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Implementing a Novel Genetic Engineering Technique in Lab Protocols
A new genetic engineering technique allows scientists to specify a particular level of gene expression in cells, which could lead to key insights about complex disease mechanisms. Image Credit: Flickr user FotoMediamatic
Researchers at Washington University in St. Louis have developed a novel genetic engineering technique that allows scientists to control exactly how much protein is produced from a particular gene. In January 2017, they published a paper in Nature Communications describing a method for generating hypomorphic mutations—that is, mutations that lead to a reduction in the amount of gene product.1
The authors have proposed a variety of scientific applications for this new method. For instance, it could be used to genetically engineer crops that are able to grow with less water. It could also be employed by biologics manufacturers who are trying to optimize product production.2 But perhaps the most immediate application is in disease research. This method can enable researchers to more closely evaluate the effects of particular genes on disease processes than they have in the past. As biomedical scientists start using this method to support their research, they can benefit from workflow authoring and execution software.
Research Advantages of the New Genetic Engineering Method
In the hypomorphic mutation engineering method described by the Washington University researchers, strings of consecutive adenosine nucleotides, also known as polyA tracks, are introduced into mRNA in order to lower the overall translation efficiency. PolyA tracks are cis regulatory elements that cause ribosomal stalling and frameshifts, so inserting them into the open reading frame leads to mRNA instability and the production of peptide chains that are targeted for degradation. As a result, less of the expected protein is produced.3
In complex diseases, like cancer and autism, scientists know that certain genes are downregulated, but they do not understand how that contributes specifically to the disease etiology. This method provides several key advantages for scientists who are studying complicated disease mechanisms:
- Increasing the speed of research
Traditionally, hypomorphic mutations have been generated through chemical mutagenesis screens. However, creating a mutation that leads to the production of a specific amount of gene product requires extensive experimentation. Scientists need to isolate, identify and characterize the allele before they even begin to start creating genetic analysis procedures. That means it could be years before they start getting results. According to the Washington University researchers, their method could cut the process time to a matter of days.
- Making it possible to study more genes
Another way that scientists have previously used to study downregulated genes is to knock out out one or both copies of the gene. However, standard gene knockouts are not always able to accurately replicate what actually happens in the cell. For instance, if both copies of the gene are knocked out, it is often lethal, so scientists cannot study the downstream or long-term effects. On the other hand, if only one copy is knocked out, there may be no effects, since one copy may be sufficient for normal function. With a more easily controlled hypomorphic mutation engineering method, scientists can reproduce the exact amount of gene that is produced in the disease state, or any other amount that they desire. This may make it possible to gain insight into the roles of genes that have previously been difficult to study due to lethality and haplosufficiency issues.
- Applications to multiple species
The new method for generating hypomorphic mutations also stands out because it is applicable to multiple species. When running a chemical mutagenesis screen or preparing a knockout protocol, the method is usually unique to a single organism. However, because the mRNA translation machinery varies only minimally between organisms, adding polyA tracks can work in lots of model organisms, as well as in cell culture. Indeed, the researchers at Washington University in St. Louis demonstrated that their method works in bacteria, yeast, protozoans, Drosophila, mice, plant tissue and human tissue culture, so it is clearly applicable in almost any kind of disease research lab.
Integration Into Lab Procedures
Disease research labs that plan to start using this new genetic engineering technique for their work can benefit from workflow authoring tools that standardize the creation of procedures. This can be especially helpful for widely applicable techniques, like the creation of hypomorphic mutations through polyA track insertion, because the same general technique can be reused and tweaked in multiple protocols. For instance, a standard method can be altered slightly for experiments on different genes or in different organisms, without having to rewrite the entire protocol from scratch.
These protocols can also be supported by method execution applications, which provide an easy-to-follow interface for scientists who are conducting the experiments. Since hypomorphic mutation creation procedures are likely to be similar—but not exactly the same—for experiments on various genes and diseases, this software makes it easier to avoid overlooking project-specific methodological changes or accidentally skipping a step when implementing a new protocol. Plus, the procedural information is accessible from mobile devices, so researchers will have constant access to their notes as they walk around the lab.
BIOVIA Compose is a workflow authoring software application for standardized procedure creation, and it is supported by BIOVIA Capture, a standardized method execution application that is compatible with mobile devices like tablets. Contact us today to learn more about how these technologies can improve research efficiency in your lab when implementing new techniques like the recently-described genetic engineering method for hypomorphic mutation creation.
- "Hypomorphic mutation," April 4, 2017, http://www.informatics.jax.org/glossary/hypomorphic ↩
- "New genetic engineering technique could help design, study biological systems," January 20, 2017, https://medicine.wustl.edu/news/new-genetic-engineering-technique-help-design-study-biological-systems/ ↩
- "Rapid generation of hypomorphic mutations," January 20, 2017, https://www.nature.com/articles/ncomms14112 ↩


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Two Census Research Cruises Currently At Sea
Departing June 8, 2009, MAR-ECO researchers aboard the NOAA Fisheries vessel Henry B. Bigelow steamed for the North Atlantic to study the Charlie Gibbs Fracture Zone along the Mid-Atlantic Ridge. The aim of the cruise is to further study the deep-water ecosystems associated with under-explored area. A cruise blog can be viewed on the Virginia Institute of Marine Science website and a full article highlighting the details of the cruise is also available. For more information visit: MAR-ECO.
A second cruise departed Wellington New Zealand on June 12, 2009 with the R/V Tangaroa once again carrying CenSeam researchers to the Graveyard seamounts on the Chatham Rise in the South Pacific. This cruise aims to study the biodiversity of the region and to continue research initiated on earlier cruises. Full details of the cruise and a ship-to-shore log can be found on the CenSeam website: Return to the Graveyard.

subset: commoncrawl


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Hi guys!
I have always loved reading, but did not read as much as I want. Fortunately, when I bought an e-ink reader and started getting to work by the metro, I got at least one hour of reading every day! It looks not so much, but for the last three years I read more books than for the previous decade.
I like books of different genres. For example, my previous passion was for dystopian novels like Fahrenheit 451 by Ray Bradbury or Nineteen Eighty-Four by George Orwell. Before it I was interested in books about our universe like The Fabric of the Cosmos by Brian Greene, some psychology books like The Willpower Instinct by Kelly McGonigal, and so on.
Today I would like to share with you a book that influenced me most and I think changed my life in some way. This is Soft Skills: The software developer's life manual by John Sonmez. It is a bit strange book for software developers that tells nothing about software. However, it gives a lot of priceless advice how to become a great developer, successful investor, and even a body-builder. 🙂
The author describes his way from a nerd to a rockstar-like developer, a successful real estate investor and a body-builder. It is not an one-moment change, but a constant work on improving yourself in different areas. John shares his knowledge in a form of simple advice and to-do actions. The author style is clean and easy to read and understand.
There are the following topics in the book:
- Career, marketing yourself
- Learning
- Productivity
- Finances
- Fitness
- Spirit
For me I found the most useful topics related to career that includes marketing yourself and productivity as the essential parts. If you are like me, then you probably experienced troubles in your career when it is not clear what to do to get a promotion. John gives a clear answer. Probably the answer is familiar to you (as it was for me), but he also gives concrete steps how to reach all the goals and why it is important.
To be successful you need to have goals in your life and be able to prioritize them. Then you should learn how to learn effectively. To reach the goals you should be productive and do not waste your time. A crucial part of success is marketing yourself. Without marketing, most likely, you won't reach much. Without deliberate financial approach you won't be able to become financially independent. You will be much happier if you are healthy, so you should stay in fit. And, of course, your spirit is the crucial part. Where one sees flaws, the other sees possibilities. Look for a way to give your friends, colleagues, other people as much value as possible and it will return to you multiplied.
I tried to apply in life some advice from the book and it works greatly! I hope it will also work for you.


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Looking for guy for fun freindship & more
14th February 2015 - 18:57 | Cambridge UK, Peterborough | Age 42
I am looking for friendship and fun with a younger guy 18-35 bi or gay. Could be possible relationship if we click. I am just a normal guy who is attracted to younger guys. If you are looking for an older guy for security and friendship reply with your picture. You will get mine back in return.
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Back of Box
Duel it out with five new speed machines for Test Drive II!
The Supercars. Five elite automobiles from around the world that speak one common language--performance. Now, with The Duel: Test Drive II, you can race them in head-to-head competition.
'88 Lotus Turbo Esprit--If you're expecting typical British reserve, guess again. This Esprit is as sensuous and aggressive as any exotic to come out of Italy. And any car capable of pegging its 160 mph speedometer is certainly worthy of Supercar status. The Lotus handling is world famous. The 2.2-liter turbocharged engine, irresistible. Keep a stiff upper lip and let Esprit's 228 horses stampede.
Ferrari Testarossa--A legend in its own time. The elite of Grand Touring cars. This Ferrari hits 185 mph with twelve cylinders singing in perfect harmony. 0-60 mph strikes in 5.3 seconds and the quarter mile blurs by at 13.3--well over 100 mph. But speed isn't the only thing to snap necks. Take one look at its styling, its wrap around leather interior--and you'll know exactly what you'd do with $134,000.
Porsche 911 RUF--Introducing Louis Ruf's gift to the automotive world--a custom built, twin-turbo Porsche 911. Top speed: 211 mph. 0-60 mph: 4.0 seconds. Blindingly quick. Acceleration that sucks you into the seat. Supreme ruler of the German Autobahn, this 469 bhp bullet is perfectly street legal. But don't let that fool you. The space program would provide better preparation for this experience than driving school.
'88 Lamborghini Countach 5000S--Stunning. No other word best describes the Lamborghini's look--or performance. How can a car so outrageous be so darn fast? Take a look under the hood. The Countach sports a powerful V-12 with four valves per cylinder. Before you can say "Giotto Bizzarrini" you're at 179 mph. And nothing can match its stability at top speed. Go out on the open road. Count how many times "WOW" leaves your mouth.
'89 Corvette ZR1--Tough to keep a 185 mph Corvette under wraps but the ZR1 stands as one of Detroit's best kept secrets. Designed with one goal: "create the world's fastest production car." It's engine, code named LT5, is a legend before its time. An all-aluminum, four cam, 32 valve V-8 so strong that Chevrolet engineers has to completely redo the rear end to accommodate more rubber. Is there anything similar to the ZR1? Check out the Indy 500.


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Friday, April 26, 2013
About 2:32 this AM I awoke with the startling realization of why a Zombie Apocalypse could never occur; THE LAWS OF THERMODYNAMICS, THE LAWS OF THERMODYNAMICS, THE LAWS OF THERMODYNAMICS!!!!! I screamed at the top of my lungs and instantaneously received a kick from my wife Bruce Lee would be proud of, startled my sleeping dogs into a barking frenzy and immediately fell back to sleep hoping this true Eureka! moment would still be with me upon my awakening.
Fortunately, it stayed with me and now I must relate to all why a Zombie apocalypse (do I really need to capitalize Zombie, dunno, but I'll continue out of respect for the Zombies of course) can never occur due to strict violations of the laws of thermodynamics. What this also means is that if a Zombie apocalypse does ever occur we must find and eliminate the energy source behind it, before it's too late for us all. Due to the unerring laws of thermodynamics the only way a Zombie apocalypse could occur is if we humans (or is it 'us humans' whatever, I'm not being graded) or possible extraterrestrial beings, supply an outside energy source to fuel the Zombie resurrection. OK, so let's look at each of the laws of thermodynamics and analyze why they will save us from a Zombie demise;
The first law of thermodynamics states that 'the total energy of a system and its surroundings is constant.' (Biochemistry, 7th Edition, Berg et. al.) Or said another way, energy is neither created nor destroyed, it just changes forms. Ah ha you say! That's it! There can be a Zombie uprising because it's just the energy changing forms part that allows Zombies to resurrect.
Not so fast. We need to analyze this law a bit further. The first thing we need to calculate is the total amount of people who have died. This is difficult because we can only do this within recorded history. So, using what we know from recorded history 99,000,000,000, that's 99 billion people have died throughout the known recorded history of the world. That number is going to be higher, much higher. Right now an interesting thought just occurred to me "In a Zombie apocalypse, is it just humans in the Homo sapiens species which will become a Zombie? What about H. floresiensis, H. neanderthalensis, H. rhodesiensis, H. heidelbergensis, H. paleohungaricus, or H. erectus (my personal favorite) all the way back to H. australopithecus?" (BTW, I left about 8 or so genuses out, but I think you get my point) Oh yeah, that part of the discussion only applies if you, ummmm, 'believe' in evolution.
Anyway, will other primates become Zombies as well; you know like gorillas, monkeys, chimps etc. What about other animals? Since we never see anything other than human Zombies I guess we can assume the term Zombie only applies to those of the Homo sapiens variety.
Getting back to why a Zombie apocalypse violates the first law of thermodynamics and using the more formal definition of the law, that is, 'the total energy of a system and its surroundings is constant', it would take a large amount of energy to awaken, in a Zombie sense, those 99 billion people. That's a tremendous energy input. Where's this energy coming from? Is it from other parts of our galaxy, our universe? Is it energy which traveled through a wormhole perhaps (right now I'd love to have a hot line to Stephen Hawkings)? And that's just to get the 99 billion known dead into a Zombie transition.
I know, I know, now you're thinking that Dr. Jim is a fool. Everyone knows it's a virus that is causing the Zombies to rise and that's where the extra energy is coming from. The problem with this line of reasoning is that viruses are neither alive or dead, they are either activated or inactivated. Viruses must rely on living cells to become activated. But we all know Zombies are already dead (really referred to as the living dead, but that's not an oxymoron I am about to tackle here, right now I'm battling the laws of thermodynamics), so the cells are dead, ergo these cells cannot activate viruses. So forget the virus theory contributing to the Zombie apocalypse.
So again I ask; where is all the energy coming from to allow the Zombies to become Zombies. Heck, we all know they can walk, appear to move all intact extremities and can easily eat brains (and apparently digest them, I guess) when presented to them. Getting back to the intact extremities; another first law thermodynamic problem is that when a Zombie limb is severed (and even a head), the extremity still moves or the head still moves etc. Is the energy allowing this motion related to the initial intact Zombie or is it fueled separately from the same source that originally fueled the Zombie in the first place. This brings up a whole new set of problems with our first law, but the question is the same; if energy is neither created nor destroyed, if the energy of a system and it's surroundings is constant, where is all this extra energy coming from to create, cause, allow etc the Zombie apocalypse? As a side note, do Zombies digest? They never show a Zombie urinating or using the bathroom for that matter, so like how is the stuff they eat, ummmm, digested? Is it digested? Does it just sit in the Zombie belly and cause bloating? But a Zombie's already dead so is it safe to assume that the esophagus, stomach, intestines and all digestive organs & enzymes are dead too, or are they still working? And why the craving for brains? Anyone who understands the correct way to eat will immediately have the answer to that, 'Zombies eat brains because brains are mainly fat and Zombies obviously instinctively know the correct way to eat.' Bottom line; Zombies are following a low carb diet and they know more about the correct way to eat than most physicians, nutritionists and dietitians! (Sorry, I just couldn't resist)
So the take home message as to why a Zombie apocalypse violates the first law of thermodynamics is; Because there is a constant amount of energy in our universe and that energy is neither created nor destroyed and since one cannot create energy out of a vacuum (forget the whole Big Bang thing for now, it just muddies my hypothesis); to have a Zombie apocalypse would require more energy than is currently available in our universe! Can't happen, no way, no how! Phew! OK, on to the second law;
The second law of thermodynamics states; 'the total entropy of a system plus that of its surroundings always increases.' (same reference as above) The second law deals with a concept known as entropy or the fact that our universe favors towards disorder. An easy way to visualize this is if you have a child, go clean their room, don't clean up after them for a month; then check their room. The result; entropy!
The second law deals a lot with heat exchanges as well, referred to as enthalpy, but I wont touch upon that here, all we need to remember is that systems tend toward disorder, not order. In a Zombie apocalypse to rise from the dead would require the creation of some type of, say, order. I don't want to use the term heat because I do not know the temperature of a Zombie. I'm assuming they'd be at room temperature (which, as an aside, raises an interesting question; could a Zombie exist without proper attire in Antarctica or the South Pole? Wouldn't they just freeze? Assuming I'm wrong about this thermodynamic stuff and a Zombie apocalypse actually happens, shouldn't we all just move to a much colder climate? After all, all the Zombies I've ever seen were in warm environments, OK, back to our discussion).
So to have a Zombie Apocalypse would require the creation of more order in our universe, much more order (remember the 99 billion plus number); since this goes against the second law of thermodynamics and directly violates entropy (think of a room cleaning itself by itself with no outside influence, just cannot happen) a Zombie apocalypse is impossible. Phew! That made sense. Now on to the third law;
The third law of thermodynamics states that 'the entropy of a perfect crystal at absolute zero is exactly equal to zero.' (This definition I just remember from chemistry so I'm the reference.) This is an easy law of thermodynamics to apply to Zombies because IT HAS NOTHING TO DO WITH ZOMBIES BECAUSE THEY WONT BE ABLE TO MOVE BECAUSE THEY'LL BE FROZEN!!!!!! Duh! They'll be at zero degrees Kelvin or something like that...
In conclusion; from my erudite discussion above one can conclude that a Zombie Apocalypse cannot occur as it will be in violation of all three laws of thermodynamics.
Caveat; in the event I'm wrong, someone, or more frighteningly, something, will be supplying the energy necessary to create the energy needed to increase order to allow the Zombies to come after us. We'll need to find that energy source and destroy it. Barring that, buy yourself a Northface or Patagonia or just a really warm coat and get to the nearest, most coldest climate and good luck!
Have a great weekend all!
dr jim
Author: GENOCIDE: HOW ZOMBIES KNOW MORE ABOUT NUTRITION THAN YOUR DOCTOR
4 comments:
Hi Dr Jim,ReplyDelete
I don't think you read my comment in the last post you wrote when I said I couldn't paste my letter to you, must be a word limit here. You had said in a post some time ago that you'd get your email working - you'd forgotten your password LOL Have you got a working email now ?
Strange that your old practice didn't forward my letter to you - I wrote it to a Port Jefferson address. I'm from the UK btw !
Hi there,ReplyDelete
Nope, didn't get to it yet. The old e-mail was shut down. Kindly send to firstname.lastname@example.com. And don't worry, I still intend on answering your ketosis question, just got side tracked by thermodynamics and Zombies :-)
Thanks Dr Jim ! Email is on it's way to you ! It wasn't me that asked about ketosis - no worries. I'm on very low carb, around 30g per day, so I'm probably in ketosis and have no worries about it, don't check for it, but feel well. I'm a thin atypical Type 2 diabetic who is not insulin resistant but rather insulin deficient...low carb is the way to go !ReplyDelete
Just had to google the thermodynamics of the walking dead. Even if they had particularly efficient metabolisms, and were surviving off of what they had stored (quite a lot in atlanta, probably) and what they ate (are they clearing out the deer and rabbits?) there is also the problem of the fact that every character seems to have killed 100 zombies. After these months of the zombies, how are there still so many zombies! Please, write up the numbers. I want to know (but I'm lazy).ReplyDelete


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Christening Entertainment Blackburn
Christening DJ Blackburn
Greetings everyone, and this is my Christening Entertainment Blackburn page! I cover the WHOLE of Blackburn with Darwen including; Eccleshill. Livesey. North Turton. Pleasington. Tockholes. Openshaw. Wilpshire. Clitheroe, and Accrington.
I've got a handful of function types I concentrate on and make certain I shine and offer something different from all the other DJ's/Entertainers in Blackburn. Christenings are one of those function types where there is a huge hole in the market out there. Plenty of DJ's just see a Christening as easy money, blast quite a few favourite songs at you in order to get people dancing (rarely works) and go back home afterwards. That's all good, but during the last few years people don't always feel the need to get a DJ for a christening any more.
Christening DJ Blackburn
I am striving to help change all of that. My Christening socials are often lots of fun for the whole family and are not boring in the slightest. I come PREPARED with plenty of expertise throughout the day ahead.
I carry my own sound system and several Disco lighting effects and fill the job of a typical Christening DJ Blackburn, which I play music through the celebration at an reasonable level and not too over the top both for children and adults alike.
Christening Entertainment Blackburn
My view of a typical Christening party in Blackburn and surrounding areas:
Children and adults arrive at the venue; I've already filled the dance floor with balloons to give the initial arriver's children something to do; they either play with the balloons independently, together with other little ones or fling them at parents or me. I encourage them to throw them and play catch with me as it builds a rapport for further on in the event.
Usually I'll try to play a musical game with them. I.e., Musical Bumps and after that we'll enjoy a break for buffet (around an hour into your event)
After the buffet, I can bring them all towards the front for introductions where they are going to learn my name as well as the other children's names that attend. Sometimes quite often brushed past, but is definitely a essential element of growing up and quite a few of the children will see each other again at other events and it's nice to know their names for future.
Following the social interaction, we move into an activity of Giant Twister. Attempting to explain the rules is hard enough and them using the game is even more amusing. Always a barrel of laughs and keeps your kids occupied.
After we have everybody out and given sweets to runners up and bubbles for the winners, we'll start some dancing. I'm an excellent Dad Dancer and help them learn all of the moves to many favourite songs including Macarena. YMCA. Music Man. Hokey Cokey and many more. For the first song, I'm going to have the children to bring up a mother or father and then, the parents are excused if they wish to be.
Determined by age group, I'm going to usually play a ball and hoop game, just as straightforward as throw a ball through a hoop but everyone from age 3 up normally takes part and it also keeps them engaged with competitive games that get more difficult because the levels increase.
Then another musical game – Musical Statues. This is always funny because the children keep in mind the rules for musical bumps and several continue playing that game even though we have changed over.
Other games I will play based upon times: Limbo, Team games, Space Hopper Races (following the red tape risk assessments and parental consents, Safe practices gone mad), similar to a Sack Race, Hoola games, and disc onto target games.
When the event is ending, about 1 hour before, I sit them all down somewhere within sight of parents and provide the colouring pads and crayons. I have got all of the favourites like, Hello Kitty. Peppa Pig. Buzz Lightyear. Iggle Piggle. Thomas the Tank Engine. Harry Potter and many others.
Don't leave it too late, call me now to book your Christening Entertainment Blackburn and it will certainly be a pleasure for me to be your Christening Entertainer Blackburn. Call today to have your date inside my diary.


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Massachusetts Residency Rules
How to get in-state at Universities in Massachusetts:
Although you can be in school during your one-year domicile period, there are strict financial requirements many will find difficult to abide by. The major requirement at universities in Massachusetts is no financial support is allowed from parents whatsoever or you're disqualified. Infinite emotional, psychological, and moral support still possible of course. Non-parent support however, is allowed. If this is worth further considering then please see below links to available in-state overviews for universities in Massachusetts because every university in the state has its own unique policies and interpretations of state law.
Massachusetts Reciprocity Agreements:
Massachusetts is a member state of the Regional Student Program which is a limited regional reciprocity agreement among select Northeastern States. Favorable college tuition rates in nearby states are sometimes possible through reciprocity although many restrictions apply.
See Tuition Reciprocity Agreements Explained
See Tuition Reciprocity Agreements Overpromise & Under-Deliver
University-Specific Overviews Below:
Below please find links to in-state overviews for select universities in Massachusetts. If your college is not highlighted, then please consider buying a University-Specific Nutshell Report or see all available university-specific in-state overviews.
Popular Universities in Massachusetts:
University of Massachusetts-Amherst
Other Universities in Massachusetts:
Bridgewater State University-Bridgewater
Fitchburg State College-Fitchburg
Framingham State College-Framingham
Massachusetts College of Art and Design-Boston
Massachusetts College of Liberal Arts-North Adams
Massachusetts Maritime Academy-Buzzards Bay
Salem State University-Salem
University of Massachusetts Medical School-Worcester
University of Massachusetts-Boston
University of Massachusetts-Dartmouth
University of Massachusetts-Lowell
Westfield State University-Westfield
Worcester State University-Worcester
Every College in Massachusetts Is Unique
Just as every state has its own in-state regulations, each college in the state has its own interpretations. Learn everything important about how to actually earn in-state tuition at the university in Massachusetts you're most interested in.


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Tomorrow (Thursday 21st April) Steve Patterson the folklorist and writer, will lead a walking group around Rocky Valley, St Nectans Glen and Kieve.
It will be a great way of seeing some unique geological sites, and an opportunity to learn about the rich folklore and history of the area.
Rocky Valley from the coast path, looking towards Boscastle
Inland at Rocky Valley, near the site of the famous labyrinth
St Nectans Kieve
Tickets are £7.50 - and it is not too late to book your place - give the Museum a call on 01840 250 111, or email email@example.com
The walk will begin at 13.30 at Boscastle car park (car share to St. Nectans) otherwise walkers are invited to go straight to the St. Nectan car park for 13.45. The walk will last approximately 4 hours and stout walking boots are recommended.
Free entry to the Museum of Witchcraft and Magic AND St. Nectan's Glen is included in the price!


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Since writing the blog post below I thought I would share some more of the gluten-free, dairy-free and egg-free cakes I have made over the years! Both kids get a cake that is gluten-free these days to that nobody is left out! Before coeliac disease was diagnosed, dairy and eggs had to be avoided so some of these cakes are dairy and egg-free! I am becoming quite an expert!!!
|The first one! Definately dairy and egg free!
|A selection to take to a party and share!
|Number 2- obviously!
|My first foray into cake pops! They went down well!!!
|My second attempt at cake pops!
|Birthday cake to go to nursery to be shared!
|Toffee apple cupcakes…just for a treat!
|You've seen this elsewhere on my blog…cake for year 5!
|…and my son's this year!
|More cakes ready for sharing at a party…carrot cake cupcakes…dairy and gluten free
|Sorry hubby…giving your age away!!! Of course it was gluten free too!!


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Do you want to have a website that is attractive and inviting for visitors? Then this article is for you. You can learn what it takes to start, or some insightful information about website development in general from the advice in this article. Whether you consider yourself a true beginner or a real pro, you will gain a lot by reading this article.
Make sure your website passes a test by NoScript. Firefox has a simple extension called NoScript that will perform the test. Some stuff won't work unless there are scripts.
Frame designs were great in the 1990s, but they are no longer useful. The fact is that while frames were popular in the past, they were simply one of many early techniques that were necessary then but are not today. They are the stone wheel of the Internet generation and should not be used today. A website that uses frames can cause trouble for visitors when they try to bookmark a site, and no one wants to spend their time scrolling on a website needlessly. You can make something that is easier for users to use.
Remember, frames are a thing of the past and while revisiting past memories can be fun, adding outdated frames will only make your designs appear to be zombies from the world wide web graveyard. Frames were popular on web pages back then but they created numerous problems. Frames make it hard for visitors to bookmark and scroll through the page. There are many better alternatives to frames.
You want to have a site that is easy to navigate, if you want to attract visitors. You should have links that are easy to find, as well as displayed well. A navigation menu will also help visitors locate exactly what they're looking for. To enable easy browsing, be sure that each page includes a link back to the home page.
Regardless of your target audience or what type of site you have, try to keep your loading time under ten seconds. A great website should pop up without lagging delays. If the site takes too long to load, you run the risk of losing your audience.
Use a sensible background for your site. Some sites have moving GIF backgrounds, which can be great at times, but can make your text difficult to read at other times. Chose a background that complements your website's content, rather than a background that clashes with your website's content. Your website's visitors will then find it easier to read your website's content.
Have a simple front page. Those who are shopping the web will make snap decisions about a site based off its front page. make your business description specific and provide unique offerings, just keep distraction to a minimum.
Despite the type of site you are going to have, you definitely want to keep the loading time under ten seconds. You want your site to load quickly on the browser of whoever is visiting your page. Most online users crave instant gratification, so your success relies on providing it.
Add pictures to your site to make it look better This makes your site more user-friendly. People will take more time browsing your site and looking at pictures.
Avoid the overuse of different fonts when you are designing your website. Also consider how the fonts look on a regular screen. Small serif fonts are harder to read. The majority of sites utilize Verdana, which is easy to read in any size or color.
It is important to have content on your site that is not only interesting, but compelling as well. Good content is really more important than flashy design. If you have insightful, useful content that people want to read about, you are much more likely to have repeat visitors.
Use Photoshop to create professional looking graphics for use on your website. By using this type of program, a novice designer will be able to make high quality looking websites at a fast pace. Although a copy of Photoshop represents a significant investment, the time it will save you and the improvement it will make in your results can easily justify the program's cost.
When you have more than one website idea, reserve the domain names at the same time. Be creative and pick out something that you want, but make sure you reserve it now so that you can still have it later on down the road. It is not uncommon for many people to have similar ideas. We are all stimulated by the same media and social events.
Alt Tags
Everyone has heard about Photoshop, and they know that they have to learn it in order to become successful with web design. Many people are not familiarized with Dreamweaver software, so research this program to see what it can offer you and your website design.
As you go about setting up your website, make sure that you add ALT tags to all images on the site. These tags are used to describe the images they accompany in case the image is not displayed, such as when a user disables graphics or is visually impaired and uses transcription software to translate images and read them aloud. No mater whether you use image links or not, the use of an ALT tag gives a better explanation. Finally, search engine crawlers like ALT tags as they are useful. So, your search rank might improve as a result.
Take a poll of your target audience before you begin designing your website, so you know what they would be interested in seeing on your site. This will assist with the overall design of your website in a positive way. The advice you glean from your target market will prove to be invaluable.
Do your best to optimize the loading times on every page of your website. Visitors will leave if they find themselves waiting for your website to load. Reduce file sizes, graphics and fancy coding to bring your pages down to acceptable load times.
Remember, designing your site needs not to cost a lot of money. For each pricy, popular, useful web design tool, there exists one of equal usefulness that costs less. For instance, there is no cost open source software that can assist you in many of the sames ways as paid software. Using these free tools can save you a stack of cash!
Keep your content brief, especially if you are new to web design. You don't want to add a bunch of stuff that is going to fluster you because this can make your visitors confused as well when they come visit your site.
Always consider the literacy levels of your audience when creating new content for your website. Some people may have very basic reading skills, while others may be quite advanced. Your content is useless to your visitors if they can't understand it.
Use a basic layout that will help you build a website design foundation on which to build. This basic design will help you grasp the easy stuff, which will prepare you to tackle more advanced website creation principles in time.
If you need to design more than one website, then you should check into multiple platforms. Learning Java, MySQL, PHP and other platforms is going to help you for years to come. Whether you're a hobbyist designer or a grizzled professional, knowing a lot of different web technologies is sure to make you more in-demand.
Talk to a pro and ask their advice; you will learn a great deal from a master of website development, because they already know how to create well-designed sites. You'll rapidly advance your knowledge of design this way.
If you put videos on your site, make sure to optimize them so that people with slower connections can view them. A video that is converted to 5,000 kb/s will load faster on some computers, but it might be faster than some Internet connections allow for. Videos with extremely high speeds like this will load slowly and buffer frequently for visitors on slow connections.
If you happen to be working with FileZilla, then take advantage of built-in features such as quick menus that immediately pull up your username, port, domain and even passwords. That way, you only need to select your settings from the personalized menu whenever you need to log back into the server. This will save you time and money!
If you are going to be a website designer, unleash your inner artist. Take inspiration from all areas of your life, and allow it to shine through in your work. Take notes anytime or anywhere you might have an idea to bring to life. If something occurs while you're working, leave yourself a text message on your cellphone so you will remember it later on.
Becoming well-versed in many platforms will help you when designing multiple websites. PHP, MySQL, and Java will all come in handy in the future if you get into website design. It does not matter if you are designing for yourself or for your friends, you should work on becoming a multi-faceted web designer.
It is essential that you check your website's statistics often. This allows you to find out who's visiting your site. You can also find which pages they are using most often. This will show you which areas need updating to entice people back again and again.
Use copy and paste to help you create multiple webpages for your website. Do not write new HTML code every time you start a new page. Copy and paste the main structures of your code and make small changes if you need to. You can use the master copy of that main section of code as many times as you need to.
You need a site map to help people navigate your site. Site maps do two things. It is going to make your site and business more easily understandable for your targeted visitors. They're able to find what they're searching for and see what your site offers just by using the map. Second, the site map furthers your SEO efforts. The search engines are able to locate your site better this way.
If your site contains a corporate logo, ensure that clicking it takes visitors back to the home page. These days, people expect to be able to click on a logo to go to a site's main page. A static logo can irritate your users, because that makes them hunt for a separate "Home" link. You will find that a clickable logo will have a positive impact on your visitor's stay on your site.
Try making a favicon to use on your site. A favicon will help users who add your website to their bookmark see your page more easily. When they pull up their bookmarks, your memorable favicon will stand out. You should design the favicon so that it is logical for your theme and logo.
Find free images to use on your site. These images can be found throughout the Internet and are often as high-quality as those you have to pay for. Not having to pay for images can really free up your budget, which is always a plus.
It is important that you use descriptive titles on your website. For example, Google "untitled document". You will see what a common mistake not providing a webpage or website with a title is. Take care to name your website correctly from the beginning. Search engines use site names to determine what sites are about.
So, now that you have been taught about different ways to design better websites, you should feel confident in your abilities to design great websites going forward. Continue to learn more about web page design, and your website will reap the benefits!
Obtain feedback from others on the design of your site. Web design comes from one person, and though you might find the site useful and appealing, others could find it tedious and irrelevant. Speak to people in your target market, if you can, and find out what they think.


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This is just a preliminary information blurb but I'll be spinning in Asheville NC on Sat July 28th with DJ Nareau for their dark faerie ball. Now Asheville is also holding a street festival that weekend so if anyone is planning on staying overnight booking a hotel ASAP would be a good idea. Parking also could be an issue but Nareau is looking into that. The venue, Joli Rouge, is on 130 College Street a few blocks S of I-240 for distance purposes.
The rest of the info as well as the flyer will be up in a week or so from Nareau. Just thought I'd start the ball rolling and get everyone up to speed. Looking forward to seeing as much of you all as I can to come out and enjoy Asheville's finest goth night.
I might have to beg a ride off of someone as my last ride fell through, I can pay both gas and hotel if need be. Msg me.


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Had the sirloin with mashed potatoes and broccoli. It was good. It would have been nice of there was at least one appetizer. The only kid friendly gluten free option is pizza. I do appreciate the gluten free dessert.
|Celiac friendly
I had the chicken quinoa bowl and it was quite tasty. The lunch portion is pretty big. We purchased two GF pizookies to go so I haven't tasted those yet but they smell wonderful. We will definitely return. Don't let the single dollar sign on the app fool you though because without alcohol including two deserts our ticket was $44 before the tip. Despite the cost it was worth it to me. I definitely plan on returning.
Very helpful with a menu that has a list for all allergies. And the gluten free pizookie is so yummy!!
The only gluten free items my 2 yr old will eat on their menu is the pizza. It would be nice if they had a gluten free appetizer to offer. We went to try the pizza, and it was pretty good.
Wasn't too pleased with the pizza, although, thanks for offering GF alternatives.
Just had the best lunch. They take gf and food allergies seriously . This is going to my family dinner place once a week Grilled salmon over salad rocked
Quite good food and a variety of gf options. The staff seems pretty well-informed, too. When two members of my party were going to share a gf meal and the non-celiac ordered a regular beer, our server caught that and confirmed that she was ok to have that gluten-riddled beverage.
This restaurant has taken the time to prepare a pretty decent menu that not only lists the gluten-free items, but also other allergens. They even have gluten-free beer!
461 West Esplanade Drive, Oxnard, CA 93036
They will give you a gluten free menu if you ask, 2 to 3 pages, then the rest tells of what is in everything for allergy reasons. I have been diagnosed with celiac disease and I am going through chemotherapy. I ate a gluten free chicken dish, and a gluten free salad that tasted good. I had a rash and a stomach ache the next day but that could be from chemotherapy, so I am rating this unsure for know.
1370 Frazee Road, San Diego, CA 92108
GF items are marked on the menu. Not all GF items are made in a designated area. I felt safe ordering and eating here and I did not get sick.
|Celiac friendly
6622 E. Superstition Springs Blvd., Mesa, AZ 85206
Waitress explained her child is celiac, so she went out of her to way to ensure my dinner was completely gluten free. My meal took a lot longer than my families.
|Celiac friendly
6000 Sepulveda Blvd., Culver City, CA 90230
Wait staff were knowledge of celiac and cross contamination risks. They advised me of their procedures, they have a separate part of the kitchen gluten free food is prepared and have procedures to use clean gloves and separate utensils. Separate gluten free menu. Fries were a no go due to shared fryers. I had salmon with mashed potato and my 9 year old had gluten free pizza and the gluten free chocolate chip pizookie. Everything was delicious and we had nil issues later.
2715 Fairfield Commons Boulevard, Beavercreek, OH 45431
Kids loved the gluten free pizza and gluten free chocolate chip cookie with vanilla ice cream, no reaction. Server understood Celiac disease.
|Celiac friendly
190 Nut Tree Parkway, Vacaville, CA 95687
So so good! Not only did our server check on all my concerns but the gluten free menu is, I think the best in town that I have found! I normally dread going out to eat but they made it easy and delicious!
|Celiac friendly
2455 Medical Center Pkwy, Murfreesboro, TN 37129
Dining out with 3 celiacs is always an adventure. We found this place along our route for a road trip and were pleasantly surprised. Good menu, friendly service and none of us got ill. That makes for a big win in our books. The icing on the cake was a gluten free "pazookie"- warm chocolate chip cookie with vanilla ice cream. Yum! We rarely get dessert out so it really was five stars for us. The one gluten-eater among us also enjoyed his meal!
11700 Princeton Pike, Cincinnati, OH 45246
My husband and I have been to several BJ locations, in multiple states, and always encounter the same problems. The menu has reasonable options for gluten free, but the service is horrendous. Dinner with ordering water and two salads should not take over an hour and a half. The waiters and waitresses never come to check on us, so if you don't get it with your meal, don't expect to get it at all. We have desperately wanted to enjoy this restaurant chain and have decided now, after many bad experiences, that we won't be returning.
|Celiac friendly
192 Hanes Mall Cir, Winston-Salem, NC 27103
Knowledgeable staff and awesome food! I've ordered a pizza 2x from here and it is the best GF crust/pizza I've had - tastes just like the real thing! They also have a very extensive menu. Ask for Shawn Or Jasmine, they went above and beyond to make sure that every item was truly GF. The GF Pizookie is made on separate pans than the regular ones and they're very tasty too! We will be going back.
11905 Gateway Blvd., El Paso, TX 79936
Great gluten free options! The broccoli cheddar soup is great and so are the GF salads! It's also great to get to order dessert without worrying. Have never had a bad reaction in this restaurant. Definitely recommended!
3924 Lenox Avenue, Charlottesville, VA 22901
Very good pizza crust, and their pizookie can be made gluten free. SO good. Didnt get sick here, but the service has been slow the past couple of times.
|Celiac friendly
16060 Beach Blvd., Huntington Beach, CA 92647
Just had a pizza there. It was the best gf pizza I ever had. Will definitely go back there. I had no reaction at all and I react on small traces.
|Celiac friendly
23002 Eureka Rd, Taylor, MI 48180
I had a really great burger, they were allergy aware and careful with my food. They have gluten free chocolate chip cookie desserts!!!! With ice cream on top. It was SO good. I could go back every day for that dessert!. I have celiac n did not get sick afterward, so I will be back!! Can't wait to try the pizza! ETA: have been back many times, gluten free pizza is tasty! Love that they have separate work space for allergies, and I have safely eaten here. Still really enjoying that gluten free cookie! 😋
|Celiac friendly
106 Main Street, Newport Beach, CA 92661
Like all BJ's, excellent choice for GF options
|Celiac friendly
2609 S. Stemmons, Lewisville, TX 75067
Great staff, good food and gf beer
665 N Krocks Rd, Allentown, PA 18106
UPDATE: Returned and was told by the manager that they do not have a separate fryer and they do not recommend anything fried. GAH. I wonder if they had recently changed the oil the last time I ate here.. so upset that I was lied to the first time. Didn't get anything fried this time and had a small reaction to gluten... Oh my goodness, I had a burger topped with bacon and brisket with BBQ sauce and a side of fries. It was phenomenal. Also had chips and guacamole for an appetizer (separate fryer) and ice cream for dessert! No reaction and I'm very sensitive. Definitely feel safe here after ordering so many different items during rush hour on a Saturday night. Will be back.
7211 166th Ave NE, Redmond, WA 98052
Not impressed. VERY limited menu. Thought I could try guacamole and chips with the GF soup, but the chips have flour. And 2 hours after lunch and service was sssslllloooooowwww.
939 Broxton Avenue, Westwood, CA 90024
5 stars alone for the gluten free pazookie. One of the best gluten free desserts out there in my opinion.
|Not celiac friendly
11520 4th Street, Rancho Cucamonga, CA 91730
We ordered gluten free cheese pizza and a bazookie. But the time we got to the car my two youngest(with Celiacs) were throwing up. I worried that it could be a coincidence so I had them take the urine test the next day to see if they had gluten... sure enough they had enough gluten make the test positive which was equivalent to 1/4 of a piece of bread. That is not cross contamination- that is something gluten in the recipe! Sooo sad because we loved BJ's
|Not celiac friendly
1001 E Whitestone Blvd, Cedar Park, TX 78613
Tried here one night. Ordered off gluten free menu a steak, steamed broccoli with no seasonings/butter, and a baked potato with no butter/toppings. Sad to say I got glutened. Guessing cross contamination came from the grill.
12100 Pines Blvd, Pembroke Pines, FL 33025
Wowsers! A fabulous menu with a delicious burger & gluten free berry cider. Highly recommended! Many items & educated staff...
Manager assured us they are careful - have not gotten glutened there . Just wish they had more options to choose from
10515 MoPac Expy, Austin, TX 78759
I am celiac and one person who went with me has not eaten gluten for years. We both got sick. Two others not on a gluten free restriction did not get sick. Not sure if it was the kitchen that day or not celiac safe but, I will not return.
|Celiac friendly
411 S College Mall Rd, Bloomington, IN 47401
Super good gluten free food! There's lots of options (including desert!)
7852 Mall Rd, Florence, KY 41042
My husband had their pizza and really enjoyed it. They don't have a separate menu but GF items on menu are marked. Several decent GF options but steaks are not due to seasoning. Gluten sensitivity-not Celiac.
13930 Promenade Commons Street, Gainesville, VA 20155
I ordered an item that was labeled gf. I told me waiter I had celiac disease, my order was labeled with that and allergy. Was delicious and did not make me sick. Great experience
204 E. Via Rancho, Escondido, CA 92025
Ordered off of the gluten free menu and requested a house salad for my side. The backup server brought out the salad with croutons on it, I told her I had requested my meal to be gluten free per having celiacs and she rolled her eyes and walked off and came back about a minute later having given me the same exact salad with the croutons just pulled off. Notified the server assigned to my table that I could not eat the salad because it was brought with croutons and she apologized and brought me a fresh salad almost immediately. The experience left me feeling uneasy about consuming the food, but I was okay this time and did not get sick. I went here again recently and the server of our table didn't seem to really understand the requests. We kept having issues at the table about food being forgotten or incorrect and with this experience, I feel like the server may have been confused or overly busy which resulted in my food being contaminated and me being sick. All in all, some of the employees are knowledgeable and sympathetic to people whom have celiacs while others treat you as an inconvenience for making them do their job. But this place seems to be a hit or miss. I've had great experiences here as well.
17316 Valley Mall Rd, Hagerstown, MD 21740
The gluten free menu was pretty extensive. Pizza crust was yummy.
201 East Interstate 20, Arlington, TX 76018
Waitress was very patient with my needs! I required gluten and dairy free, so kinda difficult but she was so helpful. They have a separate GF menu, and several options to chose from.
10690 N. De Anza Blvd., Cupertino, CA 95014
There burgers aren't on the GF menu, but they are GF if you get a GF Bun and carefully select your toppings. Bummed that no fries are GF, not that the chips are GF.
|Celiac friendly
1045 E. Harriman Place, San Bernardino, CA 92408
Amazing food very good service highly recommended.
|Celiac friendly
8761 Vineland Avenue, Orlando, FL 32821
I have visited multiple locations and have had no issue! Love the pizookie and I had the california chicken sandwich.
|Celiac friendly
The waiter was knowledgeable with my gf burger. He explained what was gf and not. He doubled check an item for me to see if it was cross contaminated. They came out with my order and continued to check on my to make sure I was okay m. Didn't get sick
|Not celiac friendly
1861 Carl D. Silver Parkway, Fredericksburg, VA 22401
Had dinner there tonight. Ordered a burger that was labeled GF on their menu. Asked if the fries are GF. Server said she'd check and if they are do I want them? I said yes. She brought me the burger and fries. Fries were crispy and I thought wow, these are great! Now tonight I'm HORRIBLY SICK. I asked another person I ate dinner with what they thought of the fries and they said they definitely seemed breaded because they were so crispy. DO NOT trust them to even do what they say! She said she'd check if they were GF. CLEARLY, they were not. I'm so so sick now. Very disappointed
|Celiac friendly
3155 W Chandler Blvd, Chandler, AZ 85226
Limited item GF items on the menu. Waiter was knowledgeable and friendly and spoke to the chef. My quinoa bowl was yummy. The other dinner option was a chicken/bean dish. Highly sensitive and I didn't get sick. Bonus for this place was the GF chocolate chip cookie with vanilla ice cream option! We indulged and it was worth every calorie.
2514 W International Speedway Blvd, Daytona Beach, FL 32114
Amazing! Order a pizookie, you won't be disappointed! Also the pizza was wonderful
2425 W. Memorial Road, Oklahoma City, OK 73134
Lots of options and was ultimately safe for celiac... they did have to remake a salad even after the allergy note but they did actually remake it and were very prompt about it. Didn't try the pizzas which seem ripe for cross-contamination. The gf cookie was great!!
|Celiac friendly
190 Nut Tree Parkway, Vacaville, CA 95687
I was told by management that they source all their gf foods from certified gf sources. I have never had problems. Love their gf pizza and gf pizookie is amazing
|Celiac friendly
5616 Spectrum Dr, Frederick, MD 21703
Love the pizza and the pzookie. They are always super helpful in finding a good cider I can have to wash it down.
4720 S Hulen St, Fort Worth, TX 76132
The staff was good about showing what options were gluten free but we asked for a GF Pazookie & I think they brought us a regular one. Stomach was killing me after the visit... probably safe if you just do not get dessert
|Celiac friendly
7327 Market St, Boardman, OH 44512
Delicious gluten-free pizza! I had to question if it was gluten free because it was SO good. (It totally was lol.) Plus, they even have a gluten free chocolate chip pizookie, which is a fresh baked cookie with ice cream on top! I'll definitely be back!
1807 Palm Beach Lakes Blvd, West Palm Beach, FL 33401
I read there allergy menu and there's wheat in a lot of their items also soy is in everything but there pizza with no toppings.
1101 N. Central Expressway, Plano, TX 75075
I really like the gf pizza. The burgers are not bad, but clearly not the best I've ever had. Stay away from the fries. They have flour on them. The staff are very helpful, but not knowledgable.
|Celiac friendly
5447 W. Loop 1604 North, San Antonio, TX 78253
Tested safe with Nima Sensor for GF pizza and GF pizza cookie. Marcus is very knowledgeable about cross contamination. Recommend. Went back another day with another successful GF test with Nima
|Celiac friendly
5616 Spectrum Dr, Frederick, MD 21703
Had a wonderful meal here. I'm very sensitive to cross contamination and didn't have any issues. Pizookie dessert (chocolate chip cookie with ice-cream) was delicious. Service was nice also!
|Celiac friendly
Delicious GF pizza, service was quick too
|Celiac friendly
6000 Sepulveda Blvd., Culver City, CA 90230
Great gluten free pizza, specific Gluten Free menu. Went there multiple times while staying in LA, they seem to be very knowledgeable about GF - never had a problem afterwards
1325 Rancho Vista Blvd., Palmdale, CA 93551
Separate gluten-free menu but was worried from the start since waiter wasn't sure what gluten-free was. He tried but not a gluten free meal.
|Celiac friendly
2917 Eastland Center Drive, West Covina, CA 91791
Ordered gf pizookie and bbq chicken chopped salad online. On both items i put comment that I have a gluten allergy. For salad, needed them not to include onion strings and asked for that. Both items tested safe with Nima sensor and I didn't get sick. A couple years ago pretty sure I got sick here, but this time verified safe. Next time maybe I'll try the pizza.
|Not celiac friendly
1001 E Whitestone Blvd, Cedar Park, TX 78613
I thought I'd be safe since I ate there just fine at another location, but I had the same gluten free pizza and got sick almost immediately. It tasted good, but was not worth the stomach and gut pain that followed.
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text: BREAKING NEWS – Washington, D.C. – The White House reportedly hid the extent of the Office of Personnel Management regarding being hacked. The OPM, led by director Katherine Archuleta, initially denied that security clearance forms had been compromised in a massive cyberattack, despite being told the opposite by the FBI. House Oversight Committee Chairman Jason Chaffetz believes that the true number of people affected could be as high as 32 million, and called for Archuleta to step down. Archuleta acknowledged that she initially ignored the report given to her by the FBI because she thought she was being pranked and laughed it off. She pointed to several incidents in the past month when FBI agents left some phony vomit on her desk, put a whoopee cushion in her seat, and sent her a "computer generated video" of Joe Biden actually saying something intelligent.


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Baked Farfalle with Cheese
My kids love pasta for their lunchboxes. This one is our all time favorite. Instead of farfalle, we usually use penne or macaroni. It's really easy to make, just boil the pasta al dente, add bechamel sauce/white sauce, add shredded cheese on top of it then bake for half an hour.
My Kind of Bechamel Sauce/White Sauce
60g butter, chopped
garlic, chopped
1/3 cup plain flour
4 1/2 cups whipped cream (liquid)
75g parmesan cheese/cheddar cheese, finely grated
1/4 teaspoon salt
good pinch ground nutmeg
Directions :
Melt butter in a medium saucepan over medium-high heat until foaming. Add garlic, sauteed until fragrant, then add flour. Cook, stirring, for 1 to 2 minutes or until bubbling. Remove from heat. Slowly add whipped cream, whisking constantly, until mixture is smooth. Return to heat. Cook, stirring with a wooden spoon, for 10 to 12 minutes or until sauce comes to the boil, thickens and coats the back of a wooden spoon. Remove from heat. Stir in parmesan, salt and nutmeg.
Sometimes I add smoked chicken, mushroom, cubed carrot and chopped parsley in the sauce.
Mix together cooked pasta and sauce in the baking dish. Add shredded cheese. Then bake in a preheated 350 degree F(175 degrees C) oven for 30-45 minutes. Let stand 10 minutes before serving.
Labels: pasta
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text:
Environmental defenders being killed in record numbers globally, new research reveals
Activists, wildlife rangers and indigenous leaders are dying violently at the rate of about four a week, with a growing sense around the world that 'anyone can kill environmental defenders without repercussions.
Last year was the most perilous ever for people defending their community's land, natural resources or wildlife, with new research showing that environmental defenders are being killed at the rate of almost four a week across the world.
Two hundred environmental activists, wildlife rangers and indigenous leaders trying to protect their land were killed in 2016, according to the watchdog group Global Witness – more than double the number killed five years ago.
And the frequency of killings is only increasing as 2017 ticks by, according to data provided exclusively to the Guardian, with 98 killings identified in the first five months of this year
Read this shocking article in full here.


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Makers in craft and design activities have a huge potential to contribute to community development and social change. In the wake of the UK riots, a Facebook group – The Change Makers – has been formed to explore how craft can be a stronger and more focussed force for positive social change. Given the failure of our political parties to move beyond their predictable responses to the crisis, we aim to develop a "Makers' Manifesto". We want to draw attention to positive practical examples and set out the case for craft as a force for empowerment and hope. We have set up a further webpage to source ideas for the manifesto.
The group has attracted over 130 members in just over two weeks. We have held an initial meeting in Dundee, contributed to a conference in Glasgow, and expect to hold a further meeting in London. If you believe that craft has a positive contribution to make to social change in the world today, we invite you to join us.
Already the Facebook group has attracted a great deal of debate and discussion. Much of this has helped to draw attention to exemplary projects and initiatives that demonstrate the social value of making. Over the next few weeks and months we will be drawing all this together in our Manifesto.


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Looking to upgrade your home bar? Neiman Marcus' selection of bar and wine accessories will set you up for hosting that perfect get-together for your friends and family. Our liquor accessories are just what you need to turn your home bar into a mixologist's dream. Serve those special cocktails with ease and in style by shopping from our wide collection.
If you're looking for luxurious items, our decanter, coaster, and barware sets are sure to add liveliness to your bar area. Our wine racks beautifully store your Pinot noir, and our wine openers are designed to easily open a bottle for any occasion.
We offer an assortment from leading designers that are suitable for casual affairs as well as glitzy evenings. Shop Neiman Marcus for the finest accessories for your home bar.


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The # 1 Natural Superfood on The Market Today
Turmeric Plus is one of the most popular today an all-natural superfood supplement that has an anti-inflammatory effect and is therefore widely used in medical practice. Manufactured from the root of the perennial herbaceous plant of the Ginger family called turmeric (Curcuma longa).
This potent dietary supplement made in the US in a registered FDA and GMP certified laboratory. At present, this natural product is appreciated by the health community for its powerful medicinal properties and numerous health benefits. The herbal formula of Turmeric Plus is effective for supporting weight management, helps normalize blood pressure, improves cognitive function.
What is Curcuma?
Curcuma, better known as turmeric, is a spicy-aromatic, and also a medicinal plant which belongs to the family of ginger. This plant has more than fifty species, of which only three are grown on an industrial scale with the aim of producing spices and medicines. The greatest spread in the quality of spicery was Curcuma Longa, other names – Curcuma Domestic.
From the dried rhizomes of this plant by extraction method, produce a golden yellow powder which is known as spicy turmeric. The natural range of these plants includes tropical South-East Asia, India, and the East Indies, but they are also widely cultivated in other parts of the world that offer a warm, humid climate. Historically, for many centuries, turmeric has been used in Ayurvedic medicine to treat many diseases.
>> Visit Official Turmeric Plus Website <<
The Ingredients
FDA Registered Manufacturing Facility, 100% Natural Ingredients
Turmeric – is the main part of the widely known Middle Eastern and Asian spice called curry. Perhaps Curcuma is one of the most powerful medicinal plants on the planet. This oriental plant has a lot of medicinal properties that are used both in folk and in official medicine for the treatment of inflammatory diseases, including arthritis.
Curcuminoids – are the active components of Curcuma are curcuminoids – powerful antioxidants of the group of polyphenols, the most famous of which is curcumin (a pigment that gives the Curcuma a characteristic golden color and a unique aroma). Long-term studies have proved the biological activity of curcumin, in particular, high anti-inflammatory, anticancer and antidepressant effects.
BioPerine – a major drawback of curcumin is its low digestibility: active substances are poorly absorbed and are quickly eliminated from the body. To solve this problem in the formula Turmeric Plus was added Bioperine, product sourced out of piperine (black pepper extract) which proved effective in increasing the bioavailability of curcumin.
Amazing Health Benefits of Turmeric
Turmeric has incredible benefits that are beneficial to your body and health. The benefit of this is that it can potentially aid in weight loss and support healthy weight management. How much weight you can lose depends on various factors of your lifestyle, such as diet and regular exercise.
Turmeric is included in the list of the most powerful natural medicines created by nature itself. It has been used in India for more than two and a half thousand years as a natural anti-inflammatory drug.
The product contains bioactive substances called curcuminoids, the most important of which is curcumin. It is the main active ingredient which is a very strong antioxidant.
In ancient India and China, Curcuma was endowed with special properties that can purify the body. Modern science has proven that curcumin does indeed have anti-inflammatory, anticarcinogenic, antimutagenic and antioxidant effects. Therefore, at the present time, scientists are working on the creation of new drugs with its use.
Today, the curative properties of Curcuma are recognized throughout the world. Many scientific studies show that it has great benefits for your body and brain.
Here are just some of the medicinal properties of the product:
- Clears the blood and reduces blood pressure.
- Maintains a normal intestinal microflora.
- Improves memory function.
- Helps in the treatment of Alzheimer's disease.
- Stimulates the digestive process.
- Regulates metabolism and stimulates the digestive process.
- Helps to burn fat and lose weight fast.
- Discharges toxins from the liver.
- Reduces the level of harmful cholesterol in the blood.
- Normalizes the composition of blood and improves its circulation, stimulates the formation of erythrocytes in the blood.
- It is useful for cholecystitis since it has choleretic and bile-forming properties.
- Strengthens the heart muscle and is useful for the work of the heart.
- Helps to remove toxins from our body.
- Reduces pain and inflammation in arthritis, rheumatism, arthrosis.
- Helps in the fight against cancer, since it is a powerful antioxidant.
- Is a good way to preserve youth and beauty.
- Improves the skin condition, gives the skin a youthful and healthy appearance.
How Long Does It Take For Turmeric Plus to Work?
The positive effects obtained with the use of this dietary supplement based on herbal cultures are permanent and do not disappear after discontinuation of the product. It is established that these veggie capsules does not cause a negative effect of yo-yo associated with weight loss, as some other supplements may do.
How to Use Turmeric Plus
Each bottle of Turmeric Plus Dietary Supplement contains 60 capsules. The manufacturer of product recommends taking 2 capsules during the day, one capsule at lunch time and one capsule in the evening during dinner. For best results, it is recommended to take this superfood nutritional supplement for four months.
Where to Buy Turmeric Plus
If you are really interested in purchasing Turmeric Plus, then you can order the product online safe and easy through the brand's official website. Currently, the product is available in 3 different packaging options. Do not forget to consult your physician before using this product.
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Clive Jenkins
Mr Jenkins is a sturdy employee that also functions as the spokesperson for visiondivision among a lot of other things.
He joined the team in 2006 and is now a part of the vd family.
He has a long and impressing background in administration and public relations from different organizations in his motherland USA and he is the bedrock and the lighthouse of visiondivision.
We are very grateful to have this great man among us and we hope that we will have many fruitful years ahead of us.
You can click on to www.visiondivision.com and under the extra section, you can see Mr Jenkins answer some of the most frequently asked questions regarding the vd crew.
Thursday, June 4, 2009
Employee of the month
Upplagd av visiondivision kl. 11:37 PM
Etiketter: dallas, employee of the month, mr jenkins, over there, spokesperson, visiondivision, yankee
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Contamination forces Ontario First Nation to close school, fly in bottled water
Weagamow First Nation dealing with water crisis for a week now
By Martha Troian, CBC News, November 14, 2016
People in a northern Ontario First Nation are in crisis mode after the community's drinking water was contaminated because of broken pipes, forcing bottled water to be flown in and the school to be closed for over a week.
Photos shared on social media show discoloured water that's come out of taps on the Weagamow First Nation — also known as North Caribou Lake First Nation — located around 320 kilometres north of Sioux Lookout, Ont.
Bottled water flown in
"All last week there was no school," Kanate said. "We closed down for the whole week … There's no water in the community."
The problem stems from four ruptures that were found in pipes that carry water from a treatment facility to homes, according to Chief Dinah Kanate. The pump from the water plant itself is also broken, she said.
"The water system leak has now been isolated and work is underway to restore water service as quickly as possible," read a statement from Indigenous and Northern Affairs Canada. However, the community could be drinking bottled water for at least two weeks, the department said.
Nishnawbe Aski Nation, a political organization representing First Nations in northwestern Ontario, has been delivering bottled water to the community since Nov. 8. A total of 800 cases of water have been shipped to the community so far.
A spokesperson from Nishnawbe Aski Nation said the water treatment facility was built in the 1990s and had been operating over capacity with limited human resources for maintenance and repairs.
The Liberal government has vowed to end water problems in First Nation communities within five years and recently announced that $4-million has been earmarked to fix water systems in northern Ontario — though Kanate remains skeptical.
"Right now the way our situation is, I haven't seen anything," Kanate said.
Children with rashes
Some people in the community of 900 are also reporting an outbreak of skin rashes among children.
Julie Kenequanash, who has two children, said a rash broke out on her eight-year-old son's face after taking a shower. A doctor has prescribed an antibiotic to treat it.
"He doesn't want to take a shower. We've been living on boiled water and bottled water," said Kenequanash.
Her 17-year-old son accidently drank a cup of water two days ago. He is now complaining about a sore tongue.
According to the Indigenous Affairs website, there are 139 First Nations under boil-water advisories; 35 of those communities are represented by NAN.
Posted on November 14, 2016, in Uncategorized and tagged contaminated water, water contamination, Weagamow First Nation. Bookmark the permalink. Leave a comment.


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Bore-tips® and Gun-tips™ by Swab-its® is the newest technology in firearm cleaning that offers FAST PATCHLESS CLEANING.
Bore-tips® are a tough, reusable foam tips engineered for a specific tight bore fit providing a 360 contact with all the lands and grooves of the rifling. No more messing with jags or having to load poor fitting patches to the cleaning rod. Bore-tips thread onto a standard 8-32 cleaning rod.
Bore-tips® and Gun-tips™ perform better than patches and offer complete coverage and delivery of cleaning solvents and oils to the firearm. They are both reusable and can be washed, offering a very economical way to keep your firearm clean.
Swab-its® Firearm Cleaning Swabs Benefits:• Each tip is reusable and can be cleaned with solvents or soap and water• Fiber free, will not shed or leave lint behind as cotton will• FAST PATCHLESS CLEANING; solves the shortcomings of the jag and patch• A tight bore; filling the lands and grooves of the rifling, not sliding over the top like a patch• Quick threading on a standard 8-32 cleaning rod• Can be used with most commercially available solvents and oils
Please Note: Bore-tips are not recommended for use with solvents designed to remove plastic. Bore-tips are NOT compatible with both G96 brand and aerosol solvents.
Swab-its® foam applicating swabs are the perfect tools for precision cleaning and applying materials. Manufactured by Super Brush, LLC, the leader in foam swab technology.
Swab-its.com is a registered trademark of Super Brush, LLC.


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Wari-Bateshwar is the site of an ancient fort city dating back to 450 BC situated in the north-eastern part of Bangladesh. This 2500 years old site is a significant archaeological discovery. It challenges the earlier notions about the existence of early urban civilization in Bangladesh.
The site is about 75km from Dhaka situated near the Wari and Bateshwar villages in the Belabo Upazila of Narsingdi District. It was discovered in the early 1930s by a local school teacher, Hanif Pathan. However, formal excavation started only recently in 2000. The current scientific study is being carried out by a team from the Archaeology Department of Jahangirnagar University led by Professor Sufi Mostafizur Rahman.
Prof. Rahman believes that Wari-Bateshwar is the rich, well planned, ancient emporium (a commercial city) "Sounagora" mentioned by Greek geographer, astronomer, mathematician Ptolemy in his book Geographia. The other emporia mentioned in Ptolemy's work include Arikamedu of India, Mantai of Sri Lanka, Kion Thom of Thailand. All of these were the most ancient civilisations in their respective regions, each was a river port, and all of them produced monochrome glass beads. The artifacts found at Wari-Bateshwar bear similarity with those found in the other emporia sites.
According to researchers, the discovery of Rouletted Ware, Knobbed Ware, stone beads, sandwiched glass beads, gold-foil glass beads, Indo-Pacific monochrome glass beads and importantly its geographical location indicates to Southeast Asiatic and Roman contacts
Excavation also unearthed the presence of pit-dwelling. The discovery of a pit-dwelling is the first of its kind in Bangladesh. People used to live in these small ditches. The pit-dwelling is a Copper Age or Chalcolithic artifact. Similar pit-dwellings have been found in India and Pakistan which are believed to be 4000 years old. The unearthing of a 180-meter long, six-meter wide and 21-35cm thick road with a by-lane points to very early urbanisation in this area. Before the discovery of this, the widely held view was that urbanisation occurred later than what Wari-Bateshwar Ruins indicate. Courtesy: (http://www.parjatan.gov.bd)
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In this atmospheric supernatural thriller from Korea, Yong-hyun (Kim Myung-min) is a cab driver who is looking for a new place to live. He rents an apartment in a run-down building that's home to a handful of losers and eccentrics, one of whom tell Yong-hyun that his flat is haunted by the spirit of a previous tenant. Yong-hyun makes the acquaintance of Sun-yeong (Jang Jin-yeong), an attractive but seemingly disturbed woman, and one night she arrives at his door with an unusual request -- she's killed...more
All Sorum cast + crew photos
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
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- Browse the latest discount offers on hotel accommodation
- Hotels across the Canaries, Med, Caribbean & Europe
- Hotel deals for families, adults only or business
H10 Hotels discount code 2019/2020: Cheap hotel deals
As one of Spain's leading names in accommodation, H10 Hotels prides itself on its modern, chic style and first rate customer service. The latest H10 Hotels discount codes and online deals let you save while booking stays at any of its properties across Europe, the Mediterranean and the Caribbean for 2019/2020.
Top H10 Hotels discount codes & special offers 2019/2020:
Here you'll find the current H10 Hotels discount codes and online deals for 2019/2020. Whether you're booking a city break or beachside retreat, there's surely a saving to be had with any applicable promotion or special offer:
Why book with H10 Hotels?
H10 Hotels is a fine Spanish hotelier which dates back to the 1980s. It has more than 40 hotels across 17 destinations in Europe, the Mediterranean and the Caribbean, with further expansion plans in the pipeline for the coming years. You can rest assured that any booking with this award winning company is guaranteed to include top rate service and a fine stay in any of its characterful properties.
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For a touch of luxury look no further than the all inclusive Ocean by H10 Hotels. Located exclusively in the Caribbean, these immaculate beach resorts are as elegant as they are cosmopolitan. They harness the very best style while offering unrivalled service with every detail included in the price.
You'll also find an Ocean resort to suit every type of holidaymaker including families, couples and groups. Make the most of your time with one of Ocean by H10 Hotels' experiences from scuba diving and yoga, to bowling and tennis.
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H10 Hotels sits somewhere between the giants of the hotel industry and boutique hotels. It offers reliably comfortable and modern accommodation in popular holiday and business destinations, both in the city and by the beach. If you like the sound of staying at one of these properties, book your break in any of the following locations:
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From luxury beach resorts to plush city centre hotels, H10 Hotels has something for everyone in busy cities and seaside favourite in Europe, the Med and the Caribbean. Make sure you get the best deal by using the latest H10 Hotels discount codes and online offers for 2019/2020. Can't find what you're looking for? Check out our full collection of hotel deals from other leading companies.
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