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Its 3rd of June once again, my angel brother's face is once again is in my mind. Time has strange nature, when we go through some difficulties it seems to be stopped and when we're merrymaking it seems to run fast. Whatever it is whenever we recall the olden times it seems a far away memory. Memories are precious as these are our actual gains, memories we have of others and memories others have of us. The part of human nature that amazes me is the ability to be contented, yet only a few are blessed with it; it's really a cherish able ability to have. Our creator has blessed us with a mind, to think and to reason yet He has calmed our curious nature with contentment. The levels of this ability may be different among all of us but we feel contented with whatever we have at some point in time.
Its fourth year since my brother's death and I feel we have been calmed over what happened. Yes the mighty humans have many things which are not in our hands or may be we are not deemed much important to take these too, by our creator. Creation and destruction are ultimately the tasks of the power who controls all of us.


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Raising the status of Biodiversity in the Sustainable Schools Framework
Experiencing nature is being increasingly recognised as a critical element of young people's time at school. The organisations which make up the Sustainable Schools Alliance are motivated by this positive direction and believe it needs to be tied into fostering an understanding and respect for broader but interconnected sustainability issues.
The SSA first met in October 2016 to discuss the scope of producing a new doorway on Nature and Biodiversity for the Sustainable Schools Framework. Members had noted that although wildlife and nature come under the 'biodiversity cross-cutting theme' they could easily be overlooked within the current framework which doesn't offer teachers clear routes into exploring those subjects.
The fifteen SSA members are bringing their varied expertise to this collaborative piece of work for the first time, with RSPB, OASES North East and SEEd taking on particular roles. It was quickly clear that this new doorway is an opportunity to give the framework format a makeover. If this one is successful the SSA are keen review other doorways; their relevance, how to update and present them in a teacher-friendly manner.
It was exciting to recently reach the stage of holding a workshop and consultation which allowed teachers and educators to trail and feedback on the proposed new design. Read more about that here in a SEEd blog post by Ann Finlayson. The event was supported by many SSA members including Centre for Alternative Technologies, Association for Science Education and North Yorkshire County Council as well as many SEEd members and school teachers.
The Sustainable Development Goals (SDG's) which most clearly relate to nature and biodiversity were identified. This generated insightful discussion how they are being taught and acted upon, or not, in UK schools and therefore whether a Sustainable Schools Framework should be linked to SDG's?
Important conversations were held around not just how nature and biodiversity is highlighted yet embedded into learning but about how it can be monitored and seen as integral across the three C's of curriculum, campus and community. SSA member Bluewave Education presented its online school improvement management software which could include a quality framework designed for SDG's, or another set of aspects chosen to monitor this new doorway. The software allows schools to clearly see that making achievements in this framework also contributes to reaching targets and quality standards in other assessments and monitoring they must undertake.
The SSA members are looking forward to trailing this new doorway content and design with different groups over the coming months, taking on board feedback and officially launching it at the National Sustainable Schools Conference in October.

subset: commoncrawl


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5:00pm PT by Jordan Zakarin
Jessica Chastain Passes on 'Iron Man 3' Role
For Jessica Chastain to appear in the next Marvel film, she would need a supersonic flight suit that could jet her around the world in record speed. Unfortunately, those only exist in comic books -- and via special effects, movies based on comics -- so it turns out that Chastain will not be appearing in Iron Man 3.
PHOTOS: Elizabeth Olsen, Jessica Chastain Pose for 'THR'
THR has confirmed that the Oscar-nominee, who appeared in six films in 2011 alone, was offered the role of a scientist in the third go round of Marvel's most successful single hero film franchise, but has officially passed on the part.
In a note posted to her Facebook wall, she wrote, "Sorry to say that Iron Man 3 isn't going to work out. My schedule is jammed packed and I can't fit anything else in. The press announced my possible attachment far too soon. I know many of you wanted me to be involved, and I'm so sorry to disappoint you. Hopefully there'll be another Marvel film in my future. Shane Black and everyone on the IM3 team are really wonderful. I'm very excited to see the film when it comes out. xx"
Black will helm the Iron Man series for the first time, after Jon Favreau directed the first two. Robert Downey Jr. returns as the titular hero, Gwyneth Paltrow will reprise her role as his assistant and girlfriend Pepper Potts, Don Cheadle will again play Lt. Col. Rhodes. Newcomers Ben Kingsley and Guy Pearce also join the cast as well.
Jordan email@example.com @thr


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Lizard Island's new Executive Chef Anthony Healy is preparing a week-long culinary Christmas season celebration this year.
AUSTRALIA (November 15, 2012) –Lizard Island's new Executive Chef Anthony Healy is preparing a week-long culinary Christmas season celebration this year.
While guests snorkel or dive the beautiful Great Barrier Reef or simply sink their feet into the island's 24 powdery white beaches, Healy will be creating a specially designed Reveillon Christmas Eve Menu, a Christmas Day menu and a New Year's Eve menu for the festive season.
The Reveillon is a European tradition in the form of a long dinner or party usually held the night before Christmas Day. A good cause for celebration on Lizard Island, the Reveillon menu will offer 24-month aged Jamon Iberico with a celeriac paste to start, followed by organic quail and boudin noir, roast barramundi, organic duck breast and followed by apple tarte tatin. The five-course Reveillon dinner will be matched by a selection of Australian, New Zealand and French wines.
On Christmas Day, guests will be treated to a light, yet traditional, Christmas dinner offering smoked ham hock terrine, local painted crayfish, seared red emperor, slow roast Australian turkey breast and traditional Christmas pudding.
On New Year's Eve, celebrations on Lizard Island will kick off at Ospreys Restaurant with oysters and cream, matched with NV Louis Roederer Champagne, followed by Western Australian Marron, seared coral trout, eight-score Wagyu sirloin, a selection of cheeses and fresh fruit and the dessert finale - Healy's interpretation of a deconstructed Snickers bar, a layered chocolate ganache with a salted peanut butter parfait, a nougat espuma and a salted butter praline. The seven-course New Year's Eve dinner will be matched by a variety of Australian wines.
This will be Healy's first Christmas on the Island. He joined Lizard Island from Hayman Island where he was Chef de Cuisine in La Fontaine restaurant for two and a half years. He has a culinary career spanning 10 years around the world working in top restaurants in London (Les Trois Garcons), France (La Cote Saint Jacques) as well as Australia (Il Centro).
"I'm still making dishes that have a strong French influence in style and quality but I'm introducing options that are fresh and light and reflect the fact that we are on a beautiful tropical island," said Healy.
"The produce we use on Lizard Island is second to none. Our food is flown in daily, such as line-caught reef fish, local prawns, red emperor and Spanish mackerel, plus local produce from the nearby Atherton Tablelands such as beef from the rich volcanic soils of Mareeba," he said. "The choice we have of locally-grown fresh produce is fantastic and our location here on the Great Barrier Reef is no barrier to quality food."
The main pavilion on Lizard Island houses the fine dining restaurant, Ospreys, and under the direction of Healy, the restaurant's menu changes daily.
Award winning and a constant favourite in the world's 'best' lists, Lizard Island is located right on the spectacular Great Barrier Reef, 240km north of Cairns and 27km off the coast of Cape Flattery. An idyllic island fringed with pristine coral reefs, crystal clear waters and 24 powdery white beaches, Lizard offers the postcard perfect setting for an Australian island escape.
Editors Note:
Lizard Island is owned and operated by Delaware North Australia Parks & Resorts, owners of Australian resorts including Wilson Island, El Questro Wilderness Park, Heron Island and Kings Canyon Resort.
For more information on bookings and special offers go to: www.lizardisland.com.au
For reservations contact: 1300 863 241 or +61 3 9413 6297.
Media Contact:
Jill Collins
Barking Owl Communications
Email: email@example.com
Louise Longman
Longman Communications
Email: firstname.lastname@example.com


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Wednesday, September 12, 2012
A Sad Day for the Foreign Service
My thoughts and my heart go out to the friends, family, and other loved ones of the four Americans who lost their lives in Benghazi last night.
A colleague recently described the U.S. government's position on free speech in a way that really resonated with me: we are "extremists when it comes to free speech." We might distance ourselves from what you have to say, we might even call your words reprehensible and a few other things, but we will continually defend your right to say it. Someone in America put up some video, which I understand says some wild and offensive things (I confess I haven't seen it myself), and someone in Egypt thought it was a good idea to put clips of that video on television and tell people to go to the U.S. embassy and protest. The jury is out as to whether the tragic events in Benghazi are related to that whole mess or not, but at the end of the day, freedom of speech protects what those people said. We'll certainly distance ourselves from both the video and the person who called people to protest at the embassy about it, but we'll defend their rights to say it.
As for my own opinions, suffice it to say I've got some choice words for those who would perpetrate this kind of attack, and for those in this country who would try to turn a tragedy like this into a political football. In the interest of civility, I'll keep those words to myself for now, as I fear I would veer into expletives territory. Instead, I'll share with you a bit of Secretary Clinton's eloquence from earlier today:
"All over the world, every day, America's diplomats and development experts risk their lives in the service of our country and our values, because they believe that the United States must be a force for peace and progress in the world, that these aspirations are worth striving and sacrificing for. Alongside our men and women in uniform, they represent the best traditions of a bold and generous nation."
"Some have sought to justify this vicious behavior, along with the protest that took place at our Embassy in Cairo yesterday, as a response to inflammatory material posted on the internet. America's commitment to religious tolerance goes back to the very beginning of our nation. But let me be clear – there is no justification for this, none. Violence like this is no way to honor religion or faith. And as long as there are those who would take innocent life in the name of God, the world will never know a true and lasting peace."
May it be a long, long, long time before we ever wake up to news like this again. Ideally, we never will, but being a part of the modern Foreign Service means we all serve – or will serve – in difficult places and in harm's way.


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One hour to discuss anything you want, through the eyes of Astrology and Vedic wisdom.
We'll have a video call via Zoom (a lot like Skype but better) on a date and time that works for the both of us. Depending on how busy and how compatible our schedules are, our appointment may wind up being a few weeks or months down the road.
I'll contact you within a day or two to set up our appointment, touch base, and hear where you are at.
Fee: $306 (PayPal can convert to your local currency)


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Fallout 4 - AMD vs Nvidia Performance Review
Graphical Options and Settings
Published: 11th November 2015 | Source: OC3D | Price: |
Graphical Options and Settings
The graphical options of this title will only be available to you before it launches, so sadly players will not be able to change their settings on the fly when the going gets tough. Here you will be able to change everything from the type of AA you use, how far you want the draw distance to be on certain objects all the way to whether or not you want to use features like motion blur and Ambient occlusion.
One bug I have found while using the graphical options menu is that if you use the Medium, high and ultra presets as the basis of your personalised graphical settings you will not be able to turn off Fallout 4's Godrays. If you select off it will automatically switch to low, which is a highly irritating bug given the high performance impact of the feature.
The only way to turn off God Rays at higher settings is to click on the games low presets and modify your settings from there, which is fairly time consuming when you just want to turn down Godrays.
Apart from this issue the graphical options menu is very usable, offering a wide range of details to adjust. Some of the most demanding settings will tell you that turning them down will have a large impact on performance, so users who want a higher framerate will definitely need to consider turning these settings down first.
One thing that will certainly have been noticed by many of you avid PC gamers will be that it is missing a vsync option, this game is automatically capped to 60FPS, making the game unable to support displays that are above 60Hz fully, which is a real shame.
The reason why Bethesda have decided to cap the framerate at 60FPS is the fact that the in-game physics breaks whenever your are much higher than this framerate, giving the game plenty of unique issues which hinders gameplay.
We do not recommend that you play the game with an uncapped framerate using an .ini hack or any other method, but for the purposes of delivering accurate benchmarking results we have benchmarked the game in an uncapped state, so that the comparative performance of each GPU is most noticeable.
Most Recent Comments
I installed the Nvidia update and went with the recommended settings which were "Ultra" on my GTX 980. I really appreciate your article and photos. I got a couple hours into the game and at 1440P on Ultra it was very smooth for me.
I really am going to go in and make the changes to low quality and turn god rays off eventually. Right now i wish I had a vacation day available to actually play today
Loving it so far
it would be awesome if you could add in sli/crossfire scaling for people still rocking older hardware and maybe if you got time to add in i5 vs i7?
only if you got timeQuote
Nice write up WYP, although it would be interesting to see some i5 vs i7 comparisons. Someone in a different thread reported a website benchmarking both and there were big differences between them.Quote
Am I the only one who's not seeing the article/and link in the OP?
Nice write up WYP, although it would be interesting to see some i5 vs i7 comparisons. Someone in a different thread reported a website benchmarking both and there were big differences between them.
That's at 1080p with an i7-6700k and GTX 780 where neither are overclocked.Quote


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YORK, PA - York College men's soccer freshman Antonio Bua (Lancaster, Pa./Lampeter-Strasburg) has been selected as the latest Spartan Athlete-of-the-Week for the span of November 9-15.
The Spartan rookie posted a fantastic weekend as he recorded a trio of goals, including both game-winners, in York's two victories to begin the 2009 NCAA Tournament.
Against Cazenovia in the first round, Bua began the Spartans' offensive splurge in the 12th minute as he knocked home a headerfor the match's opening score. The Green and White would go on to tally five more times in the match, including another by Bua in the 33rd minute, to secure the 6-0 victory.
In Sunday's second-round tilt with Amherst, Bua again tallied the game-winning score - this time in the 30th minute. Bua collected a short pass from Kemal Nuspahic (East Petersburg, Pa./Warwick) at the top of the box before quickly slotting York's first goal of the game into the right-side netting. Nuspahic would go on to notch the other score in the second half as the Spartans advanced with the 2-0 triumph.
Bua has registered seven goals this year, tying him for the third-highest total on the squad, as he has become one of the Spartans most dangerous attacking players.
With their two wins this weekend, the Green and White advance to the NCAA Sweet 16. The Spartans have been chosen as the host site for the sectional rounds with play beginning on Saturday, November 21. York will take on Williams while Christopher Newport will tussle with Stevens. Please visit www.ycpspartans.com for updated tournament information.
Antonio Bua photo courtesy of Zach Clabaugh (www.sharpedgephoto.smugmug.com)


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In roughly one month's time, I'll be turning 40. During odometer milestones such as these, it's difficult not to reflect on time and age, and the inherit absurdities. On the one hand, I'm too advanced in dog years to pretend to be anything other than an adult. On the other hand, I still live and behave like a college student. Last week, I pulled two all-nighters, burned the soles of my feet by carelessly walking around barefoot on hot pavement, and drew a series of penises on Scrabble tiles at a friend's birthday party. Yep, 40. And then there's that childish chasing your art dream thing… which seems more challenging with age, blistered feet, and a lack of sleep.
This past week, I also completed a new album (hence the all-nighters), and booked an event at which to celebrate the album's completion. II. Providence is the name of the album. It's the second EP (extended play album) for American Murder Song, a new project by Saar Hendelman (The Devil's Carnival co-composer) and me.
In a time where all one needs to be a star is a webcam and NPD, Saar and I have been tirelessly working to create an experience with American Murder Song that delivers more. For the past three months, we've been releasing weekly music and video content that's high-concept, high production value, and (hopefully) highly entertaining. On II. Providence—a collection of drinking songs involving murder in 1816 America—our sonic palette includes saloon piano, fifes, and, yes, inebriated group singing. A medley of the EP's songs can be heard in this trailer.
By pre-ordering II. Providence, you'll not only be acquiring a batch of "killer" tunes, but also helping to make a 2016 American Murder Song tour a reality. We want to come to your town and play songs for you this fall. All EP proceeds help fund this goal. In addition to music, we're offering a menu of cool ways that you can be a part of our tour goals. We're even auctioning ourselves for backyard performances, private Skype chats, and more. Check it out: http://americanmurdersong.com/getmusic.
To celebrate the release of II. Providence, Saar and I are also hosting a very intimate party in Los Angeles. You're invited. At the party, we'll be screening American Murder Song's very first music video, and Saar and I will be singing a live set of songs form the new album. Select members of the cast and crew will be in attendance, and we plan on having a great time. Come join us. Tickets are very limited, so reserve yours today: http://americanmurdersong.com/tickets.


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It turns out Queen Elizabeth summoned Prince Andrew to the Royal Palace after pictures of him with convicted hedge fund sex offender Jeffrey Epstein were published in the Daily Mail, according to a profile of the wayward British prince in this month's Vanity Fair.
Even though Prince Andrew -- who is the UK's Ambassador for Trade -- had embarrassed the Royal Family before, apparently remaining chummy with Epstein, who has been accused of inappropriate sexual relations with at least 30 underage girls, was what sent the Queen over the edge.
In particular, allegations made by a woman called Virginia Roberts, against Epstein and the Prince, triggered the Queen's scolding. Roberts alleges that when she was younger, Epstein flew her out to the States where she was trained as a prostitute, and that she was flown specifically to meet Andrew. The Prince says he never engaged in sexual contact with her.
According to Vanity Fair,
The sordid connection to Jeffrey Epstein inflicted by far the greatest damage on the prince's reputation. According to a sworn deposition by Juan Alessi, a former employee at Epstein's Palm Beach estate, Andrew attended naked pool parties and was treated to massages by a harem of adolescent girls. The phone call from Sian James of The [Daily] Mail... created a 36-hour maelstrom at Buckingham Palace," a royal source told me. "At some point during those 36 hours, the Queen summoned the Duke of York to a meeting." According to several well-informed individuals, the Queen was not amused.
The Queen asked Prince Andrew why he had consorted with someone like Jeffrey Epstein, whom the F.B.I. had reportedly linked to about 40 young women, most of them underage. More to the point, the Queen demanded to know if her son had any more surprises up his sleeve.
Prince Andrew swore to his mother he'd never slept with Virginia Roberts, or any of Epstein's other alleged victims.
Don't miss: An Alleged Victim Of Hedge Funder Jeffrey Epstein's Sexual Advances Tells All >


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May 12 | 4pm to 6pm
The Greenville Chamber Atrium
24 Cleveland Street, Greenville, SC 29601
Nika White Consulting is hosting a drop-in Book Signing event for The Intentional Inclusionist™ in the Greenville Chamber atrium. There will be light refreshments, books for purchase, as well as, new Intentional Inclusionist™ products like t-shirts and embossed bracelets! Checks, Credit cards/Debit cards and Cash will be accepted.
Already ordered your book through Amazon? Bring it with you to have it personally autographed and get your picture taken with Dr. White against the Intentional Inclusionist™ photo backdrop.
Stay tuned for more information about another book signing event May 31st from 5 to 7pm at Greenville Commerce Club. Can't make it to either of these two events, purchase your copy via Amazon.
If you plan to attend, please RSVP to Dr. Nika White at email@example.com by May 8, 2017.
Dr. Nika White is the author of "The Intentional Inclusionist™," which shares principles for becoming an inclusion-minded leader. The book inspired by philosophies of leadership, and inclusion contains principles and philosophies to help individuals become more intentional in how diversity and inclusion is understood and practiced at the individual level. No matter what your role—an executive, a manager, a business owner, or someone interested in seeing our world become better —you have the power to drive change and have influence in your sphere of influence.
Dr. Nika White's professional career spans about 20 years, ranging from serving as a diversity and inclusion practitioner, an accomplished marketing communications executive, economic development leader and community advocate. Dr. White found inspiration through the intersection of business, diversity and leadership, and has made this her niche. She is a national sought after consultant, thought leader, and speaker to countless organizations and executives on issues of team engagement, organizational leadership, strategic diversity, and intentional inclusion. In 2017, Dr.White launched Nika White Consulting to focus on delivering subject matter expertise in the diversity and inclusion space to organizations throughout the country. Dr. White's consulting firm serves as the Senior Advisor to the Greenville Chamber's Diversity and Inclusion initiatives and is responsible for creating and collaboratively implementing an overarching diversity strategy for the Greenville Chamber. As an extension of the executive team as a consultant, Dr. White designs and oversees initiatives that develop and promote inclusion of diverse businesses in the economic activities of Upstate South Carolina. Dr. White demonstrates her influence in the marketplace and the community with awards like SC Career Woman of the Year, SC Upstate Business Journal Who's Who, US Small Business Association's SC Minority Business Advocate of the Year, Greenville Business Magazine 50 Most Influential, and national recognition by The Network Journal Magazine as Top 40 Under 40 Leaders and Diversity MBA Magazine as Top 100 Under 50 Executives. Dr. White is the author of "The Intentional Inclusionist™" a book for leaders who desire to grow as inclusion-minded individuals and exercise their leadership to enhance the workplace, build up communities, and have a positive impact on any circle of influence to which they belong. Dr. White's book, inspired by philosophies of leadership and inclusion, contains principles to help individuals become more intentional in how diversity and inclusion is understood and practiced at the individual level. The book is designed to help leaders recognize that collective efforts one person at a time can change the way the entire world looks at human difference. Learn more at www.nikawhite.com


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Tag Archives: Publicly Traded
Why I Sold Tucows
It's hard post to write, but on Friday I sold most of my remaining shares of Tucows. Last year – before the reverse split I sold a little more than half, and just now I sold most of the rest. I invested in Tucows back in 2005 or 2006 for reasons which were admittedly, more […]… Read the rest
The Era of AAPL is Over
I got a few comments from my "Tech Pair Trade of the Century" post awhile back along the lines of "Short AAPL? Good luck!" and "Long RIM? Good luck!". So it was with interest I noted this week (13F week, when all the "big boys" file their 13-F's with the SEC) that two very large […]… Read the rest
Ultimate Buy Signal for RIM?
I have long since thought that RIM was going through an unprecedented bout of negativity which has had it on my "watch list" for months. Contrarians love this type of stock, John Templeton always tried to "buy at the point of maximum pessimism" (there is a good book by that title, and you may also […]… Read the rest
Cyberplex decimated by Yahoo/Bing and Q4 Guidance restatement
Cyberplex.com (TSX:CX) is Canada's largest CPA network with a fairly blue-chip customer base including RBC and Jaguar along with net giants like eHarmony and Netflix. They've been pretty aggressively growing revenues and earnings over the past couple years and for awhile I counted myself a shareholder. I sold my position last year when they announced […]… Read the rest
Demand Media files amended S1
In Brief: Demand Media has filed an amended S1 to their IPO. I don't have a lot of time to look at the differences, but I thought I'd mention it for those who are interested. Could make for some interesting weekend reading.… Read the rest


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5 things to know this morning: Roseanne Barr blames her Ambien and bashes co-stars, Trump takes on Jay-Z, and Drake gets dissed
Good morning! Catch up on your pop culture news with our roundup of today's top stories — so far.
1. Roseanne Barr apologizes for "Ambien-tweeting"
Just hours after ABC canceled her show, Roseanne Barr returned to Twitter to apologize for her "unforgivable" remarks about Valerie Jarrett, an African-American woman who was an adviser to former President Barack Obama. She went on to blame the racist attack on "Ambien-tweeting" in a since-deleted tweet, and is now accusing former co-stars like Michael Fishman of "throwing me under the bus." Read more >
i created the platform for that inclusivity and you know https://t.co/hViHPX2ZUb. You throw me under the bus. nice!
— Roseanne Barr (@therealroseanne) May 30, 2018
2. Pusha-T exposes Drake's blackface photo
As far as rap feuds go, the one brewing between Pusha-T and Drake is a doozy. Pusha-T's new track, "The Story of Adidon," accuses Drake of having a secret love child and features a controversial photo that shows the Canadian rapper in blackface. Read more >
Please stop referring to this picture as "artwork"…I'm not an internet baby, I don't edit images…this is a REAL picture…these are his truths, see for yourself https://t.co/gd6vRS3HM8 pic.twitter.com/2el58HEZ8F
— King Push (@PUSHA_T) May 30, 2018
3. President Trump slams Jay-Z
Speaking of feuds, President Trump devoted a portion of his Tennessee rally Tuesday to berating Jay-Z over his "filthy" language. Pot, kettle, etc. Read more >
Pres. Trump on Jay-Z at Clinton campaign rally: "His language was so filthy it made me look like the most clean-cut human being on Earth." https://t.co/JF5NpbHdng pic.twitter.com/iaUUiTFN1N
— ABC News Politics (@ABCPolitics) May 30, 2018
4. Paris Jackson calls out "animal cruelty" at Dior
Paris Jackson has responded to reports that she "stormed out" of Dior's fashion show last week, clarifying that she quietly left because she was "heartbroken" over the treatment of horses featured in the equestrian-themed event. Read more >
furthermore, i was not 'enraged,' just taken by surprise and a little heartbroken. and i have no doubt that all high end fashion brands will soon switch over to no-fur and anti animal cruelty, as that seems to be the pattern here. and we should all be very excited about that!
— Paris-Michael K. J. (@ParisJackson) May 30, 2018
5. The Walking Dead may lose lead
And another one bites the dust. Andrew Lincoln, who plays Rick Grimes on The Walking Dead, is rumored to be leaving the zombie-centric show after Season 9. Co-star Norman Reedus will reportedly take over as the lead star. Read more >
Thanks for reading! Come back this evening for your p.m. pop culture roundup.


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I, Spy Blog Tour
About the BookCanada is probably the last place you'd expect to find an American spy. But even idyllic Ottawa has its deadly secrets—and so does CIA operative Talia Reynolds. She can climb through ventilation shafts, blend in at the occasional diplomatic function, even scale buildings (small ones). But there's one thing she can't do: tell her aerospace engineer boyfriend Danny about her Top Secret occupation. It worked for a year, keeping Danny in the dark, keeping him away from danger, keeping her secrets. And then Talia finally catches a hot case: Fyodor Timofeyev. Russian. Aerospace executive. Possible spy? She can make this work, too—until Danny needs her at the same time her country does. And when Fyodor targets Danny? Suddenly her schedule isn't the only thing suffering. Now to save her secrets and her country, Talia must sacrifice the man she loves. More about I, Spy | Add I, Spy to your Goodreads to-read list!
Advance praise
The edge-of-my-seat undercover operations kept me turning pages, and just when I thought the story would go one way, plot twists sent it down another path. Thrilling, adventurous, and romantic, this book has it all for an Alias fan.
— Jami Gold, award-winning author
Jordan McCollum's debut novel is a delightful combination of mystery, action, and romance. Talia's CIA training and almost OCD caution feed her quirky humor while exposing her very human fears and insecurities. Add in her boyfriend Danny, and it's enough to twist your heart.
— Donna K. Weaver, author of A Change of Plans
Clever, suspenseful, and charged with political intrigue and romance, I, Spy is the perfect combination for a fun and captivating read!
— Michelle Davidson Argyle, author of Monarch
My Review
About the authorAn award-winning author, Jordan McCollum can't resist a story where good defeats evil and true love conquers all. In her day job, she coerces people to do things they don't want to, elicits information and generally manipulates the people she loves most—she's a mom. Jordan holds a degree in American Studies and Linguistics from Brigham Young University. When she catches a spare minute, her hobbies include reading, knitting and music. She lives with her husband and four children in Utah.
The clue!As part of the debut of I, Spy, Jordan is hosting a contest to figure out the song that inspired the story. Collect clues at each blog stop and use your spy skills to piece together the clues to win a $25 Amazon gift card! How to enter The clue for this stop is:
The freebie!Thanks for participating in this launch tour! As a free gift this week, Jordan is giving out free copies of Mr. Nice Spy, an I, Spy prequel novella. Simply to go http://JordanMcCollum.com/store/. You can also get 40% off I, Spy!
7 comments:
Thanks so much, Cami! I'm so glad you enjoyed the books!!ReplyDeleteReplies
Thanks for sharing them with me!Delete
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The video says it's the only beer pool in the world on that scale. I sense a business opportunity here.
Gonna be honest the prospect of drinking beer that has any of my or someone else's skin cells or anything else in it.
Then what's the point in bathing in beer?
@Ilriyas said:
Then what's the point in bathing in beer?
It's supposed to be good for your skin, and it's also lulzy?
Just me, but I have a feeling you would end up smelling like a brewery for a while. Your skin would soak up the beer and retain a certain amount which I don't think would smell very good as old beer just stinks.
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This shop has been compensated by Collective Bias, Inc. and its advertiser. All opinions are mine alone. #MomsWingMan #FarmRichSnacks #CollectiveBias
If you look through my recipes on here, you'll notice a theme – I'm into quick, easy and delicious. I mean real life for me as a mom means wanting to make yummy meals for my family to sit down with, but also wanting to play and spend time with my kids and husband, and we all know there's just not enough hours in the day to do it all. Chicken and waffles are a southern staple and one of our favorite foods, and thanks to Farm Rich it's the perfect busy night meal! But it's always fun to spice things up a little bit, so my husband and I have started having spicy chicken and waffles and are huge fans.
Here's what you'll need:
-(1) Box Farm Rich Buffalo Style Breaded Chicken Wings (17 ounce) or Buffalo Style Breaded Chicken Bites (17 ounce)
-(1) Box Frozen Waffles
Here's what you'll do:
Bake Farm Rich Chicken Wings or Chicken Bites in the oven according to the directions on the box Meanwhile toast waffles according to directions. Cook half as many waffles as wings/bites you are using. Allow wings to cool 1-2 minutes when done, then toss in the buffalo sauce included in the box.
Place two wings/bites on top of each waffle. Top with a little bit of your favorite syrup to make the perfect sweet and spicy flavor, serve and enjoy! Have someone in the family that doesn't do spicy? simply take a couple wings/bites out before tossing in the sauce and have regular chicken and waffles!
I love that Farm Rich is all about making life easier for moms so that we can make every moment count and makes our days a little easier. Farm Rich makes easy, wholesome, feel-good foods that I'm happy to serve and know that my family will love.
Right now you can save big on Farm Rich at Kroger! From November 5 – November 18 buy 10 participating Farm Rich products (check the list here) and save $5! Offer valid 11/4/15 – 11/17/15 in most areas, please check your local circular for dates in your area. If Kroger is not your grocer, please go to MomsWingman.com to find your neighborhood retailer for specific ad dates and other featured products. I find Farm Rich in the frozen appetizer section of my neighborhood Kroger!
Check out more quick and easy recipes using Farm Rich on MomsWingman.com! What do you do to make busy nights a little easier for you and your family?


text: RAINS' Scout Bag is a classic yet modern daypack made from a water-resistant fabric with a matte finish. The waterproof rucksack has an inside laptop pocket, a spacious main compartment and a zipped outer pocket. Completed with carabiner details, adjustable snap buttons and adjustable webbing straps, the backpack is stylish yet practical.


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National Honor Society
"I pledge myself to uphold the high purpose of the National Honor Society to which I have been selected; I will be true to the principles of which it stands; I will be loyal to my school; I will maintain and encourage high standards of Scholarship, Service, Leadership, Citizenship, Character, and Spiritual Growth."
– Agape Chapter Pledge
OCSI's National Honor Society Agape Chapter, an official member chapter of the nationwide NHS program, is a group of students who are dedicated to providing an example of leadership and service to their fellow students. High school students wishing to join must meet a certain grade point average qualification and must submit an application to be reviewed by a committee of teachers. OCSI's NHS is supervised by a faculty adviser and overseen by its own internally elected officers. It meets on a weekly basis to discuss service activity opportunities, and to plan and organize events. The group is called upon by the school to assist in many large school functions and remains available to serve faculty and staff in any useful capacity when requested. As members of the Agape Chapter of the National Honor Society, students in the group are required to abide by the rules of membership laid out in the Society handbook and conduct themselves in an exemplary manner in and out of school.
There are a number of scheduled school events with which OCSI's NHS chapter is expected to assist. Those events can be found on the calendar below. Other events, such as NHS fundraising events, urgent requests from faculty and school organizations, or community volunteering events in which the NHS will participate, will be posted as they arise.
- School Events: NHS members help with setup and cleanup at several events. They also often distribute programs and take care of supervision and crowd control. There are also several school events which they directly organize and conduct.
- NHS Fundraising Events: The NHS is responsible for its own funding. The NHS expenses include decorations and flowers for the induction ceremony, and honor cords for the graduating NHS seniors. The NHS usually raises funds by doing a few bake sales during the school year, though alternative fundraising opportunities are always a possibility.
- Urgent Requests: It is not uncommon for a principal, teacher, PTF member, or other event organization committee leader to request help from the NHS in supervising young students, doing manual labor, or assisting in some other capacity. When we have time and members available we try to oblige.
- Community Volunteering: NHS members are encouraged to volunteer in the local community. They often do so on an individual basis, but on occasion the group may decide to participate in or even organize such an event together.
- Tutoring: Many NHS members are asked to tutor a younger student at the school on a regular basis. To preserve confidentiality, individual tutoring schedules are NOT posted on this calendar.
Please note: NHS is a volunteer student organization. While NHS members are strongly encouraged to participate in NHS events, none of the events are mandatory. NHS students will not be penalized for failure to attend an NHS event.
Useful Links
- Bylaws
- Officer Roles and Eligibility
- Rules of Membership
- For information about the US Nationwide National Honor Society please go to the official website: www.nhs.us
- Specific information regarding NHS rules and Governance can be found here: NHS Rules and Governance
- For information about NHS scholarship opportunities go here: Scholarship Awards
Contact Information
Carolyn Lloyd / NHS Advisor
OCSI's National Honor Society can be contacted through the current NHS advisor.
Mrs.Lloyd has been teaching at OCSI since 2005 and advising the National Honor Society for the past 5 years.
Latasha Calvin / Secondary Principal
As part of the High School, the NHS also falls under the oversight of the Secondary Principal.


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- Review
- Open Access
Urticaria and angioedema
© Kanani et al; licensee BioMed Central Ltd. 2011
- Published: 10 November 2011
Urticaria (hives) is a common disorder that often presents with angioedema (swelling that occurs beneath the skin). It is generally classified as acute, chronic or physical. Second-generation, non-sedating H1-receptor antihistamines represent the mainstay of therapy for both acute and chronic urticaria. Angioedema can occur in the absence of urticaria, with angiotensin-converting enzyme (ACE) inhibitor-induced angioedema and idiopathic angioedema being the more common causes. Rarer causes are hereditary angioedema (HAE) or acquired angioedema (AAE). Although the angioedema associated with these disorders is often self-limited, laryngeal involvement can lead to fatal asphyxiation in some cases. The management of HAE and AAE involves both prophylactic strategies to prevent attacks of angioedema (i.e., trigger avoidance, attenuated androgens, tranexamic acid, and plasma-derived C1 inhibitor replacement therapy) as well as pharmacological interventions for the treatment of acute attacks (i.e., C1 inhibitor replacement therapy, ecallantide and icatibant). In this article, the authors review the causes, diagnosis and management of urticaria (with or without angioedema) as well as the work-up and management of isolated angioedema, which vary considerably from that of angioedema that occurs in the presence of urticaria.
- Urticaria
- Angioedema
- Tranexamic Acid
- Chronic Urticaria
- Desloratadine
Mast cells are the primary effector cells in urticaria and in many cases of angioedema. These cells are widely distributed in the skin, mucosa, and other areas of the body, and have high-affinity immunoglobulin E (IgE) receptors. Mast cell degranulation leads to the rapid release of various inflammatory mediators, such as histamine, leukotrienes and prostaglandins, which, in turn, cause vasodilation and leakage of plasma in and below the skin. There is also a more delayed (4–8 hour) secretion of inflammatory cytokines (e.g., tumor necrosis factor, interleukin 4 and 5) that potentially leads to further inflammatory responses and longer-lasting lesions [1].
Although acute urticaria can generally be easily managed and is associated with a good prognosis, chronic, severe urticaria is often associated with significant morbidity and a diminished quality of life [6]. Physical urticaria also tends to be more severe and long-lasting, and is often difficult to treat [1, 3].
The first part of this article will focus on the causes, diagnosis and management of the most common types of urticaria (with or without angioedema). As mentioned earlier, angioedema commonly occurs with urticaria, and evaluation and management are similar to those for urticaria. The latter section will review the work-up and management of isolated angioedema, which varies considerably from the diagnosis and treatment of angioedema that occurs in the presence of urticaria.
Classification and etiology
Chronic urticaria
Chronic urticaria is more common in adults, and affects women more frequently than men [1, 4]. In general, chronic urticaria is classified as either chronic autoimmune urticaria or chronic idiopathic urticaria (see Figure 2) [4, 5]. In chronic autoimmune urticaria, circulating immunoglobulin G (IgG) autoantibodies react to the alpha subunit of the high-affinity IgE receptor on dermal mast cells and basophils, leading to chronic stimulation of these cells and the release of histamine and other inflammatory mediators which cause urticaria and angioedema [2, 5]. Chronic autoimmune urticaria is also associated with antithyroid antibodies in approximately 27% of cases, as well as other autoimmune conditions such as vitiligo (a chronic disorder that causes depigmentation of patches of skin) and rheumatoid arthritis [1, 2, 5]. It has also been proposed that Helicobacter pylori (H. pylori), which has an immunogenic cell envelope, may play an indirect role in the etiology of chronic autoimmune urticaria by reducing immune tolerance and inducing autoantibody formation. However, it is important to note that the limited number of studies conducted in this area have yielded conflicting results [7, 8].
Patients with chronic idiopathic urticaria do not have evidence of autoimmunity. In this form of urticaria, there appears to be persistent activation of mast cells, but the mechanism of mast cell triggering is unknown. Although rare, chronic urticaria may also be a manifestation of a systemic illness [1, 3].
Acute urticaria
The most common causes of acute urticaria (with or without angioedema) are medications, foods, viral infections, parasitic infections, insect venom, and contact allergens, particularly latex hypersensitivity. Medications known to commonly cause urticaria ± angioedema include antibiotics (particularly penicillins, and sulfonamides), non-steroidal anti-inflammatory drugs (NSAID), acetylsalicylic acid (ASA), opiates and narcotics. The predominant foods that cause urticaria are milk, eggs, peanuts, tree nuts, fish, and shellfish. In approximately 50% of patients with acute urticaria, the cause is unknown (idiopathic urticaria) [1, 2, 9].
Physical urticaria
As mentioned earlier, physical urticaria is triggered by a physical stimulus. The most common physical urticaria is dermatographism (also known a "skin writing"), in which lesions are created or "written" on the skin by stroking or scratching the skin. Cholinergic urticaria is also common and results from a rise in basal body temperature that occurs following physical exertion or exposure to heat. Other physical stimuli which can trigger urticaria include exposure to cold (cold-induced urticaria), ultraviolet light (solar urticaria), water (aquagenic urticaria) and exercise. The lesions produced by these physical stimuli are typically localized to the stimulated area and often resolve within 2 hours. However, some patients may experience delayed-pressure urticaria which, as the name implies, comes on slowly after pressure has been applied (i.e., 30 minutes to 12 hours) and can last several hours or even days. Examples of sites typically affected include the waistline (after the wearing of tight-fitting pants) and the area of the ankles or calves that makes contact with the elastic band of socks [1–3, 5].
The diagnosis of urticaria, with or without angioedema, is based primarily on a thorough clinical history and physical examination. Based on the history and physical exam, diagnostic tests may also be considered to help confirm a diagnosis of acute, chronic or physical urticaria.
History and physical examination
The history and physical examination should include detailed information regarding: the frequency, timing, duration and pattern of recurrence of lesions; the shape, size, site and distribution of lesions; potential triggers (e.g., food, medications, physical stimuli, infections, insect stings); response to previous therapies used; and a personal or family history of atopy [1, 3].
Conditions to consider in the differential diagnosis of urticaria.
Urticarial vasculitis
• Lesions are usually painful (rather than pruritic), last >48 hours, and leave discoloration on the skin
Systemic mastocytosis
• Rare condition that involves the internal organs (liver, spleen, lymph nodes, bone marrow), in addition to the skin
Atopic dermatitis
• Chronic, highly pruritic inflammatory skin disease
• Clinical manifestations vary with age
Bullous pemphigoid
• Chronic, autoimmune, blistering skin disease
Erythema multiforme
• Acute, self-limited, skin condition
• Considered to be a type IV hypersensitivity reaction to certain infections, medications, and other various triggers
Familial cold autoinflammatory syndrome
• Rare, inherited inflammatory disorder characterized by recurrent episodes of rash, fever/chills, joint pain, and other signs/symptoms of systemic inflammation triggered by exposure to cooling temperatures
• Onset usually occurs during infancy and early childhood and persists throughout the patient's life
Fixed drug eruptions
• Lesions occur from exposure to a particular medication and occur at the same site upon re-exposure to the offending medication
• Lesions usually blister and leave residual pigmentation
Subacute cutaneous lupus erythematosus
• A non-scarring, photosensitive skin condition
• May occur in patients with systemic lupus erythematosus (SLE) and Sjögren syndrome
Pruritic urticarial papules and plaques of pregnancy
• Benign skin condition that usually arises late in the third trimester of a first pregnancy
Muckle-Wells syndrome
• Rare genetic disease that causes hearing loss and recurrent hives
• May lead to amyloidosis
Schnitzler's syndrome with monoclonal IgG kappa gammopathy
• Rare disease characterized by chronic, non-pruritic hives, periodic fever, bone and joint pain, swollen lymph glands and an enlarged spleen and liver
Diagnostic tests
Skin prick tests (SPTs) and serum-specific IgE tests may help confirm a diagnosis of acute urticaria resulting from allergic or IgE-mediated (type I) reactions to common food allergens, latex hypersensitivity, stinging insect hypersensitivity and certain antibiotics These tests are best performed by allergists with experience in interpreting test results in the appropriate clinical context.
Certain diagnostic tests and assessments can be helpful in the diagnosis and differential diagnosis of chronic urticaria, including: a complete blood count (CBC), serum protein electrophoresis (SPE), the autologous serum skin test (ASST), the basophil activation test, thyroid autoantibodies, H. pylori, antinuclear antibodies (ANA), and erythrocyte sedimentation rate (ESR). SPE can be used to identify increases in IgG and, therefore, may help confirm the diagnosis of chronic autoimmune disease. The presence of thyroid autoantibodies is also suggestive of chronic autoimmune urticaria. An elevated ESR or ANA is often indicative of an underlying systemic condition, such chronic infection or vasculitis [2].
The ASST is currently one of the most useful tests for confirming a diagnosis of chronic autoimmune urticaria (sensitivity: 65–81%; specificity: 71–78%) [11]. It involves intradermal injection of the patient's own serum (collected while the patient is symptomatic) into uninvolved skin. A positive wheal and flare reaction is considered indicative of circulating autoantibodies to the high-affinity IgE receptor on mast cells. However, it should be noted that the ASST is not widely available and is often poorly tolerated by younger children due to the discomfort associated with the intradermal injections [3]. Since basophils are also involved in chronic urticaria, the basophil activation test (the quantification of basophil activation by flow cytometry) may be useful for screening for the autoimmune form of the disease. However, further confirmatory studies are needed before this test is widely accepted as a diagnostic tool [2].
Challenge testing, which reproduces exposure to a suspected stimuli in a supervised clinical environment, is often indicated to confirm a diagnosis of physical urticaria. Cold-induced urticaria can usually be confirmed using the ice cube test (i.e., placing an ice cube in a sealed plastic bag over the forearm for 5-10 min). Dermatographism can be confirmed by lightly scratching the skin, and aquagenic urticaria can be identified by immersion of a body part into warm water or through the application of warm compresses. Hot bath testing can help identify cholinergic urticaria, and the application of weight/pressure to the patient's thigh is helpful in the diagnosis of delayed-pressure urticaria [1, 2].
For some patients with acute urticaria, a specific trigger can be identified (e.g., food, medication, latex, insect venom), and avoidance of the offending agent can be an effective management approach. Patients should be provided with clear, written instructions on appropriate avoidance strategies [2, 3].
Antihistamines commonly used and indicated for the treatment of urticaria.
Usual adult dose
Usual pediatric dose
Second-generation H1-receptor antihistamines (first-line therapy)
Cetirizine (Reactine)
10-40 mg daily
5-10 mL (1-2 teaspoons) daily (children's formulation)
Desloratadine (Aerius)
5-20 mg daily
2.5-5 mL (0.5-1.0 teaspoon) daily (children's formulation)
Fexofenadine (Allegra)
120-480 mg daily
Not currently indicated for children under 12 years of age
Loratadine (Claritin)
10-40 mg daily
5-10 mL (1-2 teaspoons) daily (children's formulation)
First-generation H1-receptor antihistamines (best used as adjunctive therapy for patients with nocturnal symptoms)
Hydroxyzine (Atarax)
25-50 mg, three to four times daily
Children < 6 years: 30 to 100 mg daily in divided doses
Diphenhydramine (Benadryl)
25-50 mg, every -6 hours
2.5-20 mL (0.5-4 teaspoons) every 4 to 6 hours (depending on age/weight)
Cyproheptadine (Periactin)
4-20 mg daily
2-4 mg, two to three times daily (depending on age/weight)
Chlorpheniramine (Chor-Tripolon)
4 mg every 4–6 hours
1 mg every 4–6 hours
Clemastine (Tavist-1)
1.34 - 2.68 mg, two to three times daily
1.34 mg, once or twice daily
Antihistamine efficacy is often patient specific and, therefore, more than one antihistamine should be tried before assuming therapeutic failure with these agents. Also, antihistamines are most effective if taken daily, rather than on an as-needed basis. If symptoms are controlled with standard antihistamine doses, it is reasonable to continue treatment for several months, occasionally stopping therapy for brief periods to determine whether the urticaria has spontaneously resolved. In patients who do not achieve adequate symptom control at standard doses, it is common practice to increase the antihistamine dose beyond the usual recommended dose. In fact, current European guidelines recommend up to four times the usual recommended dose of antihistamine in patients who symptoms persist with standard therapy [12]. For example, doses of up to 40 mg of cetirizine, 20 mg of desloratadine, and 480 mg of fexofenadine may be used in adults. The efficacy of this approach, however, still requires confirmation in randomized, double-blind controlled trials [2, 3].
For some patients with severe urticaria who are inadequately responsive to antihistamines, a brief course of oral corticosteroids (e.g., prednisone, up to 40 mg/day for 7 days) is warranted. However, long-term corticosteroid therapy should be avoided given the well-known side effects associated with prolonged use of corticosteroids and the increased likelihood of developing tolerance to these agents [2, 3].
Immunosuppressive and Immunomodulatory Therapies
Various immunosuppressive or immunomodulatory therapies may provide some benefit for patients with severe, chronic urticaria. Double-blind, randomized controlled trials have found cyclosporine (3–5 mg/kg/day) to be effective in patients with chronic urticaria who do not adequately respond to antihistamines [13, 14]. During treatment with cyclosporine, H1-receptor antihistamines should be continued, and blood pressure, renal function and serum levels should be monitored regularly given the significant side effects associated with this form of therapy (e.g., hypertension, renal toxicity).
Case reports and other small clinical trials have also found the following treatments to be effective for select patients with severe, refractory, chronic urticaria: sulfasalazine; the antibacterial, dapsone; the anti-IgE monoclonal antibody, omalizumab; and intravenous immunoglobulin G (IVIG) [4]. However, the efficacy of these agents in the treatment of chronic urticaria needs to be confirmed in large, randomized controlled trials.
Other therapies
Leukotriene receptor antagonists, such as montelukast (Singulair) or zafirlukast (Accolate), have also been shown to be effective in the treatment of poorly-controlled chronic urticaria [15–17]. However, these agents should only be used as adjuncts to antihistamine therapy as there is little evidence that they are useful as monotherapy. Injectable epinephrine should also be prescribed to patients with a history of severe urticaria and angioedema leading to anaphylaxis (see article on anaphylaxis in this supplement) [1].
Angioedema (without Urticaria)
Angioedema in the absence of urticaria is rare and should alert the physician to alternative diagnoses, such as hereditary or acquired angioedema, idiopathic angioedema, or angioedema associated with angiotensin-converting enzyme (ACE) inhibitors. Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder resulting from an inherited deficiency or dysfunction of the C1 inhibitor (a plasma protease inhibitor that regulates several proinflammatory pathways). Two main types of HAE have been defined: type I and type II. Type I HAE is characterized by low C1 inhibitor levels and function (85% of cases) while type II is associated with normal C1 inhibitor levels, but low function (15% of cases). Acquired angioedema (AAE) is another rare C1 inhibitor deficiency syndrome which is most commonly associated with B-cell lymphoproliferative diseases (type 1 AAE). It may also be related to the presence of an autoantibody directed against the C1 inhibitor molecule (type II AAE) [18].
Comparison of HAE and AAE.
Age of onset
Family history
Complement levels
C1 inh level
C1 inh function
Type 1
Type 2
Normal or low
Although the exact pathogenesis of attacks of HAE and AAE remains unclear, excess production of the potent vasodilatory peptide, bradykinin (which is regulated by the C1 inhibitor), appears to play an important role [20]. It is important to note that histamine and other mast cell mediators that are typical of urticaria and associated angioedema are not directly involved in HAE and AAE, which explains patient lack of response to antihistamines and corticosteroids, and distinguishes these forms of isolated angioedema from that associated with urticaria.
Isolated angioedema also occurs in approximately 0.1% to 6% of individuals using ACE inhibitors. It tends to occur more commonly in ACE-inhibitor users who are female, smokers or of African-American descent. Like HAE and AAE, ACE inhibitor–induced angioedema is bradykinin-mediated. Most cases of angioedema occur in the first week after starting ACE-inhibitor therapy. However, up to one-third of cases occur months to years after initiating the medication [21]. ACE inhibitor-induced angioedema can be life-threatening when it involves the upper airway and, therefore, ACE inhibitors should be discontinued in all individuals with angioedema.
In the majority of cases of isolated angioedema, the cause is not identifiable (idiopathic angioedema). The exact mechanisms of idiopathic angioedema are unclear; however, based on patient response to medication, some cases are believed to be mediated by IgE-independent mechanisms that lead to mast cell activation [22, 23]. In most individuals, this condition does not lead to life-threatening angioedema.
The diagnosis of HAE and AAE is based upon a suggestive clinical history (i.e., episodic angioedema in the absence of urticaria affecting the skin, gastrointestinal and upper respiratory tracts) and the presence of abnormalities in specific complement proteins. Complement studies that should be ordered for patients with suspected HAE and AAE include: C4 (the natural substrate for C1) level, C1q level, C1 inhibitor antigenic level, and C1 inhibitor functional level [18]. These studies should be performed when the patient is not receiving treatment, since the use of therapeutic interventions for AAE or HAE can alter laboratory results.
In most patients with AAE, C4, C1q, and C1 inhibitor function levels are low (<50% of normal), and C1 inhibitor antigenic levels are low or normal. In type I HAE, C1 inhibitor antigenic and function levels are low (<50% of normal); in type II HAE, C1 inhibitor functional levels are low, but antigenic levels are normal or elevated (see Table 3). Unlike AAE, C1q levels are normal in HAE. ACE-inhibitor-induced angioedema should be considered if complement studies are normal and the patients is currently using ACE inhibitor therapy. Patients with AAE should also be evaluated for an underlying B-cell lymphoproliferative disorder at the time of diagnosis [18].
The treatment of idiopathic angioedema is similar to that of urticaria. The condition responds well to prophylactic antihistamines. In some individuals, corticosteroids are required. Alcohol and NSAIDs can exacerbate this condition and, therefore, avoidance is advised.
Overview of therapeutic interventions for HAE and AAE.
Acute attacks
• Trigger avoidance
– Mild trauma
– Anxiety/stress
– H. pylori infection
– ACE inhibitors
– Estrogen-containing medications
• Attenuated androgens
– Danazol
– Stanozolol
• Tranexamic acid
• C1 inhibitor replacement therapy
• C1 inhibitor replacement therapy
• Ecallantide (kallikrein inhibitor)
• Icatibant (bradykinin receptor blocker)
Prophylactic treatment
Prophylactic therapy should be considered in patients who experience more than one severe attack per month, or if treatment for acute episodes is not sufficiently effective or is not available. Therapeutic options include: trigger avoidance, attenuated androgens, tranexamic acid, and plasma-derived C1 inhibitor replacement therapy [18, 24].
Factors triggering acute attacks of AAE and HAE vary but often include: mild trauma to the face (particularly dental trauma), stress/anxiety, H. pylori infection, menstruation, and the use of estrogen-containing medications (e.g., hormone replacement therapy and contraceptives) and ACE inhibitors. Whenever possible, these triggers should be avoided. Recognition and prompt treatment of oral and dental infections, and screening for and eradication of H. pylori infection may be warranted in some cases [18].
Attenuated androgens, such as danazol and stanozolol, increase C4 and C1 inhibitor levels and are effective for both the short- and long-term prophylaxis of HAE and AAE. Although generally well-tolerated by most patients, adverse effects with long-term androgen administration may include virilization, abnormalities in serum transaminases, menstrual irregularities, hair growth, decreased libido, weight gain, vasomotor symptoms, lipid abnormalities, and depression. Therefore, the lowest effective dose should be utilized (maximum long-term recommended doses are 200 mg daily for danazol and 2 mg daily for stanozolol), and the patient's CBC, liver enzymes and lipid profile should be monitored regularly (e.g., every 6 months) while on therapy. Contraindications to androgen therapy include: pregnancy, lactation, cancer, hepatitis, and childhood [18].
The antifibrinolytic agent, tranexamic acid, has also been shown to be effective for the prophylactic treatment of HAE and AAE. Evidence suggests that it may be less effective than androgen therapy in patients with HAE, but more effective in AAE [18]. Tranexamic acid is well-tolerated and is generally preferred for long-term prophylaxis in pregnant women, children, and patients who do not tolerate androgens. The most common side effect is dyspepsia, which can be reduced by taking the drug with food [18].
Regular intravenous injections of plasma-derived C1 inhibitor replacement therapy are also effective for both short- and long-term prophylaxis. These injections can usually be administered at home by the patient or caregiver. The current recommended dose is 20 units/kg; patients with AAE may require higher doses. Since C1 inhibitor replacement therapy is a blood product, annual recipient hemovigilance and vein-to-vein tracking are essential [18].
Treatment of acute attacks
First-line therapies for the treatment of severe acute attacks of HAE and AAE include: C1 inhibitor replacement therapy, ecallantide and icatibant [18]. C1 inhibitor replacement therapy is the most well-studied first-line therapy; it is administered "on-demand" at the first sign of an attack. However, some patients with AAE may become non-responsive to this treatment over time; in these patients the use of ecallantide and icatibant should be considered [24].
Ecallantide is an inhibitor of plasma kallikrein (the enzyme that releases bradykinin, the primary mediator of angioedema). It has recently been approved by the Food and Drug Administration (FDA) in the United States for the treatment of acute angioedema attacks in patients with HAE. The usual recommended dose is 30 mg subcutaneously (adults). Although the side effects of ecallantide are generally mild (i.e., injection-site reactions, headache, nausea, fatigue, diarrhea), this therapy has been associated with rare instances of allergic reactions and anaphylaxis. Therefore, it should only be administered by a clinician in a medical setting equipped to manage anaphylaxis and severe angioedema [18].
Icatibant is a bradykinin receptor blocker that has been approved in the European Union for the treatment of acute attacks of HAE. The usual recommended dose for adults is 30 mg subcutaneously; pediatric experience with this agent is still pending. The most common side effects of icatibant are mild and transient injection site reactions. Other, less common side effects include: nausea, gastrointestinal upset, asthenia, dizziness, and headache [18].
Urticaria is a common disorder that often presents with angioedema. It is generally classified as acute (lesions occurring for < 6 weeks), chronic (lesions occurring for > 6 weeks) and physical (lesions result from a physical stimulus). The disorder can usually be diagnosed on the basis of clinical presentation and history, however, diagnostic tests may be helpful for confirming the diagnosis. Second-generation, non-sedating H1-receptor antihistamines represent the mainstay of therapy for both acute and chronic urticaria; first-generation sedating antihistamines may be used as adjunctive therapy in patients with nocturnal symptoms. For severe, refractory chronic urticaria, short courses of oral corticosteroids and certain immunosuppressant and immunomodulatory therapies may be beneficial.
Angioedema can occur in the absence of urticaria. The more common causes are ACE inhibitor-induced angioedema and idiopathic angioedema. Rare, but life-threatening causes are HAE or AAE. The work-up and management of HAE and AAE varies considerably from that of angioedema associated with urticaria. Although the angioedema associated with these disorders is often self-limited, laryngeal involvement can lead to fatal asphyxiation. Patients with these disorders demonstrate characteristic abnormalities in certain complement levels and, therefore, diagnostic testing of patients with suspected HAE or AAE should include assessment of C4, C1q and CI inhibitor function and antigenic levels. HAE should be considered in patients with an early age of onset and a family history of the disorder; in patients with AAE, there is no family history and age of onset is usually later. Therapeutic options for the prophylaxis of HAE and AAE include: trigger avoidance, attenuated androgens, tranexamic acid, and plasma-derived C1 inhibitor replacement therapy. First-line therapies for the treatment of acute attacks include: C1 inhibitor replacement therapy, ecallantide and icatibant.
Key take-home messages
Urticaria is a common disorder characterized by recurrent, pruritic (itchy) lesions with pale centers (wheals) that usually subside within 48 hours; it is often associated with angioedema.
Mast cells are the primary effector cells in urticaria.
Urticaria is classified as acute (lesions for < 6 weeks), chronic (lesions > 6 weeks), or physical.
The diagnosis of urticaria, with or without angioedema, is based primarily on a thorough clinical history; however, diagnostic tests may be helpful in some instances.
Second-generation, non-sedating H1-receptor antihistamines are the mainstay of therapy for urticaria. Oral corticosteroids and various immunomodulatory/immunosuppressive therapies may also be used for more severe, chronic cases.
Angioedema can occur in the absence of urticaria, with ACE inhibitor-induced and idiopathic angioedema being the most common causes.
ACE inhibitors should be discontinued in any individual who presents with angioedema as this condition is associated with life-threatening upper airway angioedema.
Idiopathic angioedema responds well to prophylactic antihistamines, however, oral corticosteroids may be required in some cases.
HAE and AAE are rare disorders also characterized by angioedema in the absence of urticaria; they result from a deficiency or dysfunction of the C1 inhibitor (a plasma protease inhibitor that regulates several proinflammatory pathways), and are associated with life threatening upper airway swelling.
Diagnosis of HAE and AAE should include the assessment of C4, C1q, C1 inhibitor function and antigenic levels.
The management of these disorders involves both prophylactic strategies to prevent attacks of angioedema (trigger avoidance, attenuated androgens, tranexamic acid, and plasma-derived C1 inhibitor replacement therapy) as well as pharmacological interventions for the treatment of acute attacks (C1 inhibitor replacement therapy, ecallantide and icatibant).
This article has been published as part of Allergy, Asthma & Clinical Immunology Volume 7 Supplement 1, 2011: Practical guide for allergy and immunology in Canada. The full contents of the supplement are available online at http://www.aacijournal.com/supplements/7/S1
Authors' Affiliations
- Amar SM, Dreskin SC: Urticaria. Prim Care. 2008, 35: 141-157. 10.1016/j.pop.2007.09.009.View ArticlePubMedGoogle Scholar
- Poonawalla T, Kelly B: Urticaria: a review. Am J Clin Dermatol. 2009, 10: 9-21. 10.2165/0128071-200910010-00002.View ArticlePubMedGoogle Scholar
- Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM, British Society for Allergy and Clinical Immunology (BSACI): BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007, 37: 631-650. 10.1111/j.1365-2222.2007.02678.x.View ArticlePubMedGoogle Scholar
- Fonacier LS, Dreskin SC, Leung DY: Allergic skin diseases. J Allergy Clin Immunol. 2010, 125 (2 Suppl 2): S138-149.View ArticlePubMedGoogle Scholar
- Kaplan AP: Chronic urticaria: pathogenesis and treatment. J Allergy Clin Immunol. 2004, 114: 465-474. 10.1016/j.jaci.2004.02.049.View ArticlePubMedGoogle Scholar
- Weldon DR: Quality of life in patients with urticaria. Allergy Asthma Proc. 2006, 27: 96-99.View ArticlePubMedGoogle Scholar
- Hizal M, Tuzan B, Wolf R, Tüzün Y: The relationship between Helicobacter pylori IgG antibody and autologous serum test in chronic urticaria. Int J Dermatol. 2000, 39: 443-445. 10.1046/j.1365-4362.2000.00979.x.View ArticlePubMedGoogle Scholar
- Hook-Nikanne J, Varjonen E, Harvima RJ, Kosunen TU: Is Helicobacter pylori infection associated with chronic urticaria?. Acta Derm Venereol. 2000, 80: 425-426. 10.1080/000155500300012837.View ArticlePubMedGoogle Scholar
- Winters M: Initial evaluation and management of patients presenting with acute urticaria or angioedema. 2006, American Academy of Emergency Medicine (AAEM), Position Statement. Available at: http://www.aaem.org/positionstatements/clinical_practice_guidelines.php Accessed December 14, 2010Google Scholar
- Davis MD, Brewer JD: Urticarial vasculitis and hypocomplementemic urticarial vasculitis syndrome. Immunol Allergy Clin North Am. 2004, 24: 183-213. 10.1016/j.iac.2004.01.007.View ArticlePubMedGoogle Scholar
- Greaves MW: Chronic idiopathic urticaria. Curr Opin Allergy Clin Immunol. 2003, 3: 363-368. 10.1097/00130832-200310000-00008.View ArticlePubMedGoogle Scholar
- Zuberbier T, Asero R, Bindslev-Jensen C, Walter Canonica G, Church MK, Giménez-Arnau AM, Grattan CE, Kapp A, Maurer M, Merk HF, Rogala B, Saini S, Sánchez-Borges M, Schmid-Grendelmeier P, Schünemann H, Staubach P, Vena GA, Wedi B, Dermatology Section of the European Academy of Allergology and Clinical Immunology, Global Allergy and Asthma European Network, European Dermatology Forum, World Allergy Organization: EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria. Allergy. 2009, 64: 1427-43. 10.1111/j.1398-9995.2009.02178.x.View ArticlePubMedGoogle Scholar
- Grattan CE, O'Donnell BF, Francis DM, Niimi N, Barlow RJ, Seed PT, Kobza Black A, Greaves MW: Randomized double-blind study of cyclosporine in chronic 'idiopathic' urticaria. Br J Dermatol. 2000, 143: 365-372. 10.1046/j.1365-2133.2000.03664.x.View ArticlePubMedGoogle Scholar
- Vena GA, Cassano N, Colombo D, Peruzzi E, Pigatto P, Neo-I-30 Study Group: Cyclosporine in chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled trial. J Am Acad Dermatol. 2006, 55: 705-709. 10.1016/j.jaad.2006.04.078.View ArticlePubMedGoogle Scholar
- Asero R, Tedeschi A, Lorini M: Leukotriene receptor antagonists in chronic urticaria. Allergy. 2001, 56: 456-457. 10.1034/j.1398-9995.2001.056005456.x.View ArticlePubMedGoogle Scholar
- Ellis MH: Successful treatment of chronic urticaria with leukotriene antagonists. J Allergy Clin Immunol. 1998, 102: 876-877. 10.1016/S0091-6749(98)70032-6.View ArticlePubMedGoogle Scholar
- Erbagci Z: The leukotriene receptor antagonist montelukast in the treatment of chronic idiopathic urticaria: a single-blind, placebo-controlled, crossover clinical study. J Allergy Clin Immunol. 2002, 110: 484-488. 10.1067/mai.2002.126676.View ArticlePubMedGoogle Scholar
- Bowen T, Cicardi M, Farkas H, Bork K, Longhurst HJ, Zuraw B, Aygoeren-Pürsün E, Craig T, Binkley K, Hebert J, Ritchie B, Bouillet L, Betschel S, Cogar D, Dean J, Devaraj R, Hamed A, Kamra P, Keith PK, Lacuesta G, Leith E, Lyons H, Mace S, Mako B, Neurath D, Poon MC, Rivard GE, Schellenberg R, Rowan D, Rowe A, Stark D, Sur S, Tsai E, Warrington R, Waserman S, Ameratunga R, Bernstein J, Björkander J, Brosz K, Brosz J, Bygum A, Caballero T, Frank M, Fust G, Harmat G, Kanani A, Kreuz W, Levi M, Li H, Martinez-Saguer I, Moldovan D, Nagy I, Nielsen EW, Nordenfelt P, Reshef A, Rusicke E, Smith-Foltz S, Späth P, Varga L, Xiang ZY: 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema. Allergy Asthma Clin Immunol. 2010, 6: 24-10.1186/1710-1492-6-24.PubMed CentralView ArticlePubMedGoogle Scholar
- Zingale LC, Castelli R, Zanichelli A, Cicardi M: Acquired deficiency of the inhibitor of the first complement component: presentation, diagnosis, course, and conventional management. Immunol Allergy Clin North Am. 2006, 26: 669-690. 10.1016/j.iac.2006.08.002.View ArticlePubMedGoogle Scholar
- Cugno M, Zanichelli A, Foieni F, Caccia S, Cicardi M: C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress. Trends Mol Med. 2009, 15: 69-78. 10.1016/j.molmed.2008.12.001.View ArticlePubMedGoogle Scholar
- Byrd JB, Adam A, Brown NJ: Angiotensin-converting enzyme inhibitor-associated angioedema. Immunol Allergy Clin North Am. 2006, 26: 725-37. 10.1016/j.iac.2006.08.001.View ArticlePubMedGoogle Scholar
- Banerji A, Sheffer AL: The spectrum of chronic angioedema. Allergy Asthma Proc. 2009, 30: 11-6. 10.2500/aap.2009.30.3188.View ArticlePubMedGoogle Scholar
- Frigas E, Park M: Idiopathic recurrent angioedema. Immunol Allergy Clin North Am. 2006, 26: 739-51. 10.1016/j.iac.2006.09.004.View ArticlePubMedGoogle Scholar
- Frank MM, Jiang H: New therapies for hereditary angioedema: disease outlook changes dramatically. J Allergy Clin Immunol. 2008, 121: 272-280. 10.1016/j.jaci.2007.11.019.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Personally, I didn't know that there is a brand new "Tablet" device released by Motorola after the Motorola Xoom. That why, I didn't write the Motorola Droid XYBoard and didn't share the User Guide or the Quick Start Guide of this tablet at this blog, until the this day. Even though, it is a little bit late, late get a closer understanding about this Droid XYBoard.
Droid XYBoard divided into two specific detail. There are Motorola Droid XYBoard 10.1 and Motorola Droid XYBoard 8.2. The 10.1 and 8.2 number indicated the Display diagonal size used by the tablet. At here, we would discuss the XYBoard for 10.1. We'll gave you the 8.2 later.
Nowadays, the tablet gadget seems to be one of the trend in market which is almost replaced the popularity of Netbook. Yup, in my opinion, sooner or later, the netbook which was had gain it peak popularity on 2008 would be replaced by the Tablet. Then, the tablet era will come. That why many vendor or manufacturer are in pace to released their own tablet, such as the Motorola which released the latest Motorola Droid XYBoard 10.1.
The 10.1 display that uses IPS-enhanced TFT Capacitive touchscreen (some other source mentioned that the XYBoard 10.1 uses HD-IPD LCD capacitive touchscreen, although, I tought this only a guess mode, but the official tech specs of this tablet, said it uses IPS-Enhanced) has 1280 x 800 pixels resolution and and embedded in body of anodized aluminum at size of 253.9 mm x 173.6 mm x 8.80 mm dimension and about 603 grams weight. Btw, Droid Xboard 10.1 also has series code name as MZ617, in which we can said as Motorola Droid XYBoard 101 MZ617.
Motorola DROID XYBoard 10.1 Manual User Guide Quick Start Guide Tablet Resume
Even though the size of the User Manual / User Guide of Motorola DROID XYBoard is huge, which is about 14MB, on the contrary, the elaboration on guiding the tutorial explanation available inside the User Guide are quite simple. It seems that the huge file of UM occurred because of the images tutorial embedded in the UG are really good in detail and colorful.
The image that we shared above, actually we arranged from page 2 under "Welcome" section and also page 3 under "Your Tablet" sections. It is a short and quick tutorial figure that would give you an screen shot of your Droid XYBoard 10.1 with its keys locations, and parts name overview. You can learn which one is the headphone jack, which is the microSIM slot, where the volume keys, the microUSB port charge, the power or lock keys, the widgets, the search, and shortcuts.
Let jump to page 50 of the User Guide of XYBoard 10.1. The contents that appear in this page are the tutorial and explanation how you can use the bluetooth and also use the Wi-Fi or Wi-Fi hotspot router connections. Back to page 43, you can learn how to use the Google eBooks, including how to get the books, how to read it and more.
To do a Reboot or Restart or soft reset on this tablet, just Press and hold the power / lock button and volume up keys for about 12 seconds. Then the XYBoard would reboot automatically. This reboot case usually should be done if you face that the device becomes unresponsive or hang or stop responding or the touchscreen freeze.
If the problem seems still appears occasionally, and you don't bother if you data removed or deleted (you should back up first) you can perform a factory reset or hard /master reset: Home > Apps > Settings > Privacy > Factory Data reset > Done. This is how you can do Master Reset.
About the Getting Started Guide aka Quick Start Guide of Motorola Droid XYBoard 10.1, it was a quick tutorial on how to use the tablet, for example to use the touch, homescreen, assemble an chager, key tips, manage contents, using android market, using MotoCast to stream content, floating notes and etc. For short, it likes a "resume" of User Guide version of XYBoard 10.1.
If you see a blank page, just Reload your browser.
Motorola DROID XYBoard 10.1 Tablet Technical Specifications
Powered with Android version 3.2 aka Honeycomb Operating System by Google, the Motorola Droid XYBoard 10.1 also installed with Dual core 1.2GHz Cortext A9 with PowerVR SGX540 GPU and TI OMAP 4430 for the chipset along with 1GB RAM.
The Droid XYBoard 10.1 also divided into three optional choices in term of internal storage capacity. This would decided the price comes along with this tablet. There are 16GB, 32GB and 64GB. This optional storage should be chosen carefully because of there is no card slot for external expandable memory (microSD). If you tend to use huge data or applications you should pick the largest one. But in case you just wanna surf the internet or not many data that you would store, just choose the 16GB or 32GB. That would save "quite plenty" of dollar :).
Motorola Droid XYBoard is a kind of Global Tablet. It support for GSM Networks and CDMA networks technology. It even support 4G LTE and EVDO Rev.B. HSDPA 42 Mbps, HSUPA 5.76Mbps (upto), the EDGE, GPRS and GSM also available. Remember, almost all the tablet nowadays, not able to be used as Voice communications data networks like SMS, MMS, or Mobile Phone calling / receiving, but you can still use it as Video Chat via Skype, Google Talk, Qik, or do instant messaging activity likes YM, Windows Live Messenger, ICQ and more (need to download the apps from Android Market).
Bluetooth version 2.1 plus IDR, microUSB, HDMI out, Wi-Fi 802.11 a/b/g/n, also available.
For the Camera, there are dual camera installed in the XYBoard 10.1. One has 5 Megapixel Resolution attached on the rear side panel of the tablet, and the second one is front facing 1.3 MP Camera. The 5MP Cam has a LED Flash, support autofocus, geo tagging and can record up to HD 720p@30fps video. For the battery, it uses Li Ion battery with 7000 mAh capacity. It approximately can be use up to 10 hours with Wi-Fi connection .
Table of Contents of Motorola DROID XYBoard 10.1 Manual User Guide Tablet
Your Tablet
Insert LTE micro SIM
Navigation tips
Touch entry
Home screen
Input Options
Email and Contacts
Google eBooks
Want more?,
Touch and Navigation
Home screen
Apps and Updates;
Android Market
Recent apps
Manage and Restore apps
Update my tablet
Important customer information,
Touch typing;
Entry Options
Typing tips,
Photos and Video
Tips and Tricks
Bluetooth wireless
Wi-Fi Hotspot,
Safety, regulatory and Legal
Motorola DROID XYBoard 10.1 Manual User Guide Tablet Quick Start Guide PDF Download
The tutorial how to open cover the micro SIM (4G LTE or GSM Carrier SIM card), how to insert and install the SIM card, close the microSIM cover and charge up like it been shown on the picture below, can be found both in User Guide (page 4) and also at Getting Started Guide (page 6).
And here are the GSG and UG of the Motorola Droid XYBoard 10.1. Especially for the User Guide PDF File, please download the file using your best internet connections, if you had poor connections using Download Manager is very recommended.
- Download User Guide of Motorola DROID XYBoard 10.1 | Language: English | PDF Size: 14.0MB | Page: 71
- Download Getting Started / Quick Start Guide of Motorola DROID XYBoard 10.1 | Language: English | PDF Size: 1.32MB | Page: 26


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Company Profile
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Australia Offices: Wagga Wagga, NSW; Brisbane, QLD; Bunbury, WA; East Geelong, VIC; Gunnedah, NSW; Narrabri, NSW; Perth, WA
European Offices: Cambridge, UK; Gdansk, Poland; Warsaw, Poland
Brazil Offices: Sao Paulo, Brazil; Piracicaba, Brazil


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How do you get in this door? Or is it an "out only" door...in which case, where do the people inside actually come from? I'm just saying...
It's been a wee while since I blogged. And not really because nothing's been happening. I don't know why really. Maybe because I didn't have any good photos.
I thought I'd take the bus to work today and then run home. It's about 6 miles if I go the most direct way, but there are plenty of ways to expand it. I took my camera and acted like a tourist on the bus. I still find it quite exciting taking a bus along Princes Street and looking at everything. I'm from Orkney, remember, where, when I was there, there was one roundabout, one set of traffic lights and no double-decker buses at all. I don't think I'd have been able to contain myself when I first came to Edinburgh if there had been trams too. It's just as well they held off....
Last week I was going to write a blog called "Electrolytes and the Diarrhea Kid", partially just to get attention and partly because I had a surprise bout of "delicate digestion" which made me rapidly reassess my marathon training strategy.
I say strategy, but for some reason I have dived (diven?) head-long into doing lots of long runs and my legs have been getting increasingly sore and heavy and my pace has been getting worse and worse. I had a peep at what I was doing last year this time before the E2NB race and saw to my horror that I wasn't doing nearly as much volume but all my medium length runs (12ish miles) were way faster than this year. I decided to cut back on my mileage and take it easy. I have E2NB again in a couple of weeks time so it seems reasonable to do a taper for that and then a couple more weeks highish mileage after it and then taper again for the Edinburgh Marathon.
It has taken over a week for my tummy to start to feel resilient again.
I have a Gestalt Therapy weekend ahead. Don't ask. So I won't be able to get much running in. I reckon I'll get up early on Sunday morning and run 10 or so if I can face it. That's why I took the bus today...to run home and get some miles in...
I started out taking photos on the bus, but then I got interested in the people. I was sitting right at the front and on the other side there was a pale blonde girl, listening to music. Around Haymarket she got her makeup out and started to plaster her face with powder. She really mashed it on. More like she was white-washing harling than dusting a face. It went on and on. She clearly wanted to make sure not one millimetre of skin would be on show. Then she painted on pink cheeks. I was finding it hard not to watch too keenly. It was a relief when she got off. Apparently face skin's a no-no at the moment. You heard it first here. Then a slightly chubby wee boy got on. Maybe 8 years old. He looked kind of normal. Near to my stop he saw a friend at the bus-stop waiting to get on and started to wave vigorously...very vigorously...his friend came up the stairs.
"Yo man, wazz-up?" inquired the friend.
"Birth...babyness...screaming..." intoned my seat mate and I began to wonder if he was not well.
His friend raised his eyebrows. "Fraser is teething" was the explanation. They both nodded silently.
I feel there's a lot of things I've been missing out on. I might get the bus again next week just for the experience.
I had a nice run home. 10.5 miles. It was over-cast but hot and humid.
There are things afoot at work so maybe I'll be getting funded to do another course but have to work an extra day too. It's good in a way. But I love my freedom. And I've just discovered a fun way to end the week.....Life...it's all swings and roundabouts....