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THE doyen of American pianists Richard Goode played a fascinating programme of Schumann and Chopin in Perth Concert Hall on Friday.
To describe Goode as American and a pianist is perhaps true, but his playing showed him to be much more – a complete musician: in him the aspects of thought and technical technique were thoroughly united.
His first half was devoted to two major works by Robert Schumann. He began with Kinderszenen (Scenes from Childhood) Op.15. In his hands these showed themselves to be miniatures only in length, the 13 pieces taking not many more minutes to perform. He opened up Schumann's world right from the start of Of Strange Lands and People lyrically at home with the voicing of individual lines, their rhythms and combinations, above all the sense of fantasy. He showed nimbleness in Catch and encouraged a warm tone from the superb Perth Concert Hall piano in Happy Enough. He had a nice ceremonial touch for Important Event leading into a deeply felt Träumerei (Dreaming) where the melodies seemed unbound to the barlines. Here his vocalizations became noticeable, as with his later stamping, my only negative criticism. He was nicely playful in Knight of the Rocking Horse, with the deepest emotion kept for the envoi The Poet Speaks.
Kreisleriana Op.16 which followed had all of these virtues plus a touch of insanity, suitable for Hoffmann's character Johannes Kreisler, the subject of these eight character pieces. It did have a mad start, but with a wonderful lyrical riposte the supporting harmonies well brought out. The third piece contrasted the rhythmic outer sections with a rolling legato where Schumann's lines were beautifully integrated. The abrupt return emphasized darkness. The sixth piece began with chivalrous Romanticism, the seventh with almost psychotic rushing. All was vividly portrayed in this too rarely played work.
One of Charles Ives' odder comments was that "we always tend to think of Chopin in a skirt." Not as played by Richard Goode! In no way denying his insight and supreme sensitivity there was vigour and dramatic power. The Nocturne Op.55 No.2 was forthright and lyrical, but with too much light for a night piece, notwithstanding the sensitive fioriture at the end. The Scherzo No.3 had an ominous introduction to the dramatic main section. The big tune was exactly that, really impressive. There were intentionally disquieting passages and a hurtling coda leading to a tragic finish. The Ballade No.3 had equally strong playing, its central section playful yet with underlying grandeur, calling magnificent sounds from the instrument. Between these two were three waltzes all flighted with a nice lilt and sprung rhythms.
Recalled repeatedly to the platform he delighted his entranced audience with a Mazurka, Op.24 No.2, which glinted and flashed and, returning to Schumann, a piece from his Davidsbündlertänze of fine lyricism.
Ian Stuart-Hunter


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Use the Tab and Up, Down arrow keys to select menu items.
This course looks at how language works in society. For example, it investigates linguistic variation and language use in conversations, the linguistic markers of social identity and attitudes to different varieties of language (accents, dialects etc).
When we hear somebody talk, even for the very first time, we make a split second judgement about them. That's because a speaker's language tells us something about them. We not only receive a linguistic message – the content of what is being said – but we also receive social information. Is the speaker male or female? How old are they? Are they working class or middle class? Are they happy or sad? In this course, we explore how our language is able to convey social cues such as these. Our overarching question is: how does our language influence who we are and who we are seen to be? To answer this question, the course is organised around five themes, taking us from the 'beginnings' to the 'end' of language. The blocks are:1. The 'beginnings' of languageKey questions: How did language develop in the human species? Do animals use language? How do children acquire their first language?2. What does our language say about us?Key questions: How does our language signal the social groups we belong to (e.g. our gender, our age, our social class)? How is language used to project aspects of our social identities?3. Society affects language use, and language use affects societyKey questions: How do our attitudes affect our language use? Why are certain types of language believed to be 'correct' while others are said to be incorrect and ungrammatical? Where do these beliefs come from and how do they affect our society?4. Managing our meaning in a social worldKey questions: How do we get our meanings across in conversation? Do we always say what we mean, and how do listeners understand implied meaning? How do we use language to maintain our social relationships? And how do we use language to cause offence?5. The 'ends' of languageKey questions: Can speakers' language ability 'disappear'? What factors lead to language problems in an individual? Can languages 'die' across whole societies? Can the spread of English be held responsible for the 'death' of other languages across the world?
By the end of the course, students will (1) have developed their knowledge of how language (including sound patterns and grammatical systems) can vary, (2) understand the relationship between language and society, and how e.g. social attitudes can affect language use, (3) understand how different groups of people use language differently. They will also (4) be able to conduct bibliographic searches of relevant work relating to language and society, and (5) be able to critically evaluate rival hypothesis. In particular, they will be able to think critically about the opinions very commonly expressed in the media about linguistic issues, and will be able to evaluate the evidence for those opinions.
Kevin Watson
Meyerhoff, M;
Introducing Sociolingistics;
Routledge, 2011.
Trousdale, G;
An introduction to English sociolinguistics;
Edinburgh University Press, 2010.
Trudgill, P;
Sociolinguistics: an introduction to language and society;
Penguin, 2000.
Library portalThe course outline is available on LEARN (only for students enrolled in this course).
Domestic fee $619.00
International fee $2,688.00
* Fees include New Zealand GST and do not include any programme level discount or additional course related expenses.
For further information see
School of Languages and Cultures.

subset: commoncrawl


text: Man found unresponsive in Windsor Park Loop News Created : 13 April 2018 Cayman News Police have confirmed that a man was found unresponsive by officers in the Windsor Park area on Friday afternoon. While very few details about the matter have been made public, Loop News understands that the deceased is originally from Jamaica. The deceased is said to have been an employee at Quick Images in George Town. He was also described as a regular attendee at the Church of God of Prophecy on Eastern Avenue . Residents in the area have told Loop News that they were interviewed by police officers, which has led to widespread speculation. However, one woman who claimed to be a friend of the deceased, who she named as 'Eugiene' noted that he did have an illness. Police have said that they would be issuing a more detailed report on Saturday. Get the latest local and international news straight to your mobile phone for free:


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James Tait // Consultant
Direct Line (03) 5560 2132
Email email@example.com
James (Jamie) Tait is a former partner in the firm with over 40 years experience covering many areas of the law. As a result he now is called upon both within the firm and by clients for general counselling. He practises mainly in Estates, Family and Business Succession Planning, the establishment and management of Charitable Trusts, Local Government, Planning and Development, and general Commercial matters particularly in relation to Duties and Taxes.
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Jamie is a director of the Gwen & Edna Jones Foundation, the Ray & Joyce Uebergang Foundation, and the Ern Hartley Foundation. He has served on many community committees including 17 years as a member of the Deakin University Council (for which the University honoured him with the award of a Degree of Doctor of the University), and 17 years on the Warrnambool Foreshore Committee. He has served on many Warrnambool City Council internal committees, and currently is a member of the City Development Advisory Committee, and the Warrnambool Entertainment Centre Re-development Project Community Consultation Panel. He is a Committee member of the Warrnambool Symphony Orchestra, and a life member of the Warrnambool Theatre Company and the Warrnambool Club.


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The free app offers delivery from some 70 local restaurants to Milwaukee, Tosa, West Allis, Shorewood and other areas.
Transportation technology giant Uber launches the restaurant delivery service UberEats today (Thursday, Feb. 16) in Milwaukee. The service offers access to full menus from more than 70 Milwaukee-area restaurants, according to a press release.
The application, available at UberEats.com, is a free download for iOS (Apple's operating system) and Android. After logging into the app, users choose the restaurant and menu item and pay with a registered credit card. Users also pay a flat $4.99 booking fee, along with the cost of the menu item and any applicable sales taxes.
Delivery is available in Milwaukee, Greenfield, Wauwatosa, West Allis and Shorewood. The list of restaurants (expected to expand) includes AJ Bombers, Bollywood Grill, Bumstead Provisions, Casablanca, Dandan, FreshFin Poke, Harry's Bar & Grill, Kanpai, Merriment Social, Saketumi, Pastiche and Smoke Shack.


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ECOCERT CANADA is known for their superior standards in terms of quality for their certifications. They demands impeccable traceability and guarantee the respect of our planet.
Lemongrass has a calming and mild smell, making it a great air freshener and natural deodorizer. When diffused it is known to boost energy, relieve headaches, anxiety, stress and irritability.
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Lemongrass (Cymbopogon citratus)
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Lemongrass is great to diffuse for it's calming and mild smell. It is known to relieve anxiety, irritability and insomnia, it is also a safe air freshener and natural deodorizer.
Dilute lemongrass oil in a carrier oil and massage on skin. Lemongrass oil is effective for all skin types, it has antiseptic and astringent properties making lemongrass perfect to achieve an even, glowing skin tone plus, it strengthens your skin tissues.
DO NOT use if pregnant or breastfeeding.
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*These statements have not been evaluated by the Food & Drug Administration, Canadian Food Inspection Agency or Health Canada. This product is not intended to diagnose, treat, cure or prevent any illness or disease.


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Small LED Under Cabinet Lights Package - Brown
This under cabinet LED light kit includes everything you need to brighten your kitchen. The 7 inch lights provided in this kit fit nearly every cabinet design. The wireless wall switch makes installation fast and easy. These lights provide a soft natural glow. The reflection on any surface is a solid light - not the spotty reflection of the individual LEDs on most LED under cabinet lights. This dimmable low profile light is designed to eliminate the individual LED reflection on the counter top. It comes in two white temperature color options 2700K or 3000K. The lights can be connected together in series for easy installation.
Maximum current wired in series: 1.8 A
Fuse Style: Auto Reset
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Lens: Polycarbonate
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Screws: Zinc-plated steel
4 x 7 Inch White LED Under Cabinet Light
1 x K Series - Classic White 2A Mini LED Controller
1 x K Series - Classic White Wireless Wall Switch
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10 x Wood Screws
4 x Drywall Anchors
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2 x Double Sided Tape (Small)
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1 x Barrel Jack 24V Power Supply - 2A
When choosing the type of atmosphere you want to project, lighting is one of the most critical decisions you can make...
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Under Cabinet Lighting is essential when accenting the back splash and counter top...
Haven Home Lighting under cabinet lighting systems make installing your lights fast and easy...


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News & Updates
Welcome to our collection of archived newsletters! Here you will find editions of East Brook News that are mailed electronically to our clients. If you are a client and would like to receive these newsletters on a routine basis, please contact us with your email address. We hope you enjoy the stories, veterinary information, photos and pet trivia included in each edition.


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Sep 23 2015
Team training tonight and the focus was on drugs used in mountain rescue
This evening saw an indoor training session take place at our Ladybridge Hall Base / HQ, which commenced at 20.00hrs.
A very intense and comprehensive session, gave a full overview on the Mountain Rescue England and Wales Drug Formulary, which has been issued by MREW for the period June 2014 to May 2017.
Introduced in 1991, this is the sixth revision of the MREW Formulary (Drug List)
An overview of all aspects of this formulary was covered, including Group 1 (Individual), Group 2 (Team) and Group 3 (Optional. Suitably Qualified Practitioners) drugs, their details and characteristics.
This overview was provided by very experienced team member Mark Scott, our current Equipment Officer – Medical, who is MREW Opiate trained.
Twenty nine team operational members took part in this evenings essential session, which is part of our 'build up' to the whole team membership taking part in the Mountain Rescue Casualty Care Certificate Course, early next year, which every team member is encouraged to take, and has to be renewed every three years.


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Stefan Doering (New York Entrepreneur Week) started an important Linked-In discussion, asking "As CEO, Where Do You Spend Most of Your Time?" Many leaders of businesses large or small, I suspect, would react much as Doering's audience ….
"On Monday I had a room of 30+ entrepreneurs glaring at me…. It started when I asked them how much time they spend in the following three basic areas of (any) business … The room fell silent when I told them how much they should spend:
Marketing: 60-80%
Production: 10-30%
Administration: 10%
…. [ because ] There is no one in your company that can sell your company better than you. No one!"
Doering's is timely advice to anyone with an interest in making their business more successful, but it is especially pertinent to the majority of entrepreneurs whose business is the creation of their subject matter expertise – their superior ability to make or do something useful.
Marketing isn't intuitive to many of us, and not comfortable for many others. If you're one of these ….
First – Take time to something about marketing. The web is full of useful sources, great discussions, and access to real expertise. Linked-In and similar networking sites are particularly useful.
Second – Invest a lot of time getting to know your customers. Spend more time listening than talking. Find out what makes their business and their customer tick. Spend less effort trying to explain why your offering is so good and more effort figuring out how to solve their problems.
Third – Structure every aspect of your company – from product design, to sales, to invoicing, to customer service, to how the phones are answered and the emails responded to – to make it easier and more attractive for your customers to deal with you.
Remember – The ONLY source of your profits is a throng of customers eager to spend their $$$ with you.
Tags: CEO activities, entrepreneur


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Mr. Milky, given she's Vorador's mystery woman and he's, by the time of SR1, centuries past, I'd say highly unlikely.
Er, to Corlagon: *insert catalogued reply here*
Mr. Milky, given she's Vorador's mystery woman and he's, by the time of SR1, centuries past, I'd say highly unlikely.
Er, to Corlagon: *insert catalogued reply here*
The 8th figure represents you, the player of the game. That's why it's so androgynous.
@The Hylden : I hear you, but chronological factors are of no issue here. It's a stone figure. Just a speculation about the pre-released mystery character from the menu screed and given the fact that Voradors mystery woman is quite a resemblance given the facial contour, I used it.
Also, why would he / she be holding the head of a vampire (presumably Zephon)?
I'd like to see your speculation, for a change, instead of constructive criticism.
Also, I don't want that anyone get the idea of a debate here, my goal is to make this thread a bit more challenging for some imaginative mind
You were just offered a chance to have a statue of yourself standing alongside vampire lieutenants and you rejected it. Just think about that the next time nobody builds a statue of you.
It's the priestess.
Sorry for the bump, but...
Anyone notice the wings on the upper right figure? Definitely Raziel.
Custer - the face alone is a dead giveaway that its raz.
"are you trying to bore me into submission?" ~ Raziel/Defiance
Sure, but in the actual game the figure's face & hair are different. While the wings are still there.
I can't believe I didn't notice those wings....
They still exist in the final version. That and his blue eyes always made me think of him as Raziel, but I somehow couldn't treat the remaining characters as other vampires because the extra figure was ruining the whole concept.
And looking at this early images I have to agree that it probably is the Priestess.
Damn! I just noticed that.also the flag on his hands
Looking at the face on the left side and in the middle of the screen (in terms of up and down)
This one is more effeminate than the others while in human form, and when red-eyed "she" still doesn't display fangs. Priestess
Then there's the bottom left statue who's wearing some ridiculous school uniform from the 1700s. That one might be a cross-dresser, or one of those adults with a diaper fetish....... Melchiah?
What´s more interesting that the figure on the middle left has white eyes in SR Beta, so maybe it is the Priestess..
I am totally performing thread necromancy, because heck, it's not often one can see a thread that was started due to a question I asked, getting an answer a good 9-10 years later.
Completely forgot my password for the account that I used to make my first (and only) post in this thread though, and the e-mail I used then is defunct too, which is a shame.
So, the conclusion is that it does seem solid that the original pre-release menu had one of the deleted bosses, IE, the priestess, included. This meant there was 8 figures on the menu, and when they switched to the updated version with all vampires, they didn't change this even though it meant there was an unexplained additional figure.
Case closed, as far as I'm concerned.
(Though arguments about which figure represents which brother are clearly never going to be entirely settled. I personally stand by Zephon being the one in fancy clothing, due to the parallel to him 'clothing' himself in the silenced cathedral. Plus, the youngest, Melchiah being ashamed of himself in the bottom right is perfect to me too. )
Sure they are
"A return to Nosgoth is not necessarily always welcome: only the attainment of that final gnosis will satisfy us." – Sam Zucchi


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I am using the classicthesis LyX template (http://code.google.com/p/classicthesis/), and was wondering how to change the format of the references in the bibliography? At the moment, the bibliography uses the plainnat style.
I want to use "et al." when there are more than 3 authors in a reference.
For example, at the moment, a reference may look like:
[7] H R Dinse, K Krüger, A C Akhavan, F Spengler, G Schöner, and C E Schreiner....
I want this to look like:
[7] H R Dinse, K Krüger, A C Akhavan, et al. ...
Please can you help me make this change?
Many thanks.


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This is an digitalised version of a piece made in oilpastel called Pommes dans la tete d'une femme lisant (Apples in the head of a woman reading) and is based on Picassos famous piece Tete d'une femme lisant and on a famous logo. This is one of the original pieces in my The iProject collection.
This product item discountinued, for more info please contact us, we can print design on simillar product for your


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October 2018
October is finally here! With the long hot summer firmly behind us and the busiest time for card making just round the corner, take a break from the rush to create a card for those who are celebrating during autumn. Featured on page 6 is adorable squirrel card, featuring delicately traced colours and mounted on a separate border, it's perfect for any occasion and the colour scheme of the card means that this design is also suitable for a man. ... Read More >>
On Sale: 07 Sep 2018
Based around pencil colouring, a project by Judith Maslen demonstrates how effective pencils can be. Entitled The Spirit of Autumn (page 16), the completed card comes complete with a step by step guide showing how you should be applying the colour and what shades of colour you should be achieving.
This month also sees the start of our Christmas collection for 2018, and I'm pleased to present to you a projects to get you started, Door to Door by Lesley Shore on page 24, and if it's whet your appetite for more, make sure you pick up next month's issue where you'll find a magazine chock-a-block with seasonal cards and designs.
Enjoy! Carl Golder, Editor


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About Us
Mirela is a highly trained and certified holistic therapist with over 20 years of international practice. She has practised in Mayfair, Harley Street and Bloomsbury and is now based in Islington, Canonbury.
Her passion for the health and beauty industry is evident in her constant pursuit for excellence and maintenance of the highest professional standards. Mirela's expertise has been featured on the BBC, in The Sunday Times, The Today's Therapist and Women's Fitness to name a few.
Mirela Health & Beauty was established in 1996. We have been based in the heart of leafy Canonbury in fashionable Islington for the past ten years and we are spread across two floors in an elegant listed period property in the Conservation area of Canonbury, Islington.
The concept behind Mirela Health & Beauty is to offer you a personal experience set in a boutique space. We want you to feel at home and offer you treatments that provide the utmost in relaxation, rejuvenation and wellbeing with a personal touch.
We pride ourselves on our highly qualified, dedicated and friendly international therapists who are either CIDESCO, CIBTAC, ITEC (or equivalent) trained and the CMA accredited. We are committed to exceeding your expectations every time you visit us!
Charities and Fundraisers
We have always been committed to playing a part in our community life by supporting local and national charities and organising fundraising events.
Throughout the year we regularly donate gift vouchers for our hair and beauty services as well as our products from both salons for raffles and auctions and also raise funds for various worthy causes.
Some of our favourite charities are:
Friends of the Rose Bowl, registered charity number 1079165 www.friendsoftherosebowl.org.uk
Kings Corner Project, registered Charity No. 288182 www.kcpyouth.net
NSPCC Islington Branch, registered charity number 216401 www.NSPCC.org.uk
Friends of Dallington, registered charity number 29770
The National Gardens Scheme, registered charity number 279284 www.ngs.org.uk
The Royal Gardeners Orphan Fund, registered charity number 248746 www.rfgc.org.uk
Canonbury Primary School, www.canonburyprimaryschool.co.uk
Children in Need, registered charity number 802052 www.bbc.co.uk/pudsey


text:
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text:
It's a strange weekend.
On June 23rd, 2016, I went to the voting booth before work and put my two cents in the EU referendum debate, which had been dominating headlines for weeks and months.
That evening, I watched as voting closed and volunteers across the country worked tirelessly to make sure everyone's vote was accounted for.
By the time I went to bed, the first counting result was yet to be announced. But there was an oddly justified sense of confidence that I would wake up to the same Britain.
On June 24th, 2016, I woke up to a worryingly divided nation instead, that was further handicapped by a lack of strong leadership.
As an immigrant living in the UK, a Vote to Leave is highly unsettling. How will this affect the economy and employment prospect? Is UK truly multicultural or am I not welcomed here?
A few hours later, I was on the phone with my parents.
"Maybe you shouldn't renew your Hong Kong SAR passport," they advised.
"Why?" I asked.
"You know, because of the missing booksellers," they replied in a sombre tone.
Five members of staff of Causeway Bay Books had been 'missing' from Hong Kong since late 2015.
Though most of them have now returned safely, one remains in custody of Mainland Chinese authorities.
Lam Wing-kee is so far the only one who has spoken out, confirming what many of us fear and believe: they were kidnapped and illegally detained by Mainland China. Thus, sparking more protests and calls for independence.
Two of these men hold dual nationalities – one British and the other Swedish. Yet, the respective consulates are almost powerless in reaching out to the Chinese authorities.
According to Chinese foreign ministry spokeswoman, 'any Hong Kong resident who is of Chinese descent and … born in the Chinese territories' are citizens of China.
The implication here is that the incident is 'purely China's internal affairs [in which] any foreign country has no right to interfere'.
In other words, holding my hometown passport nowadays could make me more vulnerable to China's twisted legal system. It has come to a point now where having none is better than having one.
But with Brexit upon us, what will it mean to be a British passport holder?
The next day, I watched Independence Day: Resurgence in the cinema.
The main battle is obviously between the human race and the aliens. But it essentially represents a joint effort between the military, scientists and a friendly space bot taking on the hostile alien led by their queen.
The word 'independence' has been ringing in my head for the past few days. What does it mean? What do we want independence from, and how do we achieve that? What do we gain and lose in the process?
Doing something bold on your own could be scary. Doing it with the right people and with an effective leader – we can embrace and support one another on this bumpy ride.


text:
Could yoga breathing be the answer you are looking for?
This world can feel like a crazy place sometimes. Many people respond to today's challenges by feeling anxious or withdrawing. Others find themselves allergic, in pain or concerned about other health issues.
How To Use Yoga To Handle Stress
When the going gets tough or the little things become irritating beyond tolerance, do you tend to fly off the handle easily or bottle up your emotions?
Imagine your life with less pain, reduced anxiety or with lower blood pressure. Imagine staying calm in the midst of crisis.
The breath is intimately connected to many of our physiological processes and to our emotions. For example if you get angry or upset your breath will be irregular, rapid and shallow. If you feel pain you may find yourself holding your breath or breathing very shallowly. If you continue these breathing patterns you will continue to be angry or your pain may worsen.
The breath is also connected to our spiritual states of being. When we are feeling unconnected and out of tune, the breath may be heavy and frequent. When we are feeling our bliss the breath feels lighter. In the ultimate states of reverie, samadhi or enlightenment, the breath slows down and may even stop. Becoming breathless is not the same as holding the breath. In fact it is quite the opposite.
Both the positive and the negative reactive breathing patterns happen automatically.
The good news is that you can choose to control and change your breathing. When you do this you can calm down or feel less pain. The concept is simple but it's not always easy to do. Especially in the heat of the moment or the intensity or persistence of pain.
Having a regular practice of yoga breathing can help you to change your breathing patterns when you need it the most.
If you wait until you are emotionally out of control or feeling the onset of a headache, it's really difficult to try to practice a breathing technique that you don't know well. That's why it's important to practice breathing exercises on a daily basis.
The amazing side effect of practicing regularly is that you just may find that you don't fly off the handle so easily, that your health is improving or you become the one who stays calm when everyone else is running in circles.
Change your breathing, change your life
Yoga Breathing helps us physically
- Reverse the stress response
- Lower heart rate
- Reduce pain
- Sleep better
Yoga Breathing helps us mentally & emotionally
- Reduce anxiety
- Reduce stress
- Reduce depression
- Feel happy
Yoga Breathing helps us spiritually
- Brings us to a state of calm
- Helps us to focus
- Helps us to feel connected
- Aides in feeling bliss
Think about it. If yoga breathing can positively affect this many areas of your life, consider how profound it is. On the flip side, incorrect breathing can be harmful.
Become aware of your breathing habits to change them.
If you want to change negative breathing habits, start by watching your breath. Is it:
- shallow
- short
- choppy
- irregular
- or do you hold your breath?
Often we are unaware of our breathing habits. You may find that the act of observing your breath will help you begin to change your breathing patterns. For example, you may not realize that you hold your breath when you are tense. As soon as you notice that you are holding your breath you are going to start breathing.
How to Practice Yoga Breathing
There are three phases of yoga breathing. In all phases breathe through your nose. Keep your shoulders and neck relaxed.
First phase is belly breathing. This is the foundational yoga breathing practice. It is used when no other breathing or pranayama is specified.
- Begin with your hands on your belly. As you inhale feel your belly move under your hands as it expands.
- As you exhale, feel your belly contract under your hands.
- Allow your breath to be as deep and slow as possible.
- Once you feel that you have the first phase often called belly breathing down, you can take your hands off and continue breathing without them on your belly.
Second phase. This phase is usually not practiced by itself, other than to learn it as a stepping stone to the full yogic breath.
- Begin with belly breathing – as you inhale continue to inhale until both your belly area and then your lower ribs expand with the incoming breath.
- Exhale and feel first your lower ribs contracting and then your belly.
- Make the movement smooth and continuous.
- This phase is sometimes called 2 – part breathing.
Thirds phase or Full Yogic Breath. Feel as you inhale that you are expanding your lungs in all directions, not just in front.
- Continue past the second phase until the upper lungs expand with the inhalation.
- Pause for just a moment with the breath in.
- Exhale contracting the upper ribs, then the lower ribs and finally your belly.
The more you practice, the easier it will be to take deep, full, even and relaxed breaths. The more you practice the more you will benefit and be the calm, healthy person in the crowd.
To find out more about the importance of breathing, in all aspects of your life, check out this inspirational video by the wonderful Cecilia Sardeo of Zenward:
What are you waiting for? If you really want to make an impact on your life, start your yoga breathing now!


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Forgotten Ruins? The castles of the Welsh Princes
By Euryn Rhys Roberts
Y Cylchgrawn Hanes Digital History Magazine, Vol.8 (2014)
Introduction: Of all the ancient monuments that survive from the Middle Ages, none, perhaps, fire our imagination as much as the castles of that era. Unlike the dusty, abstruse documents that have survived from the period, we will all almost certainly have seen if not visited a castle at some time or another. In the British Isles, and particularly in Wales, the landscape is dotted with castles of all shapes and sizes, some made of stone, others of earthwork. And in view of the fact that over 400 castles were built in Wales between the arrival of the Normans in 1066 and the 'Acts of Union' of Henry VIII (1536–43), it is easy to see why Wales was often referred to as 'the land of castles'. According to the results of a survey published in 2011 by Visit Britain, the tourism agency of the Westminster government, a tour of the castles of Wales was more popular among foreign tourists than watching a football match at Old Trafford, shopping at Harrods, and even a visit to Buckingham Palace. So what is the attraction? As we marvel at magnificent castles such as Caernarfon, Caerphilly and Pembroke, we find ourselves transported back to a world of romance and of raw power, to a world of people under siege and of attackers subjected to a shower of arrows and boiling oil. These buildings have done so much to embed popular ideas about the period, and are responsible to some extent for the tendency to portray the Middle Ages (perhaps unfairly) as an uncivilized and cruel age. As someone who used to travel to school along a road affording magnificent views of Rhuddlan castle, I must admit that I hardly took any notice of the castle, despite the fact that it stands head and shoulders above most of the modern buildings in the area. I later came to realize that the castle has a very rich history, as do the remains of Wales' other castles.
In the case of Rhuddlan castle, it was one link in a chain of fortified stone castles built from Aberystwyth in the west to Flint in the north-east by Edward I (d. 1307), king of England and conqueror of Wales, during the last decades of the thirteenth century. Edward invested heavily in establishing castles on his new lands, spending over £9,500 on fortifications at Rhuddlan alone, not to mention a further estimated £60,000 on castles at Beaumaris, Caernarfon, Conwy and Harlech. In view of the sums paid for some footballers today, a few tens of thousands of pounds may not seem like a vast amount of money, but we must not forget that this expenditure must be multiplied many times over in order to arrive at an estimate of the actual cost (£1 today would be closer to £500 in 1280!). Fortunately, many of the accounts detailing the costs of the castles have survived, and, if studied carefully, historians are able to use them to form an outline of the building work undertaken and the background of the builders.
The ruins of the castles of Edward I, and the records kept by the English exchequer, are a reminder of the costly efforts to keep the Welsh under the control of the Crown in the Middle Ages. There is therefore a strange tension relating to the royal and Anglo-Norman castles built in Wales. Guto'r Glyn (d. c.1493), one of the most prominent of the medieval Welsh poets, considered Caernarfon castle to be one of '[c]aerau Edwart Gwncwerwr' ('the forts of Edward the Conqueror'). And later, the antiquary Thomas Pennant (d. 1798) described Caernarfon castle bluntly as 'the most magnificent badge of our subjection'. The magnificent castles of Edward I were therefore symbols of oppression to some, and one can well imagine that creating this feeling of intimidation was one of the primary reasons for building them in the first place. But we must not forget that it is their dignity, rather than their sense of terror, that accounts for the castles of Edward I being designated World Heritage Sites by UNESCO in 1986, as well as the fact that they attract so many tourists and visitors in the twenty first century.
Click here to read this article from Aberystwyth University
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text:
MySneakers App
Whether you're into sneakers or not, MySneakers is a fun and informative application for everyone. Developed by Brooklyn native Louis W. Colon III, MySneakers became a hit app on the iPhone. "Sneakers is an individual thing. It's something we grew up doing, and it becomes a part of fashion. It's a part of style- a part of your individual taste," says Colon. "Some people just want a running shoe to be casual. Others want a Jordan shoe to be reminiscent of Michael Jordan. Some people just want a fashion shoe while others wear Van skate shoes."
Colon is more than just an aficionado; he's a professional expert unlike the many self-titled "sneaker heads" we come across on a daily basis. A few years ago he launched the magazine Kicksclusive and later opened a sneaker boutique in NoLita called Laces. Before launching MySneakers, he worked with the product development team at New Balance in Boston! -Mercedes
To find out how the MySneakers app works, watch our segment by clicking on the photo above.


text:
I'm A Little Seed
(to the tune of "I'm a Little Teapot")
I'm a little seed, brown and flat,
I'm a little seed, brown and flat,
I haven't got a front, and I haven't got a back.
When I get bigger, plant me in the earth,
I'll grow to be a tomato, while you play!
- I'm a clever tomato, yes it's true
- Here's an example of what I can do
- I can change my color from green to red.
- Just pluck me off and eat me up.


text: Our team at Jardine Motors Audi have been tasked with the challenge of raising money for our charity Whizz-Kidz by restoring an old Audi to its former glory. Whizz-Kidz work hard to transform the lives of disabled children by providing the vital equipment, support and life skills they need to reach their full potential; therefore we wanted to help them. We began our journey by looking for our ideal car. The car we wanted to buy was an original UR quattro. Clearly as this is such an iconic car with immense demand, buying one proved more difficult than expected. We were fairly open minded when deciding what to buy but two essential features were that the car was right hand drive and had the iconic Mars Red paintwork. After contacting multiple classic car dealers, owners clubs and spending hours and hours searching the web, we thought we'd hit the jackpot. We came across the perfect looking car which wasn't too far away. We decided to go and see it, however, we noticed that the chassis number didn't match that of the V5. The search continued without much luck; several cars came along but all with a story, write-offs etc. At this point, we were close to giving up on the idea of restoring a car for the Audi Division. Out of the blue, team member Phil came across a car and let us know straight away - it had only just been advertised, so we gave the seller a call immediately and secured it over the phone. It didn't seem like the smartest thing to do, but at this point we were desperate. Thinking back to it, we were really lucky as the man selling told us that his phone was ringing non-stop with people who wanted to buy the car. Thanks to his enthusiasm and interest in our project, we sealed the deal and will be sure to keep him updated on the vehicle's restoration. Our extensive search concluded that the car is both rare and special, therefore finding one that hadn't already been restored or was far too damaged to salvage proved to be more difficult than expected. The car: A 1984 UR Quattro in original Mars Red, packing some punch from the classic and iconic 2 litre, 5 cylinder engine. The car looked stunning - it's not something you often come across, but for a 30+ year old Audi it didn't look too shabby. The first drive was interesting to say the least, a combination of fairly good performance with very little braking power. It seemed the car had been idle for a while and had therefore seized up somewhat, but it didn't take away the fact that it was still such a special car to drive. Stripping down: The car arrived back at Tamworth Audi and after initial inspection, we all knew we had a big job on our hands. We began stripping the car in the following order: Wheels and brakes Front and rear suspension Rear sub-frame and differential Front sub-frame Interior Wiring loom Engine and gearbox Remaining trims and door electrics Initial complications: Surprisingly, there weren't many! Nearly all nuts and bolts came off trouble-free, so no need for cutting off rusted bolts. It was a huge relief as this particular part of the process could have been much more time consuming than it was. Our main issues occurred when we attempted to remove the wiring loom and interior trims. As a result of them being over 30 years old, the plastic had become particularly brittle and embedded. At the moment, we're not 100% sure of the extent of the damage to the wiring loom but we may need to source a new one. As well as trying to get hold of a wiring loom, we're currently finding it very difficult to source the smaller parts: interior trims, seat fabric, roof linings etc. If anyone could help by pointing us in the right direction for these, we'd be massively appreciative. What's next: Engine strip and access damage – currently the engine looks to be in a good shape but further inspection will tell whether there is additional unseen damage. Deep clean on all engine components – 30 years of dirt and grime to remove through steaming and sand blasting. Body shop – paint and bodywork look relatively okay; small areas of rust may lead to further complications, but we won't know until the car has been stripped back to the bare metal. Sourcing parts – we are struggling to locate rare original parts for a reasonable price. That's it for now - we'll be posting weekly to keep you updated on our progress. If you have any questions then please let us know, or if you know anyone who could help us (especially when it comes to sourcing parts!) that would be great.


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21 Bunk Bed Ideas for Instant Inspiration!
Fan Spotlight: These Family Handyman readers put their woodworking and carpentry skills to good use, designing fun and functional bunk bed plans and beds for their kids, their guest rooms, and themselves. Check out these 20 bunk bed designs and get inspired to build your own DIY bed.
Bunk Bed Plans: Bunk Bed with Stairs Storage
"Bunk bed storage stairs built from poplar plywood, pine trim and oriental ginger stain…matched the bed perfectly." – submitted by Facebook fan Daily Wood. This bunk bed features useful storage shelves built right into the stairs!
Bunk Bed Plans: A Playhouse Bunk Bed
This adorable bunk bed, shared with us by Facebook fan Nicolas Csonka, doubles as a child's playhouse or indoor fort, complete with tiny door and window.
Jeep Kids' Bed
Facebook fan Ben Yost shared this red Jeep bed with us. Kids can drive by day, and sleep at night.
Bunk Bed Plans: John Deere Bunk Bed 1
This easily makes the list for amazing bunk beds. For the die-hard John Deere fan, this tractor-inspired bunk bed has all the bells and whistles. Josh & Katie Yingling shared this DIY kids' bunk bed with us on Facebook.
Mini Pickup Truck Bed for Kids
You might think "truck bed" refers to the back of a pickup truck, but in this case, we're talking about a kids' bed made to look like a pickup truck. "Made my son a truck bed modeled after my own truck." – submitted by Facebook fan Doug Goodrich
Bunk Bed Plans: John Deere Bunk Bed 2
Joanne Laurie shared this variation of the John Deere bunk bed with us on Facebook. This DIY toddler loft bed features a cozy reading nook underneath, and a fun tractor design using some amazing bunk beds plans from Ana White.
Lighted His and Hers Bed
"Finished: His and hers headboard with independent integral lights. The LEDs are dimmable, perfect to read by, and it only casts the light on one side, so it doesn't keep my wife awake. This means you don't need a bed side light. The switches are hidden in the middle to make switching both off easier." – submitted by Facebook fan Gareth Dawe
Simple Twin Bed
Adam Conkle built this beautiful, simple twin bed for his toddler daughter and shared it with us on our Facebook page.
DIY Crib and Changing Table
"This is a crib and changing table/dresser set that I made for my daughter. The wood came from trees off our property that I cut down and milled up. These are the first pieces of furniture I have ever built." – submitted by Facebook fan Jeremiah Gilmour
Porch Day Bed
This day bed would be the perfect spot for an afternoon nap on a warm summer day! Facebook fan Dan Geren created this bed/couch combo for his front porch.
Bunk Bed Plans: John Deere Bunk Bed 3
"A John Deere bunk bed I built for two farm loving boys…" – submitted by Facebook fan Daily Wood
Built-in Sleeping Nook
This built-in kids' bed from August M. Botelho is a cozy sleeping nook, complete with curtains for a faux-canopy feel.
Bunk Bed Plans: Classic Bunk Bed With a Twist
Facebook fan Joe Rubino built this set of amazing bunk beds from scratch for his sons. The simple, timeless design features a larger bed on bottom. Discover under bed storage ideas.
Bunk Bed Plans: Triple Decker Bunk Bed
"Triple bunk bed for the visiting grandchildren in 'cabin chic.'" – submitted by Facebook fan Keith Mealy
Bunk Bed Plans: A Castle Bed
"A castle bed project for my son – I've continued to add to it over the years, first with a stairway that included drawers for storage, a hidden play area accessible behind a 'secret' swinging bookcase, and a trap door, and later a set of towers that could serve as storage/book cases or as a climbing tube. Most recently, I built a work bench with lighting and storage for his Lego supplies. I'm still adding details now and again, but he sleeps in it every night!" – submitted by Facebook fan Tim Miller
All homes come with some assembly required…
Now headaches aren't included. Introducing the DIY University. Try it FREE!


text:
Lancastrians are being urged to have their say on issues which are important to their lives as part of a BBC radio project that will be archived in the British Library.
The Listening Project, broadcast on BBC Radio Lancashire and BBC Radio 4, is based at Lancaster Castle until next Tuesday and is open to the public from 9am-4pm.
A custom-made trailer is being used as a mobile recording studio, where people can have conversations about topics that matter to them.
Producer Claire Ashmore said: "It's so exciting to have the opportunity to record an oral history of real Lancastrians.
"There is such diversity across Lancashire and everyone has their own fascinating conversation to share.
"I'd urge as many people as possible to pop over to the castle and say hello to the team."
The Listening Project is travelling all over the UK to hear ordinary people's stories, with Lancaster being the first stop in Lancashire.
The conversations will be broadcast on BBC Radio Lancashire later in the year.


text:
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Whatever the Chinese and North Korean leaders discussed, they are keeping their cards close to their chests
ByAndrew Salmon
- June 21, 2019


text:
Universal reference book for medicines
Product name:
Active substance: celecoxib
Type: NSAIDs.
Highly selective COX-2 inhibitor
Manufacturer: PFIZER MANUFACTURING DEUTSCHLAND (Germany) manufactured by PFIZER PHARMACEUTICALS (Puerto Rico) issuing quality control PFIZER MANUFACTURING DEUTSCHLAND (Germany)
hard gelatin, white or almost white, opaque, with markings white on blue stripes: "100" - on one part and "7767" on the other;
the contents of the capsules are granules of white or almost white color.
1 caps.
celecoxib 100 mg
Excipients: lactose monohydrate 149.7 mg, sodium lauryl sulfate 8.1 mg, povidone K30 6.8 mg, croscarmellose sodium 2.7 mg, magnesium stearate 2.7 mg.
The composition of the coating:
titanium dioxide - about 1.7 mg, gelatin - about 58.3 mg.
The composition of the blue ink SB-6018:
shellac 22-27%, ethanol 33-38%, isopropanol 0.5-4%, butanol 4-8%, propylene glycol 3-6%, ammonia water 1-2% lacquer aluminum blue FD & C Blue # 2 based on the dye indigotine (E132) - 24-28%.
10 pieces.
- blisters (1) - packs of cardboard with control of the first opening.
hard gelatinous, white or almost white, opaque, with markings white on yellow strips: "200" - on one part and "7767" on the other;
the contents of the capsules are granules of white or almost white color.
1 caps.
celecoxib 200 mg
Excipients: lactose monohydrate - 49.8 mg, sodium lauryl sulfate - 8.1 mg, povidone K30 - 6.7 mg, croscarmellose sodium - 2.7 mg, magnesium stearate - 2.7 mg.
The composition of the coating:
titanium dioxide - about 1.7 mg, gelatin - about 58.3 mg.
Composition of yellow ink SB-3002:
shellac - 22-27%, ethanol - 33-38%, isopropanol - 3-7%, butanol - 4-9%, propylene glycol - 3-6%, ammonia water - 1-2% the colorant of iron oxide is yellow (E172) - 18-22%.
10 pieces.
- blisters (1) - packs of cardboard with control of the first opening.
10 pieces.
- blisters (3) - packs of cardboard with control of the first opening.
Description of the drug approved by the manufacturer for the printed edition of 2015.
Celecoxib has anti-inflammatory, analgesic and antipyretic effects, blocking the formation of inflammatory prostaglandins mainly due to inhibition of COX-2.
Induction of COX-2 occurs in response to the inflammatory process and leads to the synthesis and accumulation of prostaglandins, in particular prostaglandin E
, with an increase in inflammation (swelling and pain).
At therapeutic doses in humans, celecoxib does not significantly inhibit COX-1 and does not affect prostaglandins synthesized as a result of COX-1 activation, nor does it affect normal physiological processes associated with COX-1 and that occur in tissues, and primarily in the tissues of the stomach, intestines and platelets.
Influence on kidney function.
Celecoxib reduces urinary excretion of prostaglandin E
and 6-keto-prostaglandin F
(prostacyclin metabolite), but does not affect serum thromboxane B
and urinary excretion of 11-dehydro-thromboxane B
, metabolite of thromboxane (both products of COX-1 ).
Celecoxib does not cause a decrease in GFR in elderly patients and patients with chronic renal failure, transiently reduces excretion of sodium.
In patients with arthritis, the observed incidence of peripheral edema, arterial hypertension, and heart failure is comparable to that of non-selective COX inhibitors that have inhibitory activity against COX-1 and COX-2.
The most pronounced effect was in patients receiving diuretic therapy.
Nevertheless, there was no increase in the incidence of increased blood pressure and heart failure, and peripheral edema was mild and passed independently.
When taken on an empty stomach, celecoxib is well absorbed, reaching
in plasma after about 2-3 hours. After taking the drug at a dose of 200 g, C
in plasma is 705 ng / ml.
Absolute bioavailability of the drug has not been studied.
and AUC are approximately proportional to the dose taken in the dose range up to 200 mg 2 times / day;
when using the drug at higher doses, the degree of increase in C
and AUC is less proportional.
Effect of food intake: taking celecoxib together with fatty foods increases the time to reach
Cmax by
about 1-2 hours and increases the total absorption by about 20%.
Binding to plasma proteins does not depend on the concentration and is about 97%, celecoxib does not bind to red blood cells.
Penetrates through the BBB.
The average V
in the equilibrium state is approximately 500 l / 70 kg in young healthy adult patients, indicating a wide distribution of celecoxib in the tissue.
Celecoxib is metabolized in the liver by hydroxylation, oxidation, and partially - glucuronization.
Metabolism mainly occurs with the participation of the isoenzyme CYP2C9.
Metabolites found in the blood are not pharmacologically active against COX-1 and COX-2.
The activity of the CYP2C9 isoenzyme is reduced in individuals with genetic polymorphism, such as polymorphism homozygous for CYP2C9 * 3, which leads to a decrease in enzymatic activity.
Celecoxib is metabolized in the liver, excreted in feces and urine in the form of metabolites (57% and 27%, respectively), less than 3% of the accepted dose - in unchanged form.
At repeated application T
is 8-12 hours, and the clearance is about 500 ml / min.
At repeated application C
in plasma it is reached by 5 day.
The variability of the main pharmacokinetic parameters (AUC, C
) is about 30%.
Pharmacokinetics in special clinical cases
In patients older than 65 years, the mean C
and AUC of celecoxib are 1.5-2 times higher, which is more due to changes in body weight than in age (in older patients, as a rule, a lower average body weight is observed than in people of a younger age, so they, with other conditions being equal, achieve higher concentrations of celecoxib).
For the same reason, older women usually have a higher plasma concentration of the drug than older men.
These features of pharmacokinetics, as a rule, do not require dose adjustment.
However, in elderly patients with a body weight below 50 kg, treatment with the lowest recommended dose should be started.
The representative Negroid race AUC of celecoxib is about 40% higher than that of Europeans.
The causes and the clinical significance of this fact are not known, therefore it is recommended to start their treatment with the minimum recommended dose.
Violation of the function of the liver.
Concentrations of celecoxib in plasma in patients with mild liver failure (class A on the Child-Pugh scale) vary slightly.
In patients with moderate hepatic insufficiency (class B on the Child-Pugh scale), the concentration of celecoxib in plasma can almost double.
Impaired renal function.
In patients with chronic renal failure with GFR> 65 ml / min / 1.73 m
and in patients with GFR of 35-60 ml / min / 1.73 m
, the pharmacokinetics of celecoxib do not change.
There is no significant relationship between the serum creatinine (or KK) content and the clearance of celecoxib.
It is assumed that the presence of severe renal insufficiency does not affect the clearance of celecoxib, since the main way of its elimination is conversion into the liver into inactive metabolites.
- symptomatic treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis;
- Pain syndrome: back pain, musculoskeletal, postoperative and other types of pain;
treatment of primary dysmenorrhea.
The drug is taken orally, regardless of food intake, without chewing, washing with water.
Since the risk of possible cardiovascular complications may increase with increasing dose and duration of Celebrex
, it should be given as short courses and at the lowest effective doses.
The maximum recommended daily dose for long-term admission is 400 mg.
symptomatic treatment of osteoarthritis, the
recommended dose is 200 mg / day for 1 or 2 doses.
With the
symptomatic treatment of rheumatoid arthritis, the
recommended dose is 100 mg or 200 mg 2 times / day.
symptomatic treatment of ankylosing spondylitis, the
recommended dose is 200 mg / day in 1 or 2 doses.
Some patients noted the effectiveness of the drug at a dose of 400 mg 2 times / day.
In the
treatment of pain syndrome and primary dysmenorrhea, the
recommended initial dose is 400 mg, followed, if necessary, by taking an additional dose of 200 mg on the first day.
In the following days, the recommended dose is 200 mg 2 times / day, if necessary.
Older patients
usually do not need dose adjustment.
However, in
patients with a body weight below 50 kg,
treatment should be started with the lowest recommended dose.
patients with
mild hepatic insufficiency (class A on the Child-Pugh scale),
dose adjustment is not required.
In the case of a
moderate degree of hepatic insufficiency
(class B on the Child-Pugh scale),
treatment should begin with the minimum recommended dose.
Experiments with the use of the drug in patients with
severe hepatic insufficiency
(class C on the Child-Pugh scale)
do not.
patients with
mild to moderate renal insufficiency,
dose adjustment is not required.
The experience of using the drug in patients with
renal insufficiency is not severe
For patients taking fluconazole (CYP2C9 inhibitor), Celebrex
should be given at the lowest recommended dose.
With caution, the drug should be used concurrently with other inhibitors of the isoenzyme CYP2C9.
should be used with caution in patients who are slow metabolizers or suspected of such a condition, since
this can lead to the accumulation of high concentrations of celecoxib in the blood plasma.
In such patients, the initial recommended dose of the drug should be reduced by a factor of 2.
Often (? 1%
Common reactions:
exacerbation of allergic diseases, flu-like syndrome, accidental trauma.
From the cardiovascular system:
peripheral edema.
On the part of the digestive system:
abdominal pain, diarrhea, dyspepsia, flatulence, dental diseases (post-extraction alveolitis).
From the nervous system:
dizziness, increased muscle tone, insomnia.
From the urinary system:
infection of the urinary tract.
On the part of the respiratory system:
bronchitis, cough, pharyngitis, rhinitis, sinusitis, upper respiratory tract infections.
From the skin:
skin itch, skin rash.
Infrequently (? 0.1% and <1%)
General reactions:
swelling of the face.
On the part of the hematopoiesis system:
anemia, ecchymosis, thrombocytopenia.
From the cardiovascular system:
weighting the course of arterial hypertension, increased blood pressure, arrhythmia, hot flashes, palpitation, tachycardia.
From the senses:
tinnitus, blurred vision.
On the part of the digestive system:
From the nervous system:
anxiety, drowsiness.
From the skin:
alopecia, urticaria.
Rarely (? 0.01% and <0.1%)
From the cardiovascular system: the
manifestation of congestive heart failure, ischemic stroke and myocardial infarction.
On the part of the digestive system:
gastric and duodenal ulcers, ulceration of the esophagus, intestinal perforation, pancreatitis, increased activity of hepatic enzymes.
Allergic reactions:
angioedema, bullous eruptions.
From the nervous system:
Adverse reactions detected during post-marketing observations
Allergic reactions:
From the side of the nervous system:
hallucinations, aseptic meningitis.
From the senses:
loss of taste, loss of smell.
From the cardiovascular system:
vasculitis, hemorrhages in the brain.
On the part of the digestive system:
gastrointestinal bleeding, hepatitis, hepatic insufficiency, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, jaundice.
From the side of the urinary system:
acute renal failure, interstitial nephritis, nephrotic syndrome, minimal renal dysfunction.
On the part of the skin:
photosensitization, skin peeling (including with erythema multiforme and Stevens-Johnson syndrome), toxic epidermal necrolysis, drug rash in combination with eosinophilia and systemic symptoms (DRESS or hypersensitivity syndrome), acute generalized exanthematous pustulosis.
On the part of the reproductive system:
violation of the menstrual cycle, decreased fertility in women.
From the respiratory system:
embolism of the pulmonary arteries.
hyponatremia, chest pain.
- bronchial asthma, hives, or allergic reactions after taking acetylsalicylic acid or other NSAIDs, including other COX-2 inhibitors;
- condition after aortocoronary bypass surgery;
- Peptic ulcer in the phase of exacerbation;
- gastrointestinal hemorrhage;
- Inflammatory bowel disease;
- Heart failure (II-IV functional classes according to the NYHA classification);
- clinically confirmed CHD;
- diseases of peripheral arteries and cerebrovascular diseases of severe degree;
- severe hepatic insufficiency (no experience of application);
- severe renal failure (no experience of use);
- Pregnancy;
- lactation period (breastfeeding);
- children's and adolescence under 18 years (no experience of application);
- hypersensitivity to the components of the drug;
- hypersensitivity to sulfonamides.
should be
with the preparation for gastrointestinal diseases (peptic ulcer disease, bleeding history), Helicobacter pylori infection, fluid retention and edema, violations of the liver function of moderate severity, cardiovascular system diseases, cerebrovascular diseases, dyslipidemia / hyperlipidemia, diabetes mellitus, with diseases of peripheral arteries, severe somatic diseases;
simultaneously with anticoagulants (including with warfarin), with antiaggregants (including with acetylsalicylic acid, clopidogrel), GCS for oral administration (including with prednisolone), with selective serotonin reuptake inhibitors (citalopram , fluoxetine, paroxetine, sertraline), with inhibitors of the isoenzyme CYP2C9;
in patients receiving long-term NSAIDs;
in patients who are slow metabolizers or are suspected of such a condition.
Clinical experience with celecoxib during pregnancy is limited.
The potential risk of using Celebrex
during pregnancy is not established, but can not be ruled out.
In accordance with the mechanism of action, with NSAIDs, including celecoxib, some women may develop ovarian changes, which can lead to complications during pregnancy.
Women who plan pregnancy or are undergoing infertility examinations should consider withdrawing NSAIDs, including celecoxib.
Celecoxib, belonging to the group of inhibitors of prostaglandin synthesis, in case of admission during pregnancy, especially in the third trimester, can cause weakness of uterine contractions and premature closure of the arterial duct.
The use of inhibitors of prostaglandin synthesis in the early stages of pregnancy can adversely affect the course of pregnancy.
There is limited evidence that celecoxib is excreted in breast milk.
Studies have shown that celecoxib is excreted in breast milk at very low concentrations.Nevertheless, taking into account the potential for the development of side effects from celecoxib in the infant fed, the feasibility of abolishing either breastfeeding or taking celecoxib should be considered, given the importance of taking Celebrex
for the mother.
Contraindicated in severe impairment of kidney function.
Contraindicated in severe violations of liver function.
Contraindication: age under 18 years (no experience of use).
, considering the antipyretic effect, can reduce the diagnostic significance of such a symptom as fever, and affect the diagnosis of infection.
Influence on the cardiovascular system.
Celecoxib (like all coxibs) can increase the risk of serious complications from the cardiovascular system, such as thrombosis, myocardial infarction and stroke, which can lead to death.
The risk of these reactions may increase with the duration of the drug, as well as in patients with diseases of the cardiovascular system.
To reduce the risk of these reactions in patients taking Celebrex
, it should be administered at the lowest recommended doses and for the shortest possible periods.
The attending physician and patient should keep in mind the possibility of such complications even in the absence of previously known cardiovascular symptoms.
Patients should be informed of the signs and symptoms of adverse effects on the cardiovascular system and the measures to be taken if they occur.
When using NSAIDs (selective inhibitors of COX-2) in patients after an operation of aortocoronary shunting for the treatment of pain in the first 10-14 days, an increase in the incidence of myocardial infarction and cerebral circulation disorders is possible.
Due to the weak effect of celecoxib on the function of platelets, it can not be a substitute for acetylsalicylic acid for the prevention of thromboembolism.
Also, therefore, antiplatelet therapy (eg, acetylsalicylic acid) should not be discontinued in patients at risk of developing thromboembolic complications.
Like other NSAIDs, celecoxib may lead to an increase in blood pressure, which increases the risk of complications from the cardiovascular system.
In patients with hypertension all NSAIDs, including and celecoxib should be used with caution. Should regularly monitor the blood pressure at the beginning of therapy with celecoxib and throughout the course of treatment.
Impact on the gastrointestinal tract.
In patients taking celecoxib, very rare cases of perforation, ulceration, and bleeding from the gastrointestinal tract. The risk of these complications in the treatment of NSAID is highest in the elderly, patients with cardiovascular disease, in patients concomitantly receiving acetylsalicylic acid, and patients with ulcerative lesions of the gastrointestinal tract, inflammatory diseases in the acute phase and in history. Other risk factors of bleeding from the gastrointestinal tract are the simultaneous use of oral corticosteroids and anticoagulants, NSAIDs long period of therapy, smoking, use of alcohol. Most spontaneous reports of serious side effects from the stomach belonged to the elderly and immunocompromised patients.
The combined use of warfarin and other anticoagulants.
It reported serious and some of them were fatal, bleeding in patients who received concomitant treatment with warfarin or similar means. As it reported an increase in prothrombin time, after the beginning of treatment with Celebrex
or change the dose necessary to control the anticoagulant activity.
Fluid retention and edema.
As with other drugs that inhibit prostaglandin synthesis, for a number of patients taking Celebrex
May be marked fluid retention and swelling, so caution should be exercised in the appointment of the drug to patients with states predisposing or deteriorating due to fluid retention. Patients with heart failure or a history of hypertension should be monitored carefully.
Effects on renal function.
NSAIDs, including and celecoxib may have a toxic effect on renal function. It was found that not celecoxib has higher toxicity as compared to other NSAIDs. Celebrex
should be used with caution in patients with renal dysfunction, heart failure, impaired liver function and in elderly patients. Renal function in such patients should be carefully monitored.
Should be used with caution Celebrex
patients with dehydration. In such cases it is advisable to first conduct a rehydration, and then start therapy with Celebrex
The effect on the liver function.
should be used with caution in patients with hepatic insufficiency of moderate severity and administered in the lowest recommended dose. In some instances, severe reactions were observed from the liver, including fulminant hepatitis (sometimes fatal), hepatic necrosis (sometimes fatal or the need for liver transplantation). Most of these reactions occur within 1 month after initiation of celecoxib. Patients with liver dysfunction symptoms or in case of dysfunction of liver laboratory methods require careful monitoring for timely diagnosis of more severe reactions in the liver during the treatment with Celebrex
Anaphylactic reactions.
When receiving the drug Celebrex
cases of anaphylactic reactions have been reported.
Serious reactions from the skin.
Extremely seldom when receiving celecoxib serious reactions were observed from the side of the skin, such as exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis, some of them fatal. Higher risk of such reactions in patients in the early treatment, most reported cases, such reactions started during the first month of therapy. It should stop taking the drug Celebrex
at occurrence of skin rash, changes in the mucous membranes or other signs of hypersensitivity.
SCS therapy.
It can not substitute for corticosteroids or used as glucocorticoid therapy failure.
Impact on the ability to drive vehicles and manage mechanisms
Influence of celecoxib on the ability to drive vehicles and management mechanisms have not been studied. Based on the pharmacodynamic properties and the general safety profile, it seems unlikely that Celebrex
has such influence.
The clinical experience of overdose is limited. There were no clinically significant side effects at single dose of the drug at a dose of 1.2 g and reception in multiple doses up to 1.2 mg / day in 2 divided doses.
in cases of suspected overdose should ensure that appropriate supportive therapy. Presumably dialysis is not an efficient method of removing blood from celecoxib, due to the high degree of binding to plasma proteins.
In vitro studies have shown that celecoxib although not a substrate of CYP2D6, but inhibits its activity. Therefore, there is a possibility of drug interactions with drugs in vivo, which is associated with metabolism by cytochrome CYP2D6.
When concomitantly with warfarin, and other anticoagulants may increase the prothrombin time.
With simultaneous use of fluconazole in a dose of 200 mg 1 time / day of celecoxib marked increase in plasma concentration is 2 times. This effect is associated with inhibition of metabolism by isozyme celecoxib fluconazole CYP2C9. Patients receiving fluconazole (inhibitor of CYP2C9), celecoxib should be used at the lowest recommended dose. Ketoconazole (an inhibitor of isozyme CYP3A4) did not have a clinically meaningful effect on the metabolism of celecoxib.
Inhibition of prostaglandin synthesis can reduce the effect of ACE inhibitors and antagonists of angiotensin II. This interaction should be taken into account when assigning celecoxib together with ACE inhibitors / antagonists of angiotensin II. However, there was no significant pharmacodynamic interaction with lisinopril on the effect on blood pressure.
Elderly patients, patients with dehydration (including receiving therapy with diuretics) or patients with impaired renal function simultaneous use of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors may lead to a deterioration of renal function, including possible acute renal failure. Usually, these effects are reversible.
Previously known NSAIDs, some patients can reduce the natriuretic effect of furosemide and thiazides due to inhibition of renal prostaglandin synthesis, it should be borne in mind when assigning celecoxib.
There was no clinically significant effect on the pharmacokinetics of celecoxib combined contraceptive preparations containing 1 mg norethisterone / 35 mcg of ethinyl estradiol.
There was an increase in plasma lithium concentration by about 17% when co-administered celecoxib lithium. Patients on lithium therapy should be closely monitored in the appointment or revocation of celecoxib.
There were no clinically significant interaction between celecoxib and antacids (aluminum and magnesium preparations), omeprazole, methotrexate, glibenclamide, tolbutamide or phenytoin.
Celecoxib does not affect the antiplatelet effect of aspirin, low-dose received. Celecoxib has a weak effect on platelet function, so it can not be considered a substitute for acetylsalicylic acid assignable for the prevention of cardiovascular diseases.
Avoid the simultaneous application of celecoxib with other NSAIDs (not containing acetylsalicylic acid).
The drug is released by prescription.
The drug should be kept out of the reach of children, dry place at a temperature of from 15 ° to 30 ° C.
Shelf life - 3 years.
The information is provided for your information, do not self-medicate, it is dangerous for your health.
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Claude Debussy – what a wonderful composer! An artist of true musical beauty and complexity. Debussy, perhaps is most well-known for his piano works, so instead I am writing this blog on one of his orchestral works so you can experience a different side to his compositional offerings. Prélude à l'Après-midi d'un faune is a symphonic poem that was premiered in Paris 1894, which was conducted by Swiss conductor Gustave Doret. Translated, the title reads "Prelude to the Afternoon of a Faun" and it was based on Stéphane Mallarmé's poem l'Après-midi d'un faune. This work also provided a basis for his later ballet Afternoon of a Faun which was first performed in 1912. It was also considered a turning point for art music as a genre at the time as it provided scoring that bordered on becoming modern music, as well as the music barely adhering to any sense of tonality or harmonic functions.
The original poem is fundamentally like a free-illustration of a number of scenes where the dreams of a forest faun interacting with nymphs and sharing memories is told. Nature is at the heart of this work and you can certainly hear that in the music within Prélude à l'Après-midi d'un faune. The piece creates a musical sound world that completely absorbs you when you listen to it.
The piece starts with a solo flute playing a whole tone descending sequence, which ends up a tritone below the original pitch. This passage has become a staple for flute players within orchestral repertoire. The purpose of this work, essentially, is to evoke thoughts and imagery from Mallarmé's poem, and Debussy does this by manipulating orchestration and distancing the music from anything functional, thus making it much more accessible for people to have their own creative thoughts on the music. I won't be analysing this piece as much as others, as I do feel its up to the listener to interpret as they wish, and sometimes over-analysing something takes the beauty out of it. However, an interesting part of this piece is the idea of it nearly being in complete free-form, so without any real sense of metre or time. Now upon listening this may be the case, however, once one brings a score into the mix you realise it is an amalgamation of highly complex musical themes carefully intertwined together to create this very balanced feel and atmosphere within the work.
The main theme (heard from the solo flute at the beginning), is developed at length throughout the piece, with different instruments taking the theme and creating their own variation. The work is littered with chromatic harmony changes, whole tone runs (which make it sound very other-worldly!) and metre changes (chiefly between the 9/8, 12/8 and 6/8). The voicing of the instruments is incredibly reflective of nature and Debussy's lack of a tonal centre makes the work innovative and so intriguing to listen to. The main melodies are chiefly led by the woodwinds and horns, with the harps and strings playing accompaniment cells of music to support the sound world being created. This does change at some points in the piece, especially within the more climactic sections of the work. The dream-like atmosphere that is created really highlights Debussy's highly intelligent way of stretching traditional key systems to their limits, without quite distinguishing them.
Prélude à l'Après-midi d'un faune is a prime example of Impressionism and the turn-of-the-century music climate in France. With its advanced sound world and new conception of music as an art genre, this piece uses tonal colour, timbre blending and orchestration to communicate the musical syntax of the piece (even if it is rather hazy!). Debussy is a composer to be admired no end, as his work is so fundamental to that of music eras soon to come (for instance minimalism and impressionism). I do hope you enjoy this piece of music, let it take you away to that special dream world you have!
This Debussy blog is dedicated to my close friend Ben Evans, who I know is a massive lover of Debussy and his music. I hope this blog reaches you in good stead and you enjoy another instalment of Debussy!
Recommended recording:


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JACKSON, MS (WLBT) - Years after his wife was murdered, a Jackson man is still looking for answers. Emmanual Vavaris says he made a promise to his wife that he would do everything he could to get justice.
In 2010, WLBT reported on the murder of housewife and mother, Linda Vavaris. The investigators failed to find any leads. The case soon become stalled, eventually going cold. But now, almost 9 years after her murder, her husband is speaking out.
Emanual Vavaris said there isn't a day that goes by that he doesn't think about his wife, the woman he said was the love of his life.
"I worshiped the ground she walked on," he said.
Everyone that met his wife, Vavarus said, like him, immediately adored her. "Anyone can tell you point-blank that Linda would never have an enemy."
Which is why he can't understand why anyone would want to hurt her.
August 7th, 2010 was no different from the rest. His wife dropped him off at work around 10 p.m. The dogs were in the backseat where they always were.
"We hugged, she got behind the drivers seat, and then left," Vavaris said recalling the night.
Linda pulled into her driveway thirty minutes later. She had just put the car in park when she was shot.
"The gun shot went through the glass and then went into heart, 2 1/2 inches above her heart. She also had money in her hand that was shredded with pellets," Emmanuel said while motioning what is believed to have happened.
As her husband, he said police immediately looked at him first. "They gave me a lie detector test."
Vavaris passed. He was at work and surveillance video proves it.
But Vavaris wasn't the only person police focused on. When she was shot, both her daughter, Carly, and nephew, John, were at home.
According to Vavaris, John found his aunt banging on the driver's side window, calling for help. He immediately took off his shirt and pressed it against her chest.
Investigators brought them in for questioning and, according to Emmanual, "they gave Carly a lie detector test, John a lie detector test, and David a lie detector test." Vavaris said they all passed.
Police later brought in Carly's boyfriend. He too was released. Not long after that, Vavaris said, "the case went cold."
Vavaris did say that, remarkably, his wife was able to give a description of the shooter to police. She described him as being a black male, about 5-feet-9-inches tall, with a noticeable scar on his left cheek.
And video surveillance taken from the home next door captured a black sedan sitting on the street a few feet from the entrance to the driveway.
Vavaris saw the video. "A car was sitting there for 31 seconds. I counted. You can see a man get out of the passenger side of the car, run out of views, return to the car 31 seconds later." The car then sped off.
Vavaris said nothing will bring his wife back. But in order to have closure, Vavaris said he must find the person (or persons) responsible for his wife's death.
Copyright 2019 WLBT. All rights reserved.


text:
A good number of the comments on yesterday's post dealt with today's Manchester United soccer game, where the team will wear a throwback kit in honor of the victims of the 1958 Munich Air Disaster. Setting aside for now the actual looks of the kit, which was disparaged for being boring, it's best to know a little more about the events being memorialized.
The crash claimed 23 lives, including eight Manchester United players and three staffers. To a soccer-mad country — and for a club with a far-reaching fan base — the crash had a particularly devastating effect. Of the players lost in the crash, most notable was Duncan Edwards. Though only 21 years old, Edwards was the star of the national team — hailed as the world's next great football talent. The stained-glass window above is from a church in Edwards' hometown of Dudley, England. Here's a huge version. That's his Man U kit on the left and England kit on the right. Said Sir Bobby Charlton, England's all-time leading scorer:
"He was incomparable, I feel terrible trying to explain to people just how good he was, his death was the biggest single tragedy ever to happen to Manchester United and English football. I always felt I could compare well with any player – except Duncan. He was such a talent, I always felt inferior to him. He didn't have a fault with his game."
To put Edwards' death into perspective related to American sports history, take Ted Williams' first four seasons — ages 20 through 23. Over those seasons, he hit 127 home runs, drove in 515 runs, scored 541 runs, and hit for a .356 average. In 1941, he hit .406. After the 1942 season, he went to war. But what if he didn't come back? What do those stats say about what would have been? Might he be canonized like Edwards? The comparison is apt, though slightly morbid. Edwards' death likely impacted British soccer for the next dozen years, or more.
But on to the kit itself. Though some details aren't quite right — the red stripe seems to be missing from the shorts in this shot — it's a good-faith reproduction. Keep in mind it's just a promo shot. That may not be the final product. Note also, however, that Edwards' image on the left pane above is also missing the stripe. Is it boring? Perhaps, but it was 1958. Things were like that then. And a snazzier kit no doubt could have been chosen, but those players didn't have the luxury of choosing the year of the crash.
Finally, given the historical impact of the event, Manchester United's remembrance might be considered understated — especially when compared to all of those No. 21s for the NFC team in the Pro Bowl today. I'm willing to take the heat for it (that's why I got the bigger inbox for my email), but I'll take a simple, classy, one-time gesture over a press conference memorial any day.
Enjoy your Sunday, folks. — Bryan


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Milk Thistle 50 Capsules
For the relief of symptoms associated with indigestion and upset stomachA traditional herbal medicinal productContains Milk Thistle standardised fruit extractHolland & Barrett Milk Thistle Capsules are a traditional herbal medicinal product used to relieve the symptoms associated with occasional over indulgence of food and drink such as indiges..
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High Strength and Organic TurmericContains Black PepperSuitable for Vegan and VegetariansHolland & Barrett High Strength Turmeric with Black Pepper contains a natural source of Curcumin, which is a plant native to South East Asia. It is a member of the ginger family, and often used as a spice for cooking. Curcumin also gives Turmeric its distin..
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