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She Wasn't Ready: Dude Knocks A Woman Down With A Clean Sweep!
Uploaded February 02, 2018
Dude Knocks A Woman Down With A Clean Sweep. @huntwooddex. Posted By Persist
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2019 Best Places to Live in Pope CountyAbout this List
- Town in Arkansas
- 112
Works Here: My experience in Russellville, Arkansas is great. I attend college and work there. The thing I love most about Russellville is that there are tons of affordable places to eat! One thing I would be interested in seeing would be adding a red lobster, joes crab shack, or olive garden to our area!
- 29,147 Population
- Town in Arkansas
- 3
Current Resident: I love the small setting in Pottsville. The school is amazing! It's not too small, not too big. There is plenty of land if you want to live in a country setting and there are housing additions coming if you like a neighborhood setting. While there aren't many businesses in Pottsville, it is about five minutes away from Russellville, which has numerous places to eat and shop.
- 3,072 Population
- Town in Arkansas
- 2
Former Resident: Hector, Ar was one of the most influential places I grew up. Everyone in this town was kind and caring. It taught me to be who I am, not who everyone wants me to be. However, it does have its flaws. The diversity in hector lacks. Which also means there isn't much culture there. It is a great town besides its flaws. The school is beyond amazing. I was learning at a faster rate than I ever have. It is also very rural, so you have plenty of area to grow your own food.
- 574 Population

subset: commoncrawl


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Dunecrest American School
An Ivy League-inspired summer camp? Sounds good to us. Esol Education and Ivy Camps USA have partnered together to host a programme at Dunecrest American School for kids aged five to 12.
Inspiring young ones to think creatively while building their confidence and helping them discover their passion, expert advisors taking part in the two-week sessions include a Hollywood producer, a global business owner, a neuroscience engineer, a professional athlete and an entrepreneur.
Starting early August, kids will have access to world-class learning facilities at the school's campus at the camp, with daily meals and snacks included. Ivy Camps' Dubai offers three tracks, Build Your Own Business, Performing Arts and the Junior Ivy Program.
Dhs1,950 (per week). Aug 4-8, Aug 11-15, 9am-3.30pm. Dunecrest American School, Wadi Al Safa, ivycampsdubai.com.
Ora Nursery of the Future
Dinosaurs may still exist, and we have the summer camp to prove it. Young explorers aged one to four will delve into a prehistoric world – right here in Dubai – with activities where they'll learn while having fun through augmented reality, science experiments and sensory concepts such as constructing their own dino glow garden.
Kids will be divided according to age group for tailored learning materials that showcase the best of Jurassic times.
From Dhs250 (day rate), from Dhs1,050 (weekly rate). Jun 30-Aug 29, 8am-12.30pm (half day), 8am-6pm (full day). Emirates Towers, DIFC, ora.ae.
Splash 'n' Party
For kiddies who love splashing about, and more, this camp will be filled with activities including water aerobics, robotics, a science lab and even some culinary fun. From 9am-11am, kids will have access to splash pads and slides, the bungee trampoline, dunk tank and more. They can do everything from going on treasure hunts to zip lining and putting on a show.
From 11am-2pm, a line-up of indoor programmes such as robotics, board games, table tennis, boxing, archery and air hockey will keep them cool while they enjoy some tasty kids' meals.
Dhs499 (per week). Jul 7-Aug 29, 9am-2pm. Al Safa 2, Jumeirah, splashnparty.ae.
We're totally ready for summer.
Three top creative summer camps in Dubai
From dinosaurs to Ivy League programmes, kids will stay busy this break
Dunecrest American School
More from Activities
The course is based around books including The Gruffalo
Get free kids' club access and a boat ride
The theme park will be slashing the price of their tickets across the Eid holiday
Bob the Builder, Fireman Sam and Barney and Friends join show
Tashkeel's programme also includes paper-making, acrylic painting and more
Visit the furry family and check out the exclusive pop-up art exhibition


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There's an abundance of guitar information out there on the web, some good, some not. I stumbled across Justin Sandercoe's site a year ago and now tell everyone about it. The lessons are conveyed so clearly, concisely and in the most congenial way. The site is laid out logically as well so you can to go straight to your area of interest... beginner, blues, rock, folk, jazz, rhythm, fingerpicking... it's all there and more. Spend ten minutes with Justin and you'll not only play better but feel better too. From novice to know-it-all, everyone will learn something from Sandercoe.
What ultimately sets these rock guitar lessons apart from other offerings is the ability to submit a video for review using the ArtistWorks Video Exchange Learning® platform. Paul reviews each submission and records a video response, offering specific guidance to take your guitar playing to the next level. All students can access the Video Exchange library and watch each other's interactions with Paul. This library is constantly expanding and may contain the key to unlock your playing.
The pickguard, also known as the scratchplate, is usually a piece of laminated plastic or other material that protects the finish of the top of the guitar from damage due to the use of a plectrum ("pick") or fingernails. Electric guitars sometimes mount pickups and electronics on the pickguard. It is a common feature on steel-string acoustic guitars. Some performance styles that use the guitar as a percussion instrument (tapping the top or sides between notes, etc.), such as flamenco, require that a scratchplate or pickguard be fitted to nylon-string instruments.
Try one that starts with C, moves to F, then G and then back to C. This is the most basic progression, and uses the major chords you know. If you start with an A minor before going to C you can make a more interesting progression which incorporates both major and minor chords. Generally speaking, you want to focus on the chord with the same name as the key (the root), which in this case is C. Think of the other chords as either springing from it or leading back to it. Play around with the chords and see what you can come up with!
Through School of Rock's private guitar lessons and group rehearsals, children learn to play the guitar and eventually perform the songs they love in a fun, supportive and comfortable atmosphere. Based on the student's age and skill level, guitar lessons for kids are part of every School of Rock music program including Rookies, Rock 101, Performance, House Band, and AllStars.
The horizontal lines represent the frets on the guitar and the vertical lines represent the strings. The numbers listed let you know what fret number it is referring too. If there is an X it means don't play that string and if there is a 0 it means to play that string but do not press down on it anywhere. The black circles show you where to press down.
Inlays are visual elements set into the exterior surface of a guitar, both for decoration and artistic purposes and, in the case of the markings on the 3rd, 5th, 7th and 12th fret (and in higher octaves), to provide guidance to the performer about the location of frets on the instrument. The typical locations for inlay are on the fretboard, headstock, and on acoustic guitars around the soundhole, known as the rosette. Inlays range from simple plastic dots on the fretboard to intricate works of art covering the entire exterior surface of a guitar (front and back). Some guitar players have used LEDs in the fretboard to produce unique lighting effects onstage. Fretboard inlays are most commonly shaped like dots, diamond shapes, parallelograms, or large blocks in between the frets.
As you start practicing, your fingers may be sore for a while, but that will pass with four to six weeks. One thing I want to warn you about is that new guitar players can get frustrated when they can't play clean chords because they try to switch between chords too soon. Often, they try to switch chords before they've really learned and memorized each chord shape. For now, don't worry about switching chords and just work on each shape, getting them down, and going right to them.
This is a thick little book with nice big chord diagrams and shows chords in various positions. I like that it is spiral bound. The only thing missing is tabs for the letter sections so that you an easily flip to the letter note/chord you're searching for rather than having to turn a lot of pages to get to what you want. I plan to put in my own divider tabs.
At least two instruments called "guitars" were in use in Spain by 1200: the guitarra latina (Latin guitar) and the so-called guitarra morisca (Moorish guitar). The guitarra morisca had a rounded back, wide fingerboard, and several sound holes. The guitarra Latina had a single sound hole and a narrower neck. By the 14th century the qualifiers "moresca" or "morisca" and "latina" had been dropped, and these two cordophones were simply referred to as guitars.[8]
Of course, there are a few ways to narrow down the string options. For starters, since guitars come in different scales, you need a set that's the right length for your instrument. You also need to match the type of guitar: electric strings for an electric guitar, acoustic strings for acoustic. If you play an acoustic-electric, you'll usually be looking for acoustic strings since those instruments use non-magnetic pickups. For classical and Latin guitar types directly descended from ancient gut-stringed instruments, the right strings are generally going to be nylon.
The implementation of musical chords on guitars depends on the tuning. Since standard tuning is most commonly used, expositions of guitar chords emphasize the implementation of musical chords on guitars with standard tuning. The implementation of chords using particular tunings is a defining part of the literature on guitar chords, which is omitted in the abstract musical-theory of chords for all instruments.
When you get right down to it, Guitar Center's friendly instructors will do everything they can to help you reach your highest level of musical potential. And remember, guitar lessons are available for both newcomers to the instrument, as well as experienced players who want to push the limits of their performance to even greater heights. If you would like to learn more about any upcoming workshops at a Guitar Center near you, feel free to give us a shout via phone or email. Any info you need can be found on our Guitar Center Lessons homepage and we'll gladly answer any questions you may have.
Some piezo-equipped guitars use a hexaphonic pickup. "Hex" is a prefix meaning six. A hexaphonic pickup produces a separate output for each string, usually from a discrete piezoelectric or magnetic pickup for each string. This arrangement lets on-board or external electronics process the strings individually for modeling or Musical Instrument Digital Interface (MIDI) conversion. Roland makes hexaphonic pickups for guitar and bass, and a line of guitar modeling and synthesis products. Line 6's hexaphonic-equipped Variax guitars use on-board electronics to model the sound after various vintage instruments, and vary pitch on individual strings.
In an acoustic instrument, the body of the guitar is a major determinant of the overall sound quality. The guitar top, or soundboard, is a finely crafted and engineered element made of tonewoods such as spruce and red cedar. This thin piece of wood, often only 2 or 3 mm thick, is strengthened by differing types of internal bracing. Many luthiers consider the top the dominant factor in determining the sound quality. The majority of the instrument's sound is heard through the vibration of the guitar top as the energy of the vibrating strings is transferred to it. The body of an acoustic guitar has a sound hole through which sound projects. The sound hole is usually a round hole in the top of the guitar under the strings. Air inside the body vibrates as the guitar top and body is vibrated by the strings, and the response of the air cavity at different frequencies is characterized, like the rest of the guitar body, by a number of resonance modes at which it responds more strongly.
School of Rock has a finely-tuned preschoolers program called Little Wing that offers all the benefits of our beginner lessons, but is tailored to capture the attention of these young students and set them on a path towards music proficiency. Through playful exploration of rhythm, song structure, and melody kids are introduced to the guitar and other instruments.
Ernie Ball is the world's leading manufacturer of premium electric, acoustic, and classical guitar strings, bass strings, mandolin, banjo, pedal steel strings and guitar accessories. Our strings have been played on many of the best-selling albums of all time and are used by some of history's greatest musicians including Paul McCartney, Eric Clapton, Jimmy Page, Slash, The Rolling Stones, Angus Young, Eagles, Jeff Beck, Pete Townshend, Aerosmith, Metallica, and more.
Through School of Rock's private guitar lessons and group rehearsals, children learn to play the guitar and eventually perform the songs they love in a fun, supportive and comfortable atmosphere. Based on the student's age and skill level, guitar lessons for kids are part of every School of Rock music program including Rookies, Rock 101, Performance, House Band, and AllStars.
First, being able to learn directly from amazing artists like Paul Gilbert is incredible. He's a great teacher and has a way of explaining things that are easy to understand and replicate. The video format is also extraordinarily helpful; I've used other sites that use only written materials (usually .pdf format), and they are difficult to navigate. The feedback, though, is what really makes this website head and shoulders above the others (even the other video websites). When I record myself and send it in, I get a response from Paul that critiques in an incredibly constructive way as well as additional exercises to work at really honing that skill. In addition, getting to see what tips he gave to other users is awesome! If you want to learn an instrument, there's no better way.
If you are starting or just stuck in rut, this is the site for you. I had been playing three years and was not advancing as I wanted to, then I saw an ad for Paul Gilbert lessons at Artistworks. I decided to check it out and I have to say, if I had this from the beginning, I would be a much better guitarist. The main reason why, is that Paul is known for his fast playing, but he focuses you on rhythm to start off. That is were I had lacked. I thought I was a decent rhythm player, but I was not. So much thanks to Artistworks and Paul for the great site.
For the longest time I have "messed around" with my guitar. I bought a book on Jazz guitar chords many years ago and found that those fingerings were way above my skill level. I decided to get a basic chord book to reinitiate myself. This is that book. Going through these pages has re-ignited my lust to learn more about playing my guitar. One chord at a time. Simple. Skip to another key just as simple. Actually, I haven't realized how many chords I really know how to play. I just need to learn the name of those chords. This book will help with that too. Give it a try.
A slide, (neck of a bottle, knife blade or round metal or glass bar or cylinder) is used in blues and rock to create a glissando or "Hawaiian" effect. The slide is used to fret notes on the neck, instead of using the fretting hand's fingers. The characteristic use of the slide is to move up to the intended pitch by, as the name implies, sliding up the neck to the desired note. The necks of bottles were often used in blues and country music as improvised slides. Modern slides are constructed of glass, plastic, ceramic, chrome, brass or steel bars or cylinders, depending on the weight and tone desired (and the amount of money a guitarist can spend). An instrument that is played exclusively in this manner (using a metal bar) is called a steel guitar or pedal steel. Slide playing to this day is very popular in blues music and country music. Some slide players use a so-called Dobro guitar. Some performers who have become famous for playing slide are Robert Johnson, Elmore James, Ry Cooder, George Harrison, Bonnie Raitt, Derek Trucks, Warren Haynes, Duane Allman, Muddy Waters, Rory Gallagher, and George Thorogood.
The intervals between the notes of a chromatic scale are listed in a table, in which only the emboldened intervals are discussed in this article's section on fundamental chords; those intervals and other seventh-intervals are discussed in the section on intermediate chords. The unison and octave intervals have perfect consonance. Octave intervals were popularized by the jazz playing of Wes Montgomery. The perfect-fifth interval is highly consonant, which means that the successive playing of the two notes from the perfect fifth sounds harmonious.
The bass guitar (also called an "electric bass", or simply a "bass") is similar in appearance and construction to an electric guitar, but with a longer neck and scale length, and four to six strings. The four-string bass, by far the most common, is usually tuned the same as the double bass, which corresponds to pitches one octave lower than the four lowest pitched strings of a guitar (E, A, D, and G). (The bass guitar is a transposing instrument, as it is notated in bass clef an octave higher than it sounds (as is the double bass) to avoid excessive ledger lines.[jargon]) Like the electric guitar, the bass guitar has pickups and it is plugged into an amplifier and speaker for live performances.
Russell, George (2001) [1953]. "Chapter 1 The Lydian scale: The seminal source of the principal of tonal gravity". George Russell's Lydian chromatic concept of tonal organization. Volume One: The art and science of tonal gravity (Fourth (Second printing, corrected, 2008) ed.). Brookline, Massachusetts: Concept Publishing Company. pp. 1–9. ISBN 0-9703739-0-2.
A string's gauge is how thick it is. As a general rule, the thicker a string is the warmer its response will be and the more volume it will produce. However, thicker strings are also stiffer. This makes it harder to fret the string and makes it more difficult to execute heavy string bends. Thinner strings are generally brighter and easier to play, but on some instruments they can sound thin and tinny.
Do you play a warm-up exercise when you practice guitar? Guitar teacher Kirk R. shares three guitar exercises that are perfect for players at all levels... There are literally thousands of exercises and studies for the guitar. There are some that are great for beginners who are just getting used to having their fingers on the guitar, and some that are designed to challenge and grow the technique of seasoned players. But who has time to learn thousands of guitar exercises, even over man
So, what should you look for in a set of strings? There's no one answer. To go back to those same analogies: every woodwind player has a preferred strength and shape of reed, and every drummer likes a set of sticks with particular balance and tip shape. It's the same with strings: you've got different gauges and different materials to choose from, and ultimately the right ones for you are a matter of preference.
Lucky you, guitar players from all over the world, to take advantage of the tutorials presented in Justin's comprehensive website! Whatever the style you fancy, Justin is there for you with generous and precise guidance to help you enhance your playing and by doing so, introduce you to so many ways of approaching the guitar and discover new artists along the way. I wish there would have been such a medium and dedicated host around when I started to learn how to play. Bravo Justin, and my gratitude for bringing music to the heart and ears of many!
On almost all modern electric guitars, the bridge has saddles that are adjustable for each string so that intonation stays correct up and down the neck. If the open string is in tune, but sharp or flat when frets are pressed, the bridge saddle position can be adjusted with a screwdriver or hex key to remedy the problem. In general, flat notes are corrected by moving the saddle forward and sharp notes by moving it backwards. On an instrument correctly adjusted for intonation, the actual length of each string from the nut to the bridge saddle is slightly, but measurably longer than the scale length of the instrument. This additional length is called compensation, which flattens all notes a bit to compensate for the sharping of all fretted notes caused by stretching the string during fretting.
As you start practicing, your fingers may be sore for a while, but that will pass with four to six weeks. One thing I want to warn you about is that new guitar players can get frustrated when they can't play clean chords because they try to switch between chords too soon. Often, they try to switch chords before they've really learned and memorized each chord shape. For now, don't worry about switching chords and just work on each shape, getting them down, and going right to them.
As stated above, construction has just as much of an impact on a guitar's tone as material. The factors that make up construction are as follows: gauge, string core, winding type, and string coating. And while these factors are all important, keep in mind that different companies use different approaches to all of them. So never be afraid to try out a variety brands, because while the strings may look the same you will get a different response.
For experienced players, you already know what kind of questions need to be brought up when purchasing a guitar. For beginners, a great starting point is to look at what your favorite guitarists play. By taking your own musical tastes into consideration, you can narrow down your choices to models that will provide the tone and sound you already know and love. But whatever you're looking for, you can be certain that the perfect guitar for you can easily be found, right here. Just take a look around and see for yourself.
Quartal and quintal harmonies also appear in alternate tunings. It is easier to finger the chords that are based on perfect fifths in new standard tuning than in standard tuning. New standard tuning was invented by Robert Fripp, a guitarist for King Crimson. Preferring to base chords on perfect intervals—especially octaves, fifths, and fourths—Fripp often avoids minor thirds and especially major thirds,[102] which are sharp in equal temperament tuning (in comparison to thirds in just intonation).
Once you've got your categories narrowed down, then you can start getting into the nitty-gritty differences between strings. For instance, electric guitars will give you the choice between nickel (for authentic vintage sound) and stainless steel (for maximum durability). Some string manufacturers have exotic material options with their own unique characteristics, like Ernie Ball's Slinky Cobalt strings. With so many subtle differences separating guitar strings, you owe it to yourself to browse carefully and look at all the choices on the table before making a decision.
Português: Tocar Acordes de Guitarra, Español: tocar acordes de guitarra, Deutsch: Akkorde auf der Gitarre spielen, Italiano: Suonare gli Accordi con la Chitarra, Français: jouer des accords à la guitare, Русский: играть аккорды на гитаре, 中文: 弹吉他和弦, Nederlands: Gitaarakkoorden spelen, हिन्दी: गिटार बजाएँ, Tiếng Việt: Chơi Hợp âm Ghita, ไทย: จับคอร์ดกีตาร์, 日本語: ギターでコードを弾く, العربية: عزف كوردات الجيتار
Private Guitar lessons with a certified TakeLessons teacher are customized to each and every student based on their current skill level, and goals. Beginner students get to practice basic songs, basic exercises, and basic techniques. From there, the difficulty increases in order to properly challenge and motivate intermediate and advanced level guitarists to develop greater skills, to break through their preconceived limitations, and to ultimately get more satisfaction, meaning, and even paid opportunities from the becoming a skilled guitarist.
This unique degree program combines contemporary music performance training with the rigorous study of traditional disciplines including sight-reading, music history, arranging, conducting, recording and more. The comprehensive program instructs students to demonstrate stylistic depth, creative maturity and professional competence in preparation for careers in today's music industry.


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The Little Rascals - A Family Favourites Presentation
The story begins with Spanky, who is the president of the "He-Man Woman Haters Club" with many school-aged boys from around the neighborhood as members. His best friend, Alfalfa, has been chosen as the driver for the club's prize-winning go-kart, called "The Blur", in the annual Soap Box Derby style race. However, when the announcement is made, Alfalfa is nowhere to be found. The boys catch Alfalfa in the company of Darla -- "a girl!" Alfalfa isn't like his friends because he's in love with Darla, and unfortunately threatens the very existence of their "boys only" club. The club's members try their hardest to break the two apart, eventually causing their beloved clubhouse to burn down. Darla is mistakenly led to believe Alfalfa feels ashamed of her, so she turns her attentions to Waldo, the new rich kid whose father is an oil tycoon. Further trouble ensures when their prized go-cart "The Blur" is stolen by local neighborhood bullies Butch and Woim. How can they win the big race
Travis Tedford, Bug Hall, Brittany Ashton Holmes, Kevin Jamal Woods, Zachary Mabry, Ross Bagley, Sam Saletta, Blake Jeremy Collins, Blake McIver Ewing, Jordan Blake Warkol, Courtland Mead, Juliette Brewer, Heather Karasek, Petey, Elmer, Mel Brooks, Whoopi Goldberg, Daryl Hannah, Reba McEntire, Ashley Olsen, Mary-Kate Olsen, Raven-Symoné, Lea Thompson, Donald Trump, George Wendt, Eric Edwards, John Ashker, Charles Noland, John Wesley, Joseph Ashton, Vincent Berry, Miles Marsico, E. G. Daily


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I am not giving out the recipe yet, but I am gathering names and emails of those who would be interested in it. Click on the Google Doc link below to register.
I believe I have nailed keto pasta
If it tastes half as good as it looks you might be on a winner!
It makes my inner carb addicted chubby girl squeal! Please share!
Me, please.
Me 2!
Yes Please!
Need to click on the Google Doc in Carl's post to send in your email address…
Thanks! That wasn't quite clear.
If you are not ready to give it out publicly, and for free, don't post about it.
Dear lord…yes please!
Yes - sign me up please:)
I ate pasta every day for 20 + years. Now, when I want pasta, I just make meat sauce. For me, no fake noodles are necessary. Noodles stress my stomach, spaghetti squash is OK, but I really find I don't need it.
I'd have to agree with Alexia.
Why dangle something in front of peoples faces if you have no intention of sharing it in your community forum, which has a recipe section?
What if I don't like giving out my email?
Oh, I guess i'll just be singled out
Quite disappointing to see that kind of "teasing" and " email fishing " here and from someone so reputable as you… I have no interest in your pasta recipe, my greatest achievement to date is having thoroughly adapted to live a life without carb-cravings… haven't missed pasta since July 2017! That's what this forum is really about… about encouragement not about tempting!
I will be singled out with you too then we can start a new forum called "The Ravio-less"
With you!
I think he's just excited about it and wants to share it with people but also thinks he can make some money out of it!
Yeah, no comment here, I learned my lesson.
From the Google Doc
I have been tight lipped about the recipe because I think it is SO revolutionary that I may start a company to produce it. In the meantime, if you sign up below to be notified, I will let you know if and when the recipe or a product becomes available.
So yes, a possible company/product based on the recipe, so not giving it away makes sense. Email sign-ups can be a way to gauge actual interest in the product. I don't think it's meant to be a teaser any more than a KickStarter campaign or something like that.


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Ruby Rose Fox: Supernatural Love
Please note, this event has expired.
Award-winning vocalist Ruby Rose Fox returns to Cotuit Center for the Arts on Saturday, April 20, at 7:30 PM with her new one-woman show "Supernatural Love."
Ruby Rose Fox is a cultural messenger for our turbulent modern times. Her music is as sonically compelling as it is subversive, packed with lyrics that reflect and challenge our current political state, from #metoo to racism to mass-shootings. Part actress, director, and writer with eight music videos under her belt, Fox combines her theatrical experience with innovative storytelling and powerhouse vocals to creative a unique multimedia experience.
The Boston-based artist sings soul-driven,View more
Ruby Rose Fox: Supernatural Love
Saturday, April 20 at 7:30pm
Tickets $32, $27 for balcony seating
Discounts: $5 for members, $2 for seniors/veterans
Contact: 508-428-0669
Email: email@example.com
4404 Falmouth Rd (Rt. 28), Cotuit, MA 02635
MORE FROM Cotuit Center for the Arts
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Jun 4 - Jun 25, 2019
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Jun 6 - Jun 30, 2019
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Jun 19 - Jul 21, 2019
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It is a quiet neighborhood perfect for students at the graduate level.
Generally, we are very pleased with the customer service by maintenance and office staff. Our only concern is related to the blanket emails regarding monthly rent. The tone of those emails is sharp, and they appear to be sent to everyone, regardless of advance payments received. Even though we pay rent weeks in advance every month, these emails prompt me to call the office to confirm receipt of rent payment. There must be a better way to remind those who are habitually late with payments without causing unnecessary concern to those who always pay early. Thank you for asking!
I've been so disappointed by all the landscaping gut that's taken place lately --- No more birds chattering in the morning. Rocks everywhere. It's starting to feel not at all like a park anymore. I realize that efficiencies must be made, but there's been a cost.
Decent quality apartments for the price, and overall managed well
After management changes in the past years, Meadow Park apartments has went from a good value community to over priced. The last two years alone the rent has raised approximately $30 each year with little improvement to the actual living spaces. Some of the "upgrades" are new rented washers and dryers (problematic card charges and faulty equipment), new doors, windows and ugly landscaping. The actual apartment is still very stuck in the seventies with old non-energy efficient appliances, heat inefficient, propensity for mold and old decor. Maintenance is usually fast to respond but are careless at times with their repairs and cleanliness. Management makes the appearance that the want to community maintained, but never dispute with individuals on the property that make this community filthy with their cigarettes and trash littering the property. Certain areas of the property are ignored on ocassion in regards to upkeep, like removing leaves and salting, which is a hazard to the residents. The gym is hardly restocked with the proper cleaning supplies to keep the area sanitary and the common areas are filthy (laundry areas dirty with animal fur, incidents with feces on the floor from residents that also bring their animals all over without a leash and trash in the appliances). The community has discontinued incentives from previous years like recycling and young professional discounts. It is a nicer area in Bloomington to live location wise, but it is a shame that it is no longer a good value like it used to be.
Meadow Park located in peaceful, park-like surroundings will welcome you home each and every day. The serene swimming pool with sundeck, 24-Hour fitness center and our fun community clubhouse are all brought together to spoil you rotten. We are pet-friendly and conveniently located on the East side of Bloomington on popular bus lines, close to local and chain restaurants, The College Mall and Indiana University.
Application Fee: $30


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Archives: Events
Events for June 6, 2019
Events for June 6, 2019
5:00 pm
Amherst Arts Night Plus is a free cultural event held in and around downtown Amherst, MA. Each first Thursday of every month, from 5-8PM, participating venues host gallery openings, concerts, lectures, and other creative events. For a listing of current shows, please visit this link. For more information on venues, click here.Find out more »
A new Farmers' Market is coming to Amherst. The Strong House Artisan and Farmers' Market will be held on Thursday evenings, from 5 until 8. Come check out locally made arts/crafts and fresh, local produce!Find out more »
Join us during Amherst Arts Night Plus on June 6, 2019 for our monthly Open Mic. Poets, writers, and performers of any kind are welcome! Come early to view the pop-up, contemporary art exhibition in the Homestead by our featured artist, Kandy Vermeer Phillips. The open mic begins at 6:00 p.m. and will be followed...Find out more »


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Where is the Greek word for 'hell' in the Bible?
Some believe the 3 Greek words translated to English as 'hell' are actually an interpolation - that is something added to or altering/corrupting with something foreign which in this case is an 'idea' of men. Be that as it may, there are 3 words translated as hell from the Greek. They are:
Hades - meaning unseen or grave or pit and is equivalent to 'sheol' in Hebrew.
Gehenna - valley of Hinnom and a burning city garbage dump.
Tartaroo/tartarus - a dark place of restraint for the fallen angels used one time in the Bible.
See link below
Is Sparta or Spartans mentioned in the bible?
No it does not it does have the greek word "hades" meaning hell though. Read More
How do you say the word Bible in Greek?
bible Read More
How many times is hell in the Bible?
The word "hell" is in the King James Version of the Bible 54 times. It is in 54 verses. Read More
Who in the Bible is in hell?
The most common word in the Hebrew, 'sheol' and in the Greek with the same meaning, 'hades' translates in the English as 'grave or pit.' It is all humanities final physical waiting spot. So, all who died are in 'hell. Read More
How many times is hell used in the King James version of the Bible?
The word hell appears in 54 verses of the KJV bible. Read More
How many references to hell in the bible?
The word "hell" is used 55 times in the King James Version of the Bible. "Tophet," another word used for hell, is used 9 times in the KJV. The words "gehenna" and "sheol" are used in some other versions of the Bible to refer to hell, but are not used in the KJV. Read More
How many times are the words damn and hell used in the bible?
The words damn are not used in the Bible; the words damnation and damned are used 15 times in the Bible. The word hell is used 54 times in the New Testament. Note: The word hell does not appear anywhere in the Old Testament and there is no Hebrew word that is equivalent to the Christian concept of Hell. Read More
Which word appears more in the bible heaven or hell?
It is hell it appears 117 times. Read More
Who give the name of Bible why we called it as Bible is that in The Bible?
The word Bible is not in the Bible. It comes from the Greek word biblios, which means book. The Greek word comes from Byblos, which is the name of an ancient city in Lebanon, and which was the source of the papyrus the Greeks used. Read More
What is the greek word of Bible?
The Greek for "bible" is "Βίβλος"; pronounced vivlos. Read More
When was the word Bible first used?
in greek, the word bible means "Book"or "The Book". Read More
Where does the word Bible come from and what does the word mean?
Bible comes from the Greek word "biblia" meaning "paper or scrolls." Its origin is in the Greek word for the papyrus (pa-Pie-rus) plant that the Egyptians used to make paper. To invent the word Bible, scholars borrowed the plural Greek word "biblia" meaning scrolls, or "little books" and created the English word Bible. Read More
Which language is this word Bible derived from?
The word Bible comes from the Greek word biblos meaning 'a book.' Read More
Where does the word Bible originate?
The word Bible comes from the Greek word "biblio" or "biblos" which mean The Book. Read More
Does the Hebrew bible tell where hell is?
There is no mention of "hell" in the Hebrew Bible, nor is there any ancient Hebrew word for "hell". The concept didn't exist until the time of the earliest of Christians. Read More
Where did the word hell come from?
well hell came from the bible and from jesus and other gods and now its being used as a bad word Read More
Why do you need to believe in the Bible?
The Bible is the written word of God and gives the key to salvation from Hell. Read More
How many times is the word is used in the Bible?
Bible is not used in The Bible. It is derived from the Greek word biblos which means books. Read More
What Bible is translated word for word from the first Bible that was ever written in Greek and Hebrew?
There is no such thing as a bible that is translated word-for-word. Translations are forms of interpretation, because the words of one language, don't exactly match the words of another language. Read More
What do Jehovah's Witnesses say about hell?
They believe the "hell" mentioned in scripture to be a term for the common grave of mankind. They do not believe in a place of eternal torment for the souls of the wicked. According to the Watchtower 1st Nov 1968 p662.....In the Hebrew Scriptures of the Bible the word "hell" is translated from the Hebrew word sheol´. This word occurs 65 times in all. The King James Version of the Bible, however, translates sheol´ 31… Read More
How many times is hell mentioned in the Bible?
This would depend on the translation being used. In the oldest manuscripts available, the Hebrew word sheol appears 65 times. The King James Version translates this Hebrew word sheol, 31 times as "hell," 31 times as "grave," and 3 times as "pit." So in the "Old Testiment," the KJ version uses the word "hell" 31 times, but it interesting to note that the same Hebrew word Sheol was also translated into two other words, "grave"… Read More
What is full meaning of BIBLE?
The word bible is esseanctialy derived from the greek word biblios which means book. Read More
What is the greek word for bible?
βίβλος (biblos) Read More
Why did the Bible is named Bible?
"Biblios" is the Greek word for "book." The name "Bible" is simple a transliteration. Read More
How many times does the word PAYAM appear in the bible?
The word "payam" is not in the Bible. The word "payam" is of Islamic origin, not Hebrew or Aramaic or Greek, in which the Bible was written. Read More
What does the word hades mean in the Bible?
Hades is a Greek term meaning 'grave or pit.' Unfortunately, many verses translate this in the English as 'hell' which has confused many. It is the equivalent to the Hebrew term 'sheol.' Read More
Who suggested the name Bible?
Bible is derived from "biblos," the Greek word for book. Read More
How did the Bible get its name Bible?
it came from the Greek word "Biblos" which means book Read More
When was The Bible first named The Bible?
The word "Bible" comes from the Greek word for "book", biblos (also biblion) which is originally derived from the name of the Phoenician city of Byblos. This city seems to have been known as a center for books. The word "bible" therefore simply means "book", in Greek. Read More
How many times do the word hell appears in the book of st john?
In the "Gospel according to Saint John"" the word Hell does not appear in the KJV or the NKJV of the bible. Read More
How may times does hell appear in the bible?
In the King James version the word - hell - appears 54 times Read More
Greek word in bible for passion?
πάθος (pathos) Read More
Uses allusions to the Bible and Greek mythology?
In many religious traditions as well as the Greek mythology, Hell is a place of suffering and punishment in the afterlife, often in the underworld. Read More
What does the spelling of Bible stand for?
The ancient Greek word "biblos" or "byblos" translates as the word "book". So the bible is "THE" book. Read More
Where did the Christian Bible come from?
The Cristian Bible came from the word Biblia this means Bible in greek. Read More
What was copied from the Hebrew Bible to the Greek Bible?
The HOLY BIBLE, in its entirety, is complete and copied, and it is the true word of GOD. Read More
What is the origin of the word Bible?
From the ancient Greek word, biblion, meaning "book." Read More
What ancient greek word mean hell?
Hades, the underworld, land of the dead. Read More
What is the Greek translation for the word hope in the Bible?
elpizo, elpida Read More
What was one of the things hades had on modern day?
In the Bible Hades is another word for "Hell". Read More
How many times is the word hell used in the King James Bible?
54 times. Read More
How many bible verses contain the word hell?
54 verses in the KJV, in many modern translations it's sheol in the Old Testament and hades in the New Testament which are transliteration of the original words in Hebrew and Greek and not translation. Read More
Is there a Bible for hell?
The Bible isn't for any specific place, and no metaphorical "bible" exists for Hell. Read More
What does the word bible actually mean?
The word Bible is of Greek origin from the phrase, ta biblia, meaning, 'the books'.> Read More
What is the greek word for hell?
Hades, or more correctly the domain of Hades the god of the underworld Read More
Why do Christians believe in heven and hell?
The Holy Bible was inspired by God. Christians believe the Bible is God's Word. In the Bible we are told that there is an Heaven and a Hell. Christians believe that people who accept Jesus Christ as their personal Savior will eventually go to heaven. People who do not believe in Jesus Christ will eventually go to hell. God has told us of heaven and hell and we believe what He says. Read More
What religions do not believe in a hell?
ANSWER I will start this discussion by mentioning that Jehovah's Witnesses do not believe in a burning hell. I emphasize the word burning because we believe in what the Bible calls, hell, sheol, or hades. We accept the explanation the Bible gives for hell, not the common one found in many religions. One such scripture is at Ecclesiastes 9:5,10, where it says, "For the living are conscious that they will die; but as for the… Read More
Where did the Bible get its name?
Greek Biblos means a book. As greek was popular language then, and people used to refer to the books somewhat like 'This is written in the book of ....", bible could have become popular word for The Bible. Read More


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Mila Kunis
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Welcome to the Servicing Master BlogYou can find interesting and informative articles posted here on a regular basis.
Eight Car Smells That Should Be Promptly Checked
Car problems rarely happen without warning. Usually, there are symptoms to warn you about problems before a major breakdown occurs. A strange smell is one of them. Any unusual smell should be checked and fixed promptly because it can be a sign of a health hazard or an...read more
How To Avoid Belt And Hose Failures
If you look into the engine compartment of your car, you will notice several belts and hoses. They are critical for correct engine function. Any belt or hose failure is a serious issue and can result in a major breakdown.Belt and hose failures sometimes come with...read more
Why Do Car Makers Recommend A Service Every 6 Months?
Most car makers specify a periodic service every six months for cars with average use. The service intervals are specified both in terms of time and mileage. The next service becomes due when the specified number of miles are completed or the specified time has...read more
How To Keep Your Car Clean And Hygienic
A cluttered car with stained seats, food crumbs, trash and musty odour is hardly an inviting place. With our daily commutes, errands, shopping and those weekly outings, we are spending a lot of time in our vehicles. If we are spending so much time in a small space, it...read more
10 Tips To Save Money On Fuel
Fuel is the most obvious running cost of your vehicle. Fuel efficiency may not matter much if your car is used sparingly. But, if you travel a lot, saving fuel will make a significant difference to your wallet. Here are some tried and tested methods to reduce fuel...read more
Should I Get My Car Checked After Driving Through Water?
In the UK, you cannot rule out the possibility of flooded roads at any time of year. Flash floods or persistant rain can cause road flooding. Cars are not designed to go for a swim. So, avoid driving through a flooded section of the road. Besides being dangerous, it...read more
Can Potholes Damage My Car?
With winter on its way out, the conditions are ripe for pothole formation. Fortunately, most pothole hits don't cause any major damage. That said, a severe impact can result in a trip to the garage. Potholes can't be wished away, but you can minimise the risk to your...read more


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Elizabeth Andrade Hawaii
Elizabeth Andrade could be living in Kaneohe, Hilo, Mountain View or 1 other places in Hawaii.View Records
Elizabeth L Andrade
Age 95 years old
Gender Female
Lived in Kaneohe, HI
Phone (808) 247-3000
Elizabeth Andrade
Age 36 years old
Gender Female
Lived in Palmdale, Lancaster, and Baldwin Park, CA.
Email la****@h****.com
Possible User Ids 22****@hi5, 10****@facebook
Phone (503) 875-8000, (626) 890-6918, (661) 916-6815, (661) 526-5000, (661) 533-1000
Possible Associates Elizabeth Andrade could have been associated with Nancy Castro, Juan Manuel Lopez, Martyna Smith, and Kyt Kaline.
Elizabeth F Andrade
Age 55 years old
Gender Female
Lived in Hilo, Mountain View, and Honolulu, HI.
Email ed****@h****.com
Phone (808) 557-7630, (808) 968-1000
Elizabeth E Andrade
Age 99 years old
Gender Female
Lived in Houston, Spring, and Conroe, TX.
Possible User Ids 10****@facebook
Elizabeth F Andrade
Age 28 years old
Gender Male
Lived in Hilo, HI
West Palm Beach, Fort Pierce, Fort Myers, and Coconut Creek, FL.
Oak Harbor, WA
Medford, OR
Flint, MI
Colorado Springs, CO
Email ed****@m****.com
Possible User Ids 33****@linkedin, 94****@linkedin, #3****@linkedin
Phone (561) 745-3275, (509) 640-4000, (719) 434-1549, (808) 557-7630
Possible Associates Elizabeth F Andrade could have been associated with Julie A Bethea, Antonio M Deandrade, and Julie Oliveira Magalha De Andrade.


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Family Physician
Exp 50 years
I will be looking into your question and guiding you through the process. Please write your question below.
1 Doctor agrees with this answer
diagnosed as reactive (1-16) to valley fever. office just called to tell me to reduce dosage to 200 mg per day. pharnacy just called to tell me that long time use of simbastatin may be issue and waiting for dr retrun call. just recovered from pnuemonia on left lobe. little confused and dr nurse could not tell me how severe VF is on me.no signs like rash or cough. help!!
I have a severe cough and fever on Jan first week of this year, then I visited doctor and he gave me four days of medicine. my cough got reduced after four days. but what my problem is i have dry cough daily throughout the day until today. what can i do. why i have this cough. your comments will appreciate.
Hi, I m a 27 year old man and early this morning, after only a few hours of sleep, I suddenly woke up feeling unable to breath properly, as if something was blocking my throat. In an effort to breathe I was doing this weird cough-like function, like 10 times, which didn t change the situation. I felt that only minimal or no air at all was allowed in. I had a bottle of water near me so I drank some and after that I was able to breathe better, though I don t know if that s what helped me. However I was somewhat scared since this has never happened to me before, so I went to the ER. There, the doctor did a few basic tests, heard my breathing, checked my throat, took my blood pressure and a blood sample for blood tests, mostly to see the oxygen levels, as well as a chest area x-ray, and asked me the usual questions, like if I ve been sick and taking any medication, which are both negative. He also asked me if I felt anything weird still and I said my throat was sore though it may have been just because of the effort it took to breathe earlier. The doctor found everything normal, my blood pressure was surprisingly good too since I usually have a little bit hypertension, so he sent me home and I was frankly relieved, though I didn t feel like going back to sleep, in the end I fell asleep. It has now been 5 hours since the incident, and my throat still feels sore and weird, perhaps more so than previously, so I m worried the episode will happen again. Other information the doctor asked me, in case you need it too, is if I smoke, which I don t personally though I live with chain smokers so the house is often full of smoke, if I have any known allergies, which I don t, to my knowledge, as I only remember having an episode like 10 years ago but we never figured out what it was that I reacted badly to, with rashes and itch all over my body at the time, and it has never happened since. Anyway, I also feel like I may be coming down with a fever now, though the doctor took my temperature as well and while I didn t ask how it was he didn t mention anything about it. So, what could this be, waking up unable to breathe, and still feeling sore after 5 hours despite the ER doctor finding everythingi n order?


text:
docplex provides warnings when you create decision variables with duplicate names:
x = m.continuous_var_list([1,2], name='x')
y = m.continuous_var_list([1,2], name='x')
This produces a warning:
Warning: Duplicate variable name: x_1 already used for x_1
Warning: Duplicate variable name: x_2 already used for x_2
But when you create duplicate constraints, you get no warning:
m.add_constraints([(x[0]+x[1]<=2, 'c1'), (x[0] + x[1] >= 1, 'c1')] )
Getting these warnings is useful, as it can help you figure out if something is wrong with your model. Is this not checked by default, or a feature that could be added?
-Irv Lustig
Princeton Consultants
Answer by DanielJunglas (2376) | May 21 at 01:37 PM
Duplicate of https://developer.ibm.com/answers/questions/505451/duplicate-constraint-names-not-detected-in-docplex.html
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Emory J. Bezila
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Emory J. Bezila
84, Johnstown, passed away May 16, 2019 at Cambria Care Center. Born March 28, 1935 in Johnstown, son of Emory J. Sr. and Susan (Pazin) Bezila. Preceded in death by parents. Survived by companion, Shirley M. Bezila; daughter, Connie Kralik and son, Terry Bezila, all of Johnstown; and grandson, Justin Kralik, Philadelphia, PA. A brother of Dorothy Hampton, Johnstown; and Robert J. Bezila and wife Lucy, Connecticut. Also survived by nieces and nephews. A veteran of the PA National Guard. Retired Steel Worker for Bethlehem Steel and FreightCar America Johnstown. At the request of the deceased, there will be no public services. Arrangements by Francis G. Ozog Funeral Home, Inc., Broad Street. Private committal. Condolences may be sent at fgozogfuneralhome.com
Published on May 17, 2019
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So sorry Connie take care and God Bless you and your family


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Poplar Farmhouse
Staffordshire Stafford District Stafford
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Pretty village. Originally a working dairy farm, this turn of the century detached farmhouse has been carefull...
Sleeps 14
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The Hayloft
Worcestershire Worcester District Worcester
Situated in a quiet location yet just minutes from Kidderminster, it is a perfect base for exploring Ludlow, Worcester and Telford.
Set along a quiet, rough track but just a few minutes' drive from Kidderminster, S24897 is conveniently...
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Lavender Lea
Warwickshire Stratford-on-Avon District Alcester
S97624 is located on the outskirts of Henley-in-Arden with its unspoilt historic high street, and is ideal for exploring Shakespeare country.
Set in the magnificent Warwickshire countryside, less than 1 mile from the centre of the attractive...
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The Old Stables
Enjoy the cosy log burner, walks from the doorstep and conveniently situated near to many attractions including Alton Towers.
Peaceful hamlet setting. This lovely barn conversion is ideally situated in a quiet Staffordshire hamlet, yet is wi...
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Bridge House
Derbyshire South Derbyshire District Overseal
S16876 is an attractive property with a four poster bed, electric woodburner and a hot tub.
Superbly presented, beautifully furnished and professionally managed, this attractive cottage in the National Forest, stands in an acre of private en...
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Chatcull Old Hall
In a rural location boasting a superb inglenook fireplace, perfect for exploring the natural wonders of the Peak District.
Set in delightful, unspoilt countryside, S16061 is an attractive and spacious farmhouse that dates back 300 years and ...
Sleeps 12
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The Hayloft - 18937
Staffordshire Staffordshire Moorlands Leek
Peacefully situated with riding, cycling and walks locally, yet within easy reach of Alton Towers.
Peacefully situated surrounded by open countryside and fields on the owners non working farm (although there are a few chickens) these two bar...
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Piano Barn
Staffordshire Stafford District Stafford
Located in a quiet village with many walking and cycling opportunities, as well as being within walking distance of the pub.
5 bedrooms / 4 bathrooms. This super detached home has been created from a 150 year old former barn, more recently ...
Sleeps 14
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Cornfield View - UKC3892
Staffordshire Stafford District Stafford
Cornfield View is perfect for families and groups wishing to explore nearby Tamworth and National Trust properties of Calke Abbey and the Shugborough Estate.
These two barn conversions, Cornfield View (ref UKC3892) and Woodland View (ref UKC...
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Dale Cottage
Shropshire Bridgnorth
Just a short walk from the River Severn and the centre of Ironbridge, with museums and craft shops, Much Wenlock is nearby.
Situated on the edge of Coalbrookdale, just a short walk from the River Severn and the centre of Ironbridge, this att...
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The Stables - 18936
Staffordshire Staffordshire Moorlands Leek
An ideal area for Alton Towers and for exploring the great outdoors in the Southern Peak District and Staffordshire Moorlands.
Peacefully situated surrounded by open countryside and fields on the owners non working farm (although there are a...
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Fenn House
Warwickshire Stratford-on-Avon District Alcester
An ideal touring base for all ages and within easy driving distance to explore Shakespeare country.
Situated in the beautiful village of Alvechurch that lies in the valley of the River Arrow, S15908 is the perfect location for guests wishing...
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Aspley Cartshed
Staffordshire Stafford District Eccleshall Slindon
Ideal for a family or group of friends wishing to explore Staffordshire and the Peak District.
Offering beautiful far reaching countryside views over magnificent Staffordshire countryside, S128417 can be found in a true rural location on the...
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Shropshire Market Drayton
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Brook Cottage
Telford and Wrekin Lawley and Overdale Telford
S2673 is a semi-detached 19th century cottage in the Shropshire village of Coalbrookdale near to Ironbridge. The cottage sleeps six people and has a double bedroom, family bedroom and a single with an en-suite as well as a family bathroom. Also in...
Sleeps 7
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The Lodge
Shropshire Bridgnorth
S2912 is a detached property situated close to the owners' farmhouse, on a 26 acre smallholding, two miles from the village of Chelmarsh, six miles from Bridgnorth in Shropshire. This single-storey cottage sleeps five people in three bedrooms, con...
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Shropshire Shrewsbury
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Wenlock House
Shropshire Much Wenlock
Over three floors. Three bedrooms: 2 x king-size double (one with en-suite shower, basin and WC), 1 x second floor king-size double. Bathroom with bath, shower over, basin and WC. Second floor bathroom with freestanding bath, basin and WC. Ground ...
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The Hinks Barn
Telford and Wrekin Preston upon the Weald Moors
S2365 is a semi-detached brick built barn conversion set close to the owners' home in a 40 acre estate, 2.5 miles from the village of Lilleshall in Shropshire. This cottage sleeps nine people and has four bedrooms consisting of one family room wit...
Sleeps 10
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Shropshire Shrewsbury
Sleeps 7
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The Hinks Farm Cottage
Telford and Wrekin Preston upon the Weald Moors
S2568 is a quality semi-detached cottage on the owners' land near Lilleshall in Shropshire. The cottage has a ground floor room with double and single, and upstairs, another family room with double and single and an en-suite with spa bath, large s...
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Telford and Wrekin Lawley and Overdale Telford
This delightful property forms part of four cottages set alongside the Huntsman Inn, a popular family and pet friendly pub with a hikers bar and excellent restaurant. Lovingly developed to the highest of standards, t...
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Kestrel Barn
Shropshire Bridgnorth
Set next to a working farm amidst beautiful Shropshire countryside is this semi-detached barn conversion, located just four miles from the pretty market town of Bridgnorth. Decorated and furnished to a high standard, the property boasts exposed be...


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Lee Willows, Anne and Keith Evans from the charity Young Gamblers Education Trust (YGAM) gave the most passionate presentation I've ever seen at Sky Betting & Gaming (SBG). Their personal accounts of the devastating impact that problem gambling wrought on their lives were hugely moving. Turning his experience into a positive, Lee spoke of founding…
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Figure 5. A schematic diagram showing a typical affinity separation. The affinity ligand is represented by the black squares attached to the round support particles. The complementary structure of the target protein is represented by the square cavities carried by some feedstock components. Only these compounds can bind to the immobilized ligand while unwanted materials are washed through. Bound product can then be recovered in an elution step.
Because of the high degree of selectivity which is possible, affinity systems are among the most powerful separation methods available. Some are currently used on a preparative scale for the commercial purification of pharmaceutical and research products. However, there are economic and technical restrictions on the application of these methods to the purification of large-volume, low-cost products such as many of those required for food use. Many ligands are themselves biological compounds and are therefore expensive to synthesise or to purify from biomass. The specificity of the protein-ligand interaction can also be a disadvantage as method development may involve a great deal of research and development which is likely to be relevant only to a single product. Affinity chromatography will also suffer from those limitations of chromatographic methods which were discussed in the previous section, but using more expensive media with a shorter active life.
The use of group-specific ligands can help to overcome some of these problems. These ligands do not have specificity for a single enzyme, but for a group of enzymes which share areas of structural similarity. For example, cofactors such as NAD and AMP may be used to purify the many enzymes which have binding sites for these molecules (Mosbach et al, 1972; Lee, 1983). The introduction of anthraquinone dyes such as Cibacron Blue as group-specific ligands was an important development in affinity chromatography. These originated as textile dyes and are therefore available in bulk at low cost. Haeckel et al (1968) observed by chance that Cibacron blue bound to pyruvate kinase during gel filtration. It has since been used as an affinity ligand for the purification of a wide range of enzymes (Clonis, 1987). The specificity is therefore not absolute but this is off-set by the wide range of potential applications, and the commercial availability of bulk volumes of pre-prepared separation media. Dye-ligand chromatography is the most widely used form of affinity chromatography on a large scale (Jones, 1991). Sea wen & Atkinson (1987) listed 228 examples of dye-ligand chromatography published between 1980 and 1987. Of these over 40% described the purification of oxidoreductase enzymes such as alcohol dehydrogenase and malate dehydrogenase, and over 50% used Cibacron Blue as affinity ligand.
The techniques of molecular modelling have been used to establish that Cibacron Blue binds to the NAD binding site of horse liver alcohol dehydrogenase (Biellmann et al, 1979). This has enabled the synthesis of dye analogues with improved binding (Lowe et al, 1992). The ligand can thus be "tailor made" to fit the target enzyme. Group-specific ligands can thus be used as a starting point for the development of a series of ligands of higher selectivity. The rational design of affinity agents, either de novo or as analogues of established ligands, will certainly be aided by knowledge of the structure of binding domains in enzymes. Various techniques are now available for the determination of 3-dimensional molecular structures and these are being applied to the modelling of molecular interactions in food research (Kumosinski et al, 1991). As many of the enzymes involved in food technology share common functions (Table 1), they may make good subjects for the rational design of low cost ligands which can be synthesised on a large scale.
An alternative means of achieving selectivity in bioseparations is molecular imprinting. This involves the synthesis of polymer matrices which incorporate an intrinsic affinity for the species to be adsorbed. This is achieved by carrying out the polymerisation reaction in the presence of the target molecule which acts as a template around which the polymer is formed.
Interactions between monomer functional groups and the template molecules cause the resulting polymer to form in a conformation which is complementary to the template structure. Subsequent removal of the template molecule leaves cavities in the polymer matrix which are capable of specifically adsorbing the target species from solution (Wulff, 1993). This procedure is illustrated in Figure 6. The attraction of molecular imprinting is that separation matrices can be synthesised which incorporate the desired affinity in a stable form, and that specific adsorbents can be obtained for molecules for which no complementary ligands exist. This method has been investigated for the resolution of optical isomers of sugars (Wulff & Schauhoff, 1991) and amino acids (Ekberg & Mosbach, 1989).


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Protocol. Rabbit received two injections of mg. of uranium
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referred more especially to the fibrous attachments of the affected
Protocol. Rabbit received two injections of mg. of uranium