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In This Issue:
After having just returned from a wonderful African safari tour in Kenya and Tanzania, the Summer 2013 issue of the NVL Newsletter will discuss the prevalence, in African wild cats, of the common domestic cat pathogens (feline leukemia virus, feline immunodeficiency virus and Bartonella).
Evelyn Zuckerman and I (Dr. Hardy) were seated comfortably on our transatlantic flight home, after a wonderful African safari to Amboseli National Park, Lake Manyara National Park, Ngorogoro Crater, the Maasai Mara Serengeti, and the historic site of the origin of humans from Africa, the site where the Leakeys unearthed their fossil skeletons. We visited the continent where humans and domestic cats originated. More than likely, the infectious pathogens of early hominins and other animals evolved, due to climate changes, with their hosts to the present day and some became zoonotic pathogens.1,2
On the flight I was reading David Quammen's new book "Spillover," about the origins in animals of most of our new zoonotic diseases while I was racking my brain for a topic for our summer NVL newsletter. It took only about 15 minutes before the proverbial light went on to connect our early research, on African big cats, with our safari and the origin of zoonoses such as Bartonella that veterinarians often encounter. I realized that our FeLV research collaboration with Don Francis, a physician at Harvard with Max Essex in the 1970s, linked our cat work with Don who was later sent to investigate the first Ebola zoonotic outbreak in Africa. After having just photographed leopards, cheetahs and lions up close, I recalled the collaborations and publications with Steve O'Brien, Moritz Van Vuuren and Steve Osofsky on testing Africa's big cats for the common domestic cat pathogens.
Steve O'Brien has done pioneering research on the genetics and origin of domestic cats and FeLV which led him to groundbreaking research on the occurrence in humans, of cell receptors for susceptibility to HIV. We collaborated with Moritz Van Vuuren from South Africa on the occurrence of feline retroviruses in African big cats. We also collaborated with Steve Osofsky and his wife, who at the time were wildlife veterinarians working in Botswana. Now Steve is the Director of Wildlife Health Policy at the Wildlife Conservation Society and is trying to save Africa's wildlife using modern economic strategies www.wcs-ahead.org. Years later, to experience these magnificent cats and other
The great migration of wildebeest & zebra in the Serengeti
The crossing of the crocodile infested Mara River. Photos- Dr. Hardy
animals, including the great migration of wildebeest and zebra in their natural environment, was truly inspiring. Our trip also brought us to the Olduvai Gorge site where the Leakey's discovered some of the earliest hominin fossils relating to the evolution of humans. It was very moving to be actually standing at this scientifically historic site.
Olduvai Gorge- Tanzania and Louis Leakey
Origin of Humans:
East Africa, and possibly the Olduvai Gorge area in Tanzania, is the site for the origin of humans and cats. It is better-known as 'The Cradle of Mankind" and it was excavated by Louis and Mary Leakey in the 1950s.
Dr. Hardy at the Olduvai Gorge, Tanzania, the multilayer site of early hominin habitation from where present day humans evolved.
Deposits exposed in the sides of the gorge cover a time span from about 2.1 million to 15,000 years ago. They have yielded the fossil remains of more than 60 hominins (members of the human lineage), providing the most continuous known record of human evolution during the past 2 million years. One theory proposes that as the African climate changed and became drier, apes and hominins came out of the forest to scurry upright in the grassland savannas in search of food.1-2 As humans continued to evolve they spread to eventually settle in the Fertile Crescent, a curved area encompassing the Middle East- parts of Iraq, Syria, Lebanon, Jordan, Israel, and northern Egypt. The area was known as the Cradle of Civilization and the birthplace of agriculture, urbanization, writing, trade, science,
Fertile Crescent- green shaded area.
and organized religions (Christian, Jewish, and Muslim). The area was first populated in 10,000 BCE when agriculture and domestication of animals began.
Origin of Cats:
Felidae is the biological family of cats; a member of this family is called a felid. The first felids emerged during the Oligocene, about 25 million years ago. The most familiar felid, the domestic cat, first became associated with humans about 10,000 years ago. The family also includes all other wild cats, including the big cats. Existing felids belong to one of two subfamilies: Pantherinae (which includes the tiger, lion, jaguar, and leopard), and Felinae (which includes the cougar, cheetah, lynx, ocelot, and the domestic cat).3,4
Evolution of cats, Reference 3
The radiation of modern felines began with the divergence of the Panthera lineage. From this common ancestor all the big cats emerged 6.4 million years ago—lions, jaguars, leopards, tigers, snow and clouded leopards. They were quickly followed by three Asian species and three African species. The final feline to appear was the domestic cat, which emerged between 6.2 to 6.7 million years ago.
Domestic Cats: Domestic cats were derived from at least 5 founders of Felis silvestris, the European wild cat (Figure - courtesy Wikipedia), and humans dispersed their descendents throughout the world.3,4 Dogs and farm animals were domesticated before cats, and cats appear to have been domesticated about 9,500 years ago to control rodents that were feeding on grain storage sites.
Male lions, Photo- Dr. Hardy
Lions: Lion fossils trace to the Late Pliocene in Eastern Africa and the Early Pleistocene in Eastern and Southern Africa coincident with the flourishing of grasslands, 2–1.5 million years ago.5
By the Mid Pleistocene (500,000 years ago), lions occupied Europe and by Late Pleistocene, 130,000–10,000 years ago) lions had the greatest intercontinental distribution, excluding humans, for a large land mammal, ranging from Africa into Eurasia and the Americas. Lions were eliminated from Europe 2,000 years ago and within the last 150 years from the Middle East and North Africa. Today, there are less than 50,000 free-ranging lions living only in sub-Saharan Africa and the Gir Forest, India.
Cheetahs: Cheetahs evolved about 5.5 million years ago along with the golden cats and pumas. The cheetah (Acinonyx jubatus) is a large feline (family Felidae, subfamily Felinae) inhabiting most of Africa and parts of the Middle East. It is the only surviving member of the genus Acinonyx. Cheetahs are inbred and have unusually low genetic variability.6 Dr. O'Brien's Book on Cheetah Evolution
As Steve O'Brien has discovered and explained elegantly in his excellent book "Tears of the Cheetah," cheetahs have evolved through 2 bottlenecks where their genetic pool was very small resulting in little genetic diversity in the present day cheetahs.6
Female leopard- Photo-Dr. Hardy
Leopards are felids in the genus Panthera. The last common ancestor for animals in this genus is generally believed to have lived about 6.5 million years ago. Leopards appear to be related to lions, tigers, snow leopards, jaguars, and clouded leopards.3
The Pathogens:
African wild cats and their pathogens evolved together. Endogenous retroviruses were transmitted across species and then evolved in their new feline species. FIV-like viruses evolved in many African, and other wild cats and became non-pathogenic in these cats.7-14 Unlike FIV, the human HIV lentivirus derived zoonotically from chimps recently, has caused a worldwide epidemic killing millions of people. Bartonella is also found in several species of African wildcats and seems to have evolved separately in them. Although not a feline pathogen, the canine distemper virus killed many lions in the Serengeti in the 1990s and bovine TB continues to take its toll on African lions.15,16
FeLV: To date, no FeLV has been found in any free ranging African wildcats although there have been several infected with FeLV while living in zoos.7-14 The endogenous FeLV sequences are present only in the members of the genus Felis. Similar sequences are found in rats whose ancestors must have infected an ancestor of domestic cats after they diverged from the rest of the cat family. Domestic cat DNA also harbors RD-114 endogenous sequences obtained from baboon ancestors in ancient Africa.
FIV: The FIV-like virus found in African cats (FIV-ple) is similar to the one we found in cougars in North America and quite different from the pet cat FIV.17 FIV is endemic in 9 Felidae and one Hyaenidae species.7-14 The prevalence varies depending on the geographic location and appears to have evolved along with each cat species. The virus is non-pathogenic in these African cats, much like we observed in the pumas in British Columbia, Canada.8-10 In collaboration with Steve Osofsky and Karen Hirsch we found 8/31 (26%) lions, 3/18 (17%) leopards, and 1/4 (25%) cheetahs infected in Botswana in 1996.8 In 2003, with Moritz Van Vuuren, we found FIV infection common in free-ranging lions in Kruger National Park, SA 18/22 (82%), Botswana 20/22 (91%), Zimbabwe 7/22 (32%) but in none of the 18 lions from Hluhluwe-Umfolozi, SA.10
Bartonella: Bartonella have evolved with their animal hosts (co-evolution) for millions of years. This group of bacteria has a fascinating history in veterinary and human medicine and most warm blooded animals are infected with one of the 26 species of Bartonella. Few studies have been done on the prevalence of Bartonella in free-ranging African big cats. One study found serologic evidence of exposure in 19/113 (17%) African lions and 23/74 (31%) cheetahs- the country of origin was not specified. 5% of 58 lions and 6% of 17 cheetahs were considered bacteremic by TaqMan PCR.18 The other study of 62 lions on a game ranch in South Africa found 18 (29%) were antibody positive by IFA.19
Origin of Zoonotic Pathogens:
Africa was and is a hot bed of human, animal, and microbe evolution and it is no wonder that many of our new zoonotic diseases are arising from animals on the African continent. HIV and Ebola virus are but two that have arisen from Africa and more will probably follow.
1. Summers, BA Climate Change and Animal Disease. Vet Pathol 46:1185-1186, 2009.
2. Gibbons, A. Human Evolution. How a Fickle Climate Made Us Human. Science 341:474-479, 2013.
3. Johnson, WE. et al. Late Miocene Radiation of Modern Felidae: A Genetic Assessment. Science 311:73-77, 2006.
4. Driscoll, CA, et al. The Near Eastern Origin of Cat Domestication. Science 317: 519-523, 2007.
5. Antunes A, Troyer JL, Roelke ME, Pecon-Slattery J, Packer C, et al. (2008) The Evolutionary Dynamics of the Lion Panthera leo Revealed by Host and Viral
Population Genomics. PLoS Genet 4(11): e1000251. doi:10.1371/journal.pgen.1000251
6. Menotti-Raymond, M, and O'Brien, SJ, Dating the genetic bottleneck of the African cheetah. Proc Natl Acad Sci USA, 90:3172-3176, 1993.
7. Brown, EW, Olmsted, RA, Martenson, JS and O'Brien, SJ. Exposure of FIV and FIPV in Wild and Captive Cheetahs. Zoo Biology 12:135-142, 1993.
8. Osofsky, SA, Hirsch, KJ, Zuckerman, EE, and Hardy, WD, JR. Feline lentivirus and feline oncovirus status of free-ranging lions (Panthera leo), leopards (Panthera pardus), and cheetahs (Acinonyx jubatus) in Botswana: A regional perspective. J. Zoo Wildl. Med. 27: 453-467, 1996.
9. VandeWoude S., O'Brien, S.J., Langelier, K., Hardy, WD, JR., Slattery, JP, Zuckerman, EE, Hoover, EA. Growth of lion and puma lentiviruses in domestic cat cells and comparisons with FIV. Virology 233: 185-192, 1997.
10. VAn Vuuren, M, STYLIANIDES, E, KANIA, SA, Zuckerman, EE and Hardy, WD. Evaluation of an indirect enzyme-linked immunosorbent assay for the detection of feline lentivirus reactive antibodies in wild felids, employing a puma lentivirus-derived synthetic peptide antigen. Onderstepoort Journal of Veterinary
Research 70: 1–6, 2003.
11. Munson, L., et al., Serosurvey of viral infections in free-ranging Namibian cheetahs (Acinonyx Jubatus). J Wildlife Dis 40:23-31, 2004.
12. Troyer, JL, et al., Seroprevalence and Genomic Divergence of Circulating Strains of Feline Immunodeficiency Virus among Felidae and Hyaenidae Species. J. Virol 79:8282-8294, 2005.
13. Roelke, ME, et al., Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lions. Virology 390:1-12, 2009.
14. Thalwitzer, S., et al., Seroprevalence to Viral Pathogens in Free-Ranging and Captive Cheetahs (Acinonyx jubatus) on Namibian Farmland. Clin Vaccine Immunol 17:232-238, 2010.
15. Roelke-Parker, ME, et al., A canine distemper virus epidemic in Serengeti lions (Panthera leo). Nature 379:441-445, 1996.
16. Michel AL, et al. Wildlife tuberculosis in South African conservation areas: implications and challenges. Vet Microbiol. 112:91-100, 2006.
17, Hardy, WD, JR, Zuckerman, EE and Langelier, K. Possible "trans-species" transmission of a feline lentivirus from Pumas (Felis concolor) to domestic cats (Felis catus). September 7-13, 1996, Abstract 335, AIDS Research and Human Retroviruses.
18. Molia, et al, Prevalence of Bartonella infection in wild African lions (Panthera leo) and cheetahs (Acinonyx jubatus). Vet Microbiol 20:31-41, 2004.
19. Pretorius, A-M, Kuyl, JM, Isherwood, DR, and Birtles, RJ. Bartonella henselae in African Lion, South Africa. Emerg Infect Dis 10:2257-2258, 2004.
Bartonella references can be obtained at: www.nlm.nih.gov/ or natvetlab.com
©National Veterinary Laboratory, Inc., 2013


text:
At the time this project was conceived, there was no other Power Generation Project
planning in Bhavnagar District as well as in the neighboring Districts.
Demand of Saurashtra region at the time was more than 1500 MW.
Availability of Lignite reserve for Power Project in the District: 130 MMT.
Hence, setting up of this project with capacity as 500 MW (2 X 250 MW) was planned.
No Power Generation Project in Bhavnagar District as well as neighboring Districts
Demand of Saurashtra region more than 1500 MW
Lignite reserve for Power Project in the District : 130 MMT
Designed Capacity of Power Project 500+20%MW
Project Statutory Clearances:
Last Updated Date :
© Bhavnagar Energy Company Limited. All Rights Reserved.
Privacy Policy

subset: commoncrawl


text:
Project manager Assistant
INNOV8, Paris
- Marketing Communication
- App testing
- Backoffice management
- Price Collector
- Phoning
Chloe is a student at the INSEEC Business School Paris Campus, in sandwich course in a digital marketing compagny where she develops an App that presents fashion luxury products. Chloe is rigorous, dynamic and creative. She has many skills like customer management relationship, and marketing communication strategy focused on social networks. She is a native french speaker but she has an advanced level in english. Finally, Chloe is very passionate about fashion and luxury industry.
Digital Marketing specialisation
Sport study with classical dance ballet "Lyon Ballet"
English ( B2),(Italian ( B1)
Pack Office (Excel, Power point, Word)


text: It's been a decade since NASA's Lunar Prospector satellite gave tantalizing hints—in the form of unexpectedly sparkly reflections—that the Moon's poles may have frozen water at or near the surface, but new data from a Japanese satellite looks like it's quashed the rumor. Kaguya's been in space since late last year, but it's now trained its very highly sensitive cameras, that can see even into the near darkness inside polar craters, on the same spot of the moon Prospector saw. And all it found was dull lunar soil. There may still be water buried beneath the surface of course, but this discovery may be bad news for hopes of using plentiful hydrogen for fuel cells when we go back to the Moon in a decade or so. [NewScientist]


text:
WASHINGTON (Reuters) - Women with a family history of breast cancer but who test negative for two genetic mutations commonly linked to it still have a very high risk of developing the disease, Canadian researchers said on Monday.
These women are four times more likely to develop breast cancer than the average woman, translating to roughly a 40 percent lifetime risk of getting the disease, according to researchers led by Dr. Steven Narod of the University of Toronto.
"I think we were surprised that it was that high. But certainly at that level of risk, one would think about preventive measures," Narod, who presented the findings at a meeting of the American Association for Cancer Research, said in a telephone interview.
Those measures may include magnetic resonance imaging, or MRI, exams of the breast, considered a more sensitive screening test for breast tumors than a mammogram, Narod said. The women also may want to consider the drug tamoxifen as a preventive measure, Narod said.
The study involved 1,492 Canadian women with an average age of 48 who did not have mutations in either of two breast cancer susceptibility genes — BRCA1 and BRCA2.
The women came from families with a history of breast cancer — either two or more cases of breast cancer among close relatives under age 50 or at least three cases among close relatives of any age. Narod said it had been unclear exactly what risk breast cancer posed to women in these circumstances.
Most women who get genetic testing for the BRCA1 and BRCA2 are not found to have these abnormalities.
While BRCA1 and BRCA2 mutations also are associated with a higher risk for ovarian cancer, the women in this study did not have a greater likelihood for that ailment.
Narod said the lifetime risk of breast cancer estimated for these women compared to the roughly 80 percent lifetime risk for women with the BRCA1 or BRCA2 mutations.
The likelihood that a woman's breast cancer is linked to the BRCA1 and BRCA2 genes is particularly high among women with an Ashkenazi, or Eastern European, Jewish background.
Each year, breast cancer kills about 465,000 women worldwide and 1.3 million develop it, according to the American Cancer Society.
Editing by Bill Trott


text:
Norwalk, CT Angel Commercial L.L.C. completed the sale of 173 Main St., a 17,500 s/f retail/warehouse building, for $1.95 million, handled by two of its senior brokers.
Lester Fradkoff, senior vice president, represented the seller, Brandman Realty LP, and Brett Sherman, CCIM, senior vice president, represented the buyer, Servpro.
"We brought both parties together and executed a deal before the property even made it to the market," said Fradkoff. "Servpro will be occupying the entire building and consolidating their Stamford and Bridgeport locations," states Sherman."
Headquartered in Gallatin, Tenn. Servpro is a franchiser of fire and water cleanup and restoration franchises in the United States and Canada. The franchise system provides localized services as well as large-scale disaster recovery. With over 1,700 franchises nationwide, Servpro is a leader in the restoration industry.
Angel Commercial is a full-service real estate brokerage firm headquartered in Fairfield County. The company specializes in the acquisition, disposition, and leasing of office, industrial, multi-family and retail properties on a local and national level.


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Enki is Humanity`s Father. Enlil known as Jehovah wanted humanity DEAD 1, 2 & 3
Enki is Humanity`s Father. Enlil known as Jehovah wanted humanity DEAD 1
Enki is Humanity`s Father. Enlil known as Jehovah wanted humanity DEAD 2
Uploaded on Oct 5, 2010
In India, the "nagas" were the serpent gods/goddesses. In the Americas there was Quetzlcoatl (Thoth). The entire world has worshipped the serpent for its wisdom, but ironically, it was not really about snakes at all – unless you feel you have to "guess" what a snake is up to! Why was the snake chosen? For its cleverness, ability to survive in the harshest of environments, and again, its shape resembling the flow of energy up the spine. And perhaps because it naturally instilled a bit of caution or awe in people.
The serpent always represented wisdom, life and healing. It was not considered an evil being until much later days in the Christian and Jewish religions. Enki transferred the power of the caduceus to his son Ningishzida (Thoth), the healing god, and then to others of his family because it was a code for the bloodline of Enki's heritage.
The story of the serpent becoming an evil symbol began with the wars between Enki (Adonai) and his Pleiaden brother, Enlil (Jehovah). These conflicts began at birth and had to do with birthright to the royal throne of the Nibiruan civilization in which their father, Anu, was the leader. This story later was reflected in Cain and Abel, and all the stories throughout your times of brothers competing for power.
Although there was love between Enki and Enlil, they were used by Anu for his own power game. From Mr. Sitchen's Earth Chronicles Events Before the Deluge.
Years Ago:
450,000 On Nibiru, a distant member of our solar system, life faces slow extinction as the planet's atmosphere erodes. Deposed by Anu, the ruler Alalu escapes in a spaceship and
finds refuge on Earth. He discovers that Earth has gold that can be used to protect Nibiru's atmosphere.
445,000 Led by Enki, a son of Anu, the Anunnaki land on Earth, establish Eridu -Earth Station I – for extracting gold from the waters of the Persian Gulf.
430,000 Earth's climate mellows. More Anunnaki arrive on Earth, among them Enki's half-sister Ninhursag, Chief Medical Officer.
416,000 As gold production falters, Anu arrives on Earth with Enlil, the heir apparent. It is decided to obtain the vital gold by mining it in southern Africa. Drawing lots, Enlil wins command of Earth Mission; Enki is relegated to Africa. On departing Earth, Anu is challenged by Alalu's grandson.
400,000 Seven functional settlements in southern Mesopotamia include a Spaceport (Sippar), Mission Control Center (Nippur), a metallurgical center (Shuruppak). The ores arrive by ships from Africa; the refined metal is sent aloft to orbiters manned by Igigi, then transferred to spaceships arriving periodically from Nibiru.
380,000 Gaining the support of the Igigi, Alalu's grandson attempts to seize mastery over Earth. The Enlilites win the War of the Olden Gods.
300,000 The Anunnaki toiling in the gold mines mutiny. Enki and Ninhursag create Primitive Workers through genetic manipulation of Ape woman; they take over the manual chores of the Anunnaki. Enlil raids the mines, brings the Primitive Workers to the Edin in Mesopotamia. Given the ability to procreate, Homo Sapiens begins to multiply.
200,000 Life on Earth regresses during a new glacial period.
100,000 Climate warms again. The Anunnaki (the biblical Nefilim), to Enlil's growing annoyance marry the daughters of Man.
75,000 The "accursation of Earth" – a new Ice Age-begins. Regressive types of Man roam the Earth . Cro-Magnon man survives.
49,000 Enki and Ninhursag elevate humans of Anunnaki parentage to rule in Shuruppak. Enlil, enraged. plots Mankind's demise.
13,000 Realizing that the passage of Nibiru in Earth's proximity will trigger an immense tidal wave, Enlil makes the Anunnaki swear to keep the impending calamity a secret from Mankind. Events After the Deluge. 11,000 Enki breaks the oath, instructs Ziusudra/Noah to build a submersible ship. The Deluge sweeps over the Earth; the Anunnaki witness the total destruction from their orbiting spacecraft.
Enlil agrees to grant the remnants of Mankind implements and seeds; agriculture begins in the highlands. Enki domesticates animals.
10,500 The descendants of Noah are allotted three regions. Ninurta, Enlil's foremost son, dams the mountains and drains the rivers to make Mesopotamia habitable; Enki reclaims the Nile valley. The Sinai peninsula is retained by the Anunnaki for a post-Diluvial spaceport; a control center is established on Mount Moriah (the future Jerusalem).
Enki is Humanity`s Father. Enlil known as Jehovah wanted humanity DEAD 3
Jack Barranger
Jack Barranger is a retired professor of Critical Thinking and English at the College of the Sequoias in Visalia, California. His first book, Knowing When to Quit, became a best-seller in the field of self-help. When he took the problem of people finding themselves in unwanted situations to a deeper level, the book Past Shock was the result. Jack is known to have been one of the most innovative and original college teachers who consistently challenged students in extremely rewarding ways. His books go beyond what he could teach in the classroom except when, on occasion, he could challenge students in Critical Thinking with the many alternative views that he has so carefully researched and explored. With a background in theology combined with an intense desire for the truth, Jack is one of the few pioneers to expose the origins of religion– origins that were previously shrouded in the past or simply covered up by modern authorities.
The Annunaki & Humankind
Date: 07-06-08
Host: George Noory
Guests: Jack Barranger
Appearing during the middle two hours, retired Professor Jack Barranger picked up where Zecharia Sitchin left off to discuss how the Annunaki (alleged ET beings who came to Earth in antiquity) created humanity as a slave race to mine gold for them. These beings, thought of as gods, conditioned humanity to remain ignorant and slave-like, he suggested.
A series of events and fears were created by the Annunaki to keep humans obedient and unquestioning, said Barranger. These included the ousting of Adam & Eve from the Garden of Eden, the destruction of the Tower of Babel, and the threat of hell.
Other "past shocks," included the Great Flood and the passage of Mars close to Earth, both of which created cataclysmic circumstances that left an imprint on mankind. The Annunaki, he noted, left Earth around 800 BC.
The last hour of the show featured Open Lines.
Uploaded on Aug 22, 2010
The Official Web Site of Zecharia Sitchin
Zecharia Featured in The New York Times
Historic Evidence : Robert Sepehr's research into the Earth's past geology
helps to establish and demonstrate a 3600 year pattern of cataclysm on Earth.
http://www.planetxvideo.net/observati… Noted Researchers : Researchers and Proponents
http://www.planetxvideo.net/observati… Anunnaki/Nephalim : Who were the Anunnaki?
http://www.planetxvideo.net/bibleprop… Biblical Prophecy : Planet X in Biblical Prophecy
http://www.youtube.com/user/clixster PX on YouTube
http://www.planetxvideo.net/nancy.php Nancy Lieder
http://www.planetxvideo.net/lloyd.php Lloyd Pye
http://www.planetxvideo.net/jason.php Jason Martell
http://www.planetxvideo.net/mark.php Mark Hazlewood
http://www.planetxvideo.net/james.php James McCanney
http://www.planetxvideo.net/andy.php Andy Lloyd
http://www.planetxvideo.net/robertino… Robertino Solarion
http://www.planetxvideo.net/cody.php Cody Jordan
http://www.planetxvideo.net/popa.php Dr. Radu Popa
http://www.planetxvideo.net/pipkin.php Dr. Bernard Pipkin


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Donate to the NCCN Foundation
By Rashmi Kumar, PhD, Oncology Scientist/Senior Medical Writer
On Friday, September 20, and Saturday, September 21, 2013, the National Comprehensive Cancer Network® (NCCN®) hosted its 8th Annual Congress: Hematologic Malignancies™ at the Marriott Marquis in New York, NY.
Moderated by Andrew D. Zelenetz, MD, PhD, Memorial Sloan-Kettering Cancer Center, chair of the NCCN Guidelines panel for Non-Hodgkin's Lymphomas (NHL), this year's Congress focused on the new approaches to patient management and updates that have been incorporated into the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for hematologic malignancies and associated supportive care regimens. Nearly 700 oncology professional attended the event, which featured expert speakers representing the NCCN Member Institutions.
Friday's session commenced with a welcome reception for attendees, followed by opening remarks from Dr. Zelenetz.
In the opening presentation, "Genomics and the Era of Personalized Medicine", Ross Levine, MD, Memorial Sloan Kettering Cancer Center, presented data on genomic profiling of leukemias and talked about the implications of this genomic data in personalized medicine. Dr. Levine shared data from recent whole genome sequencing and gene array based studies that have identified novel commonly recurring disease alleles/mutations in acute myeloid leukemia. Clinical and biologic relevance of these novel disease alleles is yet to be determined.
The presentations following Dr. Levine's presentation focused on management and molecular monitoring of leukemias such as Chronic Myeloid Leukemia (CML) and Acute Lymphoblastic Leukemia (ALL). In the presentation, "TKI Therapy in CML: Practical Considerations," Michael Millenson, MD, Fox Chase Cancer Center, discussed the challenges related to management of patients with CML on tyrosine kinase inhibitor (TKI) therapy, such as selection of optimal agents, determining patient prognosis, and appropriate monitoring strategy while on therapy. Dr. Millenson also outlined strategies for maximizing adherence and management of side effects of TKI therapy.
Neil P. Shah, MD, PhD, UCSF Helen Diller Family Comprehensive Cancer Center, reviewed the data on the prognostic significance of monitoring molecular response to TKI therapy in patients with CML. Dr. Shah pointed out that, in both CML and ALL, rapid molecular response is associated with superior outcomes; however, standardization of molecular monitoring is essential to reliably interpret and apply molecular test results.
Friday's session concluded with a presentation by Patrick A. Brown, MD, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, titled, "Management of Ph-positive ALL." Dr. Brown outlined the current standards of care for first-line treatment of Ph-positive ALL in the adolescent, young adult, and adult patients, pointing out that, although the optimal duration of TKI therapy is not defined, incorporation of TKIs has markedly improved outcomes of patients with Ph+ ALL.
Day two of the Congress included 14 presentations from the country's leading experts, including the latest advancements and best practices across the continuum of care for hematologic malignancies.
"Management of Relapsed/Refractory Multiple Myeloma," presented by Kenneth C. Anderson, MD, Dana-Farber/Brigham and Women's Cancer Center, included review of data leading to the approval of pomalidomide and carfilzomib as therapies for relapsed/refractory myeloma. Dr. Anderson also described the future landscape for treatment of Myeloma with the exciting potential of new classes of agents, including vaccine therapy, monoclonal antibodies, and new rationally based combination therapies to further improve and extend the lives of patients with Myeloma. Dr. Anderson concluded his talk, noting that genome sequencing efforts are underway to define the basis for the evolution of underlying relapse, identify new targets, molecularly classify a patient, and personalize therapy.
Following Dr. Anderson's presentation, Noopur Raje, MD, Massachusetts General Hospital Cancer Center, discussed the latest advancements in the management of bone health in Multiple Myeloma, which, she noted, remains a major source of morbidity and has an impact the quality of life in this patient population. After discussing how best to assess the skeletal–related events using the standard imaging techniques, Dr. Raje outlined the benefits and risks of bisphosphonates and surgical options for treatment of myeloma-related bone disease. She overviewed clinical trial data showing the equivalence of pamidronate versus zoledronic acid and the survival advantage with the use of zoledronic acid compared with clodronate, as well as the potential role of denosumab in this setting.
The next two talks focused on Myeloid Leukemias. Martin S. Tallman, MD, Memorial Sloan Kettering Cancer Center, discussed the current treatment approaches in acute promyelocytic leukemia (APL). In the presentation, "Clinical Genomics in Myeloid Malignancies (AML)," Richard M. Stone, MD, Dana-Farber/Brigham and Women's Cancer Center, summarized the importance of genetic analyses in assessing prognosis of patients with de novo AML and in choosing post-remission therapy. Dr. Stone added that it may also help enroll patients in appropriate clinical trials since there are many ongoing and planned trials centered on patients with certain molecular features.
Steven P. Treon, MD, PhD, Dana-Farber/Brigham and Women's Cancer Center, in his presentation, "Diagnosis and Management of Waldenström's Macroglobulinemia/Lymphoplasmacytic Lymphoma," introduced the audience to the treatment approach and new findings in management of this B-cell-related disease. He discussed clinical data on currently available combination therapies and presented emerging data on the new treatment options potentially approved in the near future for the management of this disease, including ibrutinib and carfilzomib-based regimens. In closing, Dr. Treon shared new molecular findings of a commonly recurring mutation in patients with Waldenström's Macroglobulinemia, called MYD88 L265P, that now represents a novel pathway for differential diagnosis and targeted therapy for this disease.
In the presentation, "Current Practices in NHL Therapy: Focus on Marginal Zone Lymphomas," Leo I. Gordan, MD, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, explained that the subtypes of various marginal zone lymphomas (MZLs), such as gastric MALT, nodal MZL, and splenic MZL, are all related clinical entities and their differential diagnosis is not straightforward. Dr. Gordan also outlined the diagnosis and treatment options for the major subtypes of MZLs.
In addition to treatment of various hematological malignancies, attendees learned the latest practices in supportive care, management of patient symptoms, and palliative care. In the presentation "Supportive Care Considerations in the Treatment of NHL," Dr. Zelenetz pointed out that there are several important areas for supportive care considerations in patients with NHL including, but not limited to, management of tumor lysis syndrome (TLS), viral reactivation, febrile neutropenia, chemotherapy-induced thrombocytopenia, and role of erythropoiesis-stimulating agents and growth factors.
Kim Noonan, MS, RN, ANP, AOCN, Dana-Farber/Brigham and Women's Cancer Center, summarized the risk factors for development of cancer therapy-induced nausea and vomiting (CINV) and the current standards in anti-emesis management. Ms. Noonan outlined the risk factors for CINV, particularly the relationship to the specific therapy used to treat cancer patients, and discussed the importance of providing anti-emetic prophylaxis to prevent or control CINV.
Susan G. Urba, MD, University of Michigan Comprehensive Cancer Center, began her presentation, "Palliative Care for Hematologic Malignancies," by highlighting that newly diagnosed patients with hematological malignancies have numerous distressing symptoms and controlling these is of paramount importance to improve symptoms, quality of life, and patient satisfaction, with reduced caregiver burden. Dr. Urba shared data indicating patients with hematological malignancies are often referred to palliative care much later during the course of treatment than those with solid tumors; and she stressed the importance of integrating supportive care measures with curative treatment for the management of patients with hematological malignancies.
The final presentation of the day, "Alternative Stem Cell Sources in Transplantation," delivered by Richard J. Jones, MD, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, included discussion on the haploidentical stem cell transplantation (SCT), a technique that involves use of hematopoietic stem cells from relatives who are partially matched. Dr. Jones noted that the biggest advantage of this technique is of rapid and near universal donor availability; however, he noted its association with high rates of graft rejection, severe graft-versus-host disease (GVHD), and infectious complications. Dr. Jones shared exciting new data on how the use of high-dose cyclophosphamide post-transplant significantly inhibits GVHD associated with haploidentical SCT, potentially making this an excellent therapeutic alternative for patients lacking HLA-matched sibling donors or fully matched unrelated donors.
The Congress concluded with closing remarks from Dr. Zelenetz.
For more information about the NCCN 8th Annual Congress: Hematologic Malignancies™ visit NCCN.org.
Look for further announcements in upcoming editions of NCCN eBulletin regarding continuing education opportunities, based off of the presentations from this year's Congress, which will be available in the coming months.
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Google expected to unveil its HTC-made Nexus 9 tablet on October 8
According to the latest rumors, Google will finally announce its new Nexus 9 tablet at a media event on October 8. Various media are being invited to an event with the title "Double Exposure".
This event falls in place with HTC's event, where the company is expected to unveil a GoPro-like camera, as well as a new super selfie smartphone - also teasing Double Exposure. What will be powering the Nexus 9? For starters, NVIDIA's more-than-capable Tegra K1 processor, 3GB of RAM, a 9-inch 1920x1080 display, 16GB of flash storage, 100GB of Google Drive storage and much more.
The biggest part of the Nexus 9 will be its 'tube-shaped' 16-megapixel camera, and possible waterproof abilities. We will also see Bluetooth and Wi-Fi connectivity, as well as the ability to control the 9-inch slate from an Android- or iOS-powered smartphone with an app developed in-house by HTC.


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Oakville, Ontario
Rebecca Street refers to the property formally known as Surrey Park, located at Dorval Drive and Rebecca Street in the town of Oakville, Ontario. Canada Lands Company acquired the Rebecca Street property from the Department of National Defence (DND) in June 2010.
This 16.2-acre (6.58 hectare) property is situated on the north-west corner of Dorval Dr. and Rebecca St., not far from scenic Lake Ontario.
The lands have been designated as Low Density Residential, Special Policy Area in the Town's Official Plan, "Livable Oakville". To learn more about the land use designation for the Rebecca Street site please visit the Town of Oakville's official website.
The Rebecca Street redevelopment is Canada's first Pre-Certified LEED for Neighborhood Development Plan, under the first non-pilot LEED ND rating system. The plan proposes 62 single detached lots and approximately 62 condominium townhome units, along with a 1.2 acre central park. The homes will be LEED for Homes certified.
Approval of the plan of subdivision and rezoning applications was awarded in spring 2012, and LEED ND certification was achieved in spring 2013. Site servicing has been completed and new home sales and construction by Fernbrook Homes is ongoing.
For information about homes for sale please visit the on site sales center or follow this link:
Canada Lands Company is pleased to announce that Fernbrook Homes has been selected to construct the homes in the Rebecca Street development. Fernbrook Homes has completed many outstanding developments in Oakville and the GTA; many of which you can view at their website here.
Canada Lands Company is issuing a Request for Proposal (RFP) for the purchase of serviced lots and blocks in the Rebecca Street development. Click here for the RFP Notice.
The Town of Oakville has approved the Draft Plan of Subdivision and rezoning application for the Rebecca Street subdivision. Click here for the approved Draft Plan of Subdivision.
The final plan includes 62 single detached lots and approximately 62 condominium townhome units along with a 1.2 acre central park.
The Town of Oakville has issued the attached notice dated May 11 2012 advising of the recommendation report on the development application being brought to the May 22, 2012 Planning and Development Council meeting.
Click Here for a link to the Town's web site to access the May 22 2012 meeting agenda and supporting documentation.
Click Here for the development application information on the Town's web site.
The Town of Oakville scheduled a statutory public meeting to receive additional comments on Canada Lands' application. A number of residents were present to share comments to Council. Town planning staff's recommendation was to receive all comments for consideration in the ongoing review of the development applications. Click here for meeting notice.
Canada Lands Company representatives were in attendance to field and answer questions on the development applications at the Town of Oakville's public information meeting. Information panels as well as a slide presentation were shown to residents, both of which can be found amongst the Project Information documents.
Canada Lands Company submitted its formal development applications for the Rebecca Street Property plan of subdivision and zoning amendment to the Town of Oakville on Sept 29 2011. Oakville has posted the application and the supporting documentation on its municipal web site. The Town has also posted a meeting notice for its scheduled Public Information Meeting to be held on Nov 17 2011 at 7pm at the St James Catholic School at 255 Morden Rd.
The development proposal consists of 66 single family detached lots and approximately 59 condominium townhouse units. A 1 acre central public park area that is surrounded with public streets will be highly visible and accessible to the neighbourhood residents. An efficient network of streets and sidewalks will integrate the site with the surrounding community and encourage walking.
Canada Lands Company has registered the project under the LEED ND (Leadership in Energy and Environmental Design for Neighbourhood Development) program and is proposing to achieve certification of the development. Various components of the plan have been guided by these LEED ND standards in order to achieve a more sustainable development as contemplated by public planning objectives and current land use policies.
Some examples of the LEED ND sustainable components that are proposed to be implemented include: pedestrian friendly streetscapes and sidewalks on both sides of streets to encourage walking; reduced street light energy consumption; recycled content in infrastructure; reduced heat island effects and reduced water and energy use in the houses. Additional information on the LEED ND program can be found at the Canadian Green Building Council website.
Canada Lands Company held an extremely well attended community information session at St. James Elementary School last night. Information was presented on the company's proposed concept for the redevelopment of the Rebecca Street lands and the attendees were provided an opportunity to ask questions as well as offer their comments and concerns for Canada Lands Company's consideration.
For those unable to attend last night's session the Power Point presentation is available for viewing via the link shown in the Project Information box to the left. To view the information panels that were displayed please click here.
Canada Lands Company would like to invite you to a Community Information Session for their Rebecca Street development. The session will take place May 31st at St. James Elementary School (255 Morden Road) from 7:00 p.m. - 9:00 p.m. with the formal presentation beginning at 7:15 p.m.
Canada Lands Company held a very well attended community information session at the Oakville Public Library last night. This session allowed the public to learn about Canada Lands and its approach to their projects as well as to provide their initial input into the redevelopment of the Rebecca Street lands.
The Power Point presentation is available for viewing via the link shown in the Project Information box to the left. To view the information panels that were displayed please click here.
Canada Lands Company has granted the Oakville Fire Department permission to access the Rebecca Street site for training purposes. The fire department will use this opportunity to practice their skills in order to maintain their response capabilities at the highest level for the residents and visitors to the municipality.
Rebecca Street
Oakville, Ontario
David Anselmi


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Social MediaHere's how to find us on Facebook, YouTube, Twitter, Instagram, and other social media sites.
Press Kit
If you are a member of the press looking for basic facts and information about the monument, here you will find information highlighting the main features of WWII Valor in the Pacific National Monument and links to galleries of high resolution photos for use by the media.
Contact Public AffairsHere's how to get in touch with us.
Last updated: June 9, 2017


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|One of the many views on our walk home from shopping on the Left Bank.
|My Trip To Paris With My Daughter
by Nina Griscom
My daughter, Lily, has been to Paris many, many times, between the ages of 5 and 8, when her grandfather Felix Rohatyn served as American Ambassador to France under President Clinton (2007 to 2000).
Of course I remember those 3 years very well. It was pure magic and right out of a storybook. My memories could fill many volumes. But that is for another blog and probably only when I am close to death!
Lily had forgotten all those childhood years and asked me to take her to Paris during her Spring break from Trinity College this past month.
I was somewhat horrified that she had no memory of all those wonderful times. But nevertheless, I wanted to tweak her memory and to spend a few mother/daughter days with her in this beautiful city where I have spent so much time over the years of my life.
We flew on my favorite airline, British Air/Open Skies. BA is one of the few remaining proper airlines (as opposed to flying cattle cars posing as carriers) and knows how to give great service. I always opt for Biz Bed or Premium Economy, which is a close and less expensive equivalent to Business Class seats on other airlines.
When we awoke, it was rainy and grey in Paris. Nothing new about that. We had packed two tiny umbrellas which one should always carry to Europe.
A dear friend had kindly loaned us her apartment in the 1st arrondissement; walking distance from the Rue Saint-Honoré. There's nothing better than staying in a Paris apartment if you want to experience authentic daily life.
Elevators (closer to small mechanical crates) in Parisian apartment buildings are small and do NOT accommodate large suitcases or heavy weight, so Lily and I thumped our roller bags up the staircase to the 1ere étage apartment.
I was happy that she seemed ready to roll and wasn't too jet lagged, so after unpacking we grabbed a taxi over to the Left Bank for lunch at Brasserie Lipp.
Lipp is the quintessential Parisian brasserie, and I had many "festive" meals there when I was a model, in the late '70s and early '80s with the journalists and photographers who were my friends at the time, such as William Connors and Benno Graziani.
|When you go to Lipp, you need to ask for a table on the ground floor. The wait staff can have major attitude here and are not fond of tourists, whom they regularly dispatch to the 2nd floor; the realm of isolated Purgatory! The ground floor is where the locals dine, and where the action is. And don't bother trying to speak French. The waiters all speak better English than you do.
After settling into a lovely banquette (on the ground floor), and ordering two Kirs, we looked at the menu: Pig's feet, Rognons (kidney's), Cerveaux, (brains), Brandade (mousse of cod), etc. After all this was a brasserie.
|Lily chose this moment to inform me that she hated French food, and wanted pasta. PASTA! Boy was this ever the wrong place for pasta. I tried to coax her into a Foie de Veau (calves liver). No way. She settled for steamed asperges, and a salad along with half the basket of fresh bread. What to say!
I ordered the Oeufs en Gelée (eggs in aspic), and the Brandade; classic brasserie dishes. The food was fine, not great. But that is Lipp. Lily was thrilled when Owen Wilson appeared next to us, asking for a table. All of a sudden she thought Lipp was fabulous. What a criteria!
|After lunch we walked along the side streets of the Left Bank that have all the boutiques and shops she wanted to look in: Rue de Bac, Rue de Sevres, Rue des Saints-Peres, Rue de Grenelle, Rue du Four, Rue de Cherche-Midi, etc. None of them are too long and all are worth visiting. The most exquisite lingerie (and the most chère) in the world is Sabbia Rosa, located at 73 Rue des Saints-Peres. A rainbow of silk and lace.
The French have a wonderful saying: Léche Les Vitrines, which literally translated to "licking the windows." But in Paris it means window shopping. So we did just that.
We walked several beautiful miles back to the Right Bank and our borrowed apartment, exhausted, but full of all the beauty that is Paris.
We took a brief nap, and then sorted ourselves out (meaning: two girls in the bathroom curling hair and putting on make-up) for what was to be our first grand culinary experience: dinner at Le Grand Véfour.
|Don't even think about dining before 8:30 or 9:00 PM in Paris or you will be looked at as a crazy American, the polite way of saying "heathen."
Le Grand Véfour (17 Rue de Beaujolais) is the Grand Dame of establishment restaurants in Paris, and comes with a wonderful 200-year social, political and culinary history as well as a sumptuously beautiful gilded dining room and haute cuisine, delivered by master chef Guy Martin (who is young and very handsome).
|My first visit to Le Grand Véfour was with my dear mother when I was 12 or 13. I will never forget having lunch with her there and dining on frog legs soufflé. It was unforgettable, and I wanted to have that moment with my daughter.
This is grand cuisine at its best, and most expensive! So prepare to let the moths out of your wallet.
Lily and I opted for all black simple elegance, (which was pretty much all we had packed). No need for crown jewels; just a good appetite and plenty of time. These days the dress code in Paris is Anything Goes.
We dined in splendor in a red velvet banquette that boasted Joséphine Beauharnais as a former occupant. I wish I could have been a fly on the velvet whilst she was dining!
In a final nod to complete hedonism, I allowed a dialogue with the fully turned out cheese trolley; a culinary refinement one does not often see in America or parts elsewhere. When I was asked what I would like, I responded, "I want all the strongest and creamiest ones that you have."
And it was manna from heaven! Despite the 5 pounds I gained, I have no regrets.
Lots more to come from my Paris diary.
|Visit Nina's blog HERE
Follow Nina on FACEBOOK


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A front-line researcher offers cutting-edge advice on preventing and slowing the progress of Alzheimer's.
Drawing on the most up-to-date information available on the disease as well as experiences from his clinical practice, Dr. Marwan Sabbagh, a leading expert in Alzheimer's research, translates the current ideas driving Alzheimer's treatment into practical information you can use to determine your risk and develop a prevention strategy. You'll find tools for assessing your personal Alzheimer's risk and "What You Can Do" sections to help you keep your brain and body healthy, plus information on the treatment of Alzheimer's and its complications.
There are an estimated 5.2 million people living with Alzheimer's in America today. If you or someone you love is at risk of developing the disease or wishes to slow its advancement, this book will give you vital information to help you reduce risk and safeguard health and quality of life.
From Publishers Weekly
This sobering review of the current research on and recommendations for Alzheimer's argues for identifying and combating risk factors decades before symptoms appear. Like other major conditions affected by obesity, high blood pressure and cholesterol levels, among others, Alzheimer's is growing at a rapidly increasing rate. Neurologist Sabbagh has been involved in many important Alzheimer's research trials and founded the Sun Health Research Institute's Cleo Roberts Center, a facility for studying age-related diseases, located in the geriatric community–dense Sun City area of Phoenix. He explains the mechanisms by which the brain undergoes devastating changes that manifest as Alzheimer's; the differences between age-related memory loss, Alzheimer's and other forms of dementia; and ways to assess genetic liabilities and risk factors from lifestyle choices. Although treatment goals and expectations for those with Alzheimer's are modest, Sabbagh says most risk factors can be offset well before retirement age through diet, physical and mental exercise, brain-specific supplements and, in some cases, medications that lower blood pressure and cholesterol levels, manage blood sugar and decrease inflammation. Sabbagh covers such concerns as exposure to toxic substances linked to neurological conditions and suggests many potent weapons to counteract development of brain plaque: omega-3 fatty acids, resveratrol, quercetin, folic acid, huperzine A, green tea and curcumin, among others. A guide to symptoms, diagnosis and treatment will prove helpful to patients and their families, while an overview of new drugs that could halt progression and possibly heal damaged brain cells offers hope for the future. (Feb.) Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.
Dear Sir,
I read with great interest in your comments. My husband was dx with dementia the alzheimers type. This was 3 years ago and he was put on Aricept for memory loss. He could not remember from one room to the other. I researched Coconut oil, B12, and tumeric. he started it 2 weeks ago, I am absoluty amazed by his progress. He walks better, and his memory is greatly improved. His cognitve skills are about an 8 on a scale from 1-10, before they were almost non exsistent. i have done a lot of the tests that the Dr. did and he can now do them,except the numbers. I j just wanted to share with you, what you are saying is very possible.
Thank you for taking your time to read this. If you have any questions please feel free to mail me with any questions you may have.


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Born and bred in the arts, Jacob was a gifted child of music and classically trained, developing over the years a belief in the 'renaissance man', the ability to create in whatever medium is appropriate to the creation. His philosophy succumbs to his whimsical spirit and delicate touch, harmonising with nature with his quiet complexities.
Jacob is deeply involved in experimental performance with his groups Koski and Bob Collective. He collaborates composing for film, dance and theatre. His visual exhibitions include exhibiting at Deem Gallery in Hong Kong, La Rondine Gallery in Italy and Hong Kong, Leonida Estate in Tuscany, Biennale di Soncino in Cremona, Barcelona SWAB art fair, and Axes Collective in Brussels. His collaborative Performance art has been exhibited at the Bagni di Lucca Art festival, Cartasia in Lucca, InTeatro in Polverigi, Fabrik in Potsdam and Saari Manor, Finland. He was also curator and project manager of the Bagni di Lucca Art Festival, Italy, for 3 years. His sound sculpture installations can be found at Bei Wu sculpture park in Germany. He will be exhibiting at the Australia House in London in June 2018. He has partaken in art residencies at the Saari Residence by Kone foundation in Finland, Mas des Graviers in France, Bei Wu Art Foundation in Germany and Villa Nappi in Italy.
At the age of 9 Jacob started his musical training. At 13 he started composition and improvisation at the Victorian College of Arts, Australia (VCA). At 15 he continued his studies of composition on a scholarship at the Interlochen Arts Accademy in Michigan USA. At 17 he started tertiary studies of composition at the VCA, Australia, while spending a lot of his time with students from the visual arts and sneaking into life drawing classes. Then to study sound production at TAFE.
Since then he has moved from life to life from London to Madagascar (where he met his wife Jaqueline), to Tuscany, to South East Asia and Europe while his love for photography became a serious practise. Through these new influences in his creative world and his long intimate relationship with visual art through his family and peers, he began to feel the connection between the many creative worlds. A new path became apparent – an exploration of how different practises can talk to each other and express with a common creative voice.
Ph: Italy +39 3351704683
email: email@example.com
Skype: jacob.cartwright


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Places galore to stay and play
Gansbaai boasts a wide range of luxury and casual accommodation to cater for a cosmopolitan market of eco-tourists, visitors and extreme outdoor adventurists all craving to see and experience the best that the area has to offer.
Whether you want to simply relax in a laid back fisherman's cottage at the beach to drink in the exquisite natural surroundings, or prefer 5-star pampering in a luxurious mountain resort – we have it all!
The almost 100 guesthouses, hotels, B&B's and lodges scattered in and around Gansbaai may differ greatly regarding the grade of grandeur and the specific activities and experiences that they offer, but they all have one thing in common: a spectacular setting in pristine coastal or mountainous landscapes of unsurpassed natural beauty. Let's face it – people come to Gansbaai to enjoy and experience the extraordinary environment and abundant rare plant and animal species that made this floral fynbos kingdom the world's number one whale watching and shark cage diving destination. All accommodation is aimed at providing guests with an ultimate and unique experience of the beauty and diversity of the area, its culture and its people.
Two scenic camping and caravan parks, both at the beach, provide a blissful setting for the outdoor crowd who prefer to rough it in nature. Adventurists and youngsters who travel on a shoestring budget can pick and choose from a wide variety of informal backpackers and self-catering apartments to provide in their basic needs. Tens of self-catering and luxurious guesthouses and B&B's provide guests with a taste of true Overberg hospitality and the best of homemade cuisine.
For those who want to indulge themselves in an ultimate combination of extremities – lavish luxury and comfort in an untouched wildlife extravaganza - there are a few eco-resorts in sublime nature reserves in the area that offer 5-star accommodation, cuisine and comfort in Edenic settings.
Whatever guests want - we have plenty of places to stay, play and enjoy the array of rare and riveting species and exquisite activities that this natural paradise has to offer.


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Antique Lumber
We stock a variety of dimensional lumber that has been naturally weathered, and preserved over time to reflect the full colour palette of beautiful silver greys to deep rich browns that you have come to expect from our 75 - 100 year old, antique, reclaimed barn wood. Every piece tells the specific story and heritage of the Canadian homesteaders pioneering spirit perfectly preserved in each hand picked, cleaned, and processed piece of history. Our customers use our antique, reclaimed lumber to create a myriad of incredibly innovative arts and craft pieces including mantels, shelving, signs, frames and furniture.
Call for pricing


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"Our Caring You'll Remember"
Trusted In-Home Nursing Services in the Durham Region
Compassionate, Professional Home Nursing, Personal, Palliative and Cancer Care
Whether you require private, personal care for your elderly or chronically ill loved one or for yourself after a surgery, Nightingale Nursing Registry Ltd. offers 24-hour in-home and at-hospital nursing services in the Durham Region. Dedicated to providing compassionate, professional care, our goal is to allow you to recover – or spend your final remaining days – within the comfort of your own home, surrounded by your friends and family. Our nursing services include:
- Geriatric or senior care
- Post-surgery care (wound care, mobility enhancement)
- Palliative care (flexible care plans – overnights, days, 24/7)
- Medication administration
- Transportation (shopping, banking, doctors' appointments, etc.)
- Home dialysis
- Pediatric care (overnights, new mother support, etc.)
Contact Us Today
Please contact us in Peterborough at 705-652-6118 or in Cobourg at 289-252-2121 to schedule a consultation and see how our registered nurses and registered practical nurses can be of assistance to you or your loved one.


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Bearing in mind various classmates´projects in their teaching practice, we were supposed to adapt web 2.0 tools either to "change" future plans or to reflect upon past ones : how we could have done lessons differently keeping students engaged and motivated.
Here is what Marcia and I thought about based on her last teaching practice. Instead of " writing letters"( students exchanged letters from 1 course to another), we adapt it by using LINOIT tool. We believe that it will be even more eye- catching and motivating to students.
We thought of grouping students in pairs and sent them a link in which they can have access to LINOIT. There, each pair can send and receive letters from each other and at the end of the final project, all students´work will be seen by the class.


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Can any one identify the secondary font on the above DVD cover (the part that says "Criterion Collection)." The "C" and the "O" are pretty unique but my own searches have been less than fruitful.
Much appreciated!
Way too small. Try FF
Permalink Submitted by Rainer Zerenko on 16 March 2011 - 3:28pm


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Moderator: Arkady
roseblood wrote:what style of music do they play?
This tour promises to be even more fun than last time, we've listened to our fans and took the step of asking promoters to make the age limit as low as it can be, or all ages wherever possible.
It sees our return to Ohio, and first live shows in Florida, Georgia, North Carolina, Colorado, Kansas, Utah, Texas and Arizona. It's also going to end with, finally, our first live show in Mexico City.
We're very happy to have, supporting on all dates, Sao Paulo Brazils Cansei de ser sexy/CSS, now signed to Sub Pop in the States.
see you in september xxxx
20 wed Miami, FL - Studio A 18
21 thu Orlando, FL - The Social 18
22 fri Atlanta, GA - Variety Playhouse AA
23 sat Asheville, NC - Orange Peel 18
25 mon Washington D.C. - 9:30 club AA
26 tue Philadelphia, PA - Theatre of Living Arts AA
27 wed New York, NY - Webster Hall 18
28 thu New York, NY - Webster Hall 18
30 sat Boston, MA - Avalon 18
01 sun Montreal, PQ - Metropolis AA
02 mon Toronto, ON - The Docks AA
04 wed Cleveland, OH - Beachland Ballroom AA
05 thu Columbus, OH - Wexner Center AA
06 fri Chicago, IL - Vic Theater AA
07 sat Lawrence, KS - The Granada Theatre AA
09 mon Denver, CO - Bluebird Theatre 16
10 tue Salt Lake City, UT - The Depot 21
12 thu Portland, OR - Berbatis Pan 21
13 fri Seattle, WA - Showbox AA
14 sat Vancouver, BC - Commodore Ballroom 19
16 mon San Francisco, CA - The Fillmore AA
17 tue Los Angeles, CA - John Anson Ford Amphitheater AA
18 wed San Diego, CA - Belly Up Tavern 21
20 fri Dallas, TX - Gypsy Ballroom 17
21 sat Austin, TX - Stubbs 18
22 sun Houston, TX - The Meridian AA
24 tue Tempe, AZ - The Clubhouse AA
27 fri Mexico City, MX - City Hall AA
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The Little Film Company will be showing footage in Cannes on its new thriller Sexy Evil Genius starring Buffy The Vampire Slayer veterans Seth Green and Michelle Trachtenberg alongside Anthony Michael Hall.
Shawn Piller directs from a screenplay by Scott Lew about a vengeful woman who lures several ex-boyfriends to a bar in downtown Los Angeles for a night of retribution. Katee Sackhoff, William Baldwin and Harold Perrineau Jr round out the cast.
Lloyd Segan of Piller/Segan/Shepherd produces with David W Higgins of Launchpad Productions and Mark Amin of Sobini Films. Sobini's Cami Winikoff serves as executive producer.
"Sexy Evil Genius is intimately compelling yet commercially appealing to a universal audience – a testament to the unique story brought to life by an outstanding cast," Robbie Little said. "For us, the film exemplifies the pedigree of picture we are committed to bringing to the international marketplace. We're excited for initial reactions to film footage in Cannes."
Little's Cannes sales slate includes the thriller Defiant starring Toni Collette and Dev Patel, Nights Of Cabiria remake The Days Of Mary starring Juliette Lewis, Elaine Constantine's music drama Northern Soul and Devil's Peak, the first in a thriller trilogy to star Sean Bean.
The company is also handling select territories on Dario Argento's official selection Dracula 3D starring Thomas Kretschmann, Asia Argento and Rutger Hauer.


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Increase Rug Doctor Cleaning Effectiveness By Utilizing Pre
Carpet cleaning is a pricey chore, with most business cleaning preparations priced at approximately $0.30 per ounce. This is identical case with pets as effectively and so they get contaminated because of your soiled carpet. To gauge the carpet cleaner's upkeep score, we thought-about the ease of emptying and rinsing the dirty water tank. With sizzling water extraction carpet cleansing(the perfect method for my part) you'll be able to't get away from the carpet being a little wet.
If you've got wall-to-wall carpet or a particularly giant and hulking rug you can't transport, name an expert steam cleaner for assist, as she is going to bring machines and professional-grade cleaning options straight to your home. I actually have made a printable for you you can see above with THREE different ways to scrub carpet naturally.
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Smiles tomorrow, I swear! xo
recovering!, originally uploaded by daniellehampton.
Your hoodie rules!ReplyDelete
My friend Sandy (whimsicalmee) pointed me to your blog--it's adorable! I just wanted to say hi and that I'll be following your blog! I love how positive you are--I need reminders to be positive sometimes!ReplyDelete
Cherie- thank you so much!
Stephanie! You are too sweet, I am so happy to meet you! <3333
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Account Manager
- Recruiter
- Neko London
- Location
- South West London
- Salary
- £25,000 - £35,000
- Posted
- 12 Apr 2018
- Closes
- 12 May 2018
- Ref
- Discipline
- Creative
- Specialism
- Account Management, Production
- Business Type
- Studio / Production
- Seniority
- Manager
- Contract Type
- Permanent
- Hours
- Full-Time
One of the most exciting London based agencies are looking for an Account Manager to join their team. Our client works with some of the greatest and largest retail and fashion companies and really focus on understanding their client's issues so they can offer solutions through services such as branding and strategy, photography, digital, studio and production, CGI and creative. Our client's approach to the way they work is extremely refreshing and has resulted in continued growth with their accounts. As well as an exciting breadth of clients, they also offer benefits such as free breakfast, team socials, cycle scheme, travel loan and more.
In this role, you will have the opportunity to work with a range of incredible clients and will ultimately be responsible for building and maintaining strong relationships with them. Day-to-day, your responsibilities will include taking briefs from your clients, understanding their business, their needs and discussing solutions to any existing problems then developing a creative strategy. You will need to schedule and cost each project then communicate the brief to Producers, staying close with them throughout production to ensure you are aware of any issues that may arise.
To be considered for this role you must have previous agency experience, a great knowledge of photography and experience working with clients and internal stakeholders. You must be a great communicator, pro-active, passionate about client services, always keeping your clients' updated and comfortable making the most of up-selling and cross-selling opportunities. It would be a great benefit for you to have a knowledge of digital and a strong creative background. Our client is looking for somebody with a can-do attitude, bubbly, happy and positive in personality as well as confident, strong and resilient in nature. Don't miss out on this amazing opportunity, please email your CV to email@example.com


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Temporary closure of Norwich Road
Norfolk County Council plans to make a temporary traffic order affecting Norwich Road, Reepham, from a point 30 metres north of its junction with Church Hill for a distance of 20 metres northwards as a BT engineer needs to work in an underground structure.
The road will be temporarily closed (except for access) for three days from Monday 22 January to Wednesday 24 January for the duration of the works.
The alternative route is via: Church Hill, Market Place, Station Road, New Road, The Moor and Norwich Road.
If necessary the restriction could run for a maximum period of 18 months from the date of the order.
Penalty: £1,000 maximum fine on conviction and/or endorsement for contravention.
- For further information, contact: Martin Dixon, Community and Environmental Services, Norfolk County Council. Tel: 0344 800 8020.


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KelaMaiMai Designs
I am creating and imagining all sorts of patterns all the time in my mind, especially what I need in my daily life or for my beloved ones.It is so rewarding to be able to create exactly what we need, mixing medias and customizing garments and accessories.
You may also find some handy or nice for you, therefore my designer "brand" is:
"KelaMaiMai Designs" the abbreviation and onomatopoeia of "Que la maille m'aille!", the french meaning of "May the stitch suite me !"
I am currently exploring what double-knitting technique offers and mixed medias (knitting, spinning, felting, crochet, weaving… in one project), but I am also eager to write patterns for socks, pullovers, baby stuff, toys, scarves, shawls and where ever my mind will bring my hands.
At the moment however, I am very busy and only keeping my notebooks full. I hope to be able to write the patterns in a near future.


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The Shattered Backboard version of the infamous Air Jordan 1 Retro High OG is a about to drop. The design is inspired by the broken backboard from Michael Jordan's devastating dunk during an exhibition match in Italy back in 1985 and the jersey His Airness was wearing during this game. The make-up boasts a premium leather upper dressed in a mixture of Black, Starfish, and Sail colorways, all seated atop a Sail midsole paired-up with a Starfish bottom.
Look for this Air Jordan 1 Retro High OG "Shattered Backboard" to be available Saturday June 27th at 9:00 CET on Nike.com and other select retailers including Basket4Ballers, EndClothing and SneakerSNStuff


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As of 2015, Berko unit heaters use electricity and require between 2,000 and 32,000 watts of power. The Berko unit heater model HUH724ST, for example, is able to generate up to 26,000 BTUs of heat per hour. Berko recommends this model for garage and shop use.
A larger Berko unit heater, such as the HUHAA1024 model, requires a larger power input. This particular model requires between 7,500 to 10,000 watts of power and can produce up to 34,120 BTUs per hour. A larger cabinet unit heater model, such as the CU900, can use between 2,000 to 32,000 watts depending on the size of the unit that is installed.


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Medical Oncology
An internist who specializes in the diagnosis and treatment of all types of cancer and other benign and malignant tumors. This specialist decides on and administers chemotherapy for malignancy, as well as consulting with surgeons and radiotherapists on other treatments for cancer.
Training Required:
Three years in internal medicine plus additional training and examination for certification in hematology or medical oncology.
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Dr. Paul E. Oberstein
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Right, so I've really committed to this whole online dating thing. Just for fun really. Just to get out and hopefully, have an interesting conversation. I never would have thought. Only took me 3 years to warm to the idea but there it is. Theres a lot of odd stuff out there and let me just immediately confess that I've only had 5 dates. Nevertheless despite my complete rookidom I have some completely unrequested tips for guys wanting to get some attention.
- if there's no photo you are immediately a wierdo stalker and serial killer. so don't bother posting without one.
- I know cycling has become some sort of wierd worldwide epidemic but please dudes do you have to post photos wth cycling helmets and lycra shorts on? FYI its just not a good look. i promise. yes. really.
- If you keep insisting on collecting me from my home on the first date the only people you are going to meet there will be the Popo because I'm going to have to assume you're up to no good.
- Do not post a profile picture posing naked to the waist and in your bed under any circumstances. Not any. Unless you have posted while in the throws of a devastating fever and are delirious we will have to assume that you are a sexual deviant. And you probably are.
- I thought this one would be for a girls only but apparently not. Dont post pictures from 10 years ago. even if you think you look exactly the same. You do not. I promise.
- It is not okay to make lude suggestive comments before we have even met. For example: Woman: "How will we recognise each other?" Man: " By your thong." We are not Ho's yo! Let me just add its not appropriate after we've met either. Can you at least let us feel you actually like our company and that its not all about punani for a little while? At least until you can gauge how frieky we might be and sometime gentlemen we'll surprise you…..but sometimes we will not so dont push it bro!
- This should not even need to be pointed out – but it sadly does, so! Do not – under any circumstances – not any at all – make fun of the person when you meet them. if you think it is funny and that you are the ultimate joker and such a fun guy because you poke fun at other people about something physical – or what they are wearing or any other thing – then you are a dickhead and you will die alone. Get a friekin life and a therapist because you've got some issues pal.
- Dont try and get me drunk because you think i'm going to put out if you do. its ridiculous and probably illegal. What you'll get instead is someone who can't speak coherantly, who starts talking about her ex and who may vomit.
- Have fun – look most of the time you're not gonna get any – sometimes you'll meet someone that you really have a spark with and then you will get some. If you've happened upon a nympho you may very well get more than you bargained for but guys we know its not all about sex, no? It's also about having an affinity with someone and sometimes a great conversation is the best aphrodisiac.
- Listen – really listen when the gal is chatting. Ask questions – keep eye contact.Be interested. If you do your score rate will go right up. If she's insufferable go home alone. Dont try and salvage the evening with a quick poke. come on guys – do I have to say this?
- LEAVE YOUR DARN CELLPHONE IN YOUR POCKET. DO NOT LOOK AT IT, CHECK IT, TAKE CALLS UNLESS YOUR HOUSE IS BURNING DOWN OR YOUR CAR IS BEING STOLEN (you'll recognise those emergency numbers) If you cannot spend a few hours without looking at your phone you should date it.
So there we are. Thats my unrequested take on online dating from a 40 something. Its going to be soo different for 20 and 30 somethings. I would LOVE to hear some of your rules. And guys I would particularly love to hear from you. I've got an idea to compile all of these and make it into something very funny and put it on youtube so please please any comments would be AMAZING!!


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Of Health Care and Compensation
Sorry about the long absence, kids. I know you missed me- I missed you, too. And I know you need an Atlas update. So here ya go:
Still in the shadows...
I've successfully manuevered an ally and friend into position as my direct boss by begging the uber-boss to hire her back. Unfortunately, sh*t still rolls downhill. Of course, now that I'm no longer the lowest person on the totem pole, I can send sh*t downward, too.
Plus, there's this whole army of interns that shows up in the summers, too. And while I try not to abuse them it's nice having even more people that I could theoretically order around.
But it's not about me today. Today it's about a second-tier agency (at least according to Wikipedia) known as Innovative Artists.
Scott Harris, Innovative's head honcho, recently decided that in order to cut costs, he was going to cut out healthcare for ALL of the company's assistants, even the "senior" ones about to graduate to agency status.
Check out Defamer if you want the full backstory.
But basically, as ole Scotty tells it, he had two cost-cutting options: 1) Go with a crappy insurance company or 2) Cut insurance for assistants and keep everyone else with a decent insurance company.
So I guess we shouldn't be surprised which option he went with. But in the schmuckiest move I've seen since the supposedly "keeping it real" homegirl Tyra Banks broke a writer's strike, Harris made the cut RETROACTIVE. That's right, the assistants were under the impression they had healthcare in June. Ha ha, suckers.
So then Harris does this song-and-dance about how he's really cutting healthcare because he wants to pay assistants more. Dude, not even Leslie Sloane Zelnick could sell that sh*t line.
So Innovative Artists assistants, I beseech you: fight back. Because even if you don't win, you're young and you'll bounce back. What's the worst that could happen? You could get fired from a crappy job with bad pay and no benefits? Hell, at least McDonald's gives you health care if you work full-time. And they pay overtime.
And if you do win, you'll get healthcare, money, and the eternal gratefulness of the eternally-downtrodden. (ie-other assistants)
And here's how to do it: you know how you're always working overtime and never really getting paid for it?
That's actually completely illegal.
So just send a friendly email to the California Department of Industrial Relations or give 'em a call. Despite the retro name, they will get all up in the grill of companies. Remember, we live in California where the government is full of liberal, secular, Communist pinko bureaucrats...you know they'd be good for something, right?
And Scott Harris, you are a complete asshat. Good luck trying to attract Ho'wood players now that everyone knows you have no money.
So in the interests of screwing over Scott Harris and the increasingly third-tier Innovative as much as possible, here are their top clients (in order of IMDB starpower) that are just ripe for the stealing:
Channing Tatum - Already gone, according to Variety, following agent Louise Ward to William Morris.
Please take me away to CAA.
Amanda Seyfried - gets a ton of work, very much up-and-coming, a rare young starlet with acting ability.
Tina Majorino - similar to Seyfried, but has that cute-geek cachet.
Robert Iler - Sopranos is done, but if he can keep out of trouble, he could have a solid career. Plus, he's very young, so he'll be a moneymaker for years.
Eric Dane - Dr. McSteamy has never been hotter...so what's he doing at a second-tier agency?
Ian Somerhalder - Career's in a bit of funk, but an agency jump could cure that, no?
Now, I was going to name more, but frankly, their client list is already pretty thin. So come on CAA, if you're going to pounce, do it now while they're rudderless and weak.
See what you've done to me, Scott Harris? You've gotten me so mad I'm rooting for CAA.
So either Hell has frozen over, or Scott Harris is the greediest dickwad SOB on the planet.
UPDATE: Success! Innovative Artists has restored the assistants' healthcare! See! Kvetching does work!
TECHNORATI TAGS: health care, scott harris, innovative artists, strike, CAA, Amanda Seyfried, Leslie Sloane Zelnik, assistants, Hollywood
Labels: assistants, compensation, health care, Hollywood, Innovative Artists, Scott Harris, strikes


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Big Bend Conservancy is governed by a Board of Directors that reside across Texas and in Washington DC. The Board decides the organization's priorities for funding, projects and partnerships in partnership with Park staff.
2017-2018 Board of Directors
Dennis Kearns - President, Austin
George Easterly - Treasurer, Houston
Matthew Bell - Vice President of Development, Houston
Gene Fisseler - Vice President of Membership, Houston
Brenda Steuer - Vice President of Communications, Houston
Joe Tooley - Secretary, Rockwall
Kris Fischer, Cottonwood Shores and Terlingua
Elizabeth Friedman, San Antonio
Jose Gaona, Midland
Pam Hall, San Antonio
Billy Hassell, Ft. Worth
Joan Hicks, Ft. Worth
Chris Holmes, Waco
Helen Johnson, Austin
Ann Kovich - Past President, Ft. Worth
Don Lewis, Waco
William McGovern, Waco
Paul Nugent, Houston
Patrick Reinhart, Austin
Truett Roberts, Ft. Worth
Ron Sommers, Marfa and Houston
In addition to the Board of Directors, the Conservancy employs two staff members. Please email or call staff if you have questions about your membership or would like to make a donation.
Courtney Lyons-Garcia
Executive Director
Arlene Griffis
Membership Coordinator


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Only 4 products can be compared at once. Adding this product will remove the product you added to the list first.
Do you want to continue?
Double protection. All around SnakeSkin and RaceGuard under the tread provides maximum security for off-road tyres. Ideal for use on E-MTB's.
Tyres with this certification feature the best technologies for use with E-Bikes. They meet and excel past the ECE-R75 certification, meaning they are valid for use throughout Europe.
|Sizing Guide
|ETRTO Number
|Dimension (26")
|26 x 1
|26 x 1.25
|26 x 1.5
|26 x 1.75
|26 x 1.9
|26 x 2.1
|26 x 2.125
|26 x 2.2
|26 x 2.4
|ETRTO Number
|Dimension (29")
|29 x 2.0
|29 x 2.2
|29 x 2.4
|This is a generic size guide and not all tyres will come in the sizes shown.
The delivery options available for shipping this product along with the contents of your basket to USA are:
We will happily refund any item purchased on Wiggle if returned to us within 365 days; excluding Wiggle gift vouchers, nutrition and customised products, except when faulty.
Please note: Bikes and other bulky items cannot be returned using our local returns service (where applicable). Please contact us and we can arrange to collect these from you using our discounted courier rates. There is a fee for all collections, except for faulty products.Returned goods must be unused and supplied with their original packaging, unless the goods are faulty. Wiggle will pay the return postage costs for any faulty items.


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For readers of Unbroken, out of the depths of the Depression comes an irresistible story about beating the odds and finding hope in the most desperate of times—the improbable, intimate account of how nine working-class boys from the American West showed the world at the 1936 Olympics in Berlin what true grit really meant.
It was an unlikely quest from the start. With a team composed of the sons of loggers, shipyard workers, and farmers, the University of Washington's eight-oar crew team was never expected to defeat the elite teams of the East Coast and Great Britain, yet they did, going on to shock the world by defeating the German team rowing for Adolf Hitler. The emotional heart of the tale lies with Joe Rantz, a teenager without family or prospects, who rows not only to regain his shattered self-regard but also to find a real place for himself in the world. Drawing on the boys' own journals and vivid memories of a once-in-a-lifetime shared dream, Brown has created an unforgettable portrait of an era, a celebration of a remarkable achievement, and a chronicle of one extraordinary young man's personal quest.
The Boys In the Boat a Remarkable True Story
The generation of men who went off to war after Pearl Harbor were mercilessly
bombed on that fateful morning in December, are now referred to as, in
no small part thanks to Journalist Tom Brokaw, The Greatest Generation. They,
and the loved ones they left behind to fight the war on the Homefront are given
this label because they, without question, saw a call to duty to defend the
However, in the 1930's, America was in the gripes of The Great Depression
while across the ocean in Germany, a thug named Adolf Hitler was slowly
gaining momentum.There is another story as well. The story of the nine men
from the University of Washington and their remarkable journey to the 1936
Olympics in Berlin. They came from all over the state of Washington and all
socioeconomic backgrounds. They had a common bond, rowing. A sport that
is usually reserved for the elite boarding schools of Eaton and Harrow and
universities such as Oxford and Cambridge and Ivy League Institutions.
Schools such as Stanford and Cal Berkely fell into this category and already
had strong traditions by the time nine young men from Washington made
people sit up and take notice. Within this amazing story of courage and perseverance,
the stories of the rowers themselves are intertwined.
While the nine young men, their coach, and their boat maker were
not well known, there are three names you will come across that will be recognizable.
Jesse Owens, Louis Zamperini and a man, a Brit, by the last name of
Laurie. His son would become a very well known actor many years later.
There are so many stories about the Second World War on the market to
read. This is a good thing because it ensures that The Greatest Generation will
live on through their stories, even after they gone.
The members of the University of Washington rowing team who went to Berlin in 1936 are all deceased now. Their contribution to the war effort was not through physical
fighting, although many of them did enlist after Pearl Harbor. Theirs was a victory
of the hearts and the minds of America. In the face of tyranny, they made
America believe.


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Good Karma at The Bud
- July 21, 2014
- Uncategorized
- 1 Comments
More than 300 people took part in mass yoga class at Budweiser Gardens in London, Ontario on Sunday, July 20, 2014. The fourth annual event billed "The Yoga Shack Gives Back 2014" was free but donations for the charity "Growing Chefs" were accepted. The event of was hosted by Lisa Shackleton, owner of Yoga Shack in Wortley Village.
Read the full article at http://virtual.lfpress.com/doc/londonfreepress/enterprisejune2014/2014062901/#12


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Extra Sugarfree Gum Classic Bubble15ea x 10 pack
Quick view
Long Lasting Flavor. 10 fifteen stick packages
35% fewer calories than sugared gum. Calorie content of this size piece has been reduced from 8 to 5 calories.
Accepted by the American Dental Association
©WM Wrigley Jr Co
This product can be shipped to a Walgreens store for FREE
This product has no shipping restrictions.
Shipping Weight (in lbs): 1.16
Product in inches (LxWxH): 3.3x 5.2x 2.55
Item Code: 236027
*Many of these answers are provided by manufacturers or other customers. Walgreens does not review, verify, or endorse those answers, which represent the sole opinions of those parties.


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1057PD - Final results from a Cancer Research UK first in man Phase I trial of IMA950 (a novel multi peptide vaccine) plus GM-CSF in patients with newly dia...
|28 September 2014
|Immunotherapy of cancer
| Immunotherapy
Central Nervous System Malignancies
|Sarah Halford
|Annals of Oncology (2014) 25 (suppl_4): iv361-iv372. 10.1093/annonc/mdu342
S. Halford1, R. Rampling2, A. James3, S. Peoples4, P. Mulholland5, O. Al-Salihi6, C. Twelves7, C. McBain8, S. Jefferies9, S. Kutscher10, N. Hilf10, L. McGuigan1, J. Peters1, K. Roberts1, O. Schoor10, J. Ritchie1, H. Singh-Jasuja10
To determine the safety and immunogenicity of IMA950, a novel multi-peptide glioblastoma (GBM) specific therapeutic vaccine that contains 11 HLA-binding tumour-associated peptides (TUMAPs), identified on human leukocyte antigen (HLA) surface receptors in primary human GBM tissue.
Patients (pts) were eligible for standard therapy and HLA-A*02 positive. Vaccination comprised 11 intradermal IMA950 plus GM-CSF injections over a 24 week period, beginning 7-14 days prior to initial chemoradiotherapy (CRT) in Cohort 1 or at least 7 days post CRT and 28 days prior to adjuvant temozolomide in Cohort 2. Safety was assessed according to NCI CTCAE Version 4.0 and immune responses determined by HLA-multimer analysis of vaccine-induced T-cell response in PBMCs. Secondary objectives included observation of progression-free survival (PFS), measurement of pre-treatment regulatory T-cell (Treg) levels and evaluation of the effect of steroids on T-cell responses.
Forty five pts were recruited and all were evaluable for safety. Related adverse events included minor injection site reactions (26 pts), rash (5 pts), pruritus (4 pts), fatigue (3 pts), neutropenia (2 pts) and single cases of allergic reaction, anaemia and anaphylaxis. Two pts experienced a dose limiting toxicity of G3 fatigue and G3 anaphylaxis. Of 40 evaluable patients 36 (90%) were TUMAP responders, and 20 (50%) were multi-TUMAP responders with no important differences between the cohorts. No clear effect of pre-treatment Treg levels on IMA950 immunogenicity was observed and no differences in TUMAP responses were noted between pts who were and were not receiving concomitant steroid treatment. PFS was 74% at 6 months and 31% at 9 months. Survival data continues to be collected, with a current median overall survival of 15 months and 11 patients reported to be alive as of 01-May-14.
IMA950 plus GM-CSF given alongside standard treatment for GBM was well tolerated with the primary immunogenicity success endpoint of observing multi-TUMAP responses in at least 30% of patients being exceeded. Further development of IMA950 is therefore encouraged.
S. Kutscher, N. Hilf and O. Schoor: is an employee of Immatics Biotechnologies; H. Singh-Jasuja: is a stock holder and employee of Immatics Biotechnologies. All other authors have declared no conflicts of interest.


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English: ACT or SAT Test Scores
Official ACT or SAT scores are required for:
- all new freshmen;
- all transfer and reentry students who have not satisfactorily completed at least one college-level course in English composition;
- transfer students who have completed fewer than 15 transferable credits at the time of application;
- special (non-degree) students who want to enroll in an English composition course;
- students wishing to be eligible for intercollegiate athletics.
ACT/SAT test scores are used to provide a basis for course level placement in English composition, and to provide benchmark data for assessing verbal and quantitative skills developed by freshmen and sophomores. The test score policy also complies with University of Wisconsin System Regents policy and may be used by the Admissions Office to support a student's admission to the University.
Mathematics: Wisconsin Mathematics Placement Test
The Wisconsin Mathematics Placement Test (WMPT) is required for:
- all new freshmen;
- all transfer and reentry students who have not satisfactorily completed a college-level mathematics course;
- all special students who want to enroll in a mathematics course.
WI Placement Tests are scheduled throughout the state from March through June. Students not able to take a regional test may take one of the residual tests scheduled on campus near the start of each term or during the semester. The test results determine the course level placement for mathematics courses. A $30.00 test fee will normally be added to each student's tuition bill in the fall semester.


text:
Tododesign offers 2 Products Category:
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By choosing the Paypal payment method the customer can pay directly through your Verified PayPal Accounts. We accept Paypal payment from Verified accounts and reserves the right to ship the goods to the address on the account verified by PayPal. Payments sent from unverified Paypal accounts will may be canceled.
If you life in other country please send a mail to info(@)arq4design.com with link of product and your country for calculate shipping price.
– 2 >>> "BUY IN OFFICIAL STORE" Products: You buy directly in the official store of the brand
Shipping:it depends on the brand and where you live, so CLICK to Buy in Official Store and ..enjoy!