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How to take DSLR like photos from any Android phone
This post is going to be very helpful for those people who regularly takes selfies or capture photographs. If you want to give your photographs a professional look or want to take photos like the photos taken from a professional camera (DSLR), so you should go through this post. This article is a short tutorial on how to take DSLR like photos from any android phone. Now you may be thinking that, should it possible to take DSLR like photo from any android phone. The answer is simply Yes!. You can take high quality pictures like the pictures taken from DSLRs with background blur. These types of photos are often known as portrait photos. So without any more discussion lets start!
First of all you will need an android app called Google Camera, which is presently not available at play-store, because google has removed it from there. So you can download its latest version here. The performance of this app is fully dependent on your phone's processor and a little bit on the type of camera (how much megapixel it is) you have in your phone and it only works good within a length of 10 feet. After downloading it, simply install it in your smart phone and run it. After running it, slide it from left to right. You will see this type of screen, and then tap on Lens Blur.
Now from here you will need patience because it is not too easy also. Now for taking the photo with background blur you have to keep the object centered, it means that you have to make the object stable of which you want to take the photo and in a proper light. Now the second step is to press the capture button without moving the phone and very slowly raise the phone upwards with keeping in mind to make the object centered. Now if the app shows tick mark, then your image is going to shock you with its stunning photography and it looks like the photo captured from a DSLR. Or if shows cross mark then try again until you capture the perfect one.
Some images to help you out:
So, I hope you have loved this post very much and you will share it too with your friends and family and this too helped you. Please comment your queries and suggestions below in the comment box. Dont forget to SUBSCRIBE to our newsletter to get latest tech news and health facts. You can also follow us on social media to stay in touch with us. Thanks for reading!


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Located in East Wenatchee, this new 84,000 square foot school was designed to serve 600 students. Core classrooms are equipped and grouped to support a "three sections per grade" configuration. Each classroom grouping focuses on a common multi-use space for large group and project-based activities.
The library and student commons are building focal points, positioned near main entries for easy access, supervision and segregation of non-community areas during after-hours use. The main office area is strategically located to be central to all areas of the building and site to address security issues.
Site development features playfields and hard surface outdoor fitness areas for school and community use. Safe, separate locations are provided for student drop-off, school buses and parking.
©2019 ALSC Architects. Site Design ©2019 Klündt | Hosmer. All Rights Reserved.

subset: commoncrawl


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Miss Weekender*
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The Miss Bag is the ultimate iconic bag, redesigned by us with a unique twist and protected by a worldwide registered design*.
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You have worked hard all year to have your holiday rest – Why spend it on a spent mattress?
When buying a leisure vehicle, the comfort of the mattress inside is often an afterthought.
Dynamic Custom allows you to maximise your rest and comfort in your Leisure Vehicle with a custom made mattress in any shape or size. Odd sizes are a specialty that Dynamic excels at - Odd sized mattresses, cut corners or tapering sides are easily over come to allow you to get the best night sleep on a mattress that suits you personally.
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Have a comment?
Just want to say "Hi"....
Want to purchase some of my art? (YES! it's for sale)
How about one of the T-shirts?
Email me!
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I was just diagnosed yesterday. My labs came back & biopsies. I've lost almost 40 pounds since mid July. I'm extremely depressed & I feel people don't understand what I'm going through. Am I being dramatic? And the options, I just spaced out while my gastro was talking. I also live with Bi-polar disorder. I am having a pity party for myself & I'll get over it but I'm wondering how you reacted when you got diagnosed. firstname.lastname@example.com
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Casually Fancy
Top: Gap // Pants: H&M // Shoes: SF Vintage Store // Shades: Forever 21
Yes, I finally did it. I decided to cut my hair, short. Well it's short for me since it is the shortest I have ever gone since I was a little girl. And let me tell you, it feels so good and refreshing! I was so hesitant at first, but then I constantly stopped to think about how I've had the same ole' hairstyle for many years now and it was definitely time for a change. Although it's been a bit challenging to learn how to style my short hair, I think it's a perfect look for the Fall, which I am very excited about!
Daisy Hernandez


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Wednesday, April 29, 2009
Make new marketing tools part of your new business strategy.
This creates a significant opportunity to redefine and expand the role agencies can play with their clients. Clients want new ideas to grow their business, but clients are not just saying to their agencies "how can you help us make ads or design a new web site?" They are also saying "how much do you understand about our business in order to help us build a bridge between our brand and our customers?"
Building bridges means understanding the category, the target audience and the company, but it also means understanding how to evaluate and use some of the new marketing tools that are available today. A key role that agencies can play is not only how to use these tools, but, more importantly, how they will impact a prospect's business.
For example, social media marketing is the number one topic in today's marketing press. But agencies should caution clients and prospects to think carefully before they jump in just because everyone else is doing it. Social media is a process, not an event. Agencies can help clients by focusing on how it can impact their business, not just on how to start a conversation using Facebook or Twitter.
The shift from traditional media to online and other new media alternatives is accelerating. But many marketers presume that the rise in on-demand media consumption and lower entry costs make it s better option. Agencies can help clients by looking for new and better ways to analyze their ROI.
E-mail marketing continues to grow in importance, but many experts predict that consumer fatigue from mailboxes overloaded with too many unsolicited and irrelevant offers will force consumer shutdown and rejection. Agencies can help clients by showing how to take advantage of behavioral targeting and other analytic tools to deliver e-mail that is triggered by consumer actions, not their own promotion activity.
Word-of-mouth marketing has become more intentional as a primary marketing tool rather than just as a happenstance event. Agencies should be looking for recommended efforts to generate beneficial consumer conversations through viral marketing and other buzz marketing tactics. At the same time, agencies must caution marketers to be transparent and honest in their efforts, or they will face the wrath of a growing blogosphere.
There is no question that clients need help in understanding how their business can take advantage of new media alternatives. But the ultimate need is not just how to effectively use email, blogs, podcasts, mobile marketing, viral marketing, pay-per-click, user-generated content, Twitter, etc., but how to mix them with traditional media to create the most impact.
Clients need help in understanding how their target audience attitudes, needs and motivations are changing as they adapt to new economic and social conditions. The Internet doesn't just change how we communicate with each other. It is having a profound impact on our shopping and buying habits, as well as our understanding of the world around us and how we relate to each other. The more real insight and information you can provide the prospect for his unique business situation and needs, the better your chances to secure a new client assignment.
There are many other new marketing tools, but when all is said and done, you can't win new business on a regular basis without really smart strategic thinking. Agencies are in the business of selling ideas, first and foremost. And that's how you win new business.
Saturday, April 25, 2009
Are You Using Case Studies The Right Way For New Business?
For many agencies, case studies are simply a device to show off their creativity or versatility. They might have a few words about the client or business situation, but their primary goal has been to present the agency's creative credentials in a specific medium or business category. Today, however, the case study needs to be much more than a creative show-and-tell.
Don't get me wrong. The power of a strong creative story in new business can never be discounted or eliminated. Creativity is the most exciting aspect of our business, and a well conceived idea that is presented in a unique and memorable way will always gather praise and admiration from clients. But the most desirable characteristic an agency can offer to a prospect today is return on investment, so agencies need to build an ROI story into every case study.
In today's 24/7, on-demand, fragmented media environment, marketers are desperately seeking ways to break through the clutter to reach new customers and sustain the attention of profitable customers. They not only need creative messages, they need messages that succeed. Agencies that demonstrate an understanding and a process for how to meet the client's business goals more effectively will have a much higher success rate than agencies who continue to market themselves just as creative experts.
Today, a good case study should articulate the business problem and the strategic as well as the creative solution. But it must also feature the results as definitively as possible. If your client can't or won't offer specifics of a program, be general. But you must give the client prospect some indication of the success of the program for them to transfer its credibility to their specific need.
One tool that is often overlooked is a client testimonial statement touting the effectiveness and/or quality of the agency's effort for their brand. A prominently placed affirmation from the client can lend credibility and power to your case study.
Marketing analytics are not the cure-all for marketers' woes, but they are the next big thing for agency new business prospecting. Are you taking advantage of that fact in your case studies?
Friday, April 17, 2009
Agencies must kick the can if they want to win new business
Clients need help in understanding how their business can take advantage of new media alternatives. But the question is not just how to effectively use email, blogs, podcasts, mobile marketing, viral marketing, pay-per-click, user-generated content, Twitter, etc., but how to mix them with traditional media to create the most impact.
Clients need help in understanding how their target audience attitudes, needs and motivations are changing as they adapt to new economic and social conditions. The Internet doesn't just change how we communicate with each other. It is having a profound impact on our shopping and buying habits, as well as our understanding of the world around us and how we relate to each other.
The more real insight and information you can provide the prospect for his unique business situation and needs, the better your chances to secure a new client assignment. The key words here are "insight" and "unique". Clients don't just need to know how to start writing and maintaining a blog; they need to know if a blog can really have an impact in building preference and advocacy for their specific products and services. To win their trust, and their business, agencies need to take their general sales materials and customize them to speak specifically and directly to one prospect at a time.
Too many agencies try to develop a generic selling story that can be used for all prospects. They try to sell their process, without selling how their process works for a specific client. They assume that the client will automatically see the connection and appreciate its value for their own business. Unfortunately, that doesn't happen. Most clients don't have the time or the inclination to make that intuitive leap. We've got to make it for them.
This means that agencies need to research each prospect, search for some unique aspect of their business situation and give them some insight and direction on how they can grow their business by hiring your agency. If all you have to give them is a generic statement about your agency, you will have a tough time winning their trust and reduce the uncertainty every prospect faces when hiring a professional service.
In other words, kick the canned pitch if you want to win new business.
Friday, April 10, 2009
A Brilliant Strategy Still Trumps Everything Else in New Business
Clients are dealing with a laundry list of challenges – a struggling economy, new competition from all sides, a continued drive for lower costs, and a growing realization of the power that a connected consumer has over their business strategy and success. And many clients are simply overwhelmed by the new digital media options and how to use them to their advantage.
There is no question that social media and other digital marketing tools open opportunities to redefine and expand the role agencies can play with their clients. But when all is said and done, you can't win new business on a regular basis without really smart strategic thinking. Agencies are in the business of selling ideas, first and foremost. I will never forget my conversation with Stan Richards years ago, when he said that the secret to his new business success is that they always try to give the client some new insight, especially if it is an idea that was right under their nose yet they had missed it.
That thought has never been more relevant than today when clients are not saying to their agencies "how can you help us make ads or design a new web site?", they are saying "how much do you understand about our business in order to help us build a bridge between our brand and our customers?"
In recent conversations with marketing directors about how their businesses are faring in today's economic environment, I have been struck by the the fact that many seem more preoccupied with how to use Facebook or Twitter than in researching and understanding how changing customer attitudes are affecting their brand position in the marketplace. This is a great opportunity for an agency to step in and show a client how to find better answers.
In one recent new business meeting, I asked the prospective client if they had done any audience segmentation modeling for ROI and was met by a blank stare. The blank stare was quickly followed by a question "how do you think we should initiate that kind of analysis?" I created an opportunity for an extended conversation on how to segment their current customer base that will have a significant impact on their future marketing strategy. And on mine as well, since I gained a new client.
That conversation reinforced my belief that clients are hungry for ideas, and agencies can win new clients by providing those ideas. Yes, they need help with how to find the ideal marketing mix of creative, technology, new media, and traditional media, but the best media mix doesn't work without a strategy that differentiates the brand and speaks to a real customer need. When all is said and done, smart strategy still trumps everything else.
Wednesday, April 1, 2009
Beyond Advertising - A New Direction for Ad Agencies?
The IBM study asks us to imagine and consider the consequences to traditional agencies in an advertising world where:
- Interactive advertising surpasses traditional mass media vehicles as the preferred advertising format.
- Ad space is sold through auctions and exchanges.
- An advertiser can know who viewed and acted on an ad, and pay based on real impact rather than estimated "impressions."
- Consumers self-select which ads they watch and share preferred ads with peers.
- User-generated advertising is as prevalent (and appealing) as agency-created spots.
Last month, IBM issued a follow-up report based on their conclusion that major advertising trends identified in the previous study are happening at a faster rate than anticipated, while agencies, content owners and distributors have not responded sufficiently to these changes. This 2008 study, titled Beyond Advertising. Choosing a Strategic Path to the Digital Consumer, addresses these changes in more depth and from a very pragmatic perspective. Importantly, this report offers some practical advice to agencies on how to leverage their strengths in the creative area in the near term while they look for ways to adapt their business model and services offering to address the new environment.
Some of their suggested areas for immediate focus are:
- Look for ways to broaden capabilities that can be integrated with traditional services offered by the agency as a way to diversify revenue and build a stronger client relationship at the strategic level.
- Begin to proactively experiment with new tools and services that can deliver and automate ways to analyze ROI.
- Restructure the organization to promote more collaboration by breaking down self-created silos across disciplines.
- Consider partnerships to complement services and expertise that may be lacking today.
- Look for ways to operate more efficiently through workflow automation, automated creative development tools and alternative media buying scenarios or partnerships.
One of their more intriguing suggestions is to redefine the agency role to be that of an "insights broker" that can analyze and integrate cross-platform sets of data to generate actionable solutions that better profile, target and measure ad campaigns. This represents a dramatic change from the traditional mass-oriented approach to analysis and measurement based on reach and impressions-based measures like cost-per-thousand.
The overall conclusion of the study is that agencies will need to adapt to this new environment in order to survive. Even while we must navigate the current economic environment that suggests a limitation on investment, agencies must start to experiment with and build these new capabilities now. The future will not just be the "end of advertising as we know it", it will be the end of the advertising agency as we know it.
To read the complete IBM study, go to this link:


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The Board of Education would like to thank you for your participation in the Kindergarten Planning Survey. We received 299 responses from our community. The feedback provided in this survey will help drive research and planning for future kindergarten programming.
The Kindergarten Committee will utilize this information to guide our next steps. We received 96 specific points of questions or comments and we will work to respond to those items over the next month. The committee plans to make a recommendation to the Board of Education at the March Board Meeting. Any changes in programming are being considered for the 2019-2020 school year and would not be made this school year.
Initial responses from the survey can be found in this presentation: Results from Survey. We will work to create a Frequently Asked Questions document and planning materials as we work through the process.


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3/4 cup – whole wheat flour
1/2 cup – all-purpose flour
1/2 cup – brown sugar, packed
1 teaspoon – baking powder
1/2 teaspoon – baking soda
1/2 teaspoon – salt
1 1/2 cups – cooked quinoa
3 – eggs
1 cup – mashed ripe banana
1/2 cup – lowfat or fat free milk
1 teaspoon – apple cider vinegar
6 tablespoons – peanut butter
3 tablespoons – vegetable oil
2 teaspoons – vanilla extract
1/2 cup – chopped pitted dates or raisins
Preheat the oven to 400°F. Line a standard muffin tin with paper liners.
In a large bowl, stir together both of the flours, brown sugar, flaxseed, baking powder, soda, and salt. Add the quinoa, breaking up the lumps of grains with your fingertips and blending evenly throughout the mixture.
Beat the eggs in a second bowl, then blend in the mashed banana, milk, vinegar, peanut butter, oil, and vanilla. Pour the wet ingredients and the dates or raisins into the quinoa mixture and stir just until no flour remains. Do not overmix—a few lumps are okay.
Scoop the batter into the prepared muffin tin, filling each about 3/4 full. Bake cakes for 25 to 30 minutes, or until golden brown around the edges and a toothpick inserted in the center comes out clean. Let the cakes stand in the tin for 5 minutes before removing from the pan. Serve warm or at room temperature with a glass of milk.
Recipe and image provided the Milk Life campaign, representing the nation's milk companies. MilkLife


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New goal for 2009 is spending less money. So today's photo was Organizing coupons. My old coupon holder was falling apart so I got a plastic one and starting cutting out coupons. Today's shopping trip I saved over $40 in coupons thanks to www.thegrocerygame.com If anyone here should decide to give it a try please use my name as a referral, Sharon McDonald. There is a one month trial period for $1.00. That is what I am doing. First week wasn't bad at all.
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You are looking at 71 - 80 of 27,996 items for
Jules Janick
Tyler J. Simons, Christopher J. McNeil, Aubrey D. Pham, Carolyn M. Slupsky, Mikeal L. Roose and Jean-Xavier Guinard
'DaisySL' mandarins (Citrus reticulata Blanco) grafted to Schaub Rough lemon (C. jambhiri Lush; SHRL) Carrizo citrange (Citrus sinensis Osb. × Poncirus trifoliata L. Raf.; CARR), and Rubidoux Trifoliate [Poncirus trifoliata (L.) Raf.; RUBT] rootstocks were measured to determine their liking by adults and children, sensory properties, and targeted metabolomics over the course of 2 consecutive years. Chemical measurements showed differences in sugars, acids, and ethanol content, whereas a descriptive analysis found variations in sweetness, mandarin flavor, juiciness, and peelability. During both years, adults significantly preferred 'DaisySL' mandarins grafted to CARR and RUBT over those grafted to SHRL (P ≤ 0.05). Children liked the fruit grafted to CARR and RUBT rootstocks significantly more than fruit grafted to SHRL during the first year, but they did not prefer fruit grafted to any rootstock during the second year. This research found that 'DaisySL' mandarins are a well-liked variety of mid-to-late season mandarin capable of filling the seasonal gap between clementine and W. Murcott varieties. We concluded that the rootstock can affect the chemical composition, sensory profile, and consumer preferences for 'DaisySL' mandarins.
Yu Liu, Miao He, Fengli Dong, Yingjie Cai, Wenjie Gao, Yunwei Zhou, He Huang and Silan Dai
The NAC transcription factor is a peculiar kind of transcription factor in plants. Transcription factors are involved in the expression of plant genes under different conditions, and they play a crucial role in plant response to various biotic and abiotic stress. We transferred the ClNAC9 gene into Chrysanthemum grandiflora 'niu9717' by Agrobacterium tumefaciens–mediated transformation. The results of kanamycin-resistant screening, polymerase chain reaction (PCR) detection, and Northern blot analysis proved that the target gene had been integrated into the genome of the target plants. Wild-type (WT) plants and transgenic plants were treated with different concentrations of NaCl, NaHCO3, and drought stress, and physiological indexes, such as antioxidant system activity (superoxide dismutase, peroxidase, catalase), malondialdehyde accumulation, and leaf relative water content, were measured. We also observed changes in plant morphology. The physiological indexes' changing range and extreme values suggested that transgenic plants' resistance to salinity, alkali, and drought stress was significantly higher than WT plants. Transgenic plant growth was less inhibited compared with WT plants, indicating that the ClNAC9 gene increased the resistance of transgenic plants under the stress of salinization, alkalization, and drought.
Masahiko Fumuro
To determine the potential of using own-rooted trees to lower tree height and delay the decline in tree vigor caused by root clogging, the growth, yield, and fruit quality of pot-planted 'Aikou' mango (Mangifera indica L.) trees propagated by air layering and grafting were observed for 8 years after planting. The trunk diameter of the own-rooted trees propagated by air layering (hereafter abbreviated as own-rooted trees) was significantly smaller than that of the grafted trees propagated by conventional methods (hereafter abbreviated as grafted trees), but there were no significant differences in the scion diameters of the grafted trees. Moreover, no significant differences were observed in leaf number or total length of green branches between the own-rooted and grafted trees during the final 3 years. The height of the own-rooted trees was significantly shorter than that of the grafted trees. Although no difference in the fresh or dry weight of the aboveground part and whole tree was observed between the own-rooted and grafted trees, the fresh and dry weights of the underground part of the own-rooted trees were significantly lower than those of the grafted trees. Furthermore, the T-R ratio (the weight of the aboveground part of the tree excluding the leaves/the weight of the underground part of the tree) of the own-rooted trees was significantly higher than that of the grafted trees. Overall, no significant differences in yield or fruit quality were observed between the two tree types, and the average yield per 1 m2 over 6 years was 2.9–3.1 kg. These results indicate that it may be possible to lower tree height, delay the decline in tree vigor caused by root clogging, and prolong the life span of pot-planted trees by using own-rooted trees.
William G. Hembree, Thomas G. Ranney, Brian E. Jackson and Mark Weathington
Camellia L., the most speciose member of the diverse tea family Theaceae, has a long and complex horticultural history. Extensive cultivation and hybridization have produced thousands of varieties of Camellia, including commercially important crops such as cultivated tea, oilseed, and iconic flowering shrubs. Cytogenetics of Camellia and related genera is complicated; chromosome number and ploidy can vary widely between species, and interspecific and interploid hybridization occurs. However, specific information regarding cytogenetics of many species, cultivars, and modern hybrids is lacking. The objectives of this study were to compile a consolidated literature review of the cytogenetics of Camellia and related genera and to determine chromosome numbers, ploidy, and genome sizes of specific accessions of selected species, cultivars, and interspecific and interploid hybrids. A review of the existing literature regarding Theaceae cytogenetics is presented as a consolidated reference comprising 362 taxa. Genome sizes were determined with flow cytometry using propidium iodide as a fluorochrome and Pisum sativum 'Ctirad' and Magnolia virginiana 'Jim Wilson' as internal standards. Chromosome numbers of selected taxa were determined using traditional cytology and were used to calibrate genome sizes with ploidy level. Our results confirmed a base chromosome number of x = 15 for Theeae including Camellia, x = 17 for Stewartiae, and x = 18 for Gordoniae. Surveyed camellias ranged from 2n = 2x = 30 to 2n = 8x = 120, including diploids, triploids, tetraploids, pentaploids, hexaploids, and octoploids. Previously uncharacterized taxa such as Camellia azalea, C. amplexicaulis, C. chrysanthoides, C. cordifolia, C. cucphuongensis, C. flava, C. nanyongensis, and C. trichoclada were found to be diploid. Ploidy was also newly determined for Schima argentea, S. khasiana, S. remotiserrata, and S. sinensis (all diploids). Both diploid and triploid Stewartia ovata were found, and a ploidy series was discovered for Polyspora that ranged from diploid to octoploid. Ploidy determinations were used to confirm or challenge the validity of putative interploid hybrids. Monoploid genome sizes varied among subfamily and genera, with 1Cx values ranging from 0.80 pg for Franklinia to a mean of 3.13 pg for Camellia, demonstrating differential rates of genome expansion independent of ploidy. Within Camellia, monoploid genome sizes varied among subgenera, sections, and some species (range, 2.70–3.55 pg). This study provides a consolidated and expanded knowledgebase of ploidy, genome sizes, hybridity, and reproductive pathways for specific accessions of Camellia and related genera that will enhance opportunities and strategies for future breeding and improvement within Theaceae.
Cunquan Yuan, Zhiyi Qu, Huitang Pan, Tangren Cheng, Jia Wang and Qixiang Zhang
Heterostylous Primula forbesii is an important ornamental flower in China because of its long-lasting flowers and winter bloom. This study aimed to develop markers of expressed sequence tag–simple sequence repeats (EST-SSRs) that are associated with heterostyly and that can be used for molecular-assisted selective breeding in P. forbesii. We investigated 114,474 unigenes and identified 25,095 SSRs in P. forbesii. Dinucleotide repeats (46.14%), mononucleotide repeats (44.65%), and trinucleotide repeats (8.27%) were the most abundant SSRs. Among the 25,095 SSRs, 10,645 SSR primer pairs were successfully designed, of which 130 primer pairs were randomly selected for further amplification validation using eight accessions of P. forbesii; 98 pairs produced clear and stable polymerase chain reaction (PCR) products, and 28 pairs showed polymorphism. Bulked segregant analysis (BSA) was conducted for the F1 population with respect to thrum style and pin style by scanning 28 polymorphic SSR primer combinations. One SSR marker, c64326, linked to the heterostyly trait at a genetic distance of ≈3.70 cM was identified. The marker c64326 was further validated in two populations with an accuracy of 97.92% and 90.63%. The novel and linked EST-SSR markers can be valuable resources for genetic diversity analysis, mapping, and marker-assisted breeding in P. forbesii.
Wenjie Ma, Wen Liang and Bing Zhao
The effects of different relative air humidity (RH) levels under high temperature and accompanying vapor pressure deficits (VPDs) on the physiology, photosynthesis, and anatomy of Rhododendron need to be better understood to help in reducing damage to leaves caused by high temperature. In this study, two Rhododendron cultivars were exposed at 45%, 55%, 65%, 75%, and 85% RH to a treatment of constant temperature at 38 °C for 14 days, resulting in a VPD of 3.64, 2.98, 2.32, 1.66, and 0.99 kPa, respectively. The results showed the least reduction of the net photosynthetic rate (Pn) under 75% RH treatment in R. 'Fen Zhenzhu' (decreased by 79.8%), and under the 85% RH treatment in R. 'Zhuangyuan Hong' (decreased by 75.4%). The decline in relative water content (RWC) was less under the 75% and 85% RH treatments, and electrolyte leakage showed a slight decrease under the 75% RH treatment in the two Rhododendron cultivars. The appearance of the two cultivars under greater RH showed less damage, probably because plants can avoid damage by increasing total chlorophyll content, decreasing stomatal area, stomatal density, and opened stomata ratio, enhancing enzymatic activity and osmoregulation substances, and improving leaf structure. The findings show that greater RH can alleviate damage caused by heat stress and improve thermostability.
Fan Li, Shenchong Li and Qinli Shan
Temperature is one of the main factors that affects the growth pattern of Gerbera hybrida, which shows vast variation in morphology and stress adaptation among cultivars. However, little is known about temperature responses of plant growth among different cultivars. In this study, four cultivars were planted in different growth temperatures to investigate the effect of temperature on plant growth of Gerbera hybrida during their vegetative growth. Results showed that the optimum growth temperature of the four cultivars was 20 °C, of which plant height, root length, biomass accumulation, leaf area, and photosynthetic rate were enhanced significantly. Different cultivars showed diverse temperature adaptation ranges, which were related with their genetic background, and the temperature adaptability of cultivar Autumn was the best among the four cultivars. Temperature also had significant effects on photosynthetic rate, which was the main factor shaping plant growth. Our research provides the basic guidance for the growth temperature control in the cultivation of Gerbera hybrida.
Marisa Y. Thompson, Jennifer Randall, Richard J. Heerema and Dawn VanLeeuwen
Successful commercial pecan [Carya illinoinensis (Wangenh.) K. Koch] production relies on mitigation of alternate bearing, which is a function of pistillate flower production. Mechanisms of floral initiation in pecan are not well understood. Our objective was to assess the impact of select plant growth regulators (PGRs) on return bloom for commercial application in pecan trees grown in the Southwestern United States. A 2-year study evaluated effects of ethephon, aminoethoxyvinylglycine (AVG), and gibberellin GA3 (GA3) on subsequent season return bloom in fruiting and nonfruiting pecan shoots. Cultivars used were mature Western and immature Western and Pawnee. Effects of PGRs on return bloom of nonfruiting shoots were different from fruiting shoots. As compared with untreated control, a GA3 treatment on fruiting shoots of mature 'Western' trees increased the number of flowers per new shoot by 125%. For nonfruiting shoots on the mature 'Western' trees, the number of flowers per new shoot decreased significantly by all PGR treatments and as much as 93% for AVG. In previously nonfruiting shoots on the immature 'Western' trees, a GA3 treatment reduced the number of flowers per new shoot in the next season by 88.2%. Results from immature 'Pawnee' shoots did not show statistically significant differences. The effects of these PGRs on subsequent season flowering in pecan are complex. This study suggests that PGRs can be used to increase or decrease cropload through effects on return bloom and therefore have potential uses for mitigating alternate bearing.


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Use this method to hard reset your Samsung S5230 Star phone: Enter#. Warning! All your data including contacts, messages etc.
will be lost! Copy all your necessary dataContactsMessages etc. to SIM or make backup to your PC before full reset! Take out SIM card before full reset. If you Hard Reset SAMSUNG S5230 Avila. If this was useful, please share to help others and follow us on Facebook, Twitter and Google.
WARNING! Hard Reset will erase all of your data All described operations you are doing at your own risk. Help! This doesn't work Like us on facebook! GTS5230 user manual. ii you will see in this manual: using this manual This user manual has been specially designed to guide you through the functions and features of your mobile phone.
To get started quickly, Use only Samsungapproved accessories Using incompatible accessories may damage your I forgot my security code for my samsung GT S5230. I have trying so many number. Now the phone is block. WHat Answered by a verified Electronics Technician The code will then be reset to 0000. I forgot my security code for my Samsung SPHA620 phone. Hard Reset SAMSUNG S5233 Star. Start by switching device on.
Use this code in dialer# After using this code device will restart. If this was useful, please share to help others and follow us on Facebook, Twitter and Google WARNING! GTS5230. Solutions& Tips, Download Manual, Contact Us.
Samsung Support UK Samsung S5230 Star Hard Reset: Switch off the device then Press Camera Button Power Button Volume up Button together. Samsung GTS5230 Cell Phone User Manual. Open as PDF. of 74 GTS5230. user manual. next. Problems& Solutions. NEED A MANUAL NEED A SAMSUNG CELL PHONE USER MANUAL Cannot find user manual for Samsung Galaxy A3 I need a user manual for my cell phone Apr 30, 2016 Samsung gts5230 reset Patrick Przedziuk. Loading Unsubscribe from Patrick Przedziuk?
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Skullcandy CRUSHER
The Sensation55™ is our patent-pending bass extension driver. Through this driver, the Crusher delivers a powerful and realistic bass experience that transforms your audio into bass you can feel.
Our custom-tuned REX40™ driver is the keystone of Supreme Sound. The REX40™ is designed from the ground up by our world-class audio engineering team and delivers an extremely smooth frequency response with minimal distortion - tuned for your playlist.
Within the construction of the ear cup, our specially designed acoustical porting allows both drivers to move freely, increasing the bass and reducing distortion.
No more bulky in-line amplifier. The new Crusher draws its power from a premium battery (AA) powered amp hidden in the ear cup.
The bass sensation slider on the left ear cup allows you to adjust the sensation levels to your preference or playlist. If you prefer, turn the vibes off completely. You'll still enjoy the REX40™ driver's premium acoustics, minus the powered bass boost.
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Our expansive team of engineers used standardized anthropometric data to develop the Crusher's flexibility and clamping pressure. Crusher incorporates dual ear cup articulation and a precise selection of materials to deliver long-lasting comfort without affecting sound quality.
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Stash and run. Crusher features a foldable hinge design that breaks down to 40 percent its size.
Toss it in the included microfiber travel bag, and your headphone is in safekeeping for wherever you take it next.
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Control the conversation and your tunes with the simple touch of a button.
Class D
40 hrs
20-20 kHz
32 ohms


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I have no idea what movie this little jewel comes from. Something about the daughter of the Gorton's Fisherman knocking over a liquor store, no doubt. I entertained myself by thinking up a few Noirish movie titles that the picture seemed to me to suggest. Can you think of any others?
My Gun Is Rusty (1957)
She Wades by Night (1959)
Drizzle, My Sweet (1944)
The Blue Galoshes (1953)
Ace in the Puddle (1951)
The Blue Galoshes (1953)
Ace in the Puddle (1951)
For You I Drown (1947)
The Tattered Slicker (1957)
Okay, your turn! Send me your suggestions and I'll post them.


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Robin Thomas
This biography of a living person needs additional citations for verification. (August 2019) (Learn how and when to remove this template message)
Robin Thomas (born Robin Thomas Grossman, February 12, 1949) is an American film, television and theater actor, and sculptor. He changed his professional name to his birth name in 2014, but returned to using Robin Thomas in 2015.
Robin Thomas
Robin Thomas Grossman
February 12, 1949
|Los Angeles, California
|Actor, sculptor
Thomas' best-known television roles are as Mark Singleton in Another World[1] (1983–85), and as Geoffrey Wells on Who's the Boss?.[citation needed] He portrayed Paul Kellogg in The Mommies[2]:709 and Nate's father in Life Unexpected[2] and had recurring roles in series such as Murphy Brown, Matlock, and The Division. He appeared in such films as Pacific Rim, About Last Night..., The Contender, Summer School, and The Banger Sisters. He has appeared in such television series as Misfits of Science, Midnight Caller, Party of Five, Pacific Blue, Queer as Folk, Murphy Brown, Life Unexpected, NCIS, NCIS: Los Angeles, CSI: Crime Scene Investigation, CSI: Miami, CSI: NY, Criminal Minds, Franklin & Bash, Castle, Manhattan, Fuller House,and Crazy Ex-Girlfriend, among others.
Personal lifeEdit
Born in Carlisle, Pennsylvania, Thomas attended the Mercersburg Academy and graduated in 1967. Thomas earned a BFA from Carnegie-Mellon University where he was accepted into the drama department as an actor. Transitioning in his junior year to Sociology dept., he graduated from the Art department with a major in sculpture. Upon graduation he moved to New York.[citation needed]
Thomas spent his early years in New York as a carpenter, specializing in renovations of restaurants and apartments.[1] He also worked as a sculptor, creating kinetic works employing plexiglas, stainless steel, teflon, water, oil, air, pumps, motors, and lights. His works were exhibited at the Huntsville Museum of Art, The Three Rivers Arts Festival, and at various galleries in SoHo. He was invited to create works for Tiffany's windows, NYC for two consecutive years. While in NY he started a construction company renovating lofts and apartments to augment his income as an artist.[citation needed]
Select filmographyEdit
- Film
- About Last Night (1986)
- Summer School (1987)
- Memories of Murder (1990)
- Me and the Kid (1993)
- Jade (1995)
- Amityville Dollhouse (1996) (video)
- Star Maps (1997)
- Break Up (1998)
- The Contender (2000)
- Clockstoppers (2002)
- The Banger Sisters (2002)
- Franklin & Bash (2011)
- Pacific Rim (2013)
- Cleaners (2013)
- Svengali (1993)
- Halloweentown (1998)
- Horse Sense (1999)
- Halloweentown II: Kalabar's Revenge (2001) (TV; via footage from "Halloweentown")
- Ambulance Girl (2005)
- Castle (2009)
- NCIS: Los Angeles (2011)
- Switched at Birth (2011–2012)
- 90210 (2011–2013)
- Rizzoli & Isles (2012)
- ^ a b Reichardt, Nancy M. (June 26, 1983). "Robin Thomas has no regrets about acting". The Marshall News Messenger. Texas, Marshall. p. 46. Retrieved 16 August 2019 – via Newspapers.com.
- ^ a b Terrace, Vincent (2011). Encyclopedia of Television Shows, 1925 through 2010 (2nd ed.). Jefferson, N.C.: McFarland & Company, Inc., Publishers. pp. 603–604. ISBN 978-0-7864-6477-7.
External linksEdit
- Robin Thomas on IMDb


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Job Alert: Opportunity Coordinator, Girl Scouts of NE KS & NW MO
Girl Scouts of NE Kansas & NW Missouri serves 23,000 girls and 9,000 adult volunteers in a bi-state 47 county area. The Council is dedicated to the 105 year-old Girl Scout mission of building girls of courage, confidence, and character who make the world a better place. This well-established organization is currently seeking an Opportunity Coordinator (Inside Sales) to join their team. This role supports the East Region and is based in Kansas City, MO Council office. Responsibilities: The Opportunity Coordinator is responsible for successfully culminating recruitment efforts by initiating and pursuing communications strategies and protocols needed to convert prospective members (leads) to registered members. This individual assists in achieving the council's goals for girl and adult membership through implementing membership strategies in assigned areas. Key accountabilities include:
- Convert leads into registered members by: identifying gap areas of opportunity vs interest, ensuring successful placement in opportunities, upselling volunteer roles and girl opportunities, and communicating volunteer eligibility criteria.
- Provide high-quality customer service to both internal and external customers via phone, email and in-person.
- Support the Girl Scout brand by using tools and resources as designed to provide a smooth customer experience for both new and renewing volunteers and caregivers.
- Collaborate with membership team/partners to develop and implement membership growth strategies which are unique to the areas served.
- Ensure the integrity of data that supports the conversion and placement of girls and adults in the appropriate volunteer project and volunteer job campaigns as listed in the opportunity catalog.
- Work proficiently in Salesforce reports and Microsoft Excel to accurately track, address and report out on data quality throughout the membership year.
- Create and maintain an accurate and thorough Opportunity Catalogue with input from membership team partners (Troop Operations, Recruiters, Regional Directors, etc.).
- Support implementation of membership recruiting marketing strategies outlined in the council's strategic plan, annual business plan and/or other council goals primarily through phone and written follow-up contacts with prospective members and community partners.
- Prepare a variety of status reports, including activity, follow-up, and adherence to goals.
- Ensure Girl Scouting is open to all girls and adults by delivering the Girl Scouts message of pluralism and diversity to members of the council.
- Minimum one year demonstrated experience in marketing, sales or customer service.
- Demonstrated knowledge and experience with Microsoft Office, CRM systems (Salesforce is a plus) and social networking.
- Exceptional interpersonal skills with a friendly and professional demeanor.
- Highly organized with strong oral and written communication skills.
- Ideal candidate is goal-oriented, driven, proactive, energetic, and excellent at problem solving.
- Associate's Degree or equivalent work experience required.
- Bilingual skills (oral and written) a plus.
- Must be available for evening and weekend hours.
To apply for or share this position, visit OMNI Human Resource Management.


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Newborn Baby M | Virginia Newborn Photographer
This little lady was so fun to photograph. We were able to get a variety of great images including quite a few beautiful shots with her proud big brother and the whole adorable family. These two siblings are going to have so much fun growing up together! :)
Since these have already been mailed, I just had to share the gorgeous cards that we created to announce baby M's arrival. I love the images thats Mom chose!


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photograph, Kew Photo-heliograph
- Made:
- 1876
The Kew Photo-heliograph. Image SME No. 48; 1876 Catalogue No. 1852.
- Category:
- Art
- Object Number:
- 1992-32/10
- type:
- photograph
- taxonomy:
- visual and verbal communication
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"Wieliczka and Bochnia Royal Salt Mines"- this is the official name of an entry on the UNESCO World Heritage List concerning the salt mines in Wieliczka and Bochnia and the Salt Works Castle. This site was invited, as the only one from Poland, by the UNESCO World Heritage Centre in Paris to participate in a project, financed by the European Commission, titled: "Journeys to the UNESCO World Heritage sites in Europe".
The project is connected to the European Cultural Heritage Year and the Year of Europe-China Tourism which fall on 2018. It aims at creating, for tourists from China, USA and Europe, routes joining the sites from the UNESCO List and centring on 4 themes: ancient Europe, royal Europe, romantic Europe, underground Europe.
The "Royal Salt Mines" are among 9 places in Europe invited to take part in the "Underground Europe" programme, along with such places as: The Falun Mine from Sweden, the Zollverein and Rammelsberg mines from Germany, Banská Štiavnica from Slovakia, the Tokaj Wine Region from Hungary, the champagne cellars from the Champagne province, as well as the mining regions of Nord-Pas de Calais in France and of the Wallonia region in France.
The project was launched at the beginning of 2017 and will last almost 3 years. The organisers and the representatives of the invited sites meet at workshops to plan together and consult the works connected to the project. In the spring, the first workshops took place in the French Champagne province, and the organisation of the second ones was entrusted to the Cracow Saltworks Museum, represented in the project with the full entry.
The workshops took place on 20-23.09.2017 and 33 guests took part in them, also from abroad and including the organisers and delegates from the sites invited. The inauguration of the workshops took place in the Salt Works Castle in Wieliczka and it was honoured by: The vice-marshal of the Małopolska Province Wojciech Kozak, Bochnia Mayor Stefan Kolawiński, Wieliczka Deputy Mayor Piotr Krupa, the representatives of the Wieliczka District Board Łukasz Sadkiewicz and Tadeusz Luraniec, the Deputy Director of the Cultural Heritage Department in the Ministry of Culture and National Heritage Piotr Szczepanowski, and also the Chairman of the Bochnia Salt Mine Zbigniew Rojek. The host of the meeting was the Director of the Cracow Saltworks Museum – Jan Godłowski
The workshop proceedings were held in the conference chambers of both mines, and their main subjects were the preparation of the online tourism information platform, created by the National Geographic, in cooperation with the participants in the project, targeted at the recipients from China and the USA; and the discussion of marketing plan and advertising campaign to be realised in 2018 by the Solimar International consulting company from the USA. The aim of the campaign is a promotion of the platform and of the UNESCO thematic routes during biggest tourist events around the world.
During the workshops, the participants visited the Salt Mines in Wieliczka and Bochnia, the Salt Works Castle (devoting particular attention to the Polish biggest collection of salt cellars), an underground exposition of the Museum and the Graduation Tower in Wieliczka. The guests saw also Cracow, which presented as well, apart from the Royal Route, at least a part of the underground face – the Rynek Underground exhibition and the Smocza Jama (a dragon's den).


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The law provides for a census to be taken not less than five years after the previous census. However, every census requires further legislation which details how a particular census is to be run. A census is taken in Scotland by the Registrar General for Scotland under the Census Act 1920.
The Census (Amendment) (Scotland) Bill
As announced by the First Minister as part of the 2018-19 Programme for Government, the Census (Amendment) (Scotland) Bill (link to the Scottish Parliament website) would amend the Census Act 1920 to allow National Records of Scotland (NRS) to ask voluntary questions on sexual orientation and transgender status/history in the 2021 census and future censuses. The Bill has now been introduced to the Scottish Parliament.
The full set of questions currently proposed to be asked in the 2021 Census can be found on the Plans for Scotland's Census 2021 page. The final proposed questions will be laid before the Scottish Parliament for agreement before the census takes place.
Impact Assessments
To support the introduction of the Census (Amendment) (Scotland) Bill, NRS has published a range of Impact Assessments, which can be viewed below:
- Equality Impact Assessment (incorporates Children's Rights and Wellbeing Impact Assessment) (0.4MB pdf)
- Data Protection Impact Assessment (0.5MB pdf)
- Strategic Environmental Assessment (0.4MB pdf)
- Business Regulatory Impact Assessment (0.1MB pdf)
- Fairer Scotland Duty Impact Assessment (0.1MB pdf)


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USK, Wash. — Authorities say three people died and two others sustained injuries when a vehicle went off a cliff in northeastern Washington state.
The Washington State Patrol says the crash occurred Wednesday evening in Pend Oreille County and that drugs or alcohol was involved.
Police say 33-year-old Aaron P. Pierre of Cusick was driving the Kia Spectra when it went off the road about 5 miles (8 kilometers) north of Usk. He was taken to a local hospital.
Twenty-two-year-old Anthony R. Shirhama was also transported to a local hospital.
Police say three other passengers died. They are identified as 29-year-old Richard A. Torosian of Cusick, 32-year-old Kayleen Sherwood of Cusick; and 29-year-old Nick O'Shan of Usk.


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A committed and persuasive advocate with broad experience in all areas of criminal defence, as well as in international criminal law.
Instructed in a wide range of criminal work, including fraud, drugs, and violence, with experience of representing vulnerable defendants. Undertakes both legal aid and privately funded work as a led junior and junior alone.
Prior to joining Chambers, Sarah was part of the Ao An Defence Team at the Extraordinary Chambers in the Courts of Cambodia. She has experience of genocide, crimes against humanity and joint criminal enterprise in an international context.
Sarah is involved with Chambers' pro bono project with the BPP Streetlaw programme.
Ann Goddard Scholarship from Gray's Inn (2016) and Overseas Scholarship from Gray's Inn (2015).
Member of the Criminal Bar Association, Young Fraud Lawyers Association and Young Legal Aid Lawyers
Please click here for the member's privacy policy.


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Companies in the News: Davey employees help with Hurricane Irma clean-up; Husqvarna expands customer satisfaction guarantee program
More than a thousand employees from The Davey Tree Expert Co. are helping with recovery from Hurricane Irma by identifying tree hazards and removing them to help power companies to restore electricity quickly. Crews traveled to their locations last week so they could be ready to respond quickly after the storm subsided. While waiting for the storm to hit, crews... read more


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Orajet® 3169RA Removable Intermediate Calendered Digital Media with RapidAir® Technology is a 5 year outdoor durability vinyl designed for easy application of short- to medium-term, indoor and outdoor POP advertising. Also suitable for vehicle graphics and partial wraps with simple curves. Orajet® 3169RA adhesive offers easy removal.
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The interdisciplinary field of materials science, also commonly termed materials science and engineering, involves the discovery and design of new materials, with an emphasis on solids. The intellectual origins of materials science stem from the Enlightenment, when researchers began to use analytical thinking from chemistry, physics, and engineering to understand ancient, phenomenological observations in metallurgy and mineralogy. Materials science still incorporates elements of physics, chemistry, and engineering.
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Hospital Program Volunteers
We rely on volunteers to extend our signature RMHC hospitality to our hospital guests. As our volunteer at OCH, you can support families visiting the Family Lounge, Family Laundry Room and go to the bedside with our Happy Wheels Cart.
Our Hospital Programs run seven days per week 8am – 4pm with 4 hour shifts. Volunteers are asked to commit to two 4-hour shifts per month. (We understand some of our volunteers have extended periods away during the year. We welcome everyone when they are available.)
Volunteers must be 18 years of age or older and are required to complete Oishei Children's Hospital Annual Health Assessment, attend Oishei Mandatory Volunteer Orientation with HIPAA training as well as RMHC training.
As a volunteer, you will:
- Welcome and acquaint visitors to the Hospital Programs offerings
- Provide support to patients and families
- Make coffee, stage beverages and snacks
- Organize supplies for the kitchenette and Happy Wheels Cart
- Drive the Cart on the patient floors, visiting patients and families
- Tidy the room and cart: This will include wiping the counters, in the refrigerator, and cleaning small spills. (Heavy cleaning is done by Kaleida staff after hours)
- Clean the toys: in order to keep our visitors safe, we need to wipe off the toys often to prevent the spread of colds and illnesses.


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By merely looking at the records, one might think the Nordonia ice hockey team would have been favored in its first-round playoff game with Kent Roosevelt.
However, it should be noted the Rough Riders struggled while playing in the Greater Cleveland High School Hockey League's Red South Division — a full four divisions higher than the Knights, who play in the Blue South.
The distance between the two programs was reflected in the score.
Seeded 13th in the Kent District, the Rough Riders ran roughshod over the Knights, scoring three goals in each period to send 18th-seeded Nordonia to a 9-1 defeat Monday at the Kent State University Ice Arena.
With the win, Roosevelt improved to 4-26 and advanced to face top-seeded University School Friday at 6 p.m. at the KSU Ice Arena.
The Knights finished their season at 9-19, as they were also eliminated from Baron Cup III by Lakewood, 2-1, in Wednesday's first round game at Brooklyn.
Roosevelt coach Ben Barlow said a commitment to team-based hockey led to the Rough Riders' big win.
"The No. 1 thing we've been talking about the last month is making the extra pass," Barlow said. "If you can pass first and then look for the goal, it gets everybody involved. It's exciting to watch and it's more fun.
"I applaud our kids for following through with that tonight," he added. "On four of our nine goals, we had two assists."
Meanwhile, Nordonia coach Rich Cinalli said his team had nothing be ashamed of.
"Overall, we played a very good game," Cinalli said. "This is the first time in years we've played a state (tournament) game where we kept playing until the end. I think Roosevelt was surprised how hard we played."
Kent Roosevelt's advantage in team speed was apparent early, as the Rough Riders flew toward the Knights' goal early and often.
Rough Riders center Kai Klempp opened the scoring at the 11:23 mark of the first, putting a backhand off a pass from Phil Macomber.
While Nordonia was able to kill off a cross-checking penalty, Roosevelt's attack was constant.
Roosevelt freshman Ethan Steffl scored a pair of goals in quick succession late in the first half. Steffl reacted first to a loose puck in front of the net and put it home at the 3:32 mark, before tapping in a shot on the left post with 2:21 left in the first.
Macomber assisted on all three first-period goals.
Down 3-0 at the first intermission, Nordonia attempted to push the action, but Roosevelt quickly replied.
Roosevelt got a power-play goal from Andrew Jaggers off a big slap shot from the blue line with 10:14 left in the second, followed by a screened goal from Nick Krestan with 9:23 on the clock.
Krestan got his second goal with 4:18 left in the second to engage the running-clock rule, but things got chippy late in the third period.
After two straight Rough Riders penalties, Krestan was hit with a five-minute penalty for contact to the head on Nordonia defenseman Samantha Peters. Nordonia's coaches wanted a game misconduct, which drew a bench penalty.
Roosevelt had to kill off the five-minute major early in the third period, but got short-handed goals from Branden Monroe (13:51) and Steffl (12:30) during the penalty.
Krestan got his hat trick with 4:30 left in the game.
Nordonia was able to avoid the shutout with 25 seconds left, when freshman Brian Sebastian followed his own shot and poked the rebound into the net.
Roosevelt finished with a 26-14 edge in shots on goal.
Knights goaltender Anthony Cinalli had 17 saves in his final high school game.
Roosevelt starting goaltender Zachary Harper had eight saves in the first two periods, while freshman Logan Pfeiffer had five saves in the third period.
Barlow said he knew playing University School would be a very different animal.
"We've had plenty of experience with University School in the last 16 years," Barlow said. "They've got 20 players who all play great hockey. We're going to have a good week of practice and have a lot of fun."


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Extracellular Matrix Alterations in Patients With Paroxysmal and Persistent Atrial FibrillationBiochemical Assessment of Collagen Type-I Turnover
Author + information
- Received October 29, 2007
- Revision received February 13, 2008
- Accepted March 18, 2008
- Published online July 15, 2008.
Author Information
- Eleftherios M. Kallergis, MD⁎,
- Emmanuel G. Manios, MD⁎,
- Emmanuel M. Kanoupakis, MD⁎,
- Hercules E. Mavrakis, MD⁎,
- Dimitris A. Arfanakis, MD⁎,
- Niki E. Maliaraki, MD†,
- Chrisovalantis E. Lathourakis, MD⁎,
- Gregory I. Chlouverakis, PhD⁎ and
- Panos E. Vardas, MD, PhD, FESC, FACC⁎,⁎ (cardio{at}med.uoc.gr)
- ↵⁎Reprint requests and correspondence
: Dr. Panos E. Vardas, Department of Cardiology, Heraklion University Hospital, 71100, Heraklion, Crete, Greece.
Objectives We investigated whether the serum markers of collagen turnover differed in various forms of atrial fibrillation (AF) and in sinus rhythm (SR) in humans.
Background Structural alterations and fibrosis have been implicated in the generation and perpetuation of AF.
Methods Serum C-terminal propeptide of collagen type-I (CICP), C-terminal telopeptide of collagen type-I (CITP), matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinases-1 were measured as markers of collagen synthesis and degradation in 70 patients with AF and 20 healthy control subjects in SR.
Results C-terminal propeptide of collagen type-I and CITP were significantly higher in AF patients than in control subjects (91 ± 27 ng/ml vs. 67 ± 11 ng/ml, p < 0.001 and 0.38 ± 0.20 ng/ml vs. 0.25 ± 0.08 ng/ml, p < 0.001, respectively). Persistent AF patients had higher levels of CICP (105 ± 28 ng/ml vs. 80 ± 21 ng/ml, p < 0.001), but not CITP, compared with those with paroxysmal AF. Patients with persistent AF had lower levels of matrix metalloproteinase-1 but increased levels of tissue inhibitor of matrix metalloproteinases-1 compared with patients with paroxysmal AF (11.90 ± 4.79 ng/ml vs. 14.98 ± 6.28 ng/ml, p = 0.03 and 155 ± 45 ng/ml vs. 130 ± 38 ng/ml, p < 0.001, respectively). Tissue inhibitor of matrix metalloproteinases-1 levels were significantly lower in control subjects compared with those in both paroxysmal and persistent AF patients (102 ± 15 ng/ml vs. 130 ± 38 ng/ml vs. 155 ± 45 ng/ml, respectively, p < 0.001).
Conclusions Serum markers of collagen type-I turnover differed significantly between patients with AF and SR. Furthermore, these markers also differed significantly between paroxysmal and persistent AF patients, suggesting that the intensity of the extracellular synthesis and degradation of collagen type-I may be related to the burden or type of AF.
Recent data from cardiac biopsies of patients with atrial fibrillation (AF) have demonstrated a substantial increase in collagen deposition in the atria of humans with AF as opposed to those in sinus rhythm (SR) (1–3). Preliminary experimental and clinical data suggest that biochemical markers of collagen turnover correlate significantly with fibrosis in endomyocardial biopsies in hypertensive patients (4). However, although such markers have been shown to differ between hypertensive and normotensive individuals, studies of their association with hypertrophy or other echocardiographic parameters have produced inconsistent results (5,6).
Collagen type-I is the major collagenous product of cardiac fibroblasts (7). We assessed the amount of fibrosis in patients with paroxysmal or persistent lone AF using serum analysis of peptides derived from the tissue synthesis (C-terminal propeptide of collagen type-I [CICP]) and degradation (C-terminal telopeptide of collagen type-I [CITP]) of collagen type-I (4). Enzymes that control collagen type-I turnover, specifically matrix metalloproteinase (MMP)-1 and tissue inhibitor of matrix metalloproteinases (TIMP)-1, were also measured (8).
The ethics committee of our institution approved the study, which conformed to the principles outlined in the Declaration of Helsinki. Informed written consent was obtained from all subjects.
The study population consisted of 70 ambulatory patients (age 24 to 78 years) who suffered from lone AF, defined as AF without clinical or echocardiographic evidence of cardiopulmonary disease, including hypertension. The arrhythmia was considered paroxysmal when it was self-terminating in <24 h and persistent when it was documented on sequential 12-lead electrocardiograms, without any intervening periods of SR, for at least 3 months preceding enrollment. Patients with persistent AF had been referred to our department for electrical cardioversion; none had undergone such a procedure before. No patient had permanent AF, defined as sustained arrhythmia despite cardioversion. Twenty healthy subjects in SR with no history of atrial arrhythmias served as a control group.
Exclusion criteria were conditions associated with elevated serum concentrations of myocardial or tissue fibrosis markers, such as liver disease, renal impairment, pulmonary fibrosis, extensive wounds, metabolic bone disease, malignancy, connective tissue disorders, chronic inflammatory disease, and recent infection or surgery. Patients who were over 80 years old or had a pacemaker/implantable cardioverter-defibrillator were also excluded.
Using a case-control study design, serological markers of collagen type-I turnover, echocardiographic maximal left atrial (LA) diameter, and left ventricular ejection fraction (LVEF) were compared in patients and control subjects. Diltiazem and beta-blockers were allowed for ventricular rate control, and all AF patients received the indicated antithrombotic treatment.
All patients were in AF at the time of blood sampling. Blood samples were obtained at the time of the clinical studies and were immediately placed on ice and centrifuged within 1 h. Specimens were stored at −80°C until analysis.
Serum TIMP-1 and MMP-1 levels were assayed by enzyme-linked immunoadsorbent assay with commercially available kits (Human Biotrack enzyme-linked immunoadsorbent assay system, Amersham Biosciences, Piscataway, New Jersey). C-terminal propeptide of collagen type-I levels were determined by a sandwich enzyme immunoassay with a commercially available kit (enzyme immunoassay, Metra CICP, Quidel, San Diego, California), while CITP was measured using the Elecsys β-CrossLaps/serum assay (Roche Diagnostics, Mannheim, Germany). Measurements were performed by personnel blinded to the patients' clinical details. The intra- and interassay coefficients of variation of all assays were <8% and <10%, respectively, in our laboratory.
Statistical analysis
Summary descriptive statistics for continuous parameters are presented as mean ± SD. Categorical variables were compared among the persistent, paroxysmal AF, and control groups using the chi-square test. One-way analysis of variance was used to test whether these 3 groups differed with respect to various continuous parameters of interest. Where findings were significant, post-hoc Tukey tests were performed to pinpoint differences. If the homogeneity of variance assumption was violated, the nonparametric Kruskal-Wallis test was used instead. Stepwise logistic regression analysis was used to assess whether age, gender, LA, and fibrosis markers were independently associated with AF. Age, LA, and fibrosis markers were treated as continuous variables in the model. The thresholds for entry into and removal from the model were 5% and 10%, respectively. Associations between continuous variables of interest were assessed with correlation and linear regression techniques. Values of p < 0.05 were considered statistically significant.
The baseline clinical and demographic features of the study population are shown in Table 1. Thirty-two patients had persistent and 38 paroxysmal AF. There were no significant differences in gender (p = 0.40) or age (p = 0.058) between the AF groups. Control subjects were younger than AF patients (p < 0.001), but were comparable in terms of gender distribution. Patients with persistent AF had lower LVEF (p = 0.038) and a larger LA (p < 0.001) compared with paroxysmal AF patients.
Serum markers of collagen turnover
The findings are summarized in Table 1. Both CICP and CITP levels were significantly higher in persistent AF patients than in control subjects (p ≤ 0.016). Persistent AF patients also had higher CICP levels compared with those with paroxysmal AF (p < 0.001), whereas there was no significant difference in CITP levels (p = 0.57) (Table 1, Figs. 1 and 2).⇓
Patients with persistent AF had lower levels of MMP-1 (p = 0.026) but higher levels of TIMP-1 (p = 0.013) compared with patients with paroxysmal AF (Table 1, Figs. 3 and 4).⇓⇓ Tissue inhibitor of matrix metalloproteinases-1 levels were significantly lower (p < 0.001) in control subjects compared with both paroxysmal and persistent AF patients (Fig. 4). Plasma MMP-1 levels did not differ significantly (p = 0.20) between persistent AF patients and control subjects (Fig. 3).
Finally, in all AF patients taken together, there was a positive correlation between both CICP and TIMP levels and LA dimension (r = 0.635, p < 0.001 and r = 0.563, p < 0.001, respectively) (Fig. 5), while there was a weak, inverse relation between CICP and TIMP levels and LVEF (r = −0.234, p = 0.05 and r = −0.278, p = 0.020, respectively). A positive correlation was also observed between MMP-1 levels and LVEF (r = 0.30, p = 0.012) while there was an inverse relation between MMP-1 levels and LA dimension (r = −0.615, p < 0.001). Logistic regression analysis showed that, among age, gender, LA and collagen markers, TIMP-1, MMP-1, age, and CICP were independently associated with AF (Table 2).
Patients initially presenting with paroxysmal AF often progress to persistent and eventually develop permanent AF. Although the exact pathophysiological mechanisms are poorly understood, persistence of AF is thought to result from atrial remodeling (9,10). However, pure electrical remodeling cannot explain the development of sustained AF (10,11). Atrial fibrosis, a factor with a slower time course, could be involved (3,12,13).
In this study we demonstrated an elevation in CICP and CITP in the AF cohort taken as a whole compared with those in SR. Interestingly, persistent AF patients had the highest serum concentrations of CICP, whereas there was no difference in CITP levels between patients with persistent and paroxysmal AF. Thus, CICP demonstrated a gradual increase from control subjects to paroxysmal and then to persistent AF, but CITP did not, suggesting that the intensity of the extracellular degradation of collagen type-I was insufficient to compensate for its increased synthesis, resulting in augmented fibrosis in patients with persistent AF.
Furthermore, in patients with persistent AF, MMP-1 levels were decreased, whereas TIMP-1 levels were increased compared with paroxysmal AF patients. Levels of TIMP-1 were also higher in paroxysmal AF patients than in control subjects. In addition, control subjects had lower levels of MMP-1 than paroxysmal AF patients but higher levels than persistent AF patients (although the differences did not reach statistical significance). That seems paradoxical, but it could be the result of the activation manner of MMP-1, which depends on the nature of the stimulus and differs in the setting of acute or chronic stimulation (14). Thus, short-lasting paroxysmal AF could result acutely in pressure or volume overload, activating the MMP-1 system, which then becomes compromised with the prolongation and stabilization of the stimulus.
Another interesting finding was that both CICP and TIMP levels positively correlated with LA diameter and inversely related to LVEF, whereas AF patients with a larger LA and a smaller LVEF, probably as a result of a longer arrhythmia duration, had lower MMP-1 levels.
Since our study included patients with lone AF only, we can speculate that the aforementioned alterations were attributable to the arrhythmia itself, and not to the presence or absence of any confounding factor, with a progressive increase in fibrosis from paroxysmal to persistent AF. In addition, the augmented fibrosis, especially in patients with the persistent form of AF, could further suggest that if collagen modification plays a causal role, this relates to both the initiation and the maintenance of AF.
Study limitations and clinical implications
Serum markers of collagen turnover are not heart specific. In addition, we did not support our findings with atrial tissue biopsy data or coronary sinus sampling. However, we made strenuous efforts to exclude subjects with conditions associated with fibrosis.
Despite our efforts to match control subjects with AF patients, the latter were older. However, collagen markers differed significantly between patients with persistent and paroxysmal AF, despite the lack of any significant difference in age, suggesting that age differences did not influence the interpretation of our results.
Serial measurements of collagen indexes after SR restoration to evaluate the potential temporal alterations of collagen turnover are not available, although these data would undoubtedly have been a valuable addition to our study and could have reinforced our findings.
Finally, the small patient sample size does not allow major conclusions regarding the relationship between systemic fibrosis and AF.
Given these limitations, this is the first study to estimate the relationship between AF burden and serum markers of collagen type-I synthesis and degradation, demonstrating a potential role for these markers in AF evaluation.
Serum markers of collagen type-I turnover may provide a noninvasive method of documenting and monitoring both the extent and the mechanisms of myocardial fibrosis in AF patients and of evaluating pharmacological measures designed to treat this arrhythmia. However, further investigation and randomized trials are needed to elucidate the exact role of fibrosis in AF and to evaluate the clinical importance and value of biochemical monitoring of collagen turnover in this clinical setting. Although cardiac biopsy is the gold standard for documenting and monitoring myocardial fibrosis, noninvasive methods offer a particularly attractive alternative that could have a broader application.
- Abbreviations and Acronyms
- atrial fibrillation
- C-terminal propeptide of collagen type-I
- C-terminal telopeptide of collagen type-I
- left atrial
- left ventricular ejection fraction
- matrix metalloproteinase
- sinus rhythm
- tissue inhibitor of matrix metalloproteinase
- Received October 29, 2007.
- Revision received February 13, 2008.
- Accepted March 18, 2008.
- American College of Cardiology Foundation
- ↵
- Frustaci A.,
- Chimenti C.,
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- et al.
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- Coker M.L.,
- et al.


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If you remember last week we started this section of Job which is a dialogue between job and his friends, Eliphaz, Bildad and Zophar. Last week in chapters 3-14 they all were telling Job that it's something Job did and he needs to make it right with the Lord.
So we turn to the second cycle of speeches in chapters 15-21.
We begin with Eliphaz once again who it seems picks up where he left off. Eliphaz starts by saying "Your own mouth condemns you not I you own lips testify against you" (15:6) then he ask Job if he thinks that he is smarter than the Lord because Job demands an answer. Eliphaz says that this is undermining the Lord. Job replies once again stating his innocence and goes on to say that his friends are scorning him.
Next we hear from Bildad who once again tells Job that the Lord is going to punish the evil doer and Bildad adds that the first-born of death is going to be tagging along as well. Job asks "How long will you torment me, and break me in pieces with words?" (19:2) Job then adds that if it is true and he did err that the error remains with him and his friends shouldn't be continually attacking him about it. Job simply want to be able to plead his case before God.
Zophar is the next to offer his two cents, and guess what he says. Zophar gives a whole list of ways that the wicked man is punished by God. saying that this is the wicked man's portion from God. Job replies stating his innocence and saying that the wicked go unpunished all the time but we all end up in the same place, in the ground.
This book is frustrating as none of Job's friends are actually listening to him and they continually harp on the fact that God will punish the wicked, that is all that they are saying. Next week we will pick up with the final cycle of speeches from this group, and I expect it to be exactly the same thing.


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april, 2018
26apr5:30 pm8:30 pmImplant Design: Adaptation to Natural AnatomyPRESENTER: Mark Spatzner, DMD, Periodontist, Montreal, Quebec5:30 pm - 8:30 pm MST Colorado Dental Association
Event Details
PRESENTER: Mark Spatzner, DMD, Periodontist, Montreal, Quebec This presentation will focus on bone height, width and
Event Details
PRESENTER: Mark Spatzner, DMD, Periodontist, Montreal, Quebec
This presentation will focus on bone height, width and sloped ridges. An array of therapeutic options is available for managing these scenarios, including ridge augmentation, sinus augmentation in the maxilla, nerve repositioning in the mandible. Short or narrow implants have been systematically evaluated as minimally invasive alternatives to bone augmentation in sites with vertical or horizontal alveolar ridge atrophy with favorable clinical outcomes. Sloped implants may also be applied for situations with sloped crest or for immediate placement into sockets with scalloped bone. Specially designed implants are able to adapt to the compromised anatomy, engaging 100% of the implant in bone without the need for bone augmentation. The clinical versatility and success of these products will be the focus of this presentation paying particular attention to the biomechanical, surgical, prosthetic and esthetic considerations.
At the completion of this course, participants will be able to:
- Recognize the role of implant biology, biomechanics and surface technology and how it relates to longevity in successful implant therapy.
- Understand how advancements in technology are allowing for simpler and more predictable incorporation of implant therapy into the practice.
- Recognize the significant changes in implant design that affect surgical and restorative outcomes.
(Thursday) 5:30 pm - 8:30 pm MST
Colorado Dental Association
8301 East Prentice Avenue, Suite 400, Greenwood Village, CO 80111
DISC (Denver Implant Study Club)firstname.lastname@example.com
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MILWAUKEE, Feb 7, 2019 – Johnson Controls introduces the latest version of its Kantech EntraPass Security Management Software with new features relating to short range wireless technology, multi-factor authentication for mobile cardholders and an improved web client user interface.
EntraPass v8.0 software offers several enhancements to the EntraPass Go and EntraPass Go Pass mobile apps. EntraPass Go, which allows remote use of the EntraPass software, provides support for American Dynamics network video recorders (NVRs). EntraPass Go Pass mobile credential now supports Bluetooth Low Energy (BLE) capabilities in ioSmart Multi-Technology Readers. EntraPass operators can choose to ignore BLE technology, enforce BLE or use a combination of both when appropriate. Multi-factor authentication is also available for EntraPass Go Pass cardholders presenting at any door with an ioSmart reader. In addition to the existing card and PIN authentication, biometric data can be used as a second form of authentication offering an added level of identity protection with more secure access to doors using a mobile phone.
"In some cases, ioSmart readers in combination with EntraPass Go Pass multi-factor authentication can replace the need to install an expensive biometric reader", said Gabriel Labrecque, Product Manager, Kantech Software/ Integrations, Building Technologies & Solutions, Johnson Controls. "On a per door basis you can disable the card reader, meaning that only EntraPass Go Pass will be allowed to unlock the door through the use of biometric verification from the phone itself."
EntraPass web, where Silverlight is now no longer an installation requirement, has been redesigned to provide a more efficient and user-friendly interface for an enhanced user experience. For operational speed, graphical icons are more intuitive, tabs replace the dock views and the system remembers the exact position of the most recently opened screen. Setting up hardware components is simplified by a sequential column layout, while the logical visual architecture makes monitoring and changing the hardware configuration direct.
Furthermore making sure installations are cyber secure, ITV2 Type 2 encryption has been added as an integration option for use with both the DSC PowerSeries Neo and PowerSeries Pro intrusion panels.
EntraPass v8.0 is available on Special, Corporate, and Global Editions.
For more information, please visit www.kantech.com.
About Johnson ControlsJohnson Controls is a global diversified technology and multi industrial leader serving a wide range of customers in more than 150 countries. Our 120,000 employees create intelligent buildings, efficient energy solutions, integrated infrastructure and next generation transportation systems that work seamlessly together to deliver on the promise of smart cities and communities. Our commitment to sustainability dates back to our roots in 1885, with the invention of the first electric room thermostat. We are committed to helping our customers win and creating greater value for all of our stakeholders through strategic focus on our buildings and energy growth platforms. For additional information, please visit http://www.johnsoncontrols.com or follow us @johnsoncontrols on Twitter.
About Johnson Controls Building Technologies & SolutionsJohnson Controls Building Technologies & Solutions is making the world safer, smarter and more sustainable – one building at a time. Our technology portfolio integrates every aspect of a building – whether security systems, energy management, fire protection or HVACR – to ensure that we exceed customer expectations at all times. We operate in more than 150 countries through our unmatched network of branches and distribution channels, helping building owners, operators, engineers and contractors enhance the full lifecycle of any facility. Our arsenal of brands includes some of the most trusted names in the industry, such as Tyco®, YORK®, Metasys®, Ruskin®, Titus®, Frick®, PENN®, Sabroe®, Simplex® and Grinnell®. For more information, visit www.johnsoncontrols.com or follow @JCI_Buildings on Twitter.
CONTACTS: Ryan Nolan Global Public Relations Program Manager Building Technologies & Solutions, Johnson Controls Work + 1 414 524 6170 Mobile +1 414 378 9641 email@example.com


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As IT security consultants, we're stuck between a rock and a hard place. Managed IT services providers (MSPs) such as ours want to provide clients with enterprise-level IT, but that requires that we specialize in overwhelmingly intricate technology. Explaining even the most fundamental aspects of cybersecurity would most likely put you to sleep instead of […]
5 proactive defenses against cyberattacks
Protect your data from WannaCry
This month, ransomware has taken center stage yet again. WannaCry has already infected thousands of users around the world. In true ransomware fashion, WannaCry holds user data hostage until the victim decides to pay the ransom. What's more alarming, however, is that the global success of this malware will likely spawn even more potent variants.
How can you go from reactive to preventive IT?
Shopping around for a managed IT services provider is tough. You're looking for a business to manage extremely complex and delicate technology, so they can't be expected to get into the nitty gritty details of DNS-layer security, intrusion prevention systems, and encryption in their marketing content.


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Protein Complexes in Bacteria/
My paper about protein complexes in bacteria is officially published - check it out in PLoS Computational Biology.
Essentially a picture of how many species are not E. coli (except those at the bottom - many of them are E. coli). Click to zoom in or get more context in the linked paper.
The one-sentence summary is as follows: bacteria are different from each other. OK, so that isn't really a mind-blowing observation. Microbiologists tend to think of conserved features in a monolithic way when they're working with multiple species, though, to the point that a ribosome from E. coli is considered more or less equivalent to a ribosome from a Bacillus species or even something exotic like Thermus thermophilus.
Our point here was to show that E. coli protein complexes, on average, don't appear to provide a solid model of those complexes present in other bacterial species. The really well conserved protein complexes tend to be those critical to Life As We Know It (i.e., RNA polymerases), but even among some complexes crucial to one species' existence, a closely-related species may lack one piece of the larger complex.* There's a broader biocomplexity issue here, too: we can't work under the assumption that protein complex components will be consistently co-conserved. Two species may appear to contain a complex of similar function, but one species may put the complex together in a different way than the other.
In some cases, complex parts may even be replaced with those more appropriate to the needs of the species. That's a broader discussion than we attempt in this manuscript but it's an ongoing course of study.
*Lack is a strong word here. If a strain or species doesn't need a certain protein (that is, it's not essential) and it doesn't have any obvious inability to maintain growth in its own environmental niche, does it really lack the protein?


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Oriental Weavers Jasmine 532 W Cream Gold Rugs
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