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Optimization of vascularisation in axially vascularised matrices in tissue engineering
Optimierung der Vaskularisation von axial durchbluteten Matrizes im Tissue Engineering
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|March 6, 2014
Nowadays, autologous tissue transplantation represents the gold standard for the reconstruction of large tissue defects. To minimize the resulting donor side morbidity and to overcome the limitations regarding shape and volume of bone grafts research has focused on tissue engineering of axially vascularised tissue constructs. We have evaluated different strategies to improve the vascularisation of bioartificial transplantable tissue volumes. First we used angiogenic growth factors such as VEGF and bFGF in the subcutaneous and arteriovenous loop model in the rat to increase vessel ingrowth. Afterwards we combined the intrinsic vascular pathway of the arteriovenous loop model with an additional extrinsic vessel ingrowth by using a porous titanium chamber. Transplanted cells also showed an increased survival in the AV loop model compared to subcutaneously implanted matrices. In this manuscript we show the evolution of different newly developed methods to improve vascularisation of axially vascularised matrices in tissue engineering.
Für die Therapie angeborener und erworbener Gewebedefekte, z.B. im Bereich des Knochens, stellt heutzutage nach wie vor der autologe Gewebetransfer den Goldstandard dar. Um den hierbei resultierenden Hebedefekt und die Einschränkung hinsichtlich Formbarkeit und Länge/Volumen des verfügbaren Gewebes zu minimieren, steht das Tissue Engineering von axial vaskularisierten Gewebekonstrukten im Fokus des wissenschaftlichen Interesses. Wir untersuchten verschiedene Forschungsansätze, um die Vaskularisation von bioartifiziellen, transplantierbaren Gewebekonstrukten zu verbessern. Es wurden eine Steigerung der Vaskularisation mit Hilfe verschiedener angiogenetischer Wachstumsfaktoren im Subkutanmodell und in einem arteriovenösen Gefäßschleifenmodell in der Ratte gezeigt sowie eine Kombination der arteriovenösen Gefäßschleife mit peripher einsprießenden Gefäßen mit Hilfe einer neuartigen porösen Titankammer nachgewiesen. Mit Hilfe der Gefäßschleife konnte zudem ein erhöhtes Überleben von transplantierten Zellen im Vergleich zu nicht vaskularisierten Matrizes gezeigt werden. Die hier vorgestellte Arbeit zeigt die Entwicklung neuartiger Ansätze zur Optimierung der Vaskularisation von axial durchbluteten Matrizes im Tissue Engineering.
Procedure and findings
The reconstruction of large bone defects represents an important research field because nowadays therapy is limited. In the clinical routine autologous tissue transplantation still represents the gold standard for the reconstruction of bony defects [1], [2]. Advantages of the autologous bone transplantation are their given osteoconductive, osteoinductive and osteogenic activity [3], [4]. Depending on the indication the bone graft can be used in different shapes such as chips and blocks [5], [6]. Known disadvantages of the autologous bone transplantation are beside the limitations in form and volume the donor side morbidity including the possibility of infections, hematomas, seromas, chronic pain or paraesthesia at the donor side [7]. Areas of limited vascularisation e.g. caused by irradiation or trauma or large bone defects require microsurgical transfer of vascularised bone grafts such as fibula, iliac crest of scapula bone [8], [9], [10].
Tissue engineering is defined as an interdisciplinary field with the aim to create bioartificial tissue to maintain, improve or substitute organ functions [11]. The engineering of bioartificial bone tissue represents one major research field in the area of tissue engineering. Most tissue engineering concepts lack the initial vascularisation of the constructs, therefore transplantation of cell containing matrices are often limited because of a high initial cell loss. Diffusion can only maintain viability of cells in a range of 200 µm in the surrounding of vessels [12], [13]. Vascularisation is crucial for any successful in vivo tissue engineering model. Vascularisation can be achieved by an extrinsic or intrinsic pathway using a defined vascular axis. The advantage of an intrinsic vascularisation is the possible microsurgical transfer using the vascular pedicle.
We have evaluated different strategies to improve vascularisation of bioartificial transplantable bone constructs. We used the arteriovenous loop model in the rat, first described by Erol and Spira in 1979 [14]. This model relies on an arteriovenous vessel loop, created in the medial thigh of the rat using an interpositional vein graft of the contralateral thigh. Afterwards the AV loop is placed in an isolation chamber containing the tissue matrix. After a defined vascularisation period the constructs containing AV loop and matrix are explanted and vessel ingrowth as well as bone generation are evaluated using histology and/or micro-CT.
Based on the results of other research groups of our laboratory we implanted a processed bovine cancellous bone matrix in the arteriovenous loop model of the rat [15]. In the first operation the AV loop and the matrix were implanted and placed in the chamber and after a vascularisation period fibrin gel immobilized CFDA (carboxyfluorescein diacetate succinimidyl ester) labeled osteoblasts were injected in the matrices. Subcutaneously implanted matrices containing the same matrix and osteoblasts served as a control group in this study. At the explantation time point matrices were perfused using India ink to detect functional vessels in the histological processing. We were able to show an increased survival rate of osteoblasts in the AV loop group compared to the control group. Furthermore bone generation and expression of osteoblast-specific gens were increased in the AV loop group compared to the subcutanous group.
To minimize the time interval between AV loop implantation and cell injection we studied different strategies to increase vascularisation speed of the axially vascularised constructs. Therefore we tested different angiogenic growth factors in a newly developed upside-down subcutaneous implantation technique with the opening of the chamber facing the muscular layer of the back of the rat and not the dorsal skin [16]. Using this technique we were able to maximize the contact area between matrix and host organism and to minimize shear forces leading to a more homogeneous construct area. We evaluated the angiogenic potential of the angiogenic growth factors VEGF165 (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor) in five different concentrations and combinations at the contact area between construct and musculature. We were able to show a significant increase of vessel number and generation of vascularised connective tissue with an optimum between 25 ng/ml and 100 ng/ml VEGF and bFGF.
Based on these results we evaluated the angiogenic effect of fibrin gel immobilized VEGF and bFGF in four different concentrations in the arteriovenous loop model of the rat [17]. The evaluation was based on conventional histology and micro-CT. We detected a significant increase of angiogenesis in the AV loop model at a growth factor concentration of 100 ng/ml each.
Afterwards we applied 100 ng/ml VEGF and bFGF in a hydroxyapatite/tricalciumphosphate bone matrix and implanted the constructs in the AV loop model of the rat [18]. The evaluation was performed using conventional histological techniques and a newly developed automatic three dimensional micro-CT evaluation (in cooperation with A. Hess, Institute of Pharmacology and Toxicology, University of Erlangen-Nuremberg, Erlangen, Germany) (Figure 1 [Fig. 1]). We were able to show an increase of vascularisation speed of the HA/TCP matrix in the AV loop model using the angiogenic growth factor combination.
Afterwards we invented a porous titanium chamber in cooperation with C. Koerner (Institute of Science and Technology of Metals, University of Erlangen-Nuremberg, Germany) in order to combine the intrinsic vascular pathway with an additional extrinsic vascularisation to increase vascularisation of matrices. First we were able to show, that a connection between the intrinsic and extrinsic vascular pathways takes place over time, because otherwise no benefit in vascularisation would be detectable after transplantation using the vascular pedicle of the intrinsic vascular pathway [19]. Two weeks after implantation 83% of all vessels showed a connection with the AV loop whereas after 8 weeks nearly all vessels (97%) were connected with the AV loop. Therefore a transplantation of the entire construct using the vascular pedicle is possible, which is mandatory for later clinical applications.
We also evaluated different fibrin sealants with varying fibrinogen, thrombin, aprotinin and factor XIII concentrations in terms of matrix degradation and vascularisation in the AV loop model of the rat [20]. We found out, that mainly the fibrinogen concentration influences the matrix properties and that there was an inverse relationship between the matrix degradation and vascularisation.
Tissue engineering has arised over the last decades and has the potential to change clinical practice in reconstructive surgery in the future. Besides bone tissue many studies focus on tissue engineering of muscle, fat or skin using a plethora of highly innovative biomaterials combined with stem cells and growth factors. The initial euphoria caused by successful in vitro studies was followed by sober recognition that the transfer of these results into an in vivo environment has proved to be difficult. Vascularisation has emerged to be one of the crucial steps towards clinical application of engineered bioartificial tissues. When in vitro constructs are transferred into an in vivo environment scaffolds have to rely on diffusion and on a newly generated extrinsic vascular network. To overcome the limited initial vascularisation reconstructive surgeons prefer an intrinsic type of vascularisation that could be transferred to the defect site using microsurgical anatomosis leading to an immediate perfusion of the entire scaffolds. Optimized vascularisation techniques may allow the transfer of engineered tissue into the demanding in vivo environment and may help to bridge the gap between bench and bedside.
Competing interests
The authors declare that they have no competing interests.
This study was supported by research grants from Baxter Healthcare Corporation, Xue-Hong and Hans Georg Geis, the University of Erlangen (ELAN Program), the AO Research Fund Grant S-10-36A and the ''Emerging Fields Initiative'' of the University of Erlangen-Nuremberg.
The authors thank Prof. Peter Greil and Mr. Peter Reinhard for production of the Teflon chambers. This work contains parts of Andreas Arkudas' habilitation thesis.
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Merry Christmas wishes to all my readers!
When is Christmas celebrated?
What do we know about Christmas?
Most of us know that Christmas is on December 25th and that's all there is to Christmas.
Do you know that for many people around the world, in different countries and in different Christian traditions, Christmas lasts for a longer time – and is infact celebrated at different times?
Although December 25th is the date when Christmas is celebrated, there are some other dates as well! Have a look….
Some churches (essentially Orthodox churches) use a different calendar for their religious celebrations. Orthodox Churches in Russia, Serbia, Jerusalem, Ukraine, Ethiopia and other countries use the old 'Julian' calendar and so Christmas is celebrated on January 7th in these countries.
Most people in the Greek Orthodox Church celebrate Christmas on December 25th. But some still use the Julian calendar and so celebrate Christmas on 7th January!
In Armenia, the Apostolic Church celebrates Christmas on January 6th. It also celebrates 'Epiphany' on this day.
Why is Christmas on 25th December?
Christmas is celebrated to remember the birth of Jesus Christ, who is believed to be the Son of God.
The name 'Christmas' comes from the Mass of Christ (or Jesus). A Mass service (also called Communion or Eucharist) is where Jesus died for the sake of humanity and then came back to life. The 'Christ-Mass' service was the only one that was allowed to take place after sunset (and before sunrise the next day), so people had it at Midnight! So we get the name Christ-Mass, shortened to Christmas.
Christmas is now celebrated by people around the world, whether they are Christians or not. It's a time when family and friends come together and remember the good things they have. People, and especially children, also like Christmas as it's a time when you give and receive presents!
Merry Christmas Celebrations
Christmas is celebrated not just on one day, 25th December. But the celebrations start before that and continue 40 days after Christmas.
The Tradition of Advent
Advent is the period of four Sundays and weeks before Christmas. Advent in Latin means 'Coming'. This is the coming of Jesus into the world. The time of Advent is used to prepare and celebrate the joy of Christmas.
There are three meanings of 'coming' that Christians describe in Advent. The first happened about 2000 years ago when Jesus came into the world as a baby to live as a man and die for us. The second can happen now as Jesus wants to come into our lives now. And the third will happen in the future when Jesus comes back to the world as King and Judge, not a baby.
Some people fast during Advent to help them concentrate on preparing to celebrate Jesus' coming. In many Orthodox and Eastern Catholics Churches, Advent lasts for 40 days and starts on November 15th and is also called the Nativity Fast. In Orthodox Churches which celebrate Christmas on 7th January, Advent starts on 28th November!
The 12 Days of Christmas
The 12 Days of Christmas starts on Christmas Day and last till the evening of the 5th January – also known as Twelfth Night. Throughout history, the 12 Days of Christmas were a time of feasting and fun.
The 12 Days each traditionally celebrate a feast day for a saint or have different celebrations:
- Day 1 (25th December): Christmas Day – celebrating the Birth of Jesus
- Day 2 (26th December also known as Boxing Day): St Stephen's Day. He was the first Christian martyr (someone who dies for their faith). It's also the day when the Christmas Carol 'Good King Wenceslas' takes place.
- Day 3 (27th December): St John the Apostle (One of Jesus's Disciples and friends)
- Day 4 (28th December): The Feast of the Holy Innocents – when people remember the baby boys which King Herod killed when he was trying to find and kill the Baby Jesus.
- Day 5 (29th December): St Thomas Becket. He was Archbishop of Canterbury in the 12th century and was murdered on 29th December 1170 for challenging the King's authority over Church.
- Day 6 (30th December): St Egwin of Worcester.
- Day 7 (31st December): New Years Eve (known as Hogmanay in Scotland). Pope Sylvester I is traditionally celebrated on this day. He was one of the earliest popes (in the 4th Century). In many central and eastern European countries (including Austria, Bosnia and Herzegovina, Croatia, the Czech Republic, Germany, Hungary, Israel, Italy, Luxembourg, Poland, Slovakia, Switzerland and Slovenia) New Years Eve is still sometimes called 'Silvester'. In the UK, New Year's Eve was a traditional day for 'games' and sporting competitions. Archery was a very popular sport and during the middle ages it was the law that it had to be practiced by all men between ages 17-60 on Sunday after Church!
- Day 8 (1st January): 1st January – Mary, the Mother of Jesus
- Day 9 (2nd January): St. Basil the Great and St. Gregory Nazianzen, two important 4th century Christians.
- Day 10 (3rd January): Feast of the Holy Name of Jesus. This remembers when Jesus was officially 'named' in the Jewish Temple. It's celebrated by different churches on a wide number of different dates!
- Day 11 (4th January): St. Elizabeth Ann Seton, the first American saint, who lived in the 18th and 19th centuries. In the past it also celebrated the feast of Saint Simon Stylites (who lives on a small platform on the top of a pillar for 37 years!).
- Day 12 (5th January also known as Epiphany Eve): St. John Neumann who was the first Bishop in American. He lived in the 19th century.
Twelfth Night
Twelfth Night was a big time of celebration with people holding large parties. During these parties, often the roles in society were reversed with the servants being served by the rich people. This dated back to medieval and Tudor times when Twelfth Night marked the end of 'winter' which had started on 31st October with All Hallows Eve (Halloween).
Twelfth Night is also known as Epiphany Eve. In many countries its traditional to put the figures of the Wise Men/Three Kings into the Nativity Scene on Epiphany Eve ready to celebrate Epiphany on the 6th January.
It's also traditional to take your Christmas decorations down following Twelfth Night.
Candlemas – The End of Christmas
After both Christmas and the season of Epiphany, the end of the Christmas celebrations comes on February 2nd, 40 days after Christmas, with Candlemas.
Candlemas, also known as the 'Presentation of Jesus at the Temple' or the 'Feast of the Purification of the Virgin (or Mary)' is the when some Christians remember the time when Mary and Joseph took the baby Jesus to the Jewish Temple in Jerusalem to give thanks to God for giving them a son.
The name Candlemas comes from 'Candle Mass' because in many Candlemas services, the candles are blessed to be used in churches during the coming year or are given out to people for them to use in their homes and private prayers.
In many Catholic churches, it's a time when people remember and renew promises they've made to the church and celebrate some of the prophesies which were given about Jesus.
In many Eastern/Orthodox churches, an all night vigil is held on the night before the candle blessing ceremony. In the morning, the candles are blessed and are given out to people.
Also Read: Happy New Year 2017: Traditions, Wishes, Quotes, Greetings
Merry Christmas Greetings and Merry Christmas Cards
Christmas is a magical time of the year. Spread happiness with these beautiful Merry Christmas Greetings and Merry Christmas Cards.
Merry Christmas Wishes 2017
Merry Christmas is the most said word at the time of Christmas. People meet at the party, hug each other and convey Merry Christmas Wishes. If you are looking for Merry Christmas Wishes 2017, Merry Christmas Quotes then you are at the right place. Here are the best Merry Christmas Wishes for you.
Wish you Merry Christmas and a Happy New Year!

subset: commoncrawl


text:
Jeff Cornell
22 Years Ago: Alice in Chains Release Their Self-Titled Album
Alice in Chains released their third full-length album on Nov. 7, 1995. The self-titled effort marks the band's final album with vocalist Layne Staley, who passed away in 2002.
25 Years Ago: Alice In Chains Unleash 'Dirt'
'Dirt' cemented Alice In Chains' place in rock 'n' roll history and stand out as one of the musical highlights of the 1990s grunge era.
26 Years Ago: Queensryche Unleash 'Empire'
When Queensryche released their fourth album Empire, back in 1990, the stars aligned for the progressive metal outfit.
21 Years Ago: Queensryche Release 'Promised Land'
Queensryche released their fifth album, Promised Land, on Oct. 17, 1994. The effort arrived in a much different musical landscape than its predecessor, the group's 1990 landmark album Empire.
Queensryche 'Condition Human' – Album Review
With 'Condition Human,' the thinking man's metal band is back with a fury reminding fans of their early and most popular albums.
Geoff Tate Talks Operation: Mindcrime Trilogy, 'The Key' Album + Working With Dave Ellefso…
Geoff Tate dishes on Operation: Mindcrime's plans for a trilogy and offers insight into 'The Key,' the first album in the trilogy.
Operation: Mindcrime, 'The Key' – Album Review
Operation: Mindcrime's 'The Key' will speak to the hardcore Queensryche and Geoff Tate fans, who enjoy the challenge of listening to an album over and over to unlock the mystery and discover the stories within the story.
Geoff Tate Talks 'Rough' Split With Queensryche + 'Musical Project' Operation: Mindcrime
Geoff Tate shares his relief over having Queensyrche's legal matters in his past and discusses his new 'musical project' Operation: Mindcrime.
Queensryche Unleash New Track 'Hellfire'
Get a listen to the new Queensryche song 'Hellfire' ahead of their 'Condition Human' album release.
King Diamond to Film Feature Length DVD on 'Abigail in Concert' Tour
Yes, King Diamond will have the cameras rolling during the 'Abigail in Concert' tour.


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WEXCO Logo & Stationery Design
Design an environmental logo with stationery.
The company's name has a very unique and memorable ring, WEXCO, a name that is derived from the words Water Experts Company. The client strongly wanted to use the blue and green colors, which is commonly used for environmental companies and businesses. From the stationery to the website, we added an arching curved graphic to the branding, symbolizing energy and life.
Project was completed while employed by a St. Cloud, Minnesota advertising agency.


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The District completed a demonstration project using chunks of chipped wood (Chunkwood) for road surfacing material this summer. One parking area and two roads in the Oregon Mountain area were selected for this innovative project that used wood chips and chunks from the District's fuels reduction project in the same area.
The concept of chunkwood for road surfacing was introduced in the mid-1970's. It provides a clean and stable material for stabilization and erosion control on light duty, low-use roads, parking and access areas. It is an alternative to more costly materials such as rock or shale, and in this demonstration the chips are produced nearby on the fuels reduction project.
Initially, the project sites were prepared by correcting minor drainage concerns. Next, the areas were graded and shaped. Geo-textile fabric was installed over the prepared road surface. Finally a 4 to 8 inch layer of wood chunks/chips was applied. Project Manager John Condon described the benefits of this project. It tied it into an existing fuels reduction project; allowed the District to expand the fuels treatment area, because of cost-savings on both projects; used the biomass generated from the fuels project (the wood chips) on-site; and reduced our reliance on the more costly disposal method of burning.
This project was completed with funding from U.S. Forest Service under the Economic Action Program of the National Fire Plan through a grant to the Trinity Resource Conservation & Development Council (RC&D), which sounds a lot like the Trinity County Resource Conservation District (RCD).
For additional information contact:
Scott Eberly, Coordinator
Trinity RC&D
(530) 623-2009 ext. 3
Return to the Trinity County RCD Home Page


text: a GF BINed an item she really really wanted without checking the shipping first (and it required instant payment). now that reality has set in she realizes that she paid almost double the actual cost in shipping and the seller is ignoring her. i told her she's SOL and should have done something before she BINed but she wants to report it to eBay for excessive shipping. can she do this? will eBay do anything? she wants the item but she wants to punish the seller for being greedy. i despise sellers who charge excessive shipping but i think that once you pay, you're stuck (especially if you want to go thru with the auction). what do you think?


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McAfee: 'App Collusion' Latest Mobile Security Risk
McAfee identifies common apps that could be commandeered by attackers to steal information or carry out financial transactions
Out-of-date versions of common mobile applications could be commandeered by cyber-criminals to steal information, carry out illicit financial transactions and misuse services, according to a new study from Intel's McAfee Labs, which also found a continued increase in ransomware attacks and macro malware aimed at enterprises.
The study is the latest to highlight the new and often as-yet undetectable security risks posed by mobile devices, particularly those that haven't been updated regularly or that have been rooted or jailbroken.
New threat
The lab's threat report for June 2016 found that more than 5,000 versions of 21 consumer mobile applications could be used in a type of cybercrime it calls mobile app collusion, where software with different capabilities are made to work together to bypass security controls.
"The failure of users to regularly implement essential software updates to these 21 mobile apps raises the possibility that older versions could be commandeered for malicious activity," McAfee said in a statement.
The apps carry out common functions such as mobile video streaming, health monitoring and travel planning, McAfee said.
App collusion involves the use of one app that has access to restricted information or a restricted service and another that has access outside the device. Ordinarily different applications are isolated using sandboxes that prevent them from communicating with one another, but mobile platforms also include "fully documented ways for apps to communicate with each other across sandbox boundaries," McAfee stated.
Data theft
The technique can result in the theft of confidential information, the execution of illicit financial transactions or the misuse of services, the firm said.
While app collusion has been considered a theoretical threat for years, McAfee said this was the first time the capability has been identified in particular software, which could be exploited via accidental data leakage or a malicious library or software development kit.
"It should not come as a surprise that adversaries have responded to mobile security efforts with new threats that attempt to hide in plain sight," stated Vincent Weafer, vice president of the McAfee Labs group.
The lab said it is working on tools to identify and stop such attacks and advised users to download applications only from trusted sources, avoid software with embedded advertising, avoid "jailbroken" or "rooted" mobile devices and keep apps and operating systems up to date.
Ransomware continues to rise
The report also documents the return of a Trojan horse called Pinkslipbot, capable of stealing banking credentials, email passwords and digital certificates, which first emerged in 2007 but has reappeared since late last year including new features designed to make it harder to detect and reverse-engineer.
McAfee found that new ransomware samples rose sharply by 24 percent in the first quarter of this year, as relatively low-skilled criminals began using this type of malware, generally via exploit kits which automate the exploitation of software vulnerabilities.
New mobile malware samples rose by 17 percent quarter-over-quarter in the first quarter, and has grown 113 percent over the past four quarters, McAfee found.
Macro malware increased by 42 percent quarter-over-quarter, continuing the trajectory that began last year for this new threat, which is often used to attack enterprises via sophisticated spam messages that use information gathered through social engineering, McAfee said.
Mac OS malware also rose sharply by 68 percent in the first quarter, mainly due to an increase in a type of adware called VSearch, but McAfee noted that the total number of Mac OS samples is still low.
A botnet called Gamut became the biggest spam producer in the quarter, growing in volume by nearly 50 percent and generally sending out get-rich-quick or pharmaceuticals emails, the study found.
Are you a security pro? Try our quiz!
RESEARCH: Who will benefit most from the Internet of Things (IoT)?


text:
Multicolored Placement Print Anarkali Kurti
Brand: Zovi
Price: Rs. 899
Rich colors and appealing prints have been infused into this printed kurti to give you an ethnic look that is full of life. Multicolored kurti. Prints all over. Different print on the border and sleeves. Stand collar. Three-fourth sleeves. Pair it with leggings, slip into peep toes and wear a few bangles for an impressive look. Fabric: 100% CottonModel Statistics: Height - 177 cm / 5 ft. 8 inchesBust - 84 cm / 33 inchesWaist - 71 cm / 28 inchesModel is wearing size S.
|Dress Style


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CodePlexProject Hosting for Open Source Software
- added ContainsPoint
- added Vertices accessor to directly access the Vertex array
- added BoundingBox that is only calculated when needed
- added ComputeZ that takes a point within the triangle and calculates interpolated z value
- added ContainsPoint required by ITriangle (throws exception)
- added Bounds accessor required by ITriangle (throws exception)
- new constructor taking a list of triangles
- removed IsPointInTriangle and used Triangle.ContainsPoint instead
- changed to use original Triangle objects rather than list indexes
- change Query to return first valid triangle encountered and return null if none are found rather than creating a new list and returning FirstOrDefault()
- replaced the code that determined what region a triangle belonged to (wasn't always working)
- added z (not used for triangulation, only interpolation on the result triangles)
- added ContainsPoint
- added Bounds BoundingBox accessor
- added new constructor that takes a collection of triangles and determines min/max from their vertices
- added Intersects method that checks if the bounding box intersects another bounding box
- added EdgesIntersectTriangle that determines if any edge on the bounding box intersects any edge of the triangle
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More than 20 volunteers spent three hours cleaning up the abandoned house on Apple Street in Pittsburgh's Homewood neighborhood, better known as the first home of the National Negro Opera Company, on Saturday, November 29, 2008.
YPA teamed up with RenewPittsburgh to board up and clean up the 7,000 square-foot Victorian. The board-up/clean-up effort was an important step toward the restoration of the historic house.
In addition to RenewPittsburgh, YPA is grateful to PA State Senator Jim Ferlo and Operation Better Block.
Built in 1894, the house on Apple Street was first purchased by Pittsburgh numbers king Woogie Harris, in 1930. Woogie Harris was the brother of famed photographer Teenie Harris. The house served as the home of the first black opera company in the United States. The NNOC was started by Homestead native Mary Cardwell Dawson in 1941. The NNOC grew to include a number of chapters around the country. First Lady Elanor Roosevelt and Marian Anderson were honorary board chairs. Among the people who came through the house include Ahmad Jamal and Lena Horne. The house also hosted a number of Steelers, including Roy Jefferson, John Nesby, and Marvin Woodson, as well as Roberto Clemente.
YPA coordinated the replacement of a state historical marker in 2007 (the original one had been ripped down). That same day, both the Mayor of Pittsburgh and City Council issued proclamations honoring the National Negro Opera Company. The house became a City Historic Landmark in spring 2008 and is eligible for listing on the National Register of Historic Places.
A condemnation notice was issued on November 7, 2008, which inspired YPA to take action to ameliorate the condition. YPA has also established a separate fund for the house's restoration. Donations can be directed to the YPA NNOC Fund and sent to our Homestead headquarters:
Young Preservationists Association of Pittsburgh
110 East Eighth Avenue
Homestead, PA 15120
Inquiries can be directed to firstname.lastname@example.com


text: Video News: United States Today in History August 18 Highlights of this day in history: Mongol ruler Genghis Khan dies; Women in U.S. clinch right to vote; James Meredith graduates from Univ. of Miss.; Vladimir Nabokov's 'Lolita' published in U.S.; Actor-director Robert Redford born. (Aug. 18)Copyright 2013 The Associated Press © DailyMotion - Sunday, August 18, 2013


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The Brazil Diaries is an intimate look at the Perre twins aka How&Nosm, European graffiti artists and professional muralists residing in New York. There has been much interest in their new work. In times when a multitude of colors, techniques and effects tend to overcompensate for style, How&Nosm take the opposite approach.
125 pages, soft cover.
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07.Nov.2013 Feedback for Bob Decarolis
From chilln72, in the comment section of the last thread:
Dear Beaver Nation,
I have done some legwork and there now is a direct line to the AD and Athletic Dept to voice your concerns and the direction you would like to head. This will be coming in the following weeks on pure orange and message boards. Displeased OSU went from 5 uniform combinations to only 3? Now there is a way for us fans to let them know. Basically this is a collaboration spurred by a line between my ex boss at Nike and those inside the department he has regular contact with. Through my efforts and the discussions that follow your voice can now be considered as part of general feedback. Many have been displeased by trends continuing at OSU when supporters seem to want certain changes but it has been difficult for the AD and dept to always know what fans really want.
So now please start by replying to this notification with the ideas that OSU fans would like to see to better support their university's teams. So whether you want the possibility of black pants with orange unis, white lids with black jerseys or tartan endzones state it here. If you have ideas for gameday experience or increasing basketball attendance also add those here.
Together, consider this a first step to allowing the little guy a voice. Yes the AD and dept will make the ultimate decisions but know there is a channel for ideas to be added and hopefully a better mix of ideas and implementations to result.


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About This Game
- Summary
- Specifications
- Game Editions
Lost Saga is an action-packed online fighting game that brings heroes from fantasy, science-fiction and history to life in an all-out-brawl for the ages.
Up to 16 players battle it out online over temples, cities and nature. With 28 heroes to choose from and over 100 heroes slated to become available throughout the game's lifespan, Lost Saga promises to bring an ever changing battle. Lost Saga also comes with multiple game modes and customizable heroes. Best of all this entire game can be enjoyed without spending a dime!
- Minimum Requirements
- OS: Windows 98/2000/XP/Vista/7
- CPU: Intel Pentium III 800 MHz
- VGA: 3D support Graphic Card
- HDD: More than 1GB
- Direct X: DirectX 8.1b
- Supported Functions
- Online
Lost SagaPublisher: OGPlanet (GameFactory)Release Date: 2011
Help us solve the toughest (or most puzzling) game puzzles and challenges.
Our attempt to answer issues which most commonly occur on IGN's wikis.


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Spider 'which gives victims painful erections' in Lidl bananas horrifies mum
A TERRIFIED mum discovered a "venomous" spider and its babies in a bunch of bananas she got from budget supermarket giant Lidl.
The horrified Lidl shopper was surprised to find the creepy crawly nest brimming with potentially dangerous Brazilian wandering spiders.
Luckily, the arachnid – believed to be a Brazilian wandering spider – was dead when found.
But the scary-looking beasts have a very venomous bite which gives blokes painful four-hour erections.
Daily Star Online warned sport fans heading to the Olympics in Rio.
"I don't like spiders but I went along because something needs to be done"Geoff Grewcock
But now they are making their way here to Britain in bananas.
And the beasts have enough poison to kill a human.
Geoff Grewcock, Nuneaton and Warwickshire Wildlife Sanctuary manager, was alerted to the scene by the shocked woman.
"I don't like spiders but I went along because something needs to be done," he said.
"I was shocked when she pulled this one out."
Mr Grewcock sent the creepy crawly and the egg sack off for the species to be verified.
But he suspects it is a Brazilian wandering spider, which are notorious for their aggressive behaviour and toxic bites, travelled in from Colombia.
And the so-called armed spiders have been named as the most venomous spider in the world.
Now the unnamed shocked woman's house is being fumigated.
He added: "There were some young things in there too.
"If you have a dangerous spider in your house you want it out of there straight away.
"You cannot have these things running around in your house, you cannot mess about, you've got to put that danger out of your house."
The expert advised to put any suspected dangerous spiders in the freezer to stun them.
A Lidl spokeswoman said: "We have thorough procedures in place to ensure that the freshfruit and vegetables available in our stores are of the highest possible quality for our customers.
"We are therefore very sorry to hear that these standards were not met on this occasion.
"The matter will be fully investigated by our quality assurance team."
The shopper bought the bananas from the Queens Road.


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Product or Service
Chiavari Chair,Chivari Chair,Tiffany Chair
Profile:Manufacturer - Producer|Ref:PSL16128YH | Country: China | Export: No
Our most popular ballroom and rental chair.
Stackable design maximizes storage/transport efficiency (7 chairs high).
Mechanical joints keep your chairs ready to rent and out of the wood shop.
Solid wood seat that will not warp, crack or delaminate.
The chairs are compatible with other brands of chairs that stack.
Available in Gold, Silver, White, Black, , Mahogany, Nautral& custom colors
500+ lbs. Tested.
Ships assembled and stacked 9pcs/carton.
High density cushions bring you comfortable feeling,
Cuhions with velcro ties in Ivory, White, Black and Burgundy
Specification: Seat Height: 18" Overall Height: 36" Width: 16" Seat Depth: 16" Weight: 12lbs
Other Description:
432PCS/ 20'feet Container 900pcs/40'feet container 1017pcs/40'feet High container
Package: 8 to 9 pcs per carton (assembled)
Min. Order: 432pcs
Qty Available: 5, 000pcs
Delivery time: 15days
Price Terms: FOB, CIF
Usual Payment Terms(Negotiable):
30%T/T in advance, Rest before shippment
Shippment method: By Sea
FOB Price: (pls tell us quantity for exact quotation)
Contact the company


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Walcott was born and raised in Castries, Saint Lucia, in the West Indies with a twin brother, the future playwright Roderick Walcott, and a sister, Pamela Walcott. His family is of African and European descent, reflecting the complex colonial history of the island which he explores in his poetry. His mother, a teacher, loved the arts and often recited poetry around the house.[6] His father, who painted and wrote poetry, died at age 31 from mastoiditis while his wife was pregnant with the twins Derek and Roderick, who were born after his death.[6] Walcott's family was part of a minority Methodist community, who felt overshadowed by the dominant Catholic culture of the island established during French colonial rule.
As a young man Walcott trained as a painter, mentored by Harold Simmons, whose life as a professional artist provided an inspiring example for him. Walcott greatly admired Cézanne and Giorgione and sought to learn from them.[6] Walcott's painting was later exhibited at the Anita Shapolsky Gallery in New York City, along with the art of other writers, in a 2007 exhibition named "The Writer's Brush: Paintings and Drawing by Writers".[7][8]
He studied as a writer, becoming "an elated, exuberant poet madly in love with English" and strongly influenced by modernist poets such as T. S. Eliot and Ezra Pound.[3] Walcott had an early sense of a vocation as a writer. In the poem "Midsummer" (1984), he wrote:
Forty years gone, in my island childhood, I felt that the gift of poetry had made me one of the chosen, that all experience was kindling to the fire of the Muse.[6]
At 14, Walcott published his first poem, a Miltonic, religious poem in the newspaper, The Voice of St Lucia. An English Catholic priest condemned the Methodist-inspired poem as blasphemous in a response printed in the newspaper.[6] By 19, Walcott had self-published his two first collections with the aid of his mother, who paid for the printing: 25 Poems (1948) and Epitaph for the Young: XII Cantos (1949). He sold copies to his friends and covered the costs.[9] He later commented,
I went to my mother and said, 'I'd like to publish a book of poems, and I think it's going to cost me two hundred dollars.' She was just a seamstress and a schoolteacher, and I remember her being very upset because she wanted to do it. Somehow she got it—a lot of money for a woman to have found on her salary. She gave it to me, and I sent off to Trinidad and had the book printed. When the books came back I would sell them to friends. I made the money back.[6]
The influential Bajan poet Frank Collymore critically supported Walcott's early work.[6]
With a scholarship, he studied at the University College of the West Indies in Kingston, Jamaica.[10]


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Deals in unani medicated herbal tonics
The Tayyebi Dawakhana Unani Private Limited
No.73,nakkeerar Street,thenpalani Nagar, Tamil Nadu - 600099, India


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Free Internet Browsing From Vodafone Ghana on WTISD
Saturday May 17 was World Telecommunication and Information Society Day (WTISD).
Vodafone Ghana chose to celebrate with its customers in a grand way. It offered fee internet browsing to its customers at selected retail shops to celebrate this year's World Telecommunication and Information Society Day (WTISD).
The WTISD, which is celebrated on 17 May, was formed to observe the formation of the International Telecommunication Union.
The noble idea of Vodafone was to raise awareness about the endless possibilities of using the internet and its benefits to communities.
This year marks the 150th anniversary of the International Telecommunication Union. WTISD is said to be a day set aside to help raise awareness of the possibilities that the use of the Internet and other information and communication technologies (ICTs) can bring to societies and economies, as well as of ways to bridge the digital divide.
It is an annual event observed on 17th May by the International Telecommunications Union (ITU) to mark the founding of the ITU and the signing of the first International Telegraph Convention in 1865.


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This was created by a wonderful guy we met while visiting Viña del Mar, Chile. He's originally from Valdivia, and when we told him we were going there in a few weeks, he emailed us this amazing list of travel tips. ¡Gracias, Otto!


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**I'll be adding these to the link up so you can read all about them**
Fall Linky Party
**I'll be adding these to the link up so you can read all about them**
13 comments
Hello! I just wanted to let you know I added this linky at http://www.squidoo.com/teachinglinkies.ReplyDelete
pick me! pick me! :))) I wrote a perfect little entry today to link up!ReplyDelete
Rowdy in Room 300
This is such a great idea!! I shared a link about my Counting Candy Corn packet!!ReplyDelete
1...2...3...Teach With Me
Dots of Fun!
Just added my link. All of these products look great!ReplyDelete
Hi, I am brand new to blogging and not so new to TPT, I have a fall literacy packet I would love to promote on your site if not too late, I wanted to ask you. It is on Pinterest and TPT if you want to look at it first. I really like your blog as well.ReplyDelete
thank you
Tama Trotti
What a great idea! Thank you for sharing! I am a new follower and can't wait to read more.ReplyDelete
TIPS: Teach, Inspire, and Prepare Students
Thanks for doing this....I am also having a linky party for differentiation on my blog if you'd like to join at http://teachingside.blogspot.com/2012/09/differentiation-and-linky-party-to-go.htmlReplyDelete
I was able to contribute a couple of free fall items and pinned your post. Thanks for the link-up!ReplyDelete
FANTASTIC IDEA!! I'm so happy I found your Blog! Stop by and check out mine :-) SMILESReplyDelete
- Stephanie @ Middle School Matters BlogOctober 02, 2012 2:31 pm
So happy I found your blog! A great place to share ideas - and you now have a new follower, too! :) Thank you for the chance to link-up.ReplyDelete
Great job! Come join my first linky party: http://who-is-on-first.blogspot.com/2012/10/my-first-linky-party.htmlReplyDelete
LOVE this freebie! Thank you! :)ReplyDelete
Mrs. Lirette's Learning Detectives


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DESSAU, Germany & ROCKVILLE, Md.--(BUSINESS WIRE)--IDT Biologika, a globally integrated contract manufacturer of vaccines and biopharmaceuticals, accepted a CMO Leadership Award for overall quality, reliability, capabilities, expertise, compatibility and development during a ceremony held yesterday in New York City. Sponsored by Life Science Leader magazine, the annual awards recognize the top contract manufacturing organizations (CMOs) serving the pharmaceutical and biopharmaceutical industries.
IDT Biologika Chief Executive Officer Dr. Ralf Pfirmann accepted the 2017 CMO Leadership Award on behalf of the company. "With our competence and wide range of capabilities in industrial development and manufacture, IDT is the most helpful partner for all organizations working on new solutions with the mission of bringing new vaccines or biological drugs to patients," said Dr. Pfirmann. "Our increasing worldwide recognition is based on our dedication to serving these needs. The success of our customers is highlighted by the multiple categories of the CMO award in which we are decorated this year."
Winners were evaluated based on real-world experiential data and feedback from decision makers who work with contract manufacturing suppliers. IDT was judged by its customers as a top performer among more than 80 CMOs. The company achieved this high honor in all six categories across 30 performance metrics considered important to the selection of a CMO and based on customers' direct experience working with IDT on an outsourced project within the last 18 months. Life Science Leader teamed up with Industry Standard Research (ISR) to conduct the Contract Manufacturing Quality Benchmarking survey that captured input from decision makers.
The award adds to IDT's distinguished reputation in the contract services business and celebrates the company's ongoing commitment to manufacturing excellence. Today, IDT offers a wide range of services during all phases of vaccine and biopharmaceutical development - from early research and process development through clinical and mass commercial manufacturing.
IDT continues to increase its global footprint and has expanded its infrastructure in Dessau, Germany and Rockville, Maryland. The company is particularly focused on developing new medical solutions for the U.S. market and recently become a prime contractor for the Biomedical Advanced Research and Development Authority (BARDA), an office of the U.S. Department of Health and Human Services. For more information, visit IDT Biologika on the web at www.idt-biologika.com.
About IDT Biologika
IDT Biologika is an innovative, privately-held company with nearly 100 years of experience in researching, developing, manufacturing and marketing products for the global protection of human and animal health. The company produces vaccines and pharmaceuticals according to the highest quality standards, for its own animal health products and under contract.
Company sites in Germany include the BioPharmaPark in Dessau-Rosslau and the Riems district of Greifswald. IDT's Animal Health business is marketed internationally from its offices in Denmark, the Netherlands, France, Spain, Poland and Canada. In the United States, IDT Corporation operates a production site for clinical test samples in Rockville, Maryland. In Canada, IDT Biologika subsidiary Gallant Custom Laboratories manufactures autogenous vaccines. The same vaccines are produced by the recently acquired IDT subsidiary in the United Kingdom, Ridgeway Biologicals.
In 2015, IDT Biologika registered sales of $195 million in animal health and contract manufacturing of vaccines and parenteral products. IDT Biologika currently employs around 1,700 workers worldwide.
IDT Biologika is a member of the Klocke Group, which is specialized in contract production and packaging of medications, vaccines and cosmetic products. As a traditional family-owned company, the Klocke Group employs a workforce of more than 2,200 people at eight production sites and sales offices around the world. For more information, visit www.idt-biologika.com.


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I'm so tired of installing applications and plug-ins on computer systems that all ask me -- and default to assuming yes -- would I like to install extra toolbars and (for me) useless utilities on the computers I am working on.
NO, I DO NOT WANT {insert add-on application/toolbar name here} ON THESE SYSTEMS. If I did want that toolbar/application I know exactly how to go get it, where to place it for easy and convenient access to get it loaded on to systems that I'm working on, and need not have it SHOVED in my face by these 'partners' that are supposedly trying to be overly helpful.
In reality the reason these toolbars/applications are getting shoved in my face is so that the people that provided the other applications I wanted will reap some financial rewards for helping to get me to take these other applications from their partners.
I've had enough of this whole tired system though. I don't want to have to answer no, or click off the check box. Yes, I'm glad I at least have the choice, and yes, I know that the people that provided the other plugins and tools that I'm installing are providing them for free thanks to (perhaps) some of the money they are getting paid by Google and Yahoo! (and eBay, etc.) for shoving these toolbars/applications at me, but I really wish that the apps/plugins/toolbars that I want came -- for lack of a better term -- naked and without all of the extra crap.
I know I can be lazy and just remove the unwanted toolbars/apps later if they are 'accidentally installed' and I do wind up having to do just that many times where someone installed these toolbars and didn't know that they didn't have to do it (and don't want/use the new toolbars anyway). I hate doing that though because I never know if someone really wanted these toolbars or not, and like many applications that get installed in Windows, you never know what extra crap comes along with the toolbars/apps that you'll never be able to truly get rid of.
Perhaps it wouldn't be such a pain if these applications/toolbars truly, completely, seamlessly removed themselves when you uninstall them but so many of them don't even come close to doing that and I don't want to have to be a freakin' computer genius to know what files I can remove later without ill-effect on the systems I'm working with.
Yes Google and Yahoo! I'm pointing at you people. At the same time I'm pointing at Sun (installed Java lately? Did you wind up getting Google toolbar with it??), and pointing at Adobe (installed Acrobat Reader lately? same problem), and Real (who already offers up enough of their own crap-ware/bloat-ware add-ons with their products) and others.
I'm also pointing at OEMs and system builders like Gateway/Acer/E-machines, and Dell (who has finally awoken to the idea that they should sell systems that don't force all of the add-on applications onto the buyers of their systems, but of course they charge a little extra for it, which is the obvious trade-off that is made in the equation here), and Lenovo, and HP/Compaq, and Toshiba, etc.
All are GUILTY! Guilty I say! of stealing computer CPU cycles and horsepower out from underneath us as they install all of these add-ons on our systems through their partnership deals and through defaults that make us opt-out, rather than opt-in to having these things pushed onto our PCs.
I hate those as well, and always uninstall them when I go to work on a computer.


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Financing your education abroad may mean multiple sources of funds including scholarships and fundraising. The Office for Education Abroad has its own scholarships, but be sure to look at other opportunities, especially in your MSU college(s) and also sources outside MSU.
Jump to:
Office for Education Abroad Scholarships | Scholarships for MSU Colleges & Units External Scholarships | Fundraising
MSU undergraduate students applying to any credit-bearing study abroad program are eligible for Office for Education Abroad Scholarships. MSU graduate students applying to join a credit-bearing group program abroad are also eligible; however, graduate students pursuing individual or independent research abroad are not. A special award is reserved for MSU medical students participating in a College of Human Medicine or College of Osteopathic Medicine study abroad experience. About 30 percent of students who apply for OEA scholarships will receive an award.
You need only submit one application in order to be considered for all the Office for Education Abroad scholarships for which you are eligible.
The Education Abroad Undergraduate Research Scholarship, sponsored by the Associate Provost for Undergraduate Education and the Office for Education Abroad, provides financial support for undergraduate MSU students to participate in approved accredited education abroad programs that have an undergraduate research component.
To apply, complete the EA Undergraduate Research Program Scholarship Form.
Other scholarships for research abroad may be available from external sources as well.
Learn more about research abroad.
The Dr. Charles A. and Marjorie A. Gliozzo Endowed Scholarship for Domestic and International Internships provides financial support for undergraduate MSU students to participate in approved accredited internship programs. Financial need is not a factor in awarding this scholarship. Scholarships for variable amounts ranging from $500 to $1500 will be awarded to recipients.
The Drs. Yash P. and Saroj Kapur Endowed Scholarship for Independent Study in India provides financial support for MSU students to participate in independent study in India for which they are receiving academic credit at MSU. Applicants must be MSU students with an overall GPA of 2.0 or higher at the time of application, plan to participate in an independent internship in India, arrange for credit with their MSU college, and cannot have traveled to India before the independent study or have family living in India. There may be additional eligibility criteria that students need to meet in order to receive credit.
To apply, complete the Kapur Endowed Scholarship Form.
College of Agriculture and Natural Resources
College of Arts & Letters
Eli Broad College of Business
College of Communication Arts and Sciences
College of Education
College of Engineering
The Honors College
Jewish Studies Program
James Madison College
Lyman Briggs College
College of Natural Science
College of Nursing
Residential College in the Arts and Humanities
Resource Center for Persons with Disabilities
College of Social Science
College of Veterinary Medicine
Center for Latin American and Caribbean Studies
MSU Scholarship Search
MSU National/International Fellowships & Scholarships
The Bridging Project offers scholarships to American undergraduate students participating in study-abroad programs in Japan.
Aimed at increasing education opportunities for non-traditional student populations. The Diversity Abroad Network also has an opportunity for a summer scholarship.
FEA scholarships are intended to meet the financial needs of students who might not be eligible for government grants or existing funds limited to specific programs or groups of students.
Provides an extensive list of scholarships available for specific requirements or university programs.
Lists scholarships available for certain program types or locations.
Awards grants designed to help support undergraduates as they seek knowledge and experience in their academic fields by studying abroad.
BUTEX awards sixteen scholarships to students studying abroad for either a semester or for a whole academic year. Eight scholarships are available to North American students studying in the UK.
IIE administers several scholarship programs, including the Freeman-Asia program, Benjamin A. Gilman International Scholarship, Fullbright, and David L. Boren Scholarships and Fellowships.
IIE Generation Study Abroad Travel Grants are available for U.S. students from a broad range of backgrounds to make it possible for them to participate in academic, internship or service-learning experiences abroad.
Global grants support large international activities with sustainable, measurable outcomes in Rotary's areas of focus.
Scholarships are awarded twice a year to passionate students who want to explore the world.
$500 scholarship for full-time CVM students who are of Hispanic, African-American, Native American, Pacific Islander or other minority designation.
Fundraising will help to make your program more affordable, and it also educates the public about education abroad. Local, regional and national groups, as well as individuals, are all possible contributors.


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TONASKET – A public meeting was held requesting vacation of a portion of the First Street right-of-way between the alley and Tonasket Ave. South, blocks 13 and 14 at the July 26 Tonasket City Council meeting. The council approved the ordinance following a review by Permit Administrator Christian Johnson, with the city retaining a general municipal easement for the existing utilities. The request was presented by attorney Dale Crandall for owners Bob and Margaret Hirst, which will make the property more handicap accessible.
Tonasket approves street vacation
Tonasket City council hears presentation on Enloe Dam
TONASKET – Dan Isaac of Tonasket and Oroville's Joseph Enzensperger presented a report on the economic risks of Enloe Dam to the Tonasket City Council Tuesday, July 26. Mayor Patrick Plumb gave them the floor for a long and fact-filled presentation before telling them he was offended by their request for support, due to possible contamination of Tonasket's water should the dam be removed.
Colville Tribes continue legal fight for Columbia River cleanup
NESPELEM – The Confederated Tribes of the Colville Reservation this week renewed its call for Teck Metals (the operator of a large smelter in Trail, British Columbia) to stop polluting and start cleaning up decades of its waste. A recent federal court ruling in the ongoing legal battle against Teck has reinforced the Colville's resolve to hold the polluter accountable.
Slideshow | Oroville Spring & Summer 2016
Events and Festivals in and around Oroville, Washington for 2016 Spring and Summer, so far…
Naillon takes oath of office for Oroville Council
OROVILLE – After taking the oath of office, Ed Naillon returned to the Oroville Council at their Tuesday, July 19 meeting. Naillon volunteered to fill the position left by Jon Neal when he was selected as mayor after Chuck Spieth passed away.
Zwicker suddenly terminated from hospital, almost
TONASKET North Valley Hospital CEO Mike Zwicker was terminated Thursday, July 28 at the Board of Commissioners regular board meeting – however, a mistake in the process means he is instead on administrative leave until a new resolution can be passed.
Asmussen and Kester lead in race for PUD Commissioner #3
OKANOGAN – Jerry D. Asmussen and Aaron Kester were the two top vote getters for the office of Okanogan County PUD Commissioner, District 3, in last Tuesday's primary.
Sawyer takes over as Director of Nursing Services at NVH
District planning to open sleep lab, Aug. 8 "From all the different options of reimbursement, the strongest option that was supported by all was the subsidizing of the emergency room from the communities." Mike Zwicker, CEO North Valley Hospital District TONASKET – North Valley Hospital has chosen Lori Sawyer as an interim Director of Nursing [...]
PUD commissioner candidates answer to the crowd
A large turnout of voters with lots of pertinent questions attended an Okanogan County PUD commissioner candidate forum held July 20 at the Community Cultural Center in Tonasket, leaving candidates with the impression the public is ready for commissioners to hear their views.
Former councilman Ed Naillon returns to Oroville Council
OROVILLE – At their Tuesday, July 5 Oroville City Council has agreed Ed Naillon's request to fill an empty council seat until the next election.


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Doing Maximum Likelihood Estimation by Hand in R
By John Myles White on 4.21.2010
Lately I've been writing maximum likelihood estimation code by hand for some economic models that I'm working with. It's actually a fairly simple task, so I thought that I would write up the basic approach in case there are readers who haven't built a generic estimation system before. First, let's start with a toy example […]
Posted in Programming, Statistics | 24 Responses
Theme Change
By John Myles White on 4.20.2010
I've changed the theme on this blog to the Hybrid theme. I was tired of how busy the old theme was, and I wanted more space for graphics and code snippets. If you have any suggestions for cleaning things up even more, please let me know.
Posted in Site News


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Guys, Is it a turn on or turn off if a girl loves her cats and always talks about them?
What Guys Said 18
As long as you dont answer your own questions to the cats. Cause other wise thats just a little strange. Cause then your talking to yourself.10|10|0
its always a good sign if a woman talks to her animals , especially cats ; I am a cat person10|10|0
it is neither a turn on nor a turn off. It is entirely non-sexual.00|00|0
It depends. If you are, like, obsessive then its a turn off. But, if you just happen to like them, like someone may like a certain type of candy bar, then it doesn't really matter.
Moderation is the key to most things.10|10|0
It's OK. I like cats too.10|10|0
Cats are fun, but you should have something better to talk about00|00|0
Absolutely not!
For me, it is a deal breaker if she does not like cats.
I have five rescue cats.00|00|0
It's ok to love cats.
It's ok to always talk about them.
It's NOT ok when it's the only things they talk about.
It's NOT ok when they're the only thing they love.00|00|0
Uhh.. no thanks.00|00|0
People say when you don't love animals you aren't able to love people... so it is no bad thing at all00|00|0
Well. . if it is pussy it will definitely be a turn on ;)00|00|0
Turn off, It's not heathy or normal.00|00|0
Lol. Not to me... One of closest friends is the neighbour's cat.00|00|0
Yes. maybe if he likes ur cat as much as u do ud be fine otherwise nah.00|00|0
Yea it's pretty stupid00|00|0
it's neither a turn on or turn off lol. it'd be weird if a guy got turned on by a girl talking about her cats.10|10|0
Turn on. I love cats00|00|0
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eFront, the popular Learning Management System by the leading eLearning solutions provider Epignosis, has been named a Category Leader in GetApp's Top 25 Learning Management System solutions. It also has been ranked at 6th place in Capterra's Top 20 Most User Friendly LMS Software report.
GetApp, the premiere Cloud-based business apps marketplace, creates its quarterly rankings of the top Cloud-based business applications using a proprietary methodology that takes into consideration multiple factors about each reviewed software product. These factors include user reviews, feature sets, available integration options, mobile clients, media presence, reliability, performance, and security.
"As one of the top 25 LMS solutions in GetApp's ranking, eFront has shown its strength in its positive user reviews, software integrations, and its security. Notably, an average user rating of 4.8/5 has contributed 12 points to its overall score of 44, solidifying eFront in 14th place for this quarter's ranking." , GetApp's editor Suzie Blaszkiewicz wrote.
eFront has a consistent presence in top LMS rankings, and was featured in GetApp's Top 25 LMS app listing for 2015, among other placements.
Universally praised for its combination of powerful TDS/LMS features and renowned user friendliness, eFront has also been awarded the 6th spot in Capterra's latest LMS Software report.
Capterra, the hugely popular website for business software reviews and guides, awarded eFront the 6h place in its Top 20 Most User Friendly LMS ranking.
"We are very excited about the continued recognition our software receives from both users and industry pundits and reviewers, and we're especially proud that our revamped and rewritten offering, eFront, already ranks with the best TDS and LMS solutions", Epignosis CEO Athanasios Pappagelis stated on the new accolades of the eFront platform.


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Suncoast (Fla.) Riviera Beach High School's Devin Hester says he won't make a final college decision until "around Jan. 20," but every indication he gives is that Miami will be his choice.
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Raimundas Malasauskas
Raimundas Malasauskas was born in Vilnius; curates in the world; writes occasionally.
Jump to navigation
Raimundas Malasauskas was born in Vilnius; curates in the world; writes occasionally.
Katherine Manthorne is Professor of Art History, Graduate Center, City University of New York. She focuses on hemispheric dimensions of American art, exemplified by Traveler Artists: Landscapes of Latin America from the Patricia Phelps de Cisneros Collection (2015) that she edited.
Cinthia Marcelle (b. Belo Horizonte) lives and works in São Paulo and graduated in Fine Arts from the Universidade Federal de Minas Gerais (1996-1999).
Mauricio Marcin Álvarez (Tapachula, Mexico, 1980) works in the Museo Experimental El Eco as a curator and researcher. In 2015 he co-founded Aeromoto, a public library specializing in contemporary art.
Luis Mata (Porlamar, Venezuela 1990) is a multidisciplinary Venezuelan artist with a degree in fine arts, and a minor in sculpture (UNEARTE 2007-2013).
Roberto Mata is a self-taught photographer.
Benjamín Mayer Foulkes (Mexico, 1966) is a psychoanalyst and theorist who combines clinical work with the impulse of institutional, cultural, academic and editorial initiatives.
Esperanza Mayobre is a visual artist who lives and works in Brooklyn, NY.
Cuauhtémoc Medina is currently Chief Curator at the MUAC Museum in Mexico City.
Solita Mishaan was born in Caracas and has dual citizenship from Venezuela and Spain. She has a degree in Literature and a degree in Law from, respectively, the Universidad Católica and the Universidad Santa María, both in Caracas, and has a Master's in Political Science from McGill University in Montreal, Canada.
Luis Molina-Pantin lives and works in Caracas.
Dr. Montgomery is the Patricia Phelps de Cisneros Professor of Modern and Contemporary Latin American Art and Distinguished Lecturer at Hunter College.
Joanna Montoya Robotham is the Neubauer Family Foundation Assistant Curator at the Jewish Museum.
Pilar Moreno (Panama) is a visual artist and psychiatrist. Her work in drawing, painting, collage, and animation explore different themes with a common interest in the social and political realms.
Sergio Muñoz Sarmiento is an artist, writer, teacher, and lawyer interested in the analysis of property and structures, in both tangible and intangible forms, through legal and cultural discourses and practices.


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Blackhawks honor Chicago Cubs World Series Win Before Game
Phil Kessel to Sidney Crosby: 'F*ck You, WTF Are You Yelling At Me For' (Video)
by: Darrelle Lincoln On Sunday, November 27, 2016
On Saturday, the Pittsburgh Penguins were taking on the New Jersey Devils. With the score was tied, 3-3, Penguins star Sidney Crosby skated over to teammate Phil Kessel to have some words with him.
Kessel was having none of it. He basically told Crosby to "f*ck off" immediately.
'F*ck You, WTF Are You Yelling At Me For'
"Fuck you, what the fuck are you yelling at me for." https://t.co/tIxKJJG9HB
— Evgeni Malkin's Ego (@EvgeniMaIkinEgo) November 27, 2016


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Book by Plume Books
Please, let me know via email when the new review on this product is available.
"The Big Bang" is a great, comprehensive book that is written in a blunt and honest way that includes a lot of sexual techniques as well as a lot of sexual safety information. The techniques are pretty basic, but if you haven't read a sexual education book before, they will be very helpful to you.
Although this is full of information, it is far from reading a textbook or scouring the internet- some of this information may not even be found with either of those resources. Intimacy should be fun and at some times it is downright silly! Nerve captures this emotion and writes their information in a relatable and innately human way.
If you need to buy only one sex book in your life, get this one. The Big Bang covers a wide variety of sexual topics in a good amount of detail. I have read a few sex book and this is my favorite by far. If anything, buy this book for the "Sex for Winners" part, it has information that every person should know.
For those looking for a good resource to have on the shelf, this book would be phenomenal. If you already have a general text you depend on, I wouldn't recommend this book as it does not offer a whole lot of new information.
The best thing about the book, however, is the way the information is delivered. It's like having one of those tell-me-your-secrets conversations with your very best friend. It's funny and fresh, and presents the point of view that sex is healthy, natural in all its forms, and restorative to the soul.


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VideoHive The Stormy Logo 135259
After Effects Project \ Logo Stings \ Nature
Stormy \ Perfect \ Template \ Please \ Project \ Version \ Audiojungle \ Seconds
After Effects Project - The Stormy Logo 135259 by djordjevla @ VideoHive
After Effects Project \ Logo Stings \ Nature
Watch it on VIMEO
Hello !
New AE Template perfect for your LOGO opener. Rain, lightnings, stormy weather are perfect power elements in this project which you can use for some trailer promos, video productions intros, presentations, product showcases, portfolios and more.
There aren't any 3rd Party Plugins !
- FULL HD Project, but there are finished compositions for other lower resolutions you need.
- LOGO place
- Two editable text layers
- HELP file
- Duration: 20 seconds.
Audio is not included but you can purchase it from.
Please send me a message if you find any problem with this template, I will help as soon as possible !
Please, don't forget RATE !!!
You will also like my other projects.
<http://s3.envato.com/files/1435617/preview-image.jpg" />
After Effects Version: CS4; Resolution: 1920x1080; File Size: 191kb.
Clean Business Slideshow; Rain Stormy Opener; Christmas Greeting Holidays Card 2015; The Cinematic Stormy Trailer; The Modern Vintage Gallery; Business New Year Logo 2015; Christmas Background Pack.
Keywords: blue, electric, horror, intro, lightning, logo intro, rain, rainy, scene, storm, stormy, stormy scene, thunder, thunderstorm, white.


text: So I wore my AC Ruby mini city to a wedding on Saturday night, it was a pretty swanky wedding and everyone wore black tie and red accents. I didn't know anyone but the couple getting married and the girl that was my date, so I wasn't willing to put my purse down. And luckily I didn't. I was grabbed by 6 women (my friend was just totally freaked out by this time) and told that if I leave that bag unattended they will steal it and run for the hills. I have never gotten so many compliments. The "crappy" bag I retired in favor of this got TONS of them because people loved how simple it was, but this is just ridiculous! Just makes me love it more.


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Blaine received an update on the ongoing effort led by the city to revitalize the local economy.
On October 11, company principal Tom Beckwith of La Conner-based Beckwith Consulting presented results from surveys released to Blaine residents and library users in July.
"We're very interested in understanding what the city needs to do," said city manager Dave Wilbrecht. "This is about what the residents and citizens want."
The presentation took place during a monthly meeting led by the Blaine Economic Development Advisory Committee, which was created in an effort to address the economic needs of Blaine years ago.
The city partnered with Beckwith in early June. Since then, 21 interest groups have been approached by both entities to develop an economic plan for Blaine. The city also released three community surveys in July to gauge the needs and interests of residents, visitors and library users in the community.
On Tuesday, Beckwith revealed that a total of 420 residents responded to the resident survey, which is now closed. Most respondents reported living in central Blaine.
For most, recruitment of downtown businesses – including restaurants, retail and hotels, for example – was of crucial importance in revitalizing the local economy.
"Your anchor is your downtown," Beckwith said.
Beckwith also went over results received from the, now closed, library survey. A total of 223 responded to the survey and agreed that renovating or expanding the facility to include public restrooms, a children's room, teen room and computer room would improve the space for the community.
Blaine's Economic Development Advisory Committee was also presented with a number of different conceptual designs to update or expand existing community spaces. Currently, cost and methods for completing identified projects are still in the works.


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Kansas teachers have done wonderfully under difficult conditions. The average cost of education K-12 in Kansas is more than $9,000 per student per year. Yet, Kansas ranks 48 out of 50 states for getting resources to the classroom. You're paying too much and they're not getting enough. The kids deserve better! At the college level, only legal residents should be eligible for instate tuition; we cannot do otherwise with our education funds.
Source: http://vote4fitzgerald.com/issues.html


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Once upon a time it was possible to be anonymous on the Internet. You were free to browse poorly-made websites and say whatever you wanted without fear of reprisal or backlash.
But today, the Internet has become the universal tabloid.
During the days prior to the Internet (gasp, who remembers what that was like?) a person could do or say something stupid and it would remain a joke between them and their friends.
Not now.
If you fall over in the street and are unlucky enough to be filmed doing so, chances are you will find infamy somewhere in the dark corners of the Internet. Without you even knowing, you could have been the subject of entertainment for millions of viewers who all saw you fall over in the street.
Viral videos such as these will move on and be forgotten about within days. Your office will suddenly receive a new video, perhaps a cat running in to a screen door, and your street-falling antics will become history.
The Internet loves to find something to complain about. The video of you falling may have given them a chuckle for a minute, but if you had been pushed, then the longevity of your fame may be extended.
The story of Mary Bale is absolute testament to this. One day in 2010, while walking through her neighborhood, she saw a cat on a wall. Mary fussed the cat innocently enough, but out of nowhere she suddenly opened a trashcan and dropped the cat inside before carrying on down the street.
Unluckily for Mary, she was caught on camera. While the cat was later found in good health, the same could not be said for Mary. Once the video hit the Internet a worldwide hate campaign began, labeling Mary as 'evil' and 'twisted'. She lost her job, became the arch nemesis of cat lovers everywhere and received countless death threats.
While Mary's actions are certainly not to be condoned, she didn't exactly invade Poland.
This is how the Internet, with a little help from the tabloids, comes into it. While under normal circumstances a story such as this would have made little more than an afterthought in a local newspaper, Mary Bale's cat trashing actions caught the attention of the masses and within hours she was trending on Twitter and the focus of hundreds of Facebook groups (a huge number of which still exist).
That mob mentality had managed to turn a mild-mannered old lady in to one of the most hated people on the Internet. Such a mindless, silly moment had instantly banished her to a lifetime of internet infamy.
Then there is the story of Charlie Morgan, a ball boy at a soccer match in the UK. Charlie was unlucky enough to hold on to the ball a little longer than the players would have liked during a particularly tense final few minutes of a match. As a player kicked the ball from Charlie's grasp and subsequently dismissed from the game, Charlie is suddenly skyrocketed in to internet infamy and gains 100,000 Twitter follows in just three hours.
The ubiquity of the Internet, and the human desire for something to ogle, means these relatively minor incidents are catapulted on to our screens for all to see. With social media being a major part of our every day lives, you will be hard pressed to find somebody who doesn't at least have an account. Internet anonymity is becoming rarer by the day, so if you say something a little risqué and it is picked up by the wrong people then you may find yourself the butt of the joke.
Professional boxer Curtis Woodhouse was once reported to have hunted down somebody who had goaded him on Twitter and went as far as tweeting images of the streets he was prowling and threatening to knock on every door until he found the culprit. Naturally, internet infamy followed the perpetrator.
But it isn't always news that makes its way to social media – sometimes it can be the other way around. It is now commonplace to see celebrity e-scuffles make headline news, and even more frequently we're reading stories about celebrities and their encounters with 'trolls'.
It is these so-called 'trolls' who so often spread the vitriol to begin with, and sometimes their propaganda can become fact. Justin Bieber had to call out to his fans as trolls had succeeded in trending '#cutforbieber' and certain die-hard 'Beliebers' had gone as far as believing it was true and tweeting pictures of their own evidence. Needless to say, those fans gained instant notoriety online.
It is becoming increasingly more frequent for companies to filter job applicants by searching social networks. The last thing you need when applying for your dream job 5 years down the line is for somebody to Google your name and saw you once dumped a cat in a trashcan.
Then you'd wish you simply fell down in the street.


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Alright! Intel powered tablets are making their into markets thick and fast. Adding to the list is the Micromax Canvas Tab P666 tablet coming out with 3G connectivity via SIM card slot means this is one of the Kitkat voice calling tablets.
Micromax Kitkat Voice Calling Tab
This Micromax Tab P666 is equipped with 8 inch IPS touchscreen display and powered with 1.2 Ghz dual core Intel Atom processor and PowerVR SGX544 GPU.
This tables comes pre-loaded with M! Games, M!live, Bookmyshow, Hike messenger, SwiftKey, Dr. Safety, Opera Mini Browser and more.
Micromax Canvas Tab P666
|Display:8-inch 1280×800 touchscreen display
|1.2 GHz dual-core Intel Atom (Z2520) processor
|GPU:PowerVR SGX544
|Software: Android 4.4 Kitkat OS
|SIM Card Slot: Yes
|Main Camera:5 MP rear camera with LED Flash
|Front Camera:2 MP front facing camera
|Storage: 8 GB Internal + Micro SD card slot support up to 32 GB
|Connectivity:3G HSPA, Bluetooth, WiFi tether, WiFi,Bluetooth
|Battery:4400 mAh Li-ion battery
|GPS, FM Radio, 3.5 mm audio jack
Price, Availability
Micromax has priced Canvas Tab P666 in White and Black color variants priced at Rs 10,999 from November 29, 2014.


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There is no account?
The kit contains: color cross stitch pattern, Aida 16, mouline Anchor – 38 colors 6 of which are mélange colors and a needle. Stitching techniques are two and one threads with cross, semi-cross and "back needle" stitch.
Size: 36.5x32 cm
© TM Charivna Mit 2018, all rights reserved


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I've recently been asked by a friend to write about what it is we can do to change what's happening in our government. I'm not talking just about Trump for president, but the over 200 years of control the Republicans and Democrats have had over our government. Even though the Democrats have become more progressive, they do this to survive as a party, and their progressive agenda is largely based on social institutions like marriage and health care. Great causes, of that there is not doubt, but they aren't looking to make big changes to the economy or our investments in war.
In addition, changes in the Democratic Party don't help right now, under a Trump presidency. No matter what happens within the Democratic Party in the next four years, Trump will still be president, and at least for the next two years, both the House and Senate will be controlled by the Republicans. So, I'm not interested in looking there for change, nor do I believe I'll find it there. The Democrats to me are the true turncoats. They support what's popular. What do the polls say? People support gay marriage. Ok, we do, too. (Hillary Clinton is probably the most public offender of this type of Democrat.)
There have been calls from Republicans and Democrats to come together, to work within the system, but working within the system is what got us here in the first place. And it's insulting to say that we haven't been. Over 121 million people participated in the system this November, and only one party will have control of the government and only two parties have any real representation. Last I knew, there are more than two kinds of people in America.
But it's more than that. As Trump said, the system is rigged, but not against him. It's designed to keep people out. It may not have been designed by one or even a small group of engineers, but over time, our political system has maintained a two parties and actively seeks to keep other parties out.
Ballot access is one of the ways in which this is done. Each state is different, but getting on the ballot as a third party candidate is intentionally very difficult, and in some states close to impossible.
Holding emergency or even secretive sessions obstructs democracy and keeps majority groups in power (I'm looking at you Wisconsin legislature). Even if we agree with the reason why a group of politicians decided to hold a last minute and almost secretive session in order to vote on a controversial bill and even though they can technically do that, that's obstruction to the democratic process.
Delaying a vote or action on an item until after an election isn't good democracy either, but seems to be well-used tactic to maintain seats during an election year. There was a lot of silence regarding the DAPL from Washington until after the election. And that silence served it's purpose. Republicans and Democrats don't want to lose votes to third parties because they want to approve the pipeline. I'm not going out on a limb here to say that they probably do want to approve it.
Lobbying is a dangerous practice where corporations and special interest groups work to influence the vote of our representatives. It's a bit of a catch-22 because you want special interest groups that you care about to be talking to your representatives but not others. What's scary is that the wants of corporations and special interest groups become more influential than that of a representative's constituency. Additionally, lobbying makes Republicans and Democrats stronger via campaign contributions and other funding sources that third party candidates don't have.
Another example of a defunct system is politicians using their influence in government for personal gain. They hand over government contracts to their own businesses, to the businesses of friends, etc. Because current politicians can make money off of their political influence, they can use that money to maintain their position in politics; thereby, keeping third parties away from the bargaining table.
So working together within this system makes no sense. The system has to change. That doesn't mean throwing out the Constitution, but it does mean a complete overhaul which includes more control over our representation in government with things like term limits, ending or greatly restricting lobbying, and forcing politicians out of deals that are a conflict of interest (like many money off of a government contract). Republicans and Democrats will not make these changes because they are also profiting from war, deregulation of banking, favoring their own businesses in government affairs, etc.
It's hard to think about these things and not think about a total armed revolution. But I still believe that the majority of Americans, even pro-Trump Americans, don't want that. I know I don't. But how can you revolutionize an entire system without a large-scale revolt?
Don't under-estimate the power of protesting. Directly, it does not change policy, but indirectly, it can be powerful. Large numbers of people converging on a place or marching in the streets gets media attention and puts pressure on politicians. It also gets people talking. People who might not be informed on a topic become inspired to learn more after learning about large scale protests. Protesting is a long term commitment, though. Politicians are counting on you to run out of steam quickly and not commit long term to your cause.
Boycott large corporations as much as you can, especially those that lobby politicians. This can be very difficult especially in rural areas where your only grocery store is literally a Walmart, but when you make politics about money, politicians listen. Remember that politicians either have stock in corporations or are owners of large corporations and don't want to lose money. So they are likely to start listening if they are losing money or if lobbying groups that support them are losing money. It also serves to weaken corporations that should have no say in government in the first place.
Sit-ins and strikes
Organize and participate in sit-ins and strikes. This is like a two for the price of one deal. You'll get media attention, and sit-ins and strikes usually cost companies money. A sit-in can be organized on public or private property, but do so knowing that you could be arrested for trespassing. Strikes traditionally have more to do with workers' rights, but their scope has expanded. This year in Poland, women all over the country walked out of work to protest an anti-abortion bill. If half of your workforce walks out of the job, you bet people are losing money, and politicians are listening when businesses lose money.
Civil disobedience
Sit-ins and strikes are kinds of civil disobedience. Other types are obstructing roadways, like with some of the BLM protests; blocking entrances into places of work (again businesses losing money); refusing to follow a law or a rule, like standing for a white person on the bus. Civil disobedience on a wide scale has been very effective, but usually it requires breaking a law. Some laws, however, should be broken.
If you're not ready to take some of the above steps or if I haven't convinced you to work outside of the system, here are some additional ideas. Some of the most successful social and political movements actually coordinated efforts from within and outside of the system, so these are worth your time. Also remember that when you disrupt the system, you change the system.
Support ballot access for third party candidates
Because our two party system is so corrupt, it's time to seriously consider third party candidates. Many other democratic governments have 3 or 4 major parties. And yes, their systems aren't leaps and bounds better than ours, but they are largely considered to be better to some degree (some more than others). And it allows for more voices of the populace to be heard, which can lead to a greater effort in collaboration. One of the things we want to avoid is one party controlling more than half of Congress. Even if you can't 100% support a third party, find one that's close. Chances are you don't 100% support the Republicans or Democrats either. This also means taking the time to sign petitions that get third party candidates on state and local ballots. This is a very important step and should only take 15 minutes of your time.
Vote for third party candidates
So once you have that third party candidate on the ballot, you need to also vote for him/her. Again, in our current system, one party has more than half the seats of Congress. No one viewpoint should have this much say. Third party politicians can change that. Even with one viable third party, the chances of one party having control of a government body is very small.
Join a non-profit
Even if it's just to give money, do it! Pick any organization that is near and dear to your heart. The ACLU, a local homeless shelter, an organization that helps settle immigrants, scholarships for minority students, etc. I encourage you to pick an organization that advocates for minority groups because they are the ones that will be the most hurt by Trump's administration and the Republican controlled Congress. Many organizations also offer easy ways to contribute your time. You don't have to become a board or committee member to work with a non-profit.
Write letters to your representatives often
You'll have to do your due diligence and stay informed about votes coming up and then write to your representatives about how you think they should vote and why. The easiest way to stay updated is to join an organization that pays attention to bills under consideration and puts that information in a newsletter or email list. Don't forget about your representatives at the state and local levels, too.
Lastly, if you want what it is you're doing to gain and maintain momentum, encourage others to join you. Be specific about your plans and be specific about how you want people to get involved. I know that for me when people ask me to help and they're not specific, it feels overwhelming. For example, consider these two requests: Can you help me out at the conference? and I need someone to register people as they come in for the conference. Can you help me with that? The first request is too open-ended. It sounds like you could be doing any number of things for an unknown amount of time. But the second one is more specific. I'd be more likely to respond to the second request than the first one just because I'm rarely available all day to help with something and because I want to know what I'm committing too.
So many groups are mobilizing, so you don't have to start from scratch. Feel free to add some of your ideas in the comments.