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Dog Walking in Central Boulder, Boulder, CO
Book a dog walker to give your dog a 30-minute walk around your neighborhood.
Let's get outside and explore!
Crossroads, Boulder, CO, 80302
House Sitting, Drop-In Visits, Dog Walking
"Jenna is awesome ! We feel so lucky we found her . She so reliable and great with Obi . The pictures she takes if him are a highlight to our days . Obi loves... (more)"
Flexible Schedule, Love Dogs!
North Boulder, Boulder, CO, 80304
Drop-In Visits, Dog Walking
"Sarah took on a super-last second request for a dog walk when I was in urgent need for one, and we are so grateful for her help! It's super clear she's a pro... (more)"
One of a kind? One of the pack.
South Boulder, Boulder, CO, 80306
Drop-In Visits, Dog Walking
"Skye was willing to jump in with short notice when our regular walker was out of town and I was on a trip across the country. She sent great pics of our pups... (more)"
Active animal-loving couple
Central Boulder, Boulder, CO, 80302
House Sitting, Drop-In Visits, Dog Walking
"Meghan & Callan took care of our dog and three chickens for almost a week. They were amazing !! Great communication, they love animals, very reliable. I w... (more)"
Home full time, large park, runner.
Crossroads, Boulder, CO, 80301
Dog Boarding, Drop-In Visits, Doggy Day Care, Dog Walking
"Alex was super communicative and easy to work with! Ziggy had a great time going to the park and Alex made sure to send picture updates. I highly recommend u... (more)"
I believe our dogs are family.
Central Boulder, Boulder, CO, 80302
Drop-In Visits, Dog Walking
"Ingrid was a huge help during a stressful week. She was very patient with our shy dog, and always sent a text after each walk to let us know how it went. Rel... (more)"
My husky loves new dog friends!
Central Boulder, Boulder, CO, 80302
Drop-In Visits, Dog Walking
"MC has been walking my pup Hector for several weeks now. She has been incredibly reliable, flexible, and communicative. She walks and runs with Hector, and h... (more)"
Experienced and loves all animals
Colorado University, Boulder, CO, 80310
House Sitting, Drop-In Visits, Dog Walking
"Merideth was fantastic! She responded very quickly to texts, was clearly very comfortable and confident with dogs, and she sent me updates, pics and videos ... (more)"
Dog loving student at your service!
South Boulder, Boulder, CO, 80305
House Sitting, Drop-In Visits, Dog Walking
"Beth did a wonderful job with our silky terrier. She asked all the right questions about how he likes to be petted, handled, walked, etc... She sat him in ... (more)"
I love to run!
Central Boulder, Boulder, CO, 80302
Drop-In Visits, Doggy Day Care, Dog Walking
"We were very happy with Laurette as a sitter for our pup— truly loves dogs, takes her out on trails, and is very prompt with communication. We'll definitely ... (more)"
I'm great with all kinds of animals
South Boulder, Boulder, CO, 80305
Dog Boarding, House Sitting, Drop-In Visits, Doggy Day Care, Dog Walking
"Paola is amazing! Super nice, reliable, and great with my dog. I couldn't be happier with our experience with her. Highly recommended. (more)"
Walks and boarding! Boulder
Central Boulder, Boulder, CO, 80301
Drop-In Visits, Dog Walking
"Lauren is wonderful and very thoughtful of my dog's age and needs! I appreciate the detail she put into her walk summary and all the pictures. (more)"
Dog lover, walker, feeder, scooper!
Colorado University, Boulder, CO, 80303
Dog Boarding, House Sitting, Drop-In Visits, Dog Walking
"Michaela is a great walker. She arrives a few minutes early rather than a few minutes late and Duke is thrilled to see her. She texts photos and is a good co... (more)"
Dogs are people too.
Southeast Boulder, Boulder, CO, 80303
House Sitting, Drop-In Visits, Dog Walking
"Mimi was great with our new puppy and would even help him settle in his kennel with his separation anxiety. She was very knowledgable with doggie needs and ... (more)"
Instant friend of mans best friend
Crossroads, Boulder, CO, 80302
Dog Boarding, House Sitting, Drop-In Visits, Dog Walking
"Max jumped in at the last minute and was a total delight to work with. My pup was well taken care of, I'll definitely be calling on him again! (more)"
All the love and all the pets!
Southeast Boulder, Boulder, CO, 80303
House Sitting, Drop-In Visits, Dog Walking
"Your dog is undoubtedly considered a member of your family. So you need to be assured that he or she will be cared for by someone trustworthy... someone you ... (more)"
outdoorsy&flexible - treats&hikes
Central Boulder, Boulder, CO, 80302
Dog Boarding, Doggy Day Care, Dog Walking
"Sanjay is amazing with all dogs: big, small, young, and old! My high energy dog loved him, Sanjay walked him twice a day and followed my meal directions perf... (more)"
Professional Quality Dog-Sitter
North Boulder, Boulder, CO, 80304
Dog Boarding, House Sitting, Drop-In Visits, Dog Walking
"Jill is awesome!!! She's super friendly, clearly an animal lover, and extra responsible! Jill is a wonderful communicator. She always provides proactive upda... (more)"
i want to hang out with your pets!
Southeast Boulder, Boulder, CO, 80303
House Sitting, Drop-In Visits, Dog Walking
"Kaitlin is wonderful. She checked in every day and was very responsive. Highly recommend. (more)"
Fun-loving, responsible, & playful
Central Boulder, Boulder, CO, 80302
House Sitting, Drop-In Visits, Dog Walking
"Maggie does a great job walking Milo while I am at work. I trust her because I can tell she loves dogs and will be vigilant and caring with Milo. Plus, Milo ... (more)"
Rover also offers dog walking in these other Boulder neighborhoods:
|Colorado University
|East Boulder
|North Boulder
|Palo Park
|South Boulder
|Southeast Boulder
We know you can't always be there, and it's our goal is to connect you with walkers in your neighborhood who can help take care of your pet. With Rover, it's easy to find and book Central Boulder dog walkers who will give your dog the exercise they need. Book a 30-minute walk one day, once a week, or even every day. That way, you can take care of what you need to do and know your dog is getting the love they deserve. No matter how often you need a walker or dog walker, we're here for you. We're proud to offer complimentary premium insurance with dog walking services booked through Rover. The next time you're looking for a dog walker in Central Boulder, visit Rover to search for the perfect dog walker, set up a Meet & Greet, and book a walk anytime you need it. All you have to do after that is sit back and relax: your dog's in good hands.
A Daily Treat: A Blog by Rover
Rover's got you covered, even when you don't need a dog sitter or dog walker. Check out our blog for pictures of adorable dogs, help on your biggest dog-related questions, and more:
- Top 100 Dog Names and Unique Dog Names, depending on your preference
- 6 Rabies Facts All Dog Owners Should Know
- 10 Emoji Every Dog Lover Needs
Book a Stay, Donate to a Cause
Sit a Dog, Save a Life lets you raise money for local dogs-in-need by doing something you do already: asking your neighbors to watch your dog instead of leaving them in a kennel. Many Rover walkers in Central Boulder, Boulder donate a percentage of their earnings to nonprofits through Sit a Dog, Save a Life. When you book with a walker who has the Rover Donation Badge on their profile, you're helping dogs in need, right here in Boulder.
We're proud to support over 200 organizations across the nation, including:


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Europe wants mixed cover for satellite system
The European Union (EU) is today likely to take the next step towards setting up a global satellite navigation system for which commercial (re)insurers would almost certainly be unwilling to
More on Regulation
Insurance Charities Awareness Week is here!
Here's some members from our fantastic marketing committee showing their support for Awareness Week 2019! #ICAW #awareness #charity #support #insuranceindustry pic.twitter.com/mNjLEdqgsW— Insurance Charities (@InsCharities) June 17, 2019
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Public Lab is an open neighborhood which collaboratively develops accessible, open source, Do-It-Yourself technologies for investigating local environmental health and justice points. Use your personal personal dumpster to complete indoor and outside junk removal, or have one useful when you are patchy the roof. By reducing disposal value via environment friendly recycling we will move the financial savings on to you - our valued buyer! It is also against FLA DOT rules to hold overloaded or overweight dumpsters. Select properly and you'll cut back the costs of running your undertaking, Rent a Construction Dumpster in Marshfield, MA western MA not only supply reasonably priced costs but additionally quality providers. After they ask me to depart I'll politely ask if I can keep what I've boxed up up to now. With all kinds of sizes obtainable, every business can get what they need that best suits the extent of their undertaking. Typical Pricing for 15 cubic yards hauled off from a leading trash hauler $575-600. Our dumpsters all feature an EZ load door on the rear that swings out for simple loading. The final time I was at the recycle depot at 2nd & Gilman I discovered they had been doing a pilot program to simply accept #5 yogurt containers. The containers sit straight on the bottom; if you wish to shield your drive it's essential to present and place picket planks or plywood to sit down the container on. These containers aren't as driveway safe like 2 DUMP IT Rubber Drained Dumpsters. Containers are delivered weekdays between 6:00 AM and a pair of:00 PM. Soonest supply time after we receive the completed Damage Release Type and any mandatory documentation is the next business day for the smaller front load containers and two business days for the roll-off containers. The Residence Chemical Collection Facilities settle for these hazard sorts of waste that you simply can't put in a dumpster, together with full fluorescent light bulbs, pesticides, pool chemicals, oil-primarily based paints, solvents, and electronic waste, as well as propane and oxygen tanks. These dumpsters are used for non permanent service for bigger family projects and cleanouts. After selecting an organization, it's essential to put together the world the place your roll off container can be positioned. The primary order of business is describing the undertaking to the Sterling Heights Rent a Construction Dumpster in Marshfield, MA firm. Figuring that out will help you start with confidence, and keep reading for some suggestions that can help you keep going. It shows the hauling firm delivering and choosing up the dumpster without causing any harm to the property. Cleaning and decluttering for fall or the holidays is considerably easier and rather a lot much less difficult with the assistance of roll off dumpster firm. In case you consider you'll want the dumpster for an additional week or more, make sure to say that; charges might change primarily based on a longer time frame. Nonetheless , it's best that you simply retain the dumpster until a short while after your undertaking is completed. Your Geographical Area - prices will fluctuate from one part of Canyon Lake to a different, the place you reside can have a direct affect on your closing worth. The 1920s noticed the primary open-topped trucks being used, but as a result of foul odors and waste falling from the again, covered automobiles soon turned more widespread.
Dumpsters are available in all styles and sizes, making some higher than others for certain tasks. Traditional aerial mapping yields a flat, one-dimensional line map that shows elevations of topographical options; digital photogrammetry, nevertheless, shows an x and y location on each point, in response to Doug Isbell, director of solid waste companies, Black & Veatch, Phoenix. Renting a dumpster isn't a typical every day activity so anyone you understand who could have rented one previously will most probably bear in mind the name of the corporate they labored with. Schedule a date for supply of a brief trash or development dumpster to your house, job website, or office. Take into account any low-hanging wires, bushes or porches that could be in the space earlier than deciding the place to place your dumpster. With sizes ranging from 1 to eight yards, entrance- and rear-loading dumpsters are used to service each business and residential waste elimination wants. You'll want to be sure that the dumpster operation doesn't have impact over the aesthetics of your property or yard. You'll want to select a service, which may arrive to your property on time to empty the dumpster. During a week with a City holiday your bulk collection would be the same day as your second choose-up. Use your personal personal dumpster to complete indoor and outdoor junk elimination, or have one handy when you're patchy the roof. By decreasing disposal value via environment friendly recycling we can go the savings on to you - our valued customer! They typically value round $30.00 and are thought-about disposable; you won't get it back after it gets hauled away. While you contract with Randy's Environmental Companies to your development or demolition venture, Randy's gives for the supply and elimination of dumpsters and Roll-off boxes. To stop this kind failure, it is suggested to clear the area around the dumpster location. Dumpster Allow Apply for a permit to place a dumpster or particles container on a sidewalk or road. As Doyle's trash breaks down, it can release water that filters to the landfill's backside. While you contact how a lot does a dumpster value to hire firms in Minden, ask them how long their durations are. We can both come to you with our dumpster or you possibly can come to one in all our two places in Lansdowne, PA or Darby, PA. We expect it may very well be the simple load door Every Sam's Rent a Construction Dumpster in Marshfield includes a vertical container with a hinged door at the entrance. You might be allowed to throw glass, siding, roof shingles, lumber, drywall, tile and flooring into our roll off containers. Despite the fact that it is that simple I am still going to go into depth with this guide as a result of I know that simple logic isn't what's holding you back from the dumpster. It will be no great surprise to be taught that the smaller the dumpster, the lower the price of renting it. Nevertheless, you should be wary of renting too small a dumpster, given the potential need for repeat refills which can necessitate a longer rental period. Whether or not you need it for a large development website or demolition of your complete house, that is the best option there may be. We all know that demolitions carry giant quantities of heavy particles so we'll strive to help you select the dumpster which fits all of your wants.
Residents paying for metropolis-provided stable waste services can schedule a free curbside recycling and/or trash bulk assortment every six weeks. Statewide, Idaho averages about $20.00 per ton of waste whereas Massachusetts averages $one hundred ten.00 per ton. Premiums differ extensively from 5% to 15% of the cost of the rental, so when comparing rental costs it's a must to know if injury/loss safety is included. Within the occasion you only want to wash out a room or two, then you definately definitely could want to select a 10-yard dumpster. Our superior roll off service in Tolleson AZ utilizes large containers to haul all forms of non-hazardous Tolleson stable waste, Tolleson development, Tolleson demolition and Tolleson panorama materials. One useful technique is to attempt to scale back the burden, quantity, and odor of the trash that your camp generates. You'll probably discover a minimum of one factor you thought was protected to toss, but is on the listing of frequent family hazardous waste materials. As well as, these accidents cannot only be life threatening but can price companies a variety of time and money. If your facility is unstaffed and data are restricted, per capita waste disposal could also be used. A variety of other heavy-responsibility services are also out there for purchasers that generate large volumes of waste. The 30 yard dumpster can hold 10-12 pick up truck masses and roughly four tons weight limit. Make your spring cleansing easy, price-environment friendly and convenient with Millennium Waste's roll-off Rent a Construction Dumpster in Marshfield, MA service. Rainwater will have an effect on the burden of the container particularly if the container is filled with absorbent materials akin to dry wall, carpet, or mattresses. While 10 yard bins are amongst the most reasonably priced options when it comes to upfront pricing, they can get a bit costly when you surpass the burden allowance set by the rental company. When renting a dumpster, for either a residential or industrial challenge, prices can differ substantially. Renovating or doing a development in your house will at all times requires a dumpster to have the ability to put away all of the debris and waste. Earlier than diving into this information to dumpster diving let me present you why you'd have any need to dive into a dumpster. When you've got one of these jobs in your mind, then you definately perceive it's time to search for a trusted how a lot does a dumpster price to lease service in Berryville. Click on on the picture throughout your ordering course of to get a better view of the dimensions you're looking at. The images that seem depict the volume of each dumpster and dimensions could differ relying on which dumpster you choose. We all know you might have associates or employees to help you, your Rent a Construction Dumpster in Marshfield, MA will probably be on time every time! One other factor to contemplate when renting a roll off is to know whether it is permitted in your area since this container is massive. Per one cubic yard so there is a risk that there could also be an overweight fee for any additional weight added to your container. It may be a good idea to double examine along with your selected Rent a Construction Dumpster in Marshfield, MA service or Norfolk Public Works to make sure. A 60-watt incandescent bulb generates the identical amount of sunshine as a 15-watt fluorescent. In case you are about to embark on a major rework of your property or begin a big development challenge, you will have a roll-off dumpster. Understanding points associated to the burden of your dumpster may help you save money and time. The 12 cubic yard container is ideal for renovating a small room, cleansing up the yard after a delicate" wind storm, patching a portion of the roof or tearing out the previous again deck. Many Rent a Construction Dumpster in Marshfield, MA services embody landfill fees in their rental costs, but some do not. It is cheaper to increase the rental time than to lease a brand new dumpster to finish the job. If a container is to be used for recycling, any contamination by non-recyclables will result within the load being billed as garbage. Use our Dumpster Rental Zip Code Finder , or name us Toll-Free at 877-883-1803 to get current availability and pricing information. Roll-offs sometimes begin at 10 cubic yards, so should you only have three-four yards of waste, you might be paying for a lot more dumpster than you want. Service Stage Adjustments - To regulate container sizes and/or frequency of assortment, name the Basic Companies Department, Stable Waste Division, at (940) 668-4551. However it may be less expensive to lease a higher capability dumpster slightly than overloading a smaller container.
Please use the form below to contact us. We look forward to working with you and will get back to you as soon as possible. All fields are required


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Early evaluation of two-phase flow cycle performances with Simcenter AmesimWhen speaking about the performances of a two-phase flow system like a heat pump, dynamic system simulation is a great tool. Simcenter Amesim has a set of built-in demonstrators about refrigerant Rankine cycles and heat pumps. A first step to create such a simulation model is to predesign the desired cycle and check its performances. Let us [...] 0
FLoEFD Heat Exchanger Design for Performance – Demonstration VideoSimcenter FLoEFD is a front-loading CFD that is fully embedded in the most Popular CAD programs such a Siemens NX, PTC CREO, CATIA V5 and integrate with your CAD geometry. In this video we'll be looking at a radiator which can be found in many automotive applications. Want to receive content like this directly to [...] 0
Optimize energy strategy for hybrid vehicle with Simcenter AmesimIn the context of the launch of Simcenter Amesim, we've created a set of "how to" movies, aiming at introducing you with our latest capabilities. These short, step-by-step video tutorials, created together with our engineering team, will make you discover how you can use it, and for which purpose. Watch this video on hybrid vehicles. [...] 0
Automatic Pipeline Creation and OptimizationSee how FloMASTER can be used to automatically generate a pipeline model using geographic data and then also used to optimize your pipeline design. This presentation will also cover simulation methods for evaluating pumping station location followed by a case study analysis of a transient pressure surge. Sign up to our newsletter hbspt.forms.create({ portalId: "2847132", [...] 0
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Bushwick Bill terrified a vice president's wife into regulating song lyrics, released album art of himself bleeding on a gurney with a gunshot wound to the eye, and helped put Houston into the global hip-hop archipelago.
The 52-year-old rapper, born Richard Stephen Shaw, died Sunday in Colorado, according to
"People want to hear what's going on around them in everyday life — war, blood, violence,"
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Music Entertainment Geto Boys' Bushwick Bill dies: Morbid, provocative — an unlikely hip-hop legend Bushwick Bill of Geto Boys performs during the Beach Goth Festival at Los Angeles State Historic Park on Aug. 5, 2018. (Scott Dudelson / Getty Images) Bushwick Bill terrified a vice president's wife into regulating song lyrics, released album art of himself bleeding on a gurney...The Los Angeles Times 2019-06-11
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Sensi Hotel
Sensi Hotel
Triq Il Mahsel
Marsaskala Malta
Rated 75 / 100 based on 14 customer reviews.
The quality of service and hospitality at Sensi Hotel has been identified as outstanding based on consistently high customer review ratings.
The customer review score on Gohotels is calculated using a proprietary algorithm to determine an overall customer rating between 0 and 100. Multiple factors such as cleanliness, facilities, location and service are considered.
Properties with a customer review score in excess of 75 / 100 are presented with an Outstanding Service Award.
Sensi Hotel has achieved a score of 75 / 100 based on 14 customer reviews and has therefore qualified to receive an Outstanding Service Award from Go Hotels.
If you own or represent this business click click
to learn more about this award and how it can benefit your business.
Situated on the bay, Sensi Hotel is a great choice for a stay in Marsaskala. After having fun at the outdoor pool, you can grab a bite to eat at the restaurant or unwind with a drink at the bar / lounge. A beach bar and a poolside bar are other highlights, and rooms at this Art Deco hotel offer up nice touches like Tempur-Pedic beds with premium linens.
Facilities @ Sensi Hotel include:
Cable / Satellite TV
En suite
Private Bathroom
Private Toilet
Show Map


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PhotographVariousFunctions Slideshows Just How To Make Your Own Slideshow
A picture slide show is actually a fantastic method to keep your moments. If you don't recognize just how to create your own slideshow, I have actually mapped out some suggestions for you to follow.
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Since the witty minds of some of the leading ethnocratic demagogues and their fascistoid comrades are trying to push through a new preamble to our constitution (filled with things like "our common Christian values", "preserving the Latvian people through the centuries" and other similar primordial and often anti-democratic, regressive quackeries), I have a humble suggestion.
Why not take a few steps further, since we are in a hurry anyway? I think on this high-speed train towards "the pure Latvian state for Latvians", we could have a better use of a following text. It is much more deeply rooted in our common European history, and is inspired by some great and successful leaders who tried to preserve and defend their nation the best they could.
Or do you have any objections? I would like to hear how they sound.
We, the people of Latvia, hereby openly admit, that the institution that has so far been erroneously called the State generally classifies people only into two groups: citizens and aliens. Citizens are all those who possess full civic rights, either by reason of their birth or by an act of naturalization. Aliens are those who enjoy the same rights in some other State. Between these two categories there are certain beings who resemble a sort of meteoric phenomena. They are people who have no citizenship in any State and consequently no civic rights anywhere.
We, the people of Latvia, have come to a common conclusion. We realize fully that nobody likes to hear these things. But it would be difficult to find anything more illogical or more insane than our contemporary situation, which has subjugated us into serfdom for far too long.
Therefore we have decided that, according to the eternal will of our nation, there will from now on be a People's State which will classify its population in three groups: Citizens, subjects of the State, and aliens.
The principle is that birth within the confines of the State gives only the status of a subject. It does not carry with it the right to fill any position under the State or to participate in political life, such as taking an active or passive part in elections. Another principle is that the race and nationality of every subject of the State will have to be proved. A subject is at any time free to cease being a subject and to become a citizen of that country to which he belongs in virtue of his nationality. The only difference between an alien and a subject of the State is that the former is a citizen of another country.
The young boy or girl who is of Latvian nationality and is a subject of the Latvian State is bound to complete the period of school education which is obligatory for every Latvian. Thereby he submits to the system of training which will make him conscious of his race and a member of the folk-community. Then he has to fulfil all those requirements laid down by the State in regard to physical training after he has left school; and finally he enters the army. The training in the army is of a general kind. It must be given to each individual Latvian and will render him competent to fulfil the physical and mental requirements of military service. The rights of citizenship shall be conferred on every young man whose health and character have been certified as good, after having completed his period of military service. This act of inauguration in citizenship shall be a solemn ceremony. And the diploma conferring the rights of citizenship will be preserved by the young man as the most precious testimonial of his whole life. It entitles him to exercise all the rights of a citizen and to enjoy all the privileges attached thereto. For the State must draw a sharp line of distinction between those who, as members of the nation, are the foundation and the support of its existence and greatness, and those who are domiciled in the State simply as earners of their livelihood there.
On the occasion of conferring a diploma of citizenship the new citizen must take a solemn oath of loyalty to the national community and the State. This diploma must be a bond which unites together all the various classes and sections of the nation. It shall be a greater honour to be a citizen of this State, even as a street-sweeper, than to be the King of a foreign State.
The citizen has privileges which are not accorded to the alien. He is the master in the State. But this high honour has also its obligations. Those who show themselves without personal honour or character, or common criminals, or traitors to the fatherland, can at any time be deprived of the rights of citizenship. Therewith they become merely subjects of the State.
The Latvian girl is a subject of the State but will become a citizen when she marries. At the same time those women who earn their livelihood independently have the right to acquire citizenship if they are Latvian subjects.
After this has been carefully noted and recognized as fundamental and irrevocable truth, the People of Latvia have adopted, through their freely elected Constitutional (Satversme) Assembly, the following Constitution.


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Mr & Mrs Turner, Dorset
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Cirrhosis clinical trials at UC Health
16 in progress, 9 open to eligible people
A 5-year Longitudinal Observational Study of Patients With Primary Biliary Cholangitis
open to eligible people ages 18 years and up
This is a 5-year, longitudinal, observational study of patients with PBC designed to specifically address important clinical questions that remain incompletely answered from registration trials. In addition to the study database, a bio specimen repository will also be included so that translational studies of genomics and biomarkers of response may be performed.
at UC Davis
A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Liver Cirrhosis
open to eligible people ages 18-75
This is a study of experimental medication BMS-986036 given to adults with Nonalcoholic Steatohepatitis (NASH; the buildup of fat and inflammation in the liver that is not caused by alcohol) and liver cirrhosis (liver damage characterized by normal liver tissue being replaced by scar tissue).
at UCSD
A Study of Experimental Obeticholic Acid For Primary Biliary Cholangitis (inflammation and scarring of liver bile ducts)
open to eligible people ages 18 years and up
Primary Biliary Cholangitis (PBC) is a serious, life-threatening, bile acid related liver disease of unknown cause. Without treatment, it frequently progresses to liver fibrosis and eventual cirrhosis requiring liver transplantation or resulting in death. The investigational drug, Obeticholic Acid (OCA) is a modified bile acid and FXR agonist that is derived from the primary human bile acid chenodeoxycholic acid. The key mechanisms of action of OCA, including its choleretic, anti-inflammatory, and anti-fibrotic properties, underlie its hepatoprotective effects and result in attenuation of injury and improved liver function in a cholestatic liver disease such as PBC. The study will assess the effect of OCA compared to placebo, combined with stable standard care, on clinical outcomes in PBC patients.
at UC Davis
A Study of Experimental Seladelpar in Patients With Primary Biliary Cholangitis (disease that damages the bile ducts in the liver)
"This research study measures the effectiveness and safety of Seladelpar (or MBX-8025) in treating patients with Primary Biliary Cholangitis."
open to eligible people ages 18-75
An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Seladelpar in Subjects with Primary Biliary Cholangitis (PBC)
at UC Davis
A Study of the Experimental Medicine Obeticholic Acid For Nonalcoholic Steatohepatitis (NASH) (accumulation of liver fat)
open to eligible people ages 18 years and up
The primary objective of this study is to evaluate whether obeticholic acid (OCA; INT-747) can lead to histological improvement in fibrosis with no worsening of NASH in adults with compensated cirrhosis due to NASH.
at UCSF UCSD UC Davis
Contrast-Enhanced Ultrasound Imaging in Diagnosing Liver Cancer in Patients With Cirrhosis
open to eligible people ages 21 years and up
This clinical trial studies how well contrast-enhanced ultrasound imaging works in diagnosing liver cancer in patients with cirrhosis. Diagnostic procedures, such as contrast-enhanced ultrasound imaging, may help find and diagnose liver cancer.
at UCSD
Effects of Long-Term Administration of Human Albumin in Subjects With Decompensated Cirrhosis and Ascites
open to eligible people ages 18 years and up
This is a phase 3, multicenter, randomized, controlled, parallel-group, and open-label clinical study to evaluate the efficacy of standard medical treatment (SMT) + Albutein 20% administration versus SMT alone in subjects with decompensated cirrhosis and ascites. The study population will consist of subjects being discharged after hospitalization for acute decompensation of liver cirrhosis with ascites (or with prior history of ascites requiring diuretic therapy) with or without acute-on-chronic liver failure (ACLF) at admission or during hospitalization but without ACLF at discharge.
at UCSF
Mild Hypothermia and Acute Kidney Injury in Liver Transplantation
open to eligible people ages 18 years and up
Acute kidney injury (AKI), or worsening kidney function, is a common complication after liver transplantation (20-90% in published studies). Patients who experience AKI after liver transplantation have higher mortality, increased graft loss, longer hospital and intensive care unit stays, and more progression to chronic kidney disease compared with those who do not. In this study, half of the participants will have their body temperature cooled to slightly lower than normal (mild hypothermia) for a portion of the liver transplant operation, while the other half will have their body temperature maintained at normal. The study will evaluate if mild hypothermia protects from AKI during liver transplantation.
at UCSF
Study of OCA Evaluating Pharmacokinetics and Safety in Patients With PBC and Hepatic Impairment
open to eligible people ages 18-85
This Phase 4, randomized, double-blind, placebo-controlled study will evaluate the PK and safety of OCA treatment in patients with primary biliary cholangitis (PBC) and moderate to severe hepatic impairment over a 48 week treatment period. Patients who have completed their 48-week double blind treatment period will continue double-blind treatment until all randomized patients have completed their 48-week treatment period and the database for that period is locked. An open-label extension study in which all patients receive OCA will be considered following review of blinded safety and PK data.
at UC Davis
Do you have Fatty Liver or NASH with scars and damage to the liver (cirrhosis)? Participate in a study
"We are evaluating a new investigational medicine in the treatment of NASH (Fatty Liver) cirrhosis with or without complications"
Sorry, in progress, not accepting new patients
This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of emricasan in improving event-free survival based on a composite clinical endpoint (where all-cause mortality, new decompensation events, and MELD score progression are events) in subjects with decompensated NASH cirrhosis.
at UCLA UCSF UC Davis
Emricasan, an Oral Caspase Inhibitor, in Subjects With Non-Alcoholic Steatohepatitis (NASH) Cirrhosis and Severe Portal Hypertension
Sorry, in progress, not accepting new patients
This is a multicenter, randomized, double-blind, placebo-controlled trial involving subjects with NASH cirrhosis and severe portal hypertension (defined as HVPG ≥12 mmHg as determined by the central reader assigned to this study). Upon successful screening, subjects will be randomized to receive either emricasan 50 mg BID, 25 mg BID, or 5 mg BID or matching placebo BID.
at UCSF
Navitoclax and Sorafenib Tosylate in Treating Patients With Relapsed or Refractory Solid Tumors
Sorry, not currently recruiting here
This phase I trial studies the side effects and the best dose of navitoclax when given together with sorafenib tosylate in treating patients with solid tumors that have returned (relapsed) or do not respond to treatment (refractory). Navitoclax and sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
at UC Davis
Rollover Study of Cenicriviroc for the Treatment of Liver Fibrosis in Participants With Nonalcoholic Steatohepatitis
Sorry, accepting new patients by invitation only
This rollover study will provide open-label treatment with cenicriviroc and will assess the long-term safety of continued treatment with cenicriviroc in participants who participated in the CENTAUR study 652-2-203 [NCT02217475].
at UCSD
Seladelpar (MBX-8025) in Subjects With Primary Biliary Cholangitis (PBC)
Sorry, in progress, not accepting new patients
An 8-week, dose ranging, open label, randomized, Phase 2 study with a 44-week extension, to evaluate the safety and efficacy of MBX-8025 in subjects with Primary Biliary Cholangitis (PBC) and an inadequate response to or intolerance to ursodeoxycholic acid (UDCA)
at UC Davis
Sofosbuvir Based DAA Therapy in HIV/HCV Coinfected Pre or Post Liver Transplant
Sorry, in progress, not accepting new patients
Retrospective/Prospective, open-label study using sofosbuvir based DAA therapy to treat HIV/HCV coinfected pre or post liver transplant participants
at UCSF
Study to Assess Safety and Efficacy of GKT137831 in Patients With Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid.
Sorry, in progress, not accepting new patients
The purpose of this study is to assess the safety and efficacy of GKT13783 in patients with Primary Biliary Cholangitis (PBC) who are taking a stable dose of ursodeoxycholic acid (UDCA) treatment, and have persistently high levels of a liver enzyme called Alkaline Phosphatase (ALP).
at UC Davis
Last updated:


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Heroes in a bog: The story of the first transatlantic flight
Here's a look back at Captain John Alcock and Lieutenant Arthur Whitten Brown's historic feat 100 years ago
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NEW YORK — The pilot killed when his helicopter hit the roof of a New York City skyscraper in rain and fog radioed that he was misplaced and making an attempt to get back to the heliport however couldn't find it, an official briefed on the investigation informed The Associated Press on Tuesday.
The radio calls are the clearest evidence yet that foul climate may need played a task in Monday's crash.
The individual wasn't approved to discuss the radio calls publicly due to the continued federal security investigation and spoke on situation of anonymity.
Videos posted on social media soon after the crash showed a helicopter that investigators consider is the doomed chopper pausing and hovering south of the heliport, then turning and making an erratic flight again north by way of rain and clouds.
The pilot, 58-yr-previous Tim McCormack, was not approved to fly in restricted visibility, elevating questions about why he took off in the first place.
McCormack was only licensed to fly beneath laws generally known as visual flight guidelines, which require usually good weather and clear circumstances, in response to the Federal Aviation Administration.
The principles demand at the least three miles (four.eight kilometers) of visibility and that aircraft avoid clouds for daytime flights. The visibility at the time of Monday's crash was about 1¼ miles (2 kilometers) at nearby Central Park, with low clouds blanketing the skyline.
The crash in the tightly controlled airspace of midtown Manhattan shook the 750-foot (229-meter) AXA Equitable constructing, obliterated the Agusta A109E helicopter, sparked a fireplace and compelled workplace staff to flee.
It briefly triggered reminiscences of 9/11 and fears of a terrorist assault, however authorities stated there isn't any indication the crash was deliberate.
The crash, the second in Manhattan in a month, additionally led to renewed calls for proscribing helicopter flights over the town.
U.S. Rep. Carolyn Maloney, who represents the world where McCormack crashed, stated it's "past time" for the FAA to ban "pointless helicopters" from the town's skies.
Fellow Democrat Rep. Nydia Velazquez stated she needs vacationer flights grounded. Final yr, five passengers have been killed when a sightseeing helicopter plunged into the East River .
"The risks to New Yorkers are just too high," Maloney stated.
At a Nationwide Transportation Safety Board briefing Tuesday, investigator Doug Brazy stated that McCormack had arrived at a heliport on New York Metropolis's East River after a trip carrying one passenger from nearby Westchester County.
The passenger informed…


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Diamondbacks Farm TeamsGameday ThreadsDiamondbacks NewsDiamondbacks Game ReportsFang FoodSnake EST@az_brute_squadShareTweetShareShareSnake Bytes 1/24: More to talk about. Chase field hosts the WWE Royal Rumble this Sunday. Dback's News: Diamondbacks to sign Travis SniderThe Diamondbacks have agreed to a minor-league deal with outfielder Travis Snider. The major deal we have all been waiting for! It's not evident whether it includes an invitation to MLB Spring Training. Snider Stephen Strasburg Jersey , 30, has spent eight years in the big leagues, compiling nearly two thousand plate appearances along the way. The former top prospect had some productive campaigns, but never established himself as more than a part-time player. All told, he's a .244/.311/.399 hitter in the big leagues.Diamondbacks unveil Royal Rumble Burger available @ WWE's Royal Rumble on Sunday. The burger will be available for $13, and I expect a thorough write-up and review from ISH. Allow me to introduce you to, the thiccccccness! AZ man who shot Wilcox in 1997 over Dbacks Ballpark funding brags about it at council meeting. Naman was found guilty of attempted first-degree murder, and wound up serving 12 years of a 15-year sentence and being released in 2010. And he showed up again in Arizona public debate Wednesday night, speaking against the proposed use of $150 million in Phoenix city funds for a renovation of Talking Stick Resort Arena. Around Baseball: Extending Paul Goldschmidt could be complicated for the Cardinals. Goldy smiles as he shares a handshake and photo-op with villains. Goldschmidt has already signed what turned out to be one exceptionally team-friendly extension, and as the former union representative for the D-backs, he takes particular umbrage with team owners' increasing reluctance toward spending in free agency. 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The late right-hander's wife, Brandy, explained the family's decision Wednesday after a news conference honoring the Hall's 2019 class. WASHINGTON (AP) — Not only did the 2018 Washington Nationals fail to get over the hump — despite those infamous camels — they didn't even make the postseason, let alone finally win a playoff series for the first time."It's not something you want to go through," Bryce Harper said. "You have all the hopes and aspirations to be one of the best teams in baseball in spring training. We did what we could to possibly get there, but we didn't do enough."Now the big question looming over the earlier-than-expected offseason becomes whether Harper will leave as a free agent."Nobody knows if I'm going to be back or nobody knows if I am going to be in a different uniform," the 2012 NL Rookie of the Year and 2015 NL MVP said. "If something happens, I am not afraid of change."Plenty of roster shuffling is expected for a club that finished 82-80 for second place in the NL East under rookie manager Dave Martinez after winning two consecutive division titles with the discarded Dusty Baker.Nothing will matter quite as much as what happens with Harper, who is not only one of the on-field leaders of the Nationals, he is one of the most prominent players in the entire sport.That's why the slugging outfielder, who posted team highs of 34 homers, 100 RBIs, 103 runs (tied) and 130 walks, should get a contract worth hundreds of millions of dollars, perhaps even surpassing the record for the largest deal in baseball history."With these type of deals you're talking about Anthony Rendon Jersey , you're not betting on the baseball player, you're betting on the person," general manager Mike Rizzo said. "And he's a person we'd like to have with us."A resolution to that, however it goes, would help Rizzo determine what resources he has to use toward all of the other issues that need addressing."I consider this year an anomaly," Rizzo said.A look at what else to know about the Nationals as thoughts turn to 2019:INJURIES TO BLAME?Both Rizzo and Martinez — along with some of their players — pointed to injuries as a contributing factor in the disappointing season. 1B Ryan Zimmerman, 2B Daniel Murphy, OF Adam Eaton and C Matt Wieters each played in fewer than 100 games. Key backup Howie Kendrick played in only 40. RHP Stephen Strasburg missed about a third of the season. 3B Anthony Rendon was sideline for a few weeks early on. Closer Sean Doolittle and other members of the bullpen sat out stretches, too. "We were always missing pieces," Martinez said. "As we (cleared) one hurdle, something happened."MARTINEZ'S FUTUREThere have been questions about whether Martinez will keep his job. Rizzo has been supportive, although the GM seemed to be in Baker's corner, too. "We haven't considered anything else. We think he's got a firm grasp on the clubhouse. He's doing a good job in the dugout," Rizzo said. "I think he's getting better each and every day, each and every game." As for what Martinez thinks he might do differently next season? "We're going to spend a lot more time on just the fundamentals of baseball and doing the little things," he said. "Because little things, to me Daniel Murphy Jersey , can become really big things."SCHERZER AND STRASBURG Max Scherzer's 300 strikeouts, 2.53 ERA, 220 2/3 innings and various other stats showed once again how valuable the righty is. Beyond him and Strasburg, though, there's not much there in the rotation. Washington could add at least two, maybe three, starters.SOTO AND ROBLESThe most promising news of 2018 was the discovery of 19-year-old outfielder Juan Soto, the NL Rookie of the Month in June, July and September who finished with a .292 average, 22 homers, 70 RBIs and 79 walks. Only two other teenagers (Harper was one) ever hit 20 HRs in a season. Another young outfielder, 21-year-old Victor Robles, also appears to be a keeper.SO MANY NEEDSThe Nationals must find starters at second base and catcher. They need bullpen help. They need new bench pieces.
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Investing should be easy – just buy low and sell high – but most of us have trouble following that simple advice. There are principles and strategies that may enable you to put together an investment portfolio that reflects your risk tolerance, time horizon, and goals. Understanding these principles and strategies can help you avoid some of the pitfalls that snare some investors.
Are Alternative Investments Right for You?
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Vídeos: 9
Visualizaciones: 86k
Videos Favoritos: 79.3%
Clasificación: 87.8%
Vídeos: 19
Visualizaciones: 3M
Videos Favoritos: 83.3%
Clasificación: 87.6%
Vídeos: 18
Visualizaciones: 2M
Videos Favoritos: 85.7%
Clasificación: 87.6%
Vídeos: 4
Visualizaciones: 1M
Videos Favoritos: 83.2%
Clasificación: 87.5%
Vídeos: 45
Visualizaciones: 4M
Videos Favoritos: 81.1%
Clasificación: 87.5%
Vídeos: 26
Visualizaciones: 13M
Videos Favoritos: 86.2%
Clasificación: 87.4%
Vídeos: 8
Visualizaciones: 2M
Videos Favoritos: 86%
Clasificación: 87.4%
Vídeos: 47
Visualizaciones: 6M
Videos Favoritos: 82%
Clasificación: 87.4%
Vídeos: 15
Visualizaciones: 587k
Videos Favoritos: 84.1%
Clasificación: 87.4%
Vídeos: 26
Visualizaciones: 3M
Videos Favoritos: 78.5%
Clasificación: 87.4%
Vídeos: 2
Visualizaciones: 4k
Videos Favoritos: 82.8%