: There is a scene in my story where the MC sees the town's main guard dog, a big black Presa canario, and is described as such. The problem is that I do not think most people know what a Presa looks like, but I don't think there is a dog that represents strength and ferociousness like this breed. Should I keep the Presa or attempt to describe a big dog?


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Our rooms
The capacity of Villa Voyta is 21 rooms and suites (42 beds). All rooms are equipped with minibar, TV, Wi-fi connection and air conditioning. These rooms may be booked as double or twin (separate beds), an extra bed is available in selected rooms. A total of 18 rooms are supplemented with Romantic suite, Family suite and Tower apartment.
The historical premises of hotel hold 12 double rooms reconstructed in Art Nouveau style. The entire hotel complex consists of a Romantic suite with terrace, hotel lobby with reception service (6.30 a.m - 11:30 p.m.), and a summer garden with an arbour.


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Bagdogra Car Rental
Bagdogra is a census town in Darjeeling district in the state of West Bengal and this town is surrounded by the charismatic charm of tea gardens, which is part of Greater Siliguri Metropolitan Area. Bagdogra is the second largest city in the state of West Bengal. Bagdogra has a railway station and a Bagdogra Airport only in North Bengal. Some places to visit in Bagdogra are:
The Science City: North Bengal Science center is home to a planetarium and a nature interpretation Centre. Our expert professional drivers are well aware of the roads and have modern amenities. By choosing our car rental services in Bagdogra, you could enjoy the sightseeing places without any hassles.
Kali Mandir: Sevokeshwari Kali Mandir is an ancient temple located very close to Coronation Bridge in Siliguri. At every point of time, be it day or night you could book also book our car rental from Bagdogra to Darjeeling.
Coronation Bridge: Coronation Bridge, also known as Sevoke Coronation Bridge was built in 1930 over the Teesta River at the confluence of Rangeet River and Teesta River to mark the Coronation of the King George V. The bridge is located close to Sevokeswari Kali Mandir in Siliguri. Our car rental in Bagdogra can be easily booked through phone or online processes.
Our expert professionals do always look for your contentment and will to deliver you the best. In order to offer you with extended solutions, we even offer the extended solution from Bagdogra airport to Darjeeling. We also have all types of car which will give you many choices and you can choose one of them according to your comfort. Our friendly drivers do have all the necessary papers and licenses that could make your journey hassle free one. Hire online cab service with driver in Bagdogra to travel stress-free and get memorable journey experience.


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Related Enforcement Actions
This matter was announced on July 6, 2007.
Related Document(s):
Press Release (NPA - USAO-SDNY)
Related Case(s):
U.S. v . Hans Bodmer: Docket No. 03-CR-947-SAS (08/05/03)
U.S. v . Clayton Lewis: Docket No. 03-CR-930-NRB (07/31/03)
U.S. v. Thomas Farrell: Docket No. 03-CR-290-RMB (03/10/03)
U.S. v. Viktor Kozeny 05-CR-518-SAS (05/12/2005)
U.S. v. David Pinkerton 05-CR-518-SAS (05/12/2005)
U.S. v. Frederic Bourke 05-CR-518-SAS (05/12/2005)
Criminal - Criminal Fraud Section
Updated June 16, 2016


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Performing: Ivan Atanasovall, Tinka Avramovál, Bára Anna Stejskalová, Antonie Dědečková
A multisensory performance for 5 audience members, about being a mother and having a mother.
We go through actions that touch on moments we have shared with our mothers and children. When did you last see some of her in yourself? Inspired by the mother figures from Kytice by K. J. Erben.
The performance is English and Czech friendly.
Tell us the street or nearest stop from where you would like to get to the venue.


text: Studio : FOWReleased : 2015Censorship : UNCENDescription : Three universes, three fantasies, one iconic heroine. See Elizabeth as you've never seen her before and embark on three sexy new adventures that span time and space, with unexpected outcomes!"Vengeance Runs Deep" takes place in Rapture, where a villainous Elizabeth out for revenge uses her feminine charms to trap the last Comstock into a deal he cannot refuse."Solitary Confinement" takes place in Columbia, where a lonely and horny Liz accidentally opens a portal to Rapture, and makes a new friend in the process."Anarchy" takes place in an alternate Columbia, where the Vox Populii are running rampant. As the flames of the revolution burn, Elizabeth is cornered and assaulted by a gang of Vox looters hellbent on making an example of the Lamb.And don't miss our special add on scene "Portal Pooch" released soon!MP4 864.7 MB


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Aïe! The sky is falling on the stock market! Already lost 2 grand today and this is supposed to be only the first of several corrections. Mind you, I can't access that account for 26 years, it being part of a self managed super fund and all, so I'm hoping it will recover by then. The stock market is a lot of fun; it's like high stakes poker where everyone leaves the table on average 20% up each year, but it's not so fun on days like today.
In other news, my kungfu school has had it's power cut due to an administrative error, so last night and this morning was spend training in the dark. Very spooky. And when you're in a room with forty other people who are breathing hard, but can't see them too well, also more than a little disturbing.
Yep, I mean literally.
I'm oh so guilty of this too.
The crazy stuff kids watch today.
I find this picture to be deeply relaxing.
Ca c'est tout.


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Blaze Bayley
As he was supposedly fired on the Ed Hunter Tour of '99, we can see that Blaze wasn't the most popular of singers. He wasn't liked as much as Bruce, probably because Bruce had been on the 11 albums before he arrived. He did contribute to some good songs recently, such as Futureal and Como Estais Amigos. He was replaced by none other than the mighty Bruce for the Brave New World album. He has gone on to form his own band, ironically called Blaze!!!!


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Pam - Fear of skiing
I was inspired into taking up hypnotherapy after having hypnotherapy for my fear of skiing. We went on a group skiing holiday to France with friends, I loved the social aspect, but found it a very lonely and frustrating time, as fearless children whizzed past me on the nursery slopes and after a few days I was very much alone during the day as my partner went with the others more experienced skiers to the higher slopes. I did try to combat my fears and initially went up to the green slope with them, but spent the rest of that day walking down feeling extremely inadequate. I spent a lot of the time in sheer panic, in tears and frustrated, so the next year I was determined to make a change. I went to a hypnotherapist and after only a few sessions embarked on another group skiing trip this time to Chamonix.
Now, I'll never be a Janica Kostelic, downhill champion, but imagine my joy when I could see them looking for me on the first morning I was already on the nursery slopes and could see my friend pointing me out to my partner screaming, 'Good grief, there she is, coming down the hill, has she had lessons?' No, hypnotherapy, I smiled to myself! I had been desensitised to the fear of the type of slopes I had met the previous year and progressed beyond that. I know if I want to progress further hypnotherapy will be instrumental in combatting my fears.
After returning from the second trip I decided to take the LCCH certificate
course and this year I'm nearly half way through the Diploma. It is quite a
voyage of discovery, I'm finding it personally theraputic and great fun. I
see my first client this Friday and look forward to helping many more people
through hypnosis, in the same way I was helped.
Juliet - Panic attacks
I came to hypnosis at a time when I knew I had to take some action to remedy earlier events in my life. My main reason for going to see him was because I suffer from panic attacks and I wanted to stop these controlling my actions and limiting my lifestyle.
Having completed my sessions, the panic attacks have not gone away but their links to everyday tasks have as I can be more rational about them. What I did come away with was a powerful feeling of being more in control of my own life, having dealt with past emotions, particularly those of guilt and sadness. As a result I feel much more liberated and at ease with who I am, and I am not carrying my injured self from long ago. I came away from my sessions feeling like my mind had been to a health farm!


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You have never seen something so bizarre as this. Young schoolgirl Yui Fujishima gets masturbated with a hitachi and while this is done she has a camera shoved in her pussy. She gets to see first hand what her insides look like when she cums.
Join All Japanese Pass for only 29.95$ 19.95$ This offer ends in:
- amadeus
- : 13min
- : 2 Aug 2013
- Exclusive video


text: Hordes io is 3D MMO browser gaming. You'll be able to play as Tank, healbot or DPS. Your job is always to grapple along with other factions. Hordes.io is within the Minecraft or Kogama style. You need to use spells and alter your talent and weapons. Enjoy and inform your buddies!


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Language Focus Unit 3 Lớp 10 Trang 38
• Grammar
1. The past perfect
2. The past perfect vs the past simple
Exercise 1. Chia động từ trong ngoặc ở thì quá khứ hoàn thành.
1. had broken 2. had done 3. had met
4. had not turned off 5. had ever seen 6. had been
7. had left 8. had moved 9. had not seen
10. had broken in
Exercise 2. Chia động từ trong ngoặc ở thì quá khứ đơn hoặc quá khứ hoàn thành.
1. has just finished - came
2. had seldom traveled - went
3. went - had already taken
4. Did ... manage - had ... gone - got
5. had just got - phoned - had been
Exercise 3. Có năm lỗi về cách dùng thì trong câu chuyện sau. Hãy tìm ra rồi sửa lại cho đúng.
While George was reading in bed, two thieves had climbed —> climbed into his kitchen. When they had entered the house, they went into the dinning room. It was very dark, so they had_turned —> turned on a torch. Suddenly, they heard a voice behind them. "What's up? What's up?" a voice had called out —> called out. The thieves dropped the torch and ran away as quickly as they could.
George had heard —> heard a noise and came downstairs quickly. He turned on the light but he couldn't see anybody. The thieves already went —> had already gone. But George's parrot, Henry, was still there.
"What's up?" he called.
"Nothing, Henry", George said and smiled. "Go back to sleep".
Tham khảo đáp án đầy đủ tại đây: People's Background


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Sebastian C. Watt
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Sebastian joined Reed Smith in 2017 as an associate in the State Tax Group.
- Pennsylvania State University, The Dickinson School of Law, 2013, J.D., magna cum laude, Woolsack Honor Society, Penn State Law Review
- University of Mary Washington, 2009, B.A., Political Science, cum laude
- Pennsylvania
Notable Quotes
- 17 Jan 2018 "Sales Tax Collections Hanging on Mass. Rule, SCOTUS Ruling" The Boston Globe


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Our Health is one of the most important areas of live. In January a consultation was launched on the future provision of health care locally. This had a very large number of people engage in the consultation. The results of the consultation have been used to refine the method of local delivery.
This is now being consulted on for the next 7 weeks.
Please look at the consultation and input your views and thoughts at YOURCAREYOURWAY link


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|CCA Officers
Share |
Below are the 2016-2017 Officers and Directors of the Connecticut Chiropractic Association elected and inducted on Tuesday, September 27, 2016 at the CTChiro Annual Membership Meeting in Bridgeport, CT.
CCA officers and directors are uncompensated volunteers of the association who provide their time and services for the benefit of patients and providers.
These providers are dedicated to the mission of the CCA and its members.
CCA Executive Team: Officers and Directors
5/18/2019 » 11/17/2019
Orthopedics and Neuromusculoskeletal Medicine 2019
6/8/2019 » 6/9/2019
Dry Needling Certification


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§ Title of the Site §
6/22/2001 17:28
This kind of looks like a monopoly card the more that I look at it. I can't remember which one it is. I used to like getting the green ones, but I still can't remember what it was called as a sit here typing. I guess I just won't remember what it was.
Okay, ya got me
6/22/2001 17:51
I took this news format from Artwiz and his tweedy design - at least the title in bold and the date below it in a lighter color text. I kind of like how it looks though, which is why I used it.
» Home
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For those of you who are avid readers, you may remember that I mentioned getting to design my own pair of Sven clogs....Well, the day has arrived (well, it will be Sunday)!
I get to go to the factory, meet the owner, meet the marketing superstar (Lisa), and get to design my own pair! I may even walk out with them on Sunday!
I will be sure to document the whole day and get back to you all!
For now, here is their website (they also make clogs for some high end brands that I'm not sure I can tell you about):
Here is a pic of a direction I might go!
Have a great weekend (again)!
Lisa B