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The Summer holidays are ending and we are packing away the camping gear and getting the school bags ready, though we'll still be heading outdoors whenever we can.
The National Trust have made a list of 50 things to do before you're 11 and three quarters. After this Summer our sons are well on the way to checking them off. The list starts with climbing a tree, camping in the wild and making wild art, includes catching a crab, star gazing, building a den and finishes with learning to ride a horse and canoeing down a river. The list is an inspiring reminder of the importance for all of us to make time to explore and adventure outdoors. Research from UCLA has shown that exercise enhances neuroplasticity by stimulating growth of new connections between cells in important cortical areas of the brain.
Being in nature inspires a sense of wonder and eases the stresses of our busy daily lives. I'd like to make going on a walk barefoot my next item to check off, even though I'm a bit older than eleven and three quarters.


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Universal Access and Design
Access for all, regardless of age, ability or status.
The aim of universal access and design is to simplify life for everyone by making environments, products and services equally accessible, usable and understandable. It emphasises user-centred design and extends beyond issues of accessibility to buildings and public spaces to policy-making and planning regarding all aspects of society, including communication, information technology, goods and services.
The aim of this research program is to coordinate and support interdisciplinary research that focuses on ways in which products, processes, services, systems, environments and information can ensure access for all, regardless of age, ability or status.
This research program is led by Professor Jeannie Paterson and Dr Andrea Cook.

subset: commoncrawl


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Recital on the Rieth Chamber Series at Goshen College (IN). I'm excited to return to my alma mater with my friend and colleague, pianist extraordinaire Phillip Bush. The music will include new works by Caleb Burhans, Carl Schimmel, and Stefan Freund.
Back to All Events
Earlier Event: March 11Alarm Will Sound: Steve Reich's The Cave
Later Event: March 24Southern Exposure: Third Coast Percussion


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8. Excuses
Everyone messes up every now and then, but narcissists give flimsy excuses rather than actually following through with promises. When their actions don't match up with their words, they shrug and say they weren't really thinking about it. You'd be humiliated if you broke a promise, but they are emotionless and it simply isn't a serious problem to them, even when you point out that they are destroying the all trust in your marriage and that the marriage can't survive without trust. They know that, but it's irrelevant, whereas once, it was extremely important to them…but that's long gone. You are disappointed so frequently that you can't feel relieved when they do something decent—they condition you to expect to be disappointed again and again, and you are. All happiness is temporary, and just a short reprieve before another inflicted hurt.
9. "What in the world just happened?"
These conversations leave you drained. You may be left with an actual headache, but definitely a sense of total frustration. You will spend hours, even days, thinking over the argument you've just had. You'll feel as if you exhausted all of your emotional energy to accomplish absolutely nothing. Even if you have well thought out arguments in your head, you can never respond to all the deflections, accusations, personal attacks, and asides that make your points get lost and become irrelevant, so you try again and again to bring the conversation back on track. You will feel the need to defend yourself and much of the time is spent in this way. You can tell the narcissist isn't really listening, they just want you to shut up so they can go back to doing the same thing and ignoring what you said. You'll try to come up with a diplomatic solution, and you admit that you have been wrong at times.


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Your e-mail is required to ensure the proper functioning of the Website and its services and we make a commitment not to reveal it to third parties
Deborah Sheldon's Thylacines was published by Severed Press in January 2018.
Information about Deborah Sheldon:
Deborah Sheldon is an author of dark fiction and crime and is based in Melbourne.
Her fiction has appeared in various magazines such as Quadrant, Island, Aurealis, SQ Mag, and Midnight Echo, as well as in many anthologies. Latest releases, all traditionally published, include the horror novel, 'Devil Dragon', the crime-noir novellas, 'Dark Waters' and 'Ronnie and Rita', the crime-themed collection, 'Mayhem: selected stories', and the horror collection, 'Perfect Little Stitches and other stories'. Other credits include TV scripts; stage and radio plays; feature articles; non-fiction books; and award-winning medical writing.
Click here to visit her official website.
Information about Thylacines:
The Tasmanian tiger, or thylacine, was hunted to extinction some eighty years ago. Now, Professor Rosie Giuliani and her staff at The Resurrection Lab have done the impossible: created a living, breathing litter from a preserved specimen. Yet Rosie can't share this scientific breakthrough with the world. The cloned animals are more like monsters than thylacines. By chance, a small band of activists hears about the caged litter, and their decision to free the tigers will unleash a deadly havoc upon the campus of Fraser University.


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or complete the form below and a Coverage Coach will call you.
Living with diabetes can mean added challenges - but getting life insurance shouldn't be one of them. John Hancock life insurance with Vitality rewards you for your healthy lifestyle and the things you already do to manage your diabetes. You can save up to 15% on the cost of your coverage and earn rewards and discounts for exercising and eating well.
Jen, a 35-year old living with diabetes and the mother of two children, pays $49.62 per month for $250,000 in coverage in the first year.* As she completes healthy activities, she earns points toward her Vitality Status plus additional savings on her cost of coverage, rewards and discounts.
Meet Gordon F., an IT manager of a small equity firm in San Mateo, California, who was diagnosed with diabetes five years ago. A self-professed problem solver, Gordon was determined to figure out how to control his condition and explore ways to provide financial protection for his family, so he would be prepared for whatever the future held.
We follow a personalized and holistic approach when it comes to working with people living with diabetes. We consider lifestyle, preventative care and treatment plans to create a profile for each person that will help us provide a life insurance solution that best meets their needs.
Our Coverage Coaches are licensed life insurance professionals who can provide comprehensive assessments and real solutions for people with diabetes. Learn more about the topics they may discuss during your free consultation.


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TOKYO (Reuters) - U.S. President Donald Trump and Japanese Prime Minister Shinzo Abe confirmed in phone talks that they would step up pressure on North Korea in cooperation with South Korea, a Japanese government spokesman said on Monday.
The bilateral talks were aimed at confirming close cooperation among the United States, Japan and South Korea before a Group of 20 summit meeting to be held in Hamburg, Germany, later this week, the spokesman said.
(Reporting by Takaya Yamaguchi; Writing by Kaori Kaneko; Editing by Chang-Ran Kim)


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Sponsored by http://www.mierce-miniatures.com
Thanks for all the great feedback on last weeks show. Whilst Bishmeister was a legend, the episode was also made by all the listener questions, so once again thanks so much.
This week I am joined by former TBS host Matt Lyons as he discusses his plans to compete head to head with Steve Foote for #SCGT2017coolest – use the hashtag to see their progress and join in with them.
I'd love to hear from you if you have any feedback or ideas; the show e-mail address is email@example.com and my twitter is @the_black_sun. I've noticed a few e-mails coming in now, so will actually probably do a mailbag episode soon. Keep them coming.
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Ad ID: 60699 Inactive
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We have more than 500 sites nationally.
Our agents are based in Auckland, Christchurch and Wellington.


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Actor-filmmaker Kamal Haasan on Monday said he is not pressurising the government, but has made a plea on behalf of regional cinema to reduce the Goods and Service Tax rate which is currently pegged at the highest 28 per cent.
"Not pressurizing. It's a plea and SOS from regional cinema to our FM. We fear it will collapse. We request the council to do all to save it," tweeted Haasan, who had interacting with reporters here last week, urged the Finance Minister to reduce the GST rate to 12-15 per cent.
The "Vishwaroopam" actor welcomed the GST regime but said the 28 per cent tax will ruin regional cinema.
"At the present rate, I can't afford the tax and I'll be forced to quit. We should remember this is not East India Company," he had said, adding that Hollywood, Bollywood and regional cinema can't be put on the same slab.
"Film tickets across industries can't be fixed like essential services," he said.


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When building your Online Business as an internet entrepreneur, one of the most critical success factors is the acquisition of your subscribers.
Getting subscribers is in itself a special strategy which requires a simple, easy to use but professional Aweber autoresponder. In this article I'll explain the extremely easy steps of how you can send your PDF or downloadable file to your subscribers using Aweber.
There are several ways that you can choose including:
- "Hyperlinking" to a hosted URL
- Attaching the file
- Sending the PDF/downloadable file as a "Thank You Page" or
- Sending the PDF/downloadable file as the "Confirmation Success Page".
Hyperlinking a hosted PDF file
If your PDF/downloadable file is not already hosted online, you can host your PDF/downloadable file on your website or a third party site such Dropbox.
Once you have the URL for your PDF/downloadable file, you can write a word/phrase in your message and hyperlink the URL.
Attaching a file
Depending on the size of your PDF/downloadable file, you can attach the file to your message if the size is less than 1MB. If your file is larger than 1MB, you could try compressing the file using a source such as smallpdf.
Once the file is less than 1MB, you can attach the file to your message. Please note, the attachment limit is 1MB per message.
Sending the PDF download in the Thank You Page
If you'd like subscribers immediately directed to the PDF/downloadable file after they sign up on your form, sending them to your custom thank you page can accomplish this.
Each AWeber sign up form can use a custom URL for the "Thank You Page". In the Thank You Page section, add in your custom URL for your PDF/downloadable file.
Sending the PDF download as the Confirmation success page
If you'd like subscribers immediately directed to the PDF/downloadable file after they confirm your confirmation message for your list, sending them to your "Confirmation Success Page" can accomplish this.
Each AWeber list can have a Custom Confirmation Success page subscribers are directed to after they confirm. In the confirmation success page section, add in your custom URL for your PDF/downloadable file.
So, How Do I Send A PDF or Download To My Subscribers using AWeber? Just follow the instructions above. Plus you can also get your free 1 month trial of AWeber below.
I hope this article helped you . You may also want to check out my post How to Determine the Right Voice for Your Brand
If you liked this article, then please subscribe to my YouTube Channel for other Online Business video tutorials.
You can also find me on Twitter.


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BOSTON (MarketWatch) -- Oppenheimer & Co. analyst Meredith Whitney in a research note Wednesday wrote that Bank of America Corp. BAC, +0.79% Chief Executive Ken Lewis told her the company "views the dividend as safe, and is comfortable with a higher-than-normal payout ratio." Lewis is "cautiously optimistic on the economic environment, as recent 30-day delinquency data across the board has slowed its acceleration and credit losses are remaining concentrated in high-risk states such as California, Florida and Nevada," Whitney said. "Lewis continues to see a distinct divide between the troubles on Wall Street and the state of affairs on Main Street." Bank of America shares were down fractionally at last check Wednesday.
Bank of America CEO tells analyst that dividend is safe
Quote References
+0.21 +0.79%


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It was first time lucky for Justin and Cynthia Oliver when they entered the New Zealand Cider Awards and came away with a win.
The Matakana couple have produced organic alcoholic beverages for a number of years, but had never entered a competition before.
"We haven't taken our Bohemian Ciders to the general market yet, but winning an award straight away indicates to us they should prove popular," Cynthia says.
They already own and operate Free Range Wines, but saw an opportunity to enter the cider market.
"Justin works for Lothlorien Winery already and they bring in organic apples and have a proper press, so it seemed like a good idea to make some," she says.
They won the Cider with Fruit category with their Twig and Berry cider.
"We've taken some ideas from our winemaking, so that cider was done in wooden barrels to give it an oak flavour," Cynthia says.
"All of our drinks are made using wild fermentation and all natural ingredients, so they don't taste like an artificial beverage."
They currently have three other ciders in their range – Acid Drop, Tamarillo Amarillo and Original Cyn – and have produced around 6000 litres this year.
Bohemian is now one of the few remaining cider makers in the Mahurangi region, but Justin and Cynthia are optimistic for the drink's future, aiming to double their production and achieve national distribution.


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Nut Milk Bag
Nut Milk Bag
Make your own nut milk! It's cheaper, healthier and more environmentally friendly.
Soak 1 cup of nuts overnight, then blend with 4 cups of fresh water, some sea salt and vanilla. Blend for about 2 minutes and strain through a nut milk bag. It's easy!
Add To Cart


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Chivas de Guadalajara took the lead but couldn't hold it as Atlante came back for a 1-1 draw to send this Copa MX quarterfinal to a penalty shootout. The Potros completed the comeback from the spot, winning the shootout 5-3 to advance to the semifinals, while reigning cup champion Chivas was eliminated.
The hosts had several good chances to open the scoring in the first half, but the breakthrough didn't come until the 48th minute. Carlos Cisneros took the ball to the end-line before sending a low cross to the far post where Carlos Fierro finished it off to make it 1-0.
But Atlante seized one of their few opportunities to tie the game in the 64th minute. Cristian Tarragona headed home a good cross from the left to make it 1-1 and neither team could go on to break the deadlock.
With regulation ending 1-1, the game moved on to penalties. Atlante was perfect from the spot, with Paul Uscanga, Óscar Uscanga, Carlos Cauich, Alan Zamora, and Ernesto Reyes all converting for the Potros. Chivas made their first three kicks – Carlos Salcido, Hedgardo Marín, and Ángel Zaldívar- but Rodolfo Pizarro couldn't convert his.
With the 1-1 draw (5-3 shootout win), Atlante advances to the semifinals while Chivas is eliminated.


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Horse Whinnying (sound effect).wav
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(0:17) HORSE WHINNY SOUND: A loud horse neighing / whinnying at an indoor horse show arena with a big reverberant sound and mild crowd ambience. Delivered in CD quality WAV format (preview contains a security watermark tone).
If this sound effect isn't suitable, we also have a great selection of horse sounds over at our main website here: https://www.tradebit.com
This sound effect is offered for royalty-free use by https://www.tradebit.com For your one-time payment you will receive immediate download instructions to gain access to your file(s). If you would like more than one sound effect file please use the ´add to cart´ buttons. Once you have downloaded the sound effect(s) you can freely use and distribute the files inside your commercial multimedia projects such as film, TV, video, radio, theatre, Flash applications or website backgrounds etc.
This download remains the copyright property of BIG FAT AUDIO and is intended for embedded use only. You are not permitted to re-sell or offer the sound effect for free download elsewhere. If you have any queries or problems relating to your download, please contact us at https://www.tradebit.com
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Kicken mit Herz 2013
This trailer is another work I realised with director Guntmar Lasnig for the new charity soccer game " kicken mit herz 2013″ in Hamburg. The story is that the german VIP-soccer team lost their game vs. the doctors' soccer team "Placebo-Kickers" 2:8 last year. And now a few of them are sitting on the psychologist's couch, because they were traumatized by losing the match. They're hoping that it will never happen to them again and are looking forward to getting revenge on the 11th of August at the Victoria Stadium in Hamburg. All the proceeds from the ticket sales will go to the child cardiologic department of the University Clinic of Hamburg.
Thanks to the VIP cast: Jorge Gonzalez, Revolverheld, Tim Maelzer, Steffen Hallaschka, Thomas Meggle, and Thomas Helmer


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|The Naxi and Ezra Pound concept of Paradise
Ezra Pound was one of the most important American poets of 20th century. His main work, "The Cantos", composed during more than 50 years of a life devoted to poetry, is so full of symbolism and hidden meanings that since his death, in 1972, critics are wondering about the real objective of his vast work.
The relation of Pound with China goes back to the first steps of his literary career. The fascination that Chinese characters produced on him has been treated in numerous works. But hidden to the general reader is the influence that the knowledge of the Naxi world, through the books of J.F. Rock, had over the last part of The Cantos.
In a recently published book Su Jinmei (1) suggests that the theme that support the whole narrative structure of The Cantos is the search for a Confucian paradise, and the reject of a world cemented in the greed of the Western corporations.
The Naxi, in their unspoiled environment, become the living example of this paradise Pound was longing for.
"The harmony between man and nature the Nakhi community established sets against the American "trailer life", which is "non-productive / non-agricultural."
Su Jinmei, p. 107
"It seems that the Nakhi world had been dwelling in Pound's mind during the years he wrote the last cantos. The Nakhi community appears in Canto CX "it reappears in the fragment "From CXII" which depicts the Nakhi paradisiacal landscape."
Su, p. 108
"The Nakhi world with clear air, spring water, flowing "jade stream", luxuriant forest and the magnificent Mount Hsian Shan or Elephant Mountain becomes the symbol of the earthly paradise. "The firm voice amid pine wood", shows that man is but an inseparable part of the world."
Su p. 109
The idea of paradise is manifested in two Cantos that make explicit reference to the life of the Naxi. In Canto CI and CIV. Many researchers on the works of Pound have before Su Jinmei, realized the importance that the Nakhi culture had in the last part of The Cantos, but she, making the search for a Confucian paradise the main theme of the works, makes the Naxi paradise in the realization of this dream.
As one of the critics who have studied more the works of Pound, Ira Bruce Nadel (2) writes:
"He envisioned a succeeding volume of Cantos with a full treatment of the Nakhi."
Bruce Nadel (2), p 125
The pristine environment where the Naxi live, their zeal to preserve nature, the integration of men in nature, are all aspects of Naxi way of live reflected in Pound's Cantos.
(1) Su Jinmei.-
Confucianism in Pound's Cantos. Nankai University Press. Tianjin. 2003
|Back to Naxi main page
|© Copyright 2007 www.ethnic-china.com
Buy books related to China Ethnic Groups and help to develop this web


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Above: Science meets art. Credit: NASA A strong focus on combining humanities and the arts with science, technology, engineering and maths (STEM) was a strong undercurrent to the STEM...Read More
From left: Refraction founders Heather Catchpole and Karen Taylor-Brown, with Production Manager Heather Curry and Publishing Co-ordinator Jesse Hawley. Last night Refraction Media, a Sydney-based publishing start-up, was announced Australia's...Read More
Geoscience Australia and other Australian geoscience organisations will be hosting Australia's Earth Science Week celebrations and aligning activities with the international theme, "Visualising Earth Systems". Celebrate Earth...Read More
Click below to listen to a shortened version of our interview with Karen Wellington of the Fogarty Foundation and Director of CoderDojo WA:
It's controversial, counter-intuitive and research on its effectiveness is thin on the ground, yet increasingly, educators are getting excited about flipping the classroom. Why? Perhaps because the basic tenet of...Read More


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Best Online Pokies For Mobile Phone
Just a few years ago mobile pokies games were non-existent, but that has all changed now and here we are trying to determine the best online pokies for mobile phone so we can give you the heads up on what to play.
There are many online casinos where pokies enthusiasts have enjoyed numerous pokies games for quite sometime and most of them offer some type of mobile pokies games for their customers. Obviously, there are now too many to cover in one article, but we have searched for a few of the most popular online casinos the offer pokies for mobile.
Rich Casino
The Rich Casino is one of the best online pokies for mobile phone because you get 100% match bonus plus 25 free spinsas new player. They offer a vast variety of pokies games that pay real money. Not only does Rich casino offer Progressive Jackpot Pokies, but they offer great pokies games to play like Tomb Raider, Mermaid Millions, Hellboy, Lord of the Rings and Thunderstruck. They offer the latest pokies to be found from microgaming.
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Emu Casino
Emu casino offers AU$300 triple bonus. On your first deposit get a 100% match on any deposit up to $100, you'll be able to play with a maximum of $200 total. Plus you get 12 free spins on pokies and play huge online pokies progressive jackpots. They offer some of the outstanding mobile casino games designed for low end mobile phones. You can enjoy pokies machines, roulette and blackjack every where you go. It is as simple as a downloading the games you want on your mobile phone. In addition, they offer games for your iPhone or Smart Phone.
Click here to play at Emu mobile casino today!
Casino Mate
Casino Mate offers welcome bonus worth up to AUD $1400 in real money on your first four deposits. Real money gamers will also receive 80 free spins on Second Strike pokies game. They hold pokies tournaments on a regular basis and offer million dollar progressive jackpots. They offer numerous ways to pay and a wide variety of pokies to enjoy. This is the total experience when it comes to the online casino. You can enjoy playing for the best online jackpots because the casino mate is the best way.
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Fair Go
When you join Fair Go casino for the first time you are offered a lucrative welcome bonus of AUD1000. On your first deposit 100% up to $200 X5. With over 150 pokies to play powered by Real time gaming software this casino is the perfect choice to play real money pokies in AUD. Fair Go is run by the platform of Realtime Gaming (RTG) and brings a wide diversity of casino games like video poker, video pokies, classic pokies poker, table games, roulettes, blackjack, bingo & keno games to the clients with the intention to establish itself as the largest casino Australia-based punter have access to. You can enjoy pokies play online in real time with your mobile instantly.
House of Jack
When you join the casino with your mobile for the first time as a new player you are offered a welcome bonus of AUD $1000 Free in Bonuses plus 200 'Zero Wager' free spins. Being a new casino it has over hundred pokies games which are well-organised and divided into the following categories – video pokies, classic pokies, blackjack, roulette, table games, video poker, jackpot games, and 3D pokies.
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If you want to enjoy the best online pokies for mobile phone where ever you go then these online casinos can certainly have a lot to offer. You can enjoy your favorite mobile pokies game on the beach or in your favorite internet café. All of the sites we mentioned above offer excellent security and customer service support. In addition, they offer superb payment methods and too many pokies games to mention for your enjoyment.


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News from the Cambridgeshire Association
Motions submitted for NEU National Conference 2019Download motions here:Motions Booklet 2019
5 Jan 2019
Help run the NEUWe are looking for people to join our Committee. No previous experience is necessary; just a desire to help the Union in its struggle to defend state education from funding cuts and to protect teachers' pensions, salaries and conditions of service in the face of the government's attempt to dismantle the welfare state. The Committee meets twice a term. You can be nominated for one of the officer positions (see list below) or else a non-officer Committee member. Please contact the Secretary, Jon Duveen, for more details of what the jobs involve (email@example.com)Vice-President - Treasurer - Secretary - Assistant Secretary -...
15 Nov 2017
Lobby of ParliamentThe Government has announced that more money will be spent on education, but shortfalls in funding still mean that 88% of all schools are facing cuts in real terms. For the average primary school this, is a loss of over £52,000 a year. For the average secondary school, this is a loss of over £178,000 a year. Sixth Form Colleges have been subjected to even more severe cuts than schools. Parents can find out how much the funding for their own children's schools is being cut by visiting the schoolcuts.org.uk website. You will be shocked to see how much the...
18 Oct 2017
Save Our Children's CentresChildren's Centres are not just buildings! Cambridgeshire County Council is planning to cut £1m by reducing the number of children's centres from 40 to 10. The National Education Union (NUT Section) rejects these austerity cuts to our children's centres in Cambridgeshire. We call on the County Council to stand up for our communities and their dedicated and experienced workforce delivering quality early years provision. Children's centres provide universal services that enrich society by drawing communities together and averting crisis. Children's centres have become adept at multi-agency working - housing, health, social care and education. Each setting has developed its practice...
13 Oct 2017
Day of action for Nursery Schools 9th Nov 2016Great day of action accross the 6 nursery schools in Cambridge. Don't forget to sign the petition https://petition.parliament.uk/petitions/171052
10 Nov 2016
What will happen to our Children's Centres?All the major political parties seem to agree that early intervention to support children's' learning is better than trying to deal with the issues further along their education pathway. Such an approach seems like good common sense and you would therefore expect the Government and the Local Councils to operate according to this view. Not only does such an approach help children in their learning but it also is effective in the long term in saving the education service money. How then are the Government and Local Councils keeping to this view of early intervention? The answer is that...
25 Jun 2016
International solidarity - actionGarment workers for Tuba Group in Bangladesh have been on hunger strike occupying a clothes factory last month until their violent eviction by police. One of the firms largest customers in the UK is Blue Banner Max who produce school uniforms. NUT reps could send a letter to their school's uniform supplier. Model letter for school uniform suppliers
15 Sep 2014
International SolidarityCambridgeshire Association has co-opted Asim Khairdean onto its Committee as International Solidarity Officer. On the 24th May 2014, Asim attended a conference organised by the NUT: Global Education Reform: Building Resistance and Solidarity, and he has produced a detailed report. If you would like to talk to Asim about any of the issues raised in his report, please email him: email@example.com report
13 Jul 2014
Pay policy letter to Heads - July 2013The NUT and NASUWT in Cambridgeshire have sent a letter to all Headteachers setting out our requirements for any new pay policy. Head's Pay Policy letter July 2013
7 Jul 2013
Cambridgeshire Association meetings dates 2013/14GENERAL MEETINGS of Cambridgeshire Association NUT Thursday September 5th 2013 – joint NUT/NASUWT reps meeting, Holiday Inn, Histon Saturday September 21st 2013 - Rally for Education, University Arms, Cambridge Wednesday September 25th 2013 – General Meeting; nominations for GS Friday October 4th 2013 - New teachers event, CB2 Cafe, Cambridge Wednesday November 6th 2013 – General Meeting; proposing conference motions Wednesday February 5th 2014– Annual General Meeting; conference motion prioritisation February (date tbc) 2014 – Public Meeting; Education Question Time Wednesday March 12th 2014 – General Meeting; conference motion amendments June 18th 2014 – General Meeting COMMITTEE MEETINGS Wednesday September...
7 Jul 2013
Thursday 22 August 2019


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Burlington will be home to a paranormal convention this weekend: Ghostacular Paracon! It will be held on Saturday, October 1st, from 10am – 5pm, and will be at the Hilton in Burlington. The price of admission is $10.
The convention will also host some guests, such as Shannon Sylvia, who has been on Ghosthunters International. There will also be a series of workshops:
12:00PM – Bernice Kelman – Ghosts, Spirits, & Other Non-Physical Entities: Bernice will review her many years of experience helping release ghosts into the Light, as well as what she has learned from other non-physical entities. Q & A
1:00PM – Keynote : Shannon Sylvia 'as seen on Ghost Hunters International
2:00PM – Ruth Butts – Young Living Oils – Learn how to help bring balance to your chakra system – changing lives one drop at a time!
3:00PM – PI-NE – Paranormal Investigators of New England – All things paranorma. What constitutes an investigation, what happens during the investigation, & what results can be provided to client.
4:00PM – Julio Baez – Paganism 101 – Pagan Pride Day
Theatre RM B:
11:00AM – Eric Perry – Owner of Haunted Productions , Ceo of Haunted in New England and owner of CNHPS. Lecture on paranormal TV vs real investigators.
12:00PM – Michele Nappi – Mystic Medium – Ghosts I Have Met – Sharing of Experiences – Sightings – Effects Q & A
1:00PM – Keynote: Shannon Sylvia 'as seen on Ghost Hunters International
2:00PM – Ally McHugh – Spirit 101 – Learn basic protocol for connecting with spirit. Test your mediumship skills through fun, interactive exercise.
3:00PM – Christine Favreau – Labyrinth History & Development – traced back over 4000 years. What exactly is a labyrinth, and how have they developed over the centuries?
4:00PM – Tina Gilson – Basic Spirit Communication & Protection
More details here.


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Event Date(s): Jun 15 - Jun 17, 2018Event Type:
About This Event:
For the first time ever, Charles Durrett, cohousing expert and Principal Architect of McCamant & Durrett Architects, and Quimper Village Senior Cohousing are joining forces to host the Senior Cohousing Weekend Intensive on June 15, 16, and 17 in Bainbridge, WA. Set on the scenic Bainbridge Island, the weekend intensive will be a fruitful and inspiring weekend of learning from others who have successfully created their own senior cohousing community and the architect that helped them design the cohousing community of their dreams. From Friday evening to Sunday afternoon, attendees will gain tools and resources that are invaluable to anyone starting their own cohousing community.
On Saturday, participants will take a tour Quimper Village Senior cohousing and meet the residents who made it happen. Quimper Village is one of the newest senior cohousing communities in the U.S., located in Port Townsend, WA. Residents moved in in late 2017 and are already having the time of their lives surrounded by people they know and care about. Quimper Village's story is a great example of how a group of proactive people can positively impact their aging scenario.
The Senior Cohousing Weekend Intensive is open to the public but is limited to 20 people who are ready to move forward with their senior cohousing projects. Participants will hear from Quimper Village residents on "what we did, how we did it, and lessons we learned." As opposed to a larger conference, participants will be in a small group setting for the entire weekend and will get personalized, professional advice on how to start a senior cohousing community in their town. Discussions will include valuable lessons on how to make sure they're cohousing project is built on time and within budget.
Date: June 15 (evening), 16, 17, 2018
Location: Bainbridge Island, WA
Cost: $575, before April 28; $650 after April 28
Cohousing books will be available for purchase at the event or by going to www.cohousingco.com/products.
Sign up by going to: http://www.cohousingco.com/events/seniorintensive2018.
Website: http://www.cohousingco.com/events/seniorintensive2018
Office Xpats Conference Center
403 Madison Ave N, Ste 240
Bainbridge Island, Washington 98110
United States


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The story continues with the second journal. This is an entry from her personal diary, by Elizabeth Lancaster Carsey 80-years-ago. Click here to read more.
No post today
Here's what else was happening 80-years-ago today
The Battle of Albarracín began.
Hormel Foods Corporation began selling the canned meat product Spam
Franklin Roosevelt addressing a gathering from the back of his car.
Pennsylvania Gov. George Earle is on the cover of this week's Time Magazine


text: NAVFAC Hawaii Commanding Officer Capt. Dean Tufts (right) presents a Navy and Marine Corps Achievement Medal (Gold Star in Lieu of Third Award) to BUC (SCW) Boy Julito L. Talaro during his retirement ceremony, Joint Base Pearl Harbor-Hickam, Hawaii, Nov. 24. The award is for "professional achievement while serving as Leading Chief Petty Officer for NAVFAC Hawaii and Joint Base Pearl Harbor-Hickam from September 2012 – November 2015." Talaro served the U.S. Navy for 20 years. His official transfer from active duty to the Fleet Reserve of the U.S. Navy will occur Dec. 31. (U.S. Navy photo by Denise Emsley, NAVFAC Hawaii Public Affairs/151124-N-OF713-053)


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King George unlikely
The Tizzard team are keen to get some more experience into their World Hurdle winner after he made a couple of notable errors at Cheltenham
THISTLECRACK is more likely to run in the Grade One novice chase at Kempton on Boxing Day rather than the 32Red King George VI Chase following his win at Cheltenham on Saturday.
Last season's champion staying hurdler made it two from two over fences in facile fashion, although he did make a couple of jumping errors.
Colin Tizzard's star performer is set to run at Newbury's Hennessy meeting before going to Kempton where the Kauto Star Novices' Chase is the preferable objective at this stage rather than the big race of the day.
"He's absolutely fine. He's 100%. He ate up when he got home and didn't have a particularly hard race," Joe Tizzard, the trainer's son and assistant, told at The Races.
"We saw the race as a positive. The overall performance was impressive as ever. We purposely took him to Cheltenham on his second run to get experience there over fences.
"I had a long chat with Tom Scudamore this morning. He was in second gear and was going too well.
"The first ditch he's had a little guess at it and come up a fraction early. The second one he got there. If he's going to stand off, he gets there.
"It's all part of the learning curve and I think in a truer-run race those issues wouldn't have happened and certainly once Tom let him bowl on and go that extra gear faster, he was a lot more accurate.
"We want to get plenty of experience into him so we're going to go to the novice chase at the Hennessy meeting and then he'll head to Kempton on Boxing Day.
"There are no definites on which race he'll go for yet, but at the moment I'd say dad and I are swaying towards the Feltham (Kauto Star Novices' Chase)."


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Intel Austria GmbH
Intel Austria GmbH is a subsidiary of Intel Corporation headquartered in Santa Clara, USA. The company develops and markets innovative semiconductor products and solutions for mobile communications – most notably in the rapid-growth market segments of smart phones, tablets and ultra-low-cost mobile phones.
Intel Austria GmbH has approximately 4,000 employees all over the world, about 38 of them work in Villach. The company is represented in altogether 17 countries around the world and has a strong presence in the Asian growth markets.
Our vision at Intel Austria GmbH is to pave the way towards this networked world by providing innovative, fine-tuned mobile communications solutions. Joining forces with the parent company Intel means that in future Intel Austria GmbH will be in a position to integrate mobile communications technology and application processors in intelligent solutions.
Role and Key Contribution
- Intel Austria GmbH possesses comprehensive know-how in the areas of RF, mixed signal/power management, monolithic integration and mobile phone software.
- From cost-efficient 2G/3G single-chip platforms for ultra-low-cost mobile phones and entry-level smart phones, through to leading-edge 3G and 4G slim modem and RF solutions for smart phones and tablets commanding higher prices.
Intel Austria GmbH
|Freistädter Strasse 400
|Europastraße 8
|4040 Linz, Austria
|9524 Villach, Austria


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Emporia (EHS) Class of 1982 Alumni List
Help us Update the Emporia 1982 Class List by adding any names missing from the list below:
Registered Alumni
1982 Class List
- Michael Beran
- Shaun Brown
- Rosemary Cortez
- Noelle Eggeman
- Gail Farr
- Tina Tina Galloway Hernandez
- Leann Hufferd
- Kim Jarvis
- Doug Johnson
- Kelly Kramer
- David Mcmurphey
- Shawn Smith
- Janet Underwood
- Kendra Ferrell Zych
Know Emporia Class of 1982 graduates that are NOT on this List? Help us Update the 1982 Class List by adding missing names.
1982 Emporia High School Yearbook
1982 Emporia High School Yearbook
Click here to view at Classmates.com®
The most popular movie of 1982 was ET: The Extra-Terrestrial which has grossed over $435,110,554 since its release. The TV series Dallas was the most popular show of 1982.
Hit Songs From 1982
I've Never Been To MeCharlene
Always On My MindWillie Nelson
Waiting On A FriendRolling Stones
Key LargoBertie Higgins
Eye In The SkyAlan Parsons Project
Who Can It Be Now?Men At Work
Turn Your Love AroundGeorge Benson
867-5309 (Jenny)Tommy Tutone
Hurts So GoodJohn Cougar
Only The LonelyMotels
Hit Movies From 1982
Hit TV Shows From 1982
Reunions and Emporia High School News
More 1982 alumni from Emporia HS have posted profiles on Classmates.com®. Click here to register for free at Classmates.com® and view other 1982 alumni.
If you are trying to find people that graduated in '82 at EHS in Emporia, KS, check the alumni list below that shows the class of 1982.
If you haven't already, we also encourage you to register for free on this site. You may also want to check out the latest news and school memories.


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Let the CrowdFunding begin! We Need Your Help!
Hello Pangeans,
It's time to begin the crowdfunding campaign! We'll be announcing our project on Kickstarter and we've just launched a campaign on IndieGogo.com, which you can learn more about here:
What's in it for you, you ask? Good question. For each site the rewards and criteria will be different, but donating on any site will give you the good feeling of literally having a hand in uniting the world! Here's what you can expect to receive as a thank you from our team on IndieGogo:
$1: A public shout out on our site "hail to… (your name) for supporting us!" on our public Community page
$15: Limited edition posters from OP shipped to you
$50: Limited edition t-shirt that lets others know you got on the bandwagon early.
$65: First access to private site prototype
$150: A full OurPangea package! Posters, a t-shirt, and shout out on the OurPangea home pages
$1000+: Be one of the founding groups. Donate $1000+ and we'll make you a custom group!
How else can you help?
Send the word out to all your friends! We appreciate support in all forms and are thankful for all the help you give!
Here are a few other places to check out and support our projects:
We're kicking off our Kickstarter campaign and all the other crowd funding projects so everyone can have a hand in building OurPangea together.


text: Have any of you found that the standard 6-48 screws in most commercial actions' scope mounting holes to be inadequate for holding the heavier scope/mount setups? I am considering upgrading on my Tomahawk before the scope is mounted. Here's the setup: M700 SS LA RDP custom 30MOA Base Night Force Rings Leupold 8.5-25x50 LR I know it can't hurt to upgrade, but is it worth the effort and expense???


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These Forums Have Moved
The Komodo forums have moved to a new home at community.komodoide.com, please head over there to post your topics!
Note that the new forums are a fresh start - you will have to register a new account.
Are there any applications which are incompatible with Komodo?
The following applications have been known to cause problems with Komodo:
Norton Firewall / AV
Macafee Firewall / AV
Checkpoint VPN
Black ICE Defender
Consult the Komodo release notes for further information on application conflicts.


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Shendel the Vengeful Spirit is a ranged agility support hero that has many uses in the game, one of which is to save team-mates from an impending death.
Vengeful Spirit's first ability is called Magic Missile. It is a generic single-target stun that at Level 4 will deal 325 damage and stun the target for 1.75 seconds. The range of the skill is 500, which interestingly enough is still higher than your attack range, which is a measly 400.
Wave of Terror is Vengeful Spirit's second ability. It is a very useful skill as it will apply debuff on enemies at 1400 range. This debuff will reduce their physical armour by 5 for 20 seconds, we well as deal 75 damage at its highest level. Vision is briefly given for the area the spell covers and interesting side note is that the damage done is considered HP-removal, which in essence means that it will not prevent Blink Dagger from being used.
Shendel's third ability is called Vengeance Aura. It is a passive skill that will grant allied units in a 900 Area of Effect (AoE) a bonus 36% damage. Before you get all excited, just remember that this boost if for base damage only and therefore items will not be taken into effect. Regardless of that, this skill shines late game when your carry is ready to take over.
Arguably the main reason why Vengeful Spirit is an amazing hero and quite often picked in team matches is because of her ultimate Nether Swap. At Level 3, you will be able to instantly swap position with any hero, ally or enemy, in a 1200 range. You can imagine the uses of this skill, be it isolating an enemy hero or saving an important team mate's skin. One really important thing to note here is the fact that not only does it interrupts channelling skills, but will also go through magic immunity.
On paper, Aghanim's Scepter may seem weak on Vengeful Spirit as it only lowers down the cool-down of her ultimate. In reality, however, having the cool-down lowered from 45 to 10 seconds is absolutely game-breaking due to the fact that you can use this multiple times in a team fight if you are able to stay alive.
It is quite common to see some players trying to go for a carry build with Vengeful Spirit. While there is no denying the pleasure derived out of getting kills and boasting a impressive stat chart, stripping Vengeful Spirit from her primary role and a role that she does extremely well is not advised. It is important to remember that support is just as important as going in and dishing out lots of damage. Do not be afraid to sacrifice yourself in order to isolate enemy carry hero and helping your team get rid of him to turn the odds heavily in your favour.


text: Full marks for Quickslide on recent audit Being the first business to receive a perfect score of 100% on a recent audit, West Yorkshire-based window and door manufacturer Quickslide is understandably very happy. The company, which manufactures and supplies high quality PVC-U and aluminium windows and doors, were audited by CENSolutions Ltd last month specifically for the systems process within its aluminium bi-fold door department. MD Michael Connor explained: "We're over the moon to have received 100% on the audit and be awarded CMS Quality Mark EN 14351, plus, being the first company to achieve this is something we are extremely proud of. This is a bi-annual audit so standards are always maintained, and this result further shows our commitment to producing a first class product. The audit looked at areas such as; Process Control, Contract Review, Training, Internal Quality Audits… basically it covered the entire process within our aluminium department." Paul Scrivener from CENSolutions carried out Quickslide's Bronze BS EN14351 audit: "The audit was as perfect as you could possibly get; I found no issues whatsoever with the fabrication of the bi-fold doors, and quality control in the factory was 100%, with every check possible being carried out. "As far as the mandatory clauses of BS EN14351 are concerned, Quickslide's Quality Manager Alex Cotos has ensured that all the supplier technical information is available and filed correctly and all frames were being labelled up with the correct Bronze CMS label. Quickslide manufactures a very high quality product and everything can be backed up with all the relevant technical information." Best known for its acclaimed sliding sash windows, Quickslide has been instrumental in bringing this former niche product into the mainstream of the retrofit and new-build markets. For more information call 0844 5610 623 or visit www.quickslide.co.uk. Quickslide: For further information, more news and contact details ...» News title: - Full marks for Quickslide on recent auditSubmitted by: - Quickslide Date published:- 20/04/2016 12:39:04


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Spiced Strawberry Crumble
Hello everyone!
Today's recipe is part of my "In Season Inspiration" series. For those who do not remember, this comes from a story that I love; a story that takes place in a farmers market and how the tentative steps between a baker and a farmer evolve into a beautiful love story. The first post of the series was devoted to rhubarb and I made a Rhubarb and Cream Cheese Danish. In May, though, it's time for strawberries.
I know, I know. Me doing yet another strawberry recipe is nothing new. But I promise that you will fall in love with how easy and simple this recipe is.
It's the flavor combination, though, what will convince you that this is a great dessert. You will taste the tartness of the strawberry, which will be immediately contrasted by the sweetness of the crumble. The slight note of ginger in the filling and the aromatic presence of the cinnamon in the topping will give it a spiced taste that, I promise, you will love.
You should wait for it to cool down completely to eat it. Or you can just dive in when it's not hot enough to burn your tongue. Either way, it's a lovely dessert. However, I recommend you to wait. Even better, put it in the fridge for a few hours and eat it completely cold! Now that summer is starting to show its colors here, this refreshing and sweet dessert it's perfect for it!
Spiced Strawberry Crumble
Ingredients filling
2 11x11cm molds
- 450g chopped strawberries
- 100g sugar
- 1 Tbs cornstarch
- ½ tsp ginger
For the crumble:
- 120g flour
- 90g brown sugar
- ½ tsp baking powder
- ½ tsp cinnamon
- ½ tsp salt
- 100g butter, softened
- Pre-heat the oven at 190ºC (375ºF).
- In a medium bowl, mix all the filling ingredients; strawberries, sugar, cornstarch and ginger. Pour the mixture between the two molds.
- In another bowl, mix flour, brown sugar, baking powder, cinnamon and salt and stir well. Add the softened butter in big cubes and mix with a fork or your fingers until achieving a crumble like texture.
- Sprinkle the crumble mixture over the two molds and bake for 40 minutes approximately, the crumble must be slightly golden.
- Let it cool down before eating.
So that's it! I told you it was easy, right? Here's the free printable for the recipe that you can download if you want:


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Legal Notice
The information displayed on this website by Kasteel Wittem has been put together with the greatest of care and attention at all times. Nevertheless, information published on this site may be incomplete and/or incorrect. The information on the website is regularly supplemented and/or updated.
Kasteel Wittem retains the right to implement any amendments with immediate effect and without making any prior announcement.
Certain (hyper)links on this site will take the visitor to websites away from the Kasteel Wittem domain, which are not the property of Kasteel Wittem, but which are only included for providing information to the visitor. If these links are activated you will leave our website. Although Kasteel Wittem is extremely selective with respect to the sites referred to , we cannot be held liable for their content and functioning, or for the quality of any products and services which they offer. Any liability for the content of websites not maintained by Kasteel Wittem is explicitly rejected.
Kasteel Wittem excludes any liability for direct and indirect damage, of whatever nature, which ensues from or relates to the website.


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Readings are not live or constant. They are taken from the last time your device finished its process. Check your Last Activity to tell when the battery and signal readings were taken. It is not uncommon to see batteries fluctuate slightly. If batteries fluctuate greatly it may indicate that one of the batteries has a dead cell. Cell signal will also fluctuate as it comes in waves.
Lithium batteries should always read 100%. The system measures the load they are pulling. If you see lithium batteries start to drain down it is time to change them, they are not pulling the full load.


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Full Moon in LibraMarch 29, 2010 5:25 pm PDT
During the Moon in Libra, relationships become our source of growth with our beloveds or in our relationship to beauty, to friendship, to our creative muse, to fairness and equality. While you need to avoid taking responsibility for everyone's happiness, you can be a real leader toward dynamic cooperation and peaceful co-existence. Excerpted from the We'Moon Datebook.
This month's one and only Full Moon artist is a splendiferous combination of many lovely Libran traits, she is not only a crystal healing, lightworking, soulful, artistic creator, but a Reiki practitioner, holistic healer, angel seer, and breast cancer survivor. I hope you enjoy her inspirational story.
Raleigh, North Carolina, USA
I am a Libra, born on September 25 many moons ago. Libras love beauty, harmony, and balance. Appropriately enough, my purpose in life is to create beauty, harmony, and light. I am doing this by being a Reiki practitioner and by creating jewelry for your body and soul.
My Reiki practice helps to balance and harmonize your body, your mind, your emotions, and your spirit. My intention for my jewelry is to bring more love, more light, more peace, more beauty, and more of your heart's desires into your life. I joyfully infuse all of my creations with love, healing energy ? including Reiki energy ? and prayers.
A very UN-scientific survey among my friends and fans shows that the words most used to describe my creations are: elegant, harmonious, graceful, beautiful… all typical Libran traits! I call my style "neo-classical." A Libra is too well-balanced to be avant-garde, though I do admire the talent and creativity of those at the artistic forefront.
I was born in South Vietnam and grew up there. After I got my French Baccalaureate degree, I moved to the United States to further my education. Upon getting my master's degree, I worked as a computer programmer, and then as a web site designer and producer. I have since left the corporate world about five years ago to devote myself to Reiki and jewelry design.
While I was a technical person, and my Libran artistic tendencies were dormant back then, I had noticed long ago that I made people feel better by my presence alone. I found out recently that this is said of many Librans: "They always make you feel better for having been with them."
My interest in holistic healing started about fifteen years ago, when a beloved cat got seriously sick and modern medicine could not help him. I studied herbs, homeopathy, and crystals. I "discovered" Reiki in 2001, and was attuned to the first level of Reiki in March 2002.
A week after that first attunement, a murder suicide took place in my neighborhood. I was totally freaked out by this event, and after a few sleepless nights I called my Reiki teacher, asking for help. She told me to visualize angels surrounding me and my house with the golden light of grace. At that time I was sitting next to a window, and I happened to look out at the golden light of the setting sun streaming in through the window.
Opalescence Necklace
THAT was the moment I first realized that angels really do exist, and that there was a whole world my physical eyes could not see. That experience was the beginning of my spiritual awakening, and marked the beginning of my personal healing journey.
Reiki also unleashed my Libran creativity and artistic talents, and I started making suncatchers and jewelry out of beads and healing stones. The act of making jewelry is for me a form of meditation and prayer. It helps me stay balanced and fulfills my Libran need for peace and harmony.
Essence of a Woman Earrings
I found this tidbit on a web site: "Librans are sensitive to the needs of others and have the gift, sometimes to an almost psychic extent, of understanding the emotional needs of their companions..." Well, in my Reiki practice, I offer intuitively designed and one-of-a-kind Reiki jewelry. If you choose a Reiki session, I will create after that session, under your guidance's direction, a one-of-a-kind necklace or bracelet using semi-precious stones, Swarovski crystals, sterling silver, glass beads and/or gold accents. I then charge this jewelry with love, healing energy, and prayers, to assist you in holding the energetic balance that you received during your Reiki session.
The designs I offer in my Etsy store are also charged with healing energy, love, and prayers, even when they do not contain semi-precious healing stones, since anything can be filled with good energy! While they are usually not designed with a person in mind, I know that they will find the right owners, and will bring to their owners more peace, more divine grace, more joy!
In 2007 I got another opportunity to evolve spiritually: breast cancer. This traumatic experience helped me to further open my heart, to become stronger as a person, to enjoy life more, and to be grateful. This has inspired me to create a line of inspirational necklaces, such as the ones featured in this post.
Be Here Now Necklace
To connect with more Full Moon Artists please click on the link.


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Roku recent dropped the price of its insanely popular Roku Streaming Stick to $39.99, pricing it exactly in line with Amazon's Fire TV Stick. That is a truly terrific price for such a great product, giving users access to thousands of streaming content sources accessible through Roku's awesome UI. But you might not know that you can get one for even less than that — $31.99 to be exact. Amazon has a great sale going right now on Roku Streaming Stick refurbs, and we highly recommend taking advantage.
Here are the highlights from the product page:
* This Certified Refurbished product is tested and certified to look and work like new. The refurbishing process includes functionality testing, basic cleaning, inspection, and repackaging. The product ships with all relevant accessories, a minimum 90-day warranty, and may arrive in a generic box. Only select sellers who maintain a high performance bar may offer Certified Refurbished products on Amazon.com
* Powerful quad-core processor and fast dual-band wireless. 8x more processing power than before
* Access to Amazon, VUDU, Netflix, Hulu, Google Play, and more
* Portable for different HDTVs in your home, hotel, and dorm rooms
* Unbiased search results across top channels to find where it's free or cheapest to watch
Follow @BGRDeals on Twitter to keep up with the latest and greatest deals from around the web. Quantities may be limited. Prices are subject to change without notice and coupons may expire at any time. BGR may receive a commission on orders placed through this article.


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Original Research ARTICLE
Regional Gray Matter Atrophy Coexistent with Occipital Periventricular White Matter Hyper Intensities
- 1Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, China
- 2Department of Neurology, Chengdu Military General Hospital, Chengdu, China
- 3Department of Radiology, Xinqiao Hospital, Third Military Medical University, Chongqing, China
White matter hyperintensities (WMHs) and brain atrophy often coexist in the elderly. Additionally, WMH is often observed as occipital periventricular hyperintensities (OPVHs) with low-grade periventricular (PV) white matter (WM) lesions and is usually confined within an anatomical structure. However, the effects of OPVHs on gray matter (GM) atrophy remain largely unknown. In this study, we investigated GM atrophy in OPVHs patients and explored the relationship between such atrophy and clinical risk factors. T1-weighted and T2-weighted Magnetic resonance imaging (MRI) were acquired, and voxel-based morphometry (VBM) analysis was applied. The clinical (demographic and cardiovascular) risk factors of the OPVHs patients and healthy controls were then compared. Lastly, scatter plots and correlation analysis were applied to explore the relationship between the MRI results and clinical risk factors in the OPVHs patients. OPVHs patients had significantly reduced GM in the right supramarginal gyrus, right angular gyrus, right middle temporal gyrus, right anterior cingulum and left insula compared to healthy controls. Additionally, OPVHs patients had GM atrophy in the left precentral gyrus and left insula cortex, and such atrophy is associated with a reduction in low-density lipoprotein cholesterol (LDL-C) and apolipoprotein-B (Apo-B).
White matter hyperintensities (WMHs) and brain atrophy often coexist in the elderly. Furthermore, WMHs can be divided into paraventricular WMHs (PVHs) and deep white matter hyperintensities (DWMHs; Katsumata et al., 2010). Previous studies have suggested that PVHs and DWMHs have different clinical and pathological features with PVHs related to brain atrophy and DWMHs related to cerebrovascular diseases (Barber et al., 2000). It should be noted that the degree of cognitive impairment associated with WMHs also depends on the volume and location of the lesions, as well as other factors such as brain reserve (Brickman et al., 2011; Murray et al., 2011; Smith et al., 2011; Hulst et al., 2013). Additionally, the impact of WMHs location is often assessed by dividing the brain into different regions, e.g., the occipital, temporal, frontal and parietal lobes, as well as the basal ganglia and infratentorial region. In particular, WMH is often observed as occipital periventricular hyperintensities (OPVHs) with low-grade periventricular (PV) WM lesions and is usually confined within an anatomical structure. However, the effects of OPVHs on gray matter (GM) atrophy remain largely unknown.
Magnetic resonance imaging (MRI) is a non-invasive medical imaging technique that can detect WMHs using T1-weighted and T2-weighted images. Voxel-based morphometry (VBM) analysis was recently developed to increase the sensitivity of MRI in the investigation of focal differences in brain anatomy using Statistical parametric mapping (SPM). In this study, we investigated GM atrophy in OPVHs patients using T1-weighted and T2-weighted MRI with VBM analysis. Additionally, the clinical (demographic and cardiovascular) risk factors of the OPVHs patients and healthy controls were compared. Lastly, we explored the relationship between the MRI results and clinical risk factors in OPVHs patients.
Materials and Methods
Patients with OPVHs (n = 97) and healthy controls (n = 73) underwent MRI scanning between 2012 July and 2015 July in the Department of Neurology in Xinqiao Hospital, Third Military Medical University. The subjects (age range: 55–85 years old) were restricted from vitamin 12 intake for 3 months prior to scanning. It should be noted that subjects with other diseases leading to white matter (WM) lesions, such as multiple sclerosis, toxic cerebral WM lesions, progressive multifocal leukoencephalopathy, atrial fibrillation and thyroid disease, were excluded from the study. Additionally, cerebrovascular disease induced by heart and aorta embolism, atrial fibrillation, valvulopathy, endocarditis, myocardiopathy, left atrioventricular valve stenosis or ventricular aneurysm, vasculitis, familial high homocysteine, infectious diseases, anemia or malignant disease, intracranial tumors, any systemic diseases, receiving special treatment such as radiotherapy, drug chemotherapy and biological therapy, as well as immune system diseases such as connective tissue or autoimmunity diseases, were also excluded from the study. It should be noted that OPVHs patients have OPVHs ≥1 according to the Fazekas scale. Additionally, the patients did not have lesions in other locations, and the healthy controls (CN) had no WMHs in any location of the brain. This study was approved by the medical ethics committee of Xinqiao Hospital, Third Military Medical University, Chongqing, China. Full written informed consent for participation was obtained from each subject.
The gender (Gen), age, hypertension (Htn) and diabetes mellitus (DM) history, current smoking (CS) and current alcohol use (CAU) were obtained from the patient-administered questionnaire. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), uric acid (UA), apolipoprotein-A1 (Apo-A1) and apolipoprotein-B (Apo-B) were also measured.
MRI Protocols
All MRI data were obtained using a 3.0 Tesla scanner (General Electric, Milwaukee, WI, USA) with a 12-channel head coil. Fast spin-echo (FSE) T2-weighted images and fluid attenuation inversion recovery (FLAIR) T1-weighted images were acquired with TE/TR = 112.2/3160 ms and TE/IT/TR = 27.072/860/1696.68 ms, respectively. All MRI images were acquired with a voxel size of 0.4688 × 0.4688 × 5 mm3, 20 sagittal slices and an in-plane resolution of 512 × 512. MRI images were then assessed visually by two neurologists using the Fazekas scale (Fazekas et al., 1987). Note that all subjects had no cerebral infarcts defined as focal hyperintensities in T2 images.
Data Analysis
All statistical analyses of Demographic and clinical variables were performed using SPSS20 (IBMSPSS, Chicago, IL, USA). Data are presented as the means (standard deviation). Chi-square test and Student's t-test were used to determine significant differences of the frequencies of categories and differences in continuous variables, respectively, between the groups.
The MRI data were processed using the SPM8 (Welcome Department of Imaging Neuroscience Group, London, UK1) with VBM implemented in the VBM8 toolbox2. Images were bias-corrected, tissue-classified and registered (Ashburner and Friston, 2005). Subsequently, VBM analyses were performed on the normalized GM and WM segments. Finally, the images were smoothed with a Gaussian kernel of 8 mm full width at half maximum (FWHM). Voxel-wise GM differences between OPVHs and the CN group were examined using the independent-sample t-test. To avoid possible edge effects between different tissue types, we excluded all voxels with GM values of less than 0.09 (absolute threshold masking). We also applied a threshold of p < 0.001 with 30-voxel clustering criteria and family-wise error rate (FEW) correction to eliminate potential type I errors. Age was used as a nuisance effect. Multiple regression VBM analysis was performed to explore the relationship between the MRI results and the clinical factors.
Clinical Factors of the OPVHs Patients and CN
Table 1 summarizes the clinical factors of the OPVHs patients and CN. Chi-square test and Student's t-test showed that TC, LDL-C and Apo-B were significantly lower in the OPVHs patients than the CN (p < 0.05). The OPVHs patients were significantly older than the CN. It should be noted that Gen, CS, DM, CAU and Htn showed no significant differences.
Comparison Between MRI Results of OPVHs Patients and CN
Figure 1 shows the comparison between two typical T2-weighted MRI images obtained from a OPVHs patient and a CN. WMHs were bright with higher signal intensities. Note that no subjects had cerebral infarcts defined as focal hyperintensities on T2 images. Figure 2 and Table 2 show the VBM results: OPVHs patients had significantly reduced GM in the right supramarginal gyrus, right angular gyrus, right middle temporal gyrus, right anterior cingulum and left insula compared to the CN (P < 0.001, uncorrected, with 30-voxel clustering criteria).
Figure 1. Two typical T2-weighted Magnetic resonance imaging (MRI) images obtained from a occipital periventricular hyperintensities (OPVHs) patient (A) and a healthy control (CN) (B). White matter hyperintensities (WMHs) were bright with higher signal intensities (A). Note that subjects had cerebral infarcts, defined as focal hyperintensities on T2 images.
Figure 2. Voxel-based morphometry (VBM) results of gray matter (GM) atrophy in OPVHs patients compared with CN. (A) Statistical parametric mapping (SPM) results in various brain regions. (B) GM atrophy was found in the right supramarginal gyrus, right angular gyrus, right middle temporal gyrus, right anterior cingulum and left insula compared to the CN (P < 0.001, uncorrected, with 30-voxel clustering criteria).
Multiple Regression VBM Analyses
For multivariate statistics, a p value of less than 0.05 in the univariate analysis was applied. Age and OPVHs as well as TC and LDL-C were strongly colinear in an orthogonal design; thus, only Fazekas score, LDL-C and Apo-B were applied for subsequent multivariate regression analyses. The reduced GM volumes of the left precentral gyrus and insula cortex were correlated with Fazekas score, LDL-C and Apo-B (p < 0.05, family-wise error (FSE)-corrected with 30-voxel clustering criteria; Table 3, Figures 3, 4).
Figure 3. Significant brain area of OPVHs in multivariate regression analyses. (A) SPM results in various brain regions. (B) 3D brain map. GM atrophy was found in the left precentral gyrus and left insula cortex of patients with OPVHs in a multivariate regression analysis (P < 0.05, FWE-corrected, with 30-voxel clustering criteria).
Figure 4. Scatter plots of the relationship between potential clinical risk factors and the reduced GM in OPVHs patients. (A) Scatter plots of the relationship between potential clinical risk factors and reduced GM in the left precentral gyrus. (B) Scatter plots of the relationship between potential clinical risk factors and reduced GM in left insula cortex. The reduced GM volume of the left precentral gyrus and insula cortex were correlated with Fazekas score, low-density lipoprotein cholesterol (LDL-C) and apolipoprotein-B (Apo-B).
OPVHs, a subgroup of WMHs, are frequently observed in elderly subjects (de Leeuw et al., 2001). Age and Htn have been reported to be the most common risk factors for WMHs (Liao et al., 1997; de Leeuw et al., 2002; Popa-Wagner et al., 2014, 2015; Pantoni et al., 2015), while hyperlipidemia, smoking, high body mass index, decreased vitamin B12 and alcohol may also be associated with WMHs (Breteler et al., 1994; Longstreth et al., 1996; Liao et al., 1997; Jeerakathil et al., 2004; Hickie et al., 2005; Murray et al., 2005; Stenset et al., 2006). Our study showed that Age, TC, LDL-C and Apo-B were statistically different between OPVHs group and CN group, OPVHs group had older age and lower TC, LDL-C and Apo-B compared with CN. Although the mechanism for the inverse correlation between TC, LDL-C and Apo-B and OPVHs is not fully understood, it should be noted that cholesterol may play an important role in neuron repair and remodeling in the central nervous system (Dietschy, 2009). Thus, the reduced cholesterol level may contribute to the reduction in WM.
Previous studies showed that WMHs have been associated with a number of adverse outcomes, including cognitive impairment, functional disability or even death (Scott et al., 2015; Yamawaki et al., 2015; Abraham et al., 2016). Additionally, the total volume and location of WMHs are important determinants of the clinical relevance (Swartz et al., 2003; Yoshita et al., 2006; Biesbroek et al., 2013). Visual and automated rating scales have been developed to assess the severity of WMHs (Fazekas et al., 1987; Scheltens et al., 1993; Gouw et al., 2006; Maillard et al., 2008; Maldjian et al., 2013). Two lesion subtypes have been proposed based on their proximity to the ventricles. These include PV lesions, which are contiguous with the ventricles, as well as DWMHs lesions, which are distinct and separate from the ventricles (Fazekas et al., 1993; Enzinger et al., 2006; Spilt et al., 2006; Rostrup et al., 2012). These lesion classifications have been supported by previous studies (Zhang et al., 2013). However, the cognitive impairment associated with WMHs may also depend on brain reserve (Brickman et al., 2011; Murray et al., 2011; Freret et al., 2015). WMHs and brain atrophy often coexist in the elderly (Aribisala et al., 2013). However, few studies have investigated GM atrophy in OPVHs patients. Our results demonstrate that GM atrophy occurred in the right supramarginal gyrus, right angular gyrus, right middle temporal gyrus, right anterior cingulum and left insula in OPVHs patients. These results are consistent with previous studies (Sepulcre et al., 2009; Raji et al., 2012).
Shared vascular risk factors may be an explanation for their concomitance. One explanation that has been proposed is that an impaired autoregulation due to the microangiopathy in combination with the luminal narrowing reduces the cerebral blood flow (Waldemar et al., 1994) and induce OPVHs. The hippocampus and amygdala are sensitive to hypoxia and ischemia (Pulsinelli et al., 1982; Cervós-Navarro and Diemer, 1991), which may lead to neuronal loss in these brain structures (Kril et al., 2002). However, disturbances of WM integrity could also be involved in the pathogenesis of brain atrophy. Our results showed that the left precentral gyrus and left insula cortex were correlated with Fazekas score, LDL-C and Apo-B. Notably, LDL-C and Apo-B are independently correlated with reduced voxels; however, their roles could not be determined. One possible mechanism is the loss of myelin, axons, and oligodendrocytes and other glial cells in the WM as a result of ischemic damage due to the underlying small-vessel disease (Pantoni and Garcia, 1997; von Bohlen und Halbach and Unsicker, 2002; Du et al., 2005). Another possibility is that WMHs influence GM with projecting tracts that modulate neurotransmitters (Bocti et al., 2005; Behl et al., 2007; Kim et al., 2012).
Our study was conducted using a cross-sectional design based in a hospital and had a relatively small sample size. A specifically designed, randomized, controlled prospective population-based study is warranted in the future. Future studies may also assess the role between OPVHs, LDL-C and Apo-B in GM atrophy in a potential mechanistic study.
OPVHs patients had significantly reduced GM in the right supramarginal gyrus, right angular gyrus, right middle temporal gyrus, right anterior cingulum and left insula compared to healthy controls. Additionally, OPVHs patients had GM atrophy in the left precentral gyrus and left insula cortex, and such atrophy is associated with a reduction in LDL-C and Apo-B. OPVHs may lead to cerebral atrophy related to cognitive impairment. Future studies exploring the structural foundations of human cognitive impairment may benefit from our study.
Author Contributions
The specific work of each author in this study was as follows: JZ: perception and design; final approval of the version to be published; DD: participation in the whole work; drafting of the article; data analysis; CL: demographic and cardiovascular risk factor data collection; LS: demographic and cardiovascular risk factor data collection; CC: MRI data acquisition and assessment; TS: MRI data acquisition and assessment.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
This study was supported by a grant from Chongqing Science and Technology project, People's Republic of China (cstc2012gg-yyjs10009).
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Keywords: magnetic resonance imaging, occipital periventricular hyperintensities, voxel-based morphometry analysis, gray matter atrophy, LDL-C
Citation: Duan D, Li C, Shen L, Cui C, Shu T and Zheng J (2016) Regional Gray Matter Atrophy Coexistent with Occipital Periventricular White Matter Hyper Intensities. Front. Aging Neurosci. 8:214. doi: 10.3389/fnagi.2016.00214
Received: 15 April 2016; Accepted: 24 August 2016;
Published: 07 September 2016.
Edited by:Aurel Popa-Wagner, University of Rostock, Germany
Reviewed by:Shenqiang Yan, The Second Affiliated Hospital of Zhejiang University, China
Raluca Sandu Vintilescu, University of Medicine and Pharmacy of Craiova, Romania
Copyright © 2016 Duan, Li, Shen, Cui, Shu and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jian Zheng, email@example.com


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The Centre and the Punjab government have decided to hand over the investigations into the case involving the arrest of three armed Kashmiri students, associated with Ansar Ghazwat-ul-Hind (AGH), to the NIA, Punjab DGP Suresh Arora said Saturday.
The students were arrested last month in a joint operation by the Punjab Police and Special Operations Group (SoG) of Jammu and Kashmir Police from the hostel of CT Institute of Engineering Management and Technology in Shahpur, on the outskirts of Jalandhar. Two weapons, including an Assault Rifle, were seized from them.
The decision to hand over the case was taken after discussions between the state government and Union Ministry of Home Affairs. Initial investigations had revealed that the students, identified as Zahid Gulzar, Mohammad Idriss Shah and Yusuf Rafiq Bhatt, were linked with AGH, a Kashmir-based terrorist outfit with reported links to JeM.


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Chavez Supporters Surround TV Stations
Associated Press Writer
CARACAS, Venezuela (AP) _ Hundreds of supporters of President Hugo Chavez ransacked one TV station and surrounded others across Venezuela, accusing them of backing a general strike to force his ouster.
"Shut it down!" chanted protesters in front of Globovision television in Caracas on Monday. Waving Venezuelan flags, demonstrators spray-painted the station's walls.
Globovision broadcast images of its ransacked headquarters in the western state of Zulia, claiming Chavez supporters forced their way in, destroying windows, equipment and furniture.
Demonstrators also surrounded Radio Caracas Television, Venevision, Televen and CMT in Caracas, as well as a regional television stations in the cities of Maracay, Merida, Maracaibo and Barquisimeto. They also protested against a newspaper in Maracay.
"The people are in the streets defending their values and principles," said Interior Minister Diosdado Cabello, in a televised address during the protests. "The government doesn't want violence."
But OAS Secretary General Cesar Gaviria condemned the pro-Chavez protests against the media, saying they "threatened freedom of expression." The Organization of American States is mediating talks between the government and opposition.
Globovision television and other private news media said Tuesday they would protest the intimidation to the OAS' Inter-American Human Rights Commission. The commission has urged Chavez to guarantee the security of Venezuelan media in the past.
Chavez accuses the press of backing a general strike seeking his ouster. The overnight protests came after government television and radio summoned Chavez supporters to "defend democracy" in the streets.
The strike, in its ninth day, has crippled the oil industry _ the world's fifth-largest and the source of 70 percent of Venezuela's export earnings. The shutdown increased pressure on Chavez to give in to opposition demands to call a referendum on his government or resign.
Critics charge that the leftist Chavez has hurt the economy, polarized the South American nation along class lines and is unfit to govern. Chavez accuses the opposition of trying to spark a coup against his elected government.
During negotiations Monday, the government agreed to discuss a timetable for presidential elections, Gaviria said. There was no immediate comment from the government on that, and it was unclear if Chavez was considering an early vote.
A former army paratrooper elected in 1998 and re-elected in 2000, Chavez has insisted Venezuela's constitution doesn't allow a referendum until midway through a presidential term _ in his case, August 2003.
The opposition had demanded that he call a nonbinding referendum on his rule. Strike leaders raised their demands after three people were killed and 28 wounded at an opposition rally Friday, saying that Chavez must either call a binding referendum or resign.
On Sunday, Chavez accused Venezuela's media of waging a "terrorist and bloody" war against his government. Last week, some newspapers didn't publish for two days out of solidarity with the strike.
Journalists accuse Chavez of inciting violence against reporters. In Maracay, armed Chavez activists assaulted at least seven journalists covering the strike, El Siglo newspaper reported.
"This is worrying. We are at the mercy of the Chavistas," said Ever Garcia, the director of El Aragueno newspaper, which was surrounded by Chavez partisans in Maracay on Monday.
Meanwhile, the strike was gaining strength.
Production at Venezuela's two largest refineries, Paraguana and El Palito in western Venezuela, was paralyzed, Ali Rodriguez, the president of state oil monopoly Petroleos de Venezuela, confirmed. The Jose refinery in eastern Venezuela could shut down in 48 hours, said Luis Torres, the refinery's director of maintenance.
"We are threatened with a national disaster," Rodriguez said.
Rodriguez urged strikers to end their "sabotage," warning that gasoline shortages and electricity blackouts were imminent. He said the government, which temporarily seized truck fleets for distribution, was guaranteeing gasoline supplies for now.
Venezuelans waited for hours for gasoline and stocked up on food and water as the strike created shortages at markets, banks, pharmacies and service stations.
Strike leader Carlos Ortega said the strike will continue until Chavez leaves office.
"The people you never listened to are going to oust you," Ortega said.
Dozens of domestic flights were canceled. Several pilots of the Venezuelan airline Aeropostal Alas de Venezuela walked off the job Monday, said pilot Pedro Camero.
American Airlines canceled its night flights to Caracas because of the turmoil. Only three of the airline's 10 daily flights arrived in Caracas on Monday.
Venezuela's crisis caused January heating oil to rise 1.09 cents to 75.82 cents per gallon on the New York Mercantile Exchange. January crude increased 27 cents to $27.20 a barrel.
Polls suggest Chavez has the support of up to 45 percent of Venezuela's poor, but his overall popularity is about 30 percent.


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As announced at the VBA Mid-Year Meeting in March 2018, the Vermont Commission on the Well-Being of the Legal Profession (CWBLP) was formed in response to the 2017 report of the National Task Force on Lawyer Well-Being. The Vermont CWBLP began its work last year in response to a Charge and Designation from the Vermont Supreme Court. The Charge and Designation appointed Commissioners to work with seven stakeholder committees, including judges, the VBA, regulators, VLS, the current Lawyers Assistance Program, legal employers and lawyer professional liability carriers.
The CWBLP was tasked with creating a state-wide action plan with specific proposals, including (a) development of a policy for confidential intervention for lawyers, judges and law students struggling with mental health, well-being and/or substance abuse challenges; (b) development of a plan to support and sustain a Lawyers Assistance Program in Vermont and (c) development and provision of ongoing educational opportunities and resources regarding mental health, well-being and/or substance abuse.
The CWBLP submitted its State Action Plan to the Vermont Supreme Court on December 31, 2018. Click HERE for a copy of the Plan, HERE for the VBA website page with more details about the Commission, the stakeholder committees and their work, and HERE for a recent Bar Journal article about the CWBLP. Chief Justice Reiber, as Chair of the Commission, will address the membership about the Court's response to the Plan at the VBA Mid-Year Meeting at the Lake Morey Resort on March 21-22, 2019.
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PO Box 100, Montpelier, VT 05601-0100
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