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The University of New Haven (UNH), with its main campus located in West Haven, CT, is a student-centered comprehensive university with an emphasis on excellence in liberal arts and professional education. UNH's mission is to prepare students to lead purposeful and fulfilling lives in a global society by providing the highest-quality education through experiential, collaborative and discovery-based learning. UNH's Henry C. Lee College of Criminal Justice and Forensic Sciences (HCLC) strives to meet this goal by creating a "student-centered professional practice-oriented learning environment."
The Tow Youth Justice Institute (TYJI) was founded in 2014 to support and sustain major youth justice reform efforts now underway in the State of Connecticut and across the northeast, and to increase the use of evidence-based practices in the field. The Institute, as an initiative of the Henry C. Lee College, draws upon the intellectual and other resources of the University to fulfill its mission. Its presence within the University will facilitate interdepartmental collaboration on academic, research, and community service projects and programs.
The mission of the Institute is to prepare the next generation of effective leaders and skilled workers in the juvenile justice field through delivery of an interdisciplinary, experiential curriculum and continuing education programs and to produce valuable, timely research to inform innovative juvenile justice reform efforts in Connecticut and beyond. The Institute is unique in its multidisciplinary, research-driven structure, its diverse partnerships, and its broad scope. The work of the Institute spans academic research, partnerships with public agencies, nonprofits, and community members; curricular development for youth justice advocates, advice to policymakers; and leadership development.
The University of New Haven (UNH), with its main campus located in West Haven, CT, is a student-centered comprehensive university with an emphasis on excellence in liberal arts and professional education. UNH's mission is to prepare students to lead purposeful and fulfilling lives in a global society by providing the highest-quality education through experiential, collaborative and discovery-based learning. UNH's Henry C. Lee College of Criminal Justice and Forensic Sciences (HCLC) strives to meet this goal by creating a "student-centered professional practice-oriented learning environment."
The Henry C. Lee College (HCLC) has the largest and most comprehensive criminal justice program in New England and is the only one with a Ph.D. program in the state. HCLC also has one of the largest international criminal justice programs in the nation. The Tow Youth Justice Institute (TYJI) was established in 2014 to address youth justice issues and to serve as a national model for juvenile justice reform. This academic-based institute is designed to promote, monitor, and evaluate the effectiveness of evidence-based practices, program and policies related to youth justice and child welfare within Connecticut.
The overarching goal of the TYJI is to serve as a center for youth justice reform, provide sustained leadership within the state, foster evidence-based practices in youth justice and become a model for youth justice nationally. The center focuses on four primary objectives toward furthering this goal that aims to increase knowledge, ensure future leadership, and support use of evidence-based practices. The four major objectives are to: • Develop a youth justice leadership training program targeting law enforcement, policy-makers and leaders in public and private agencies • Develop a new youth justice curriculum at the university to ensure future generations of youth justice advocates• Create new interdisciplinary opportunities to enable students to participate in youth justice internships and cooperative work experiences, and• Engage in research and evaluation to advise policy-makers and practitioners on best practices and evidence-based approaches to youth justice reform.
The Tow Youth Justice Institute (TYJI) fulfills an urgent need for a reputable center to inform and support youth justice reform. The TYJI is recognized for effectively promoting juvenile justice issues and assembling both professional and financial resources to address key and long-lasting Connecticut reforms.
Rich connections during year one included an eight-community workshop on juvenile justice produced in collaboration with Connecticut Youth Services Association (CYSA) and the National League of Cities. In addition, juvenile justice reform training for police executives from across the state, as well as a collaborative Training of Trainers for Child Welfare staff were key accomplishments of the Institute. The TYJI staffs the legislature's Juvenile Justice Policy Oversight Committee, and in 2016 embarked on a community leadership program to advance youth justice reforms.
State and Community Engagement: TYJI and Lee College faculty serve on state and community committees, such as the CT Racial Profiling Prohibition Project Advisory Board. HCLC College Dean Mario Gaboury was appointed by the Governor to the Victim's Right's Enforcement Advisory Commission.
New Funds: A grant from the Department of Justice, Office on Violence Against Women (OVW) is creating a campus community where sexual assault, dating violence, domestic violence and stalking are not tolerated. The project involves the university's administration and Governing Board, and a broad representation of student organizations such as the Victimology Club, Psychology Club, Latin American Student Association, Undergraduate Student Government Association, Black Student Union, PRIDE (representing LGBTQ groups), and the Greek fraternal organizations.
· Sponsorship for Cohort Engagement:Community and funder partnerships are essential to support the TYJI process for recruitment, engagement, and leadership skill development of new cohorts. Statewide outreach is critical to the success of the TYJI Leadership Development Program's focus on youth justice reform.
· Broader Institute Communications and Sustainability Plans: Strategic planning will be key to broaden community leader engagement, adopt progressive youth justice policies, and implement evidence-based best practices in juvenile justice.
· Planning and Coordination: Sufficient time for planning will strengthen 1) communications among various UNH Departments, the Institute, and multiple funding entities (federal, state, local public and non-profit sector); 2) prioritization of multiple projects, and liaison with faculty on a set academic and/or research schedules, and 3) allocation of UNH students for new projects.
The Transforming Youth Justice: A Leadership Development Program is designed to promote, monitor and evaluate the effectiveness of evidence-based practices, programs, and policies related to youth justice, focusing on youth up to the age of 21. The TYJI Leadership Program is a new initiative of the Tow Youth Justice Institute (TYJI) that aims to support present and future leaders through a nine month experiential leadership development experience. Cohort groups are limited to 16 diverse individuals representing all aspects of the community and the youth justice system in Connecticut. Selected cohort members enhance their leadership skills and knowledge of juvenile justice reform strategies in order to advise policy-makers on best practices, become resources in organizations and communities, and assure that youth make a healthy transition into adulthood. This group leadership experience combines interactive classroom instruction and small group discussion followed by coaching and peer support during collective "capstone" projects.
Objective 1: Increased participant knowledge and understanding of juvenile justice reform issues and best practices.
Objective 2: Increased abilities for participants to act as agents of change in their own agencies, programs or networks, and to transform policies, procedures, systemic approaches, legislation and actions to better serve youth.
Objective 3: Increased use of personal and professional leadership skills among participants to further reforms, organizational or community level change, and increased self-awareness of leadership style and effective leadership strategies.
Three high priority areas are critical for maintaining the momentum on youth justice, for solidifying leadership at state and local levels, and for positioning Connecticut and the Institute to serve as a national model for reform.
· Youth Justice Reform
Issues include "cross-over" youth in both child welfare and juvenile justice systems, police training about adolescents, exemplary diversion programs, liaison between school and police, responses to mental health needs, reentry in a supportive community, and mediation to reduce conflict and racial tensions.
· Leadership – personal and professional and abilities to promote positive change at community, organizational and statewide system levels, leading to transformational leadership that is "focused on creating a system of self-sustaining change by facilitating a shared vision, recognizing diverse perspectives, and inspiring others to be part of change efforts." (2014, National Council of Juvenile and Family Court Judges, p 32)
· Core Skills, including communications, consensus-building, outreach and access to key leaders, research on innovative and evidence-based program practices, and increased youth and family engagement to improve outcomes and reduce costs.
100% of the cohort participants will demonstrate knowledge and understanding of current juvenile justice reform issues and best practices for juvenile justice.
95 % of participants will demonstrate increased ability and commitment to act as agents of change in agencies, programs or networks through completion of a capstone project. Capstone projects may include implications for transforming policies, procedures, systemic approaches, legislation and/or community actions to better serve youth and families.
95% of participants will demonstrate enhanced personal and professional leadership skills pertaining to systemic reforms, organizational or community level change, and increased self-awareness on leadership styles and effective strategies.
The emphasis will be on learning how to develop new and unique collaborations with entities such as public housing, schools, religious organizations, and affinity groups with a consistent emphasis on strengthening cultural competencies.
In Connecticut, through its landmark legislation, a successful "raise the age" campaign and aggressive reforms, many juvenile justice issues have significantly improved. Connecticut now has the lowest rate of incarcerated youth in the nation, however, more work must be done. Most importantly, there is a need to identify the means to sustain the progress.
The juvenile justice system across the country remains deeply flawed with over-reliance on confinement, insufficient or ineffective services for offenders and families, is racially imbalanced and is connected to an inherent school-to-prison pipeline. According to the Office of Juvenile Justice and Delinquency Prevention, despite a 41% drop in the rate of youth in confinement between 2001 and 2011, youth of color continue to be held in formal supervision and state facilities at much higher rates than white youth.
Connecticut continues in a positive direction and we will find ways to sustain the significant improvements. The vision and generous support of the Tow Foundation working in tandem with the extensive experience in criminal justice at the University of New Haven's Henry C. Lee College, are creating such an opportunity. No other organization in the state or the New England region are dedicated to youth justice issues based on a comprehensive, multi-disciplinary, research-driven model.
The Tow Youth Justice Institute (TYJI) represents a unique opportunity to establish a research-based institute that can support and sustain youth justice reform efforts in the state and the northeast. We will:
- keep a focus on the critical issues in youth justice,
- improve knowledge and diverse leadership capacity in public agencies and nonprofit organizations and local communities, and
- foster academic research to inform best-practices
Through the "Transforming Youth Justice: A Leadership Development Program," the Institute will encourage present and future leaders to guide and expand the youth justice reform efforts and insure on-going system and culture change toward a justice system that will truly provide opportunities for children and families. The Institute, focused on youth up to the age of 21, is a model for sustaining progressive reform and demonstrating how alternative approaches can be institutionalized. We realize that the success of establishing an effective and vibrant institute relies on engagement of a broad range of stakeholders from government, the community and academia.
Mr. William Carbone, Senior Lecturer and Director of Experiential Education at HCLC, and Director for the Tow Youth Justice Institute (TYJI), has recently retired from many years of distinguished service to the State of Connecticut. He became Director of the Tow Youth Justice Institute (TYJI) in 2014, given his extensive experience within the field of juvenile justice.
Mr. Carbone was formerly the Executive Director of the Court Support Services Division (CSSD) in the Connecticut Judicial Branch. He directed and managed over 1,600 employees involved with adult and juvenile probation, family services, juvenile detention, alternative sanctions, and pretrial release. The division was also responsible for a network of private, community based nonprofits that provide services to over 10,000 adult and 1,000 juvenile clients daily. During his time in this position Mr. Carbone was involved as a leader in all of the major juvenile justice reforms accomplished in Connecticut. These included: the reduction in youth incarceration by more than 70%, the largest decrease in the nation; the removal of all status offenders from detention; raising the age of juvenile jurisdiction from 16 to 18; the creation of a continuum of evidence-based programs that have resulted in significant recidivism reduction; and new efforts that have reduced school based arrests. Prior to this he served as Under Secretary of the Management and Justice Planning Division of the State Office of Policy and Management.
Erika Nowakowski, has a Master's degree from the University of CT School of Social Work with a focus on Policy and Planning. She is currently the Director of Juvenile Justice Initiatives with the Tow Youth Justice Institute (TYJI) at the University of New Haven, and is working with the CT Juvenile Justice Policy Oversight Committee in fostering and sustaining youth justice reform efforts. Prior to arriving at TYJI she worked for 8 ½ years for the State of CT Judicial Branch Court Support Services Division as a project manager for several statewide initiatives, Quality Assurance, implementation and ongoing adherence to Gender Responsive Services, contract compliance, and training coordination. She also worked for 4 years with the Council on Accreditation in New York City and provided Technical Assistance to private nonprofit and state agencies seeking accreditation. She also worked with Wheeler Clinic for 3 years in various roles as a case manager with the Emergency Mobile Psychiatric services, managing and coordinating system of care community efforts, and later developing and implementing best practices for recruitment of foster parents.
Donna Pfrommer joined the Tow Youth Justice Institute team as the Director of Development and Communications. She has over 15 years of experience working in the non-profit sector, most recently, ten years at United Way of Coastal Fairfield County focused on resource development, communications, and brand management. At United Way, she raised millions of dollars for community investment, developed marketing campaigns, expanded the organization's presence, and enhanced communications. Pfrommer received her Bachelor's Degree in Marketing from the Dolan School of Business at Fairfield University.
The Tow Youth Justice Institute since its inception in 2014 has exemplified a collaborative initiative. This cooperative effort came through longstanding partnerships involving the University of New Haven, and the Henry C. Lee College of Criminal Justice and Forensic Sciences, the Tow Foundation, the State of Connecticut Judicial Branch, and the Child Health and Development Institute (School Based Diversion Initiative). The Institute embraced stakeholders from state agencies, nonprofits, state and community leaders, police and education, public sector funders, community foundation leaders, and advocacy groups and coalitions. The Institute has convened legislators, policy makers, juvenile justice staff and youth system advocates to hear from respected researchers and reform leaders from states, universities and national justice entities at several TYJI forums on child welfare, restorative justice, police-community relations, data collection, system accountability, and best practices for youth and families. Our collaborators contribute human and financial resources to fuel momentum on youth justice reform. The "Transforming Youth Justice: A Leadership Development Program," demonstrates the Institute's commitment to working with diverse stakeholders to effect systems change. The 2016 cohort of 16 diverse individuals from SCC region represent the critical constituent groups as a strategic step for sustaining future reforms, now members of an Alumni Network. A 2017 second cohort of 16 equally diverse individuals representing the juvenile justice system and local community providers throughout the state began in April 2017 with their 9-month leadership development experience. Six cohort members are again from within the SCC region. The leadership program model deliberately incorporates these trained leaders into a support system for assisting future cohorts and for involvement on the proposed youth justice reforms currently under discussion in Connecticut.
Indirect Public Support HelpIndirect public support represents revenue received through solicitation campaigns. This includes funding United Way and other federated fundraising organizations, but does not include donor designated contributions.
Earned Revenue HelpEarned revenue represents income generated in direct exchange for a product or service.Earned income includes income from government contracts.
The Tow Youth Justice Institute operates under the 501c3 of the University of New Haven. The 990s and audits contained in this profile are those for the University of New Haven. The previous year of financial information in the profile is specific to the University of New Haven.
Greater New Haven's vibrancy is linked to its communities' support of its neighborhoods, public gardens and sports, as well as its commitment to the protection of its people and pets.
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SCOTT SIMON, host:
This WEEKEND EDITION from NPR News. I'm Scott Simon.
(Soundbite of song)
SIMON: Like, I don't know about you, but despite the lyrics to this song, I was astonished to hear the name of this band.
(Soundbite of song)
Mr. MICK FLEETWOOD (Musician): (Singing) The Fleetwood boogie. The Fleetwood boogie. The Fleetwood boogie. The Fleetwood boogie. Oh, and the Fleetwood boogie rocking all night long. Rock it now.
SIMON: The song is called "Fleetwood Boogie," as in Mick Fleetwood. And the band is called the Mick Fleetwood Blues Band. Mick Fleetwood, of course, is the drummer for the legendary band Fleetwood Mac. They're on tour right now, the first time in five years. Mick Fleetwood's Blues Band is Mr. Fleetwood's new band, sort of - new, old, sort of. We'll get him to sort that out. We'll have him explain that later. He joins us from the studios of our esteemed member station WBEZ in Chicago.
Mr. Fleetwood, so nice to have you with us.
Mr. FLEETWOOD: I've never heard so many Fleetwoods in one announcement.
(Soundbite of laughter)
SIMON: And you grew up in that family, so you would have heard a lot.
Mr. FLEETWOOD: Oh, yeah. And anyhow, hello.
SIMON: Well, very nice to talk to you. And now, look, Fleetwood Mac does not have a new album out. The tour is called Unleashed.
Mr. FLEETWOOD: It is.
SIMON: What's that mean?
Mr. FLEETWOOD: Well, it's actually a title that Stevie laid on the table. You know…
SIMON: Stevie Nicks.
Mr. FLEETWOOD: Stevie Nicks, yes.
SIMON: As opposed to Stevie Wonder, yeah.
Mr. FLEETWOOD: That's right. We always need a title for a tour, and Stevie…
SIMON: That's so you can sell T-shirts with the title?
Mr. FLEETWOOD: Well, you just need something for tickets. You need something for T-shirts. And this was - just sounded and felt like sort of what we're doing. We're unleashing the band again and we're going out and actually doing something without an album, like you mentioned, for the first time ever. So there are - we don't have to have the audience sit through five or six or seven new songs. So Unleashed it is. Unleash the hounds.
SIMON: Okay, and now to the Mick Fleetwood Blues Band. It's simultaneously new and old, I gather.
Mr. FLEETWOOD: Well, the band itself is a band that I formed with a dear friend of mine, Rick Vito, who played in the '80s with Fleetwood Mac for a few years. And Rick happened, back in the day, when Fleetwood Mac was formed in '67, was a great fan of the band and, indeed, a great fan of a fantastic guitar player called Peter Green, who formed Fleetwood Mac with me so many years ago in 1967.
The early Fleetwood Mac was very much a blues band. We all came out of having played with John Mayall's Bluesbreakers, the same sorts of histories as Eric Clapton and Mick Taylor from the Rolling Stones, et cetera, et cetera. So there was a whole movement, blues movement, in Europe. And out of that we put an album out, Peter Green's Fleetwood Mac, and it went straight to the top of the English charts.
And you know, the average English listener thought that it was some new musical form that they'd never heard before, which they hadn't. So this band is all about a real passion for blues, the Mick Fleetwood Blues Band. It's a lot of fun and we're able to go back and address the Fleetwood Mac material from the early days. And we also have fun crafting some new material, which is part of our onward-going history, hopefully.
SIMON: Let me ask you about one of the vintage songs, if you please, on this, by Peter Green.
Mr. FLEETWOOD: Uh-huh.
SIMON: Let's listen to a little bit of "Love That Burns."
Mr. FLEETWOOD: Oh, beautiful.
(Soundbite of song, "Love That Burns")
Mr. FLEETWOOD: (Singing) Yeah, you used me like a fool. Baby, my heart can't stand another lie. Don't you use me as a fool. Baby, my heart can't stand another lie. If you can't love me tomorrow, please me leave me now in my lonely pride. In my lonely pride.
(Speaking) Are you crying yet?
(Soundbite of laughter)
SIMON: Yes, I'm barely holding myself together. And so let me ask you a question I suspect…
Mr. FLEETWOOD: Yeah.
SIMON: …Fleetwood Mac fans all over the world ask each other: Where were you the first time you heard this song? Let's change it for you. Where were you the first time you can recall performing this song?
Mr. FLEETWOOD: I do know that we played this song before we recorded it in a pub called The Nag's Head in Brixton. And The Nag's Head could maybe get officially sort of 60 people in it and there used to be like 250, 300 people in there. And those were the sorts of places that this music came out of, and that was our beginnings of Fleetwood Mac.
SIMON: Let's contrast that, a real vintage song, with what, as I understand it, a contemporary song inspired by vintage material, one of Rick Vito's songs, this one - why not - "I Got a Hole in My Shoe."
(Soundbite of song, "I Got a Hole in My Shoe")
Mr. FLEETWOOD: (Singing) I got a hole in my shoe, I got a hole in my shoe, I got a hole in my shoe (unintelligible). I've got a tear in my eyes, a tear in my eye, I've got tear in my eye, ever since you said goodbye, ever since that you said goodbye…
SIMON: I've heard the argument made over the years - I wonder what you think of this, Mr. Fleetwood - that the blues might not be even barely alive today if all these English rockers hadn't discovered it.
Mr. FLEETWOOD: I think there's some truth. In fact, I believe quite strongly that there is a lot of truth in that. This is what us young dudes were doing in London just - and other places in England. I remember the Stones back in the day when they first started touring in the States, and the Stones were basically a blues band, you know, to all intents and purposes.
SIMON: Yeah.
Mr. FLEETWOOD: They, they were horrified that no one had heard of their heroes - you know, Muddy Waters and Otis Span, and etcetera, and Shakey Horton - you know, just endless amounts of people, Bo Diddley, etcetera. And they made some inroads back in the day by putting some of these guys on their, their sort of pop shows in here in the States.
And you're right. I think that whole genre of music was all but dead, and all of these guys used to come over to Europe and be treated like royalty, and the likes of Freddie King and certainly B.B. King. There is no doubt that they, they acclaim these strange little white kids coming over really made a point that that art form is part of a wonderful heritage of the United States of America. And it's nice to know that in some way we were a part of that.
SIMON: You know Twitter?
Mr. FLEETWOOD: No, I don't.
SIMON: Twitter is a, it's a social network. It's - you become a member of Twitter and you send up to 240 characters, short messages to people who are on your network.
Mr. FLEETWOOD: Right.
SIMON: And I send out a tweet, as it's called…
Mr. FLEETWOOD: Okay?
SIMON: …asking people who follow us and our show for questions for you. May I run some questions for you?
Mr. FLEETWOOD: Of course.
SIMON: Okay. A man who identifies himself as Freeman Forth(ph) - and I think this is probably directed towards the Fleetwood Mac part of your career…
Mr. FLEETWOOD: Okay.
SIMON: …it says, he asks: Working that close for so long, did they take time-outs or just throw things at each other? And thanks for the music, always.
Mr. FLEETWOOD: To literally throw things. Well, I think those moments…
SIMON: It might have been metaphorical too.
Mr. FLEETWOOD: No, I think in truth, what one would deem to be the sort of "Rumors" era with Stevie, Lindsay and Christine and John and myself, I think it's well documented and it's certainly public knowledge that we have been fairly dysfunctional at certain points in our history, and I'm sure one or two things were thrown across the room.
SIMON: Piano?
Mr. FLEETWOOD: Maybe a piano, yes, or two. The lovely thing is, we are very aware that we make and enjoy playing music together. It sort of harkens to the Shakespearean phrase - if music be the food of love, play on. And we are playing on.
SIMON: In a different tenor, Thor Spangler(ph) is his moniker, says: Mick has seen a lot of backsides from his perch on the drum riser. Who's is his the most interesting?
Mr. FLEETWOOD: Oh my goodness. Well, the one that's gorgeous and been there, because Chris was always stuck behind the piano. I'd have to say Stevie Nicks. John sometimes wanders in front of the drum riser. Lindsey is running around on stage way too much for me to even get a look.
(Soundbite of laughter)
SIMON: I admire you so for not ducking that question. Thank you.
Mr. FLEETWOOD: Ah, no problem.
SIMON: Is there a song we should go out on?
Mr. FLEETWOOD: I would love you to play, actually, "Albatross," which is, again, it's a Peter Green instrumental and this was our first number one hit all over Europe. And this is my first taste of, of - oh my god, we're becoming famous, I suppose, and look what happened.
SIMON: Mr. Fleetwood, thanks so much.
Mr. FLEETWOOD: You're very welcome.
SIMON: Mick Fleetwood speaking with us from Chicago. He's currently on tour with his old band, Fleetwood Mac, and he has a new album with the Mick Fleetwood Blues Band, which is called "Blue Again."
(Soundbite of music)
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subset: commoncrawl


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Modern technology leaves you with little chance for boredom these days. Where ever you are and what ever you are doing; waiting for a flight, sitting in traffic or grabbing a snack, you can browse the internet! Use the time to browse Red Sea Diving College's latest newsletter or plan your next holiday around our newest last-minute deals.
New PADI App as well
With the latest PADI App for Apple and Android OS based phone or tablet you can instantly find your nearest PADI outlet. You are able to plan your diving by entering your planned destination and receive a list of all PADI dive centre's and resorts in the area. Even better, enter your current location to find the closest PADI centre to you. Results are available in list or map format with contact information, level of centre and some listing even include details of courses offered and brands stocked. This great new App means that, wherever you go, you will always have the option to dive!


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Interested in learning more about reflective practice? Curious about what workshops include? This is the place where you'll find those resources and more. Just click on the links below.
Maybe there's something you're interested in seeing here. Contact me with your ideas and I'll see what I can find for you.
Handouts from Presentations and Workshops
Reflective Writing session_ASHA Healthcare/Business Institute 2010
Improving Patient Experience_Handouts_Presentation at Evergreen Speech and Hearing Clinic
"Evoked Emotion in Counseling: Reflective Writing as a Tool," ASHA Poster 2010
Reflective Writing for Personal-Professional Balance, SPHSC, UW
Reflective Writing for Personal-Professional Balance, ASHA Perspectives article
ASHA Leader story, "Watching in Wonder," 2012
Annotated References
References, "Handling a Bad News Day," ACSLPA 2012
Additional References
References, ASHA 2012, "Reflective Practice for Emotional Balance in Professional Relationships"
The Lecture Circuit: Posts on Treatment Efficacy from Tower to Trenches
Lect Circ 4_Nonstandardized Assessment
Lect Circ 6_Timing of Measurement


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Homes in Hilton Head
Homes in Bluffton
Hilton Head Villas
Bluffton Townhomes
Hilton Head Lots for sale
Bluffton Lots for sale
Foreclosures in Hilton Head
Foreclosures in Bluffton
Hilton Head Short Sales
Bluffton Short Sales
Presenting an opportunity to own a unique second row parcel mere steps away from the beaches of Hilton Head Island. This adorable and quaint two bedroom cottage sits atop a 75'X115' parcel, adjacent to the beachwalk and can be utilized or rented now while the next owner prepares to build new eventually. The cottage is incredibly light, airy, and inviting and may also be purchased in conjunction with the adjacent oceanfront home located at 20 Sea Oak Lane.
Listing presented as a courtesy of Celia Dunn Sotheby's International Realty.


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Men's Style Blog: Summer sartorial survival guide
Summertime is when a man has to look good. It's the time of year memories are made.
Here's a guide to getting your look right this year. The top trends for 2014 are patterns, fitted clothes, and classic styles. The key is buy quality pieces this year that will last you until the weather gets warm again.
The long and short of it is there are a lot of guys who have no idea what to do with a pair of shorts. It seems men either wear shorts that are too baggy or too long.
The right pair of shorts ends about an inch above the knee, has no cargo pockets, and leaves about three inches of room around your thigh. Think of a pair of khakis lopped off about halfway down your leg. That is the style we are aiming for.
A lot of guys cringe at the thought of shorter shorts. What they do not realize is above-the-knee length shorts make legs look longer, which means you in turn will appear taller.
You only need three pairs of shorts to make it through the summer months. Find a style that fits and buy one of each in khaki, navy blue, and a brighter colour or pattern.
There are three shirts a man should wear in the heat: a polo shirt, a short sleeve button up, and a t-shirt.
The overall style for shirts this year is fitted, patterned or colour-blocked, and cut just above the belt. If you are restocking your shirt collection start with neutrals like grey, navy blue, or black. Then graduate to red, yellow, or green.
A polo shirt should not look like something you wear on the golf course. The collar must lie flat on your chest and shoulders. The sleeves should end in the middle of your bicep. Leave the buttons undone or button them all the way up, your call. The key here is fit. Look for shirts with high armholes, about an inch of extra fabric around your midsection, and a close fit in the chest.
The short sleeve button up is tricky. The sleeves should end in the middle of your bicep, but avoid sleeves as wide as wings. I like button down collars because you can machine-wash them without worrying if the collars will get rumpled. Also, we want to avoid the image of your dad on vacation. Keep the shirt fabric close to your body. You will look simultaneously more muscular and slim.
T-shirts should fit like a polo shirt. A word about logos: keep them smaller than your fist. Save the comic book heroes, sports logos, and cheeky phrases for bedtime.
Two words: boat shoes. Buy a pair of leather boat shoes and wear them without socks. If you are looking to add to your collection, a pair of canvas or brightly coloured boat shoes is a nice way to spice up your leather ones.
Also, a pair of brown oxfords will get you anywhere socks are necessary this summer. They go great with shorts, khakis, and chinos.
Flip-flops are for the beach, not walking around town. Man sandals are not a good look for anybody.
Sunglasses, etc.
Wayfarers are classic summer frames. You can buy the original or grab an imitation pair in a similar shape. Make sure your sunglasses fit your face. The bottom of the frame should stop at the top of your cheeks, and the arms should stay tight to your head. If you nod your head and the glasses move, your frames are too big.
Also, get a watch with a canvas strap. All of the big name brands make canvas strap watches, or you can take your leather strapped watch into a store and ask for a canvas band to switch it up for summer. Canvas or cloth bands will keep your wrists cool and will not get sticky in the humidity.
Finally, a word about hats. Stay away from the flat brims. It is not 2009. Buy a good cloth baseball cap with your favourite team on the front. Wear it with the bill forward.
Trust me. Her dad will appreciate it.


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Product or Service
Fertilizer from India; Vermi compost
Profile:Manufacturer - Producer|Ref:PSL211YH | Country: India | Export: No
pioneer in the field of bio fertilizer. Our unique fertilizer is 100 % natural, eco friendly and biodegradable. manufactured with the mixture of cow dung and earthworm. The fertilizer produced by us has highest percentages of nitrogen, phosphorous and potash. In addition minute quantities of essential minerals like zinc, copper, calcium, sulphur, boron and cobalt are also found in it. We follow strict quality standards right from the purchase of raw material till the time of packing and delivery to our respected customers.
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Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary Hypertension
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One intrinsic abnormality of pulmonary artery smooth muscle cells (PA-SMCs) in human idiopathic pulmonary hypertension (iPH) is an exaggerated proliferative response to internalized serotonin (5-HT) caused by increased expression of the 5-HT transporter (5-HTT). To investigate whether 5-HTT overexpression in PA-SMCs is sufficient to produce PH, we generated transgenic mice overexpressing 5-HTT under the control of the SM22 promoter. Studies in SM22-LacZ+ mice showed that the transgene was expressed predominantly in SMCs of pulmonary and systemic vessels. Compared with wild-type mice, SM22–5-HTT+ mice exhibited a 3- to 4-fold increase in lung 5-HTT mRNA and protein, together with increased lung 5-HT uptake activity, but no changes in platelet 5-HTT activity or blood 5-HT levels. At 8 weeks of age, SM22–5-HTT+ mice exhibited PH, with marked increases in right ventricular systolic pressure (RVSP), right ventricle/left ventricle+septum ratio, and muscularization of distal pulmonary vessels, but no changes in systemic arterial pressure. PH worsened with age. Except a marked decrease in Kv channels, no changes in the lung expression of mediators of pulmonary vascular remodeling were observed in SM22–5-HTT+ mice. Compared with wild-type mice, SM22–5-HTT+ mice showed depressed hypoxic pulmonary vasoconstriction contrasting with greater severity of hypoxia- or monocrotaline-induced PH. These results show that increased 5-HTT expression in PA-SMCs, to a level close to that found in human iPH, lead to PH in mice. They further support a central role for 5-HTT in the pathogenesis of PH, making 5-HTT a potential therapeutic target.
Pulmonary hypertension (PH) occurs as a complication of various conditions or develops as a primary disease for which no underlying cause can be found. Medial hypertrophy and intimal thickening of pulmonary arteries are hallmark pathological features that ultimately lead to vessel obliteration.1 Although hyperplasia of pulmonary-artery smooth muscle cells (PA-SMCs) is considered the main component of these changes, the nature of the primary defect responsible for triggering and maintaining PA-SMC proliferation in PH is poorly understood. In particular, to date, whether smooth muscle hyperplasia results from an inherent characteristic of PA-SMCs or from dysregulation of molecular events governing PA-SMC growth is still unknown.2,3
We recently reported that serotonin (5-hydroxytryptamine [5-HT]) and its plasmic membrane transporter (5-HTT) played a central role in the pathogenesis of PA-SMC proliferation in experimental and human PH, whether idiopathic (iPH) or associated with various diseases (aPH).4–6 A key observation is that PA-SMCs from patients with iPH or aPH proliferate excessively when they are exposed to 5-HT.6 In contrast, these cells proliferate to the same extent as PA-SMCs from control subjects when they are stimulated by various growth factors such as PDGF, EGF, FGF, IGF, or TGF-β.5 This abnormal response to 5-HT is attributable to overexpression of 5-HTT, which leads to increased internalization of indoleamine, whose intracellularly mediated mitogenic action is therefore enhanced.7,8 PA-SMCs from patients with iPH maintain increased 5-HTT expression when cultured, ie, removed from their in vivo environment, suggesting that increased 5-HTT expression by these cells may be a cardinal alteration in PH.5,6 However, it is not known whether 5-HTT overexpression occurring selectively in PA-SMCs is sufficient to produce PH in vivo. This point is of particular importance because 5-HTT expression is controlled by many factors, including polymorphism of its gene promoter, hypoxia, inflammatory cytokines, and drugs known to increase the risk of iPH in humans.5,8–10 Previous studies showed greater severity of hypoxic PH in transgenic mice that overexpress 5-HTT than in wild-type controls.11 However, these transgenic animals also exhibit 5-HTT overexpression in various cell types in addition to PA-SMCs, including platelets, fibroblasts, endothelial cells, and neurons, which may lead to major changes in central and peripheral 5-HT bioavailibility. In a previous study of monocrotaline-induced PH in rats, we found that increased 5-HTT expression preceded the onset of PH, suggesting that 5-HTT overexpression occurred upstream to PH development in this model.9 However, many biological abnormalities are associated with the onset of PH in monocrotaline-treated rats, which likely interfered with the specific action of 5-HTT in the process of pulmonary vascular remodeling.
In the present study, we generated mice that overexpressed 5-HTT under the control of the smooth muscle promoter SM22 (SM22–5-HTT+ mice). The SM22 promoter was chosen because it drives preferential expression of transgenes in vascular smooth muscle (compared with visceral smooth muscle) and in arteries (compared with veins).12 We addressed the following questions. (1) Do SM22–5-HTT+ mice spontaneously develop PH in the absence of associated or environmental stimuli? (2) Does PH induced by 5-HTT overexpression occurring selectively in PA-SMCs share some of the pathological and biological abnormalities encountered in human PH? (3) Are SM22–5-HTT+ mice more susceptible than paired wild-type mice to PH induced by various stimuli including exposure to hypoxia or treatment with the active monocrotaline derivative monocrotaline-pyrrole?
Materials and Methods
Production of SM22–5-HTT+ and SM22-LacZ+ Transgenic Mice
Transgenic animals were produced as previously described.12 The murine SM22 promoter (2191 bp starting 2126 bp before the start site) was used to drive expression of the human 5-HTT gene or the LacZ gene. All animal care and procedures were in accordance with institutional guidelines.
Immunoblotting and Immunostaining
The tissues were sonicated in PBS containing anti-proteases, and 150 μg of protein from each sample was used to detect 5-HTT protein as previously described.4 The 5-HTT and β-galactosidase proteins were immunocytochemically labeled with polyclonal antibodies (Chemicon, Hampshire, UK) directed against 5-HTT and β-galactosidase (1:1000), respectively, as previously described.4
Lung and Platelet [3H]5-HT Uptake
Lung tissues were homogenized in the uptake buffer (120 mmol/L NaCl, 5 mmol/L KCl, 1.2 mmol/L CaCl2, 1.2 mmol/L MgSO4, 5.6 mmol/L glucose, 4 mmol/L Tris-HCl, 6.25 mmol/L HEPES, and 0.5 mmol/L ascorbic acid, pH 7.4). Platelet and lung [3H]5-HT uptake were measured with and without fluoxetine (10−5 mmol/L), according to a previously described protocol.4
Blood 5-HT and 5-HIAA Concentrations
Serotonin and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were assayed in whole blood using electrochemical detection by high-performance liquid chromatography.13
Measurement of Systemic Arterial Pressure in Normoxic Mice
To measure systemic arterial pressure, animals were anesthetized with ketamine (60 mg/kg IP) and xylazine (10 mg/kg IP). The right carotid was exposed, and a polyethylene catheter was inserted into the carotid artery then connected to a pressure transducer.4
Assessment of PH
Mice were studied at 8, 20, and 55 weeks of age. Right ventricular systolic pressure (RVSP) and heart rate were recorded and the Fulton index (right ventricle/left ventricle plus septum [RV/LV+S]) was determined as previously described.4 The lungs were removed, fixed, and processed for paraffin embedding. The percentage of muscularized vessels was calculated as previously described.4 The cell proliferation rate in muscularized vessels was estimated by proliferating-cell nuclear antigen (PCNA) staining.9
Real-Time Quantitative PCR
Real-time quantitative PCR (RTQ-PCR) was used to measure lung levels of mRNAs encoding 5-HTT, bone morphogenetic protein receptor (BMPR)-II, BMPR-1A, BMPR-1B, BMP-2, BMP-4, endothelin-1 (ET-1), Tie-2 receptor, prostacyclin (PGI2) synthase, voltage-gated potassium channel (Kv)1.2, Kv1.5, Kv2.1, and Kv9.3, as previously described.9
Effects of 5-HTT Activation on Kv Channel Expression in Cultured Human PA-SMCs
The effects of 5-HT on Kv1.5 and Kv2.1 expression were studied on cultured human PA-SMCs collected as previously described.5 Synchronized cells were exposed to 5-HT (10−6 mol/L) with or without fluoxetine (10−6 mol/L) in serum-free medium for 4 hours before RNA extraction.
Hemodynamic Response of Normoxic Mice to Acute Hypoxia
Right ventricular systolic pressure and heart rate were performed first while the animals were ventilated with room air then after 5 minutes of ventilation with a hypoxic gas mixture (8% O2, 92% N2).4
PH Induced by Exposure to Chronic Hypoxia or by Treatment with Monocrotaline Pyrrole
Mice aged 8 weeks received a single IV injection of the active monocrotaline derivative monocrotaline pyrrole (MCT-P) (5 mg/kg) or were exposed to chronic hypoxia (10% O2, 90% N2). Preliminary experiments revealed that intravenous administration of MCT-P induced PH within 15 days. PH and vascular remodeling were evaluated 2 weeks following hypoxia exposure or MCT-P injection.
Statistical Analyses
Data are presented as the means±SE. Statistical significance was tested using the nonparametric Mann–Whitney test or 2-way ANOVA followed by the Student–Newman–Keuls test.
Validation of Transgene Function and Tissue Distribution
Lung transgene expression by 8-week-old transgenic SM22–5-HTT+ mice was measured using RTQ-PCR and Western blot for 5-HTT mRNA and protein, respectively. SM22–5-HTT+ mice showed a marked increase in lung 5-HTT expression compared with wild-type controls, with 3- to 4-fold increases in 5-HTT mRNA and protein levels (Figure 1). Accordingly, lung [3H]5-HT uptake was 3 times higher in SM22–5-HTT+ mice than in wild-type mice, whereas platelet [3H]5-HT uptake did not differ between the 2 strains (Figure 2). To further validate the use of the SM22 promoter, we generated SM22-lacZ+ mice. As shown in Figure 3A, SM22-lacZ+ mice demonstrated β-galactosidase immunostaining in the media of pulmonary arteries but not in the bronchi. Most of the pulmonary vessels were stained, indicating diffuse transgene expression throughout the pulmonary vasculature. Immunohistochemical studies were also performed to visualize 5-HTT–like immunoreactivity in pulmonary vessels of transgenic SM22–5-HTT+ and wild-type mice. As shown in Figure 3B, 5-HTT immunostaining was detected in pulmonary arteries from both SM22–5-HTT+ and wild-type mice but with greater intensity in the transgenic mice.
Blood 5-HT and 5-HIAA Levels in Transgenic SM22–5-HTT+ Mice and Wild-Type Mice
Whole-blood 5-HT levels did not significantly differ in SM22–5-HTT+ mice and wild-type mice (21.0±1.5 and 20.8±1.6 μmol/L, respectively; means±SEM, n=6 in each group). Similarly, blood 5-HIAA levels were similar in transgenic (0.612±0.040 μmol/L, n=5) and wild-type (0.716±0.048 μmol/L, n=5) mice.
Development of PH and Vascular Remodeling in SM22–5-HTT+ Mice
SM22–5-HTT+ mice (8-weeks old) did not differ from wild-type mice with respect to body weight (23±1 g versus 22±2 g, P=NS), systemic arterial pressure (93±5 mm Hg versus 91±3 mm Hg, P=NS), or heart rate (360±14 bpm versus 342±11 bpm, n=6 in each group, P=NS). In contrast, RVSP and RV/LV+S weight ratio were significantly higher in SM22–5-HTT+ mice than in wild-type controls, indicating the presence of sustained PH in transgenic mice (Figure 4). SM22–5-HTT+ mice experienced PH progression over time, with higher RVSP values at 55 weeks than at 20 weeks and at 20 weeks than at 8 weeks (Figure 4A). Concomitantly, SM22–5-HTT+ mice developed marked pulmonary vascular remodeling, as shown by increased density of muscularized pulmonary vessels in SM22–5-HTT+ mice at any age compared with wild-type mice (Figure 4C). As illustrated in Figure 4, muscularization was more prominent in 20-week-old mice than in 8-week-old mice and was greatest in 55-week-old mice. In SM22–5-HTT+ mice, PCNA labeling showed proliferation of smooth muscle cells in distal pulmonary vessel walls (Figure 4D). PCNA-positive cell counts were 60±6% and 55±12% in muscularized pulmonary vessels from SM22–5-HTT+ mice aged 20 and 55 weeks, respectively, compared with 6±2% in vessels from wild-type mice (P<0.01).
Lung Molecular Alterations Induced by 5-HTT Overexpression in SM22–5-HTT+ Mice
We investigated whether development of PH in SM22–5-HTT+ mice was associated with changes in the expression of genes involved in pulmonary vascular remodeling. Using RTQ-PCR, we found that lung levels of mRNAs encoding ET-1, Tie2 receptor, prostacyclin-synthase, BMPR-2, BMPR-1A, BMPR-1B, BMP-2, BMP-4, Kv1.2, and Kv9.3 were not altered in SM22–5-HTT+ mice compared with wild-type controls (Figure 5). In contrast, both Kv1.5 and Kv2.1 mRNA levels were markedly decreased in lungs from SM22–5-HTT+ mice compared with controls at 20 weeks of age (Figure 5C). Because Kv1.5 and Kv2.1 channels are predominantly expressed by SMCs,14 we performed additional in vitro studies on human PA-SMCs to examine the effect of 5-HT on the expression of these channels. As shown in Figure 6, incubation of PA-SMCs with 5-HT (10−6 mol/L) for 4 hours dramatically reduced Kv1.5 mRNA levels. This effect was abolished by the selective 5-HTT inhibitor fluoxetine (10−6 mol/L).
Hemodynamic Responses to Acute Hypoxia
The effect of an acute hypoxic challenge on RVSP was examined in 20-week-old normoxic mice (Figure 7). Exposure to 8% O2 elicited a marked increase in RVSP in wild-type mice (from 18.2±0.6 to 23.1±0.7 mm Hg; P<0.01) but not in SM22–5-HTT+ mice (from 28.1±0.7 to 28.6±0.6 mm Hg). Heart rates were similar in transgenic and wild-type mice.
PH in SM22–5-HTT+ and Wild-Type Mice After Exposure to Chronic Hypoxia or Treatment With Monocrotaline-Pyrrole
These experiments were performed to investigate whether PH induced by chronic hypoxia or MCT-P was more severe in SM22–5-HTT+ mice than in wild-type mice. Mice aged 8 weeks were used for these studies. Fifteen days after exposure to 10% O2 or treatment with MCT-P, both SM22–5-HTT+ and wild-type mice exhibited increases in RVSP (Figure 8A), Fulton index (Figure 8B), and muscularization of pulmonary vessels (Figure 8C) compared with preexposure values. However, the RVSP increase and degree of RV hypertrophy and distal pulmonary vessel muscularization were more severe in SM22–5-HTT+ mice than in wild-type mice following administration of MCT-P or exposure to hypoxia (Figure 8).
Our results show that transgenic mice with 5-HTT overexpression occurring selectively in SMCs spontaneously develop PH. Because 5-HTT overexpression in PA-SMCs is a characteristic of human iPH or aPH, these data indicate that 5-HT internalization by PA-SMCs plays a prominent role in the pathogenesis of human PH. One major point is that PH in SM22–5-HTT+ mice developed despite unaltered 5-HT bioavailibility, solely as a consequence of increased 5-HTT protein expression in SMCs. We found that genes belonging to the BMP pathway and genes expressed by endothelial cells, whose expression is usually altered in human or experimental PH, remained unaltered in the lungs of SM22–5-HTT+ mice. In contrast, the expression of Kv channels which are predominantly expressed by PA-SMCs, was lower in SM22–5-HTT+ mice than in wild-type mice. Compared with wild-type mice, SM22–5-HTT+ mice showed depressed hypoxic pulmonary vasoconstriction but developed more severe hypoxia- or monocrotaline-induced PH.
The main question addressed in this study was whether induction in mice of an intrinsic abnormality constantly found in PA-SMCs from patients with various forms of PH was sufficient to induce PH in the absence of other stimuli. The use of the SM22 promoter to drive 5-HTT expression selectively in SMCs caused a 3- to 4-fold increase in lung 5-HTT protein levels. SM22–5-HTT+ mice studied at 8 weeks of age developed PH, as reflected by significant increases in RVSP, Fulton index, and muscularization of distal pulmonary vessels. Increased PA-SMC proliferation appeared to be the main factor in pulmonary vascular remodeling in SM22–5-HTT+ mice, as reflected by the increased PCNA labeling of pulmonary vessels. PH worsened with age, as a result of progressive pulmonary vessel remodeling. The level of increased 5-HTT expression in SM22–5-HTT+ mice was very close to that found in humans with PH. 5-HTT expression in PA-SMCs from patients with iPH or aPH is usually 2- to 4-fold that of control subjects, depending on the type of PH and on the individual genotype.5,6 The fact that SM22–5-HTT+ mice spontaneously developed PH therefore indicates that vascular 5-HTT overexpression per se is sufficient to induce PA-SMC hyperplasia and subsequent development of PH.
The 5-HTT protein is known to be responsible for the internalization and storage of 5-HT in platelets and neurons. Consequently, changes in 5-HTT expression might be expected to induce major changes in circulating 5-HT levels and/or 5-HT bioavailability in the central nervous system and in peripheral tissues. Although in previous studies, transgenic mice with 5-HTT overexpression driven by the human 5-HTT gene promoter were more susceptible to hypoxic PH than wild-type mice, these transgenic mice probably had additional alterations in 5-HT bioavailibility.11 In our study, these alterations were limited by the use of a promoter that was selective for SMCs. As a consequence, neither platelet 5-HT uptake nor blood levels of 5-HT or its metabolite 5-HIAA differed significantly between transgenic and wild-type mice. Thus, another striking finding from our study is that 5-HTT protein overexpression in SMCs led to pulmonary vascular remodeling and PH despite the absence of associated changes in indoleamine bioavailability.
It is noteworthy that in SM22-LacZ+ mice the SM22 promoter was found to direct lung β-galactosidase expression chiefly in the media of pulmonary arteries, inducing only faint β-galactosidase immunostaining in bronchial SMCs. This observation is consistent with previous studies showing that the SM22 promoter drives preferential expression of transgenes in vascular smooth muscle, as opposed to visceral smooth muscle.12 In SM22–5-HTT+ mice, the 5-HTT expression increase occurred in the media of all types of vessels, including pulmonary and systemic arteries. However, vascular remodeling developed only in the pulmonary circulation of the transgenic mice, which exhibited no structural changes in the carotid arteries or differences in blood pressure compared with wild-type mice. The differential effects of 5-HTT overexpression in pulmonary versus systemic vessels are consistent with our previous findings that the mitogenic effect of 5-HT on SMCs is mediated by 5-HTT only in PA-SMCs.8 These findings are of clinical relevance because they suggest that conditions associated with increased 5-HTT expression in a given individual might predominantly affect pulmonary vessels. SM22 is expressed in the embryonic pulmonary vasculature, raising the possibility that pulmonary vascular remodeling may have developed in SM22–5-HTT+ as a result of a congenital defect in the pulmonary vasculature. However, examination of pulmonary vessels from neonatal animals failed to show marked differences between SM22–5-HTT+ and wild-type mice.
Investigating SM22–5-HTT+ mice has shed light on relationships between molecular pathways known to affect pulmonary vascular remodeling. First, BMPRII has been identified as the gene causing familial PH, and BMPRII+/− mice were recently shown to be more susceptible than control mice to PH induced by inflammatory stimuli.15–17 BMPRII+/− mice, however, do not develop PH spontaneously.17 We investigated the BMP pathways in SM22–5-HTT+ mice by measuring lung expression of BMPRII, BMPRIa, BMPRIb, BMP-2, and BMP-4. No alterations in lung levels of mRNAs encoding these molecules were found, suggesting that the BMPRII pathway was not involved in PH in SM22–5-HTT+ mice. Second, we investigated whether endothelial cell alterations might have contributed to PH in SM22–5-HTT+ mice. A consistent feature of various types of experimental or human PH is increased lung expression of ET-1, which may be associated with downregulation of prostacyclin synthase and activation of Tie2 receptors.18–21 In lungs from SM22–5-HTT+ mice, expression of ET-1, Tie2 receptor, and prostacyclin synthase was not significantly different from that in wild-type animals, suggesting that PH in these transgenic mice developed without a major contribution from endothelial cells. Third, key actors of the contractile and proliferative status of PA-SMCs are voltage-gated K channels (Kv) including Kv1.2, Kv1.5, Kv2.1, and Kv9.3.14 It is now well established that blockade or downregulation of Kv channels, notably Kv1.5 and Kv2.1, causes membrane depolarization and stimulates PA-SMC proliferation.22,23 Inhibition of 1 or several of these channels by acute hypoxia also contributes to initiate hypoxic pulmonary vasoconstriction.22,24 Because reduced expression of these channels is a characteristic feature of human idiopathic PH and of hypoxia-induced PH,22,25,26 1 current hypothesis is that downregulation of Kv channels contributes importantly to the pathogenesis of various types of experimental and human PH. In our study, lung expression of both Kv1.5 and Kv2.1 channels was markedly decreased in SM22–5-HTT+ mice. Interestingly, treatment of human PA-SMCs by 5-HT in vitro induced a similar marked reduction in the expression of Kv1.5 channels, indicating that downregulation of this channel was not related to the remodeling process per se, but rather appeared to be a downstream effect of 5-HT internalization by these cells. Therefore, a direct link between 5-HTT and Kv channels might explain why these membrane-bound proteins show opposite variations in PH of various origins. The molecular link between 5-HTT and Kv channels remains to be identified, although downstream effects of 5-HTT activation may involve NADPH oxidase activity,27 which has been shown to alter Kv channel expression and/or activity.28,29 One may suggest that some of the cellular effects of 5-HTT overexpression in SM22–5-HTT+ mice were mediated by downregulation of Kv channels. Although such a hypothesis is beyond the scope of our study, some of the functional abnormalities in SM22–5-HTT+ mice were probably related to changes in Kv channels. Indeed, it is now well established that 1 direct consequence of Kv channel downregulation is a reduction in the extent of hypoxic pulmonary vasoconstriction.22 Interestingly, in SM22–5-HTT+ mice, the pulmonary pressure response to hypoxia was completely abrogated, indicating that these mice are unresponsive to acute hypoxic vasoconstriction. These results are consistent with those obtained during chronic hypoxia, where increased PA-SMC proliferation coexists with blunted hypoxic vasoconstriction because PA-SMCs are in a depolarized state. Moreover, these results agree with our previous finding that hypoxic pulmonary vasoconstriction in 5-HTT knock-out mice was, on the contrary, potentiated.4
Although SM22–5-HTT+ mice did not develop hypoxic pulmonary vasoconstriction, they experienced PH of greater severity compared with wild-type controls after exposure to chronic hypoxia or the monocrotaline pyrrole derivative. In previous studies in both rats and mice, we found that these 2 types of PH were associated with 5-HTT overexpression and that deleting the 5-HTT gene or pharmacologically inhibiting 5-HTT activity protected against hypoxia- or monocrotaline-induced PH.4,9 5-HTT+ mice did not appear more sensitive to chronic hypoxia or to monocrotaline than wild-type mice, indicating that 5-HTT overexpression did not act synergistically with hypoxia or monocrotaline to cause PH. These results are consistent with the fact that 5-HTT transgene expression, in contrast to the 5-HTT gene, is unresponsive to external stimuli such as those induced by hypoxia or monocrotaline.8,9 Our results are, therefore, consistent with the proposal that the level of 5-HTT expression is an important modifier of the PH phenotype, whatever the cause of PH. In line with this conclusion, we recently provided evidence that the severity of PH in patients with chronic obstructive lung disease is closely related to polymorphism of the 5-HTT gene promoter.30 In particular, PH was particularly severe in patients who carried the biallelic L form of the 5-HTT gene promoter. Polymorphism of the 5-HTT gene promoter, however, cannot explain the high expression of 5-HTT in PA-SMCs from patients with either iPH or aPH. Whether increased 5-HTT expression occurs as a primary defect or is secondary to other abnormalities in human PH remains an unsolved question. In any case, our results in mice demonstrate clearly that 5-HTT overexpression is a key factor during PH development. SM22–5-HTT+ mice should now be considered a useful in vivo model for investigating how environmental and/or genetic factors modify their PH phenotype.
This research was supported by grants from INSERM, the Ministère de la Recherche, the Délégation à la Recherche Clinique de l'AP-HP, and the Fondation de France. The study was performed with the support of the "plate-forme petit animal" IFR10, Creteil, France.
Original received October 29, 2005; revision received March 16, 2006; accepted April 5, 2006.
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- Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary HypertensionChristophe Guignabert, Mohamed Izikki, Ly Ieng Tu, Zhenlin Li, Patricia Zadigue, Anne-Marie Barlier-Mur, Naïma Hanoun, David Rodman, Michel Hamon, Serge Adnot and Saadia EddahibiCirculation Research. 2006;98:1323-1330, originally published May 25, 2006https://doi.org/10.1161/01.RES.0000222546.45372.a0
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- Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary HypertensionChristophe Guignabert, Mohamed Izikki, Ly Ieng Tu, Zhenlin Li, Patricia Zadigue, Anne-Marie Barlier-Mur, Naïma Hanoun, David Rodman, Michel Hamon, Serge Adnot and Saadia EddahibiCirculation Research. 2006;98:1323-1330, originally published May 25, 2006https://doi.org/10.1161/01.RES.0000222546.45372.a0Permalink:


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GPPPoE-Conf is a graphical application made with GTK 2 to create PPPoE accounts used by pppd. It also contains a script for configurating Speedtouch ADSL modems. This program was formerly known as "Speedtouch Installer".
|Networking Installation/Setup Utilities Internet
|Operating Systems
|POSIX Linux
|Unix Shell Tcl
Release Notes: speedtouch-pppoe 1.4.1 adds stable support for kernel drivers, more system checks and configurations, and code cleanup. gpppoe-conf had a typo in the speedtouch configuration. This is the first release of pppoe-conf, the command line version.
Release Notes: Fixes for a typo and a few bugs related to the "install" tool.
Release Notes: This version corrects a bug in installer.tcl, re-orders the questions on "installer", and updates the way "speedtouch" works to make it more general; it now uses a config file instead of hardcoded options.
Release Notes: This release fixes the speedtouch and installer scripts.
Release Notes: An installation bug was corrected.
A Fluent OpenStack client API for Java.
A TWiki appliance that is easy to use and lightweight.


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As a child I had to take my vitamins just like everyone else.
Naturally, me being me, I was stubborn and just did not want to have it.
Now, I am a mom. I get the pleasure of facing the same battle my mom fought with me.
My son is pretty good with eating healthy. Now he may not be a huge fan of fruits and veggies but he does know he has to eat them or he will be at the table all evening. But I still worry and want him to get all of his vitamins. After all, he is a growing boy.
He has gotten better over the years with his pickiness but I still think a multivitamin is benifical.
Which brings me to Rainbow Light.
The first thing I want to point out is that this particular brand has a double seal going on. I see some companies lack this which it does bother me a bit. I know may seem weird but it does. I like when any type of medicine or vitamin is double sealed.
Just like to know what I am about to consume hasn't been tampered with. Can't blame me there, right?
I will say this. These vitamins, mainly the woman's, are not the prettiest of things. Now that isn't what a vitamin is about so it really isn't a huge deal. You are just going to eat it anyways. Now my son does like that his were a shape of a star. He thought that was pretty cool. He actually learned how to draw a star recently and is pretty excited about it. So, yeah, anything stars is cool right now. Hehe
Of course here is my little model testing out his vitamin. He was a bit unsure at first but after a few days of taking them he enjoyed them. Still loves that they are stars.
Now anytime I take photos with Jaiden we always have fun. We get some great shots and some not so great shots. My favorites of these are the ones above. I love the silly faces. He is such a great sport for putting up with me and my camera.
Now on the bottle of the Rainbow Light Vitamins it says 'New Look, Same Formula!'. So I googled to see what their old bottles look like and I have to say this new look is much more appealing. When you have a product that isn't appealing to the eye it is kind of hard to move it. I love the new look compared to their old design. It's more bright and colorful, easy to read and clear.
Rainbow Light has been around since 1981!! Now being honest, I had no idea they had been around this long!!
"Our mission is to be the performance leader in building a stronger state of health for our customers, natural trade partners, global community and planet."
Here are the links to each product. You can find their description and supplement value.
Kids One | Womans One
Overall we truly enjoyed our Rainbow Light Multivitamins.
We loved the packaging, and Jaiden adores that his were in the shape of stars.
Besides having a great product, Rainbow Light is an amazing company and truly cares about their customers.
Be sure to check them out and remind your little ones they need to take their vitamins! It's important!
Facebook | Twitter | Pinterest | Youtube | Linkedin
Disclosure: I received the products mentioned above in an exchange for my honest review. No other compensation was provided. All opinions are 100% my own.


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Agriculture Minister Sam Sesay says that every part of the Moringa plant is chock full of both nutritional and medical value and that it is able to treat or cure more than 300 illnesses. While doctors don't necessarily agree with that claim, they do agree that it has value. Local doctors are using it to complement their treatments.
Sierra Leone is a poor country and many of the children die before the age of five. There are few doctors or nurses and most live on less than $1 a day. The Moringa plant is also helping in that department, as farmers are being shown how to plant and harvest the "miracle" plant. The United Methodist Committee on Relief is promoting the use of Moringa in Africa and brought the seeds of the Moringa to Sierra Leone more than 10 years ago and gave it to 150 farmers to raise.
Samples of the plant have also been distributed to more than 2,000 area residents in the city of Makeni to encourage its use. It comes as a tea or a powder that can be sprinkled on foods. Besides being a health aide, it is also helping people with jobs and more than 250,000 seeds have been distributed to encourage people to grow and sell it to earn money.
A factory has also been build to market the plant to other areas of the world.
The Moringa is said to have seven times the vitamin C found in oranges, four times the calcium in milk, four times the vitamin A in carrots and three times the potassium found. It also has more than 46 antioxidants and lots of phytonutrients, which get rid of toxins in the body, cleanse the liver and boost the immune system.


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Selected Publications
In April 2016, AsterixDB was awarded top-level project status by the Apache Software Foundation (for details, please visit the AsterixDB project website). An overview of AsterixDB may be found in the following paper:
- AsterixDB: A Scalable, Open Source BDMS
Authors: Alsubaiee S, Altowim Y, Altwaijry H, Behm A, Borkar V, Bu Y, Carey M, et al.
Download file: PDF
The Cloudberry demo is explained in this working paper:
- Towards Interactive Analytics and Visualization on One Billion Tweets
Authors: Jia J, Li C, Zhang X, Li C, Carey MJ
Download file: PDF
The following two articles are especially relevant to UCIPT as infrastructure for managing Big Data in support of prediction work:
- Large-scale Complex Analytics on Semi-structured Datasets using AsterixDB and Spark
Authors: Alkowaileet W, Alsubaiee S, Carey M, Westmann T, Bu Y
Download file: PDF
- BigFUN: A Performance Study of Big Data Management System Functionality
Authors: Pirzadeh P, Carey M, Westmann T
Download file: PDF


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The Rancho Cucamonga Quakes defeated the visiting Lake Elsinore Storm, 8-6, on Saturday night at LoanMart field.
Cody Bellinger led the Quakes (22-13), going 2 for 4 with RBI doubles in the sixth and eighth innings, and Devan Ahart hit a two-run home run in the fifth.
Paul Hoenecke added two doubles and an RBI and Kyle Farmer and Joey Curletta each had an RBI.
For the Storm (16-19), Fernando Perez went 2 for 5, with a two-run homer in the third, and Jose Rondon added a two-run home run in the eighth. Donavan Tate hit a two-run triple in the fifth.
Victor Araujo pitched 21/3 perfect innings, striking out five, for the win.
Inland Empire 3, Lancaster 2: Mark Shannon hammered a bases-clearing double in the bottom of the ninth inning and the 66ers beat the JetHawks at home.
The JetHawks (17-19) got on the board in the fifth when Brett Phillips doubled to score Jose Fernandez.
Fernandez homered in the seventh inning to put Lancaster up, 2-0.
Trevor Foss picked up the win as the Inland Empire improved to 17-17.


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Information for Piecers and Quilters
Other links of interest:
Making Blocks
Making Middling Quilts
There are so many ways to be part of The 70,273 Project Tribe and help commemorate these 70,273 disabled people who were murdered by Nazis in 1940-41. Perhaps you want to make blocks, or maybe you want to gather blocks from others who share your genes, geography, or interests and make a group quilt with them. (And hey, there will be other ways to participate coming here in the next several months, so subscribe or check back often.) Maybe you want to help commemorate these 70,273 victims in more than one way. And perhaps you want to raise your hand with an offer to piece tops, quilt quilts, or piece and quilt . . .
A big, hearty Thank you to all the people who've graciously donated their time and talent to piece, quilt, or piece and quilt quilts for The 70273 Project. If you, your guild, or your group would like to add your names to this Honor Roll, let me know by mashing the envelope icon in the sidebar to the right of the page to send an email.
While I am excited about how each quilt is going to reflect the personality of its maker(s), and while I do want quilts of all sizes – something to fit in every venue that will have us – I do have a few strict parameters that we all must follow when piecing and quilting these works of art. I've listed them below. If you have any concerns, questions, comments, or suggestions, just holler.
Here's how it works . . .
§ When you're ready, I will send you a bundle of blocks. There might be 50 blocks, there might be 80 blocks – it all just depends because I want you to have room to be creative. Your job is to use as many blocks as you can in the top, assembling them in a way that delights you. Please return to me any blocks you do not use so that I can make amendments to my record keeping system and add the unused blocks to a bundle headed to another Piecer.
§ When I receive blocks, I assign each block a number, and the block is marked with the id number it's been assigned. Blocks are tagged in one of two ways: the number may be on a bit of paper that's attached to the front of the block or it may be written by hand on the back of the block. Please do not remove the numbering tags from any of the blocks during the process. This is critical for tracking the thousands and thousands and thousands of blocks that will be transformed into quilts. I have a very precise cataloging system that will allow me to provide the all-important authorization documentation for exhibit venues, art historians, and viewers. Here's good information from Trish Lehman, a quilter, about documenting the block numbers that will later be used to create the quilt map, showing the placement of each block and its Maker:
A very important part of the cataloging process is to ensure that the id numbers remain on each block during the piecing and quilting process. Once the blocks are arranged to a Piecer's delight and before they are stitched together, Piecers create a map or record of their final layout with tag numbers clearly visible before the piecing and quilting begins. This could be done in a couple of ways:
- Sketch the final layout on a piece of plain paper or graph paper (for more precision) and write the number in each square.
- Take a photo of your final layout on your design wall or on the floor, print it out, and write the number in each square.
If the blocks you receive have the numbers handwritten on the back of the blocks, you might create the sketch (making sure that you flip the sketch so that the blocks appears as they will to the viewer, or you may find it easier to stitch the blocks together THEN take a photo of both the front and back of the top, making sure that the block numbers are visible and readable when the photo is enlarged.
Please send any photos and sketches to Jeanne so she can create the final quilt map for inclusion on the quilt label, and if you're not quilting, send it to the person who is. Of course, if you are making your own quilt from blocks you made, none of this will be necessary as the quilt label will say that all blocks are made, pieced, and quilted by you.
§ If a blocks are too small, please add fabric to enlarge it to the standard size. Conversely, if a block is to large, please trim it to the standard size.
§ Blocks can be turned vertically or horizontally as you see fit.
§ lf another block would make things work more to your liking, it's fine to make one provided you let Jeanne know right away so she can add it to the catalogue. She'll need to know the size of the block, too.
§ Add 2-inch border of white fabric must to each side of the finished quilt. (Cut 2.5 inches so that it is 2 inches when finished.)
§ If you are handing off the quilt to another person to be quilted and you have designed the quilt with a definite orientation (the quilt should be displayed with one particular edge at the top), please indicate that on the quilt by pinning a note to the edge that is to be the "TOP".
§ Kitty Sorgen pieced the first top for The 70273 Project, and she penned these notes for future Piecers:
Thank you for volunteering to do the piecing of one of the quilts for the 70273 Project! Your help is vital to the success of this endeavor. Below are a few guidelines that may be helpful to you. When you first receive your packet of blocks, it may feel overwhelming. You may feel, like I did, that you're in over your head. Take a deep breath, and let's break down what you're going to need to do.
- Start with your largest blocks . . . 12.5″ x 9.5″ size. You will want to measure each of these to be sure they are the correct measurement. If not, you may need to trim or add an extra strip of white fabric. A "slight" shortage of the block you can "fudge" in the seam allowance, but anything more than 1/8″ you will need to add to the block. When adding strips to the block, cut them larger than you need, add to the block, then trim the block to the correct size.
- Once you get the large blocks to the correct size, place them on your design wall, randomly. You will be filling in around and between these blocks with your other smaller blocks. Remember that all the blocks do not need to be placed horizontally. There will be some blocks that will "read" equally well placed vertically. Use your sense of design to determine placement of the blocks.
- Take your next group of blocks . . . 6.5″ x 9.5″, and after checking their measurements and fixing any that need trimming or adding, begin to add these to your design wall. Remember, nothing you're doing at this stage is cast in stone. Once you get all your blocks on the design wall, you will be able to move things around. The 9.5″ side of these blocks will fit nicely against the 9.5″ side of the larger blocks. Be sure you have these medium sized blocks spaced throughout the quilt.
- Now, after measuring, and fixing if necessary, add your 3.5″ x 6.5″ blocks. Three of these vertically, or two of these horizontally, will fit along the 12.5″ side of the large block, and they will fit horizontally against the 6.5″ side of the medium size block. Shift and change things around until everything fits and you have a pleasing arrangement. I found that I needed lots of the small and medium size blocks and not so many of the largest size. But all of our quilts will be different, and you need to do what works best for your quilt and the blocks you've been sent.
- Study your layout. If you have any blocks made out of stretchy material, you might want to be sure they are in the middle of the quilt and not along the outside edges. The same goes for any blocks made of material that frays easily. By placing them in the interior of the quilt, they will be stabilized by the blocks surrounding them.
- Now you have the challenge of sewing your top together. Your blocks may not make straight rows across the quilt. I found that sometimes my blocks needed to be sewn together horizontally, and sometimes vertically. I found that it worked best to piece my quilt in sections. You may find this to be true for you, too. Take your time to study your layout. How does it make sense for you to do the piecing?
§ That numbering tag you see on each block? Please don't remove it during the process. See the second bullet point in the Piecers section. If tags do fall off, immediately replace them by stitching or pinning it back onto the block. If you wait until multiple tags fall off, you won't have a clue where they go.
§ The quilting (both topstitch and bobbin thread) must be completed in white thread (or a light neutral that matches the color of the majority of the blocks in the quilt).
§ Be creative with your quilting designs, and enhance the red X's and make them pop by quilting around and even up to BUT NOT OVER the red X's.
§ The backing fabric must be a white, preferably quilter's cotton or bleached muslin. Seams are okay, so it's not necessary to purchase 108″ wide fabric. it's not necessary to wash the fabric first – you can, but you don't have to as these quilts will never be washed.
§ Use a thin-loft, white batting – not puffy crafting batting, nor the off-white/ivory color. (This will help provide some consistency among the quilts AND conserve storage space.) Use whatever material or manufacturer you feel most comfortable using (100% cotton; 80/20 Cotton/Poly; All Poly; Wool; Warm & Natural; Quilters Dream Cotton, etc.)
§ Quilters differ on how "clean" the backs of their quilts need to be. Since these are going to be hung on walls the majority of their lives, follow your personal preference about burying the threads.
§ The quilts can be finished using a standard binding technique or a facing technique in white fabric.
§ The quilts must have a 4-inch rod sleeve attached to the back of the TOP edge of the quilt and must have a 1-inch gap between the side edge of the sleeve and the side edge of the quilt. Rod sleeves should be made from the same or similar color to the back of the quilt and facing.
I love to document and share your progress as you piece or quilt the top, so please send photos along the way as you can and will. I want to be able to use these images (with your permission, of course) for future publications, books, etc., so please send them directly to me instead of through Facebook because Facebook automagically reduces the size to a point that renders images not suitable for print. So, if you'd like your images to be part of the pool that I can choose from when publishing, here's how to do that:
§ Save each image as a JPEG (.jpg) file. Most cameras/phones already do that.
§ Name the image as follows: QUILT#_YOUR LAST NAME_IMAGE#.JPG (So, for example, when working on Quilt #5, MJ Kinman sent images using the following filenames: Quilt5_Kinman_1.jpg, Quilt5_Kinman_2.jpg).
Again, thank you for being such an important part of The 70273 Project and for making others aware of it in can they want to offer to piece or quilt. I can't wait to stand in the presence of these quilts.


text: reading through a few post it appears this weekend was very frustratingly busy for all. If only it were a rare occassion rather than a typical weekend. But it appears to be a little overwhelming this weekend. Maybe it is just me as we had a major twisted weekend. Cant post right now. But difficult child 16sd is gone. Anyhow, just an obervation and wanted to let you all know I feel all your pain and frustration. Now lets take a deep breathe and head into a new week. Sorry, trying to work on being a bit more positive.


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Flipkart is a leading e-commerce company which has the return policy if the customer is not satisfied with the goods. This is taken as an advantage by a youngster and duped Flipkart of Rs. 20 Lakh.
According to the reports Veera Swamy, 32 of Vanasthalipuram Hyderabad apparently duped the company by booking orders and returning the goods upon delivery. He would place the orders for valuable electronic items in the name of mother, father, wife, brothers and other known people in the neighbourhood. After the items were delivered, he would call up the call centre complaining that the goods delivered were of poor quality and take them away.
When the representative of the company came to pick back the goods he would keep the actual item received and put all the fake items in the box writing all the details on the box like item code, model number etc. Also, he had created the different fake mail ID's and bank payment through different accounts. Whenever the good is reached to the Flipkart the money would be returned to respective accounts.
Flipkart representatives of Hyderabad lodged a complaint in Vanastalipuram police station as " Veera Reddy is found to have made more than 200 purchases in different names in the last 20 months.
Thus, the company claimed to have incurred a huge loss of over Rs 20 lakh". Vanastalipuram police inspector P Pushpan Kumar who is investigating the case said that "We are verifying the contents of the complaint and the accused version".


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MelvitaROSE HIP OIL
- Category
- Product number
- 5504210004
Made from the seeds of the Chilean wild rose, this oil is rich in essential fatty acids and nourishes and regenerates even the most delicate, lifeless skin.
It helps to reduce stretch marks and softens the appearance of blemishes while making the complexion more radiant. Its soothing properties make it a good after-sun. Recommended for very dry skin, this oil is not suitable for skins with a tendency towards acne.
Melvita guarantee:
First cold-pressing organic oil.
Colorant and preservative-free.
- Note regarding this product.
- ・This 5% discount offer cannot be used together with any other coupons or discount campaign offers.


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I hope everyone is having a wonderful starting of the year 2013. I am so excited about this initiative to improve my quilting skills and make complete quilts this year.
I went ahead and created a flickr group for us: Boot Camp Sunday Flickr Group
If you want to join 2013 Quilting Boot Camp. Please join this group and introduce yourself.
This would be wonderful place to share your progress each week/month.
This is my first time hosting an event like this and I might have lot of learning to do myself. So, I am looking forward to your suggestions and ideas to improve your quilting boot camp experience. If you would like to see some particular techniques/patterns in this boot camp, please leave a comment below.
I have a plan laid out for the first quarter of the year.
January - Just borders
February - Strips & Coins
March - Tube quilting
April - Half Square Triangles and Snow balling
I wanted to added more information about the fabric choices for January month.
January - Just borders Fabric Selection
The theme for January is adding borders to squares, pre-printed panels or rectangles to make baby size to twin size quilt.
Fabric requirements options:
- Pre-printed panels: Work with pre-printed panels to add one or more borders to make baby quilts, table runners, table toppers, wall hanging etc.
- Pre-cuts: Make a baby/toddler size (40x50) or twin size(60x80) using Jelly Rolls/Rolie polies and charm packs.
- Large print yardage: Use a large print fabric as the center focus of the quilt/quilt block.
I am also thinking about opening up a bi-monthly link to track your progress.
Welcome all and please go ahead and sign up & introduce yourself in the flickr group: Boot Camp Sunday Flickr Group
Gear up for more information about January quilt in tomorrow's post.
Happy Quilting!


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Saint Thomas nabs Indiana executive as CEO
Saint Thomas Health Services today named Dr. Michael Schatzlein as president and CEO, ending a nearly year-long search for someone to lead the five-hospital system.
Schatzlein, 59, comes to Saint Thomas from Lutheran Health Network and Dupont Hospital in Fort Wayne, Ind., where he currently is president and CEO. His first day at Saint Thomas will be July 1.
"After a comprehensive, nationwide search for a new president, we feel fortunate to have secured someone with Dr. Schatzlein's experience and skills to lead Saint Thomas Health Services," Robert Henkel, president of health care operations for Saint Thomas' parent company, Ascension Health, said in a news release. "His background as a cardiac surgeon combined with his business development skill, evidenced by the growth of the Lutheran Health Network, will serve him well in Nashville."
Saint Thomas Health Services has been operating under an interim CEO since February 2009 when Jim Houser resigned. Two weeks earlier, Saint Thomas' physicians had delivered a vote of no confidence against Houser amid concerns that budget cuts were having on patient care.
Patrick Madden, former president of president of Sacred Heart Health System in Northwest Florida and market leader for Ascension Health's Gulf Coast/North Florida ministry, has been serving as interim CEO and assisting with the search for a permanent replacement.
According to a news release, Schatzlein has led the eight-facility Lutheran Health Network since 2007, having previously served as CEO of the network's St. Joseph and Dupont Hospitals and as chief operating officer of the network. The network serves a 23-county area in northeastern Indiana and northwestern Ohio.
"I've had the opportunity to meet with a number of physicians and associates of Saint Thomas Health Services," Schatzlein said. "It's clear that their devotion to the organization's mission, core values and quality patient care is representative of a truly remarkable organization. I look forward to joining them in their service."
Schatzlein received a bachelor's degree from Indiana University in 1970 and a medical degree from the Indiana University School of Medicine in 1974.


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Changes to the opening hours of enquiry offices at police stations across the H District policing area will come into effect on 1st December.
Ballymena and Coleraine stations will move to 12-hour opening, seven days a week. The offices will open between 8am and 8pm. Meanwhile, enquiry offices at Ballymoney, Ballycastle and Larne stations will provide an eight hour service on weekdays, 10am-6pm. On Saturdays and Sundays, the enquiry offices at Ballymoney, Ballycastle and Larne stations will open from 12 noon – 4pm.
Chief Superintendent Raymond Murray said: "The reduced opening hours reflect our efforts to deliver the necessary budget savings across the service. Station enquiry offices throughout Northern Ireland will similarly adjust opening hours, with the exception being Musgrave Street in Belfast and Strand Road, L/Derry. These stations will retain 24/7 opening hours.
"The reduction in opening hours should not mean a reduction in our service to the public. Police activities within stations will continue as normal and people can still contact police 24 hours a day/365 days a year on either the non-emergency number 101 or for emergencies on 999.
"The reality is that nearly all policing services are delivered outside of stations. Policing isn't about buildings. Rather, it is about officers working with the community, keeping them safe by preventing crime and detecting offenders.
PSNI Assistant Chief Constable Stephen Martin added his views on the revision to opening hours: "The public are increasingly engaging with the police in different ways – from online reporting of non-emergency and hate crime, to interacting with local police via social media. As a result we have found fewer people are visiting or using police stations.
Chief Superintendent Murray concluded: "The new hours may affect people who need to visit stations to produce driving documents or complete other business. We don't anticipate problems around this but I would ask for their patience at busy times."