text:
What I Wore - Shabby Apple Ed.
The sweet people from Shabby Apple were kind enough to send over a dress for a little review. My review? I am in LOVE! No Ellie did not pick the shoes for this dress, but my Mr. told me which looked best. We thought we would make it extra fun so I donned some red lipstick and we did a little shoot. Now Ellie thinks I should wear lipstick everyday, but alas that will not happen since I rarely even wear makeup. Isn't this dress just the sweetest? One of my sisters thought so too and when she tried it on I could tell she felt pretty so it now hangs in her closet. Everyone needs a dress that makes them feel extra special. So a dress that makes you feel pretty and special, now that's a winner. I can't wait to try their fitness line and this swimsuit is just too divine, oh and to order another dress, ha!
76 comments:
- Engracia said...
Wow, you look absolutely stunning Paula. The colour, stripes and style of dress really suits and I think Ellie is right about the lippie (I don't wear makeup either, but still wear lippie, really makes a difference I think).
Happy weekend.
- June 18, 2010 at 2:37 AM
- MCD said...
Love the vintage feel of this dress!
- June 18, 2010 at 3:12 AM
- :: Lavender's Green :: said...
I love that dress! It suits you so much.
x Jasmine
- June 18, 2010 at 3:57 AM
- Deb said...
I think you look just adorable! Its funny but when I looked at the image on the Shabby Apple site i wouldnt have looked twice at this dress, but when I see it on you it looks too cute! Now I want one. :-D
- June 18, 2010 at 4:05 AM
- Anna said...
Paula...that dress is SO SO you..you look just beautiful..and I love that shade of lippy on you too..yummy mummy you are.
Thanks so much for the heads up..I have two weddings coming up and I dont know what on earth Im wearing??? had a look at Shabby apples site...just divine gowns and so reasonable priced. thanks again x
- June 18, 2010 at 5:42 AM
you look lovely, it's a sweet dress and the sash just gives it such a twist, the colours look great on you and the lipstick sets it off wonderfully.
- June 18, 2010 at 5:59 AM
- A Perfect Gray said...
nice. from an artistic point, the second shot with the neck and hair wisps is amazing...
- June 18, 2010 at 6:23 AM
- Melissa said...
The dress is so beautiful-- glam and yet looks really comfy, too. Love, love the pleats in the skirt. You look so beautiful-- I agree with Ellie that a little lipstick every day goes a long way towards making you feel more beautiful! You should frame that second shot for your hubs-- my hubs would brag all over town if he had one so lovely of me!
- June 18, 2010 at 6:25 AM
- tracie @ {tsj} photography said...
WAY TOO cute!! and no fair your hubs is a photog! ;)
- June 18, 2010 at 6:47 AM
- Maria said...
so perfectly adorable on you, Paula....i think my favorite and that lipstick is amazing! beautiful!
- June 18, 2010 at 6:48 AM
- Courtney at Scattering Lupines said...
That dress is awesome! And you look like you were fit to model it! The lipstick is a perfect touch :)
- June 18, 2010 at 6:56 AM
- Design Esquire said...
That dress is gorgeous, and you are a wonderful sister! Have a great weekend!
- June 18, 2010 at 7:05 AM
- bluehydrangea said...
Paula, you look adorable!! love the dress!! I agree with Design Esquire, you are a great sister.
- June 18, 2010 at 7:06 AM
- Danielle (elleinadspir) said...
Thst dress is perfection. And I love that you shared the pretty feeling with your sis.
- June 18, 2010 at 7:08 AM
- pve design said...
My first visit here and you are ravishing in that dress Lady! I love the way a dress can immediately make one a Lady! Red lips do that too.
Can Shabby Apple send me that suit? I am in love.
I want to send my sisters something from there....
- June 18, 2010 at 7:09 AM
- Stacy of KSW said...
Paula - you look absolutely stunning - what a deal Shabby Apple got asking you to do the review :) They should put your pics up on their website, they're catalog worthy
- June 18, 2010 at 7:24 AM
- Stacy of KSW said...
Ok, just went to the site to see the dress and nothing against the doll they have modeling it but you look 100x better in it :) They really should update the listing with your pics or better yet pay you to model their line
- June 18, 2010 at 7:26 AM
- Joslyn said...
this dress is adorable and you look COMPLETELY stunning...yes, it's a shabby apple week ;-)
have a great weekend!
- June 18, 2010 at 7:48 AM
- Elizabeth said...
This looks like it could be in their magazine. Thanks for posting this. I came across their website over a year ago, but didn't order anything and have been trying to think of the name for almost a month. Now I know! This looks great on you!
- June 18, 2010 at 7:57 AM
- Virginia @ Where You Hang Your Hat said...
Love it ALL! The dress is a dream and so are the photo and your gorgeous red lips!
- June 18, 2010 at 8:12 AM
- Pink Wallpaper said...
You look so pretty Paula!! Looks perfect on you so you might have to borrow it from your sis :)
- June 18, 2010 at 8:16 AM
- Heather said...
This is just the cutest, and you look terrific! It looks so Kate Spade. I saw it was called "Sheep Meadow", so now you and the kids have to come to NYC and stroll through Sheep Meadow in Central Park for another photo shoot!
- June 18, 2010 at 8:23 AM
- Staley Mc said...
Love that dress- so adorable! Hope you have a great weekend!
- June 18, 2010 at 8:36 AM
- sarah, flourish design + style said...
Love, love ,love it! What a great dress, and the whole look is perfection. How lovely to give it to your sis...I'm going to have to check out Shabby Apple, see if there's a little something for me! xx
- June 18, 2010 at 8:40 AM
- Estelle said...
Yes, you could pull of red lips everyday. You look fantastic! And I love that dress. All the colors feel so fresh.
- June 18, 2010 at 9:00 AM
- Stephanie said...
Paula, you look absolutely beautiful. I love the dress and your red lipstick! Checking out Shabby Apple now :)
- June 18, 2010 at 9:15 AM
- Blueprint Bliss said...
Love it and you look so great. I think I might order myself a dress or two to celebrate no longer being in maternity clothes!
- June 18, 2010 at 9:21 AM
- Full House said...
So pretty and fun to see you with that red lipstick...just stunning.
Have a great weekend!
- June 18, 2010 at 9:26 AM
- Jennie Bee said...
Great Dress!!! the Red Lipstick is perfect for it!
- June 18, 2010 at 9:33 AM
- coolkids said...
Paula you look absolutely perfect! I think you will help shabby apple sales today!:)
- June 18, 2010 at 9:41 AM
- Alexandra Rae said...
You look beautiful. And since those are my company colors (well, were) I am buying that for moi!
- June 18, 2010 at 10:21 AM
- joAnna said...
great dress - love the lipstick it always goes a long way!
Stop by and help with a front entrance decision - can use all the help I can get.
- June 18, 2010 at 10:22 AM
- Gramercy Home said...
Great dress. Great Lipstick. Great photos. I'm now going to try to work on my style in one image. Mine changes daily too!
- June 18, 2010 at 10:31 AM
- Jennifer said...
darling!! love the red lips! you could rock them without a face full of makeup!
- June 18, 2010 at 10:36 AM
- eden lang said...
I love Shabby Apple! and this dress is so cute. and you even got some fun pictures too! very nice.
- June 18, 2010 at 12:41 PM
- Deepali Kalia Interior Design Blog Filling Spaces said...
It looks so pretty,you look beautiful:)
- June 18, 2010 at 1:07 PM
- Jessica said...
absolutely gorgeous! love love love this dress!
- June 18, 2010 at 1:29 PM
- Julie Holloway said...
wow! the dress is great...but you look so pretty in it! That first picture. If that was me I would frame it for myself :) They need to do a give away on your blog...I want one for me :)
- June 18, 2010 at 1:34 PM
- Char said...
gorgeous dress! i agree - it's perfect for you.
- June 18, 2010 at 2:20 PM
- la la Lovely said...
Umm hello model... you look super gorge! I just read about Shabby Apple yesterday. Dear Shabby Apple, will you send me a dress to review?
Ok, I need your J Crew help... .stop by because I know you can help!
xoxox happy weekend to you and your sweet fam!
- June 18, 2010 at 2:31 PM
- Wahzat Gayle said...
You look fabulous!!!
So do get to keep it and on a hot date with your hubbie?
It really looks great on you!
have a great weekend P
- June 18, 2010 at 3:32 PM
- Amy said...
You look darling! My figure is not horizontal-stripe friendly but I love that on you!
- June 18, 2010 at 3:40 PM
- Hanako66 said...
you look absolutely beautiful!
- June 18, 2010 at 3:48 PM
- Mackenzie {Design Darling} said...
oh my gosh, you MUST reorder the same dress! you look fantastic and the red lipstick is just the icing on the cake. gorgeous, gorgeous, gorgeous!
- June 18, 2010 at 5:01 PM
- and flowers pick themselves said...
i love everything about this dress! the color + cut + stripes...gorgeous!
xo Alison
- June 18, 2010 at 5:59 PM
- kasey said...
- June 18, 2010 at 7:07 PM
- simply seleta said...
Hello model. Gorgeous shots!!! Love love love the dress. So preppy yet girly. Has a Kate Spade feel. I'm heading over to look at it. : )
- June 18, 2010 at 11:50 PM
- Melissa@Vidastyle said...
Gorgeous dress, you look beautiful. Love the photos!
- June 19, 2010 at 6:03 AM
- ms. less is always more said...
It looks amazing on you... and I love the lipstick! Hot mama!
- June 19, 2010 at 7:36 AM
- knk said...
beautiful stripes you looks amazing looks like princess
- June 19, 2010 at 7:57 AM
- rikshaw design said...
you need to be a model for them..such a beautiful girl you are!!
- June 19, 2010 at 11:12 AM
- Stephanie Sabbe said...
you are So pretty! looks like a JCrew ad!
- June 19, 2010 at 3:17 PM
Love the dress! And you look great...as ususal (:
- June 19, 2010 at 9:14 PM
- orange sugar home said...
that dress is GORGEOUS on you. the colors against your glowing skin are perfect!! wow. I love green and blues together. the right dress is a must....I need to start searching.
- June 19, 2010 at 10:33 PM
- Lavender and Lilies said...
How fun! I love the dress.
- June 19, 2010 at 10:45 PM
- Cassie said...
I adore the blue/green combo and it looks stunning on you Paula! I love the look of your shoes too from the little glimpse I get.
I am in love in fact with your shoe collection so far!
- June 20, 2010 at 5:01 AM
- pam@pixelimpress said...
super cute! great colors and it has pockets! pam
- June 20, 2010 at 3:03 PM
- Kelle Dame said...
Watch out!! You are dashing my dear! The lipstick is perfect. I love shabby apple and one day when I am a brick and mortar enterprise I will wear their dresses everyday!
- June 20, 2010 at 3:12 PM
- Tanya (a Taste of T) said...
You look amazing! Great dress.
- June 20, 2010 at 3:22 PM
- Tanya (a Taste of T) said...
You look amazing! Great dress.
- June 20, 2010 at 3:22 PM
- Gracie said...
You look so sweet and glamourous. The lipstick is a nice touch. the dress is just beautiful! I wish I could wear more dresses like that one. x
- June 20, 2010 at 9:13 PM
- Splendid Willow said...
Paula, smart move by Shabby Apple! They should send you something new every week! They found the most perfect model! (But I can't believe you let your sister snag the dress! It is adorable!)
ox, Mon
- June 21, 2010 at 1:14 AM
- Dayka (Life +Style) said...
this dress looks great on you! i love the fit.
- June 21, 2010 at 9:01 AM
You look so, so beautiful!
- June 21, 2010 at 5:10 PM
- Susie (So Blessed) said...
How pretty you look, Paula.
Love the dress on you. You
look great!
- June 21, 2010 at 6:02 PM
- Haven and Home said...
The dress is very cute but I must say I am LOVING the red lips!!!
- June 22, 2010 at 6:55 PM
- Pink to Green said...
I love all your what I wore posts but this one is a stand-out... you look absolutely stunning. The colors, the cut of the dress and your styling are so timeless and beautiful!
- June 23, 2010 at 9:13 PM
- Sarah said...
Okay, you are the best sis ever because I ADORE this dress. It screams my style.. I am heading to the shop now to check out more adorable stuff. You are one lucky lady.
- June 25, 2010 at 2:26 AM
- Vana said...
thanks for introducing me to them:) I think i'll be hooked for a long time:) You look amazing on it. It's like it was made for you, paula~
- June 25, 2010 at 8:11 AM
- LindsB said...
OMG, I almost picked this dress for my giveaway one, I LOVE it!!
Check out my blog for a different Shabby Apple giveaway dress
- June 25, 2010 at 2:42 PM
- JMay said...
omg, I adore that dress. You look Regina Spektor CUTE!!!
- June 28, 2010 at 2:38 AM
- Emily Curfew said...
that dress looks perfect on you!!
- July 2, 2010 at 6:45 PM
- Anna said...
I am so happy I tumbled into your blogland! I'm working my way through your posts and loving it.
And that dress? Brilliant. I love it and it looks just fantastic on you.
- July 29, 2010 at 6:44 PM
- Colleen said...
Oh wow, I love this dress. Green and blue combinations are my favorite. And you look absolutely stunning.
- August 25, 2010 at 11:10 AM
- Melissa said...
you are so gorgeous! love your style! what color lipstick is that? beautiful!
- October 16, 2010 at 7:55 PM
- paula said...
the lip color is penelope's red 320 by l'oreal colour riche :)
- October 23, 2010 at 12:12 PM


text:
Product benefits
Compatibility2 strap buckles, either 20 mm or 25 mm wide.
Ease of useEasy attachment to webbing, even the male side with a slot for insertion.
Product feature
For replacing a buckleThere are many kinds of buckles of this type, you will probably also need to replace 2 parts of the damaged buckle (male and female). We chose to list a buckle that enables replacement without sewing thanks to the slot for the strap to be fed through if there is no free end for it to pass through.
Product testing
CompositionBuckles : 100.0% Polyamide (PA)
Product catchlineFor easily replacing buckles (without sewing) for 20 mm or 25 mm straps or creating a fastener. Buckles sold in packs of 2.

subset: commoncrawl


text:
- By Peter Guy
Sugababe Heidi Range enjoys tough gym session in Liverpool ONE
Strictly Come Dancing star enjoys rigorous workout
Having stepped up her fitness with non-stop energetic routines on last year's Strictly Come Dancing (Dancing On Ice - JEF), Heidi Range is already in pretty top-notch shape.
But you don't get a fabulous figure and keep it without some effort, so while she was back in Liverpool visiting friends and family the Sugababe took the opportunity to join her sister Hayley for a tough gym session.
The girls were put through their paces by trainer Darren Johnson, who works out of the Gym Group at Liverpool One.
Insider hears Darren gave Heidi – who recently celebrated her 30th birthday – and Hayley a rigorous but fun routine to follow, leaving them with aching legs.
So much so, in fact, that the singer Tweeted the next day: "@DarrenJohnson69 Thank you for the full on workout. Ouch though, me and @Hayleyrange are feeling it today!"


text:
When the Redmi note 4 in blue colour available on mi.com/in flipkart. And when the another sale start on which date
Sorry only them will know when it will be available. Visit Redmi Note 4 page in Flipkart again and enter your email so you get a notification when it is available.


text:
It's alarming that information overload is getting worse despite some amazing technology. The more information we have access to, the more we wish we had a trustworthy way of finding it when needed: A way that thinks as we do.
This is the story of how one person took a visual way of organizing information and added a new ingredient - the magic sauce that makes this really different. I'll get to the sauce later.
Indexing software There are many: Google Desktop; Windows Desktop Search; X1; Copernic; Cindex; Macrex; SKY Index . . . many more. These programs can be useful. They undeniably help find things sometimes but for me, indexing software offers only a limited solution. Why?
First: I can't always identify the right phrase. I was looking for something I copied from the web about stress in children. I looked for 'reduce stress', 'stress reduction', 'cope with stress'. The specific item I wanted, when I found it by hunting, turned out to mention 'alleviate stress'. I remember concepts, not specific words.
Second: I'm sure you know - too many results! When an index search gives any hits at all, it gives too many hits for me to want to search through. In the case I just mentioned, searching for the word 'stress' alone gave far too many results (and I must stress this point!)
Third: Drain on performance. Having indexing software running can slow a machine down. When moving files around or working on files temporarily, it will still index them. I know it's a temporary move, but the indexer doesn't. And if you do a daily backup, the indexes can add a lot to the load.
And Fourth: Whether I have indexing software or not, I have to impose some order on important material anyway - I just don't feel safe relying on indexing alone.
Visual representation The core of this post is that a visual approach is the best way I've found yet. I'll give you an illustration of this (even the word "illustration" says a lot) - a real story of how presenting things visually can often score strongly, the visual 'roadmap'
I worked with a client to pull together a visualization of all its many computer applications spread around the Asia Pacific region to show how they were linked, and what depended on what. It was a large diagram with a database holding the essential information in the background. It was intended as a position statement only, to support future planning with the database being key information, and the diagram as a quick overview. but it turned out that the visual element kept the project alive long after the original intended few months.
Here's what I delivered to the client - with a database behind the diagram:
The client took it over and two years later it had grown to this:
Ten years later, on another project for the same client, I found it was still being maintained and used.
Then it came in handy for a new project with a global scope. So this visual representation with its underlying database, originally conceived as temporary, was sticky enough to last for at least 11 years in Asia Pacific. Recently it has become a permanent way of tracking the company's computer applications in Europe. The database / visuals combination taught me something, and that is a key point for this post, but more about that later.
So what's the best visual approach for information management on computers?
- Many use the file system itself -- folders or directories, nesting one inside another to build a hierarchy - this is just a little visual, but not very
- Some use a simpler lists method - not visual at all
- Many are disorganized and would have you believe they're proud of it - not visual
- Word indexing with software is a solution for some - not visual
- Some have an enviably good memory and just know where they put things - still not visual and no good for me
- But increasingly, people use some form of visual layout with files attached
I've used mind mapping (left - a mind map from ThinkBuzan) and concept mapping (right - a conceptmap) for more than 30 years for idea generation, facilitating meetings, planning, and organizing projects. They are personal, individualistic and flexible.
As you're at Visualmapper's blog you probably know about these, but in case not, here are two links with a quick explanation: concept maps and mind maps.
Most software for making these lets you attach files and URLs to nodes, but managing realistic volumes of information this way would be difficult.
For serious work, the mindmaps became seriously big. At a readable size, the example on the right (used to plan and control a project) needs to be read in sections on a large screen, and though it was useful in a project, it wasn't ideal. The rigid tree structure was also a problem. Any item could be a child of only one node so I couldn't link a node to two parents. Multiple parents are a hierarchy and are often needed in managing information. People used to make photocopies of typed documents, for example, one for the client file perhaps and one for the project file.
Then came TheBrain (yes, it was alloneword). I learned about this in early 1998, while it was still in v.1 Beta, and gave Natrificial some feedback. Some of the ideas made it into the product, though I don't imagine I was the only person suggesting them.
I used this for a year actively, another year less often, and another year just occasionally when I had specific things to look up. I had a lot of personal information in there, some client projects and some business planning ideas. At first I was very enthusiastic, but the enthusiasm waned as I came to see the limitations.
Advantages TheBrain had a mind-map way of thinking without the tree limitations of mind maps. You could centre on any node and wander around the map so the size limitation was less significant. And any item could be a child of many nodes. This was one thing I really wanted. If I have a piece on Hong Kong businesses obligations under the Personal Data (Privacy) Ordinance, it can appear under 'Hong Kong law', 'privacy', 'corporate governance' and 'IT practice'. Then, searching down any one of four branches will bring you to the same item.
Limitations For years (long after I abandoned it) only one item could be saved against a node, so a six-page web article needed six nodes. An unnecessary restriction.
For large, complex projects, visibility is highly limited, even with a 24-inch screen at 1920x1200.
There was no "sense of place", little to help me recognize the surroundings and home in more quickly on what I wanted. This has turned out to be really important now I use software that does offer this.
Minimize abstraction Abstraction is the enemy of quick comprehension. We must make things concrete to remember them. At this point my company signed an agreement with 3D-Scape Limited to develop an information organizer, so the thinking I'd been doing for years, on and off, crystallized. We needed a concrete way of presenting information.
Use visual methods The visual approach has great potential, but using 2D mapping had the problems touched on already, like impractical map size for significant (but not huge) projects and the poor visibility that results. This was where the magic sauce - 3D - came into the information management picture.
The design rules were these:
1. Present information visually, and in 3D to open up the space on the screen, with zooming and flying;
2. Use a mindmapping or concept mapping way of thinking;
3. Allow multiple parents for any node (we call nodes Topics);
4. Allow multiple attachments per node (we call attachments Occurrences);
5. Allow importing from nested folders, outline-formatted text and popular mapping software and reflect the organization of the folders and maps in the 3D landscape produced;
6. Files stored in it should be accessible in the normal way, as well as through the visual information organizer;
7. Behind the visual front end there should be a robust and fast database.
We set aside a day a week for ideas, experiment and discussion and had daily design discussion meetings. We had two artists coming up with multiple visual concepts. And on more than one occasion we had the unusual task, maybe unique for software designers, of working in clay, photographing the results, adjusting, making more models. Very concrete!
What we found In a concrete 3D space, you're not feeling around in your head for where you stored something. You can find what you're looking for more quickly. You feel much more confident that what you need can be found. You can show others that you're better organized.
3D mindmapping takes shape Taking that 2D example we gave earlier into 3D, we arrived at this. (The colored lines showing relationships between cones are optional.)
This project was actually done with a 2D mind map because it was pre-Topicscape but it shows how the nightmare of that 2D mindmap that we looked at before (the thumbnail on the right) can be tamed by moving it into 3D.
The topic cone "Findings" above is the focus of this view at present. We refer to it as the Current Topic. Any topic can be chosen to show as the current topic with its child topics in front and its parent topic(s) behind. Small cones in front of larger ones always represent the larger one's children. The parent of Findings is EPD REPORT, which is also the parent of Findings' siblings in three columns on the left.
Topic cones contain files, notes, web shortcuts and allow for the user's additional comments and descriptions against each topic and file. They can be colored and tagged, at will. This is the view inside a topic cone:
If you want more you can click the image on the right for an explanation of the Topicscape structure. The multi-parent capability in this is achieved with topic cloning.
Topics are nodes and Occurrences are often files containing information about the Topic in which they appear, but may also be fileless if you decide just to add a textual note to a Topic. Topics are linked by Associations (like relationships connecting ideas), and Associations may have Association Types, a descriptive phrase that defines how the topics are associated. In the image on the left, the Association Type is " is the capital of ". So you can capture knowledge as well as organize information, concept-map-style.
What does an info management software need to do?
Help you find information, help you place it That's what it's all about.
Indexing: Of course, Topicscape has word and phrase search - not my preferred approach, but it's a basic need. This works with information the user has added, as well as names, file types and dates. And there's a simple file content search or it can hook Topicscape's search directly to Google Desktop Search and Windows Desktop. Concept search: In Topicscape you will organize the material according to your own hierarchy of concepts. Then when you want to search and cannot remember the words, you can start as high up as you need to, and drill down according to the concepts you have established. Multiple parents increase the likelihood of finding an item in this type of search. Flags, tags and colors: You can add a flag to topics for quick, visual recognition; color files according to your own scheme, again for quickly spotting what you want; mark occurrences 'finished with' - this pushes them down the list, turns them grey and suppresses them from searches unless specially requested; make 'favorite' topics and occurrences - they will then appear in the Favorites menu.
Context: When organizing information, it's not just about files, but the context around the files to be referred to later by you directly or used in searches. You can add a description, note of author, and the source. Web shortcuts will fill in the source automatically.
Special help: It's useful for an information organizer to have a few tricks up its sleeve. Tricks like allowing a large document to be sliced up 'virtually' and organized visually, and edited in that form while retaining the integrity of the original. It does this by combining automatic wrappers and paste special. Tricks like a way of queuing web-page archiving to allow you to carry on surfing as interesting material is saved locally for later study. Turns out that this is red-hot for Web research. And tricks like a lightweight helper app that gives special help, even when Topicscape is not running.
Importing: One of the settled early principles was to allow importing and matching the implied organization of information in the 3D landscape produced. This applied to nested folders, outline-formatted text and some mapping software like FreeMind and MindManager. To give one example, here's the same material in folders and in a 3D landscape:
In folders, only the contents of one top-level folder can be seen, whereas in 3D all can be seen, examined closely, or flown around, giving an entirely different perspective (literally). A single mouse click while the Shift key is held down allows for an instant zoom in to the area around any topic (cone) and instant return, if needed.
Exporting: There are many forms of export as well. With FreeMind, even a round-trip is supported.
Previewing files: You can save any type of file in Topicscape, see it and open from there, but many types of file can be previewed in thumbnail, medium or large form without the need to open the file.
Here are just a few uses:
- Organizing reference material;
- Organizing and saving material on the fly as you research;
- Managing all the material for a project;
- Managing To Do lists and activities
Just think about your needs to organize files on your computer, capture web pages to study and control your notes. This brings a new dimension to those activities, which is both satisfying and effective.
For more information on this 3D information manager to judge for yourself, you may go here: http://www.topicscape.com/
This account by Roy Grubb of G&A Management Consultants Limited


text:
Today's Friday Five comes from Deb:
"I am fortunate to have some great encouragers in my life. The ones who know me the best are great at knowing when to challenge me, and when to just chill and let me figure it out myself. SO… think about the encouragers and challenges in YOUR life and tell us…"
1. After achieving a goal, do you set the bar higher, or rest on your laurels?
I usually set the bar higher. But I've got nothing against taking a break.
2, Which is better: a kick in the pants or a hug and a cuppa?
Oh, definitely the hug. I am not particularly responsive to criticism. I mean, I make mid-course corrections all the time in response to feedback, but you can make it a lot easier on both of it if you have something positive to say.
3. What's your baseline motivation? Fear? Competition? Not getting caught? ;)
I am pretty damn competitive. But that driving force has little place in my life these days.
4. When you're facing a big challenge, do you need to talk it out, or puzzle it out yourself?
I need to talk it out, at length and with anyone who might have something to contribute.
5. Who is in your corner – always? Who helps you achieve more than you imagined you could? (You don't have to give names)
I have a couple of mentors and colleagues who are always hugely supportive. And my kids ~ they're amazing. My daughter at 28 is insightful, compassionate, and articulate ~ often my go-to person whether I'm moving forward or completely stuck.
I don't have a bonus piece of art of music. Just the number . . .


text:
Drop by Mum's Lounge
1. Tell us a bit about yourself.
My name is Emma Marks and first and foremost I am a wife and a mother to 5 gorgeous children. They all keep me very busy and there is never a dull moment around out house.
2. How did Mum's Lounge come about?
Mum's Lounge came about when I felt like I was spending all my time 'googling' products and services I needed in my day to day life as a mother. I thought it would be great if there was a site that bought it all together and became a place Mum's felt like they wanted to retreat to in their down time.
3. What can people expect when they go onto Mum's Lounge?
When you come to the Lounge you can expect a lot of fun and laughs with our forum and blogging and a massive array of online shops in all areas important to mums including women's boutiques, children's boutiques, health & fitness, beauty & pampering, help entertaining, things to do with the kids, nannies & babysitters....to name just a few
4. What are some of your favourite blogs?
First and foremost I love our blogger Jolene Humphry, she is hilarious and every week she writes a new introduction for our weekly newsletter with one of her hilarious antics!
5. What was your latest online purchase?
My first niece just arrived so I have been spending a lot of time (and money) in baby boutiques shopping up big for her!
Register to become a part of their growing community or get connected via Facebook. Emma and other Mum's Lounge fans are waiting to chit chat away!
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Justin Bieber reportedly turned down $5 million to perform at a Republican National Convention event.
The 22-year-old singer was offered the huge amount for a 45-minute performance last week at a venue near Quicken Loans Arena in Cleveland where the RNC was held and although he was told that his performance would not be seen as an endorsement, Justin refused the offer, TMZ reports.
Canadian singer Justin and his team were reportedly told by the promoter that LeBron James was planning to take part in another event for the party, also without endorsing them, but LeBron denied having anything to do with them when contacted by Justin's representatives.
And the basketball star encouraged Justin to turn down the offer.
Justin's manager Scooter Braun, a staunch Democrat and supporter of Hillary Clinton, reportedly "told Justin it was up to him if he wanted to do the show, but he said he couldn't continue to represent the singer if he did, out of principle".
Meanwhile, Justin will be soaked with 800 gallons of perfectly purified water when he headlines V Festival 2016.
The 'Never Say Never' hitmaker will take to the stage on Saturday August 20 at the music extravaganza's Chelmsford venue, Hylands Park, in south east England and then travel to Weston Park, Staffordshire, West Midlands, for his headline set on Sunday August 21.
Justin's set is said to be the most challenging production the festival has ever seen in its 21-year history.
He has requested the water to be 40 degrees when it is fired at him on stage.


text: Though it's already cornered the market on videos of kids hilariously crying about things they don't understand and people freaking out on salvia, YouTube apparently wants more—specifically the respect that comes with being a serious competitor in the video-on-demand market. The Google-owned company has just signed new deals with studios like Universal, Warner Bros., and Sony to begin offering rentals of new films the same day they hit other, more established services like Amazon and iTunes. Ideally, the move would stimulate sales of their Google TV, which exists, as well as fight YouTube's image as a place primarily to watch all the dumb stuff we named up top, plus AutoTuned remixes of local crime reports. Of course, not simply combining the two seems to be ignoring what could be their selling point: using the already-established YouTube community to create a living, breathing dialogue on the cinema and how it's full of FAIL and is totally gay.


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Our environmental policy
This site, dedicated to ecotourism, is part of a regional tourist policy which aims to "make Provence-Alpes-Côte d'Azur a model for sustainable tourism" It has the triple aim of showing the natural wealth of the region, to help net surfers to identify tourism professionals in the region and to encourage them to adopt reasonable behaviour as tourists.
What is ecotourism ?
The International Society of Ecotourism (TIES), defines ecotourism as "a form of responsible travel in natural areas which contributes to the protection of the environment and to the well-being of local populations". Ecotourism has two main functions : the discovery of nature, through observation, interpretation, education and the study of natural environments, and encouraging respect for the environment, through limiting the ecological footprint, educating people about the environment, contributing to the well-being of local populations and supporting programmes for the conservation of biodiversity.
Ecotourism in Provence-Alpes-Côte d'Azur
The image of the region is strongly linked to sun, sea and sand. However, Provence-Alpes-Côte d'Azur has many other assets to offer and is proving to be an attractive destination to all those wishing to discover its outstanding natural heritage and to stay in areas within which respect for the environment is a priority.
The website ecotourismepaca.fr is a mine of information which will help you to prepare your ecotourist stay in Provence-Alpes-Côte d'Azur. On this site you will find accommodation with ecolabels, places to eat offering local produce, information on using environmentally friendly transport when travelling, suggestions for trips prepared by responsible operators, a presentation of the main natural areas in the region, and even initiatives to follow in order to take action to protect the environment.
Who are we ?
The Comité Régional du Tourisme Provence-Alpes-Côte d'Azur (CRT PACA), created by the Conseil Régional in 1987, has, as its principle aim, to promote the region to French and foreign tourists but also to national and international press, travel agencies and tour operators.


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Non-slip surface can be added to your bathtub refinish for an extra $35.
Adding a non-slip surface to your existing tub can help reduce your chances of injury resulting from a fall. Help protect your family and guests, and give them a safer bathing experience.
This material is virtually invisible to the eye, and will not detract from the glossy, bright and shiny finish of your new bathtub or shower.
Perfect for hotel bathtub refinishing as well.
We also offer specially designed non-skid bath mats.
These bath mats are made from textured rubber, and provide maximum nonslip safety without the need for suction cups, which may harm your refinishing tub. Available in white or clear, they are made with premium rubber, which is very durable and even safe for your washing machine.
For more information, please call One Day Bathtub Refinishing at (408) 940-1025


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Experience the immense forests and vast plains of ArkWorld's ARKA project, occupied by beasts from across time. Use a vast array of tools to build anything from a simple tree-house to massive traps for a herd of migrating Mammoths.
No files were found matching the criteria specified. We suggest you try the file list with no filter applied, to browse all available. Join now to share your own content, we welcome creators and consumers alike and look forward to your comments.


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Your Holiday Floral Dreams Have Just Been Answered
Whenever I'm hosting a party, I always buy a bunch of flowers from the Flower Mart or Trader Joe's with grand plans of making stunning floral arrangements. However, what with the cooking, table setting, cocktail making, and last-minute sprinting that a hostess does before an event, I end up running out of time, simply unwrapping the plastic, and throwing the flowers into the nearest vase with water. During the holidays, there's even less time for crafting pretty flowers, so when I heard about Flower Muse's new Holiday Host package, I couldn't help but feel as if my seasonal floral dilemmas prayers had been answered.
The three-shipment subscription delivers a beautiful flower arrangement to your front door on three different dates during the holidays. The first date is selected by the customer—you can choose the Wednesday before Thanksgiving or the day before your holiday open house in early December. The second arrangement arrives on Tuesday, December 22, and the third and final arrangement is delivered a week later, on Tuesday, December 29. Thus, if you're doing any hostessing over the holidays, you won't have to worry about flowers at all. The arrangements are customizable: Select from a variety of blooms, including roses, tulips, hydrangeas, and lilies.
To ensure that your flowers last for several days, trim the stems on the diagonal and place them in a chic and festive vase with plenty of fresh water.
Do you plan on having flowers delivered during the holidays?


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How do we 'practise' being happy in daily life?How do we 'translate' joy to practise in everyday life?
How do we 'make' ourselves happy, everday?
1) Make a list
No, not a shopping list, wish list or ' to do' list, but a 'Count your blessings' list!
One of the simplest and most effective ways is to make a list of all the wonderful things that have happened to you or are happening to you everyday.
These can be the smallest of things – for example,
someone said a kind word or complimented you;
something funny to laugh over;
spending time with friends,
being free from sickness and pain, etc.
At the end of the day, just run through the list!
You will be amazed at the things in your life that you can be thankful for
2) See the good
It is also important to cultivate a habit of seeing the good in things, even when things do not go our way.
Many events in our lives can be interpreted in both positive or negative ways.
It all boils down to how we choose to view things.
3) Beware of negativity
Each day, try to develop an awareness of your thoughts.
Once you catch yourself starting to worry, make an attempt to think more positively.
It's hard at first, but with practise it will become second nature.
4) Make a committed choice each day!
We all have a choice today and everyday.
Do you choose to be happy and thankful …
for the things that you have,
for the people in your lives,
for the simple pleasures that you enjoy,
for the air that you breathe
for the breeze and the sunshine
for the rain and refreshing waters
Or do you choose to be ungrateful and grumpy … even for the littlest things that go wrong.
Being happy does not mean that everything is perfect. It means that you have decided to look beyond the imperfections. The glass is both half empty and half full, it depends on how you choose to see it!
Make a commitment to being happy – it is the most important work of your life!


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Our Committment
When you turn to the Law Office of Jessica MacRae Sousa, P.C. for legal help, you can depend on our lawyers' expertise, our strong support staff, our large network of resources,and our knowledge of Massachusetts case law. When necessary, will allign ourselves with experts and industry professionals.
While we employ the traditional methods of handling a case, we also look creatively at alternate options. Our overall goal is to get the best results possible for you. To that end, we explore every avenue necessary to reach that objective. Whether we are able to obtain a fair settlement through negotiations or present your case to a jury, our attorneys will take all of the steps necessary to do what is right for you and ensure you receive the maximum recovery of damages to which you are entitled by law.
Our law firm has built a reputation on more than a decade of deep commitment to personal service, steadfast protection of our clients' legal rights and dedication to obtaining the maximum recovery of damages for each of our clients. Well-known for our trial work and our track record of verdicts and settlements, our attorneys have gained recognition from both our peers and our clients.
If you have questions about our legal services or would like to arrange an appointment with a dedicated attorney, we invite you to call 978-777-7272. We have attorneys available to speak with you. When you need legal help, we are always here for you.


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All Films.All Above Board.NOW INCLUDES TV SHOWS & TV LISTINGS
Simon Birch (Ian Michael Smith) is an anonymous kid in a small town, determined to prove that he's destined for heroism and glory. Despite this, he seems to find himself constantly in trouble. His best friend Joe (Joseph Mazzello) has been raised by his single mother (Ashley Judd), and is trying to discover the identity of his father, whom he has never met. Together, the two youngsters share their good times and their problems, forming an unbreakable bond. Features a cameo by Jim Carrey.


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Giving your Children their very own Nativity Scene is a great way to introduce them to the miracle of Christmas. This Nativity Scene is produced by Playmobil. It can be found in most local departments stores. (We bought this one at Target.)
Friday, November 21, 2008
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The impact of disease‐causing defects is often not limited to the products of a mutated gene but, thanks to interactions between the molecular components, may also affect other cellular functions, resulting in potential comorbidity effects. By combining information on cellular interactions, disease‐‐gene associations, and population‐level disease patterns extracted from Medicare data, we find statistically significant correlations between the underlying structure of cellular networks and disease comorbidity patterns in the human population. Our results indicate that such a combination of population‐level data and cellular network information could help build novel hypotheses about disease mechanisms.
Most cellular functions are carried out by a complex network of genes, proteins, and metabolites that interact through biochemical and physical interactions (Gerstein et al, 2002; Barabási and Oltvai, 2004; Albert, 2005; Basso et al, 2005; Almaas, 2007; Alon, 2007; Yildrim et al, 2007). Therefore, disease‐causing defects may initiate cascades of failures that trigger the co‐emergence of multiple diseases in a patient, such as diabetes and obesity. Yet, given the environmental, lifestyle, or treatment‐related factors that all contribute to comorbidity, it is not obvious whether these cellular network‐based interdependencies manifest themselves at the individual or at the population level. Discovering such systematic correlations between cellular networks and disease patterns could potentially open new avenues for understanding the human interactome, and may help uncover hitherto unknown disease mechanisms (Ergun et al, 2007; Loscalzo et al, 2007; Braun et al, 2008).
The possibility that there may be systematic links between hereditary diseases, thanks to their common genetic origins, was postulated recently by Goh et al, who created a Human Disease Network (HDN) by connecting all hereditary diseases that share a disease‐causing gene according to the Online Mendelian Inheritance in Man (OMIM) database (Goh et al, 2007; Feldman et al, 2008). Although some of the diseases connected in the HDN captured well‐known comorbidity patterns, the functional relevance of the links in the network remains to be demonstrated, leaving open the question whether most diseases connected in the HDN exhibit significant comorbidity. Interestingly, the most disconnected disease class in the HDN is that of metabolic diseases. However, Lee et al recently showed that metabolic diseases can be also organized in a metabolic disease network if the enzymes and their associated diseases are linked through metabolic pathways (Lee et al, 2008). Most importantly, the study found that metabolic diseases connected through shared pathways tend to show significant comorbidity, suggesting that information encoded in the structure of the metabolic network is amplified, becoming discernible at the population level as comorbidity patterns.
Metabolic networks represent only one of the several networks functionally relevant to our understanding of cellular activity. Indeed, when it comes to cellular interactions of potential importance to human diseases, we need to consider protein–protein interaction (PPI) and coexpression networks as well as the links between diseases generated by shared genes. Therefore, earlier research raises an important question: are the cellular‐level relationships encoded by PPIs, coexpression, and shared genes amplified at the population level? That is, should we expect statistically significant comorbidity patterns for disease pairs that share a gene, whose proteins interact, or whose genes show high coexpression patterns? To answer these questions, we analyzed the large‐scale comorbidity pattern extracted from the US Medicare claims database and the gene‐‐disease association network from OMIM (McCusick, 1998). We find that cellular interaction links indeed manifest themselves at the population level, resulting in statistically significant comorbidity patterns. We quantify the relative magnitude of these correlations and discuss the current difficulties in mapping population‐ and cellular‐level data into each other, as well as the benefits of such an approach toward elucidating disease mechanisms.
Results and discussion
The starting point of our study is the Medicare claims database containing the diagnoses that Cij led to the hospitalization of N=13 039 018 elderly patients, each disease or condition identified by an ICD‐9‐CM code. We denote the incidence of disease i with Ii, and the number of patients who were simultaneously diagnosed with diseases i and j with Cij. The comorbid tendency between the two diseases can be quantified using either the relative risk, RR=Cij/Cij*, where Cij*=IiIj/N is the expectation value of Cij when the two diseases are independent, or the ϕ‐correlation defined as . When two diseases co‐occur more frequently than expected by chance, we have RR>1 and ϕ>0. Note, however, that although RR and ϕ are not independent of each other, each carries unique biases that are complementary. Therefore, we use both measures of comorbidity to ensure the robustness of our findings (see Supplementary information (SI) for further details). The disease‐‐gene associations used in the study were obtained from the OMIM database, which contains >4900 such associations as of October 2008. Although the disease‐‐gene record is far from complete, OMIM is currently the most complete repository of all known disease genes and their associated disorders.
It is important to note that disease names used in the Medicare database by the medical and the insurance communities (the ICD‐9‐CM scheme) and those used in the OMIM database by geneticists are not identical. Therefore, we enlisted a professional ICD‐9‐CM coder to manually map the OMIM disease names into ICD‐9‐CM codes and established connections between the genetic associations and the comorbidity measures (see Box 1 and SI sections S1 and S2 for more detail). On account of the discrepancies in disease names and the complex, hierarchical nature of the ICD‐9‐CM scheme, we recognize that the mapping is not perfect, and may contain debatable and occasionally erroneous ICD‐9‐CM‐to‐OMIM correspondence. Therefore, we are providing the mapping used by us in the SI, offering a chance for the community to improve on it in future studies.
Box 1 Didactic Box
Schematic description of the procedure used to connect comorbidity (calculated in the Medicare Layer, top) and genetic associations (given in the OMIM Layer, bottom) between a pair of diseases. Breast Cancer and Bone and Cartilage Cancer are treated as the example here, also presented in Figure 1B. In the Medicare Layer (top), each disease is represented by an ICD‐9‐CM code, a widely used hierarchical disease diagnosis code system. The incidence Ii of each disease (represented by a blue line) is found by counting patients in the Medicare database diagnosed with the corresponding ICD‐9‐CM code and its sub‐level codes (i.e. 174.1 is also counted as an incidence of 174 for breast cancer), while the co‐occurrence Cij (red line) of a disease pair is found by counting patients diagnosed with both codes. The comorbidity measures RR and ϕ can be calculated from these quantities and the total number of patients in the Medicare database (approximately 13 million). The associated genes of each disease are provided in the OMIM Layer (bottom, green lines). Because of differences in the disease‐labeling schemes in the Medicare (ICD‐9‐CM) and the OMIM databases (the codes are as given in Goh et al, 2007), we manually constructed a mapping between the two (grey lines). See Supplementary information for detail.
As OMIM comprises the set of hereditary or complex diseases with validated gene‐‐disease associations, it is anticipated that only a subset of ICD‐9‐CM codes would correspond to the diseases in the OMIM. Indeed, we find that, of the >12 000 available ICD‐9‐CM codes, 763 unique ICD‐9‐CM codes can be mapped to OMIM diseases. The fact that our analysis is limited to 5% of possible diagnosis codes contained in the Medicare database, could limit our population (patient) coverage. We find, however, that this is not the case: as Figure 1A shows, 90% of patients in the Medicare database are diagnosed with at least one disease whose ICD‐9‐CM code is contained in our mapping to the OMIM database.
We use the following three quantities to capture the cellular network‐level relationship between diseases i and j, as illustrated in Figure 1B for the case of breast cancer (ICD‐9‐CM 174) and cancer of bone and cartilage (ICD‐9‐CM 170.9, see also SI):
(i) nijg, the number of shared genes associated with both diseases i and j, which quantifies the potential common genetic origin of the two diseases (Goh et al, 2007);
(ii) nijp, the number of PPIs between the proteins of diseases i and j capturing the PPI network‐level relationships between them (Rual et al, 2005; Stelzl et al, 2005).
(iii) , the average Pearson correlation of coexpression between pairs of genes from each disease, capturing the degree to which the genes associated with the two diseases are coexpressed (Ge et al, 2005).
The main question can be formulated as follows: does the existence of these cellular‐level links (i.e., nijg>0, nijp>0, ij>0) between the two diseases increase the likelihood that individuals simultaneously develop both conditions? We start our investigation by measuring the Pearson correlation between the cellular variables (nijg, nijp, ij) and comorbidities (RR and ϕ) for 83 924 disease pairs. Of these, 2239 pairs are linked through either shared genes (nijg⩾1) or PPIs (nijp⩾1; 658 with shared genes, and 1873 with PPIs). In Figure 2A and Table I we present the Pearson correlation coefficients (PCCs) between the comorbidity measures and the genetic variables. Although ng, in general, has the highest correlation with comorbidity, we do observe positive PCC with all three variables.
There are numerous factors that determine whether two diseases co‐occur in a patient, some of which are environmental, lifestyle‐related or treatment‐induced. Our study captures only the role of the cellular network on comorbidity. The small magnitude of the correlations observed by us suggests that the cellular network offers only a small contribution to the observed comorbidity. Note, however, that placing significant emphasis on the magnitude of these correlations is premature, as two known effects limit the correlations observed by us. First, the magnitude of the correlation is limited by the predictive power of specific genetic mutations catalogued in the OMIM database, and the likelihood of a patient developing a particular disease. Indeed, it is known that genetic mutations result in an increase of at most a few percentage points in the likelihood of an individual developing a specific complex disease (Loscalzo, 2007) and the correlations observed by us cannot exceed the known disease‐‐gene correlations. Second, the correlations are further limited by the noise in the mapping between the OMIM diseases and the ICD‐9‐CM codes. As we noted, there is inherent ambiguity both in the mapping as well as in the process of assigning a particular diagnosis to specific ICD‐9‐CM codes in hospitals. Each instance of such misdiagnosis or mapping ambiguity decreases the magnitude of the observed correlations. Therefore, at this point it is not the magnitude, but the statistical significance of the correlations that we can rely on. As summarized in Table I, the observed correlations are statistically significant.
To quantify the degree of comorbidity caused by the observed correlations, we measured the average comorbidities 〈RR〉 and 〈ϕ〉 for disease pairs that are connected at the cellular network level. Compared with the entire set of 83 924 pairs of hereditary diseases considered in our study, we find (see Figure 2B; Table II) a two‐ to four‐fold increase in the average comorbidity in disease pairs that share genes (nijg⩾1), indicating that if a patient develops a particular disease associated with a gene or multiple genes in the HDN, then they have a two‐fold higher chance of developing another disease mapped to one or more common genes in the HDN, compared with diseases that are not. An increased comorbidity is also observed for disease pairs linked through PPIs (nijp⩾1) and high coexpression (ij ⩾geqslant 0.5).
The observed correlations between the cellular links and comorbidities raise a related question: would disease pairs that are more interconnected than others (i.e., have larger nijg, nijp, or ij) show higher comorbidity? To address this, in Figure 2C we show that comorbidity increases rapidly with the number of shared genes: sharing two or more genes (nijg⩾2) results in nearly a five‐fold increase in comorbidity compared with hereditary disease pairs that do not share genes. An increase in comorbidity is observed with increasing nijp and ij as well (Figure 2D and E), although the effect is weaker than that observed for nijg, which is not unexpected given the smaller impact that nijp and ij have on comorbidity in comparison with nijg.
Note that the average comorbidity measured between all pairs of diseases is >1 (Figure 2B), indicating that many patients develop multiple disorders, whether or not the specific diseases are linked at the cellular level. Such correlations have been observed in other studies focused on comorbidity patterns (Rzhetsky et al, 2007; Hidalgo et al, 2009). These overall comorbidity patterns are not particularly surprising considering that the Medicare population is 65 years of age or older, the age at which individuals do develop multiple disorders. Thus, the overall comorbidity represents the baseline against which we can assess the impact of the genetic and cellular networks. It is reassuring, therefore, that hereditary diseases that are linked in the HDN (and thus at the cellular level) show comorbidity higher than the baseline 〈RR〉=1.92±0.01 and 〈ϕ〉=(1.84±0.02) × 10−3 observed for the set of all disease pairs.
Despite the significant increase in 〈RR〉 and 〈ϕ〉, there are many disease pairs that share genes yet fail to show significant comorbidity. We hypothesize that this is, in part, because of pleiotropy, which in this context means that different mutations on the same gene can have different pathological effects on a protein (Dudley et al, 2005), thereby predisposing an individual to different disorders. In general, we expect that disease pairs associated with mutations on the same functional domain of the shared protein show higher comorbidity than disease pairs whose mutations occur in different functional domains. To test this hypothesis, we identified the functional domains of disease‐causing mutations on shared genes using the Pfam database (Finn et al, 2006). In agreement with our hypothesis, we find higher 〈RR〉 and 〈ϕ〉, for disease pairs whose mutations are on the same domain of the shared gene, compared with disease pairs whose mutations are in distinct functional domains (Figure 2B).
The observed correlations suggest that a combination of disease data and cellular network information may assist us in identifying new comorbidity patterns alongside their potential genetic origin. Indeed, upon inspection of the 2239 disease pairs that are genetically linked (i.e., nijg⩾1 or nijp⩾1), we find several disease pairs whose comorbidity patterns are already well known to the medical community, such as diabetes and obesity (Evans et al, 2002), or breast cancer and osteosarcoma (Knowling and Basco, 1986). At the same time, due to the aforementioned mismatch between disease names used by clinicians (within the ICD‐9 coding scheme) and by geneticists (within the OMIM tabulation), several highly comorbid disease pairs are readily anticipated (such as diabetes and hypoglycemia, as hypoglycemia is a common side effect of the treatment of diabetes) or cases in which one disease is a broader version of the other (such as mononeuritis and hereditary peripheral neuropathy). Such mapping limitations notwithstanding, we find several interesting disease pairs that are linked at the cellular level and also show significant comorbidity. For example, consider Alzheimer's disease (ICD‐9‐CM 331) and myocardial infarction (ICD‐9‐CM 410.9), for which earlier comorbidity studies were either inconclusive or contradictory (Bursi et al, 2006). As Figure 3A shows, we not only find statistically significant comorbidity (P≈10−5) between the two, but the figure suggests that the shared ACE and APOE genes may contribute to the observed effect. Similarly, we observe significant comorbidity (P≈10−148) between autonomic nervous system disorder (ICD‐9‐CM 337.9) and carpal tunnel syndrome (ICD‐9‐CM 354, Figure 3B). A known mechanism is L‐chain amyloidosis, which may affect the autonomic nervous system and causes carpal tunnel syndrome when the amyloid infiltrates the flexor retinaculum of the patient's wrist (Haan and Peters, 1994). Figure 3B, however, suggests that a PPI between the associated genes of each disorder may also play a role in the observed effect. Although there may be additional possible physiological or social explanations for some of the observed comorbidities (see SI), the method described above has the potential to offer new, testable hypotheses about the biological basis of disease interrelationships. These examples were selected only to demonstrate the potential of the combined investigation of the network and population‐level data in identifying potentially interesting disease pairs worthy of further study. A more detailed description of these disease pairs, along with the complete list of the 2239 genetically linked disease pairs and their genetic associations are provided in the SI.
The main finding of this paper is that health care and treatment data on a large number of individuals offer information useful to systems biology that can complement the information from the well‐established genomic studies. Indeed, Medicare and insurance databases already collect the health care history of millions of individuals, allowing us to uncover the correlations in the occurrence of various diseases. In parallel, increasing knowledge about the molecular origin of disease indicates that many disorders are rooted in defects in gene products that are part of the same cellular network, raising the possibility that these diseases should co‐occur in the same individual. Admittedly, much of the currently available network data are incomplete and probably noisy. We may be approaching a tipping point, however, where we have acquired sufficient knowledge of human cellular networks to begin understanding the way a disturbance in the networks may contribute to the development of a disease and suggest potential disease‐modifying factors.
To test the validity of this hypothesis, here we correlated cellular level information for human cells, namely data on shared genes, PPIs, and coexpression patterns, with comorbidity data obtained from the Medicare database. Despite the aforementioned limitations of the mapping and the data collection process, we found statistically significant correlations between cellular interactions and comorbidity patterns. We also found that disease pairs with higher correlations tend to be linked more strongly in the cellular network.
Although our work was mainly driven by the desire to uncover evidence that cellular information is amplified in the human population and thus can be detected from patient data, our results point to the potential usefulness of our approach in uncovering disease mechanisms. Indeed, we discuss two disease pairs in which the network‐based information offers a plausible mechanism for statistically significant comorbidity patterns. These results suggest that Medicare and other insurance databases could play an increasing role in future studies of the systems biology of human cells and diseases.
Materials and methods
Data sets
We used the HDN from Goh et al for disorder‐‐gene associations (Goh et al, 2007), updated based on the version of the Morbid Map from OMIM at the time of the study. The most up‐to‐date version can be found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim. The PPI data were taken from Rual et al (2005) and Stelzl et al (2005). The genetic coexpression levels were calculated on the basis of an Affeymetrix microarray data (Ge et al, 2005) (see www.affymetrix.com). Protein domain information is available on UnitProt (http://www.uniprot.org/) and Pfam (http://www.sanger.ac.uk/Software/Pfam/).
Estimating P‐values and errors
The P‐values for the PCCs shown in Figure 2A and Table I were calculated by a Monte Carlo sampling method. We generate a randomized sequence of the genetic variables and calculate its PCC with comorbidity. After 2 million randomizations, the P‐value is the fraction of the total trials that resulted in a PCC that is larger than what was observed.
As RR and ϕ are monotonically increasing functions of Cij, their one‐sided P‐value is equal to the sum of probabilities that the co‐occurrence Cij is larger than the actual value. It can be obtained using standard computational software such as Mathematica (www.wolfram.com) by approximating the binomial distribution generated from the number of patients N and Cij*=Np=IiIj/N as a Poisson distribution, and therefore
The errors on the comorbidity values (Figure 2) were calculated using the bootstrap method based on resampling (Efron, 1979; Newman and Barkema, 1998).
We thank Quan Zhong, Cesar Hidalgo, Nick Blumm, and Marc Vidal for useful discussions. This research was supported by JSMF 220020084, NSF ITR DMR‐0426737, NIH CEGS‐1P50HG4233/CFDA #93.172, NIH U01 A1070499‐01/111620‐2, and NIH U56 CA113004/sub MGH.
Conflict of Interest
The authors declare that they have no conflict of interest.
Supplementary Information
Supplementary Information
Supplementary Information and Supplementary Figure S1‐S2 [msb200916-sup-0001.pdf]
Supplementary Table 1
Mapping between OMIM and ICD‐9‐CM [msb200916-sup-0002.xls]
Supplementary Table 2
Comorbidity between genetically connected diseases [msb200916-sup-0003.xls]
Supplementary Table 3
Disorder‐Genetic Associations [msb200916-sup-0004.xls]
- Copyright © 2009 EMBO and Nature Publishing Group


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Holiday season is here and I often hear my daughter asking for some yummy snacks. I prepared chana masala for my hubby's tiffin box and was left with some boiled chick peas, so I came up with this recipe.
Though my daughter N is not very fond of chick peas but she loved these fried buttons.
Boiled Chick Peas - 1 cup
Large bread slices- 3
Besan - 2 tblsp
Milk - 3 tblsp
Lemon juice - 1 tblsp
Amchoor ( Mango powder) - 1/2 tsp
Salt, Chilli powder - to taste
Coriander leaves chopped - 1 tblsp
Oil - To fry
Procedure :
- Grind the chick peas without any water.
- Soak the bread slices in milk just for few seconds then squeeze the bread.
- Mix the chick peas, bread, besan, lemon juice, coriander leaves, amchoor, salt and chilli powder. Mix everything together to form a smooth dough. The dough will look like this-
- Make small balls of the mixture and flatten little to look like buttons.
- Heat oil and fry the buttons on medium to high flame till nice golden brown.
- The buttons will disintegrate if the flame is low.
Enjoy the buttons hot with some tomato ketchup.
Sending this to Susan's MLLA event hosted by Priya of mharorajasthanrecipes.
Also sending this to Any One Cook :Series 9 started by Ayeesha of Taste of Pearl City.


text:
Q: Am I registered to vote?
A: Click here to check if you're registered.
Q: When is the deadline to register to vote?
A: Monday, October 7, 2019. 29 days before election day on Monday November 5, 2019
Q: How can I register to vote?
A: Register online here.
You may also call the Orange County Supervisor of Elections if you have any questions (407) 836-2070 or 407-836-8683
Q: Should I bring ID to the polling place?
A: All voters who appear at a polling place for the first time must show proof of identification.
Acceptable forms of photo identification include:
- Florida driver's license
- Florida identification card issued by the Department of Highway Safety and Motor Vehicles
- United States passport
- Debit or credit card
- Military identification
- Student identification
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- Public assistance identification
- State of Florida concealed weapon or firearm license
- Employee identification card issued by any branch, department, agency or entity of the Federal Government, the state, a county, or a municipality
- Veteran health identification card issued by the United States Department of Veterans' Affairs
Q: How can I vote with an Absentee Ballot?
A: Click here for an Absentee Ballot application form. Absentee Ballot applications must be received by county board of elections by 5:00 p.m. March 6th.
Q: When are Absentee/Vote By Mail Ballots due?
A: Absentee ballots must be received in the Elections Office no later than the sixth day prior to the election by 5:00pm.
The vote-by-mail ballot packet will include instructions on how to mark your ballot, how to complete the required voter's certificate, and how to properly return your ballot to the elections office. The deadline to return Voted ballots to the Elections Office is no later than 7:00 p.m. election night for it to be counted.
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Your vote-by-mail ballot will not count if the signature on the return envelope's voter certificate does not match the signature on file. Signatures often change due to age, injury or illness. Update your signature by completing a Florida Voter Registration Application form.
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Paid for by Aretha Simons for City of Orlando Mayor


text: The fact is, many of us spend an egregious amount of time using social media (sharing tweets, commenting on FB posts, etc.). We lose ourselves in our ever updating feeds. The more curious among us even try to quantify the hours and minutes spent on social networking each day. But I've often wondered: What is our behavior … Read more


text:
LAM55: Pedrogão Rustic House
Pedrógão Grande, Leiria
Old house with two floors, land with trees and water
Property Description
Old house with 2 levels that can be convert into a house with 3 bedrooms. There's permission to extend the house. A part of the land is for agriculture and have water spring.
2ha of land with lot of pine trees, oak trees and fruit trees.
This property is 500m from the main road, so is very quite place, the electricity is 500m away, but is easy to make the connection, water is on the property. with a lot of sun,
Situate in Pedrogão Grande at 5km from the village. There are shops 2km away from the house, the lake is just 3km away where you can fish.
Property Location
Add to favoritesNº of Houses: 1Land Size: 20,000m2 / 2ha / 4.94ac
Price: €55,000
Nearest Accommodation
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• Zest Car Rental
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Send Enquiry or Request a Viewing
Email: firstname.lastname@example.com
Email our Team for support and other questions, or visit the Contact page.
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access only on foot
bread oven
central heating
flat land
garage / workshop
good access
grape vines
mains electricity
multiple houses
pond / lake
solar electricity
solar water heating
swimming pool
temporary home
terraced land
- citrus trees
- fruit trees
- olive trees
vegetable garden
- spring
- stream / river
- water mine
- watermill
- well
wind power
woodstove / fireplace


text:
Series: Chasing the Dream #1
Genre: Contemporary Romance, New Adult, Fiction
Publication Date: June 17, 2014
Publisher: Elizabeth Briggs Books
Page Count: 311
Source: Oops I Read a Book Again
Format: eARC
Goodreads ~ Amazon ~ B&N ~ iTunes ~ Kobo ~ Smashwords ~ The Book Depository
Synopsis: Music major Maddie Taylor just finished her junior year of college and has a summer internship lined up with the LA Philharmonic, yet every night she practices guitar and secretly dreams of a louder life. But geeky girls like her don't get to be rock stars. That is, until tattooed singer Jared Cross catches her playing guitar and invites her to join his band on The Sound, a reality TV show competition.
Once on the show, Maddie discovers there's more to Jared than his flirty smile and bad boy reputation – and that he's just as big a geek as she is. With each performance their attraction becomes impossible to ignore, but when the show pressures them to stay single they're forced to keep their relationship secret.
As the competition heats up, Jared will do whatever it takes for his band to win, and Maddie must decide if following her dream is worth losing her heart.
About the Author: Website ~ Twitter ~ Facebook ~ Tumblr ~ Instagram ~ Pinterest
Elizabeth currently works with WriteGirl to mentor at-risk or pregnant teen girls in writing, to help them get through high school and into college. She also volunteers with Bichon FurKids to help rescued dogs find a new, loving home. She previously worked as an intern for literary agent Jill Corcoran of Jill Corcoran Literary Agency, an intern for Entangled Publishing, and an editor for Curiosity Quills Press.
Elizabeth is represented by Kate Schafer Testerman of KT Literary and is a member of SCBWI and RWA.
Jared's guitar was beautiful, with a smooth white faceplate, gleaming struts, and a shiny fingerboard. My fingers itched to touch the silvery strings, to form a chord and let it ring out through the amp, to hear what it sounded like without all the other instruments accompanying it. And if I was honest, I wanted to close my eyes and pretend I was on stage, playing for a crowd, hearing them scream for me. The longing I felt every time I went to a concert stirred up in me again. It wouldn't hurt if I played one chord, right? That was it. One chord, and I'd put it back. No one would ever know.
Before I could stop myself, I picked up the guitar and threw the strap over my head. It settled against my shoulder, and with one hand on the fret board and the other on the strings, I was home. I closed my eyes, picturing Jared when he was on stage and how his talented fingers had moved across the guitar. I imagined him singing my favorite song of theirs, "Behind the Mask," and the words and notes melted together in my head. I strummed the guitar, the sound ringing from the amp, the vibrations traveling up the ground and into my feet. God, I loved this guitar. It sounded just as good as my own, if not better.
Now that I had the guitar in my hands, the compulsion to play was irresistible. What was one more chord, right? I was alone and the room was soundproof. The door had locked behind me. Kyle was dealing with Becca, and he'd given me permission to come in here anyway.
I knew it was a bad idea. I knew I should put the guitar down and walk out of the room. But I started strumming anyway.
I was hesitant at first, but once I started, I couldn't stop. My hands found the chords automatically, and the words flowed out of me with the music. Exhilaration swept through me with each note, and I closed my eyes and let the song take me away. Soon I was belting out the words, shredding the guitar like I was on stage playing for a massive crowd. I'd never do this in front of anyone else, but here, alone with this guitar, I could pretend. I could let myself go.
And then I opened my eyes and wanted to die.
Jared stood in front of me, his eyes wide and mouth open slightly. He must have come in while I was playing. How much did he hear? Or worse, see?
My fingers slipped off the strings with a screech, and I nearly dropped the guitar. Thank god for the strap. "I'm so sorry. Kyle gave me the key and I was just—"
There was no way to explain what was going on, so I shut up. I'd been singing his lyrics, playing the song he'd written. Not to mention, I'd been using his guitar. That was like wearing someone else's underwear. You didn't just play another person's guitar without their permission.
I yanked the guitar off and tried to put it back, but knocked the stand over instead. Hands shaking, it took me two tries to right it again, all while Jared stood there, gaping at me. Why didn't he say anything? Was he so angry he couldn't speak? I set the guitar down carefully, then backed away like it was on fire—and ran straight into the drum set. Cymbals crashed as I fell against it, knocking the equipment all over the floor. Great, now he must think I'm a stalker and a complete klutz. I jumped up too fast, and my legs were so unsteady I started to topple over toward the table. Jared caught me before we had another disaster, his hands gripping my arms to balance me.
"You okay?" he asked, his blue eyes holding mine and making my heart pound even faster. If I stared into those eyes too long, I'd fall into them completely.
Pro ~ Romance: I have to admit something, there is insta-love in this novel, and not only is insta-love, it is obvious insta-love. The synopsis clearly states that Maddie and Jared are the two protagonists that fall in love over the course of the story, and I also have to say that the plot is driven by romance. You're probably sitting there wondering why on earth romance is in the "Pro"section if I'm busy saying there is insta-love that drives the plot. The answer to your wonderings (totally not a word) is, "The insta-love actually works." I adored Maddie and Jared as a couple, and was routing for them the entire time. Despite screaming fangirls and sneaky producers, their ship did not sink.
Con ~ Maddie: While I liked who Maddie was as a person, I disliked some of her decisions and judgements. For example, when she was asked to join Villain Complex, I didn't feel that she pondered the decision long enough. Sure, she had doubts and was apprehensive about the situation, but I felt that she agreed to fast because of her attraction to Jared. Then, when she joined the show, she had to give up her internship at the LA Philharmonic which she had been so excited and went through such an intense elimination process in order to join. Even though she had her loyalty to Kyle, Jared, and the commitment she made to the band, it still seemed so sporadic and hasty how she just dropped everything for the show. Nearing the end of the book, Maddie makes a particularly crazy decision which effects not only her, but a lot of people around her, and doesn't help her reputation. She has regrets of course, but things just seemed so hasty.
Pro ~ Vivid Descriptions: Something I read in an interview in June was that Elizabeth Briggs could not include song lyrics, so she learned how to play all the songs she featured in More Than Music in order to describe playing the songs as well as possible. She did a superb job with this, and a good example of this is found in the excerpt I posted (why else would I have posted that specific one?). Brigg's vivid descriptions also helped a lot in the romance department.... if you know what I mean. Certain scenes between Maddie and Jared were extremely intense and not advisable for younger readers.
Con ~ Lack of Information on Supporting Characters: The reason Maddie was invited into the band in the first place, and how she even met Jared in the first place was because of Kyle. Kyle is one her friends from college and the real instigator of the entire story. Yet, after the first six or seven chapters, it's almost as if he disappears and only shows up when he's needed to be the "bad guy" of the situation, and of course to play in the band. Luckily, Elizabeth Briggs is scheduled to release two novellas, one that will focus on Kyle and another that will focus the other band member - Hector.
Pro ~ Music: What drew me into More Than Music was the fact that the characters had to go through a reality television competition that was based off of The Voice. You may not know this about me, but I am a very avid fan of The Voice, I love watching the four coaches every Monday and Tuesday nights and all the amazing performances. In terms of how The Sound worked, it is almost identical to The Voice in terms of rules and regulations, but instead of just one or two people performing, there are whole bands.
Con ~ Predictability: The plot, characters, and even some dialogue in More Than Music was predictable. I don't want to spoil anything for you, but the end was very predictable, as well as the chain of events going on for the duration of the story. You kind of knew what would happen because it had to happen in order for the story to continue.
Pro ~ Pacing: The last thing I loved about More Than Music was how quickly the story went by. I literally started the book on a whim.... you know, as much of a whim as you can read a book that has a to be read by date, directly after I finished Falling Into Place by Amy Zhang. I would totally recommend this novel to other people, which is saying a lot because you would expect the book hangover to be really bad after Falling Into Place and that nothing could compare, but this one did. As I was saying, I picked this book up around 11 at night, and finished it around 2. I just kept reading, and everything was so fast paced, I hadn't noticed the time.
Conclusion: More Than Music is a fast-paced read full of romance, vivid descriptions, and of course... music.


text:
As expected the four trading days in the prior week rose (slight upside bias), but less than 1% for most indexes.
TSI is showing a negative cross. The 4.5 month cycle and 10 week cycles are into what should be a stronger down part of those 2 cycles. The 5 week cycle is topping and should be down by mid week. The nine month is still up, but should be losing upside momentum as it seeks its top.
So it appears any upside will be limited and possibly we see a slight downside bias by week's end.
GL traders


text:
The Evita® 2 dura is an advanced intensive care ventilator with simple and versatile operation, a highly responsive flow trigger, and an open breathing system that gives both the patient and the clinician "Room to Breathe". The standard colour screen provides enhanced monitoring. The Evita® 2 dura can be custom built to your order. Features like enhanced graphics, integrated CO2 monitoring or specialised modes like APRV can be added to the system at any time without changing the profile of your device.
The Evita 2 dura provides patient and ventilator-related monitoting with user interaction reduced to a minimum. The high-resolution full-color sereen displays comprehensive information on a patient's status, always showing two ventilation curves and six monitored values, and the screen configuration can be customized to show the most important values for a particular ICU.
Mechanical Ventilation
Modes of Ventilation
Components of Ventilator System
Technologies and Jargon
Copyright © 1992Soma Technology, Inc.


text:
A shorter crisp version (about 600 words) is published in the FMLM (blog http://www.fmlm.ac.uk/blog/makani-hemadri/end-management) for which this topic was originally written. This is the rambling 1500 word extended narcissistic version. You are welcome to it ...
It is important to read Alan Murray's 'The End of Management' Corporate bureaucracy is becoming obsolete. Why managers should act like venture capitalists; in the WSJ. Here is the link: http://online.wsj.com/article/SB10001424052748704476104575439723695579664.html
Once you have read this blog post gets its context and then you can read this either as a commentary of the WSJ article as relevant to NHS or on its own. This blog is deliberately off-key, the topic is such, bear with me. Compared to many healthcare systems we do quite well in the NHS. Could we do better? Of course yes but how we do that will define our future.
We are the management and we will tell you how to end management!?!?!
At a broader level, in the NHS there are no examples that I can think of where corporate structure or management has been 'ended'. The previous government did good work with top down waiting times and so on; the present government is attempting top down radical change in organisational structures. The government is trying to get us do differently. When individuals try to do something creative, the organisations and the NHS as a whole tries to look at 'where and how it fits in with the overall plan'. But in the public sector there is the government not just wanting us to do different but also telling us how precisely to do it; with organisations 'encouraging innovation and creativity' only if it fits in with pre-defined policies. But that is what modern business is trying not to do; modern thinking in management is not telling people what to do but to let people to do things first and the management to amplify the good ideas.
Thinking of me vs thinking of you
At the narrower level, trainees (I am talking about all trainees in the clinical areas- not just doctors) are taught to think of how they are learning and improving themselves; never to explicitly think about their contribution to the organisation. In fact, often people think that their contribution to healthcare as such starts only when they stop becoming trainees. By that time the mind set becomes so fixed in thinking inwardly about the self and not outwardly about others that it becomes very difficult for the rest of their lives. Careerism becomes the mantra for many people in healthcare; we always thought this was the case in the private sector - true but that trend is changing in some areas.
Best with limits
This leads to people taking very defensive attitudes. Most people in healthcare management are either numerically shy or numerically illiterate. They are unwilling to make a personal numerical prediction on their or their department/division/directorate's improvement based on a measurable internal parameter due to the fear that they may be unable to stand by it. In any case most of the numbers are geared towards predefined reporting parameters. People who work in the NHS also seem to think that they are somehow very altruistic and have a high sense of entitlement. That attitude is even more profound in the clinicians with clinicians tending to believe that they express their altruism by their very individualistic approaches to healthcare. It is also possible that there are certain kind of people who are drawn to public services (possibly risk averse, change shy, rule-bound, authority loving, service minded and so on) and it would be difficult to use the same methods as for instance in Google to achieve a new management approach.
At both the above levels, healthcare and NHS is thought to be too important and too costly to be creative or innovative; the phrase used is 'risk'. Healthcare especially in Europe and even more so in UK has innumerable external controllers and bodies telling people what to do and how to do it that it simply chokes off creativity even before it begins. In other industries there is an obligation to do some degree of statutory reporting with no real controls on how they do their business.
So, it seems like what the above WSJ article is saying is not possible in UK healthcare at all. There seems no space that is available or can be created for those concepts to happen without falling foul of something or someone. But there lies the opportunity as well to 'end management' and create self-sustaining systems.
Blue skies
Hence, I can now boldly enter the imaginary world to explore how the 'wisdom of the crowds' can be harnessed. I think the way to do it is to disengage from current conventions and demonstrate its success. That does not mean rebelling, non-cooperating, behaving illegally, not concentrating, becoming disenchanted or any such thing. It is using our own methods to satisfy our requirements and our clients' requirement rather than using a method or doing a thing to satisfy an external definition.
For instance when the roads around Birmingham were choking instead of building a new road, they opened the hard shoulder to traffic which in other roads is actually illegal; peak time traffic situation has improved since in that area. Compare that with an example of the situation in some hospitals where they buy yet another business intelligence interface/data-mining tool to provide information at service line specialty level when the managers and clinicians often feel that human connectivity was the issue that needed resolving to enable their older software to be used effectively. Often the tool is not really the problem, our thinking is.
Let us assume for example that one of our services is not accredited by some specialty society because we did not meet one or more of their requirements in the way they wanted. Normally the tendency would be either to stop that service or to work very hard to meet that accreditation standard. However, if our results in that particular specialty or aspect is better than anywhere else, would we as an organisation, anyone in the specialty society or the general society as a whole be unhappy? Certainly not. In this scenario the badge of not being accredited becomes a badge of honour. The problem is we do not think like that in the NHS. We probably should.
Like the Birmingham roads, what 'illegal' things could we do to make ourselves better?
Obviously we should disengage and develop only if it is beneficial to our hospital and patients and we are able to track it and prove it contemporaneously.
Is this an example of wisdom of the crowds in the real world of healthcare?
Finally let me try a hypothetical yet hopefully practical proposition to disengage and demonstrate. There is a focus on Unplanned emergency re-admissions and we may not get paid for such re-admissions. I am aware of some of the things that we have started doing to tackle this issue. Let me put to you a potentially disruptive solution in the 'end of management' mode
a) not offering routine follow-ups for any patient who is discharged from the ward (medical, surgical, post-operative)
and instead
b) Guaranteeing a clinic slot within a defined time (48 hours to one week as agreed) should the patient choose to contact us.
My hypothesis is, this approach will reduce unplanned emergency readmissions as the issue is often/mostly to with patient concerns on access (rather than real life-threatening matters); the 'routine' follow up itself is mostly to satisfy clinicians habit rather than a scientific finding that all complications in all patients happens precisely 3 months after seeing the doctor and hence patients need a 3 months appointment. This will also clear up the 'congestion' we have in our clinics.
Okay, where is the 'wisdom of the crowd' here? The crowd in our example is the patient; and the wisdom is the patients' knowledge about their own health on what is wrong with them and they should be able to access us when they find something wrong with them. This is of course one step further than the current thinking on 'crowd' which is usually the employees in a large organisation. We even need to change the definition of crowd to suit our requirement.
Rambling ambiguity and the threads of new systems
We can predict that the conventional management methods will not work in the 21st century. End of management as we know it is not chaos as many would like us to believe. New models are not apparent or clear yet. Perhaps there may not be one new model; possibly there may not be a well defined model at all. There are emerging themes; democratisation of data, data mining, crowd sourcing, coping with anti-knowledge, cloud care and dumb-terminals, many more............ It is not these themes that are important; it is how we implement these themes that are relevant. We can be told how to do it thus not 'ending management' or we can show how we do it.
Thank you for getting to this sentence of the blog. If you thought this was rambling ambiguity, I am grateful for your attention and will do better next time. If there are some threads that we can build on then I have achieved my aim.
Follow me on twitter @HemadriTweets


text:
Visit / Permit for Entering Hong Kong
1. Check out the Visit Visa / Entry Permit Requirements
According to the Immigration Department's Visit Visa / Entry Permit Requirements for the Hong Kong Special Administrative Region, there is a list of countries/ territories which always require a VISA. Please check if you need a VISA to enter Hong Kong.
Please read through all the details and conditions stated in the captioned website.
2. Guidebook for Entry for Visit/Transit in Hong Kong
This guidebook sets out the entry arrangement for persons who require a visa/entry permit to visit/transit the HKSAR. You can find application procedures, travel documentation requirements, etc, in this guidebook. To speed up the application, you can download the application form in advance. Please note that this entry arrangement does not apply to Chinese residents of the Mainland and Taiwan (other than People's Republic of China passport holders and Chinese residents of Taiwan living overseas).
3. How can HKTDC help?
To assist your visa application, the fair organiser(s) can issue you an official invitation letter. Please send us a request at least two months before the Fair begins.After receiving and verifying the requested documents, we will send you the invitation letter in one week time. It will normally take four to six weeks for the Immigration Department to process a visit/transit visa/entry permit application upon receipt of all the required documents.


text:
In the stage version of THE LION KING there are two children's roles: Young Simba and Young Nala.
We are always looking for children aged 8-11 to join our Cub School training programme, which will teach them skills in acting, movement and singing to later audition to potentially play these roles professionally in the West End or on Tour.
Role Descriptions
Young Simba (Young Lion)
Young Simba is brave, athletic and energetic.
Young Nala (Young Lioness)
Young Nala is brave, athletic and energetic.
Applicants for Cub School must be between ages 8 and 11 and below 143cm (4'8") in height.
Children are not required to prepare anything in advance of the Cub School auditions. One parent or guardian must accompany each child to the audition and stay on the premises until the audition has ended.
Open Auditions for Cub School
The next auditions will take place on Saturday 9th March 2019
To register for these auditions please contact: email@example.com with the following information:
· 2 clear photos (head shot and full length)
· Child's full name –
· Age –
· Height –
· Parent email –
· Parent Telephone number –
· Address (inc post code) –
PLEASE NOTE: All children must live and be educated within a commutable distance of central London. (Maximum 1 hour)
Cub School takes place once a week after school during term time. It is a free performance-training programme from which the roles of Young Simba and Young Nala are cast. During the programme, teachers who are associated with THE LION KING train children in the disciplines of dance, voice and acting. Training lasts for a minimum of 8 weeks to a maximum of 6 months. Whilst winning a place in Cub School does not guarantee a part in the stage musical, it has proven to be excellent training for young people with the ambition to work on stage.