text:
Blades fans were predicting victory this morning as they prepared to cheer on Sheffield United in their bid for glory at the FA Cup semi-final.
Bramall Lane was a sea of red and white as fans sporting wigs, football shirts, face paints and even a tin foil FA Cup lined up for their lift to Wembley.
Dozens of coaches, many decked with flags, set off at 8am, due to arrive in London with plenty of time to soak up the atmosphere before kick-off at 4.07pm.
One dedicated supporter who had a tough call to make was dad-to-be Daniel Fletcher, aged 31, whose wife, Suzanne, aged 28, is days away from giving birth.
Daniel, of Dronfield, said: "I'm hoping for a win today but I'm also hoping that my wife doesn't go into labour!
"She's not far from her due date so I had to make a call. That's dedication to the Blades!
"She is two weeks away from her due date so if we get to the final I'll be in trouble if I went down again. I've been and bought the baby her first football kit though."
Daniel's dad, John, aged 59, added: "I hope we're going to win and we have a nice day. We're very much behind them - I'm hoping for 2-1 to us."
Meanwhile, other fans were a little tired after getting up at the crack of dawn - but said it's worth it for the chance to see their team in action.
"We're tired because we woke up at 4am for no reason, but I managed to get back to sleep until 5.30am," said James Daine, aged 21, of Arbourthorne.
"We've been dedicated all through the season. We had a bad start and didn't pick up many points but everything is looking up now and hopefully the lads can bring it home.
"I'm hoping for a good atmosphere and a lot of happy Blades fans. I'm hoping for a 2-1, with Murphy to score first."
Coach steward Lee Wilks, aged 30, of Swallownest added: "I got out of bed, I've had a sandwich and an energy drink and now we're ready to get on the coach.
"I'm going to say it'll be a 1-0 victory, I think it's going to be Brayford that scores first.
"Blades fans are just amazing. We're taking 32,000 fans with us so it's really amazing support for the team. I hope we get to play in the final against Arsenal and qualify for Europe."
Young fan Susan Wilkes, aged ten, of Arbourthorne said: "I'm hoping Sheffield United win so I can go to another game. I've been a fan for five years - I was watching Sheffield United with my dad and they were really good so I decided I was a fan. I think Sheffield United are going to win 2-1."
Dorothy Howe, 68, of Duke Street said: "I first became a Blades fan in 1975 when I met my husband. He helped build the South Stand. We're hoping for a win. This morning I've been up since 4am doing my hair! You can't beat the atmosphere."
Mark Pantlin, aged 47, from Rotherham, said: "We got up at the crack of dawn, got dressed, stopped at McDonald's for breakfast and now we're here. It's great to start the day with such a nice atmosphere.
"We're hoping for a win, obviously. I think we can make it 2-1 easily, but if we don't then we don't. After the way we started the season, we were a bit poor but we have pulled it around and this is the icing on the cake."
Going to Wembley or cheering the Blades at home? Send us your 'selfies', other pictures, short videos, good luck messages and comments.
With 'selfies' add out hashtag #thestarselfie
Email: firstname.lastname@example.com
Twitter: Tweet to @SheffieldStar or @TheStarBlades
Facebook: www.facebook.com/sheffieldstar.
Instagram or Vine: Upload to your accounts and use #thestarselfie.
* Follow us on Twitter for live updates @SheffieldStar and @TheStarBlades - we will also be using the club's official hashtags #twitterblades and #sufc


text:
- Age / Gender:
- n/a, Unspecified
- Location:
- Location not disclosed
- Joined:
- 9/11/16
- All Stats >
User Statshot
- Community Stats
Level 3 Blank Slate
Normal Whistle
Ranked as Civilian
Contact Info / Websites
Recent Game Medals
In your own time 10 Points Which is in fact the worst time Medal Stats.
SECRET MEDAL 25 Points Unlock this medal to see it's details. Medal Stats.
Fruitasic 5 Points Your so smart, I wish I was smart as you, how can I be smart like you? Medal Stats.
Sorry 5 Points That's all I could do Medal Stats.
Idiot 5 Points How exactly did that one change? Medal Stats.
There's a water in the trash 25 Points Finish the trash level. Medal Stats.
There's a crate in the shark 25 Points Finish the shark-crate level. Medal Stats.
I wanna eat you 10 Points Finish the shark level. Medal Stats.
That's crate 5 Points Finish the crate level. Medal Stats.
Total Medals Earned: 9 (From 2 different games.)
Latest Audio Submissions
Latest Favorite Audio
|The Third
|Dance Song

subset: commoncrawl


text:
Blogs I Follow
- Lore Graham
- bumping into firecrackers
- The Hungover Widow
- Stone Wave Recipes
- Kiwi Girl attempting Italian
- Shapely Prose
- Jane Austen's World
- Brooke: Not On a Diet
- Families for Justice as Healing
- Reign Fashion
- Kahn's Corner
- It's Not a Match.com
- The Frugal Feminista
- Sequins and Sweets
- Welcome to TaraLand
- Mother Nature
- poetspiratesandeverythinginbetween
- A Neurotic Glamour Girl's Weight Watchers Experience and Fitness Adventures
- My New Roots
- Learn Italian with Lucrezia
Most Popular Posts
- The Five Stages of Dating an Italian Man
- Cliff Jumping (aka My Butt Hurts)
- What Italians Drink: Sangue di Giuda
- About
- A Trip to The Haunted Island of Poveglia: Part One
- Rory Gilmore's Reading List
- What's up, Kansas City!!
- The Vampire Museum, San Marino
- Cultivating Moss (Project 365 Day 23)
- Ca Bruzzo Winery
Tag Archives: Vienna
Christmas in Vienna
Posted in Uncategorized Tagged Austria, Christmas, Holidays, Photography, Travel, Vienna 2 Comments
Stained Glass
Dad and I walked what felt like the entire length of Vienna today. Our goal was to see each Christmas market as we made our way to the Belvedere museum (more on that later). During our trek, we stopped in one … Continue reading
Posted in Uncategorized Tagged Austria, Churches, Life, Photography, Travel, Vienna Leave a comment


text:
UNHCR is not responsible for the content and availability of non-UNHCR websites. Content displays in a new window.
Minister for Immigration and Citizenship v. MZXPA
29 February 2008 | Judicial Body: Australia: Federal Court | Document type: Case Law | Topic(s): Independence of judiciary - Persecution based on political opinion - Witnesses | Countries: Australia - Lebanon


text:
A custom patio is a place where you can relax, entertain and escape from it all — without leaving the comforts of your own home. Your custom patio can expand your living space to the beauty of the outdoors. Imagine mornings watching the sunrise while drinking your morning cup of coffee or watching the sunset with your family and friends in the evenings on your new patio.
The Problems with Do-It-Yourself Paver Patios
Perhaps you've thought of attempting to build your own brick paver patio. Before you start, it's important to know what you'd be getting yourself into before you buy even one brick. The process of building brick paver patios is not an easy one. Steps include laying foundation, packing it with materials like sand or gravel and properly laying the bricks. If you don't have the know-how, you could end up with an uneven patio unlikely to stand the test of time.
Receive Customized Attention for the Best Results
At Shearer Patio & Landscape Services, we take great pride in building a backyard paver patio that meets your exact specifications.
While most landscaping companies will design and install your brick paver patio, we do more. We take the time to understand how you want to use your new outdoor space. By sharing with us how you envision your custom patio, you can benefit from our expert advice and learn how to best achieve your dream.
The design team at Shearer Patio & Landscape Services will work with you throughout the entire design and construction process. We will create a custom patio design that will meet your unique needs, landscaping and property layout. We'll review your options with you to help you make the best design choices. Our professional craftsmen will then build you a gorgeous patio — whether you want a brick paver patio or stone — that provides function, durability and stability.
Create Custom Brick Patios, Paver Patios and More
When it comes to custom patios by Shearer Patio & Landscape Services, you aren't limited by material either. We offer a number of custom patio options. From custom brick paver patios to eye-catching custom patios made of flagstone, we do it all. Your new patio can be uniquely "you" while complementing your home's outdoor décor.
The Best Custom Patio Design
When it comes to the design and construction of custom patios in the Columbus, Ohio area, Shearer Patio & Landscape Services provides excellent service and unprecedented client satisfaction. With extensive experience in custom patio design, Ohio homeowners and businesses turn to us for the best results.
A well-constructed brick paver patio not only adds beauty to your home and serves a variety of useful functions, it can also add to your home's value. According to a study conducted by the American Society of Landscape Architects in conjunction with Money Magazine, a patio's recovery value can range from 100 to 200 percent when you sell your home. In a time where homeowners are doing all they can to squeeze every penny out of their home's value, constructing a paver patio can be a sound financial move. And even if you decide to stay in your home, you'll enjoy the benefits of your patio for years to come.
We're known throughout the area for our meticulous work, and our team takes pride in every job we do. In today's world where time is pressed and corners are cut, we stand out. We take the time to do it right, and we use only the finest materials. Our hand-crafted custom patios reflect our mission to provide the area with the best landscaping solutions, so you can enjoy enhancements to your outdoor spaces that last.
Transform Your Outdoor Space
In addition to custom patios, we offer a range of landscaping services. Transform your outdoor space further with a custom pergola, water features, outdoor lighting and more. With Shearer Patio & Landscape Services, you can create an outdoor space that combines functionality with inspiring beauty.
Get Started Today on Your New Custom Patio
No matter where you are in the process — whether you're just thinking about the possibility of a custom patio or you're ready to start your brick paver patio project today — we can help. We'll review your goals, outdoor space and budget to provide expert recommendations on the best way to transform your outdoor space with a custom patio.
Give Shearer Patio & Landscape Services a call today at 614-889-9981 or contact us online to start creating the patio of your dreams that will bring you years of enjoyment.
Shearer Patio & Landscape Services provides brick paver patio design and construction in the Delaware, OH area and custom patio services in the following Ohio cities: Columbus, Delaware, Dublin, Gahanna, Galena, Hilliard, Lewis Center, Marysville, Powell, Upper Arlington, Westerville and Worthington.


text:
This Float Modular Wall Unit by M Furniture offers a contemporary approach in design with a slight classic flavor. Durable wooden construction gives this set its ultra modern exterior. The glass base renders an incomparable uniqueness.
- Collection: Float
- Modular Wall Unit
- Finish: Timber Chocolate
- Durable wooden construction
Modular Wall Unit: 62 W x 15 D x 72 H
Looking for quality furniture, designed and built with taste and comfort in mind? Our collection of J&M Furniture is the finest solution for your modern home. We offer products for living room, dining room, bedroom, home offices at reasonable prices that doesn't affect quality of furniture. The company works since 1993 and manufactures products in unique modern style to satisfy requirements of today's customer.
Write a reviewYour Name:
Your Review: Note: HTML is not translated!
Rating: Bad Good
Enter the code in the box below:
A wonderful way of creating a focus and personality, the shelving can display treasured items or photographs and books. The first step to organize the space, our mid century and contemporary shelving units are customizable and versatile. They are made of different materials like metal, solid wood or wood veneer and have unique and interesting design with rich textures and various surfaces. Available in a variety of shapes, sizes, finishes and styles, you can use our shelves in many areas of your home from living room to bedroom.
Evaluate great storage and display solution in any room where storage is required without sacrificing style with the shelving from ModernManhattan.com!


text:
Every year on the International Day of Peace, the United Nations calls on the people of the world to remember their common humanity and join together to build a future free of strife. It calls on all of us to observe a day of global ceasefire and non-violence.
Never Again Rwanda (NAR) in collaboration with the National Unity and Reconciliation Commission (NURC) today organised a youth exchange with Parliamentarians, legislators and policy makers, to provide youth with a space to express their peace-building needs, initiatives, as well as discuss challenges to peace and how to mitigate them. For the 3rd consecutive time, this year NAR gathered around 400 youth from all over Rwanda representing different universities, schools and civil society organizations involved in the promotion of peace. The celebration started with the watering of the peace tree by the officials at the parliament garden as the youth sang songs that mobilize citizens to promote peace, unity, reconciliation, patriotism and hard work.
There were several speakers in attendance; Right Honorable Mukabalisa Dionatille, Speaker of Parliament, lower chamber; Hon. Venantie Tugireyezu, Minister in the office of the President; Hon. Papias Musafiri Malimba, Minister of education; Mrs. Julienne Uwacu, Minister of sports and Culture; Mr. Stephen Rodriques, One-UN representative; Mr. Fidele Ndayisaba' the National Unity and Reconciliation Commission (NURC) Executive Secretary; Mr. Eric Mahoro, the Programs Director at Never Again Rwanda (NAR).
Honourable Tugireyezu Venantie, Minister in the office of the President of the Republic of Rwanda was happy to gather with the youth since they are the future parents and need to instil the right attitude for the future generations especially concerning peace; "We cannot replace peace with anything. We tasted a situation where there was no peace, and we know what it feels like. We also tasted the situation where there's peace, and we are feeling it," she said, before inviting the Speaker of Parliament, Chamber of Deputies, Right Honorable Mukabalisa Donatille, to address the audience.
In her official opening remarks, she mentioned that Rwanda's unique testimony about the absence of peace for a long time gave us an experience and always makes us think each day that there's a lot we can do to make our people better; she emphasised that Rwanda has experienced both peace and war and therefore the citizens understand the difference between the two scenarios", regarding youth, she mentioned that "it is through the youth that we can achieve all this given that they make the majority of our population. We undoubtedly believe in them and their efforts to build a better future for our country".
Furthermore, the values of Rwandans include protecting the peace that they enjoy today by fighting divisionism. She welcomed youth at the parliament being their house, be it in such meetings or for other parliamentarians sessions.
After the opening remarks, there was a presentation by Dr. Jean de Dieu Basabose, an expert on peace sustainability and a documentary film "Intambwe igana ku mahoro" put together by Never Again Rwanda, showcasing the path to peace.
A plenary session was then held questions and comments from the youth, followed by answers from the panel of experts, government officials and civil society members. The major issue raised by youth was the need to invest in peace centred and critical thinking education as a priority.
It was discussed that the lessons on peace start at the family level since that is the foundation through informal education, which is going at a later stage to be complemented by formal education.
Among the key recommendations from the exchange, youth committed themselves to become peace ambassadors and fight Genocide ideology, as well as combat affecting them such as child trafficking, drug abuse and terrorism. They called for the consideration of peace studies and critical thinking in the formal education curriculum, and for a partnership at all level to provide youth with opportunities to engage in peace building initiatives.,
As co-organiser, Mr. Ndayisaba Fidele, the National Unity and Reconciliation Commission (NURC) Executive Secretary encouraged the youth to focus on being peace actors since they are the intra generation bond. Eric Mahoro, the Programs Director at Never Again Rwanda (NAR) appreciated the Rwanda Parliament for consistently hosting the youth on the International Day of Peace for 3 consecutive years. He reiterated that the platform gives the youth a chance to interact with the parliamentarians, to give their ideas and to influence relevant policies as well.
In his closing remarks, Honourable Papias Musafiri Malimba, Minister of Education stressed that the culture of peace is crosscutting and has to be embedded in the national curriculum of education as a culture, not a detached course. He called on youth to strive for peace from their families first.
The youth-parliamentarians exchange ended with the youth singing more peace songs as they interacted and exchanged ideas.


text:
Bracken's text read, "Have you heard of Mac Sabbath? Freakin' ridiculous, they dress up as McDonald's characters and do Black Sabbath covers."
"Do you mind if I use that?" was the only response necessary to such a promising inquiry.
And put some stank on "promising."
Mac Sabbath is a two-year-old Los Angeles-based quartet of traveling Black Sabbath channelers/interpreters who dress up as loose interpretations of the characters from a McDonald's McDonaldland cartoon promotional campaign that began in the 1970s. This conceptual "Drive Thru Rock" act geared up in the Nashvillian staple venue Exit/In Monday, March 14, during the last leg of its hilariously copyright-law-fragile Rock Sham Shake Tour, appearing to have been piled up in the back corner of their tour bus for a couple of months coated in a film of used peanut oil while maintaining the level of edibleness as their chosen fast-food chain's chicken nuggets would have if said chicken nuggets were fried under the same circumstances.
The extra cheese seemed effortlessly added by Mac Sabbath, and the attentive Exit/In crowd ate it up.
Before the ridiculousness, a steadily growing crowd of intrigued Middle Tennesseans were freshly primed for the evening's fitting rock-heavy mentality by local horror-rock quintet The Creeping Cruds, which landed the opening gig with a little bit of luck mixed with some Cruddy gusto at an opportune moment, according to the Cruds' drummer, Murfreesboro sweetheart and assault-bassist Horror Blood Hand Sammy Baker. The Creeping Cruds' vocalist, Wolfie, whose personalized Lemmy-inspired stage presence and loose comedic band direction acted as that fine primer for the audience's Mac Sabbath expectations.
Mac Sabbath's set was constructed behind a yellow-and-red-striped circus tent-style stage skirt hiding the view from the still steadily growing audience and teasing the imminent weirdness-to-come. Besides the stage skirt, only a few laser-eyed, smoke-vomiting Ronald McDonald heads-on-sticks effigies peered over the crowd.
They pulled their circus skirt down around 10 p.m. and, well . . . Mac Sabbath. Keep in mind these L.A. Black Sabbath enthusiasts are navigating a heap of copyright laws to avoid getting sued by McDonald's, but they are not afraid to rock your dipping sauces.
Upon the reveal, Mac Sabbath's immediate knee-slap appearance showed a satirical parody of three McDonaldland's characters already onstage. Sitting behind a drum kit of hamburgers was Catburglar, or the Hamburglar, made up as original KISS drummer Peter Criss. On electric guitar stage right stood Slayer MacCheeze, a character combining Joe Perry and Jimmy Page in their prime (with some Tony Iommi on top, of course), sporting a half-unbuttoned purple velvet shirt, tight black pants and wearing an oversized Mayor McCheese head tweaked with long silver Motorhead logo tusks.
Grimalice, the purple, seemingly restrictively bulky and heavily inebriated Grimace character, stood waiting stage left.
The fourth member of Mac Sabbath, frontman Ronald Osbourne—a demented Ronald McDonald crossed with a straitjacketed Ozzy Osbourne—slowly crept to the mic to shed his restraint and belt out the first tweaked Black Sabbath cover, and, yes, Mac Sabbath rewrote Black Sabbath's lyrics to include McDonald's fast-food lingo and menu item puns for a more McDonaldland-friendly environment.
Aside from Mac Sabbath's novel and increasingly popular traveling parody show, witnessing such a conceptual stage show is still somewhat fresh and, honestly, needed for our surrounding Middle Tennessee area (the closest local comparison would be nationally recognized Murfreesboro concept band Protomen, which started performing its Megaman-themed rock-opera act 16 years ago).
Starting out as just a joke, Mac Sabbath's popularity grew rapidly from a simple notice and a repost of their closed-captioned "Frying Pan,"("Iron Man") video by Black Sabbath itself, on the band's own website.
That tip-of-the-hat Facebook share was the serendipitous spark igniting Mac Sabbath's motivational pilot light as, in response, the four guys subsequently geared up in a timely manner for immediate West Coast and transatlantic touring as the new minimum-wage rags-to-self-worth-riches act, standing collectively as a figurehead for downtrodden young American fast-food employees.
Musically, Mac Sabbath sounds like what would be expected of a cover band fresh out of the garage. But the comedic glory of the grimy Mac Sabbath concept is what has carried it to widespread niche fame. The band takes every chance for a Black-Sabbath-combined-with-McDonald's pun, as exemplified by popular videos such as "Never Say Diet" ("Never Say Die"), "Para-Buns" ("Paranoid"), and "Sweet Beef ("Sweet Leaf"). All of that, plus crowd-pleasing shenanigans such as dumping buckets of confetti (and eventually buckets of McDonald's dollar-menu items) into the crowd, tossing about giant hamburger beach balls, and Ronald Osbourne pulling a 10-foot-long fountain-drink straw from his pants and having an audience member pour beer into it from the fourth row.
Osbourne displayed a genuinely enthusiastic mood, fueled in part by being in Music City. And, of course, the crescendo of their hard night's work, Slayer McCheez licking out that very well known, heavily fuzzed five-note McDonald's commercial riff as Osbourne nods his head, looking the crowd right in the eyes while singing "I'm Lovin' It" for the night's mic-drop finale moment. The crowd went crazy with hilarity as Mac Sabbath walked off the stage, leaving the room looking like a bar fight broke out at the Mickey D's next to your friendly neighborhood interstate exit.
To get a taste of what Mac Sabbath is all about, their reworked Black Sabbath videos (captions and all), merch and tour information can be found on Facebook, YouTube and officialmacsabbath.com.


text:
Can your diet help plan a twin pregnancy?
I posted in the wrong board before....!
I'm in my mid thirties and I am seriously looking after my fertility and my health to prepare for a healthy pregnancy when the time is right.
I've always dreamed about being a mother from a young girl, and I vowed that when I meet the right guy, it will happen. I also dreamed about having twins. I would love either gender and I really hope for a twin pregnancy with God's will. I think, in a way, i feel comforted by the fact that my first pregnancy will happen when I'm a little older and mature enough to handle this. I know there are so many things to think about with a multiple pregnancy, and how I would be considered "high-risk" but I just think focusing on the positive side of things is the healthiest way to approach this. So on to my question...
I will be happy with whatever pregnancy I'll have. Just to feel my baby grow inside me and then hold it in my arms is my biggest dream. However, even if I were to entertain the idea of having twins, aside from my age (mid-30s), could my diet help things along?
I've been reading a lot on this over the internet, and I've read over and over that a diet full of whole milk, dairy, sweet potato/yams, bananas, foods high with folic acid, taking folic acid supplements, eating avocados, oranges/juice, combined with being over 35, that this has played a big role in having a twin pregnancy.
Is this true? Can your diet help you conceive twins? I'd love any pregnancy, like I said, but I really would love to experience a twin pregnancy. I do not wish to go under fertility treatments to achieve this - I think it's too risky - but if this can happen naturally, I would love to welcome it with open arms.
Re: Can your diet help plan a twin pregnancy?
Why would fertility treatments to have twins be riskier than a diet to help conceive twins? The end result of a twin pregnancy would be the same. We have many happy twin stories here, but we also have some that did not turn out the way anyone would want. Twin pregnancies are hard on most women and aren't as safe for the babies. I love having twins and wouldn't trade that at all, but want to make sure you realize that a twin pregnancy is nothing like a single pregnancy. Thankfully I was blessed with luck and a great dr who was able to help when I started having issues.
So as far as diet, there are studies that show diets high in certain foods tend to "cause" twins more often. Usually that's when a whole society is eating something ad it's main food source. Adding those foods could possibly help a woman ovulate 2 eggs that might result in fraternal twins. Personally, I think most people would have to do a huge diet overhaul and even then it probably wouldn't have a high enough effect to make a big difference. I personally think the diet weeds to be a lifestyle for a while so the body is used to it.
Re: Can your diet help plan a twin pregnancy?
Yep, ditto the above. There have been links between food and twin pregnancies, but it usually isn't isolated to individuals who changed their diet and achieved a twin pregnancy. I don't think there is harm in trying to eat more of those foods you mentioned, but I'm not sure you are significantly helping your odds.
Twins are a huge blessing, but be careful what you wish for ;) My singleton pregnancy was a breeze, but with my twins I was on partial bedrest for 8 weeks and complete bedrest for 8 more weeks. The twins were born at 33 weeks, and spent 4 weeks in the NICU. This had nothing to do with the fact that I used fertility treatments, nor did my age play a factor (I'm only 31). It is great that you want to focus on the positive side of things, just please be aware that no matter how old/mature you are or how much you prepare, there is nothing in the world that can prepare you to watch your babies struggle to breathe because they were born early.
Good luck...I hope you achieve your dream of Motherhood!
Re: Can your diet help plan a twin pregnancy?
I ate sweet potatoes like a fiend for about 3 months before I conceived my twins. It wasn't on purpose, I just love them lol. I ate them practically every day.I dont know if that's why I had twins, butiI am the first in my FAM.
|All times are GMT -7. The time now is 06:02 AM.
Powered by vBulletin® Version 3.8.9
Copyright ©2000 - 2018, vBulletin Solutions, Inc.
Search Engine Optimization by vBSEO 3.6.0
Copyright © 2003-2012 JustMommies.com, All Rights Reserved.


text:
VAS infrastructure products company TeleDNA Communications Pvt. Ltd. will be powering the next generation social networking platform for NTC, Nepal.
Mr. Udit Shanker, CEO, TeleDNA Communications Pvt. Ltd said, "TeleDNA's UCS (Unified Communication System) is not another run-of-the-mill Social networking platform. It is a platform, which provides services such as, Entertainment and Infotainment to end mobile subscribers. The platform provides services for both end users and enterprise business users. TeleDNA has always been known to provide next generation technology today, and this platform proves this."
Ubiquitous Services Offered to Mobile Users:
- It enables mobile users to share video/picture/audio/text/chat with their friends, family and colleagues, who are part of UCS community or Facebook, Google+ or any other social network.
- It allows users to sync up their contact list and manage all their contacts on a single platform as unified Address Book.
- Ease of service activation: Single Platform to opt-in the services offered by NTC. Users can update their profiles, likes, interest with this information on hand. The platform does target based campaigns and relevant advertisement information push to those subscribers.
- Access Channels: Mobile Client Application for various handsets make models and OS through which mobile user is connected to the platform from anywhere. Mobile users can also access the UCS platform through SMS/USSD/WAP/Web Channels.
Ubiquitous Services Offered to Enterprise Users/Advertisement Users:
- Enterprise users are given an account on UCS platform and push the service related information to targeted end mobile users over SMS and MMS channels.


text:
Kukla's Korner Hockey
Only Winners & Losers
by Paul on 10/05/05 at 03:49 PM ET
Comments (0)
Tonight, for the first time in the 88-year history of the NHL, there can only be winners and losers as the regular season begins. No ties, just winners in regulation, winners in overtime and winners via the shootout. Which means only losers in all three categories, as well. With all 30 clubs in action tonight, that means by the end of the evening there will be 15 losers, and therefore 15 teams in a state of serious disagreement with the NHL's new standards of rule enforcement. That's how hockey works. The losers always complain bitterly about the refereeing and the rules, about how the game was decided by those in stripes, not those with sticks.
Filed in: | KK Hockey | Permalink
Be the first to comment.
Add a Comment
Please limit embedded image or media size to 575 pixels wide.
Add your own avatar by joining Kukla's Korner, or logging in and uploading one in your member control panel.
Captchas bug you? Join KK or log in and you won't have to bother.
Most Recent Blog Posts
Paul Coffey Named A Skills Development Coach For The Edmonton Oilers
USA Hockey's Jim Johannson Passed Away Suddenly This Morning
Vidoes- Bad Goal Of The Night Candidates
Brutal Loss For The Chicago Blackhawks
Video- Make-A-Wish Recipent In The Faceoff Circle Against Sidney Crosby
Morning Line- Bucky Gleason On The Buffalo Sabres
5-2- The St. Louis Blues Drop A Home Game To The Arizona Coyotes
Video- The Best From Saturday's Games In The NHL
About Kukla's Korner Hockey
Paul Kukla founded Kukla's Korner in 2005 and the site has since become the must-read site on the 'net for all the latest happenings around the NHL.
From breaking news to in-depth stories around the league, KK Hockey is updated with fresh stories all day long and will bring you the latest news as quickly as possible.
Email Paul anytime at firstname.lastname@example.com


text:
Font Awesome icon usage statistics
Font Awesome information of REALITY-LACEK.CZ in detail
- 0 types of Font Awesome iconic font are used and found 0 times in total.
- REALITY-LACEK.CZ used 0 Font Awesome classes per each class in average.
- Font Awesome usage statistics of REALITY-LACEK.CZ are based on first landing page and within top 1M websites only. Click the font icon to see all websites using it.
- REALITY-LACEK.CZ includes "http://reality-lacek.cz/wp-content/themes/shandora/framework/assets/css/frontend/font-awesome.css" to use Font Awesome and information from CSS is like below.
/*! * Font Awesome 4.0.3 by @davegandy - http://fontawesome.io - @fontawesome * License - http://fontawesome.io/license (Font: SIL OFL 1.1, CSS: MIT License) */


text:
We're "playing it forward" at this month's Ruggerbust, to support Miller Children's Hospital of Long Beach!
Announcing the new Board and Coach
Summer Touch Rugby
March Matches
March Ruggerbust
2016 Welcome Week is Here!
Los Angeles Rebellion Welcome Week is here! If you're interested in joining the team, have a fondness of bone-crunching sports and brotherhood, or just curious about the game of rugby, this is your chance to learn more about the sport and the Rebellion. All are invited - we welcome everyone regardless of sexual identity, age, ethnicity/race, religious affiliation, fitness level, body type or experience!
September Ruggerbust
It's Ruggerbust Time! Join us on Sunday September 4 @ the Eagle LA for hot rugby boys, cold beer and tasty food! $5 suggested donation (proceeds benefit the Rebellion's mission to promote equality and inclusivity through the sport of rugby.) Special thanks to our sponsors: Eagle LA, Coors Light and Continental Gourmet Sausage for their support of this month's Ruggerbust.


text:
Instantly revitalise your look with COLAB™'s ready-to-wear Extreme Volume dry shampoo formulation. The runway ready formula absorbs oil & refreshes roots with a residue-free, lightweight finish and leaves a gorgeous veil of fashion fragrance. Perfect for hair that wants more texture and body.
Available at London Drugs, Jean Coutu, Lawtons Drugs, select Rexall, Pharmasave, Guardian IDA, Brunet, Familiprix, Pharma Choice, Pharma Plus, Select Uniprix
For more info, please visit: http://www.farleyco.ca/COLAB/Products.html
A Favourite
I seriously love this dry shampoo! It rivals batiste for making my hair look freshly washed for sure! It does have a pretty hefty white cast, so it needs to be worked in, by after you've done that it honestly looks like freshly cleaned hair, it's amazing! Most of the time I'll put my dry shampoo in the night before so it has overnight to work into my hair. I have never tried a dry shampoo that gives me as much volume as this one, this is honestly worth it for the volume alone, on top of the fact that it's a great dry shampoo! And, it smells amazing too! It has a unique deeper scent that I really love!
OK, this stuff is awesome, don't get me wrong! But I don't know why I picked it up.. I have black hair!
For voulume and for making my hair less greasy, it works very well.
But on raven black hair, it looks like I rolled in flour!
I wish they would come out with a version for black hair, then I would be all over it! Until then, I won't be buying again and I'll be giving this one to a blonde friend..
I like this dry shampoo. We must say it really does what it is supposed to do, it gives volume! Lots of volume. For that reason a like it a lot. But it is definitely not the best. A bit too "crunchy" on the hair.
I received this product in my swag bag from Dufferin Mall Crawl. After reading the ingredients (Butane, propane, isopropane, alcohol..) I was reluctant to try it on my hair, and rightly so! I tried it on my dad in hopes it might be something he could use as he finds it hard to wash his hair as often as he used to due to breathing problems. I held the bottle well back and sprayed lightly.. And nearly died laughing at the sight!! His dark brown hair was greyish-white and beyond dry!! I combed it trough hoping it would spread evenly and blend in, that didn't happen! What happened had both my dad and I in tears from laughing so hard! I was able to comb his hair straight up into a mohawk!! Better yet, he shook his head around and his hair didn't move!!!
I love dry shampoo, and I enjoy trying new brands and finding ones that work for me. This one was pretty good, gave my hair volume and refreshed it. I also liked the sample size, so it is easy to carry in purse should it need be. Very easy to use, just apply it and massage your hair, I don't usually brush it out, but some people do it and it works for them.
Received this as part of the ShopCrawl event at Dufferin Mall. I will recommend this others and buy it again. Thanks ChickAdvisor!
I tried my friends dry shampoo as it didnt work for her hair. I have tried two others prio this one, so i dont have too much of an experience but I have some :)
I like the travel size, as that's so convenient, because I use it only in several occasions (when on a road, to freshen up, woke up too late for shower :) )
It seems to be doing its main job- freshening the look, i wouldn't say that it gave my hair volume,but my hair is pretty fine and volume lacking and is even a challenge for volumizing products, so I wasnt that upset :)
I didn't mind the scent and overall liked the product and would probably consider purchasing it.
I was my hair every 2-3 days, so this is a great alternative in between washes.
It is very powerful for a tiny little bottle. It goes on with force and the smell is beautiful, honestly if it were a perfume I would buy it
This dry shampoo gets rid of greasiness at the roots and it gave me a surprising amount of volume
I sprayed it on my roots and then put my hair in a messy bun, and it looked awesome
I'm sure it comes in a bigger bottle, which i will definitely be buying in the near future
Well done!
I'm really sorry to give this a poor review…it seemed to work okay but I really couldn't handle the smell. It was just a giant chemical cloud around my head and if I wasn't in such a rush to get to work I would have washed it all out. I've also used another brand and liked the effectiveness a lot more than this one.
I'm a huge dry shampoo user and have tried many in the past and have many different ones currently for different situations. This particular one is out of this world. I have never heard of it before the swagbag so I'm really thankful. It looks really posh and expensive but I looked it up and it's about average for the high-end stuff. It is ridiculously long lasting. Even my favourite one doesn't last this long. It acts as a hairspray kind of bc it just leaves you with so much volume and crunch effect. It is quite amazing.
This is a fantastic volumising dry shampoo. It adds volume and texture to my hair but doesn't add as much of a 'film' to my scalp as other dry shampoos do. I've tried the London and Rio scents and I like both of them.
These reviews are the subjective opinions of ChickAdvisor members and not of ChickAdvisor Inc.


text:
Last year, independent horror was, for the most part, defined by the less-is-more approach of blending psychological horror with supernatural horror. After all, while something popping out of a dark doorway will always be startling, the idea of something beyond our comprehension lurking behind that door is all the more scary. Of course, this approach was used in THE BABADOOK, UNDER THE SKIN, THE TAKING OF DEBORAH LOGAN and more, allowing filmmakers to play with the fantasy and storybook elements behind a horror tale and infuse it into real-world consequences. But where Ivan Kavanaugh's THE CANAL particularly succeeds is in how visceral the psychological horror can be, offering something much more terrifying and shocking than a sense of nightmarish foreboding.Read more »
Fearful Features,Movies/TV,News Ken W. Hanley
First look: Full cover and contents for FANGORIA #342, with Barbara Steele!Fango Local,Movies/TV,News Fangoria Staff
FANGORIA #342 will be coming to stores and arriving in mailboxes in the next month, and we've got the first peek at the cover and full contents of an issue celebrating one of the true queens of horror.Read more »
New Comments, Info: Lilli Carati's Swan Song, "VIOLENT SHIT: THE MOVIE"Movies/TV,News Roberto E. D'Onofrio
The sudden death of Italian actress Lilli Carati, on October, 20th 2014 left all her fans astonished, now orphaned of her talent. One of the most representative icons of Italian '70s and '80s sex-comedies, Carati also appeared in films of different genres such as SQUADRA ANTIFURTO, alongside Tomas Milian, and LA FINE DEL MONDO NEL NOSTRO SOLITO LETTO IN UNA NOTTE PIENA DI PIOGGIA, directed by Lina Wertmüller.Read more »
Netflix acquires Patrick Brice's Blumhouse stalker flick "CREEP"Movies/TV,News Ken W. Hanley
One of the more anticipated titles to hit the genre festival circuit in 2014, Patrick Brice's CREEP has had a strange behind-the-scenes ride on its journey to audiences. Initially acquired by Radius-TWC and later announced to be one of Blumhouse's BH Tilt titles, CREEP has been laying in wait for quite some time as sequel/trilogy talk and platform discussions continued on. And now, fright fans have their first solid news about the film's release, as Radius-TWC and Netflix have struck a deal to debut the film via the streaming platform worldwide on Tuesday, July 14th.Read more »
Lin Shaye Presented Wizard World Comic Con's "Godmother of Horror" AwardMovies/TV,News Ken W. Hanley
If you're one of the FANGO faithful out there, we likely don't need to tell you how much Lin Shaye kicks ass. She just does, in the warmest, nicest way possible. She's the comforting face that has graced a career's worth of horror titles, including A NIGHTMARE ON ELM STREET, BIG ASS SPIDER!, SNAKES ON A PLANE, CRITTERS, THE HIDDEN, NEW NIGHTMARE, CRITTERS 2, AMITYVILLE: A NEW GENERATION, 2001 MANIACS, THE NATURE OF THE BEAST, THE HILLSIDE STRANGLER, HOOD OF HORROR, CHILLERAMA, THE SIGNAL, OUIJA and, of course, the INSIDIOUS franchise. And now, with both INSIDIOUS: CHAPTER 3 and TALES FROM HALLOWEEN nearing their imminent premieres, Shaye added one more credit to her resume as she was presented Wizard World Comic Con's "Godmother of Horror" Award.Read more »
New Trailer: Guillermo del Toro's "CRIMSON PEAK"Movies/TV,News Ken W. Hanley
To be honest, this writer was very underwhelmed by the initial trailer for CRIMSON PEAK; the Nick Cave cover, unfinished CG and melodramatic flair made for a less-than-chilling first impression on this writer. However, any doubts I had with del Toro's massive and macabre ghost story has been dissipated by the latest trailer, which certainly seems to match its ambition with bloody creepiness. And the incredible scope and design of the production has finally crossed over into immersive territory, allowing del Toro's Gothic tale to hold the promise of an even more entrancing cinematic experience.Read more »
"HELLRAISER"/"HELLBOUND" Doc "LEVIATHAN" Now Available for DVD Pre-Order!Movies/TV,News Fangoria Staff
With the recent wave of documentaries in the horror world, some of the darkest corners of the industry have been unearthed, especially in regards to the genre's most beloved properties. But there's few shock docs that have caught FANGORIA's eye more than LEVIATHAN: THE STORY OF HELLRAISER AND HELLRAISER II: HELLBOUND, a comprehensive look at the first two entries of horror's most depraved franchise. And now, fans of the doc and of HELLRAISER history will be able to ensure that their pleasure comes in the form of a limited edition LEVIATHAN 3-Disc DVD set, which you can now pre-order at their official site.Read more »
"EXTRATERRESTRIAL" (Blu-ray Review)Movies/TV,News,Reviews Ken W. Hanley
When it comes to the Tribeca-friendly filmmaking duo known as The Vicious Brothers, I have to admit that I'll always keep a curious eye on their productions. Wherein their projects to date have a fair share of flaws, the GRAVE ENCOUNTERS films both contained an impressive amount of fun and frights to counteract said issues. So when I had learned that The Vicious Brothers would be returning properly with EXTRATERRESTRIAL, which would take them out of their found footage comfort zone with a much more ambitious story altogether, I was excited to see what they could do, despite hearing negative reviews from my colleagues. And with Scream Factory's release of the IFC Midnight flick, I finally found a good opportunity to catch the film and see for myself what EXTRATERRESTRIAL was all about.Read more »
"SALEM: Season 2, Episode 6" (TV Review)Movies/TV,News,Reviews Ken W. Hanley
For this writer, there's no denying it anymore: SALEM is by far the most satisfying horror show on television. Episode by episode, the insane writing, incredible SFX and generally perfect performances combines the individual satisfying aspects that made AMERICAN HORROR STORY, THE WALKING DEAD and BATES MOTEL so successful on their own accord. Yet SALEM has one thing those shows lack, and it's consistency, infusing their particular brand of horror and shock value storytelling with the organic character development and satisfying reveals of a masterful drama. And even better is SALEM's refusal to draw a line on the show either: incest, torture and stomach-turning gore have become staples of the second season, served with an unabashed and maniacal grin.Read more »
Take the plunge into award-winning "MIDNIGHT SWIM"; release details setMovies/TV,News Michael Gingold
One of Fango's favorite films from the fest circuit over the past year is the supernaturally tinged psychodrama THE MIDNIGHT SWIM, and more viewers will be able to experience it this summer.Read more »
Terror Tube: "DAMIEN", "FEAR THE WALKING DEAD", "THE X-FILES"Movies/TV,News Ken W. Hanley
Man, how the times have changed. Ten years ago, there was nary a horror show on television: DEXTER and TRUE BLOOD hadn't hit premium cable, X-FILES was long gone and MASTERS OF HORROR was gearing up to be the most high profile horror show on television. Now, THE WALKING DEAD and AMERICAN HORROR STORY break rating records with each passing season, HANNIBAL and SALEM are reintroducing incredible practical SFX to TV and properties such as THE EVIL DEAD, PREACHER and more are making their way to the small screen. And now, FANGORIA has a trio of updates on some of the most anticipated upcoming scare fare on television, so get your calenders ready and sharpen your pencils, faithful readers…Read more »
Exclusive Clip: Craig Goodwill's "PATCH TOWN", starring Julian Richings!Movies/TV,News Ken W. Hanley
Craig Goodwill's debut fright feature, PATCH TOWN, has certainly had one hell of a journey to fruition. After debuting in the shorts program at the 2011 Toronto International Film Festival, the concept was adapted in the following years into a full-fledged feature film, and is now almost upon us here in North America. And with the film now officially up for pre-order on iTunes Canada, FANGORIA has an exclusive clip from PATCH TOWN to unleash upon the world!Read more »


text:
In one week, Steven Torres will leave his $120,000 job as corporation counsel after 2½ years working for Mayor Will Flanagan, whom he supervised during a prior 10-year career as Taunton's city solicitor.
Assistant corporation counsel Elizabeth Sousa will be promoted July 30 to fill Torres' job. Sousa supervised Flanagan from 2005-07 when they both worked in Taunton District Court.
In one week, Steven Torres will leave his $120,000 job as corporation counsel after 2½ years working for Mayor Will Flanagan, whom he supervised during a prior 10-year career as Taunton's city solicitor.
Assistant corporation counsel Elizabeth Sousa will be promoted July 30 to fill Torres' job. Sousa supervised Flanagan from 2005-07 when they both worked in Taunton District Court.
Within a month, Sousa will review Law Department duties and present a plan for staffing and organizing it.
During the past week or so, Flanagan said, "Liz and Steve have been planning for the transition."
"This was a surprise. I didn't see it coming," said Sousa, 35, a lifelong city resident and former Bristol County assistant district attorney. "I appreciate the opportunity and look forward to it."
"This is a wholesale change in my professional career," Torres said in an interview Thursday. Torres has been a Taunton resident for 22 years.
He called Fall River "a great place, I feel, to wind down my government career," which included military service with the Air Force, where he achieved the rank of captain.
By fall, he plans to set up a private practice on the Taunton Green and use his expertise in several cutting-edge fields with clients he's established.
Despite his professed interest in running for elected offices in Taunton — including mayor, City Council and state legislator — Torres, 46, used a metaphor from a favorite hobby, sailing, to describe the change.
"You can't discover new oceans until you have the courage to lose sight of the shore," he said.
Torres has played a key legal role advising the city on how to develop a resort casino both before and after gaming was legalized, and he has watched Taunton gain the upper hand recently with a nearly completed casino compact with the Mashpee Wampanoag Tribe.
He acknowledged the bind.
"Did it cause me to leave? No," he said. But, he said, "I am very relieved I won't have to be the quarterback in that grid match.
"I never intended to make government service a career. I planned for some time the transition back to a private career and private life, and I pulled the trigger."
Torres said, "As early as January this year, I had made my decision that, at the end of my contract year (Dec. 31) or at the end of the fiscal year (June 30), I'd be leaving."
Torres, who's been divorced for about five years, also signified that his children — T.J., 20, in college in San Diego; Andrew, 14, who recently completed eighth grade at the Antioch School in Fall River; and Lauren, 11 — are very important to him, and that he's excited about having more time with them.
"My children are my life. I love being with my kids," Torres said, relishing summertime with them after a job that often keeps him away.
Despite high-profile confrontations with some city officials, Torres said he "really enjoyed" coming to work and the people he worked with. He said seeing government workers recoup their 8 percent pay cuts and the ranks of public service increase were some of the high notes, along with the city winning the strip club suit that Sousa litigated.
The low point was being rebuffed in trying to establish a casino.
"I think that was well-intended," Torres said, "and a good opportunity for Fall River." He said Flanagan lived up to his promise "not to lose both" the casino and the biopark.
Flanagan was the fourth mayor Torres worked under after Ted Strojny, Robert Nunes and Charles Crowley in Taunton.
Of his replacement, he said Flanagan made the right choice.
"I think Liz will do a great job. She's a great trial attorney. She works very hard. She's very organized and she has good judgment."
Sousa's salary will be $115,000, and a contract through Dec. 31, 2013, is being finalized.
A practicing lawyer for 10 years after graduating from the University of Massachusetts Law School, Sousa held supervisory jobs as an assistant district attorney in the Taunton and Fall River district courts. She was promoted to the Superior Court abuse unit for 1½ years before Flanagan hired her.
Describing her prior criminal prosecution background compared with municipal law, Sousa said, "When you look at it, it's really not that much different. You research the laws and apply it to the cases."
"I took a lot of what I learned at the DA's office and what I learned I applied to my position here. And I intend to do that as corporation counsel," Sousa said.
Email Michael Holtzman at firstname.lastname@example.com.


text:
School Meals are provided by Principals Catering Services and are freshly prepared and cooked in Iwade School's kitchen
ALL children in Reception, Year One and Year Two receive a FREE school meal every day.
Please click on the image below to view the Autumn/Winter 2017-2018 Menu
Menu-Autumn-Winter-17-18.pdf (228 downloads)
Timu Academy Trust complies with the latest Government Food Standards for school meals.
The cost of a meal for pupils in all other year groups is £2.30, which must be paid in advance.
Payments should be made via The School Gateway
The minimum payment is £11.50, which will cover 5 meals to be taken at any time during your child's time at Bobbing School.
The minimum payment of £11.50 also applies to cash payments with effect from September 2015.
If you think that your child may be entitled to free school meals because you are in receipt of certain benefits, please make an application here.
Pre-booking of meals is not required, other than special occasion meals such as the Christmas Dinner.
If your child does not want the meal, they should bring in a packed lunch (see guidelines below) and ensure that they tell their teacher at morning registration.


text:
|Home | About | Journals | Submit | Contact Us | Français
Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown.
We used information on traditional risk factors and 10 common genetic variants associated with breast cancer in 5590 case subjects and 5998 control subjects, 50 to 79 years of age, from four U.S. cohort studies and one case–control study from Poland to fit models of the absolute risk of breast cancer. With the use of receiveroperating- characteristic curve analysis, we calculated the area under the curve (AUC) as a measure of discrimination. By definition, random classification of case and control subjects provides an AUC of 50%; perfect classification provides an AUC of 100%. We calculated the fraction of case subjects in quintiles of estimated absolute risk after the addition of genetic variants to the traditional risk model.
The AUC for a risk model with age, study and entry year, and four traditional risk factors was 58.0%; with the addition of 10 genetic variants, the AUC was 61.8%. About half the case subjects (47.2%) were in the same quintile of risk as in a model without genetic variants; 32.5% were in a higher quintile, and 20.4% were in a lower quintile.
The inclusion of newly discovered genetic factors modestly improved the performance of risk models for breast cancer. The level of predicted breast-cancer risk among most women changed little after the addition of currently available genetic information.
Personalized medicine, the assignment of preventive measures or treatment interventions on the basis of individual characteristics, can result in better outcomes than the use of the same strategy for everyone. Recent changes in the U.S. Preventive Services Task Force guidelines1 for mammographic screening raise the question of whether recommendations about age at the onset of screening and the frequency of screening can be calibrated to an individual woman's risk of breast cancer. Clinicians already use guidelines in making decisions about assessments to identify carriers of rare BRCA1 and BRCA2 mutations, which confer very high risks of breast cancer and ovarian cancer.2 Single-nucleotide polymorphisms (SNPs) that have been shown to be associated with breast cancer in genomewide association studies3 are common but confer only small increases in risk. Whether these variants collectively enhance the identification of women at increased or reduced risk is unknown.
The Breast Cancer Risk Assessment Tool,4,5 commonly referred to as the Gail model, summarizes information about a woman's reproductive history, breast cancer in close relatives, and previous breast biopsies to estimate the probability of the development of breast cancer in subsequent years; the estimated breast-cancer risk based on the Gail model has been used for counseling, informing decisions about the use of tamoxifen,6 and determining sample size in randomized prevention trials.7 In this study, we empirically evaluated the contribution of a set of 10 newly established common genetic variants as an alternative to and as a supplement to the components of the Gail model in 5590 case subjects and 5998 control subjects, 50 to 79 years of age, included in the National Cancer Institute's Cancer Genetic Markers of Susceptibility multistage genomewide association study of breast cancer.8
Investigators from the Women's Health Initiative Observational Study,9 the American Cancer Society Cancer Prevention Study II Nutrition Cohort,10 the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (ClinicalTrials.gov number, NCT00002540),11 and the Nurses' Health Study12 collected information and specimens at baseline and clinical observations of the subjects for up to 15 years of follow-up. We also used data from the Polish Breast Cancer Study,13 a population-based case–control study in Warsaw and Lodz, Poland.
All case subjects were women who had received a diagnosis of invasive breast cancer. Additional descriptions of the studies, including methods for case ascertainment and selection of control subjects, are included in Appendixes 1, 2, and 3 in the Supplementary Appendix, available with the full text of this article at NEJM.org.
We included components of the Gail model that were collected prospectively in the four cohort studies and retrospectively in the case–control study. These components were the number of first-degree relatives with a diagnosis of breast cancer, age at menarche, age at first live birth, and number of previous breast biopsies. Mammographic density and diagnosis of atypical hyperplasia, which have improved the performance of the Gail model in other studies,4,14 were not available for most studies and were not used in this analysis.
We analyzed genotypes in case subjects and control subjects for 10 SNPs with established associations with breast cancer that achieved genomewide significance in three published genomewide association studies.8,15 Some of the data used in our analysis were reported in earlier articles on the discovery of susceptibility alleles.8,16-18 Genotypes used in this analysis were described in a recent article about the Cancer Genetic Markers of Susceptibility study.8 Complete genotype data from a total of 5590 case subjects and 5998 control subjects were available for analysis after the exclusions described in Table 1 in the Supplementary Appendix.
We fit a family of five logistic-regression models, including combinations of demographic factors (age, entry year, and cohort), the components of the Gail model, and genotypes for the 10 SNPs. The demographic model included demographic factors only; adjustment for age is described in Appendix 4 in the Supplementary Appendix. The nongenetic model added components of the Gail model to incorporate standard risk factors and reflect current clinical practice. Two models included demographic and genetic factors only: the genetic variant-count model included the number of risk-conferring variant alleles (one allele for heterozygotes and two alleles for homozygotes) in categories of fewer than 6, 7 to 8, 9 to 10, 11 to 12, and 13 or more; the genetic individual-variant model included separate effects of the 10 individual SNPs. The inclusive model combined demographic factors, components of the Gail model, and the 10 SNPs into a single model. Tables 1, ,2,2, and and33 show the distribution of case subjects and control subjects according to cohort, age, and factors in the models. Except for age and year of study entry, all variables were fit as categorical terms.
We investigated whether interactions between components of the Gail model and genetic variants would improve the performance of the relevant models. To avoid complex issues involving model selection that are beyond the scope of this article, we evaluated nonmultiplicative effects using the Tukey 1-degree-of-freedom test applied to the interaction term between the risk scores based on the Gail model and those based on the genetic variants19,20 and a 16-degree-of-freedom test based on quintiles of the two scores. Further details are included in Appendix 5 in the Supplementary Appendix.
We combined the risks from the logistic models, crude rates of breast cancer for each underlying cohort, and registry data to estimate the absolute risk of breast cancer per year, as described in Appendix 6 in the Supplementary Appendix. We used rates of breast cancer from U.S.21 and Polish22 registries, as appropriate.
Using receiver-operating-characteristic (ROC) curve analysis, we calculated the area under the curve (AUC), also known as a concordance (C) statistic, to assess discrimination. Each point on the ROC curve shows the effect of a rule for turning a risk estimate into a prediction of the development of breast cancer in a woman. The y axis of the ROC curve is the true positive rate or sensitivity (i.e., the proportion of women with breast cancer who were correctly predicted to have the disease). The x axis shows the false positive rate (the complement of specificity) (i.e., the proportion of women without breast cancer who were incorrectly predicted to have breast cancer). The area under the ROC curve, the AUC, measures how well the model discriminates between case subjects and control subjects. An ROC curve that corresponds to a random classification of case subjects and control subjects is a straight line with an AUC of 50%. An ROC curve that corresponds to perfect classification has an AUC of 100%. Figure 1 shows a modified ROC graph, in which the y axis is the true positive rate and the x axis is the false positive rate in the population instead of the rate among control subjects only.15
To compare the performance of the models, we calculated the cross-classification of the assignment of case subjects into predicted risk bands of women with similar risk. The cutoff points were determined according to quintiles of estimated risk among case subjects and control subjects, weighted according to the inverse sampling fraction so as to apply the model to the underlying cohort (Appendix 7 in the Supplementary Appendix). We also used integrated discrimination improvement23 as a measure to compare models without setting cutoff points. This measure compares two models for the change in the difference in the average estimated annual risk of breast cancer between case subjects and control subjects20; thus, the integrated discrimination improvement will be large for a model that assigns a greater estimated risk to case subjects and a lesser estimated risk to control subjects. Details about the assessment of precision, testing of models, and extent of overfitting are included in Appendixes 8 and 9 in the Supplementary Appendix.
The associations between each predictor and breast-cancer risk were consistent with published data, and they were similar in the different models (Table 2 in the Supplementary Appendix). Notably, the effect of a family history of breast cancer did not materially change after adjustment for SNPs. The risk of breast cancer among women who carried 13 or more of a maximum of 20 riskconferring variant alleles (which occur in about 4% of the population) was nearly three times the risk among women who carry 6 or fewer variants (12%).
Table 3 in the Supplementary Appendix shows a comparison of how the models discriminated between women with breast cancer and those without the disease. The AUC for the demographic model was 53.4%. The addition of the SNP from the fibroblast growth factor receptor 2 gene (FGFR2) increased the AUC to 55.7%. The addition of four more SNPs (from Tox high-mobility group box family member 3 [TOX3], mitogenactivated protein kinase kinase kinase 1 [MAP3K1], chromosome 1p, and a RAD51-like 1 [RAD51L1]) increased the AUC further, to 57.9%. The AUC for the 7 SNPs described by Pharoah et al.15 was 58.6%, and the addition of the 3 others to incorporate all 10 SNPs listed in Table 3 in the Supplementary Appendix increased the AUC only to 59.7%. The discrimination in the simpler genetic variant-count model was somewhat less (58.9%).
Among the individual nongenetic factors, a history of breast biopsy yielded the greatest AUC (56.2%). The nongenetic model, with the use of all four components of the Gail model, showed an AUC of 58.0%. The inclusive model, with components of the Gail model and 10 SNPs, yielded an AUC of 61.8%, an increase of about 3.8 percentage points over the nongenetic model and 2.1 percentage points over the genetic individualvariant model. In short, the AUC for the genetic models was only slightly higher than the AUC for the nongenetic model, and the addition of the components from the Gail model increased the AUC by 2 more percentage points; thus, discrimination by means of the inclusive model is better than discrimination by means of either the genetic or nongenetic models. In parallel, integrated discrimination improvement, or the difference in the estimated annual risk of breast cancer between case subjects and control subjects, ranged from 0.015 to 0.022% in the inclusive model (Table 3 in the Supplementary Appendix). Our empirical analysis indicated a modest increment in discrimination by means of the inclusive model in relative and absolute terms, despite very low P values.
We also empirically examined the performance of high and low absolute risk (i.e., the performance of the models for women who might be singled out for more aggressive or less aggressive intervention than women at average risk). The genetic models yielded better discrimination than the nongenetic models among women at the lowest estimated risk (Fig. 1B), but not among women at the highest estimated risk (Fig. 1C). For women with a risk estimated from the inclusive model that was above the median in control subjects, the AUC was 58.8%, but it was only 56.6% for women with an estimated risk that was above the 80th percentile.
Table 4 in the Supplementary Appendix shows how the addition of genetic data affected classification of the case subjects with breast cancer. The percentages of all case subjects according to quintiles of absolute risk are shown for the inclusive and nongenetic models. The estimated annual risk was above 0.575% for substantially more case subjects with the inclusive model than with the nongenetic model (27.7% vs. 18.9%). Slightly fewer than half the case subjects (47.2%) were in the same category in both models. A total of 32.5% of the case subjects were in a higher-risk category with the inclusive model than with the nongenetic model, and 20.4% were in a lower category. The corresponding percentages for the control subjects were 26% and 28%. We found no evidence that a complex model involving interactions among Gail model components and SNPs performed materially better than the models described here (P>0.10).
In our study involving 5590 case subjects with breast cancer and 5998 control subjects, the addition of information on 10 genetic variants to a standard clinical breast-cancer risk model predicted the risk of breast cancer only slightly better than the clinical model alone. In the inclusive model, the ROC curve was above 60% of the possible AUC. That is, about 60% of the time, a randomly selected patient with breast cancer had a higher estimated risk than the risk for a randomly selected woman in whom breast cancer did not develop during the follow-up period. By contrast, a single dichotomous risk factor detected in 60% of case subjects and 40% of control subjects (odds ratio, 2.25; AUC, 60%) would discriminate about as well as our model by the AUC criterion. We saw similarly modest improvement using measures based on the change in estimated risk. Although our data suggest that the SNP-only model predicted risk slightly better than the Gail model, the nongenetic clinical variables are available at essentially no cost, whereas the costs of obtaining genetic information are likely to be substantial.
We have evaluated risk-prediction models as we would any other clinical test. Our results are presented in terms of absolute risks, which are easily translated into positive and negative predictive values in considering who will benefit from a clinical test, including a risk model.24-26 Our findings were based on a large number of case subjects and control subjects, drawn from four prospective cohorts and one population-based case–control study. Our inclusive model incorporated information on components of the Gail model and genotypes of newly established SNPs; this information is not often included together in the same study. Our analysis also had technical advantages over other risk-modeling efforts: we fitted the effects of age and cohort so as not to give the models credit for fit based on demographic factors; we were able to assess the effect of adding SNPs on estimated risk and on changes in risk category for case subjects and for a hypothetical population.
There were some unavoidable weaknesses of this study and its data sources, particularly in evaluating risk for clinical use. For example, we pooled data from four U.S. cohort studies and a case–control study from Poland; these studies had different designs and enrollment characteristics. We included only women of European ancestry in the empirical analysis, and we did not consider subtypes of breast cancer. As a group, the study participants are not representative of any specific population. Screening practice may vary within and among studies. Because of self-selection for participation in the studies, we expect that the average risks in the U.S. studies will be different from each other and from the U.S. average. Similarly, in a clinical context, we cannot expect the risk for an individual woman to be the same as the average risk for a population. Our estimates of the performance of the risk models may be slightly higher than can be expected in typical clinical settings because we report results with minor overfitting. Given the complexity of the model with 4 Gail model components and 10 SNPs, we chose to fit each factor without constraints but did not attempt to evaluate hundreds of interactions among the factors or with age and cohort. Our simple interaction models gave no suggestion of improved performance from interactions between genetic and Gail model components; more sophisticated modeling may improve the performance of these factors in predicting breast-cancer risk. Finally, comparisons of models are slightly unfavorable to the Gail model because we could not include the history of atypical hyperplasia and information on mammographic density. Although they are not routinely incorporated into the Gail model, these factors may improve the performance of future versions of the model.14
Our analysis indicates that the genetic variants we studied provide modest improvements in discrimination and prediction models, whether measured as the AUC, as a discrimination index, or as a change in position in broad bands of risk, such as might be used in clinical settings. We see little evidence of benefit from including genetic variants at the extremes of high and low risk, categories in which further stratification might be most valuable. This empirical demonstration of the potential benefit of adding SNP data to breast-cancer risk models based on individual data is generally consistent with theoretical predictions15,27 that use published estimates of effect.
Because statistics such as the AUC and integrated discrimination improvement do not provide a readily intuitive sense of the clinical usefulness of these models, we focused much of our discussion on the degree of incremental improvement associated with adding the genetic variants. As in diabetes28 and cardiovascular disease,29 the addition of the common SNPs added little to the predictive value of the clinical models. On the basis of theoretical models, Gail30 has shown that increases in the AUC similar to those observed here are not sufficiently large to improve meaningfully the identification of women who might benefit from tamoxifen prophylaxis or assignment of screening mammography.
Although the Gail model and SNP-inclusive models may help to identify groups of women who have an increased risk of breast cancer for trials of interventions, none of the models in our set of data accurately predicted the development of breast cancer. Our results indicate that the recent identification of common genetic variants does not herald the arrival of personalized prevention of breast cancer in most women. Even with the addition of these common variants, breast-cancer risk models are not yet able to identify women at reduced or elevated risk in a clinically useful way.
Supported in part by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics of the National Cancer Institute and by grants from the National Institutes of Health (N01WH22110, P01 CA87969, P01 CA53996, R01 CA49449, U01CA098233, and U01CA098710).
We thank Prisca Fall-Keita and David Check for assistance in preparation of an earlier version of the manuscript and the late Dr. Eugenia Calle for her contributions in developing the American Cancer Society cohort.
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
John Derek Sangster
ALTHA - John Derek Sangster, 62, of Altha, passed away Tuesday, April 11, 2017 in Tallahassee. Born in Winter Garden, Nov. 10, 1954, he was the son of the late J. D. Sangster and Martha Alexander Baggett. He was a truck driver who enjoyed farming and he was an avid outdoorsman.
He was preceded in death by his parents; two brothers, Bobby and Jimmy Sangster; two nephews, Jamie Bigford and Kevin Temple; and a niece, Regina Bigford.
Survivors include his son, Bo Sangster of South Carolina; three sisters, Debbie Barfield and Janice Atwell and her husband, Thomas, all of Blountstown and Sherry Grover of Pennsylvania; an aunt, Betty Yager of Dade City; two uncles, Jerry Alexander of Sneads and George Alexander of Pensacola; and a host of nieces, nephews and other extended family.
Family will receive friends one hour prior to service time at the funeral home.
Services will be held Friday, April 14 at 3 p.m. at Adams Funeral Home. Interment will follow in Sunny Hill Cemetery near Altha.
Adams Funeral Home is in charge of the arrangements. You may offer the family condolences online at adamsfh.com.


text: From MWSE: The Sea Eagles first trial match is to be played against the South Sydney Rabbitohs in a traditional clash at Redfern Oval on Sunday 7th February. This will coincide with the 40-year anniversary of the historic 1970 Grand Final between the two sides. The Rabbitohs team will feature new recruits Sam Burgess and David Taylor. The All Stars match will start at 4:20pm featuring ex-players and celebrities with the main game kicking off at 6pm. All 2010 Gold Sea Eagles Members will receive a ticket to this match as part of their membership - your tickets were posted to you this week. A limited amount of tickets are now on sale to Sea Eagles Members only www.seaeagles.com.au/book, you must be a member to purchase a ticket and all orders will be checked.