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Latest news articles
Added 25 days ago Drug news
Chiesi Farmaceutici licences Raxone for the treatment of Leber's Hereditary Optic Neuropathy worldwide except in US and Canada. Santhera Pharma
Santhera Pharmaceuticals announces that it has entered into an exclusive license agreement with Chiesi Farmaceutici, an international research-focused healthcare group...
Added 1 month ago Drug news
REVERSE Phase III trial of GS 010 shows improvement in Leber Hereditary Optic Neuropathy
GenSight Biologics reported a first set of results from Week 96 of the REVERSE Phase III clinical trial of GS...
Added 1 month ago Drug news
Novartis acquires Xiidra, a treatment for dry eye disease from Takeda.
Novartis announced that it has entered into an agreement with Takeda Pharmaceutical Company Limited to acquire the assets associated with...
Learning Zones
An epgonline.org Learning Zone (LZ) is an area of the site dedicated to providing detailed self-directed medical education about a disease, condition or procedure.
Chronic Lymphocytic Leukaemia (CLL)
Refine your knowledge of chronic lymphocytic leukaemia (CLL) with information on pathophysiology, diagnosis, treatment options and more
+ 1 more
See information on best practice in solid organ transplantation, and expert discussions on related hot topics.
Atopic Dermatitis
The Atopic Dermatitis Knowledge Centre is an educational resource, intended for healthcare professionals, that provides credible medical information on the epidemiology, pathophysiology and burden of atopic dermatitis, as well as diagnostic techniques, treatment regimens and guideline recommendations.
EADV 2018 Highlights
EADV Congress 2018: Bringing you the latest news and insights from 27th EADV Congress, 12-16 September 2018 Paris, France.
Chronic Obstructive Pulmonary Disease (COPD)
View highlights from recent congresses presented in new expert videos with leading physicians.
+ 7 more
Guidelines for the Management of Strabismus in Childhood
This guideline is designed for ophthalmologists managing children with strabismus (syn.squint), which is defined as a pathological misalignment of the visual axes.
Added 7 years ago
Journal articles
Intravitreal ocriplasmin for the treatment of vitreomacular traction and macular hole- A study of efficacy and safety based on NICE guidance.
Purpose: To evaluate the real world clinical outcomes of intravitreal ocriplasmin in patients with vitreomacular traction (VMT) with and without full thickness macular holes (FTMH) treated according to NICE guidance.
Added 11 months ago
Risk of corneal ulcer in patients with end-stage renal disease: a retrospective large-scale cohort study.
This retrospective, nationwide, matched cohort study included 92 967 patients with ESRD recruited between 2000 and 2009 from the Taiwan National Health Insurance Research Database.
Added 1 year ago
A new gel formulation of topical cysteamine for the treatment of corneal cystine crystals in cystinosis: the Cystadrops OCT-1 study.
Objective: To establish the safety and efficacy of a new gel formulation of cysteamine hydrochloride (CH) eye drops, for the treatment of corneal complications of nephropathic cystinosis.
Added 2 years ago
Vincent de Luise
Vincent de Luise MD FACS is assistant clinical professor of ophthalmology at Yale University School of Medicine, and adjunct clinical assistant professor of ophthalmology at Weill Cornell Medical College, where he is also on the Music and Medicine Initiative. Dr de Luise is physician ... Read more
The End of Sight at the End of Life
I presented this talk, "The End of Sight at the End of Life," on 4/4/2013 at a Harvard University "Think Tank" on Health and Aging. The two-day conference, held at the Charles Hotel in Cambridge, Massachusetts, brought together prominent scholars from the Harvard School of Public Health as well as global experts in economics, health care policy and longevity, for a fascinating and thought-provoking colloquium on the demographics and consequences of aging in all societies.
Strabismus in childhood
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Practice Pointer: How to assess eyes and vision in infants and preschool children
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Sciatica - Sciatica Cures... which work
Sciatica Cures... which work
Sciatica pain is that horrible pain that so many suffer from. It affects your enjoyment of life as you get that gnawing pain down your leg. You find even the simplest task hard as you can not relax without the fear of your
kicking in.
You may have spent years searching for a cure, and still remain with sciatic pain. You may have even felt like giving up and having that surgery, in the hope that something will at least ease your sciatica pain.
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So what sciatica cures work and which ones don't?
Now this is not going to be a witch hunt on all the products available. What this article will do is give you a set of guidelines to follow to see if the so called sciatica cure will ease your pain and most of all stop it returning. There are too many products to list, so you need to know which ones to look out for... the ones that are the miracle
The essential ingredients are:
Techniques to Release Muscle tension - the Piriformis muscle is the most common cause of sciatica pain. The sciatic nerve runs through the muscle and if tight it will irritate the sciatic nerve causing your
. So the first essential ingredient is a technique or two to release muscle tension.
Techniques to Strengthen Muscles - just like a see-saw, if one muscle is too tight there will be others that are too weak. You need exercises (not necessarily gym exercises or lifting weights) to improve the strength of muscles. Ideally ways to improve the nerve and blood supply as this is the prime reason they weaken in the first place.
Methods to Re-Align the Pelvis - the pelvic bones can distort. When they do this the muscles in the buttock (the Piriformis) will tighten, leading to sciatica. Pelvic distortion is also the biggest cause of lower back pain. If you fail to re-align the pelvis, long term sciatic relief will not happen.
Ways to Improve Lower Back Strength - there is no point just targeting the sciatic nerve unless you remove all lower back pain and the distortions there.
is caused by many factors. The lower spine and spine in general can help to cause sciatica. So you need ways to assess your spine for distortion patterns, to see if there are other factors causing your
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Techniques to Assess your Spine - if you can't see where the problem is coming from, you will not know how to eliminate it permanently. All so called
cures need to teach you ways to assess your spine and see where problems occur.
And that is it in a nut shell. If you can find a product that covers all these areas, then you have found a product that will not only eliminate your
, it will also stop it returning.
pain is dreadful, it drags you down, you feel frustrated from all the things you can't do. You want relief; you want to be able to move around without the fear of pain suddenly running down your leg. Sciatica is common and debilitating and it can be easily removed if the product you seek has all the right ingredients - assess, stretch, strengthen, re-align and re-balance.
Dr Graeme Teague is an expert in the structural field, and has been in practice since 1991. His newly launched web site The Back Pain Advisor - http://www.back-pain-advisor.com - strives to give you valuable and expert advice, tips and information on your back pain issues.
For more information on
issues just visit Sciatica - http://www.back-pain-advisor.com/sciatica.html
Receive a free e-book on back pain when you subscribe to our newsletter, just click here - Back Pain Adviser - http://www.back-pain-advisor.com/back-pain-adviser.html
Sean Rodriquez
Learn More about
Natural Sciatica Back Pain Treatments
Is Discectomy Spine Surgery Right for My Sciatica?
A discectomy is an invasive surgical procedure that removes herniated disc material that is protruding into the spinal canal and pressing upon nerve tissue. This pressure can cause numbness, weakness, tingling, or mild to severe pain in the back and leg. Discectomy surgery is a common treatment for herniated or ruptured discs of the lumbar spine and may be used for back pain sufferers who have...
How Can Magnetic Therapy Relieve Sciatica?
What is Sciatica? The longest nerve in your body, the sciatic nerve runs from your pelvis through your hip area and buttocks and down each leg. It divides into the tibial and peroneal nerves at the level of your knees. The sciatic nerve controls many of the muscles in your lower legs and provides feeling to your thighs, legs and feet. The term sciatica refers to pain that...
Top 7 Tips To Treat And Prevent Sciatica
It is pain in the butt quite literally. It can also be a pain in the hip, the thigh, the lower leg, or even the foot. In fact, the condition known as sciatica can send pain shooting anywhere in your lower body. What is causing all the commotion is the sciatic nerve, which is not one but a group of nerves bound together in a single sheath. The sciatica nerve runs from your lower back down each leg...
Referred Pain from the lumbar spine?
A Pain deep in the cheeks of your bottom can be referred from the lower back. There does not necessarily have to be pain in the lower back as well for pain to be referred into the buttocks. What are the symptoms of pain referred from the back? An aching in the buttocks that is difficult to pinpoint. The slump test may reproduce buttock pain which is eased when the neck is relaxed...
Sciatica Stretches and Information
I wanted to take the time to share with you a few sciatica stretches and information that you can use to help you. Sciatica is actually a symptom of back pain, but often people will refer directly to the symptom. Back pain is a nightmare for those people that have it. It affects everything you do because your back is central in that movement. You can roll over in bed and be caught with sharp...
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Range for First Day Of Classes Fall 2016
Hi there everyone, we meet again on the Custom made Calendar web-site to discuss first day of classes fall 2016
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Housing Notes – Miller Samuel Real Estate Appraisers & Consultants from first day of classes fall 2016 ,, source : millersamuel.com
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Federal Register Energy Conservation Program Test Procedures for from first day of classes fall 2016 ,, source : federalregister.gov
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In the Engineering Department, our engineers carefully examine the structural problems and suggests the best solutions for retrofitting the building. Some of these solutions are:
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- Strengthening of masonry, concrete and steel building using FRP materials
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K – Your assertions may be true for your stores, but that is not the case for the bulk of vehicles at auction. Many dealerships will send off brand trade ins to the auction (ex: Chevrolet dealer takes a Ford in on trade). Additionally dealerships will often "turn" their inventory sometime between 60-120 days. If they've purchased a car and it's not moving many dealers will move it to get their cash back out of the car and put it back into another car that they might be able to retail, and make a profit on.
Closing is usually required within 30 calendar days of sale or sooner. Only the seller may, at its discretion, exceed closing beyond 30 calendar days. Payment in full is due at Closing. Closing costs, including and without limitation, transfer taxes, documentary stamps, recording fees, and escrow fees will be paid by the Buyer and Seller in accordance with the customs of the county in which the property is located, unless stated otherwise in the individual Terms and Conditions of Sale.
Wakeley Collection - Antiques & Toy Auction3/16/2019 10:00 AM Wakeley Collection - Antiques & Toy Auction - 3/16/2019 10:00 AMAntiques & Collectibles, Primitives, Jadeite Kitchen Glassware, Early Roseville Pitchers-Bowls-Juvenile, DeLaval Adv., Folk Art, Americana, Red Wing Stoneware Collection, Cabinets & Bookcases, Lighting & Mid-Century, Artwork-Oil Paintings, Old [ View Full Listing ]
Copyright © Leaf Group Ltd. Use of this website constitutes acceptance of the BIZFLUENT.COM Terms of Use and Privacy Policy. The material appearing on BIZFLUENT.COM is for educational use only. It should not be used as a substitute for professional financial and/or investment advice. BIZFLUENT.COM does not endorse any of the products or services that are advertised on the website.
Any dispute arising as to any bidding shall be settled by Auctioneer at his sole discretion, and Auctioneer may put the lot in dispute up for sale again. Auctioneer reserves the right to refuse any bid, which it considers to be an insignificant advance over the preceding bid. No person shall bid on any lot of which he is the Consignor, agent, associate, or on behalf of the Consignor.
But ordinary folk typically don't have the means to attend high-end events like these, so we have to settle for the local auction block, with all of its police impounded "perp-mobiles," abandoned clunkers, and donated jalopies. But regardless of what kind of crap is being auctioned off, there are diamonds in the rough that can be unearthed, and as a bidder, you stand a chance of getting one for pennies on the dollar.
Over 600 lots of fresh to market antiques, collectibles, fine art, furniture, decorative arts, Asian, much more!!!! Follow the end of the Rainbow to William Bunch Auctions for your pot of gold filled with Sports items, clocks, fishing rods & reels, Waterford stemware, large variety of table lamps, jewelry, watches, stained glass panels, old photographs, books, modern & antique toys, [ View Full Listing ]
U.S. Marshal's Service Auctions : And finally, the U.S. Marshal's service auctions off some true bling as part of its mission to "combat major criminal activity by disrupting and dismantling illegal enterprises" and "depriving criminals of the proceeds of illegal activity." Once again, there is real estate, but also businesses, cash cars, collectibles — and more.
In economics we tend to think of auctions as a good way to get at the true price of an object. Of course, it isn't quite perfect as there's still problems with information asymmetries, and people can get a winner's curse because the people who err in thinking the car is worth more than it actually is are the ones who are likely to win. On the other hand, the price can go lower if there just aren't enough people at the auction for that to happen– you need at least two people over-valuing the object and willing to pay for it for one of them to over-pay.
Please consider that if you provide multiple deposit checks, and you are the Back-up Bidder for a property, one of your deposit checks will be utilized for that property, and will not be able to be applied to bid on another property. As the back-up bidder, your deposit check will be returned within three business days of receipt of the High Bidders full deposit. Please see Terms of Sale for details regarding the Back-Up bid deposit.
US government car auctions offer cars at great prices. The most imperative thing, which you should be aware of, is the timings of these local vehicle auctions. Apart from that, the other two things, which should be on your checklist, include: Vehicle Identification Number (VIN #) of the vehicle for running through the CAFEX website to acquire its past history and the warranty periods associated with it. Again, you should remember that these cars are to be brought at the least possible price. So, you should avoid bidding high even if the pair of wheels is too attractive to miss out.
Easy Payment: Pay manually or use Auto Pay! Manual payment allows you to choose which card you want to use on every transaction. Auto Pay is set up through your account details. By keeping a valid payment method on file, your auctions will be processed automatically so that you never miss a payment! Special discounts are available to customers choosing Auto Pay.


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Chad Childers has been a music lover since his parents dragged him along to an Aerosmith/Bachman Turner Overdrive show as an infant. His love of music turned into a career in the mid-90s when he left a job in the Midwest as a librarian and moved to California to intern for Westwood One Radio. That led to work researching for Casey Kasem's countdown shows, writing and producing the alternative and active rock-related prep services SpinFax, The Fax, and Rip, Read and Rock as well as doing interviews across all music and entertainment formats.
Chad Childers
Black Label Society Announce Headline Tour With Black Dahlia Murder + Alien Weaponry
The Black Dahlia Murder and Alien Weaponry will fill out the rocking bill.
Scott Stapp Extends Touring Into the Fall
See the second leg of dates and get ticketing info here.
Joe Perry Reflects on Iconic 'Walk This Way' Video Bladerunner Guitar
The instrument is currently featured in the New York Metropolitan Museum of Art's 'Play It Loud' exhibit.
In This Moment Book 'Mother's House of Horror' Fall Headline Tour
A spooky lineup of support acts will join them on this 'traveling All Hallows Eve masquerade.'
Rockers React: Rock + Metal Community Support Dave Mustaine During Throat Cancer Battle
See the messages of support and encouragement.
Report: Chris Cornell Estate in Dispute Over Daughter's College Tuition
The singer's daughter filed a claim after her tuition was held up.
Report: Lawsuits Expected Over Lost Master Recordings From 2008 Universal Studios Fire
Los Angeles litigators reveal legal action may be coming soon over the lost recordings in the 2008 Universal Studios fire.
My Chemical Romance's Frank Iero + Ray Toro Reunite for First Time on 'One on One' Session
The two bandmates were back together again recently.
Irish Councillor Calling for Behemoth Concert Ban Over Satanic Practices
The band's background has upset another political figure.
Skillet Unveil Two New Songs, While Band Reaches Streaming Milestone
These are the best of times for Skillet.
Report: Woodstock 50 Lost Watkins Glen Venue Due to Missed $150K Payment
More details have surfaced on the latest obstacle to putting on this year's event.
A Day to Remember Go Electronic With Marshmello for 'Rescue Me' Video
Watch the band's humorous island adventure with Marshmello.


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Events by Jennifer Craft
Destiny & Justin's Wedding
Saturday, May 25, 2019
More Posts
07 Jun, 2019
Favor Ideas
Hello Friday! Today, we want to share some of our favorite favor ideas from past weddings. The tradition of old-fashioned favors is starting to disappear. However, couples tend to have "useful" favors such as custom koozies at the bar. If you have a photobooth, the photo strip can be doubled as a favor. Some couples have dessert or candy buffets, which have little takeaway bags. We love the non-traditional cigar roller, which rolled cigars as a takeaway or for guests to enjoy at the event. Many
30 May, 2019
Brigid & Harrison's Wedding
Cheers to 4 years! We were honored to coordinate Brigid and Harrison's wedding at The Witte Museum on Saturday, May 30, 2015. The ceremony took place in the Texas Heritage Center, which set a beautiful scene with large glass windows. After the ceremony, guests enjoyed cocktails and hors-d'oeuvres in the Memorial Auditorium followed by the reception. Throughout the evening, guests were welcome to wonder the magical property and explore in the H-E-B Treehouse. Instead of a traditional first dance
15 May, 2019
Brittany & Kendall's Wedding
We had the joy to be a part of Brittany and Kendall's magical wedding on May 4, 2019! Not only is this couple SO much fun and kind, but their family and friends are too! It was a fantastic celebration! Brittany and Kendall were married at their church, with cocktail hour, dinner and LOTS of dancing to follow at Park 31 Venue. The band absolutely rocked the house, it would be literally impossible to not have a fun time! Everyone danced the Grand March and ended with Brittany + Kendall's First


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A Trip to the Bear Spa
Um ... hello! How are you? I feel like myself today, but I didn't so much yesterday. Yesterday, I had to make a trip to the bear spa. Yeah, yeah. I make a point of going every year or two. My fur isn't as white and fluffy as it used to be, so I get washed and enjoy the cleansing action of Woolite. Um ... I don't really look forward to it. Um ... in fact, I hate it. I get bopped around in the spa and I get water up my snout and it just isn't fun. And sitting around wet in the house can be really stressful. What if I don't dry quickly and get moldy! That wouldn't be very nice.
But Harriet doesn't like it when I get sniffy, so I go. And I want to set a good example for the other bears. Goofball still hasn't been washed and is pretty adamant that he never will be. Um ... I don't have the heart to tell him that mold creeps onto your body that way too. Yeah, yeah, it is a very fine line between being washed too frequently and not being washed enough.
Um ... here I am lounging in the kitchen before the big moment. Notice how calm and cool I look. I'm not shaking at all. The Wags Dog knows his duty and accepts his fate. Harriet gave me a kiss on the nose, too. That helped a lot.
When going to the spa, it is very important to wear protective clothing. It is a full contact sport. Oooh, your body can get so sore tossing and turning. The spa robe is a little restrictive. I was kind of hoping that we would get a bigger and softer spa robe when we moved to South Bend, but this is okay.
Again, notice how calm and cool I look as I wave goodbye to my bunny. Not a hint of fear or panic crosses my face.
Um ... okay ... now I am starting to panic. I hadn't seen the new spa room. It ... um ... it isn't very glamorous. I don't think Hollywood stars go to this spa. It looks like a dungeon down here. Um ... I think I am the cleanest thing down here. Um ... why did I get sent somewhere dirty to get clean? ... Hello? ... Hello! ... Can anyone hear me? ... Scared and lonely bear here. ... Hello!
Um ... I made it out of the bear spa, but I am not happy about it. I am not happy. Not one bit. I am cold and wet and worried that I might get moldy.
Oooh, my bunny George came down to sit with me while I dry. Um ... he must like me a lot. I like him, too. And now that I think about it, I kinda like sitting about the heating vent. It is blowing warm air on my tookus. Um ... am I allowed to use strong language like tookus on the blog? Um ... anyhow, the air is dry, so I don't think I will get moldy. It is verrry important to wash your bears on days when there is low humidity. Humidity is the natural enemy of teddy bears.
Um ... this is more like it. After all that stress, I needed to recover with my loyal George and Lobby. It isn't very often that I get the body pillow and bed all to myself. I guess this is the reward that a bear gets for extreme bravery.
But ... um ... I'll let you on a little secret. I now have a secret weapon against Ozzie. Yeah, yeah. I don't know whether it was the spa or the drying rack, but I am really, really staticky. I'm kind of like the empereor in Return of the Jedi. Lightning shoots from my paws! And my fur holds all type of funny shapes. But mostly, I'm going to shock Ozzie when he comes to bed.
Ooooooh, Oozzzziiiieeee! Oooooooh, Ooozzzzziiiieee! Um ... I have something to tellll youuuuuuuu!


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R8,000 pm
1 Bedroom Flat To Let in Durban North
Situated in a save and secure suburb of Durban North, this one bed cottage is available to rent...
R8,500 pm
2 Bedroom House To Let in Durban North
Lovely and spacious 2 bedroom garden flat. Perfect for a professional couple. Situated in a...
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Disclaimer: While every effort will be made to ensure that the information contained within the Seeff Property Group website is accurate and up to date, Seeff Property Group makes no warranty, representation or undertaking whether expressed or implied, nor do we assume any legal liability, whether direct or indirect, or responsibility for the accuracy, completeness, or usefulness of any information. Prospective purchasers and tenants should make their own enquiries to verify the information contained herein.


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Werktags vor 23:00 Uhr bestellt - in zwei Werktagen geliefert
60 Tage 'Nicht zufrieden - Geld zurück' Garantie
Mit Klarna auf Rechnung kaufen
Falls vorrätig, werktags vor 23 Uhr bestellt – in zwei Werktagen geliefert
420 motivierte Mitarbeiter stehen für Sie bereit
Bestellungen ab 20 € versandkostenfrei
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What is a B-stock product?
A product becomes B-stock when it can no longer be sold as new. It can simply be a product that has been returned by a customer or it may have packaging that is damaged or missing. It's possible that the product itself may show slight signs of use or damage too. All B-stock products are fully checked to ensure that they work properly and you can find details of why the product is a B-stock in the information above.
B-stock information
The B-stock tab on the product page shows information about the B-stock product. Be aware that this information supersedes anything you may read in the product description.
The product description includes text and specifications about the product in its brand-new state. It's possible that a B-stock item may be missing accessories mentioned in the text or specifications, for instance, but if so, this will always be mentioned in the B-stock information. B-stock products also include photos of the actual B-stock item so that you can see exactly what it looks like.
B-stock photos
The B-stock photos allow you to see the actual B-stock product you are considering purchasing. The photos show the following:
- Photo of the brand new product
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Packaging in good condition: undamaged (sticky tape residue may be visible)
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Yes! Our 60-Day Trial Period also applies to B-stock products.
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The ambitious modern-day DJ wants more control than ever when it comes to making their live performance a success. To enable them to control lighting effects as well, Pioneer have developed the RB-DMX1 lighting interface with Rekordbox (5.1) software. The great thing about Lighting mode in Rekordbox 5.1 is that you can create a light sequence based on the beat of your own track selection. That saves you a lot of preparation time for getting your light and audio to sync! Incidentally, you do need to do a (little) bit of programming in Rekordbox, but the software is very user-friendly. In order to direct Rekordbox 5.1 to your spotlights, moving heads, smoke machines and lasers, the Pioneer RB-DMX1 DMX interface is the perfect choice!
Features of the Pioneer RB-DMX1
This interface has one DMX universe and 512 DMX channels, so multiple lights can be controlled by a single DMX channel for even more possibilities. It's compact and built to last, making it suitable for taking on the road. Pioneer have been generous to include Rekordbox DJ, which is a considerable investment on its own.
|Zustand des Artikels
|mit Gebrauchsspuren (nicht beschädigt)
|Licht & Deko
|Gewicht (inkl. Verpackung)
|502 gr
|Maße (inkl. Verpackung)
|20,0 x 6,0 x 14,0 cm
- Pioneer RB-DMX1
- lighting interface for Rekordbox 5.1
- number of DMX channels: 512 (1 universe)
- rugged road-proof construction
- compatible with PC and Mac via USB
- includes license for Rekordbox DJ
- includes AC adapter DC 5V
- dimensions: 90 x 90 x 42 mm
- weight: 0.3 kg
Bewerten Sie das Produkt Haben Sie Fragen zum Produkt?


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Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity.
- Angus Crawford Cameron, Jon J. Read, +19 authors Federico Gómez de las Heras
- The Journal of biological chemistry
- 2004
Plasmodium falciparum, the causative agent of malaria, relies extensively on glycolysis coupled with homolactic fermentation during its blood-borne stages for energy production. Selective inhibitors… (More)
- Richard K Haynes, Burkhard Fugmann, +23 authors Axel Roemer
- Angewandte Chemie
- 2006
Neutralizing monoclonal antibodies to glycosylphosphatidylinositol, the dominant TNF-alpha-inducing toxin of Plasmodium falciparum: prospects for the immunotherapy of severe malaria.
- Lyn Schofield, L Maryori Vivas, Francine Hackett, Peter Gerold, Ralph T. Schwarz, Souvenir D. Tachado
- Annals of tropical medicine and parasitology
- 1993
Tumour necrosis factor-alpha (TNF-alpha) is an endogenous mediator of shock and inflammation. Many of the life-threatening and severe pathologies associated with complicated and cerebral malaria are… (More)
- Françoise Nepveu, Sothea Kim, +20 authors Jean-Pierre Nallet
- Journal of medicinal chemistry
- 2010
A series of 66 new indolone-N-oxide derivatives was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ… (More)
- Ana Maria Pacin, H.H.L. González, Miriam Etcheverry, Silvia Liliana Resnik, L Maryori Vivas, Silvia Espín
- Mycopathologia
- 2003
Freshly harvested soybean, rice and corn from farms and corn-based pelleted feeds were collected from ranches from the coastal and mountain regions in Ecuador during 1998, and assessed for fungal… (More)
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.
- Yongyuth Yuthavong, Bongkoch Tarnchompoo, +16 authors David Matthews
- Proceedings of the National Academy of Sciences…
- 2012
Malarial dihydrofolate reductase (DHFR) is the target of antifolate antimalarial drugs such as pyrimethamine and cycloguanil, the clinical efficacy of which have been compromised by resistance… (More)
Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
- Paul Michael O'neill, Richard K. Amewu, +16 authors Stephen A Ward
- Angewandte Chemie
- 2010
Artemisinin (1) is an extract of the Chinese wormwood Artemisia annua and has been used since ancient times to treat malaria. Today, semisynthetic derivatives artesunate (2) and artemether (3) are… (More)
- L Maryori Vivas, L. Mason Rattray, +4 authors Simon Croft
- Acta tropica
- 2008
Pyronaridine is a Mannich base anti-malarial with demonstrated efficacy against drug resistant Plasmodium falciparum, P. vivax, P. ovale and P. malariae. However, resistance to pyronaridine can… (More)
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria
- Patrice Nsangou Mimche, Donatella Taramelli, L Maryori Vivas
- Malaria Journal
- 2011
The clinical manifestations of cerebral malaria (CM) are well correlated with underlying major pathophysiological events occurring during an acute malaria infection, the most important of which, is… (More)
Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo.
- L Maryori Vivas, L. Mason Rattray, +5 authors Simon Croft
- The Journal of antimicrobial chemotherapy
- 2007
OBJECTIVES The in vitro and in vivo efficacy and drug-drug interactions of the novel semi-synthetic endoperoxide artemisone with standard antimalarials were investigated in order to provide the basis… (More)


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Explore Gallery of Brennan Sofa Chairs
Showing Photo About Brennan Sofa Chairs Pertaining to Well Known Jackson Furniture Brennan Large Chair And A Half For Formal Living
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Vsitours.com - Tour The France Jerseys. Linked to Tour The France Jerseys, Responsible tourism indicates all tourism specifically dependent on the usage of all-natural daily life e.g. wildlife and landscape. Mother nature centered tourism involve eco-tourism and mass tourism.
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Tours are an easy way to see dream destinations. If you're one of individuals people that enjoy travel but hate to organize everything yourself and also have others plan and demonstrate around, an excursion clients are the answer.


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Vietnam province to build 30MW solar PV plant
The large-scale PV plant brings Vietnam one step closer to its aim of generating 10% of electricity from renewable energy sources by 2030. Source: Flickr/guido da rozze
Vietnam is set to build a brand new 30MW solar PV plant in the north-central province of Thanh Hoa.
The plant is being developed as a joint venture between local energy companies Song La Energy JSC and Song Lam Investment & Construction and is being entirely domestically-funded, with a total investment of VND800 billion (US$35 million). Son La Energy JSC's Sinh Tien Tran told PV Tech that the companies are still in the process of selecting banks to finance the project.
However, the two firms will directly finance 30% (VND242 billion) (US$10.6 million) of the cost, while the remaining 70% will be covered by commercial banks.
Song La Energy JSC told PV Tech that construction is expected to start in Q4 2017 with commercial operation anticipated for Q4 2018. The project will be located on 650,000 square meters of land in the Yen Dinh District, around 160km south of Hanoi.
The plant will also be comprised of 90,640 c-Si polysilicon modules, which Song La Energy said it selected for their popularity in the international market, as well as their competitive purchase and installation price, durability and low annual generation attenuation.
Vietnam's solar market
The large-scale PV plant brings Vietnam one step closer to its aim of generating 10% of electricity from renewable energy sources by 2030. Local authorities have stated that the country's burgeoning renewable energy market is generating a profit for investors as they join Vietnam's push towards clean energy.
"During operation, the output generated by the farm shall be a clean significant power addition to power demand of Thanh Hoa province in particular and the surrounding area in general. The farm construction is in accordance with government orientation of clean power development and has a part in reduction of pollution, carbon emission caused by fossil fuels," said Sinh Tran Tien.
The country's electricity demand is expected to grow 13% annually over the next four years.
Vietnam also recently confirmed its long-awaited feed-in tariff (FiT) scheme which will open 1 June 2017 to 30 June 2019.
"The country's feed-in tariff regime plays an important role as leverage for solar development to take full advantage of Vietnam's solar potential," added Tien.
Solar Power International
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Solar & Storage Finance Asia
Solar & Storage Finance Asia returning to Singapore for its 5th edition, will be the meeting point for developers, financiers and investors across the region. Explore in depth the opportunities of the different countries via case studies, business and financial models that will foster growth in the region with particular focus on Thailand, Philippines, Indonesia, Taiwan, Korea, Cambodia, Singapore, Malaysia & Vietnam. The programme has been designed to enable you to win business and understand new opportunities in the market. Key topics include floating solar, project finance for PPAs, modernization of the grid and strategies for structuring and designing hybrid deals.
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Traders A and B in the previous example are hedgers. However, futures contracts, once they exist, can also be bought and sold in their own right. This is where futures get interesting for speculators. Say that Speculator X believes the price of a ton of pork belly will rise to 1,200 USD in 3 months' time, so buying the futures contract at 1,000 USD is a good deal. He can then sell the contract to bacon producers who want to buy pork bellies at 1,000 USD. The option to buy at a specified price in the future is known as a call option. The price of call options rise when traders assume that the price of the underlying asset will rise.
The data contained in this website isn't real-time or necessarily accurate, meaning prices are indicative and not appropriate for trading purposes. Your capital is at risk. This website is intended as a source of information only, not financial advice. Under no circumstances should you trade commodities, select a broker or perform any other task connected with commodity trading without taking professional advice first. Commodities can fall in value as well as rise in value: substantial losses can be made commodity commodity trading or trading with CFD services.
Each Fund generally engages in closing or offsetting transactions before final settlement of a futures contract wherein a second identical futures contract is sold to offset a long position (or bought to offset a short position). In such cases, the obligation is to deliver (or take delivery of) cash equal to a specific dollar amount (the contract multiplier) multiplied by the difference between the price of the offsetting transaction and the price at which the original contract was entered into. If the original position entered into is a long position (futures contract purchased), there will be a gain (loss) if the offsetting sell transaction is carried out at a higher (lower) price, inclusive of commissions. If the original position entered into is a short position (futures contract sold) there will be a gain (loss) if the offsetting buy transaction is carried out at a lower (higher) price, inclusive of commissions.
Additions such as Zerocoin have been suggested, which would allow for true anonymity.[54][55][56] In recent years, anonymizing technologies like zero-knowledge proofs and ring signatures have been employed in the cryptocurrencies Zcash and Monero, respectively. Cryptocurrency anonymizing implementations such as Cloakcoin, Dash, and PIVX use built in mixing services, also known as tumblers.[57]
A Bitcoin (spot or futures) exchange (like any online trading firm) charges its clients a fee to carry out trading activities. As exchanges face the risk of hacking and theft, it is wise not to trust an exchange with all your coins. You should split and keep part of them in other devices or cold storage. Now with bitcoin futures being offered by some of the most prominent marketplaces, investors, traders and speculators are all bound to benefit. These centralized marketplaces will facilitate trade based on a trader's outlook for bitcoin prices, gain exposure to bitcoin prices or hedge their existing bitcoin positions. Overall, the launching of bitcoin futures by Cboe and CME will facilitate price discovery and price transparency, enable risk-management via a regulated bitcoin product and give a further push to bitcoin as an accepted asset class. (For more, see: The Risks Of Buying Bitcoins.)
Like any futures contract, trading in XBT futures is not suitable for all investors and involves the risk of loss. The risk of loss in XBT futures can be substantial. Market participants should, therefore, carefully consider whether such trading is suitable in light of their own circumstances and financial resources. For additional information regarding futures trading risks, see the Risk Disclosure Statement set forth in CFTC Regulation 1.55(b).
On May 7, 2014, the SEC published an investor alert that highlighted fraud and other concerns relating to certain investment opportunities denominated in bitcoin and fraudulent and unregistered investment schemes targeted at participants in online bitcoin forums. On July 25, 2017, the SEC issued a Report of Investigation or Report which concluded that digital assets or tokens issued for the purpose of raising funds may be securities within the meaning of the federal securities laws. The Report emphasized that whether a digital asset is a security is based on the particular facts and circumstances, including the economic realities of the transactions. This was reiterated in a December 11, 2017 Public Statement emphasizing the risks of investing in digital assets such as bitcoin and noting the possibility that bitcoin and other digital assets may be deemed to be securities. The SEC continues to take action against persons or entities misusing bitcoin in connection with fraudulent schemes (i.e., Ponzi scheme), inaccurate and inadequate publicly disseminated information, and the offering of unregistered securities.
of Section 24(d) of the 1940 Act. The Trust has been granted an exemption by the SEC from this prospectus delivery obligation in ordinary secondary market transactions involving Shares under certain circumstances, on the condition that purchasers of Shares are provided with a product description of the Shares. Broker-dealer firms should note that dealers who are not "underwriters" but are participating in a distribution (as contrasted to an ordinary secondary market transaction), and thus dealing with Shares that are part of an "unsold allotment" within the meaning of Section 4(3)(C) of the 1933 Act, would be unable to take advantage of the prospectus delivery exemption provided by Section 4(3) of the 1933 Act. Firms that incur a prospectus-delivery obligation with respect to Shares are reminded that under Rule 153 under the 1933 Act, a prospectus delivery obligation under Section 5(b)(2) of the 1933 Act owed to a national securities exchange member in connection with a sale on the national securities exchange is satisfied if a Fund's prospectus is made available upon request at the national securities exchange on which the Shares of such Fund trade. The prospectus delivery mechanism provided in Rule 153 is only available with respect to transactions on a national securities exchange and not with respect to other transactions.
The proof-of-stake is a method of securing a cryptocurrency network and achieving distributed consensus through requesting users to show ownership of a certain amount of currency. It is different from proof-of-work systems that run difficult hashing algorithms to validate electronic transactions. The scheme is largely dependent on the coin, and there's currently no standard form of it. Some cryptocurrencies use a combined proof-of-work/proof-of-stake scheme.[18]
Below is a description of various types of money market instruments and other debt instruments that a Fund may utilize for investment purposes, as "cover" for other investment techniques such Fund employs, or for liquidity purposes. Other types of money market instruments and debt instruments may become available that are similar to those described below and in which the Funds also may invest consistent with their investment goals and policies. Each Fund may also invest in pooled investment vehicles that invest in, and themselves qualify as, money market instruments.
Gains or losses attributable to fluctuations in exchange rates that occur between the time a Fund accrues income or other receivables or accrues expenses or other liabilities denominated in a foreign currency and the time the Fund actually collects such receivables or pays such liabilities generally are treated as ordinary income or ordinary loss. Similarly, on disposition of some investments, including debt securities and certain forward contracts denominated in a foreign currency, gains or losses attributable to
CCC/CC/C – Very highly speculative credit quality. In danger of defaulting on financial obligations. There is little difference between these three categories, although CC and C ratings are normally applied to obligations that are seen as highly likely to default, or subordinated to obligations rated in the CCC to B range. Obligations in respect of which default has not technically taken place but is considered inevitable may be rated in the C category.
Subject to the general supervision by the Board, the Advisor is responsible for decisions to buy and sell securities and derivatives for each of the Funds and the selection of brokers and dealers to effect transactions. Purchases from dealers serving as market makers may include a dealer's mark-up or reflect a dealer's mark-down. Purchases and sales of U.S. government securities are normally transacted through issuers, underwriters or major dealers in U.S. government securities acting as principals. Such transactions, along with other fixed income securities transactions, are made on a net basis and do not typically involve payment of brokerage commissions. The cost of securities purchased from an underwriter usually includes a commission paid by the issuer to the underwriters; transactions with dealers normally reflect the spread between bid and asked prices; and transactions involving baskets of equity securities typically include brokerage commissions. As an alternative to directly purchasing securities, the Advisor may find efficiencies and cost savings by purchasing futures or using other derivative instruments like total return swaps or forward contracts. The Advisor may also choose to cross -trade securities between clients to save costs where allowed under applicable law.
Darknet markets present challenges in regard to legality. Bitcoins and other forms of cryptocurrency used in dark markets are not clearly or legally classified in almost all parts of the world. In the U.S., bitcoins are labelled as "virtual assets". This type of ambiguous classification puts pressure on law enforcement agencies around the world to adapt to the shifting drug trade of dark markets.[94]
This Statement of Additional Information ("SAI") is not a prospectus. It should be read in conjunction with the Prospectus of ProShares Trust (the "Trust"), dated October 1, 2017, the Prospectus dated November 16, 2017 for ProShares Decline of the Retail Store ETF, the Prospectus dated November 16, 2017 for ProShares Long Online/Short Stores ETF, the Prospectus dated , 2018 for ProShares Bitcoin Futures Strategy ETF, the Prospectus dated , 2018 for ProShares Short Bitcoin Futures Strategy ETF, the Prospectus dated , 2018 for ProShares Blockchain/Bitcoin Strategy ETF, and the Prospectus dated , 2018 for ProShares Bitcoin Futures/Equity Strategy ETF each as may be amended or supplemented, each of which incorporates this SAI by reference. A copy of the Prospectuses and a copy of the Annual Report to shareholders for the Funds that have completed a fiscal year are available, without charge, upon request to the address above, by telephone at the number above, or on the Trust's website at www.ProShares.com. The Financial Statements and Notes contained in the Annual Report to Shareholders for the fiscal year ended May 31, 2017 are incorporated by reference into and are deemed part of this SAI. The principal U.S. national stock exchange on which all Funds (except those noted below) identified in this SAI are listed is NYSE Arca. The S&P MidCap 400 Dividend Aristocrats ETF, the Russell 2000 Dividend Growers ETF, the ProShares MSCI Emerging Markets Dividend Growers ETF, the ProShares S&P 500 Dividend Aristocrats ETF, the ProShares MSCI EAFE Dividend Growers ETF, the MSCI Europe Dividend Growers ETF, the Morningstar Alternatives Solution ETF, the Global Listed Private Equity ETF, the Large Cap Core Plus, the High Yield—Interest Rate Hedged, the Investment Grade—Interest Rate Hedged, the Short Term USD Emerging Markets Bond ETF, the ProShares Managed Futures Strategy ETF, the Merger ETF, K-1 Free Crude Oil Strategy ETF and the CDS Short North American HY Credit ETF are listed on the Bats BZX Exchange, Inc. The UltraPro Short QQQ®, the UltraShort Nasdaq Biotechnology, the UltraPro Short Nasdaq Biotechnology, the UltraPro QQQ®, the Ultra Nasdaq Biotechnology the UltraPro Nasdaq Biotechnology and the Equities for Rising Rates ETF are listed on The NASDAQ Stock Market.
If a Fund that writes an option wishes to terminate the Fund's obligation, the Fund may effect a "closing purchase transaction." The Fund accomplishes this by buying an option of the same series as the option previously written by the Fund. The effect of the purchase is that the writer's position will be canceled by the OCC. However, a writer may not effect a closing purchase transaction after the writer has been notified of the exercise of an option. Likewise, a Fund which is the holder of an option may liquidate its position by effecting a "closing sale transaction." The Fund accomplishes this by selling an option of the same series as the option previously purchased by the Fund. There is no guarantee that either a closing purchase or a closing sale transaction can be effected. If any call or put option is not exercised or sold, the option will become worthless on its expiration date. A Fund will realize a gain (or a loss) on a closing purchase transaction with respect to a call or a put option previously written by the Fund if the premium, plus commission costs, paid by the Fund to purchase the call or put option to close the transaction is less (or greater) than the premium, less commission costs, received by the Fund on the sale of the call or the put option. The Fund also will realize a gain if a call or put option which the Fund has written lapses unexercised, because the Fund would retain the premium.
DTC may determine to discontinue providing its service with respect to Shares at any time by giving reasonable notice to the Trust and discharging its responsibilities with respect thereto under applicable law. Under such circumstances, the Trust shall take action either to find a replacement for DTC to perform its functions at a comparable cost or, if such a replacement is unavailable, to issue and deliver printed certificates representing ownership of Shares, unless the Trust makes other arrangements with respect thereto satisfactory to the Exchange. In addition, certain brokers may make a dividend reinvestment service available to their clients. Brokers offering such services may require investors to adhere to specific procedures and timetables in order to participate. Investors interested in such a service should contact their broker for availability and other necessary details.
In connection with its management of certain series of the Trust (i.e., the UltraShort S&P500®, the UltraShort QQQ®, the UltraShort Dow 30SM, the UltraShort MidCap400, the UltraShort SmallCap600, the UltraPro Short S&P500®, the UltraPro Short QQQ®, the UltraShort Basic Materials, the UltraShort Financials, the UltraShort Utilities, the UltraPro Short Nasdaq Biotechnology, the UltraPro MidCap 400, the UltraPro S&P 500®, the UltraPro QQQ®, the UltraPro Dow 30SM, the UltraPro Russell 2000, the UltraPro Nasdaq Biotechnology and the UltraPro Financial Select Sector) and the wholly owned subsidiary of each of the Managed Futures Strategy ETF, the Crude Oil Strategy ETF, the Bitcoin Futures Strategy ETF, the Short Bitcoin Futures Strategy ETF, the Blockchain/Bitcoin Strategy ETF, and the Bitcoin Futures/Equity Strategy ETF (i.e., ProShares Cayman Portfolio I, ProShares Cayman Crude Oil Portfolio, ProShares Cayman Bitcoin Futures Strategy Portfolio ProShares Cayman Short Bitcoin Futures Strategy Portfolio, ProShares Cayman Bitcoin Futures/Equity Strategy Portfolio and ProShares Cayman Bitcoin/Blockchain Strategy Portfolio, respectively) (collectively, the "Commodity Pools") the Advisor has registered as a commodity pool operator (a "CPO") and the Commodity Pools are commodity pools under the Commodity Exchange Act (the "CEA"). Accordingly, the Advisor is subject to registration and regulation as a CPO under the CEA, and must comply with various regulatory requirements under the CEA and the rules and regulations of the CFTC and the National Futures Association ("NFA"), including investor protection requirements, antifraud provisions, disclosure requirements and reporting and recordkeeping requirements. The Advisor is also subject to periodic inspections and audits by the CFTC and NFA. Compliance with these regulatory requirements could adversely affect the Commodity Pools' total return. In this regard, any further amendment to the CEA or its related regulations that subject the Advisor or the Commodity Pools to additional regulation may have adverse impacts on the Commodity Pools' operations and expenses.
The foregoing discussion is primarily a summary of certain U.S. federal income tax consequences of investing in a Fund based on the law in effect as of the date of this SAI. The discussion does not address in detail special tax rules applicable to certain classes of investors, such as, among others, IRAs and other retirement plans, tax-exempt entities, foreign investors, insurance companies, banks and other financial institutions, and investors making in-kind contributions to a Fund. Such shareholders may be subject to U.S. tax rules that differ significantly from those summarized above. You should consult your tax advisor for more information about your own tax situation, including possible other federal, state, local and, where applicable, foreign tax consequences of investing in a Fund.
Securities (including short-term securities) and other assets are generally valued at their market value using information provided by a pricing service or market quotations. Short-term securities are valued on the basis of amortized cost or based on market prices. Futures contracts and options on securities, indexes and futures contracts are generally valued at their last sale price prior to the time at which the NAV per share of a class of shares of a Fund is determined. Alternatively, fair valuation procedures as described below may be applied if deemed more appropriate. Routine valuation of certain other derivatives is performed using procedures approved by the Board of Trustees.
• Theft, loss or destruction. Transacting on a blockchain depends in part specifically on the use of cryptographic keys that are required to access a user's account (or "wallet"). The theft, loss or destruction of these keys impairs the value of ownership claims users have over the relevant assets being represented by the ledger (whether "smart contracts," securities, currency or other digital assets). The theft, loss or destruction of private or public keys needed to transact on a blockchain could also adversely affect a blockchain company's business or operations if it were dependent on the ledger.
The Fund generally does not expect to invest directly in futures contracts, option contracts and swap agreements ("Bitcoin Instruments"). The Fund expects to gain exposure to these investments by investing a portion of its assets in the ProShares Cayman Bitcoin/Blockchain Strategy Portfolio, a wholly-owned subsidiary of the Fund organized under the laws of the Cayman Islands (the "Subsidiary"). The Subsidiary is advised by ProShare Advisors, the Fund's investment advisor, and invests directly in Bitcoin Instruments. Unlike the Fund, the Subsidiary is not an investment company registered under the Investment Company Act of 1940, as amended (the "1940 Act"). The Fund's investment in the Subsidiary is intended to provide the Fund with exposure to commodity markets related to bitcoin in accordance with applicable rules and regulations. The Fund will invest up to 25% of its total assets in the Subsidiary. Except as otherwise noted, references to the Fund's investment strategies and risks include the investment strategies and risks of the Subsidiary.
The Funds may invest in the securities of other investment companies, including exchange-traded funds (ETFs) and unit investment trusts (UITs), to the extent that such an investment would be consistent with the requirements of the 1940 Act or any exemptive order issued by the SEC. If a Fund invests in, and thus, is a shareholder of, another investment company, the Fund's shareholders will indirectly bear the Fund's proportionate share of the fees and expenses paid by such other investment company, including advisory fees, in addition to both the management fees payable directly by the Fund to the Fund's own investment adviser and the other expenses that the Fund bears directly in connection with the Fund's own operations.
Another huge pain point for institutional investors is portfolio management. Investors face major difficulties in tracking their real time and historical P&L (profits & loss). Our PMS (Portfolio Management System) allows users to see real-time and historical P&L over any time interval, as well as perform real-time monitoring of positions across exchanges and wallets.
Market conditions should be considered favorable to a Fund when such conditions make it more likely that the value of an investment in that Fund will increase. Market conditions should be considered adverse to a Fund when such conditions make it more likely that the value of an investment in that Fund will decrease. For example, market conditions that cause the level of the S&P 500® to rise are considered "favorable" to the Ultra S&P500® and are considered "adverse" to the Short S&P500®.
Cardano (ADA) is a fully open-source, decentralized, public blockchain and cryptocurrency. Cardano is very similar to Ethereum, and the team wants to build on that. Cardano aims to operate a global smart-contract platform which will deliver much more advanced features compared to its competitors. Loads of existing investors are excited because Cardano is the first blockchain founded on scientific philosophy, and also the very first provably secure proof of stake algorithm.
Now, what if the Bitcoin price is rising? For example, if 1 BTC is worth 5,500 USD, you don't want to fulfill this contract any more and sell cheap for 5,000 USD. In order to still make things fair for both participants, the exchange (here CME) will make sure that you can sell for the current market price of 5,500 USD if you so wish, but they will compensate your contract partner for this. How? They will take the difference – 500 USD – out of your so-called margin account and give it to Mortimer. This kind of settlement is not only performed on the fulfilment date of the futures contract, but on every trading day, according to the current price of the asset.


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