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{{incomplete|2=English logo, images, Famitsu Cup rules, rankings, everything with a question mark}}
[[File:Global Battle Union Japanese logo.png|thumb|Japanese Global Battle Union logo]]
The '''Global Battle Union''' (Japanese: '''グローバルバトルユニオン''' ''Global Battle Union''), commonly shortened to '''GBU''', is a part of the [[Pokémon Global Link]] that displays battle records from the Random Matchup Rating Mode in {{game|Black and White|s}}.<!--It started in August 2011.-->
In order to access the Global Battle Union, a player must have a Pokémon Global Link account. Rankings cannot even be seen without logging on to the site first.
[[File:Red Trophy select.png|thumb|Selecting
an avatar]]
Every season, once a player has completed ten Random Matchup [[Nintendo Wi-Fi Connection|Wi-Fi]] {{pkmn|battle}}s (ties and incomplete battles do not count) of any format, they are added into the rating system of the Global Battle Union. All players are rated according to the number of points that they have. The points are generally intended to account for the win-loss record of that player.
In Rating mode, players must follow a certain set of rules. Players who choose Free mode have the option to make use of these rules. The rules are subject to changes caused by the likes of glitches, world championships, overall balance, and unreleased Pokémon. For example, as mentioned in the games, the initial list of banned Pokémon only included the following: [[Pokémon Egg]]s, {{p|Mewtwo}}, {{p|Mew}}, {{p|Lugia}}, {{p|Ho-Oh}}, {{p|Celebi}}, {{p|Rayquaza}}, {{p|Jirachi}}, {{p|Deoxys}}, {{p|Chatot}}, <!--NO Dialga-->{{p|Palkia}}, {{p|Giratina}}, {{p|Phione}}, {{p|Manaphy}}, {{p|Darkrai}}, {{p|Shaymin}}, {{p|Arceus}}, {{p|Victini}}, {{p|Reshiram}}, {{p|Zekrom}}, and {{p|Kyurem}}. The list of course excluded {{p|Keldeo}}, {{p|Meloetta}}, and {{p|Genesect}} as they were yet to be released. If a player has Pokémon Black and White Version 2, Therian Formes of
Thunderus, Tornadus and Landurus are also not allowed since they can't be obtained in the Pokémon Black and White Version.
{{GBU|all|Random Matchup|randommatchup=yes|
To date, the Battle Union has hosted the following competitions:


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It seems that some users are having issues with their IP being blocked for no reason.
The issue should now be resolved.
Description : Nice one reallt.....the track has a sad beat
Review,listen and enjoy
PS;and when someone wana rap o this beat just mesege me!!
ROCKY PRODUCTion
So far 6 users have left a comment on this track.
If this is your track why not return the love and check out their tracks too.
hey cuz i got so mutch i could lay to this so fast if you still on here shoot it to my e-mail and ill jump on it n get it mastered n back to hya tha same day.
ill spit on this.
send me a copy
this is a chilly cool track man needed to be listened at during sunset. and that is where i am doing now. like the others, i think u can lay some wise words on this one. would be perfect.
keep bringing them like this
Sad trak true but I found it very melodic and soothing until the gunfire brought me back to the direction of the trak. Nice job here Rocky.
ey ssup man i would love to rap on this beat...
I like this...has a nice miss you vibe for anybody who lost someone to a shooting...i can relate to that feeling...nice sad joint!!!
Description : pretty cool track
first of that genre as i am more of a rock type of person
6/10/07 - Thanks guys for making this the top downloaded track on looperman as of today. I appreciate it. I plan to get more tracks up soon so stay tuned!
Description : 32 bars I put together after i got amped off the beat. Beat made by "J1k."
Description : .
Services I offer:
-Recording, Mixing and Mastering
-Feature verses for beatmakers
-Feature verses for artists
-Writing, Delivery and Song Creation Course (Skype/phone)
Message me for details
Description : hip hop track made wit FL studio's
Description : This song is all about SJW and his talent. I just added my verse.
Description : really tried played dat piano to ma best in this one I luv the simplicit bubt alltough its real deep I luv how the piano leads throug the whole song I hope u all enjoy the track, if I get good reviews I might upload the samples as loops too track BPM is 90 make it downloadble. cheerz ya boy dusthill
Description : Messing around in the studio doing what i love to do. Getting some practice with record, mix, master. What you guys think?
Description : hello guys/women,i just wanna mention that your all welcome to follow me on instagram.i give advice and speak my mind in order to help others and myself.the topics vary time to time but yeeeh you can check it out if u wanna:) the purpose is to spread knowledge and wisdom,feels good to help others.
here is the link and am sorry if this post disturbs u but yeeeh what can i say? take it or leave it:
Description : jep theres news from ya boy dusthill didn't go to work today had a few drinks too much yesterday anyway so I started a new Instrumental more hip-hop boosty bass kicks this time but still bein true bout ma love to the orchester. hope you like gonna upload the loops too I think. Enjoy and gimme some reviews pleaaseee ^^ cheerz da swizzy
Description : This is The LasT of 3 SP Edition of The ConsPiracy ...! Made on MixCraT 8 Pro...! Hope you enjoy & Keep on PLAY!!!
Description : Hip Hop track made wit FL Studio's
Description : This Is Just A Snippet Of My Song "When I'm Gone" Which Is A Reality Check For My Brothers And Sisters In The World. The World Is In A Bad State Right Now And We Need To Join Together To Restore Some Peace And Integrity. Vanity & Self Love Is A Start For Each Individual And Joining Together Afterwards Can Heal The Wounds We Put on The World. Like, Comment, Download As You Please.
Description : This is a song made by my mate, and Produced by The Real Triggz on Soundcloud. Really cool song! Please leave feedback and share! Check out his Soundcloud page: https://soundcloud.com/user-112820814/bxnner-blem-remix
This is his first studio recording song!
Description : Boombap is the dream genre.
Description : i never do this type of thing, but I felt i had to
it's a diss on macklemore and a couple of others
beat is by jsnell
lyrics by Progress

subset: commoncrawl


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Outdoor Furniture in Petaluma
Here you will find accurate info on various businesses belonging to the Outdoor Furniture category in Petaluma. From the latest category entries up to a list of similar categories in this area. Feel free to 'dig in' and get the data that you are looking for.
Request for Quotation
Are you looking for Outdoor Furniture ?
Use our 'Request for Quotation' service and get customized offers from companies in Petaluma.
Most popular searches in Petaluma in the "Outdoor Furniture" business category
Latest entries in Petaluma in the "Outdoor Furniture" business category
- Kirkland's401 Kenilworth Drive- 94952Opening Hours


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Information Links
Local Plans
Track English councils' progress in adopting local plans and view the latest data on our interactive map, including the latest updates on local plan coverage from the Planning Inspectorate.
Try our new database of local plan inspection documents click here.
Page Title RSS feeSign up for our new Local Plan Watch email bulletin.Page Title RSS feed
Maps: core strategy progress data
Use our new interactive map to view English councils' progress in adopting local plans and view a spreadsheet containing the latest data on local plan coverage from the Planning Inspectorate.
Local Plans News
Inspectors warn Uttlesford residents' group administration of local plan withdrawal
An Essex council has been warned by planning inspectors that its local plan may have to be withdrawn from examination after political control of the authority passed to a residents' group that has previously claimed the submitted strategy is unsound.
York consults on cutting housing target in proposed local plan changes
A North Yorkshire council is consulting on a raft of proposed amendments to its submitted local plan, including a cut in its annual housing target by nine per cent from 867 homes per year to 790.
Northumberland submits plan with 40% fewer homes than earlier version
Northumberland County Council has submitted a local plan for examination this week which proposes more new homes than the local housing need figure says are needed, but fewer than a previous version of the plan proposed.
Guildford local plan faces prospect of judicial review over green belt allocations
Controversy over the recently adopted Guildford local plan is mounting after three judicial review applications were submitted and a local MP renewed his calls for the document to be subject to an early review.
Local Plan Updates
Nuneaton and Bedworth Local Plan - Strategy adopted
Chiltern and South Bucks Joint Local Plan - Strategy published
Rugby Local Plan - Strategy adopted
Barrow-in-Furness Local Plan - Strategy adopted
Northumberland National Park Local Plan - Strategy published
Northumberland Local Plan - Strategy submitted to Secretary of State
Stevenage Local Plan - Strategy adopted
Huntingdonshire Local Plan - Strategy adopted
Northampton Local Plan - Strategy published
Guildford Local Plan - Strategy adopted
- Strategic Projects Manager (Planning Delivery) upto £54,656 Lewis Davey Shefford, Bedfordshire
- P/T Senior Planning Officer (Minerals & Waste) Lewis Davey Shefford, Bedfordshire, Flex Working
- Chartered Planner - Leeds (Senior or Associate) Lewis Davey West Yorkshire
- Planning Director - London Lewis Davey London (Central), London (Greater)
- Chartered Planners - Leicester Lewis Davey Leicestershire
Local Plans In Depth
Local Plan Watch: Merged councils begin local plan reviews
Council mergers in Dorset, Suffolk and Somerset have sparked work to produce a series of new unified local plans. Local government reorganisation in Dorset earlier this year saw nine councils become two new unitary authorities.
What the rise of local political parties opposing housing plans means for applicants and authorities
Despite overt opposition to emerging and adopted local plans, residents groups that have emerged as key players in three councils in the wider south east may find it difficult to dramatically revise local development strategies, Planning has discovered.
What the local election results mean for planning
Changes in administrations at eight key councils following last week's local elections are likely to impact on planning and development, say commentators.
Is Wirral Council finally getting serious about plan-making?
Faced with the threat of government intervention, Wirral Council has published its action plan for improving its tardy plan-making. The plan shows no evidence of willingness to review the green belt, and reveals that the council's plan production timetable has slipped again. But it also discloses significant recruitment of officers and advisers, and a pledge to meet housing need as calculated by the government's standard method.


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2,036 comments
yes, some early tii's had 10:1 compression, @2002Drew; but the '74's ran identical bottom ends to normally-aspirated '02's.
That misalignment, @chrisawolff, is a very easy fix — about 15 minutes fiddling with the hood adjustments will fix it. Mystified why the owner hasn't seen to that.
Either that, or he forgot to latch the hood between photos! (been there, done that…)
Y'know, just when I think I've seen every car EVER here on BaT, along comes something like this that I've never even heard of. A thing of beauty! GLWTA
hey @bentleyboy29, you'd better paint it red, because for what you paid, it's a hot car ;^)/ a steal at this price. I'd'a thought closer to 9K even with the rusty bits…
As for the rear shock bolts, @kevlac, my '99 (RIP thanks to a blind driver that turned in front of me) came with one of the bolt holes cross-threaded from the factory. Apparently there were quite a few, from what I was told by the dealer; I guess either someone got lazy, or the programming on one of the robots had a glitch…
I agree with @Markos — the "red interior lover" was not in the house…
When I first saw this listing, my initial reaction was "nice Baikal; nice red interior; but the two together?? ==gag== ". I suppose it could grow on you, but this is indeed a, er, "unique combination".
@WAGONBOYTD, I'm one guy who sure as hell would NOT want my first car back, even though it got me through school dependably. A '62 Buick Special. Did not attract hot chicks (not that I did, either…). But my 2nd car, a '69 BMW 1600-2, put me on the path of righteousness, and I currently have three 02's.
Now if I could just afford to buy that E9 that Mike is selling here on BaT…
I too have seen this CS in person, and can echo the previous sentiments as to its condition and care from Mike. I'd love to own this beautiful beastie (I think the 5-spd conversion perfected the car!) but this one will go way past 3X the current bid…so about 5X beyond my wallet's capabilities ;^)/ Best of luck with the auction, Mike!
I'm gonna go out on a limb and guess that the day of the week may have had something to do with the dearth of good bidders. I've been on this site for about 6 years now, and it always seems that mid-week is weak (pun not intended) for some reason; end an auction on a Friday or a Saturday, and there appears to be more action. Maybe it's because that thing we all have to deal with called "work" gets in the way of important stuff like buying a cool car on BaT…
Nice to hear that the buyer and high bidder were able to find common ground, er, finances; this is one of the great features of BaT, that there is a portal for after-the-fact if it runs RNM.
And I agree with Delia: that this particular car is not for the "discerning" collector, but rather for someone who knows what's there and is looking to drive the snot out of the thing!
Wow…nice catch! "Bidder3028" (nice and cryptic, I like it!) is gonna be havin' some funnnn drives in this killer little 02. I'm suitably jealous. ;^)/
I'd disagree,@montanabahn — the owner mentioned early on his displeasure with the welding; but that doesn't mean that anything else on the car is wanky — to me the car looks pretty decent. Like @PDXBryan commented, it looks well worth it.
FWIW, my '01 has clocked 212K with no issues (knocking on wood as I type this…). Maybe because it's a 5-speed and I never "lug" it.
What's wrong with the flares? Personally, I think it gives the car some extra panache, something beyond the brown-box look. But I will add that this poor beastie is crying, nay, SCREAMING to get rid of that fugly junk-in-the-trunk (pun intended) look of having the diving board remain on the back. Criminy, I'd likely put a nicely-finished 2×6 on it before I'd leave that p.o.s. on there…
And BaT, once and for all, the word is "flares", not "flairs" — flair is synonymous with style or exceptionable ability, as opposed to something spreading outward. (Sorry, this has always bugged me to no end…along with people who "did a break job" on the brakes. Yes, I'm being somewhat pedantic, with no apology…).
The most perfect CS I've seen in a loooong time. All the Right Stuff (5-spd, etc).
Another case of resentment that I was not born rich… ;^)/
Agreed, @CoupeKing; I think Jeff (IE) discovered that the straight bars had oil pan interference issues on some cars, thus the "dip"…
drool, drool, d-d-d-drool… Now THIS is what a hotrodded 02 is all about. Nicely done, DV — if I didn't already have my own version of this beastie, I'd be all over this one. All the Right Stuff (okay, mostly — to each his own taste!) and for someone who wants a Bavarian sleeper-killer without having to pay ///M dollars, this is Da $#!t
GLWTA, it's gonna bring some good money IMHO.
Just to elaborate to you in case you don't know, @artreality (great handle, btw), there is a VERY strong E30 M3 community in this country (actually, it's now worldwide) and several of the commenters on this listing (Jimmy_P and myself included) are members of this SIG. It has been unofficially regarded as the definitive source of E30 M3 lore for the almost eight years that I've been a member, and I personally have learned at least half of my knowledge of these cars via folks like @Jimmy_P and @Mangler et al. For every person that thinks someone who has never sold or bought a car on BaT is not credible, I'd bet there are probably ten who appreciate the sharing of knowledge on the site by people such as these. Compared to Jimmy and Tony, I'm a near-neophite on the subject of these beasties (I'm more of an 02 "expert") but from my own E30 M3 and the experiences I've had with the car, I will comment if I feel I have something useful to add.
BtW, if you haven't already checked: I have never sold or listed a car on BaT either… :^)/


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Trolling motor wiring guide
Learn about the features and technologies on all of our motors to you help choose which trolling motor is best for your boat. Shop Trolling Motor Accessories from the boating experts at Bass Pro
Shops. Find Replacement props, pull-cords, wires extension handles & more at basspro.com. Buy the MotorGuide Xi5 Trolling Motor with Sonar & Pinpoint GPS and more quality Fishing, Hunting and Outdoor gear at Bass Pro Shops. colorful 9 lead motor wiring festooning simple wiring diagram rh littleforestgirl net 12 Lead 480V Motor 3 phase 6 lead motor wiring diagram wiring diagram data u2022 rh parklager co 12 Lead 12 lead 480v motor wiring diagram 3 phase s kicker comp alpine type medium size of . Sep 23, 2017 · Can you run a 36 volt trolling motor on 24 volts? Will this damage the trolling motor? My dad has a 36 volt 120lb iPilot on his Haynie and I was wondering if I could take it off and put on my Maverick, I don't want it all of time just when
I am fishing alone. An innovative product designed to give you max control of your trolling motor with precise speed controls, idle button and speed memorization. View and Download MotorGuide Tour manuam online. Tour Outboard Motor pdf manual download. Enter Max RMS Wattage For All Amps & Electronics Below.
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Meyer belt conveyors feature standard formed channel legs, with adjustable feet, optional welded tubular floor supports in mild or stainless steel as well as suspension brackets available for overhead mounting. Custom Designs Meyer conveyors are designed to meet your requirements. ...
KP Industries is knowledge & performance. KP Industries supply a wide range of standard floor conveyor systems for a host of industry sectors. Working in production or warehousing environments, with manual, automated or robotic systems, KP Industries design engineers have many years of experience in providing efficient, effective systems, designed, manufactured and integrated according to your ...
The Model C incline cleated belt conveyor handles bags, boxes, cartons, and parts. It may be set at any angle from horizontal to 45-degrees for various uses, including floor-to-floor conveying and the transportation of materials from building to truck or box car.
A great place to visit for best pricing on overhead conveyors, floor conveyors, chain & trolleys, conveyor replacement parts, hooks and accessories, casters, wheels, rollers, ball transfers, conveyor support steel and screen guarding.
Overhead conveyors would save you space, but floor conveyors may be more practical considering your products. A large belt or power roller conveyor should do the job. Pallet conveyors may help if you wish to move pallets of rice/flour/etc and a vehicle conveyor loader should help if you need to move large loads from the factory floor to your van.
Floor to Floor Conveyors. Typically used to carry boxes (packaged items) up inclines or down declines, the New London Engineering line of Floor To Floor Conveyors are different from cleated belt conveyors in three ways: cost, belt, and the nose-over feature.
Find Floor Tow Conveyor Systems related suppliers, manufacturers, products and specifications on GlobalSpec - a trusted source of Floor Tow Conveyor Systems information. ... Conveyor belts are used in a wide variety of material transport applications such as manufacturing, food processing, and heavy industry. Belt construction and belt ...
A small amount of regular maintenance will ensure a long life for your ConveyorEase. You will need to inspect the conveyor, belt and accessories after usage to be sure no damage has occurred. Wash down the conveyor after use, removing any debris that may have collected under the belt.
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A very versatile conveyor, the Model TA can be used in many types of material handling situations such as assembly line operations, sorting, packing, and inspection. Conveyor sets up quickly and easily to save on installation time. • 10 Belt Widths • Reversible (with center drive) • Smooth, Slim Bed • Adjustable MS-Type Floor
About Conveyors. A wide variety of specialized conveyors & conveyor equipment is needed to create the perfect system. Bastian manufactures many types of custom conveyors: belt, roller, gravity, accumulation, flexible, plastic belt, & pallet handling conveyors.
This is a used BMI painted hopper conveyor in good condition. The hopper is 54"W x 45"D inside and 54"H from the floor. The discharge is 64-1/2" from the floor.
The conveyor shown on the far left was an unusual one in that the customer wanted it built onto an existing staircase. More commonly, however, such conveyors are "self-supported". Mezzanine Floor Incline Conveyors can help expand your available floor space
A conveyor belt carries supplies from the first floor to the second floor, which is 15ft higher. The belt makes a 60degree angle with the ground. How far do the supplies travel from one end of the conveyor belt to the other? Round to the nearest foot.
We will help you specify exactly the right conveyor for your application. Click for prices, video, specs and more. Login View Cart (0) View Quote (0) Checkout ... Belt Conveyors. Gravity Conveyors. Flexible Conveyor. Accumulation Conveyor. Portable Conveyors. Conveyor Accessories. Incline Conveyors. Pallet Conveyor.
For use in industrial applications, such as conveyor belts or floor-processing, this Alligator® lacing helps provide a vise-like grip while distributing belt tension evenly across belt width. It can be hammer-applied, for ease of installation. Features steel construction for durability.
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Incline Conveyors: Slider & Roller Bed ... Hinged steel belt conveyors are ideal for carrying bulk materials into hoppers, sorters, balers or shredders. ... It may be set at any angle from horizontal to 45-degrees for various uses, including floor-to-floor conveying and the transportation of materials from building to truck or box car.
Conveyor Belt 16 in. Wide x 6 ft. Long Ultimation. Made in USA. Conveyor belt systems are ideal for transporting packages of various sizes and shapes. Rubber conveyor belt / Belt conveyor system for industrial uses. Ships in two weeks.
Floor conveyors are, as you probably guessed, mounted on the floor. They are more commonly known by the specific conveyor technology that is used. The most common types are: ... Belt conveyors should not be used in situations where products may damage each other. Conveyor design must take into account the wear characteristics of the material ...
The hard black rubber material is a blend of neoprene, nitrile, and styrene butadiene rubber (SBR) and comes inserted with a cloth fabric. This cloth-inserted rubber is therefore ideal for use as industrial level pads, strips, and flaps.
Of all of the conveyor belt suppliers, you'll find the best value with us. Multi-Conveyor is your top of the line, complete conveyor manufacturer. Call for a quote: 800.236.7960. ... All of our equipment is manufactured at our facility, so we ship directly from our floor to your door.
Auto Tech Ford patent application puts freakin' conveyor belts in your three-row SUV. That's one way to ensure your car is packed to the gills.
Flat Belt Conveyors are made with a durable 3-1/2"D x 12-gauge galvanized steel slider bed and a black friction surface PVC belt for use in assembly, sorting and inspection. Power Conveyors include permanent adjustable leg supports that adjust from 34" to 38"H for added convenience.
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Conveyor System Cleaning. Extend the life of your conveying system, improve quality control, and and reduce operator fatigue. Schaefer Brush's channel and I-Beam sweeps provide continuous cleaning of all internal surfaces of floor-mounted or ceiling-mounted conveyor systems.
Floor to Floor Conveyors. Typically used to carry boxes (packaged items) up inclines or down declines, the New London Engineering line of Floor To Floor Conveyors are different from cleated belt conveyors in three ways: cost, belt, and the nose-over feature.
Used incline conveyors convey products and materials between floors, mezzanines, work platforms, docks, or overhead conveyor lines. There are many factors to consider when picking the right incline conveyor, and many options to choose from to meet your specific material handling needs. Some of the common styles of incline conveyor belts include ...


text: HeadlinesNY Schoolchildren to Get Free Eyeglasses The expanded program begins next school year. Published 5 months agoon January 23, 2019By INVISION Staff Share Tweet Kindergarten and first-grade students in New York City who need prescription glasses will get them for free as part of a newly expanded program, Chalkbeat reports.It's anticipated that about 33,000 pairs of eyeglasses will be distributed through the program, which is being offered in conjunction with Warby Parker. INVISION PodcastPodcast: What the Heck is Marketing? And What Should ECPs Focus on to Attract New Clients? INVISION PodcastPodcast: More Ways to Motivate Your Own Eyecare Business Team INVISION PodcastPodcast: Why Can't We All Just Get Along? The program is expected to cost $6 million.The expanded program begins next school year. The program has already been operating at 224 "community schools" throughout New York City, with 26,000 pairs of eyeglasses given out last year.Advertisement New York Mayor Bill de Blasio said, "Being able to read the board and materials provided in the classroom can make all the difference for students as they learn to read and write."Too often students have vision impairments that go untreated and undiagnosed."Read more at the ChalkbeatRelated Topics:children's visionLatest News Top click to Comment(Comment)Up NextEye Health Firm to Expand in 5 US RegionsDon't MissFrameri Lens and Frame Technology Up for Auction Advertisement SPONSORED VIDEOSPONSORED BY REICHERTSee How the Reichert Phoroptor® VRx Transformed this Eye Care PracticeWhen Rochester, NY-based Eyesite designed its beautiful new facility, optometrists Benjamin Peters and Justin Verone chose the Reichert® Phoroptor® VRx. With its state-of-the art design and performance, the designed and assembled in the U.S.A. Phoroptor VRx has saved both time and money, say the owners. See how technology and design work together to provide Eyesite's patients with an optimal eye care experience. This is the first in a video series created by Reichert to share stories from professionals who are passionate about eye care, their patients, technology and practice management.For more information about the Reichert® Phoroptor® VRx, click here.You may like VSP Global Enters Brick-and-Mortar with 2 Stores Allergan to Be Acquired in $63M Deal Approach Your Business Like A Customer Would and More Manager's To-Dos for JulyPromoted Headlines Fashion, Innovation, and Technology: A Winning CombinationSERENGETI EYEWEAR See How the Reichert Phoroptor® VRx Transformed this Eye Care PracticeReichert Safilo's "American Eyes" Video Celebrates Elasta and Emozioni starringECPs Peter Tacia and Heidi DancerSafiloHeadlinesVSP Global Enters Brick-and-Mortar with 2 Stores They're located in Chicago. Published 20 hours agoon June 26, 2019By INVISION Staff RANCHO CORDOVA, CA – VSP Global enters brick-and-mortar retail with the opening of its first two Eyeconic stores in the country.The stores are located in Chicago. They will serve as an extension of VSP's ecommerce site, "connecting products, services and a VSP network doctor to retail-minded consumers who are looking for experiences that bridge the divide between digital and physical," according to a press release."We are thrilled to bring the very first Eyeconic stores to Chicago and offer customers a differentiated eye care and eyewear experience," said Bill Vaughan, president of VSP Retail. "Transparent prices and seamless digital and physical retail access are the cornerstones of our brand. And in partnership with a Doctor of Optometry, we now offer comprehensive eye exams using state-of-the-art technology to ensure eye health and wellness remains the focal point of our customer journey."As previously announced, VSP chose to launch the Eyeconic stores in Chicago "based on higher out-of-network claims the company was seeing at optical chains and mass retailers in the city." VSP Vision Care is the nation's largest not-for-profit vision benefits company and covers one in four people in the U.S., the release explains.The first store, located at 1647 North Damen Ave., opened to the public on June 15 and will host a grand opening celebration on June 29. The second store, located at 916 W. Randolph St., will open to the public on July 13 and host a grand opening celebration on July 27."A strategic, wholly owned retail footprint helps meet client expectations and contributes to a healthy and competitive network," said Michael Guyette, president and CEO of VSP Global. "By reducing out-of-network leakage, we also ensure members in Chicago are getting the most value out of their benefits — particularly those who fall into the 20 percent of consumers who prefer mass retail and online-based eyewear stores over private practice. This also opens new employment opportunities for VSP network doctors who desire to practice full-scope optometry in a retail setting."Each Eyeconic store will feature a selection of about 500 men's, women's and kids' frames from over 30 brands. The stores will also offer all major brands of contact lenses. Patients can schedule eye exams online and browse eyewear before coming in to see a VSP network doctor."As we conducted research, we identified a unique, uncommitted consumer who is looking for simplified shopping, transparency and convenience when it comes to their eye care and eyewear-buying experience," said Vaughan. "We are building the Eyeconic brand to meet the needs of discerning customers. That includes many residents in Chicago's dense urban market of about 2.7 million people, where over 400,000 VSP members live and work today."Eyeconic stores are considered in network for most VSP, Cigna and MetLife members. Eyeconic also accepts private pay and most other vision insurance plans as an out-of-network option. Continue ReadingHeadlinesAllergan to Be Acquired in $63M Deal It will be a 'transformational transaction for both companies.' Published 2 days agoon June 25, 2019By INVISION Staff NORTH CHICAGO, IL, and DUBLIN — AbbVie Inc. plans to acquire Allergan plc, whose products include eyecare drugs, in a $63 million deal, the companies announced."This is a transformational transaction for both companies and achieves unique and complementary strategic objectives," said Richard A. Gonzalez, chairman and CEO of AbbVie. "The combination of AbbVie and Allergan increases our ability to continue to deliver on our mission to patients and shareholders."With our enhanced growth platform to fuel industry-leading growth, this strategy allows us to diversify AbbVie's business while sustaining our focus on innovative science and the advancement of our industry-leading pipeline well into the future."Brent Saunders, chairman and CEO of Allergan, said, "With 2019 annual combined revenue of approximately $48 billion, scale in more than 175 countries, an industry-leading R&D pipeline and robust cash flows, our combined company will have the opportunity to make even bigger contributions to global health than either can alone. Our fast-growing therapeutic areas, including our world class medical aesthetics, eye care, CNS and gastrointestinal businesses, will enhance AbbVie's strong growth platform and create substantial value for shareholders of both companies."Under terms of the deal, Allergan shareholders will receive 0.8660 AbbVie shares and $120.30 in cash for each Allergan share that they hold, for a total consideration of $188.24 per Allergan share. The transaction represents a 45% premium to the closing price of Allergan's shares on June 24.The transaction is subject to conditions including certain regulatory approvals and approval by Allergan's shareholders. Continue ReadingHeadlinesOptical Company to Close Its Doors It's the "only remaining manufacturer of glass lenses and polarized glass lenses in the USA." Published 3 days agoon June 24, 2019By INVISION Staff Sauk Rapids, MN-based X-Cel Optical is closing its doors.The Sauk Rapids facility will shut down permanently in June 2020, WJON-AM reports.The operation, part of Essilor of America, primarily manufactures bifocals, trifocals and glass lenses. A company spokeswoman told WJON that decreased demand for those products is a factor in the closure.The facility has 125 full-time employees, all of whom will be affected. 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4 Beds
4 Baths
— sqft
41 Conifer Park Ln NE
41 Conifer Park Ln NE, Atlanta, GA 30342
The BEST Buckhead location! Serene, quiet, tree lined upscale neighborhood. Walk to Phipps Plaza, Lenox Square or one of many great restaurants close by. Stunning, inviting, impeccably maintained home w/meticulous details throughout including custom lighting, custom trim & beautiful hardwood floors. Kitchen is a chefs delight w/top of the line appliances. 10 foot ceilings on main 9 ft ceilings up. A must see, light filled 3rd story retreat includes wet bar & separate full bath, perfect as a media room, office or workout room. PRIVATE PARK (one of two neighborhood parks) is fenced for residents pleasure only. Landlord pays for...Show More
Unit Amenities
1/2 Bathrooms: 1
Area: ATN1
Basement Description: Slab/None
Bedrooms: 4
Bonus Room, Den, Dining Room Seats 12+, Exercise Room, Family Room, In-law Suite or Apartment, Library/Office, Rec Room, Theater/Media Room
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River Cruise at International Spring Conference
2 Responses to "River Cruise at International Spring Conference"
Renee G on
April 21st, 2019 2:05 pm
Are there still reservations being accepted for the Riverboat Cruise? Do we need to download any sort of off form or can we send that in along with our registration? What do you prefer?
admin on
May 2nd, 2019 10:43 pm
You can send it in with registration. Thank you!
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Results 1 to 5 of 5
Newborn won't sleep in Moses basket
12-06-19, 09:26 #1Sarah D(2753)
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- Mar 2019
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Newborn won't sleep in Moses basket
My 4 week old baby will not sleep unless she is being held or in my bed while feeding! If I put her in her Moses basket she starts kicking her legs and wakes up instantly, I've tried putting her down as soon as she gets to sleep and waiting til she's in a deep sleep it makes no difference, she won't sleep in their in the day or night. I've tried persistently putting her back in her Moses and she just wants to breastfeed as soon as she gets in there and falls asleep at the breast then wakes up as soon as I put her back, the cycle repeats and repeats. I end up falling asleep feeding her so I now think it would be less risky to think about safe co sleeping rather than unintentionally falling asleep without planning to. My son was never like this I actually think babies seem to sleep better when they're formula fed and he slept well in his crib but she's breastfed and she only sleeps when feeding/ being held. My partner keeps asking if I want to go on formula coz I'm so tired and it's annoying me! Has anyone been through the same? Any tips would be greatly appreciated
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12-06-19, 13:11 #2angelmumma
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- Jul 2017
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I think it can be normal for newborns to sleep and settle better on formula but it makes sense if you think about it. Each formula feed is like a huge 7 course Christmas dinner for us. All we want to do after is sit in a chair and sleep it off.
Your babys behaviour is very normal for this age. Please google the fourth trimester and point your other half in that directions as well.
All baby has known is being close to you and hearing your heartbeat. Being on the breast is where they feel the safest and happiest.
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12-06-19, 20:07 #3Christina A(113)
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- Dec 2016
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Hi Sarah
Thank you for your post.
Sarah it is actually quite normal for very young babies to settle well on you or in your arms then wake as soon as they are put down. When your LO is in your arms she can smell your milk, hear your heartbeat and feel your warmth, she will also feel safe and secure as you are cradling her close all of these give her a similar sensation to being in the womb. There are a few things you could try to help her learn to settle or stay settled when put down in her basket, have a read through and see what you think:
* Place one of your worn t-shirts close to her basket when you put her down., this will smell of you and your milk and may help her feel close to you.
* Some young babies like to be swaddled when sleeping, this can help them feel secure and stops their arms falling to the side when placed down to sleep. Have a read through the advice here about swaddling to ensure you are doing it safely.
* Try placing her down in the basket awake and allowing her to fall asleep independently. You can be there with her, maybe try placing your hand on her tummy to help her settle without being picked up.
* White noise or similar background noise can help some young babies sleep more soundly.
Many parents do choose to co-sleep with their LO's. There is lots of helpful tips and advice about doing this safely in the following links:
Netmums - How to co-sleep safely
The lullaby trust - co-sleeping and safe sleeping
I hope that this will help and you all manage to get some sleep soon
All the best, Christina.Christina is a qualified Community Health Worker, and has been working as Netmums Parent Supporter since 2017. Find out more about Christina's work with Netmums.
The support Netmums Parent Supporters provide is not intended to be a substitute for professional advice from a health professional or any other qualified advisory organisation. Users should always seek professional advice relevant to their particular set of circumstances from a qualified health professional or other relevant professional organisations.
12-06-19, 20:18 #4TessB
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- Jan 2018
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Mine never would either! For some reason a lot of them hate the basket! she eventually after a few weeks just did it! Was thinking it would never happen but luckily it did! Hang in there! We tried everything aswell- absolutely everything! One night out of the blue she just slept- didnt kick off going in it, fell asleep by herself and slept! Strange little things!
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15-06-19, 08:42 #5Sarah D(2753)
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- Mar 2019
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Thank you
THANks for the advice I just put her in with one of my used boob pads- eew haha and I let her cry for a couple of minutes (not a big cry just a bit of shouting ha) then I picked her back up cuddled her then put down again, did this a couple of times and then fed her in between, all of a sudden after this she fell asleep in her basket and now she is sleeping independently for 2-3 hours a time! It's a miracle! Xxx


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Prayer Mountain Boys Academy is a therapeutic boarding school for troubled boys located in Central Georgia – Christian boarding schools or homes for troubled boys.
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Club Mephisto, in the Centre of Pilsen, at the corner of Goethe's streets and Kopecký orchards. The stylish interior in you energizing the right atmosphere. We are open from Wednesday to Saturday, from evening to morning. In addition to the best alcoholic and non-alcoholic drinks you can choose from a vast range of quality wines from Moravia, including, of course, several kinds of beer from Pilsen and high-quality Cuban cigars. The Club is available wi-fi hotspot and the atmosphere is enhanced by high-quality lighting and sound technology. From Tuesday to Saturday You our DJs are the biggest hits from rock ' n ' roll to the present and play even on request. – Translated by Automatic service
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Van Dyke made headlines again in April 2013, this time for an incident of a much different kind—one posing a threat to the actor's life, not celebrating it the way the prestigious event had just weeks earlier. The legendary performer announced that he was suffering from an "undiagnosed neurological disorder," posting on his Twitter page: "My head bangs every time I lay down. I've had every test come back that I'm perfectly healthy. Anybody got any ideas?" The famed TV personality was reportedly advised by his doctor to avoid plane travel and rest until further tests could be conducted to pinpoint the direct cause of his head pain.
Though The Dick Van Dyke Show got off to a slow start, it eventually developed quite a following; Van Dyke won over audiences with his good humor and likeability, and won three Emmy Awards for his work on the series. Decades after the show went off the air, in 1966, it remained a popular program in syndication. Following the show's end in 1966, Van Dyke starred on several other TV series, including The New Dick Van Dyke Show, but none captured the public's heart the way his first sitcom did.
Van Dyke left high school in 1944, his senior year, intending to join the United States Army Air Forces for pilot training during World War II. Denied enlistment several times for being underweight, he was eventually accepted for service as a radio announcer before transferring to the Special Services and entertaining troops in the continental United States.[11] He received his high school diploma in 2004 at the age of 78.[12]
^ Theo and his wife, Gachet and his son, and Signac, who all saw Van Gogh after the bandages were removed, maintained that only the earlobe had been removed.[142] According to Doiteau and Leroy, the diagonal cut removed the lobe and probably a little more.[143] The policeman and Rey both claimed Van Gogh severed the entire outer ear;[142] Rey repeated his account in 1930, writing a note for novelist Irving Stone and including a sketch of the line of the incision.[144]
In April 1876 he returned to England to take unpaid work as a supply teacher in a small boarding school in Ramsgate. When the proprietor moved to Isleworth in Middlesex, Van Gogh went with him.[35][36] The arrangement did not work out and he left to become a Methodist minister's assistant.[37] His parents had meanwhile moved to Etten;[38] in 1876 he returned home at Christmas for six months and took work at a bookshop in Dordrecht. He was unhappy in the position and spent his time doodling or translating passages from the Bible into English, French and German.[39] He immersed himself in religion, and became increasingly pious and monastic.[40] According to his flatmate of the time, Paulus van Görlitz, Van Gogh ate frugally, avoiding meat.[41]
Van Gogh entered the Saint-Paul-de-Mausole asylum on 8 May 1889, accompanied by his carer, Frédéric Salles, a Protestant clergyman. Saint-Paul was a former monastery in Saint-Rémy, located less than 30 kilometres (19 mi) from Arles, and was run by a former naval doctor, Théophile Peyron. Van Gogh had two cells with barred windows, one of which he used as a studio.[162] The clinic and its garden became the main subjects of his paintings. He made several studies of the hospital's interiors, such as Vestibule of the Asylum and Saint-Rémy (September 1889). Some of his works from this time are characterised by swirls, such as The Starry Night. He was allowed short supervised walks, during which time he painted cypresses and olive trees, including Olive Trees with the Alpilles in the Background 1889, Cypresses 1889, Cornfield with Cypresses (1889), Country road in Provence by Night (1890). In September 1889 he produced two further versions of Bedroom in Arles.[163]
In Paris in 1901 a large Van Gogh retrospective was held at the Bernheim-Jeune Gallery, which excited André Derain and Maurice de Vlaminck, and contributed to the emergence of Fauvism.[269] Important group exhibitions took place with the Sonderbund artists in Cologne in 1912, the Armory Show, New York in 1913, and Berlin in 1914.[273] Henk Bremmer was instrumental in teaching and talking about Van Gogh,[274] and introduced Helene Kröller-Müller to Van Gogh's art; she became an avid collector of his work.[275] The early figures in German Expressionism such as Emil Nolde acknowledged a debt to Van Gogh's work.[276] Bremmer assisted Jacob Baart de la Faille, whose catalogue raisonné L'Oeuvre de Vincent van Gogh appeared in 1928.[277][note 15]
During this period Van Gogh mastered the use of light by subjugating shadows and painting the trees as if they are the source of light – almost in a sacred manner.[252] Early the following year he painted another smaller group of orchards, including View of Arles, Flowering Orchards.[254] Van Gogh was enthralled by the landscape and vegetation of the south of France, and often visited the farm gardens near Arles. In the vivid light of the Mediterranean climate his palette significantly brightened.[255]
I purchased a sectional set from the Fort Wayne store last year and it has been nothing but a nightmare. Within a month it has stated to rip at the stitching. We called and they said we don't cover that it's the factory warranty. So we called them and was informed we called to late of the incident of the rip and it was not on the stitching even tho clearly the picture the guy took showed the stitching coming apart. Then a month later our dog threw up brown sugar all over or brown sectional and the oder is unbearable to the point where you can't sit on it. We purchased the extended stain warranty and you guessed it... It was not covered...... So a month ago they were have birthday sale so we go in looking for a bed and bed frame. They worked with us and got a good deal on a set. So last week they delivery was 2 hours late so we had to reschedule and my wife missed work. Now today they showed up with half our order and made me miss work bc they couldn't work with us on times to be delivered. Now they want us to miss work again to deliver the rest of the order next Thursday. So I sit down on my disgusting falling apart sectional and it clicks I'm done with this company and the empty promises and cancel the remainder of the order bc I need a mattress to sleep on tonight. Do not do business with this company unless you like terrible customer service...
Van Gogh wrote that with The Night Café he tried "to express the idea that the café is a place where one can ruin oneself, go mad, or commit a crime".[124] When he visited Saintes-Maries-de-la-Mer in June, he gave lessons to a Zouave second lieutenant – Paul-Eugène Milliet[125] – and painted boats on the sea and the village.[126] MacKnight introduced Van Gogh to Eugène Boch, a Belgian painter who sometimes stayed in Fontvieille, and the two exchanged visits in July.[125]
In April 2013, Van Dyke revealed that for seven years he had been experiencing symptoms of a neurological disorder, in which he felt a pounding in his head whenever he lay down; but despite his undergoing tests, no diagnosis had been made.[55] He had to cancel scheduled appearances due to fatigue from lack of sleep because of the medical condition.[56] In May 2013, he tweeted that it seemed his titanium dental implants may be responsible.[57]
Van Gogh returned home a fortnight later and resumed painting, producing a mirror-image Self-Portrait with Bandaged Ear and Pipe, several still lifes, and La Berceuse (Woman Rocking a Cradle; Augustine-Alix Pellicot Roulin, 1851–1930). Several weeks later, he again showed symptoms of mental disturbance severe enough to cause him to be sent back to the hospital. At the end of April 1889, fearful of losing his renewed capacity for work, which he regarded as a guarantee of his sanity, he asked to be temporarily shut up in the asylum at Saint-Rémy-de-Provence in order to be under medical supervision.
I've found a home here because actors have always said, 'He's really a dancer', and dancers said, 'No, no he's a singer', and singers said, 'No I think he's an actor.' I don't know, I was never that good at anything but I did a little bit of it all. I've never studied dancing but I've always loved to dance. I never sang anywhere except the shower and it took me forever to get into the high school choir. When I auditioned for Bye Bye Birdie (1963) I did a song and a little soft-shoe and for some reason they saw I could move. And I've never studied acting - which is maybe lucky otherwise I'd just be a copy of everybody else.
Though The Dick Van Dyke Show got off to a slow start, it eventually developed quite a following; Van Dyke won over audiences with his good humor and likeability, and won three Emmy Awards for his work on the series. Decades after the show went off the air, in 1966, it remained a popular program in syndication. Following the show's end in 1966, Van Dyke starred on several other TV series, including The New Dick Van Dyke Show, but none captured the public's heart the way his first sitcom did.
His film work affected his TV career: the reviews he received for his role as D.A. Fletcher in Dick Tracy led him to star as the character Dr. Mark Sloan first in an episode of Jake and the Fatman, then in a series of TV movies on CBS that became the foundation for his popular television drama Diagnosis: Murder. The series ran from 1993 to 2001 with son Barry Van Dyke co-starring in the role of Dr. Sloan's son Lieutenant Detective Steve Sloan. Also starring on the same show was daytime soap actress Victoria Rowell as Dr. Sloan's pathologist/medical partner, Dr. Amanda Bentley, and Charlie Schlatter in the role of Dr. Sloan's student, Dr. Jesse Travis.[29] Van Dyke continued to find television work after the show ended, including a dramatically and critically successful performance of The Gin Game, produced for television in 2003 that reunited him with Mary Tyler Moore. In 2003, he portrayed a doctor on Scrubs. A 2004 special of The Dick Van Dyke Show titled The Dick Van Dyke Show Revisited was heavily promoted as the first new episode of the classic series to be shown in 38 years. Van Dyke and his surviving cast members recreated their roles; although nominated for a Primetime Emmy,[30][31][better source needed] the program was roundly panned by critics. In 2006 he guest-starred as college professor Dr. Jonathan Maxwell for a series of Murder 101 mystery films on the Hallmark Channel.
Between 1885 and his death in 1890, Van Gogh appears to have been building an oeuvre,[221] a collection that reflected his personal vision, and could be commercially successful. He was influenced by Blanc's definition of style, that a true painting required optimal use of colour, perspective and brushstrokes. Van Gogh applied the word "purposeful" to paintings he thought he had mastered, as opposed to those he thought of as studies.[222] He painted many series of studies;[218] most of which were still lifes, many executed as colour experiments or as gifts to friends.[223] The work in Arles contributed considerably to his oeuvre: those he thought the most important from that time were The Sower, Night Cafe, Memory of the Garden in Etten and Starry Night. With their broad brushstrokes, inventive perspectives, colours, contours and designs, these paintings represent the style he sought.[219]
Van Gogh's mother came from a prosperous family in The Hague,[19] and his father was the youngest son of a minister.[20] The two met when Anna's younger sister, Cornelia, married Theodorus's older brother Vincent (Cent). Van Gogh's parents married in May 1851 and moved to Zundert.[21] His brother Theo was born on 1 May 1857. There was another brother, Cor, and three sisters: Elisabeth, Anna, and Willemina (known as "Wil"). In later life Van Gogh remained in touch only with Willemina and Theo.[22] Van Gogh's mother was a rigid and religious woman who emphasised the importance of family to the point of claustrophobia for those around her.[23] Theodorus's salary was modest, but the Church supplied the family with a house, a maid, two cooks, a gardener, a carriage and horse, and Anna instilled in the children a duty to uphold the family's high social position.[24]
After Van Gogh's first exhibitions in the late 1880s, his reputation grew steadily among artists, art critics, dealers and collectors.[262] In 1887 André Antoine hung Van Gogh's alongside works of Georges Seurat and Paul Signac, at the Théâtre Libre in Paris; some were acquired by Julien Tanguy.[263] In 1889 his work was described in the journal Le Moderniste Illustré by Albert Aurier as characterised by "fire, intensity, sunshine".[264] Ten paintings were shown at the Société des Artistes Indépendants, in Brussels in January 1890.[265] French president Marie François Sadi Carnot was said to have been impressed by Van Gogh's work.[266]
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While in Asnières Van Gogh painted parks, restaurants and the Seine, including Bridges across the Seine at Asnières. In November 1887, Theo and Vincent befriended Paul Gauguin who had just arrived in Paris.[111] Towards the end of the year, Vincent arranged an exhibition alongside Bernard, Anquetin, and probably Toulouse-Lautrec, at the Grand-Bouillon Restaurant du Chalet, 43 avenue de Clichy, Montmartre. In a contemporary account, Bernard wrote that the exhibition was ahead of anything else in Paris.[112] There Bernard and Anquetin sold their first paintings, and Van Gogh exchanged work with Gauguin. Discussions on art, artists, and their social situations started during this exhibition, continued and expanded to include visitors to the show, like Camille Pissarro and his son Lucien, Signac and Seurat. In February 1888, feeling worn out from life in Paris, Van Gogh left, having painted more than 200 paintings during his two years there. Hours before his departure, accompanied by Theo, he paid his first and only visit to Seurat in his studio.[113]
I've found a home here because actors have always said, 'He's really a dancer', and dancers said, 'No, no he's a singer', and singers said, 'No I think he's an actor.' I don't know, I was never that good at anything but I did a little bit of it all. I've never studied dancing but I've always loved to dance. I never sang anywhere except the shower and it took me forever to get into the high school choir. When I auditioned for Bye Bye Birdie (1963) I did a song and a little soft-shoe and for some reason they saw I could move. And I've never studied acting - which is maybe lucky otherwise I'd just be a copy of everybody else.


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text:
Veysel Sabri Hancer*
Istanbul Bilim University, Faculty of Medicine, Department of Medical Biology and Genetics, Istanbul, Turkey
Received Date: August 18, 2011; Accepted Date: August 25, 2011; Published Date: September 30, 2011
Citation: Hancer VS (2011) Genetics of Antiphospholipid Syndrome. Human Genet Embryol 1:e103. doi: 10.4172/2161-0436.1000e103
Copyright: © 2011 Hancer VS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Human Genetics & Embryology
The term "antiphospholipid syndrome" has been proposed to describe the association of arterial and venous thrombosis, recurrent fetal loss, and immune thrombocytopenia with a spectrum of autoantibodies directed against cellular phospholipid components. Because of the antigen spesificity of antiphospholipid antibodies (aPL) and the pathophysiology of thrombosis in antiphospholipid syndrome (APS) are heterogeneous and multifactorial, a single scenario can not explain the mechanisms of thrombophilia or pregnancy morbidity in patients. Investigation of the clinical epidemiology of APS is in its early stages. During the past 20 years, studies of aPL and APS have been made in many countries [1-11]. aPL appear to occur in all populations studied, with some variations noted in their frequency and in the clinical complications [1,9,10,12,13]. Environmental and genetic factors contribute to ethnic variation and susceptibility to APS and thus interethnic differences in disease patterns may be due to environmental or genetic factors, or both [1,14]. A genetic basis for aPL antibodies was suggested for the first time when a familial clustering of chronic false-positive syphilis test individuals were detected [15]. The first description about aPL showed two pairs of siblings with lupus anticoagulant (LA) [16]. Subsequently, primary APS was described [17] and Cevallos et al. [18] reported the development of primary APS in one woman whose identical twin sister was an asymptomatic carrier of aPL. Relatives of patients with systemic lupus erythematosus (SLE) or primary APS had a higher incidence of anticardiolipin antibodies (aCL) [19,20] suggesting that a genetic factor may relevant with aPL. Mackie et al. [21] reported three families having more than one member with LA and called familial lupus anticoagulants. The identification of several pedigrees with an increased frequency of aPL antibodies and the associated clinical manifestations further support the familial form of APS. In one of these studies, a large kindred in which nine individuals had aPL antibodies was described. Associated clinical manifestations included stroke, deep venous thrombosis and recurrent abortions [22]. In another study, clinical and laboratory abnormalities in seven families with more than one affected person with segregation analysis, Goel et al suggested that a susceptibility gene is inherited in an autosomal dominant patern [23]. Segregation studies rejected environment and autosomal recessive models, and the data were fitted best by a dominant or codominant model. However, linkage analysis showed independent segregation of APS and several candidate genes.
Genes associated with antiphospholipid syndrome
Human Leucocyte Antigen (HLA) Studies: HLA class II antigens (DR, DP, DQ) loci is located on chromosome 6 and these molecules are highly polymorphic. Therefore, HLA class II polymorphisms have been implicated in association with autoimmune responses, in particular antigen specific immune responses. In a study of 13 patients with the primary APS, HLA-DR4 and DRw53 were more frequently found, but no correction was made for multiple comparisons [24]. The data confirmed in a population from Spain [25] and Canada [7]. Studies of HLA alleles in patients with conventional aCL showed increased frequencies of HLA DR4 [26] or DR7 [25,27] in SLE population. DR7 also increased in Mexican patients with aCL [28]. Hartung et al. [29] reported that HLA-DR4 and DR7 increased in aCL positive patients in European SLE populations and aCL were significantly associated with DRw53. In a study of 20 patients with SLE and LA, an association with HLA-DQw7 (HLA DQB1*0301) linked to HLADR4 and/or -DR5 haplotypes was found in 70 % of patients and was significantly increased compared with 139 matched control individuals (p = 0.002) [30]. According to this study, several HLA-DQB1 alleles shared a common amino acid sequence (positions 71-77) in the third hypervariable region of the outermost domain. This HLA-DQB1 sequence, called TRAELDT, is distinct from those found in the HLADQB1 alleles of HLADQw2, -DQw4 and -DQw5 and, as such, may represent an autoantibody. However, LA may comprise heterogeneous autoantibodies, such as anti β2GPI, antiprothrombin and so forth, and in these studies investigators did not discriminate these heterogeneous antibodies. It is clear that HLA class II gene should not be considered to be a single genetic risk factor for APS because the antigen specificity of aPL and clinical manifestations are highly heterogeneous.
β2-Glycoprotein I: β2-glycoprotein I or apolipoprotein H is a single chain glycoprotein with a molecular weight of approximately 50 kD and 326 amino acid residues. A member of the short consensus repeat protein family, beta2-GPI is characterized by five 'sushi domains'. The fifth sushi-domain contains the binding site to phospholipid, and it attaches to activated cellular surfaces [31]. β2- GPI binds to various negatively charged phospholipids and inhibits intrinsic blood coagulation pathway [32], prothrombinase activity of human platelets [33] , and adenosine diphosphate (ADP) dependent platelet aggregation [34]. When β2-GPI binds to negatively charged phospholipids, it behaves as a cofactor for aCL binding and interacts with coagulation reactions. Several studies have shown the significance of anti-β2-GPI as an alternative enzyme linked immunosorbent assay (ELISA) with higher specificity than the conventional aCL ELISA. Moreover, many studies suggest that the presence of anti-β2-GPI is closely associated with clinical manifestations of APS and anti-β2- GPI play important roles in pathogenesis of APS such as platelet and endothelial cell activation and induction of tissue factor. Human β2-GPI gene is located on chromosome 17 and so far four common single nucleotide polymorphisms in protein coding region have been identified [35,36]. Eighty eight Ser/Asn, 247 Val/Leu, 306 Cys/Gly, and 316 Trp/Ser polymorphisms are located in exon 3, 7, 7, and 8 of β2- GPI gene, respectively. Val/Leu polymorphism at codon 247 has been extensively studied among these polymorphisms. Two hundred forty seven Val/Leu polymorphism is located between the phospholipid binding site in fifth domain and fourth domain of β2-GPI, one of the potential epitopes recognized anti-β2-GPI from patients with APS. 306 Cys/Gly, and 316 Trp/Ser polymorphisms may affect the structure of phospholipid binding site of domain 5 of β2-GPI [37]. 247 Val/Leu polymorphism can affect the conformational change of β2-GPI and the exposure of the epitopes for aCL. Hirose et al. [38] found that the 247 Val allele was more frequently detected in Asian patients with APS than in matched normal individuals. Furthermore, it reported an association between the Val247Val homozygous genotype and the presence of anti-β2 GPI antibodies only among Asian patients with APS. The authors found no evidence of an increased risk of thrombosis in this Asian population. Atsumi et al. [39] analyzed 247 Val/Leu polymorphism in a cohort of 88 British APS patients and found 247 Val was correlated with anti-β2-GPI production in patients with primary APS, and 247 Val may be important for β2-GPI antigenicity. Prieto et al. [40] suggested that Val/Val genotype at codon 247 played a role in the generation of anti-β2-GPI and in the expression of arterial thrombosis in Mexican primary APS. On the other hand, Camilleri et al. [41] found no association 247 Val/Leu polymorphism and the presence of anti- β2-GPI in the white population. There have been several reports of two common polymorphisms (306 Cys/Gly and 316 Trp/Ser) located in the fifth domain of β2-GPI. These two polymorphisms in the fifth domain affect the binding of β2-GPI to anionic phospholipids [42]. Kamboh et al. [43] found 316 Ser allele was protective against the production of aPL in SLE population. On the other hand, Gushiken FC et al. [44] found no significant correlation between these polymorphisms and the presence of aPL in 143 SLE and/or APS patients. Moreover, their results suggested that 316 Trp/Ser polymorphism might predispose to thrombosis as an independent risk factor in patients with SLE.
Additional genetic risk factors
All patients with aPL do not develop the clinical findings of APS. This suggests that additional genetic factors may be involved in the development of the clinical characteristics of APS. Polymorphisms in genes involved in thrombus formation have been examined. Factor V Leiden mutation that results 506Arg/Gln substitution is the most common factor for venous thrombosis. According to Fijnheer et al. [45]. Factor V Leiden was independent risk factor venous thrombosis, but not for arterial thrombosis in patients with SLE. Montaruli et al. [46] analyzed 60 patients with aPL and found the incidence of Factor V mutation was significantly elevated in patients with venous thrombosis. Pablos et al. [47] examined 75 patients with primary APS and 83 patients with SLE and aPL with or without thrombosis and found Factor V Leiden mutation was not significantly associated with vein thrombosis in patients with aPL. Brouwer et al. [48] determined the contribution of thrombophilic disorders including Factor V Leiden and the prothrombin G20210A mutation, alone or in various combinations with aPL, to the risk of thrombosis in patients with SLE. aPL, Factor V Leiden, and prothrombin G20210A mutation were reported as risk factors for venous thrombosis and these mutations potentiated the risk for venous thrombosis when these mutations were combined with aPL. In contrast with aPL, thrombophilic disorders did not influence the risk for arterial thrombosis. In another study [49] ninety four APS patients with documented thrombosis, 40 patients with persistent antiphospholipid antibody (aPLA) positivity but without thrombosis, and healthy controls were screened. They found that inherited protein C, protein S, and antithrombin deficiencies were rare in APS patients. The presence of factor V Leiden mutation was significantly higher in APS patients with thrombosis compared to healthy controls (p=0.0043). The prevalence of prothrombin G20210A mutation, however was not significantly increased in APS patients with thrombosis compared to patients without thrombosis (p=0.67). The presence of factor V Leiden mutation may define a small but important subgroup of patients who had high risk of both venous and arterial thrombosis. Known thrombophilic risk factors however, may influence the development of thrombotic complications in approximately 10% of APS patients. Prothrombin G20210A mutation is a risk factor for arterial and venous thrombosis [50]. This mutation was found to be rare in APS and several studies have not shown association between thrombosis in APS and this mutation [51-53]. APS patients with MTHFR 677TT genotype had a lower mean age at first thrombotic events and an increased average number of thrombotic events per person than APS patients with 677 CC or CT [54,55]. Fijnhaer et al reported that raised levels of homocysteine in SLE patients with arterial thrombosis but no MTHFR 677 C/T association with raised levels of homocysteine [56]. Tassies et al. [57] reported a higher frequency of the 4G allele in APS patients with arterial thrombosis than those without arterial thrombosis. On the other hand, Yasuda et al. [58] reported that polymorphism of PAI-1 gene did not significantly influence the risk for arterial thrombosis, venous thrombosis, or pregnancy morbidity in 77 Japanese and 82 British patients with aPL. A meta-analysis, Tsantes et al. [59] investigated the association between the PAI1 4G/5G polymorphism and the risk of venous thromboembolism (VTE) in 18 papers. According to this study, the 4G allele appears to increase the risk of venous thrombosis, particularly in subjects with other genetic thrombophilic defects. Diz-Kucukkaya et al. [60] found that factor XIII Val34Leu polymorphism decreased the risk of both arterial and venous thrombosis. Nevertheless, the results showed that the Leu34 allele had no protective effect in the development of thrombosis in patients with APS. On the contrary, de la Red et al. [61] found that this polymorphism was associated with a higher risk of thrombosis in patients with the presence of both aPL antibodies and high fibrinogen levels. They found no significant differences in Leu34 allele frequencies between primary APS, APS/SLE, SLE-aPL and asymptomatic-aPL patients, or between patients with and without thrombosis. In this study, the Leu34 allele seemed to have a protective effect on the development of thrombosis in patients with aPL antibodies, but only in those patients with high plasma fibrinogen values.
The elucidation of pathogenetic mechanism of APS may help to identify patients who are at high risk for thrombosis, and may improve management of the patients. Genetics of aPL and APS has been extensively examined in past 20 years. However, it has been difficult to determine genetic factors for aPL and APS because of the heterogeneity in the antigen specificity and in the pathogenesis of clinical manifestations related to APS. Several genetic factors may be involved in its pathophysiology, ethnic factors are also important. Genome-wide linkage analysis and larger cohort case-control association studies, as well as multicenter international collaborations would be useful for a better understanding of the genetic predisposition to develop APS.
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text:
World Wide Study Bible
a Bible passage
The Passover with the Disciples
12 On the first day of Unleavened Bread, when the Passover lamb is sacrificed, his disciples said to him, "Where do you want us to go and make the preparations for you to eat the Passover?" 13So he sent two of his disciples, saying to them, "Go into the city, and a man carrying a jar of water will meet you; follow him, 14and wherever he enters, say to the owner of the house, 'The Teacher asks, Where is my guest room where I may eat the Passover with my disciples?' 15He will show you a large room upstairs, furnished and ready. Make preparations for us there." 16So the disciples set out and went to the city, and found everything as he had told them; and they prepared the Passover meal.
The commentary does not cover Mark 14:12-16.


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Scanavino discovers a woman posing as a madam while he is undercover on a trafficking sting. It turns out she's there to track down her daughter, who disappeared three years ago. The team must then balance ethics and necessity as they search for her daughter while closing in on the perpetrator - an unexpectedly familiar face. Elsewhere, Benson gets disturbing news that may affect her son.
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