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Jim Kelly got a second chance at life. Maybe even a third chance and he's going to fulfill it by making not about himself, but for others.
The Hall of Fame quarterback for Buffalo Bills during the John Elway quarterback era, Kelly was in Denver on Friday to make cancer victims aware of his all-encompassing Your Cancer Game Plan organization.
His trip in was well-timed as six days earlier, the Denver Broncos selected his nephew, Ole Miss quarterback Chad Kelly, with the No. 253 and final pick of the NFL Draft.
"If he comes back healthy, watch out,'' Jim Kelly said. "Because he's a heckuva quarterback.''
As prospects go, Chad Kelly for the longest time was like an untamed colt who took a while to break. There were off-field skirmishes, including one that landed him briefly in jail. Elway, who is now the Broncos' general manager, called his former colleague and fellow 1983 draft pick to ask about his nephew before drafting him.
"Bottom line is, those things happened three years ago,'' Kelly said in an interview with 9NEWS. "People keep bringing that up and as an uncle and he's my godson, it irritates me because he's a good kid.
"And, yeah, he made stupid mistakes. But that was three years ago and they keep bringing it up. Most of those things happened when he was not even at Ole Miss and people keep bringing it up.
"But you know … he's learned from it and hopefully he continues to learn, like all kids do. But he's a guy, his work ethic is unmatched. I never even came close to his work ethic. His athletic ability. Now he has to get healthy.''
Jim Kelly said Chad Kelly's recovery from his second ACL surgery is about 80 to 85 percent along. A bigger issue, at least for the short term, is Chad Kelly recently had surgery on his right wrist that will knock him out for a while.
Not that Elway wants Chad Kelly wants to lose all his fighting spirit. Look at the players Elway has added to the Broncos' roster the last year or three. They all have an attitude, a spirit about them. Elway likes Chad Kelly in part because he is a player with gumption.
"That's the way John was, too,'' Kelly said, laughing. "And myself and (Dan) Marino and the thing is you've got have that little chip on your shoulder, which there's no doubt he has on his now because of all the teams that shunned him and didn't pick him.
"But you've got to understand there's going to be a question mark when you have your knee and you have your wrist surgery.
"But I look forward to it. I look forward to cheering him on. He's got two guys in front of him he can learn from (Trevor Siemian and Paxton Lynch) and hopefully – who knows what the future holds, but I have a lot of confidence in the kid. He's a baller. He's a player. Just keep my fingers crossed and keep praying.''
Long term, the bigger concern for Chad Kelly is he's had double ACL surgeries. One in the spring of 2013 – in which he returned to the field five months later – and the other in the fall of 2016.
The list of players making a successful comeback from one ACL surgery gets longer every year. The list of those returning from two ACL surgeries is written in gray, not black and white.
"He's a quarterback,'' Jim Kelly said. "He'll wear a knee brace. He won't be able to scramble the way he used to. But a lot of times you look at all the great quarterbacks in the league today, most of the great ones are pocket passers.
"Yeah, you want a guy who can get a couple first downs with his legs, which I still think he'll be able to do. But he won't be the Chad Kelly with the running ability he used to have. But now it's all up in your head. It's being able to read the defense and your hot routes and be a quarterback in the NFL. It's not college any more. I have faith in him.''
Forgive, Jim Kelly for downplaying the long-term effects of double ACL surgeries. Jim Kelly came back from double cancer in his upper jaw.
He was first diagnosed with squamous cell carcinoma in 2013. Surgery removed his upper jaw and V2 nerve and rebuilt it. He was proclaimed cancer-free. In March of 2014, his cancer returned.
The news hit as the NFL owners were convening in Florida. NFL executives and coaches asked for a reaction to Kelly's condition may not have quite talked about him in the past tense. But put it this way: Nobody thought then he would be sitting in a chair for a 9NEWSinterview three years later.
"A lot of people didn't, but I did,'' Kelly said. "What I'm learning through my whole journey, not just through my cancer that I'm going through now, but even way back when I tore my shoulder (the third game of his senior year at the University of Miami) and they told me I'd never play football again. And going to four Super Bowls and not winning and having a son (Hunter) born on my birthday and he winds up passing away, and all the things I've been through, I never thought that cancer would come into my family. And all the sudden, boom, it hit me, not just once, but twice.
"And laying there in a hospital room in New York City and giving me less than 10 percent chance of making it – which thank God they did not tell me. They did not tell my family because it's all about your attitude. I've learned throughout my whole life, it is about your attitude to continue to get you through, to keep fighting and never give up.''
The shoulder separation in his senior season at Miami nearly ended Kelly's professional quarterback career before it started. He eventually ushered the NFL into a no-huddle, wide-open, point-scoring frenzy through the Bills' 'K-Gun'' offense. But four Super Bowl appearances in four years left him and the Bills with zero Lombardi trophies.
Shortly after Hunter's birth on Feb. 14, 1997, he was diagnosed with Krabbe Disease, a degenerative disorder of the nervous system. Hunter courageously fought to live much longer than expected before dying from the disease at 8 years old.
And then Jim was hit with cancer at 53 years old. No doubt, Kelly has had his share of tough breaks.
"I laugh about it, too,'' Kelly said.
Only he doesn't seem to look at it that way.
"You do to a certain point because you always look back and say the good Lord had a plan for me,'' he said. "And I know I went through a lot, I've been through a lot. I've been at the top of the hill and I've been to the bottom.
"It's the people you surround yourself with. I've been very blessed to have a great team. Even the team I have now with 'Your Cancer Game Plan.' It's to go out there and encourage people to never give up. And we do have a place you can go to, log on to yourcancergameplan.com. There's so many questions people have. And I remember when we were going through it, I had nowhere to turn. My wife didn't know who to talk to.''
And now the inflection in Kelly's voice raises as he gets to the cause that is now part of his life's work.
"Head and neck cancer, over 60,000 people this year will be diagnosed with head and neck cancer,'' he said. "All the sudden we came up with this Game Plan. I'm glad that we know more now so we can tell more people about it to make a difference in their lives.''
Nearly everyone reading this has the experience of loved ones whose lives have been affected by cancer. One of the first questions people have is: How did they get it?
"People thought I either dipped or smoked,'' Kelly said. "I've never dipped in my life and I've never smoked a cigarette in my life. I've had a few cigars here and there, you know, by the campfire in celebration. But I just thought that I had some bad teeth. So I had a number of root canals done. But the pain was still so severe in my head that I knew something was wrong.''
He had two biopsies. The first came back negative. Kelly knew better than to celebrate. The pain was still there. Something was wrong. A second biopsy revealed what doctors diagnosed as squamous cell carcinoma. Surgery removed it once.
"And then it returned with vengeance,'' Kelly said. "That's when I went through my radiation and chemo. That's when it did not look very good for me. But the thing is I surrounded myself with quality people.
"I live by the four Fs. No. 1 is my faith. There is no doubt the prayers got me through to where I'm at today. No. 2 is my family. Not one time did they ever walk into my room whether it was my wife, my two daughters or my five brothers, they walked in with an attitude that they're going to make my day better. And they did.
"No. 3 was my friends. I'm blessed to have some great, great friends. And No. 4 is the fans. Believe it or not, New York Jets, Miami Dolphins and even Denver Broncos people were e-mailing me and sending me cards saying they're praying for me. And I'm like, 'Wow, is this really happening?'
"But I think that's why I'm put in a position today to be able to make a difference for others that don't have that supporting cast that I have.''
Kelly's website also lists proper nutrition as a critical factor to beating cancer.
"I was one of those guys, I'd eat everything you put in front of me,'' he said. "That's why I ballooned to 260 pounds.''
What was playing weight?
"Two, thirty, 232, right where I'm at right now,'' he said. "And then it's the attitude that you have. Never give up.''


text:
I went to prom with a guy friend I've had for two years. We've gone on casual dates and stuff but nothing serious. After prom he dropped me off and I could tell he wanted to kiss me but wouldn't have the guys to do it. I ended up giving him a casual kiss goodbye but now I feel like I was just doing him a favor and totally wasted my first kiss experience. Is it dumb to regret it?
Most Helpful Guy
For one thing there's no point in regretting it because there's no taking it back... And even if you were to have waited until your older there's no guarantee that, that moment would be a better one. I.e. I don't regret losing my virginity when I did, because the person was a lovely girl and it felt right at the time, we did break up in the end... But even if I waited until marriage what would stop me losing it then and getting divorced later down the line? Absolutely nothing, I know we all wish we could meet someone and that'd be it... But that's rarely ever the case.00|00|0

subset: commoncrawl


text:
On Tuesday, December 2, Students Supporting Israel at Indian University passed a resolution in its student government that adopts the United States' State Department's Definition of Anti-Semitism.
The Jewish Telegraphic Agency reported that the resolution passed at the Student Association Congress meeting by a vote of 22-6, with six abstentions.
The resolution states that, "the Indiana University Student Association adopts the definition of anti-Semitism as stated above as well as the State Department's understanding of Anti-Semitism relative to Israel" The Indiana University Student Association commented, stating they recognize "that the Jewish people, like all peoples, have a collective right to self-determination, and considers attempts to undermine these rights, including the global BDS Movement against Israel, to be a form of bigotry"
It also cites the Marcus Policy, initiated by LDB President Kenneth L. Marcus in 2004 during his tenure at the Department of Justice's Office of Civil Rights. This policy extended Title VI of the Civil Rights Act of 1964, which protects students from discrimination based on their race, color, or national origin at federally funded post-secondary educational institutions, to protect Jewish students based on their ethnic or ancestral background.
StandWithUs as well as Indiana Hillel helped the Students Supporting Israel to draft the statement.
The College Fix reported that the "revised version of the resolution distinguishes between the boycott, divestment and sanctions (BDS) movement and those individuals who support it, saying the student government frowns upon "the political platform" of BDS. It also makes explicit that "political criticism of Israel" is allowed.
Similar resolutions have been adopted by the University of California campuses in Los Angeles, Berkeley and Santa Barbara, in addition to the University of Minnesota, University of Georgia, Texas A&M, University of Nevada.


text:
An introductory piece of theatre dressed up as a cookery lesson for classes of 20-30 students to get them thinking about the importance of washing your hands with soap before preparing food.
The Change Agents should arrive at the school and ask permission to set up a food preparation area in a suitably clean area, probably outside (e.g., in playground).
The students should then be invited to attend to watch this slightly slapstick MODERN COOKERY LESSON.
They will learn about an important new ingredient that is making such a difference to cooking around the country – and at the end they will get to try the new dish.
If the Change Agents are male they can add to the entertainment by dressing up as female chefs and creating serious rivalry between their two efforts.
One of the Change Agents comes out from the toilet, and then asks to shake hands with the children in front.
Both set out their utensils and bowls of ingredients. They both have a bowl of water to wash their hands in as well.
The Lesson begins.
They wash their hands. But only one of the Change Agents uses soap.
The other one refuses the offer of soap and just uses water. He boasts about not needing soap. They argue but he won't listen. The children might even join in the argument.
The Change Agents who has used soap, proceeds to make a fine meal with typical local ingredients.
He holds up each ingredient and asks the children to identify it. He also tells a variety of jokes as he 'cooks' and also asks simple hygiene questions, which the children must answer before he adds the next ingredient.
The Agent who didn't use soap reveals a very different set of ingredients.
Dust, dirt, mud, dead flies, greasy water....contaminated hands have transformed the ingredients into the most impure and disgusting items.
He talks lovingly about the horrible ingredients he is using – even holding them up each in turn and asking the children to identify them.
When the dirty mud balls are finished he sets them out very carefully on a tray.
At the end of the lesson, students are asked to choose which side of the line they want to queue up on to receive the finished food.
When the audience clearly prefers the food prepared by the Change Agents with soap-washed hands, the other Change Agent should try to grab them with his contaminated hands, threatening to spread the infection and disgust even further. His hands are diverted away.
The dirty chef is offered a bowl of water and soap to wash his hands then invited to join the rest of the audience eating the clean rice balls.
Through this action he has been allowed to join the rest of the enlightened 'Choose Soap' group.


text:
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text: Interior Design is a vital part of our comprehensive services. From initial space planning to final selection of artwork and accessories, we can create a total interior environment. Interior Design services are offered individually or comprehensively, as you require. Our Interior Designers offer a unique viewpoint to design by understanding a space and how it is used. Our Interior Designers encourage dialogue with our clients to better understand their changing needs and what kinds of solutions we offer.


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The Blacklist: Conspiracy + Mod – Black List Android mobile arcade games and super criminal data
The regular version + mode version (Money / Hints / Anti ban) separately
The game always needs Internet
The Blacklist: Conspiracy – Black List: conspiracy new game in the genre of adventure games company Gameloft raised and the famous criminal for devices on Android for a few hours before Google was released for free in large supermarkets and again, as always, decided for the first your presence in Iran to introduce new game lovers! NBC series The Blacklist made since 2013 and continues to date is the main role of Raymond Rdyngtvn film, which has already been under investigation is one of the great villains are suddenly decided to surrender to the police the arrest helps his friends, but also the blacklist puzzle game from the series, all characters in the film is in its place and here you should not already rejected the role! In this puzzle game you have to find lost objects and solve different riddles steps, you get the questioning suspects and clues to analyze. With the passage of each level you'll get more ability to help you come that way! The graphics in this game, like the rest of the company's open Loft does not allow nothing to say!
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Staying Christian at the University
Does going to a secular college drive students away from Christian faith? According to one study, the answer is a solid "No." See FactChecker: Does College Cause Young Adults to Lose Their Faith? on The Gospel Coalition blog.
Among recently surveyed college students, 2.7 times more report that their religious beliefs have strengthened during their college experience than say their beliefs weakened.
My own faith was greatly strengthened as I went through college and graduate school, and I know a number of people who had the same experience. The Gospel Coalition article gives three potential reasons why many students have their faith strengthened while at secular colleges and universities:
1) The increase in presence and effectiveness of campus-based ministries like Campus Crusade, InterVarsity, and Young Life.
2) The increase of relativism and the decline of strict scientism, which allows for discussion of faith and spiritual speculation, similar to what Paul experienced at the Aeropagus.
3) An increase in committed evangelical and Catholic faculty at secular universities in America who can serve as an encouragement and balance for Christian students.
I would suggest a fourth reason: Christian students at secular universities have interacted with non-Christians and their ideas, and have had to work through issues in the real world rather than in the insulated environment of a Christian university. For many Christian students, facing these challenges has strengthened their faith.
I am curious as to how Christian students who attend secular universities compare in the long run to those who attend rigidly young-Earth schools, such as those listed on Answers in Genesis' Creation Colleges page.
Grace and Peace
HT: Cranach
P.S. One of my children graduated from a fine Christian college a year ago (Trinity Western University in Langley, British Columbia), and has a good foundation for a lifetime of faith and service. Two of my children are currently attending a state university, and are growing in their Christian faith in many ways that didn't occur in the home or in youth group in high school. Both are active in InterVarsity Christian Fellowship.
Around the web 7/13/2013 — No response on salt magma hypothesis, nature deficit disorder, thou shalt not criticize Ken Ham, and more
It has been a while time since my last "Around the web" post, and I have bookmarked more articles than I can reasonably make brief comments on. Here are a few…
THE DEATH OF GOOGLE READER — Since the untimely demise of Google Reader a couple weeks ago, I haven't been keeping up on the fifty or so blogs I followed somewhat regularly. Somehow I have survived. I will have to choose a new RSS agreggator. Any suggestions for one that works somewhat like Google Reader did?
SEASONED WITH SALT — A few months ago I blogged about the latest failed young-Earth creationist attempt to explain evaporite deposits (such as halite, or rock salt): A young-Earth creationist magmatic model for the origin of evaporites. This "salt magma" hypothesis was being promoted on Tas Walker's Biblical Geology Blog. I was hoping for some sort of response from the YECs, so I placed a comment on Walker's blog post:
It has been almost two months, so either my critique was devastating and unanswerable, or not even worthy of a response. Or Tas might just have gotten behind on his blog responses, which I have been guilty of far too often.
NATURE DEFICIT DISORDER — Anyone who cares about the environment should be concerned about what author Richard Louv called the "nature-deficit disorder" in his 2008 book Last Child in the Woods. Al Mohler has a good summary of the book: Nature Deficit Disorder — Is Your Child at Risk? Mohler concludes with:
Last Child in the Woods is a fascinating book, though at times, Louv leans toward a form of nature mysticism. Nevertheless, Christians will read this book to great profit, remembering that the biblical worldview presents an affirmation of the goodness of creation. After all, Christians know that every atom and molecule of creation testifies of the glory of God.
This is our Father's world, and we would do well to receive this world and enjoy it, while giving praise and glory to God for the beauty and bounty it contains. We understand that nature is not an end to itself, and we affirm that the creation exists as the theater of God's glory for the drama of redemption. All this should help Christians to remember that we honor God most faithfully when we receive His good gifts most gratefully.
Christians should take the lead in reconnecting with nature and disconnecting from machines. Taking the kids for a long walk in the woods would be a great start.
KEN HAM AND SONLIGHT CURRICULUM — We homeschooled our children in their early elementary years, and used a lot of material from the excellent company Sonlight Curriculum. A co-founder of Sonlight had the nerve to criticize Answers in Genesis president Ken Ham for his if-you-don't-agree-with-Ham-you-are-a-compromiser approach to Christian ministry. I guess he didn't know that Thou Shalt Not Criticize Ken Ham.
John Holzmann of Sonlight: The conservative (evangelical/fundamentalist) Christian homeschool pope
Ken Ham: Cofounder of Sonlight Calls me "Pope Ham"
John Holzman has apologized to Ken Ham for using the phrase "Pope Ham." I would like to see Ken Ham apologize for his divisive my-way-or-the-highway attitude that causes many of his followers to look at old-Earth Christians as compromisers at best and not Christians at all at the worst.
Even young-Earth Creationists who disagree with Ham incur his anger. See Ken Ham's Christian Leader Criticizes Creation Museum and Jay Wile's Upset Creationist.
CHRISTIANS SHOULD BE ENVIRONMENTALISTS — Matthew Tuininga at the Christian in America blog asks the question: Should Christians Be Environmentalists? The answer, of course, is "yes." But you would never know it from the anti-environmental political positions taken by many Christians and the politicians they support. Tuininga writes:
If there is any area in which a rapprochement would be for the benefit of all, this is it. Eliminating the left's grip on the environmental movement, and especially on government bureaucracies like the Environmental Protection Agency (EPA), would give it more credibility among the American public, and broaden its influence. It would mitigate the statist impulse that so often informs its political campaigns by encouraging the sort of market oriented strategies that often work best. It would curb conservatives' tendency to oppose environmental regulation in the name of free enterprise no matter how necessary that regulation in a particular case might be. In short, it would help liberals and conservatives alike to see that Christianity, care for the environment, and commitment to a free market economy need not be, and never should have been, rivals in a zero-sum game.
ZOOMING IN ON PLUTO — The New Horizons probe is still 550 million miles from Pluto, which it will fly by two years from tomorrow (on July 14, 2015), but its cameras are already aimed at the dwarf planet and its moons: NASA Spacecraft Photographs Pluto's Largest Moon Charon. I have been excited about this mission since it was launched in 2006, back when Pluto was still a planet.
A NATIONAL PARK ON THE MOON? — There is a proposal in Congress to create a National Historical Park on the moon to commemorate and protect the six Apollo landing sites: Moon Bill Would Create National Park to Protect Apollo Landing Sites. Given the historical significance of these sites, I think this is a good idea, even though the sites are not in the sovereign territories of the United States. However, given human nature, I predict that artifacts at these sites will be disturbed and/or stolen by the end of this century.
THE RAT ON MARS — In case you missed it, this may have been a bigger cover-up than the Face on Mars. NASA has completely ignored clear evidence of mammalian life on Mars: Curiosity Rover leaving 'Mars rat' behind.
NOT A GOOD TIME TO BE A CHRISTIAN IN THE MIDDLE EAST — For obvious reasons, Christians in countries such as Egypt and Syria tend to be wary of "Islamist" governments. The Islamist response tends to be rather harsh: Egypt's Christians face backlash for Morsi ouster.
Grace and Peace
Life beyond the granite tombstone
You may have been wondering, but I am still alive. I just haven't been blogging for awhile. More important things have been taking up my time, such as my son's wedding last week in British Columbia.
Some day, however, I will be dead. I'll be under a tombstone, providing nutrients for worms and soil bacteria. But as a Christian, I believe that my death will not be the end of my existence.
The Christian hope is for physical resurrection in a real body in a real physical realm—the New Earth. Just as Christ rose from the dead in glory with a real body—he ate real food and invited Thomas to touch his wounds—so also will we be given a new body that will be freed from the corruption that characterizes our current existence.
The biblical picture of the resurrection is not one of disembodied spirits floating in the clouds playing harps. This ethereal existence is what many people picture as "eternal life," but it is not found in the Bible. The Bible does not portray us going up to "heaven" as much as it paints a picture of heaven coming down to Earth. At that point, God's people will experience the oft-repeated Old Testament promise that "I will walk among you and will be your God, and you shall be my people" (Lev 26:12 ESV). I look forward to that day with joyful anticipation.
Jesus said to her, "I am the resurrection and the life. Whoever believes in me, though he die, yet shall he live, and everyone who lives and believes in me shall never die. — John 11:25-26 ESV
Then I saw a new heaven and a new earth, for the first heaven and the first earth had passed away, and the sea was no more. And I saw the holy city, new Jerusalem, coming down out of heaven from God, prepared as a bride adorned for her husband. And I heard a loud voice from the throne saying, "Behold, the dwelling place of God is with man. He will dwell with them, and they will be his people, and God himself will be with them as their God. He will wipe away every tear from their eyes, and death shall be no more, neither shall there be mourning, nor crying, nor pain anymore, for the former things have passed away." And he who was seated on the throne said, "Behold, I am making all things new." — Revelation 21:1-5 ESV
Grace and Peace


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There is a few mistakes, but you gotta love how real the picture is. She has zits, hair on her stomach, unmanicured hands...she's an everyday-too-busy-working-woman!
gotta love the way over sharpened eyes


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Hot For Teacher #3
Studio: Innocent HighCWMH
Series: Hot For Teacher
Approximate Running Time: 02:35:35
Released: 2012
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Have you ever thought your teacher was hot? Well these girls do and they want a chance to get a piece of them. Watch these coaches and professors take some time outside of the classroom to give their students that extra attention they need! After school activities is where these babes really shines! Starring Lexi Diamond and many more hotties giving you five great scenes of action!
Categories: Character -> Teachers Character -> Student Plot Oriented -> Contemporary Hardcore -> Sex Age -> Young Women / Teens Gonzo -> Teen


text:
A few weeks ago, after several months of half-assed planning, The BF and I trekked out to Connecticut for an evening with a few good friends. It had been decided way back in December that it would be absolutely necessary for me to learn some classic Israeli cooking from his friend Zig. It's an area I know absolutely nothing about and judging by the delicious smells of spices wafting out of Zig's fridge, I knew I had to learn. Chitlins, allow me to introduce to you one of the most awesome dishes I have had the courtesy of tasting, consuming and enjoying that actually {gasp!} involves fish.
Pick yourself up off the floor, I know that was a statement to rock anyone's world. The BF nearly went into throes of ecstasy when he saw me happily consuming the halibut on my plate. I mean he'd only been trying for two years to get me to like fish, and suddenly it had happened.
Now, before you think I've gone and tossed all my sea creature prejudices you can just sit right back down and I'll fix that for you. I do not eat crustaceans, things that crawl on the ocean floor, have more than four legs, or the potential to eat me if it were to come to hand to hand combat. Also, if it smells like cat food, I'm out. You'll find that covers basically every category of seafood out there.
But Zig is a freakin' miracle worker. He prepared for us a fish dish that has been in his family for several generations, I do believe. One of those awesome dishes that has a secret ingredient! Can you believe it? Apparently all the great dishes with secret ingredients died out in my family, and so I have been desperately searching for one, and whaddyah know, it crept up in a fish dish.
Let me tell you something about Zig. The man is a walking encyclopedia…on tea. I think what I find the most hilarious when I visit his apartment, is that he has a mini wine refrigerator, but it's all packed with exotic and expensive teas. I mean, if it works, who am I to contradict it? He's traveled to China simply to search out the best tea regions. He has books, upon books of tea, and he's actually read them. He can recommend them to you based on what kind of knowledge you wish to gather. I actually have one right now, haven't read too much of it yet, but the pictures are pretty rad.
Here's another thing about Zig. He has "The Glass Man" disease. If you don't know what I'm talking about, maybe this will help. Remember that movie Unbreakable with Bruce Willis and Samuel L. Jackson, the one that came out a hot second after The Sixth Sense, so everyone was skeptical to see it because they seemed too similar in plot? Well I saw it, and you should too by the way because, hello, Samuel L. Jackson is the man and Bruce Willis is freakin' hot.
But Jackson's character has brittle bone disease, also called Lobstein syndrome. The wikipedia article has all the specifics but this is what you need to know: obviously if you're going to have a disease you want the badassest of them all, which can only be determined based upon whether Samuel L. Jackson portrays a character with your disease. Game over, tally the score.
Of course this made me incredibly paranoid to meet Zig the first time because I am the biggest klutz I know (remember that whole lack of proprioception thing?). The last thing I wanted was for me to trip, rebound of a wall and then shatter Zig. Believe me, if anyone was going to do it, it'd be me. Luckily, I have visited Zig on a number of occasions, sometimes even consumed alcohol on those occasions, and I have yet to break him. I think Zig's pretty relieved on that account, and I'm pretty proud of myself too.
But enough chatter, I know you're all on the edge of your seat waiting for this recipe. I don't have exact measurements, because all the best family recipes work like that, but I'll try my best.
*Just a Note: I suggest buying your spices super fresh at an Indian or Israeli market, it makes all the difference. Otherwise, try looking for good Spanish paprika (not smoked) it has a better flavor than the generic stuff.
The Best Fish Dish
Serves 4
4 large hunks of halibut, scales removed (you want them to look like little steaks)
coarse ground salt
1 head garlic, minced (about 2 heaping tbsp)
1 heaping tbsp cumin
2 heaping tbsp paprika
1 tsp ground cardamom seeds
chili powder to taste (or if you happen to have your own secret Israeli chili blend toss that in there)
about 2 cups water
Season both sides of the halibut with the salt. In a small bowl mix together the spices and garlic. Heat a large skillet over medium heat and warm some oil in it. Add the spices to the oil and cook until fragrant, about two minutes. You should have a nice thick, but viscous, paste. Ladle in the water, 1/4 cup at a time, stirring constantly between additions to create a kind of stew. You want it a little thin, but not too runny.
Bring the sauce to a nice gentle simmer. Add the halibut steaks to the sauce and ladle the sauce of the top of the steaks. Cover the pot and let simmer for about 10 minutes. Flip the steaks and cook for another 10 minutes or until cooked through and tender.
Serve with a large portion of sauce and bread for mopping up the extras.


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I Have Found My One True Love
Personal Stories, Advice, and Support 153 People
I Have.Does anyone know who it is???? ;) heheheheehhe
I finally found the one...i love you baby, you make me smile and laugh and helped me out with my struggle today. TheGoth20 i will always love you, when we first started talking i know i made you mad and there was a couple times that you wouldn't even talk to me. But, now after talking you have found a...
There is no happinessfor me. I cry tears of blood for you every single night. You, whom I'd swear to support and protect unconditionally. Even though you don't love me, I cannot deny how I feel. Even though I hate it, I cannot stop loving you. It's painful, not being with you, it have driven me mad...
panopticonett 22-25, M 1 Oct 23, 2015
thedemonschild6 18-21, F 1 Nov 29, 2015
My Knightso i have thought i found my one true love already but it was a lie he was only using me and i found out but i was still lost in the darkness when this beautiful brightness found his way to careful and nervous me he spoke to me with concern and kindness he asked about me he's...
wintergold 22-25, F 3 Aug 26, 2013
I have my true love for is beautiful,smart, funny, tomboyish, loves to hunt,fish, play volleyball, mudding, etc and she is the most perfect person for me and I love her so much
Tigerbentz 18-21, M 0 Nov 22, 2014
Is it wrong to finally express your feelings tosomeone that you have known all your life that you are in love with them?
psychologyLover08 26-30, F 1 Response 2 Nov 29, 2015
I Found Herand to my joy, she like me, had learned from books how to make a good relationship so we have been happily and trouble free married for many years now.
jimrich 70+, M 0 Feb 23, 2011
I have found him my true love Zachary95 I loveyou I know I have trouble expressing myself with you but I know you will love me no matter what we are going to prove that forever is more then a word. I can't wait to be with you I love you babe
JustMe289 22-25, F 4 Aug 19, 2015
I Thought I Did...She told me I was hers... and I believed strongly that she was mine. It made me feel complete. For once, I was satisfied with my life. I had someone to care for. I am deeply in love with this beautiful, caring and intelligent woman.She started to have doubts in our relationship...
It's been difficult. I have racked my brainabout the decisions I have recently made. I questioned my own sanity. See, My life with my ex was not bad at all. I was content, comfortable. I was ok with everything. It was my life and not bad. Not great, but not bad. Some like to say I threw away a good thing. I am selfish...
irishstone 46-50, M 3 Responses 4 Feb 15, 2015


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Most of you know I've become a big fan of high volume training for my back workouts (the same goes for legs). Back is the biggest upper body muscle group, not to mention your back is much more complex than say chest or arms. That being said, I believe your back needs more overall volume of sets and reps to reach your full potential and grow.
I used a variety of weight training techniques in this 27-set high volume back workout. I started out with multiple pyramid sets (8 sets total) on the first exercise, going up in weight every 2 sets. The reps started out at 15. As I went up in weight they dropped to about 8 on the last 2 sets. I also implemented the 10 x 10 technique followed by some rest-pause sets.
27 Set Back Workout
I didn't do a ton of exercises here for back, which is a little different than my usual back workouts. But as you can see I did multiple sets and techniques that gets you to the insane 27 total sets.
- Chest-Rest Rows: 8 sets x (15×2, 12×2, 10×2, 8×2)
- Lat Pulldowns: 10 sets x 10 reps
- Hammer Strength Rows: 3 rest-pause sets x (10, 7, 5 reps x 3)
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German Volume Training 10 x 10
The pyramid workout method is always a good way to get thoroughly warmed up and gradually get to moving some big weight. To me, it's a smart way to train. The 10 x 10 method is something I'll be using more of. It's part of the German Volume Training philosophy. This is a great way to add some serious muscle.
You can trace the German Volume Training method back to the early era of bodybuilders in the 60's and 70's (perhaps even before them). Guys like Arnold, Frank Columbu, Dave Draper, Lou Ferrigno, Frank Zane, etc. used high volume workouts to build top notch physiques.
Rest-Pause Sets for Back
I ended my high volume back workout with 3 rounds of rest-pause sets. This is hands down one of the most brutal weight training techniques. I do a set followed by a 7 second rest period then repeat twice. So 1 set is really 3 small sets. And you're not descreaing the weight (which is why the reps fall quickly).
Needless to say I was fatigued yet pumped after doing a total of 27 sets for my back workout. I also hit some barbell shrugs for traps and some calves at the end, followed by a 20 minute session on the bike. Some form of cardio is a must these days for me.
Train with Passion,


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text:
You might not realize it, but chances are pretty good that a melody is running through your mind right now. It may be something that you heard yesterday on the radio, it might be music that you downloaded from the Internet, it might be a catchy jingle from a television ad, or it might even be something that you composed yourself. As soon as you start humming, singing, or whistling, you are performing a melody. Melodies do more than just pass through our minds, though — they affect our entire bodies, causing us to tap our toes or move and dance without consciously thinking about it.
Technically speaking, melody is a group of notes that are played one at a time to a specific rhythm. These notes form a unit that we can recognize and remember. The melody is the part of the music that stands out as most important. It's what sticks in our minds once the music is over.
A melody is the musical equivalent of a sentence — it expresses a complete idea and it can be broken down into phrases. Sometimes these phrases sound like musical versions of questions with answers. The beginning of the melody may stop at a point without really sounding like it is finished. This phrase may sound like a question, or in musical terms an antecedent. The phrase that answers that question is called the consequent. The point of rest at the end of a phrase is called the cadence.
The smallest units of a melody are its notes or pitches. Pitch is the highness or lowness of a sound and its scientific term is frequency. Whenever we hear a sound we actually perceive vibrations of airwaves. Those airwaves can be measured in vibrations per second that we call frequency — the faster the vibrations, the higher the pitch. Most humans can hear a range of 20 vibrations per second to 20,000 vibrations per second.
Every melody has a tonality. The tonality is like a gravitational force in music. It draws our ears to one central pitch or tonic. Phrases that do not end on the tonic are the questions (antecedent), and they are answered by the phrases that end on tonic (consequent). Think of the melody to Mary Had a Little Lamb. With the words "Mary had a little lamb, little lamb, little lamb," we end the antecedent phrase. On the last "lamb" does it sound like the melody is complete? No, it doesn't. It is answered by "Mary had a little lamb, its fleece was white as snow." With the pitch for "snow" we end on tonic and complete the melody with its consequent phrase. This song is very simple and it is easy to hear each phrase. Although most melodies are more complicated than this one, they are usually constructed in a similar manner.
Each of the pitches of a melody has a specific length or duration. All of the durations in the melody create its rhythm. If the pitches did not have any set rhythm then the melody would consist of a bunch of notes that don't make much sense.
Melodies can be described in a few ways. The range refers to how high or low the pitches of the melody go. The contour of a melody is its shape and it describes the direction of the phrases. Melodies can also be analyzed by the distance between pitches. If the pitches are connected by step then they are close to one another. If they move by skip then there is some slight distance between them. And, if they move by leap then there is a large distance between the pitches.
For example, Mary Had a Little Lamb has a relatively narrow range. It does not go very high or low. Also, it moves almost exclusively by step. The song Happy Birthday has a wider range and moves by step and leap. Sing the melody and think about the distance between notes. "Happy birthday (leap) to you, happy birthday (bigger leap) to you, happy (really big leap) birthday dear person, (another big leap) happy birthday to you."


text: Puppy pads are poorly designed but until now were the only solution for allowing dogs the comfort of relieving themselves as needed. Now, there's a better option from the folks at Piddle Place™. Not meant to replace walking your pet, the Piddle Place™ dog toilet provides a comfortable sanitary environment for your pet to relieve themselves while waiting for your return or when weather permits a trip outdoors. It's perfect for house breaking, traveling with your pet on boats or RV's and condo living. Piddle Place™ is also great for the handicapped or elderly who find walking a pet three times a day a challenge. It's also good for cats!


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I love hearing from you and answering your career questions, and based on your e-mails and comments, I get the sense that you appreciate reading my career advice, too. Now you can receive my advice and the advice of several career experts through Twitter!
Sweet Careers has recently teamed up with CAREEREALISM and a diverse group of career experts for the Twitter Advice Project (a.k.a. T.A.P. into CAREEREALISM).
Here's a summary of how it works:
- You'll need a Twitter account to access this resource; you can sign up here. Remember to follow @careerealism and @sweetcareers.
- E-mail your career questions to email@example.com.
- Responses to your question will appear on the @careerealism Twitter feed.
(For more details about how T.A.P. works, and for a list of all the experts, check out CAREEREALISM.)
The Questions Answered segment at Sweet Careers is still available; find out more here.


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Pre-Order for 1/6 #Dorohedoro #Caiman from Threezero Begins Sept 30
[ More images HERE on FB ]
We've been seeing prototypes and the envelopment of this figure at shows and events where THREEZERO exhibits their works, and finally day the Hong Kong toy brand announces the upcoming pre-order for the 1/6th-caled CAIMAN, from "Dorohedoro" manga!
Pre-order begins 9:00AM Hong Kong Time via www.threezerostore on September 30th. Price for the Regular Edition is US$210 (price inclusive Worldwide Shipping), and I wouldn't be surprised if this version will be available via retailers eventually as well, so do check in with your favs…
[ More images HERE on FB ]
Dorohedoro - Caiman collectible details:
*Lizard head with exchangeable face parts (total of 2 face parts);
*Gas mask head;
*Store's kitchen knife with sheath x 1;
*M7 bayonet knife with sheath x 2;
*M9 bayonet with sheath x 1;
*Bento box with gyoza inside x 2 (comes with cloth wrapping);
*Comes with following exchangeable hands:
-Open hands x 1 pair;
-Fists x 1 pair;
-Hands for holding knives x 1 pair;
-Right hand holding chopsticks.
[ More images HERE on FB ]
What would be exclusive to the Threezero Store online, is THIS version (seen below), which to me is a no-brainer purchase (heh), and features the following accessories:
*Severed lizard head (top of the skull opens up to reveal brain);
*Formalin jar for storing the severed lizard head;
*Neck joint used to attach the severed lizard head to the body.
[ More images HERE on FB ]


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Miley Cyrus Gets Freaked Out by Fan Rushing on Stage (Video)
Miley Cyrus was performing her song 'The Climb' on Friday when a fan jumped up on stage and rushed up to the singer from behind.
The excited concertgoer put her arm around the startled singer, but was quickly tackled by a security guard who pulled the fan off stage as she held onto Miley. "Oh my God,' the pop star said. "Oh my God."
The security guard then turned to Miley and led her off the stage. The 18-year-old was not injured, but looked shaken by the incident.
Miley is currently in Australia on her Gypsy Heart tour, which runs through July 2. Watch a video of the fan rushing on stage below.


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We have not found dealer information. Please visit Dealers page to find dealer information in your area.
Dealer Service Reviews
No matter what, do not go through the dealership for financingWritten by twinsister on 01/12/12 09:00:18 PM PST Go back to Service reviews
Recommend this dealer? No
I recently bought a Kia Soul from here and the sales person (Sean) was very nice, aggressive and kept doing follow up calls, but the dealership had given me a lower rate than my bank (at that time) when my bank gave me a lower rate, I tried to get out of the financing through the dealership (he hadn't submitted the paperwork) Jeff Scott, the Financial Business Manager did not budge and kept telling me the loan had already been processed. Well, it has been two weeks and I received no paperwork from the bank. He never did follow through with any of his emails. He may come across warm and trustworthy, but I will never recommend this guy to anyone. If you finance with them, I would request someone else who will keep you in the loop on things and will not be pushy and lie to you.


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Professional Services
SecureLink is used by some of the world's largest companies in secure, regulated industries, including healthcare, government, finance, gaming, and higher education.
Since 2003 we have concentrated our approach to accommodate secure environments.
As leaders in this space, we have built substantial knowledge and experience within our team. In addition to our remote support product platform, we offer professional services to optimize your operations.
"In 29 years with the company, I've come to appreciate a partnership like the one we have with SecureLink. We've worked with some companies that have great products, but terrible service. SecureLink has earned our trust with both the quality of the product and passion for customer support that rivals our own."
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Thursday, March 17, 2011
Happy St. Patrick's Day!
6 comments:
- Pamela Holderman said...
Oh those are beautiful. An Irish meal sounds wonderful. Now I just need to get someone to make me one...
- March 17, 2011 at 5:14 PM
- Tracey said...
Happy St Patricks Day...enjoy you meal :)
- March 17, 2011 at 7:15 PM
- AutumnLeaves said...
Gosh Deb...This is such a gorgeous display, a perfect still life setup using my favorite color. I could gaze at this all day. I love your taste in antiques and I could see myself wanting this piece too.
- March 18, 2011 at 2:55 AM
- Brian said...
Very nice! I hope your St. Patrick's Day was green and purrfect!!!
- March 18, 2011 at 7:37 AM
- Candy said...
This is so pretty! The tea cup is so delicate and lovely. I love the biscuit jar, too. Things that are hand painted are treasures.
Thank you for the green tip:)
Have a wonderful weekend!
- March 19, 2011 at 5:50 AM
- Magento Themes said...
wow..fabulous!!! These biscuit jar and tea cup designs,its are really awesome. I love this color and flower design. Its so beautiful and cute.
Thanks for this great post.
- May 3, 2011 at 3:40 AM


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Nokia 603, another Belle phone due for Nokia World?
Nokia seems to be on a spree to release lots of mid-range phones running on the orphaned Symbian OS. After Nokia 500, 600, 700 and 701 we have another phone running on Symbian Belle and is expected to have the title 603.
The specs are similar to the other phones with 1 GHz processor, 5MP Fixed Focus Camera etc.
- 1GHz Processor
- 5MP EDoF Camera
- 360*640 Display
- Symbian Belle
- Nokia Browser 7.4
- Micro SIM
- Bluetooth
- Bluetooth, GPRS, EDGE, WCDMA, HSDPA, WLAN b/g/n
- Inter-changeable back panels


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After the Fukushima meltdown, Japan's nuclear restart is stalled
Link: http://www.washingtonpost.com/blogs/monkey-cage/wp/2014/08/15/after-the-fukushima-meltdown-japans-nuclear-restart-is-stalled
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Trouble with this page? Disability-related accessibility issue? Please contact us at firstname.lastname@example.com so we can help.


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Blue Plate Radio Guestbook
So glad that I found your station!
So glad that I found your station I only have been listening to CD's instead of the radio. Just couldn't find the jazz station that I could pick up. Looking forward to hear what i've been missing. Thanks
Thomas Perez
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Thursday, February 3, 2011
A Benefit to the Cold
13 comments:
- Collette Osuna said...
Love these pics....and the outfit...the scarf is really gorgeous...and I have a feeling Im going to really be relying on a few of my scarves through this remix....:)
Stop by and say Hello♥
Let's Rock the 30x30 Remix..check it out!!♥
- Thursday, February 3, 2011 at 6:54:00 AM PST
- Lisa Fergus said...
Great outfit! LOVE that sweater and the detail on the arms!!
- Thursday, February 3, 2011 at 7:44:00 AM PST
- ~L~ of Avid Accents said...
i love the scarf tied and im also in love with the 70s. It was refreshing to see designers dig into the 70s on the spring 2011 runway.
- Thursday, February 3, 2011 at 8:02:00 AM PST
- jenn~the stylish housewife said...
I LOVE this outfit! The sweater and jeans are really cute. The jeans have the perfect amount of flare =) xo
- Thursday, February 3, 2011 at 8:05:00 AM PST
- The Curvy Girl said...
FABULOUS outfit...you look so comfy casual! I only wish it got cold enough here in FL to rock a look like this. Well done!
- Thursday, February 3, 2011 at 9:26:00 AM PST
- Chelsea Rae said...
You made your scarf? It's so pretty! Jewelry is one of the only things I'm good at making with regards to fashion. It's sort of soothing.
You should inform your hubby that he wouldn't have to complain about packed snow if he shoveled for you first, and while he's outside he could be a dear and be your adoring photographer. ;)
- Thursday, February 3, 2011 at 9:32:00 AM PST
- Josie said...
The sweater is so beautiful!
- Thursday, February 3, 2011 at 9:55:00 AM PST
- Ashley said...
Ooooh I love your jeans! They are so cute on you! I love the seventies era, too!
Stay warm, girl!
- Thursday, February 3, 2011 at 12:48:00 PM PST
- Frances Joy said...
I'm digging your seventies style. It makes me want to find a pair of flare jeans so badly.
- Thursday, February 3, 2011 at 2:02:00 PM PST
- Emma at Daily Clothes Fix said...
Yay for 70s and flares. I love it too and managed to pick up a £1 pair of flares at a charity shop (pre- 30 for 30, obviously). So excited to be wearing them soon.
- Thursday, February 3, 2011 at 4:22:00 PM PST
- Snappy-Q said...
Yeah you rock the 70's style! And I have been meaning to say for a while that I really like your hair colour, it looks great.
- Friday, February 4, 2011 at 8:21:00 AM PST
- kris said...
I love the layering. All your photos are beautiful. I love the simple-chic look on Day 1.
- Saturday, February 5, 2011 at 8:27:00 AM PST
- Daphne said...
Love those jeans. The cardi looks so cozy.
- Sunday, February 6, 2011 at 12:05:00 AM PST


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Welcome lovely one
I'm Caz and in this cozy community I help busy women learn to nurture and nourish themselves using tiny pockets of time and energy that make a real difference to their sense of well-being.
I'm passionate about teaching women who 'don't have enough time' for self-care, to do just that!
Here's what I've noticed
As women, we are totally brilliant at busying ourselves taking care of others' needs, particularly those we love or feel responsible for. It seems so important to do all those things for others, at home, at work, within your community. It is important. You're needed. And you 'should' be able to cope. Shouldn't you??
It's so easy to put our own needs off until later. Tomorrow I'll… Next week… Next month… I'll be ok. I'll get through. I'll survive.
But eventually
You're exhausted, depleted, existing in fight or flight mode all the time. You start to forget who you are. What is important to you. How to laugh, relax, have fun.
You're so tired you slide into just numbing out in front of the TV or social media. You eat for energy (hello sugar and processed carbs!). And then beat yourself up for doing it.
Maybe you're so pressured for time that you can't stop thinking of your to do list, even when you can finally stop for five minutes.
Circumstances are such that you can't leave for a few hours to do a yoga class let alone a weekend with the girls. What you'd give for some 'me' time.
You're so tired that getting up an hour early to meditate or exercise is just not an option.
There are so many demands on your finances that you can't justify dropping $100 on a massage, even if you did have the time or energy.
You want more from life than existing. You do want to take care of yourself. If only someone would take care of you. Ease that ache around your heart.
I hear you, my lovely
I've been there. I have totally been there. I spent years and years pushing through, taking care of my loved ones through a variety of challenging circumstances with my needs never quite making the list.
I knew something had to change when I shouldn't shake off the continual tiredness and stress. Ill health. I was not enjoying life as I had hoped for. I was often wishing the days away.
But then I found a new way
I started by learning not to listen so intently to that inner mean girl and to explore what it was that I really valued, who I really was, who I wanted to be.
I explored self-care in a way that worked for me; food as a healing force; and developed a deep sense of gratitude for who and what I have in my life. I listened closely to my heart to learn what my soul was craving.
Why survive when you can thrive?
Today I feel much more in touch with who I am, including parts of me that I ignored or denied for years. My soul feels more nourished, my creativity is flourishing once again and my home is an imperfect sanctuary where I love to spend time alone, with my family and with treasured friends.
Things I have learnt
To embrace the perfectly imperfect
To treat myself as I would treat a beloved friend
To listen to my heart
To start before I am ready
To trust my intuition
To laugh and be free once again
That food can be powerful medicine as well as bring great joy.
That I am capable of so much more than I thought. That I know much more than I thought.
I've learnt how to take much better care of my needs whilst still keeping all those balls in the air and I'd love to show you that it's possible for you too.
Picture this
Imagine feeling like there was time and space each week day just for you. Snippets of time that made you feel like you again. The old you. Or the new you. You choose.
When life feels like there is nothing for you but work, caring and other responsibilities, there is a way you can take snippets of time and give generously to yourself.
Your heart will thank you for it.
You can give yourself what you need.
You can nurture and nourish yourself and begin to thrive again.
You can learn to be a friend to yourself. A very good friend.
Your cortisol will drop.
Your muscles will relax.
You'll smile more easily.
The burdens you carry will feel lighter.
You will feel loved by yourself again.
You can do this. You are so worth this.
My mission is to share my experiences with you along with the insights and tools I've discovered. I want to help you discover what your heart is whispering so that you can shape the happy, healthy and content life you crave and deserve.
Home Heart Haven is about the little things you can do to make your own life more…you.
It's about learning to nurture and nourish yourself.
It's exploring a happier, healthier way of being.
It's gentle, it's loving, it's incremental change that is achievable and sustainable.
It's a space for sharing stories about going back to basics and discovering what's important in your life.
It's about going deeper and finding greater simplicity.
For simple self-care strategies and tips to create some calm amongst the chaos, I invite you to join the Home Heart Haven community HERE.
As a special thank you gift from me, you'll receive my Bliss Bombs poster featuring inspirational bites of self-care for when you most need it – when you don't have a scrap of time or energy for you.
Self-care is not selfish. It is essential.
You can also connect with me on social media
I look forward to chatting with you soon.
Much love


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Season 52 was full of bright lights
What did YOU see? The Fifty-second Season has ended, but not the memories. As we shift from our performance season to planning for 2018, we'll be updating site information, … [Read More]
People & Partners
Sponsors! Patchwork Shows and Windsock Camp! Season 52 offered multiple opportunities for sponsors and advertisers, plus local opportunities for work and … [Read More]
Special Activities and Events were plentiful this summer: Read about the success of our amazing Challenge opportunity - and our Grand NYC getaway Raffle . . . … [Read More]
Patchwork Players
The PATCHWORK PLAYERS - 2017-style! These talented performers put their own original twist on classic tales and themes designed for the kid in everyone. On the road and … [Read More]
Award-winning, professional theatre in NH's White Mountains since 1966 . . . Our resident acting company performs in alternating repertory all summer long in new productions of Broadway's best, both classic and contemporary. Plus, enjoy family-friendly children's shows, an intensive day camp for youth, and special events.


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Back to Journals » Neuropsychiatric Disease and Treatment » Volume 7 » Issue 1
Long-term safety and tolerability of open-label aripiprazole augmentation of antidepressant therapy in major depressive disorder
Authors Berman R, Thase M, Trivedi M, Hazel, Marler, McQuade, Carson, Baker RA, marcus R
Published 24 May 2011 Volume 2011:7(1) Pages 303—312
DOI https://doi.org/10.2147/NDT.S18333
Review by Single-blind
Peer reviewer comments 4
Robert M Berman1, Michael E Thase2, Madhukar H Trivedi3, James A Hazel4, Sabrina Vogel Marler5, Robert D McQuade6, William Carson7, Ross A Baker8, Ronald N Marcus9
1Neuroscience Global Clinical Research Bristol-Myers Squibb, Wallingford, CT, USA; 2Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; 3Division of Mood Disorders Research Program and Clinic, University of Texas Southwestern Medical School, Dallas, TX, USA; 4Neuroscience Global Clinical Research, Bristol-Myers Squibb, Wallingford, CT, USA; 5Global Biometric Sciences, Bristol-Myers Squibb, Wallingford, CT, USA; 6Global Medical Affairs at Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA; 7Global Clinical Development, Otsuka Pharmaceutical Development and Commercialization Inc, Princeton, NJ, USA; 8Neuroscience Medical Strategy, Bristol-Myers Squibb Company, Plainsboro, NJ, USA; 9Neuroscience Global Clinical Research, Bristol-Myers Squibb, Wallingford, CT, USA
Background: Effective management of major depressive disorder often includes the long-term use of multiple medications, and the longer-term utility and safety of adjunctive aripiprazole has not been evaluated in a controlled setting.
Patients and methods: Patients (n = 706) completing one of two 14-week double-blind studies of aripiprazole augmentation, as well as de novo patients (n = 296) nonresponsive to current antidepressant therapy, were enrolled in this open-label study. Patients received open-label aripiprazole for up to 52 weeks.
Results: Open-label treatment was completed by 323 patients (32.2%). At endpoint (n = 987), the mean dose of aripiprazole was 10.1 mg/day. Common (>15% of patients) spontaneously reported adverse events were akathisia (26.2%), fatigue (18.0%), and weight gain (17.1%). The incidence of serious adverse events was 4.0%. Four spontaneous reports of possible tardive dyskinesia were submitted (0.4%); all resolved within 45 days of drug discontinuation. Mean weight change was 4.4 kg; 36.6% experienced ≥7% increase in weight from baseline (observed case analysis, n = 303). No clinically relevant changes in other metabolic parameters were seen. At the end of open-label treatment, 221 patients (69.7%) had a Clinical Global Impression-Severity of Illness score of 1 (not at all ill) or 2 (borderline ill).
Conclusion: Long-term adjunctive aripiprazole therapy was well tolerated with an acceptable long-term safety and tolerability profile in patients with major depressive disorder who had not responded to treatment with one or more antidepressant therapies. Clinically significant weight gain was observed in about one-third of patients. Overall, the adverse event profile was consistent with that reported in the short-term trials and readily managed clinically.
Keywords: adjunctive aripiprazole, antidepressant therapy, major depressive disorder, long-term safety and tolerability
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Other article by this author:
Augmentation treatment in major depressive disorder: focus on aripiprazole
J Craig Nelson, Andrei Pikalov, Robert M Berman
Neuropsychiatric Disease and Treatment 2008, 4:937-948
Published Date: 10 October 2008
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Saratoga library room gets update
The children's room at Saratoga Springs Public Library is getting a $425,000 renovation and refurnishing starting Wednesday.
"It will be a top-to-bottom transformation of the room," said library director Ike Pulver.
While the transformation is taking place and contractors are busy in the library's basement — where the children's room is located — children's library activities and materials will be located in the Harry Dutcher Community Room on the library's first floor.
Jennifer Ogrodowski, head of the library's youth services, said the work in the children's room is expected to take approximately six weeks.
During that time children's library materials, a selection of toys from the library's Rainbow Room, and special programs for children and families will be held in the Dutcher Community Room.
The library is located at 49 Henry St. in downtown Saratoga Springs.
The ongoing children's programs will include Family Story Time, Library Babies, and a smaller version of the library's Parent Child Workshop.
The children's room renovation will include painting, new wallpaper, new carpeting, and new seating for adults and children.
The popular Rainbow Room will be expanded to double its current size. Wall-mounted, manipulative, hands-on learning stations for toddlers and younger children will be installed on the walls of the Rainbow Room, Ogrodowski said.
"Shelving will be reoriented so the room has a more open feel to it," Ogrodowski said. A second self-checkout station will be added.
Pulver said the reference desk in the children's room will be changed so that library staff members are out "front and center" rather than behind a large post.
Gina Michelin, the library's new community relations coordinator, said most of the children's room materials had been moved up to the Dutcher Community Room by late Friday afternoon.
"It's going to be spectacular," Michelin said about the children's room renovation.
The children's room has always been a popular place for the community. Michelin said she remembers bringing her daughter to the Rainbow Room when she was a baby.
The project has received donations of $20,000 from the Saratoga Springs Rotary Club and $20,000 from the Friends of Saratoga Springs Public Library.
Pulver said the project also received a $52,167 grant from the state's Public Library Development Fund as well as a total of $9,000 in funding from state senators Roy McDonald and Hugh Farley.
The general contractor for the project is Giangrande Building Services with headquarters in Castleton. The electrical work, including all new lighting, will be done by LaCorte Companies of Troy.
"It is our hope that the new Children's Room will become a destination for children and families to visit over and over again," Ogrodowski said.
She said parents and caregivers will find more comfortable furniture as well as new displays and more space to easily browse materials when the renovated children's room opens in mid-February.


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SPRINGFIELD, Ohio (WDTN) – A Springfield teen accused of murdering his 14-year-old brother will be tried in a Clark County adult court.
Nicholas Starling, 16, is accused of beating and stabbing his 14-year-old brother Harley to death in October. Nicholas Starling was the only suspect in the case.
READ MORE: Police: 16-year-old is sole suspect in 14-year-old brother's death
Harley Starling was found dead inside a bedroom of his grandmother's house in the 2200 block of Superior Avenue in Springfield.
The grandmother told police she went downstairs around 5:30AM Monday to get Harley ready for school when she found him dead.
Police records revealed the Springfield High School freshman was "cold to the touch" and "was clearly dead and had been for several hours" prior to their arrival.
It is the policy of WDTN and WDTN.com to not name juvenile suspects. Now that Starling's case has been moved to adult court we are using his name.