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Fallout 76 Beta Release Date For PC, PS4, Xbox One Announced
Bethesda has released a new trailer and confirmed the release date of the upcoming Fallout 76 beta. As we previously heard, it'll come to Xbox One before other platforms, but now we know exactly when–the beta begins for Xbox One on October 23 and on October 30 for PlayStation 4 and PC.
In an FAQ for the beta, Bethesda stressed that its purpose is to "stress test and break the game," which means that servers will be "online during targeted timeframes so we can get as many people as possible playing at the same time." Although specific times have not yet been confirmed, the company said the play sessions could last anywhere between four and eight hours. Overall, the beta will go on until a few days before launch.
Bethesda also said that players should expect things to go awry, as beta versions of games tend to do. "The [beta] is a work-in-progress version of the game," it explained. "During the [beta], you will likely see a glorious array of issues; many we know about, and many we don't. Our goal, with your help, is to identify and fix any issues that arise in preparation for the November 14 launch. We need all your suggestions and feedback during [beta], at launch, and beyond to make Fallout 76 the best experience possible, now and for years to come."
To play the beta on PS4 and Xbox One you'll need a PlayStation Plus or Xbox Live Gold membership. Since Fallout 76 is an online title, the final game will also require these subscriptions. The only way to get access to the beta is to pre-order the game at participating retailers or directly from Bethesda.
The beta will weigh in at 45 GB and is not available to pre-load. PC players will not need to re-download the game when it is officially released, but those on console will need to download a launch version. Currently, Bethesda is planning for progress from the beta to carry over to the full game."
Fallout 76 launches in full on November 14 for PS4, Xbox One, and PC. On PC, the game will only be available through Bethesda's own launcher, not Steam. On September 26 Sony announced cross-play functionality is being introduce for certain third-party titles, including Fortnite. However, Fallout 76 is not included among these titles yet.
Bethesda marketing boss Pete Hines said on Twitter: "I work with a lot of devs and games for whom this is important going forward. Fallout 76 does not support cross-play, for a number of reasons. I have no idea if it ever will. But I assure you it is not on our radar right now as we focus on [beta] and launch."
Bethesda has also released the opening video from Fallout 76, which you can watch here or above.
Author: GameSpot


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No, no, he's not dead. He just recently posted his information on Facebook and to see his stuff, I joined, too. I have heard so much about Facebook, I wanted to see first-hand how it worked.
There, you can post your biography, photos, and recent activities that only those you have designated as "Friends" can see. And there's the problem. My short list of friends do not regularly use their computers, and even they would not be interested in my typical activities, such as my colonoscpopy or getting a new pair of long johns.
Norm could not make our reunion, so here is his picture with his brand-new granddaughter. I wouldn't say he looks the same as always, but he looks very good and I could have picked him out of a lineup. I think it is his expression that is familiar after all these years. I would like to know how he kept his hair, but it's too late for me, anyway.
If you have any experience with Facebook, let me know. It could be useful for old classmates to keep in touch, but I don't quite see it for me.
Photos at Flickr.com/photos/MisterEarl/sets

subset: commoncrawl


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system integration
20 years of history
Bestseller world
R&D master
2019-5-6 · Previous Year Question Papers Answer Solution Last 10 Years Entrance Exam Paper Free Download 2019. Question Paper with answer or solution even you can have sample 2019| model papers 2019 | Mock Test Paper 2019 for your exam preparation.Get A Quote
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text: An update on the Siskiyou Complex fire which is the one that imost concerns me. It has been somewhat static for the past few days because of high humidity and little wind. That has inhibited the fire, but it has also inhibited the firefighters from doing their back burning wich is their main weapon against this fire. It is expected that the winds will rise over the weekend and there will also be a chance of more lightening. If the fire cannot be contained behid the line they are setting up, it could move this way very quickly. I do not have much confidence that these houses could be protected. A hot fire in this timber driven by wind can send up a plume thousands of feet high and drop burnoing embers a mile ahead of it. I have been thinking seriously about what I will ltake with me if I have to evacuate. (I do have a pickup which can carry a few things.) I have also been thinking seriously about what it would be like to lose everything else. There are a lot of firefighters preparing and establishing a fireline and they are competant and motivated, but firefighters are helpless in the face of a hot fire and a lot of wind. God is our only real protection. Please keep us in your prayers.


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|Last change on this file since b412038 was b412038, checked in by Chris Johns <chrisj@…>, on Apr 11, 2016 at 3:53:58 AM
|File size: 1.4 KB
Network Task Structure and Data Flow
A schematic diagram of the tasks and message mbuf queues in a simple RTEMS networking application is shown in the following figure:
The transmit task for each network interface is normally blocked waiting for a packet to arrive in the transmit queue. Once a packet arrives, the transmit task may block waiting for an event from the transmit interrupt handler. The transmit interrupt handler sends an RTEMS event to the transmit task to indicate that transmit hardware resources have become available.
The receive task for each network interface is normally blocked waiting for an event from the receive interrupt handler. When this event is received the receive task reads the packet and forwards it to the network stack for subsequent processing by the network task.
The network task processes incoming packets and takes care of timed operations such as handling TCP timeouts and aging and removing routing table entries.
The 'Network code' contains routines which may run in the context of the user application tasks, the interface receive task or the network task. A network semaphore ensures that the data structures manipulated by the network code remain consistent.


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Fiio BTR3 is a Bluetooth receiver, usb dac and headphone amp. It will most often be used to power a wired earphone or headphone and connect by Bluetooth to a phone. It can also be used to add a quality Bluetooth connection to powered speakers and as a usb dac for a computer. High quality built in mic and 11 hour battery life.
Fiio BTR3 has all the latest Bluetooth connectivity codecs, so you will have the best sounding bluetooth connection regardless of the phone or computer source you use: it has AAC (mainly for iPhone), apt-x, apt-x HD (many new android phones and its very good), LDAC and LL (low latency, so the sound syncs with video/skype calls).
The BTR3 sounds better than basic Bluetooth receivers since it takes the signal from the bluetooth chip and runs it through a higher performance dac/amp to drive the headphones. This provides a clearer and more powerful sound.


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NobleCircles Genealogy © Haceldama
NobleCircles Genealogy © Haceldama is a searchable genealogical relationship database consisting of more than 440,000 people and 165,000 families at 30,000 places worldwide all gathered in one single family tree; mapping their ancestors, descendants and various relatives and all of them somehow related to each other. The database also includes all European and some Middle Eastern royal families, many European noble families, 28 US Presidents, 33 British Prime Ministers and all 141 Danish Privy Councillors and Danish Prime Ministers and many of their relatives. You can follow NobleCircles Genealogy © Haceldama if you join our Facebook Page and our Facebook Group. You can at on the Log File see what other people latest looked at in the database, which were last updated on July 24 2019.
Kirsten Møhl1905 - Yes, date unknown
Name Kirsten Møhl Born 3 Nov 1905 Svendborg, Funen, Denmark Gender Female Died Yes, date unknown Person ID I72820 NobleCircles Genealogy © Haceldama Last Modified 27 Jan 2018
Father Johan Conrad Holberg Møhl, b. 1874, d. 1956 (Age 82 years) Mother Julie Viveke "Vigga" Wiggers Kjær, b. 27 Apr 1879, Svendborg, Funen, Denmark , d. 15 Dec 1975 (Age 96 years) Stepparents Married 1901 Children 1. Kirsten Møhl, b. 3 Nov 1905, Svendborg, Funen, Denmark , d. Yes, date unknown Family ID F44533 Group Sheet | Family chart
Family Andreas Vinding, b. 23 Oct 1881, Seem, South Jutland, Denmark , d. 27 Jan 1949, Copenhagen, Zealand, Denmark (Age 67 years) 'Other partners: Antoinette Kathrine Helene "Agis" Nielsen (1903), Anna-Feodora "Luth" Otto (1922) Married 26 Jan 1929 Paris, Paris, Île-De-France, France Children 1. Diana Vinding, d. Yes, date unknownMarried: Svend Bergsøe (Bergsøe) (1967) Last Modified 12 Feb 2016 08:31:00 Family ID F34135 Group Sheet | Family chart


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I would like to use posterization of the image in my program, but unfortunately I don't seem to be able to find an appropriate method in the Magick++ API. I can find the method in the MagickWand API#MagickPosterizeImage, but for the project I'm working on I would prefer to use OOP.
Am I looking in the wrong place or is the posterization missing from the Magick++ API ?
Thank you.
edit: I use Magick++ v6.7.3
Posterize method is missing in the Magick++ API
Magick++ is an object-oriented C++ interface to ImageMagick. Use this forum to discuss, make suggestions about, or report bugs concerning Magick++.
Post Reply
1 post • Page 1 of 1
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We leave on Thursday October 29th and return on Sunday November 1st. My cabin mate is a fellow LTN walker and she has a great personality, so I'm sure it will be a blast. It looks like there are also quite a few people going from our community.
This is the ship~
Here is a our cabin-it was a few dollars more for oceanview, but I think it will be well worth it.
So! Now that I have booked this, I have to lose 27 pounds by October 29th. I refuse to be this size by the time I get on that cruise. If anyone wants to join me in my journey to lose 27-30 pounds, please comment and we can help support each other. If no one wants to join me, I will still be posting my fat ticker results every Friday. I have to stay on plan and make sure that I am accountable for my actions. I have gained alot of water weight this week and that's to be expected, but I my ticker better start moving down again soon.
If you like this post then please consider subscribing to my full RSS feed.


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The Tuscan capital hosts the second edition of the manifestation. Expected, among others, Italian Prime Minister Mario Monti and President of the European Commission Jose Manuel Barroso.
Segreteria Organizzativa
Telefono: +39 055 2719012
E-mail: firstname.lastname@example.com
© 2013 Festival d'Europa 2013. All rights reserved - powered by 72pixel
Please login using your credentials recived by email when you register.
I forgot my password | Resend activation e-mail


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With back-to-school shopping in full swing, a lot of parents are buying new shoes. That's why Nike has launched a new sneaker subscription service. Yesterday, the brand announced that for the first time ever "Nike Adventure Club" will give kids the opportunity to select from more than 100 sneaker styles monthly. This new venture primarily services adolescents from ages 2 through 10 (size 5c-7Y) and is available for as low as $20 for four pairs a year.
"In providing footwear, we're always trying to answer, 'What do kids want?'" Dominique Shortell, director of product experience and retention for Nike Adventure Club, said in a statement. "But an equally important question is, 'What kind of experience are we providing for their parents?' We want to make shopping for footwear as convenient as possible for them," she continued.
Once you receive your sneakers, there is an option to keep them. Or, you can also send them back if you want a new pair. Shoes also won't just go to waste; they're either recycled or donated to select non-profits in collaboration with Nike Grind. An added bonus to the personalized Adventure Club Box: the sneakers come in a kit that features fun, kid-friendly outdoor games activities. For now, you can sign up on Nike Adventure Club's waitlist for the new subscription services.
To join the Nike Adventure Club: CLICK HERE (You will be redirected)
Photo Credit: Nike


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We Searched seven hot Pink soccer jerseys over the past 3 years. Locate which Pink soccer jersey matches you. You can also Narrow by style, Brands, type and product or pick one of our Pink soccer jersey editorial picks.
To avow a Pink soccer jerseys is impartially superior would be improper. Accordingly, in this case, I would like to dig up a little deeper toward the universe of Pink soccer jerseys.


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- Property Type: Unit
- Property Features: Security system, Smoke alarms, Other (security cameras)
- Roof: Coloured steel
- Tenure: Crosslease (fee simple)
- Property condition: Excellent
- Garaging / carparking: Single lock-up, Off street
- Construction: Brick
- Joinery: Timber
- Insulation: Ceiling
- Flooring: Carpet
- Heating / Cooling: Heat pump, Gas bottled
- Electrical: TV aerial, Rewired (Fully rewired)
- Chattels remaining: Blinds, Fixed floor coverings, Light fittings, Stove, Curtains, tv aerial, dishwasher, heat pump, camera outside and inside x2, oven
- Kitchen: Modern, Open plan, Dishwasher, Separate oven, Rangehood, Double sink and Gas bottled
- Living area: Open plan
- Main bedroom: Double and Built-in-robe
- Ensuite: Separate shower
- Bedroom 2: Double and Built-in / wardrobe
- Main bathroom: Separate shower, Exhaust fan
- Laundry: In kitchen
- Aspect: North
- Outdoor living: BBQ area, Deck / patio
- Fencing: Partial
- Land contour: Flat
- Grounds: Backyard access, Tidy
- Water heating: Gas
- Water supply: Town supply
- Sewerage: Mains
- Locality: Close to shops, Close to schools, Close to transport
About this listing
It's an easy bus commute to the CBD appealing to professional couples, retirees, first home buyers and tenants.
Just move in and relax so be quick to secure the Jackpot!!
Please copy and paste the link below into a new browser & register your details
For more information on the property market visit monalisa.nz
Open homes: Sunday 1.00-1.30pm or viewing by appointment


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Tablet Security Stand
Secure tablet mount device compatibility makes it the ideal solution for any display setting whether it's a retail store, corporate office, school lab, restaurant or any open access area.
Product Details
The simple design allows for any mainstream tablet to be secured with minimal interference to the tablet experience. The extendable arm at the rear of the tablet locks in position and is held securely in place with the supplied Kensington style security lock. The 'shoulders' sit corner-to-corner on the tablet and have an inner plastic lining to protect the tablet screen from scratches. The tablet can be rotated 360% for portrait and landscape orientation, and be tilted for the optimum viewing angle. The sturdy base has four screw holes and can be screwed or bolted onto a table or wall for extra security. If you require a security solution for your tablet that offers an unrestricted tablet experience, the secure tablet mount is the perfect solution. Compatible with the Lenovo ThinkPad, Dell Venue, HP Elitepad, Apple iPad, Samsung Galaxy, Google Nexus, and nearly all other 7 – 10" tablets.
Compatible with tablets from 7" to 10"Supplied with 1.5m security cable and Kensington style keyed lock (two keys supplied)
Rotates 360 degrees and tilts
Corner brackets are 1.1cm deep to accommodate most tablets
Holes in mount base to allow securing the mount to the tablet or wall
Extra pad included for extra support with thin tablets
Cable-tidy strap included to tidy power cables etc
Lightweight and extremely durable
Simple to assemble
2 year warranty


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A day after it released a list of district-wise exclusions in the contentious National Register of Citizens (NRC), the Assam government decried the process of verification of citizens that, it said, left out more number of people in indigenous areas as compared to districts bordering Bangladesh having a sizeable Muslim population.
The list, which was released in the state Assembly despite a Supreme Court order to the state coordinator of NRC to submit the details only in a sealed cover, showed the total number of applicants was 3,29,91,385 out of which 40,07,717 names, which is 12.15 per cent, were not included.
It showed that the percentage of non-inclusion of names in districts bordering Bangladesh like South Salmara was 7.22, Dhubri 8.26 and Karimganj 7.67 whereas non-border districts like Hojai and Darrang have the highest non-inclusion rate at 32.99 per cent and 30.90 per cent respectively.
It is believed that the release of the report is seen as a move to pressurise the state NRC coordinator Prateek Hajela to go for a reverification as the draft report, showing low exclusion of Muslims, goes against the BJP's narrative.
ALSO READ: SC extends Assam NRC deadline to Aug 31
"It is a matter of concern that the percentage of names excluded from the draft NRC is higher in the Bangladesh border districts compared to the rest of the state," Assam Accord Implementation and Parliamentary Affairs Minister Chandra Mohan Patowary said.
The NRC coordinator came under fire from ruling BJP members who expressed doubt whether a correct NRC will ever be published.
Citing the list, they said that this is a proof that a section of people residing in border districts of Assam has wrongly been included in the NRC, and slammed the coordinator.
BJP MLAs Debanana Hazarika, Shiladitya Deb and Numal Momin and AIUDF member Nurul Amin raised the issue during the Zero Hour.
They alleged there was gross misuse of the legacy data in various districts, particularly in those bordering Bangladesh.
"Due to this misuse, comparatively fewer people were left out of the draft NRC in those districts", the minister said.
Only seven per cent of the applicants from the Bangladesh border districts have been excluded from the NRC draft list, Hazarika said and asked why the sample verification, as ordered by the Supreme court, was not done.
Deb claimed that only eight per cent people were dropped from the draft NRC in the border district of Dhubri and neighbouring Barpeta, while 14 per cent names were left out in Karbi Anglong, which is not a border district.
ALSO READ: NRC official refutes reports of Rohingya migrant's inclusion in draft
Momin said while 5-7 per cent of the names from the border districts were excluded from the draft NRC, 18 per cent indigenous people were dropped from the list.
Under the Supreme Courts directions, the first draft of the NRC was published on December 31, 2017, and the final draft on July 30 last year, where 40 lakh odd people were left out. The Supreme Court had on July 23 extended the deadline for publication of the final NRC by a month to August 31.
"We want an error-free NRC that will include the names of Indian citizens and exclude the names of foreigners," Patowary said.
Assam, which had faced influx of people from Bangladesh since the early 20th century, is the only state having an NRC which was first prepared in 1951.
(With agencies' inputs)


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Why we should always have some aloe vera gel in the medicine cupboard
My wife regularly gets heat rash (which is a bit embarrassing as a South Indian). The main remedy she uses is aloe vera gel, so I know from experience how incredibly soothing this stuff is. The sap…
Post to Tumblr


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The great Gabriel "Flash" Elorde was one of the all time great Filipino fighters. Today we saw his grandson, Juan Miguel Elorde (28-2, 15) attempt to make the most of an unexpected world title opportunity as he took on WBO Super Bantamweight champion Emanuel Navarrete (29-1, 24). Unfortunately however this wasn't a night to remember for the Elorde family, with "Mig" being dominated by the Navarrete.
From the opening round Navarrete looked a danger, but it was actually Eldorde who seemed to land the best shot of the round, and did much better than expected. It was however, a case of Navarrete looking to see what Elorde had in his arsenal before going through the gears.
Sadly for the Filipino we began to see what Navarete had in the locked when he began to turn up the heat and seemed to wobble Elorde for a second. Elorde was showing his heart and determination, and had decent moments in round 3, though was left bloodied by Navarete's power. That power also earned the Mexican a knockdown in the dying seconds of the round, when the ropes kept the challenger up right.
In all honest as soon as Elorde was wobbled at the end of round 3, it felt like the start of the end, and it would take less than 30 seconds of round 4 for the referee to see enough and stop the Filipino.
For Navarete this was his second win in around a month, a busy schedule to say the least, and there's a chance he could fight again this year. As for Elorde it's really hard to know what his future holds. The Filipino is no youngster and this could be the end for him, in what would appear like a cash out, though he could easily return to Asia and compete on the regional title scene, something he really should have done more before getting this shot.
Last night in the US Tomoki Kameda (36-3, 20) [亀田和毅] fell to his second loss in a boxing ring to Mexican Rey Vargas (34-0, 22), with Vargas successfully defending WBC Super Bantamweight title as a result.
The two men, who had fought in the amateurs, had history coming in to the bout and that history had been on the mind of Kameda in the build up. The Japanese fighter had laid out his plan before the bell, he was going to try and goad the talented Vargas into a fight, and make Vargas give away his advantages.
Sadly for Kameda that game plan failed, badly, and in the ring Vargas did what Vargas does, and used his freakish frame to neutralise Kameda. Vargas was incredibly busy, throwing around 800 punches, and although his accuracy wasn't great, it kept Kameda at range. When the Japanese fighter did get up close, which was rather rare, Vargas snuffed out the problem with some ease, holding spoiling and forcing the referee to split the two men.
Although far, far less busy Kameda did have moments, landing some big right hands. Those shots did little other than catch the eye as his lack of power at Super Bantamweight proved to be another big issue for him.
After 12 rounds there was no doubting the winner, with Vargas comfortably in control for the most part, winning 117-110, with Kameda having been deducted a point late in the fight for punching on the break. It was a deduction that played no real part in the result and seemed to come from frustration in a bout he knew was already out of reach.
Just moments ago fight fans around the globe saw Irish-Australian TJ Doheny (21-0, 15) score his first defense of the IBF Super Bantamweight title, as he stopped over-matched Japanese challenger Ryohei Takahashi (15-4-1, 6) in the 11th round.
Takahashi, a huge under-dog, looked outclassed from the opening moments as Doheny landed sharp shots, moved around the ring well, and found a home for his southpaw left hand, to both head and body. Takahashi was coming forward but his limitations were clear and he was always struggling to get close, never mind actually landing anything of note.
In round 2 the fighters clashed heads, with both being cut on the bridge of the nose, despite the cuts Doheny continued to control the action, dropping Takahashi the following round.
As the fight went on Doheny seemed to slow down a touch, picking his shots a little bit more whilst Takahashi began to ramp up his pressure. That pressure wasn't completely effective, due to Takahashi's technical flaws, inaccuracy, poor footwork and limited technique, but he did have moments and was forcing Doheny to fight at a higher pace than he would have wanted.
The second half of the fight saw Takahashi's pressure become more and more intense, and he arguably took a round or two as Doheny seemed to take his foot off the gas just a touch. It was never as if Takahashi was coming close to winning the fight, but just doing enough to perhaps sneak a round or two.
Sadly for Takahashi Doheny began to move back through the gears as we went into the late rounds, landing some sickening body shots. Those shots began to take a toll and although Takahashi continued to come forward he did look like he has visibly slowed a touch.
In round 11 Doheny managed to rock Takahashi and a follow up forced the referee to step in. It was a strange stoppage, but one that not many will really complain too much with given the noncompetitive nature of the fight. Doheny was in a huge lead going into the round, and there seemed to be no chance of Takahashi landing anything big enough to turn things around, so the stoppage certainly didn't feel like it was robbing the fans, or challenger of anything.
Following the win Doheny was joined in the ring by WBA champion Danny Roman, and they spoke about a unification bout. That's looking likely to take place later this year, though it's possible that both may have to fight a mandatory defense before a unification bout.
For Takahashi this was his biggest fight by far, and it's fair to say whilst he came up short he did put up a brave and gritty effort. He'll be unlikely to get another fight at this level, but he will fit well in the mix at Oriental level when he gets back in the ring.
In recent times the Kyoei boxing gym has been overshadowed by rival Teiken, who have basically been the big success story of Japanese boxing for the last few years. Today however Kyoei claimed their 13th "world champion" as Tomoki Kameda (36-2, 20) [亀田和毅]claimed the WBC "interim" Super Bantamweight title, with a clear decision win over Spanish based Dominican puncher Abigail "bebe" Medina (19-4-2, 10) at the Korakuen Hall.
The first started perfectly for Kameda, who dominated the early rounds with his speed, movement, and ring IQ. In fact through 4 rounds it was almost impossible to even try to make an argument that Medina deserved anything. The Japanese fighter moved too well, landing all the shots of note and really was good value for his 40-36 lead, a score that was publicly announced after the 4th round.
Medina then began to come alive, losing round 5 but looking more live and becoming more and more aggressive, particularly in round 6 and 7, both rounds in which he upped his work rate and forced Kameda on to the back foot. It was good work from Medina, but seemed like it was a case of needing a KO, and by round 8 Kameda had re-found his groove, boxing and moving brilliantly, landing flush combinations. Kameda's performance in round 8 saw him leading 78-74 after 8 rounds, and looking like the man who had began to sort things out.
Kameda again shone in round 9, as he once again found his distance and landed flashy combinations. He struggled to keep up his success however and Medina did enough get himself back into the fight in round 10, but by then he really did need a KO to win, he was too far behind with too little time to catch up to the Japanese fighters.
Knowing if he stayed on his feet the bout was in the bag Kameda knew what he had to do, and saw out the final 2 rounds to take the unanimous decision with scores of 117-111, twice, and 116-112.
With the win Kameda sets up a bout with WBC "regular" champion Rey Vargas, in what could be a very interesting match up. Sadly his lack of power did again rear it's head, and talk of a bout between Kameda and Naoya Inoue, which has been raised recently from Kameda's father Shiro Kameda, doesn't look as appealing with the knowledge Kameda's power really isn't there at world level, unlike Inoue's.
Dogboe stops Otake inside a round!
The month of August hasn't been great for Japanese Super Bantamweights. Back on August 16th we saw Ryosuke Iwasa lose the IBF title to TJ Doheny in Tokyo. On August 23rd Hinata Maruta was held to a controversial draw against Ben Mananquil in the Philippines. That run unfortunately continued this past Saturday when 37 year old Hidenori Otake (31-3-3, 14) suffered his first stoppage loss, being taken out inside a round by WBO Super Bantamweight champion Isaac Dogboe (20-0, 14).
Otake had gone over to Arizona confident, he had spoke about taking Dogboe long and defeating him based on his stamina. That confidence showed as he looked to stand toe-to-toe with Dogboe and take the fight to him. Sadly for Otake that was a mistake as Dogboe was sharper, quicker and more accurate, landing solid uppercuts and left hooks at will.
One of those left hooks was a dynamite shot right on the chin, sending Otake down hard. The Japanese fighter, who had proven toughness, got to his feet at the count of 4 and went on to the front foot, trying to take the fight to Dogboe. It was a mistake and he was forced to touch down again only moments later.
Otake continued to fight but was totally unable to avoid the left hooks from Dogboe and the bout was stopped as Dogboe unloaded a big flurry on to the Japanese fighter.
This is likely to be Otake's final bout as a professional, and we're expecting him to announce his retirement very soon. As for Dogboe the future is very exciting and he openly called out the other world champions after his win, with potential show downs against Rey Vargas, Daniel Roman and TJ Doheny all interesting looking bouts for the young fighter from Ghana.
Japan's Ryosuke Iwasa (25-3, 16) [岩佐 亮佑] has a reputation of coming up short against the best Southpaw's he's faced. That proved to be the case again today when he lost the IBS Super Bantamweight title to Australian based Irishman TJ Doheny (20-0, 14) via unanimous decision at the Korakuen Hall, with the loss following previous defeats to southpaws Shinsuke Yamanaka and Lee Haskins.
The champion, defending his belt for the second time, had a good start. Both men looked to feel the other out but it was a right by Iwasa that caught the eye as he wobbled the challenger, and left him with a nasty cut on his right cheek. It seemed an almost perfect start. He was however unable to capitalise and the following round a busier, quicker and sharper Doheny was about to out work a one paced Iwasa, who landed another good right hook but spent too much of the round stalking and not enough actually fighting.
Rounds 3 and 4 were also good ones for Doheny who out landed Iwasa and landed some really eye catching head shots. Although Iwasa again had moments he refused to move through the gears, and the good shots he was landing were rarely followed up on, whilst Doheny actually let his hands fly in bursts. By the end of round 4 the challenger wasn't just cut but also swollen under the left eye, but showed little worry of Iwasa's power, often circling with his hands down.
Iwasa managed to have more success in round 5, when he began to feint less and through more. Doheny seemed to feel the power more often, and it certainly seemed like Iwasa had more power than the supposedly heavy handed Doheny, but it against seemed like Iwasa was too concerned on single shots and not his combinations. The Japanese fighter has a really potent straight left hand, but he did little to set the shot up, and seemed to be willing to look for perfect shots as opposed to taking a risk or two.
Round 6 was a stand out round as the two men went tit for tat. Doheny had the early success, and and had a big attack about a minute into the round. Iwasa fired back, and seemed to rock Doheny at one point before fighting back. It again seemed to show that Iwasa was the puncher in the fight and that Doheny's reputation as the puncher wasn't right, but it was Doheny who always seemed to engage the attacks and force the fight. In fact round 7 was another good one for Doheny, who landed a brilliant combination late in the round. The challenger was spoiling up close, but but knew what he had to do to get shots off and to smother Iwasa.
Iwasa had a better round in round 8, as the two both let their shots go with more freedom than they had earlier on. It was clear that neither man was too confident that they were in the lead, but it was Iwasa who was beginning to land more, letting his shots go in bunches and landing some crunching body shots with Doheny's blood from the cut began to drip down his face. The good round from Iwasa was again neutralised by Doheny having a good bounce back round, as he once again out worked the Japanese fighter.
Round 10 was one of the most competitive rounds of the fight. Doheny started really well, but Iwasa managed to come on strong, landing a fantastic right hand late in the round before a body shot seemed to hurt the challenger. The success there was finally built one by Iwasa who had an amazing round 11, his best round, as he finally moved through the gears, let his shots go and hurt Doheny, who looked to be running on fumes. The body shots looked like they had knocked the gas out of Doheny who clinched, spoiled and even wrestled Iwasa to the floor as he tried to see out the storm.
It looked like Doheny was going to be there for the taking in round 12, but amazingly he had his second wind, just when he needed it, and he out worked Iwasa through the round. Iwasa, did little when he really needed to let it all go.
Sadly for the Japanese fighter his failure to fight fire with fire in round 12, among other rounds, was the difference between the two men and Doheny was a worth decision winner, with the judges scoring the bout 117-112, 116-112 and 115-113 in favour of Doheny.
Sadly those watching on ESPN+ in the US had a narrative from Teddy Atlas of a robbery, it wasn't. The right guy win, though 117-112 is wide of the mark the other two scores are spot on, with the best Iwasa could have hoped for was a draw. He let Dohney have his way too much, and the destructive Iwasa who claimed the title in eye catching fashion against Yukinori Oguni was nowhere to be seen here.
Last year we saw the IBF Super Bantamweight end up in the hands of Ryosuke Iwasa (25-2, 16) [岩佐 亮佑], following his sensational performance against Yukinori Oguni. Today he made his first defense of the title, taking on little known Filipino challenger Ernesto Saulong (21-3-1, 8), and taking a wide decision over the gutsy visitor.
Sadly for Iwasa the performance was far from the quality that he showed against Oguni, and was more of a disappointing outing, despite retaining his title with relative ease.
The bout started with Iwasa seemingly fighting well within himself, he was controlling the distance and tempo of the bout at range, finding a home for his powerful left hand and looking very relaxed. A little bit too relaxed at times and it seemed like he really should have been looking to move through the gears, the fans something to remember and continue to show what he can do in the ring.
After 3 rounds Iwasa looked in total control, though Saulong did manage to have some moments in round 4, as he began to utilise a tactic that Richard Pumicpic had also used against Iwasa. That was to cut the distance, swarm Iwasa and force him to fight up close, something Iwasa doesn't ever look comfortable doing. It was however a tactic that Saulong didn't manage to have much consistency with an Iwasa resumed total control the following round.
It wasn't until round 9 that you could make any sort of a case for Saulong to have won another round, as he upped the pace, showed a real lack of respect to Iwasa at last and applied the pressure. The challenger built on that success in the following round and had his best round as he seemed to feel some new found confidence. That confidence was however crushed in round 11 as Saulong was staggered, hurt and rocked back into his shell with Iwasa coming close to scoring a knockdown. It was the only real time that Saulong was hurt and the only time that Iwasa ever looked like he was hunting a stoppage.
To his credit Saulong saw out the storm and came back at Iwasa in the final round, but took some big shots to end the bout with Iwasa never looking in trouble.
It was gutsy effort at times from the challenger, but he really wasn't competitive, and that was reflective on the score cards which read 120-108, 119-109 and 118-110 for Iwasa. The champion retained his title, but lost some of his shine with was a very forgettable win for the hard hitting southpaw,
Last year we saw Daniel Roman (24-2-1, 9) claim the WBA Super Bantamweight title with a stoppage win over the previously unbeaten Shun Kubo in Kyoto. Today he returned to Japan to defend his title against the touted Ryo Matsumoto (21-2, 19) [松本亮], who was stepping up for his first world title bout.
The fight started pretty competitively, with Roman bringing the pressure and Matsumoto needing to respond to it. The Japanese fighter landed some good body shots, but seemed to be out worked, out landed and in same ways out though by Roman, who used a good solid jab and clever footwork to cut the distance against the taller man. The success of Roman continued through the fight, with a lot of close rounds, but a lot of rounds where he simply did a bit more than Matsumoto, who looked to land single shots, namely the jab up top and the left hand to the body. Roman however had more variation to his work, the jab, the right hand over the top, and the body shots.
Although Roman seemed to be doing the better work, there was a lot of competitive action and Matsumoto did more than hold his own in a number of rounds, including round 3, which was one of his best rounds. The problem for him is that Roman really didn't seem to feel his power, and kept coming forward, even the big shots of Matsumoto seemed to be taken with ease from Roman.
In the middle rounds we saw some great trading sequences, as Matsumoto started to hold his ground more, and even when he was backed up he was letting his hands go a bit more often, as he did from the ropes in round 7. Though by being backed up so frequently he was making life a little bit too easy for the judges, who were always going to favour the aggression of the champion over the challenger's shots on the retreat.
In round 8 Matsumoto had another of his stronger rounds, landing some big body shots, though Roman continued to take them well. The champion did seem to feel them more than once, but only needed a second or two before returning fire and putting Matsumoto under pressure again, likely stealing the round with a late assault.
Matsumoto even tried to change his tactics late on, pressing Roman backwards, and whilst he had success at times he couldn't keep it up for long, with Roman turning the pressure around and forcing Matsumoto backwards. It was keeping the fight competitive on a round by round basis, but with Roman always just doing a touch more when he came forward, and seemingly always looking like the man who knew when, and how, to step up the pace. This certainly seemed to be the case in rounds 9, 10 and 11, with Matsumoto looking like he was having good rounds until Roman turned the pressure up and fought back.
The final round was one where Roman really stepped back on the gas from the off. It was as if he was thinking "if all the close rounds go to the challenger, I really might need to make a statement here". He went out hunting a KO and forced a real fight, with both men taking some huge shots ina thrilling back and forth round, despite being back and forth it was clear that Roman was getting a lot more to land than Matsumoto, who had to reset more often, and backed off during key exchanges.
In there end there was no doubting the winner, and that was shown on the scores cards which read 119-109, twice and 118-108. The fight could have been scored closer, and Matsumoto certainly didn't disgrace himself, but he was the clear loser. Sadly though the score cards make the bout look like a near whitewash, which doesn't reflect the competitiveness of the bout, despite being pretty cards.
(Image courtesy of Daily.co.jp)
Earlier today fight fans had the chance to tune into an IBF Super Bantamweight title fight as defending champion Yukinori Oguni (19-2-1, 7) [小國 以載] took on mandatory challenger Ryosuke Iwasa (24-2, 16) [岩佐 亮佑], in what looked like a 50-50 match up on paper.
The fight had had some very friendly build up between two men who have known each other for years and had a genuine laugh in the various pre-fight events. In fact that fun seemed to run all the way to the first bell.
When the bell rang it was Oguni who was fast out of the traps, using his speed, movement and boxing to get off to a hot start. Iwasa seemed slightly surprised but covered up, waited out the early storm and started to fight back, almost instantly finding a home for his thunderous left hand. Towards the end of the round one of those left hands did their job and dropped Oguni, securing a 10-8 round for the challenger, who was probably just losing the round prior to the knockdown.
Round 2 saw Oguni regroup brilliantly and take the early moments, using his speed and more fluid natural boxing ability. Sadly though for Oguni he against had no answer for Iwasa's left hand, and brutal power, being dropped hard late in the round. Oguni's fighting heart helped him got back up and resume, but he was drown again soon afterwards, and facial damage was beginning to show on the champion.
In round 3 it was Iwasa starting faster, and looking to go for a finish as he landed a number of folid left hands on the champion. Oguni to his credit gritted his teeth and had moments, but those moments were all sniffed out when Iwasa threw, with almost every left hand on target actually landing on the challenger. The one respite for Oguni was that the referee was on Iwasa's case for pushing on his head, and actually took a point in round 4 for it.
Not only did Oguni get the "advantage" of his opponent losing a point but he also seemed to become rejuvenated in the 4th as he took the fight to Iwasa in a thrilling back and forth that saw Oguni being hurt several times but unloading on Iwasa and having one of his best rounds. Oguni's power never seemed to trouble Iwasa, but his work rate and aggression through the round gave Iwasa issues, and it was a very close rounds, potentially a 10-8 for Oguni or a 9-9.
Another close round followed as Oguni seemed to begin to feel the momentum shift in his favour. Sadly that momentum was snuffed out later in the round as Iwasa landed a series of big left hands that arguably stole the round for the challenger.
Having snuffed out the momentum of Oguni's at the end of 5 Iwasa went for the finish early in round 6 and really left his shots go early on. Oguni was rocked several times and his face had started to become a crimson mask. The shots of Iwasa's were leaving his gloves painted with Oguni's blood and it looked like a stoppage was imminent. Oguni however, had other thoughts and began to take the fight to Iwasa, cornering Iwasa and unloading.
Following Oguni's success the referee finally seemed to notice Oguni's face, and took him over to the ringside doctor who wave the bout off after a quick inspection. During the inspection Oguni seemed to have some sort of facial fracture, a badly cut lip and serious damage around his eye. Almost forcing the doctors hand.
For Iwasa the win sees him finally fulfilling his potential and claiming a world title in his second shot. Potentially this lines him up as a potential target for good friend Shingo Wake, young sensation Hinata Maruta, former title challenger Hidenori Otake or former champion Tomoki Kameda. As for Oguni it's time to spend a few weeks resting and recovering as that sort of facial damage will need some serious time away from the ring.
After a great start to 2017 for Japanese boxing it seems like the seams are slowly coming apart with a number of high profile losses all coming one after the other in recent weeks, with losses for Shinsuke Yamanaka, to Luis Nery, Yoshihiro Kamegai, to Miguel Cotto, and today we saw Shun Kubo (12-1, 9) [久保隼] suffer his own high profile loss, and lose the WBA Super Bantamweight title in his first defense.
The Shinsei Gym fighter won the title earlier this year, beating veteran Nehormar Cermeno, and immediately planned for today's defense against American Daniel Roman (23-2-1, 9). That planning didn't really seem to help today against a fighter who seemed so much more determined and hungry than Kubo, and looked like a fighter who was much more naturally composed and relaxed in the ring, even under fire.
The first round was a feeling out round, and it saw Kubo getting the upperhand as he used his reach and southpaw stance to control the distance and range behind his jab and stiff left hand. It was a round for the champion in terms of the scorecards, but gave the challenger a lot of details on how Kubo handled pressure, and what his power was like. In the second round Roman began to get more aggressive with his scouting, and apply more pressure. He was forced to eat some very solid left hands as a result, but never looked phased by them, as his engine moved up a gear.
Round 3 and 4 both saw Roman begin to take over the fight. He was a lot less passive with his pressure than he had been and really fired off up close. Kubo did respond at times, and landed some eye catching shots to head and body, but could never discourage Roman and instead it was Kubo who looked to be the one backing off from an exchange. Whilst it was clear Kubo wanted range he never managed to back off and establish it, instead he backed off, and was quickly walked down, again and again. It wasn't until round 5 that Roman showed any signs of slowing, but that was a round where chinks in Kubo became even more glaring, as even when he looked settled he couldn't ever gather his composure in the way Roman did.
The pressure seemed to wane in round 6 until towards the end of the round when Roman clearly hurt Kubo, rocking him hard before the bell seemed to save the now deflated champion. Kubo's body language at the end of the round seemed to be that of a beaten man. Despite looking mentally beaten he went out for round 7, and that was something special with Roman jumping on Kubo almost instantly and going to work on the champion, Kubo looked helpless before being dropped and in other countries that could have been the end. Roman then unloaded as Kubo tried to fire back, with the referee getting several chances to stop the contest. Amazingly after several waves of punishment from Roman Kubo looked alive, and started firing back, with bad intent, drawing loud applause from the crowd, who seemed to be won over by the local man's heart and desire.
Round 8 again saw the crowd getting behind their man, as they tried to re-energise him and help him build some momentum. He tried hard to get things going but in the end Roman's pressure told and just before the bell he was down again.
Now clearly ahead on the cards Roman could afford to take his foot off the gas, but chose not to, instead hunting the stoppage. That stoppage would come following a prolonged assault on Kubo who was out on his feet and unable to fire back, completely worn down and broken up by the pressure.
With the 9th round TKO win under his belt Roman stayed in the ring and gave an interview for the fans, who showed their respect to the new champion, who himself came across as a classy, smart and talented fighter, giving Kubo and the local fans credit. Given the performance he will almost certainly be invited back to Japan to face some of the other Japanese fighters at Super Bantamweight, potentially Tomoki Kameda, Hinata Maruta or Yusaku Kuga. If he wants to fight in the US and defend his title at home we hope fans tune in as he's a really exciting and personable fighter as he showed in this win today, his biggest win so far.
For Kubo it's back to the drawing board. At 27 he has time to bounce back, but needs to really work on his composure in the ring and keeping his confidence, which has been questioned in the past. He's a skilled fighter, but does seem to lack the mental belief and and doesn't have the defense or the power to reclaim a title unless he seriously tweaks his styles. Saying that his fight back in rounds 7 and 8 were great, and for that he deserves serious credit, there is a real gutsy fighter there, but one who perhaps needs more time to develop than he was given, as Shinsei seeked an immediate replacement at the top of their stable for Hozumi Hasegawa.
World Title Results
Whether you like them or not World Titles add prestige to any bout as a result we've included the results of world title bouts in this special section.
November 2019


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You can now play Christmas Piano Tiles for PC on a desktop/laptop running Windows XP, Windows 7, Windows 8, Windows 8.1, Windows 10 and MacOS/OS X. This can easily be done with the help of BlueStacks or Andy OS Android emulator.
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Contact Us: We love to hear genuine suggestions and comments, kindly rate your playing feel in words here on the store and for more information on updates, reach us at
There is a new Piano Tiles game in town and it is now the Holiday edition version featuring a beautiful Christmas song's key notes. Quit playing that boring ol' black and white tiles and play with some gorgeous red tiles to get into the holiday spirit.
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How to download and run Christmas Piano Tiles on your PC and Mac
Christmas Piano Tiles For PC can be easily installed and used on a desktop computer or laptop running Windows XP, Windows 7, Windows 8, Windows 8.1, Windows 10 and a Macbook, iMac running Mac OS X. This will be done using an Android emulator. To install Christmas Piano Tiles For PC, we will use BlueStacks app player. The method listed below is set to help you get Christmas Piano Tiles For PC. Go ahead and get it done now.
More Details
Download Links For Christmas Piano Tiles:
Download: Bluestacks Android Emulator
Download: Christmas Piano Tiles (Play Store)
More From Us: Angry Gran Run – Running Game For PC / Windows 7/8/10 / Mac – Free Download
Step to Step Guide / Christmas Piano Tiles For PC:
- As you have Downloaded and Installed Bluestacks Emulator, from Links which are provided above.
- Now, After the installation, configure it and add your Google account.
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Also Read: Sweep Clean For PC / Windows 7/8/10 / Mac – Free Download
That would be all from our side. In case you have got any queries or you have any issue following the guide, do let me know by leaving your thoughts in the comments section below.


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It's been a long day, and all you can think about is getting in bed with your wife so both of you can unwind the adult way. Heck, you've even been sexting her while at work to try to spice things up so that she'll look forward to it more. But when it's finally time to start, you can't help but feel distracted even when you're having sex in your favourite position. Why is that?
It could be a lack of mindfulness.
A recent article in The Guardian explores how the problem stems from being too worried about what's going on elsewhere in your life and being too stressed out to truly enjoy sex.
"People are worried about their jobs, worried about money. They are not in the mood for sex," said Cath Mercer from University College London. "But we also think modern technologies are behind the trend, too. People have tablets and smartphones and they are taking them into the bedroom, using Twitter and Facebook, answering emails."
So what is mindfulness exactly? According to Lori Brotto, a professor of psychology at the University of British Columbia and the executive director of the Women's Health Research Institute in Canada, mindfulness is a "present-moment nonjudgmental awareness. Each of those three components are critical for healthy sexual function"
Simply put, when you're having sex, stop worrying about everything else and focus on your partner, yourself, and your desire for each other.
Psychosexual and couples therapist, Kate Moyle, states that mindfulness has been used before in therapy. "When people have sexual problems, a lot of the time it's anxiety-related and they're not really in their bodies, or in the moment. Mindfulness brings them back into the moment.
"When people say they've had the best sex and you ask them what they were thinking about, they can't tell you, because they weren't thinking about anything, they were just enjoying the moment. That's mindfulness." Moyle says the techniques involve "encouraging people to focus on their sensations, explore their senses, hone in on what is happening in their body and how they're experiencing it".
Ammanda Major, the head of clinical practice at the relationship support organisation Relate, says mindful sex "is about focusing in the moment on what's going on for you and making sure all the extraneous things get left behind. For example, if you're being touched by your partner, it's really focusing on those sensations. People may find themselves very distracted during sex, so this is a way of bringing themselves into their body and being totally aware of themselves in that moment."
It may sound like a lot more work just for some sex. After all, if you and your wife are tired after work, putting in more effort to concentrate won't really change things will it? The good news is that you don't really need a drastic change in the way you have sex for mindful sex to work.
"You might have sex the same way, in the same position, but you're in a different headspace, so you're experiencing it differently," says Moyle. "People can think: 'I'm not into mindfulness,' or: 'It's a bit spiritual and I'm not,' but it doesn't have to be that. It can just be really straightforward – focusing your attention and fully experiencing sensations."
So the next time you're about to get frisky in bed, just remember to be in the moment. If mindfulness therapy can be used for depression, perhaps using it for a better sex life may not be so farfetched after all.
By Gilbert Wong, Men's Health Content Producer
Getting An Orgasm Without Physical Stimulation? Here's How It Can Happen


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Lord let us not be weary in well doing.
Let your grace and mercy be our companions.
May we be bright lights shining in dark places.
Keep our focus on you that we don't look to the left or the right.
Renew our joy and refill us with your Spirit daily.
Deliver the captives. Set souls free from bondage.
We are thankful for all your blessings.
Thy will be done.
In your name we pray
ETS MinistriesReturn to the Im Not The Same Woman I Used To Be Im Free Show Page
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MADISON, N.J. - Six different Rangers scored in double figures and the Drew University men's basketball team pulled away late to beat cross-town rival FDU-Florham 86-72 in a non-conference tilt Tuesday evening in Baldwin Gym.
The Rangers (4-1) broke the game open with a 15-2 run that turned a tie game into a 76-63 lead following a 3-pointer from junior guard Miles Lewis with 5:15 remaining. The Devils (3-4) were unable to get closer than 10 the rest of the way.
Junior forward Lybrant Robinson led Drew with 22 points and eight rebounds while freshman forward Howard McBurnie, Jr. registered 15 points on 7-of-9 shooting to go with six rebounds. Four Rangers scored 10 points, including junior forward Malachi Walker, Jr., who also grabbed 12 rebounds for his third double-double of the season. Senior guard Michael Boice added 10 points and eight rebounds while classmate Riley Collins contributed 10 points and six assists. Lewis also netted 10 points.
Oliver Ortman led all players with 26 points on 6-of-11 3-point shooting for FDU-Florham while Shawn Smith finished with 23 points, nine rebounds, and six assists.
It was a back-and-forth affair in the early going, when there were three ties and eight lead changes over the opening 10:28. Neither side led by more than five until a 10-2 Ranger run opened up a 10-point lead. Five different players scoring during the spurt, and a put-back from Robinson made it 41-31 with 3:36 on the first-half clock. The Devils edged to within 45-39 at the break.
Drew shot 58.6% from the floor in the first half and out-rebounded the Devils 24-13.
The Rangers pushed their lead to nine with 13:21 remaining following a Boice 3-pointer, but that's when the Devils answered with a 7-0 surge to cut the gap to 59-57. The visitors came all the way back to tie the game at 61-all with 9:36 to go on a lay-up from Derrick Whitaker. However, the Rangers immediately answered on a jumper in the paint from Walker, kicking off the team's decisive 15-2 run. Robinson and McBurnie each knocked down a triple during the outburst before Lewis also connected from downtown.
Drew squashed any threat of an FDU comeback with a pair of big put-backs down the stretch, getting buckets from McBurnie with 2:31 to go and Robinson with 53 seconds left. Each basket handed the Rangers a 12-point lead.
The Rangers shot 51.6% for the game and finished with a 47-30 rebounding advantage
The Blue and Green pick up their schedule on Wednesday, Dec. 4, when they conclude their six-game homestand to open the season by taking on King's College in a non-conference affair starting at 7 p.m.
Balanced Effort Lifts Drew Over FDU-Florham
|FDU-Florham (3-4)
|Drew (4-1)
MADISON, N.J. - Six different Rangers scored in double figures and the Drew University men's basketball team pulled away late to beat cross-town rival FDU-Florham 86-72 in a non-conference tilt Tuesday evening in Baldwin Gym.


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Best fucking bar in the Tenderloin! I loved every second I spent here. I remember it was pretty small and crowded, but the bartender was pretty... (more)Rated
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Thursday, November 16, 2017
(CAR) T Chimeric Antigen Receptor T Cell Based Gene Therapy
After the approval of Kymriah in August 2017, with a price tag estimated to be $475,000, followed by Yescarta at $373,000, and more in the pipeline, it is now time to better understand Chimeric Antigen Receptor T cell therapy (CAR) T cell infusion therapy. This type of cancer therapy will replace the current high cost Specialty Drugs as a new industry of high pharmaceutical costs for payers.
Chimeric Antigen Receptor T cell therapy or (CAR) T is a type of treatment in which patient's T cells, a type of immune cell, are taken from a patient's own blood, and then genetically engineered to produce CAR-producing T cells. In the laboratory a gene for a special receptor, Chimeric Antigen Receptor, is inserted into the patient's T Cells so that they will bind to a certain protein on the patient's cancer cells. After millions of (CAR) T cells are grown in the laboratory, they are then infused into the patient's body, where they further multiply and attack cancer cells.
On August 30th, 2017, the FDA approved Kymriah (tisagenlecleucal), the first (CAR) T cell therapy drug manufactured by Novartis. Kymriah is indicated for the treatment of patients up to 25 years of age with B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory or in second or later relapse. It will be supplied through two (2) specialty distributors, and then shipped to one of only 32 treatment centers in the US that can administer this drug.
"The price for a single infusion of Kymriah does not include pre-infusion treatment costs, drug administration and hospitalization costs. When those costs are added, the average total cost….is estimated to be up to $750,000."
The second cell-based gene therapy, Yescarta (axicabtagene ciloleucel), was approved by the FDA on October 18th, 2017 and is manufactured by Kite Pharma, which was recently bought by Gilead, the makers of the Hepatitis C blockbuster, Harvoni. Yescarta will be used to treat certain types of Lymphoma, including Diffuse Large B-Cell Lymphoma (DLBCL), that have not responded to at least 2 prior therapies.
Each dose of Yescarta is a customized treatment created using a patient's own immune system to help fight the lymphoma. The complete remission rate after treatment was 51 percent; however, treatment with Yescarta has the potential to cause severe side effects, including 3 reported deaths. The FDA is requiring that hospitals and their associated clinics be specially certified to dispense this drug. There are currently only 16 treatment certified centers, including Dana Farber and Sloan Kettering.
Diffuse large B-cell lymphoma (DLBCL) is the most common type of NHL (Non-Hodgkin's Lymphoma) in adults. NHLs are cancers that begin in certain cells of the immune system and can be either fast-growing (aggressive) or slow-growing. Approximately 72,000 new cases of NHL are diagnosed in the U.S. each year.
There are 20 similar drugs currently in development by various pharmaceutical manufacturers. Novartis is studying CTL119, for multiple B-Cell malignancies, as well as therapies for leukemia, multiple myeloma, and solid tumors. Juno Therapeutics is developing several more, for multiple myeloma, and pediatric leukemia.
In just several decades, gene therapy has gone from being a promising concept to a practical solution to deadly and largely untreatable forms of cancer," said FDA Commissioner Scott Gottlieb, M.D.
PBIRx has been exclusively providing intelligent solutions to clients in the management of pharmacy benefit costs since 1993. With a staff that includes IT personnel, actuaries, financial analysts, clinical pharmacists, attorneys, HIPAA Compliance Officers and many more experts, PBIRx's mission is to create optimal health care outcomes while minimizing overall health care costs. For more information, please visit www.pbirx.com or call (888) 797-2479.
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2 December 2019
Our Data team is unique, and is the driving force behind the work that we do. Combining exclusive data partnerships and skills across a variety of tools and platforms, our team is a place where brilliant minds come together to make bold, award-winning ideas come to life. We use data-driven insights to guide our work, but we also believe in a healthy dose of spirited storytelling as we strive to transform the marketing landscape.
To help with this, we're looking for an outstanding Analyst to drive that transformation with our Media team – someone with a background in both strategy and analytics with an understanding of how the two work together. Sounds like you? Read on…
We have 40 offices in 25 countries, each one helping to upend and redefine the landscape of strategy, creativity, media and technology. We're pumped about the accolades we've earned – cue Titanium Lions, Gold Pencils and making LinkedIn's Most InDemand Employer List of 2014 – but what energizes us most is the people we work with, the clients we work for and the never-ending challenge that confronts us: Producing amazing creative, day after day. On top of great values, great people and great clients, we're proud to offer many great perks – things like flex vacation days, tuition reimbursement, gym membership discounts and anniversary gifts for the many people who've been with us 5, 10, 20 years and more. And while we celebrate those who've stuck by us and shaped us into the creative force that we are today, we're always looking for great new talent help us grow even stronger. If that's you, well, come join us.
Digitas is an equal opportunity employer.


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Temporary excavations during the construction of the Glendoe Hydro Scheme above Loch Ness in the Highlands of Scotland exposed a clay-rich fault gouge in Dalradian Supergroup psammite. The gouge coincides with the mapped trace of the subvertical Sronlairig Fault, a feature related in part to the Great Glen and Ericht–Laidon faults, which had been interpreted to result from brittle deformation during the Caledonian orogeny (c. 420–390 Ma). Exposure of this mica-rich gouge represented an exceptional opportunity to constrain the timing of the gouge-producing movement on the Sronlairig Fault using isotopic analysis to date the growth of authigenic (essentially synkinematic) clay mineralization. A series of fine-size separates was isolated prior to K–Ar analysis. Novel, capillary-encapsulated X-ray diffraction analysis was employed to ensure nearly perfect, random orientation and to facilitate the identification and quantification of mica polytypes. Coarser size fractions are composed of greater proportions of the 2M1 illite polytype. Finer size fractions show increasing proportions of the 1M illite polytype, with no evidence of 2M1 illite in the finest fractions. A series of Illite Age Analysis plots produced excellent R2 values with calculated mean ages of 296 ± 7 Ma (Late Carboniferous–Early Permian) for the oldest (2M1) illite and 145 ± 7 Ma (Late Jurassic–Early Cretaceous) for the youngest (1M) illite. The Late Carboniferous–Early Permian (Faulting event 1) age may represent resetting of earlier-formed micas or authigenesis during dextral displacement of the Great Glen Fault Zone (GGFZ). Contemporaneous WNW(NW)–ESE(SE) extension was important for basin development and hydrocarbon migration in the Pentland Firth and Moray Firth regions. The Late Jurassic–Early Cretaceous (Faulting event 2) age corresponds with Moray Firth Basin development and indicates that the GGFZ and related structures may have acted to partition the active extension in the Moray Firth region from relative inactivity in the Pentland Firth area at this time. These new age dates demonstrate the long-lived geological activity on the GGFZ, particularly so in post-Caledonian times where other isotopic evidence for younger tectonic overprints is lacking.
Geochemical and related studies have been made of near-surface sediments from the River Clyde estuary and adjoining areas, extending from Glasgow to the N, and W as far as the Holy Loch on the W coast of Scotland, UK. Multibeam echosounder, sidescan sonar and shallow seismic data, taken with core information, indicate that a shallow layer of modern sediment, often less than a metre thick, rests on earlier glacial and post-glacial sediments. The offshore Quaternary history can be aligned with onshore sequences, with the recognition of buried drumlins, settlement of muds from quieter water, probably behind an ice dam, and later tidal delta deposits. The geochemistry of contaminants within the cores also indicates shallow contaminated sediments, often resting on pristine pre-industrial deposits at depths less than 1m. The distribution of different contaminants with depth in the sediment, such as Pb (and Pb isotopes), organics and radionuclides, allow chronologies of contamination from different sources to be suggested. Dating was also attempted using microfossils, radiocarbon and 210Pb, but with limited success. Some of the spatial distribution of contaminants in the surface sediments can be related to grain-size variations. Contaminants are highest, both in absolute terms and in enrichment relative to the natural background, in the urban and inner estuary and in the Holy Loch, reflecting the concentration of industrial activity.
Parent–child relationships have long-term effects on health, particularly later inflammation and depression. We hypothesized that these effects would be mediated by later romantic partner relationships and elevated stressors in young adulthood, helping promote chronic, low grade, inflammation as well as depressive symptoms, and driving their covariation. It has been proposed recently that youth experiencing harsher parenting may also develop a stronger association between inflammation and depressive symptoms in adulthood and altered effects of stressors on outcomes. In the current investigation, we test these ideas using an 18-year longitudinal study of N = 413 African American youth that provides assessment of the parent–child relationship (at age 10), pro-inflammatory cytokine profile and depressive symptoms (at age 28), and potential mediators in early young adulthood (assessed at ages 21 and 24). As predicted, the effect of harsher parent–child relationships (age 10) on pro-inflammatory state and increased depressive symptoms at age 28 were fully mediated through young adult stress and romantic partner relationships. In addition, beyond these mediated effects, parent–child relationships at age 10 moderated the concurrent association between inflammation and depressive symptoms, as well as the prospective association between romantic partner relationships and inflammation, and resulted in substantially different patterns of indirect effects from young adult mediators to outcomes. The results support theorizing that the association of depression and inflammation in young adulthood is conditional on earlier parenting, and suggest incorporating this perspective into models predicting long-term health outcomes.
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text: Since we are down to just 3 or 4 tokens left and since this whole project has been such a huge success, so you thing MS will do another? Someone told me that he was planning a global hunt, which is cool, but I would like to see another one here in the states. It may be hard though for him to come up with a totally new type of puzzle. As we have seen, once you have figured out the trick to all of this, you can solve almost any puzzle. I think if he did another, he would have to come up with many different types of solutions. I am sure he has made enough money off of this prioject to fund another (not to mention he is wealthy already). Now that he has us all hooked and looking at pictures in everyday magazines wondering if there is a hidden message (hehehhehe), he can't leave us high and dry. Anyone know what is in the works?


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Ravshan Irmatov announces his retirement from refereeing
The Asian Football Confederation (AFC) on Tuesday celebrated the achievements of its leading match officials at the start of the biggest-ever AFC Refereeing Conference which was held in Kuala Lumpur, Malaysia.
The opening ceremony honoured eight referees and assistant referees who were presented the AFC Referees Memento Award. The officials were recognised for their outstanding service in raising the refereeing standards in Asia.
Three-time FIFA World Cup referee, Ravshan Irmatov from Uzbekistan was joined by Australia's Peter Daniel Green and Nagor Amir bin Noor Mohamed from Malaysia in receiving the award in the Referees category.
Five-time Asian referee of the year, Ravshan Irmatov announced his retirement from refereeing in the conference.
Фикр қолдириш учун авторизациядан ўтинг!


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Captain Curtis Mansfield
Captain Curtis Mansfield started his career with the Tennessee Highway Patrol in Decatur County as a road Trooper in 1988. In 1993 he was promoted to Sergeant in Madison County. He was promoted to Safety Education Lieutenant in Madison County in 1999 and then served as the Administrative Lieutenant. Mansfield held this position for eight years before being promoted to Captain in 2010.
Captain Mansfield attended the Federal Bureau of Investigation Academy in 2011.