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Our award winning restaurants are open seven days a week, making more than 40 varieties of burgers from scratch in each restaurant every day.
The nearest branches of Handmade Burger Co to Lichfield are based in Birmingham at Brindleyplace and The Bullring.
Friday, 29 January 2016
Thursday, 28 January 2016
Wednesday, 27 January 2016
NHS England - Developing Mental Health Services for Veterans in England
NHS England launched an online survey around mental health services for veterans - https://www.engage.england.nhs.uk/survey/veterans-mental-health-services
The deadline for responses is 5pm on 31 March 2016 and they are particularly keen to hear from the following groups:
· Veterans who have or have had a mental health condition
· People who know veterans who they believe have or have had a mental health condition
· Service charities / support groups
· Mental health professionals involved in veterans' mental health care
Posted by Lichfield HIVE at 10:18
Labels: Healthcare
Tuesday, 26 January 2016
Moving School Packs are availble from the HIVE
Moving School Packs are availble from the HIVE
Service Children's Education Advisory Service
The Children's Education Advisory Service (CEAS) provides expert and impartial advice about the education of service children.
CEAS provides information and advice as well as supporting parents at meetings with schools, local authorities, at tribunal etc. No question is too small or too large for us to deal with. If we don't know the answer ourselves we usually know someone who does.
Posted by Lichfield HIVE at 14:41
Labels: Education, Relocation
Thursday, 21 January 2016
CarillionAmey - Furniture and Removals - A Step by Step Guide
Posted by Lichfield HIVE at 14:26
Labels: Accommodation
Wednesday, 20 January 2016
Army Families Federation - F & C Information
|Click HERE for more information
Posted by Lichfield HIVE at 13:10
Labels: Foreign & Commonwealth
Monday, 18 January 2016
Monday, 11 January 2016
Childcare.co.uk is an award winning online social networking platform for parents, childcare providers and private tutors with over 1,000,000 members. Start your childcare search or childcare job search today.
By typing in what you are looking for in terms of childcare, such as a baby sitter, maternity nurse, private tutor or schools, together with your postcode, this website will do the work for you. It also helps you look for childcare jobs! A great resource to go to f
or when moving to a new area.
All free to register.
By typing in what you are looking for in terms of childcare, such as a baby sitter, maternity nurse, private tutor or schools, together with your postcode, this website will do the work for you. It also helps you look for childcare jobs! A great resource to go to f
or when moving to a new area.
All free to register.
Posted by Lichfield HIVE at 15:12
Labels: Education
Monday, 4 January 2016
RAF Benevolent Fund - Building Stronger Families Course
The RAF Benevolent Fund has now launched its new online 'Building Stronger Families' Course, which can be found at this link:http://rafbf.relate.org.uk/ The course, which is free to RAF personnel and their families, is entirely online so that individuals can complete either the whole course, or just those sections they feel might benefit them, in the privacy of their own home. Topics include:
- Being a Couple
- Communication
- Sexual Communications and Intimacy
- Changing Roles
- Resolving Conflict
- Step Parenting
- You, Me and the Military
The course has been designed by Relate, registration is quick and easy and individuals can choose to work through the content individually, or with a partner. Whilst individuals need to register with their Service number or their partner's Service number, registration is entirely confidential and individuals' details will not be shared with the RAF. The course is intended for RAF personnel and their families who want to make the best of their relationships, whether they are married or not.
Posted by Lichfield HIVE at 14:29
Labels: Welfare
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The legal services marketplace is changing. Increasing regulatory requirements and a more competitive environment means that running a law firm is becoming harder. Many small to medium-sized firms are unable to invest in technology to adapt and grow. With no clear succession strategy, partners often find themselves "locked in" without a means of realising value from their businesses.
Prolegal is a new breed of law firm. Our modern, technology-led business model enables our lawyers to focus their time and energy on finding solutions to their clients' legal problems. Prolegal acquires existing law firms and empowers the partners of those firms to grow and develop their client relationships from their existing premises under their current brand name. Free from the burden of running a law firm, partners are able to provide high quality services that are trusted and valued by both business and consumer clients across their local communities.
Prolegal is based in London and is a subsidiary of the Gordon Dadds group of companies, one of the UK's fastest growing professional services providers.
Contact us for a confidential discussion about becoming a Prolegal law firm.
Contact us | About us | Privacy Policy | Cookies | Website Terms & Conditions | Investors | Our regulatory information is below:

subset: commoncrawl


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A new project to educate children who often fall between the cracks in mainstream schools faces an uncertain future. Lower Hutt teachers Kelly Layton, Clare Curry, and Natasha Furness started Akoranga o Naenae this year.
Their one-day school uses a method that puts children in the driving seat of their own learning, boosts self-esteem, and gives them a sense of place in the world.
Members of the school community join Kathryn Ryan in the Nine to Noon studio to talk about the school.


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|Located it Bucks County, Pennsylvania
Thursday, April 20, 2017
Finding Spring
8 comments:
How pretty!!! We're finally really blooming here!ReplyDelete
Yay for you to be able to be outside. I thought I was in trouble this year, when after one day in the garden my eyes were so red, and full of gunky, but it seems to have cleared up and not come back.ReplyDelete
LOVE the flowers, ALL of them. just gorgeous. My favorite is the prince in hiding. so handsome sitting on his rock throneReplyDelete
I really love the colors and light in your second picture - magic! Also the frog. Love the frog.ReplyDelete
Your photos are gorgeous! Wish I could take ones like this. There is something so special about them. Favorites are the second one and the gorgeous frog! I come from MadSnapper and live in the Blue Ridge Mountains of Virginia.ReplyDelete
Happy Spring and glad you will be able to enjoy it this year. And of course we will be the benefactors of you health because we get to see these gorgeous photos. Love the hot pink flower and the frog!ReplyDelete
I'm glad you're taking your allergy shots.ReplyDelete
Glad you can take as many shots now as you want to in Spring! Great captures as always, Rebecca! Hope to see you back soon at All Seasons (remember the meme I'm doing?) The title this week is All Seasons May Dazzles. Have a lovely week:)ReplyDelete


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Latest Titles With Chris Evans
- Job Types
- Movies or TV
- Genres
- Keywords
- IMDb Rating
- Instant Watch Options
- In Theaters
- On TV
- Release Year
1. Jekyll (II)
The only living descendant of Dr. Jekyll and Mr. Hyde makes a deal with the dark side.
Director: Ruben Fleischer | Star: Chris Evans
2. Untitled Avengers Movie (2019)
Action, Sci-Fi | Filming
The culmination of the Marvel Cinematic Universe.
Directors: Anthony Russo, Joe Russo | Stars: Karen Gillan, Brie Larson, Scarlett Johansson, Chris Hemsworth
3. Avengers: Infinity War (2018)
Action, Adventure, Fantasy | Post-production
The Avengers and their allies must be willing to sacrifice all in an attempt to defeat the powerful Thanos before his blitz of devastation and ruin puts an end to the universe.
Directors: Anthony Russo, Joe Russo | Stars: Karen Gillan, Pom Klementieff, Tessa Thompson, Chris Pratt
4. The Red Sea Diving Resort (2018)
Drama, History, Thriller | Post-production
Director: Gideon Raff | Stars: Chris Evans, Haley Bennett, Alona Tal, Michiel Huisman
5. Spider-Man: Homecoming (2017)
PG-13 | 133 min | Action, Adventure, Sci-Fi
Peter Parker balances his life as an ordinary high school student in Queens with his superhero alter-ego Spider-Man, and finds himself on the trail of a new menace prowling the skies of New York City.
Director: Jon Watts | Stars: Tom Holland, Michael Keaton, Robert Downey Jr., Marisa Tomei
Votes: 268,650 | Gross: $334.20M
6. Gifted (2017)
PG-13 | 101 min | Drama
Frank, a single man raising his child prodigy niece Mary, is drawn into a custody battle with his mother.
Director: Marc Webb | Stars: Chris Evans, Mckenna Grace, Lindsay Duncan, Octavia Spencer
Votes: 56,965 | Gross: $24.80M
7. The 89th Annual Academy Awards (2017 TV Special)
TV-14 | 229 min
The 89th Annual Academy Awards ceremony celebrates the film industry's best and biggest in cinema for the year 2016 with host Jimmy Kimmel, including awards for best actors, directors, songs, original screenplays and motion picture.
Director: Glenn Weiss | Stars: Jimmy Kimmel, Justin Timberlake, Alicia Vikander, Mahershala Ali
Votes: 1,371
8. Chris Evans Pranks Comic Fans with Surprise Escape Room (2017 TV Short)
Director: Justin Lazernik | Star: Chris Evans
Ellen: The Ellen DeGeneres Show (2003– )
Chris Evans & Mckenna Grace/Drew Barrymore/Lewis Howes/Stephen 'tWitch' Boss
TV-G | Comedy, Talk-Show
Actors Chris Evans and Mckenna Grace (Gifted (2017)); actress Drew Barrymore makes a cameo appearance; podcast host Lewis Howes; guest DJ Stephen Boss.
Director: Liz Patrick | Stars: Ellen DeGeneres, Drew Barrymore, Stephen Boss, Chris Evans
Jimmy Kimmel Live! (2003– )
Chris Evans/Amanda Peet/Mastodon
TV-14 | Comedy, Music, Talk-Show
Actor Chris Evans (Gifted (2017)); actress Amanda Peet (Brockmire (2017)); Mastodon performs.
Directors: Maureen Bharoocha, Jonathan Kimmel | Stars: Jimmy Kimmel, Chris Evans, Amanda Peet, Mastodon
Late Night with Seth Meyers (2014– )
Chris Evans/Mandy Patinkin/Michelle Branch/Jonathan Mover
TV-14 | Comedy, Talk-Show
Actor Chris Evans (Gifted (2017)); actor Mandy Patinkin (Smurfs: The Lost Village (2017)); Michelle Branch performs; Jonathan Mover sits in with The 8G Band.
Stars: Seth Meyers, Chris Evans, Mandy Patinkin, Michelle Branch
Votes: 7
Extra (1994– )
Episode #23.185
Remembering Don Rickles; an interview with Omarosa Manigault.
Stars: Mario Lopez, Charissa Thompson, Tracey E. Edmonds, Renee Bargh
Entertainment Tonight (1981– )
Episode #36.170
Dancing with the Stars (2005) highlights; Jessica Chastain's new movie, The Zookeeper's Wife (2017); Chris Evans (Gifted (2017)); Abby Lee Miller quits Dance Moms (2011); Eminem's daughter; ... See full summary »
Stars: Nancy O'Dell, Kevin Frazier, Cameron Mathison, Nischelle Turner
Entertainment Tonight (1981– )
Episode #36.177
An interview with Carrie Underwood; June Shannon (Mama June) talks about her weight-loss journey.
Stars: Nancy O'Dell, Kevin Frazier, Nischelle Turner, Jennifer Peros
Dish Nation (2011– )
Episode #5.153
TV-PG | News
Pepsi's new commercial, featuring Kendall Jenner; dishing with Chris Evans and Octavia Spencer about their new movie, Gifted (2017); the latest on Nas, Beyoncé, Jay Z, Kirsten Dunst, Katy ... See full summary »
Stars: Chris Evans, Octavia Spencer
Good Morning America (1975– )
Episode dated 6 April 2017
TV-G | News, Talk-Show
Actor Chris Evans (Gifted (2017)); actor Zach Woods (Silicon Valley (2014)); Easter baskets; deals and steals with Tory Johnson.
Stars: Robin Roberts, George Stephanopoulos, Michael Strahan, Lara Spencer
Good Morning America (1975– )
Episode dated 7 April 2017
TV-G | News, Talk-Show
Julia Roberts, Demi Lovato and Joe Manganiello (Smurfs: The Lost Village (2017)); Chris Evans (Gifted (2017)); Marian Hill perform; author Matthew John Dowd (book, "A New Way").
Stars: Robin Roberts, George Stephanopoulos, Michael Strahan, Lara Spencer
CBeebies Bedtime Story (2009– )
Even Superheroes Have Bad Days
Star: Chris Evans
CBeebies Bedtime Story (2009– )
Goodnight World
Star: Chris Evans
The Talk (2010– )
Octavia Spencer & Chris Evans/Rocky Carroll
TV-14 | Talk-Show
Actors Octavia Spencer and Chris Evans (Gifted (2017)); actor Rocky Carroll (NCIS (2003)).
Stars: Julie Chen, Sara Gilbert, Sharon Osbourne, Aisha Tyler
Made in Hollywood (2005– )
Smurfs: The Lost Village/Going in Style/Colossal/Gifted
Interviews with the cast and filmmakers of Smurfs: The Lost Village (2017), Going in Style (2017), Colossal (2016), Gifted (2017).
Directors: Josh Neufeld, Todd Szuch | Stars: Patrick Stinson, Julie L. Harkness, Kylie Erica Mar, Ann-Margret
22. Captain America: Civil War (2016)
PG-13 | 147 min | Action, Adventure, Sci-Fi
Political involvement in the Avengers' activities causes a rift between Captain America and Iron Man.
Directors: Anthony Russo, Joe Russo | Stars: Chris Evans, Robert Downey Jr., Scarlett Johansson, Sebastian Stan
Votes: 464,482 | Gross: $408.08M
23. Chelsea (2016– )
TV-MA | 30 min | Talk-Show
Chelsea Handler interviews a number of celebrities, academics and professionals in her new show on Netflix.
Stars: Chelsea Handler, Jeff Wild, Daniel Maurio, Bryce McLeay
Votes: 1,637
24. The 88th Annual Academy Awards (2016 TV Special)
TV-14 | 217 min
The 88th Academy Awards ceremony honors achievement in film in 2015.
Director: Glenn Weiss | Stars: Chris Rock, Emily Blunt, Charlize Theron, Tom McCarthy
Votes: 1,704
25. 73rd Golden Globe Awards (2016 TV Special)
The Hollywood Foreign Press Association's 73rd annual event honoring excellence in film and television, hosted by Ricky Gervais.
Director: Louis J. Horvitz | Stars: Ricky Gervais, Channing Tatum, Jonah Hill, Jane Fonda
Votes: 677
26. IMDb First Credit (2016– )
2 min | Biography
Actors, directors, and more share anecdotes about their first IMDb credit.
Stars: Christian Bale, Kate Beckinsale, Cate Blanchett, Steve Carell
Votes: 69
27. 2016 MTV Movie Awards (2016 TV Special)
In a world of award shows that suck, MTV gives you an award show that doesn't suck. Kevin Hart and Dwayne "The Rock" Johnson host the 2016 MTV Movie Awards, an irreverent, in-your-face celebration of the movies fans really love with the stars they actually care about. And unlike other award shows, the fans choose the winners, not some exclusive committee of old, rich people. The show includes ... See full summary »
Director: Glenn Weiss | Stars: Dwayne Johnson, Kevin Hart, Miles Teller, Daisy Ridley
Votes: 135
28. Marvel's Captain America: 75 Heroic Years (2016 TV Movie)
Documentary, History
Marvel celebrates the history of Captain America, both in the comics and on TV and film, and examines the character as a reflection of American culture throughout the years.
Director: Zak Knutson | Stars: Axel Alonso, Hayley Atwell, Chloe Bennet, Tom Brevoort
Votes: 279
29. Captain America: The Road to Civil War (2016 Video)
4 min | Documentary, Short
A more detailed look at Cap's role in the fracture and Chris Evans' performance of the iconic Avenger.
Stars: Joe Russo, Anthony Russo, Chris Evans, Kevin Feige
Votes: 11
30. Nickelodeon Kids' Choice Awards 2016 (2016 TV Movie)
69 min | Family
The kids choice awards is when kids vote for their favorite things from TV shows, movies, books.. and it's usually a blast!!!
Directors: Joe DeMaio, Chris Valenziano | Stars: Blake Shelton, Brandon Alexander, Anthony Anderson, Brent Anthony
Votes: 30
31. United We Stand, Divided We Fall: The Making of 'Captain America: Civil War' (2016 Video)
46 min | Documentary
A two part feature. Part 1 (22:25) features cast and crew looking back at the story's comic book origins and discussing the story's thematic depth and relevance, the large assortment of ... See full summary »
Stars: Kevin Feige, Chris Evans, Joe Russo, Louis D'Esposito
Votes: 12
32. Iron Man: The Road to Civil War (2016 Video)
4 min | Documentary
A closer look at Tony Stark, what influenced him to take his position in this film, and his relationship with Captain America.
Stars: Kevin Feige, Robert Downey Jr., Chris Evans, Joe Russo
Votes: 9
IMDb First Credit (2016– )
Brace Yourself for Chris Evans' Adorable First Credit
Chris Evans first role was a dream for any teenager -- because he had his braces removed to play the part. Find out more about his adorable first role!
Star: Chris Evans
Votes: 7
Made in Hollywood (2005– )
Captain America: Civil War/A Bigger Splash/Joy
Interviews with the cast and filmmakers of Captain America: Civil War (2016), A Bigger Splash (2015) and Joy (2015).
Stars: Patrick Stinson, Julie L. Harkness, Kylie Erica Mar, Paul Bettany
Ellen: The Ellen DeGeneres Show (2003– )
Chris Evans & Elizabeth Olsen/Macey Hensley
TV-G | Comedy, Talk-Show
Chris Evans and Elizabeth Olsen (Captain America: Civil War (2016)); 6-year-old presidential expert Macey Hensley.
Director: Liz Patrick | Stars: Ellen DeGeneres, Chris Evans, Elizabeth Olsen, Macey Hensley
Birthday Stories with Lynn Hirschberg (2015– )
Chris Evans' Favorite Birthday
Director: Lynn Hirschberg | Stars: Chris Evans, Lynn Hirschberg
Jimmy Kimmel Live! (2003– )
Chris Evans, Sebastian Stan, Anthony Mackie & Paul Rudd/White Denim
TV-14 | Comedy, Music, Talk-Show
Chris Evans, Sebastian Stan, Anthony Mackie and Paul Rudd (Captain America: Civil War (2016)). Also: White Denim perform.
Directors: Zack Bornstein, Jonathan Kimmel | Stars: Jimmy Kimmel, Chris Evans, Sebastian Stan, Anthony Mackie
Votes: 12
The Tonight Show Starring Jimmy Fallon (2014– )
Chris Evans/Marc Maron/Little Big Shots/Lecrae
TV-14 | 41 min | Comedy, Music, Talk-Show
Chris Evans (Captain America: Civil War (2016)); Marc Maron (Maron (2013)). Also: Child performers from Little Big Shots (2016) are spotlighted; Lecrae sits in with The Roots.
Director: Dave Diomedi | Stars: Jimmy Fallon, Chris Evans, Marc Maron, Lecrae
Votes: 14
Made in Hollywood (2005– )
Deepwater Horizon/The Dressmaker
Interviews with the cast and filmmakers of Deepwater Horizon (2016) and The Dressmaker (2015).
Directors: Josh Neufeld, Todd Szuch | Stars: Patrick Stinson, Julie L. Harkness, Kylie Erica Mar, Chris Evans
Chelsea (2016– )
Dinner Party: Captain America & Friends
TV-MA | 34 min | Talk-Show
Several of the cast members of Captain America: Civil War (2016) including Chris Evans and Chadwick Boseman' discuss the film as well as other projects.
Stars: Chelsea Handler, Chadwick Boseman, Amy Dallen, Chris Evans
Votes: 66
Entertainment Tonight (1981– )
Episode #35.128
The funeral of Nancy Reagan; behind the scenes of Captain America: Civil War (2016), with Chris Evans; the new cast of Allegiant (2016). Also: the premiere of 10 Cloverfield Lane (2016); interviews with Marcia Clark, Sheryl Underwood, Padma Lakshmi.
Stars: Nancy O'Dell, Kevin Frazier, Samantha Harris, Nischelle Turner
Dish Nation (2011– )
Episode #4.175
TV-PG | 30 min | News
Stars: Rickey Smiley, Gary With Da Tea, HeadKrack, Porsha Williams
WGN Morning News (1994– )
Episode dated 4 May 2016
Stars: Marcia Clark, Chris Evans, Aldis Hodge, Jeff Selingo
Good Morning America (1975– )
Episode dated 5 April 2016
TV-G | News, Talk-Show
Cameron Diaz; Sarah Paulson (American Crime Story (2016)); a visit to the set of Captain America: Civil War (2016); Candace Cameron Bure (The View (1997) and Fuller House (2016)); Jessica Seinfeld; a couple voted off Dancing with the Stars (2005).
Stars: Candace Cameron Bure, Ron Claiborne, Cameron Diaz, Robert Downey Jr.
Good Morning America (1975– )
Episode dated 5 May 2016
TV-G | News, Talk-Show
Chris Evans (Captain America: Civil War (2016)); Geena Davis ("Thelma and Louise" (1991)); highlights from the Bentonville Film Festival; "Deals and Steals on Wheels" with Tory Johnson.
Stars: Ron Claiborne, Geena Davis, Chris Evans, Paula Faris
Made in Hollywood (2005– )
Money Monster/The Darkness/The Lobster/Captain America: Civil War
Interviews with the cast and filmmakers from Money Monster (2016), The Darkness (2016), The Lobster (2015) and Captain America: Civil War (2016).
Directors: Josh Neufeld, Todd Szuch | Stars: Patrick Stinson, Julie L. Harkness, Kylie Erica Mar, Paul Bettany
47. Avengers: Age of Ultron (2015)
PG-13 | 141 min | Action, Adventure, Sci-Fi
When Tony Stark and Bruce Banner try to jump-start a dormant peacekeeping program called Ultron, things go horribly wrong and it's up to Earth's mightiest heroes to stop the villainous Ultron from enacting his terrible plan.
Director: Joss Whedon | Stars: Robert Downey Jr., Chris Evans, Mark Ruffalo, Chris Hemsworth
Votes: 555,273 | Gross: $459.01M
48. Ant-Man (2015)
PG-13 | 117 min | Action, Adventure, Comedy
Armed with a super-suit with the astonishing ability to shrink in scale but increase in strength, cat burglar Scott Lang must embrace his inner hero and help his mentor, Dr. Hank Pym, plan and pull off a heist that will save the world.
Director: Peyton Reed | Stars: Paul Rudd, Michael Douglas, Corey Stoll, Evangeline Lilly
Votes: 404,251 | Gross: $180.20M
49. The 87th Annual Academy Awards (2015 TV Special)
TV-14 | 223 min
The Academy of Motion Picture Arts and Sciences celebrates the year's achievements in film.
Director: Hamish Hamilton | Stars: Neil Patrick Harris, Anna Kendrick, Jack Black, Lupita Nyong'o
Votes: 3,392
50. 2015 MTV Movie Awards (2015 TV Special)
Comedy, Music, Reality-TV
In the biggest movie awards show event of the season, MTV gathers a large selection of stars to entertain.
Director: Ryan McFaul | Stars: Amy Schumer, Channing Tatum, Vin Diesel, Reese Witherspoon
Votes: 252


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Therapeutic Vaccination for Patients With HPV16+ Cervical Intraepithelial Neoplasia (CIN2/3)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00988559
Recruitment Status : Recruiting
First Posted : October 2, 2009
Last Update Posted : March 10, 2016
Sidney Kimmel Comprehensive Cancer Center
National Institutes of Health (NIH)
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Sidney Kimmel Comprehensive Cancer Center
|Tracking Information
|First Submitted Date ICMJE
|October 1, 2009
|First Posted Date ICMJE
|October 2, 2009
|Last Update Posted Date
|March 10, 2016
|Start Date ICMJE
|September 2009
|Estimated Primary Completion Date
|September 2016 (Final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|To evaluate feasibility and toxicity in women with CIN2/3 caused by HPV16 [ Time Frame: 2 years ]
|Original Primary Outcome Measures ICMJE
|Same as current
|Change History
|Complete list of historical versions of study NCT00988559 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|To compare immunogenicity of three different routes of administration: intradermal (ID), intramuscular (IM), and intralesional (IL) [ Time Frame: 2 years ]
|Original Secondary Outcome Measures ICMJE
|Same as current
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Therapeutic Vaccination for Patients With HPV16+ Cervical Intraepithelial Neoplasia (CIN2/3)
|Official Title ICMJE
|A Pilot Study of pnGVL4a-CRT/E7 (Detox) for the Treatment of Patients With HPV16+ Cervical Intraepithelial Neoplasia 2/3 (CIN2/3)
|Brief Summary
|This study will test the efficacy and safety of different routes of administration of a DNA vaccine in patients with HPV16+ CIN2/3. Subjects will be enrolled in one of six treatment groups. Subjects enrolled in the first two groups will receive vaccination intradermally with a needle-free delivery device. Subjects enrolled in groups 3 and 4 will receive vaccination intramuscularly. Subjects enrolled in groups 5 and 6 will receive vaccine intralesionally.
|Detailed Description
Primary Objectives
Secondary Objectives:
|Study Type ICMJE
|Study Phase
|Not Provided
|Study Design ICMJE
|Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Condition ICMJE
|Intervention ICMJE
|Study Arms
|Publications *
|Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Estimated Enrollment ICMJE
|Estimated Completion Date
|March 2017
|Estimated Primary Completion Date
|September 2016 (Final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria:
Exclusion Criteria:
|18 Years and older (Adult, Senior)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Listed Location Countries ICMJE
|United States
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
P50CA098252 ( U.S. NIH Grant/Contract )
1R21CA128232 ( U.S. NIH Grant/Contract )
|Has Data Monitoring Committee
|U.S. FDA-regulated Product
|Not Provided
|IPD Sharing Statement
|Responsible Party
|Sidney Kimmel Comprehensive Cancer Center
|Study Sponsor ICMJE
|Sidney Kimmel Comprehensive Cancer Center
|Collaborators ICMJE
|Investigators ICMJE
|PRS Account
|Sidney Kimmel Comprehensive Cancer Center
|Verification Date
|March 2016
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


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Wedding Celebration Officiant in and around Belen, New Mexico.
Life's Moments are those times in life that we decide to make an unique recognition of life changing events. Weddings are celebrations, weddings are ceremonies, yet above all weddings are a new beginning, a moment in time to be valued. Having the best Wedding Officiant is essential.
For these moments, we provide extensive Wedding Officiant services, Scottish Wedding Ceremony officiating, and also wedding event solutions. From the very standard to modern solutions, our wedding celebrations and also officiating services are created to reflect your desires, dreams and desires. We will assist you to craft an occasion, secular or spiritual that will be a valued memory for many years to come.
Ministerial services as well as wedding officiating in the Belen, New Mexico area is our specialty, but we could travel if the requirement occurs. We supply a total selection of Scottish Wedding Ceremony plans; from elopement on the courthouse steps to the most elaborate formal wedding you might want.
We additionally offer the finest in Justice of the Peace or secular weddings. These civil ceremonies provide their own kind of celebration, whether it be with family members or simply a couple as well as a couple of witnesses, your wedding event is a special moment to be treasured.
Bruce Byers All rights reserved. Design by Bruce Byers


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$90K Farm to School
Regional Grant Competition
Congratulations to the Western Slope for winning the competition. To learn more about the region and how it will use the grant, read here. Check out the great media coverage, including a Denver Post article by Colleen O'Connor.
Early 2016, the Colorado Farm to School Task Force and CoBank announced a competitive regional grant program to grow farm to school sales. Three regions vied for $90,000 to support the development and implementation of on-farm food safety plans for Colorado fruit and vegetable producers who want to sell to Colorado schools. Learn more about the grant competition below.
2016 Eligible REGIONS
- Western Slope (counties include Delta, Mesa, Montrose, Ouray, San Miguel, and Gunnison).
- Northern Front Range (counties include Adams, Arapahoe, Denver, Douglas, Jefferson, Broomfield, Weld, Boulder, and Larimer).
- Southern Front Range (counties include El Paso, Pueblo, Custer, Fremont, Teller, Huerfano, Crowley, and Otero).
Who Applied
The application was simple; however, to apply a region had to demonstrate that they have a minimum of two school districts, five producers, and one community organization (e.g., local health department, local/regional food policy council, non-profit working on local food issues, etc.) willing to work together on FTS.
Process for Applying
Applications were available at the Colorado Farm to School Intensive Technical Assistance (ITA) Workshops in each region and could also be downloaded online (Word, PDF). At least some of the applicants (school food service directors, agricultural producers, community partner) had to attend the ITA workshops in their region.
Why a Grant for On-Farm Food Safety?
Many small to mid-size producers sell directly to consumers, such as farmers' markets; however, selling to schools and other institutional buyers, including distributors and other wholesale operations requires producers to have formal farm food safety plans. This poses a significant increase in cost and time to the producer. The $90K regional grant will provide "mini-grants" up to $10K for individual producers and $15K for food hubs/co-ops.


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- HubPages»
- Games, Toys, and Hobbies»
- Computer & Video Games»
- Roleplaying Video Games»
- Western Roleplaying Video Games
Fallout New Vegas Sniper Rifles
Sniping in Fallout New Vegas is a lot of fun, and while many rifles in the game can be modified with a long range scope, that's just not the same as the real deal.
Here's a little bit about the Sniper Rifles that are available to you. Find them/buy them and start wreaking havoc from a distance, no modification required.
- Has the highest Critical Chance multiplier of all the Sniper Rifles at x5
- Can be repaired with standard Varmint Rifles
- Uses 5.56 Ammo
- Is equally the lightest Sniper Rifle when picked up at 4.5 kg's (standard Sniper Rifle can be modded to be lighter)
The Ratslayer may very well be the first Sniper Rifle you find in New Vegas, and it also has lowest attribute requirements, of all of the New Vegas Sniper Rifles requiring only a Strength of 3 for Optimal use. You can find it in Broc Flower Cave (roughly between Novac and Camp Searchlight) which is not all that difficult for a low level character to get to in the early stages of a game. The Ratslayer is a Unique fully modified Varmint Rifle that is slightly more powerful than the standard Varmint Rifle.
- Is Locked in a Very Hard Footlocker requiring a Lockpick skill of 100 to open.
- Requires Guns skill of 75 and Strength of 6 for optimal use
- Uses .308 ammo
- Can be repaired with standard Sniper Rifles.
- Condition deteriorates slower than other Sniper Rifles.
- Is the most valuable Sniper Rifle in the game.
Gobi Campaign Scout Rifle
Another Unique weapon. The Gobi Campaign Scout Rifle is a pre modded variant to the Sniper Rifle and is located not too far from Broc Flower Cave at the Snipers Nest. It can be obtained early on in the game. While it comes modded, it cannot be silenced. A single shot does slightly less damage than a standard sniper, however with a slightly quicker reload time it can do a little more damage over time.
- Can be modified with Sniper Rifle Suppressor to reduce Noise, and Sniper Rifle Carbon Fibre Parts Reducing its weight to 3 kg.
- Requires Guns skill of 75 and Strength of 6 for optimal use.
- Can be repaired with other standard Sniper Rifles
- Uses .308 ammo
- Has the smallest magazine capacity of all the Sniper Rifles of 5 rounds.
Sniper Rifle
The standard Sniper Rifle can be found in a few locations in New Vegas, however these are locations mean that the player will almost certainly be between level 10 and 20 (depending on play style) before these locations are reached. Camp McCarran and Vault 34 are probably the first 2 locations you will come across where Sniper Rifles can be looted from. These destinations are very very difficult to get to alive as a low level (below level 10) character. It comes as no surprise then, that you cannot purchase a Sniper Rifle until you are at least level 11, from the Gun Runners, or Level 14 to buy one for 188 Trading Post.
- Requires Guns skill of 100 and Strength of 6 for optimal use
- Uses 5.56 ammo
- Is repaired with other Marksman Carbines
- inflicts the second highest amount of Damage Per Second of all of the Sniper Rifles.
Marksman Carbine
A semi-automatic carbine with scope attached, means high speed sniping, which is good for dealing with moving targets. It also means that the Marksman Carbine is more than handy when the fight gets a little bit more up close and personal. You can buy one from the Gun Runners after hitting level 16, and also from the Brotherhood of Steel bunker in Hidden Valley after gaining permission to purchase weapons from their armory. You can loot the Marksman Carbine from a few locations in New Vegas, including the Vault 34 Armory, and in a room in the Nellis Array.
- Has the highest capacity magazine of all the Sniper Rifles at 24 rounds
- Inflicts the highest amount of Damage Per Second of all the Sniper Rifles
- Uses 5.56 ammo
- Requires Guns skill of 100 and Strength of 4 for optimal use
- Is the second most valuable Sniper Rifle in the game
- Can be repaired with the Marksman Carbine
All American
The All American is a unique Marksman Carbine, with a higher capacity magazine, and scope with slightly more zoom than the marksman carbine.
You will find the All American in the Armory of Vault 34, just be careful as if you go there with a human companion they may pick it up before you do, if so you can just swap it out of their inventory. The All American is a good choice for your main weapon as it is lethal at both long and short range, plus ammo is fairly common.
- Uses .357 Magnum ammo
- Has the lowest Action Point cost for VATS attacks of all Sniper Rifles in New Vegas
- Requires Guns skill of only 25 and Strength of 5 for optimal use
- Has a Critical Chance Multiplier of x1.5
- Can be repaired with Cowboy Repeater rifles
La Longue Carabine
La Longue Carabine is the last of the Unique Sniper Rifles in the game. While its skill requirements are such that it could be used by a low level player, it's location means you probably wont come across it until you have levelled up a dozen times or more. The weapon is a moddified Cowboy repeater with Scope and Extended Feeder Magazine.
This is the private and much loved weapon of NCR's Corporal Sterling, stationed at Camp McCarran with the 1st Recon Sniper Division. You will need to kill him to get the rifle, which depending on how you do it has the potential to make the whole camp hostile toward you, so be careful.
Remember Sniper's love to remain hidden, and love 1 shot kills.
Note - Completing the I Don't Hurt Anymore quest will result in Corporal Sterling and the 1st recon unit relocating to Camp Forlorn Hope.
Anti-Materiel Rifle
The big daddy of New Vegas Sniper Rifles. This 50 caliber rifle is easily the best Sniper Rifle in Fallout New Vegas when it comes damage inflicted by a single shot. However it's slow rate of fire means you only get 1 shot off roughly every 2 seconds. 1 shot while hidden will take care of a lot of foes for good, or at the least take a sizable chunk out of their chances of living much longer.
You can buy the Anti-Material rifle from a number of merchants in various states of repair, mostly not very good. Gun Runners should be able to sell a quality weapon if you have the caps. Ranger Veterans may carry Anti-Materiel Rifles, but they are almost always in poor condition. These weapons are expensive to repair and ammo is fairly hard to find, and expensive to buy (compared to other ammo types) so pick your targets well. You probably don't need to be using the Anti-Materiel rifle to take out a radroach, save it for the Deathclaws.
- Requires Guns skill of 100 and a Strength of 8 for optimal use
- Can only be repaired with other Anti-Materiel Rifles
- Uses .50 MG ammo - the most expensive ammo to buy
- A single shot can knock a target of its feet
- Is the heaviest Sniper Rifle in the game, and one of the heaviest Weapons in the game weighing 20 kg
Sniper Rifle Repair
New Vegas Sniper Rifles are not the cheapest weapons to repair, and can generally only be repaired with other Sniper Rifles. Because of this I would strongly suggest working towards getting the Jury Rigging Perk. This Perk is available to you at level 14 when you have a Repair Skill of 90 or higher. The Perk significantly increases the amount of weapons you can use to repair your Sniper Rifles and will help you keep your long range arsenal in tip top shape for the next hit.
Happy hunting.


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I am SO proud to call this beautiful little love my daughter! She is the most amazing little girl inside and out. She amazes me everyday with how caring and thoughtful she is. She always thinks about everyone else and loves to do kind things for everyone. Not only is she beautiful, but she is also incredibly talented as well. She is the most elegant, dreamy dancer I have ever seen and she puts a lot of hard work and passion into dance. I cannot believe how grown up she is and I am SO proud to be her mama. I love you Brynlee!
Enjoy this dreamy outdoor shoot! The amazing floral crown and bouquet is from the most amazing local florist By Bloomers. Kathy is the most talented florist I have ever seen. She is so creative and wonderful to work with. She took my ideas and executed them beyond what I could've ever dreamed of. The beautiful dress is from Tutu Du Monde


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Recently, I have been playing an online game, currently in alpha testing, called Exploit: Zero Day and I have to say it has definitely been an enjoyable experience. EZD was created by Future Proof Games, who also did Ossuary, which I have previously reviewed. The game itself has a great concept. Basically, you are a part of this group called Zero Day, they are your modern tech savvy Robin Hood and his merry men. A group of hackers that steal from the rich and give to the poor; the voice of the silenced. EZD does a great job of making a compelling story and backstory with this concept. Future Proof Games pays very close attention to detail making the story believable. For example, your main adversary in the game is the company, Samsara Digital, and there is an actual website to accompany the business, breathing life into the fictional company. The narrative also allows for roleplaying as you can choose how to respond to those you are in contact with, are you going to look the other way or speak up? Who will you work for and against?
As I have mentioned, throughout the game you take on the role of a hacker. The way you hack into different systems is through the successful solution of puzzles or as they are called in EZD, clusters. The clusters are extremely enjoyable and just the right amount of challenging that you do not become overwhelmed and want to quit. Many, if not all, of the clusters rely heavily on timing in order to achieve completion. A split second can determine whether or not you have successfully hacked the system. Due to my touchscreen capabilities on my laptop, I completed many of the clusters through touch, and because I loved the capability I began playing EZD on my iPhone as well.
Not only can you try and solve the clusters given to you throughout the game, but you can also create your own. If you are a designer or creative person or think you can make a better cluster than the ones given, then you should definitely try out the creation tool and possibly share your clusters with others to have them test them out and give you feedback. Being able to share is another side aspect of EZD, as there is a forums section. Although the forums are used for system errors and bugs, as the game is still in its developmental stages, there are also many opportunities to socialize. Personally, I did not get much into socializing within the community of EZD, but it is definitely a feature that I know many people appreciate.
After playing EZD for a while, I reached out to the co-founder and VP of Future Proof Games, Melissa Avery-Weir. I asked her a few questions in regards to EZD and here were her responses, many of which made me want to get back on the game as quickly as possible.
What was the inspiration behind EZD?
It's the sequel to Gregory's 2009 Flash game "Exploit" (http://futureproofgames.com/games/exploit/). One of the things people enjoyed in that game was the ability to create and share their own puzzles, even though that was something of an afterthought in the game.
With EZD, we felt like we could take the idea of puzzle sharing and the original cyberpunk themes of social justice, and have an interesting, community-driven game. It's a bit of an experiment, which is exciting! There aren't a lot of other games trying to tell stories like this; we're inspired by the format of Fallen London (http://fallenlondon.storynexus.com/) and by games like Uplink.
Why was EZD created as an online game, rather than going through Steam as was done with Ossuary?
A major advantage to EZD being a browser-based game allows for it to be smartphone friendly without having to release the game separately for each device. Folks can currently play and create clusters and systems and post on the forums on desktop, tablet, or smartphone, and we plan to keep that going.
Similarly, the game is always accessible and always up to date. We can roll out updates on our own schedule and know that everyone is having the latest experience. No worrying about the last time folks updated the software on their phones.
This also lets us have the forums integrated into the game. There's more development for us to do there, but we want the roleplaying on the forums to feel like an integral part of the game.
How did you come up with the back stories and scenarios to go along with the puzzles?
We spent a decent amount of time conceiving of this fictional company Samsara Digital: figuring out their history, what they do, what the public/player knows, and what things should be slowly revealed to the players. That gives us a lot of fodder for stories, even ones not directly related to Samsara.
We also pull from relatively currently events. When major hacks happen or major political or social injustices — we note down moral aspects of those that we want to explore in the game. We're exploring police militarization in a story I'm currently creating puzzles for, for instance, and that's inspired in part by events in Ferguson. We're exploring socioeconomic disparity, race, and police bodycams.
We don't want any company or person in the game to be wholly good or evil, and as soon as we ask ourselves, "So why are they doing this good/evil thing?" stories we write gain nuance.
When we write these stories, we try to find ways for the players to express their characters' opinions. If we set up a story in which an otherwise "good" person is doing something unpleasant, we might offer the players the chance to expose their bad deed, stop them, or let them continue. We can use the sum of the choices players made to influence future plots we write.
Other than reporting system bugs what purpose do the forums hold?
It's a place for players to roleplay, share puzzles and stories of their own, and exchange ideas. Here are some posts along those lines:
https://forum.exploitzeroday.com/t/please-help-me-decode-this/101?u=melissa: A cluster + cryptographic story kicked off by a non-player character, but solved by players
https://forum.exploitzeroday.com/t/the-other-type-of-cracking/142?u=melissa: A player-written narrative
https://forum.exploitzeroday.com/t/adaptive-systems/102?u=melissa: Deliberately tricky set of systems
We want to foster a welcoming community where folks can ask for help, start stories, and post without fear of being ridiculed for a lack of skill.
All in all, Exploit: Zero Day is a great game, it has an interesting storyline and an easy to pick up yet still challenging gameplay. Due to the fact that this is online EZD has plenty of opportunities to expand in new and exciting ways. I would encourage you all to try it out and see for yourself. Personally, I cannot wait to see what the future holds for this game. EZD is most definitely a game that I will keep coming back to.
From Melissa:
Folks can get access by joining the mailing list https://exploitzeroday.com/accounts/mailing-list/. We send out newsletters at the end of each month.
© 2015 – 2016, www.zero1gaming.com. All rights reserved. On republishing this article your must provide a link to this original post
Taylor Barkley
It's actually quite simple. I love writing. I love playing video games. So, why not combine the two? When I'm not focusing on my academics, I'm either writing or playing video games. As a writer and avid reader I love a good story, because of this I tend to lean towards games that have a strong narrative aspect. Currently, I am studying Computer Science and Game Design in North Carolina. My ultimate goal being to one day make a name for myself in the game narrative field.
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Probucol Attenuates Left Ventricular Dysfunction and Remodeling in Tachycardia-Induced Heart Failure
Roles of Oxidative Stress and Inflammation
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Background— Oxidative stress and inflammation are potentially involved in the pathogenesis of heart failure (HF). We examined whether antioxidant and antiinflammatory treatment with probucol decreases myocardial oxidative stress and inflammation and attenuates the progression of left ventricular (LV) dysfunction and remodeling (dilatation) in tachycardia-induced HF.
Methods and Results— We studied 3 groups of dogs: a sham-operated control group and 2 other groups that underwent ventricular pacing at 240 bpm with and without probucol treatment (100 mg/kg IP per week) for 4 weeks. Dogs that underwent ventricular pacing for 4 weeks developed signs of HF, such as a reduction in the LV ejection fraction and increases in the LV end-diastolic dimension and LV end-diastolic pressure. Myocardial oxidative stress, as measured by electron spin resonance spectroscopy with 4-hydroxy-2,2,6,6,-tetramethyl-piperidine-N-oxyl (hydroxy-TEMPO), was significantly increased. There was an increase in myocardial monocyte infiltration, monocyte chemoattractant protein-1 expression, and renin-angiotensin system and matrix metalloproteinase activity. Probucol treatment prevented increases in oxidative stress, inflammation, and matrix metalloproteinase activity and attenuated LV dysfunction and remodeling.
Conclusions— Probucol attenuated LV dysfunction and remodeling, possibly through its antioxidant and/or antiinflammatory effects in ventricular pacing–induced HF. These data suggest that inflammatory disorders, which cause an abnormal interaction between failing myocardium and activated monocytes, have an important role in the progression of HF.
Received March 4, 2002; revision received April 24, 2002; accepted April 24, 2002.
Heart failure (HF) is a serious clinical syndrome with progressive myocardial dysfunction and a poor clinical outcome. Changes in the ventricular geometry (remodeling) are recognized to be a major determinant for the development of impaired ventricular function and a poor prognosis. The mechanisms responsible for the progression of HF and remodeling, however, remain to be elucidated.
Recent evidence suggests that oxidative stress might be involved in the pathogenetic processes in HF.1,2⇓ Myocardial oxidative stress and/or inflammation increase in hypertrophied or failing myocardium. There is ample evidence that oxidative stress activates redox-sensitive transcription factors and induces transcription of proinflammatory cytokine (tumor necrosis factor-α, interleukin-6) and chemokine (monocyte chemoattractant protein [MCP]-1, interleukin-8) genes.3–6⇓⇓⇓ In particular, recent evidence suggests that the infiltration/activation of monocytes contributes to the development of left ventricular (LV) remodeling and failure. For example, increased monocyte infiltration into failing myocardium, MCP-1 expression, and increased serum concentration of MCP-1 are observed in animals and humans with HF.7–9⇓⇓ Elevated circulating levels of MCP-1 correlate with the severity of HF.4 Transgenic mice overexpressing MCP-1 in the myocardium develop myocarditis and subsequent LV remodeling and HF.10 The role of oxidative stress and/or inflammation during HF progression, however, has not been fully addressed. Elucidation of the mechanisms of the interaction between activated monocytes and myocardium is important, because activated monocytes are a major source of oxidative stress, proinflammatory cytokines, and matrix metalloproteinases (MMPs).11 Previous studies reported increased myocardial MMP activity in animal and human models of HF.12 An MMP inhibitor or absence of MMP limits LV remodeling after myocardial infarction.13,14⇓ Angiotensin II, which is central to the pathogenesis of HF, also induces oxidative stress and MCP-1 gene expression in vitro and in vivo.15,16⇓
Recent studies demonstrated that myocardial oxidative stress increases in noninfarcted myocardium after myocardial infarction in mice and that antioxidant treatment with dimethylthiourea attenuates LV remodeling and failure.17 Sia et al18 reported that antioxidant treatment with probucol improved survival in rats with large myocardial infarction associated with reduced cardiac fibrosis and expression of inflammatory cytokines. To the best of our knowledge, however, no previous study has addressed the role of oxidative stress in the development of LV dysfunction and remodeling in tachycardia-induced HF. Tachycardia-induced HF serves as a useful experimental model for study of the pathogenesis of human dilated cardiomyopathy, because it produces a well-defined syndrome of biventricular HF and activation of neurohormonal factors, including the renin-angiotensin system, which mimics human dilated cardiomyopathy.19 In the present study, we examined whether treatment with probucol attenuates myocardial oxidative stress and inflammation (monocyte infiltration, MCP-1 expression) and MMP activity and thereby inhibits the progression of LV dysfunction and remodeling in a canine model of tachycardia-induced HF.
Animal Model of Pacing-Induced HF
This study was approved by the Committee for the Ethics of Animal Experiments and was conducted according to the animal care guidelines of the American Physiological Society. A part of this study was performed at the Kyushu University Station for Collaborative Research.
Experiments were performed in adult mongrel dogs (18 to 22 kg body weight; Kyuda, Fukuoka, Japan). Under general anesthesia and fluoroscopic guidance, a bipolar pacing lead (1452T/58, Pacesetter AB) was placed in the apical area of the right ventricle. Ventricular pacing was then performed at 240 bpm continuously for 4 weeks. Before and 7, 14, and 21 days after ventricular pacing began, dogs were randomly assigned to receive an intraperitoneal injection of PBS (HF+PBS group) or 100 mg/kg probucol (HF+probucol group). PBS or probucol was injected after the echocardiographic study was completed. Probucol scavenges superoxide20 and inhibits oxidative modification of low-density lipoprotein.21 This dose of probucol was chosen because intraperitoneal injection of probucol at doses ranging from 12.5 to 120 mg/kg every 3 to 7 days prevents doxorubicin-induced oxidative stress and myocardial dysfunction in rats and dogs.22,23⇓ Intraperitoneal injection was selected because probucol is poorly absorbed from the gastrointestinal tract, with only 2% to 8% of the dose reaching the circulation. To determine whether probucol reached the myocardial tissues, we measured the probucol concentration in the myocardial tissues using high-performance liquid chromatography.24 The probucol concentration in myocardial tissues after 28 days of pacing (7 days after the 4th injection of probucol) was 21.9±2.0 μg/g wet tissue. Control dogs were treated in the same manner as HF dogs without pacing.
Echocardiography and Hemodynamic Measurements
Before and after 1, 2, 3, and 4 weeks of pacing, the 3 groups of dogs underwent echocardiographic examinations while conscious and in sinus rhythm, after a 15-minute stabilization period. The internal LV dimensions and the wall thickness of the LV were measured with an ultrasonograph (SSH-160A, Toshiba Medical Inc).3 The LV ejection fraction (percent) was then calculated.3
After 4 weeks of ventricular pacing, venous blood was sampled from the antecubital vein of conscious dogs for measurement of hormonal factors. The animals were then anesthetized with pentobarbital and ventilated with a respirator. After thoracotomy, aortic pressure, heart rate, LV pressure, and the positive first derivative of LV pressure (LV dP/dt) were recorded with a polygraph (RM-6000, Nihon-Kohden) while animals were in sinus rhythm.3 Dogs were then killed by an overdose of pentobarbital, and the hearts were excised for histopathological and biochemical analysis.
Measurement of Myocardial Oxidative Stress
As we described previously, myocardial oxidative stress (·OH originating from O2− and H2O2) was measured by the electron spin resonance (ESR) method.3,25⇓
Northern Blot Analysis
Immediately after the hemodynamic measurements, the hearts were removed, snap-frozen in liquid nitrogen, and stored at −80°C. Total RNA was extracted from each sample by the acid guanidinium thiocyanate–phenol-chloroform method. Northern blot hybridization was performed as described previously.26 The cDNA probes used included dog MCP-1 (a gift of Dr Leonardo Mendoza, Baylor College of Medicine, Waco, Tex). Relative amounts of MCP-1 were normalized against the amount of GAPDH mRNA.
Immunohistochemistry was performed with frozen OCT compound–embedded sections and antibodies against monocyte (AM-3K),27 neutrophil (SG8H6),28 T lymphocyte (CD3, Dako), MCP-1 (Catalog No. 43279, Genzyme), or nonimmune IgG. The slides were washed and incubated with biotinylated, affinity-purified goat anti-mouse IgG as the secondary antibody. After avidin-biotin amplification, the slides were incubated with 3,3′-diaminobenzidine and counterstained with hematoxylin.
Myocardial MMP Activity and Tissue ACE Activity
MMP activity in the myocardial tissue was measured with gelatin zymography according to methods described previously.17 Briefly, the samples extracted from LV myocardium were loaded directly onto electrophoretic gels (SDS-PAGE) containing 1 mg/mL of gelatin under nonreducing conditions. Myocardial tissues of the LV free wall were isolated, and the ACE activity was measured by fluorometric assay as previously described.29
Neurohormonal Factors
Plasma atrial natriuretic peptide, plasma renin activity, and angiotensin II levels were determined with commercially available kits.
Statistical Analysis
Data are expressed as mean±SEM. Differences between 3 experiments were determined by 2-way ANOVA and Bonferroni's multiple comparison test. A value of P≤0.05 was considered statistically significant.
Hemodynamics and Echocardiography
Hemodynamic parameters after 4 weeks of pacing are summarized in Table 1. Heart rate was similar in the control, HF+PBS, and HF+probucol groups. Mean aortic pressure was significantly decreased in the HF+PBS and HF+probucol groups compared with control groups. LV end-diastolic pressure was significantly elevated and LV dP/dt was decreased in the HF+PBS group and attenuated in the HF+probucol group.
Serial echocardiographic examination revealed progressive LV dilatation and contractile impairment in the HF+PBS group (Figure 1A). Table 2 summarizes the data for echocardiographic measurements after 4 weeks for each group. These changes were attenuated in the HF+probucol group. LV end-diastolic diameter increased and LV ejection fraction decreased in a time-dependent manner in the HF+PBS group (Figure 1, B and C). Probucol treatment significantly inhibited the increase in LV end-diastolic diameter and the decrease in LV ejection fraction after 2, 3, and 4 weeks of pacing.
Myocardial Oxidative Stress
ESR spectroscopy signals of 4-hydroxy-2,2,6,6-tetramethyl-piperidine-N-oxyl (hydroxy-TEMPO) declined more rapidly in HF dogs than in controls, and there was a linear relation in the semilogarithmic plot of peak signal intensity versus time. As we reported previously,25 the decay rate of ESR signals of hydroxy-TEMPO did not differ between the control and HF+PBS group after 2 weeks of pacing. At 4 weeks, the decay rate was significantly greater in the HF+PBS group than in controls (Figure 2). The increased decay rate was attenuated by probucol treatment (Figure 2).
AM-3K–Positive Monocyte Infiltration and MCP-1 Expression
After 4 weeks, MCP-1 mRNA expression in the myocardial tissues was not detected in the control group but was markedly increased in the HF+PBS group. The increased expression of MCP-1 mRNA was significantly suppressed by probucol treatment (Figure 3, A and B). There was intense staining of immunoreactive MCP-1 in the endothelial layers (possibly endothelial cells) and infiltrated monocytes (Figure 3C).
AM-3K–positive monocytes diffusely infiltrated the interstitial space of the myocardium in HF+PBS dogs (Figure 4A). The number of immunopositive cells per section was significantly greater in HF+PBS dogs than in controls. The increases in AM-3K positive cells were markedly reduced in the HF+probucol group (Figure 4B). The number of SG8H6-positive neutrophils and CD3-positive T lymphocytes did not differ among the 3 groups.
Neurohumoral Parameters and Tissue ACE Activity
After 4 weeks, plasma renin activity, angiotensin II, and atrial natriuretic peptide concentrations were significantly increased in the HF+PBS group. Probucol treatment markedly suppressed these increases (Table 3). Probucol treatment also reduced increased LV tissue ACE activity (Table 3).
Myocardial MMP Activity
After 4 weeks, gelatin zymography of the LV myocardial tissues revealed that MMP activity was significantly increased in the HF+PBS group and suppressed in the HF+probucol group compared with the HF+PBS group (Figure 4C).
The major new finding of the present study is that treatment with probucol attenuated myocardial oxidative stress and inflammatory processes (monocyte infiltration, MCP-1 expression, and MMP activation), as well as LV dysfunction and remodeling, in tachycardia-induced HF. These data suggest that oxidative stress and inflammation have an important role in the progression of HF.
Our group has recently provided direct evidence of increased myocardial oxidative stress in dogs with tachycardia-induced HF using the ESR method and immunohistochemical detection of lipid peroxidation.3,25⇓ Here, we report suppression of myocardial oxidative stress by probucol, indicating that probucol prevented increased myocardial oxidative stress in this dog model of HF.
Oxidative stress activates redox-sensitive transcription factors (NF-κB and activating protein-1), which in turn lead to the transcription of many inflammation-related genes. Such redox-sensitive transcription pathways are activated in HF.30 We demonstrated inflammatory cells in the failing myocardium that were exclusively AM-3K–positive monocytes, but not neutrophils or T lymphocytes. An important finding of the present study is that treatment with probucol not only attenuated LV dysfunction and remodeling but also inhibited myocardial inflammation (monocyte infiltration and MCP-1 expression). MCP-1 is now recognized to be a potent chemokine for monocyte infiltration and activation. Therefore, our present data support the hypothesis that the beneficial cardioprotective effects of probucol are a result of its antiinflammatory effects through attenuated expression of MCP-1. Further studies are needed to determine whether the cardioprotective effects of probucol are a result of its primary antiinflammatory action or its secondary antioxidant action.
Consistent with previous reports,31,32⇓ systemic and local renin-angiotensin systems were activated in our model of pacing-induced HF. Angiotensin II induces oxidative stress; activates redox-sensitive transcription, resulting in MCP-1 gene expression; and activates MMP. Another important finding is that treatment with probucol prevented increases in plasma angiotensin II levels, renin activity, and LV tissue ACE activity, suggesting that the beneficial effects of probucol can be explained by the reduction in local and circulating angiotensin II. Further studies are needed to elucidate the mechanism by which probucol prevents activation of the renin-angiotensin system.
It is generally accepted that progressive myocyte cell loss (necrotic and apoptotic cell death), reactive hypertrophy of remaining myocytes, and extracellular matrix changes (matrix degradation caused by MMP activation) contribute to progressive LV dysfunction and remodeling in HF.33 Recent data suggest that all of these pathological changes occur in tachycardia-induced HF.19 MMP activation contributes to the degradation of the extracellular matrix, which in turn leads to side-to-side slippage of myocytes and thus accounts for the LV remodeling (dilatation) in HF.34,35⇓ Spinale et al34 demonstrated that inhibition of MMP activity in pacing-induced HF limited LV dilatation and dysfunction. In the present study, treatment with probucol attenuated myocardial MMP activation in failing myocardium. The present data therefore extend our previous findings and those of others and suggest that myocardial inflammatory processes activate myocardial MMPs, which in turn leads to the development of LV dysfunction and remodeling in HF. Further studies are needed to determine whether lesional monocytes are responsible for increased MMP activity in the failing myocardium.
In summary, treatment with probucol attenuated LV dysfunction and remodeling in tachycardia-induced HF. The beneficial effect of probucol is a result of not only its inhibition of myocardial oxidative stress but also inhibition of inflammatory processes (monocyte infiltration and activation by MCP-1). The present study suggests that inflammatory processes, which cause abnormal interactions between failing myocardium and activated monocytes, are involved in the progression of HF.
This study was supported by Grants-in-Aid for Scientific Research (11470164, 11158216, 11557056) from the Ministry of Education, Science, and Culture, Tokyo, Japan; by the Ryouichi Naito Foundation for Medical Research, Osaka, Japan; and by a Research Grant from Takeda Medical Research Foundation and Takeda Science Foundation, Osaka, Japan.
- ↵Belch JJ, Bridges AB, Scott N, et al. Oxygen free radicals and congestive heart failure. Br Heart J. 1991; 65: 245–248.
- ↵Mallat Z, Philip I, Lebret M, et al. Elevated levels of 8-iso-prostaglandin F2α in pericardial fluid of patients with heart failure: a potential role for in vivo oxidant stress in ventricular dilatation and progression to heart failure. Circulation. 1998; 97: 1536–1539.
- ↵Arimura K, Egashira K, Nakamura R, et al. Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure. Am J Physiol. 2001; 280: H68–H75.
- ↵Aukrust P, Ueland T, Muller F, et al. Elevated circulating levels of C-C chemokines in patients with congestive heart failure. Circulation. 1998; 97: 1136–1143.
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- ↵Devaux B, Scholz D, Hirche A, et al. Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure. Eur Heart J. 1997; 18: 470–479.
- ↵Shioi T, Matsumori A, Kihara Y, et al. Increased expression of interleukin-1β and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload. Circ Res. 1997; 81: 664–671.
- ↵Behr TM, Wang X, Aiyar N, et al. Monocyte chemoattractant protein-1 is upregulated in rats with volume-overload congestive heart failure. Circulation. 2000; 102: 1315–1322.
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- ↵Libby P, Lee RT. Matrix matters. Circulation. 2000; 102: 1874–1876.
- ↵Spinale FG, Coker ML, Thomas CV, et al. Time-dependent changes in matrix metalloproteinase activity and expression during the progression of congestive heart failure: relation to ventricular and myocyte function. Circ Res. 1998; 82: 482–495.
- ↵Creemers EE, Cleutjens JP, Smits JF, et al. Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure? Circ Res. 2001; 89: 201–210.
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- ↵Funakoshi Y, Ichiki T, Shimokawa H, et al. Rho-kinase mediates angiotensin II–induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells. Hypertension. 2001; 38: 100–104.
- ↵Hernandez-Presa M, Bustos C, Ortego M, et al. Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-κB activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis. Circulation. 1997; 95: 1532–1541.
- ↵Kinugawa S, Tsutsui H, Hayashidani S, et al. Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress. Circ Res. 2000; 87: 392–398.
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- ↵Ide T, Tsutsui H, Kinugawa S, et al. Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium. Circ Res. 2000; 86: 152–157.
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- Probucol Attenuates Left Ventricular Dysfunction and Remodeling in Tachycardia-Induced Heart FailureRyo Nakamura, Kensuke Egashira, Youji Machida, Shunji Hayashidani, Motohiro Takeya, Hideo Utsumi, Hiroyuki Tsutsui and Akira TakeshitaCirculation. 2002;106:362-367, originally published June 24, 2002https://doi.org/10.1161/01.CIR.0000021430.04195.51
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- Probucol Attenuates Left Ventricular Dysfunction and Remodeling in Tachycardia-Induced Heart FailureRyo Nakamura, Kensuke Egashira, Youji Machida, Shunji Hayashidani, Motohiro Takeya, Hideo Utsumi, Hiroyuki Tsutsui and Akira TakeshitaCirculation. 2002;106:362-367, originally published June 24, 2002https://doi.org/10.1161/01.CIR.0000021430.04195.51Permalink:


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I added a little calla lily candleholder, the white alabaster bookends, a stick I picked up in Lake Erie 2 years ago, and a bronze statuette I bought at a library silent auction about 20 years ago.
Then I cleaned up the meat grinders and hooked them to the kitchen windowsill.
At the other end of the big window, I used a little crock I just found at Goodwill to hold a few wood spoons, and added a little cat carved from coal. The cat isn't perfect, has a few chips but that doesn't bother me. I'm not perfect either.
Copyright Susanna Holstein. All rights reserved. No Republication or Redistribution Allowed without attribution to Susanna Holstein.


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I love birthdays. I love planning them, celebrating them, and building up to them. This year was my husband's 30th birthday and my son's 4th. In all honesty, my husband's birthday has largely been overlooked since the birth of our son, but the big 3-0 was something not to be missed. We celebrated with a sibling beach trip, followed by a trip to GA to visit family, followed by my son's 4th birthday party. I was really thinking I would go more low key for my son's party this year, but as it turns out, that's just not my style.
My sweet little boy has gotten really into the Teenage Mutant Ninja Turtles, which I hate because it's just so BOYISH and rough. I was not allowed to watch that show when I was little and I am not completely in love with the idea of my son watching it. But as it turns out, I am not his only parent, and the ninja turtles were childhood favorites of my husband's.
Enter the Teenage Mutant Ninja Turtle 4th Birthday Party. (Which actually was adorable and a lot of fun!)
This year I went for simplicity and just did an evite:
The main event this year: a teenage mutant ninja turtle moonbounce. Perhaps a bit extravagant for a 4 year old's birthday party, but oh so much fun! The company we worked with was great and it was so nice to have entertainment for the kids (and adults) built in instead of coming up with a lot of home made party games as I've done in the past.
The kids also played on our swing and slide play set in the back yard and I had a bubble machine running and lots of green balloons they could play with in the yard or the moonbounce.
This year, I kept the decor simple. A few party essentials from Target like Ninja Turtle plates, cups, napkins, tablecloth and a banner made decorating easy.
I ordered two shades of green balloons and grouped them into sets of four, hanging them in the front yard, back yard, and in the dining room. I taped on printable ninja turtle masks purchased from Etsy.
A few chalk drawings and we were all set!
Mmm, one of my favorite parts. His party was at 4:00 (because he was turning 4 years old) so we were ready for dinner. Everyone knows that the ninja turtles love pizza, so 3 large pizzas from Mellow Mushroom, a few dozen pretzels and a salad were our staples. We had juice boxes and water for the kids and beer and wine in ice buckets outside for the adults.
I also made "turtle ooze": green, lime flavored jello cut into the shape of a four.
(No pizza pictures…but it was so good!)
The Cake:
I love the way his cake turned out! I ordered the cake with specific colors from a local bakery and added the turtle heads and sewer cross hatches at home.
Target made party favors easy. Everyone got a plastic cup, bubbles, a pen, stickers, and ninja turtle tattoos.
Last year for the yellow birthday party we asked all of our guests to wear yellow. This year there was no outfit requirement, but my son did have a ninja turtle shirt.
I love the way his birthday party turned out! Who knew the Teenage Mutant Ninja Turtles knew how to party?
Want to see more?
Check out the First Birthday Party: Blue and Green and Cupcakes
The Second Birthday Party: Curious George
The Third Birthday Party: A Yellow Party
*Updated September 26th, 2013: I am so honored to have received the "Best Decorations" badge from Party Pail.com for this party! I had so much fun putting it together and am so excited to know that other people liked it, too!*


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A tale of two cities revealed: The hidden deprivation in Norwich
EDP pics © 2010
Dramatic inequalities in health, employment, financial stability and even life expectancy have been revealed in Norwich.
In the city's least-affluent areas, four in 10 children live in poverty; men die 10 years before those in the most affluent; and unemployment is three times higher than elsewhere in the city.
Now councillors will set about redressing the balance and ensure a brighter future for people living in Norwich's most disadvantaged parts.
A report due to go before councillors on Thursday shows the difference in prospects between the city's most and least affluent wards, and reveals:
Four in 10 children live in poverty in Norwich's most deprived parts;
Men in the least affluent wards die 10 years before those in the most affluent;
The more than three-fold increase in unemployment rates between wards.
The report also shows full-time earnings in Norwich are a sixth lower – and falling faster – than the regional average, support services are under greater pressure than ever, with many at full capacity, and the city is "significantly" worse off than the rest of the county in key indicators.
It identifies the most vulnerable people as the young, single parents, the disabled, the elderly and those on benefits.
The report was commissioned by Norwich City Council's scrutiny committee following a presentation in September from the Norwich Foodbank, which expects to feed 5,000 people in need this year.
It draws the connection between deprivation and health inequalities, concluding that Norwich fares "significantly worse" than England and the rest of Norfolk in relation to deprivation, the proportion of children in poverty and GCSEs achieved. It has more violent crime and long-term unemployment, fewer physically active children and adults, more teenage pregnancy and more hospital stays for self-harm, drug misuse and more early deaths as a result of cancer.
The report highlights the image of Norwich as a "dynamic, contemporary city" with a prestigious university and teaching hospital, world-class research park and skilled workforce, but says that, nevertheless, it is "the second most deprived local authority area in the east of England".
It adds: "A range of data reveals the different levels of need across the city, with Mile Cross, Mancroft and Catton Grove wards showing the greatest level of need but with significant issues also present in Sewell, Thorpe Hamlet, Crome, Wensum and Bowthorpe."
Claire Stephenson, chairman of the scrutiny committee, said the findings demanded action.
"The report shows the challenges for the council, and we need to deal with them. There is a lot of work to be done.
"High unemployment and benefits being reduced are going to make the problem more difficult and put more pressure on the council as well."
Ms Stephenson acknowledged the divide between fortunes in areas of the city had been known "for years" and said the council had not managed to bridge the gap.
"There has not been any great improvement: things have not changed much," she said.
"The council needs to accept responsibility for some of that situation and put in place measures which will make a difference."
For more on this story see today's paper.


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Featured Music:
"Brother Down" by Sam Roberts
"Get Busy" by Sean Paul
"Don't Know Why" by Norah Jones
"Minuet from String Quintet in E, Op 13, No 5" composed by Boccherini
The title of this episode, Til Death, is also the title of a FOX comedy series about love, marriage and friendship which stars Brad Garrett and Joely Fisher.
The blackout that happens during the episode actually occurred. On August 14, 2003, at 4:15 EDT, the electrical grid was offline for one full day. The blackout affected an estimated 10 million people in the Canadian province of Ontario and 40 million people in eight U.S. states.
Featured Music:
"String of Blinking Light" by Paper Moon
"Grow" by Jaylene
"Capricious Life" by Marco Solo
"Girls Just Want to Have Fun"
"Hungry Eyes"
"Take On Me"
"Do You Love Me"
"Hava Nagalia"
Featured Music:
"Enchantment" by Lily Frost
"Hit Me Baby One More Time" by Danielle Lindy & Trevor Yuile
"Is It Just Spring?" by Lily Frost
"Love Can Hurt" by Tim Renwick
"No Rain" by Blind Melon
"Tubthumping" by Chumbawamba
"Every Little Thing" by Melanie Doane
The "poem" that Erica recites, Voice Aflame, is actually from the chorus of Britney Spears's 1999 hit, "Baby One More Time".
Featured Music:
"Old School" by Hedley
"Pump Up the Volume" by MARRS
"Wheat Kings" by Marco DiFelice & Trevor Yuile
"Im too Sexy" by Trevor Yuile & Joettes
"Two Princes" by Spin Doctors
"Girl WithA Problem" by The Northern Pikes
"Every Little Thing" by Melanie Doane
Quote Dr. Tom uses in this episode:
Chasing the past, she stumbled into the future. - T.A. Sachs (paraphrased)
Featured Music:
"What's Going On" by 4 Non Blondes (Erica goes back in time)
"People Are Strange" by The Doors (Erica goes to the society meeting)
"Everybody Knows" by Concrete Blonde (newspapers are read)
"What's Going On" by 4 Non Blondes (Erica joins the blockade)
Erica's previous work experience:
WTP Insurance - Call Centre Representative
March 2008 - May 2008
Telecast Marketing - Client Representative
February 2006 - January 2008
Zilberstein Zippers - Administrative Assistant
February 2005 - November 2005
Tranquil Telecommunications, Inc. - Client Representative
September 2004 - December 2004
CWN Papers Ltd. - Account Representative
May 2004 - August 2004
Erica's education includes a Master of English in Concentrating on Literary History and Identity Politics (1998-2000), as well as a Bachelor of Arts in English Literature (1994-1998).
Erica's address is:
1031 Palmerston Ave.
Toronto ON, M6G 3A7
Her license plate reads "A3R 3E5".
Erica was fired from her job as a customer service salesperson from WCP Insurance for being 'too smart'.
Erica is allergic to nuts, which is shown in the cafe when she drinks the hazlenut mocha mint latte that the clerk gives her and has an allergic reaction to the contents and she ends up in the emergency room.
Quotes Dr. Tom uses in this episode:
Pressure makes diamonds. - General George S. Patton
In the middle of difficulty lies opportunity. - Albert Einstein
Do not weep; do not wax indignant. Understand. - Baruch Spinoza
The life which is unexamined is not worth living. - Plato (paraphrased)
We learn to do something by doing it. There is no other way. - John Halt
Curiosity does, no less than devotion, pilgrims make. - Abraham Cowley
There is a crack in everything, that's how the light gets in. - Leonard Cohen
The most exhausting thing in life is being insincere. - Anne Morrow Lindbergh
No party is fun, unless seasoned with folly. - Desiderius Erasmus (paraphrased)
It takes a lot of courage to grow up and be who you really are. - EE Cummings (paraphrased)
Those that fail to learn from the past are doomed to repeat it. - Winston Churchill (paraphrased)
If life's journey be endless, where is its goal? The answer is, it is everywhere. - Rabindranath Tagore
Your parents will mess you up. They don't mean to, but they do it anyway. - Philip Larkin (paraphrased)
Learn to be what you are, and learn to resign with good grace all that you are not. - Henry Frederick Emile (paraphrased)
Featured Music:
"Tricks Are For Kids" by Lauren Evans (Trevor calls Erica)
"It's A Lovely Day Today" by Stacey Kent (Erica flees from the rain)
"Where Does The Good Go" by Tegan and Sara (Erica looks at her pictures)
"Yesterday Man" by Roz Bell (Sung by the street musician)
"Tainted Love" by Neverending White Lights (Flashback to the Fall Dance)
"There She Goes" by LA's (Erica goes back in time)
"My Old School" by Steely Dan (Erica meets her dad)
"Roam" by The B52's (Erica picks her clothes)
"Right Here Right Now" by Jesus Jones (Erica talks to Noah)
"Wishing Well" by Terence Trent D'Arby (Samantha gets ready)
"It Must Have Been Love" by Roxette (Erica makes out with Noah)
"Tainted Love" by Neverending White Lights (At the Fall Dance)
"Free Your Mind" by En Vogue (At the Fall Dance)
"Can't Touch This" by MC Hammer (At the Fall Dance)
"More Than Words" by Extreme (The ambulance takes Katie)
"Where Does The Good Go" by Tegan and Sara (Erica meets Judith)
Erica's locker combination is 12-33-24.
Dr. Tom's address is
47 Sugar Street
Toronto, ON
(416) 555 - 0117
flashbacks, light science fiction, love/hate relationships, infidelity, divorce


text: Can anyone recommend a "food tour guide" for Queens or outer Brooklyn? My husband and I are interested in checking out some of the more gringo-free establishments in each of these boroughs and thought that probably the best way to do it is to go with someone in the know. I don't think we are looking for a large group tour, but rather a one-on-one type experience. Any suggestions? Thanks!


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Use the form on the right to contact us.
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Unit 7 Bridge Court 12 Cook Street
ScheduleScheduleBeautiful natural floristry inspired by the Scottish landscape for weddings, events, gifts and home. Glasgow based covering Scotland
Sold in wraps of 50
With the sweetest of scent Freesia are delicate and dainty blooms to incorporate in bridal bouquets and are a great choice for ladies corsages.
Availability (guide only)
All year
Care - Pinch off spent blossoms to encourage the other blossoms to open and make the flowers last longer


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iPhone stocked – red charging sign and this was how I fixed it
iPhone 5 was out of action for several days. So, we visited the Apple repair center in Promenade Mall here in Springs the other day. I just waited inside the truck because I just want to fetch them at the entrance of the store when they're done. When I saw them get out (after several minutes), I drove and get near the entrance because they didn't know where I parked. I didn't also know if they saw the vehicle and I didn't want them to walk far because it's cold that day. When they're seated, I asked if it's fixed but my husband said not, and they just offered to upgrade/change cellphone because they cannot diagnose the phone as it won't switch on. So, I told my husband, I will fix it myself, and I know it will switch on again just like my old iPhone 4s. Continue reading
Movavi 15, Cyberlink Director 15 and Movavi 17 Review
So far I've tested three video editors – Movavi 15, Movavi 17, and Cyberlink Power Director 15.
I had fun using Movavi 15 as it's an easy to use video editor. It's just that I need more, like the callout features and other artistic stuffs. Also, when saving my projects, it will take me several minutes to finish depending on my video choices – good, high, or highest quality.
So, I tried buying a new one the Power Director 15 because it's on sale. The software offers lots of amazing features, but I've got to play with it more to enjoy everything that it offers. It is a bit complicated compared to Movavi 15. The thing that I love most with Power Director software is that there are lots of templates and themes to use. There are many things to download from Cyberlink website as well. And the best thing is that when I will save my projects, it won't take long and it's done. It is a 64bit software, and so it is fast. It is also fast uploading in my youtube channel.
I do love Movavi 15 and the simplicity of the software so I've decided to buy the Movavi 17. When I tried it, I was amazed because it offers additional features like the callout or speech bubbles and some artistic things. But it is the same, it takes time in saving my projects, and it will also take time in uploading it.
I do love the two software – Movavi and Power Director. There are times that I will edit my video first using Movavi and then transfer my saved projects in Power Director to give more art to it.
I just love video editing, and I want to be consistent in posting vlogs on my channel.
#Lightdow LD4000 1080P #HD #SportsActionCamera Bundle
I bought this #Lightdow LD4000 1080P #HD #SportsActionCamera Bundle with DSP:NT96650 Chip, 1.5-Inch LPS-TFT LCD, 170° Wide Angle Lens and Bonus Battery as a gift for my daughter. I also bought a blue one for my son. They love to take videos and with this, they can do it anytime they want. With these #sportsactioncamera, they will not be begging to borrow some cellphone for the videos that they are going to make.
I love these #actioncamera coz it's small and it will just fit in the palm. It will take good movies and good photos but it will depend on the person that's using it. With this video, it's my daughter and my son who's testing it when they visited the park yesterday. And they're having fun.
Anyway, these cameras are so affordable and within my budget. I am so glad my kids love these.
Fixed my problem about "Welcome to Verizon Wireless, there was an error in processing" your call
Okay! I have a new phone, alright as per my last post as it's a recent gift from my husband! But I am having a hard time connecting to the network. It says that error in processing calls and it will connect to Verizon when my new line is not Verizon anymore. I tried everything already, to the point of draining the battery of my phone (resetting to factory default many times). I tried calling my new network over and over again but then they'll just keep on test calling my phone with their 800 number and asking me to switch on and off. The last time I talked to the CS, the guy said that I need to call Verizon and ask them to help me fix my phone. You know I have lots of things in mind (maybe my phone is being locked or something). I tried calling Verizon but then the CS guy who answered me transferred my call back to my new network. So, I just put down the phone coz I know it won't help. Then, I kept on searching online on what to do. I tried everything already from dialing different numbers with asterisk and pound signs but it won't work. So, I thought of calling #8899 again and the CS woman who answered me told me to call my new network and ask them to do a new reactivation coz when the phone is unlocked it won't be under Verizon's system. I thought of calling them again but I know they cannot fix it. Then, I remembered that with this 2nd phone number that I have had since last year if I remembered it right, Verizon kept on calling me about billing issues. I thought, maybe it's time for me to change my phone number and I'll see if this new phone number with my new phone will work properly. I dialed the toll free number of my new phone company and followed the instruction and then waited for more than five minutes to make sure that I will have a new phone number reflected in my gadget. When I've seen a new number, I tried dialing it and the call get through my phone. I also tried calling the phone of my husband and it work well. And now everything is a-okay. I hope this new number and new phone will work great together coz I love the phone especially that it's 64GB (how I wish it's 128GB haha). Oh well, this is a gift heartily given to me and so I am happy for this (to think that 64GB is big already). Now I've got to text and inform my friends of this new number that I have so that they can text or call me whenever they need/want.
Anyway, if all else fail with your iPhone, like you cannot make calls and you cannot receive calls, maybe there's something wrong with the present number that you have. Might as well change it or ask your present cellular phone carrier to reactivate your phone. Who know this will work coz mine is working right now. I hope your phone is working at your end as well!
A mother's day gift
I said to myself that I am not high tech person anymore. I can go with just simple phones and I can even go out without having a phone. But then my husband gave me this iPhone 6 as a mother's day gift this year. I am grateful to have this as I can do lots of things with my new phone. Even if this is a prepaid but then it is still functioning like it's postpaid with less money if I am using this in minimal ways. To my husband, thank you for giving me this phone. Love you!
So happy old iPhone is working again
I was sad. I thought I'd lost my iPhone since it won't charge complete. I charged it last night but when I woke up this morning, it's just had a red bar. I was sad then. I even unplugged it. When I got back to it after I cooked for breakfast, it was having a 60% battery and I was wondering why it has that plenty of battery when I unplugged it. Right now, I am trying to get all of my photos because that's the most important things that I need. Hope my old iPhone will still serve me longer! I love this one because this is 64GB. If there will be another phone replacement, I want that it will be the same 64GB or it will be 128GB! Oh bother – who can give me another phone?
#positivevibes #positiveqoutes #love #life
Business Optimization 101: Your Quick Reference Guide To Success
If you run a company and want it to be as successful as possible, you should begin thinking strategically immediately. Accessing and implementing proven expansion strategies is a wonderful way to keep your company on the road to perpetual growth and an ever-increasing sphere of authority. Below you will find just three of many business optimization techniques you can use to get the expansion process underway right now:
1. Utilize Consulting Services.
Business owners who are serious about optimizing their daily operations should invest in consulting services. Business consultants will typically be able to implement a customized, cutting edge strategic plan that helps enhance each individual component of your company. This includes anything and everything from your leadership capacities to employee development. Organizations such as KeyGroup Consulting provide clients with multiple growth strategies, including guidance for managing a multi-generational workplace.
2. Build Your Brand Online.
Another strategy you can implement to optimize conversion and increase your company's sphere of authority is building your brand online. This strategy will empower you to share your products and services with people across the world, thereby increasing the likelihood that your company will become global in scope. The simplest way to build your brand online quickly and correctly is by hiring a group of experienced digital marketers. These individuals will typically be able to utilize multiple marketing methodologies to get your company going and growing in the Internet realm. Some of the growth strategies implemented may include:
-social media optimization
-web design and development
-link building
-online reputation management
-keyword analysis
-responsive web design
-target market research
3. Create SMART Goals.
One final business optimization strategy you should definitely employ is the creation of SMART goals. Research shows that individuals who write their goals down are more likely to realize them. As you begin the process of defining and writing down your objectives, make sure that they are SMART: Specific, Measurable, Attainable, Realistic, and Time-specific. An example of a good SMART goal would be: "We will remain open for 2 extra hours on Friday and Saturday during the summer months (June, July, and August) to increase revenue by 23%."
If you're serious about business optimization in 2016, know that operating in an orderly, systematic way can help you realize your professional vision. By consistently implementing the simple strategies outlined for you above, you'll likely find that your company begins to grow and expand in a powerful way.
Freebies with Shopkick
I've been a member of shopkick – http://get.shopkick.com/oakland67062 for more than a year now. I already claimed my first reward last year and I gave it to my friend but she didn't use it yet. Then, I deleted my app from my phone.
This year, I thought about it and try to use it whenever I can remember it every time I will shop. Besides, clicking the app is free and I can earn points. With the accumulated points, I can claim some e-cards and I can redeemed it whenever I want.
Last week, I tried to use it at one of the grocery stores here in my town. I just want to earn walk-in kick points (upon entering the store) and then I can also earn points when I will scan some items that shopkick put in their apps. When I entered the store, shopkick won't let me do it. It stated that I should go to the entrance for the shopkick points as a proof that I am within the store. So, I went back at the store entrance and tried to open the app but it didn't let me. Since I wasn't able to have the WALK-IN KICK POINTS, therefore I cannot scan the products that they want me to scan. It didn't matter though, I can try it next time.
Anyway, whenever I am not using this app, I will have to moderate on the access of this app in my phone for privacy. I'll just have to open it whenever I am in the store that they are affiliated with for me to earn walk-in kick points and some scan kick points.
On the other hand, I've learned this app through my friend (thanks to her) and it's fun for as long as the app will give me a walk-in kick points and I can use the app to scan some items for me to earn kick points. Freebies are always great to have!
Drone or UAV (Unmanned Aerial Vehicle)
I am a tech person and I love everything about it. One of the new technologies that fascinates me these days is drone or UAV (Unmanned Aerial Vehicle). The one that I like is small in size and fits my hands but with the features that I love. Like it can be stealth, high resolution camera and video, with GPS, and the one that has a 'return home feature'. Although, I am wishing that there is a drone with the colors of mustard yellow, sky blue, pink, and or green. I just love these colors.
Do you love drones as well? How many drones you have in your collections?
Parental control for Android Devices
People these days are into high technologies and gadgets that include toddlers, kids and teens. Way back when I was a kid, my toys were different and I was contented with few things. But these days, kids are way different. They are into these high technology eras wherein they have lots of things to learn from the internet. But not only that, when they can learn good stuff from any website online, they are also vulnerable with bad stuff. That is the scary part. Scary in the sense that, kids are easily influenced when they will not choose the things that they will watch, read, and play online. Yes, internet is very influential not just locally but all over the world. Anyone can just spread either love or hate. There are lots of websites, apps, and just anything online that can easily caught kids' attentions.
Now, are you weary that your kids can easily be influenced with what they are into online through their Android devices? If that is what you are feeling, then you need to check on How to Block Apps on Android Devices.
Yes, kids might be at home and it seems they are safe. Yes, they are safe as you can see them and they are away from any physical harm but what about online? Are they safe enough to just browse around with anything that they like? There are many ways to guard kids and teens from just doing anything online. One of these ways is to have a good Parental Controls for Android. Having these can help you have a peace of mind that your children cannot do any unwise things over the internet. Another thing is that you need to control their online time and their gadget time. If it is not healthy for them to just browse anything, it is not also healthy for them to browse the whole day and whole night. There should be time limit along with the limits on the apps that they are allowed to use.
Safeguarding your kids from all of the harmful online stuff is like guiding them on where to go in life. It is like preventing them to not roam around anywhere outside the house and helping them not to get harm from any bad influences. Online parental control for any android devices is saving your kids and protecting them from the disadvantages of the high technology world.


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Here are the latest events and happenings for the Sunset Rotary club. Feel free to just in and help if you have the time available, we love company when we are helping change the world one event at a time.
Enjoy a bag lunch courtesy of the Sunset Rotary Club.
June 2017:
2) 3rd – AUSA / Sunset Rotary Tour De Campbell Century Bike Ride
5th – Rotary Leadership Institute (RLI)
8th – Joint Rotary Christmas Party – Members and Family only
June 2017:
Rotary International Annual Convention, Atlanta, GA
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Includes two hygienically superior silicone interchangeable sleeves (single node sleeve and quad node sleeve) and flexible air hose for adjustable suction. Clitoral pumps increase blood flow and create a whole new sexual sensation. Although the vibration is not adjustable, the amount of suction and intensity of vibration can be increased through the circular movement of the pump. Great for nipples too!
The First female online intimate shop catering for Nigerian women has arrived. We are so excited for this opportunity to serve our community.
Our aim is to offer the best selection of sexual health products and erotica sourced from around the world that enhance the sexual expression and sexuality of women in intimate relationships.
We treat all women's sexuality as equal: regardless of your sexual preference, whether in your 20's, 30's, 40's, 50's, 60's, 70's or 80's, a mother, disabled, a survivor of cancer, like to swing from chandeliers or prefer the missionary position you will always be welcome at Intimate Pleasures Desires of the Heart.


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Attitude and A Fistful of Credsticks both available in print!
Your order has been received, however any item ordered between May 18th and June 1st will not be processed until our shippers return to work following their move to a bigger warehouse. I understand this information is posted on our website.Processing will begin on June 2nd, 2015. Your items should complete processing at that time and ship accordingly within the days following June 2nd.Best regardsDawn