text:
{{ item.quantity }}
Total item
Recently added item(s)
Remove Item
Your cart is currently empty.
Recently added item(s)
Your cart is currently empty.
Recently added item(s)
Your cart is currently empty.
Recently added item(s)
Your cart is currently empty.
In Stock Out of stock
Style: Europe
Classification: Window Stickers,For Wall,For Tile,Furniture Stickers
Model Number: 6970085182691
Specification: Single-piece Package
Brand Name: SHIJUEHEZI
Scenarios: Wall
Theme: Portrait
Material: PVC
Censor Code: A-6970085182691
Pattern: Plane Wall Sticker
Commodity size: about 50*70cm (19*27 inch) Wall Sticker
Reference size on the wall: about W132*H88cm Wall Sticker
Size: Large Size Wall Sticker
Feature: Removable / Durable / Waterproof / Self-adhesive
Transport Package: Carton Box or Foam Rod
Color : Multi Color Wall Sticker
Content: Creative Beautiful Girl, Bubbles, Butterfly Stickers
Tracking Information: Available
Delivery Time: The more quickly you pay, the faster you receive
Sales Promotion: Seller Discount / Coupons
Fairy Girl Bubbles Wall Sticker Vinyl Butterflies Wall Art DIY Home Decor for Kids Rooms Living Room Decoration
About Us{"en":"About Us","fr":"À propos de nous"}
Store informationWe are a global store. Bringing you the best offers online, the best quality and reviews. Shop with confidence. Please allow sufficient time for shipping.
We'll email only for really big sales{"en":"We'll email only for really big sales","fr":"Une courte phrase décrivant, vous recevrez en vous souscrivant"}
Regular price
|{{ item.title}}
{{ getTextTransByKey('products.product.in_stock') }} {{ getTextTransByKey('products.product.out_of_stock') }}


text:
Learn more about Scribd Membership
Discover everything Scribd has to offer, including books and audiobooks from major publishers.
October 2010
0 Table of Contents
Overview of FinCorp 2 Mission Statement 3 Affiliation 4 Range of Services 5 Experience of FinCorp Professionals 20 Management & Staff 26 Contact us 30
This corporate profile serves as a reference for the investment community and other interested parties. It provides an introduction toFinCorp and offers a simple yet comprehensive handbook of relevant information to assist anyone wishing to analyze us. us
1 Overview of FinCorp FinCorp ultimately depends on maintaining long termclient relationships through these 4 key values that act in a FinCorp continuous circle. ¾ A fully licensed Investment Banking firm that was Long Term originally established in Egypt in 1998 with a Client paid-up capital of LE 20 million. Relationships ¾ FinCorp is owned and managed by a group of highly qualified professionals with excellent track record in Corporate Finance and Asset Management. Professionalism ¾ FinCorp operates on a regional basis through a network of sister companies located in the following important locations: Quality output Cairo Riyadh y Doha Dammam Innovation ¾ We also have strategic alliance with financial advisory firms in Jordan, Lebanon, Syria, Yemen, Specific p Tailoring g Libya, y , Algeria, g , Sudan,, and France.
2 Mission Statement
3 Affiliation• Egyptian Financial Supervisory Authority (EFSA) www.efsa.gov.eg FinCorp Investment Holding (S.A.E.) is registered with EFSA and is authorized to provide the following integrated investment banking services: ¾ Financial advisory services ¾ P Promotion i andd underwriting d ii ¾ Portfolio Management ¾ Venture Capital ¾ s ab s g new Establishing ew co companies pa es
4 Range of Services
I t Investmentt Banking
5 Financial Advisory Services
Business us ess Valuation
Financial and Corporate Restructuring
Strategic Feasibility Business B i Planning Studies
6Range g of Services……
7Mergers, g Acquisitions q & Disposals…………… p
8Range g of Services……
Conducting technical, financial and economic studies to determine the fair market value of fixed assets owned by the enterprise using internationally recognized valuation standards. Preparing necessary accounting and financial studies to revaluate other assets and liabilities. liabilities Prepare an accounting and financial report to reflect the results of the revaluation of the enterprise and illustrating the fair value of the enterprises equity. Obtainingg ppartners approval pp on the results of the valuation p process. Submit a request to the Ministry of Trade, and other official bodies, to convert the enterprise to a limited liability or a Joint Stock company after meeting all required conditions. Take necessary steps to list the new company upon obtaining the approval from relevant G Governmentt authorities. th iti
9 Range g of Services……
3. Business Valuation FinCorp provides valuation services for a broad range of purposes, including: Business sales, purchases, and mergers Corporate planning and strategic alternative agreements Cross Cross-fund fund investments for venture capital and private equity investors Dispute resolution, litigation support, and expert opinions and testimony Equity placements and financings Intellectual property/intangible asset valuations Management compensation and stock-option programs Portfolio valuation and strategic alternative assessment for venture capital and private equity investors Recapitalizations, restructurings, stock repurchase, and spin-offs
V l ti services Valuation i id d for are provided f M&A transactions t ti i which in hi h FinCorp Fi C h been has b th investment the i t t banker as well for transactions (both buy-side and sell-side) where we have structured the deal.
FinCorp has extensive experience working with shareholders, stakeholders, boards of directors, and other interested parties with valuations, valuations appraisals and fairness opinions. opinions
10 Range g of Services……
4. Feasibility Studies
Studying different aspects of the project and analyzing its strengths and weaknesses through the following: Supervise the preparation of detailed marketing studies / market research to identify marketing k ti opportunities t iti available il bl for f the th project. j t Supervise the preparation of technical and engineering studies required to estimate the project's investment cost. Conduct a financial appraisal for the project to identify its key financial indicators. Estimate the project's Internal Rate of Return (IRR). Conduct necessary sensitivity analyses to assess the project's sensitivity to changes in key assumption used for financial projections.
Identify risks associated with the project (whether related to market, operations, management or finance) in addition to assessing how such risks could be mitigated. Advise clients on possible methods to finance their projects and estimate the expected returns using different methods of financing.
11 Range g of Services……
Perform diagnostic analysis to identify company's major areas of strengths and weaknesses especially with regard to the organizational, managerial, financial, marketing and technical aspects. Perform external analysis to identify prevailing market conditions, projected trends and identify major opportunities and threats. threats Establish the company's mission statement and corporate values. Identify and agree with the management the company's strategic objectives and directions over the coming period. Identify and evaluate available options to achieve the company's strategic objectives. Recommend the option which achieve the best results Prepare an Implementation Action Plan (which includes the steps and procedures, that has to be f ll followed d to achieve hi the ' strategic h company's i goals, l ini addition ddi i to identifying id if i who h is i responsible ibl for f implementation, target competition date, success criteria and additional human and financial resources required). Assist in the Implementation of the Action Plan.
12 Range of Services……
6. Structured Finance Define the projects' short, medium and long term financing needs. Measure the projects expected level of cash flows under different operational conditions. Determine the most suitable financial instruments that could be used and the financial institutions that could be approached in order to raise the finance which conforms to and matches the project project'ss conditions (In accordance with Islamic Sharia). Identify the guarantees and collaterals that could be submitted to those financial institutions willing to finance the project. P Prepare a complete l t Credit C dit file fil (which ( hi h includes i l d all ll technical, t h i l marketing k ti andd financial fi i l studies t di ini addition dditi tot other documents pertinent to the project) and have it submitted to chosen financial institutions. Approach financial institutions to raise the required finance. Prepare p and conduct necessaryy ppresentations to selected financial institutions to highlight g g the pproject's j major areas of strengths, opportunities and risks and assess the project's expected returns in addition to providing necessary clarifications as may be needed. Evaluate offers received from different financial institutions and participate with the client's management in the negotiations with them to obtain the best financing terms. Participate in reviewing the contracts with such financial institutions.
13 Range g of Services……
Conduct detailed analysis of the different financial, marketing, technical, managerial and legal aspects that led to the company's delinquency. Evaluate the company p y and its surplus p assets usingg internationallyy recognized g valuation standards Prepare detailed cash flow projections to identify the expected performance of the company. Identify possible options for restructuring the company. Negotiate with financial institutions and creditors with the purpose of restructuring the outstanding debts. Cooperate with the company's legal advisor in drafting the restructuring agreement before it is signed by the client. Provide periodical consultancy to the client and follow-up his performance until full settlement of the outstanding liabilities.
14 Range g of Services……
Supervise the preparation of necessary financial, marketing, managerial, technical and legal studies to identify the company's major areas of strengths and weaknesses as well as the identifying major opportunities and threats. Conduct necessary financial projections to determine the company's expected cash flows and to determine the fair market value of the company and its shares using different valuation methods. For corporate Bonds: we assess the ability of the company to meet its long-term obligations and ensure that it meets the minimum requirements to obtain an acceptable credit rating. Assess the prevailing economic clients and prevailing market conditions to identify the right time for the offering. Assist in finalizing all formal requirements needed for the planned offering and in obtaining all governmentt approvalsl required. i d
15 Range of Services……
Raising money, be it debt or equity, is the life-blood of any growing enterprise. At the same time, accessingthe capital markets has never been more challenging. Many early-stage companies attempt to raise capitalwithout professional support. Increasingly, however, an expert financial advisor can make the differencebetween success and failure in closing a round. FinCorp assists clients in: developing capital strategy, drafting marketing and pitch materials, t targeting ti andd approaching hi potential t ti l investors, i t managing the due diligence process, negotiating terms sheets and long-form legal documents, and driving to the successful close of the transaction.
FinCorp helps companies tell their stories in a manner which is compelling. In a tight capital marketsenvironment, optimal messaging and positioning of a business are essential. The FinCorp approach tofundraising is disciplined, process-oriented and, most importantly, proven.
16 Range g of Services……
We offer two distinct mandates to clients, both of which benefit from access to research supplied by various securitieshouses; Long-Term Portfolio mandate The Long-Term Portfolio provides exposure to local equity, bonds and cash. This investment approach is best suited to investors seeking performance in the long term through a more conservative portfolio management style. Our investment philosophy focuses on assessing and reassessing recognized market leaders, leaders and identifying the growth shares of tomorrow. We encourage open and honest debate throughout the investment process. Diversification in these portfolios helps to reduce the threat of increased volatility seen in the local market and better absorbs any shocks that may occur, providing a level of investment consistency.
Opportunities O i i Portfolio P f li Mandate M d The Opportunities Portfolio provides the opportunity of enhanced returns by focusing on sectors showing out- performance or turnaround potential and identifying the growth stocks in these sectors. We actively manage portfolios to exploit anomalies and opportunities that exist in the market. The fundamental attraction of this portfolio is our ability to identify themes in the market and purchase growth stocks to maximize returns. returns The portfolio is ideally suited for risk tolerant investors looking for enhanced returns through a highly flexible portfolio. These mandates are controlled by an investment committee, which focuses on stock selection through the use of macro research and fundamental analysis, such as frequent company contact. Our investment process has evolved with the market, enabling us to identify current themes, actively seeking opportunities in the market which allow our portfolios to out-perform over the medium to long term.
18 Experience of FinCorp Professionals
19 Experience p of FinCorp p Professionals….
Galva Metal Egyptian Intl. Co. for Aluminum Egyptian Italian Paints Co.-EuroquarzoValuation study to invite potential investors to (EIPAL) A feasibility study for the tiles production Company toparticipatep p in the sale of the company's p . p y share capital ppromote a stake of the company's p y shares amongg potential p Prepared a valuation study and financial restructuring upon investors and to assist the company in securing necessary the request of the company's lenders (banks). bank loans and facilities.Valuation by Valuation by Feasibility study byFincorp Investment Holding Fincorp Investment Holding Fincorp Investment Holding
20 Experience p of FinCorp p Professionals….
Tulipp Nile & Golf Hotel ((Luxor)) Bonita for Touristic Invest., Fayed y Nile Hilton Valuation study to offer share capital for sale to potential Valuation study to determine the share value of theFeasibility study providing prospective investors with anoverview on the investment opportunity in the Golf City investors. hotel.Project. The feasibility study includes the establishment oftwo hotels, shopping complex and other facilities. Valuation byPrepared by Fincorp Investment HoldingFincorp Investment Holding Valuation Study by Fincorp Investment Holding
21 Experience p of FinCorp p Professionals….
Commercial Intl Real Estate Co. German Industry Co. (GIC) Saudi Egyptian Co. (CAT) (CIRD) A feasibility study to raise a long term loan of US$ 2.6 Feasibility study for establishing a trading company in Egypt The offering of a private placement of a capital million that will be used to finance part of the for the purpose of importing and selling footwear and other increase of US$ 14.8 million representing 25% of its construction cost of The German Chamber Tower which accessories mainly under the brand name of CAT. share capital to finance the establishment of Nile would be occupied by the Gateway Office Complex, CIRD's first project. In German Arab Chamber of Industry and Commerce addition to seeking a bank loan of US$ 29.3 million (GACIC), selected German, European and Egyptian Feasibility study by organizations Fincorp Investment Holding Valuation by Fincorp Investment Holding Valuation by Fincorp Investment Holding
22 Experience of FinCorp Professionals….
Egyptian gyp American Bank National Societe General Egyptian gypt a Commercial Co e c a Bank aTotal Assets Amounted to: L.E. 6268 Million as at Dec. 31st Total Assets Amounted to: L.E. 5474 Million as at Dec. 31st Total Assets Amounted to: L.E. 2058 Million as at Dec.2000 2000 31st 2000Total Equity Amounted to: L.E. 525 Million as at Dec. 31st Total Equity Amounted to: L.E. 473 Million as at Dec. 31st Total Equity Amounted to: L.E. 191 Million as at Dec.2000 2000 31st 2000Bank Valuation by Bank Valuation by Bank Valuation byFincorp's professionals Fincorp's professionals p p Fincorp's professionals
23 FinCorp's Most Important Asset … People
FinCorp'sFinCorp s Experienced Executives and Staff:9 Provide better understanding of current issues and high quality advice.
9 Have strong relationships with numerous leading private & public sector bodies.
24 Management a age e t & Sta Staff
Name : Mohamed Hamdy Salem Name : Mohamed El Sharnouby Abdel Aziz Ahmed
Qualifications : Bachelor of Commerce, Accounting, 1967, Cairo University, Qualifications : Bachelor of Commerce, Alexandria University. Post Graduate Studies in Economics, Financial Planning and Mgmt Accounting, McGill University, Montreal, Canada Experience : * General Manager Board Member of Banque Misr 2000/2002. Member of the Institute of Mgmt Consultants, USA * Board Member of Cairo and Alexandria Stock ExchangeExperience : Mr. Salem joined FinCorp in January 2000 as Managing 1997/2000. Director and CEO. Previously Mr.. Salem was Head of * Board Member of Extracted Oils Co. 1998 - to date. KPMG Hazem Hassan's Corporate Finance practice as well as coordinator of KPMG's Corporate Finance network in * Board Member of Delta Fertilizers and Chemical Industries the Middle East, and has accumulated over 16 years of Company 1999 – to date. experience in Senior Corporate Finance positions. Mr.. Salem has worked and lived in both Canada and Egypt. He * Chairman and C.E.O. of Misr Exchange Co. (an affiliate has gained a wide range of financial expertise in mergers company off B Banque Misr). Mi ) and acquisitions, private placements and fund raising, business * Participated in the privatization of the first company in Egypt in valuation, financial restructuring, privatisation, feasibility studies and project appraisal, corporate restructuring and strategic planning. 1993: Misr Chemicals Co. * Participated in most of the privatization processes of the public Mr. Salem directed, coordinated, led and conducted a multitude of sector companies (Food industries – Chemicals – Engineering – assignments, comprising of multi-disciplinary teams of Metallurgical). professionals in many sectors in Egypt, Egypt several Arab countries and Africa such as : banking, capital markets, tourism, manufacturing, real estate and construction.
25 Management & StaffName Fahad Abdullah AlKassim Name : Dr. Mohsen Salamony
P itiPosition E Executive ti President, P id t Al Kassim K i Position : Vice President
Qualifications Bachelor of Commerce, Accounting, 1986, King Saud Qualifications : Bachelor of Commerce, Major: Accounting, Faculty of University - Ryadah Commerce, Cairo University, Ph.D. in Investment Banking, Expert in GCC Commercial Arbitration Center London. Chairman of Al Nokhba Recruiting Experience : Dr. Salamony joined FinCorp in December 2003 as a Vice President. In addition, Dr. Salamony is currently theExperiance Mr. AL-kassim is currently the president of Al-Kassim Managing Director of IBG International Brokerage Group Consultants. Mr. Al-kassim joined Al-kassim Consultants in in Cairo. He has gained wide experience in the area of January 2001 as a senior partner. capital market development, corporate finance, and financial advisory services through his past work experience that Mr. Al-kassim started his professional career in Al-Rashed audit spans p a total of 29 yyears.He has acted as a Senior Vice firm, then moved to Al-Grid and partners audit firm (Delloite & President, in the Saudi Finance Banking Corporation in Touche). Geneva , and in Chase Manhattan Bank., preceded by his employment at the Bank of Oman in the posts of Assistant Mr.Al-Kassim established his own audit firm in 1990, and then Chief Manger and Deputy General Manager- Investment he became the Managing Director of Dallah hospital. In 1995, Banking respectively. he joined KPMG – Ryadah office as a Senior Partner and then he jjoined El Othim Commercial Groupp in 2000 as the ggroup's p General Manager. During his career Mr. Al_kassim has acquired a wide experience in different aspects such as: finance, investment, managerial and financial consultancy in addition to promotion of commercial opportunities.
26 Management g & Staff
27 Management g & Staff Name : Rania Abdallah Said Name : Khaled M. El Jaouni
Qualifications : Masters in Economics, American University in Cairo, Jan. 1991. Qualifications : Bachelor of Arts, Major Economics, American Bachelor Degree in Economics & Political Science, Cairo University in Cairo, 1993; Higher Diploma in University, 1986 Investment Management, American University Experience : Senior Consultant at Makary Consulting (March 1999- August in Cairo, 1997. Currently enrolled in MBA Programme, 2005)) Sheffield Hallam University. y Senior Financial and Economic Analyst (Free Lance), Assistant Dr. Samir Makary, Consultant & Professor of Economics at AUC Experience : Mr.. Jaouni joined FinCorp in February 2001 in the Corporate (March 1995-To Feb. 1999) Finance department. Previously Mr. Jaouni was employed Assistant and fellow at the American University in Cairo (AUC) for in KPMG Hazem Hassan Management Consultants in the graduate courses in econometrics and mathematical economics Corporate Finance department and was involved in a wide (January 1989-January 91) range of consulting assignments covering corporate Financial and Economic Analyst at the Arab International valuation, debt and equity finance, financial restructuring Consultant (ARICON), (July 1987- August 89) and financial feasibility studies. Mr.. Jaouni has over seven Assistant to Dr. Nader Fergany at the National Population Council years experience in the above fields and his area of expertise (NPC) (July 1986-June 87) extends to different service and industrial sectors, such as Mrs. Said has been involved in the consultation business with financial institutions, tourism and hotels, real estate and special reference to market and financial analysis and economic various i i d industries. i policy issues since 1986. During the whole period she handled more than 150 studies for almost all sectors and sub sectors in Egypt including tourism, textile, processed food, engineering, chemical, pharmaceutical, construction, housing, and agriculture. Mrs. Said has joined FinCorp since Dec. 2005.
28 For anyy inquiry q y pplease contact us:
M ili Address: Mailing Add Mailing Address: M ili Address: Mailing Add Mailing Address: 71, Musadak St., P. O. Box 1927 P. O. Box 47324 Office No. 408 Fifth Floor Dammam 31441 Doha Omam Builidng Dokki, Giza Salah Aldeen Alaeoby St., Saudi Arabia Qatar Egypt (Alseten) Al-Malaz District Saudi Arabia Telephones and Facsimile Telephones and Facsimile Telephones and Facsimile i i Telephones and Facsimile T l 00 974 431 31 20 Tel.: Tel.: 00 966 3 809 77 99 Tel.: 00 202 749 57 57 (10 lines) Tel.: 00 966 1 291 – 1000 Fax: 00 974 431 31 80 Fax.: 00 966 3 809 11 78 Fax.: 00 202 335 8978 Fax.: 00 966 1 291 – 1110 E-Mail E-Mail E-Mail E-Mail email@example.com firstname.lastname@example.com email@example.com email@example.com

subset: commoncrawl


text:
Cyprus buys Israeli drones amid tensions with TurkeyCyprus acquires four Israeli drone aircraft to patrol island's waters during searches for natural gas, amid tensions with Turkey.
Trial begins for British woman who accused Israelis of gang rapeBritish teen accused of making false rape complaint against 12 Israelis heads to court as trial begins Wednesday.
3 Iranians attempting to fly to UK with fake passports arrestedCypriot authorities arrest 3 Iranian nationals who attempted to travel to UK using fake Czech passports.
Herzog: Cyprus has 'vested interest' in fighting terrorJewish Agency Chairman Herzog meets with Cyprus President at Diaspora Conference.
British teen pleads not guilty in Cyprus rape claim trial19-year-old British tourist suspected of falsely accusing 12 Israeli teens of gang rape released on bail after entering plea of not guilty.
Family of UK 'false rape' teen launches GoFundMe for legal aidAfter British teen's lawyer quits, her family requests money for her legal expenses on GoFundMe. 'We just want to bring her home.'
Lawyer of British teen who accused Israelis of rape quitsTrial of 19-year-old British woman charged with falsely accusing 12 Israelis of gang rape postponed after her lawyer quits.
UK teen in Cyprus rape case: Police forced me to confessNew twist in Cyprus rape case: 19-year-old British teen who accused 12 Israelis of gang rape now says she was forced to sign confession.
UK woman who accused Israelis of rape in Cyprus indicted19-year-old British woman who made false accusation of gang rape could face jail time for 'public mischief' charges in Cyprus
Israeli teens falsely accused of rape to sue British touristAfter accuser recants claims of gang rape, Israeli teens plan to sue British teen and seek compensation from insurance company.
UK woman to be indicted after admitting she faked rape claims19-year-old British woman explains motive for falsely accusing Israeli teens of gang rape, faces indictment Monday.
All Israeli youths detained in Cyprus released7 Israelis who remained in detention over weekend released. British teen who accused them faces court on suspicion of making false claim.
All Israelis held over Cyprus 'gang rape' claims to be releasedLawyer for 7 Israeli teens held on accusations of gang rape in Cyprus says all of them to be released after accuser changed her story.
Israeli teens arrested in Cyprus gang rape case return to Israel5 Israeli youths freed after week under arrest in connection with sexual assault of British woman begin to return to Israel.
Cyprus holds 12 Israelis over alleged gang rape of UK teenIsraeli teenagers remanded by Cyprus court after being accused of raping 19-year-old British woman at hotel in resort town.
Suspected stray Syrian missile crashes in CyprusUnidentified object - possibly a stray Syrian surface-to-air missile fired during Israeli airstrikes on Damascus - lands in Cyprus.
Watch: Israel Air Force and elite 'Egoz' unit in CyprusIAF forces and commando unit take part in special join Cypriot military for special training exercise featuring remotely piloted aircraft.
Planes from Cyprus help extinguish fires in IsraelDelegation from Cyprus including firefighting planes lands at Tel-Nof Base.
Smoke causes El Al flight to divert to CyprusEl Al plane making its way to Vienna lands in Larnaca due to the smell of smoke on board the plane.
An open letter to Rashida TlaibWere the long-suffering survivors of the Holocaust exploiters? Congresswoman Rashida Tliab thinks so. The question is how many unknowledgeable people she will convince.
Regional summit with US Secretary of StateMike Pompeo attends for the first time summit between Netanyahu, Cyprus President and Greek Prime Minister.
Rivlin hosts Greek and Cypriot delegation on diaspora relationsDelegation seeks to learn from Israel's ties with diaspora Jewry about how to strengthen relations with the Greek and Cypriot diasporas.
Rivlin marks 70th anniversary of last Jewish camps in CyprusPresident flies to Cyprus to mark 70 years since the closure of British detention camps for Jews, holding talks with Cyprus president.
Ambassador Friedman lauds Israeli gas pipeline to EuropeUS Ambassador hails trilateral cooperation between Israel, Greece, and Cyprus, including development of gas pipeline.
Cyprus bills Jews $6,000 for Hanukkah events' security costsEuropean Jewish Association calls bill charging local Jews for police protection 'a new low' and 'an insult', demands bill be cancelled.
Israel, Greece, Cyprus plan underwater gas pipelineNetanyahu meets with Greek, Cypriot foreign ministers as three countries plan gas pipeline to Europe
Report: Israel-Hamas agreement to include sea route to CyprusIsrael-Hamas agreement will include sea route to Cyprus, and Qatar will pay Hamas' salaries, report says.
Cyprus mulls Israeli request of port for GazaMediterranean nation considers Avigdor Liberman's request host port for inspection and delivery of goods to Gaza Strip.
Will Israel build a naval dock for Gazans?Report says Liberman promoting construction of floating dock in Cyprus that will receive goods intended for Gaza.
Cyprus, Greece and Israel aim for gas pipeline deal this year3 Mediterranean nations seek to reach energy agreement soon.
US destroyer nears Syria as Trump promises forceful responseUSS Donald Cook leaves Cyprus port, could now launch Tomahawk cruise missiles against Syrian targets if ordered.
Organ trafficking suspect to face Cyprus extradition hearingCyprus court orders extradition of organ-trafficking suspect to begin late in February.
Cyprus denies bail for Israeli organ trafficking suspectCyprus orders organ trafficking mastermind to remain in custody until extradition process begins next month.
Kosovo requests extradition of Israeli 'organ trafficker'Kosova requests Cyprus extradite Israeli suspected of organizing organ trafficking gang.
Syrian baby to undergo operation in IsraelCyprus, Israel, work together to fly two-day-old son of Syrian refugees living in Cyprus to Israel for complex heart surgery.
Watch: IDF forces 'capture' CyprusIDF conducts 'unusual' major joint training exercise with Cypriot army forces.
Four-way agreement to build gas pipeline signedCyprus, Greece, Italy and Israel sign memorandum of understanding to build major gas pipeline.
Turks celebrate 1964 napalm bombing of CyprusCyprus is Turkish, after all. Turks can do whatever they want there. They can even celebrate dropping napalm on Greeks and slaughtering them.
Watch: Israeli commandos train in Cyprus500 IDF special forces soldiers conduct joint training exercises with air units, local army units in Cyprus.
EU nations, Israel eye world's longest undersea gas pipelineMediterranean, European countries see new gas pipeline as way to boost cooperation and boost supply.
'Cyprus deal could speed up Turkey energy project'New ambassador to Turkey says sending gas via Cyprus would speed Israel-Turkey gas project.
'We have initiated a tradition of cooperation and friendship'Knesset Speaker holds trilateral meeting with parliamentary leaders of Greece and Cyprus. Agreement reached on regional cooperation.
Free speech in Turkey? As long as you are willing to bear the resultsTurkish fashion designer beaten by mob, arrested by police over social media posts.
Israel, Greece and Cyprus agree to cooperate on wildfiresIsrael, Greece and Cyprus have agreed to fight wildfires together, as well as cooperating on natural gas production.
'My baby is alive thanks to Israel'British couple living Cyprus make horrifying discovery, rush to Israel to save 3-week old baby.
Liberman hails 'best chapter' ever of Israel-Cyprus relations"Despite all political problems and security problems in our region, we are two small democracies and very, very reliable friends."
Israel and Cyprus to increase cooperationNetanyahu meets Cypriot President and the two agree to increase cooperation in the fight against terror and natural gas infrastructures.
Israel sends firefighting planes to help douse Cyprus blazeNetanyahu orders firefighting planes to assist, following request from Cypriot government.
Cyprus approves extradition of EgyptAir hijackerCyprus says it approved a request from Cairo to extradite the man accused of hijacking an EgyptAir plane last week.
Egyptian hijacker bragged about killing IDF soldiersSeif Eldin Mustafa, who hijacked plane to Cyprus, used to brag about killing 3 IDF soldiers and fanatically supported PLO, ex-wife claims.
Egypt asks Cyprus to extradite plane hijackerEgypt asks Cyprus to extradite the man who hijacked an EgyptAir flight in order to meet his ex-wife.
Egyptian plane hijacker arrested with no casualtiesMan with explosive vest hijacks EgyptAir plane, takes it to Cyprus in effort to reunite with ex-wife. Police arrest hijacker, no one harmed.
Ya'alon warns: Iran operating 'sleeper cells' in EuropeIn Cyprus, Defense Minister warns that Iran is building an international terror network and plans attacks on the United States and Europe.
Israel, Cyprus and Greece forge ahead with Europe gas pipelineCyprus and Greece emerging as key allies, as Israel looks towards potentially lucrative pipeline - Turkey, or no Turkey.
PA Sources: Cyprus Initiating Resumption of Peace TalksCyprus pushing an initiative to revive the peace process between the PA and Israel, say Palestinian sources.
Netanyahu Warns Cyprus: Iran's Hezbollah Threatens EuropeWhile on official visit to Cyprus where Hezbollah attack was recently thwarted, PM notes group's network 'in every country in Europe.'
Cyprus Sentences Hezbollah Member to 6 YearsLebanese man given six years in jail by a Cyprus court after 8.2 tons of potential bomb-making material were found in his home.


text:
Mike Lombardi gives scouting report on Patriots heading into season, which includes high praise for defense
Mike Lombardi knows a thing or two about the Patriots, as the former New England executive is still very close to Bill Belichick.
Appearing on VSIN's "A Number's Game" Thursday, Lombardi gave an outlook for the Patriots this coming season, which included some high praise for the defense.
"I think they are better on defense," he said. "I think New England is better on defense this year. I think Jamie Collins wanted to come back to New England. He wanted to play. I think he will make them a better team and allow (Dont'a) Hightower to play more on the edge, which is what he's more suited for than playing in base. Then, there's Kyle Van Noy. I think Michael Bennett still has some gas left in the tank, so I do think they will be better on defense. I think the guy that is coaching the defense is a Hall of Fame defensive coach — forget the fact that he's a Hall of Fame head coach. I do think they will be better.
"The question will be can they get this offense changed to where — it changed last year. Everybody talks about Gronk coming back, they were not a tight end oriented offense last year, partly because the two best tight ends blocked — Gronk and Dwayne Allen. That helped their running game, so they utilized their skillset. When everybody zigs, Bill Belichick zags. When everyone is in spread, he's in two backs. I think that is where he gains an advantage."
New England finished the 2018 regular season ranked 21st overall on defense, but only allowed 20.3 points per game, which were tied for sixth in the league.
The Patriots will open training camp next Thursday.
ICYMI on #ANumbersGame w/ @beatingthebook. @mlombardiNFL looks ahead at this season for the #Patriots pic.twitter.com/IZBgm6JU0w— VSiN (@VSiNLive) July 18, 2019
Related: Nick Caserio reportedly not only Patriots front office member in contract year


text:
Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.
Hu X, Compton JR, Leary DH, Olson MA, Lee MS, Cheung J, Ye W, Ferrer M, Southall N, Jadhav A, Morazzani EM, Glass PJ, Marugan J, Legler PM
Biochemistry , (55), 3007-19, 2016.
Article Pubmed
The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine protease (EC 3.4.22.-) is essential for viral replication and is involved in the cytopathic effects (CPE) of the virus. The VEEV nsP2 protease is a member of MEROPS Clan CN and characteristically contains a papain-like protease linked to an S-adenosyl-l-methionine-dependent RNA methyltransferase (SAM MTase) domain. The protease contains an alternative active site motif, (475)NVCWAK(480), which differs from papain's (CGS(25)CWAFS), and the enzyme lacks a transition state-stabilizing residue homologous to Gln-19 in papain. To understand the roles of conserved residues in catalysis, we determined the structure of the free enzyme and the first structure of an inhibitor-bound alphaviral protease. The peptide-like E64d inhibitor was found to bind beneath a β-hairpin at the interface of the SAM MTase and protease domains. His-546 adopted a conformation that differed from that found in the free enzyme; one or both of the conformers may assist in leaving group departure of either the amine or Cys thiolate during the catalytic cycle. Interestingly, E64c (200 μM), the carboxylic acid form of the E64d ester, did not inhibit the nsP2 protease. To identify key residues involved in substrate binding, a number of mutants were analyzed. Mutation of the motif residue, N475A, led to a 24-fold reduction in kcat/Km, and the conformation of this residue did not change after inhibition. N475 forms a hydrogen bond with R662 in the SAM MTase domain, and the R662A and R662K mutations both led to 16-fold decreases in kcat/Km. N475 forms the base of the P1 binding site and likely orients the substrate for nucleophilic attack or plays a role in product release. An Asn homologous to N475 is similarly found in coronaviral papain-like proteases (PLpro) of the Severe Acute Respiratory Syndrome (SARS) virus and Middle East Respiratory Syndrome (MERS) virus. Mutation of another motif residue, K480A, led to a 9-fold decrease in kcat and kcat/Km. K480 likely enhances the nucleophilicity of the Cys. Consistent with our substrate-bound models, the SAM MTase domain K706A mutation increased Km 4.5-fold to 500 μM. Within the β-hairpin, the N545A mutation slightly but not significantly increased kcat and Km. The structures and identified active site residues may facilitate the discovery of protease inhibitors with antiviral activity.
A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration.
Liao XH, Meena NP, Southall N, Liu L, Swaroop M, Zhang AL, Xiang JJ, Parent CA, Zheng W, Kimmel AR
Sci Rep , (6), 22273, 2016.
Article Pubmed
Chemotaxis and cell migration are fundamental, universal eukaryotic processes essential for biological functions such as embryogenesis, immunity, cell renewal, and wound healing, as well as for pathogenesis of many diseases including cancer metastasis and chronic inflammation. To identify novel chemotaxis inhibitors as probes for mechanistic studies and leads for development of new therapeutics, we developed a unique, unbiased phenotypic chemotaxis-dependent Dictyostelium aggregation assay for high-throughput screening using rapid, laser-scanning cytometry. Under defined conditions, individual Dictyostelium secrete chemoattractants, migrate, and aggregate. Chemotaxis is quantified by laser-scanning cytometry with a GFP marker expressed only in cells after chemotaxis/multi-cell aggregation. We applied the assay to screen 1,280 known compounds in a 1536-well plate format and identified two chemotaxis inhibitors. The chemotaxis inhibitory activities of both compounds were confirmed in both Dictyostelium and in human neutrophils in a directed EZ-TAXIscan chemotaxis assay. The compounds were also shown to inhibit migration of two human cancer cell lines in monolayer scratch assays. This test screen demonstrated that the miniaturized assay is extremely suited for high-throughput screening of very large libraries of small molecules to identify novel classes of chemotaxis/migratory inhibitors for drug development and research tools for targeting chemotactic pathways universal to humans and other systems.
Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists.
Hu X, Myhr C, Huang Z, Xiao J, Barnaeva E, Ho BA, Agoulnik IU, Ferrer-Alegre M, Marugan J, Southall N, Agoulnik AI
Biochemistry , (55), 1772-83, 2016.
Article Pubmed
The GPCR relaxin family peptide receptor 1 (RXFP1) mediates the action of relaxin peptide hormone, including its tissue remodeling and antifibrotic effects. The peptide has a short half-life in plasma, limiting its therapeutic utility. However, small-molecule agonists of human RXFP1 can overcome this limitation and may provide a useful therapeutic approach, especially for chronic diseases such as heart failure and fibrosis. The first small-molecule agonists of RXFP1 were recently identified from a high-throughput screening, using a homogeneous cell-based cAMP assay. Optimization of the hit compounds resulted in a series of highly potent and RXFP1 selective agonists with low cytotoxicity, and excellent in vitro ADME and pharmacokinetic properties. Here, we undertook extensive site-directed mutagenesis studies in combination with computational modeling analysis to probe the molecular basis of the small-molecule binding to RXFP1. The results showed that the agonists bind to an allosteric site of RXFP1 in a manner that closely interacts with the seventh transmembrane domain (TM7) and the third extracellular loop (ECL3). Several residues were determined to play an important role in the agonist binding and receptor activation, including a hydrophobic region at TM7 consisting of W664, F668, and L670. The G659/T660 motif within ECL3 is crucial to the observed species selectivity of the agonists for RXFP1. The receptor binding and activation effects by the small molecule ML290 were compared with the cognate ligand, relaxin, providing valuable insights on the structural basis and molecular mechanism of receptor activation and selectivity for RXFP1.
A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation.
Bernstock JD, Lee YJ, Peruzzotti-Jametti L, Southall N, Johnson KR, Maric D, Volpe G, Kouznetsova J, Zheng W, Pluchino S, Hallenbeck JM
J. Cereb. Blood Flow Metab. , (36), 426-41, 2016.
Article Pubmed
The conjugation/de-conjugation of Small Ubiquitin-like Modifier (SUMO) has been shown to be associated with a diverse set of physiologic/pathologic conditions. The clinical significance and ostensible therapeutic utility offered via the selective control of the global SUMOylation process has become readily apparent in ischemic pathophysiology. Herein, we describe the development of a novel quantitative high-throughput screening (qHTS) system designed to identify small molecules capable of increasing SUMOylation via the regulation/inhibition of members of the microRNA (miRNA)-182 family. This assay employs a SHSY5Y human neuroblastoma cell line stably transfected with a dual firefly-Renilla luciferase reporter system for identification of specific inhibitors of either miR-182 or miR-183. In this study, we have identified small molecules capable of inducing increased global conjugation of SUMO in both SHSY5Y cells and rat E18-derived primary cortical neurons. The protective effects of a number of the identified compounds were confirmed via an in vitro ischemic model (oxygen/glucose deprivation). Of note, this assay can be easily repurposed to allow high-throughput analyses of the potential drugability of other relevant miRNA(s) in ischemic pathobiology.
Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.
He S, Xiao J, Dulcey AE, Lin B, Rolt A, Hu Z, Hu X, Wang A, Xu X, Southall N, Ferrer-Alegre M, Zheng W, Liang TJ, Marugan J
J. Med. Chem. , (59), 841-53, 2016.
Article Pubmed
Recently, we reported that chlorcyclizine (CCZ, Rac-2), an over-the-counter antihistamine piperazine drug, possesses in vitro and in vivo activity against hepatitis C virus. Here, we describe structure-activity relationship (SAR) efforts that resulted in the optimization of novel chlorcyclizine derivatives as anti-HCV agents. Several compounds exhibited EC50 values below 10 nM against HCV infection, cytotoxicity selectivity indices above 2000, and showed improved in vivo pharmacokinetic properties. The optimized molecules can serve as lead preclinical candidates for the treatment of hepatitis C virus infection and as probes to study hepatitis C virus pathogenesis and host-virus interaction.
Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay.
Hu Z, Hu X, He S, Yim HJ, Xiao J, Swaroop M, Tanega C, Zhang Y, Yi G, Kao CC, Marugan J, Ferrer-Alegre M, Zheng W, Southall N, Liang TJ
Antiviral Res. , (124), 20-9, 2015.
Article Pubmed
Hepatitis C virus (HCV) poses a major health threat to the world. The recent development of direct-acting antivirals (DAAs) against HCV has markedly improved the response rate of HCV and reduced the side effects in comparison to the interferon-based therapy. Despite this therapeutic advance, there is still a need to develop new inhibitors that target different stages of the HCV life cycle because of various limitations of the current regimens. In this study, we performed a quantitative high throughput screening of the Molecular Libraries Small Molecule Repository (MLSMR) of ∼350,000 chemicals for novel HCV inhibitors using our previously developed cell-based HCV infection assay. Following confirmation and structural clustering analysis, we narrowed down to 158 compounds from the initial ∼3000 molecules that showed inhibitory activity for further structural and functional analyses. We were able to assign the majority of these compounds to specific stage(s) in the HCV life cycle. Three of them are direct inhibitors of NS3/4A protease. Most of the compounds appear to act on novel targets in HCV life cycle. Four compounds with novel structure and excellent drug-like properties, three targeting HCV entry and one targeting HCV assembly/secretion, were advanced for further development as lead hits. These compounds represent diverse chemotypes that are potential lead compounds for further optimization and may offer promising candidates for the development of novel therapeutics against HCV infection. In addition, they represent novel molecular probes to explore the complex interactions between HCV and the cells.
High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.
He S, Jain P, Lin B, Ferrer-Alegre M, Hu Z, Southall N, Hu X, Zheng W, Neuenswander B, Cho CH, Chen Y, Worlikar SA, Aubé J, Larock RC, Schoenen FJ, Marugan J, Liang TJ, Frankowski KJ
ACS Comb Sci , (17), 641-52, 2015.
Article Pubmed
Using a high-throughput, cell-based HCV luciferase reporter assay to screen a diverse small-molecule compound collection (∼ 300,000 compounds), we identified a benzofuran compound class of HCV inhibitors. The optimization of the benzofuran scaffold led to the identification of several exemplars with potent inhibition (EC50 < 100 nM) of HCV, low cytotoxicity (CC50 > 25 μM), and excellent selectivity (selective index = CC50/EC50, > 371-fold). The structure-activity studies culminated in the design and synthesis of a 45-compound library to comprehensively explore the anti-HCV activity. The identification, design, synthesis, and biological characterization for this benzofuran series is discussed.
Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays.
Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, Cox K, Austin C, Simeonov A, Sittampalam S, Husain S, Franklin N, Wild DJ, Yang JJ, Sutherland JJ, Thomas C
PLoS ONE , (10), e0130796, 2015.
Article Pubmed
Phenotypic assays have a proven track record for generating leads that become first-in-class therapies. Whole cell assays that inform on a phenotype or mechanism also possess great potential in drug repositioning studies by illuminating new activities for the existing pharmacopeia. The National Center for Advancing Translational Sciences (NCATS) pharmaceutical collection (NPC) is the largest reported collection of approved small molecule therapeutics that is available for screening in a high-throughput setting. Via a wide-ranging collaborative effort, this library was analyzed in the Open Innovation Drug Discovery (OIDD) phenotypic assay modules publicly offered by Lilly. The results of these tests are publically available online at www.ncats.nih.gov/expertise/preclinical/pd2 and via the PubChem Database (https://pubchem.ncbi.nlm.nih.gov/) (AID 1117321). Phenotypic outcomes for numerous drugs were confirmed, including sulfonylureas as insulin secretagogues and the anti-angiogenesis actions of multikinase inhibitors sorafenib, axitinib and pazopanib. Several novel outcomes were also noted including the Wnt potentiating activities of rotenone and the antifolate class of drugs, and the anti-angiogenic activity of cetaben.
High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells.
Kumari D, Swaroop M, Southall N, Huang W, Zheng W, Usdin K
Stem Cells Transl Med , (4), 800-8, 2015.
Article Pubmed
UNLABELLED: : Fragile X syndrome (FXS), the most common form of inherited cognitive disability, is caused by a deficiency of the fragile X mental retardation protein (FMRP). In most patients, the absence of FMRP is due to an aberrant transcriptional silencing of the fragile X mental retardation 1 (FMR1) gene. FXS has no cure, and the available treatments only provide symptomatic relief. Given that FMR1 gene silencing in FXS patient cells can be partially reversed by treatment with compounds that target repressive epigenetic marks, restoring FMRP expression could be one approach for the treatment of FXS. We describe a homogeneous and highly sensitive time-resolved fluorescence resonance energy transfer assay for FMRP detection in a 1,536-well plate format. Using neural stem cells differentiated from an FXS patient-derived induced pluripotent stem cell (iPSC) line that does not express any FMRP, we screened a collection of approximately 5,000 known tool compounds and approved drugs using this FMRP assay and identified 6 compounds that modestly increase FMR1 gene expression in FXS patient cells. Although none of these compounds resulted in clinically relevant levels of FMR1 mRNA, our data provide proof of principle that this assay combined with FXS patient-derived neural stem cells can be used in a high-throughput format to identify better lead compounds for FXS drug development. SIGNIFICANCE: In this study, a specific and sensitive fluorescence resonance energy transfer-based assay for fragile X mental retardation protein detection was developed and optimized for high-throughput screening (HTS) of compound libraries using fragile X syndrome (FXS) patient-derived neural stem cells. The data suggest that this HTS format will be useful for the identification of better lead compounds for developing new therapeutics for FXS. This assay can also be adapted for FMRP detection in clinical and research settings.
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.
He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang A, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer-Alegre M, Zheng W, Chayama K, Marugan J, Liang TJ
Sci Transl Med , (7), 282ra49, 2015.
Article Pubmed
Hepatitis C virus (HCV) infection affects an estimated 185 million people worldwide, with chronic infection often leading to liver cirrhosis and hepatocellular carcinoma. Although HCV is curable, there is an unmet need for the development of effective and affordable treatment options. Through a cell-based high-throughput screen, we identified chlorcyclizine HCl (CCZ), an over-the-counter drug for allergy symptoms, as a potent inhibitor of HCV infection. CCZ inhibited HCV infection in human hepatoma cells and primary human hepatocytes. The mode of action of CCZ is mediated by inhibiting an early stage of HCV infection, probably targeting viral entry into host cells. The in vitro antiviral effect of CCZ was synergistic with other anti-HCV drugs, including ribavirin, interferon-α, telaprevir, boceprevir, sofosbuvir, daclatasvir, and cyclosporin A, without significant cytotoxicity, suggesting its potential in combination therapy of hepatitis C. In the mouse pharmacokinetic model, CCZ showed preferential liver distribution. In chimeric mice engrafted with primary human hepatocytes, CCZ significantly inhibited infection of HCV genotypes 1b and 2a, without evidence of emergence of drug resistance, during 4 and 6 weeks of treatment, respectively. With its established clinical safety profile as an allergy medication, affordability, and a simple chemical structure for optimization, CCZ represents a promising candidate for drug repurposing and further development as an effective and accessible agent for treatment of HCV infection.


text:
Cart is empty
Track my order(s)
Free Shipping on orders over $150! *Exclusions Apply
Get the most out of your UTV or ATV with performance upgrades from Pure Diesel Power.
Pure Diesel Power 2600 S Galvin Avenue Marshfield, WI 54449 PureDieselPower.com Phone: 715-254-1833 Fax: 715-898-1274
My account
PDP Information
Customer Service
© 2006-2019 Pure Diesel Power LLC. Powered by Pure Diesel Power!


text:
Fearless Stars
A thrilling journey filled with magic and second chances set in a modernized fantasy world where a Holy-touched girl and a would-be king must fight for survival after a brutal attack on their capital perfect for fans of the Final Fantasy franchise.
Ally, her two friends, Brenna and Lizbeth, and her little sister escape a brutal attack on their capital only to find themselves on the run. Ally's seemingly ordinary life takes another abrupt turn when she discovers that she is suddenly Holy-touched and in a magic-seized land at war, it is another thing she must keep secret.
Marcus, the would-be-king and military officer, barely escapes the destruction of Dowling City. With Marcus as the sudden face of the rebellion and Ally as one of the kingdom's last Sars, they must embrace their destinies or lose Sundria forever.
- 84256 words
- About 337 pages


text:
The aim of the present study was to analyse the dose rate effect of gamma radiation at the level of mutations, chromosomal aberrations, and cell growth in TK6 cells with normal as well as reduced levels of hMTH1 protein. TK6 cells were exposed to gamma radiation at dose rates ranging from 1.4 to 30.0 mGy/h (chronic exposure) as well as 24 Gy/h (acute exposure). Cell growth, frequency of thymidine kinase mutants, and of chromosomal aberrations in painted chromosomes 2, 8, and 14 were analysed. A decline in cell growth and an increase in unstable-type chromosomal aberrations with increasing dose rate were observed in both cell lines. A dose rate effect was not seen on mutations or stable-type chromosomal aberrations in any of the two cell lines. Reduction in the hMTH1 protein does not influence the sensitivity of TK6 cells to gamma radiation. This result fits well with data of others generated with the same cell line.
Ultraviolet radiation (UVR) is known to be highly mutagenic. What types of DNA lesions that are induced by different UVR wavelengths are still a matter of debate. UVR induces mutagenesis mostly by the formation of photoproducts and the induction of reactive oxygen species (ROS). ROS can give rise to mutations via oxidation of nucleotides in the DNA or the nucleotide pool. Oxidized nucleotides in the nucleotide pool can thereby be incorporated into the DNA during replication and ultimately give rise to mutations. MTH1 however, dephosphorylates oxidized nucleotides in the nucleotide pool, in particular 8-oxo-dGTP and 2-OH-dATP, and inhibits their incorporation into the DNA.The aim of the present study was to investigate the role of MTH1 in mutagenesis and cytogenetic damage induced by UVR in a human lymphoblastoid TK6 cell line. The clonogenic survival, mutant frequency and micronucleus frequency were measured following exposure to UVA, UVB and UVC in MTH1-knockdown and wild-type TK6 cells. As a biomarker for oxidative damage the level of intracellular and extracellular 8-oxo-dG was measured in TK6 cells exposed to UVA. The mutational spectra of UVA-induced mutations at the thymidine kinase gene in MTH1-knockdown and wild-type TK6 cells were investigated.The results show that MTH1 protects against UVA and UVB mutagenesis significantly. MTH1, however, has been shown to offer no protection against UVR-induced cytogenetic damage and is therefore suggested to mainly inhibit mutagenesis. The mutational spectra show that GC>AT and AT>GC transitions are the dominant mutation types in cells exposed to UVA.In conclusion, MTH1 protects TK6 cells against mutagenesis induced by longer wavelengths of UVR. This indicates that the nucleotide pool is a significant target in mutagenesis for longer wavelengths of UVR. The type of mutations induced by UVA, GC>AT and AT>GC, can be formed by the incorporation of 2-OH-dATP from nucleotide pool into the DNA. UVA is therefore suggested to induce mutations by induction of oxidized nucleotides such as 2-OH-dATP.
At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Manuscript.
Humans are constantly exposed to different types of radiations. It has been suggested that low dose and low dose rate of γ-radiation as well as ultra violet A (UVA) induce oxidative stress in cells that may promote mutations. The mechanisms behind radiation-induced oxidative stress and its relation to genotoxicity and cancer induction are not well understood. In the majority of investigations, the DNA molecule has been studied as the target for mutations, however the results obtained in our group point out that DNA bases in the cytoplasm could also be a significant target. MTH1 and MYH are two of the key proteins of the repair pathway that prevent mutations arising from oxidized DNA bases. In this thesis, we studied the role of MTH1 and MYH in genotoxicity of UVA and γ-radiation. The adaptive response to low dose rates of γ-radiation was also investigated. MTH1 and/or MYH were knockdown in human lymphoblastoid TK6 cells. The clonogenic survival, mutant frequency and chromosomal aberration assays were performed following UVA or γ-radiation exposure. Our results indicated that acute exposure to UVA or γ-radiation affects cell survival and also increases the mutant frequency above the background. The mutant frequency in MTH1 deficient cells was higher than that in wild types after UVA exposure. Following γ-radiation exposure, a higher mutant frequency was observed in the MYH and MTH1 deficient cells, in comparison to either MYH or MTH1 deficient or wild type cells. No dose rate effect of γ-radiation for mutations was observed. An adaptive response to γ-radiation was observed at the mutation level in MCF-10A cells but not at the survival level. In summary, our results suggest that; a) MYH and MTH1 cooperatively protect cells against genotoxic effects of γ-radiation; b) MTH1 protects cells from UVA-induced mutations; c) low dose rates of γ-radiation may induce an adaptive response at the mutation level; d) there is no dose rate effect for γ-radiation at the mutation level.
At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Manuscript. Paper 3: Manuscript.


text:
- Administrative Tribunal Documents
- Board Documents
- Budget Documents
- Compliance Reviews
- Corporate Procurement
- Departmental Annual Reports
- Environmental & Social Assessments
- Evaluation Reports
- Financial Information
- Integrity & Anti-Corruption Reports
- Legal Documents
- Policy Documents
- Project-related Procurement
- Projects & Operations
- Publications
- Strategy Documents
You are here
NEPAD - IPPF User Guide
The New Partnership for Africa's Development (NEPAD) has identified infrastructure as one of the major parameters for economic growth and poverty reduction in Africa. The present state of infrastructure as well as the infrastructure gap between Africa and more developed countries constitutes a serious handicap to African production and improved productivity and competitiveness. Without addressing its infrastructure needs, Africa will continue to remain uncompetitive in the global market. In June 2002, at the G8 Summit in Kananaskis, the Prime Minister of Canada announced Canadian commitments in support of the Africa Action Plan, the G8 response to (NEPAD), including initiatives related to infrastructure development.


text:
The Hartford Foundation has created 29 new funds, one for each of the towns in our region.---!>
For 90 years, we have advanced equity and opportunity in our 29-town region. The map below illustrates the reach of our grants over the past five years, supporting over 650 nonprofits and those they serve.
A look at the everyday actions that shape our community and create a more vibrant Greater Hartford.
Our donors bring a wide range of interests, convictions and ambitions to the table. We listen to and work closely with them to determine the type of fund that best suits their circumstances and philanthropic goals.
"I give to improve life now and in the future for people in my community."
-Nelly Rojas Schwan, member of the Latino Endowment Fund, and part of our I Am A Philanthropist campaign
Every meaningful process starts with listening. We are committed to encouraging new ideas and new ways of collaborating as we respond to the highest, most pressing needs in the communities we serve.
A diverse community calls for diversified investments. From building the capacity of nonprofits, to supporting the next generation of leaders, we are proud to put resources behind meaningful efforts.
Our carefully managed endowment guarantees the endurance of our resources and the progress it supports. Its strength allows us to protect tomorrow's assets while steadfastly addressing today's needs.
New Metro Hartford Future Report Highlights Key Opportunities to Advance the Region's Economy
The Hartford Youth Service Corps (HYSC) was created by Mayor Luke Bronin in 2016 to reengage at-risk or disconnected youth in paid service learning and academic and workforce development support to help them get back in school or on the path to a job.
An estimated 3,000 children enter Connecticut's juvenile justice system each year. Once released from custody, about 75 percent of those youthful offenders are rearrested, with the majority being recommitted.
7-part series examines several key issues facing Greater Hartford
Parent-led nonprofit with community support collaborates with anonymous donor to raise more than $400,000 to create playground
The Hartford Foundation is pleased to fund a variety of resources, that can help you stay informed about important community news, access local services you need, and find meaningful volunteer opportunities.
Each year, the Hartford Foundation partners with generous individuals, families, and organizations to improve the quality of life across the region.


text:
Playing cost-free video games is certainly amazing as teenagers frequently locate themselves in teams checking out cybercafes and also delighting in brand-new on the internet video games they uncover with each other. Factoring in the reality that, the ordinary cybercafe fees in between $0.50 cents to $1.00 an hr, this is definitely more affordable than clubbing.
Video gaming, specifically playing cost-free video games online has actually made incredible development as well as is below to remain for a very long time ahead.
Making use of this social atmosphere, some internet sites supply complimentary conversation so video game gamers can socialize as well as conversation, making brand-new good friends as well as conference individuals from around the globe. Once more Gamerevolt is one such system. Their chat room permits site visitors to develop their very own exclusive areas where they can welcome their close friends or brand-new individuals they have actually satisfied for a laid-back conversation. Others include even more social enhancing web content such as online forums, downloads and also video games rip off to their site visitors. This consists of X box video game rips off Ps 2 video game rips off Video game child rips off and also rips off forother systems.
To conclude, the players' heaven is readied to end up being also much better, with even more complimentary video games being produced day-to-day, and also systems ending up being much more innovative and also using a much better social environment.
Overall, on the internet pc gaming is an eruptive and also social atmosphere as well as readied to broaden further in the future.
As an outcome of this surge of appeal, there are lots of systems supplying several types of totally free online video games without any demand for downloading and install. Consequently, pc gaming fans have lots of opportunities readily available to them. Some concentrate on a certain category such as experience, activity, method, board, or card video games while others branch out and also provide a wide variety of cost-free video games including all the groups over.
Quickly changing most various other kinds of home entertainment such as Television as well as also standard video gaming consoles, it is habit-forming, inexpensive as well as most notably FREE.
Free on the internet experience video games are the simplest to find by. Function Playing Gamings enables the player to pose a preferred personality while site visitors can likewise select an on-line companion to play multiplayer video games improving the extremely social nature of video gaming. Some systems provide a system of ranking which additionally boosts the experience of brand-new site visitors that check out later on. Furthermore, details remarks can be left on video games on some internet sites. Favorite video games can be bookmarked or sent out to close friends or put on social media accounts such as Myspace.
A current comScore study validated the influence of net video games is really felt in broader areas of culture. They found a big percent of older players – simply under 53% – of them were ladies. So what's the draw of these video games? Most importantly, they are enjoyable and also it is an opportunity for the hectic Mama to fail to remember duties and obtain shed worldwide of on the internet pc gaming. Without a doubt, they are
not curious about anything complex, simply an excellent brainteaser or approach video game.
Additionally, there are some video gaming internet sites that are tailored to providing a variety of video games in practically every style. One such system is Gamerevolt which uses cost-free video games in classifications such as method, experience, RPG, approach, challenges simply among others. It is much more like a one quit purchase video games just they are complimentary. The benefits of totally free online video games is that you can do it whenever you can save a couple of mins or throughout your coffee break for circumstances. Several of these video games are instructional or brainteasers, others are for pure enjoyment. Free on-line method video games, such as Sudoku, for example, examination your mind intelligence without requiring a pen neither paper.


text:
Never Before Offered for Public Sale!
For Sale ONLY at AUCTION by the Direction of Martin County!
One of the LAST residential lots in River Forest (no age restrictions) situated on a cul-de-sac.
River Forest community amenities include (if you opt in): clubhouse, pool, and fitness center.
Bring your boat! Community boat ramp with easy access to the St. Lucie River.
GREAT location close to "A" rated schools and just minutes to I-95!
PERFECT for commuters going north or south!
The auction is being conducted onsite at SW Century Way. Registration begins onsite at 4PM with bidding to start at 5PM.
Never Before Offered at Public Sale!
Former fire station that has been rezoned commercial For Sale ONLY at AUCTION by the Direction of Martin County!
PERFECT for ANY Contractor!!
Auction being conducted onsite with registration starting at 11am and bidding starts at noon.
Never Before Offered for Public Sale!
Two (2) mobile home lots in the Northwood neighborhood For Sale ONLY at AUCTION!
The auction is being conducted onsite at the corner of NE 17th Street and Green River Parkway with registration starting at 4pm and bidding to start at 5pm.


text:
Voted Lake Tahoe's Best Place to Spend The Night, MontBleu Resort Casino & Spa, is the perfect destination to hold your next meeting or special event.
Our $25+ Million in property renovations are on track and our 438 guests rooms are now complete along with our 14,000 sq. ft. convention and banquet space.
Planning a meeting or special event in the upcoming months? The MontBleu is offering discounts starting September 7, 2015 to December 17, 2015, Sunday through Thursday as follows:
* 15% Guest Room Rate Discount
* 1 Comp Room per 30 Actualized
* 15% Banquet Lunch or Dinner Discount
* 15% A/V & WiFi Discount
The Holidays are right around the corner and the MontBleu Resort is a perfect venue for Christmas Parties. Please call today for availability and pricing.


text:
I think I have a favourite child - What should I do? - The Unfit Parent
Ever had a favourite child? If you have you've probably never said it out loud. Having a favourite child is not something we strive for as parents but often happens whether we know it or not. I had a favourite child, recognized it early and here's what I did about it.
Post to Tumblr


text:
CDD Manager, Commercial bank - Account Opening
|Hong Kong, Hong Kong
|Contract Type:
|Banking & Financial Services
|HK$25000.00 - HK$35000 per month
Our client is a well establish middle-size commercial bank in Hong Kong. Due to expansion, they are currently hiring CDD Associate/ Officer/ Assistant Manager to join their team.
Directly reporting to Head of Operation and lead a team of 5, this role will be responsible for day to day compliance task including KYC, CDD and general client onboarding issues. You will be also responsible for account opening, periodic review and remediation project approval for clients.
- 5 years' experience in KYC/ CDD/ Client onboarding in commerical or retail banking
- Strongly understanding in operation and compliance requirement
- Proficient in English and Chinese
Interested parties, please click "APPLY NOW" or send your application to email@example.com or contact at Anthony Chan +852 3103 4363
Data provided is for recruitment purposes only


text:
Another example of somatic tinnitus is that caused by temperomandibular joint disorder. The temporomandibular joint (TMJ) is where the lower jaw connects to the skull, and is located in front of the ears. Damage to the muscles, ligaments, or cartilage in the TMJ can lead to tinnitus symptoms. The TMJ is adjacent to the auditory system and shares some ligaments and nerve connections with structures in the middle ear.
High-pitched ringing. Exposure to a very loud noise or a blow to the ear can cause a high-pitched ringing or buzzing that usually goes away after a few hours. However, if there's hearing loss as well, tinnitus may be permanent. Long-term noise exposure, age-related hearing loss or medications can cause a continuous, high-pitched ringing in both ears. Acoustic neuroma can cause continuous, high-pitched ringing in one ear.
Oticon Tinnitus SoundSupport works by adding sound to the buzzing, hissing, or roaring you already hear. This may seem peculiar, but in fact, the relief sounds (which are dynamic and soothing) can mix with and distract you from those bothersome noises, giving you control over your condition. The flexible program includes a variety of relief sounds that can ease the effects of tinnitus. Your audiologist can personalize the sounds to your needs and preferences, and they can be used alongside Tinnitus Retraining Therapy for instruction and support.
With respect to incidence (the table above is about prevalence), Martinez et al (2015) reported that there were 5.4 new cases of tinnitus per 10,000 person-years in England. We don't find this statistic much use as tinnitus is highly prevalent in otherwise normal persons. It seems to us that their study is more about how many persons with tinnitus were detected by the health care system -- and that it is more a study of England's health care system than of tinnitus.
If the cause of your tinnitus is excessive earwax, your doctor will clean out your ears by suction with a small curved instrument called a curette, or gently flush it out with warm water. If you have an ear infection, you may be given prescription ear drops containing hydrocortisone to help relieve the itching and an antibiotic to fight the infection.
Hyperacusis is a different, but related condition to tinnitus. People with hyperacusis have a high sensitivity to common, everyday environmental noise. In particular, sharp and high-pitched sounds are very difficult for people with hyperacusis to tolerate—sounds like the screeching of brakes, a baby crying or a dog barking, a sink full of dishes and silverware clanging. Many people with tinnitus also experience hyperacusis—but the two conditions don't always go together.
Tinnitus remains a symptom that affects the lives of millions of people. Research is directed not only at its treatment, but also at understanding why it occurs. Research by doctors at the University at Buffalo, The State University of New York, Dalhousie University (Canada), and Southeast China University have published research using electrophysiology and functional MRI to better understand what parts of the brain are involved in hearing and the production of tinnitus. Their research has found that much larger areas of the brain are involved with the process of hearing than previously believed, which may help direct future diagnostic and therapeutic options.
Ringing-in-the-ears or a fullness-of-the-head sensation are the most common symptoms of tinnitus. While ringing is the most common experience, the noise can also sound like a buzzing, hissing or whizzing sound. It can range from a low pitch to a high pitch and may be soft or loud at times. For some, tinnitus seems to get louder at night, just before sleep when no other sounds are competing with it. Tinnitus can remain constant or come and go intermittently. In severe cases, the ringing in the ears is loud enough to interfere with work or daily activity, whereas those with mild tinnitus can experience soft ringing that is no more than a minor annoyance.


text:
Hi all,
My name is Derek and yes last name Beans , new here just got my Evoque last Saturday and really enjoy it . Got a 2015 Pure Plus in Kaikora Stone and black trimmings and wheels and light interior it was on the showroom floor with 12 miles on the clock . I got the front windows tinted and that's it for now , Im a car person mostly Mustangs and actually got rid of one of my Stangs for this as I have been looking at these since 2012 and wasn't sure about it . After doing plenty of research and seeing they had the Ecoboost motor from Ford it was a win . So far I am impressed with the Evoque and only wish it had a tad more power and less throttle lag from the drive by wire. I am sure there are solutions for this as I am reading some on here. If there is anybody in the Florida area that you guys know gets into these and produces parts/ products or tunes please let me know .
I like to MOD my cars and see where they get to here is a article on one of my Mustangs I currently have still . Since this was done the car has went under the knife again .
2003 Ford Mustang GT - Cool Beans
Hope to meet and make some new friends here , looking forward to learning about these Evoque's a little more and see where this one gets to .


text:
In pictures: Saoirse Ronan puts palatial Irish home up for sale
Saoirse Ronan has put her home in Ireland up for sale for €1.5 million just two years after moving in.
The Oscar-nominated actress is selling the palatial Pine Lodge in Greystones, Co Wicklow just a short drive outside Dublin, after deciding to spend more time in London and New York for work.
The 25-year-old bought the five-bedroom house in 2017 for €1.4m and has spent a substantial amount renovating the five-bedroom home.
She also owns a three-bedroom terraced house in London's Notting Hill.
Built in the 1970s and covering an area of 450sqm, the sprawling property has been revamped and decorated in a New-York inspired style with newly-fitted kitchen and bathrooms.
The private setting of the house is fit for any A-lister and agents Galvin Property said the private wrought iron electronic gates along a sweeping tree lined driveway offer a sense of seclusion that's hard to find.
It's been redesigned and modernised in the past two years to produce a home of unparalleled quality in the area, according to the agent.
Of particular note is the light-filled breakfast room, of which they say: "The current owner has painstakingly designed and decorated this open-plan room to be practical, comfortable and aesthetically-impressive in all equal measures."
One of the bedrooms has been converted into a large walk-in wardrobe with a luxurious en-suite bathroom and separate shower "comparable to a hotel suite in uptown New York".
All five of the bedrooms are situated on the first floor, while on the second floor there's room for a home cinema, a gym or full guest accommodation with a fully-functional kitchen.
The back garden also has fruit trees and raised beds with fresh herbs with patio herbs opening onto private greenery.
Saoirse Ronan secured a Golden Globe for best actress in 2018 for her title role in Greta Gerwig's film Lady Bird.
She recently received rave reviews for her role in Mary Queen Of Scots and is already sparking speculation that she's up for another Oscar nod for her most recent performance in the latest adaptation of Little Women.
Belfast Telegraph Digital


text:
Anesthesiology (Anesthesiology Assistant) • Male
Redmond Regional Medical Center501 Redmond Rd NW Rome, GA 30165
Make an Appointment(706) 291-0291
Douglas McNiece, PA is an anesthesiology assistant in Rome, GA. He specializes in anesthesiology (anesthesiology assistant).
Search for your insurance provider
Douglas McNiece accepts
Accepted insurance can change. Please double-check when making an appointment.


text:
High-Tech Dentistry
More comfort and better results
Dr. Kim has equipped his practice with the latest dental technology and tools to make your treatment more comfortable and efficient. His use of such high-quality instruments makes diagnosis more accurate, surgeries less invasive and routine treatment more gentle. Dr. Kim's extensive training in each piece of advanced equipment allows him to produce more aesthetically pleasing and fully functional results.
Galileos Comfort Plus 3D Cone Beam CT (CBCT) Scanner
Our revolutionary Galileos 3D Cone Beam scanner captures digital 3D X-rays of the patient's face and all important anatomical structures of the craniofacial region. This advanced technology allows Dr. Kim to get a detailed 3D view of your teeth and the supporting bone structures of your mouth, increasing the accuracy and efficiency of diagnosis and treatments in implantology, endodontics, oral surgery, orthodontics and general dentistry.
Dr. Kim uses the CEREC Omnicam to scan and capture a 3D model of your teeth. The CEREC computer software is then used to create a restoration that can be milled in the office just minutes later and bonded to your tooth. The entire process only takes a couple of hours, so that means with our in-office CEREC laboratory Dr. Kim can create restorations in only one visit!
Ergonomic Dental Chairs
Our office features high-quality dental chairs by Adec. These advanced chairs maximize comfort for the patient during treatment and have many ergonomic features including a thin and comfortable backrest, LED light, easier chair mobility and compact organization system.
Digital Intraoral X-rays
Dr. Kim uses the Progeny Preva to take digital intraoral X-rays. This advanced device is fast, convenient and applicable to nearly all standard dental diagnoses and treatments.
Digital Panoramic X-rays
Digital Panoramic X-rays use 80% less radiation than conventional X-ray machines and help dentists plan various dental treatments and surgery. With this machine, Dr. Kim can comfortably take a panoramic X-ray image of your entire jaw and display it on high resolution screens. The images are produced instantaneously and allow you to view and better understand Dr. Kim's diagnosis and treatment plan.
High-Powered Microscope
Dr. Kim uses a high-powered microscope which allows him to see a tooth up to 20x its normal size. This is useful in many applications including general and cosmetic dentistry, endodontic procedures and more.
Magnification Loupes
Dr. Kim uses high-resolution magnifying loupes to see even the smallest details of your teeth. These increase visibility and accuracy when identifying issues in your mouth and during surgical procedures.
Rotary Endodontic Handpiece
Rotary endodontic handpieces have become the preferred method of performing certain endodontic procedures such as root canals. Dr. Kim uses an electric handpiece to perform procedures faster, reducing your time in the dental chair and making it a more comfortable experience.
Electric Handpieces
Dr. Kim uses electric handpieces for reduced noise, precise control and speed. This results in increased efficiency of procedures and less time in the dental chair for you.
The Wand
Dr. Kim uses the Wand for painless computerized injections. The Wand's computer provides a constant and precise flow of anesthetic directly ahead of the needle which reduces any discomfort to an unnoticeable level.
Piezo Scalers
Piezo scalers remove plaque, tartar and bacteria from the tooth surface and gums by emitting high-frequency vibrations. Our ultrasonic scalers have a convenient intensity adjustment for patients with sensitive teeth.
The DIAGNOdent is a handheld device that Dr. Kim uses to scan your teeth for cavities. The DIAGNOdent uses lasers that can detect even the smallest cavities and provide useful information that allows Dr. Kim to prevent future tooth decay.
To make an appointment, call (714) 832-8000 or click here to request an appointment online.


text:
24,000,000 people each year use this site to learn the management, leadership and personal excellence skills they need for a happy, successful career. Join them!
Adidas Run Lux Clima W Off White Grey Ash Pearl Running Training shoes CQ0595Adidas BD7825 Falcon Running shoes pink purple SneakersAdidas shoes Women Sneakers Black 97946 BDT OUTLETAdidas Originals I-5923 Women's Aero bluee White Crystal White DA8800
Sign up for a month's trial of the Mind Tools Club and get these four workbooks for FREE!Find Out More
L&D Success Story: Implementing a Culture of Lifelong Learning at AstraZeneca
June 11, 4 p.m. BST / 8 a.m. PT / 11 a.m. ET.Book Your Place
Discover the Seven Secrets of Organizational Success!Adidas ADV 91-18 womens gym shoes-8.5 B37530 torsion mint green black new
Take our 5-minute test to find out which skills YOU need to develop.CLICK to Get Started
Learning faster is better for business!Read More
Take our quick self-test, and find the tools you need to communicate powerfully.CLICK to Get Started
Take our quick self-test and discover key tools that will help you achieve more every day.CLICK to Get Started
New with box: A brand-new, unused, and unworn item (including handmade items) in the original packaging (such as ... Read moreabout the condition
|Tennis & Racquet Sports
|Size Type:
|US Shoe Size (Women's):
|Multiple Variations
What role do stories play in the workplace? Join this interesting #MTtalk discussion on Friday at 1pm EST / 5pm GMT… Adidas blue Deerupt Runner At bluetin Ecrtin Actpur
Why can #storytelling be so compelling? We'd love to hear your thoughts during Adidas by Stella Mccartney Barricade Clay W Women's Tennis shoes White S75663 this Friday. NYC 1pm / Londo… twitter.com/i/web/status/1…
What is the role of stories in society? We're going to chat about storytelling during #MTtalk on Friday. Please joi… twitter.com/i/web/status/1…
What do you think makes a #successful Adidas Originals NMD CS1 Primeknit B37658 sz 9.5 in purplec?
@adrianbignell58 Thanks Adrian for sharing our article on #optimism. We call all benefit from reminding ourselves o… twitter.com/i/web/status/1…


text:
Investor Shares
MXC Capital ups stake in Tax Systems, cuts stake in Castleton Technology
Mon 06 Aug 2018 09:06
MXC Capital said it had lifted its holding in corporate tax software provider Tax Systems to around 25.5% after selling shares in Castleton Technology.
Around 4.8m Castleton Technology shares were sold at 101.5p each, the company said.
The proceeds were used to purchase around 4.9m shares in Tax Systems at a price of 89.5p each.
MXC also sold a further 2.0 Castleton shares, dropping its holding in the company to 6.65%.
The proceeds of the second sale will be used in line with MXC's stated strategy of investing in technology companies,' MXC said.
At 9:06am: (LON:MXCP) MXC Capital Plc share price was 0p at 1.25p
Story provided by Stock Market Wire


text:
Dog Box – K9 Raw Food Diet
Treat your pup to the high-quality meat she was born to love:
- 5 lbs of Ground Beef
- 2 lbs of Liver
- 2 bags of Knuckle Bones approx. 6 lbs
Your best friend deserves the best! The Dog Box features Foxhollow Farm's 100% Grassfed Beef raised without steroids, antibiotics or growth hormones.


text:
Carisa Olivea Resort & Olivea Homes are lavish residential townhouses by Patroclos Group of Companies in an elegantly crafted community in Oroklini, which merges an active living with a unique lifestyle.
With tastefully designed 3 and 4 bedroom units, it provides its residents with an attractive looking space that is created with function. Having close proximity to a number of prevalent destinations, Carisa Olivea Homes is a beautiful complex that is created to be extraordinary.
The project is situated at the outskirts of the village of Oroklini and is a stone's throw away from Yanathes, one of the main Larnaca beaches, awarded with the Blue Flag.


text:
Ladipoe – Devil You Need (Freestyle)
Download Ladipoe Devil You Need (Freestyle) Mp3
Prolific Nigerian rapper and Mavin records Singer, Ladipoe returns to the music scene with yet a brand new impressive freestyle dubbed "Devil You Need".
The rapper showcase more of his rap capabilities as he drops some good punchline on the Yazidxo and HonterOnTheBea produced beat.
Simply stream, download, then share your thoughts and opinion in the comments section below.
Leave a Reply
- South Africa7 months ago
Shimza – Ultra Resistence CPT 2019 (Mix)
- Video7 months ago
InQfive – Voltage (Original Mix)
- Video6 months ago
VIDEO: Willy Paul ft. Nandy – Hallelujah
- South Africa9 months ago
Que Deep Matured Soundz – Baby Are you Coming Ft. Edgar Thee Mc & Lindiwe
- South Africa7 months ago
Zero12Finest – Baby Are You Coming? ft. Thamagnificent2
- East Africa6 months ago
Willy Paul ft. Nandy – Hallelujah
- Video7 months ago
VIDEO: Cassper Nyovest – Move For Me Ft. Boskasie
- Music9 months ago
Rescort ft. Zlatan – Credit Alert


text:
How to Watch YouTube Videos Offline on Android
Every day an increasing number of YouTube users upload videos on this most popular global video-sharing website. Similarly, there are many Android phone or tablet users prefer to watch YouTube offline because of convenience. For example, Jason once asked for help:
"Any offline YouTube app or downloader? Google doesn't allow to directly download videos from YouTube to Android devices. But I need watch YouTube videos offline on my Samsung for music!"
If you have the same question, you will be relieved after reading this guide, including some Android YouTube downloader and desktop YouTube downloader.
Part 1: Android YouTube Downloader Apps
Option 1: TubeMate
TubeMate is one YouTube offline app for Android users. This app allows to download several YouTube videos to Android devices at the same time while browsing. After downloading, you can watch YouTube offline right with this YouTube offline android apk.
1. Install and open this application on your Android phones or tablets.
2. Search the videos you want and click the green arrow at the top of the interface.
3. Choose one version you need to download.
Option 2: TubeX
TubeX is an alternative to help watch YouTube videos offline on Android. This app also allows multiple downloads. It supports to save your favorite videos your YouTube account.
1. Run this app on your Android devices and search the video you need in the search field.
2. Choose "Download" to continue after clicking the selected video.
3. Tap one preferred version to download.
Part 2: Desktop YouTube Downloader for Android
Option 1: iSkysoft iTube Studio
iSky iTube Studio is one great desktop YouTube video downloader for Android. This downloader allows to download videos from 1000 more sites, including YouTube. It supports to convert video to any video and audio format and preset for portable devices like Android, iPhone or other phones.
1. Run this YouTube downloader on your Mac.
2. Go to YouTube.com and search your the video you want. Click the "Download" button on the screen when you open the video you find.
3. After downloading, tap "Downloaded" and push "Convert". Select Android Phone as the output format and click "OK" to start the conversion.
Option 2: MacX YouTube Downloader
MacX YouTube Downloader is a helpful Android YouTube downloader. Besides that, it enables to download videos from Facebook, Vimeo, Dailymotion, Vevo, and another 300 video-sharing sites.
1. Download this YouTube downloader and run it on your Mac.
2. Copy and paste the URL of the video you want from YouTube to the address bar and click "analyze" to load the video details.
3. Choose format of the video, click "Browse" to select an output folder on your Mac and hit "Download Now" to start YouTube videos offline download for Android.
Note: If you choose the desktop YouTube downloader for Android, you need to transfer converted videos from the output folder to your Android phones or tablets via USB cable. Then you can watch YouTube videos offline on your Android devices.


text:
PNP slams CamSur ambush of cops from medical mission
MANILA The Philippine National Police (PNP) on Monday condemned the attack against a group of policemen who were on their way back to their unit from a medical mission in Camarines Sur.
In a statement, PNP spokesperson, Chief Supt. Benigno B Durana Jr. described the attack as another example of either duplicity or lack of influence of Utrecht-based CPP/NPA/NDF (Communist Party of the Philippines-New People's Army-National Democratic Front) leaders who shamelessly ask for a meeting with PRRD (President Rodrigo Roa Duterte ) while carrying out terror attacks against security forces personnel helping less fortunate Filipinos.
He added that the CPP-NPA leadership has obviously lost control over maverick commanders of its wayward guerrilla fronts.
Durana also said the incident casts doubt anew on the sincerity of the communist rebels in talking peace with government.
Reports reaching the National Operations Center in Camp Crame said the PNP personnel who were wounded in the attack were part of the 1st Camarines Sur Provincial Mobile Force Company on their way to the Libmanan town proper from a medical mission in Barangay Bagamelon on Saturday afternoon.
Upong reaching Sitio Patag, undetermined armed men believed to be members of the New People's Army ambushed the nine-man team, wounding six members, namely PO3 Roland G Hermogeno; PO1 Vladimir Guadalupe; PO1 Roy V. Carbonell; PO1 Eliseo Jomar N. Palaroan; PO1 Daisy Bhel Genova; and PO1 Mikhail Jose P. Concina.
The wounded police officers were rushed to the Mother Seton Hospital in Naga City while PNP and Philippine Army troops launched hot pursuit operations against the suspects. (PNA)
Source: Philippine News Agency


text:
Lakeville Fire House for Workforce Housing sign now
Considering that we, the undersigned, believe the best possible use for the old Lakeville fire house, located at 9/9a Sharon Road in Lakeville Connecticut, might be for WORKFORCE HOUSING, we hereby request the following:
The Salisbury Board of Selectmen remove the property from the real estate market and require the Salisbury Affordable Housing Advisory Commission to establish an impartial subcommittee for the purpose of a comprehensive study concerning the feasibility of converting said facility into WORKFORCE apartment units.
Until such time as the results of said study are made public and properly reviewed in public forums, the property shall remain in possession of the Town of Salisbury.
A Town Meeting shall make the final decision concerning the conversion to WORKFORCE apartment units after full presentation of the study results.
Sign The Petition
Who signed this petition saw these petitions too:
Sign The Petition
If you already have an account please sign in
Help keep Online Petition free!
Please consider making a small donation today. This will allow us to keep Lakeville Fire House for Workforce Housing alive and available to a wide audience.
One-time donation
Every cent you give goes toward maintaining the website and the petitions. Even a small contributions helps!
Support the Cause
Latest Signatures
No one has signed this petition yet
Bobbi HarrisonBy:
Entertainment and MediaIn:
Petition target:
Salisbury Connecticut Board of Selectmen
No tags


text:
Exodus 16:23-30 Good News Translation (GNT)
23 and he said to them, "The Lord has commanded that tomorrow is a holy day of rest, dedicated to him. Bake today what you want to bake and boil what you want to boil. Whatever is left should be put aside and kept for tomorrow." 24 As Moses had commanded, they kept what was left until the next day; it did not spoil or get worms in it. 25 Moses said, "Eat this today, because today is the Sabbath, a day of rest dedicated to the Lord, and you will not find any food outside the camp. 26 You must gather food for six days, but on the seventh day, the day of rest, there will be none."
27 On the seventh day some of the people went out to gather food, but they did not find any. 28 Then the Lord said to Moses, "How much longer will you people refuse to obey my commands? 29 Remember that I, the Lord, have given you a day of rest, and that is why on the sixth day I will always give you enough food for two days. Everyone is to stay where he is on the seventh day and not leave his home." 30 So the people did no work on the seventh day.
Cross references:
Good News Translation (GNT)
Copyright © 1992 by American Bible Society
Deuteronomy 31:12-14 Good News Translation (GNT)
12 Call together all the men, women, and children, and the foreigners who live in your towns, so that everyone may hear it and learn to honor the Lord your God and to obey his teachings faithfully. 13 In this way your descendants who have never heard the Law of the Lord your God will hear it. And so they will learn to obey him as long as they live in the land that you are about to occupy across the Jordan."
The Lord's Last Instructions to Moses
14 Then the Lord said to Moses, "You do not have much longer to live. Call Joshua and bring him to the Tent, so that I may give him his instructions." Moses and Joshua went to the Tent,
Good News Translation (GNT)
Copyright © 1992 by American Bible Society
You'll get this book and many others when you join Bible Gateway Plus. Learn more
Starting your free trial of Bible Gateway Plus is easy. You're already logged in with your Bible Gateway account. The next step is to choose a monthly or yearly subscription, and then enter your payment information. Your credit card won't be charged until the trial period is over. You can cancel anytime during the trial period.
Click the button below to continue.
You've already claimed your free trial of Bible Gateway Plus. To subscribe at our regular subscription rate, click the button below.
It looks like you're already subscribed to Bible Gateway Plus! To manage your subscription, visit your Bible Gateway account settings.
Upgrade, and get the most out of your new account. An integrated digital Bible study library - including complete notes from the Believer's Bible Commentary and the Cultural Backgrounds Study Bible (NIV and NRSV) - is just a step away! Try it free for 30 days.
Three easy steps to start your free trial subscription to Bible Gateway Plus.


text:
1. RVA Used Cars will consign your car for a minimum of 30 days. Exceptions can always be considered and arranged contingent on special circumstances.
2. No one earns anything until your car sells. Where many dealers charge an upfront consignment fee of $300 or more, our consignment program is free! Since we need to sell your car to earn money we are motivated and focused on selling your car fast!
3. Pricing is not an issue. We don't work on a percentage of the sales price. We prefer to evaluate and agree up front on a fixed net price that will satisfy you. You don't have to be concerned about getting your price because we already agreed before your vehicle was offered for sale on our lot.
4. RVA will secure, display and prepare your vehicle for sale at our expense. Should reconditioning, repair, or special equipment be recommended or required, such services will be offered at our wholesale cost and performed only with your itemized "written" approval authorization.
5. With one of the best dealership locations in the area. RVA will aggressively market your vehicle by displaying it in a premium position on our lot. Additionally we will digitally market the vehicle on our website and other classifieds such as Craigslist, Facebook, and CarGurus.
It's easy with RVA We remove the frustration, hassle, wasted advertising expenses, and time consumed with selling the car yourself. Just think… no irritating, untimely, and bothersome phone calls from unqualified semi-serious buyers or unknown strangers visiting your residence. Also, prospective buyers many times require trade-in assistance, financing, licensing, or special warranty protection. We offer all these professional services and products "on-site" which often times proves the deciding difference in closing the sale. Services critical to every transaction, each handled by industry professionals to help ensure that your vehicle is sold quickly, effectively, and at the highest reasonable price.
Thank you. Please contact us for an honest and professional evaluation of your vehicle. We will be happy to accommodate your every request by providing knowledgeable, accurate, and timely information regarding your vehicle to ensure that you can make a confident and informed decision.