text:
Azerbaijan, Russia Hold Consultations On Caspian Sea Status
Azerbaijan and Russia agree that the Convention on the Caspian Sea status, the adoption of which is expected by the Caspian littoral states, should ensure the sovereign rights of each of the five littoral states and meet their interests.
This was announced during the Azerbaijani-Russian consultations on the legal status of the Caspian Sea, which took place in Moscow on April 10, the Azerbaijani Embassy in Russia told Trend.
The consultations were chaired by Deputy Foreign Minister of Azerbaijan Khalaf Khalafov and Special Envoy of the Russian President, Ambassador-at-Large Igor Bratchikov.
The sides exchanged views on the implementation of the agreements reached during the Baku meeting of the special working group of the Caspian countries on the status of the sea held on February 25-26, and then continued discussions on open issues.
Determining the legal status of the Caspian Sea has become one of the problematic issues among the five littoral states – Azerbaijan, Russia, Iran, Kazakhstan and Turkmenistan since demise of the Soviet Union.
The legal status have been remained unsolved during the past two decades, preventing development and exploitation of its disputable oil and gas fields and creating obstacles to the realization of major energy projects.
The Caspian littoral states signed a Framework Convention for the Protection of the Marine Environment of the Caspian Sea in November 2003.
Russia and Kazakhstan signed an agreement on the delimitation of the northern part of the Caspian Sea in order to exercise sovereign rights for subsoil use in July 1998. The two countries signed a protocol to the agreement in May 2002.
Moreover, Kazakhstan and Azerbaijan signed an agreement on the delimitation of the Caspian Sea and a protocol to it in November 2001, and February 2003, respectively.
Kazakhstan, Azerbaijan and Russia signed an agreement on the delimitation of adjacent sections of the Caspian Sea on May 14, 2003.
By Amina Nazarli,
Amina Nazarli is AzerNews' staff journalist


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Meridian Products, LLC was founded in 1999, originally as a maker of wire products. Soon we expanded into tubular, steel products and became very successful at meeting the needs of original equipment manufacturers.
Today, we manufacture and distribute stainless steel and aluminum hardware that are both remarkably decorative and absolutely functional. We form and finish decorative metal trim pieces for a variety of industry sectors, including bathroom, commercial kitchen, residential kitchen, automotive and marine.
We are an established, global manufacturer, leveraging lean and flexible technologies and processes. We are ISO 9001:2008 certified and a leading producer of metal roll forms, aluminum extrusions, die cast aluminum and zinc components and coated wire products.
We are based in Kansas City, Missouri USA, and are centrally located in North America. We are a woman-owned business offering solutions to original equipment manufacturers of many types, and located throughout the globe. Our ISO 9001:2008 certified production facilities are located in Asia, allowing us to offer cost-effective solutions to our customers.
Contact us to learn how we can put our experience to work for you.

subset: commoncrawl


text:
|Professional Automotive Repair Technical Discussions for June 23, 2010
International Automotive Technicians' Network (iATN) - Members Only
|(Also Available: All, Asian, Chrysler, European, Ford, GM.)
|Vehicle Owners: If you are seeking an automotive repair professional to service your vehicle, visit the iATN Repair Shop Finder.
Open Help Requests for Ford
|Help Request
|1993 Ford Bronco XL 5.8L reverse VIN: 1FMEU15N4P
automatic transmission experts, please help! this is my dad's vehicle. i just finished overhauling this e4od, and now there is no reverse. when i place the selector in the reverse position, the rpm raises about 200-300 rpm. here's the history of the vehicle: ...
|1996 Ford Contour SE 2.5L No Start VIN: 3FALP67L4T
I think ive heard about this before but cant remember solution . Car cranks fine , will not start under any conditions unless ether is sprayed into throttle body area .once running you can drive the car all day long .that o2 sensor cant make a no start , can i... Trouble codes: P0151, P0430, P1151 (Ho2s21 sensor indicates lean)
|1997 Ford F-350 XLT 7.3L Erratic O/D Shifts VIN: 1FDKF38F9V
Hey folks! I'm looking for some help on this F350 Diesel pick up. The truck has erratic O/D engagement and disengagement. I've driven the truck on several different occasions and the problem is there every time. When you take off from a stop the tranmission sh...
|1998 Ford Windstar 3.0L 3.0L No Start VIN: 2FTDA54U0W
Good morning techs. This one has me pulling my hair out! Vehicle came in back in January with no start. Has spark but no fuel pressure, ched wires at the tank, all circuits good. Replaced fuel pump. Vehicle running fine until this week. Custome called and saii...
|1999 Ford E-250 Econoline 5.4L Poor Idle Quality, MIL Lamp on VIN: 1FTPE24L3X
Hello everyone, I have poor Econoline Van that's kinda kicking my butt. The Problem it that I has a poor idle and will set a lean code on bank 1,+ 25% and drops off idle. I have smoke tested and leak tested the intake till I was blue in the face. The only bad ... Trouble codes: P0171 (Lean Bank 1)
|2001 Ford Mustang 3.8L High idle VIN: 1FAFP40421
Good morning i have a mustang that when the clutch is pushed in the idle tends to stay where ever it is when the clutch is depressed. Will eventually come down but takes an excessivly long time. Idle is normal when started and sitting still. Example, pull up t...
|2002 Ford Windstar SE 3.8L Surge, Cuts out, Misfire VIN: 2FMZA51402
I am not a ford man... at all... I am stuck on this one with a missfire complaint on acceleration in town driving and at highway speeds.. . I have no way of knowing where to begin- first of all i dont know if it is missing due to ignition or fuel.. I have trie...
|2006 Ford Escape XLS 2.3L Misfire, MIL Lamp on VIN: 1FMYU03106
the misfire on this escape is very intermittent- it may go 1-2 weeks between episodes and run perfect when not misfiring. the first time this came in we pulled the codes and found that cylinder #2 was under the plenum, making it difficult to inspect the plug o... Trouble codes: P0316, P0302
|2003 Lincoln Town Car Signature 4.6L Radiator Cooling Fan VIN: 1LNHM82W63
Hi I have this car that came in with a broken fan blade on the electric cooling fan. I replaced the entire fan assembly with a new one. But when I ran the car the fan runs on slow speed and the speed constantly goes up and down and never stays on high even whe...
|1998 Mercury Grand Marquis GS 4.6L coolant temp sensor VIN: 2MEFM74W3W
vehicle came in for overheating, cel on. pulled 2 codes -p1285, p1299- that confirmed the overheating. found 3 problems - fans don't operating, temp gauge reads inaccurately, and coolant temp sensor reads -40. alldata isn't very clear on whether the cylinder h...
|2000 Mercury Sable LS 3.0L Cuts out VIN: 1MEFM59S6Y
This car came in to us for a cutting out problem. Customer said while he stopped at a lite that the car cut out he left it on the side for about two hours and later on he drove it in to us without a driving problem. After i scanned the car i found code p0191 (... Trouble codes: P0191 (Fuel rail pressure range)
Fixes & Summaries for Ford
|1996 Ford F-250 XLT 7.3L TCC Lock-up VIN: 1FTHX26F6T
I got 4 help offers. There were suggestions to monitor pin 28, the tcc wire, for ground . Test tps, vss, map, mlp and codes. I was using a break out box, scanner, scope and DVOM to test this truck. I didn't see anything out of range and was going to test every...
|1998 Ford F-150 XLT 4.6L a/c VIN: 1FTZF17W8W
this goes out to all that said the blend door was broken. I have put many of these in alot of different Ford trucks but I havent ever had one rehome each time the a/c mode switch was turned off. thats what sent me for the loop. Filing this one back in the ment...
|1999 Ford Windstar 3.8L dies VIN: 2FMZA5145X
We checked the fuel pump relay and put a new fuel pump and fuel filter in it and have not had any problems with it since. Soory for the delay, problem was so intermited we wanted to make sure it was fixed before closing. thanks to all who responded.
|2000 Ford Ranger XL 3.0L Mechanical VIN: 1FTYRI4V7Y
Hello Everyone, I would like to say "THANK YOU" for all the excellent replys I got for this troublesome Ranger. Well it ended up being the "FORWARD SPRAG" as alot of you guys had mentioned. I really do not know how I missed this but I guess when you run a one...
|2001 Ford F-150 Lariat 5.4L cooling VIN: 1FTRW07L61
I decided to put an accumulator in and evacuate and recharge the system. That worked. Thanks for the help. The help I received help me understand that since the pressures were OK for an almost 100 degree day, contamination of the refrigerant must be the pro...
|2001 Ford F-150 XL 4.2L MIL Lamp on VIN: 1FTZX17271
thank you for your ideas, 3 replies recommend new isolator bolts for the plenum, we did locate a vacuum leak at the rear-right side of the lower intake manifold. with the car up on the hoist engine running, we can use carb spray and the short term fuel trim wo... Trouble codes: P0171.
|2001 Ford Ranger XL 3.0L lack of power VIN: 1FTYR14U71
Thanks to Jason [...]. He said he had a similar problem, that turned out to be the cam sychronizer and sensor. In the beginning I actually asked my Ford parts counterman what he thought, and he suggested the cam and syncronizer also, but I have changed many ...
|2001 Ford Mustang 3.8L differential VIN: 1FAFP44471
After reading Bradley's reply and feeling like a mental midget, I remeasured the pinion depth and back lash and they were good. I then did a tooth track pattern and found a really abnormal track pattern. I have never had a gear make noise intermittently, but i...
|2002 Ford F-150 XL 4.2L MIL Lamp on VIN: 1FTRF172X2
THANKS TO ALL THAT RESPONDED FOR YOUR HELP, HAVE REPLACED GROMMETS IN INTAKE AND FUEL TRIMS SHOW VERY LITTLE ADDED FUEL AT IDLE AND 2000 RPMS. I RESET KAM AND CLEARED CODES, BUT THE OWNER IS OUT OF TOWN AND I DONT KNOW IF THE SES LIGHT HAS COME BACK ON. Trouble codes: P0171 (Engine lean bank 1).
|2006 Ford E-350 Super Duty XLT 5.4L Abs Module VIN: 1FBSS31L26
After 2 diff abs module and a reprogram of ecm the abs light remains on. We completed all pinpoint test and it points to I/C The customer has not yet brought vehicle back and is not sure if the want to try used or rebuilt cluster.


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We are born kind, loving, generous, and wise – Anything is Possible.
Unconditional love and listening are two of the most important ingredients that help children grow into kind, successful grown ups who are able to create a life they desire. But generational beliefs and painful experiences mean that some of us didn't receive the love and listening we needed from the adults in our lives when we were little. If that's the case for you, then you may get overly frustrated or down on yourself. This may interfere with your life. Your parenting goals of providing the love and attention your children need may take a back seat to the overwhelm you feel at any given moment.
Your childhood might have left you with deep down hurts – some that you are aware of and some that you are not. These hurts can affect you and/or interfere with the life you want. It can thwart how the love and listening your want to provide for your children. Stress, old hurts, pain and stuck-ness can block you from being your best for yourself and your kids.
I grew up in a house with 8 people: 2 were parents and the other 5 were my siblings. Being a highly sensitive person and number 5 of 6 kids – with parents who were barely making ends meet and who were carrying their own childhood traumas – made for a very stressful childhood. The things I observed and endured were not life threatening, but they hurt just the same. These experiences also created in me a deep longing to help others which began to manifest in me by the time I was 5 years old. My journey is filled with a successful search for learning, healing, and transformation. I'm so pleased to share and be able to support others like you who are on a similar healing journey.
Stresses, traumas, and hurts we've experienced can sort of 'stunt our growth'. The good news is that we can release pain and return to healthy growth. I think of this as Growing Up Kind and its meant for people of any age.
I'm here to help you release old hurts and transform your pain with compassion and kindness so you can live a life of joy and model for your kids that anything is possible.
I'm passionate about helping children age 9 to 99 Grow Up Kind. I offer tools that create deep healing and help you return to the feelings of aliveness, joy, and the all encompassing possibility that is available to each one of us. You may not remember ever feeling this way, but all things really are possible and I'd love to help you experience this!
I'm a certified Life Coach with over 20 years of experience working with individuals and corporations. I specialize in Somatic Coaching and Somatic Experiencing. I offer fun and engaging classes and books. On my Blog you'll find free videos and tips that will help you right away. Start Here to find complimentary meditations, videos, tips, and classes that I created just for you!
I'd love to meet you and answer your questions in the Growing Up Kind™ community.
Questions? Please reach out, say hi and let me know how I can help!
Wishing you love, magic, and kindness,
A little more about me and my family, too.
I teach regularly at Elizabeth House in Pasadena, California. Elizabeth House is a maternity shelter that supports women and their children and helps them get back on their feet. I also teach young moms and dads at Learning Works in Pasadena, a continuing education high school for kids who once dropped out. I'm available to speak or teach at your venue or event. Contact me to learn more.
My husband and my son are kind, supportive, and funny. I am so blessed to share my life with them. My favorite thing to do is spend time with my humans and my doggies.
Giving back is second nature. I've volunteered in many other ways over the years. Any place that reminds me of home is my favorite place to be! Fortunately for me, Paris feels like home and so does nature and kind friends. I'm creative, kind, and intuitive. I love sharing what I've learned – so much so that my friends call me Sharasaurus!
If you've made it this far, thank you for reading! Here's a photo of my doggies. They are my furry babies and they create all kinds of happiness in our house.
I hope you've found something here on my site that will support you and your kids in feeling better so you can do better!
With love and magic,
P.S. Meet one of our furry babies posing as "Princess Dobby" the "Life Coach"! FYI: her real name is Piggy and she is an amazing resource for me and my clients, but she is definitely not a life coach!


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Its Thursday! Time to live in the past! Yesterday I was thinking about some of the bands that I used to listen to as a kid, and it gave me the idea for this post. Here is a list (in no set order) of some of the
awesome music artists/bands I listened to as a kid. I seriously had great taste.
1. Brandy,I loved Brandy as a kid, the album pictured is pretty much the only one I listened to. But I played that album OUT. I remember using a portable cd player and this was one of the albums I always had with me when I went to Summer Camp. haha.
2. The SPICE Girls! Need I say any more than that? This was the first group or artist that I completely fell in love with. Ever. Its the first album my parents ever bought me, and I remember locking myself in my room and singing my heart out to every single song. Girl Power.
3. Usher, I loved this dude all the way up to Confessions. Then our love dwindled, but I still go back and listen to "My Way" every now and then. It was another one of those albums when I was younger that I could never get enough of. This is an artist that I was still in love with in my teens, but thats a different post for a different day.
4. Britney Spears, I mean, who didn't like her as a kid? I just remember watching all of her music videos and wishing so hard that I could be her! I also remember singing her songs in talent shows with a few of my friend, and just loving her. So much.
5. B2K. Can you say "drool". My first huge boy band crush! I CRIED when they broke up. I remember, my mom was driving me to school, and I heard it on the radio..worst day ever. I own every album still, and back then this was pretty much all I listened to at one point. Pure fan girl obsession. Here is my absolute favorite song and video from them. This is the video that started the strongest love I have ever felt for boys I didn't even know.
Ok, let me stop drooling here and move on…
6. Destiney's Child. "Bills Bill Bills", "Say My Name", "Bootylicious". The list goes on, I loved everything they put out, from the very beginning. Everything. They pretty much filled my heart after the spice girls broke up and left it broken and empty. =[ I love Destiney's Child.
7. Lil' Bow Wow, I am pretty sure he was the first "rapper" I listened to. I mean obviously, I listened to other rappers on the radio but I mean, this was probably the first "rap album" I ever bought. haha. I was absolutely in love with this guy. I mean between him and B2K, I had a lot of obsessing on my hands. I actually got to see him in person, I made a vow after buying his first album that I would buy every album he ever put out, and I kept that vow until about two albums ago. Seriously, I thought we would actually end up married one day…I mean I seriously thought that.
8. N'Sync, I loved N'Sync. I wasn't in love with them like most girls, I actually just really liked their music, and I preferred N'Sync over the backstreet boys. I know, it was a whole thing. Anyway, I did have a crush on one member, and no it was NOT Justin, I had a crush on Lance. So you can imagine my disappointment when I found out that he plays for the other team. But regardless, I thought they were pretty freakin awesome back then!
9. 3LW. Does anyone else even know who this group is? If you ever watched the Cheetah Girls then you will recognize two of the members of this group. This is probably the most embarrassing group on this list. haha. A friend of mine introduced me to them, and I am pretty sure I only liked one of their albums, but we listened to it all. the. time.
And thats it! There were, of course, many other artists that I listened to back then, but these 9 stuck out in my mind a lot more than any one else. These are albums I purchased and listened to over and over again!
What music did you listen to a a kid, are there any that make you shake your head in embarrassment?


text: Acqua Condominium is a resort-style condominium which has an elegant and modern design. The project features two 8-storey buildings with a total of 309 units. All units are designed to be efficient and fully functional. Apartments range from studios to 2 bedroom units. The condo is easily accessible from Jomtien Beach Road, Jomtien 2nd Road, and Soi Wat Boon just off of Sukhumvit Road. Acqua Condominium is equipped with modern facilities including 50 meter swimming pool, 2 rooftop pools and a kid's pool, BBQ area, yoga room, fitness and sauna, plus much more.


text:
SANTA MONICA, Calif.--(EON: Enhanced Online News)--Popular pet site Cuteness.com (Cuteness) today announced the launch of "The Cuteness Pawdcast," a weekly podcast for pet-lovers. The show will cover topics such as pet tech, health and training tips, trending pet and animal news, and interviews with celebrity pet owners. The podcast is co-hosted by comedians and pet lovers Allegra Ringo and Renee Colvert.
"Cuteness' new podcast is a natural extension for the brand"
Cuteness, the #3 pet site per comScore*, is a destination for health, training, and behavior tips—as well as cute, funny, and inspiring pet stories from around the world. Cuteness has an audience of over 3M unique visitors every month and a loyal social media community of over 900K followers across Facebook and Instagram.
"Cuteness' new podcast is a natural extension for the brand," said Mitchell Pavao, Senior Vice President of Media for Leaf Group. "The hosts' comedic take on informative and trending pet-related topics bring the best of Cuteness to life, and will introduce the brand to new, pet-loving audiences."
Allegra Ringo is a writer and dog lover who has contributed to VICE, Reductress, and the Hairpin among many other publications. Renee Colvert is a writer and comedian who has performed stand-up at The Improv, The Laugh Factory, and The Comedy Store. Both co-hosts are also contributors to Cuteness.
New episodes of "The Cuteness Pawdcast" will be released every Friday and are available on iTunes and Google Play. Episodes are also available online at www.cuteness.com/podcast.
About Cuteness:
Cuteness is the #3 pets site (via ComScore, among ad-supported sites), featuring viral animal videos, educational articles, pet-friendly DIY projects, and health and training tips. With its daily editorial content and active social media community, Cuteness is the go-to hub for animal lovers to discover pet-themed inspiration and content.
For more information, visit www.cuteness.com and engage with us on Facebook, Twitter, Pinterest and Instagram.
* Rankings based on March 2017 comScore among ad-supported sites


text:
Kona Submarine Tour and Resort Luau
Book the ultimate day of fun for the whole family on Kona Island. Your journey will begin with a beautiful exploration of the life under the sea and finish off with a traditional Hawaiian luau.
Kona Island Submarine Tour
See the beauty of the sea life surrounding Kona aboard an Atlantis submarine. Our 48-passenger vessel will take you and your family to see a new view of the vibrant ocean world surrounding Hawaii. This part of your exciting adventure is a perfect Kona activity for kids to start your day off right.
Kona Resort Luau
After you have enjoyed the wonders of underwater travel through Atlantis Submarines, your adventure continues with a traditional Hawaiian luau at the Kona Resort. Be prepared to enjoy local dancers and musical performers to make your trip to Hawaii fun for the whole family.
The Lava Legend and Legacies Luau & Revue at Kona Resort is a fun evening of musicians and dancers who will take you and your family through a fast-paced journey of the South Pacific Islands. The evening includes an island-style feast and an unforgettable Samoan 'fire knife' dance performed by Kona locals.
Atlantis Submarines | Kona
Atlantis Submarines | Kona
Address: 75-5669 Ali'i Dr, Kailua-Kona, HI 96740
Phone: 1-800-381-0237 or 808-326-7939
Hours: Open daily 9AM-4PM


text:
Are you in the dark about what your board of directors is supposed to do?

You're not alone. Board responsibilities are often poorly understood and badly communicated.

Board member duties fall into two camps: legal responsibilities and "should do" duties.

Legal Responsibilities of the Board of Directors

A nonprofit incorporates in the state where it is headquartered. For charitable nonprofits, incorporation usually precedes filing for tax-exempt status from the IRS.

Many states have laws governing the functions of the board of directors of nonprofits and the conduct of board members.

A nonprofit board must oversee the nonprofit organization's operations and make sure that its staff and volunteers act legally and ethically. States often use the following principles of nonprofit corporation law.

Duty of Care:

A board member must be active in organizational planning and decision making. Board members must exercise reasonable care when he or she makes a decision for the organization.

Reasonable care is what an "ordinarily prudent" person in a similar situation would do.

Duty of Loyalty:

A board member must never use information gained through his/her position for personal gain and must always act in the best interests of the organization. Board members must avoid conflicts of interest or the appearance of conflicts.

Duty of Obedience:

A board member must be faithful to the organization's mission. He or she cannot act in a way that is inconsistent with the organization's goals. The public trusts the board to manage donated funds to fulfill the organization's mission.

Also, your board must:

Make sure that the organization follows the law.

Approve all key contracts.

Attend most board meetings, thus indicating a dedication to the organization.

Hire and supervise the executive director.

Make sure the organization remains financially solvent by evaluating financial policies, approving budgets, and reviewing financial reports.

Make Sure Your Board Members Understand and Commit to Their Duties

Since a nonprofit belongs to the public and serves the public interest, the board of directors has been given the responsibility for making sure that the organization abides by the law.

Make sure that your board members realize the seriousness of their duties when they agree to serve on the board.

To ensure that a potential board member understands his responsibilities the CEO and board president should have a sit-down meeting with the new board member.

Such a meeting will likely impress the new board member or potential member with the seriousness of their board commitment. An overview of board responsibilities is especially important for new members who haven't served on any other boards and for members recruited from your volunteers.

While volunteers bring an in-depth knowledge of how the organization works, they may not understand what a board does or realize that they must help with fundraising.

After that initial meeting, the next step is training. If you have several new board members, a group training works well. Board members can learn about the organization's history, mission, bylaws, activities, and more.

Include a tour of your facility, introductions to key staff, and some time devoted to observing your programs in action. Arm new board members with lots of reading that they can do on their own.

Don't assume that new board members understand:

 What a nonprofit is,

 how it is different from a for-profit,

the role of staff versus board,

 potential conflicts of interest,

or how nonprofits get their revenue

Match Board Members to Your Organization's Needs

Your board can be a wonderful source of pro bono expertise in areas that you need to understand but can't afford professional help. For instance, your board members could have skills in:

finance

public relations

legal and human resources or programmatic areas such as social services, education, religion, etc.

Put Fundraising Front and Center

So many nonprofits are reluctant to mention fundraising to their board members. Yet, helping to raise funds has everything to do with making sure the charity remains financially sound.

Finances are not just about overseeing the budget. It is about understanding how the organization is funded, how fundraising works and participating in that fundraising.

So do consider the fundraising potential of every board member. That doesn't mean that every board member should be wealthy. However, they are expected to set an example by donating to the organization and soliciting other contributions. Every board member should participate in giving in the way that they can afford.

Many successful nonprofits require a donation to the organization from their board members, The amount required doesn't have to be extraordinarily high. It's the commitment that is important.

Board members should be comfortable with fundraising. In fact, the most successful nonprofits have active and engaged boards.They give personal gifts, and they participate in fundraising campaigns.

When you recruit and train board members, you should make their fundraising duties clear. Not everyone will want to call personally on donors, but they can do something.

Make a list of ways to help with fundraising such as writing thank you notes or calling donors to say thanks. Board members should be able to  identify potential major donors and make an introduction. Suggest that board members solicit items from businesses for your annual auction or help organize a fundraising event.

Keep board members active. No one gets a free pass. Just showing up for board meetings is not enough.


text:
Workshop 16-18 September 2015: Mathematical and Computational Techniques for Molecular Systems at FORTH, University of Crete - ACMAC
The study of complex molecular systems through mathematical and computational approaches is an emerging research area due to enormous range of basic scientific problems and technological applications related to such materials. The rigorous from the mathematical point of view, based on statistical mechanics, foundation of simulations can be of significant importance for the prediction of the structure-properties relations of molecular systems.
Our intention is to bring together a small but diverse group of experts working on modeling, analysis and computational aspects of molecular systems, using the workshop also as a mechanism to get together and interact during the stay in Crete. In the realm of statistical mechanics and simulations of molecular systems, we seek intertwined discussions along the following paths:
Theoretical: Modern mathematical approaches based on statistical mechanics, as well as general coarse-graining theories, is a very active interdisciplinary field nowadays.
- Computational: Simulation schemes are required in order to implement these theoretical approaches on various molecular systems.
The above discussions will focus on a variety of problems from simple fluids, polymers, hybrid nanocomposite systems, biomolecular systems, etc.
The workshop is supported by FORTH and will take place in Archimedes Center for Modeling, Analysis and Computation, ACMAC, at the University of Crete, during 16-18 of September.
Tentative Program:
We plan talks (T) of about 45min + 15min for discussion, short coffee breaks (CB) and longer lunch breaks (LB).


text: This post is a simple and quick solution to stuffed animal storage. Screw a cup hook into the wall, latch a canvas bag onto the hook and plop stuffed animals into the bag. Here's how it ended up looking in my daughter's room:As you can see, I hung up a large stuffed animal (with thumb tacks) beside the bag so that it looks like the plushie is holding the bag. Fun right? If you hang the bag low enough, your child can snag their favorite animal from the canvas bag anytime they like.


text:
CGS Website
Anggaran €30-250 EUR
I have a website ([url removed, login to view]) and I would like it updated with a new modern theme - also to work on all devices.
We need some forms in there so that people can register an interest and we also need a form when we put up food options for guests to choose from.
Some space should be left at the bottom for our sponsor's logos too.
It is hosted on godaddy and has wp installed.
I've attached some files as I'd like the site to have a friendly feel.
Diberikan kepada:
I am ready to start your project , just start chat and we can discuss in detail , i assure you that you will be provided quality work. Waiting for your kind reply...
18 freelancer menawar dengan rata-rata €214 untuk pekerjaan ini
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Search the Guide:
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Halle Berry's troubles start at sea
Halle Berry has revealed she got "terribly seasick" when she shot Dark Tide.
The Oscar-winning actress, who plays shark whisperer Kate in the underwater thriller, admitted that fiance Olivier Martinez - who stars as her screen boyfriend Jeff - got the brunt of her queasiness.
"My first day on the boat, I'm not ashamed to say I got terribly seasick - I threw up about five times, but it never happened since. I got my sea legs and have not been sick one day since," she said.
She recalled: "That first day, there were very high waves so it was very choppy. Half our crew was chucking up. I couldn't help it but I threw up on Olivier's shoes!"
Halle revealed that filming in the middle of the ocean by Cape Town was one of the challenges of the shoot.
"We are out there in the middle of nowhere on a little boat and on most days there are around 20 men and women on that little boat trying to make a movie, with all these tight corners, in a very constricted space. Which is an acting challenge - something I had to learn how to do," she admitted.
"We had to find a little corner and deal with whatever the process is at that time, and sometimes we couldn't prepare at all but just have to hit the deck running," she added.
Dark Tide is released on DVD and Blu-ray by Revolver Entertainment on October 22.


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Target: Ecuadorean President Rafael Correa
Goal: End terrorism against indigenous leaders in Ecuador, who are simply trying to save their homelands and people from exploitation.
The world is increasingly turning its attention to the few places that have not yet been drilled for oil, logged, mined, or exploited. The only problem? People live there already and don't want their homeland to turn into a strip mine. When indigenous leaders go to speak up about their rights, they are often threatened or murdered, like indigenous Shuar leader José Isidro Tendetza. This is terrorism, plain and simple, and it targets some of the world's most vulnerable people.
At least 116 environmental activists around the world were murdered in 2014 and the numbers rise every year. 40% of them are indigenous. According to those statistics, the number of indigenous activists murdered is twice the number of journalists–including war journalists–that have died violent deaths. This is unacceptable.
As a prime example, lawyer Mario Melo alleges that the government in Ecuador did not obtain consent from indigenous Shuar people to allow a Chinese company to drill on their homelands; three indigenous leaders have since died violent deaths in the past six years. José Isidro Tendetza is the third death. He filed a complaint against the Chinese company and set out to attend a protest meeting; his body was found four days later in an unmarked grave, showing signs of torture and strangulation. The cause of death was originally termed drowning, and his family expresses a growing lack of faith in the Ecuadorean government to actually prosecute the correct criminals. Terrorism is the only word for what the Tendetza family's persecution is a symptom of: violence intended for the pursuit of political aims. End this now.
Dear President Correa,
You made promises to the world and your people about respecting the environment in Ecuador. Uphold these promises and don't turn a blind eye to terrorism against your own citizens. You should not discount people willing to die for what you term "infantile environmentalism." Selling out your forests and your people is not the way to reach real prosperity and such actions are beyond the pale, morally. It is also shortsighted. Mining is only a finite source of wealth.
If you are seeking to pay back your debts to China, surely there are other ways to accomplish this objective than condoning environmental degradation and human rights abuses. By covering up or ignoring terrorism, you condone it. Your people will lose faith in government channels and use other routes to achieve their demands. This all chips away at rule of law and, ultimately, it is a strong rule of law–keeping promises, building trust, creating norms for following the law because the law is trustworthy–that will help your country in the long run. The Shuar people have existed on their homelands for far longer than Ecuador has been a country. If they don't have a legal right to their homeland, then who does?
[Your Name Here]
Image Credit: Sarah Driver


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Italian mobile internet users overtake desktop only users
According to data captured by comScore, in March 2017 9.3 million (24.9%) of the country's 37.3 million internet users accessed the internet exclusively via smartphone or tablet in March. By comparison, 9.1 million (24.3%) did so solely from a desktop or laptop computer. Just over half (51%) of Italy's internet users employed both mobile and desktop devices to go online during the month, up 4 percentage points from the 47%... Read More
New survey reveals publishers are seeing rapid rise in Native ad revenues
A recent survey by AdsNative entitled 'The State of Native Advertising 2017 (According to Publishers)' has revealed some very interesting statistics. The survey is based on the analysis of 7,500 web and mobile publishers during Q1 2017. As the Native ad format becomes more available a staggering 92.3% of the publishers in the survey have seen their native ad revenues increase in the last year, additionally, 68.9% have been monitoring... Read More
PageFair Adblock report 2017
The latest report from PageFair shows that the number of devices using an ad blocker increased by 30% in 2016, with much of that increase coming from users in Asia-Pacific, where 16% now use ad blockers.. Adblocking on desktop and laptop devices in the USA has grown at a higher rate than the global average, at 18%, with the global average being 11%. However, on mobile the vast majority of... Read More
China is more mobile than ever
Mobile internet in China has now pushed through the 50% threshold, according to the 39th China Internet Development Statistics Report, complied by the Chinese government agency responsible for the internet. As of December 2016, China had 731 million internet users. That figure represents 53.2 percent of China's population, meaning that it is almost on par with the population of Europe: 743 million people. But, perhaps more impressively, 95 percent of... Read More
Mobile internet use overtakes desktop for the first time
For the first time more users are accessing the internet from mobile devices than from desktop computers. That is according to internet monitoring firm StatCounter. The combined traffic from mobile and tablet devices tipped the balance at 51.2 % versus 48.7% for desktop access. In emerging markets such as India, mobile is by far the preferred way to access the internet with a staggering 75% of users using mobile only.... Read More
Latest UK mobile statistics and advertising data
British consumers' obsession with their mobile devices has been capitalised upon by marketeers and their digital ad spend. According to PWC and IAB, for the first time in the first half of 2016, UK figures show that more digital display budget was being spent on mobile (£802m) than on PC and tablet (£762m). The figures also revealed that overall digital ad spending is up 16%, with mobile digital ad spend... Read More
Mobile predicted to generate highest media spend in 2016
A new report by global media agency Carat predicts that by the end of 2016 mobile will generate the highest spend across all media, with a year-on-year to increase by 49%, beating earlier predictions of 38%. The data is taken from 59 markets in the Americas, Asia Pacific and EMEA. In Europe, the UK continues to be the number one ranked advertising market, with 5.4% growth in 2016 and a... Read More
Are UK consumers finally realising that ads keep the internet free?
According to BizReport, the latest quarterly report from the Internet Advertising Board UK and YouGov states that the number of UK adults using ad blockers did not change significantly between February 2016 (21.7%) and July 2016 (21.2%). Interestingly, it seems that the value exchange message is beginning to sink in with the British consumer as they realize that ads online fund free content and services, and that the alternative to... Read More


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Summer is here and with it, of course, comes the heat. When it comes to making dinner, I'm not looking for heavy comfort food like the cooler months. I prefer easy dinners with entrees cooked on the grill and cold sides like Creamy Pesto Fingerling Potato Salad or Tomato and Basil Pasta Salad. The same goes for desserts. I prefer not to turn on my oven and bake, but occasionally still want to serve a sweet treat for dessert. These super easy No Bake Chocolate Strawberry Stacks fit the bill perfectly when you don't want to turn on the oven.
Fresh strawberries seem to be in abundance in my local markets. Grabbing a few pints of fresh berries and few extra ingredients lets you create a stunning dessert in just minutes. You can really use any type of fresh berry in this dessert and it will be spectacular.
Assembling this dessert couldn't be easier. Simply start with a chocolate wafer, add a layer of sliced strawberries, and then top with a dollop of whipped cream.
Next time I may try adding some diced strawberries into the whipped cream. I think it would be a fab contrast of tastes and texture with the fresh whipped cream.
If you can't seem to find the chocolate wafer cookies in your local store, try checking in the ice cream topping section. Once you have the first set of layers complete, then repeat to create the stacks as high as you desire.
These no bake desserts are light and amazing! The cookie softens as the stacks set and the wafers make for a cake-like experience. Perfect recipe for summer! I can't wait to mix and match different berry combinations.
The recipe makes about 9-12 desserts, depending on the amount of whipped cream you use. Everyone will surely devour this dessert, and I personally wouldn't plan ahead for any leftovers.
What's your favorite Summer No Bake dessert recipe?
- 1 box Famous Chocolate Wafer Cookies (3 cookies per dessert)
- 8 ounces heavy whipping cream
- 3 tablespoons powdered sugar (more if you want it sweeter)
- Fresh Strawberries washed and sliced, (about 3 berries per dessert)
- Fresh Mint for garnish (optional)
- In a stand mixer using the whisk attachment, whisk the sugar and whipping cream until stiff. About 2-3 minutes on high.
- Add additional sugar to taste if desired.
- To assemble Chocolate Strawberry Stacks, place one cookie on a plate and top with sliced berries. Add a dollop of whipping cream and top with a cookie. Repeat until you've placed a third cookie on top.
- Garnish with a small dollop of cream, strawberry and mint leaf.


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Can You Come?
October 5th, 2010 in About Me
Our site, SassyScoops.com, helps promote LOCAL LOCAL LOCAL! We do a "GNO" twice a year and our fall GNO is THIS Thursday. Will you come? With five out of the nine Sassies either having babies or recently having given birth, who knows when we will get around to planning another one?
So you should all come. Here are the details:
Yes, in that picture I am YAWNING. Alas, my friends don't love me enough to take the darn picture of me out! Ahh, it's funny. Oh well. Also, I promise not to yawn Thursday night.
Tags: sassyscoops.com


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Profound Inhibition of Myogenic Tone in Rat Cardiac Allografts Is Due to eNOS- and iNOS-Based Nitric Oxide and an Intrinsic Defect in Vascular Smooth Muscle Contraction
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Background—The physiological consequences of inducible NO synthase (iNOS) expression were studied in allograft coronary arteries by pressure myography.
Methods and Results—Septal coronary arteries (diameter, 200.6±3.3 μm) were harvested from allograft and isograft hearts, and their myogenic properties were measured before and after iNOS and nonselective NOS inhibition with aminoguanidine (AG, 100 μmol/L) and NG-nitro-l-arginine methyl ester (L-NAME) (200 μmol/L). Fura 2 fluorescence microscopy was used to measure [Ca2+]i in isolated endothelial cells. Monoclonal anti-iNOS immunostains demonstrated iNOS protein in day 2, 7, 14, and 28 allograft vessels, but only in day 2 isograft vessels. Myogenic tone was profoundly inhibited in allograft vessels from day 4 onward. In day 4 allograft vessels, these differences were abolished by L-NAME but not AG, suggesting greater basal release of eNOS-based NO from allograft endothelium. Fluorescence measurements confirmed elevation of [Ca2+]i in day 4 allograft endothelium, providing a mechanism for enhanced eNOS activity. For days 7 to 28, AG potentiated myogenic tone in allograft but not isograft vessels, indicating that vasoactive iNOS-based NO was present. In mature vessels, constriction via agonist- and depolarization-mediated mechanisms showed parallel inhibition, suggesting an intrinsic defect in vascular smooth muscle cell contraction.
Conclusions—Our data indicate that the profound inhibition of myogenic tone in allograft arteries involves direct vasodilation by eNOS- and iNOS-based NO, as well as an intrinsic defect in vascular smooth muscle contraction. The hemodynamic profile resulting from these changes in allograft resistance vessel function would favor movement of extracellular fluid from the intravascular space into the myocardial interstitium, resulting in edema, increased ventricular stiffness, and poor ventricular performance.
Nitric oxide (NO) has recently been proposed to play an important role in transplant physiology, with several investigators having identified the inducible isoform of NO synthase (iNOS) in experimental and human cardiac allografts but not isografts.1 2 3 Unlike the constitutively expressed endothelial NOS (eNOS), which normally produces low basal levels of NO in a manner very tightly regulated by endothelial intracellular Ca2+, iNOS activity is Ca2+-independent and is regulated largely by the amount of enzyme present; thus, iNOS is capable of producing large quantities of NO for sustained periods of time.4 The coronary vasculature could be a target of iNOS-based NO, leading to sustained vasodilation of resistance vessels and increased coronary flow. During biopsy-proven cellular rejection in human cardiac allografts, basal work-corrected coronary flow is elevated, with a corresponding decrease in flow reserve, indicating enhanced dilation of the coronary circulation under immune assault.5 On the basis of this evidence, we hypothesized that the expression of iNOS in cardiac allografts would result in the production of NO and enhanced vasodilation. Our results indicate that the basal myogenic tone of isolated allograft arteries is profoundly inhibited, occurring through NO-dependent and NO-independent mechanisms.
iNOS and eNOS expression
iNOS expression was clearly evident in day 2, 7, 14, and 28 allograft arteries (Figure 1⇓). In contrast, isograft arteries showed clear iNOS expression only at day 2 posttransplantation, with infrequent staining for subsequent time points. Notably, day 4 lacked iNOS expression in both groups. Thus, allospecific iNOS expression is first identified at day 7 and persists at day 28, whereas transient nonspecific iNOS expression (allografts and isografts) occurs at day 2. eNOS protein was identified in allograft and isograft arteries at all time points.
Vascular Functional Studies
Vessel Size and Structure
The average diameter for all vessels was 200.6±3.3 μm at 10 mm Hg in Ca2+-free physiological salt solution (PSS) (n=85). For all graft and time-point groups, pressure-diameter curves in Ca2+-free PSS were similar, indicating identical passive characteristics.
Myogenic Tone
Day 2 Posttransplantation.
Isograft and allograft vessels showed similar myogenic profiles at day 2; myogenic tone developed in a graded fashion as transmural pressure was increased in the physiological range. In both groups, there was a nonsignificant trend toward greater tone after aminoguanidine (AG), indicating the presence of iNOS-based vasoactive NO (Figure 2A⇓). NG-Nitro-l-arginine methyl ester (L-NAME) resulted in similar potentiation in both groups, indicating equal underlying myogenic tone (Figure 2B⇓).
Day 4 Posttransplantation.
In contrast to day 2, significant differences in myogenic tone were evident between isograft and allograft vessels at day 4. AG did not potentiate tone in either group, indicating an absence of iNOS-based NO (Figure 3A⇓). However, nonselective NOS inhibition with L-NAME abolished the tone differences. This observation suggests greater basal release of eNOS-based NO in allograft vessels (Figure 3B⇓).
Because eNOS activity is [Ca2+]i-dependent, we reasoned that enhanced Ca2+ availability in allograft endothelial cells might underlie the enhanced eNOS activity in day 4 allografts. We used fura 2 fluorescence imaging to study [Ca2+]i homeostasis in freshly isolated aortic valvular endothelial cells from day 4 allograft and isograft hearts. A representative tracing, along with cumulative data, is shown in Figure 4⇓. Calculated basal [Ca2+]i was significantly elevated in allograft endothelium (78.3±4.9 versus 42.8±5.7 nmol/L; 35.6±5.7 nmol/L [control], P<0.05 allograft versus isograft and control). Inhibition of the endoplasmic reticulum Ca2+-ATPase with cyclopiazonic acid (CPA) in the presence of extracellular Ca2+ caused a large increase in 340/380 ratio in allograft endothelium. In isografts and controls, the increase was small and transient. The elevated 340/380 ratio in allografts could not be rapidly reversed by tetraethylammonium (TEA) (which depolarizes the endothelial cells, thus decreasing the electrical driving force for Ca2+ entry); even removal of CPA caused a very slow decrease in 340/380 ratio. When Mn2+ quenching of the 360-nm signal was used as a reflection of Ca2+ influx, no differences between allograft and isograft cells were observed, although both were elevated compared with control cells.
Days 7 to 28 posttransplantation.
Inhibition of allograft myogenic tone persisted for days 7 to 28. The tracings in Figure 5⇓ demonstrate the profound vasodilation of an allograft artery compared with a matched isograft artery. For days 7 to 28, incubation with AG abolished the statistical differences between isograft and allograft vessels, indicating that iNOS-based NO is present and is vasoactive (Figure 6A⇓ through 6C). However, a trend toward less tone in allograft vessels persists after AG, suggesting either incomplete iNOS blockade, greater eNOS activity, or another mechanism of tone inhibition. In these vessels, L-NAME unmasked a time-dependent deterioration of underlying myogenic tone in allograft groups (Figure 7A⇓). Neither indomethacin 1 μmol/L nor endothelium removal could reverse the profound inhibition of tone in L-NAME–treated day 28 allograft arteries (not shown).
Agonist- and Potassium-Induced Tone
Allograft and isograft vessels (with AG) were constricted by agonist and depolarization (potassium) mechanisms for comparison with myogenic tone. As shown in Figure 7B⇑, there is a parallel inhibition of these 3 mechanisms of constriction in mature allograft vessels (day 28), whereas all 3 are preserved in early allografts and matched isografts. This pattern of multimodal inhibition suggests a decrease in the number of viable or functional smooth muscle cells,6 7 or possibly a signaling defect in the distal common pathway of constriction.
Graft Weight and Wet/Dry Ratios
Dry weight was greater in allografts than in matched isografts from day 4 onward. Wet/dry ratio was significantly elevated in day 4, 7, and 28 allograft hearts, indicating greater myocardial free water content (Table⇓).
Drugs and Concentrations
Previous work has shown inhibition of iNOS in vascular preparations by 100 to 300 μmol/L AG.8 9 10 11 12 Figures 3A⇑, 4A⇑, and 7A⇑ through 7C show potentiation of tone only in vessels expressing iNOS protein. We observed preservation of acetylcholine-induced dilation in native arteries in the presence of 100 μmol/L AG; 200 μmol/L L-NAME abolished acetylcholine-induced dilation, indicating complete blockade of eNOS (not shown).
The principal finding of this study is that myogenic tone in allograft coronary arteries is profoundly inhibited compared with site- and size-matched isograft arteries, resulting in a greatly enhanced arterial diameter. We have identified 3 mechanisms: (1) tone inhibition can occur through enhanced basal release of eNOS-based NO due to enhanced endothelial Ca2+ availability; (2) when iNOS is expressed, tone inhibition can occur through release of iNOS-based NO; and (3) in contrast to the NO-dependent vasodilation mechanisms mentioned above, the concerted deterioration of pressure-, agonist-, and depolarization-induced tone seen in mature allograft vessels is consistent with an intrinsic defect in vascular smooth muscle contraction, involving either common signal transduction events or a decrease in the number of viable smooth muscle cells. These findings, which precede the obliterative arteriopathy characteristic of chronic rejection, predict a pattern of coronary hemodynamics that would favor movement of extracellular fluid from the intravascular compartment into the myocardial interstitium, resulting in myocardial edema and ventricular stiffness.
Mechanisms of Myogenic Tone Inhibition
eNOS and Endothelial [Ca2+]i
Arteries from allografts at day 4 manifest less myogenic tone than matched isograft arteries. Selective iNOS inhibition with AG did not potentiate tone in either group, and no iNOS protein was identified immunohistochemically. The tone differences were abolished after nonselective NOS inhibition with L-NAME, indicating a greater basal release of eNOS-based NO from allograft endothelium. Resting 340/380 ratio (and calculated [Ca2+]i) was elevated in isolated allograft endothelial cells; because eNOS is very tightly regulated by [Ca2+]i, this observation provides a mechanism for enhanced basal release of eNOS-based NO.
iNOS-Based Vasoactive NO
From day 7 onward, the inhibition of myogenic tone in allograft arteries paralleled the expression of iNOS protein. In these vessels, selective inhibition of iNOS with AG potentiated tone; thus, iNOS-based NO is vasoactive and is an important mechanism of tone inhibition. To our knowledge, this is the first report to show immunohistochemical evidence of iNOS protein together with vascular hyporesponsiveness and iNOS inhibitor potentiation of resistance vessels. The general theme, however, has been addressed in other models.10 11
Smooth Muscle Contractile Defect
A trend toward less tone in day 7 to 28 allografts persists even after iNOS inhibition. These residual differences could be due to alloimmune alteration in endothelial [Ca2+]i as described above; in mature grafts, however, the residual differences in tone were not abolished by nonselective NOS inhibition. In fact, this approach unmasked a pattern of progressive, time-dependent deterioration of myogenic tone that is not solely due to NO vasodilation, arguing against eNOS as a preeminent factor. Because neither indomethacin nor endothelium removal altered this residual inhibition, prostaglandins and other endothelium-derived vasodilators were eliminated as candidate mechanisms. In these mature (day 28) allograft vessels, profound inhibition of myogenic, agonist, and depolarization-induced tone was observed, suggesting a defect in vascular smooth muscle contraction through a common signaling event. Potential events include those of the distal common pathway: Ca2+ influx, calmodulin, myosin light chain kinase, contractile filaments, and phosphatases.
It is also possible that the impairment of constriction in mature allograft vessels is due to a decrease in the number of viable smooth muscle cells. Apparent loss of medial cells has been observed by Dong et al13 in human coronary arteries, and recent evidence indicates that apoptosis may play a key role in cardiac allograft vasculopathy. Szabolcs et al14 used DNA laddering, terminal dUTP nick end-labeling (TUNEL), and in situ nick translation to identify apoptotic cells in Lewis-to–Wistar-Furth allografts. Apoptotic nuclei were identified in cardiac myocytes, endothelial cells, and infiltrating monocytes; iNOS protein was identified in the same cell types. Importantly, the temporal pattern of apoptosis paralleled that of iNOS expression, NOS activity, and nitrotyrosine staining, suggesting that apoptosis may be triggered by iNOS and peroxynitrite. With this in mind, it is possible that the effect of iNOS expression on allograft arteries is 2-fold and time-dependent: an early phase due to vasodilation by NO itself and a delayed phase due to smooth muscle apoptosis by NO and/or NO adducts.
iNOS Protein Expression
Expression of iNOS mRNA and protein has been demonstrated in cardiac allografts from several heterotopic animal models, and our analysis is similar to these.1 2 In the Lewis-to-F344 model, reverse transcription–polymerase chain reaction on ventricular homogenate RNA identified iNOS transcript in allografts at days 7, 14, 28, and 75, with a small amount at day 3. Immunohistochemical stains with polyclonal rabbit antisera to macrophage NOS showed iNOS protein predominantly in mononuclear inflammatory cells within the interstitial and perivascular spaces of allograft hearts (days 7, 28, and 75); there was minimal staining in isografts. iNOS protein in smooth muscle and endothelial cells was identified in significant quantity only at later time points (days 75 and 120), although lesser staining was seen in all allografts.2 Our results with a monoclonal mouse anti-iNOS antibody show that allospecific expression of iNOS in day 7 to 28 allograft arteries occurs mainly in the intimal space. In this location, NO from functional iNOS would be expected to have access to the vascular smooth muscle with resistance vessel sequelae as we have shown. Our structure-function comparison demonstrates that the pattern of iNOS expression parallels the pattern of functional change in allograft vessels and confirms an important physiological consequence of iNOS expression in transplantation.
Clinical Significance
Our experimental observations provide a mechanistic basis for several clinical observations. In the absence of fixed distal disease, a pattern of enhanced arterial diameter due to myogenic tone inhibition would predict a hemodynamic profile of supranormal coronary flow and reduced flow reserve. In nonrejecting human cardiac grafts, resting coronary flow is indeed elevated, with a proportional decrease in flow reserve15 16 ; these findings have been attributed to increased cardiac work in recipients with systolic hypertension and tachycardia, and when corrected for this, coronary flow is appropriate. However, during biopsy-proven acute rejection, corrected coronary flow is significantly elevated (and coronary resistance depressed) compared with flow after successful recovery on immunosuppression,4 indicating that vasodilation accompanies uncontrolled graft rejection. Interestingly, corrected coronary flow remains significantly elevated after a single episode of rejection compared with patients without previous rejection episodes, consistent with a persistent defect in resistance vessel tone due to the rejection event. Because iNOS expression in cardiac allografts is inhibited by immunosuppression,17 it is possible that the residual elevation in resting corrected coronary flow in transplant patients after rejection is due to an iNOS-independent event such as enhanced endothelial [Ca2+]i and NO or a smooth muscle contractile defect, as we have shown. If so, these alterations in resistance vessel function may be irreversible.
Elevated coronary flow in the face of an unrestrained immune assault may at first consideration appear to be an appropriate and beneficial response. However, normal coronary myogenic behavior is necessary not only to regulate myocardial blood flow but also to provide graded vascular resistance. Appropriate vascular resistance protects the microvasculature from central arterial pressures and so preserves the important balance of hydrostatic and oncotic forces at the capillary and venular levels.18 A massively dilated coronary circulation, predicted by our results, would transmit abnormally high perfusion pressures to nutritive vessels, distorting the balance of intravascular oncotic and hydrostatic pressure and favoring a net movement of fluid into the myocardial interstitium. In support of this hypothetical pathogenesis, our results show a greater wet/dry ratio in allograft hearts, reflecting greater myocardial free water content. Because endothelial permeability to serum protein is enhanced in allograft rejection (also an iNOS-dependent event),19 these 2 mechanisms could act synergistically to cause significant myocardial edema, thereby compromising ventricular compliance and performance.
The association between iNOS expression and ventricular performance in human grafts was recently published. In support of our hypothesis that the altered allograft coronary physiology (in part due to iNOS-based NO) would favor myocardial edema, ventricular stiffness, and poor performance, Lewis et al3 reported that expression of iNOS correlates with cGMP levels and systolic and diastolic left ventricular contractile dysfunction; importantly, iNOS did not associate with International Society of Heart and Lung Transplantation (ISHLT) rejection grade. Together with our results, this key study indicates that current techniques of rejection assessment (ISHLT grade) may ignore coexistent physiological mechanisms of allograft dysfunction.
Summary and Conclusions
We have shown that myogenic tone is profoundly inhibited in cardiac allograft arteries, in part by excess vasoactive NO and in part by a defect in vascular smooth muscle contractility. Excess NO can be derived from eNOS and iNOS isoforms. These findings predict a hemodynamic pattern within the rejecting heart that would favor myocardial edema, ventricular stiffness, and poor myocardial performance.
Transplants, Immunostains, and Tissue Preparation
Heterotopic cardiac transplants were created with anastomosis of donor ascending aorta to recipient abdominal aorta and donor pulmonary artery to recipient inferior vena cava.20 Hearts were harvested at days 2, 4, 7, 14, and 28 for immunohistochemical and functional studies. This protocol was in accordance with Animal Care Guidelines set forth by the University of British Columbia.
Standard immunohistochemical techniques were used to demonstrate iNOS and eNOS protein in fresh cardiac tissues. Fresh rat cardiac tissues from isograft, allograft, and normal control animals were harvested on days 2, 4, 7, 14, and 28, embedded in OCT compound, quick-frozen on dry ice, and stored at −80°C until analysis. Mouse monoclonal anti-iNOS and anti-eNOS antibodies (both from Transduction Laboratories) with biotinylated horse anti-mouse secondary antibody amplification and streptavidin-biotin detection were used for protein determination. For both antibodies, negative controls included (1) omission of the primary antibody and (2) use of an irrelevant, isotype-matched primary antibody at an equivalent concentration.
Septal coronary arteries (inner diameter, ≈200 μm) were obtained from grafted (n=75) and control (n=10, unoperated Lewis) hearts and were used for all functional studies. Through a right ventriculotomy, the septal coronary artery was identified on the ventricular septum. A segment of the vessel 0.6 to 1.0 mm long was dissected free of surrounding myocardium at the level of the superior septal papillary muscle, excised, and transferred to the experimental chamber of a pressure myograph as described previously.21 The artery was mounted between 2 microcannulas and then gradually pressurized to allow development of myogenic tone. The transilluminated image was then used to determine arterial diameter response to changes in transmural pressure.
For fluorescence experiments, endothelial cells were freshly isolated from isograft and allograft aortic valve leaflets by a previously described enzyme digestion method.22 The isolated cells were seeded onto glass coverslips precoated with poly-d-lysine and maintained at 37°C until transfer to the experimental perfusion chamber. The final preparation consisted of small clusters of 3 to 15 cells that maintained their typical tile-like morphology. [Ca2+]i of the isolated endothelial cells was evaluated by use of a fura 2fluorescence imaging system and the method of Grynkiewicz et al.23 We recognize the uncertainties of [Ca2+]i calculation by this fura 2 calibration method.24 Therefore, we elected to compare fluorescence intensity ratios between groups rather than their calculated [Ca2+]i. A Mn2+-quenching technique was used to study the rate of divalent cation influx into the isolated endothelial cells.
Myogenic, Agonist-Induced, and Depolarization-Induced Tone
After equilibration at 80 mm Hg, transmural pressure was decreased to 10 mm Hg. Vessels were subjected to stepwise increases in transmural pressure, from 10 to 120 mm Hg, to determine the degree of myogenic tone at each pressure. This protocol was repeated in the presence of inhibitors of NO synthases, and so 3 trials were completed: (1) physiological salt solution (PSS) alone, (2) iNOS inhibition with aminoguanidine (AG) 100 μmol/L, and (3) nonselective NOS inhibition with NG-nitro-l-arginine methyl ester (L-NAME) 200 μmol/L. The vessel was then cycled through the same pressure steps in Ca2+-free PSS to determine the passive diameter at each pressure. Constrictions in response to the thromboxane analogue U46619 10 μmol/L and potassium 80 mmol/L were measured in a separate group of arteries pressurized at 80 mm Hg.
Endothelial Ca2+ Signaling
To study the level and determinants of basal [Ca2+]i in isolated endothelial cells, 340/380 fluorescence intensity ratios were measured sequentially at rest, after endoplasmic reticulumCa2+-ATPase inhibition with cyclopiazonic acid (CPA, 10 μmol/L), after K+-channel blockade with tetraethylammonium (TEA, 5 mmol/L), and after washing with PSS. The rate of Mn2+ quenching was subsequently determined in the same cells.
Myogenic tone, expressed as percent constriction, was calculated as (DCa2+-free, P−DP)/DCa2+-free, P, where DCa2+-free, P is the diameter in Ca2+-free PSS at pressure P, and DP is the diameter in PSS with calcium at pressure P. Constrictions to agonist and potassium at 80 mm Hg were calculated similarly.
The ionic composition of PSS (in mmol/L) was NaCl 118, NaHCO3 24.9, KH2PO4 4.7, MgSO4 1.17, CaCl2 1.6, glucose 11.1, and EDTA 0.026. Potassium PSS was prepared by proportional mixing with 80 mmol/L KCl-PSS. Ca2+-free PSS contained 2.0 EGTA and no CaCl2.
Statistical Analysis
Results are presented as mean±SEM. Data were analyzed with Student's t test or 1-way/1-way repeated-measures ANOVA where appropriate and Student-Newman-Keuls or Dunn's test for significant differences. The probability of a type I (α) error was set at P<0.05.
Drs Skarsgard and Laher are supported by the Medical Research Council of Canada. Drs van Breemen and McManus are supported by the Heart and Stroke Foundation of British Columbia and the Yukon (both by grants-in-aid and a program project award), Biomax Technologies, and the St Paul's Hospital Foundation. The authors acknowledge the technical assistance of Dean English, Jennifer Kenyon, and Janet Wilson-McManus.
The Methods section of this article can be found at http://www.circulationaha.org
- Received April 8, 1999.
- Revision received September 30, 1999.
- Accepted October 8, 1999.
- Copyright © 2000 by American Heart Association
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Yang X, Chowdhury N, Bolin C, Brett J, Marboe C, Sciacca RR, Michler RE, Cannon PJ. Induction of myocardial nitric oxide synthase by cardiac allograft rejection. J Clin Invest. 1994;94:714–721.
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Russell ME, Wallace AF, Wyner LR, Newell JB, Karnovsky MJ. Upregulation and modulation of inducible nitric oxide synthase in rat cardiac allografts with chronic rejection and transplant arteriosclerosis. Circulation. 1995;92:457–464.
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Lewis NP, Tsao PS, Rickenbacher PR, Xue C, Johns RA, Haywood GA, von der Leyen H, Trindade PT, Cooke JP, Hunt SA, Billingham ME, Valantine HA, Fowler MB. Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricle. Circulation. 1996;93:720–729.
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Chan SY, Kobashigawa J, Stevenson LW, Brownfield E, Brunken RC, Schelbert HR. Myocardial blood flow at rest and during pharmacological vasodilation in cardiac transplants during and after successful treatment of rejection. Circulation. 1994;90:204–212.
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Meininger GA, Davis MJ. Cellular mechanisms involved in the vascular myogenic response. Am J Physiol. 1992;263:H647–H659.
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Schrör K. The effect of prostaglandins and thromboxane A2 on coronary vessel tone: mechanisms of action and therapeutic implications. Eur Heart J. 1993;14(suppl I):34–41.
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Szalbolcs M, Michler RE, Yang X, Aji W, Roy D, Athan E, Sciacca RR, Minanov OP, Cannon PJ. Apoptosis of cardiac myocytes during cardiac allograft rejection: relation to induction of nitric oxide synthase. Circulation. 1996;94:1665–1673.
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Kofoed KF, Czernin J, Johnson J, Kobashigawa J, Phelps ME, Laks H, Schelbert HR. Effects of cardiac allograft vasculopathy on myocardial blood flow, vasodilatory capacity, and coronary vasomotion. Circulation. 1997;95:600–606.
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- Profound Inhibition of Myogenic Tone in Rat Cardiac Allografts Is Due to eNOS- and iNOS-Based Nitric Oxide and an Intrinsic Defect in Vascular Smooth Muscle ContractionPeter L. Skarsgard, Xiaodong Wang, Paul McDonald, Amy H. Lui, Eugene K. Lam, Bruce M. McManus, Cornelis van Breemen and Ismail LaherCirculation. 2000;101:1303-1310, originally published March 21, 2000https://doi.org/10.1161/01.CIR.101.11.1303
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- Profound Inhibition of Myogenic Tone in Rat Cardiac Allografts Is Due to eNOS- and iNOS-Based Nitric Oxide and an Intrinsic Defect in Vascular Smooth Muscle ContractionPeter L. Skarsgard, Xiaodong Wang, Paul McDonald, Amy H. Lui, Eugene K. Lam, Bruce M. McManus, Cornelis van Breemen and Ismail LaherCirculation. 2000;101:1303-1310, originally published March 21, 2000https://doi.org/10.1161/01.CIR.101.11.1303Permalink:


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Willow Holt Pumping Station
Constructed in 1980 as part of the North Level Major Improvement Scheme. It was designed to evacuate surplus water from an area of 590 hectares of predominantly agricultural land, but there are approximately 120 houses the benefit from the protection given by the Pumping Station.
Willow Holt Pumping Station consists of two 350mm diameter axial flow Allen Gwynnes pumps, each with a capacity of 24 T/min or 0.41 cumecs, powered by Mather & Platt 24kw electrical motors. The pumps and electric motors are of all weather construction, the electrical control switchgear being housed in a purpose built brick building. The pumps discharge directly into the North Level Main Drain via twin steel pipelines some 10m long.
Go to the Catchment and Pumping Stations map.


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We've all seen plenty of baseball fights and most of the time they are pretty silly. The benches clear. A bunch of guys push and shove a little. Then they go back to their respective dugouts. Unfortunately, that's not what happened when the Dodgers and Padres went at it on Thursday night and it's likely going to cost L.A. big time.
The Dodgers won the game against San Diego 3-2, but there's no question they lost the fight, as their marquee offseason acquisition, Zack Greinke broke his collarbone in the scuffle.
After drilling Carlos Quentin in the shoulder with a pitch in the sixth inning, Quentin charged, taking Greinke down and inducing both teams to pile on, which is what likely caused the injury.
But regardless of how it happened, there's a much bigger question looming over Dodger nation at the moment. Just how much is this going to hurt?
In terms of monetary measures, it will likely hurt the organization quite a bit. Greinke's signing was a huge deal this offseason to fans and the deal itself was huge for Greinke – $147 million worth to be exact. The Dodgers certainly won't be thrilled signing off massive checks to a guy on the DL and they certainly will be livid if the team can't pick things up in his absence, which would result in losses, which in turn, could result in lower attendance.
Speaking of which, it will likely hurt the team in terms of wins and losses as well. Greinke's acquisition suddenly made the Dodgers many people's pick to win the NL West, for some, even the NL pennant. Although we're not sure how many games he will miss with the injury (he'll probably have to be evaluated), we can safely say those odds will be affected, especially since the Giants look just as good as they did last year when they won the World Series.
So how much does the injury impact the team? It's not something you can measure exactly, but there's no question that bettors will be less inclined to take L.A. in futures wagers. Here's what we do know: The Dodgers have a smaller chance to win games in which he doesn't start; if he misses a significant number of games, the Dodgers have a smaller chance at making the playoffs; and if they don't make the playoffs, many of those fans and bandwagon jumpers going to games and buying Greinke jerseys will go away, costing the franchise money.
So although the way in which Greinke got hurt wasn't silly, Quentin's actions certainly were. Maybe this will be a lesson to other teams. Let's just hope the MLB punishes the Padres and Quentin accordingly, for possibly altering the Dodgers' entire 2013 campaign.


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In To Kill a Mockingbird, prove that Jem Finch is either mature or brave.Use quotes if possible.
- print Print
- list Cite
As you look at the concept of characterization in Jem Finch, I think you could actually use the idea that his bravery proves he has become more mature.
Look at the change in Jem from the beginning of the book to chapter 28. At the beginning of the story, Jem is the propagator of Boo Radley as a "haint," or "ghost." He is the one who teaches Scout and Dill about "hot steams." One of the clearest indicators at the beginning of the story, however, of Jem's immaturity, comes in chapter 6 when he goes to the Radley place to get a glimpse of Boo at night. When Scout is apprehensive he is exasperated with her:
I declare to the Lord you're gettin' more like a girl every day!
By the end of the story, however, Jem's sense of maturity displays itself in the form of bravery and protection of his sister. As the two walk home alone from the school pageant at night, Jem hears something rustling behind them. Scout, positive Jem is just trying to scare her, attempts to call his bluff. She knows he is serious, however, with this:
"Be quiet," he said, and I knew he was not joking.
Within one year, Jem has gone from an immature boy who tells ghost stories to trick and scare the little sister who annoys him. By the end of the story, however, he is brave enough in the face of real danger to protect her. The rest of this climactic scene, as you know, includes Jem fighting with the unknown attacker and telling Scout to run. His bravery here directly proves his maturity.


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What role does the Harlem Resnaissance have in F. Scott Fitzgerald's The Great Gatsby?
- print Print
- list Cite
America was rapidly changing in the 1920's, and that rapid change was not simply limited to the white community. In the aftermath of the Civil War, things were not exactly ideal for African-Americans, but over time a culture of fine arts began to develop in the form of jazz music, literature, and poetry. The work of Duke Ellington (music), and Langston Hughes (poetry) are a couple of the more well-known artists of this period, but there were many more. Tom Buchanan alludes to the changing role of African-Americans a couple of times in the novel. Early in the story, he mentions the need of the "dominant race" to keep things in order and under control; later, during an argument with Gatsby over Daisy, Tom invokes the idea of the decline of family life and family institutions (ironic in and of itself since he is an adulterer) and likens it to an interracial marriage that will destroy society itself.


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Lundby 3/4" scale furniture was manufactured in Sweden during the 1970's and 1980's.The pieces are manufactured from hard wood.
I have had these pieces for a couple of years now, just sitting in a clear plastic box staring at me. I have watched Lundby furniture and houses on eBay. There seems to be quite a following.
The couch and two chairs are part of the living room set, while the corner hutch is actually part of the dining room set. I do not know the manufacturer of the table and chest of drawers, but it seems to be the correct scale.
I said goodbye to these pieces and sold them on eBay this week. My hope is that the person in California who won the auction will be able to have fun with them!


text: Hi ladies and gentlemen. I went to the salon today and my stylist showed me a book called Curly Girl by Lorraine Massey/Deborah Chiel and in it was a recipe for lavender hair mist that my stylist used on me and recommended. It smells so incredible and is easy to make if any of you are interested. I just made it tonight so I can't wait to try it. I'm sure it is fine for straight hair, too! Anyway, here is the recipe: [SIZE=-1]"Lavender has cleansing properties, so this quick mist not only makes your hair smell like a lavender field in Provence, it's also indispensable for cleansing and reviving your curls. Make it in large quantities; keep a large spray bottle in your shower and smaller travel-size bottles in your purse, desk, and car.[/SIZE] [SIZE=-1]1/2 gallon water 5 drops pure (not synthetic) lavender essential oil 3 empty spray bottles (available at most drugstores)[/SIZE] [SIZE=-1]1. Fill a large pot with a half gallon of water. 2. Cover, bring to a boil, and simmer for an hour to get rid of impurities. (Check occasionally to make sure water isn't boiling away.) 3. Remove from heat, add lavender oil, stir, and replace lid. 4. Let steep until cool, then pour into empty spritz bottles." [/SIZE] [SIZE=-1]I cut the recipe in half because I won't use 3 bottles so I will have to see how it works and let you know. [/SIZE]


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Jennifer Evans Kramer eBooks
eBooks found: 1
Ocean Hide and Seek
Jennifer Evans Kramer & Gary R. Phillips
Sylvan Dell Publishing, March 2009
Format: PDF
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The New York Times: purveyor of "All The News That's Fit To Print." And now, all the news that's fit to stream too?
A Nieman Lab reports, The Times has struck a licensing agreement with Hulu, making some of its video content available through the popular online streaming service. For the moment, the only Times video that is on offer with Hulu is a documentary about hockey named "Punched Out: The Life and Death of an N.H.L. Enforcer," but Nieman Lab writes that more content is due to be uploaded soon.
Author of the article Justin Ellis suggests that putting content on Hulu has both pros and cons for the Times. "On Hulu, a viewer may be more likely to seek a lean-back entertainment and watch a video longer than five minutes," writes Ellis, "But by putting the videos on Hulu, the Times is also sending eyeballs off their property and adding an intermediary who'll expect a cut of the ad revenue."
Nevertheless, even with these extra charges, there's big money to be made from online video, as the Times itself has pointed out. In an article published last February, the paper noted that video content commands particularly high advertising revenues: for video ads, advertisers can pay $20 - $50 per thousand views. Video ad spending is expected to be more that $3 billion this year, rising from $2.16 billion last year. Ken Doctor writes it is expected to rise to $7.15 billion in 2015. These numbers make it the fastest–growing type of digital ad spending.
The Times, like many other organisations, is vying for a slice of the pie. Speaking at WAN-IFRA's Digital Media Europe event in London in April, Chairman, CEO and Publisher of the New York Times Company Arthur O. Sulzberger, Jr said that video was one of the four key areas that the Times would be focusing on for future growth. He said the Times aims to create video content that "inspires the same interest, trust and loyalty" as the rest of its journalism.
A major competitor in the field is the Huffington Post, which announced in February that it would be launching its own live video network, which would "combine broadcast news with social media." Capital New York gave an update on the new network's progress last week: it will be known as HuffPost Live, it is set to launch at the beginning of July and aims to produce 12 hours of live video content every weekday, with the help of more than 100 staff.
According to Capital New York, the Huffington Post's founding editor Roy Sekoff has stressed that HuffPost Live is not planning to compete with traditional broadcasters like CNN or MSNBC. Instead, it will focus all its efforts on promoting audience engagement. "People don't want to be talked to. They want to be talked with," Sekoff told The New York Times in February.
The Wall Street Journal is also a big player in the live video streaming field. WSJ Live, launched in September 2011, won big praise from media analyst Ken Doctor, who called it a "milestone product" and a "model for the news industry." As Doctor explains, WSJ Live offers both scheduled programming and on-demand content, and its format is well adapted to tablet and mobile platforms. As Nieman points out, the Journal is also already on Hulu. What's more, The New York Times has quoted Alan Murray, Executive Editor of wsj.com, who says that video attracts "the highest C.P.M.'s of anything we do."
The many examples point to the same trend: video content can mean big audiences and big money for news organisations that started out based in text. The challenge now is to work out the best way to get in the game.
Sources: Nieman Lab (1) (2), New York Times, Huffington Post, Capital New York, Editors Weblog


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APM Terminals operates a Global Terminal Network which includes 20,300 employees in 67 countries with interests in 72 port and terminal facilities and over 160 Inland Services operations. In 2013, APM Terminals was named "International Terminal Operator of the Year" by Containerisation International for the second consecutive year. They were also selected as the winner of the "Port Operator Award" at the Lloyd's List Asia Awards.
APM Terminals has opened its new terminal on Maasvlakte II and this terminal has set a new global standard in automated and environmentally sustainable terminal operations. A 'game-changer' within the shipping industry that marks a new era in port innovation. The partnership between ECE & APM Terminals Maasvlakte II supports this focus on innovation within the harbour sector.
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Featured property
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Oasis in hayes if its peace and quiet your after then this one bedroom apartment has it. tucked away at the end of the road is this neat and tidy block of apartments. surrounded by…
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Road King is the first Asian high yield name to sell investors a fixed for life deal, said syndicate bankers on the transaction. A fixed for life trade does not offer a guaranteed step-up and plays to the issuer's advantage.In this case, the issuer will only offer ...
Please take a trial or subscribe to access this content.
Contact our subscriptions team to discuss your access: email@example.com
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To discuss GlobalCapital access for your entire department or company please contact our subscriptions sales team at: firstname.lastname@example.com or find out more online here.


text:
Twiflex Ltd., a supplier of brakes and clutches to the marine industry, said it will launch its new TLB (Turning, Locking and Braking) system at WorkBoat International, November 30 to December 2, 2016 in New Orleans. Originally designed in-house by Twiflex…
read more
Scania introduces a new range of marine propulsion units consisting of engine, transmission and type-approved instrumentation at the International Workboat Show in New Orleans, Louisiana.
SSI's latest release, ShipConstructor 2016 R2 will be unveiled for the first time in public at the International WorkBoat Show, December 1-3, in New Orleans. According to SSI,
MagnaShear Marine Duty Motor Brakes Provide a Maintenance-Free Solution for Frequent Start/Stop Cycles for Onboard and Port-side Cranes The MagnaShear marine
Rolls-Royce will showcase its latest marine power innovations, including several MTU commercial marine products and systems, at the International Workboat Show 2015, December 1-3 in New Orleans.
Manufacturer of technologically advanced industrial and marine braking systems Dellner Brakes AB has launched what it is calling "the world's first fully automated, electrical 'Stop, Turn, Lock' (eSTL) braking system" at September's...


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Traveling Luck for Lake Shore Drive Picnic Area, Illinois, United States
Where is Lake Shore Drive Picnic Area?What's around Lake Shore Drive Picnic Area?
Wikipedia near Lake Shore Drive Picnic Area
Where to stay near Lake Shore Drive Picnic Area
The timezone in Lake Shore Drive Picnic Area is America/Rankin_Inlet
Sunrise at 07:08 and Sunset at 17:11. It's Dark
Latitude. 37.7833°, Longitude. -89.3811°
Weather near Lake Shore Drive Picnic Area; Report from Carbondale / Murphysboro, Southern Illinois Airport, IL 15.2km away
Weather :
Temperature: 4°C / 39°F
Wind: 11.5km/h West/Southwest gusting to 25.3km/h
Cloud: Broken at 4200ft Solid Overcast at 5000ft
Weather :
Temperature: 4°C / 39°F
Wind: 11.5km/h West/Southwest gusting to 25.3km/h
Cloud: Broken at 4200ft Solid Overcast at 5000ft
Satellite map around Lake Shore Drive Picnic Area
Loading map of Lake Shore Drive Picnic Area and it's surroudings
Geographic features & Photographs around Lake Shore Drive Picnic Area, in Illinois, United States
- school;
- building(s) where instruction in one or more branches of knowledge takes place.
- Longfellow School (4.3km)
- Murphysboro Township High School (historical) (4.4km)
- Murphysboro Middle School (4.4km)
- Carruthers Elementary School (4.7km)
- Immanuel Lutheran School (4.7km)
- Lincoln Elementary School (4.9km)
- Logan Elementary School (5.1km)
- Worthen School (5.1km)
- McElvain Elementary School (5.6km)
- Saint Andrews School (6km)
- Douglas School (6km)
- Washington School (6.3km)
- Pond School (7.3km)
- Local Feature;
- A Nearby feature worthy of being marked on a map..
- Lake Shore Drive Picnic Area (0km)
- Oak Point Picnic Area (0.4km)
- Shady Rest Campground (0.6km)
- Big Oak Campground (0.6km)
- Pine Circle Picnic Area (0.6km)
- Clear View Picnic Area (1km)
- Water Lily Campground (1km)
- Shady Cove Picnic Area (1km)
- Hickory Grove Picnic Area (1.2km)
- Bald Knob Picnic Area (1.2km)
- Mount Pleasant Station (historical) (3.3km)
- Saint Peters United Church of Christ (5.3km)
- Buttermilk Hill Beach and Picnic Area (6.6km)
- cemetery;
- a burial place or ground.
- Tower Grove Cemetery (2.8km)
- Saint Andrews Cemetery (3.1km)
- Boucher Cemetery (4.5km)
- Worthen Cemetery (4.5km)
- Ripley Cemetery (4.9km)
- Murphysboro City Cemetery (5.1km)
- church;
- a building for public Christian worship.
- Mount Joy Church (2.4km)
- First Presbyterian Church (4.5km)
- Liberty Street Baptist Church (4.6km)
- Saint Andrews Catholic Church (6km)
- Pate Chapel Baptist Church (6.4km)
- park;
- an area, often of forested land, maintained as a place of beauty, or for recreation.
- Lake Murphysboro State Park (0.1km)
- Glenn Schlimpert Recreation Area (3.9km)
- Riverside Park (4.6km)
- Paul Ice Recreation Area (4.8km)
Accommodation around Lake Shore Drive Picnic Area
- populated place;
- a city, town, village, or other agglomeration of buildings where people live and work.
- Harrison (5.1km)
- Murphysboro (5.6km)
- Texas Junction (7.1km)
- reservoir(s);
- an artificial pond or lake.
- Lake Murphysboro (1.4km)
- Borgsmiller Lake (3.8km)
- Borgsmiller Lake (6.6km)
- stream;
- a body of running water moving to a lower level in a channel on land.
- Jones Quarry Creek (4.3km)
- Lewis Creek (6.1km)
- Kinkaid Creek (7.7km)
- administrative division;
- an administrative division of a country, undifferentiated as to administrative level.
- Levan, Township of (7.1km)
- Somerset, Township of (7.3km)
- building(s);
- a structure built for permanent use, as a house, factory, etc..
- Jackson County Courthouse (5.7km)
- Levan Townhall (6.3km)
- lake;
- a large inland body of standing water.
- Browns Lake (5.7km)
- Carbon Lake (6.5km)
- airport;
- a place where aircraft regularly land and take off, with runways, navigational aids, and major facilities for the commercial handling of passengers and cargo.
- hospital;
- a building in which sick or injured, especially those confined to bed, are medically treated.
- Saint Joseph Memorial Hospital (6.2km)
- post office;
- a public building in which mail is received, sorted and distributed.
- Murphysboro Post Office (5.5km)
- dam;
- a barrier constructed across a stream to impound water.
- Borgsmiller Lake Dam (6.6km)
- second-order administrative division;
- a subdivision of a first-order administrative division.
- Jackson County (4.1km)
Wikipedia entries close to
Lake Shore Drive Picnic Area
- Murphysboro, Illinois city city o
- Southern Illinois Airport airport airport
- Gorham, Illinois city city o
- Vergennes, Illinois city city o
- De Soto, Illinois city city o
- Carbondale, Illinois city city o
- Ava, Illinois city city o
- Elkville, Illinois city city o
- Grand Tower Pipeline Bridge landmark bridge
- Grand Tower, Illinois city city o
- Dowell, Illinois city city o
- Hurst, Illinois city city o
- Campbell Hill, Illinois city city o
- Makanda, Illinois city city o
- Bush, Illinois city city o
- Cambria, Illinois city city o
Airports close to Lake Shore Drive Picnic Area
Scott afb midamerica(BLV), Belleville, Usa (114.8km)
Lambert st louis international(STL), St. louis, Usa (168.2km)


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9 Questions with E. J. Shumak
E. J. Shumak lives in metro Chicago, Illinois, and has spent most of his life in northern Illinois and southern Wisconsin. He has been many things, police officer, large cat sanctuary operator, C.P.A. and on again, off again writer. He holds membership in S.F.W.A. He has published four books, along with several dozen short science fiction pieces and non-fiction articles. He has extensively used his experiences as a sanctuary operator in the 80's and 90's to fuel his writing.
1. How long have you been writing and what got you started?
I started writing in the 90's with some animal based non-fiction and search and seizure law articles. I caught the SF bug — I always loved speculative fiction and I did well for a while, earning SFWA membership. Then life interfered even more. I lay dormant for nearly 20 years and have now reawakened.
2. What is the best piece of advice you have for new writers?
The most important thing is write and write what you love. If you can find a good workshop group — it will make your life much easier.
3. Are there any writing resources, such as books or websites, you'd like to recommend?
A good writers group — But be careful — it is your story NEVER write by committee.
4. What is your favorite type of fiction and who are your favorite?
I love most speculative fiction, specially galaxy spanning Hard SF. My favorite authors are Hemingway, Asimov, CJ Cherryh and I am always excited to read a new writer who grabs me.
5. What tips do you have for finding time to write?
One has to want to and need to write. If it is difficult to find time, you will if you truly need to write. If not, perhaps a break is in order — I took a 20 year break. So I am no one who can complain.
6. How do you deal with rejections?
I use it as an excuse to rewrite and look over my piece. Or if I am sure the piece is right for me, I simply send it out to the next editor until I find one who agrees with me.
7. What are your writing goals for the next twelve months?
I hope to empty out my cache of twenty year old stories. And KEEP WRITING
8. For the next five years?
Finish my novel and get it sold, then get started on the next one.
9. Is there anything you'd like to plug? Feel free to share a link.
Yes, thank you, just two links. First, my Google Plus page: google.com/+EJSHUMAK And my Amazon Author's page http://www.amazon.com/E.J.-Shumak/e/B00V6H1T4W/ref=sr_tc_2_0?qid=1428676931&sr=1-2-ent