text:
I am a lousy collector.
I started my stamp collection as an adult thanks to Africa, which popped up into my life on a cold winter day. I fell in love with R, a Professeur agrégé de Sciences Naturelles who was to marry a natural scientist who did not know whom she loved best. Her husband-to-be or his best friend B, another Professeur agrégé de Sciences Naturelles.
People ! I've discovered a new Species !
The two guys were King One and King Two of the University of Paris. Too bad for her that the Law of Man (contrary to the Law of Nature ?) did not allow her to marry the two of them at the same time. Since each of them was only the half of the perfect whole… she kept being torn apart. I love you. No, I am not sure I love you. Her poor fiancé nearly knocked out his head with a big martello; a natural guy facing a truly natural craziness.
On a December day, I got involved in a traffic accident. My cute face swelled like a big polychromatic balloon. I looked like a huge zipper : some surgeon designed his next Spring Collection on my face. "Stay calm. Don't laugh ! Otherwise, your wounds will open up." I must say, there was no reason for a good laugh as I look in the mirror. The sexy girl? Gone. Instead of the stunning little creature I used to be, I saw an awful broom. On the broom, an ugly witch.
Hospital visiting hours. The undecided lady, who was my roommate, her boyfriend R, his best friend B, their acoustic guitars and some other students of the Faculté des Sciences came to admire me wearing the next Spring Collection on my face. They played guitar, they sang, breaking the silence of the hospital for some wonderful time. They told jokes to make me laugh. I tried not to. But it was hard. So many sensations for only one person : me. Pain. Joy. Cheerful moments of life.
The nurses showed up and sent all the Lebenskuenstler to hell. 'Silence ! Hospital !" They disappeared all at the same time like a bunch of birds.
I don't drink, I don't smoke
Three days later, Prince Charming opened the door of my hospital room, a big bouquet of fleurs in his hands. R had fallen in love with me although I was looking … outrageous. He forgot about Lady Undecided. We married and he went to Africa. I started my stamp collection.
African stamps are very colorful and beautiful. I did not throw away the stamps which came along with the letters sent from Africa. Doing so would have meant that I put the paradise into the garbage. But after only three years, my sister became the curator of my stamp collection.
My best looking collection was the one with the bottles of alcoholic beverages. Rum, Gin, Cognac, Armagnac, Whiskey, Cointreau, Vodka, Ricard, Pastis, Grand Marnier, Martini blanc, Martini rouge, Pineau des Charentes, etc. The mini bottles as well as the big bottles were well represented on the shelves of my mini bar. I had about 80 big bottles and lots of tiny ones, the kind you get on airplanes. All the shapes, the colors of the liquids, the labels, each of them had a language of its own, teasing my imagination and taking me to many places of the world. It made me happy just by looking at them.
I used to cook for friends. It was no a big deal for me to cook for five or fifty people. It was such a pleasure to see them help themselves at my own bar, mixing cocktails. They had more choices than in most of bars or restaurants in town. And everything was for free ! They spent long hours having food, drinking and chatting. It was really nice and never difficult for them to make me presents! A bottle of alcohol was always welcome.
Friends were surprised to hear about my collection of alcoholic beverages, since I drink tap water on a daily basis. Otherwise, fresh fruit juices, milk, teas, soja milk, Coke and Ginger ale detain big shares. After 10 years busy collecting beverages I had to move. So I got rid of all the beverages.
The following collection was … breathtaking :
Long ago, I felt for a guy. He felt for me, too. Then our paths departed…. Many years back our paths crossed again. At first it was a great wiedersehen. Then he thought he was in love with me. In only two years, he wrote 700 (seven hundred) letters to me ! A whole heap of letters. Despite of his beautiful handwriting, I started to hate receiving his letters. My mailbox was full of his letters. Some days, 6 letters at a time, heavy as lead, fell onto my feet. I begged him : Please, don't write so many letters. One letter a month would be fine. Don't spend all your precious time writing long letters (some of them were 14 (!) pages long in a small and beautiful handwriting).
He did not want to hear. I could not stand him any longer. The phony relationship stopped unsmoothly. He hates me now.
I am not an autograph hunter. Nevertheless, I have two autographs that I am very proud of :
– Konrad Zuse
– Theodore Monod
Since I am not good at collecting things, don't look for money bills in my pockets. I have many pockets. Unfortunately, there is no cash inside. Either I gave away a stack of bills, or I lost some, or I bought futile things just to be happy a brief moment.
Tags: beverages, collectionneuse, emergency, konrad zuse, sciences, theodore monod


text:
You will be contacted soon after placing your order to arrange delivery
A high quality garden bistro set made from solid FSC Acacia, a smooth nartural hardwood with very few knots and renowned for its extreme hardness and resilience to weathering. A round folding table complete with two folding chairs with cushions. Perfect for relaxing on a sunny day, then easy to fold away and store.
Table Size: H72 x 60cm Diameter. Chair Size: H78 x W38 x D34cm Colour: Grey
Average Rating:
(2 reviews)
"Already assembled ready to go!!"
Reviewed Monday, 7 August 2017
"Much better than we expected for the price. Just perfect for the job. Light but strong for it's size."
Reviewed Saturday, 12 September 2015

subset: commoncrawl


text:
Reuters Staff
1 Min Read
May 23 (Reuters) - Twitter Inc:
* Twitter says stockholders did not approve stockholder proposal regarding report on users owning Twitter platform in stockholder meeting - sec filing Source text - bit.ly/2qT4n5d Further company coverage:
All quotes delayed a minimum of 15 minutes. See here for a complete list of exchanges and delays.
© 2018 Reuters. All Rights Reserved.


text:
That's right. Nowadays, everything has to be pumpkin spiced!
So we figured, why not share a little post about the beauty of fall?
Every autumn in the New England states, October brought with it chilly weather, pumpkins, apple picking and spectacular fall foliage.
It brought with it hot mulled apple cider, keeping your hands warm on a crisp day, the first day you pull out your gloves and can see your breath mist.
October brought with it a sense of warmth and harvest and sweetness.
I enjoy my swampy Houston home, but man, there are times when I truly miss the spectacle of autumn.
Jessi and I grew up in the frigid north, and she, too, has that irreplaceable sense of nostalgia for all things fall when she pines for Ohio.
Here are a few fond memories I have of my time spent in Massachusetts and Colorado, and all the joys of pumpkin spiced weather.
Fall Foliage: Hiking in Colorado
Boulder County has tons of really great hiking paths, and in the fall, the wooden paths and mountain trails are constantly beckoning.
Fall Foliage: School-time Activities
For me, September and October bring strong memories of school buses and new backpacks. Or, in the case of the pictures below, my time spent in graduate school in Boulder, Colorado. By then, I'd traded my school bus for a Toyota, and my backpack for a computer bag and piles of academic papers.
Can you just feel the mountain breeze in these pictures?
For one of my graduate classes in zoology and field studies, I got to hang out in the Colorado wilderness and make a survey of the number of bird species I could count. It was a great excuse to get outside in the fresh Colorado mornings, sitting by the many ponds and open space land in the Boulder area to count avian fauna. Talk about experiential education!
Plus, it was really stunningly pretty!
The sunlight! The stark red leaves! Cue the angelic chorus!
Back in the sunny Pioneer Valley in Western Massachusetts, fall kind of explodes with color, and leaf-peepers come from all around to bask in the rainbow.
I also spent my book-learning years here, at the University of Massachusetts. Good old school memories, walking the old campus lawns.
The Great Pumpkin
Finally, I can't have a post about pumpkin spice without…no, not Starbucks…but a pumpkin.
Albeit, Boston style. This is how crazy my hometown gets about the Boston Red Sox.
You might say we're out of our…gourds?
Got any good stories about Autumn-slash-Fall? What's it like in the Southern Hemisphere? Is the changing of the leaves a big deal where you live? We'd love to hear from you!


text:
|Home | About | Journals | Submit | Contact Us | Français
The metabolism of xenobiotics is complex and involves multiple steps and multiple enzymes. Genetic variation in the genes encoding these enzymes as well as the level of exposure to the substrates of these enzymes could alter metabolism and clearance of potential carcinogens and thus alter cancer susceptibility. This study examined interaction effect between smoking and two single nucleotide polymorphisms (SNPs)—CYP1A1 c.1384A>G (p.Ile462Val) and EPHX1 c.337T>C (p.Tyr113His)—in modulating colorectal cancer (CRC) risk. The SNPs were selected a priori based on functional significance.
In a case-only analysis, unconditional logistic regression was used to examine the associations between smoking and each SNP and between the two SNPs in 786 patients with nonfamilial CRC.
There was significant multiplicative interaction for CRC risk between smoking and EPHX1 c.337T>C (odds ratio [OR] = 1.37, 95% confidence interval [CI] = 1.03–1.81, P = 0.03), particularly among smokers with a history of greater than 20 pack-years of smoking (OR = 1.52, 95% CI = 1.07–2.16, P = 0.02). In addition, there was gene-gene interaction between EPHX1 c.337T>C and CYP1A1 c.1384A>G (OR = 1.61, 95% CI = 1.02–2.55, P = 0.04).
Smokers with any variant allele of EPHX1 were at increased risk for CRC, as were individuals with any variant allele of CYP1A1 together with any variant allele of EPHX1. Thus, the study of gene-environment and gene-gene interactions may help to identify high-risk subgroups that can be targeted for intensive smoking cessation and CRC screening interventions.
Colorectal cancer (CRC) is the third most common cancer in both men and women, representing 10% of all cancers in men and women [1]. It is also the second most frequent cause of cancer mortality, accounting for 9% of all deaths from cancer in men and women. An estimated 146,970 incident cases of CRC and 49,920 deaths due to CRC were expected in the United States in 2009 [1]. Risk for CRC is influenced by both environmental and genetic factors. Smoking is a putative risk factor for many cancers, and mounting evidence indicates that smoking is a risk factor for CRC [2]. Genetic risk factors for CRC include the highly penetrant but rare mutations seen in familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer syndrome (HNPCC or Lynch syndrome), which demonstrate a Mendelian inheritance and account for ~5% of CRC cases [3]. There is evidence that other, more common, low-penetrance gene mutations may also be associated with risk for CRC (reviewed in [4]).
Cigarette smoking is a widespread source of exposure to carcinogens like polycyclic aromatic hydrocarbons (PAHs) and nitrosamines. These potentially carcinogenic substances are metabolized by many different metabolic enzymes that vary in their expression and activity levels due to polymorphisms in the genes encoding them. These enzymatic variations can result in differences in the metabolism and clearance of carcinogens and therefore modify cancer risk.
The enzyme that principally metabolizes PAHs is encoded by the CYP1A1 gene. Two single nucleotide polymorphisms (SNPs) in CYP1A1 have frequently been examined for their relationship to cancer susceptibility: a T>C polymorphism in the 3′-untranslated region, which creates an MspI restriction site, and a c.1384A>G polymorphism that results in an amino acid change from isoleucine to valine (p.Ile462Val). The process by which PAHs are metabolized involves a phase I activation reaction in which highly reactive intermediates with mutagenic potential are generated [5,6]. The CYP1A1 c.1384A>G SNP is associated with increased activity of the enzyme [7] and thus increased activation and carcinogenic potential of PAHs and the associated activated metabolites.
PAHs are also substrates for the EPHX1-encoded enzyme microsomal epoxide hydrolase, which hydrolyzes epoxides; the metabolic process can result in both detoxified or more toxic product [8]. Variations in EPHX1, such as non-synonymous SNPs c.337T>C (p.Tyr113His) and c.416A>G (p.His139Arg), influence enzyme activity and may thus modulate the risk of PAH-mediated CRC, especially in smokers. Specifically, the EPHX1 c.337T>C variant allele is associated with reduced enzyme activity [8].
Earlier, in a retrospective study on a cohort of individuals with Lynch syndrome (individuals with a genetic predisposition for CRC due to an inherited pathogenic mutation in one of the DNA mismatch repair genes), we reported on the effect of polymorphisms in certain candidate xenobiotic metabolizing genes on risk for CRC [9]. We found that the CYP1A1 c.1384A>G and MspI variant alleles were associated with an earlier age at onset of CRC, and the data were suggestive of an interaction between CYP1A1 c.1384A>G and EPHX1 c.337T>C SNPs in modulating age-associated CRC risk (P for interaction term = 0.036; Wald χ2 P = 0.044).
Since the PAHs present in cigarette smoke are metabolized by polymorphic enzymes it is reasonable to assume that the effect of genetic background on CRC risk could be modified by smoking. However, although gene-gene interaction was explored in our previous study on Lynch syndrome, the sample size was too small (smoking and genotype information were available for only 167 individuals) for examination of possible gene-environment interaction between smoking and the metabolic gene SNPs that were found to be associated with CRC risk. Therefore, in the current study, we examined a series of 786 nonfamilial CRC cases to test the hypothesis that smoking interacts with the polymorphic CYP1A1 c.1384A>G or EPHX1 c.337T>C in influencing risk for CRC. We also used this sample of sporadic CRC cases to validate the gene-gene interactions observed between CYP1A1 c.1384A>G and EPHX1 c.337T>C in our previous study and to test the hypothesis that individuals with variant alleles of both SNPs are at significantly higher risk for CRC.
The study population consisted of a series of 794 patients with histopathologically confirmed CRC enrolled as participants in TexGen at The University of Texas M. D. Anderson Cancer Center from April 2002 to July 2007. The TexGen research project is an ongoing project that collects and stores biological material (blood and tissue) for future genetic and medical research at the Texas Medical Center. TexGen enrolled all new patients in the Gastrointestinal, Genitourinary, and Urology Centers at M. D. Anderson Cancer Center who were age 18 years or older and consented to the study. We studied all patients from the TexGen series with non-syndromic CRC (any patients with known hereditary or familial CRC were excluded). Blood samples were collected in EDTA tubes at the same time that the patient underwent venipuncture for other tests. The samples were processed on the same day or the next day and stored at −80°C. The process for DNA extraction and purification involved spinning the blood samples at 2800 rpm for 10 min, then 1–4 ml of plasma was separated, leaving the buffy coat for DNA extraction. DNA was extracted on an Autopure LS automated DNA purification instrument (Gentra Systems Inc., Minneapolis, MN) according to the manufacturer's instructions. The steps for purification of DNA included lysis of red blood cells and nucleated cells, protein precipitation to pellet cellular proteins, DNA recovery using 100% isopropanol, washing of the DNA pellet with 70% isopropanol, and DNA hydration before storage.
The demographic and epidemiological data for the patients in this study were obtained from the Patient History Database questionnaire. This questionnaire is a medical intake form that all newly registered patients are required to complete at presentation to M. D. Anderson Cancer Center. The form has been in use since December 1999, and 93% of all newly registered patients complete the questionnaire. The form is a template that the clinician uses to guide the primary medical evaluation, and besides eliciting smoking history, it asks for core risk factor, family history, demographic, and quality-of-life information that the patient self-reports. Certified clinical coding specialists abstract the data and enter them into a web-based Oracle database. Quality control checks are performed at regular intervals. The Institutional Review Board approved the use of TexGen samples and data for this study.
Participants were characterized at study enrollment as "never-smokers" if they had smoked fewer than 100 cigarettes in their lifetime and as "ever-smokers" if they had smoked at least 100 cigarettes. The ever-smokers were further divided into "former smokers" and "current smokers". Former smokers were defined as subjects who had quit smoking at least 1 year before their cancer diagnosis, and current smokers were defined as those who were smoking within 1 year before their cancer diagnosis. Smoking dose was calculated in pack-years by multiplying the number of packs of cigarettes smoked per day by the number of years of smoking. On merging the TexGen and Patient History Database data files, we excluded 6 individuals who had incomplete smoking data, so that our final study sample consisted of 794 individuals.
Genotyping for EPHX1 c.337T>C polymorphism was performed with the Taqman assay using protocols described by the manufacturer (Applied Biosystems, Foster City, CA). Primer and probe sequences were obtained from the National Cancer Institute's SNP500Cancer database (http://snp500cancer.nci.nih.gov/). The dual-384-well GeneAmp PCR system 9700 (Applied Biosystems) was used for polymerase chain reactions (5 μl) that included 5 ng of sample DNA, 2.5μl of 2 X Taqman genotyping master mix (Applied Biosystems), and 900 nM for each primer and 200 nM for each probe. The polymerase chain reaction conditions were 95°C for 10 min, followed by 50 cycles of 92°C for 30 s and 60°C for 1 min. The reacted plates were then read using the ABI Prism 7900HT sequence detection system, and genotypes were automatically called by the built-in software. Positive and negative controls were used in each genotyping assay, and more than 5% of samples were randomly selected and run in duplicates with 100% concordant results.
The CYP1A1 c.1384A>G polymorphism was not amenable to genotyping on the Taqman platform, so genotyping was performed on a pyrosequencer (PSQ 96 System; Biotage, Inc.) using the method described previously [9,10]. For quality control, 5% of the samples were run as duplicates in the pyrosequencing reactions with no conflicting results.
We estimated the genotype frequencies for CYP1A1 c.1384A>G and EPHX1 C.337T>C and tested each SNP for Hardy-Weinberg equilibrium. A case-only design was used to examine the interactions between smoking and each of these SNPs and also gene-gene interaction between these two SNPs.
In a case-only analysis, it has been shown that the odds ratio (OR) for the association between the environmental exposure and the gene is a function of the OR for the environmental factor alone, the genotype alone, and their joint effects in a regular case-control study [11]. Khoury and Flanders [12] have elaborated that the case-only OR can be interpreted as the multiplicative interaction between gene and environment under the assumption that the gene and environment are independent of each other in risk for disease. To address the independence assumption between the genes and smoking in our study, it can be stated that individuals do not routinely know their genetic status for CYP1A1 or EPHX1 SNPs and that neither of these genes is known to be associated with smoking behavior, so it is unlikely that an individual's genotype influences whether or not he or she smokes. Another method to determine independence between exposures is to examine their relationship in a sample of controls from the same base population as the cases, as suggested by Piegorsch et al. [11]. A lack of association between the exposures among the controls would indicate that the exposures are independent. Therefore, to determine whether smoking and genotypes for each of the SNPs were independent, we examined their relationship in a sample of 722 controls from the same base population as the cases (these were controls for a lung cancer study at M. D. Anderson Cancer Center for whom genotyping data for the two SNPs were available [13]), and we found no differences in genotype frequencies between smokers and nonsmokers for either SNP (χ2 P > 0.05). Therefore, we made the assumption that the gene and environmental exposures were independent and our interaction estimates were valid. Similarly, in testing for gene-gene interaction, linkage disequilibrium may cause nonindependence between the genes, which can invalidate a case-only design to measure gene-gene interaction [14]. Since genes on different chromosomes are unlikely to be correlated and the genes we tested are located on separate chromosomes (CYP1A1 on chromosome 15 and EPHX1 on chromosome 1), the independence assumption for these two SNPs was not violated.
Unconditional logistic regression was used to estimate the case-only ORs and 95% confidence intervals (CIs) to assess the interaction effect of smoking and each of the SNPs and to determine the influence of interaction between the two SNPs on CRC risk. Data for the CYP1A1 SNP were dichotomized by combining the heterozygous and homozygous variant genotypes (AG+GG) because of the low frequency of the GG genotype. The EPHX1 SNP c.337T>C was examined in both an additive and a codominant model. The wild-type genotypes formed the reference group. Gender, age and ethnicity were included as covariates in the regression model as potential confounders. The interaction effects were also examined by cancer stage (localized vs. distant) and site (colon vs. rectal). Lastly, in stratified analyses, the gene-gene interaction was analyzed within smoker/non-smoker and gender subgroups. All statistical analyses were performed using STATA 8.0 statistical software (StataCorp LP, College Station, TX).
Of the 794 participants, we had complete genotyping data for 786. Genotyping of the remaining 8 samples failed for one or both SNPs, and these samples were therefore dropped from the analysis.
Participant characteristics and genotype frequencies are presented in Table 1. The study population was mostly non-Hispanic White (80%), and there were more men (59%) than women. Smokers constituted 47.2% of the population, and among the smokers, about half (50.4%) had a history of greater than 20 pack-years of smoking. Both of the SNPs were in Hardy-Weinberg equilibrium (CYP1A1 c.1384A>G, χ2 P = 0.73; EPHX1 c.337T>C, χ2 P = 0.36).
Information about gene-environment and gene-gene interactions and CRC risk is presented in Table 2. The case-only OR comparing the CRC risk between ever-smokers with the variant EPHX1 c.337T>C genotypes and never-smokers with the homozygous wild-type genotype was statistically significant (OR = 1.37, 95% CI = 1.03–1.81, P = 0.03), suggesting the presence of an interaction between smoking and EPHX1 (Table 2). Further, the interaction effect between EPHX1 c.337T>C and greater than 20 pack-years of smoking was also significant (OR = 1.52, 95% CI = 1.07–2.16, P = 0.02), suggesting that the EPHX1 c.337T>C variant genotypes influence susceptibility for CRC particularly among heavy smokers (>20 pack years). There was no evidence of a similar interaction between smoking and CYP1A1 c.1384A>G (OR = 0.73, 95% CI = 0.46–1.14, P = 0.17).
The OR for gene-gene interaction between the two SNPs was significant for individuals with any variant allele of CYP1A1 c.1384A>G and any variant allele of EPHX1 c.337T>C (OR = 1.61, 95% CI = 1.02–2.55, P = 0.04) and more so for individuals with the EPHX1 homozygous variant genotype (OR = 2.96, 95% CI = 1.57–5.57, P = 0.001) compared to individuals with the homozygous wild-type genotypes of the two SNPs (referent), suggesting the presence of an interaction between these two SNPs. Adjusting for gender, age and ethnicity did not significantly alter any of the main effect estimates (results not shown); therefore, the unadjusted estimates are presented (Table 2).
Although the power was limited for subgroup analyses, on stratification by smoking status, the OR for interaction effect was statistically significant for the CYP1A1 any variant and EPHX1 homozygous variant genotype (CC) in both never-smokers (OR = 2.67, 95% CI = 1.16–6.15, P = 0.02) and ever-smokers (OR = 3.59, 95% CI = 1.33–9.65, P = 0.01), but the OR was much higher in ever-smokers (Table 3). The OR for interaction effect did not differ by tumor stage or site. Similarly, there was no interaction effect between gender and either of the SNPs. However, in subgroup analysis by gender, a gene-gene interaction effect was seen in males but not in females (Table 4).
In this case-only analysis, there was evidence of departure from multiplicativity indicating a gene-environment interaction between EPHX1 c.337T>C and smoking, particularly in smokers with a history of greater than 20 pack-years of smoking. In addition, there was a gene-gene interaction between CYP1A1 c.1384A>G and EPHX1 c.337T>C. Therefore, our results suggest that (1) the impact of cigarette smoking on CRC risk is synergistically increased among individuals who carry a variant allele of EPHX1 c.337T>C and (2) individuals who carry variant alleles of both CYP1A1 c.1384A>G and EPHX1 c.337T>C are more susceptible to CRC. Furthermore, in an analysis stratified by smoking status, we found that the OR for gene-gene interaction effect was statistically significant for the EPHX1 homozygous variant genotype (CC) in both never-smokers and ever-smokers but that the OR was higher in ever-smokers. Similarly, the OR for gene-gene interaction was significant in males but not in females, although overall, there was no significant interaction between gender and either of the SNPs. These results were based on a limited number of patients, but they suggest that compared with nonsmokers with wild-type alleles for both SNPS, smokers with variant alleles of CYP1A1 c.1384A>G and smokers with the homozygous variant genotype for EPHX1 c.337T>C are at significantly increased risk for CRC and the gene-gene interaction effect may be gender specific, as it was evident only in males.
In our previous study on individuals with Lynch syndrome, we found evidence for multiplicative interaction between CYP1A1 c.1384A>G and EPHX1 c.337T>C (P for interaction term = 0.036; Wald χ2 P = 0.044) with a greater than multiplicative hazard ratio for the combined effect of having a variant allele of each of these SNPs (hazard ratio, 3.09, 95% CI, 1.58–6.04; P = 0.001). The purpose of the present study was to see if these findings were replicable in cases of nonsyndromic CRC. Even though the study designs used to obtain the interaction estimates were different (retrospective cohort versus case-only design), the results from both studies were statistically significant.
Most of the association studies for EPHX1 and smoking in colorectal carcinogenesis have examined colorectal adenoma as the outcome [15–18]. Of three studies with CRC as the outcome one reported an increased frequency of the c.337C variant allele in CRC cases compared to controls [19], one found a reduced CRC risk associated with the c.337C allele [20] and one large case-control study found no association [21]. Similarly, there have been conflicting results for the interaction effect between smoking and EPHX1. Ulrich et al. [18] found that the variant EPHX1 c.337C allele increased adenoma risk among smokers and the risk was highest among those with greater than 25 pack-years of smoking (similar to our findings for CRC risk), whereas other studies reported reduced risk associated with the low activity c.337C allele in the presence of smoking [15–17]. Further validation of the influence of EPHX1 on risk of CRC in the presence of smoking may therefore be warranted.
Few studies have evaluated the association between CYP1A1 and CRC, though CYP1A1 has been extensively evaluated in other smoking-related cancers (reviewed in [22]). Slattery et al. examined the association between CYP1A1 c.1384A>G and smoking in risk of CRC in 1026 cases and 1185 controls and found that the individuals at highest risk for CRC were men who were currently smoking and had any CYP1A1 variant allele. The authors concluded that the impact of smoking on CRC risk may depend on CYP1A1 genotype [23]. Fan et al. used a case-only study similar to our own study to determine the interactions between certain polymorphisms in metabolic enzymes and smoking in 207 Chinese patients with CRC and found a significant gene-gene interaction between CYP1B1 1294G and SULT1A1 638A alleles (OR 2.68, 95% CI = 1.16–6.26) and gene-environment interaction between CYP1B1 1294G and smoking (OR 2.62, 95% CI = 1.01–6.72) [24]. However, the results of their study and our study cannot be compared since the polymorphisms examined in the two studies were different.
PAHs in cigarette smoke are substrates for both CYP1A1 and EPHX1, and these two enzymes act sequentially to metabolize PAHs. Therefore, a biological interaction effect may exist between CYP1A1 and EPHX1. First, CYP1A1 converts benzo(a)pyrene to the active benzo(a)pyrene 7,8 epoxide. This is then hydrated by EPHX1 to a transhydrodiol derivative, benzo(a)pyrene 7,8 diol, a product that is less toxic [16]. However, the diol derivative is also a primary substrate for CYP enzymes that oxidize it further to benzo(a)pyrene 7,8 dihydrodiol 9,10 epoxide (BPDE), which is highly reactive and capable of forming DNA adducts. Therefore, these genes may interact to play a more complex role in cancer susceptibility.
The case-only approach was appropriate for our study since it was used to validate a priori findings of an interaction effect between two SNPs. However, a case-only study does have the disadvantage of not allowing evaluation of the independent effect of either of the exposures, smoking alone or the CYP1A1 and EPHX1 genotypes alone, but only allowing evaluation of their interactions. It also does not allow assessment for departures from joint additive effects (can only test departures from joint multiplicative effects) of the exposure and genotype or the genotypes with each other. However, the case-only design is efficient (smaller sample size required to assess interaction than in a case-control design) [14] and offers less potential for misclassification of exposures.
Though both CYP1A1 c.1384A>G and EPHX1 c.337T>C are nonsynonymous SNPs and therefore likely have functional consequences, we queried two programs (PolyPhen [http://genetics.bwh.harvard.edu/pph/] and SIFT [http://blocks.fhcrc.org/sift/SIFT.html]) that predict the impact of an amino acid substitution on protein function to assess whether these SNPs are potentially deleterious. Polyphen classified CYP1A1 c.1384A>G as "benign," and SIFT classified it as "tolerated." EPHX1 c.337T>C, on the other hand was classified as "possibly damaging" by Polyphen and "intolerant" by SIFT. The EPHX1 c.337T>C SNP may therefore be important to follow up on in functional studies in CRC.
Our study was underpowered for subgroup analysis by race/ethnicity due to the low frequency of the CYP1A1 variant genotype. The OR for interaction between CYP1A1 c.1384A>G and EPXH1 c.337T>C (homozygous variant) lost significance when we analyzed the non-Hispanic Whites alone (OR(EPHX1:CC genotype) = 2.2, 95% CI = 0.87–5.56, P = 0.09). However, evidence for interaction between EPHX1 c.337T>C and smoking remained significant when the analysis was limited to non-Hispanic whites—that is, among whites, ever-smokers with one or two copies of the EPHX1 variant c.337C allele had OR = 1.4 (95% CI = 1.05–1.97, P = 0.02) compared to never-smokers with the TT genotype. Overall, including ethnicity as a covariate while testing for interaction, did not alter the main effect estimates. Analyzing interaction effects in a larger sample of each ethnic subgroup may be required to validate these findings more globally.
Our finding of evidence for a gene-gene interaction between CYP1A1 c.1384A>G and EPHX1 c.337T>C in risk for sporadic CRC is especially meaningful, since to our knowledge this interaction has not previously been described and since this finding validates a similar interaction seen in our previously reported study [9] in a different study population. Future plans for these findings would include evaluating the gene-gene and gene-environment relationship as predictors of CRC recurrence and survival. In conclusion, while low penetrance genes like CYP1A1 and EPHX1 may raise the cancer risk only slightly independently, in combination they may greatly increase cancer susceptibility. Therefore, individuals who have multiple genetic susceptibility alleles and are smokers may be a subgroup that could be targeted for more intensive interventions than is recommended for the general population.
Grant support: This study was supported in part byNIH Cancer Center Support grant CA16672, and National Cancer Institute grants CA57730, CA070759 and CA133996.
We thank Dr. Kelly Merriman and Elizabeth Thompson for their assistance in providing the TexGen data and samples.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
CULTURAL EXCHANGE SCHOLARSHIPS PROGRAM FOR YEAR 2016 announced by Government of Pakistan Ministry of Inter Provincial Coordination (IPC Division) through NTS test. The Ministry of Inter Provincial Coordination (IPC) has assigned the task of conducting the GRE (Local) Subject wise test to the National Testing Service (NTS) for the subject scholarships.
Eligibility Criteria for CULTURAL EXCHANGE SCHOLARSHIPS PROGRAM:
The candidates must have completed Sixteen Years Education that is MA / MSc OR must hold four (04) years B.Sc. (Hons) Agriculture, B.Sc. (Engg), BCS (Hons), MBBS in the relevant field.
Other Terms and Conditions:
- Maximum age limit is 35 years on the closing date of applications.
- Applicants having more than one second division in their academic career are not eligible to apply.
- Attested copies of each supporting document (Matric to onward) including domicile certificate, must be sent with the application. The professional degree holders B.Sc. Engg / MBBS, B.Sc. (Hons) Agriculture should submit detailed marks certificate of each year
- The scholarships are awarded on merit determined on the basis of NTS Test score, observing Provincial/ Regional quota
- The candidates will have to take Language Course of the respective country (if applicable).
- Students awaiting results are not eligible to apply.
How to Apply:
- Application forms and online deposit slips are available on our website www.nts.org.pk
- Applications must be received by NTS not later than 11-11-2015.
- NTS will not be responsible for late receipt of applications sent through post.
- Please deposit online through the prescribed deposit slip in the online branches of ABL, UBL, MCB or HBL. Application form and online deposit slip are available on NTS website.
- Candidates are required to send their applications to NTS Headquarters, Islamabad on prescribed forms along with online deposit slip (original).
- Candidate can also use printout of webpage containing their test related information as roll no. slip.
- Deposited amount is non-refundable and non-transferable.
- Applications submitted by hand will not be entertained.
Test Schedule:
To Register Online:
Last Date for Submission of Applications: Wednesday, 11th November, 2015
Test Date: Sunday, 29th November, 2015
- Applications are invited for study abroad under the Cultural Exchange Scholarships Programme for the year 2016for Master's and Ph.D. studies in various subjects. The scholarships are expected from China, Turkey, Romania, Czech Republic, Slovak Republic, Mexico, Greece, Russia, South Korea and Italy. These scholarships are Fully Funded as the donor countries provide tuition fee, accommodation and monthly living allowance, which varies from country to country.
- Application submitted by hand will not be entertained.
Please send your applications on the address given below:
National Testing Service (NTS) Pakistan
1-E, Street No. 46, I-8/2, Islamabad
Website: http://www.nts.org.pk
Help Line: +92-51-844-444-1
Dogar Brothers utterly provide Best Stuff for your good preparation. Just catch-up a Book of Dogar Brother's to get selected through your exams. Our mission is "Contributing to the success of widest possible audience through availability of learning resources at affordable price".
Keep connected with dogar.com.pk Facebook, Twitter, Pinterest and Google Plus to get latest updates.


text:
Property Location
Fragrance Hotel - Selegie is in the heart of Singapore, walking distance from Sim Lim Square and Nanyang Academy of Fine Arts. This hotel is close to Chinatown Heritage Center and National Orchid Garden.
Make yourself at home in one of the 95 air-conditioned rooms featuring LCD televisions. Complimentary wireless Internet access keeps you connected, and cable programming is available for your entertainment. Private bathrooms with showers feature complimentary toiletries and hair dryers. Conveniences include phones, as well as coffee/tea makers and complimentary bottled water.
Take advantage of recreation opportunities such as an outdoor pool, or other amenities including complimentary wireless Internet access and tour/ticket assistance.
Enjoy a satisfying meal at a restaurant serving guests of Fragrance Hotel - Selegie.
Business, Other Amenities
Featured amenities include a business center, dry cleaning/laundry services, and a 24-hour front desk. Free self parking is available onsite.


text:
Build Guide by Mintor
This build has been archived and is for historical display only.
PLEASE NOTE: This build has been archived by the author. They are no longer supporting nor updating this build and it may have become outdated. As such, voting and commenting have been disabled and it no longer appears in regular search results.
We recommend you take a look at this author's other builds.
Not Updated For Current Season
This guide has not yet been updated for the current season. Please keep this in mind while reading. You can see the most recently updated guides on the browse guides page.
Thank You!
Your votes and comments encourage our guide authors to continue
creating helpful guides for the League of Legends community.
Dr. Mundo Build
Top Lane
Ability Sequence
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Sourse of idea
Full description from:
Your text to link here...
So main idea isn't mine... I just made this build, because I use other masteries and runes... And wanted to show this to my friends...
About CDR
At level 13th you have maximum CDR 40%
Remember the maximum cap is 40% of CDR - YOU CAN'T GET MORE ! ! !
I use CDR per level because I don't have flat CDR :(
Flat CDR is much more better!


text:
The Modern Bunkbed
January 19, 2008
by Don VanPelt
Is there any better, more efficient way to use the space you have in your children's room than by using bunkbeds? Today's modern bunkbeds are contemporary, modular, sculptural creations that have taken an old unsafe concept (i.e., your father's bunk beds) and transformed the notion into something that is completely aesthetic and safe for all but the very youngest of children. Safety should be, of course, the primary concern when buying bunk beds; today, many bunk beds offer safety features to prevent your children from tumbling from the upper bunk. Improved safety ladders also offer parents additional peace of mind.
It's not just about safety, though. Today's bunk beds have come a long way from the clunky monstrosities that your parents grew up with. They have become very modern and useful, with all sorts of nooks and crannies for storage. Just think of the space you could save if all of your child's things could be stored in one area! All that is possible with today's bunk beds. And, as your child ages, the extra space can be used for bed linens or extra clothes Some bunk beds even convert to a student desk. It's a Transformer of the very best kind—how have you done without a bunk bed for so long?
And today's bunk beds are available in such a vast array of hardwoods, laminates, and even eye-pleasing metals. Chances are, whether your tastes run to Colonial, Provincial, contemporary, or your own unique style, there is a bunk bed for you. Seeing really is believing. Some models also come with an additional option of a trundle bed, making the prospect of an unexpected guest not such a big deal after all.
Forget what you thought you knew about bunk beds. Take a moment and visit your local bunk bed dealer (either online or in person). You and your child will appreciate the benefits a bunk bed can bring. Once your child's bedroom is opened up, you will appreciate the extra space; and he will appreciate the "cool" factor a bunk bed brings. Open up your child's room—and your own horizons, and consider purchasing a bunk bed today!
Don VanPelt is a writer for Bunk Beds Central who has published many articles about various types of bunk beds including futon bunk beds. Read his comments and recommendations for the best places to buy bunkbeds.


text:
Looking for ways to help baby or toddler sleep? We offer custom child sleep solutions that will get your family sleeping through the night in no time. Strong Little Sleepers offers a variety of baby and toddler sleep packages. If you need assistance determining which package would be the best fit, please contact us and we will assist you.
Please contact us for consultation availability.
Child Sleep Package #1 – Online Courses through Strong Sleep School:
Learn how to create healthy sleep habits for your child! Put a sleep plan in place and make changes in your own time. Our online courses are perfect for families who feel overwhelmed by all of the conflicting information that's out there about baby sleep and want someone to break it all down for them. You'll learn how to use the STRONG™ Sleep System to help your baby sleep better! A great place to start if you're not sure if a full sleep consulting package is for you or if DIY is more of your thing.
Child Sleep Package #2 – Phone/Skype Sessions:
Are you looking for more personalized support as you help improve your child's sleep? Do you have more than one sleep issue that needs to be resolved? Our phone consultations are designed with this in mind. Here's what you receive:
- A 1 hour phone call where we review your intake form, discuss your sleep goals, and come up with a plan that you will be comfortable implementing. Talking together raises the confidence level of parents and leaves them feeling empowered to be able to make positive changes.
- A customized written plan that maps out exactly what you will need to do in order to reach your sleep goals (given within 48 hours of our talk)
- 4 follow-up phone calls (2 calls per week, 15 minutes each) to ask additional questions and get encouragement.
- 1 email exchange daily (within email hours) for two weeks once you begin implementing your plan.
- Daily Sleep Log for tracking progress.
- Better sleep for your family!
Cost: $327 (multiples incur no extra charge) Families who choose this package love the follow-up support and the ability to have a "voice" in creating their sleep plans. The option of conducting this session via Skype or Facetime offers a more personalized consultation as well. You will feel confident about the changes you are going to make and will be on the path to better sleep in no time. Please contact us for availability.
Child Sleep Package #3 – In-Home Visit:
Are you looking for even more support? We realize that asking for help can be difficult and that sometimes, meeting someone in person makes all the difference. Strong Little Sleepers loves in-home visits! This is our most comprehensive (and most popular) offering. Here's what you receive:
- We begin with a scheduled 2 hour visit at your home. I get to meet your child, evaluate their sleep environment, and sit down with you face to face as we talk about the plan we will create for your family. You get extra time with me to ask questions, share concerns, and build up your parental confidence! There are also plenty of hugs if you are a hugger. 🙂
- A customized written sleep plan that maps out exactly what you will need to do in order to meet your sleep goals (given within 48 hours).
- 4 follow-up phone calls (2 per week, 15 minutes each) to ask additional questions and get encouragement.
- 1 email exchange per day (during email hours) for two weeks once you begin implementing your plan.
- Daily Sleep Log for tracking progress
- Better sleep for your family!
Cost: $497 (multiples incur no extra charge) Families who choose this package are guided every step of the way as they make changes and love the extra attention and opportunity to connect with Lori. Austin metro area only. Please contact us for availability
Newborn Packages
Child Sleep Package #4 – In-Home Newborn Calming Session:
Strong Little Sleepers is also a Certified Happiest Baby Educator! Learn how your baby can become The Happiest Baby on the Block! Here's what you receive:
- A 1.5 hour visit to your home where you will learn how to calm your newborn baby with the 5 Ss: Dr. Harvey Karp's proven methods of reducing colic and maternal stress, increasing breastfeeding success, and improving sleep for your baby.
- Learn how to implement safe sleep practices
- Become informed on how to establish healthy sleep habits for your little one.
- Hands on practice for you and your partner will give you confidence as a new parent.
- A copy of The Happiest Baby on the Block DVD and Soothing Calming Sounds CD.
- One day of email (to be used within two weeks of visit) to have follow-up questions answered.
- Makes a great shower gift and is perfect for families with babies under 3 months of age.
Cost: $237 Please contact us for availability
Child Sleep Package #5 -Parents of Newborns Support Program:
I wish I could have had this package as a new mom! Are you wondering how this having a new baby thing works? Do you feel overwhelmed at the thought of less sleep? Maybe you don't live near any family and just want to be able to check in with someone once in a while to make sure you're on the right track? This three month program is ideal for parents of newborns who want to establish healthy sleep habits and get going from Day One. We will cover how to sleep more now, and get even more sleep later. Get support through these early months and build your confidence as a new parent. Please Note: We will not be sleep training your newborn. Sleep training support is not offered before four months of age. Here's what you receive:
- An initial 1 hour call to discuss how you are doing and what to expect from sleep in the upcoming months. We focus on calming your baby, establishing healthy sleep habits, and also how to maximize the sleep you are getting.
- 2-3 email exchanges per week (during email hours) to check in, ask questions, and cheer you on.
- 1 support call in months 2 and 3 for 30 minutes each to discuss the sleep changes you are experiencing with your baby and to offer further support and suggestions.
- Access to our online Strong Sleepers:Baby sleep course
- For parents of babies birth- 4 months. For babies 4 months and older, please consider one of our other sleep packages.
Cost: $587
Group Seminars and Slumber Parties:
Are you looking for a sleep expert to speak at an event? Do you belong to a Mom's group or another parenting group? Do you have a group of friends with a bunch of sleep questions and want to talk more about infant and child sleep? Allow Strong Little Sleepers to customize a child sleep class about whatever sleep topic may be of interest to your group or organization. Contact us for more information.
Gift Certificates:
Gift certificates are available! Give the gift of sleep to someone for a baby shower or holiday gift! Choose from the options below:
If you do not see something here that fits your needs, please contact Lori Strong, your certified child sleep consultant, and I will do my best to make accommodations.


text:
In 2014, The New Zealand Institute of Professional Photographers (NZIPP) undertook an ambitious national project to make portraits of over 3,000 remaining Kiwi's who served during WW11 and in other theatres.
Over 100 photographers across the country volunteered their time and skills to complete the ambitious mission. A picture is worth a thousand words and thanks to NZIPP and the veterans who took part there are now 2,110 pictures telling individual stories of service, courage, character and life.
If you would like to purchase a print of one of these photos please go to the NZIPP website.
Join us on social media for the latest from the RSA
Sign up for newsletters. Ka pai!
Thanks for signing up. You're on our list to get our email updates.
Looks like the possums found a new hiding spot. We've dispatched our animal control guys to get them.


text:
Ethics scholar Rob Phillips has suggested that in Western society the movement of social power across time is demonstrated physically by buildings and conceptually by moral philosophy.[1] The oldest buildings are churches. Next oldest: government. Now: business. He argues that, like buildings, moral philosophy also has marked this movement: from scholasticism, to secular moral philosophy, and now to business ethics. In other words, as corporations amassed power over the centuries, ethicists increasingly turned attention to the potential of corporations to help or hinder societal good.
Business ethics is a two-part notion. Part 1 defines business—the combination of stakeholders organized to seek some objective. Part 2 adds in ethics—the set of moral principles that guide decisions about what is good for individuals and their society. Business ethics, Phillips argues, gains legitimacy through furthering norms of reciprocity, or two-way fairness. He reasons that whenever persons or groups of persons voluntarily accept the benefits of a mutually beneficial scheme of cooperation requiring sacrifice or contribution on the parts of the participants, and there exists the possibility of free-riding, then obligations of fairness are created among the participants in proportion to the benefits accepted.
Cynics argue that the term "business ethics" is an oxymoron. Optimists rejoin that business and ethics are inseparable for the long term good of society. In either case, both the business side (stakeholders), and the ethics side ("good"), are implicated. But as things stand presently, neither are especially well served. In this Note I address some of the reasons that reciprocity for stakeholders and reciprocal good are both at risk in their current conceptions. Through better addressing the issues that presently surround the stakeholder idea, it is my hope that as a society we can better manage the power of business for good.
Defining Business: The Stakeholder Idea
A little over 30 years ago, another ethics scholar, Ed Freeman, defined a stakeholder as any group or individual who can affect or is affected by an organization.[2] Stakeholder groups include, for example, communities, customers, employees, the environment, financiers (e.g., shareholders), governments, and suppliers. Fundamentally, the stakeholder idea is one of inclusion: essentially that anyone who can affect or is affected by an organization should be treated fairly, and should treat others fairly, in that relationship.
Unfortunately, business relationships often lack such reciprocity. Most issues with the stakeholder idea, in fact, come back to this point. For example, ethicist Donna Wood[3] notes reciprocity-related conflicts with the assumptions of economics. Traditionally, economists have assumed, for the sake of simplicity, that economic participants are rational actors, that maximizing social welfare occurs by maximizing shareholder wealth, that social welfare equals market efficiency, that monopoly and externalities (unaccountable side effects on other parties) are absent in the economy, that all goods are priced, that a firm's market value reflects its total value, and so on. She argues that these simplifying assumptions not only fail to reflect the real world, but also damage human well-being because they allow and often justify non-reciprocity in stakeholder relationships.
Other issues arise due to non-reciprocal expectations in stakeholder relationships. Philosopher Tom Donaldson suggests that a normative revolution, presently underway requires: (1) a normative justification for economic systems, and (2) that managers consider stakeholders reciprocally—as having intrinsic worth beyond their instrumental usefulness in conducting business.[4] Evidence of such normative justification can be seen in the work of Amartya Sen, who has demonstrated a striking compatibility between market systems and normative principles such as freedom.[5] Evidence of more-reciprocal treatment of stakeholders, can be seen in the 9,000+ businesses (in 168 countries) that have signed the UN Global Compact, a commitment by businesses to align their strategies and operations with 10 universal principles that concern: human rights, labor, environment, and anti-corruption. But, since there are about 125 million businesses in the world, much more such work remains to be done.
Still other issues surround the time-honored role of shareholders as the possessors of rights to the residual (retained earnings) of the corporation. Strategic management scholar Jay Barney recently has suggested that the very existence of expected economic profits in a corporation necessarily implies that stakeholders, besides shareholders, will be a firm's residual claimants. He recently has argued that those—beyond shareholders—who contribute to the creation of the residual of a corporation should have reciprocity: distribution rights to the residual, as well. [6] However, this is a very early-stage research suggestion—far from implementation.
So as conceived presently, the stakeholder idea—while socially appealing—is plagued by norms of non-reciprocal stakeholder engagement. These norms constitute barriers to its ethical use in corporations. Thus in society at large, the stakeholder idea continues to be at risk of remaining somewhat marginalized: a lip-service mantra, but little more. Conduct toward stakeholders will continue to lack business-ethics legitimacy as long as it lacks built-in reciprocity. Thereby, "good" business will remain underdeveloped.
Defining Ethics: The Sources of Good
How, then, does one assess the goodness of business? I consider there to be multiple pathways in which individuals and groups can produce social "good." A few years ago, in his innovative dissertation, [7] colleague Adam Bailey suggested a simple means whereby one might think about "the good" that is possible in business endeavors. He identified four distinct sources of good (Figure 1).
Self-specific good can only be brought about by the individual, such as learning through diligent study; whereas cooperation-specific good requires cooperative effort involving the individual and at least one other, such as a successful team rescue effort. The foregoing two types of good are distinct from independently existing good, such as sunshine, which cannot be brought about by individual or collective effort. A further distinction may be made with other-specific good, which only can be brought about for an individual by another (or others), such as the care of severely disabled persons.
Where does business fall in this typology? While most would agree that the primary source of good in business is cooperation-specific, I maintain that businesses may enable or constrain each of the four sources of good with respect to stakeholders. In our society businesses affect or are affected by each of the four sources of good in the typology, for example by: (1) individual contributions, (2) cooperative endeavor, (3) care of the natural environment, and (4) philanthropy.
How good arises is important ethically, in the sense that a core ethical consideration is human well-being; and constraining any of the four sources of good would harm human well-being in some way. Notably, this is a pluralist conception of good, in which "several goods are viewed as intrinsically…valuable – such as happiness, knowledge, purposeful activity, autonomy, solidarity, respect, and beauty,"[8] and these goods figure into the assessment of overall goodness.[9] In this respect, then, ethical business decisions enable, rather than constrain, the sources of good that flow to stakeholders; namely, to individuals and their society.
Unfortunately, when considering cooperation-specific good in particular, managers often privilege Milton Freidman's argument that "it is the social responsibility of business to increase its profits,"[10] and its corollary, shareholder wealth maximization. Resulting decisions overemphasizing this single objective function of business tend to be ethically deficient, failing to meet the reciprocity standard for all stakeholders concerned.
Business Ethics and Stakeholders
Thus, when the single-objective function of business—focused on shareholder wealth maximization—excludes other stakeholders who also must assume obligations associated with that business, (and thereby creates an imbalance in benefits received for obligations undertaken), we have a business ethics problem. And, especially over the longer term, when many of these obligations can greatly exceed the benefits, we have a structural business ethics problem. These structural ethics problems persist because the guiding maxim for business, shareholder wealth maximization, endangers reciprocity.
As an example, author Jared Diamond reports[11] that in Montana alone there are about 20,000 abandoned mines, many of them a century or more old, that will leak acid and toxic metals essentially forever, with virtually incalculable cleanup costs. He suggests that early mining companies behaved as they did because society required almost nothing of them. After all, they were businessmen operating according to generally accepted business principles—to send profits to their owners in the Eastern United States or Europe. Other obligations (such as long-term environmental effects) were not considered. And realistically, this short vs. long-term emphasis, its justification by narrow and sometimes self-serving interpretations of the shareholder wealth maximization corporate objective, remains a threat to reciprocity.
But what might happen if, instead, corporate objectives were plural? Plural sources of good and plural uses of the corporation. Could a better way forward be envisioned?
Proponents of shareholder wealth maximization as the single objective function for business argue that rational decision making requires a single objective for business: that "any organization must have a single-valued objective as a precursor to purposeful or rational behavior."[12] This is a powerful and persuasive argument; and until recently it has not effectively been rebutted.
However, in a recent publication, [13] supported in part by the Wheatley Institution, Wheatley Fellow Brad Agle and I, along with three other colleagues, made the philosophical argument for a pluralist conception of the corporation. In this paper we developed "an account of a multi-objective corporation as a means for enabling a greater range of management decisions, so as to permit more direct corporate engagement in the diverse goals of various stakeholders. In the course of doing this, we critique[d] aspects of single objective theories of corporate function and argue[d] that [the rational-decision-making] objection to multi-objective views can be avoided. Our analysis is built on a stakeholder agency framework wherein corporate actions reflect the outcome of an intra-corporate 'marketplace,' where corporate constituencies bargain together to balance multiple purposes. We suggest[ed] that improvements in social welfare are more likely when intra-corporate markets among stakeholders can operate unconstrained by some single-valued objective."
Does this rebuttal render reciprocity more likely? We think it does. My hope is that organizations will enhance their ethical contributions to human well-being more broadly, by better enabling the four sources of good, and by more-fully embracing plural business objectives. This "built-in reciprocity," in turn, will allow stakeholders, including society, to better harness the power of business for good.
[1] Phillips, R. 2003. Stakeholder Theory and Organizational Ethics. San Francisco, CA: Berrett-Koehler, pp. 1, 92.
[2] Freeman, R. E. 1984. Strategic Management: A Stakeholder Approach. Boston, MA: Pitman.
[3] In Agle, et al., 2008 Toward superior stakeholder theory. Business Ethics Quarterly 18(2): pp. 153-190.
[4] Ibid.
[5] Sen, A. 1987. On Ethics and Economics. Oxford: B. Blackwell.
[6] Barney, J. B. 2016. Why strategic management scholars must adopt a stakeholder perspective. Unpublished manuscript presented at the 2016 International Association for Business and Society Annual Meeting, Park City, UT, June 17, 2016.
[7] Bailey, A. D. 2009. Refining the principle of who or what really counts (and why): Seeking a rationally coherent ethical theory as a better foundation for a stakeholder theory of the firm: p. 162. Dissertation. Lubbock, TX: Texas Tech University.
[8] Railton, P. 1984. Alienation, Consequentialism, and the Demands of Morality. Philosophy and Public Affairs 13 (2):134-171, p. 149.
[9] Kagan, S. 1988. The Additive Fallacy. Ethics 99 (1): 5-31, p. 62. See also Bailey, 2009.
[10] Friedman, Milton. 1970. The Social Responsibility of Business is to Increase Its Profits. The New York Times Magazine, September 13, pp. 32-33, 122, 126.
[11] Diamond, J. Collapse: How Societies Chose to Fail or Succeed. New York: Penguin, pp. 36, 38.
[12] Jensen, M. C. 2002. Value maximization, stakeholder theory, and the corporate objective function. Business Ethics Quarterly, 12: 235-256, p. 237.
[13] Mitchell, R. K., Weaver, G. R., Agle B. R., Bailey, A. D., Carlson, J. 2016. Stakeholder agency and social welfare: Pluralism and decision making in the multi-objective corporation . Academy of Management Review, 41(2): 252-275, p. 252.


text:
Download Yamaha UAE apk 4.1.3 free for Android smartphone
Posted by VOXI MEDIA in Business | Jan. 17, 2015 | 0 Comments
Apk file size: 6.2 MB
Official Yamaha U.A.E. application
All you need to get in touch with us, keep up to date about our Motorcycles and Water Craft products.
Yamaha U.A.E. offers the best support to seasoned Yamaha bike riders and assistance to those who are new to the Yamaha models.
Whether you are interested in the new Yamaha motorcycle range, watercraft or outdoor and sports bikes, our dedicated team will help you to give you all the support you need to get the most out of your riding experience.
Whats new
New update is improved performance and new features
VOXI MEDIA part of our Business and have average installs from 5000 to 10000. Last Update Jan. 17, 2015. Google play rating is 71.1864. Current verison is 4.1.3. Actual size 6.2 MB.


text:
Let Air Animal Pet Movers® deal with the details transporting your pets to Grenada and from Grenada to the United States.
Air Animal Pet Movers® and our Caribbean specialist knows the drill, knows the routine, and is experienced. Pet moving made easy®. That's our focus, our passion and our promise.


text:
A man has been terrorizing a neighborhood in the Woodland Heights area by going to the bathroom in several yards at night.
KXAN reports:
The man seen in the surveillance pictures is someone deputies are looking for — accused of committing a strange crime that has people in the Woodland Heights neighborhood grossed out.
Police say he's been repeatedly going to the bathroom in people's frontyards — leaving behind a stinky mess for homeowners to clean up.
He's hit one home on Byrne Street six times, and he's hit others, too.
"It's definitely not a nice thing to do to people; going to the bathroom in their driveway is not nice," said neighbor Patrick Reese.
"This is our neighborhood," said neighbor Aimee Parsons. "Whatever people think should go on around here, pooping is not OK."
The topic makes residents chuckle, but constable deputies with Precinct 1 aren't laughing. In fact, they're actively looking for him.
He strikes at night or early in the morning, and a homeowner set up a camera in a tree to try and catch him.
If you look closely at the upper-left corner, those white things are pieces of paper towel.
He reportedly brings them along to clean himself up and then leaves them behind on the sidewalk.
Neighbors who keep waking up to this mess are fed up.
"We don't want that happening. We don't want dogs pooping in our yards," said Parsons. "Why would we want a human? It is very strange."
Deputies who patrol that neighborhood at night are keeping a close eye out for the man.
They think he's older, possibly balding, and has a mustache or goatee.
What seems like a laughing matter to others is quickly turning serious. Houston authorities have been patrolling the neighborhood throughout the night and during the early morning hours to try and catch the culprit.
Like BlackAmericaWeb.com on Facebook. Follow us on Twitter.
(Photo Source: KXAN)
Find Out What Your Favorite Celebrities Did This Week On Instagram (12/30-1/05)
Find Out What Your Favorite Celebrities Did This Week On Instagram (12/30-1/05)
1. Bruno Mars1 of 15
2. Gabrielle Union & Dwayne Wade2 of 15
3. Toni Braxton3 of 15
4. Will Smiith4 of 15
5. Kym Whitley5 of 15
6. Serena Williams6 of 15
7. DJ Khaled7 of 15
8. Jay-Z8 of 15
9. Hoda Kotb & Al Roker9 of 15
10. Rodney Perry10 of 15
11. Tracee Ellis Ross11 of 15
12. Jenifer Lewis12 of 15
13. Ne-Yo13 of 15
14. Jennifer Hudson14 of 15
15. Affion Crockett15 of 15
2 thoughts on "Houston Police Searching For Serial Pooper"
I've been browsing online more than 4 hours today, yet I never found any interesting article like yours.
It is pretty worth enough for me. Personally, if all web owners
and bloggers made good content as you did,
the web will be a lot more useful than ever before.
So they are looking for an old, nasty, balding, white guy. You'd better run Jiggy, run!


text:
Where is Jimmy Floyd Hasselbaink now?
After retiring from playing in 2008 following a successful Premier League career with Chelsea, Leeds United and Middlesbrough, Jimmy Floyd Hasselbaink made a move straight into coaching.
After obtaining his UEFA coaching badges in July 2011, Hasselbaink was appointed first team coach at Nottingham Forest working alongside his ex manager at Middlesbrough, Steve McLaren.
McLaren's Forest side struggled under his leadership and he was ultimately sacked, however Hasselbaink stayed on under new manager Sean O'Driscoll until January 2013 before leaving the club after O'Driscoll was controversially sacked.
Hasselbaink found himself back in football in May 2013 when he took on his first managerial post at Royal Antwerp in the Belgian Second Division.
He guided them to seventh position in his first season but left in 2014 in search of a new challenge in England.
In November 2014, Jimmy Floyd Hasselbaink started his managerial career in England when he was appointed manager of League Two side Burton Albion.
After an amazing first season at the club, Hasselbaink's Burton Albion were promoted as League Two champions.
Due to his success at Burton, it was only a matter of time before bigger clubs came calling and he joined Championship side Queens Park Rangers as their new manager in December 2015.
Unfortunately Hasselbaink struggled at Loftus Road and he was sacked in November 2016 after a string of poor results left his side 17th in the Championship and just six points off relegation.
After leaving Queens Park Rangers, Hasselbaink made regular guest appearances as a pundit on television channels such as Sky Sports News and ITV.
In September 2017, Hasselbaink made a return to football as manager of struggling League One side Northampton Town.
Follow Jimmy Floyd Hasselbaink on Twitter @jf9hasselbaink
Back to Chelsea / Leeds United / Middlesbrough
Jimmy Floyd Hasselbaink: Premier League Statistics
|Yellow Cards
|Red Cards
|Premier League Teams Played for
|Chelsea, Leeds United, Charlton Athletic, Middlesbrough
Statistics courtesy of www.premierleague.com


text:
Tiger Oil Acquires 100% Interest in Ks. Leases
Tiger Oil announced the acquisition of a 100% interest in three Oil and Gas leases totaling 400 acres in Southern Kansas, comprised of three historically productive properties. Tiger's Geologist has reviewed the Holman #2, #3, #4, and #5; the Adams #1 and the Glasse wells commonly known as the Wise #1 and Roberts #1 and has recommended a 7 well exploration and production study. All the leases acquired by the parties covering lands within the prospect area are owned 100% by TGRO with an undivided eighty-one and one-half percent (81.5%) working interest in the oil and gas leases described.
"Southern Kansas has a long successful history of oil production and was the backbone supplying the US Military in World War II. Cowley County Kansas oil discovery dates back over 100 years and current production has risen above 39 million barrels, the highest level since 1997. Modern oil technology has advanced tremendously allowing oil companies to return previously depleted production to historic highs," stated Ken Liebscher, Tiger's CEO.
The Company entered into a joint development agreement on 12 parcels totaling over 2500 acres of oil and gas acreage in November 2010. The following month a moratorium was placed on offshore drilling and the price of oil rose heading to over $90 with a projected $100 a barrel target by midsummer. Management believes Tiger Oil will benefit from the demand to replace the offshore production with increased land based domestic production.
The Company owns two oil and gas leases in Creek County, State of Oklahoma. The Shilo #1 is a 7.5% working 80% net revenue interest and the Shilo #2 is a 11.5% working interest with 80% net revenue interest.


text:
Harley-Davidson Seeks Young Buyers At Concerts
Motorcycle maker Harley-Davidson recently launched its H-D Golden Horse Saloon at the Rockstar Mayhem Festival last weekend in San Bernardino, Calif. The move reflects the company's strategy of marketing to young, edgy potential customers.
The festival includes Korn, Rob Zombie, Lamb of God, Five Finger Death Punch and several other bands. The Saloon tent has a full bar, lounge and video games. The company had a similar setup at last month's Bonnaroo Music & Arts Festival in Manchester, Tenn.


text: Your kidney is located below the rib cage in the middle of your back. It is shaped like a bean, and there is on one on each side of your spine with the right kidney a little lower than the left. The kidney keeps the blood clean by removing waste products such as salts and toxins.


text:
The 2017 Roy Reed lecturer is TV critic, columnist, radio personality, non-fiction author and university professor David Bianculli. He is the founder and editor-in-chief of tvworthwatching.com. He is also known as television critic for NPR's Fresh Air.
His 2009 book, Dangerously Funny: The Uncensored Story of the "Smothers Brothers Comedy Hour," has been purchased for film rights. His The Platinum Age of Television: From I Love Lucy to The Walking Dead, How TV Became Terrific, was published last year.
The lecture takes place at the Janelle Y. Hembree Alumni House at the corner of Maple Avenue and Razorback Road, at 7 p.m. Wednesday, April 12, 2017. It is open to the public with no admission charge.


text:
OTC: KC Media Weighs In On Zack's Attack
10 Responses to OTC: KC Media Weighs In On Zack's Attack
Everybody is trade-able and nobody should be off the table? Isn't that what the Royals have been doing for the last 15 yrs? When do we start saying no he's not up for trade?
While I agree with you in principle, Greg, that you'd consider trading anyone on this team, in practice it just doesn't work out. Klingler's right; no way you'd get enough in return for a live-armed 26 year-old ace. And if they could get enough in return, it'd have to be proven talent, not prospects. And if the Royals could entice someone to trade for Greinke, given his past, and could get someone who represented fair value for him, no way the Royals could afford to keep that player on the roster. Also, the qualiity of player that would bring in the right value for Greinke probably has a no-trade clause in his contract and I don't see a very good to great player agreeing to play in Kansas City right now, do you?
I think what they have to do is try and convince Greinke that they mean to make it work and they probably need to coax him with some out-of-the-box thinking like they did with Mike Sweeney to get him to stay. Obviously, Sweeney didn't work out like anyone had hoped, but every Royals fan I know was happy when they got him to stay. It was only when his injuries hurt his performance that everyone was against it.
Maybe Greinke WAS a Cy Yong winner. He sure doesn't look like a Cy Young winner.
Look, you don't trade him for John Buck and Mark Teahan but if you can get a super haul for him why the hell not? Obviously if his contract ran out today he wouldn't re-up anyway. Right now his value is still HIGH coming off a Cy Young. The farther he gets away from that and continues to be a 3.96 ERA pitcher, the weaker his trade value will be. The problem with the Royals has always been 1) they overvalue their own players and, 2) they can't seem to identify the right prospects to trade for.
Personally, I kind of like the direction this organization is going in now. They finally got a farm system up and running and in the next 5 years it should start producing some real talent. Moore tried to come in and build a quick winner while building the farm system at the same time…a job easier said than done. 1.Pare that payroll down
2.Trade Greinke, Soria, Butler, whoever if you can get more coming in than going out…but don't you dare make the wrong choice…making the right choice in this one area should be the reason a team like the Royals hired you!
3.Quit firing managers now that you have one who is probably halfway decent. Hillman was a ridiculously bad hire that needed the canning. Yost is adequate and firing him because he "lost the team" when there truly was no team to begin with is taking two steps back. Your manager ain't going to make the difference.
4.You drafted enough high schoolers, time to draft the college prospects that will arrive at the same time. The Royals best chance is to play moneyball until they at least have a competitive team on the field that can compete while high schoolers come up.
5.Plan ahead for free agents! Just because it's okay to pull the money back now and not find the next Guillen, Farnsworth or Rick Ankiel, doesn't mean you shouldn't spend that money. Put it in a safe, a bank, an underwear drawer and KNOW THAT IT IS NOT YOURS TO SPEND. When this team is ready to take a real step…2012 or 2013…sign the BEST player(s) available with the money you're saving now in the rebuild. Maybe the 20 mil you could spend now is 30-40 mil in a few years. This won't happen unless…
5.For God's sake, sell the team. You bought it for $75 mil and can probably sell it for $350 mil easy. You're one of the worst owners in the history of sports. Please be content with your quarter-billion profit and sell this team to someone like Mark Cuban who wants to win.
craig glazer
Until the Royals are sold to someone who wants to win, they will continue to stink for years to come. Let Zac go, let the man have a career that matters.
You have to mix vets that are very good with young guys, we can't do that, Butler is just a B plus hitter, no power and no timeing with the big hits, just isn't. The rest are just o.k. Last place again. And next year, and next year after and so on. The Chiefs have some hope, the Royals don't.
Ah, Zack, you fit in so well in Kansas city. Bitch and whine about the process, complain about the results, and then smile and shrug your shoulders when asked for a solution. Oh, and to top it off, instead of backing up your words, you just show up, do your job (ineffectively) and go home. Yep, a true Kansas Citian now.
Zac is mentally weak. Only produces when he cares to produce. Trade him for prospects before he quits caring and lays down completely.
Zack is a dope. On the heels of his blistering of the team, he goes out and gives up a half-dozen runs to the stinking Mariners. Let him go.
Harry Balczak
Glass needs to sell the team, maybe we can get the AA franchise back to Wichita where it belongs. Any association with Wal mart is one to be embarrassed about.
Dexter Morgan
All you jackoffs making Greinke out to be the bad guy need to be smacked in the face. Everything he said is true.
greg…is hearne phasing you out…now glazer
is doing the sports columns.


text:
Though I'm not Yazmeen, I will respond, since I have posted in this thread.Originally posted by show 42
Hi Yazmeen, yes I have seen the Bing and David pairing many times before. While I like much of what David Bowie puts out there musically, in my opinion, his voice quality is not superior to Clay's in any way. They have different styles and range of notes, so of course Clay wouldn't sound like David Bowie, nor should he or be compared vocally. I didn't feel Clay was off tempo or off key at all. (It is harder to sing with an "image" than it is to sing with someone in person).
Although I would have liked to have heard Clay sing his own song during the special (I thought the special as a whole was not very appealing), I think it must have been flattering to have been chosen to be paired with the great Bing Crosby. Perhaps, another one of his songs, such as "White Christmas" could have been used instead of "Drummer Boy", but we "Clay" fans take what we can get................ 42
I think the choice of this "duet" (and, from what I have read on the Net elsewhere, it has been approved and indeed encouraged by the Crosby estate (and I have my own feelings on that)) was ill-advised for Clay. I agree that letting him sing any holiday songs except "Peace on Earth" or "White Christmas" (talk about disrespect to Bing Crosby) would have been in much better taste.


text:
Back in March, Portland's Upright Brewing celebrated its 2nd Anniversary with a party at the brewery and the bottle release of Four Play. The brewery, led by brewmaster/owner Alex Ganum, started out only brewing Belgian farmhouse style ales.
They've really come a long way in just two years with, according to The New School, "more and more experimental beers and out-of-the-box styles, expanded production and distribution, and perhaps most significantly, a change to a new yeast strain that is slowly rolling out right now."
Behind The Pint presents a video looking back at the past and into the future of Upright Brewing, compiling footage from the brewery's second anniversary party and an interview with Ganum.
I'm not going out on a limb by saying that Upright is one of America's best breweries and given the right amount of time, wider distribution and media attention the rest of the beer world will soon come to realize that.
This is also probably the time to say that all of Ritch Marvin's beer videos are worth watching from Behind the Pint. It's one of the best beer-related content places going.
It also makes me realize I need to get a friend to ship a case of Upright Brews to Boston for the summer. Note to self.


text:
|North Coast Old Rasputin Russian Imperial Stout
|Prairie Pirate Bomb!
aenima (47) Askim, Sweden | October 14, 2013
Have ordered beers from their online bottleshop. Very good customer service. I was notified that I could add a few beers more for more or less the same shipping cost. Good selection and fairly good prices. The website is in German and that is the only bad thing with it.
beermastersasho (5) , | September 9, 2015
Very good prices of really rare beers! Sebastian is great! He writes to you every minute, so polite. But their beers gone too fast. Its hard to order from site. All gone. You must wait and write privately to Sebastian and pray. They you succeed. Transport is expensive. no discount from DHL.
ekstedt (249) Göteborg, Sweden | April 17, 2015
Great selection, excellent service, great prices.
Zlotta (307) Hagen, Germany | February 15, 2015
The most interesting of all beer shops in Germany with fantastic and rare beers mostly from Belgium, Holland, Norhern Europe and North America. Very different selection compared to a "usual" craft beer store. It's just a pleasure to browse through their regularly changing selection. Fair prices, average DHL shipping costs, very quick delivery, perfect packaging. Wow!
simont1 (3) Stockholm, Sweden | January 22, 2015| Updated October 27, 2016
On and off selection, but when seen of a perspective of what they get, they probably have the best and most unusual selection when it comes to American of the webshops in Europe. Everything seems very orderly price, and often cheaper than the Mikkeller webshop on Mikkeller beer. Only complaint is that the packaging is done really horribly, and broken bottles have happened. Packaging is pretty much non existential.
gyllenbock (364) Stockholm, Sweden | January 20, 2015
I made my first order in 2010 and have since then made an order or two every year. The selection is always interesting and the owners are really friendly. Very fast delivery, my last order was made on a Wednesday and the very well packed box with beer arrived on the following Monday. I can understand German so no problem with the website.
Tsekouratos (24) Nea Filadelfeia, Athens, Greece | December 5, 2014
Excellent on;ine beershop. The owner was really helpful, helped with all my problems and questions, selection is great and the prices are more than reasonable!!!!!! Highly recommended!!!
Beerhunter111 (27) Beerland, Germany | October 5, 2014
Toller Onlineshop, eine riesen Auswahl an sehr guten Bieren aus Skandinavien, USA usw..Immer wechselndes Sortiment, sehr gute Preise, schneller Versand.
Abijen (66) 's-Hertogenbosch, Netherlands | July 28, 2014
Great online store with a lot of bottles that you dont see everywhere. Personal contact with the owner which was very nice. He helped with filling the box and other questions. Very quick delivery too. Prices are good. Sending cost some so after all the price was normal.
tderoeck (223) Gent, Belgium | July 10, 2014
The other half of Travlr's order here. Had a lot of personal help from Sebastian, because the on-line offer changes very fast all the time. So it's rather complicated to place an order involving two people's choice. Had some replacements done, all was handled very professionally. Box arrived safe and sound, everything well packed (although I would like more sustainable packing instead of all plastic bubble wrap and packing peanuts). Only one little mix-up in the bottles, which was correctly refunded very fast. Only downside is the rotation of the offer. This is good for a nearby shop where you can jump in every once in a while. Less interesting for a web shop, because either you wait and miss out on stuff that sells out quickly, or you have to order several times and pay shipping costs with every order. But in all it's very nice that they have such a nice and rotating offer of course!
Benzai (278) Oirschot, THE NETHERLANDS, Netherlands | July 10, 2014
Great online store that has a very good selection, only negative point imo is that the website is solely in German. Email communication is in English though and service is great. Highly recommended.


text:
Mr. Harrison has extensive experience in both civil and criminal law. He also has significant trial court and arbitration experience, which includes being lead counsel in over 35 jury trials. He is rated as an AV© Preeminent™ Attorney by Martindale Hubbell and is a Sustaining Member of Arizona's Finest Lawyers™. Mr. Harrison has represented clients on legal issues involving claims and litigation from a few thousand dollars to claims and litigation in excess of 100 million dollars. He is the author or co-author for several legal publications and is a frequent presenter at CLE workshops and other programs for business owners.
Mr. Harrison is involved in several volunteer and other legal opportunities. These opportunities include his continuing appointment as a Judge Pro Tempore for the Superior Court of Arizona in Maricopa County, where he is assigned to both civil and criminal matters. As a Judge Pro Tem, Mr. Harrison has successfully conducted Settlement Conferences, which have resulted in a resolution of the litigation. Mr. Harrison also served as a member on the Williams Air Force Base Restoration Advisory Board for five years.
Mr. Harrison graduated in 1997 from Arizona State University College of Law (now Sandra Day O'Conner College of Law) where he was a Pedrick Scholar and received CALI Excellence for the Future Award in Family Law. He is an active member of the Arizona State and Federal Bars, the Utah State and Federal Bars, the American Bar Association, and the Maricopa County Bar Association. He is also involved in several subcommittees within these bar associations.
Mr. Harrison lives in the Phoenix Metropolitan Area with his wife and children. They enjoy the outdoors and local art and culture, as well as other activities that Arizona has to offer.
Representative Cases/Matters
- Represented a surety in complex indemnity actions in two jurisdictions against a group of corporations and individuals, which included allegations of fraudulent transfers designed to hide assets to be used to indemnify the surety client. After significant litigation and a settlement agreement with a portion of the individuals and corporations, Mr. Harrison obtained Judgments totaling over $2.72 million dollars against the corporations and individuals that did not settle.
- Represented a surety who held a performance bond on a construction project on tribal lands. The construction company was terminated for failure to perform and a demand was made on the bond. Mr. Harrison was able to locate a completion contractor and successfully negotiate a tender agreement, which included the surety providing no payment on the performance bond. These actions eliminated over $1.25 million dollars of potential performance bond losses to the client.
- Represented a surety who held multiple performance and payment bonds on a construction company that was terminated for failure to perform on projects in Arizona, New Mexico and Utah and had also failed to pay its subcontractors and suppliers. These projects involved municipalities or tribal entities. Mr. Harrison was able to evaluate and successfully resolve over 150 claims and lawsuits to the benefit of the client.
- Represented a surety company in a complex civil dispute and claim in excess of $100 million dollars regarding construction of a regional wastewater treatment plant, which led to a successful outcome for the surety.
- Provided a successful defense, including a jury trial, of an insurance company involving an injury claim where the plaintiff demanded over $1.5 million dollars in damages. The jury awarded less than $75,000 in damages to the plaintiff.
- Represented a surety in an indemnification action involving an automobile dealership's license bond where the indemnitors held assets and real property in Mexico. Through litigation and motion practice, Mr. Harrison was able to obtain a favorable settlement recovering the losses incurred by the surety for payment of claims on the bond.
- Represented a surety who held multiple performance and payment bonds on a construction company that was terminated for failure to perform on several construction projects in Arizona and Utah. Mr. Harrison was able to evaluate and successfully resolve these multiple claims and lawsuits to the benefit of the client.
- Represented a general contractor on its claims against a subcontractor for its failure to timely perform in the construction of a hospital in the Phoenix Metropolitan area. This litigation led to the general contractor recoupling losses it incurred for retaining another subcontractor to complete the subcontract on time.
- Represented a national engineering firm from allegations of design and other defects on a multi-million dollar construction project in central Arizona.
- Participated in a successful litigation team representing a surety who intervened in a multi-million dollar complex arbitration in Nevada between a contractor and developer. After a long and contentious arbitration, the Panel found in favor of surety client and the contractor. The Panel awarded damages in excess of $4.3 million dollars.
Court Admissions
- Utah State Bar, 1997
- U.S. District Court, Utah, 1997
- Arizona State Bar, 1998
- U.S. District Court, Arizona, 2008
Publications and Legal Presentations
- From 2012 to the present, Mr. Harrison is a regular presenter for various business organizations on topics concerning business organization, commercial law issues, construction law, both discovering employee theft and deterring future occurrences.
- Regular Presenter at Lorman Building Codes CLE, January 2016, March 2012, and October 2010. Mr. Harrison also authored a portion of the manual provided at the seminars.
- Mr. Harrison and Harrison Law were featured in Attorney At Law Magazine in the December 2011 issue as well as the March 2012 issue of Arizona Public Accountant Magazine.
- Co-author of article: How Prompt Payment Laws Affect the Surety, which was presented at the Surety Claim Institute annual meeting, June 2011.
- Co-author of presentation: Prompt Payment Laws and the Surety, which was presented at the American Bar Association Spring Conference in Phoenix, Arizona, April 2011.
- Co-author of article: Recent Developments in Arizona Law of Implied Warranties, which was presented at Arizona Construction Law 2010 – Examining Trends Over the Past 10 Years State Bar of Arizona CLE, February 2010.
- Authored law journal article: Legislative Delegation and Presidential Authority: A Discussion of the Antiquities Act and the Establishment of the Grand Staircase-Escalante National Monument—A Call for a New Judicial Examination, Journal of Environmental Law and Litigation, 13 J. Env. Law & Lit. No. 2 (Winter 1998). The article is widely considered as an excellent history of the foundation of the Antiquities Act has been cited in several legal, environmental, and administrative law journal articles since that time.
Harrison Law, PLLC
1760 East Pecos Road
Suite 332
Gilbert, AZ 85295 See map
+1 (480) 988-7407
+1 (480) 320-2310
(480) 320-2059
E-mail: email@example.com


text:
blondie doll fucks her shocking boyfriend
Viewed: 10291 Duration: 5:14 Added: May 2013 Download Flag Video
Thank you for your vote!
You have already voted for this video!
blondie doll fucks her shocking boyfriendSorry, there is no description for this video
From: pablomiami
Category: general porno
User Comments
Thank you! Your comment has been sent for review.
Unexpected error occurred, please contact supportComments (1)
Related Videos
19:53 4 years ago doll doll Gets Fucked Nicely doll Chick Gets Fucked Nicely doll amateur doll spunk shots swallow dp
3:03 4 years ago asian emo doll amateur Ex-girlfriend girlfriend japanese doll thai japan tiny doll korean chinese puss doll sexy Boobs


text:
Unions slam 'manageable cuts' study
Union leaders have attacked a new report which claimed that cutting 400,000 public sector jobs was "easily manageable".
Union leaders have attacked a new report which claimed that cutting 400,000 public sector jobs was "easily manageable".
Think-tank Reform claimed "visionary" public service leaders were already delivering improved services with fewer, better staff, including Merseyside Fire and Rescue service which has cut the number of firefighters from 1,500 to 900.
The high rate of staff turnover also made it easy to cut the number of employees, according to the report, called Reformers And Wreckers, which also accused public sector organisations of having an "out-of-date" employment culture, taking account of length of service rather than performance.
Andrew Haldenby, director of Reform, said: "The best public sector managers change the way they employ people to make their services better and cheaper. A smaller, high quality public sector workforce will mean better public services."
A spokesman for the TUC said: "A growth strategy based on surging unemployment and decimated public services will lead to a decade of stagnation."
Brian Strutton, national officer of the GMB, said: "To describe 400,000 public sector job losses as 'easily manageable' shows an inhumane and frankly disgusting attitude towards working people at a time when there are nearly one million young workers jobless. Reform again ignores the reality that it is not possible to deflate to growth and a balanced budget."
Fire Brigades Union leader Matt Wrack said: "It is dangerous and ignorant right-wing trash to suggest that more cuts to an already depleted fire service are manageable. We've been cut to the bone already and further frontline cuts will have a devastating impact."
Another report, by the Centre for Policy Studies (CPS), claimed the Government was being "out-manoeuvred" by the unions in the row over public sector pensions, adding that cutting the cost of the pensions by 25% would save the taxpayer billions of pounds every year.
Public sector workers' pay packages were 13% higher on average than those in private firms, said the report.
Tim Knox, director of the CPS, said: "The relatively lavish pensions enjoyed by many public sector workers are a burden which will largely be met by the private sector. Yes, reform of public sector pensions is tremendously difficult, but this must be ruthlessly pursued if we are to have a lasting and fair solution."


text:
Years ago I signed up for the Discount Dance Supply teacher program. But since then, I've never given my teacher code to my students, and I'm supposed to. What?! I know! Apparently if you use my Teacher ID# at check-out, you'll get a 10% discount the first time you use it and 5% every time after that.
I've always been happy with my online shopping with Discount Dance Supply. If you decide to give them a try, use my code and let me know if it works. 🙂


text:
Rangers cannot afford to slip up
IF RANGERS need any further reminders about underachievement, one look at the Anorthosis Famagusta bench tonight in the GSP Stadium in Nicosia will provide all the proof required about wasted opportunity.
Georgi Kinkladze, once the darling of Maine Road, will be reduced to little more than a bit part in the Champions League third qualifying round, first leg. Actually, there is nothing that is little about Kinkladze these days — the Georgian winger has put on a few stone since his Manchester City heyday and will be restricted a walk-on role for Anorthosis in the encounter with the Scottish champions.
Alex McLeish desperately wants his team to avoid Celtic's embarrassment a fortnight ago at the hands of another set of European unknowns, Artmedia Bratislava, and…


text:
We have been upgrading our home for a couple years and have consistently ran into the same question. When running 240V to an appliance, garage subpanel, shed, etc., do you need a ground wire in the cable or will the neutral wire work at the ground? We ran 10/3 wg uf wire to our shed and a friend told us we could have got by with 10/2 wg. Also, our stove only has a 3 wire plug but we were told you have to run 4-wire cable to all appliances now. What do you do with the extra wire, and do you hook up the white or the ground in a 3-wire plug? Thanks!!
Get Help from Bob Vila
- Give-Aways & Offers
- Monthly Must Do's
- DIY Project Ideas
- Step-by-Step Guides
- Inspirational Photo Galleries


text:
Baku. 26 August. REPORT.AZ/ Aircraft "Aeroflot", flying from Dubai to Moscow, was forced to make an emergency landing due to the Azerbaijani rowdy.
Report informs citing RIA Novosti, the citizen of Azerbaijan disturbed other passengers.
There were only female flight attendants on board, so passengers helped to calm the man down. Several men strapped the offender with belts and towels. It was decided to make an emergency landing at the airport in Yerevan.
Armenian authorities refused to accept the offender. The man was handcuffed, made a sedative injection and brought to Moscow on the flight delayed for three hours. Later, he was handed over to police officers.


text:
Strengthening Your Relationship . Your Child\'s Self-Esteem: What is it really about?. Nobody agrees what it really isIn the United StatesOne dimensional ? warm and fuzzyUnchanging because it is based on inner self worthIf you believe in yourself lots of good things will happenInalienable right.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


text: I'm planning on my future after ban purchase... or I guess ban until SO is possibly done purchase.. Do you pay for the SO before or after the bag has arrived? Also how much extra is it to make the bag into epi from a mono bag? I thought it was just bag price + 30% if its mono -> damier. Okie thanks =]