text:
|View/Edit Human
|View/Edit Mouse
Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein which in humans is encoded by the ADIPOQ gene.[3] It is involved in regulating glucose levels as well as fatty acid breakdown.
Adiponectin is a 244-amino-acid-long polypeptide (protein). There are four distinct regions of adiponectin. The first is a short signal sequence that targets the hormone for secretion outside the cell; next is a short region that varies between species; the third is a 65-amino acid region with similarity to collagenous proteins; the last is a globular domain. Overall this protein shows similarity to the complement 1Q factors (C1Q). However, when the 3-dimensional structure of the globular region was determined, a striking similarity to TNFα was observed, despite unrelated protein sequences.[4]
Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid oxidation.[5] Adiponectin is exclusively secreted from adipose tissue (and also from the placenta in pregnancy[6]) into the bloodstream and is very abundant in plasma relative to many hormones. Many studies have found adiponectin to be inversely correlated with body mass index in patient populations.[7] However, a meta analysis was not able to confirm this association in healthy adults.[8] Circulating adiponectin concentrations increase during caloric restriction in animals and humans, such as in patients with anorexia nervosa. This observation is surprising, given that adiponectin is produced by adipose tissue. However, a recent study suggests that adipose tissue within bone marrow, which increases during caloric restriction, contributes to elevated circulating adiponectin in this context.[9]
Transgenic mice with increased adiponectin show impaired adipocyte differentiation and increased energy expenditure associated with protein uncoupling.[10] The hormone plays a role in the suppression of the metabolic derangements that may result in type 2 diabetes,[7] obesity, atherosclerosis,[5] non-alcoholic fatty liver disease (NAFLD) and an independent risk factor for metabolic syndrome.[11] Adiponectin in combination with leptin has been shown to completely reverse insulin resistance in mice.[12]
Adiponectin is secreted into the bloodstream where it accounts for approximately 0.01% of all plasma protein at around 5-10 μg/mL (mg/L). In adults, plasma concentrations are higher in females than males, and are reduced in diabetics compared to non-diabetics. Weight reduction significantly increases circulating concentrations.[13]
Adiponectin automatically self-associates into larger structures. Initially, three adiponectin molecules bind together to form a homotrimer. The trimers continue to self-associate and form hexamers or dodecamers. Like the plasma concentration, the relative levels of the higher-order structures are sexually dimorphic, where females have increased proportions of the high-molecular weight forms. Recent studies showed that the high-molecular weight form may be the most biologically active form regarding glucose homeostasis.[14] High-molecular-weight adiponectin was further found to be associated with a lower risk of diabetes with similar magnitude of association as total adiponectin.[15] However, coronary artery disease has been found to be positively associated with high molecular weight adiponectin, but not with low molecular weight adiponectin.[16]
Adiponectin exerts some of its weight reduction effects via the brain. This is similar to the action of leptin,[17] but the two hormones perform complementary actions, and can have synergistic effects.
Adiponectin binds to a number of receptors. So far, two receptors have been identified with homology to G protein-coupled receptors, and one receptor similar to the cadherin family:[18][19]
- Adiponectin receptor 1 (AdipoR1)
- Adiponectin receptor 2 (AdipoR2)
- T-cadherin - CDH13
These have distinct tissue specificities within the body and have different affinities to the various forms of adiponectin. The receptors affect the downstream target AMP kinase, an important cellular metabolic rate control point. Expression of the receptors is correlated with insulin levels, as well as reduced in mouse models of diabetes, particularly in skeletal muscle and adipose tissue.[20][21]
Adiponectin was first characterised in 1995 in differentiating 3T3-L1 adipocytes (Scherer PE et al.).[22] In 1996 it was characterised in mice as the mRNA transcript most highly expressed in adipocytes (Maeda, 1996 (citation #1, below)). In 2007, adiponectin was identified as a transcript highly expressed in preadipocytes[23] (precursors of fat cells) differentiating into adipocytes.[23][24]
The human homologue was identified as the most abundant transcript in adipose tissue. Contrary to expectations, despite being produced in adipose tissue, adiponectin was found to be decreased in obesity.[5][7][17] This downregulation has not been fully explained. The gene was localised to chromosome 3q27, a region highlighted as affecting genetic susceptibility to type 2 diabetes and obesity. Supplementation by differing forms of adiponectin was able to improve insulin control, blood glucose and triglyceride levels in mouse models.
The gene was investigated for variants that predispose to type 2 diabetes.[17][23][25][26][27][28] Several single nucleotide polymorphisms in the coding region and surrounding sequence were identified from several different populations, with varying prevalences, degrees of association and strength of effect on type 2 diabetes. Berberine, an herbal folk medicine, has been shown to increase adiponectin expression[29] which partly explains its beneficial effects on metabolic disturbances. Mice fed the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have shown increased plasma adiponectin.[30] Curcumin, capsaicin, gingerol, and catechins have also been found to increase adiponectin expression.[31]
Phylogenetic distribution includes expression in birds[32] and fish.[33]
Adiponectin effects:
- glucose flux
- decreased gluconeogenesis
- increased glucose uptake[5][17][26]
- lipid catabolism[26]
- β-oxidation[17]
- triglyceride clearance[17]
- protection from endothelial dysfunction (important facet of atherosclerotic formation)
- insulin sensitivity
- weight loss
- control of energy metabolism.[26]
- upregulation of uncoupling proteins [10]
- reduction of TNF-alpha
Regulation of adiponectin
- Obesity is associated with decreased adiponectin.
- The exact mechanism of regulation is unknown, but adiponectin could be regulated by post-translational mechanisms in cells.[34]
A low level of adiponectin is an independent risk factor for developing:
Lower levels of adiponectin are associated with ADHD in adults.[35]
Adiponectin levels were found to be increased in rheumatoid arthritis patients responding to DMARDs or TNF inhibitor therapy.[36]
Exercise induced release of adiponectin increased hippocampal growth and led to antidepressive symptoms in mice.[37]
As a drug target
Circulating levels of adiponectin can indirectly be increased through lifestyle modifications and certain drugs such as statins.[38]
A small molecule adiponectin receptor AdipoR1 and AdipoR2 agonist, AdipoRon, has been reported.[39]
Extracts of sweet potatoes have been reported to increase levels of adiponectin and thereby improve glycemic control in humans.[40] However, a systematic review concluded there is insufficient evidence to support the consumption of sweet potatoes to treat type 2 diabetes mellitus.[41]
Adiponectin is apparently able to cross the blood-brain-barrier.[42] However, conflicting data on this issue exist.[43] Adiponectin has a half-life of 2.5 hours in humans.[44]
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K (1996). "cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)". Biochem. Biophys. Res. Commun. 221 (2): 286–9. doi:10.1006/bbrc.1996.0587. PMID 8619847.
- ↑ Shapiro L, Scherer PE (1998). "The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor". Curr. Biol. 8 (6): 335–8. doi:10.1016/S0960-9822(98)70133-2. PMID 9512423.
- 1 2 3 4 Díez JJ, Iglesias P (2003). "The role of the novel adipocyte-derived hormone adiponectin in human disease". Eur. J. Endocrinol. 148 (3): 293–300. doi:10.1530/eje.0.1480293. PMID 12611609.
- ↑ Chen J, Tan B, Karteris E, Zervou S, Digby J, Hillhouse EW, Vatish M, Randeva HS (2006). "Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines". Diabetologia. 49 (6): 1292–302. doi:10.1007/s00125-006-0194-7. PMID 16570162.
- 1 2 3 Ukkola O, Santaniemi M (2002). "Adiponectin: a link between excess adiposity and associated comorbidities?". J. Mol. Med. 80 (11): 696–702. doi:10.1007/s00109-002-0378-7. PMID 12436346.
- ↑ Kuo SM, Halpern MM (2011). "Lack of association between body mass index and plasma adiponectin levels in healthy adults". Int J Obes (Lond). 35 (12): 1487–94. doi:10.1038/ijo.2011.20. PMID 21364526.
- ↑ Cawthorn WP, Scheller EL, Learman BS, Parlee SD, Simon BR, Mori H, Ning X, Bree AJ, Schell B, Broome DT, Soliman SS, DelProposto JL, Lumeng CN, Mitra A, Pandit SV, Gallagher KA, Miller JD, Krishnan V, Hui SK, Bredella MA, Fazeli PK, Klibanski A, Horowitz MC, Rosen CJ, MacDougald OA (2014). "Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction". Cell Metab. 20 (2): 368–375. doi:10.1016/j.cmet.2014.06.003. PMID 24998914.
- 1 2 Bauche IB, El Mkadem SA, Pottier AM, Senou M, Many MC, Rezsohazy R, Penicaud L, Maeda N, Funahashi T, Brichard SM (2007). "Overexpression of adiponectin targeted to adipose tissue in transgenic mice: impaired adipocyte differentiation". Endocrinology. 148 (4): 1539–49. doi:10.1210/en.2006-0838. PMID 17204560.
- 1 2 Renaldi O, Pramono B, Sinorita H, Purnomo LB, Asdie RH, Asdie AH (2009). "Hypoadiponectinemia: a risk factor for metabolic syndrome". Acta Med Indones. 41 (1): 20–4. PMID 19258676.
- ↑ Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T (2001). "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity". Nat. Med. 7 (8): 941–6. doi:10.1038/90984. PMID 11479627.
- ↑ Coppola A, Marfella R, Coppola L, Tagliamonte E, Fontana D, Liguori E, Cirillo T, Cafiero M, Natale S, Astarita C (2009). "Effect of weight loss on coronary circulation and adiponectin levels in obese women". Int. J. Cardiol. 134 (3): 414–6. doi:10.1016/j.ijcard.2007.12.087. PMID 18378021.
- ↑ Oh DK, Ciaraldi T, Henry RR Adiponectin in health and disease. Diabetes Obes Metab 2007:9:282–289
- ↑ Zhu N, Pankow JS, Ballantyne CM, Couper D, Hoogeveen RC, Pereira M, Duncan BB, Schmidt MI (2010). "High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC study". J. Clin. Endocrinol. Metab. 95 (11): 5097–104. doi:10.1210/jc.2010-0716. PMC 2968724. PMID 20719834.
- ↑ Rizza S, Gigli F, Galli A, Micchelini B, Lauro D, Lauro R, Federici M (2010). "Adiponectin isoforms in elderly patients with or without coronary artery disease". J Am Geriatr Soc. 58 (4): 702–706. doi:10.1111/j.1532-5415.2010.02773.x. PMID 20398150.
- 1 2 3 4 5 6 7 Nedvídková J, Smitka K, Kopský V, Hainer V (2005). "Adiponectin, an adipocyte-derived protein" (PDF). Physiol Res. 54 (2): 133–40. PMID 15544426.
- ↑ Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. doi:10.1038/nature01705. PMID 12802337.
- ↑ Hug C, Wang J, Ahmad NS, Bogan JS, Tsao TS, Lodish HF (2004). "T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin". Proc. Natl. Acad. Sci. U.S.A. 101 (28): 10308–13. doi:10.1073/pnas.0403382101. PMC 478568. PMID 15210937.
- ↑ Fang X, Sweeney G (2006). "Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes". Biochem. Soc. Trans. 34 (Pt 5): 798–801. doi:10.1042/BST0340798. PMID 17052201.
- ↑ Bonnard C, Durand A, Vidal H, Rieusset J (2008). "Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice". Diabetes Metab. 34 (1): 52–61. doi:10.1016/j.diabet.2007.09.006. PMID 18222103.
- ↑ Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF (Nov 1995). "A novel serum protein similar to C1q, produced exclusively in adipocytes". J Biol Chem. 270 (45): 26746–9. doi:10.1074/jbc.270.45.26746. PMID 7592907.
- 1 2 3 4 Lara-Castro C, Fu Y, Chung BH, Garvey WT (2007). "Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease". Curr. Opin. Lipidol. 18 (3): 263–70. doi:10.1097/MOL.0b013e32814a645f. PMID 17495599.
- ↑ Matsuzawa Y, Funahashi T, Kihara S, Shimomura I (2004). "Adiponectin and metabolic syndrome". Arterioscler. Thromb. Vasc. Biol. 24 (1): 29–33. doi:10.1161/01.ATV.0000099786.99623.EF. PMID 14551151.
- 1 2 Hara K, Yamauchi T, Kadowaki T (2005). "Adiponectin: an adipokine linking adipocytes and type 2 diabetes in humans". Curr. Diab. Rep. 5 (2): 136–40. doi:10.1007/s11892-005-0041-0. PMID 15794918.
- 1 2 3 4 Vasseur F, Leprêtre F, Lacquemant C, Froguel P (2003). "The genetics of adiponectin". Curr. Diab. Rep. 3 (2): 151–8. doi:10.1007/s11892-003-0039-4. PMID 12728641.
- 1 2 Hug C, Lodish HF (2005). "The role of the adipocyte hormone adiponectin in cardiovascular disease". Curr Opin Pharmacol. 5 (2): 129–34. doi:10.1016/j.coph.2005.01.001. PMID 15780820.
- 1 2 Vasseur F, Meyre D, Froguel P (2006). "Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies". Expert Rev Mol Med. 8 (27): 1–12. doi:10.1017/S1462399406000147. PMID 17112391.
- ↑ Choi BH, Kim YH, Ahn IS, Ha JH, Byun JM, Do MS (2009). "The inhibition of inflammatory molecule expression on 3T3-L1 adipocytes by berberine is not mediated by leptin signaling". Nutr Res Pract. 3 (2): 84–8. doi:10.4162/nrp.2009.3.2.84. PMC 2788178. PMID 20016706.
- ↑ Grimshaw CE, Matthews DA, Varughese KI, Skinner M, Xuong NH, Bray T, Hoch J, Whiteley JM (1992). "Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement". J. Biol. Chem. 267 (22): 15334–9. PMID 1639779.
- ↑ Nigro E, Scudiero O, Monaco ML, Palmieri A, Mazzarella G, Costagliola C, Bianco A, Daniele A (2014). "New insight into adiponectin role in obesity and obesity-related diseases". Biomed Res Int. 2014: 658913. doi:10.1155/2014/658913. PMC 4109424. PMID 25110685.
- ↑ Yuan J, Liu W, Liu ZL, Li N (2006). "cDNA cloning, genomic structure, chromosomal mapping and expression analysis of ADIPOQ (adiponectin) in chicken". Cytogenet. Genome Res. 112 (1-2): 148–51. doi:10.1159/000087527. PMID 16276104.
- ↑ Nishio S, Gibert Y, Bernard L, Brunet F, Triqueneaux G, Laudet V (2008). "Adiponectin and adiponectin receptor genes are coexpressed during zebrafish embryogenesis and regulated by food deprivation". Dev. Dyn. 237 (6): 1682–90. doi:10.1002/dvdy.21559. PMID 18489000.
- ↑ Liu M, Liu F (2012). "Up- and down-regulation of adiponectin expression and multimerization: mechanisms and therapeutic implication". Biochimie. 94 (10): 2126–30. doi:10.1016/j.biochi.2012.01.008. PMC 3542391. PMID 22342903.
- ↑ Mavroconstanti T, Halmøy A, Haavik J (2014). "Decreased serum levels of adiponectin in adult attention deficit hyperactivity disorder". Psychiatry Res. 216 (1): 123–30. doi:10.1016/j.psychres.2014.01.025. PMID 24559850.
- ↑ Kim KS, Choi HM, Ji HI, Song R, Yang HI, Lee SK, Yoo MC, Park YB (2014). "Serum adipokine levels in rheumatoid arthritis patients and their contributions to the resistance to treatment". Mol Med Rep. 9 (1): 255–60. doi:10.3892/mmr.2013.1764. PMID 24173909.
- ↑ Yau SY, Li A, Hoo RL, Ching YP, Christie BR, Lee TM, Xu A, So KF (2014). "Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin". Proc. Natl. Acad. Sci. U.S.A. 111 (44): 15810–15815. doi:10.1073/pnas.1415219111. PMC 4226125. PMID 25331877.
- ↑ Lim S, Quon MJ, Koh KK (Apr 2014). "Modulation of adiponectin as a potential therapeutic strategy". Atherosclerosis. 233 (2): 721–8. doi:10.1016/j.atherosclerosis.2014.01.051. PMID 24603219.
- ↑ Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (Nov 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. doi:10.1038/nature12656. PMID 24172895.
- ↑ Ludvik B, Hanefeld M, Pacini G (2008). "Improved metabolic control by Ipomoea batatas (Caiapo) is associated with increased adiponectin and decreased fibrinogen levels in type 2 diabetic subjects". Diabetes Obes Metab. 10 (7): 586–92. doi:10.1111/j.1463-1326.2007.00752.x. PMID 17645559.
- ↑ Ooi CP, Loke SC (2013). "Sweet potato for type 2 diabetes mellitus". Cochrane Database Syst Rev. 9: CD009128. doi:10.1002/14651858.CD009128.pub3. PMID 24000051.
- ↑ Yau SY, Li A, Hoo RL, Ching YP, Christie BR, Lee TM, Xu A, So KF (2014). "Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin". Proc. Natl. Acad. Sci. U.S.A. 111 (44): 15810–5. doi:10.1073/pnas.1415219111. PMC 4226125. PMID 25331877.
- ↑ Spranger J, Verma S, Göhring I, Bobbert T, Seifert J, Sindler AL, Pfeiffer A, Hileman SM, Tschöp M, Banks WA (2006). "Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells". Diabetes. 55 (1): 141–7. doi:10.2337/diabetes.55.1.141. PMID 16380487.
- ↑ Hoffstedt J, Arvidsson E, Sjölin E, Wåhlén K, Arner P (2004). "Adipose tissue adiponectin production and adiponectin serum concentration in human obesity and insulin resistance". J. Clin. Endocrinol. Metab. 89 (3): 1391–6. doi:10.1210/jc.2003-031458. PMID 15001639.


text:
Creating your Own Account Lockout Help Tool
Hi Powershell people …
Powershell is just getting more and more attention each day . I use to do things in vbscript and have not touched vbscript in a long time . That is how much I love powershell . I do not think I'm a Powershell fanboy (but you might think so ) and I don't think being one is a bad thing . I mean its very powerful tool . Now with the announcement of V2 coming in 2009 we as administrators are starting to see things in a different light . Back to the point of this blog I wanted to share a pretty quick and dirty script with you . I mean its quick and dirty because I haven't spent the time to make it production ready although you would not need to change much to make it production . Some of you might think its production ready but I will share with you what I think it needs . Just that I didn't have the time .
We are creating a powershell script to basically parse the netlogon.bak file (because the netlogon.txt file is locked under normal operation ) on a DC . Now there are plenty of tools out there that do something similar . If you use on of those thats fine but I love to try and create my own command line tool . Some tools that you might use is eventcomb from Microsoft . Accountlockout is another gui that will tell you where the account is locked out and what time the lockout occurred . It also lets you unlock the account . Eventcomb is nice in that you can search for different criteria like userid ,Event ID's ,Multiple computers .
So to recap this script will create a results.txt file that will contain all lines in the netlogon.bak file that match the User you pass to the script . For those that are not sure of where the netlogon.bak file is located its in the %windir%\debug folder . This is a GREAT way to find out if the user is being locked out from another machine which is a large percentage of the case mostly . You get these calls from users that don't know that they may have logged onto a Server or PC and that is the cause or possibly a service is running on a Server with their ID running a service . This log file is helpful in solving these problems . This shouldn't be the only tool you use but it will help you in determining the root cause .
Here is the Script :
#Scriptname : Get-AccountLockoutInfo.ps1
#Created by : Chris Federico
#Date : 11/18/2008
param ($logonserver,$userid,$help)
function funHelp()
NAME: Get-AccountLockoutInfo.ps1
Parses the netlogon.bak File for information regarding the account ID that was passed .
-logonserver specifies the logon Server for the User
-userid specifies the userID for the User
-help Prints Help File
.\Get-AccountLockoutInfo.ps1 -logonserver Foo -userid Johnb
queries the Netlogon.bak file on server Foo for userid Johnb and logs entries that are related to lockouts .
.\Get-AccountLockoutInfo.ps1 -help ?
Prints out help file.
function funParse-SecurityLogFile($logonserver,$userid)
#for windows 2000 Systems
$log = gc "\\$logonserver\c$\debug\netlogon.bak" | % { if ($_ -match $userid) {$_ | Out-File ".\results.txt" -Append}}
#For Windows 2008 Systems
$log1 = gc "\\$logonserver\c$\windows\debug\netlogon.bak" | % { if ($_ -match $userid) {$_ | Out-File ".\results.txt" -Append}}
- surpress errors
$ErrorActionPreference = "SilentlyContinue"
#Check to see if help text is requested
if($help) { write-host "Printing help now..." -ForegroundColor Blue;funHelp}
#Check to see if forward and reverse arguments have been entered.
if(!$logonserver) {write-host "You must Supply a logon Server." -ForegroundColor Red ; funHelp}
if(!$userid) {write-host "You must Supply a userid to search" -ForegroundColor Red ; funhelp}
#Create a new Results File.
New-Item -ItemType file -path ".\results.txt" -Force
#Call function that does all the work.
funParse-SecurityLogFile $logonserver $userid
The reason why I think that this script is not primetime production is because I don't include a way to tell if the DC your using is a windows 2000 or 2008 or 2003 . So I made 2 variables log and log1 which use different paths . This is not a show stopper though because I'm suppressing Errors ($ErrorActionPreference = "SilentlyContinue") . If you would like to add a WMI section to find out if the target DC is a windows 2000 or 2003 or 2008 then I think it would be ready . You can probably use s switch statement to perform the appropriate action for example .
switch ($Server)
"Windows 2000" {##Read the log file}
"Windows 2003" {##Read the log file }
"Windows 2008" {##Read the log file }
To to summarize … the results.txt file will have all the lines in the netlogon.bak file that have the UserID you passed into the script . So checkout the netlogon.bak file to see what kind of information it shows .It is really helpful .
Take Care ,
Chris Federico

subset: commoncrawl


text:
I got a bit behind with my weekly online class during my time away, so although our instructor gives us a new word to focus on the beg. of each month along with a tag project I just completed mine this week.
On the left side a napkin was glued to the page and I added my thoughts on indulging. It says "I will indulge by continuing to grow and learn thru books, classes and new experiences that speak to my soul." On the right side I used Distress inks over the page and added a border of dots with a hot pink Sharpie paint pen. I created the tag by stamping the word and painting a floral frame with Twinkling H2Os and drawing on the stitches with a Pitt pen. I have been obsessed with painting these flowers since discovering a wonderful tutorial for this technique. You can find the details and links in this post.
The Summer of Color challenge that was hosted by Kristin earlier this summer for 6 wks. had me so inspired I decided to challenge myself with a few of the color combos that didn't get voted in. I chose a combination that proved to be a challenge but once it started to come together I was glad I did it! The color combo I chose was hot pink and navy.
This is how the journal spread started:
Here is how I completed this page:
The owl shape was cut out from a gelli plate print and the edges were sponged with some Jet Black Staz-On ink. Punched circles from another gelli print for the eyes and embellished with a marker, google eyes and the hot pink paint pen. The beak is a scrap of felt. Next the words were glued in place and outlined with that pink marker. I embellished the page with Nail Jewels pink stars (Dollar Store). I also used a liner brush dipped in white paint to create stars.
Here's the completed spread:
The left page was painted with black gesso before gluing on the Reader's Digest page and words. I added more painted stars and -voila! Are any of you continuing to challenge yourselves since the SOC project? I'd love to know!
I had some nice and exciting surprises regarding my art (small goals I made for myself for this year) recently. I can share one of them now. This came in the mail this week:
Again-no clue as to what project of mine could have been added to this edition but yippee!! One of those small goals I had written down was to have something published in a magazine I'd never been published in before.Check :)
Here's what was published:
This is one of 3 similar pieces I had sent for the "aqua" theme Somerset Studio had going for one of their issues awhile back. I always get the Holidays and Celebrations issue whenever it comes out and have considered submitting specifically for it but just never did. There are always such wonderful projects through out these editions-and speaking of-don't you just LOVE that fabric birdie hanging on the cover??? I'm going to have to make some! This issue is not in the stores yet but should be arriving in the next few weeks. If any of you that visit here are in it please let me know. I haven't taken the time to look through it yet.
Linking up to my favorite places! Looking forward to see what everyone's been up to this week.
" I am always doing that which I cannot do, in order that I may learn how to do it." Pablo Picasso


text:
To say that you need to experience the glory and emotion that is the Pittsburgh Symphony Orchestra's performance of The Sleeping Beauty this weekend is a poor and almost indescribable understatement. Russian and Scottish influences beautifully compete for your senses as the audience is enveloped into the lives and masterpieces of Prokofiev, MacMillan, Tchaikovsky and Rachmaninoff.
My husband, Michael, and I haven't stepped into the great Heinz Hall since last July, where we flew through Hogwarts on an adventure with "The Magical Music of Harry Potter" and the symphony musicians. Since then, a lot has happened. As newlyweds we spent a week in Jamaica, sipping on piña coladas and relaxing on rafts in calm blue-green waters. A few months later, we announced the joyous expansion of our little family and the anticipation of our first child, a son. And, on the 600 block of Penn Avenue in the Cultural District of Pittsburgh, the music stopped. Fast forward to a white and wintry Friday evening in February, and we were both excited to find our seats and settle in to a familiar environment. Secretly I wanted our baby, quickly growing inside me, to hear the enchanting classical foundation that the symphony has become for us.
As the lights dimmed and the orchestra grew quiet after tuning, we watched a brief on-screen introduction into the night's musical menu. I could already feel my belly flutter, and I smiled.
Once we sprinted into Prokofiev's Classical Symphony, I inched ever-so-slightly forward to see conductor Manfred Honeck's eyebrows furl at every progression. Even the soles of his heels seemed animated. After the third of four movements, he exhaled, content and proud. The musicians, dressed in classic black, found their rhythm immediately, whether the notes demanded a subdued isolation or incremental space to grow. Through the music, I imagined young gazelles sprinting through a spring forest at dawn, the entrance of an emperor or presentation of new heritage, even the flight of Tinkerbell in a land of magic and mystery.
Then came Veni, Veni, Emmanuel. I not-so-secretly anticipated this performance for its spiritual undertones, Scottish composition and familiar chorus. Preparing for this piece on stage created quite a noticeable buzz. Nearly 40 different percussion instruments commanded our attention, front and center. Soloist Colin Currie, Maestro Honeck and the orchestra demanded our attention for 30 continuous minutes of one uninterrupted movement, complementing each other through musical tension and a melody so intricate that it almost felt impossibly surreal. I closed my eyes, allowed a wave of visceral emotions to envelop me, and sensed a Russian fairy tale transposed onto Biblical contexts. As the orchestral pupils chimed, lonely, Currie climbed the imaginary Cathedral stairs to end the movement that brought us to our feet and composer Sir James MacMillan to the stage.
After intermission guest concertmaster Alexi Kenney and a full orchestra traveled through Tchaikovsky's The Sleeping Beauty seamlessly and with great emotion. We heard triumphant, short bursts, swift, sweeping melodies, soft lullabies, booming notes and swaying solos. Kenney's artistic execution of the violin as an instrumental extension of his fingers and soul was as breathtaking as it was perfect.
We decided to stay a little longer, and we are so thankful we did. It is obvious that the Pittsburgh Symphony Orchestra loves its patrons and its city. Rachmaninoff's post-concert trio was intimately connected to its audience, performers and progression. I grinned when I realized how romantic and dramatic Russian music can translate through Dimitri's piano chords, Jennifer's string manipulation and Mikhail's energy.
As we left Heinz Hall and headed home, I looked at my husband, thought of our son, and wondered how soon it would be before we were back at this place. I like to think of the Pittsburgh Symphony Orchestra as our musical home, a sanctuary for culture, passion and a shared artistic pulse. I hope and encourage you to find this kind of community here, too.


text:
"I need to recover deleted files from Transcend external hard drive on my computer. Can somebody show me step-by-step guide on how to recover files after deleting from my Transcend external hard drive?"
"I have a 1TB Transcend portable hard drive which contains some videos, photos and office files. Today, I connected my Transcend portable hard drive to my computer and attempted to transfer some data. However, I mistakenly deleted files from the portable hard drive. How can I get back all deleted data from my Transcend portable hard drive?"
"I want to recover deleted videos from my Transcend removable hard drive after quick format. I formatted my Transcend portable HDD because I thought that I have moved all important data to another storage media, but the fact is that I lost some important data after formatting. So I need to recover those deleted files from Transcend portable HDD after formatting."
"Is there any external hard drive data recovery software that can help rescue deleted files after formatting external hard drive? My Transcend USB hard drive was infected with virus, so I formatted it to erase virus. However, all data was deleted due to formatting. Can you tell me how to get back lost files from my Transcend USB hard drive?"
You can recover deleted files from Transcend portable hard drive as long as the original data is not overwritten and the disk is not physically damaged. In order to get back deleted files, you only need to rely on iCare Data Recovery. It is a read-only data recovery utility which enables you to recover all types of files after deleting from your Transcend portable hard drive. iCare Data Recovery is undelete software for Windows platform, so you need to install this software to a Windows PC in order to use it for Transcend external hard drive data recovery.
Preparation: Download and install iCare Data Recovery on your computer. Plug the Transcend external HDD to the computer and run the software.
Step1. Select a proper scan mode after running the software.
Step2. Choose the Transcend external HDD as aim disk and wait the software to scan it.
Step3. Preview found files after scanning and then recover the files you need.
When you delete files on your Transcend USB hard drive, system will erase the data immediately without moving it to recycle bin. However, system does not delete the data permanently. It just erases the file name and entries to the data. System will mark the disk space as empty for new data storage. As long as you do not write new data to the Transcend USB hard drive, you can use iCare Data Recovery for recovery of external hard drive easily.
How to recover files after delete from Transcend removable hard drive? If you are still upset about such kind of problem, you can free download iCare Data Recovery now and follow the guide above to get back lost files after deleting. This data recovery software scans your Transcend removable hard drive and retrieve lost data easily. By using iCare Data Recovery, you can preview found files after scanning so that you can check if they are the files deleted from your Transcend External.
Related Articles
Hard Drive Recovery
Popular on iCare
Hot Trends
Repair raw external hard drive without formatting > Posted by Jan·August 12
How to recover files from corrupted hard drive > Posted by Jean·Feb 15
Formatted external hard drive by mistake >Posted by Mike·August 03


text:
Nice Best Drone Pictures photos
Some cool best drone pictures images: Image from page 790 of "The Journal of the Department of Agriculture, Victoria" (1902) Image by Internet Archive Book Images Identifier: journalofdepartm10vict Title: The Journal of the Department of Agriculture, Victoria Year: 1902 (1900s) Authors: Victoria. Dept. of Agriculture Subjects: Agriculture Agriculture — Australia Victoria Publisher: [Melbourne]: Dept. of Agriculture, Victoria Contributing Library: The LuEsther T Mertz Library, the New York Botanical Garden Digitizing… Read More »


text:
Cool Idea: Light Bulb Candle Holders
The New York Times article "Thinking Like a Student" takes a look at the thrifty, creative home-design moves college students, particularly architecture students, are making during these difficult economic times to make their homes a better place, aesthetically and functionally.
Along with the article is a wonderful slideshow showcasing many of these "on the cheap" tricks. One of my favorites was a set of candle holders fashioned from recycled light bulbs by Lauren Chapman, a student at Yale School of Architecture. By now we've hopefully all made the switch to CFLs, but that doesn't mean we should just toss those standard old bulbs in the trash.
To find out more about this project,
Why not turn them into candle sticks? I've actually shown you lamps made from light bulbs before, but those were much too pricey. My only concern is how Chapman got the bulbs to stand up. I'm thinking that by using a glue gun on the candle holders' bottom, you could create a flat base. Or, you could set a magnet inside the bulb, and then one underneath your table cloth, like those DIY magnetic vases. What do you think? Do you like it, or is it too thrifty-looking for you?
Photo by Phil Mansfield for The New York Times


text:
A YouTube video showing a supposed social experiment with a very public toilet is exposing the dangers about a new U.K. telecommunications bill that critics believe will infringe upon the right to privacy.
The video, which was uploaded by the nonprofit Open Rights Group, depicts people on a busy London street entering a public bathroom. When each person closes the bathroom's door, the walls become transparent. Everyone on the street around them can clearly see inside.
"We're sorry, but you'll have to get used to your privacy being exposed," a disembodied voice tells the bathrooms' shocked occupants.
The video was created to demonstrate how the United Kingdom's new Investigatory Powers Bill, also known as Snooper's Charter, would give law enforcement more powers that could compromise everyone's privacy.
"The video was entirely unscripted," Jim Killock, executive director of the Open Rights Group, wrote to A Plus. "We wanted to get spontaneous reaction to the threat of exposing people's privacy."
The bill allows the U.K. government to collect any citizen's records of Internet history and phone metadata. It also gives law enforcement the power to hack people's electronic devices.
Proponents of the law say that these provisions are needed to improve security, and cite past operations by intelligence agencies MI6 and GCHQ, as well as the National Crime Agency, as evidence.
"Without access to communications data, the National Crime Agency would not have had the evidence to prosecute pedophiles who had been visiting websites with indecent images of children," British politician Suella Fernandes wrote to The Telegraph. "Without interception intelligence, MI6 could not have detected and disrupted numerous plots to attack the UK being planned by individuals based abroad. And without access to bulk data, GCHQ would not be able to uncover cyber-attacks against the UK."
Critics, like NSA whistleblower Edward Snowden, say the bill is a major invasion of privacy.
On Tuesday, the U.K. House of Commons passed the controversial bill. A recent poll found that 72 percent of citizens knew nothing about it. Hopefully, this video campaign from the Open Rights Group will educate the public about this important law.
"Public reaction [to the video] has been fantastic," Killock wrote to A Plus. "It has brought the issue of surveillance and privacy to a very new audience, and has been shared globally, as well as in the U.K."


text:
Happy to see resource blocking got slashdotted. Still far away from our default-deny vision @ W2SP, let alone what Ben wrote about with mutation event transforms and followed up on in our Oakland paper, but having the spotlight there helps force the issue.
Been in heads-down mode all summer experimenting on a new high-performance computing inspired language runtime; hopefully be able to say something interesting about that soon. Next few weeks should be fun: ~2 weeks in RI (+MA/NY?), a few days in the Maryland/DC area, a few more in Seattle+Redmond, and finally either Vancouver (CA) or Costa Rica. Assuming some experiments turn out well this week, that means I should have some downtime to hack on the language prediction stuff again!


text:
Tuesday, February 05, 2008
Spot The Difference...
It's always a pleasure to find a statue of a fellow balding man! Not quite sure who this chap was sadly, but he was stationed in the Vatican Museums, along with, quite literally, thousands of other statues and monuments. We stood by a fair few of them, so expect to see them on the site soon (ish). This isn't the only statue look-alike of yours truly either, I'm happy to report.
No comments:
Subscribe to: Post Comments (Atom)


text:
As the name suggests, Revitalizer was designed to provide an energy boost when you need it most. This blend of vitamins and nutrients, including thiamin, niacin, vitamins B6, B12, A, and E, are delivered to your body with optimal potency.
The B vitamins are essential to energy production, and since all but B12 are unable to be stored in your body, supplementation is the best way to ensure that you have the right amounts. With an extra boost from vitamins A and E.
You can say no to:
- Caffeine
- Energy drinks
- Sugary food and drink
We have a perfectly formulated product with Cystine, Thiamine, and B6 all to help alleviate the symptoms of that green hangover you may end up getting, as well as several B vitamins to help keep your energy levels throughout the night.
On top of the true energy production of Revitalizer, it also freshens your breath.
Supplement Facts
Serving Size 8 Sprays (0.4 ml)
Servings Per Container 30