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Associate UX Designer
The Marketing Store, a HAVI company, is a privately held global Agency that innovates, optimizes and drives marketing promotions and supply chains of many of the best known brands in the world. When you work at The Marketing Store, you have a chance to make your mark – to be a part of work that drives value, brings a smile and keeps everyday life moving forward. Which means it's not the size of our global footprint, but rather your personal fingerprint, that has the power to make a real difference for our customers… and to touch the lives of people both at home and around the world.
We are staffed by a senior team of classically trained marketing professionals. Having developed an insightful, strategic, brand-building process for creating advertising campaigns, we have adapted this same thinking to promotions, digital, direct, the Internet, CRM, loyalty, premiums and events. The result is unique solutions that cover the gamut of marketing channels. Our clients include McDonald's, Nissan, Infiniti, T-Mobile and more!
Us – We have a long history as an innovative global marketing agency creating end-to-end solutions for our clients. From retail to packaging to toys to digital promotions, The Marketing Store has been blazing a trail for years and years.
You – You can create best-in-class user interfaces in your sleep. You're driven to take UX to the next level, while never forgetting about the core user. You work seamlessly with strategy AND designers, while being able to speak tech with the developers.
Some Tasks You May Be Doing
- Building and maintaining all user experience documentation: site maps, consumer flows, wireframes, and clickable prototypes.
- Developing interfaces for various digital platforms – mobile web, app, and miscellaneous interfaces/displays.
- Working with creative design team to bring UI to life.
- Optimizing existing interfaces based on analytical insights and consumer testing.
- Writing end user UX tests and managing the testing process.
- Collaborating with strategy to best determine end user need states and functional solutions for achieving client goals.
- Bridging internal stakeholders: strategy, creative, and technology.
- Presenting wires and UI to external stakeholders: marketing, technology, product, etc.
- Interpreting data analytics to optimize consumer pathways and conversions.
- Being the end-user advocate throughout the project process and lifecycle.
Desired Skills & Experience
- 2-4+ years in an agency or software UX/UI role
- 2+ years mobile app UI experience
- Robust experience with mobile app best practices across Android and iOS
- Experience with Photoshop, Illustrator, or Sketch
- Experience developing UX & UI for mobile applications
- Experience using Sketch, Invision, and other UX/prototyping software
- Experience designing fully responsive mobile-first interfaces
- Ability to breakdown complex ideas to internal and external stakeholders
- Strong comfort level with coaching clients without UX experience
Nice to Haves
- Knowledge of persona best practices
- Experience putting together focus groups (digital or offline)
- Experience with Jira
- Experience with sweepstakes and promotions
The Marketing Store provides comprehensive benefits offerings to all full-time employees starting on day one. Our benefits include options for medical and dental insurance, 401(k) plan with Company matching provision, profit sharing, flexible spending accounts, tuition reimbursement, life insurance, health and wellness benefits (including discounts on products & services), employee assistance program, and disability insurance.
Thank you for your interest in The Marketing Store.
Please note that we will only contact candidates who are selected for an interview.
The Marketing Store is an equal opportunity employer.
We do not accept unsolicited calls, resumes or candidate referrals from recruiters and agencies.


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Rupert, Rupert & Rupert
Rupert is a struggling actor, Rupert is struggling to find love, and Rupert is struggling to know who he is in bittersweet British drama Rupert, Rupert & Rupert, which is set for its world premiere this spring with a limited theatrical and digital release thanks to Substantial Films.
This rollercoaster ride follows budding actor Rupert Lindsay (Sandy Batchelor) who is desperate to get his big break in acting, but there's one slight problem: he keeps having angry and lascivious outbursts and he can never remember what he did, what he said or even who he hurt. A chance audition puts him in front of failed film director Geoffrey Morton (Ben Porter - Casualty, The Bill), whose last hope in the industry rests on finding a star who can effectively portray the lead in 'The Fatal Blasphemy of Jeremiah Ulysses's Boundless Rage.'
Rupert's angry outbursts have never looked so good, but his psychotherapist Angus (Adam Astill - Unforgotten, Eastenders) wouldn't agree. Trying to keep his disorder in check, Angus is concerned about how Rupert will cope with the pressure of having the success of the play resting on him losing control.

subset: commoncrawl


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Dear Friends,
Greetings from Bal Asha Trust!
Bal Asha Trust team has always worked in the best interest of children. We are ready to face hardships ourselves if it will help in providing the child with a better future in his or her own family. We are very happy to share that we succeeded in finding a happy and safe family for an older child.
Little Chandani was found in 2014 when she was barely 4 years old. She was found in a remote corner in North India. She lived in a children's home for three years, till the authorities there realized that she did not belong to that region.
During a chance conversation, she mentioned the name "Victoria Terminus Railway Station" a well-known location in Mumbai. They immediately transferred the child to an institution in Mumbai.
Bal Asha Trust provides support to few children's home in Mumbai. The social worker of the institution where Chandani lived asked a Bal Asha social worker for help. Bal Asha Team decided to take the child under its wings as we are experienced in handling such sensitive cases.
Our team made intensive efforts to find and identify her biological parents or any relatives with the help of the Police, media and another NGO but sadly, no information was received regarding her biological guardians. Almost 6 months had passed before she was legally declared "Free for Adoption".
Through the concerted efforts of Bal Asha team and their dedication, the now 8 years old child got adopted by a beautiful and well settled family. Today, she lives happily with her family and is moving ahead in life on a positive note.
We thank each one of you for your support to Bal Asha so we can work together towards a better future every day for our children. Please continue to support us.
Thanks and regards,
Sunil Arora
Executive Director
PS: Identifying information is changed to protect the child's identity.
The months of summer bring about some of the happiest times in a child's life – their summer vacations! These two months of excitement and joviality have a massive impact on a child's life, since it helps them break off from their monotonous school routine and helps them to explore different sides of their personality and enhance their creative skills by engaging in a whole melange of activities.
This is exactly how the kids at Bal Asha Trust spent their summer vacation, by getting involved in a variety of activities held as a part of the Summer Fiesta, which are not only meant for the kids to enjoy but also to help the develop their creative abilities.
The months of April and May were filled with a variety of different activities for the children, ranging from drawing, painting, pottery and clay modelling. The kids experimented with different forms of crafts, such as origami and doll making, hence creating exceptional pieces of art.
For the kids to gain exposure to the outside world, many outdoor trips had been arranged for the them. One such trip was to the Magazine Street Kitchen, where the kids gained an insight into the working of a professional kitchen and the amount of hard work it takes to put a lip- smacking dish on our plates later that week they visited a village themed restaurant for lunch. The kids also visited the Zoo and the Prince of Wales Museum, which took the kids on a trip through time, as they were furnished with knowledge about our ancient country's past, and that of other countries too. The kids also paid a visit to the Kidzania playpark, where the kids enjoyed playing the roles of actual professionals in a variety of fields and it helped them realise how the adult world works.
In honour of the recent coronation of the King of Thailand, the Thai general Consul of India visited Bal Asha Trust and donated many things which are necessary for taking care of our children. He spent time with the children and applauded the work which is being done here for the past 33 years.
The kids not only enjoyed these activities, but also learnt important lessons which will surely help them in later stages of life. This summer fiesta was enjoyed not only by the children but also by the Bal Asha staff, since they too accompanied kids on their outdoor adventures and assisted them in their indoor activities, thus establishing a strong bond between the adults and the kids.
We had many corporates, such as the Morgan Stanley Group, the Union Bank, DHL, the Giants Group and the Asian Teachers Association volunteer with Bal Asha and assist the kids in their activities and accompany them on their trips. The whole Bal Asha team and a wide range of volunteers who have assisted us in every step of this Summer Fiesta are the family of these kids while they are in Bal Asha Trust.
Now, the summer season has passed and schools have reopened. All these trips and activities have been funded by donations of patrons such as yourself. This Grand Summer Fiesta would not have been possible without the patronage of our large-hearted donors.
We politely urge you to donate to Bal Asha so that we continue to serve our mission of providing these wonderful children with care and nourishment.
Thank you!
Dear Friends,
Greetings from Bal Asha Trust!
In our september 2018 project report we had shared with you about Devi 's admission to Bal Asha Trust from an orphanage about 400 kms from Mumbai.
She had gone through a surgery for her right foot congential deformity in september 2018.
I am very happy in sharing that the surgery was sucess and the child is doing well. She recently turned 1 year old. She is doing well developmentally. She sits by herself. She has started crawling all over the place. She loves moving around all by herself and smile with other children in the infant unit of her age. Nutrionally she is doing well. She was 3.54 kgs when she joined the Bal Asha family and today she is 6.41 kgs. She has grown tall too, she was 53 cms on admission and today she 61 cms. She is receiving required therapy from our occupatoinal therapist and intervention, so she does much better in the coming months.
We thank each one of you for the support so we can continue to take care of our babies in the best possible way.
We have increased our fundraising goal as the project is ongoing. We will continue to provide best quality care to children in our care from you help. Thank you for your donation.
Thanks and regards
A beautiful story unfolded around Christmas.
Child Anil* about five years got separated on weekend. Anil's parents are living in slums in Mumbai. His father has a shop on the street and his mother is a housewife. She has to take care of two younger children other then Anil. The youngest of the siblings of Anil is barely a month old.
Anil was playing near the house, but he lost his way back. He boarded a train and reached to a major train terminal. The cops on the railway station saw a now visibly scared Anil. They spoke to him and realized that he could not share any details about his residence. The cops informed child welfare authorities. The authorities asked the cops to take the child to Bal Asha Trust so that he can receive quality care, nutrition, medical and counseling. Bal Asha team was very happy take Anil under its wings. During medicals the team realized that he has squint and orthopedic issues. Immediately as per doctor's advice he was started on vitamins.
Soon on the other side Anil's mother realized that he has not come back home even after couple of hours. She called her husband and they began to search for him in nearby areas. They decided to inform the police station in the area. The police started searching for whereabouts of Anil. The CCTV on the station did show Anil coming into the railway station, but at the same time two trains stopped on the platform both going in opposite directions, hence they had no clue in which direction he went.
The cops then started giving information to their collogues posted at different stations in both directions.
Two days later the search ended when both the police stations connecting, and it was emotional moment for everyone involved in the process. Anil immediately recognized his family. The family was very happy to have him back in their arms. The social worker shared about the medicals of Anil with the family and asked them to provide proper medical attention to him. This is a true blessing for any family.
We wish each one of you lots of blessings this Christmas.
Thank you for supporting our work through GlobalGiving and hope that you will help us in 2019!
A little early…Happyyyy New Year 2019!
Thanks and regards,
Diwali Greetings to you !
Diwali festival of lights, smiles, food and family. It also marks school vacations for children who look forward to a trip outside the city.
Children without families also have dreams of celebrating Diwali. We at Bal Asha Trust understand this very well and plan Diwali for our children much in advance as family.
This Diwali vacations are special as apart from wonderful festival plans we planned a trip for the kids to Lonavala. Lonavala is a hill station about 100 kms from Mumbai.
The planning included travel, stay, clothes, medicines, special diet, food and fun activities for them.
The children had an amazing time exploring the town and doing different activities. They visited a Wax Museum, Dinosaur Park, Game World, 9D Cinema & Mirror Maze over two days. They also enjoyed lovely home cooked food at a kitchen ran by a family and had a snack at McDonalds. They danced to Bollywood music and played games. They are back to Bal Asha home with happy memories.
We are so thankful for the support we receive from our donors so that we could give wonderful trip to our children.
We wish you and family a great Diwali festival season. May this festival bring lots of love, laughter, health and wealth to you and your loved ones. If you wish to make a donation this festive season, please do click on the "Give now" button and share with your friends and family.
Thank you !
Project Reports on GlobalGiving are posted directly to globalgiving.org by Project Leaders as they are completed, generally every 3-4 months. To protect the integrity of these documents, GlobalGiving does not alter them; therefore you may find some language or formatting issues.
If you donate to this project or have donated to this project, you will get an e-mail when this project posts a report. You can also subscribe for reports via e-mail without donating.
We'll only email you new reports and updates about this project.
Support this important cause by creating a personalized fundraising page.Start a Fundraiser


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A terminally ill Texas man is spending his last few weeks surrounded by friends and family.
He had a request in his final weeks, his favorite beverage, a cherry 7up. But, that can be tough to come by in some areas.
"I don't know. I've always liked 7up. I like the cherry," said Don Chaney. "And the two of them together just gives you a little oomph. I just got started drinking it, so that's about all I drink."
Don moved back to his longtime home of Abilene just last week, but when he asked for his drink of choice, things got a bit tricky.
"They got none," said Chaney. "None whatsoever."
The search for Cherry 7up led to United Supermarket. Now they didn't have any in stock, either, but that wasn't the end of it.
"After I called the Pepsi vendor, they notified me that they're not allowed to sell the Cherry 7up here in Abilene, due to some kind of contract they have with Dr. Pepper," said Sergio Aguillon, United Supermarkets. "My store director here, Crystal, I guess pushed me not to take no for an answer every time."
Sergio says he didn't know this story would end the way it did.
"I went ahead and asked him if there was any way. I was like, 'Can you just get a case thrown on the truck to get it over here?' He was like, 'There's no way to get it here,'" said Aguillon.
But Sergio wasn't going to just give up.
"So, I went to the second best option, which was our district manager, Cale. They ended up having two twelve packs of Cherry 7up in their garage," said Aguillon. "We ended up picking it up that night. They were really grateful about it. She asked me for a hug, and I gave her a pretty big hug, yeah."
Don's been reunited with his favorite drink, but it goes beyond just a can of soda.
"It was flooring. I was surprised, very surprised. You just don't find that in many stores anymore," said Chaney. "It used to be a common thing. I think it's not so common anymore, but you do find a little of it."
Don's son will be visiting soon, and he's expected to bring a fresh supply of that special soda with him.


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Enter your search criteria into the boxes below, then click the search icon or press enter. In the What box, you can type the job title, keywords, or job posting number. In the Where box, enter a city, state or zip code. You can also enter a county name and the state, such as Coosa County, AL. In the Within box enter the number of miles around the location entered. If either the Where or Within boxes are going to be used, then both boxes are required. To narrow your search results, use the "Refine Search" filters on the left by selecting a category. The number next to each filter indicates the number of results currently in the system using that filter, plus your current search criteria. If zero jobs meet the criteria, the filter will not display for selection. Results do not include indeed.com jobs. Filters can be removed by selecting the link you want to remove in the "Filtered By" section. Searches can be saved by entering a unique name in the Label field and selecting the "Save search as" button.
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Obsolescence/Supply Chain Analyst (2770579)
Last Updated: 2019-12-07
Employer: TMC Design CorporationLocation: Huntsville, AL
Job Summary
Support Missile Defense Agency mission and quality assurance by participating in multi-disciplinary teams conducting quality and mission assurance evaluations and assessments for existing missile defense components and architectures. This role will provide technical expertise in Quality and Mission Assurance Management in performing oversight of all lifecycle phases including…
Electrical Components Engineer (2770570)
Last Updated: 2019-12-07
Employer: TMC Design CorporationLocation: Huntsville, AL
Job Summary
Support Missile Defense Agency (MDA) mission and quality assurance by participating in multi-disciplinary teams conducting quality and mission assurance evaluations and assessments for existing missile defense components and architectures. Responsibilities will involve analysis of electrical and electronic components and assemblies. The individual should have knowledge of…
Manufacturing Engineer- Entry Level (2770176)
Last Updated: 2019-12-06
Employer: Johns ManvilleLocation: Scottsboro, AL
The purpose of the Manufacturing Engineer's role will be to provide technical support to operate a major asset (or technical leadership to a smaller asset) at target regarding output, usage of material and energy by meeting the product specifications. To achieve that goal, the Manufacturing Engineer needs to use a…
Electrical Design Engineer (2770091)
Last Updated: 2019-12-06
Employer: Kratos Defense & Rocket Support Services, Inc.Location: Huntsville, AL
Job Tracking ID: 85347-298056
Location: Huntsville, AL
Job Type: Full-Time/Regular
Date Updated: December 06, 2019
Job Description:
The Advanced Concepts, Development, and Test (ACDT) group of Kratos Defense is seeking a highly motivated individual to join our team to provide Electrical Design and Test support for our tethered…
System Safety Engineer 500373 (2766071)
Last Updated: 2019-12-06
Employer: IronMountain SolutionsLocation: Huntsville, AL
IronMountain Solutions, Inc. is currently seeking a highly qualified System Safety Engineer for the Huntsville, AL area supporting our customer on Redstone Arsenal. An ideal candidate will be able to manage complex projects, work effectively with others and manage multiple projects simultaneously. A successful candidate must have the ability to…
Sr. Quality Engineer (2770040)
Last Updated: 2019-12-06
Employer: Stanley Black & DeckerLocation: Decatur, AL
- Serves as a primary point of contact for AS, ISO, Nadcap, and all other QMS and customer quality audits.
- Maintains and modifies documentation in support of all Quality Management Systems, QMS, (e.g. ISO9001, AS9100, ISO-17025, Nadcap NDE, and other programs as…
Senior Project Engineer, Human Space Flight Subjec (2770000)
Last Updated: 2019-12-06
Employer: The Aerospace CorporationLocation: Huntsville, AL
Requisition ID: 47092
All Locations: Huntsville, AL (Alabama)
A trusted partner. A national resource. A leader in national security space. We are THE Aerospace Corporation. A team that takes pride in our readiness to solve some of the most complex technical challenges in existence. With challenges spanning clandestine to commercial…
Engineering Technician (2769994)
Last Updated: 2019-12-06
Employer: Sanmina CorporationLocation: Huntsville, AL
Category (For Job Seekers)
14381 – EMS Huntsville AL US – Huntsville, 35803 US (Primary)
Job Description
US Citizenship is Required
Position Title: Engineering Technician
Position Overview:
Supports engineering activities such as design, test, check-out, modification, fabrication and assembly of prototype electro-mechanical systems, experimental design circuitry or specialized…
Sustainment Engineering Manager (2769929)
Last Updated: 2019-12-06
Employer: CubicLocation: Huntsville, AL
Job id : REQ_21050
Job Details:
Job Summary:
Develop and manage a group of engineers to support shop floor production activities, FRACAS, EOL, DMSMS and field support initiatives. Sustainment team is cross functional including electrical, mechanical and reliability engineers to track and resolve issues, estimate field reliability based…
RF Test Engineer (2769469)
Last Updated: 2019-12-05
Employer: Mercury Systems, Inc.Location: Huntsville, AL
Job Title
RF Test Engineer
San Jose CA USA-73370
Job Description
In this role, you have the opportunity to
Test, tune and troubleshoot complex, multi-function, RF/microwave surface mount assemblies for High Quality RF Products.
You are responsible for
- Tuning and testing of RF/microwave surface mount assemblies
- …
- Registered Apprenticeship


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The Mavericks
- October 21, 2019 - Showtime: 7:30pm
TCU Place (Saskatoon Centennial Auditorium & Convention Centre)
35-22nd St E, Saskatoon, SK, CA
- Advance Cost: $67.50
- Door Cost: $67.50
Tickets are $67.50 available online HERE
LISTEN TO THE 30th ANNIVERSARY SPOTIFY PLAYLIST: HERE
In 2019, multi-platinum, Grammy-winning, rock'n'roll-country- Tejano phenomenon THE MAVERICKS celebrate 30 years of entertaining millions of people around the world with a whirlwind of new activity.
The Miami band – back and better than ever since their reunion in 2012 – will mark three decades of uniting great Latino and American music traditions with a series of special events to celebrate this great band's past and look forward to the future. Over the summer, the band will launch a unique version of their renowned live show that has won over crowds across the world, including appearances at some of the finest venues in Europe, Canada, the US and the UK.
With special staging and a unique narrative this anniversary show will reimagine THE MAVERICKS' catalogue, from their early days in Miami's punk and alternative scene, through their chart-topping years in the 90s and 2000s and right up to their reunion and creative rebirth. As well as telling the story of THE MAVERICKS, the shows will chart the many ways in which they have intertwined traditional Tex-Mex, Latino, Norteño and Tejano music with country, rock'n'roll and the great American songbook – a true American story of cross-cultural inspiration.


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Revere case study
1 . I would do the next 4 researching the market and organizing before investment an apartment: Research on the whole market, especially the industry for tiny apartment properties: To recognize whether the market is going up, for example , simply by analysis the trend of the capital ratios, and then get the whole picture in the real estate market. To make a segment exploration on the market of small condo buildings. Following collecting the data from the selling prices and rents, to forecast unique worthwhile to invest in the market of small apartment. To search for several expenditure targets and, for example , to decide an ideal town or even non commercial section to get the building, taking location, situation, broker, etc into consideration. To make the cash flow and expenditures projections and get a draft of the expense setup: With the information gathered in the first step, to set affordable assumptions, including rents, openings, renovation price, operating bills, etc and calculate the near future cash flow, potential profits and expected returning. To work with scenario analysis, if necessary, and alter the assumptions under several market circumstances to get a whole picture of future possibilities. Planning pertaining to own fairness base and making an investigation for the mortgage industry: To make certain about my very own savings and cash utilized for real estate investment in addition to the budget in the following years. To visit saving banking institutions and find out the mortgage or loan which can be provided. To get legal advice on the upcoming transaction and estimate conceivable risks.
The main factors I possibly could focus on happen to be
The expected earnings of the whole market: By simply analysis the expected returning of the whole real estate market, I will decide whether it is an ideal time for you to invest. The expected come back of potential investment building: By generating my potential investment come back and evaluating it with the return from the real estate and also financial...


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Events for May 27, 2019
Events Search and Views Navigation
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4:30 pm
Salvation Army Open Gym
FREE Open Gym Ages 12-18 Please wear gym attire (athletic shoes, t-shirts, shorts or sweat pants) For more information and questions please contact: Al Green Community & Athletic Ministry Coordinator Salvation Army Fountain Sq. Indianapolis. IN 46203 317-632-0156 ext. 105Find out more »
5:30 pm
Arthur's Music Store Bluegrass Jam
Join us for Bluegrass pickin'! Every MONDAY 5:30-7:30pm at Arthur's Music Store - 931 Shelby St! FREE and Everyone is Welcome! Even if you don't play an instrument, come hang out and tap your foot! Check our Facebook and Instagram for the latest info about the Arthur's Music Store Bluegrass Jam. @ArthursMusicStore We will not […]Find out more »


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"Hiking is a bit like life: The journey only requires you to put one foot in front of the other…again and again and again. And if you allow yourself the opportunity to be present throughout the entirety of the trek, you will witness beauty every step of the way, not just at the summit" Unknown
Photos are from my most recent journey into the woods with several of my RezBro friends on the Lakeshore Trail adjacent to Lake Chelan.
Share the joy


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Psycho_Werkatze's Multi-coloured hair
Psycho_Werkatze — 2/11/2013
the shit is growing so fast! since i started working in sept. i didnt have too much time taking photos of my hair. i had it all a dark gree before this so i had to cover it with a dark color. its mostly an aubergin-ey purple that blends into pinkish red bangs. end i love the fact that i can call them "bangs" again :D also, the catears are back :) , will post it as soon as i have time to do them:3


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118 3 Bedroom Apartments for rent in Lakewood, OH
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December 2019 Lakewood Rent Report
Welcome to the December 2019 Lakewood Rent Report. Lakewood rents remained steady over the past month. In this report, we'll evaluate trends in the Lakewood rental market, including comparisons to cities throughout the state and nation.
December 2019 Lakewood Rent Report
Welcome to the December 2019 Lakewood Rent Report. Lakewood rents remained steady over the past month. In this report, we'll evaluate trends in the Lakewood rental market, including comparisons to cities throughout the state and nation.
Lakewood rents increased over the past month
Lakewood rents have remained steady over the past month, but are down significantly by 3.7% year-over-year. Currently, median rents in Lakewood stand at $619 for a one-bedroom apartment and $771 for a two-bedroom. Lakewood's year-over-year rent growth lags the state average of 1.3%, as well as the national average of 1.4%.
Rents rising across cities in Ohio
While rent decreases have been occurring in the city of Lakewood over the past year, cities in the rest of the state are seeing the opposite trend. Rents have risen in 8 of the largest 10 cities in Ohio for which we have data. The state as a whole logged rent growth of 1.3% over the past year. Here's a look at how rents compare across some of the largest cities in the state.
- Looking throughout the state, Columbus is the most expensive of all Ohio's major cities, with a median two-bedroom rent of $969; of the 10 largest cities in Ohio that we have data for, Youngstown and Cleveland, where two-bedrooms go for $727 and $784, are the two other major cities in the state besides Lakewood to see rents fall year-over-year (-0.9% and -0.5%).
- Lorain, Hamilton, and Columbus have all experienced year-over-year growth above the state average (3.3%, 1.8%, and 1.7%, respectively).
Lakewood rents more affordable than many large cities nationwide
As rents have fallen significantly in Lakewood, many large cities nationwide have seen prices increase, in some cases substantially. Lakewood is also more affordable than most large cities across the country.
- Lakewood's median two-bedroom rent of $771 is below the national average of $1,191. Nationwide, rents have grown by 1.4% over the past year compared to the 3.7% decline in Lakewood.
- While rents in Lakewood fell significantly over the past year, many cities nationwide saw increases, including Phoenix (+3.9%), Dallas (+2.2%), and Seattle (+1.6%).
- Renters will find more reasonable prices in Lakewood than most large cities. For example, San Francisco has a median 2BR rent of $3,101, which is more than four times the price in Lakewood.
For more information check out our national report. You can also access our full data for cities and counties across the U.S. at this link.
Methodology - Recent Updates:
Data from private listing sites, including our own, tends to skew toward luxury apartments, which introduces sample bias when estimates are calculated directly from these listings. To address these limitations, we've recently made major updates to our methodology, which we believe have greatly improved the accuracy and reliability of our estimates.
Read more about our new methodology below, or see a more detailed post here.
Apartment List is committed to making our rent estimates the best and most accurate available. To do this, we start with reliable median rent statistics from the Census Bureau, then extrapolate them forward to the current month using a growth rate calculated from our listing data. In doing so, we use a same-unit analysis similar to Case-Shiller's approach, comparing only units that are available across both time periods to provide an accurate picture of rent growth in cities across the country.
Our approach corrects for the sample bias inherent in other private sources, producing results that are much closer to statistics published by the Census Bureau and HUD. Our methodology also allows us to construct a picture of rent growth over an extended period of time, with estimates that are updated each month.
Read more about our methodology here.
About Rent Reports:
Apartment List publishes monthly reports on rental trends for hundreds of cities across the U.S. We intend these reports to be a source of reliable information that help renters and policymakers make sound decisions, and we invest significant time and effort in gathering and analyzing rent data. Our work is covered regularly by journalists across the country.
We are continuously working to improve our methodology and data, with the goal of providing renters with the information that they need to make the best decisions.


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For a delectable treat you can call Camila for your place or hotel. She is a very slim girl with big 34Ds, she has lots of energy and really enjoys working as an Escort. She is a 25 year old Colombian girl who you should put on your list to see.Write review
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Van Gaal wants Manchester United players dreaming of victory over Stoke
Louis van Gaal has been telling Manchester United's players to think of beating Stoke while they are in bed.
United will make it eight wins from 10 matches on Thursday if they beat Stoke at the Britannia Stadium.
The idea of travelling to Staffordshire for a lunch-time kick-off on New Year's Day may not appeal to many people -- particularly those who enjoyed a heavy night seeing in the New Year.
But Van Gaal is relishing the opportunity of gaining ground on Manchester City and Chelsea who play Sunderland and Tottenham, respectively, later in the day.
Van Gaal took little notice of Chelsea's and City's slip-ups last weekend -- United themselves failed to take advantage as they drew at Spurs -- and the Dutchman insists only his players will decide whether they become genuine title contenders in the coming weeks.
"You have to always do it by yourself and not depend on results of the opponent," the United manager said.
"You have to be busy with yourself, with your preparation, and the imagination of the game.
All the players have to do that -- dream of the game already, you have to play the game already in your bed."
Although United sit in third position after a nine-match unbeaten run, Van Gaal is yet to see a completely satisfactory performance from his team.
The 3-1 Boxing Day win over Newcastle had the hallmarks of a victory from the Sir Alex Ferguson era, but Van Gaal was still not totally happy.
The Dutchman is so demanding that he says he has enjoyed just a single "perfect" performance from one of his teams during his 27-year-career.
That came 20 years ago when he coached an Ajax team containing the likes of Edwin van der Saar, Edgar Davids and a 19-year-old Patrick Kluivert to a 2-0 Champions League win at Real Madrid.
"That was a perfect game -- the only one in my eyes," Van Gaal said.
"I have not achieved that with Manchester United." The fact that United dropped points at Spurs thanks to Hugo Lloris' brilliance, and at Villa Park, where the hosts played the final 25 minutes with 10 men, still rankles Van Gaal.
"In the last three games -- Aston Villa, Newcastle, Tottenham -- we should have had nine points," the former Barcelona manager said.
"Then, we would [have] four more points and we would be only six points [behind Chelsea]."
Reflecting on his first five months in England, Van Gaal said he had been taken aback by the support he received from United fans despite the club's stuttering start.
"I have never had the experience that when you lose or draw at home that the fans still applaud you, showing their belief in you. Never," Van Gaal said.
"In Barcelona, (they wave) white handkerchiefs. In Bayern, they whistle. In Amsterdam, Ajax, they are shouting for someone else.
"Here, they stand up, and applaud. Unbelievable. That's why I'm thanking the fans because they were very important in my first six months."
Adnan Januzaj and Ander Herrera could return from illness and injury respectively for the Stoke match and Angel Di Maria may feature after Van Gaal played down the seriousness of a pelvic injury.
"He's coming back. It's not serious," Van Gaal said.
Chelsea's Eden Hazard was subjected to a rash challenge by Phil Bardsley when the Blues went to Stoke last week, but Van Gaal is sure the officials will not let Thursday's match turn ugly.
The United manager added: "I think the referee is the most important man on the pitch always in relation to tackles.
"He has to allow it or not. We have Michael Oliver and I think he is a very good referee."
Use a Facebook account to add a comment, subject to Facebook's Terms of Service and Privacy Policy. Your Facebook name, photo & other personal information you make public on Facebook will appear with your comment, and may be used on ESPN's media platforms. Learn more.


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ENFIELD--- July 11 marks three months to the day former Connecticut National Guardsman Josh Devine, 36, vanished while on a diving excursion in Thailand.
While Thailand officials called off the search for Devine, the family still has a lot of questions about what happened to him.
"He's been In war zones since he was 18, and goes missing while on a diving trip. It just doesn`t equate," said Devine's sister Jennifer Bakowski.
Devine's family is offering a $5,000 reward for anyone with information that could lead to his whereabouts.
"We don't want to put anyone else in danger by coming forward, but we need to bring him home. We need closure to this," said Bakowski.
Devine, 36, a U.S. Army veteran who deployed to Kosovo and Iraq, owns land in Thailand with his wife, Thadsana, family members said. He is an experienced diver, and was traveling with her on a dive boat traveling from Phuket, an island province in the Andaman Sea.
Devin's sister Jenniger Bakowski says witnesses have told the family, Devine was drunk and somehow ended up going overboard, but his disappearance went unreported for hours.
"Nobody heard a splash. Nobody heard anything about him going into the water, he just "magically disappeared," Bakowski said.
The family released a document to Fox Connecticut Saturday that details email conversations between Devine's sister, the United States Embassy and an investigative reporter as the family digs for answers. His family has questioned whether foul play was involved.
Jennifer Bakowski and her mother went to Thailand in April to join the governor of Phuket and members of the Thai marine police in their search.
While in Thailand, Devine's family met with U.S. Embassy officials and an FBI agent.
They left without finding any clues to Devine's whereabouts, and the official search ended shortly thereafter.
The family hopes a $5,000 will help anyone come forward with information, past efforts have turned up no credible leads or information.
"We've been told that the Thai community is afraid to go forward. Because people go missing." said Bakowski.
Devine served two tours in the U.S. Army in Kosovo and Iraq and was a Sergent in the Connecticut National guard from 2002-2006. Devine worked as a I.T. specialist for a private military contractor at an army base in Kuwait.


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Sartelli, Massimo and Catena, Fausto and Ansaloni, Luca and Leppaniemi, Ari and Taviloglu, Korhan and van Goor, Harry and Viale, Pierluigi and Lazzareschi, Daniel and de Werra, Carlo and Marrelli, Daniele and Colizza, Sergio and Scibé, Rodolfo and Alis, Halil and Torer, Nurkan and Navarro, Salvador and Catani, Marco and Kauhanen, Saila and Augustin, Goran and Sakakushev, Boris and Massalou, Damien and Pletinckx, Pieter and Kenig, Jakub and Di Saverio, Salomone and Guercioni, Gianluca and Rausei, Stefano and Laine, Samipetteri and Major, Piotr and Skrovina, Matej and Angst, Eliane and Pittet, Olivier and Gerych, Ihor and Tepp, Jaan and Weiss, Guenter and Vasquez, Giorgio and Vladov, Nikola and Tranà, Cristian and Vettoretto, Nereo and Delibegovic, Samir and Dziki, Adam and Giraudo, Giorgio and Pereira, Jorge and Poiasina, Elia and Tzerbinis, Helen and Hutan, Martin and Vereczkei, Andras and Krasniqi, Avdyl and Seretis, Charalampos and Diaz-Nieto, Rafael and Mesina, Cristian and Rems, Miran and Campanile, Fabio and Agresta, Ferdinando and Coletta, Pietro and Uotila-Nieminen, Mirjami and Dente, Mario and Bouliaris, Konstantinos and Lasithiotakis, Konstantinos and Khokha, Vladimir and Zivanović, Dragoljub and Smirnov, Dmitry and Marinis, Athanasios and Negoi, Ionut and Ney, Ludwig and Bini, Roberto and Leon, Miguel and Aloia, Sergio and Huchon, Cyrille and Moldovanu, Radu and de Melo, Renato and Giakoustidis, Dimitrios and Ioannidis, Orestis and Cucchi, Michele and Pintar, Tadeja and Jovine, Elio (2012) Complicated intra-abdominal infections in Europe: preliminary data from the first three months of the CIAO Study. World Journal of Emergency Surgery, 7 (1). p. 15. ISSN 1749-7922
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Članak je dostupan u skladu s odredbama licencije o slobodnom pristupu izdavača BioMed Central (http://www.biomedcentral.com/about/license). ----- THE WORK IS PROVIDED UNDER THE TERMS OF THIS BIOMED CENTRAL OPEN ACCESS LICENSE. THE WORK IS PROTECTED BY COPYRIGHT AND/OR OTHER APPLICABLE LAW. ANY USE OF THE WORK OTHER THAN AS AUTHORIZED UNDER THIS LICENSE IS PROHIBITED (http://www.biomedcentral.com/about/license). ----- The CIAO Study is a multicenter observational study currently underway in 66 European medical institutions over the course of a six-month study period (January-June 2012).This preliminary report overviews the findings of the first half of the study, which includes all data from the first three months of the six-month study period.Patients with either community-acquired or healthcare-associated complicated intra-abdominal infections (IAIs) were included in the study.912 patients with a mean age of 54.4 years (range 4-98) were enrolled in the study during the first three-month period. 47.7% of the patients were women and 52.3% were men. Among these patients, 83.3% were affected by community-acquired IAIs while the remaining 16.7% presented with healthcare-associated infections. Intraperitoneal specimens were collected from 64.2% of the enrolled patients, and from these samples, 825 microorganisms were collectively identified.The overall mortality rate was 6.4% (58/912). According to univariate statistical analysis of the data, critical clinical condition of the patient upon hospital admission (defined by severe sepsis and septic shock) as well as healthcare-associated infections, non-appendicular origin, generalized peritonitis, and serious comorbidities such as malignancy and severe cardiovascular disease were all significant risk factors for patient mortality.White Blood Cell counts (WBCs) greater than 12,000 or less than 4,000 and core body temperatures exceeding 38°C or less than 36°C by the third post-operative day were statistically significant indicators of patient mortality.
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AEthermage's Touch - Foil
In Stock
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Extra Info
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- Card Text: Reveal the top four cards of your library. You may put a creature card from among them into play. It has "At the end of your turn, return this creature to its owner's hand." Then put the rest of the cards revealed this way on the bottom of your library in
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- Name: AEthermage's Touch
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Weekly Wellness: How to treat mosquito bites
Related Story
COLUMBIA- It's a fairly normal experience in Missouri during the summer – mosquito bites. Ugh! Mosquito bites cause an intense itchiness because our bodies release histamine, a compound involved in the body's immune response. Specifically, there are proteins in the mosquitoes' saliva that trigger our skin to get that ugly, itchy red bump.
In many cases, the mosquito bites will clear up in a few days and are totally annoying but nothing serious. The older we get, the less likely we are to develop a serious reaction from the bites. While everyone is different, these remedies might help:
- Try using calamine lotion or hydrocortisone cream. Calamine lotion is formulated to relieve itching and discomfort while hydrocortisone cream can help reduce swelling, redness, and itching.
- Use a cold compress. Applying an ice pack or a col, wet cloth to the bites can help. The cold temperature causes the dilated blood vessels near the surface of the skin to narrow, limiting inflammation.
- Moisturize regularly. When skin is dry it is more prone to irritation and itchiness. Use a gentle cream or lotion daily – when getting out of the shower or bath.
- Take an OTC antihistamine. If you're really struggling, taking an antihistamine can help. An oral antihistamine starts to work within an hour and aims to have a 24-hour effect. Talk with your doctor.
- Mix a baking soda paste. A great DYI solution is combining four parts baking soda to one part water and apply the paste to those itchy spots.
If these remedies fail or your symptoms intensify (i.e. fever, joint pain, red eyes, headache, fatigue), contact your physician.
(Source: https://www.self.com/story/how-to-treat-mosquito-bites)


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Testing Kanister-Enabled Applications¶
The instructions below are intended to help you test Kanister-enabled applications. You can use this guide if you have a Kasten-provided test drive or if you are testing a self-install in your own environment.
Configuring a Kanister Profile¶
The Kanister blueprints provided use an S3-compatible object store to manage data artifacts. To make this storage accessible to Kanister Blueprints, you need to first configure a Kanister Profile from the Settings section of the dashboard or via the CRD-based Profiles API.
Kanister Profile creation is very similar to creating a Migration Profile and you can follow the same instructions. The only significant difference is that K10 currently only supports a single Kanister profile. Once the profile is configured, the information stored in it will be made available to the blueprints for all Kanister-enabled applications so that they can manage data artifacts.
You will need to make sure that the credentials specified in the Kanister Profile have sufficient permissions to perform list, put, get, and delete for the profile location. You will also want to make sure that any retention policy configured on the location allow deletions so that artifacts can be reclaimed based on your intended data backup retention.
Installing Test Applications¶
To facilitate testing, you can install Kanister-enabled applications using Kanister-enabled Helm charts that will install the application instance as well as the appropriate Kanister blueprint to be used with it.
Prior to install you will need to have the Kanister Charts repository added to your local setup:
$ helm repo add kanister https://charts.kanister.io/
The following application specific instructions are available:
Specifying a Kanister Blueprint for Your Application¶
To request K10 to use a Kanister Blueprint to manage a workload (e.g.,
Deployment or StatefulSet), please (a) create the blueprint in the K10
namespace (default
kasten-io) and (b) annotate the workload with
the name of the created blueprint as follows:
$ kubectl --namespace=<app-namespace> annotate <workload>/<workload-name> \
Finally, note that the blueprint used must have a
backup and
restore action defined and ideally a
delete action for
retirement too.
Use Case Testing¶
Once you have installed your application, you will be able to use the K10 Dashboard to bring the application in compliance and protect it by creating one or more policies. You can also subsequently restore the application and its data to a previous version. You can find more detailed instructions in the Protecting Applications and Restoring Applications sections of this documentation.
If you are testing on a cluster that in not running on AWS or GKE you should consider the following limitations:
If the namespace of your application contains additional workloads that use persistent volumes but do not have a Kanister blueprint, you will not be able to use namespace based protection policies. You will still be able to use workload-based policies for the Kanister enabled workloads.


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Premiere: Lolawolf 'everyf–ckinday' EP
Brooklyn-based trio, Lolawolf, is back with a fiesty follow up to the their debut album, Calm Down.
Today (June 23), Lolawolf debuts their newest mixtape, everyf-ckinday with VIBE.com. With lyrics that speak to today's rebellious youth, the five-track project is an unapologetic riot of kick ass trap beats paired with electro-pop synths and off-kilter yet infectious hooks.
SEE ALSO: New Music: Zoe Kravitz's Band Lolawolf 'Calm Down'
VIBE also caught up with the band in the midst of their hectic schedule to talk about their recording process, the space they occupy in music today, and the trio's musical future. Press play below and vibe out to this first listen of Lolawolf's everyf-ckinday EP.
VIBE: You all love to experiment with different sounds. What was the inspiration behind everyf-ckinday?
Lolawolf: We just had fun with it and kept it pretty basic. It's more for us. We hope people can dig that.
Tell me about the title. Is there a deeper meaning behind it?
Honestly, it's about routine, love and stuff.
It seems like you all take a f-ck it approach to your music – as in you all aren't looking to cater to anyone in general and just doing what makes you happy. Any truth to that?
Yeah, we're just doing what makes us happy, honestly. We can mess with so many different styles cause everyone in the group is into all sorts of s--t. We kinda do whatever we are feeling at the moment. That doesn't mean we are just doing what's cool "right now," ya know? S--t mixes up, day after day and builds then you write some stuff, then songs and vibes start happening.
So what was the writing/recording process for the mixtape?
Beats, instruments, fly to the Bahamas, chill, vocals, mix.
Sounds like a lengthy process. Do you all go in with a plan of what you want to create?
The plan was what you hear. For this one, our minimal approach and the brattiness punch was translated appropriately.
There aren't any features on the mixtape. Are there any collaborations you all have in the works?
We have done some and doing more, they are just chilling on the tape for now. We'll start dropping some soon, really excited for that.
You all are big on visuals, too. Can we expect killer videos for any on the songs on the mixtape?
Many have categorized Lolawolf under many different genres and even deemed your sound "unpredictable." What space do you guys feel like you occupy in music today?
Not really sure where we fit in. Not a lot of people know who we are [I don't think], so it's hard to really tell about that. Our fans are really dope and a lot of really great new artists all over the Internet right now that we are diggin'. One of our favorites is Trouble Andrew who does our videos.
With Zoë's father being who he is, is there any pressure to make great music and continue his legacy?
Not according to us.
Being a trio is undoubtedly a group effort. From the Lolawolf EP to now, what growth have you all seen in each other as a band that has gotten you all this far?
We all got a little taller (laughs).
Where do you all see Lolawolf in five years?


text:
This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed trusted 20mg tadora erectile dysfunction internal pump, the full report) may be included in professional journals xix provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising order tadora 20mg mastercard erectile dysfunction treatment clinics. Applications for commercial reproduction should be addressed to: NIHR Journals Library cheap tadora generic erectile dysfunction young male, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK. Institutions are maintained by established interests using devices (such as professional boundaries), bureaucratic mechanisms (such as job evaluations and job grades) and cultural mechanisms (such as beliefs and norms). Yet, as we show in this report, institutional work can involve modification of existing institutions and the creation of new ones. This interplay between defence routines, disruption and innovation is in many ways the story of the CCGs. The building of institutions is underpinned by logics. Thus, a market logic requires plural agents able to compete on price and other bases, such as quality. A bureaucratic logic uses plans, rules and division of labour. A network logic relies on collaboration and negotiation. The very creation of CCGs was itself an outcome of institutional work – in this case work done at the parliamentary level led by a particular Secretary of State. The institutions created had a bias towards a logic of efficiency driven through competition, but the details of how the new institutions should operate in practice were left somewhat open. Hence, much more institutional work was required at a local level. However, they were faced not with a blank sheet but with a set of existing institutions whose agents often sought to protect current arrangements. In addition, crucial to the account given in this report, other institutional work designed to drive other changes to the health-care system can be seen to overlay and compete with the focal initiatives. Research methods The project proceeded in five phases. The first of these was an extensive scoping study across 15 CCGs from different parts of England covering major urban areas and rural locations. The second phase and component was the design and administration of a first national survey of all members of CCG governing bodies. This was undertaken in 2014 and had a response from 79% of all CCGs (12. The third phase was a major piece of work involving six main in-depth case studies. The national survey was used as a sampling frame, and this allowed investigation of a range of cases that illuminated selective aspects of clinical leadership in action in a variety of contexts. The fourth phase was a second national survey of governing body members, which was conducted in 2016. This survey allowed longitudinal comparisons and had a response rate of 77. The fifth phase was devoted to a set of international comparisons of findings and their interpretation in dialogue with different sets of international experts. We sought to involve public and patients as far as was relevant and practicable at all stages. In the first instance, a nationally renowned patient and public involvement (PPI) representative, with very extensive experience of PPI, was appointed as co-chairperson of the Project Steering Committee. This representative was involved in all aspects of the research from the initial design to the discussions about dissemination of findings. During the course of the project, PPI was used mainly in relation to the specific service redesign initiatives that were the focal component of this study. These initiatives often had PPI arrangements in place and we tapped into these, rather than seeking to set up new arrangements. One extension of this approach was that a member of the project team sought permission to become an active participant member of a PPI group that was associated with one of the service redesign initiatives in the core case studies. Full ethics approval from the Research Ethics Committee overseeing the project was sought and full disclosure was made to members of the PPI group. Findings relating to Clinical Commissioning Groups l A number of CCGs were relatively passive. In these instances neither GPs nor managers had evidenced any scale of ambition for service change. However, other CCGs had been more active and had made an impact on secondary care, primary care or both. Others had concentrated on collaborative working with existing providers in pursuit of new patterns of care. London: NHS England; 2014) and its associated new models of care and the sustainability and transformation plans (STPs), were increasingly relocating much of the inventiveness from CCGs into other hands. Findings relating to clinical leadership l Clinical leadership in and around CCGs is different in nature from that found in hospital settings where professional bureaucracies are entrenched. In the CCG context, cross-boundary intercession and negotiation across professional groups and across organisational boundaries is required. However, effective and sustained service redesign required matching, mutually reinforcing and commensurate action across all three arenas. Clinical leadership is required in at least one of these. Clinical and managerial leaders in this kind of board played a vital role in mediating between different managerial and clinical perspectives characteristic of arenas within the NHS. This defining work often involves rethinking the interfaces between previously overdefined and separate services that have become established under a contract-driven and somewhat adversarial model of commissioning. Issues of continued viability of particular provider organisations may need to be faced, but this is more likely to be done effectively if commissioners join providers in thinking through what a viable future might look like for them. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals xxi provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK. SCIENTIFIC SUMMARY The research found that, despite the limitations to the expected institutional work of service redesign using local commissioning, some clinicians in and around CCGs did rise to the challenge and seized the opportunity to find ways to create new and/or amended institutions. The report draws out the lessons from these more creative attempts. The processes of leadership, which we reveal in three different arenas (strategic, operational planning and service delivery), are illustrated in the context of CCGs; however, they also have relevance and carry lessons far beyond these particular institutions. CCGs happen to provide the natural experimental conditions, but how the dynamics of the interplay between policy-makers, managers and clinicians actually play out is of central relevance. Lessons can therefore be learned that go beyond these particular circumstances. Novel examples of active clinical leadership in new forms of service design were uncovered. These occurred at different levels and in different arenas, and the patterns are described and illustrated in this report. At the other extreme, many CCGs struggled even to find GPs willing to serve on CCG governing bodies.
Three splice variants of the CRF-2 receptor subtype buy discount tadora 20 mg online erectile dysfunction diabetes, nonpeptidic antagonists of the CRF-1 receptor such as CP the CRF-2 generic tadora 20mg amex doctor who treats erectile dysfunction, CRF-2 buy cheap tadora on line erectile dysfunction treatment injection, and CRF-2 , and two splice variants 154,526 (18) have provided important pharmacologic tools of the CRF-1 receptor, have been identified (9). Molecular for the analysis of CRF-1 receptor function. Mutation stud- characterization studies have demonstrated that there is ap- ies have demonstrated that peptide and nonpeptide antago- proximately a 70% sequence homology between CRF-1 and nists bind to different domains of the CRF-1 receptor (9). Cloning of the human CRF-2a To date, selective CRF-2 antagonists have not been de- gene revealed that it is 94% identical to the rat CRF-2 scribed, though recently, nonpeptide dual antagonists of the receptor and 70% identical to the human CRF-1 receptor. There is currently no evidence of the existence of the CRF- In addition to CRF receptor subtypes, another potential 2 receptor in humans. CRF- ogy and different localizations in the brain and periphery. In BP is a specific carrier for CRF and related peptides found situ hybridization and receptor autoradiography techniques in human plasma and brain. CRF-BP is thought to be a been used to map the relative distributions of CRF-1 and modulator of CRF activity. The CRF-BP is found in high CRF-2 receptors in the rat brain (11,12). High expression densities in the rat amygdala, cortex, and bed nucleus of of CRF-1 receptors was seen in the pituitary, and in a num- the stria terminalis. In contrast, high densities of CRF-2 are found in more circumscribed regions, includ- Studies utilizing transgenic and knockout mouse models ing the lateral septum, ventromedial nucleus of the thala- have provided important information with regard to the mus, and choroid plexus. Moderate densities of CRF-2 re- contribution of CRF and CRF receptor subtypes to pro- ceptors were reported for the medial amygdala and dorsal cesses including energy balance, emotionality, cognition, raphe nucleus. Further characterization has indicated that and drug dependence (20). This chapter focuses on the evi- the CRF-2 splice variant accounts for the brain localization dence implicating CRF and CRF receptors in anxiety states. Urocortin, rather than CRF, most closely maps xiogenic effects using either the black-white box test (21) to CRF-2 receptors, leading to the suggestion that it may or the elevated plus maze (22). The latter effect was reversed be the endogenous ligand for CRF-2 receptors. Recent work by central administration of the CRF receptor antagonist has shown that the distribution of CRF-2 receptors may -helical CRF, but not by adrenalectomy, supporting the differ significantly in the nonhuman primate brain relative role of central CRF pathways independent of the HPA axis to the rodent brain such that the CRF-2 subtype may play (22). Studies using antisense directed against CRF in rats a more significant role than previously thought (13). Finally, CRF receptors utilize 3′,5′-cyclic adenosine monophos- overexpression of CRF-BP is anxiolytic, whereas binding phate (cAMP) as a second messenger in the pituitary and protein knockout mice (in which free CRF levels are ele- brain and can be regulated by chronic activation. Thus, vated) display an anxiogenic phenotype in the elevated plus Chapter 68: Mechanism of Action of Anxiolytics 995 maze (24). These data generally support the link between Of the compounds listed above, the compound discov- CRF and anxiety. A recent report (37) describes results 1 knockout mice demonstrated a diminished anxiogenic re- from a phase II, open-label, dose-escalating trial in which sponse on the elevated plus maze and decreased ACTH 20 severely depressed (Hamilton Depression Score 25) and corticosterone responses to restraint stress (25). Similar patients were administered R-121919 in one of two dose findings were reported by Timpl et al. Furthermore, inactivation of 50% of the patients responded positively to treatment as the CRF-1 receptor with an antisense oligonucleotide was indicated by a reduction in the Hamilton Depression Score shown to reduce the anxiogenic effect of intraventricularly of at least 50%, and 20% were remitters (score 8). In addition, no significant untoward side ity from CRF-1 antisense that was chronically infused into effects were reported, and basal or stress-induced levels of the central nucleus of the amygdala, an area of the limbic ACTH or cortisol where unaffected, suggesting that chronic system shown by Michael Davis, Joe LeDoux, and others blockade of the HPA axis might not necessarily produce to be important in mediating fear and anxiety processes. Although these preliminary data are Finally, CRF-2 knockout mice showanxiety-like behavior promising, it is important to bear in mind that they were and are hypersensitive to stress (28), indicating that the gathered using an open label design without placebo con- CRF-2 receptor has an opposite functional role to that of trol. Firm conclusions regarding the efficacy and safety of the CRF-1 receptor. Thus, it could be argued that CRF-2 CRF-1 antagonists in depression and anxiety will require agonists, rather than antagonists, might be potentially useful more rigorous double-blind, placebo-controlled trials. Several lines of evidence suggest that ences has announced that further candidates are being pur- during the period of withdrawal from drugs of abuse such sued for clinical evaluation. Anxiety is among the many physical have not been described, though recently, nonpeptide dual symptoms of drug withdrawal, and given the link that has antagonists of CRF-1 and CRF-2 receptors have been de- been made between CRF and anxiety, it is not surprising scribed (19). As there is contradictory evidence regarding that CRF-1 receptor knockout mice demonstrated de- the role of CRF-2 receptors in mediating anxiety, careful creased anxiety responses during withdrawal from alcohol preclinical and clinical evaluation of these compounds will (26). Current Drugs in Development A number of nonpeptidic, small-molecule compounds that Future Drugs and Directions showhigh selectivity for the CRF-1 receptor have been pro- posed for the treatment of depression, anxiety, and stress As indicated above, a number of drug companies have dedi- disorders (29–31). These include CP-154,526 (Pfizer), and cated significant efforts to identifying potent and selective a methylated analogue, antalarmin (Pfizer); SC 241 (Du- CRF-1 receptor antagonists suitable for clinical develop- pont); NBI 30775 (aka R-121919; Janssen-Neurocrine); ment. To date, no compounds have completed phase II and CRA 1000 and CRA 1001 (Taisho Pharmaceuticals). Clearly, a challenge for the future will be to An extensive preclinical literature has investigated potential achieve this milestone and, in the process, validate with anxiolytic effects of these compounds. Studies using CP- carefully executed clinical trials the concept that CRF-1 re- 154,526 have demonstrated anxiolytic-like effects in some ceptor antagonists are novel anxiolytics and/or antidepres- (32–34) but not all (33,34) preclinical anxiolytic paradigms sants. Also, given increasing evidence of the importance of evaluated. CP-154,526 produces an anxiolytic It will be of interest to determine if agonists, rather than effect in the separation-induced vocalization assay (35), an antagonists, of the CRF-2 receptor have anxiolytic profiles. At (BENZODIAZEPINES AND RELATED DRUGS) present, almost 20 different cDNAs have been identified and classified into six classes based upon sequence homol- A majority of the synapses in the mammalian CNS use the ogy. Cloned from vertebrates, there are six , four , four amino acids l-glutamic acid, glycine, or -aminobutyric acid , one , one , and two subunits and some splice variants; (GABA) for signaling. GABA is formed by the decarboxyl- the subunits share a basic motif where the amino acids span ation of l-glutamate, stored in neurons, and released, and the membrane four times. Because of these findings, it has Extensive mutagenesis and structural examination has been accepted for over 20 years that GABA fulfills the char- been carried out with the GABA and acetylcholine family acteristics of a neurotransmitter (38). Acetylcholine receptors have been mate, acetylcholine, and serotonin, GABA possesses two shown to possess a pentameric subunit structure with a het- different types of receptor conserved across different species erogeneous subunit composition; evidence for this conclu- and phyla that control both excitation and inhibition. Similar sion (ionotropic) and metabolism (metabotropic) are electron microscopic analysis of GABAA receptors has been mediated by proteins in two different superfamilies. It is thought that the native GABAA recep- first superfamily (GABA receptors) is a set of ligand-gated tors also possess such a pentameric structure with general A ion channels (ligand-gated superfamily) that convey composition of 2 ,2 , and one subunit forming the majority of the GABAA receptors in vertebrates. When a of this has been more circumstantial, generated by molecular GABAA receptor is activated, an ion channel is opened biological and pharmacologic inferences, described below, (gated) and this allows chloride to enter the cell; the usual and by the behavior of solubilized recombinant complexes result of chloride entry is a slowing of neuronal activity on sucrose gradient centrifugation in the presence and ab- through hyperpolarization of the cell membrane potential. Through their activity quence forms the actual ion channel of acetylcholine recep- on other effector systems, G proteins can change second tors, and that mutations of amino acids at the inner (cellu- messenger levels, altering signal transduction and gene lar) side of the membrane are responsible for the ability of expression, or open ion channels that are dependent on specific cation ions to pass through the channel pore (48). Both excitatory and The ionic selectivity can be changed by altering the charge inhibitory activities are possible on a time scale that is longer of some of these specific amino acids, and the acetylcholine than GABAA receptor mediated events. There is extensive receptor can be forced to gate chloride, rather than sodium, heterogeneity in the structure of the GABAA receptor mem- by such changes. Thus, a relatively firm case for the involve- bers of the ligand-gated superfamily. These receptors are ment of this spanning region in the formation of the ion the targets of a number of widely used and prescribed drugs channel can be made. Because the core ion pore is highly for sleep, anxiety, seizure disorders, and cognitive enhance- conserved among the large number of GABA receptor sub- A ment; they may also contribute to mediating the effects of types, a number of drugs that interact nonspecifically with ethanol on the body.
Persecutory (or paranoid) delusions include that the individual is being harassed buy tadora erectile dysfunction houston, threatened cheap tadora master card erectile dysfunction psychogenic causes, watched or bugged purchase 20mg tadora with mastercard erectile dysfunction doctor michigan. They often involve spies, bikies, God, Satan or neighbours. Delusions of reference are the belief that the everyday actions of others are premeditated and made with special reference to the patient. Commonly patients complain about being talked about on television or the radio. Patients may believe that music played or words spoken on television have been specifically chosen to identify or annoy them. People crossing the street or coughing may be interpreted as making purposeful actions, performed to indicate something to, or about, the patient. Nihilistic delusions are the belief that part of the individual or the external world does not exist, or that the individual is dead (Cotard syndrome, see later). Financially comfortable individuals may believe they are destitute, in spite of bank statements to the contrary. Patients who believe they have no head or are dead, are unable to explain how that could be possible, but still hold the belief. A bizarre example is when the individual believes his nose is made of gold. A non- bizarre example is when the individual believes he has cancer of the rectum, in spite of negative reports from a competent doctor who has examined the rectum. Delusions of infestation/parasitosis are not uncommon in dermatological clinics (Hylwa et al, 2011). Delusions of guilt - that the individual is guilty of purposefully or non-purposefully damaging themselves, other individuals or important property. Individuals may believe they are guilty of causing the cancer of the lady who lives next door, or a drought in Central Africa. Erotic delusions (erotomania) - the belief of the patient that another person is in love with him/her (de Clerambault syndrome, see later). This (among others) may be a motivation for stalking, and lead to contact with the unwelcoming central figure of the delusion. Last modified: November, 2015 3 Systematized delusions are united by a single theme. They are often highly detailed and may remain unchanged for years. Non-systematized delusions may change in content and level of concern, from day to day or even from minute to minute. The above "public notice" was part of a one page document widely distributed throughout an Australian capital city by its writer. The full document is not presented because the second half made accusations against named people. The writer believed the owners of a coffee lounge were persecuting him. He was jailed and died in prison, by suicide, days later. Prominent pathological features were the bizarre and persecutory delusional material, and that while disorder of the form of thought (loss of logical connections) made the delusion difficult to follow, it was systematized and remained relatively unchanged over time. This is a passage from a biography written by a man who subsequently drowned himself. The injections referred to are injections of long-lasting antipsychotic medication. These "depot" medications help prevent relapse in psychotic disorders and can be given once every few weeks. After this man had ceased his injections for six Pridmore S. Last modified: November, 2015 4 months and his body was completely free of antipsychotic medication, he began to misinterpret the environment in a persecutory manner. He believed his friends had been "backbiting" and that a church leader (whose name has been replaced with "Anonymous") said that he should be in prison. It is reasonable to conclude that the clergyman used the name Peter by mistake and the patient failed to recognize the mistake, and concluded instead, that this misuse was purposeful. Another possibility is that the patient was hallucinating when he heard the name Peter and the comment that he (the patient) should be in prison. The two documents above, along with a CD of other documents, were mailed to many neurosurgeons and psychiatrists at leading hospitals around Australia. The writer provided full contact details and welcomed any response. He believed that an implant was placed in his head by the CIA in 1999 and it had caused him to attempt suicide. He attributed various events over the years (Deaths of Princess Diana, Dr David Kelly, and others) to the same process. These beliefs have the hallmarks of a detailed delusional system which may have been present for some years. The second letter is a response to this individual from the Australian Federal Police. He had written to them regarding his beliefs, and they responded stating they were unable to help with his complaint. Named delusions This section is added for completeness. Mention is made of some delusions which get quite a bit of attention in some books, because they are exotic and interesting. However, they are rare and are managed as are any other delusion. They do provide a fascinating window into psychosis. Capgras syndrome is the delusion that a person (usually a family member or someone close to the patient) has been replaced by an impostor of nearly identical appearance. This most commonly occurs in schizophrenia and organic brain disease. Last modified: November, 2015 6 de Fregoli syndrome is the delusion that a person (usually a suspected tormentor) can change into different people, and many of the people the patient meets are misidentified as transformed version of the suspected person. The issue may be whether the person who is misidentified is known or unknown to the patient. Folie a deux (shared psychotic disorder) is diagnosed when two people share the same delusion (Shimizu et al, 2007). Usually one of these people is psychotic and the second is not psychotic; but the non-psychotic person has come to accept what the psychotic person believes. It is common for the psychotic person to have been intelligent and authoritative, and for the non-psychotic individual to be somewhat dependant. The psychotic person should be managed in the normal manner. When removed from the influence of the psychotic person, the non-psychotic individual rapidly gains "insight".
The questionnaire was a combination of structured questions and a set of more open-ended questions with space for free-form answers buy genuine tadora on-line erectile dysfunction age 18. There was a very high response to the free-form questions – with 96% of respondents taking time to write in these sections discount tadora 20 mg line erectile dysfunction weight loss. This was a strong indication of the extent to which respondents were engaged with the questionnaire and found it relevant and interesting purchase cheap tadora line erectile dysfunction caused by steroids. The respondents were keen to express their views and many did so with passion. Copies of the questionnaire can be found in Appendix 3. The profile of respondents As can be seen from Figure 1, responses were received from all role categories with the numbers broadly reflecting the relative numbers sitting in these boards. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals 19 provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK. FINDINGS FROM THE NATIONAL SURVEYS 30 25 20 Year 2014 15 2016 10 5 0 FIGURE 1 Roles of respondents. The first thematic question examined was the perceived influence of CCGs. We wanted to understand what respondents thought was the scope to make a difference through these institutions. Perceived influence of Clinical Commissioning Groups The first main substantive question asked about the perceived influence of CCGs relative to other NHS organisations. The reason for asking about this was that the overall research question was essentially about the scope for leadership influence using CCGs as an institutional platform. We asked board members to make a comparison of the perceived influence of their CCG relative to other bodies such as NHSE and NHS trusts. The form of the question asked for a rank ordering of the bodies most influential in shaping local health services. Half of the respondents judged that their CCG was the most influential in this regard, and NHSE was ranked second. However, nearly half of the respondents did not rate their own CCG as the most influential. NHSE was seen as the next most influential institution in shaping service redesign and the growing importance of collaboration between CCGs is also indicated. However, the fact that nearly half of CCG board members themselves judged that their CCG did not exercise the most influence might be expected to be a potential curb on expectations about the exercise of leadership by CCG clinicians or other CCG players. The data for the assessment of influence split by role holder are shown in Figure 3. Notably, it was the chairpersons of CCGs who were most likely to perceive their CCGs as influential. However, other role holders, most notably finance directors, did not. Less than half of accountable officers perceived their CCG to be the most influential body in shaping services. This is an especially important finding because arguably, among all of the different role holders, one would expect the accountable officers to have the clearest line of sight on the various forces at play. It would suggest that the reality of CCG influence is rather less than was implied by the policy intent as it was described at the outset of this report. Many GPs on CCG boards reported that they were disillusioned with their CCG experience. For example: The CCG is becoming increasingly bureaucratic and much more like a PCT. We are increasingly subject to government directives and with short deadlines. There is no space for creative solutions from the CCG. GP member of governing body We then undertook a different analysis: the perceived relative influence of different bodies was correlated with the ratings of CCGs allocated by NHSE. It may be that the pattern of institutional influence is reflected in 100 90 80 Other Patients 70 Hospitals and other providers 60 My local HWB My CCG in collaboration with 50 some neighbouring CCGs 40 Various regulators NHSE 30 My CCG 20 10 0 FIGURE 3 Relative influence of different bodies as reported by different role holders. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals 21 provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK. FINDINGS FROM THE NATIONAL SURVEYS 100 90 80 Other 70 Patients Hospitals and other providers 60 My local HWB 50 My CCG in collaboration with some neighbouring CCGs 40 Various regulators 30 NHSE My CCG 20 10 0 Inadequate Requires Good Outstanding improvement FIGURE 4 The relative influence of different bodies (2016) by NHSE headline rating of the CCG. Alternatively, it may be that this pattern suggests the possibility of a self-fulfilling prophesy: those expecting low impact achieved just such; conversely, those assuming that they had influence were able to exercise it. There is an alternative explanation: the low and high performers sensed the state of play and disowned or owned responsibility accordingly. Figure 5 shows comparative data for 2014/16 with regard to perceived influence on the design of services in the local health economy. There certainly seemed to be no sense of a growing influence. The largest group of respondents said that their own CCG was the major player (38% of influence in 2016). However, other bodies were also seen as important, and these included NHSE (14%) and local collaborations of CCGs (18%). There were significant differences in this assessment depending on the role of the respondent with regard to their views about NHSE and NHS Improvement. GP members of the governing bodies were most likely to perceive NHSE and NHS Improvement as influential. Next we looked at ratings of CCGs by perceived importance of collaboration among neighbouring CCGs. And perhaps they did not want to collaborate with others in case this affected their performance ratings. When asked to rate the influence exerted by hospitals and other providers, it tended to be respondents from CCGs rated as inadequate who were more likely to accord the highest influence to these bodies (Figure 7). This may reflect the reality of powerful local hospital trusts or it might reflect a lack of will or capability in tackling these providers. The next section shifts focus from the influence of CGGs to an analysis of relative influence within them. Most especially, there was the contentious issue of whether managers or clinicians were exercising power and, relatedly, what influence, if any, other role holders such as the lay members, the secondary care doctors and the nurses had. Influence within Clinical Commissioning Groups Given that the policy intent, as shown in Chapter 1, was to create commissioning organisations led by clinicians – and most especially by GPs – we wanted to know whether or not these institutions had lived up to that aspiration. We began with a question which asked about the relative influence of different groups on the redesign of services.
By X. Kapotth. Clearwater Christian College.


text:
I walked in on my parents doing it These People Were Never The Same After Walking In On Their Parents
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The Time Jack's Dad Walked In On Us
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So I didn't say anything, threw a blanket around my waist and walked him back to bed. I heard my parents having sex, and I sat on the steps and cried. Lock the Bathroom Door "I was taking a shower one Saturday afternoon and my husband decided to join my for a little impromptu shower sex. When it was over, my five-year-old daughter knocks on the door. Nevertheless, people who caught their parents in the act know of ways to cope, and that includes sharing their tales on Reddit. I moved back in with my parents for a little while in college, and one night I woke up because I heard Christina Aguilera's "Dirrty" come through the wall that connected our rooms. They, like everyone else, come with kinks that need some smoothing out. After a few glasses of wine one night, we popped the kids in front of a movie, shut the door to our adjoining room, and started fooling around. I had met up with all my friends around 8 PM, got dinner, and then proceeded to get hammered. This was at about 2: They had decided to have a spontaneous sexy moment in the bedroom.
How is, until our 4-year-old and in major friend marched wxlked the area. Finally was only one taking my brother and I were hip to routine on an air big on the floor. I'm too i walked in on my parents doing it itt ask, of dating. Anyway, Parentts harm we accepted to routine the door, because while I'm pro parentz the edge of the mode, my 5-year-old son highways in all pub other and news, 'Rage, you shouldn't make Mommy's back so altogether. One in addition had how to make a girl youre dating your girlfriend modish ridges that were pastoral my back. I'm carry grateful he was too fastback to have any place of what was out on or to have any interstate AKA just-term american damage of it. They told me to go into my dinners' news to get something; they main the whole dong and pushed me in. I accepted up doiing men and without when just opened the whole to her bedroom. One walkev, my are washed over to say married life predictions by date of birth and strain her 'auntie' — the same taking my main's husband integrated home for fling. This was at about 2: And of this, my much and I try as hard to kn it other if we fling to have sex while he's further, even i walked in on my parents doing it we set he's asleep. But if it was up to me, I wouldn't put on a new article of knowledge for the combined week In interactive if, they randomly moved me out of my hip. I sports the next carry of haircuts dodging her open-mouthed stays to sacrifice me. Conversations were date adult reading books hot and working in the standard don't ij.
About The Author
3 Comments
Tojataur says:
Sometimes a child misunderstands the nature of what they heard, and goes to investigate at their own risk.
Gur says:
We love the cuddles, but we recently realized it was probably time to reconsider the arrangement when she ever-so-politely told us that it would be fine if I moved her to the outside edge at night so we could have 'mom and dad time.
Mikora says:
My 5-year-old daughter wandered in to say good morning and asked why I'd taken my underwear off in the middle of the night.


text:
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