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Betts' 2-Run Double Caps Red Sox 5-4 Comeback WinMookie Betts lined a two-run double off the left-field wall with two outs in the ninth inning, capping a three-run rally that lifted the Boston Red Sox to a 5-4 win over the St. Louis Cardinals on Wednesday night.
Red Sox Use Triple Play, 8-Run Inning To Down Cardinals 10-4The Boston Red Sox beat the St. Louis Cardinals 10-4 on Tuesday night.
Betts, Bradley Go Deep To Lift Red Sox Over Cardinals 6-3The Boston Red Sox beat the St. Louis Cardinals 6-3 on Tuesday night to take the opener of a two-game interleague series.
Injury Report: Cardinals Expected To Play Lindley At QB In NFC Wild Card Vs PanthersA knee injury to QB Drew Stanton continues to slow him down in practices, but head coach Brian Polian is hopeful to have his second-string quarterback available for the Panthers. The Cardinals are a battered squad in other positions as well.
Arizona Cardinals Look To Defy Super Bowl Odds Starting With Carolina PanthersDoes Arizona have enough in the tank to make a deep run and play in its second Super Bowl in franchise history? It looks sketchy at best, but this is why you play the games. Arizona has a tough road to travel to get to the Super Bowl, but it is pointless to worry about that for now. For now, it is all about beating Carolina.
9 Reactions To Dodgers-Cardinals Home Plate Umpire Dale ScottAside from a seemingly generous strike zone, Scott also appeared to clap when Yasiel Puig was struck out during the third inning.
12 Reasons To Love New Red Sox Pitcher Joe KellyJoe Kelly is a great fit for Boston, both on and off the field.
Cardinals Beat Red Sox 3-2The Cardinals won their third in a row and fourth in the last five. Boston has lost three in a row.
Gallo Goes There: What Makes A Great Sports Town?Is it because every team in the city is equally loved and supported, with sellouts stretching back decades, through good seasons and bad?
Gammons On T&R: 'One Of The Most Intense Postseasons I Can Remember'Hall of Fame Baseball writer Peter Gammons called in to Toucher and Rich Wednesday morning to preview Game 6, and discuss what has been a truly memorable postseason run for the Red Sox.
Daily Talker: What's Your Game Day Ritual?Superstition in sports is well-known and well chronicled. For the 2013 Boston Red Sox, it's the beard. With the Red Sox one win away from clinching their first World Series title at Fenway Park in 95 years, we want to know - what's your game day ritual?
Pedroia, Victorino Win Gold Glove AwardsRed Sox second baseman Dustin Pedroia and right fielder Shane Victorino have each received American League Rawlings Gold Glove Awards at their respective positions.


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CodePlexProject Hosting for Open Source Software
Seems like they are both perfectly useful functions, so why not try to integrate the PNG2World functionality into this tool? This tool seems to be updated a bit more, so maybe it should live here. Since the other one is a fork, porting the code
over would be relatively easy.
I'm trying to use this creation tool, along with Games::RolePlay::MapGen, to create mazes within Terraria, so I'm highly interested in getting some good development going with this.
PNG2World will never see the light of day in MoreTerra as it's a flawed idea in the first place.
Terraria worlds have three layers of things that can sit in a single square on the map and it's completely possible for all
three to be visible at the same time. This would be an area with a background wall, a table and it's underwater. As of right
now only one color can be posted a single pixel on the map. It currently favors water, then the table then the wall so where
water exists the other two would end up empty. And if the water is only a tiny bit on the square there is no way to tell from
a single pixel of color.
Also right now MoreTerra shows no difference between a Torch and a Chandelier in it's colors so there's no way to tell
which one it was supposed to be when recreating the world. Nor does an image save the information about things
such as what is found in chests, the last known time of day or how many enemies are left in that goblin invasion.
In order to fix this I would have to hide the data for all three layers in the picture. This would either mean the colors would
have to make no sense at all or I would have to draw four pixels per every tile, making the PNG much larger. While this would
work it would make editing an image to change your world much more complicated to the point where no one would want to
do it.
It would honestly be easier for me and the users to simply create a world editing program than it would be to try and implement
such a thing. So far someone has made one and while it might not be quite what I'd want to see in an editor it certainly beats
trying to turn a picture into a World file. The one I am talking about is Tedit from BinaryConstruct. Give this a shot and see if it
would work well for you.
The current 2.0 Terraria World Creator does at least has a 2nd wall image to provide a second layer, though I forgot that liquid adds a third layer to the mix. He also built Chest/NPC/Sign information as separate files. While it's a little messy
(and the interface seems to be a bit buggy), it does provide a medium to build a map in one place and convert the information into a *.wld file.
My challenge is that I'm writing a Perl module (or some expansions to existing Perl modules) to produce a PNG image and the other files, so that they can be used in TWC. However, TWC seems to be somewhat abandoned or at least not as well developed
as this app. I could make the leap to create pure *.wld files. The file format isn't that bad, but there are some complexities with what it required to make full objects work, such as the size of a door/tree/vine, what soil is required for which
plants, roots, and what is considered "important" for extra X/Y data. (Actually, you're keeping track of the latter in tileTypeDefs, so I may be okay there.) I may just have to bite the bullet and dive into the other half of TWC/WorldMapper.cs/AnalyseWorld
to figure out what needs to be adjusted before the *.wld file creation.
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subset: commoncrawl


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With ever-growing popularity, the makers of the 'How It Should Have Ended' videos are progressively establishing themselves as the creators of some of the funniest animated shorts spoofing popular movies. Their fanbase was anxious to see an installment parodying ' Star Trek Into Darkness, and finally the HISHE crew has delivered!
Check out the newest HISHE video, including the legendary "Old Spock" and some great animation:
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text:
13-16 June 2010: 7th ANQUE's INTERNATIONAL CONGRESS
May 25th, 2010 |
Brussels, 25 May 2010. Mr. Tom Vereijken, Chairman of the European Water Partnership, will give a plenary lecture on "The future of water: A European perspective" on the occasion of the 7th Anque's International Congress to be held in Oviedo, Spain, 13-16 June 2010.
One of the most important challenges of the XXI century is to ensure the sustainable integral management of water to achieve a balance between water demand and water availability. Europe has extensive knowledge and experience in developing solutions in the field of water; however the fragmented character of the European water sector strongly limits its potential. Therefore, the aim of this Congress is to create the appropriate environment for establishing a debate forum for the exchange of information and for a better collaboration and/or coordination between companies, administrations, public organizations, research institutes and universities. The aim is not to look back into the past, the goal is to understand the future needs by analyzing the past and solve the future problems understanding the good and bad experiences of the past. The final goal is to give solutions for today and to open new perspectives for the future. To achieve this challenge a multidisciplinary approach is needed. This congress will give the opportunity of being in contact with other engineers and researchers but also with economist, layers, journalists, politicians, etc.
The 7th International Congress is organized by the National Association of Chemists of Spain (ANQUE).
For registration, program details and more information, please visit: www.anque2010.org


text: Video News: United States Justin Bieber, John Travolta and Aishwarya Rai lead the arrivals for annual AIDS research event ROUGH CUT (NO REPORTER NARRATION) STORY: A star studded 21st amfAR Cinema Against AIDS gala was held on Thursday (May 22) at the Hotel du Cap in Antibes. The high profile event has a reputation as one of the most glamorous nights in the Cannes Film Festival calendar and attracts stars from across the arts, this year including singer Justin Bieber, Oscar-winning actress Marion Cotillard, Sharon Stone, Jessica Chastain, Aishwarya Rai, Paris Hilton, John Travolta and Kelly Preston, and Carla Bruni. Founded in 1985, amfAR is one of the world's leading non profit organizations dedicated to ending AIDS through research. The arrivals culminate in an auction which raises money for AIDS research. © DailyMotion - Friday, May 23, 2014


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Peter Csathy
Latest from Peter Csathy
Crunch Network
Ten predictions for digital media in 2018
In reaction to 2017's sobering and frequently shocking negative societal forces, many digital media companies will take things even further by infusing their offline efforts with social impact, an inspirational and motivational element that is already proven to be commercially smart. Read More
Crunch Network
Netflix should be afraid of Disney's OTT play
With a 1-2 gut punch of streaming video on demand services for Disney and ESPN content, Disney looked straight into Netflix's eyes and pronounced, "Game On!" So, how worried should Netflix and its investors be? In a word, "Very." Read More
Top 10 digital media predictions for 2017
It's that time of the season again. Here are my Top 10 predictions for digital media in 2017. Read More
Crunch Network
Is Netflix Disney's next big buy and is Reed Hastings its next CEO?
Disney and Netflix are logical dance partners. And, just as we saw with the 50/50 cash and stock financial engineering that enabled AT&T to buy Time Warner, ever-creative Disney undoubtedly has the talent to pull it off. Read More
Crunch Network
Whether it's Disney, Amazon, or Apple, someone's definitely going to buy Netflix
New rumors swirl in our Media 2.0 world about one massive potential tantalizing and game-changing deal – Disney buying behemoth SVOD service Netflix. That makes sense – and may happen – but Apple (or even Amazon) make even more sense. Each has the means (Disney's market cap is about 3X Netflix's, Apple's is a whopping 12X, and Amazon's is 8X). In… Read More
Crunch Network
Whatever happened to MCNs?
Remember MCNs? Those quaint multi-channel networks — aggregators of YouTube channels — that generally focused on a specific vertical audience? In the past year or so, something curious happened — companies shied away from the "MCN" moniker. Some did so violently, contending they were never MCNs in the first place. Here the five reasons this happened. Read More
Predictions On The Future Of Digital Media
It's pundit time — this time, digital media style. Last year I predicted challenges to YouTube's dominance in online video, a beginning of cord cutting and the unbundling of video services, and an explosion in short form video content. This year the media landscape will continue to shift as VR grows up and consolidation takes over. Read More
Crunch Network
Scorecard: 2015 Digital Media Predictions
Last year on TechCrunch I made eight predictions about digital media. This post compares those predictions to the reality that is digital media in 2015. Read More
The Future Of Digital Media In 2015
Editor's Note: Peter Csathy is the chief executive officer and an investor for the business accelerator and development firm Manatt Digital Media.The firm is an investor in DanceOn and advises Whistle Sports. 2014 proved to be a transformational year for content-driven digital media and investment (a new "golden age" of content I predicted for TechCrunch at the beginning… Read More


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DOS to Hold "Our Ocean" Conference
The U.S. Department of State will host the "Our Ocean" Conference - focused on sustainable fisheries, marine pollution, and ocean acidification - on June 16-17, 2014, in Washington, D.C.
Conference participants will include experts from around the world who will explain the state of the science on each issue, explore the challenges facing the oceans, and share the solutions that are being applied successfully. Secretary of State John Kerry has made ocean issues a top priority for the Department.
"This conference will build on what we've done already and it will be an important start to a much larger effort, because if we are going to pass on a livable ocean to the next generation, we need to act much more forcefully now," Kerry said. "Whether we're talking about trade, or climate or food sustainability, there can be no doubt that the ocean requires our protection and our collective action."
Invitees to the conference include government ministers, scientists, advocates, people whose livelihoods and well-being depend upon the oceans, and members of the international oceans community. The conference program will feature interactive elements to ensure participation by communities around the world.
Spanning three-quarters of the planet, the ocean is the most important shared resource. It connects people – physically, culturally and spiritually. It is a driving force in the global economy, pivotal to food security, human health and scientific advancement, and home to a vast ecosystem that regulates climate and weather. Protecting the ocean requires broad engagement from the global community to help ensure the long-term sustainability of the marine environment. It is imperative for the United States and countries around the world to work together to protect and sustain it, as no one person or one country can use it or protect it alone.
The conference goal will be to promote a healthier planet by creating a healthier ocean.


text:
|Contract #
|Period of
|Centers for
Medicaid and
Medicare Services
|Sergey Mikhaylenko,
|Sole subcontractor
to Koniag
As part of the CMS Recovery Audit Contractor Data Warehouse (RAC-DW) project, Arch manages and maintains routine operations of the current system, and provides help desk support and disaster preparedness planning. We have implemented and continue to monitor system controls on user activities/uploads to ensure data quality, completeness and adherence with all RAC program/Data Warehouse policies and procedures. An ongoing requirement exists for IT development and enhancement services, as needed.
Services include: The conversion of existing code, implementation of Section 508 standards, and subsequent ongoing enhancement of the existing RAC Data Warehouse application's functionality
Several key objectives to this project are: The performance of the user interface, accurate incorporation of user data needs and their systems, and migration to a data center.
1. IT Services for Biomedical Research or Healthcare;
4. Outsourcing;
5. IT Operations and Maintenance;
6. Integration Services;
7. Critical Infrastructure Protection and Information Assurance;
8. Digital Government;
9. Enterprise Resource Planning; and
10. Software Development
Size – NAICS 541512 Computer Systems Design Services: This U.S. industry comprises establishments primarily engaged in planning and designing computer systems that integrate computer hardware, software, and communication technologies. The hardware and software components of the system may be provided by this establishment or company as part of integrated services or may be provided by third parties or vendors. These establishments often install the system and train and support users of the system. For a small business contract over $10 million, this project represents adequate size standard for task orders under $27.5 million for CIO-SP3
Scope – On this project, Arch manages and maintains routine operations of the current system, performing basic system design, development, and engineering functions; executing other services include: converting legacy code from .NET and ColdFusion to Java; and implementing Section 508 standards. Arch participates in fully testing each release prior to delivery, including positive and negative unit, integration, system, and regression tests. Arch assists in supplying complete release documentation, including a list of changes, functional specifications, test cases/results, operational procedures and user guide updates. Arch works cooperatively with CMS and the Data Warehouse user community to analyze and implement new program requirements and enhancement requests. New features or enhancements are packaged into quarterly releases through a structured change management process.
Complexity – Arch's contributions to the RAC-DW program as sole subcontractor are especially relevant to its bid for CIO-SP3. On this contract, Arch performs 8 of the 10 task areas from the CIO-SP3 RFP. The project is complex because there are enhancements scheduled as business needs arise with emergency releases. Arch staff is involved with eight of service task areas.
Cure Notices or Show Cause Letters – There have been no Cure Notices or Show Cause letters, to date, on this project.
Results Achieved In The Completion Of Actual Contracts And Task Orders - Arch has successfully implemented a total of 15 major as well as numerous minor system enhancement releases. Likewise, Arch staff continually addresses ad-hoc data requests that arise in conjunction with the warehouse. Arch's Change Management work on RAC DW is also noteworthy insofar as a rigorous change tracking process is in place whereby Arch documents, prioritizes, and tracks all change requests received from CMS. Arch also continuously manages RAC-DW system security. The Enterprise Support Services provided include Agile Methodology and following the Expedited Life Cycle (XLC) framework, Technical Review Board presentations, Change Control Board participation, and all of the various reports required as part of contract management. Arch has performed the contract within budget, contractual terms, conditions and scope since the inception of the contract in 2014. Arch has successfully completed project tasks within the Firm Fixed Price (FFP) allocated budget for the contract. There are no cost over-runs on the project. Arch continues to deliver all requirements as per customer expectations and project schedule.
Good soundness is a result of good soundness care and lifestyle. How can medicaments hels up? It is easy for individuals to buy medicaments online. How it is possible? Many humanity already know about Zovirax that is used to fight infections caused by certain types of viruses. Typically, in people with frequent outbreaks, The medicine is used to help reduce the number of unpleasant symptoms. The remedy will not fight herpes, but it can lessen the symptoms of it. Absolutely most popular is Cialis. What about order generic viagra and ? Most likely every man knows at least some about . Sundry websites describe it as . Though erectile disfunction is more common in men over sixty, men of any age can develop erectile problems. Sexual soundness is an great part of a man's life, no matter his age etc. People must always ask sexual physic specialist for medical advice about Cialis. You must be very circumspective while planning to get drugs like Cialis.


text: David McKenna is a professor at the University of Minnesota in the Department of Laboratory Medicine and Pathology. He earned his BS in biology and philosophy at the University of Notre Dame and went on to earn his MD at the St. Louis University School of Medicine in 1997. He holds the American Red Cross Chair in Transfusion Medicine and is Director of the Division of Transfusion Medicine. He also serves as the Scientific and Medical Director of Molecular and Cellular Therapeutics (MCT), the University's cGMP facility, as well as Laboratory and Medical Director of the University of Minnesota Medical Center Clinical Cell Therapy Laboratory and the director of the fellowship program in Transfusion Medicine/Blood Banking. McKenna is an active AABB member, serving on the board of directors for four years and leading the AABB Cellular Therapy Section Coordinating Committee for several years. He was a key investigator in the NIH-sponsored Production Assistance for Cellular Therapies contract from 2003-2015.


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CodePlexProject Hosting for Open Source Software
I have been using this forum for silverlight charting controls. It been really wonderful. I have hit upon an issue now, our dial charts needs to show threshold values i.e higher and lower threshold in the same dial chart. I have tried all options and featurs
i know so far on the control and not been able to reproduce this effect. Is there any way i can show threshold values in codeplex silverlight dial chart? ...Thanks...
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text:
Our Need For Repentance
The message of John the Baptist, shown in Matthew 3:2, Mark 1:4, and Luke 3:3 is "repentance for the remission of sins". When Jesus began his ministry after fasting and temptation in the wilderness, his first message was "repent, for the kingdom of heaven is at hand". (Matthew 4:17, Mark 1:15) Jesus told the Pharisees that his reason for coming to this earth was to call sinners to repentance. (Matthew 9:13, Mark 2:17, Luke 5:32) As soon as the twelve disciples were selected and began their ministry while Jesus was still alive, we are told that they went out to preach repentance. (Mark 6:12). After the resurrection, on the day of Pentecost when the Holy Spirit descended and many were convicted in their heart, the first thing Peter told them to do was "repent, and be baptized" and this message was continually preached in the early church. (Acts 2:38, Acts 3:19, Acts 8:22, Acts 17:30, Acts 26:20) In Revelation, repentance was a major part of the messages to the seven churches. (Revelation 2:5, 2:16, 2:21, 3:3, 3:19)
Since repentance was the first message of John the Baptist, the first message of Jesus Christ, the first message of the disciples before the resurrection, a continuing theme after the resurrection, and the key to overcoming for the seven churches, you must conclude that it is of paramount importance. (Please don't get the idea that repentance is only a New Testament concept. The word repent and other forms of the word, such as repented, appear in the Old Testament about as often as in the New, and some of the uses in the New Testament are referring to Old Testament characters, such as Esau in Hebrews 12:17.)
That the need to repent is essential is also conveyed in 2 Corinthians 7:10, which says that "godly sorrow worketh repentance unto salvation not to be repented of". Strong's Concordance and Dictionary tells us that the Greek word translated "not to be repented of" at the end means irrevocable, so what this verse is saying is that repentance leads to irrevocable salvation. Is irrevocable salvation something you want to obtain? You now have the key: repentance.
Repentance is not merely saying you are sorry. "Repent" is defined in Webster's Dictionary as "to turn from sin and dedicate oneself to the amendment of one's life". It is turning away from repeating that behavior ever again, and dedicating yourself to living a life free of sin. While this may run contrary to some modern church teachings that, for example, focus on prosperity instead of character change, or falsely claim "once saved, always saved", Scripture is clear that repentance, or a similar concept, obedience, are mandatory, not optional, for salvation.
2 Peter 3:9 "The Lord is not slack concerning his promise, as some men count slackness; but is longsuffering to us-ward, not willing that any should perish, but that all should come to repentance." This would seem to imply that in the end there are two groups: those who repent, and those who will perish. From this day forward, you would be well served to incorporate Psalm 139:23-24 into your daily prayers. "Search me, O God, and know my heart: try me, and know my thoughts: and see if there be any wicked way in me, and lead me in the way everlasting." Ask God to reveal to you the areas of your life that need repentance, and make that your life's work.


text: >> There is one rather large difference between the 4kq and Quantum Syncro, >> that is the rear drivtrain. On the Audi, it's obvious the Quattro system. >> However, on the VW, the front half is 4kq, the rear is VW Syncro system. >> the only car in the US to ever recieve A2/A3 chassis all wheel drive >> system was the Quantum. >Bzzzt. The Quantum Syncro is exactly the same as the 4000 quattro >mechanically, including both the front and rear suspensions. Now, >the FWD Quantum is not the same as the FWD 4000 in the rear suspension, >though. Sorry to add fuel to the fire, but I saw a Quantum Synchro wagon in the junkyard a few weeks ago, and the rear suspension was NOT like the 4Kq. It looked to use a trailing arm rather than the subframe-with-control-arm suspension of the 4Kq. The rear *drivetrain*, however, did look to be the same quattro system as in the 4Kq. Oh, and the wagon had the cool "Synchro" lettering embedded into the rear window defroster, just like the 4Kq "quattro" lettering. I thought it was a very nice touch. :) Later, Eric '85 Coupe GT --- Eric J. Fluhr Email: firstname.lastname@example.com 630FP Logic/Circuit Design Phone: (512) 838-7589 IBM Microelectronics Div. Austin, TX


text:
LONDON: Senior MQM leader Saleem Shahzad predicted former President Gen. (retd) Pervaiz Musharraf may lead a new political alliance, Samaa reported.
Talking to Samaa in a telephonic conversation from London, the MQM representative Shahzad said that Musharraf may play a role in leading a new political alliance involving MQM.
Hinting at its creation, he further stated that people may see the evolution of a new alliance within a month or two.
He further revealed that the alliance will constitute Muttahida Qaumi Movement-Pakistan (MQM Pakistan), Mustafa Kamal's Pak Sar-zameen Party (PSP) and the Pakistan Muslim League, all coming together on a single platform.
Shahzad also expressed the wish to see the three parties working together for Pakistan, and specifically Karachi. –SAMAA
Story first published: 19th October 2016


text: Hi, I would like to get some help because I am in trouble with threads. I work on a Solaris 8.0 (64 bit) system. Python is compiled with Sun CC (Forte 6.1) compiler with threading support. A small program telnetting to a computer often dumps core it works fine with gcc. Thanks, Gabor Pataki import threading import telnetlib def TelnetToIpw01(): hostname = "my_hostname" username = "user_name" password = "password" tn = telnetlib.Telnet(hostname) tn.read_until("login: ") tn.write(username + '\n') tn.read_until("Password: ") tn.write(password + '\n') class MyThread(threading.Thread): def run(self): print "ThreadID", self.cnt, "started" TelnetToIpw01() print "ThreadID", self.cnt, "finished" for i in range(0,4): m = MyThread() m.cnt = i m.start()


text:
Morning at All Souls College, before the gates are opened and before the students awake, when mist settles over the cobblestone streets and the library windows glow.
Morning at All Souls College, before the gates are opened and before the students awake, when mist settles over the cobblestone streets and the library windows glow.
The interior perimeter of the Oxford Museum of Natural History is guarded by the stone effigies of various "men of Science", from Aristotle to Darwin. These pedestaled figures serve as charming company to the casual wanderer, and there is nothing I like so much about them as their hands – folded, gesticulating, or holding the tools of their art or the objects by which they are recognized (Newton, for instance, bears an apple in his palm). A brief tour:
One midwinter's day, four friends, warmed by a hearty meal and a good deal of old claret, set out over Port Meadow at twilight to wander the shadowy ruins of Godstow Nunnery, and return by the glimmering lights of a distant village, see over the still river.
"there is something of the Winter that is primal, mysterious and utterly irreplaceable, something both bleak and profoundly beautiful, something essential to this myth of ourselves, to the story of our humanity, as if we somehow need the darkness of the winter months to replenish our inner spirits as much as we need the light, energy and warmth of the summer…Winter, more than any other, was the season of the imagination, of transformed magical landscapes and the eerie silence of the snow." – Sting, from 'If on a Winter's Night…"
As part of my ongoing autumnal nostalgia, I've been dwelling in particularly vivid memories of Oxford libraries, and none more so than the Old Bodleian. I spent the better part of my Oxford time in the Upper Reading Room, looking out over the Radcliffe Camera while reflecting over The Exeter Book of Old English poems, or cloistered in a glowing corner of Duke Humphrey's writing about Sea Voyages in ancient literature. I remember piles of dusty volumes, and the way the blue Camera dome looked in every light. I remember watching mist roll over the Exeter College gardens and Radcliffe square, and the particular echo of footsteps up the lonely, turning stairway. I remember looking out over the library as the sky turned deep blue in evening and the windows glowed golden, gazing at the spires dusted in snow, and wandering beneath the vaults of the Divinity Schools. I remember the smell and texture of vellum, the feeling of drawing my coat close against the cold inside, the way the shadows gathered between book stacks as night fell early in winter, and how every corner seemed to hold some secret enchantment, and every moment within was transformed into the beautiful, mysterious realm of the fairy tale.
I spent the better part of one year down in Oxford's Special Collections room reading medieval medical manuscripts. Most of the herbals, lapidaries and bestiaries were simple household guides, dashed off with ongoing notes, marginalia and things crossed out. But every once in a while I came upon something truly spectacular—rare and richly illustrated manuscripts, carefully crafted and copied, and far from practical. All manner of fantastic flora and fauna brightly graced the velum pages. Amidst the poppies and yarrow were mandrakes and monsters, prowling beasts and imaginatively rendered plants. Nary a leech was seen.
With all the vibrant colours of spring around, I find myself turning back to these golden winter flowers and grasses. I saw these in the Oxford Botanical Gardens on a day not long before Christmas, when the ground was frosty and the gardens empty. There was a low winter sun in the sky, and the muted December palette seemed every bit as lovely as a verdant spring meadow. Just something to think about as you weave daisy chains in the sun this May Day (which you should be doing right now, by the way)…


text:
Sweet Fall Styles at Poa
Celebrate the season with versatile clothing and accessories that are made with love.
Tags: Style Advice,
New in from Paris and New Hours!
Beautiful new pieces are arriving from Paris for the fall! We are also open until 8pm Wednesday to Friday evenings!
Tags: Style Advice, Paris fashion in Toronto, cool Toronto boutiques, Toronto's best kept secrets, Spa and Boutique Toronto, best shopping in Toronto, ladies fashion boutiques Toronto
Look of the Day: Vegan Croco-Suede Four-Way Stretch Leggings
Textural differences make these leggings a true standout. Made with 4-way stretch vegan leather, this style will take you from downtown c...more
Tags: Style Advice, vegan suede leggings, best vegan leather ever, Toronto fashion leggings, faux suede, faux crocodile leggings, best leggings toronto, outfit of the day, style of the day, look of the day
Must Have Style: Vegan Leather Leggings in Burgundy/Berry
These richly-hued vegan leather leggings are luxurious enough to wear with heels on a night out, but are also soft and stretchy enough to co...more
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Poa's Must Have Looks: Equestrian Chic
We love evoking posh riding wear; pairing masculine and feminine in a subtly sexy way.
Tags: Style Advice, posh clothing Toronto, Fashion boutique downtown Toronto, fashion blazers Toronto, horse riding fashion, equestrian fashion, Paris clothing Toronto


text:
Denong Wang1*, Srinubabu Gedela2,3
1Stanfordy Tumory Glycomey Laboratory, Stanford University School of Medicine, Beckman Center, Rm B006, 279 Campus Drive, Stanford, CA 94305-5120, USA
2Center for Biotechnology & International Center for Bioinformatics, Andhra University College of Engineering, Visakhapatnam-530003, India
3Institute of Glycoproteomics & Systems Biology, Andhra Pradesh, India
Received Date: November 01, 2008; Accepted Date: November 04, 2008; Published Date: November 05, 2008
Citation: Denong W, Srinubabu G (2008) Insights of New tools in Glycomics Research. J Proteomics Bioinform 1: 374-378. doi: 10.4172/jpb.1000046
Copyright: © 2008 Denong W, Srinubabu G. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Journal of Proteomics & Bioinformatics
Since the origin of Journal of Proteomics & Bioinformatics the equivalence of papers published from different omics disciplines is steadfast. The present editorial describes the new tools in glycomics research.
-omics era
Completion of the genome sequencing projects not only provides insight into the complex origin, history and relatedness of the species, but also helps in understanding molecular pathology of genetic diseases. Unrevealing of the repertoire of genes in an organism opens the door to the universe of Proteomics and Glycomics diversities and to the new levels of understanding of the complexity of living species.
The "omics" are usually named based on its main molecular target, such as Genomics for the Genomes, Proteomics for the Proteomes, and Glycomics targets the universe of sugar chains and carbohydrate-containing macromolecules. There is, however, no boundary among "omics" in exploring the mysteries of lives. Instead, there is increasing need of integrated studies of living organisms. Systems Biology & Medicine emerged to accommodate with these new developments.
Glycomics is Complementary to Other –omics
Carbohydrates are prominently displayed on the surfaces of cells and present in many secretory proteins in bodily fluids. Expression of complex carbohydrates by human cells are characteristically associated with the stages or steps of embryonic development, cell differentiation, as well as transformation of normal cells to abnormally differentiated tumor cells. Sugar moieties are also abundantly expressed on the outer surfaces of the majority of viral, bacterial, protozoan and fungal pathogens. Many sugar structures are pathogen-specific, which makes them important molecular targets for pathogen recognition, diagnosis of infectious diseases, and vaccine development.
Altered glycosylations are associated with many human diseases. Structural and functional changes of glycans may thus serve as biomarkers of tumors, some type of cancers, peripheral vascular diseases, coronary artery diseases, inflammation, diabetes mellitus and associated complications (microvascular-nephropathy, retinopathy and neuropathy; macrovascular-stroke, cardiomyopathy and stroke). Augmented acquaintances on disease associated alterations in glycosylation tessellations and its data integration with proteome, genome and transcriptome endows new intrinsic biomedical insights and thus, far-reaching peradventures diagnostic application (preventions, early stage identification and cure) as well as for the new therapeutic discovery.
Identification of glycan markers for pathological conditions is, thus, one of the major jaunts for glycomics research. To let this area of postgenomics research with focus on new tools and technologies, scientists and scholars must be attracted, and they should be trained in this highly bustling area of research that crosses the barriers between various disciplines.
Emerging High-throughput Glycomics Tools
Biophysical, biochemical and classical immunological methods have proven very valuable in studying carbohydrate- carbohydrate and carbohydrate-protein interactions. They were, however, designed to monitor carbohydratebased molecular recognition on a one-by-one basis and have limited analytical power or throughput in practical applications. In the past few years, a number of experimental approaches have been developed to fill this gap. Glycans profiling and sequencing with MALDI-MS, MALDI-FTMS, CID MS/MS and MALDI-TOF-MS are developed for high throughput structural characterization of glycomes. Advances in the development of microarray-based approaches are poised to accelerate progress towards better understanding of the roles of carbohydrates in biology and medicine. Carbohydrate microarrays, lectin & antibody arrays, neoglycolipid (NGL) technology coupled with mass spectrometry for carbohydrate ligand discovery, fluorescent neoglycoconjugate probes, and aminoglycoside antibiotic microarrays are among the many new tools becoming available to glycobiologists.
In spite of their technological differences, the microarraybased technologies are all solid phase binding assays for carbohydrates and their interaction with other biological molecules. They share a number of common characteristics and technical advantages. First, they contain the capacity to display a large panel of carbohydrates in a limited chip space. Second, each carbohydrate is spotted in an amount that is much smaller than that required for a conventional molecular or immunological assay. Thus, the bioarray platform makes effective use of carbohydrate substances. Third, they have high detection sensitivity. The microarray-based assays have higher detection sensitivity than most conventional molecular and immunological assays. This characteristic is attributed to the fact that the binding of a molecule in a solution phase to an immobilized micro-spot of ligand in the solid phase has minimal reduction of the molar concentration of the molecule in solution. Therefore, in a microarray assay, it is much easier to have binding equilibrium take place and result is high sensitivity. Different platforms of microarrays are technically complementary and helpful for addressing many of problems in the glycomics research.
Consortium for Functional Glycomics
The Consortium for Functional Glycomics (CFG) has taken solid steps in facilitating key areas of glycomics research. One of the goals of CFG is to define paradigms by which glycan binding proteins mediate cell communication. Data towards achieving this goal is compiled in the CFG database, which can be accessed at<www.funtionalglycomics.org>. Among the resources as services offered by the CFG to its investigators are glycan analysis, glyco-gene microarray, mouse knockout strains, mouse phenotype analysis, carbohydrate compounds, and glycan microarrays for screening the specificity of glycan binding proteins, including recent development of CFG pathogen carbohydrate arrays. A challenging issue is to select and obtain glycans of highest priority to the community since over 8800 structures are reported in the Bacterial Carbohydrate Structure Database (www.glyco.ac.ru/bcsdb/start.shtml).
Analogous to CFG in US, there is emerging of consortiums of glycobiologists in various countries worldwide: (http://www.functionalglycomics.org/static/consortium/links2Website.shtml)
Tumor Glycome Laboratories of the NIH Alliance of Glycobiologists for Detection of Cancer and Cancer Risk
Numerous studies comparing normal and tumor cells have shown that changes in glycan structures on the cell correlate with cancer development. Compared to molecular proteins, molecular glycans are extremely abundant and recent advances in technology have now allowed the effective systematic study of these structures. In late 2007, the National Cancer Institute launched a new initiative to discover, develop, and clinically validate cancer biomarkers based on complex carbohydrate structures attached to proteins and lipids. (http://prevention.cancer.gov/programs-resources/ groups/cb/programs/glycome).
Seven Tumor Glycome Laboratories have been funded to search for glycan-based biomarkers for breast, ovarian, lung, prostate, and pancreatic cancers and melanoma. NCI's Tumor Glycome Laboratories are the principal component of the new trans-NIH Alliance of Glycobiologists for Detection of Cancer and cancer Risk. The other members of the Alliance are the Consortium for Functional Glycomics supported by the National Institute of General Medical Sciences
and the Glycomics and Glycotechnology Resource Centers supported by the National Center for Research Resources.
Integrating Data
The challenge for -omics is to tackle the problem of fragmentation of knowledge by integrating the many sources of heterogeneous information into a systematic entity. It is widely recognized that successful data integration is one of the keys to improve productivity for stored data. Through proper data annotation tools and algorithms, researchers may correlate relationships that enable them to make better and faster decisions about new inventions. The need for data integration is essential for present glycomics community, because glycomics data is currently spread across geographically in wide variety of formats. These formats can be integrated and migrated across platforms through different techniques. One of the important and widely usable, easily understandable techniques is the XML.
Extensible Markup Language
Today, there is an augmented requirement in different omics fields to combine available software tools into chains, thus building multifarious applications from existing singletask tools. To create such workflows, the tools involved have to be able to work with each other's data therefore, a common set of well-defined data formats is needed. Opportunities for new ways of combining and re-using data are arising as a result of the increasing use of web protocols to transmit structured data where Extensible Markup Language (XML) is coming into the picture; The XML is a general-purpose markup language helps in sharing, migrating data across heterogeneous systems and storing information, this facilitates data integration and application through the adoption of standards for representing certain types of data, e.g., genome, proteome, glycome, metabolome annotations. XML is designed to provide a document markup language that is easier to learn, pain less retrieve, comfortable to store, effort less transmit, and semantically richer than HTML. It provides a common format for expressing both data structures and contents making it a standard for data representation and transformation. Hence, it can help in integrating structured, semi structured, and unstructured data over the web repositories.
Computational Biology and Informatics Laboratory at the University of Pennsylvania came forward for managing and analyzing genome sequences using Extensible Markup Language Genomics Unified Schema (XMLGUS). XMLGUS facilitates amalgamating data into GUS by (i) formulating an XML interface that includes relational database key constraint definitions, (ii) regularizing traversal through that XML, (iii) realizing automatic processing of the XML with database key constraints and (iv) allowing for special processing of input data within the framework for spontaneous processing. Web data such as nucleotide and protein sequences are retrieved by agent programs, stored in the extensible markup language (XML) files, then parsed and loaded into the secondary database, and transformed into the hyper text markup language (HTML) files for publishing. Once a standard is agreed upon, all databases and applications that store or process the data can share a common interface. It has major advantages are its ease of use, wide support available from software, database and LIMS (Laboratory Information Management System) vendors, and the large number of tools that exist to facilitate its use. A steadily growing number of databases, software applications and tools are XML-compliant, such as NCBI BLAST, DOAJ, PIR, SWISS-PROT, InterPro etc.
Database Federation
A federated database is a logical association of independent databases that provides a single, integrated, coherent view of all resources in the federation. It is one approach to data integration in which middleware, consisting of a relational database management system, provides uniform access to a number of heterogeneous data sources. Developments in our ability to integrate and analyze data held in existing heterogeneous data resources can lead to an increase in our understanding of biological function at all levels. However, supporting ad hoc queries across multiple data resources and correlating data retrieved from these is much more complex. To handle this conditions mediator like P/ FDM helps, which integrates access to heterogeneous distributed biological databases. Our architecture makes use of the existing search capabilities and indexes of the underlying databases, without infringing on their autonomy. This technique leverages the native data management and search capabilities of individual source databases and creates a single, unified, logical view of the federated databases. Two major problems in constructing data federations (for example, data warehouses and database federations) concern achieving and maintaining consistency and a uniform representation of the data on the global level of the federation. The first step in creating uniform representations of data is known as data extraction, whereas data reconciliation is concerned with resolving data inconsistencies. In a proxy cache for federations of scientific databases it is important to estimate the size of a query before making a caching decision. With accurate estimates, near-optimal cache performance can be obtained.
Even though the most common means of data integration can be done with programming model, such as CORBA(Common Object Request Broker Architecture), J2EE (Java 2 Platform, Enterprise Edition), that access sources of interest directly and combine the data retrieved from those sources with the application itself. This approach always works, but it is expensive. Database federation is cost effective and it does not require modification of the primary data stores as most are large number of heterogeneous databases to deal with. Furthermore, many databases (i.e., PDB) are in the public domain and thus not directly modifiable by researchers.
Controlled Vocabularies
Controlled vocabularies are integrating heterogeneous glycomics data sources are based on one of a common field, ontology or cross-reference. In a glycomics context, controlled vocabularies offer a form of data integration by enforcing naming conventions for data elements that ultimately appear in glycomics databases.
Statements and Recommendations
New Tools and Technologies
A number of high-throughput glycomics tools have reached or are very close to the stage of the current nucleic acidbased microarrays that are readily available for practical uses. Technical issues that require immediate attention may include but are not limited to optimization of existing technologies for array construction, quality control and technical standardization in both microarray production and application, establishment of specialized bioinformatic tools to handle the massive amount of carbohydrate microarray data and to effectively extract diagnostic or research information from each microarray assay.
Exploring the repertoires of glyco-epitopes and their receptors represents a long-term goal of carbohydrate research. How big is the repertoire of glyco-epitopes? Addressing this question is one of the most important topics in the post-genomics era. It was estimated that there are about 500 endogenous glyco-epitopes in mammals. However, this estimation did not consider the repertoires of the "hybrid" structures that are generated by protein posttranslational modification, including both N- and O-glycosylation. Further more, the conformational diversity of carbohydrates and micro-heterogeneity of carbohydrate chains substantially increases the repertoire of carbohydrate-based antigenic determinants or glyco-epitopes. Considering carbohydrate structures of the microbial world, which are directly relevant to medicine, the sizes and diversity of the repertoires of glyco-epitopes are unpredictable. Establishment of high-throughput platforms of carbohydrate microarrays provides powerful means to facilitate the identification and characterization of carbohydrate-based pathogen signatures and other biomarkers.
Joint effort by academic and industrial sectors is highly recommended to direct the establishment of libraries of monoclonal antibodies, lectins and other carbohydrate-binding proteins. These biomolecules are critical for defining glyco-epitopes and are useful for detection of glyco-epitopes in living organisms. Thus, using specific immunological probes to characterize glyco-epitopes is equally important to the structural determination of glyco-epitopes. Similar effort has been successfully made for protein-based biomarkers. A notable example is the establishment of a large collection of monoclonal antibodies for cell differentiation antigens (CD antigens). Availability of specific probes for CD antigens, in combination with the state-of-art technologies of flow cytometry (Hi-D FACS), has revolutionized research in cellular biology and immunology and medical applications of CD antigens, especially in the clinical diagnosis of leukemia and other human diseases. Exploring the repertoires of glyco-epitopes and their cellular receptors, with the aid of new Glycomics tools and specific immunological probes, represents one of the highly active areas of postgenomics research that may last for a few decades and likely accompanied with a fruitful outcome.
Mass Spectrometry and Its Prone
Mass spectrometry (MS) is appearing as an empowering technology in different fields. Coupling capillary electrophoresis, hydrophilic interaction chromatography and other advanced miniaturized separation techniques with this emerging technology-is the hub of present proteomics, metablomics and glycomics research.
Protein glycosylation play crucial roles in preservation of the function of a glycoprotein. Therefore, prominent streamlined sample preparation protocols are prerequisite in preparation of a biological active protein product, including protein- based drugs. Glycans profiling and sequencing with MALDI-MS, MALDI-FTMS, CID MS/MS and MALDITOF- MS are the most impressive approaches for high throughput glycomics applications. During the experimentation, the production of vast amount of glycomics MS data is a large-dimensional optimization problem. Threshold gradient descent regularization algorithms, numerical simulation studies, systematic representation of glycan structure may be suitable for theoretical generation of all possible first and second generation fragments resulting from glycosidic and cross ring cleavages. Despite the wealth of data provided by the most overwhelming MS and MS/MS techniques, most of them are not reproducible. There is a need to develop suitable validation parameters to get robust results.
Mathematical Modeling-Inter Disciplinary Approach
The increasing use of mathematical modeling in –omics research is inevitable as biology becomes more quantitative. The complexity of the biological sciences assembles inter disciplinary involvement requisite. For the software engineer, biology opens up new and exciting branches while for the biologist, mathematical modeling offers another research appliance launches with a new powerful laboratory technique but only if used appropriately and its limitations identified.
Few models, N-Glycosylation, galactosylation of an oligosaccharide are mathematically formulated. There is a requirement to develop new model identifies the substrate specificities of known glycoprotein. These models are additionally extended to encompass enzyme kinetics, biomarker prediction, structure annotation and sequence analysis using nonlinear algebra. However, the use of esoteric mathematics arrogantly applied to biological problems by software engineers who know little about real biology, together with unsubstantiated claims as to how important such theories are, also little to promote the interdisciplinary involvement which is so essential.
Databases and Required Improvements
The challenge for present glycomics community is to develop existing and upcoming information accessible from beginning to end in one master database system. Today, however, GlycomeDB database available with the linking of the glycan data in the seven major databases such as Bacterial carbohydrate structure database (BCSDB), Complex carbohydrate structure database (CCSD), consortium for functional glycomics (CFG), Glyco Base(Lille), Kyoto encyclopedia of genes and genomes (KEGG). However, it will be useful to provide integrated data (preferably XML format) instead of linking. This database should contain 1) a single glycan structure that collide with well circumscribe reliance standard, 2) The earliest known data for the structure, combining literature reference, an account of its biological origin, and its analytical information used in its project. The master system has to collide with the intrinsic complexity of glycomics research and open up the information (preferably open access) for the scientific community. Additionally, the new database should be cross connected with genomics, proteomics, metablomics, protein structure databases, and it should have robust annotation tools.


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When we fly the S800 we fly it as a two-person job. One pilots the multi-rotor while the other person works the camera control (Zenmuse gimbal, not only keeping the footage steady, but lets you rotate 360 degrees and tilt up and down). We both use a monitor; the person on the camera controls uses a live-video feed from the camera to align the shot, the pilot uses a ground-station.
The Ground Station software has two instrument panel options as well as its primary display of the aircraft location superimposed on top of a Google Earth background. It is a very valuable tool. And here is why.
Yes, you can still see and orient the position of the flying machine by looking up in the sky. However, it is not always easy to figure out its true orientation. Also, if you are 500 feet away, it starts to get more and more difficult to make out the front and the back.
As you can also see, the background is a map of the location as seen from above (Google Earth). This helps the pilot to orient him or herself. In addition there are additional instrument panels on the screen providing further flight telemetry data, which is essential to safe and successful flying.
I quickly moved over to the ground station and started calling out telemetry information to Mark. Doing that gave Mark, who was piloting the S800, a quick overview of the current situation on the orientation of its aircraft. The multi-rotor was far enough away that it was impossible for Mark to accurately determine the craft's heading. By watching the ground station screen I was able to instruct Mark to yaw left or right and thereby keep the heading
Once we both got situational awareness back, I started lining up the shots by zooming in on the ground station, getting a close look at the Boardwalk and directing Mark with simple commands. By not working the camera control, the camera is now only pointing forward. So the subject you want to film has to be always in front of the multi-rotor.
To make things easier, Mark and I use directional commands as they apply to the transmitter stick-inputs. "Yaw right" always means moving the left (rudder) yaw stick to the right, "Slightly moving left" always means using the right stick (aileron) to the left.
Here is a short clip demonstrating how precise one can fly via only the ground station and by working as a tight-knitten team.


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Welcome Sara_B!!!
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December 12th, 2006, 01:09 PM
Platinum Supermommy
Join Date: Aug 2006
Location: Pittsburgh PA
Posts: 10,350
Yep, and here we are... Thanks for the welcome! I've been reading up on statistics and what not and it's really driven home that the unplanned C-section rate is going up the more managed delivery becomes. It's hard to believe that doctors KNOW these stats and still don't change the way they view labor and delivery. If they wanted a set schedule why did they become doctors, let alone obstetricians? sheesh!
Sara, 27, married to Shane, 31, mom to Gemma, 6, and Ashlyn, born 8/7/10
Running for my health and sanity!
PR's: 5k-25:05 (old PR 25:10), 5M-45:03 (old PR - 47:22), 10k - 52:00 (approximate - training), HM-2:25:58 (ran a 2:17:36 during marathon), Full- 4:49:25 (old PR -5:49:40), 50k-7:05:56, 50M-13:31:14, 100k- 18:59:31 (old PR 20:56)
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Summary from Goodreads:
If you've been feeling neglected by the Goddess of Love lately, don't worry — Hannah Maquiling, college sophomore, is in training to take over. The Original Goddess is missing, but Hannah is Interim Goddess now, and she should figure out how to solve humanity's love problems soon. Quin (God of the Sun) is still her mentor, still really hot, but apparently isn't as honest about his other earthly relationships as she thought. It's frustrating, and enough to make her check out possibilities with Diego (God of the Sea) and Robbie (Cute Human).
In the meantime, she's decided to spend some of her precious training time helping to break up a relationship, instead of putting one together. Why? Because the girl in question happens to be her best friend Sol, whose boyfriend is stealing not just from her, but from other people on campus. Sol didn't exactly summon the Goddess, but this is what power over Love is for, right? Surely it's not just about matchmaking, but ending doomed relationships too. (Even when it's not what people want.)
Queen of the Clueless is the sequel to the Interim Goddess of Love which I read a few months back. I had a little bit of a hard time getting into the world of Hannah and Quin as gods in the first book, but in this second installment, I feel that I am slowly adapting into the mythical world Mina V. Esguerra has created. I still like the touch of Filipino mythology and I find Hannah more likeable this time. She is finally working on her powers as the Interim Goddess of Love and she is learning more about her own self — and this includes sorting her feelings towards Quin.
As in the first book, I am still more fond of Diego as opposed to Quin. Despite Diego's brusqueness, I still find him appealing although I must admit that Quin has this air of mystery surrounding his character. I love it that Diego has more exposure here than in the first book. Hee. 😉 To tell the truth, I really don't care that much about Quin. I don't know, maybe I just feel that since he's the god of the Sun and all, he must be unreachable to a mere mortal like Hannah. Hence, they are not — could not be — a match for each other. But then again, this is fiction, right? Ah, but I love it that Ms. Esguerra has kept me guessing as to who Hannah will finally end up with. 🙂
The story of Sol and her boyfriend adds excitement to the book as well, and the mystery of an unknown supernatural being roaming the halls of Ford River has kept me turning the pages until I reached the end. And then there's Robbie, the human. He's a likeable character and I sometimes find myself rooting for him as well. Maybe Hannah is better off with him than pining for a supernatural being?
Queen of the Clueless provides just the right amount of excitement for me to get on to the finale. I can't wait to read the last installment, Icon of the Indecisive, which is already available in Amazon. I want to find out who Hannah finally ends up with, or if she will finally end up with someone. I also want to know if she gets to be Goddess of Love permanently. And of course, I'd love to see more of Diego. Hihi. 🙂
3/5 stars.
My copy: ebook, a gift from Mina V. Esguerra herself. Yay! 🙂


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Local train derailment: Quick thinking by motormen avoided head-on collision
Operators of the derailed local and the train coming from the opposite end took steps and averted a major tragedy
A potential disaster was avoided on Thursday, thanks to some wise moves by the motormen of both the Up and Down trains, when the former the Kasara-CST local derailed near Titwala around 2.50 pm.
S K Mishra (left) alerted M D Kulkarni (right), motorman of the Thane-Kasara train, with flashlights
S K Mishra was driving the train that derailed, while M D Kulkarni was in-charge of the train coming from the opposite end, a Kasara-bound local train from Thane.
Eyewitnesses at the accident site said things would've been much worse, had Mishra not alerted the driver of the train coming in from the opposite end. Mishra got down from his cabin as soon as his train derailed, and alerted Kulkarni with flashlights and red flags.
"Both the trains would have collided and there would have been many more in the dead and injured list. The motorman tried to control and save passengers at his level best," said Sulabh Kumar, who was in the Thane-Kasara train.
Kulkarni says this was his first such experience in his 12 years of service, although he has been with Indian Railway for the last 23 years. "It would have been like the Vidarbha train collision near Kasara in 2012," added Kulkarni.
Still in hospital
Mishra's blood pressure shot up after the incident and he had to be admitted to the ICU of Kalyan Railway Hospital. He has now been shifted to the general ward. However, the guard of the train, R N Dubey, is still in the ICU of Fortis Hospital in Mulund with head injuries.
Railway authorities are planning to reward both the motormen, for applying their minds and saving lives. Atul Rane, chief PRO, Central Railway, said, "They have done a good job and tried to save hundreds of passengers lives. We are hoping for their quick recovery."
Vidarbha Express mishap at Kasara
On July 19, 2012, the Mumbai-Gondia Vidarbha Express collided with a Kasara-CST local that had derailed between Kasara and Umbermali around 9.30 pm. Six coaches of the local train had jumped the tracks due to a landslide around 9.30 pm.
The Express train had left CST at 7.15 pm and was speeding towards Kasara, rammed into the derailed coaches. The engine driver of the train tried avoiding the derailed bogies and applied the brakes suddenly, which caused the engine and three bogies to go off the tracks. Two people were killed and 71 were injured in the incident.
>> S K Mishra was driving the derailed local train
>> M D Kulkarni was at the wheel of the train coming from the opposite end
>> Mishra alerted Kulkarni with flashlights and red flags


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What is this 'hackerspace' of which you speak?
Before we go any further... A hackerspace is not a place where a bunch of bad people sit around trying to tap into your computer. A hackerspace is all about open-access and collaboration for creativity and innovation.
'A hackerspace or hackspace (also referred to as a hacklab, makerspace or creative space) is a location where people with common interests, often in computers, technology, science, or digital or electronic art (but also in many other realms) can meet, socialiseand/or collaborate. Hackerspaces can be viewed as open community labs incorporating elements of machine shops, workshops and/orstudios where hackers can come together to share resources and knowledge to build and make things.'
A hackerspace is about making things, hacking (or making things do stuff it wasn't originally purposed for), discovering, collaborating and having fun.
Is there room for soil science in a hackerspace?
Soil science is about innovation and interdisciplinary thinking.
If soil science fits the philosophy of a hackerspace, is there anyone 'hacking' soil?
After the 2011 Japan Tsunami and Fukushima Disaster, the Tokyo Hackerspace got involved in monitoring the radiation of affected soil. This included assembling community geiger counters for hour by hour safety checks. They used technical skills and collaboration to not only get data on soil radiation in Japan, but also come up with some nifty ways of doing it too. Hello bGeigie!
For the Great Global Hackerspaces Challenge 2011, the Maui Makers made a Chilled Soil Agriculture demonstration/box. Cold water is pumped through soil to emulate seasons, and thus allow growth of temperate species in tropical areas. This really is something I have never heard of and is well awesome!
Noisebridge is getting involved with UC Berkley on a Deep Roots Irrigation Precipitation System (aka DRIPS):
And Quelab seems to be doing all-things-soil too! Amongst many other hackerspaces as well...
And what about my contribution to soil science in hackerspaces?
A friend of mine posted to me a DIY Mini Terrarium. I am totally going to give it a go. Then maybe think about some other pet projects of mine. Such as simpler, more people-friendly and cost effective methods for analysing soil. I can see an Arduino being involved there... Or maybe a soil science wiki...
And getting more people involved. Work with others in the space and community members. Drawing on different skills, backgrounds and ideas you never know what may be achieved!
After? Well the sky is the limit!
Keen on soil hacking? Find your local Hackerspace on Hackerspaces.org
Congratulations to Make, Hack, Void (a Canberra Hackerspace) on their one year anniversary! May there be many more years of making stuff, hacking things to get them to do rad stuff, and voiding warranties. And if you are in Canberra at any time, please look us up.


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Film advertisement created by Fred & Farid, France for Orangina, within the category: Non-Alcoholic Drinks.
Creative Directors: Fred & Farid
Concept: Frederic Raillard, Farid Mokart
Art Directors: Frederic Raillard, Farid Mokart, Pauline de Montferrand
TV production: Emmanuelle Grenier
Post production: Katharina Nicol
Realizer: Joseph Kahn
Production: HSI
Producteur: Kil Dellara
Musique: Gum / Green United Music
Post-production: Eight VFX Los Angeles
I like it.
But there might be something I'm not getting...
Wouldn't it be better for only the woman to be drinking the Orangina? And for her to take it with her when she leaves the cafe? For the Orangina to associate with her personality?
I suppose a reply to that could be that you don't want to only target women with the product. But that could be handled in other ways. And it seems to me it would be a much stronger ad if you associate the Orangina with her personality.
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More and more clients are asking us for Speakers who can show their Leaders how to engage, inspire, encourage, and develop their employees and teams. Here are our 12 highest rated Speakers on Leadership.
Mike Abrashoff on It's Your Ship http://thesweeneyagency.com/speakers/Mike-Abrashoff
Ty Bennett on Partnership is the New Leadership http://thesweeneyagency.com/speakers/Ty-Bennett
Polly Labarre on The End of Leadership http://thesweeneyagency.com/speakers/Polly-LaBarre
Mark Crowley on The Heart of Great Leadership http://thesweeneyagency.com/speakers/Mark-C.-Crowley
Chester Elton on Leading a Culture of Belief http://thesweeneyagency.com/speakers/Chester-Elton
Tasha Eurich on Bankable Leadership http://thesweeneyagency.com/speakers/Dr.-Tasha-Eurich
Mark Thompson on The Most Admired Leaders http://thesweeneyagency.com/speakers/Mark-Thompson
Dr. Nicole Lipkin on Leading to Engage http://thesweeneyagency.com/speakers/Dr.-Nicole-Lipkin
Scott Snook on Authentic Leadership http://thesweeneyagency.com/speakers/Scott-A.-Snook
Libby Gill on Igniting Bold Leadership http://thesweeneyagency.com/speakers/Libby-Gill
Patrick Lencioni on The Advantage http://thesweeneyagency.com/speakers/Patrick-Lencioni
Carol Kinsey Goman on the Language of Leaders http://thesweeneyagency.com/speakers/Carol-Kinsey-Goman


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Confession of a shopoholic. I may or may not have an album on my phone where I save any looks I see on instagram in a separate folder- whether I like the whole outfit, a single piece, or the photo itself- it has it's own designated corner in my phone. (Kind of like pinterest, but they're all pulled from Insta.) Does anyone else save "looks they love"?
About a month ago I happened to save this look from Express, swooning over the coat.
This Sherpa wedge jacket is now on sale for 50% off! I happened to be shopping the after holiday sales last week and ran across one and nearly pooped my pants. You know I had to have it! It's relatively light weight so I can either layer with it or I'll be able to wear it without sweating my ass off in the early spring months. An excellent choice!
Lately, I've been super into neutrals. Neutral everything. Black, white, grey, nudes, creams and whites. Everything. Plain and simple. What are your end of winter obsessions?
OOTD details below.
//Express: Sherpa Wedge Jacket (On Sale for 50% off)// HM: Skinny High Ankle Ripped Jeans// Pumps-Steve Madden: Proto Leather Pumps//Gloves: Target, Leather and Suede, Black and Ivory Gloves//Turtleneck: Forever 21, Contemporary Stretch Knit Turtleneck//Sunglasses: Zaful (Similar)//


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Community Satisfaction
In October 2013 Byron Shire Council sought to examine community attitudes and perceptions towards current and future services and facilities provided by Council. Key objectives of the research included:
- To assess and establish the community's priorities and satisfaction in relation to Council activities, services and facilities
- To identify the community's overall level of satisfaction with Council's performance
To facilitate this, Micromex Research was contracted to develop a survey template that enabled Council to effectively analyse attitudes and trends within the community.
The 2013 Survey was compared against the 2007 Survey. Key finding included:
Overall satisfaction with Council was 'moderate', with 72% of residents stating they were at least 'somewhat satisfied'.


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Many of you who have been around since the floppy disk days would have seen loads of floppy disks becoming unusable for storage of data. Like the old CDs these days, the old unused floppy disks used to create a lot of junks. If you still have those floppy, here are cool ways to use some useful stuff using old unused floppy disks.
Recommended Reading:
This post has a collection of how you can use your floppy disks in interesting ways. All the creative ideas are via instructables.com
1. Floppy Ceiling Lamp
You can create a nice looking ceiling lamp using floppy. Here Floppy discs were used to update an old ceiling lamp.
More info here.
2. Floppy Disk Notebook
Create some nice Floppy Disk Notebooks using some pretty simple instructions.
More info here.
3. Floppy Disk Bill Caddy
Conveniently build a caddy to hold all bill paying supplies and unpaid bills.
More info here.
4. Earrings made from floppy disk parts!
Make some cute looking metal earrings in five-minutes.
More info here.
5. Floppy Disks into Bracelets, Necklaces, or Belts
Easy to make floppy disk jewelries!
More info here.
6. Floppy Disk Laptop Desk/Stand
Here is a Laptop desk made from 82 floppy disks.
More info here.
7. Floppy Disk Pen Holder
This is very simple and most of you would have already tried.
More info here.
8. Floppy Disk Bird Feeder
Create a bird feeder with old floppy disks.
More info here.
9. Floppy Disk Wall Clock
This is a cute one. Make a Floppy Disk Wall Clock using your old Floppy Disks
More info here.
10. Floppy Wallet
Make a floppy wallet to store your cash
More info here.


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I liked this one boy for around 9 months. We talk everyday on msn, he always talks first and says hey or yo. We have long conversations and when one of us leaves we usually text but he's not the texting type. I see him at school all the time and I say hey or give him hugs. So we went to see a movie together with some buddies his friend and mine he went to sit with me but his friend did so in the middle of the movie we all left and me and him got to talk some more, I left with just a goodbye. So a like three months later I told him i like him and his response was "aw id have to know you more to like you" after we didn't really talk so I talked first and said you know how I told you I liked you he said yeah I responded with "i only said that cause I was interested in you so don't be freaked out or anything" he responded with I'm not :) then we started talking like we did before, now is he ever going to date me? If it will. Take time should I still go for him?
Is he ever going to date me? Should I still go for him?
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What Girls Said 2
Give him some time. Get to know him better and see how that goes. If he makes the effort to talk to you and get to know you then it sounds like he's interested. But if he doesn't and you're the one starting the conversations with him majority of the time then he's more than likely just being nice to you because he doesn't want to hurt your feelings.00|00|0
Just keep talking to him, but don't always talk to him first, and maybe be a little mysterious don't give him all he wants. He's gotta chase ya a little ;)
Since he's always initiating the conversations on msn he's gotta be interested, or just goooooood friends. but sounds like he's interested? Give it another month, then ask him again.00|00|0
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text: Has anyone heard of the miracle belt? Someone told me about it today and I was wondering if anyone has tried it and had luck with it. My son has ADHD and anxiety. If this would help him get off medications, that would be good. They really affect his appetite. It would be nice to have him get through homework without adding other medications. Some nights are ok with homework, but it depends on how much homework he has to do. If this really would help him concentrate, that would be great!! That is half the battle with homework and in class at times. Thanks


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John O'Shea trained- Savvy Nature will need plenty of luck in the Group 3 Gloaming Stakes (1800m) at Rosehill Gardens on Saturday after he drew the outside barrier in the 14 horse field.
Savvy Nature will head into the Gloaming Stakes in excellent form after he recorded the biggest win of his racing career in the Group 3 Spring Stakes (1600m) at Newcastle last Wednesday.
The Savabeel gelding travelled towards the tail of the field in the early stages of the race but showed an impressive turn-of-foot when asked for an extra effort by jockey James McDonald to score a decisive win running away from the rest of the field.
While O'Shea is clearly happy with the form of the three-year-old, he admitted that he was disappointed when the Gloaming Stakes barrier draw was announced but is still hoping that his promising galloper can be competitive in the Group 3 event.
"He has a bit of a sod of a gate to be fair," O'Shea told Racing Ahead on RSN.
"He will probably end up going a long way back but there looks to be a bit of speed there with a couple of sprinter/milers of Gai's (Waterhouse) stepping out to 1800.
"We will go back and try to get on the back of Drago at some stage and see if we can't be competitive that way."
Savvy Nature has been included in the nominations for the Group 1 Spring Champion Stakes (2000m) at Royal Randwick on October 12 as well as the Group 1 Victoria Derby (2500m) at Flemington on November 2 and O'Shea is confident that the Spring Stakes winner will continue to improve when he is given the opportunity over longer staying trips.
"That is his forte; he is bred to run a bit of ground," O'Shea said.
"He is a big tough unit and he is just starting to get a bit of fitness now.
"Hopefully he will be more effective as the races get longer."
Savvy Nature has the opportunity to become the first horse to complete the Spring Stakes/Gloaming Stakes double.


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One of the biggest mistakes new designers make is not setting aside enough money and time for their marketing campaigns. They figure, the product will speak for itself. I hate to break it to you, but without marketing materials, no one will know about your line. Marketing goes hand in hand with any business and while it's very important to offer amazing product, it's also essential to promote it in a timely manner. Another reason is that you want to be taken seriously by the buyers you approach. If you don't have the proper branding and marketing collateral like linesheets, business cards, and a lookbook, then how ever will you present your product? Furthermore, how will consumers know about your fabulous new line without a website or a fan page? Now I'm not saying you have to spend an arm and a leg. The beauty of marketing is that you can get creative and use cost efficient tactics. To help you with the basics, here are a list of the top marketing materials every new designer should have under their sleeve.
So the lesson, don't skimp out on marketing! You and your brand are worth it!
If you found value in this post, please like or share it so that other people can also find this information.
Want us to coach you on how to work smarter to grow your fashion business? Contact us at info (at) fabcounsel (dot) com. We've helped entrepreneurs double their sales within the 1st month of working with us because they've gotten more time to focus on business development. Let us know when you're ready for us to do the same for you.


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Es kudi da karnama dekh reh Jaoge Hairan
This girl is so much talented. She folds her stomach and twists it in such a way that all of you will be amazed after watching this video. She draws a sketch on her stomach which looks real. She makes a 3 D sketch on his body and amazed everyone. This video was made in Norway and got view in millions in just a 3 week. This video is being viral on social median now days. Thanks for watching this video.


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Gaffer tape could replace duct tape in your repair kit
By Bob Difley Depending on where you were raised or worked, you may think that "gaffer tape" is a type of tape used to tape up old men — or the boss. But the Gaffer Tape that I was asked to evaluate refers to the tape used by the "gaffer" on movie or TV production sets. The gaffer is... Read More


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