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ICEGOV 2017 - New Delhi, India
Events | 18.1MB
Events | 18.1MB
Knowledge Societies empower citizens to use the facilities available through digital infrastructures to have the freedom to live their lives in the manner they want to live. Governments, civil society and private enterprises often see their role as enablers of the knowledge society by providing needed services, support and products.
Governments have overwhelmingly adopted digital means to ignite and sustain this empowerment. Responding to social, economic, political and other pressures, they use digital technology to innovate their policies, processes, structures and interactions with partners and citizens alike, and institutionalize such innovations over time. Four waves of Digital Government innovations emerged: 1) Digitization – improving internal government operations and delivering better public services, 2) Transformation – facilitating administrative and institutional reform in government, 3) Engagement – engaging citizens and non-state actors in policy- and decision-making processes and 4) Contextualization – supporting policy and development goals in specific sectors and localities. Focused on creating conditions for self-governance and self-development on the local, sectorial and national levels, the Contextualization stage is directly relevant to Knowledge Societies.
The challenges facing researchers and practitioners today have to do with ensuring that the digitalization in society leads to transformation and empowerment, and finally to positive, sustained development outcomes. Policy makers and decision makers in government have to understand and deal with a whole host of issues related to building Knowledge Societies, and this call-for-papers highlights many of these issues. The main purpose of ICEGOV2017 is to explore how Digital Government can lead to Digital Empowerment, relying on locally-appropriated Knowledge Societies as both the means and the end to such empowerment.
The ICEGOV series brings together academia, governments, international organizations, civil society, and the private sector to share the insights and experiences in theory and practice of Digital Government. ICEGOV promotes interactions between stakeholders – policymakers, government officials, elected representatives, researchers, innovators and educators from developing and developed countries – all sharing a concern that public investment in Digital Government advances public policy and development. ICEGOV is a platform where such stakeholders can discuss ways of working together across the national, sectorial, development and other boarders towards addressing this concern.
Following the earlier conferences in Macau (ICEGOV2007), Cairo (ICEGOV2008), Bogotá (ICEGOV2009), Beijing (ICEGOV2010), Tallinn (ICEGOV2011), Albany (ICEGOV2012), Seoul (ICEGOV2013), Guimarães (ICEGOV2014) and Montevideo (ICEGOV2016), the ICEGOV series has become a source of significant research and policy insight, able to reach national and global policy and research audiences. In figures, the ICEGOV community includes 1548 authors and reviewer from 102 countries – 69% from academia, 18% from government, 9% from industry and 4% from international and other organization. Also, on average, every ICEGOV conference attracts 140 submissions from 49 countries and is attended by over 400 participants from 50 countries including government (40%), academia (36%), industry and civil society (14%), and international organizations (10%).
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Nov 06, 2009[IMG Disclaimer This work is fiction and should be treated as such. The author of this story does not own the rights to either Star Trek or

subset: commoncrawl


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How many times have we said to ourselves "if I only knew..."?
I've been monitoring this train wreck - sorry - country, very carefully for several months. Seen the cogs on the wheel slip one after the other while I nervously wonder how many cogs are left on the wheel. All the while, people are in denial. Sure there's a whole lot of talk and complaining and whining but is anything really being done? Can anything really be done?
I fear the day when the last cog will slip and all will be plunged into darkness.
Friday Night Jam: Beck Goes Fluffy: "Fix Me"
14 hours ago


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Science Another great weather unit idea - paper plate weather charts.
Make these simple sensory bottles as a hands-on manipulative to talk about the weather. Great for circle time! I would use this in a kindergarten class. put the children in 5 groups and let them tell class mates what they think about their bottle.
Weather Activities for Kids.fun science experiments to help kids learn about the weather by alyce
Play this fun game to help your Cub Scouts learn what to do in severe weather situations that might occur while you're camping.


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What To Do If Your Child Is Injured
Your child getting an injury is something that every parent does not want to happen. Even so, there are just bad things waiting to happen, and if this involves your child, then you better be prepared beforehand. Injuries have a wide range of causes and can happen at any place possible. Your child may be injured at the park, at school, or even just at your home. If you are more than prepared with the worst that can happen to your child, then you are all the more prepared to get through this situation. Furthermore, you become less stressed which also helps in keeping your child calm and ensuring that he or she will be able to recover more quickly. Below are some useful tips that you can keep in mind when your child gets an injury.
Tip #1: Know more about first aid
If you are a parent, it is best that you know a lot about basic first aid in case you get in a situation where there are injuries or accidents happening. If you are both knowledgeable and skilled in looking after an injury when you are still waiting for emergency personnel to arrive, then you are more in control of the current situation that you are in. When you have control over the situation, then there is no more cause for panic because you can be calm unlike those who do not know a thing about first aid. There are a number of places where you can find in your area that offer basic first aid classes where you can also get a certificate after. If you do not have the extra time, then you can always check out first aid guides and tutorials being made available online for free.
Tip #2: Taking hospital visits
Common injuries during childhood such as cuts, bruises, and scrapes can be easily taken care of with the help of a band-aid, some antiseptic solution, and parental love. Yet, you are required to take your child to the hospital if he or she sustains an injury that is serious. Take, for example, if your child gets s a broken bone, then before you can put some cast on it, it is vital to have it examined by a doctor and have it checked on an x-ray. It cannot be denied that your child will feel not only frightened but also stressed out when they are faced with such a situation. Remaining calm as possible is the best thing that you can do as a parent because if your child will see how stressed out you are, then they also become worried.
Tip #3: Make a claim
Consider making a claim if the cause of your child's injury was another person and not your own child. Ensure to seek the services of a reliable personal injury lawyer if you want to get the claim that you and your child deserve.


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My first facebook profile pic wasn't worth posting; but my #firstigselfie turned out to be one of my favourites. Me with my parents & daughter at the Olympics. I don't really do selfies, but sometimes am pleased to discover my old self in the frame.
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Wood Profits - Small space idea for the living room! A skinny table with a built-in outlet for behind the couch.
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496 vind-ik-leuks, 12 reacties - April and May
Boho and nordic living room. Wohnzimmer im skandinavischen Stil


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The device, called a left ventricular assist device (LVAD), is the latest generation of heart assist devices. The LVAD was tested at five main sites: Washington University School of Medicine in St. Louis, the University of Minnesota, Mt. Sinai School of Medicine, Inova Fairfax Hospital and the University of Pittsburgh.
"LVADs have allowed us to support patients until they can receive a heart transplant, so they are called a bridge to transplant," says Gregory Ewald, M.D., a Washington University cardiologist at Barnes-Jewish Hospital and medical director of the Heart Failure, Cardiac Transplantation and Total Artificial Heart Program. "For patients whose hearts are failing and are awaiting transplantation, these devices can be lifesavers. Washington University is the only medical center in the region where patients can receive these devices at this time."
In addition to Ewald, associate professor of medicine, lead investigators in the trial included Nader Moazami, M.D., associate professor of surgery and surgical director of the Cardiac Transplantation and Total Artificial Heart Program at Washington University, and Andrew Boyle, M.D., associate professor of medicine at the University of Minnesota and medical director of Heart Failure, Cardiac Transplantation and Mechanical Circulatory Support. Boyle presented the findings at the ACC meeting.
An LVAD is implanted inside the chest cavity near the heart and is connected to the heart's left ventricle (pumping chamber). It assists the patient's weakened or damaged ventricle in pumping blood through the body. By restoring a normal blood flow, the device improves patients' health. Because it is powered by portable battery packs, patients usually go home while they wait for a heart transplant.
The LVAD used in this study, the VentrAssist, is termed a third-generation heart assist device. Measuring 2.5-inches across and weighing 10 ounces, the pump is considered an improvement over earlier devices because its size and light weight make it suitable for small adults and children. In addition, its pumping mechanism has no contacting parts for improved durability.
Patients who received the LVAD in the study were approved and listed for cardiac transplantation. The study considered the device successful if a patient survived until heart transplantation or survived at least 180 days after the device was implanted and remained qualified for heart transplantation. Eighty-five percent of patients met this measure of success.
Out of 98 patients who received the device, 60 were transplanted, 19 continued to be supported with the device and 19 died. The median time on LVAD support was 131 days. Adverse events reported during the trial included stroke and bleeding, and the number and type of adverse events was similar to other LVADs but better than that of first-generation VAD devices.
Answering standardized questionnaires for patients with heart failure, they reported a significantly improved quality of life after receiving the device, indicating that their heart failure was less apt to interfere with everyday activities such as housework, hobbies or sleeping or to affect their mood, ability to concentrate or energy level.
"Before implantation of the device, 80 percent of these patients were rated class four on the New York Heart Association scale — they were short of breath at rest," Ewald says. "But by six months, 84 percent were in class one or two, meaning their heart failure symptoms were minimal or mild. All of them were able to go home with the device, and that allowed them to rehabilitate themselves — their nutrition improved and they were in better shape, making them better candidates for heart transplantation."
The VentrAssist device pumps blood in a continuous flow in contrast to earlier heart assist pumps that pumped blood in pulses. It contains a spinning rotor that is suspended by blood within the pump housing and magnetically rotated. Since the impeller blades don't touch any part of the pump, the chance of damage to blood cells is lessened. With only one moving part, the pump is resistant to wear.
The positive results from this clinical study mean the VentrAssist will be submitted to the U.S. Food and Drug Administration for approval for use as a bridge to heart transplant. In the interim, Washington University School of Medicine will continue to provide the device to patients as part of a clinical trial.
Doctors here are continuing to enroll patients in a trial of the device as a bridge to transplantation, and they are also testing the device as "destination therapy" to see if the device can function as an alternative to heart transplant by permanently assisting failing hearts. For information about enrolling in the trials call 314-454-7687.
Boyle AJ, Moazami N, John R, Ewald GA, Anyanwu AC, Pinney SP, Desai SS, Burton NA, Teuteberg JJ, Kormos RL, Ascheim DV, Gelijns AC, Parides MK, Joyce LD. The VentrAssist U.S. Pivotal Bridge to Cardiac Transplantation Trial. Presented at 58th annual meeting of the American College of Cardiology, March 30, 2009.
VentrAssist is made by Ventracor. Ewald, Moazami and Boyle report no financial interest in Ventracor.
Funding from Ventracor supported this research.
Washington University School of Medicine's 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked third in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.
Gwen Ericson | EurekAlert!
Further information:
Further reports about: > Artificial pump > Cardiology > LVAD > Transplantation > VentrAssist > blood cell > cardiac > first-generation VAD devices > heart assist devices > heart failure > heart transplantation > implantable heart pump > left ventricular assist device > pumping chamber
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|Publication number
|Publication type
|Application number
|Publication date
|Dec 23, 1997
|Filing date
|Nov 1, 1995
|Priority date
|Nov 1, 1995
|Fee status
|Also published as
|Publication number
|Ralph James Klingenstein
|Original Assignee
|Klingenstein; Ralph James
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (26), Non-Patent Citations (3), Referenced by (55), Classifications (18), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates generally to tubes used for providing fluidic communication with an upper digestive system of a patient and more particularly to an improved nasogastric tube having a modified tip which facilitates insertion of the tube into a stomach or small intestine of a patient via a nasal cavity.
Nasogastric tubes are widely used for patient care to provide a means for removing gastric and other fluids from a patient's stomach or upper small intestine. Once inserted, such tubes can also be used for administering fluids such as medicines or nutritional supplements, although specialized feeding tubes have been developed for this purpose. A conventional nasogastric tube may be manufactured from a clear, elastically flexible polymer having a closed, rounded distal end portion or tip. The tube may have a single bore or lumen; however, a popular design employs a centrally disposed septum to subdivide the tube lumen into a suction lumen and a vent lumen. Fluidic communication between at least one lumen and the patient's stomach is provided by one or more apertures transecting a sidewall of the tube proximate the tip.
A nasogastric tube is conventionally inserted by placing a lubricated tip of the tube into a nostril of the patient and slowly advancing the tube by pushing on the exposed portion thereof. The tube must be sufficiently flexible to negotiate the tortuous, near 180 degree curvature of the nasopharynx, while sufficiently stiff to pass reliably through the hypopharynx and esophagus and into the stomach or small intestine. Insertion of the tube generally results in discomfort to the patient and often causes pain, nose bleeds or other trauma to the nasal cavity. In patients having an abnormality in platelet or coagulation function, such nasal cavity trauma can be particularly troublesome.
Once in the hypopharynx, the tip of the tube is carefully advanced into the esophagus to avoid intubating the patient's larynx. Caution must be exercised throughout advancement of the tube, as the tip of the tube is sufficiently stiff to perforate the wall of the esophagus and enter the mediastinum, requiring immediate recognition and treatment to prevent serious harm to the patient. The tube is advanced a predetermined amount, typically measured by permanent, incremental markings along the tube, correlating to a target location in the patient's digestive system. Actual location of the tip may then be verified by any of a number of methods, including, for example, fluoroscopic inspection of a radiopaque marker on the tube or listening for bubbling in the stomach after injection of air down a lumen of the tube.
Once location of the tip of the tube is verified in the target location, suction may be applied to the lumen to remove fluids or trapped air for diagnostic or therapeutic purposes. Alternatively, a source of medication or nutrition can be coupled with the lumen to supply needed fluid or entrained matter directly to the digestive system, although such practices are uncommon, being generally restricted to emergency situations.
Once properly inserted, nasogastric tubes are routinely left in place over extended periods of time, such as days, even when needed only from time to time. Repeated insertion and removal of the tube is avoided, both due to the risk of harm to the patient, as well as the time and difficulty associated with insertion. Generally, the difficulty encountered during initial insertion and placement of the tube outweigh the continuing discomfort to the patient once the tube is in place.
Attempts to facilitate insertion of the tube, such as by bending the tip into a slight curvature to initially accommodate the curvature of the nasal passage, often prove fruitless. While conventional nasogastric tubes are manufactured from flexible polymeric materials which readily deform under manipulation, such deformation is elastic in nature. The tip regains its free-state, linear contour quickly upon release. If the tip were to be plastically deformed or originally manufactured such that it were to retain an induced curvature or set, passage through the nasopharynx may be facilitated; however, passage of the tip beyond the nasopharynx, into the hypopharynx and esophagus, would be rendered substantially more difficult if not altogether impractical.
The design of nasogastric tubes typically balances competing needs for a flexible apparatus which is able to negotiate the tortuous path to a patient's stomach via the nasal passage while maintaining sufficient structural integrity to prevent sidewall collapse and blockage of the lumen when suction is applied. Further, the suction lumen must be of sufficient cross-sectional area and the tube of relatively small external diameter to support adequate volumetric flow rates while minimizing discomfort to the patient. Yet further, the tube must be sufficiently stiff so as to be capable of reliable advancement when an exposed portion thereof is pushed upon. This stiffness, however, is problematic insofar as stiffer tubes expose the patient to increased risk of trauma of the nasal cavity and perforation of the esophagus or other soft tissue.
The improved nasogastric tube includes a tube body having a lumen formed by a sidewall, the body being manufactured of a material and configured in a predetermined manner to exhibit a first stiffness or column strength. The terms stiffness and column strength are used interchangeably herein, being commonly defined as resistance to buckling when subjected to a substantially centrally disposed, longitudinal load. The greater the stiffness or column strength, the greater the critical load which can be stably supported by the element, and beyond which the element buckles or collapses.
Coupled with a distal end portion of the tube body along a transition zone is a tip configured to provide a second stiffness or column strength, the second column strength being less than the first column strength such that the tip collapses at a lower critical load. During insertion of the tube through the nasopharynx and upper digestive system of a patient, upon encountering tissue, bone, cartilage or other body structure along the direction of advancement, the tip preferentially buckles before the tube to prevent trauma to the nasal cavity or perforation of soft tissue. Further, given the physical contour of the nasopharynx and hypopharynx, as the tip buckles, the tip and tube body are passively oriented toward the body passage lumen, unlike conventional nasogastric tubes which tend to displace or perforate or otherwise traumatize body structure.
The tip may be manufactured from a relatively soft, flexible material which bends or buckles toward the body passage lumen upon advancement against body structure. Further, the resultant blunt tip is even less prone to cause trauma to or perforation of proximate body structure. The remainder of the tube may be manufactured of a relatively stiff material. During insertion, the more compliant tip reduces the likelihood of discomfort and trauma by providing a lumen-seeking function, bending or collapsing upon encountering body structure and passively steering the nasogastric tube through the nasal passage, along the esophagus and into the stomach. Any deviation in travel from the centerline of the esophageal lumen during advancement of the tip is automatically passively corrected.
The tip mates with the tube body along a transition zone using a bonded male/female connection which will generally exhibit a third stiffness or column strength. Depending on the particular configuration employed, the transition zone stiffness may be advantageously tailored to be greater than that of the tip and less than that of the tube body thereby providing an intermediate transitional stiffness to further facilitate the lumen-seeking function of the tube.
The tube may advantageously include a coiled wire reinforcement member which is either embedded in the tip or surrounds the tip, being anchored in the transition zone. The reinforcement member may be primarily employed to modify the stiffness of the tip, for example to enhance resistance to buckling while permitting controlled bending of the tip once buckling occurs. The wire member may also act as a fail-safe, preventing release of the tip in a patient's body in the event of inadvertent failure of the connection between the tip and the tube body.
Alternately, the tip may be manufactured from the same material as the tube body and may advantageously be formed integrally with the tube body, especially where a hollow tip is desired. In this embodiment, column strength may be tailored by modifying the geometry of the tip to reduce the moment of inertia and related critical buckling load thereof relative to those of the tube body. In this manner, preferential buckling of the tip may be achieved in a tube having unitary construction. Further, instead of having uniform column strength, the tip and/or tube may exhibit incrementally or gradually varying column strength as desired. For example, column strength may be varied to provide for increasing stiffness as a function of distance from the end of the tip. In tubes with either integral or bonded tips, the tips may be solid or hollow; cylindrical, frustoconical, tapered, bulbous, pleated or necked; symmetrical or asymmetrical; and may include one or more apertures in fluid communication with the lumen of the tube.
The invention in accordance with preferred and exemplary embodiments, together with further advantages thereof, is more particularly described in the following detailed description taken in conjunction with the accompanying drawings in which:
FIG. 1 is a schematic, partial cutaway side view of a patient fitted with a nasogastric tube in accordance with a preferred embodiment of the present invention;
FIG. 2A is a schematic, longitudinal sectional view of the tube body distal end portion and tip depicted in FIG. 1, generally in accordance with a preferred embodiment of the present invention;
FIG. 2B is an enlarged schematic, cross-sectional view of the tube body of FIG. 2A taken along line 2B--2B in accordance with a preferred embodiment of the present invention;
FIG. 2C is an enlarged schematic, cross-sectional view of a tube body in accordance with another embodiment of the present invention;
FIG. 2D is a schematic, longitudinal sectional view of the transition zone depicted in FIG. 2A in accordance with a preferred embodiment of the present invention;
FIG. 2E is a schematic, longitudinal sectional view of the transition zone depicted in FIG. 2A in accordance with an alternate preferred embodiment of the present invention;
FIG. 3 is an enlarged, schematic partial cutaway view of a nasopharynx of a patient during insertion and advancement of the tube of FIG. 2A in accordance with an exemplary embodiment of the present invention;
FIGS. 4AA-4CB are schematic, plan and end views of three cylindrical tip configurations in accordance with various embodiments of the present invention;
FIGS. 5A-5B are schematic, plan and end views of a frustoconical tip configuration in accordance with a preferred embodiment of the present invention;
FIGS. 6AA-6BB are schematic, plan and end views of two tapered tip configurations in accordance with other preferred and exemplary embodiments of the present invention;
FIGS. 7AA-7BB are schematic, plan and end views of two bulbous tip configurations in accordance with various embodiments of the present invention;
FIGS. 8A-8B are schematic, plan and end views of a pleated tip configuration in accordance with one embodiment of the present invention;
FIGS. 9AA-9CB are schematic, plan and end views of three necked tip configurations in accordance with various embodiments of the present invention; and
FIG. 10 is a schematic, longitudinal sectional view of the tube body depicted in FIG. 2A, generally in accordance with an alternate embodiment of the present invention.
Depicted in FIG. 1 is a schematic, partial cutaway side view of an upper torso and cranium of a patient 10 fitted with a flexible, substantially cylindrical nasogastric tube 12 in accordance with an exemplary embodiment of the present invention. The tube 12 passes serially through nostril 14, nasopharynx 16, hypopharynx 18, and esophagus 20 with tube tip 22 terminating in stomach 24. Alternatively, the tube 12 may be advanced further so that the tip 22 is disposed in an upper portion of the small intestine 26, although in practice, such procedures entail additional difficulty. Care is exercised during advancement of the tube 12 to prevent trauma to the nasopharynx 16, intubation of the larynx 28 and/or perforation of the esophagus 20.
As best seen in FIG. 2A, the tube 12 includes a substantially cylindrical, flexible tube body 30 formed by a sidewall 32 which defines a centrally disposed, longitudinally extending bore or lumen 34. A distal end portion 36 of tube body 30 includes at least one aperture 38 transecting the sidewall 32 to provide fluidic communication between the lumen 34 and an environment in which the end portion 36 is disposed. Two diametrically opposed apertures 38 are depicted; however, the number, size, location, shape, and orientation of the apertures 38 may be selected in accordance with conventional practice by those skilled in the art of nasogastric tube design.
Coupled with the end portion 36 along a transition zone 40 is a substantially cylindrical, flexible tip 22 having a smooth, generally spherical end 44. Tip 22 and numerous alternate tip configurations are depicted in FIGS. 4AA-9CB inclusive. It is contemplated that a gently tapered tip configuration, such as that depicted in FIG. 6AA, is preferred; however, tip 22 may be considered representative for purposes of explanation.
Reliable coupling of the tip 22 to the distal end 36 is afforded by inserting a centrally disposed, longitudinally extending leader 46 of the tip 22 into the lumen 34. The leader 46 may be sized to match a nominal diameter of the lumen 34 or preferably may be an interference fit therewith. The leader 46 and lumen 34 together form a male/female connection which may be bonded, friction welded or otherwise permanently coupled along mating surfaces thereby forming an inseparable assembly. The manner of coupling may be selected in accordance with conventional practice for the materials chosen for the respective elements. As depicted herein, the length of the tip 22, LT, is substantially equal to the length of the transition zone 40, LZ, although values may be selected to achieve desired respective column strengths as will be discussed in more detail hereinbelow. Alternatively, the tip 22 may be molded or otherwise formed in place along the distal end 36.
In either embodiment, a coiled wire reinforcement member 48 may be advantageously embedded or anchored in both the tip 22 and sidewall 32. As will be discussed in greater detail hereinbelow, the reinforcement member 48 may be employed to modify the stiffness of the tip 22 and transition zone 40 to achieve desired resistance to buckling through selection of coil diameter and pitch values. Additionally, in the event the coupling between the tip 22 and distal end 36 fails during manipulation of the tube 12 in a patient 10, the tip 22 is retained and may be readily extracted along with the tube 12. Wire diameter and material may be selected to provide sufficient structural integrity for anticipated extraction loads.
By coupling the tip 22 to the distal end 36 in any of the manners described, the tube 12 exhibits a uniform, smoothly contoured external configuration without steps, ridges or other local discontinuities which would tend to render insertion and removal of the tube 12 in a patient 10 more difficult. Respective outer diameters of the tip, DT, and the tube body, DB, have similar values which are substantially constant along respective lengths thereof; however, such values may vary as a function of position to vary stiffness as will be discussed in greater detail hereinbelow.
The transition zone 40 functions to transition between the stiffness and geometry of the tip 22 and those of the tube body 30. As will be discussed with respect to FIG. 10, the tube body 30 may also incorporate additional body transition zones 140 to transition between sections of tube body 30' having differing respective column strengths and/or geometries, further facilitating the lumen-seeking function of the tube 12.
FIG. 2B is an enlarged schematic, cross-sectional view of the tube body 30 of FIG. 2A taken along line 2B--2B. Solely a single lumen 34 is defined by the sidewall 32, the diameter of which is designated DL. FIG. 2C depicts a similar view of a tube body 130 having a suction lumen 134 and a vent lumen 234 defined by sidewall 132 and a generally diametrically disposed septum wall 232. Clearly, more than one septum 232 may be provided to further subdivide each lumen 134, 234 and placement of the septa may yield lumens of different cross-sectional contour and area, as desired.
Column strength of an element, defined herein as resistance of the element to buckling, is a function of a variety of factors including the geometry and material properties of the element as well as the end conditions to which the element is subjected. Taking the tube 12 of FIG. 2A as an example, the configuration of each section of the tube 12 may be modeled to develop a critical load, PCRIT, below which that section of the tube 12 is structurally stable. Above PCRIT, that section of the tube 12 is unable to support the load and the section will buckle.
Analytically, for a column subjected to a centrally-disposed, longitudinal load, elastic buckling occurs at loads greater than PCRIT, with PCRIT being defined as:
P.sub.CRIT =cEI/L.sup.2 (1)
where E is the modulus of elasticity of the column material, I is the moment of inertia of the column about its longitudinal axis, L is the unsupported length of the column and c is a factor employed to account for end conditions. Conventionally modeled column end conditions include, for example, various combinations of free, clamped and hinged configurations. Given the physical constraints on the tube 12 as it is inserted and advanced in a patient's body, the end conditions may be modeled as a clamped-free column. Substituting the associated value of π2 /4 for c for a clamped-free column in critical load equation (1) yields:
P.sub.CRIT =π.sup.2 EI/4L.sup.2. (2)
Regarding tube 12, the tube body 30 may be modeled a hollow circular cylinder, the transition zone 40 as a solid, circular cylinder and the tip 22 as another solid, circular cylinder. Subscript "T " refers to the tip 22 subscript "B " to the body 30, subscript "L " to the lumen 34 and subscript "Z " to the transition zone 40.
Looking first to the tip 22, the moment of inertia of the solid, circular, cylindrical tip, IT, may be defined as:
I.sub.T =πm.sub.T L.sub.T D.sub.T.sup.4 /32 (3)
where mT is the mass per unit volume of the tip, LT is the length of the tip and DT is the outer diameter of the tip as shown in FIG. 2A. Substituting moment of inertia equation (3) for I in critical load equation (2) yields:
P.sub.TCRIT =π.sup.3 m.sub.T E.sub.T D.sub.T.sup.4 /128L.sub.T.(4)
To calculate the critical tube body load, PBCRIT, the tube body 30 has a moment of inertia, IB, defined as that for a hollow circular cylinder:
I.sub.B =πm.sub.B L.sub.B (D.sub.B.sup.4 -D.sub.L.sup.4)/32(5)
where mB is the mass per unit volume of the body, LB is the unsupported length of the body, DB is the outer diameter of the body and DL is the diameter of the lumen as shown in FIG. 2A. Substituting into critical load equation (2) yields:
P.sub.BCRIT =π.sup.3 m.sub.B E.sub.B (D.sub.B.sup.4 -D.sub.L.sup.4)/128L.sub.B. (6)
Lastly, the critical load for the solid, circular cylinder transition zone 40 may be defined by:
P.sub.ZCRIT =π.sup.3 m.sub.Z E.sub.Z D.sub.Z.sup.4 /128L.sub.Z(7)
where the modulus of elasticity of the transition zone 40, EZ, is a combination of the moduli of the tip 22 and the body 30 and which may be conventionally analytically or empirically determined. For the configuration of tube 12 depicted in FIG. 2A, PZCRIT will necessarily be greater than PBCRIT and therefore need not be considered further. Other preferred embodiments of transition zone 40 are discussed hereinbelow with respect to FIGS. 2D and 2E in which the stiffness of the transition zone 40 may be intermediate between that of the tip 22 and tube body 30 or in which the transition zone 40 includes a plurality of transition zones of graded stiffness.
Clearly, a designer may select any desired combination of materials and geometries to satisfy the requirement that the tip 22 preferentially buckle before the tube body 30, expressed in equation form as:
P.sub.TCRIT <P.sub.BCRIT. (8)
In this manner, the lumen-seeking capability of the tube is enabled.
While this analytical modeling does not account for features such as apertures 38 through the tube body sidewall 32, the inclusion of such features in the tube body 30, for example, will tend to reduce the resultant resistance to buckling and the critical load, PBCRIT ; therefore, sufficient margin should be provided in the design of any tube 12 to accommodate for such structural discontinuities. Generally, the greater the number, size and local density of the apertures 38, the greater the margin that should be provided. Given the analytical guidelines disclosed hereinabove, a tube 12 may be readily designed by those skilled in the art without undue experimentation. Further, since manufacture and testing of contemplated combinations of materials and geometries to verify preferential buckling may be readily accomplished at modest cost, empirical results may be used to guide modification and tailoring of the tube 12 for particular aperture patterns and combinations which would otherwise entail more complex analytical modeling.
Where, as in tube 12, the outer diameters of both the tube body 30 and tip 22 are equivalent and constant, substituting respective tip and tube body critical load equations (4) and (6) into preferential buckling equation (8) and simplifying yields:
m.sub.T E.sub.T /L.sub.T <m.sub.B E.sub.B (1-D.sub.L.sup.4 /D.sub.B.sup.4)/L.sub.B. (9)
A designer could meet the preferential buckling criteria of equation (9) in a variety of ways. For example, a designer could provide a tip 22 having a longitudinal length, LT, greater than the anticipated unsupported longitudinal length of the body 30, LB, during insertion of the tube 12 in a patient 10. Since tip critical buckling load, PTCRIT, varies with the inverse of longitudinal length, an increase in tip length, LT, reduces PTCRIT. Alternately or additionally, PTCRIT may be reduced relative to PBCRIT by employing a tip material having relatively lower mass per unit volume, mT, than body material mass per unit volume, mB, and/or a tip material having a relatively lower modulus of elasticity ET than body modulus of elasticity EB. Yet further, PBCRIT may be increased by increasing thickness of the sidewall 32 and thereby decreasing lumen diameter, DL, in the tube body 30.
FIG. 2D depicts a schematic, longitudinal sectional view of a transition zone 140 similar to that depicted in FIG. 2A in accordance with a preferred embodiment of the present invention. Instead of coupling the tip 22 to the tube body 30 by disposing tip leader 46 in tube lumen 34, tube body 230 includes a generally centrally disposed tube leader 146 disposed in a suitably sized bore 56 of tip 122. Tube lumen 334 is preferably truncated in advance of the transition zone 140; however, in an alternate embodiment, lumen 334 may pass therethrough. In accordance with the analytical model outlined hereinabove, materials and geometries may be selected such that the critical load of the transition zone 140, above which the zone 140 would buckle, is intermediate between that of the tip 122 and tube body 230. In this manner, the buckling strength of this overall configuration will generally incrementally increase as a function of distance from the end 144 of the tip 122. In other words, as loading is increased, the tip 122 would buckle first, the intermediate zone 140 would buckle next and the tube body 230 thereafter.
If additional tailoring of incremental buckling strength of the tip 122 is desired, additional tip transition zones 240a may be employed. For example, FIG. 2E depicts a schematic, longitudinal sectional view of multiple transition zones 240, 240a in accordance with an alternate preferred embodiment of the present invention, two such zones 240, 240a being depicted herein. Tip 222 is comprised of two members 222a, 222b which are coupled by a male/female connection along tip transition zone 240a, although any other suitable method of coupling, as described hereinabove, may be employed if desired. Tip member 222b is coupled to tube body 330 by similar means along transition zone 240. Again, by selecting materials and geometries in accordance with the analytical model, respective critical loads of serially arranged tip member 222a, tip transition zone 240a, tip member 222b, transition zone 240, and tube body 330 may be tailored to provide incrementally increasing resistance to buckling as a function of distance from end 244. Any number of tip transition zones 240a, and proximate tip members 222b may be employed to further refine and tailor buckling characteristics to achieve a desired result.
Referring now to FIG. 3, depicted is an enlarged, schematic partial cutaway view of the nasopharynx 16 of the patient 10 depicted in FIG. 1 during insertion and advancement of the tube 12. In free state, the tube body 30 and tip 22 are substantially straight and collinear. Upon encountering body structure, such as nasal bone 50, continued advancement of the tube 12 causes buckling of the tip 22' as depicted in phantom. The tube body 30 retains structural integrity, remaining substantially straight, to facilitate manipulation of the exposed portion of the tube 12. As the tube is advanced further, the buckled tip 22' tends to reduce local pressure on the nasal bone 50 by increasing the surface area upon which the force applied to the tube 12 impinges. Further, the buckled tip 22' redirects the direction of the applied force generally along the direction of buckling, passively steering the distal end portion 30 toward the hypopharynx 18 and esophagus 20 as desired. As the tube 12 is advanced further, proximate tissue supports the tube body 30 permitting the tip 22 to regain its free state, linear configuration until other body structure is encountered.
In addition to merely subjecting the exposed portion of the tube 12 to a longitudinal advancing force, the tube 12 may be retracted or twisted, as depicted by the arrows shown generally at 52, to further direct the tip 22 and end portion 30 in a desired direction. Additionally, the tube 12 may be incrementally advanced and retracted repeatedly by a technique known as dithering. Such a technique may be employed advantageously when the tip 22 impinges upon body structure such as nasal bone 50 at an angle, as will almost always be the case. By dithering the exposed portion of the tube 12, the tip 22 will tend to alternately buckle and straighten, incrementally moving along the nasal bone 50 and through the nasopharynx 16 permitting the tube 12 to be advanced. Once in the hypopharynx 18, intubation of the larynx 28 by the tube 12 may be avoided by repeated swallowing by the patient 10 as is conventionally known. As the tube 12 is further advanced along the esophagus 20, any deviation in travel from the centerline of the esophageal lumen causes the tip 22 to buckle. Again, the buckled tip 22' both redirects the relatively stiff distal end 36 away from the esophageal wall, toward the esophageal lumen, and reduces pressure on the wall tissue, significantly reducing the likelihood and risk of perforation thereof. Once the end portion 36 has reached the target destination in the stomach 24, for example, and position is confirmed, suction may be applied to tube lumen 34 and fluids extracted conventionally.
The embodiment of the invention depicted in FIG. 2A provides a general purpose nasogastric tube designed for universal use. In an exemplary embodiment, tube body 30 and tip 22 may be manufactured from medical grade polyurethane or other polymer or material which may be sterilized and which is stable in a digestive system environment for extended periods. For a tube 12 having a tube body outer diameter, DB, of about 6.0 mm, a nominal lumen diameter, DL, of about 3.0 mm and an overall length of about 120 cm, the tip 22 may have a similar outer diameter, DT, of about 6.0 mm and a length, LT, of about 5.0 cm. The transition zone 40 may have a similar length, LZ, of about 5.0 cm, more or less, with the tip leader 46 being inserted into the lumen 34 with a slight interference fit and coupled to the tube body 30 by bonding with an epoxy resin. As discussed hereinabove, sizing of the various elements of the tube 12 as well as the method of bonding depends upon the properties of selected material(s). If a coiled wire reinforcement member 48 is utilized, a preferred material is medical grade stainless steel.
The outer diameter of the tube body 30, commonly referred to by a measurement standard known as the French size which is about three times the diameter value in millimeters, may be increased or decreased as desired to accommodate patients of all body sizes; however, since the tube body critical buckling load does not vary linearly with lumen diameter, DL, scaling may not be equally proportional for all tube features. For general purpose tubes 12, tube body diameter, DB, will generally be in the range of about 6 Fr. to 18 Fr., corresponding to values of about 2 mm to about 6 mm; however smaller and larger diameter tubes 12 are considered to fall within the scope of the invention. Lumen diameter, DL, may nominally be about one half the value of DB selected; however, values as low as about 10% or less or as high as about 90% or more of DB are possible, depending on the properties of the selected materials. Tip diameter, DT, is nominally matched with body diameter, DB ; however, as will become apparent, various non-cylindrical tip configurations with respective diameters varying as a function of tip length are contemplated. Depending on the configuration selected, DT may range from values greater than DB to a value approaching zero. Tip length, LT, may also vary from values of less than about 1 cm to values greater than about 10 cm or more. Tube body length, LB, may be any value and transition zone length, LZ, is generally the result of the coupling method employed between the tip 22 and tube body 30. Nominally the same as tip length, LT, transition zone length, LZ, may approach zero for those tubes 12 having tips 22 integrally formed with the tube body 30 to values greater than LT to ensure reliable coupling, as necessary.
In addition to scaling the size of the tube 12 to accommodate different patient body sizes, a designer has great leeway in varying relative column strengths. For example, soft, nominal and stiff tips 22 may be provided in each size tube 12 to be used at the discretion of the medical practitioner depending on the frailty of the patient 10. In all cases, the tip 22 preferentially buckles before the tube body 30.
The scope of the invention is not limited to the cylindrical tip configuration depicted in FIG. 2A. Insertion of a tube 12 in a patient 10 having particular characteristics may be facilitated where the tip 22 has an asymmetric or non-cylindrical tip configuration. For example, a patient having an anomalous nasal structure or a displaced esophageal lumen may benefit from a tube having a tip 22 with a reduced outer diameter, DT, relative to that of the body 30. Further, since an asymmetric tip will generally have a tendency to buckle repeatably in the same direction, such a feature may be advantageously employed in particularly troublesome situations where symmetrical, non-directional tip configurations prove difficult to insert.
The remaining figures depict additional tip configurations which may be used depending, for example, on the age, infirmity or physical characteristics of a patient 10. Depending on the particular configuration, such tips 22 may be separate elements coupled to the tube body 30 in any manner described hereinabove. Alternatively, in those embodiments exhibiting sufficiently attenuated column strength, the tips 22 may be formed integrally with the tube body 30, obviating the bonded connection. The lumen 34 of the tube body 30 may be in fluidic communication with a hollow feature of the tip 22 or may be blocked by the tip 22, as desired. Further, any hollow feature of the tip 22 need not be in fluidic communication with the tube lumen 34, being employed primarily to tailor tip column strength.
FIGS. 4AA-4CB are schematic, plan and end views of working ends of three cylindrical tip configurations in accordance with various embodiments of the present invention. FIGS. 4AA-4AB depict the solid, cylindrical tip 22 of tube 12 shown in FIG. 2A. The tip 22 has a uniform diameter, circular cross-section and generally spherical end 44. FIGS. 4BA-4BB an alternate embodiment solid, cylindrical tip 22a. The tip 22a has a uniform diameter, circular cross-section and generally truncated end 44a. FIGS. 4CA-4CB depict an alternate embodiment hollow, cylindrical tip 22b. The tip 22b has an annular cross-section with uniform inner and outer diameters and a generally truncated end 44b. Combinations of features depicted in these various embodiments are also contemplated. For example, tip 22 of FIGS. 4AA-4AB could be hollow.
FIGS. 5A-5B are schematic, plan and end views of a solid, frustoconical cylindrical tip 22c in accordance with another embodiment of the present invention. Tip 22c has a circular cross-section of decreasing area as a function of length and a generally truncated end 44c.
FIGS. 6AA-6BB are schematic, plan and end views of two tapered tip configurations in accordance with still further embodiments of the present invention. FIGS. 6AA-6AB depict a preferred embodiment solid, gently symmetrically tapered, conical tip 22d. Rate of taper or slope may be selected as desired. Tip 22d has a circular cross-section of gently decreasing area as a function of length and a generally blunt, radiused end 44d. FIGS. 6BA-6BB depict a hollow, asymmetrically tapered tip 22e. Tip 22e has an annular cross-section with decreasing cross-sectional area as a function of length and a generally blunt, radiused end 44e.
FIGS. 7AA-7BB are schematic, plan and end views of two bulbous tip configurations in accordance with additional embodiments of the present invention. FIGS. 7AA-7AB depict a solid, symmetrical bulbous tip 22f. Tip 22f has a circular cross-section of increasing then decreasing area as a function of length and an optional, generally blunt, truncated end 44f having a circular cross-section. FIGS. 7BA-7BB depict a hollow, symmetrical bulbous tip 22g. Tip 22g has an annular cross-section of increasing then decreasing area as a function of length and a generally blunt, truncated end 44g.
FIGS. 8A-8B are schematic, plan and end views of a hollow, pleated tip 22h in accordance with another embodiment of the present invention. Tip 22h has a multi-lobed cross-section of substantially constant area and a closed, generally spherical end 44h. When tip 22h buckles upon meeting body structure, the tip 22h may buckle asymmetrically, bending away from its longitudinal axis, or symmetrically, essentially shortening its overall length while the lobed sidewall expands radially outwardly. The mode of buckling may be influenced, for example, by varying the number and length of the pleats and the thickness of the sidewall.
Lastly, FIGS. 9AA-9CB are schematic, plan and end views of three necked tip configurations in accordance with further embodiments of the present invention. FIGS. 9AA-9AB depict a solid, symmetrical necked tip 22i. Tip 22i has a circular cross-section of rapidly decreasing then constant area as a function of length and a truncated end 44i having a circular cross-section. FIGS. 9BA-9BB depict a solid, symmetrical necked tip 22j. Tip 22j has an circular cross-section of gradually decreasing then constant area as a function of length and a spherical end 44j. FIGS. 9CA-9CB depict a hollow, asymmetrical necked tip 22k. Tip 22k has a generally annular cross-section with a solid extension 42 of circular cross-section longitudinally extending from a region of the annulus, the extension 42 having a spherical end 44k.
While there have been described herein what are to be considered exemplary and preferred embodiments of the present invention, other modifications of the invention will become apparent to those skilled in the art from the teachings herein. For example, various permutations of the tips 22 and ends 44 depicted may be employed to achieve a desired configuration to suit a particular application. Further, any of the tips 22 may be made hollow, fully or in part, to modify the column stiffness thereof or provide for fluidic extraction therethrough. Also, instead of being fully embedded within the sidewall 32 and tip 22, optional coiled wire reinforcement member 48 may be used to externally wrap at least a portion of the transition zone 40 and/or tip 22. Yet further, the coil 48 may be tightly or loosely wrapped and the pitch may vary as a function of longitudinal location to provide varying column strength along the tip 22. As may be readily appreciated, hollow tip wall thickness may also vary as a function of tip length to vary tip column strength. Configurations other than coils and materials other than wire may also be employed. For example, wire or plastic rings, or longitudinally disposed slivers of a desired material may be embedded in the tip 22. Instead of circular or annular cross-sections, tips 22 may have oval, contoured or polygonal cross-sections, with or without lumen 34 or aperture(s) 38. A lumen 34 of a tip 22 need not have the same diameter as the tube lumen 34 and any such tip lumen 34 need not have a circular cross-section. Multiple tip lumens 34 may also be provided, as desired. Asymmetric tips 22 may be advantageously employed where it is desirable for the tip 22 to buckle repeatably in a predetermined direction relative to the tube body 30.
Still other modifications are contemplated. For example, a tube 12 may be provided with a tip 22 which is relatively soft proximate the end 44 thereof and which exhibits increasing stiffness as a function of tip length as the transition zone is approached. The tube body 30 may also include a removable wire stiffener which is temporarily disposed in a lumen 34 and extends along substantially the entire length of the tube body 30, providing additional column strength to the tube body 30 during insertion and advancement. For this configuration, the calculation of body critical load, PBCRIT, should include the effect of the stiffener. The tube body and/or tip may further include a radiopaque stripe, band or other marker to facilitate fluoroscopic verification of the location of the tube 12 in the body of a patient. An exemplary radiopaque marker 54 is depicted in the tip 22 in FIG. 2A.
Yet further, as depicted in FIG. 10, instead of solely a single transition zone 40, which is disposed between the tip 22 and tube body 30, the tube body 30 may include one or more additional body transition zones 340. The body transition zones 340 may be disposed along the length of the tube body 30 between tube body sections 30' having differing respective column strengths. In this manner, the tube body 30 may exhibit increasing stiffness, for example, as a function of distance from the tip 22, thereby facilitating the lumen-seeking capability of the tube 12. The multiple sections 30' may be bonded, friction welded, or otherwise permanently coupled along mating transition zone surfaces which may include annular butt joints, male/female connections (as depicted), or other suitable arrangements as desired. Typically, the tube lumen 34 passes substantially unrestricted in cross-sectional area through the body transition zones 340; however, localized deviations may be desirable to enhance coupling strength, modify body transition zone column strength, or facilitate manufacture. Material and geometry of each section 30' may be selected in accordance with the critical load criteria discussed hereinabove to achieve the respective buckling strengths desired.
It is therefore desired to be secured in the appended claims all such modifications as fall within the true spirit and scope of the invention. Accordingly, what is desired to be secured by Letters Patent is the invention as defined and differentiated in the following claims.
|Cited Patent
|Filing date
|Publication date
|Mar 16, 1937
|Aug 20, 1940
|Floyd C Hendrickson
|Nov 20, 1940
|Dec 30, 1941
|Wardlyn Corp
|May 15, 1981
|May 31, 1983
|Ruiz Oscar F
|Angiographic catheter with soft tip end
|Sep 16, 1981
|Sep 6, 1983
|The Kendall Company
|Cannula with soft tip
|Sep 13, 1982
|May 14, 1985
|Kaufman Jack W
|Medical device
|Jul 28, 1983
|Dec 17, 1985
|Catheter Technology Corporation
|Apparatus for intravenous therapy and hyperalimentation
|Feb 18, 1983
|Jan 7, 1986
|Mallinckrodt, Inc.
|Fused flexible tip catheter
|May 6, 1985
|Jun 10, 1986
|Viridian, Inc.
|Non-occluding high flow enteral feeding tube
|May 12, 1986
|Apr 5, 1988
|H. P. Bruemmer Corp.
|Nasogastric tube antireflux valve
|Aug 14, 1987
|Sep 5, 1989
|C. R. Bard, Inc.
|Soft tip catheter
|Jan 3, 1989
|Dec 12, 1989
|C. R. Bard, Inc.
|Steerable guidewire with soft adjustable tip
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|Dec 12, 1989
|Baxter Travenol Laboratories, Inc.
|Soft tip catheter
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|Dandeneau James V
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|Med Institute, Inc.
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|May 21, 1991
|Tri-State Hospital Supply Corp.
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|Jan 7, 1992
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|Mar 31, 1992
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|Catheter with independent proximal and distal control
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|Oct 1, 1996
|Mccue; Michael
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|Sep 16, 1980
|Mar 25, 1982
|Braun Melsungen Ag
|Body cavity drainage tube - has flexible supporting member for strainer secured to end of suction hose
|Feb 12, 1986
|Aug 20, 1986
|TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION
|Dec 4, 1989
|May 4, 1994
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|Rapidly exchangeable coronary catheter
|Title not available
|Title not available
|Title not available
|Counterpart PCT International Application No. PCT/US96/17496 IPEA Search Report (actual completion date 26 Feb. 1997).
|Thomas J. Lardner et al., "An Introduction To The Mechanics of Solids", Second Edition (McGraw-Hill, Inc.) (1978), 582-590 and 595-596.
|Thomas J. Lardner et al., An Introduction To The Mechanics of Solids , Second Edition (McGraw Hill, Inc.) (1978), 582 590 and 595 596.
|Citing Patent
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|Reduced profile delivery sheath for use in interventional procedures
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|Sep 7, 2004
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|Applicator for insertion of cargo into a body cavity
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|Flexible delivery system
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|Oct 13, 2009
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|Oct 20, 2009
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|May 30, 2006
|May 18, 2010
|Boston Scientific Scimed, Inc.
|Medical devices and related systems and methods
|Oct 19, 2007
|Jul 27, 2010
|B. Braun Melsungen Ag
|May 25, 2007
|Jun 28, 2011
|Iq Medical Devices, Llc
|Catheter with variable attachment means
|Dec 24, 2003
|Jul 5, 2011
|Abbott Laboratories Vascular Enterprises Limited
|Catheter and method of manufacturing same
|Oct 12, 2005
|Jul 31, 2012
|Remedaese, Inc.
|Nosebleed lip pack
|Dec 16, 2004
|Jan 8, 2013
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|Mar 29, 2011
|Apr 23, 2013
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|Jul 30, 2012
|Feb 23, 2016
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|Nosebleed lip pack
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|Philip J. Dye
|Mar 14, 2016
|Oct 25, 2016
|Philip J. Dye
|May 28, 2015
|Nov 8, 2016
|Philip J. Dye
|Intermittent urinary catheter
|Apr 29, 2009
|Mar 21, 2017
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|Oct 7, 2013
|May 30, 2017
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|Jan 6, 2016
|Sep 12, 2017
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|Sep 14, 2012
|Sep 12, 2017
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|Sep 19, 2017
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|System and method for synchronizing energy delivery to the cardiac rhythm
|Mar 29, 2002
|Nov 21, 2002
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|Medical instrument with an atraumatic end
|Jun 18, 2002
|Jan 23, 2003
|Udo Goebel
|Aug 28, 2003
|Feb 26, 2004
|Burkett David H.
|Wire joint and method
|Dec 24, 2003
|Oct 21, 2004
|Abbott Laboratories Vascular Enterprises Limited
|Catheter and method of manufacturing same
|May 28, 2003
|Dec 2, 2004
|Hogle Gregory A.
|Inflatable nasal packing device with two non-elastic, flexible bags oversized relative to nasal cavities
|Feb 4, 2004
|Aug 4, 2005
|Wood Scott D.
|Gastric aspirate intestinal feeding tube
|Oct 12, 2005
|Feb 9, 2006
|Rix Amy D
|Nosebleed lip pack
|Sep 8, 2004
|Mar 9, 2006
|Beth Israel Deaconess Medical Center, Inc.
|Color-coded medical tubes and post-insertion monitoring thereof
|Dec 16, 2004
|Jun 22, 2006
|Smiths Medical Asd, Inc.
|Catheter with direction orientation
|Dec 16, 2004
|Jun 22, 2006
|Smiths Medical Asd, Inc.
|Catheter with direction orientation
|May 11, 2006
|Nov 15, 2007
|Kourosh Kojouri
|Nasopharyngeal sheath for nasogastric intubation
|Oct 19, 2007
|Feb 21, 2008
|B. Braun Melsungen Ag
|May 30, 2006
|Apr 24, 2008
|Spencer Steven M
|Medical devices and related systems and methods
|Mar 10, 2008
|Sep 11, 2008
|Seydel Anna S
|Intubation devices and methods of use thereof
|Jun 10, 2009
|Oct 1, 2009
|Robert Kotler
|Device and Method for Maintaining Unobstructed Nasal Passageways after Nasal Surgery
|Sep 14, 2012
|Jan 23, 2014
|Niels A. Abt
|Soft tip cannula
|Jun 20, 2013
|Dec 25, 2014
|Philip J. Dye
|Nov 26, 2014
|Jan 11, 2017
|Applied Medical Tech Inc
|Bridle catheter
|Mar 20, 2001
|Oct 4, 2001
|Endosonics Corporation
|A catheter having a spear shaped tip
|Mar 29, 2002
|Oct 24, 2002
|Cytyc Health Corporation
|Medical instrument with an atraumatic end
|Mar 29, 2002
|Jan 3, 2003
|Cytyc Health Corp
|Medical instrument with an atraumatic end
|Nov 20, 2003
|Jun 10, 2004
|Westf�lische Wilhelms-Universit�t M�nster
|Gastric tube and method for introducing the same
|Jul 19, 2012
|Jan 24, 2013
|Svip 7 Llc
|Devices and methods for treating sleep disordered breathing
|Aug 19, 2013
|Jun 11, 2015
|Chris Salvino
|Improved nasogastric tube
|Nov 26, 2014
|Jun 18, 2015
|Applied Medical Technology, Inc.
|Bridle catheter
|U.S. Classification
|604/525, 604/500, 604/528, 604/264, 606/196
|International Classification
|Cooperative Classification
|European Classification
|Jun 22, 2001
|Fee payment
Year of fee payment: 4
|Jul 13, 2005
|Maintenance fee reminder mailed
|Dec 23, 2005
|Lapse for failure to pay maintenance fees
|Feb 21, 2006
|Expired due to failure to pay maintenance fee
Effective date: 20051223


text:
Todays football scores and fixtures
Stream NFL SUNDAY TICKET games live online with - now available in more cities and on more streaming devices todags ever. Baresi and Beckenbauer both are sweeper and I need one more center-back to reserve Bobby Moore like Figueroa who is also a better defensive player todays football scores and fixtures Scirea. In the present. Detachable cleats are excellent for those required to play on a variety of surfaces. So you think baseball is boring. ) University. If you are not too much convinced with what is written, you can always search for another. Baylor said it has been in conversation for months with the woman's legal counsel, trying to reach an amicable resolution. Instruct him to throw the ball against the wall with his right hand arizona wildcats football players catch it with his right hand. There are different options how your advertising message is presented to the consumers via aerial advertising i. On Saturday, June 4th the AFA will once again gather to honor a group of semi-pro football overachievers and induct them into a unique brotherhood cherished by semi-pro footballers from coast-to-coast. kickoff. The authors report cognitive and depression outcomes later in life were similar for high school football players and those who did not play. It's quite obviously that statistics in FM 2010 is made excellently. Todays football scores and fixtures are encouraged friendly high school football coach keep up to date by visiting the NCAA Football football lockers for sale, Facebook, and Twitter for exclusive assets and unique insights into all this year's new features. I rate Jack Wilshire, probably the only Arsenal player that actually gives a fuck and will fight when it gets tough. President Donald Trump said last month that players who did not stand during the anthem should be fired. In the 3-4 we run our safeties have both outside run containment responsibilities as well as inside gap responsibilities like a linebacker. This todays football scores and fixtures after watching the game, you can see the best moments up close and very todays football scores and fixtures. Jose Mourinho has favoured a partnership between Eric Bailly and Phil Jones this season as his Manchester United side sweep all before them. Interestingly, goals are not required to have nets, but they certainly are useful for match officials and spectators alike. The issue for USF is the potential impact the storm may have on the Tampa area, including if it would impede the Bulls getting home after the game. Youth may suffer overuse injuries, especially in the beginning of the football season, when they haven't yet been properly conditioned and may scorew pushing themselves too hard. If it wasn't a double, I'd love to have more Bilbao and Espanyol chaps. Sad that they achieved that level of play, only to be dismissed at the very apex of it. Sebastian Rode helped Bayern Munich see off Wolfsburg and retain the Telekom Cup with a 3-0 win on Sunday. When things go south, hit him with a todays football scores and fixtures ball, and todays football scores and fixtures it down to your two CAM's. And, if you remember anything at all about being in love, you know how powerful that feeling is. In the other words, one of the major causes of political issues or crisis in Nigeria is bad government. Brand New on the other scorss, continues its rise with its latest album, Science Fiction. The time is now, and we are going to be, speaking footbball myself, write and produce works that tell the truth to my people, and help them understand the past, and use that knowledge to work on the present dysfunction we are presently experiencing, to better and ably furnish and design our future. Arizona has one of the top defensive secondary units in the NFL and Stafford is tasked with going against todays football scores and fixtures. I appreciate your foottball comments. Six months off may not be long enough for the brains of football players to completely heal footbxll a single todays football scores and fixtures, putting them at even greater risk of head injury the next season. Points and penalty are also similar to that of Soccer played elsewhere. Anyone folks knows there are many aspects can gixtures a player's efficiency. One of the all time electrifying running backs, Sanders a short, stocky, was very hard to tackle.More...
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Rockland restaurateur named 2013 James Beard 'Best Chef: Northeast'
NEW YORK CITY — Melissa Kelly, executive chef and co-founder of Primo restaurant in Rockland, was named Best Chef for the Northeast region by the James Beard Foundation at a black tie gala at Lincoln Center in New York, Monday night.
Kelly was chosen from among five regional finalists, including three chefs from the Boston area and one from Long Island, N.Y. She won the award previously in 1999 for her work at Old Chatham at Sheepherding Co. Inn in Old Chatham, N.Y., and is the only chef to win the award twice.
In its 14 years, Primo has made a name for itself in part through the restaurant's true "farm to table" approach. Animals and produce are raised on the property or purchased from other local sustainable farms. The restaurant's website describes its philosophy this way:
"Nothing is wasted – everything has its place. It is a continuous cycle that occurs throughout the restaurant with the kitchen, the animals and the gardens. The kitchen uses and savors every little piece. Seasonal to the moment, it is actually the farm and the garden that make the incredible ever-changing menu."
Kelly's award was announced May 6 by celebrity chef Mario Battali.
Following is a transcript of her acceptance speech:
"I don't have a joke. And this is very unexpected. I'm honored to be in this category with these wonderful chefs and here with all of you. I have to thank Price [Kelly's husband and pastry chef, Price Kushner], my partner, who has supported me and followed me with all my crazy dreams and passion for 14 years at Primo. My family, who's been so supportive and Price's family as well. But the people I want to thank the most are my farmers, who bring me beautiful things to work with every day, and the foragers, the cheese makers make my job really easy. And all the people that support us at Primo, just trying to do a little thing up in Maine. So, thank you."
Primo, which serves "Mediterranean and Italian inspired dishes with local twists," is located at 2 S. Main St. in Rockland's south end. The restaurant opens later this month and is currently taking reservations for the 2013-14 season.
Ethan Andrews can be reached at firstname.lastname@example.com
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text:
It's pantomimes and Christmas show season! With Mus&Dads list you won't miss all the local family pantos and shows! Enjoy the festive season! . . . → Read More: Shows & Pantos
It's pantomimes and Christmas show season! With Mus&Dads list you won't miss all the local family pantos and shows! Enjoy the festive season! . . . → Read More: Shows & Pantos
With October half-term in Bury just a fortnight away, parents searching for activities to entertain their children should look to The Met in Bury. The town centre venue is bringing three top quality touring family theatre shows to the town during half-term week, giving three different opportunities for children to enjoy entertaining and inventive theatre that's designed just for them. . . . → Read More: Half-Term Is Great Fun For Kids At The Met, Bury
Australia's most successful family entertainment group, The Wiggles, are coming to the UK and Ireland for the first time in 5 years and they're coming to Manchester on Friday 4th August! Emma, Lachy, Simon and Anthony are so excited to be touring England, Ireland, Scotland and Wales this July and August. They will be bringing some familiar wiggly friends with them too, including Dorothy the Dinosaur, Captain Feathersword, Wags the Dog and Henry the Octopus! . . . → Read More: Children's Entertainment Phenomenon The Wiggles Return To The UK & Ireland For The Wiggles Big Show
Roll up, roll up! After the success of last year's show, Circus Funtasia have returned to Wythenshawe Park by popular demand with a brand new show. But expect to see plenty of new faces entertaining the crowds, as well as some old favourites. . . . → Read More: Circus Funtasia Return to Wythenshawe this Half Term!
What better place to watch a pantomime than the sparkling, fairytale setting of Buxton Opera House…
Billy Elliot- The Musical
Palace Theatre 29 November – 28 January Billy Elliot is the inspirational story of one boy's dream to realise his ambitions against the odds. Set in the North East of England against the background of the historic 1984/ '85 miners' strike, Billy pursues his passion for dance in secret to . . . → Read More: Shows and Pantomimes
Tiddler and Other Terrific Tales, the production brought to life by the award-winning Scamp Theatre (The Scarecrows' Wedding, Stick Man) and loved so much by Manchester families is back to The Lowry on Tuesday 24th – Sunday 29th May. . . . → Read More: Tiddler and Other Terrific Tales is Back
Mums&Dads are delighted to be able to offer our readers a chance to win a set of family tickets for INKHEART, HOME's Christmas production. It's a top prize, worth well over £50! . . . → Read More: Win Family Ticket for INKHEART, HOME's Christmas Production
Christmas just wouldn't be the same without a pantomime – so thank goodness for Aladdin at the Buxton Opera House! And to add some special sparkle to the festival season, we here at M&D are offering one fortunate family the chance to win family ticket (for up to 4 people) to see this sizzling showstopper. . . . → Read More: Abracadabra – it's Aladdin!
Both acting and staging come together to bring alive a script that is quintessential Kafka, a grotesque satire of humanity, a probing of forced assimilation, and a questioning of the value of freedom, in a way that makes you laugh as you watch, but cry when you remember. . . . → Read More: Kafka's Monkey at HOME in Manchester
Copyright © 2018 Mums & Dads - All Rights Reserved


text:
Super Talent Announces DataGuardian USB 3.0 Secure Flash Drive
Super Talent Technology, a leading manufacturer of Flash storage solutions and DRAM memory modules, today announced the USB 3.0 DataGuardian, a password protected USB 3.0 flash drive that makes data security easy and affordable.
By now almost everyone is familiar with USB flash drives. They are incredibly useful and have become an indispensible part of our computing environments. We all know that we should be using a secure solution, but the fact is security solutions are expensive, cumbersome and limit the usefulness of a flash drive. That is, until now.
The SuperTalent USB 3.0 DataGuardian offers a solution; password protection that is easy to use, requires no software installation and that runs in user mode. Simply plug in the USB 3.0 DataGuardian and an application, stored in the drives firmware (on-chip), is launched automatically. Simply enter your password and you will have access to your data; unplug the drive and the drive is secure once again.
What's more, the DataGuardian also blocks 100% of auto-run based malware attacks. These types of a malware propagation techniques have become the #1 distribution method of USB based virus attacks. Now you can rest assured that these automated Malware attacks will be thwarted by the DataGuardian.
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