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Job Details
Career Smart - Our client, a Management Consulting firm with operations across Nigeria, invites applications from suitably qualified candidates to fill the position below :
Job Requirements
Min Required Experience :
Min Qualification :
Bachelor's Degree / HND
Desired Courses : Not Specified
Other Requirements : Applicant Must :
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You searched for: Start Over universalist Remove constraint universalist Title Motion Picture News Remove constraint Title: Motion Picture News Date 1923 Remove constraint Date: 1923
1 to 1 of 1
Search Results
1. Motion Picture News Jan-Feb 1923
... . Stevens has succeeded James Savage as manager of the Central Park theatre, controlled by General Theatres Corporation. Members of the Universalist Church organization in Middleport, N. Y., have started a Children's theatre movement in the town, showing motion pictures especially for the kiddies every Saturday aft- Jay Berman is suing Joseph A ...

subset: commoncrawl


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In this clip we're going to actually show
you some wrist and forearm movements here to help stretch out in through the carpal
tunnel area. This stool is actually going to represent your desk, so, here again you
can do these at your desk. Your hands are actually going to be right on the desk. Bring
your fists together so that your hands are, actually your fingers are towards each other
here. You're just going to bring your arms out towards the side and back in. So stretching
and making circular movements here with your wrists. You're going to keep your hands right
in line with each other, and actually your forearms right in line with each other, and
just moving your hands back and forth. Then just do that a few times and then releasing
bringing your arms up parallel to the floor. And do the same thing here. You're just going
to raise your hands, keeping them in a fist, and then extending out through your forearms.
So here you'll feel this on the bottom side of your forearm and then the upper side of
your forearm. Just going back and forth a couple of times, and then extending your arms
out. You can come back down towards your desk here. Then just pressing into your hands slightly.
Do a little bit more stretch, and release, shaking everything out. Shaking everything
out is very important, so that you can release any tension that has happened here by actually
causing through that stretch process.


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STEP 1: Smile Design & Treatment Planning
Every 3 Step Smiles Treatment begins with a Smile Design process in which our Expert Team will work with our Patient to Design the Ideal Smile for them, based on their facial features, personality and desires. And the Treatment won't start until they totally love it!
Once the Smile Design is approved, our Team will define the best Treatment Plan to achieve that Ideal Smile, using a combination of the most advanced Implantology, Orthodontics and Aesthetic Dentistry Techniques and Technology. You will have the opportunity to see, and even feel, your new Smile even before starting the Treatment!
STEP 2: Treatment Execution
Once approved, our Team of Dentists will work on the planned Treatment using the most advanced Technology and Techniques to make sure that the best Functional and Aesthetic Results are achieved using the least invasive procedure possible.
All our Treatments are Digitally Planned, to make them Safer and more Accurate. They are executed with the help of Technology and all the applianced and devices it provides us with, allowing us to reproduce the Ideal Smile with amazing accuracy. Once the Treatment is executed you will be ready to receive your Final Smile, which will be a beautiful and natural reproduction of your Smile Design process.
STEP 3: The Final Smile
Thanks to our Fully Digital designing, planning and production process, we can recreate the Ideal Smile with perfect accuracy, and make it Real.
The final Smile will always look the same as the Smile Design project that you previously approved. Satisfaction is guaranteed!


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No matter what business you're in, you can put the Internet to use for you and use it to help you build your business and rake in more sales.
The statistics on how many people are online now are mind-blowing.
As of November of last year, there are over One Billion people online.
This gives all of us an incredible opportunity to grow our businesses, to global proportions, if that's what we want.
However, the Internet is not without pitfalls and obstacles.
In fact, if you make the wrong move you can find yourself in very real danger of losing everything you've worked so hard to build.
Things to keep in mind when using the Internet to market your business:
- Create a Professional Looking Website
These days with all the readily available Website templates, blogs and highly affordable Website designers who can be hired to design a custom Website, there just isn't any excuse for amateurish or poorly built Websites.
Even when you add the cost of Internet access, hosting, buying the right domain name and the cost of having a Website built, starting an online business is affordable to almost anyone and so even if you run your business from your home, it doesn't have to look that way!
- Do your Research
Find a hungry market that is already buying, in your chosen niche.
Choose a product that your target market wants to buy – the best way to do this is to choose a product or service that meets a need, takes away a pain or solves a problem. Competition is good – but make sure you choose something where you've got a good chance of getting close to the top.
- Write a Business Plan
Even if your business is completely online, a business plan is your road map that helps guide you from where you are right now to where you want to end up.
Business plans aren't just for people who are looking for venture capital or business loans. Include your plans for marketing and selling on the Internet in your plan. Be flexible and willing to adjust those plans as needed.
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Do you know where you want to end up? What are you going into business for? To make a little extra money? To build a business that you can later sell and live on the proceeds?
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Although some people call them hokey or old fashioned, having a vision for your business can help you to stay focused and moving towards what you want.
Whether you believe in them or not, a vision board can keep you excited and motivated.
If you do a Google Search, you'll find several companies that let you build a vision board online – and will even let you send it to your team, your mentors or other people who matter to you.
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Once you know your long-term plan for your business, it's easier to chunk it down and create shorter, medium and long term goals that will help you to achieve them.
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- Surround yourself with Positive Supportive People
You want supportive people who will hold you accountable when you need it, give you encouragement and keep you on your toes and stretching beyond where you think you can go.
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- Test, test, test
Whatever you're doing – whether it's banner advertising, using a newsletter, trying an AdWords campaign – or any other form of Internet marketing or advertising – keep testing your results.
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- Spend your time where it's going to do the most good – making money
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Design - Working from your concept, our design staff develops your collateral marketing materials, annual reports, catalogues, publications, logos and corporate stationary online ordering packages. We can also assist in electronic design for websites, HTML email marketing, presentation graphics and multi-media production.
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Finishing - From standard binding and folding operations to intricate die cutting, foil stamping and embossing, we will work with your design team or you may call upon us for creative ideas to enhance your project.
Distribution -We provide list management, mailing services and email broadcasting to complete your marketing process. Promotional Materials - From posters and banners for advertising and trade show applications to on line branding and marketing, Hansen Printing & Design Group has the solutions.
Service - Hansen Printing specializes in one-on-one service, as if your project were the only one in our shop. Our personalized service begins with free local delivery and pick-up, proceeds through the design process, and continues as we view your project on press right through to completion and final distribution. Service is not just a word at Hansen Printing - it's how we set ourselves apart and make you a repeat customer.
If we have not talked about your company's need on this page, just ask us. WE CAN DO IT ALL.


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Plan B to Save Wolves actively participated in the rehabilitation of Sarge, a wolf dog surrendered to Apex Protection Project.
Sarge's story is not unique. Due to personal reasons including a divorce and financial issues, Sarge's family could no longer keep him nor could they afford much needed surgery to save Sarge's leg.
Sarge sustained significant injury to one of his back legs and for a couple of months was unable to place any weight on it. Because his family could not afford the medical care he needed the injury went untreated.
Additionally they had no time for him and he spent several months in a tiny enclosure without exercise, which only exasperated his injury and created a weight problem.
Apex Protection Project came to Sarge's rescue. They got him the medical treatment he needed and put him on a weight loss plan. We are pleased to report he has made a full recovery and will spend the rest of his years at their amazing sanctuary lovingly cared for.
Plan B to Save Wolves supporters' contributions helped create a happy ending to Sarge's story. We reached out to the network of supporters to help save Sarge and many answered the call. So much so $13,500 was raised specifically for his surgery, ongoing veterinarian care and rehabilitation. Donations came in from various donors including some Sedona locals. We are incredibly grateful for your support.
Want to help wolf sanctuaries and wolf dogs like Sarge? Please give us a call as we are currently taking donations to continue our mission of saving wolves and wolf dogs.


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Pantry Wood Shelving Ideas, Kitchen Storage Ideas Small
25 best ideas about small pantry on pinterest kitchen, kitchen pantry cabinet installation guide theydesignnet. 25 best ideas about small kitchen pantry on pinterest. 7 clever storage ideas for a small kitchen.
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Tag: Small Pantry Storage Ideas


text: Since 1983 the Ford Ranger model has been available in the US, it was only until 1998 that the range became known globally. It is a pick-up truck range that is currently in its third generation. The range is well equipped, with the recent generation improving the on-road drivability. After the 2016 upgrade to the series, the higher specifications mean that the vehicle can now be considered an alternative to large SUVs. Available with either a 2.2 litre TDCi diesel engine or a 3.2 litre TDCi diesel motor, both of these engines are strong with great levels of economy. In all, the Ford Ranger is a powerful range that offers efficient diesel engines and is very reliable.


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Psychologists & Psychotherapy in World
Betterhelp is a convenient, affordable, private online counseling platform available Online and via IOS & Android devices. We match you with the licensed, accredited mental health professional best suited to your individual needs in a safe and private online environment. We currently serve english speaking patients in over 200 countries. It's…
N Wolfe Rd, 440, 440, 440, 440, 440, Sunnyvale, 94085, China
Our agency was created with a single focus on helping our clients get better insight into different, specific expat markets. Our goal is to support cost-effective activity to reach specific audiences and generate new customers. We combine a data-driven approach - based on measurement and analytics - with creativity in problem-solving and…
Madrid, Spain
Assur-Travel creates and manage its own insurance programs related to international mobility. Assur-Travel is specialized in 2 segments: -The "TOURISM & TRAVEL" segment, -The "EXPATRIATION" segment. As a wholesale broker, Assur-Travel creates and manages insurance and assistance contracts distributed to a global network of brokers. In order to…
Rue Parmentier, 99, Villeneuve-d'Ascq, 59650, France
- +33 320 346 748
- Go to website
Moving to a new country? Relocate with experts. As a leading company in the sector, we can assist you for international moves in over 141 locations worldwide. Our well-trained staff will take care of packing, loading, shipping, unpacking and all the neccessary paperwork at customs. Get a free moving quote today!
International schools in World
The Deutsche Frenschule offers remote education based on the German education system. Courses for elementary school are certified by the German Government. Deutsche Frenschule offers: A German remote elementary school for German children abroad A school recommended by the ZfA (Central Agency for German Schools Abroad) Fully certified elementary…
Herbert-Flender-Straße, 6, Wetzlar, 35578, Germany
International schools in Hungary
AISB is a private and independent co-educational day school governed by a Board of Trustees elected and appointed from our parent community. The school was established in 1973 by the United States Embassy, initially to serve children of U.S. Government employees. AISB currently serves the needs of a rapidly expanding international population,…
Nagykovácsi út, 12, Nagykovácsi, 2094, Hungary
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Want to see more? Go to Directory in Hungary


text:
hey all,
i need to install version 126.96.36.199 on opensuse 11.1
in downloaded the tarbal to /tmp/firefox22.214.171.124 and untarred it,
in now have /tmp/firefox188.8.131.52/firefox and in it a whole bunch of files and folders.
i know i'm now supposed to run ./ of make or make install and i also know 'im supposed to read the readme.
here it point to Firefox web browser | Faster, more secure, & customizable
here i find no info.
i've been googeling, i found some posts saying that i need to copy firefox to /opt and run firefox &, that doesn't do much.
i also found a post saying to copy it to .user/local and run chmod -R, then run firefox &.
indeed, now it opens. but that doesn't bring it under applications.
can anybody help me to do it right?
thank you.


text:
Download klondike solitaire game 5 online game
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text:
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Bearing number : NANFL207-23
Brand : KOYO
Bore Diameter (mm) : 36,5125
d - 36,5125 mm
A0 - 53,8 mm
A - 36,5 mm
A1 - 14 mm
B1 - 51,1 mm
H - 161 mm
J - 130,2 mm
L - 90 mm
N - 13 mm
S - 18,8 mm
Bolt (G) - 7/16
A2 - 21,5 mm
Weight - 1,6 Kg
Basic dynamic load rating (C) - 3 kN
Basic static load rating (C0) - 15,4 kN
Calculation factor (f0) - 13,9
Tags : KOYO
Combined bearings consist of a radial bearing (needle roller bearing) and a thrust bearing (needle or cylindrical roller bearing). They are available in 5.000 mm -70.000 mm bore (0.1966 – 2.7559 inch). Some combined bearings are constructed similar to drawn cups, but with an added thrust bearing component.
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HCFT207-23 L3. HCFT207-23 L3 Two Bolt Flange Bearing has combination of an eccentric collar insert bearing and cast iron 2-Bolt flange housing. The bearing has a wide inner ring with an eccentric locking collar (cam lock) for attaching to the shaft. The bearing insert has two grub screws to allow tightening against the shaft once fitted correctly.
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FYH 2 Bolt Flange Unit NANFL20723, 1-7/16" Bore Dia., Eccentric Collar Wide inner-ring eccentric locking collar bearings grip the shaft firmly and they are ideal for industrial and agricultural applications where high torque and heavy loads can cause problems with other locking styles.
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text:
Advances in Medicine
Volume 2014, Article ID 947923, 5 pages
Ivacaftor Therapy in CF Patients: Single Center Experience
1Department of Pediatrics, University of Florida, 1600 SW Archer Road, Suite HD 604, P.O. Box 100296, Gainesville, FL 32610, USA
2Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, 1600 SW Archer Road, P.O. Box 100225, Gainesville, FL 32610, USA
3Division of Pediatric Pulmonary Medicine, Department of Pediatrics, University of Florida, 1600 SW Archer Road, P.O. Box 100296, Gainesville, FL 32610, USA
Received 8 May 2014; Revised 3 September 2014; Accepted 15 September 2014; Published 22 October 2014
Academic Editor: Gernot Zissel
Copyright © 2014 Pritish Mondal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ivacaftor is the first novel cystic fibrosis pharmaceutical that acts at the molecular level to potentiate cystic fibrosis transmembrane conductance regulator (CFTR) function and was first approved for clinical use in 2012. We are sharing our single center experience of five patients: four from pediatric age group and one adult patient. All patients had both subjective and objective improvements in their health. Despite established lung disease, our patients had significant improvement in both their FEV1 (forced expiratory volume in 1 second) and FE and BMI (body mass index). Larger studies demonstrated only 6.7% improvement in mean FEV1 after starting Ivacaftor therapy but their patient population had normal lung function to begin with. In contrast our case series demonstrates that, in patients with established lung disease and diminished lung function, Ivacaftor can be expected to result in much higher recovery in lung function. Mean FEV1 improved by 35% in our case series. Ivacaftor is extremely expensive, costing $300,000 per patient per year requiring lifelong therapy, hence requiring prior authorizations from most third-party payers in the USA. The knowledge shared from our experience will be useful for other clinicians to petition healthcare policymakers on behalf of their patients.
1. Introduction
Cystic fibrosis (CF) is the most common life-threatening autosomal recessive disease in the USA [1]. There is a wide variety of gene sequences in cystic fibrosis and more than 1900 CF mutations have been identified [2]. Although daily airway clearance therapies and pancreatic enzyme replacement are keys to CF management, the introduction of Pulmozyme and the introduction of inhaled antibiotics were two milestones in CF management and have become routine care in established lung disease in CF patients. However, there was no known medication that could correct this disease and its underlying molecular defect until recently. Ivacaftor, also known as Kalydeco, is the first marketed drug which restores the function of the cystic fibrosis transmembrane conductance regulator (CFTR). It was approved by the United States Food and Drug Administration (FDA) in January 2012 for treating cystic fibrosis patients with G551D mutation, older than six years. It has shown to be effective as evidenced by reduction in the sweat chloride content of the subjects as well as by the improvement in FEV1 up to 10 percent [3].
Due to its prohibitive cost (approximately $300,000/patient/year), Ivacaftor therapy requires prior authorization from insurers. These insurers often rely on published postmarketing data in order to add newer therapies to their approved lists. In premarketing clinical trials, Ivacaftor demonstrated sustained improvement in FEV1, body mass index (BMI) and the frequency of pulmonary exacerbations [3]. Recently Rowe et al. [4] published a large prospective study with six-month followup of Ivacaftor therapy demonstrating modest but significant improvement in lung function in relatively healthy patients. We are sharing our single center experience of five patients at the University of Florida Pediatric and Adult Cystic Fibrosis Program. We have followed up our patients for 15 months.
2. Methodology
The University of Florida CF database was queried to identify patients with specific G551D mutation. There were a total of 7 patients with at least one copy of the G551D mutation. Of these, 5 patients were above the age of 6 years who qualified for and were started on Ivacaftor therapy. A retrospective chart review was performed. Pulmonary function results, BMI measurements, radiology, and sputum culture results were extracted. Data collected before and after starting Ivacaftor were directly compared. Three longitudinal data sets of FEV1, FEF25–75, and BMI values were analyzed separately using R software by fitting mixed-effects models to each one of them. "Lmer" command was implemented in the lme4 package of the R library.
3. Results
In this direct comparison, by verbal survey, all patients reported subjective improvement in their health status. None of the patients experienced any adverse effects. There were four pediatric patients and one adult patient who were followed up for at least 15 months after starting Ivacaftor therapy (Table 1).
The mean BMI among pediatric patients was 16.2 kg/m2 at baseline which improved to 20.9 kg/m2 at 15 months (Figure 1). The mean FEV1 changed from 56.2 to 99.7 percent predicted (Figure 2) and the mean FEF25–75 from 40.2 to 90 percent predicted (Figure 3). The adult patient was a 45-year-old female who had been previously diagnosed with advanced lung disease when Ivacaftor was started. Her FEV1 was 23% at 3 months after beginning of the therapy, which changed to 42% at 15 months after Ivacaftor. Her BMI was 29.6 kg/m2 at baseline which did not change significantly with time. Our results yield a value of less than 0.01 for all the three data sets analyzed separately for FEV1, FEF25–75, and BMI. The adult patient was known to be pancreatic sufficient and her obesity was a contributing factor to her diabetes mellitus. Her Hb improved from 7.4% to 6.6% without changing any insulin regimen after Ivacaftor was started. She had one hospitalization for CF exacerbation in the year before starting Ivacaftor though she did not require any hospitalization after Ivacaftor therapy.
Ivacaftor also had an impact on the sputum microbiology (Table 1). Two of our patients had methicillin resistant Staphylococcus aureus (MRSA) before, which could not be isolated after Ivacaftor therapy. One of them, who used to grow nonmucoid pseudomonas before in bronchoalveolar lavage (BAL), is now growing only methicillin-sensitive Staphylococcus aureus (MSSA), since we have started Ivacaftor. In two patients, where pre- and post-chest CT scans were available, there was significant improvement in the radiology findings, which showed decreased mucus impaction, improved bronchial wall thickening, and partial reversal of bronchiectasis despite established lung disease (Figure 4). During the same period, his FEV1 has improved from 26% predicted to 50% after Ivacaftor therapy. The vitamin D level did not change significantly.
4. Discussion
As mentioned previously, Ivacaftor is an expensive medication costing about $300,000 per year per patient, and patients require lifelong therapy [5]. When an exorbitantly expensive, noncurative therapy is approved, no consensus is often made among experts on ethical implications of societal cost. In the USA, third-party payers often require prior authorization to cover the cost of these treatments on individual basis. This is understandable since not all FDA approved drugs live up to the expectations in the postmarketing experience [6, 7]. The third-party payers rely on postmarketing report to approve the drug for routine treatment. Patient support groups are facing challenges to obtain payer approval for Ivacaftor in some countries. Dornase alpha which is now a standard CF therapy had faced a similar challenge when initially marketed [8]. It is estimated that there are only 1200 cystic fibrosis patients in the USA who would qualify for Ivacaftor therapy as it is currently approved. Although this new drug is rather expensive, prices of newly approved medications decline over time. Although our expectations for this treatment are optimistic we remain reserved in our predictions of application.
Rowe et al. conducted a longitudinal cohort study in CF patients with G551D mutations [4]. They assessed several parameters at 1, 3, and 6 months in 151 patients after starting Ivacaftor. They showed that there was significant and sustained improvement in BMI, pulmonary function tests, sweat chloride, cystic fibrosis respiratory symptom score, and mucociliary clearance. Their patients had a mean change of 6.7% predicted in their FEV1 value from baseline. The mean improvement in FEV1 in our patient group was 35%. The discrepancy between our study and Rowe et al.'s study is because of the following reasons. The mean FEV1 at baseline in our patient group was 50%, suggesting that our patients were much sicker with already established lung disease. On the contrary, patients studied by Rowe and coworkers were in a much healthier state with the mean FEV1 being 82.6% predicted. Since they already had their pulmonary functions in the normal range, they did not have much room to gain. All of our patients probably already had diffuse bronchiectasis to start with. They had more room to gain due to decrease in their mucus impaction relieving air flow obstruction as a consequence of Ivacaftor therapy. It is also notable that none of the pediatric patients in our group had mucoid Pseudomonas which may be another reason why they responded so well to Ivacaftor therapy.
An orphan drug such as Ivacaftor tends to be expensive due to smaller customer base and high cost of research and development. In Arkansas, three patients are suing the state's Medicaid [9] program for refusing to pay for Ivacaftor. Although clinicians cannot absolve themselves from the fiduciary responsibilities of health economics, their primary responsibility is to provide the best care for their own patients. At least in the United States, clinicians often have to petition third-party payers on behalf of their patients to get authorization for expensive therapies such as Ivacaftor. Since our study demonstrates that even in patients with established bronchiectasis there can be significant improvement in their pulmonary function, this information would be useful for other clinicians to successfully petition their third-party payers.
In our experience, all patients had significant both subjective and objective improvements in their health. Even in older patients with established lung disease there was improvement in FEV1. However, the effect was more dramatic in younger patients. It is known that the lungs are normal in CF patients when they are born and during their early part of life. However, mucus impaction, hypersecretion, changes in the mucus consistency, and chronic bacterial infection over time lead to irreversible lung damage. The only adult patient in our series who had CF related diabetes showed improved HbA1c% after Ivacaftor therapy. This is consistent with the observation made by Bellin et al. [10] who demonstrated improved insulin secretion in patients with CF related diabetes.
In order to have a greater impact on the long-term outcome, any novel therapy should be started quite early in life. Ivacaftor has not been approved for children under 6 years of age who are most likely to benefit from this drug. However, a clinical trial is underway in this age group and hopefully younger children will soon benefit from this novel therapy. To conclude, although Ivacaftor comes with a cost, it showed sustained improvement in FEV1, BMI, and functional status in all patients without any adverse effects. In our experience, Ivacaftor lives up to the expectation and brings about a new paradigm shift in current CF management.
|Cystic fibrosis transmembrane conductance regulator
|Forced expiratory volume in 1 second
|Forced expiratory flow between 25 and 75% of expiratory flow
|Body mass index
|Food and Drug Administration
|Cystic fibrosis
|Bronchoalveolar lavage
|Methicillin-sensitive Staphylococcus aureus
|Methicillin-resistant Staphylococcus aureus
|Nonmucoid Pseudomonas aeruginosa
|Computed tomogram.
Conflict of Interests
The authors declare that there is no conflict of interests regarding the publication of this paper.
- P. M. Farrell, B. J. Rosenstein, T. B. White et al., " Guidelines for diagnosis of cystic fibrosis in newborns through older adults: cystic fibrosis foundation consensus report," Journal of Pediatrics, vol. 153, no. 2, pp. S4–S14, 2008. View at Publisher · View at Google Scholar · View at Scopus
- "Cystic fibrosis mutation database," http://www.genet.sickkids.on.ca/app.
- B. W. Ramsey, J. Davies, N. G. McElvaney et al., "A CFTR potentiator in patients with cystic fibrosis and the G551D mutation," The New England Journal of Medicine, vol. 365, no. 18, pp. 1663–1672, 2011. View at Publisher · View at Google Scholar
- S. M. Rowe, S. L. Heltshe, T. Gonska et al., "Clinical mechanism of the cystic fibrosis transmembrane conductance regulator potentiator ivacaftor in G551D-mediated cystic fibrosis," The American Journal of Respiratory and Critical Care Medicine, vol. 190, no. 2, pp. 175–184, 2014. View at Publisher · View at Google Scholar
- J. Kaiser, "New cystic fibrosis drug offers hope, at a price," Science, vol. 335, no. 6069, p. 645, 2012. View at Publisher · View at Google Scholar · View at Scopus
- Five withdrawn drugs, 2013, http://www.forbes.com/2004/12/10/cx_mh_1213withdrawnslide.html?thisSpeed=6000.
- Merck hit with $285,000 verdict in fosamax trial, 2013, http://www.reuters.com/article/2013/02/05/us-merck-fosamax-idUSBRE91416H20130205.
- A. Bush, M. E. Hodson, D. M. Geddes et al., "Dornase alfa for cystic fibrosis. Patients should not be denied a safe, effective treatment," The British Medical Journal, vol. 310, no. 6993, p. 1533, 1995. View at Google Scholar · View at Scopus
- "Costly drug vertex is denied, and medicaid patients sue," The Wall Street Journal, 2014, http://online.wsj.com/articles/costly-drug-vertex-is-denied-and-medicaid-patients-sue-1405564205?KEYWORDS=kalydeco.
- M. D. Bellin, T. Laguna, J. Leschyshyn et al., "Insulin secretion improves in cystic fibrosis following ivacaftor correction of CFTR: a small pilot study," Pediatric Diabetes, vol. 14, no. 6, pp. 417–421, 2013. View at Publisher · View at Google Scholar · View at Scopus


text:
Buxton Car Centre Trade Sales Ltd
- Telephone:
- 01298 437974 | 07441 951480
- Unit 20 Tongue Lane Industrial Estate, Buxton, Derbyshire, SK17 7LF
Key factsPrint summary
2 KEYS , Next MOT due 04/07/2020, Last serviced on 05/07/2019 at 6,906 miles, Metallic Blue, 2 owners, *****A LARGE SELECTION OF LOW TAX AND LOW LOW MILEAGE CARS IN STOCK*****, £6,995
This car comes with
Metallic Paint, Air Conditioning, Manual, DAB Digital Radio Receiver, Heat Insulating Green Tinted Glass, Hill Hold Function, RCD 215 Radio System/MP3 Compatible CD Player, Front and AUX-in for an External Multimedia Source, Tyre Pressure Loss Indicator, 2 Speakers, Cup Holders, Front x 1, Rear x 1, Digital Clock, Heated Rear Window, Upholstery - Structure Cloth, Height Adjustable Steering Wheel, Drivers Airbag, Head Restraints Front/Rear, High Level 3rd Brake Light, Isofix Child Seat Preparation, Rear, Electronic Engine Immobiliser, Body - Coloured Bumpers, Full Size Steel Spare Wheel, Rear Screen Wash/Wipe, 12V Socket in Centre Console, 5J x 14 Steel Wheels with 165/70 R14 Tyres
- 201911254734509
- 2015
- 15
- £6,995
- 700
- 7,448
- Cars
- up!
- yCDS3Q40sCc=
Vehicle summary
|Body style
|Engine size
|999 cc
|Fuel type
|Number of doors
|Number of seats
|Gearbox type
|CO2 emissions
|103 g/km
|Insurance group
|Standard manufacturer's warranty (miles)
|No details available
|Standard manufacturer's warranty (years)
|2 years
|Standard paintwork guarantee
|3 years
Performance & economy
|Fuel consumption (urban)
|53.3 mpg
|Fuel consumption (extra urban)
|72.4 mpg
|Fuel consumption (combined)
|64.2 mpg
|0 - 60 mph
|15.3 seconds
|Top speed
|99 mph
|Engine power
|59 bhp
|Engine torque
|70.00 lbs/ft
|1489 mm
|Height inclusive of roof rails
|No details available
|3540 mm
|2420 mm
|1645 mm
|Width including mirrors
|No details available
|Fuel tank capacity
|35 litres
|Minimum kerb weight
|932 kg
|Interior features
|Exterior features
|12V Socket in Centre Console
|5J x 14 Steel Wheels with 165/70 R14 Tyres
|2 Speakers
|Body - Coloured Bumpers
|Air Conditioning, Manual
|Full Size Steel Spare Wheel
|Centre Console
|Rear Screen Wash/Wipe
|Comfort Pack
|Cup Holders, Front x 1, Rear x 1
|DAB Digital Radio Receiver
|Digital Clock
|Heat Insulating Green Tinted Glass
|Heated Rear Window
|Height Adjustable Steering Wheel
|RCD 215 Radio System/MP3 Compatible CD Player, Front and AUX-in for an External Multimedia Source
|Split Folding Rear Seat Backrest 60:40
|Upholstery - Structure Cloth
|ABS (Anti - Lock Braking System) with HBA (Hydraulic Brake Assist)
|ASR (Traction Control)
|Daytime Running Lights
|Drivers Airbag
|EBD (Electronic Brake - Pressure Distribution)
|EDL (Electronic Differential Lock)
|ESC (Electronic Stability Control)
|Electronic Engine Immobiliser
|Front Passengers Airbag
|Head Restraints Front/Rear
|High Level 3rd Brake Light
|Hill Hold Function
|Isofix Child Seat Preparation, Rear
|Power - Assisted Steering, Speed - Sensitive
|Side Head/Thorax Airbag System for Front Passengers
|Tyre Pressure Loss Indicator
Please note
This includes MPG figures which are calculated under European Standards, in test conditions, and will vary under normal driving conditions. The information displayed above describes the typical specification of the most recent model of this vehicle. It is not the exact specification for the actual vehicle being offered for sale which may vary. Specifications for older models may also vary. Please contact us prior to purchase to confirm the exact specification of this vehicle.
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Tyler DeMoss
Admissions Counselor
Staff Positions:
Traditional Undergrad Academics - Admissions ...more
Contact Infox
Tyler DeMoss was born and raised in St. Charles, Ill. His parents, Gary and Laurelyn, have six children; Tyler is the youngest. He is recently married and resides in Muskegon, Mich.
"Cornerstone offers a learning environment that seeks to glorify God in every way. Being part of a greater mission to bring students into this environment makes any work easier. Knowing you are helping young men and woman find their calling helps me to continue to desire doing kingdom work."
- B.A., Interpersonal Communication, Wheaton College
—Drinking Coke


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The work that we are doing for God should be of a higher priority than what we do for man
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How prudently we relate to our work determines whether we will be raised to a higher level of financial prosperity or not
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Man will never reach the higher wisdom,If he can't yet accept the pain of change.
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Wuhayb ibn al-Wird
By the external appearance of your knowledge, you have attained (high) ranks and reverence with the people! So seek with Allah higher ranks and closeness by virtue of your hidden good deeds. And know that these two ranks, one cancels out the other.
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H.R.3894 - Restoration of Fairness in Immigration Act of 2002107th Congress (2001-2002)
BillHide Overview
|Rep. Conyers, John, Jr. [D-MI-14] (Introduced 03/07/2002)
|House - Judiciary
|Latest Action:
|House - 03/18/2002 Referred to the Subcommittee on Immigration and Claims. (All Actions)
This bill has the status Introduced
Here are the steps for Status of Legislation:
- Introduced
Subject — Policy Area:
- Immigration
- View subjects
Summary: H.R.3894 — 107th Congress (2001-2002)All Information (Except Text)
There is one summary for H.R.3894. Bill summaries are authored by CRS.
Shown Here:
Restoration of Fairness in Immigration Act of 2002 - Amends the Immigration and Nationality Act with respect to due process in immigration proceedings, including due process in expedited removal proceedings, judicial review in immigration proceedings, and detention proceedings and detention alternatives.
Introduced in House (03/07/2002)
Directs the Attorney General to make periodic reports with respect to persons detained after September 11, 2001.
Directs the Secretary of State to establish a Board of Visa Appeals.
Revises provisions with respect to: (1) removal proceedings; (2) five-year bars to admission and other grounds for exclusion; (3) family reunification-related visas and grounds of admissibility; (4) voluntary departure; (5) public charge determinations and affidavits of support; (6) asylum and refugee proceedings; (7) asset forfeiture; (8) parole authority; and (9) State personnel performing immigration functions.
Directs the Commissioner of the Immigration and Naturalization Service to establish an Office of Border Patrol Recruitment and Retention.


text:
Jan 8, 2018. And although many avid soda drinkers are probably aware of soft drinks' bad effects on health, this knowledge doesn't stop them from drinking soda. But before the acidity of soft drink reaches the stomach it passes through the other organs that precede stomach in the digestive system thus producing an.
Do You Burn More Fat On An Empty Stomach – Top Secret Nutrition Fat Burner Do You Burn More Fat On An Empty Stomach 10 Foods That.
The Cleaning Power Of Soft Drinks! | A Moment of Science – Indiana. – Aug 22, 2008. Soft drinks contain acid that can be used to clean tarnished metal. Let's begin with a. Acids, like the weak acid present in your can of Coke, can react with oxides to effectively reverse the process of tarnishing. The acid. can of Coke. Indeed, stomach acid would be an even better tarnish remover than cola!
Toothpaste, peroxide, baking soda, and cold cream were regular ingredients in.
Lime juice and baking soda A great remedy for many ailments. cinnamon prevents gas formation by reducing the secretion of gastric acid and pepsin from the.
There are 25 body types in total, and some of them include the Adrenal body.
Proton pump inhibitors rank among the top 10 prescribed classes of drugs and are commonly used to treat acid reflux, indigestion, and peptic ulcers. Although.
While dehydration can slow metabolic rate, most lemon-water-linked weight loss.
Nov 30, 2013. All soft drinks cause acid reflux (stomach acid rising up past the esophageal valve). This is more pronounced when the body is horizontal (as in sleeping), but the sheer volume of Coke and soft drinks consumed in the USA means the acid reflux is well past the danger point. Anytime you ingest a an acidic.
30-Day Challenge to beat the soda addiction!. I wish I COULD break the soda habit! It's destroying my teeth, because of the acid, and I've put on SO much weight!
Sep 19, 2015. The compression around your chest and stomach can make heartburn symptoms worse. Put down the bottle: Stop drinking alcohol, carbonated beverages, and drinks containing caffeine like coffee and Coca-Cola ASAP. Chew gum to increase saliva production, helping to neutralize stomach acid.
Top 10 Heartburn Foods. From coffee to grapefruit — helpful tips for avoiding those enticing foods that may just trigger your heartburn.
Despite the pig stomach growing to three times its initial size, it did not blow up even after time was allotted for digestion. In another stomach used as an experimental counterpart, only a large amount of sodium bicarbonate along with acid and soda (and without any Pop Rocks) was able to cause a gastric rupture.
Pop Rocks is a candy with ingredients including sugar, lactose (milk sugar), and flavoring. It differs from typical hard candy in that it creates a small popping.
1. A spoonful of baking soda… A spoonful of sodium bicarbonate, or teaspoon-full to be exact, can help put an end to the gnawing, burning, sensation of heartburn.
Americans are drinking more soda pop than ever before. These popular beverages account for more than a quarter of all drinks consumed in the United States. More than 15 billion gallons were sold in 2000. That works out to at least one 12.
A 2015 study also found that lemon juice may help ward off the stomach flu. Secondly. drinking it in place of soda or other sugary drinks), rather than a.
I said I can't stomach fried food because of a hiatal hernia. They completely edited that part out!" One of the main symptoms of the condition is an acid reflux,
Does this mean I'm going to get Barrett's esophagus? Is there anything I can do, other than wait and see? Are there any treatments available? ANSWER: Gastroesophageal reflux disease (GERD), a condition where acid from the stomach.
No more soda, sugary cereal or ice cream in the house. I am guilty of this; my boys beg me to buy Pop-Tarts, but I haven't because they scream processed food unhealthiness. What has happened as a result of my refusal? My boys.
Jan 8, 2013. While the researchers couldn't fully explain how Coca-Cola removing the blockages, the liquid has an acidity level that resembles that of gastric acid, which is thought to be important for fiber digestion. Not only that, the sodium bicarbonate in Coke has a loosening effect that, when combined with bubbles.
Soda. NEUTRAL pH, 7.00. Dentin dissolves below, 6.50. Enamel dissolves below, 5.50. A&W Root Beer (can), 4.75. Diet A&W Root Beer, 4.53. Barq's Root Beer, 4.47. Acids. Battery Acid, 0.00. Hydrochloric, Sulfuric, and Nitric Acids, 0.00-1.00. Stomach Acid, 1.50-3.50. Phosphoric and Sulfamic Acid, 2.00. Sports Drinks.
What makes soda-drinking kids so unruly? "Soft drinks are highly processed products containing carbonated water, high-fructose corn syrup, aspartame, sodium benzoate, phosphoric or citric acid, and often caffeine, any of which might.
The 3 Worst Foods to Eat & Why – BC Family Chiropractic – 6) Heartburn (acid reflux) – Heavy consumption of soda neutralizes stomach acid leading to heartburn. 7) Osteoporosis – Soft drinks containing phosphoric acid are definitely linked to osteoporosis (a weakening of your skeletal structure) because they lead to lower calcium levels and higher phosphate levels in your blood.
Why is soda acidic and how does the phosphoric acid in cola reduce hydrochloric acid secretion in your stomach and cause digestive health problems?
This reaction happens when the (OH-) ions of the baking soda (sodium bicarbonate) and the hydrogen (H+) ions within the hydrochloric (stomach) acid ( HCL). Use Fermented Drinks: Fermented drinks such as ACV, coconut water kefir and lemon water (not fermented) contain organic acids that have an anti- microbial.
Gerd Pathophysiology Wiki Aug 14, 2010. This review focuses on the pathophysiology of gastroesophageal reflux disease ( GERD) and its implications for treatment. The role of the natural anti-reflux mechanism (lower esophageal sphincter, esophageal peristalsis, diaphragm, and trans-diaphragmatic pressure gradient), mucosal damage, type of. Gastroesophageal reflux disease (GERD) is a chronic medical problem involving the part of the
Here's why: When you vomit, the gastric acid from your stomach enters your mouth. Instead, rinse your mouth with a mixture of baking soda (which helps to.
8 reasons why people drink soda and & 16 good reasons to stop drinking it.
Mar 22, 2016. "That's not necessarily the best thing for the stomach," gastroenterologist Braden Kuo of Massachusetts General Hospital tells STAT in a recent video interview. Between the carbonation, the acidity, and the cold of a soda straight from the fridge, it's just about the worst thing you can drink. However, Kuo.
Nov 6, 2017. Baking soda, also known as sodium bicarbonate, is a natural substance created by your body to buffer acid build-up. This occurs because each system in your body must maintain a specific pH level for proper function. Manufactured baking soda isn't new- it actually appeared on the market in 1846.
Soda might be refreshing but it can seriously damage your health. Here's why you should avoid it all costs.
Jan 10, 2013. Dentists, doctors, moms everywhere, and Mike Bloomberg have told us why Coca-Cola and other soft drinks are bad for you. But wait! According to new research, studies in the last ten years have shown that the fizzy drink you loved as a kid will help you digest. "Coca-Cola ingestion should be the treatment.
Aug 13, 2012. Both drinks can trigger acid reflux. When this happens, stomach acid "can come back up into the esophagus, and that's reflux," Ghassemi says. Alcohol, coffee and other caffeinated beverages can relax the sphincter muscle at the lower end of your esophagus, allowing stomach acid to come back up.
You fumble through platitudes while monitoring a stomach so full of beer, nachos, wings, guac, and tiny hot dogs that you fear you may have a Pop Rocks in soda.
This is also called gastric reflux disease or acid reflux disease. The burning you experience is due to the mucosal damage caused by the stomach acid that travels. Dilute alcoholic beverages with water or soda. Drink moderate amounts.
Aug 28, 2017. Caffeinated Drinks. Caffeine relaxes the LES or Lower Esophageal Sphincter, allowing stomach acid to travel back up the esophagus. Both coffee and tea contain caffeine, along with some sodas, which is why they are best avoided. Coffee also stimulates gastrin release and gastric acid secretion. In fact.
Nearly all carbonated soft drinks contain carbonic acid, which is moderately useful for tasks such as removing stains and dissolving rust deposits (although plain soda water is much better for some. By comparison, the gastric acid in your stomach's digestive fluids is much stronger than any of the acids found in Coca-Cola.
Jan 28, 2018. With Americans consuming this large amount of soft drinks each year, it becomes important to evaluate how soft drinks can influence a person's health. With a little research, Phosphoric Acid also interacts with stomach acid, slowing digestion and blocking nutrient absorption. Artificial Sweeteners– In diet.
Baking Soda (sodium bicarbonate) Questions including "Can you use Arm and Hammer baking soda in your swimming pool" and "Can you use baking soda instead of.
Acids in soda are also known to exacerbate gastroesophageal reflux disease and ulcers."Phosphoric acid from these drinks is in fact an anti-nutrient, as it neutralizes the hydrochloric acid in your stomach and destroys the capacity of the body to absorb essential elements like iron, calcium and magnesium. Damaged.
Stomach Problems. Karl King #1. Subject: Stomach Problems. My experience is that taking a good amount of salt with too little water, like a swallow, can lead to a.
The three main types available to consumers—caustic, oxidizing and acid—work by using harsh chemicals that heat. and attracts and coils hairs around itself.
REFINERY29 name & logo and R29 logo are trademarks of Refinery 29 Inc.
Experiencing heartburn? Learn all about the home remedies for acid reflux that totally work.
Carbonated water (also known as sparkling water, seltzer water, seltzer, bubbly water, or fizzy water, or the closely related club soda or soda water) is water into.


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