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The holiday season along with its lights and celebrations, often brings some unwelcome guests, stress, fatigue and depression. It is of no surprise that the holidays present an accumulated amount of demands such as shopping, cooking, cleaning and entertaining among many others.
"Enjoy the Holidays: Turn Holiday Stress Into Holiday Cheer" was written by Rebecca Cofiño to help readers recapture the magic of the holiday season. Unfortunately, recent years have seen the holidays turn into a season of stress that robs people's credit cards, time, consumes patience and drains energy. Every year individuals strive to relive the experience of joy felt as children. Yet, somehow the holidays end up spinning things out of control.
Referring to the holidays as a single entity, the author presents an interesting calculation. Almost 17 percent of an average individual's life is spent celebrating the holidays. This generally accounts time spent from mid-November till halfway through January. However, if the celebrations start earlier or include an extravagant Halloween, the percentage of time spent on holidays shoots up to 25 to 30 percent. The author terms this as "jumping on the Holiday Express" that takes one nowhere except in loops.
Cofiño discusses building a holiday experience full of meaning rather than one just based on perfectionism and consumerism. After all, 17 percent of a year is a significantly long period of time to spend feeling stressed out, pressured, overwhelmed and exhausted. The food and the lights take people away from real goals that form the very essence of their well-being. It puts unnecessary pressure on time, finances, energy and other resources that would have been directed toward life goals.
The trick to remain grounded amid such chaos is simple: stay in the present. It is important to realize that holidays have strong underlying elements that they are essentially based upon. These are gratitude, salvation, a celebration of blessings, cultural heritage and family.
The book further continues to explore in detail the various ways that can allow an individual to enjoy the holidays rather than be overwhelmed by them. Budgeting is an important component to make this work. The author claims that even though it's not enjoyable, budgeting is "an incredible part of empowerment." This budget is not just limited to money, but extends toward time and energy as well. All three of these elements are valuable and can easily be overspent on things that do not really matter.
This book explains in detail the ways to incorporate mindfulness into holiday celebrations, alongside offering an array of practical tips to make the holidays go smoothly. Furthermore, the book addresses budgets, mental and physical health, perfectionism, family life, stress, organization and making the holidays meaningful; it offers a simple, yet important promise of bringing back the joy into the holidays.
"An enjoyable book with terrific tips for taking care of yourself during the hectic season. Reminds me of what the season is meant to be!" said a satisfied reader's review.
About the author
Rebecca Cofiño is a mindfulness expert who specializes in everyday spirituality and family life. She is the founder of the website mamaguru.com, devoted to helping people discover a meaningful happiness.
She is both an author and public speaker. "Enjoy the Holidays: Turn Holiday Stress Into Holiday Cheer" is her first book.
Cofiño grew up in the Pacific Northwest, but spent her twenties traveling the world, visiting four continents and living in three different countries. She has studied yoga in India and has been a certified yoga instructor and meditation teacher for over fifteen years.
She currently lives in Miami with her husband and two sons.
Written by Sana Ahmed, Sovereign Health Group writer


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Download Adecco Jobs in Czech Republic apk 2.0.3 free for Android smartphone
Posted by Adecco Czech Republic in Business | June 4, 2015 | 0 Comments
Apk file size: 8.9 MB
The ideal application for those seeking employment in Czech Republic. The easiest and fastest way to find job offers.
Adecco Jobs is the official Google Play job application for the Czech Republic market.
Adecco is the leading recruitment and staffing company in Czech Republic, with many vacancies for you to search among. Adecco application also includes a job search guide with tips on how to create a great CV, write a stand-out job application and how to perform your absolute best at a job interview.
The Adecco Jobs in Czech Republic for Android is a premier tool to search for jobs in Czech Republic, locate branches and get the best career news content on the web!
Whats new
Version 2.0.0:
● All the features you love with a fresh new look and feel.
● New features, login with Twitter, upload your CV.
● Refresh your job list
● Improvements.
Adecco Czech Republic part of our Business and have average installs from 1000 to 5000. Last Update June 4, 2015. Google play rating is 63.3333. Current verison is 2.0.3. Actual size 8.9 MB.
Similar applications
Adecco Switzerland Jobs&Career13 Comments

subset: commoncrawl


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Monday, October 17, 2016
Thomas Woods: Why the 14th Amendment to the Constitution was never really legally ratified
Posted by Steve Bartin at 9:50 PM
The total link site for the news and information junkie: Libertarianism. Property Rights. Government Corruption. Chicago Mob. Struggle Against Socialism. Union Corruption. Pension Meltdown. Blacked Out History. New York Mob. Higher Education rip-offs. Housing Bubbles. Rent-seeking. Chicago Democratic Machine. Gun Control Monopolists.Deep State. Organized Crime...Other Politically Incorrect matters of interest.


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Available Dates
WINTER 2018 CLASS February 24–25, 2018 (Saturday and Sunday) 10am–6pm
FALL 2018 CLASS September 29–30, 2018 (Saturday and Sunday) 10am–6pm
Don't forget to read our class policies before you register.
Class sold out? Special request? We want to help! Email us at hello @ workroomsocial.com.
LocationWorkroom Social
96 Madison Street
Bed-Stuy, Brooklyn
Hours in Class16 hours over 2 days
(50% deposit required to enroll. Remaining balance due one week before your class date.)
Class Description
Check out the button-ups that sewists just like you are making!
Anyone can sew their own clothes! It just takes a little imagination, some instruction, and practice.
In our Button-up Shirtmaking Weekend Sewing Intensive, learn how to sew a button-up shirt. Button-ups may seem intimidating, but anyone can make a collared shirt that looks store-bought! In this weekend sewing class, you will gain confidence and experience in sewing collared shirts with our effective and encouraging instructors.
As part of our Learn to Sew classes, sewing instruction is taught with an emphasis on key industry skills and techniques to create professional-looking garments at home. All of our sewing classes are both fun and productive, instead of just one or the other. We encourage anyone who is interested in sewing clothes to join us for this weekend intensive, whether you are strictly a hobbyist or interested in learning construction skills to bring your original fashion designs to life.
Our Button-up Shirtmaking Weekend Sewing Intensive is like taking a 2-day sewing vacation, and we've taught wonderful students from all over the world. We invite you to spend a weekend working with us in our inspiring and friendly studio. After this class you'll start your week with a brand new, handmade garment to wear and lots of excitement to continue your sewing adventures!*
Read more about what to expect from your class at Workroom Social.
Classwork includes…
- How to properly fuse fabric for fashion sewing.
- A quick and dirty method for plaid matching.
- How to install sleeves.
- How to make continuous plackets.
- How to install a shirt collar and collar stand.
- How to make a front button placket (button band) with buttonholes.
- How to install shirt cuffs.
- How to make and install professional looking patch pockets.
- How to sew a shirt yoke.
- Tips and tricks to improve your overall sewing skill set.
Tuition includes…
- Lunch and treats both days.
- Grainline Studio's Archer button-up shirt sewing pattern (men's sewing pattern available upon request).
- Handouts and other supporting materials.
- Use of studio equipment and tools. If you prefer to work on your own sewing machine, you are welcome to bring it. Students are responsible for purchasing their own supplies. Supply lists are emailed to enrolled students about two weeks before each class date.
Skills needed to take this class include…
- Experience setting up, operating, and troubleshooting sewing machines.
- Experience sewing straight and curved seams.
- A general understanding of sewing patterns.
- This class is designed for an advanced-beginner to intermediate level sewer.
Are you an absolute beginner who is interested in taking this class? We'd love to have you! Please email us at hello @ workroomsocial.com for more information on how you can take this class.
Don't let a company control what you wear. Own your style and your clothes by making them yourself.
At Workroom Social, we specialize in teaching adults how to sew clothes that fit both their individual styles, and also their unique body shapes and sizes.
Our sewing classes are designed for adults to learn in a warm and non-competitive environment. Perfection is never our goal; rather, students should expect that over time their skills will improve practice. Our team of professional designers and sewists make garment sewing approachable, and it's our goal to provide students with the confidence and the knowledge you need to continue practicing sewing at home.
Through sewing we build communities, stimulate creativity, and help improve women's self-esteem and confidence by empowering them to sew the clothes they want to wear.
*While we cannot guarantee that each student will complete her garment, the majority of students do.
**Please be sure to read our class policies. If you have any questions about classes and learning at Workroom Social, please email hello @ workroomsocial.com.


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Earlier this year, I entered a cook off challenge with D'Italiano. The requirement was that we submit an original recipe using any of the D'Italiano bread products. I wanted to submit something that was remarkably different from a sandwich, and from my indulgence of watching the Food Network channel, I was motivated to make something deconstructed.
I first had the idea of making a soufflé using D'Italiano bread, and then my idea just expanded to incorporating the elements of a cheeseburger. I was nervous as I watched my soufflé rise in the oven, and I felt I had to hurriedly snap photos of it as soon as I removed it from the oven. This was a completely experimental recipe for me!
Since I decided to share my recipe with you on my blog, you can guess that it turned out well. I have to admit, I was pleased with my deconstructed bacon cheeseburger soufflé. I have to warn you, it was a heavy meal, but it was a welcoming experience to taste a cheeseburger this way. It was definitely a welcoming change in texture, and I encourage you to try it at least once! Of course, you don't have to use D'Italiano bread, as any bread slices will do. I'm happy to hear your comments and stories!
Grocery list
2 tablespoons butter, for the ramekins
150 g bacon
2 cups milk
1 tbsp cornstarch
1 tsp salt
1/4 tsp black pepper
1/4 tsp cayenne pepper
1/8 tsp mustard powder
1 tbsp granulated sugar
1 tbsp butter
270 g lean ground beef
8 slices D'Italiano white bread, crusts removed cut into 1/2-inch cubes
3 egg yolks
5 egg whites
170 g Swiss cheese, grated
Chipotle ketchup
1/4 cup ketchup
1/2 tsp chipotle pepper flakes
1/4 tsp ground cumin
1 tbsp lime juice
Butter ramekins and coat with granulated sugar, shaking out excess sugar, then space apart on a rimmed baking sheet lined with aluminum foil.
Heat a non-stick skillet on medium heat for 1 minute. Add the bacon and cook for 3 minutes on each side until crispy. Drain the excess oil as much as possible and place the bacon strips on paper towels to absorb the oil. When the bacon is cool enough to touch, crumble it into small pieces.
Whisk together the milk, cornstarch, salt, black pepper, cayenne pepper, mustard powder, and sugar in a small saucepan.
Bring to a boil over medium heat, whisking constantly.
Reduce to the heat to a low simmer and whisk for 2 more minutes.
Preheat oven to 400° F with an oven rack in the lower third of the oven.
Place the bread in one layer in a baking dish and pour the hot milk mixture over it.
Turn the bread cubes until evenly coated and set aside until the liquid is absorbed.
Meanwhile, melt the butter in a medium skillet over medium-high heat. Add the ground beef and cook until the meat is no longer red, about 15-20 minutes. Season with salt and pepper and set aside.
Using a wooden spoon, mash the bread gently and stir in the ground beef mixture and the bacon. Transfer to a large bowl and cool to room temperature.
In a medium bowl, whisk together the egg yolks and cheese, and then pour over the bread, stirring until well combined.
In the bowl of an electric mixer, beat the egg whites on high speed with 1/4 tsp salt until stiff, glossy peaks form, about 5 minutes.
Fold 1/3 of the whites into the cooled bread mixture to lighten it, then fold in the remaining egg whites gently but thoroughly.
Divide mixture among ramekins, mounding it. Run your thumb along the inside rim of each ramekin to prevent the soufflé from sticking when it rises in the oven.
Bake soufflés until puffed and golden, 25 minutes.
Meanwhile, combine all the ingredients for the chipotle ketchup in a small saucepan and bring to a simmer over medium heat. Cook, stirring frequently for 1 minute. Remove from the heat and let cool to room temperature.
Remove the soufflé from the oven and serve immediately with the chipotle ketchup on the side.
Related posts:


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If you are an eagle-eyed viewer of this ol' blog, you may have noticed that this before used to be an after! It's ok if you didn't notice. I have over 1,200 posts. You'd kind of have to be a stalker to notice that. And it's fine if you DID notice. I don't mind stalkers. Just don't come to my house and watch me sleep or anything, ok?
So LeAnn had this built-in bookshelf that she didn't love. She made it work for a while with some turquoise paint and new knobs, but it was kind of a thorn in her side. So she did something completely irrational, ripped it out and replaced it with turquoise zebra print wallpaper. Hey, nobody ever said rational equaled fun. I love the whole new look in the entire room. Check it out on her blog For the Love of Cottage.


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This is a nice place for lunch/dinner with family. It has an arcade for kids and the food is great. They also have great service.
1 - 10 of 43 reviews
This is a nice place for lunch/dinner with family. It has an arcade for kids and the food is great. They also have great service.
Nice tasting pizza. I was there between lunch and dinner so not very busy. Service was good. Use a coupon and get a deal.
I think this is the perfect place to take the whole baseball team after a game: loud, fun and with pizza. The pizza is really average, but good to feed large groups of hungry teenagers.
We visit when in town on business and this is an affordable choice with great food, attentive staff and a nice selection of beverage options! A solid choice that you wont regret
Walked into the place and it smelled like bleach and dirty bathrooms. A large pizza was$35 and tasted like a frozen pizza. Th bathrooms smell like vomit and the doors slam making the noises not worth it. High priced and crampy food and smells like...More
This place is great,very sociable staff and a great pint of beer and Great food.Ask for a Club Chicken Flatbread with avocado,mmmmmm,,,, It's such a great atmosphere in here.We loved it.
Party of two, came in around 3pm on a Tuesday. We sat at the bar with Delilah. Quick to greet us but then was no where to be seen the rest of our visit. Our appetizer order of wings (4 out of 5 stars on...More
Ours was an on-line take out order. It was ready 10 minutes later than we were advised. The pizza was tasty and well prepared. The chicken wings were a hit with our group. While waiting for my order I looked around. It isn't the most...More
We came here at 2 pm hoping for a quick late lunch; my husband was especially excited because of the beer selection. But when we walked in, nobody greeted us. We wandered through the restaurant to the seating area by the bar, where there were...More
Been there several times with my friend Doug for Monday night football. We sit out on the patio, drink beer and eat pizza. I really like it.


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There are many "myths" involved with Medi-Cal planning, but few people (even fewer attorneys) really know what their rights are with regards to protecting their home and assets, should they have to be admitted into a long-term care facility in the future. So how much do you know about Medi-Cal planning? To find out, just take the Medi-Cal test for the calendar year 2017 below: Do I have to give away everything I own to get Medi-Cal? No, if you are a couple, the at-home spouse can ha...More
If you are a veteran (or their spouse) you may be eligible to receive a monthly "tax free" benefit to help pay for your current or future in-home care, assisted living care and/or board and care needs. This monthly benefit will give the couple or the single person about $1,100 - $2,000 (approximately) each month for your care and support needs as the situation applies. To be entitled to this benefit you must meet the following criteria: Be a veteran of a "wartime period" or their spouse ...More
Serving Sacramento, Placer, El Dorado and Yolo Counties
Estate & Med-Cal Planning, Elder Law for Seniors
VA Program Application Assistance for Veterans
It's Never Too Early to Start Planning for Tomorrow
Protect Your Assets For Your Family
Estate Planning for Wills and Trusts
It's Your Life…Plan For It!
Hello world!
Welcome to WordPress. This is your first post. Edit or delete it, then start blogging!More


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Modern Russia Composers
first edition
1927 · New York
by SABANEYEFF, Leonid
New York: International, 1927. Very Good. First edition. Very good Light browning to pages, name on end paper. Cover rubbed with some light wear along edges, corners. Paisley print on boards. Please Note: This book has been transferred to Between the Covers from another database and might not be described to our usual standards. Please inquire for more detailed condition information. (Inventory #: 119806)


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Posts in the Crime and Legal category:
Street Robber Tries To Steal Cell Phone From MMA Fighter; Begs For Life
This guy made a mistake when he tried to steal a phone from MMA fighter Monique Bastos on the streets of Brazil. After she put him in "the triangle" hold, he began to call for his mom, dad and probably any other relatives he has.
What can we learn from all this?
1. Ask the people you rob if they are MMA fighters.
2. If they say yes, believe them and go get a job.
3. If you don't believe them, prepare a list of all your relatives you will cry out for when they put you in "the triangle."
Listen, You Can't Come In Here Without A Warrant
Gilly the Camel: "Listen, you can't come in here without a warrant."
Middletown Ohio Initiates Laser Program To Stop Traffic Light Scofflaws
Podcast: Play in new window | Download
Middletown, Ohio recently deactivated their red light traffic cameras at intersections around the city in order to bring the town a new system.
"There's been some confusion," said the mayor of the town. "Some people thought our automated red light cameras were illegal. That's not it at all. The red light cameras are legal, they're just not very efficient. We had the same motorists breaking the same laws over and over."
Rather than issue citations to repeat offenders, the new procedure is that the license plates of repeat offenders will be kept in a image database at the State. When the computer determines that an offender has once again made the same traffic violation, high-powered lasers will fire from the top of the traffic lights, sending a high-powered beam at the automobile.
Once the beam reaches its highest intensity, the car will be rendered useless. At the same time, the intense focus of the laser will make the driver drowsy. With the car rendered inoperable, and the driver as well, the laser will then send a message to the nearest police officer to arrest the driver and tow their car to the nearest impound lot.
"This is the safest method we came up with to deal with repeat offenders," explained the mayor. "The laser renders both the automobile and the driver completely inoperable. We will tow the car to the nearest impound lot, and make the arrangements to sell it. The driver will be taken to the local police station, booked and given time to sleep off the effects of the laser. Once they are back to normal, we will issue them a bicycle instead of a car because clearly they cannot use an automobile like a responsible adult. For winter, the bicycles will be issued special snow tires so that people don't have to miss work, church or family obligations due to inclement weather."
The lasers are currently being tested throughout the Middletown, Ohio area. They will be in full operation beginning in May. There will be no opportunity for residents to voice concerns about the system at the local city Council meetings.
"We find that the people raising the biggest questions and concerns about the laser program are also the biggest suspects in terms of traffic violations," said the mayor. "We have decided not to allow anyone to give us feedback on the system. Rather, we look forward to having the opportunity to remove these complainers and anarchists from behind the wheel, and put them on the seat of a bike where the exercise will hopefully remove some of the desire to break the law and constantly complain."
Lady steals TV underneath dress
Check out this lady stealing a TV set in Costa Rica. Somehow she is able to walk fairly well with it balancing between her legs.


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AMSTERDAM, Netherlands, Aug. 2 (UPI) — Britain's Rolling Stones raked in $152.5 million last year, but thanks to offshore investing, paid only 1.6 percent in taxes, it was reported Wednesday.
The legendary rock group practices in Canada and has had all of its finances handled in the Netherlands since 1972 to avoid paying high British taxes, the Independent reported.
The tax rate is so much lower in the Netherlands because it does not place a direct tax on royalties, the newspaper said.
The musicians have always kept their financial information close to the vest, but the aging rockers have been working on their wills and Dutch law requires certain information be made public as part of the process.


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Product or Service
swimming pool and accessories supply
Profile:Manufacturer - Producer|Ref:PSL3733YH | Country: China | Export: No
Through year's development, our company has established 3 huge-scale production lines: quick up pool, metal frame pool and pool/Spa cleaning accessories. Should you be interested in our products, or you prefer your own design, please don't hesitate to contact us. We can service you well as all your requirements.
Contact the company


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Moving Foward!Posted on Feb 22, 2012
Wow, what a whirlwind of a last week! Over the last couple of months we have been working with multiple agencies and bureaucracies that all have to come together for us to move forward so we can get closer to brewing beer. We have now worked through a site plan review with the city for our location and we have been given the go ahead by The Port of Hood River and The City of Hood River for the building of our brewery and tasting room! We have also been notified by the State Government (OLCC) and the Federal Government (TTB) that we are approved to produce and sell beer!
Once we received all this amazing news, Ken and I spent all last week and weekend hanging our Glycol lines! Just in time, as we needed to finish this project before our contractor started cutting the concrete on Monday! As we were wrapping up the lines, the concrete was being cut, I felt like a giddy little boy with all the excitement!
We are over most the major hurdles that could keep Pfriem Brewing from moving forward!


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Day Five ~ Arches
Moab Travel Blog› entry 8 of 20 › view all entries
After our late evening ride through Arches the day before, we knew a little about the Park and what we wanted to see. We decided to try and get a rather early start, so we ate a light breakfast and checked out of our motel. There was much to experience before we left Moab, and we were anxious to get started.
Arches occupies only a tiny corner, 119 square miles, of the vast Colorado Plateau. But within this relatively small National Park there are over 2,000 natural sandstone arches, some of the most beautiful nature wonders in the entire world. Unfortunately, we were limited to viewing only the formations that were closest to the road.
The road inside the Park has a nice and easy grade, it is well maintained and offers plenty of pull-outs. At every stop we noticed signs beside the trails that warned hikers to Stay on Marked Trails Only. We learned that the barren landscape was actually very much alive. The soil crust consists of lichens, algae, mosses, and microfungi and it is of great ecological importance. In this harsh desert environment, the sparse vegetation needs all the help it can get. If hikers carelessly break a well developed patch of soil crust, it can take up to 250 years for the disturbed area to again become fully functional.
We stopped and pondered over Balanced Rock and wondered just how much longer it would be able to maintain this position. Each and every rock formation within the Park boundaries are in danger of collapsing or breaking at any given minute. Of course, the entire thing wouldn't just fall over, but small pieces can break loose and tumble, surprising or even killing anyone in it's path. The warning signs serve to remind all visitors to exercise caution when climbing, sitting or walking around any of the arches, walls, hoodoos, or towers.,
The road inside the Park isn't a loop road, so after we reached "the end" we turned around and made the ride back to the exit/entrance.
Exploring the town of Moab was next on our agenda. Of course, Jan and I needed to do our shopping. All you ladies out there can appreciate what I am saying. I was looking for an art gallery and spotted a sign, Tom Till Gallery, that caught my eye. Inside the little shop were wall-to-wall hangings of every scenic spot in the entire state of Utah. These weren't just photographs; every image had fully captured the beauty of the place. This was fine art at it's best. I finally made my choices, gathered up my treasure, and joined everyone else outside. It was time to hit the road again. We needed to make Bryce Canyon before dark and time was a-wastin'.


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Love and Compassion
"Love and compassion are necessities, not luxuries. Without them, humanity cannot survive."
Know the Rules Well
"Know the rules well, so you can break them effectively."
Today I am Fortunate to be Alive
"Every day, think as you wake up, today I am fortunate to be alive, I have a precious human life, I am not going...
The Best Answer
"Silence is sometimes the best answer."
The Best Relationship
"Remember that the best relationship is one in which your love for each other exceeds your need for each other."
"There is a saying in Tibetan, 'Tragedy should be utilized as a source of strength.' No matter what sort of difficulties, how painful experience is,...
My religion is Kindness
"My religion is very simple. My religion is kindness."
Absence of Judgment
"Love is the absence of judgment."
Too Small to make a Difference?
"If you think you are too small to make a difference, try sleeping with a mosquito."
Happiness is not something Ready Made
"Happiness is not something ready made. It comes from your own actions."


text: After defeating Asura and having Iria join me in using the manifest, they all decided to go back to Regnum (sp?). However, just as two random NPC's were talking, the game froze (only time my flashcard has froze under no insitgation). Instead of re-defeating Asura (which isn't easy if you're at level 50), can someone fill me in on what I missed? Is it worth another go? Is there any cool endgame abilities that are unlocked? *edit: After a second time, it froze in the same spot. anyone else have this problem?


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Marriott's Ritz-Carlton Pays $2M To End OT Class Action
Ritz-Carlton will pay out to roughly 1,500 current and former employees at three luxury hotels in San Francisco, Half Moon Bay and Lake Tahoe, putting to rest allegations that the chain violated California state wage and hour laws by skimping on overtime.
Both sides said they had faith in their arguments, but that the...
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- Latest
- Popular
- Blogs
- Authors
- Topics
- Our Blog
Our physical and emotional state of mind directly depends on words. While positive words can block out anxiety and fears, negative words, on the other hand, exert the opposite effect. What does it mean? It means: A single word matters! The words you use in the title of your post and in the body of the article will determine the reaction of your readers.
When I first started blogging, I had very naive ideas. I thought that as long as you wrote a great and interesting post, people would just show up and read it. SEO? Never heard it. Title tag? Well, of course, I try to give it a good title. Then I wondered why no one ever read my blog. It turns out that there is a definite strategy to creating a blog post or webpage that p ...


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Welcome to Hugh Fan, your newest source for all things Hugh Jackman. (Many, many thanks to Celyn for the beautiful layout.) I wanted to start this fan site not just because I enjoy Hugh as an actor, but because he genuinely seems to be one of the nicest guys in showbiz at the moment. It's always good to honor someone who deserves it in every realm. So, here is what came of it! Take a look around; there is some content up, although the gallery is not yet opened. I hope you enjoy your stay. Come again soon!
PLEASE NOTE: Updates are to be sparse until 5 January 2011, as I will be visiting London and won't have unlimited internet access. When I'm back, the site will be updated with pictures and steady news on Hugh.


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Join Now!Log in
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Sat 12/31/16: Looking for a way to get on the floor
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Wells Fargo Safe From RICO Suit Over $68M Ponzi Scheme
U.S. District Judge Daniel T.K. Hurley dismissed an amended complaint that accused Wachovia Bank — now part of Wells Fargo — of violating the Florida Racketeer Influenced and Corrupt Organizations Act by its failure to file suspicious activity and currency transaction reports on deposits made as part of an alleged Ponzi scheme.
Judge Hurley...
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10. Because Shake Shack is now in Harvard Square. Enjoy a Crimson Red Velvet frozen custard while reminiscing about buying textbooks and records at the Coop—yes, there once were rows and rows of vinyl there!
9. Because the gooey, sweet Flour sticky bun might be one of the best connections you'll ever make at a conference. (Yes, food again. We're Asian, right?)
8. Because you might meet the next person who will get to name a Harvard school.
7. Because the edge-of-your-seat ELEVATE Pitch Competition is like if competitive sports married Silicon Valley, minus the overpriced hot dogs.
6. Because you're curious if Tiger Mom has claws. Come and find out!
5. Because of all the instruments we've practiced, the loudest should be our voices.
Hear powerful stories, or tell your own at our first-ever VOICES Storytelling Slam.
4. Because you'll learn about and hear from the many great Asian-American athletes that come from Harvard. Yep, you read that right.
3. Because President Faust's Ice Bucket Challenge reminded you of icy Cambridge winters and now you want to visit—minus the whole icy winter part.
2. Because the Kong still serves scorpion bowls.
1. Because hundreds of amazing people will be there. It took four years to pull together this second Summit, and you can't wait that long for the next one!
*With a nod to Harvard Black Alumni Weekend's Top 10 List…and David Letterman


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Former NBA player James White, who played the last two years in Italy, has agreed to a one-year contract with the New York Knicks.
Daniel Curtin, who works at the Three Eye Sports agency that represents White, said the deal amount is for slightly less than the veteran's minimum of $1.4 million.
"He's excited about it," Curtin said. "He's going to have a chance to play. He's come a long way since his earlier NBA stint. I think it's a great opportunity for him, especially with the personnel he'll be playing with. He has some elite intangibles."
The 6-7, 200-pound White was a member of the San Antonio Spurs and Houston Rockets during the 2006-07 and 2008-09 seasons, respectively, but he only played in a total of 10 games.
For the past two years, he has competed in Lega Basket Serie A, the highest level of club competition in Italian professional basketball, and he became one of the top scorers. He led the league in 2010-11 with Dinamo Sassari, averaging 21.0 points per game (in a mostly transition offense), and was top three in 2011-12 with Pesaro, averaging 17.1 points per game (in more of a halfcourt offense).
Not only did White prove he could adjust to two different offensive styles in Italy, but he became more of a complete player, averaging about five rebounds, three assists and two steals per game.
"He's really grown," Curtin said. "This past year, he led the league in free throws made, and his efficiency and basketball IQ were phenomenal. He was also first in the league in assists for any non-point guard. He's made strides in the shooting department, but he's not going to turn into Steve Novak. But his overall polish has increased quite a bit."
While White had feelers and workouts with several NBA teams since playing with the Rockets, the likelihood of another pro contract in the states emerged this year.
"This is the closest that he had been," Curtin said.
The Knicks took notice, likely led by widely-respected international scout, Kevin Wilson, and they flew White in for a workout about 10 days ago at the team's training facility in Greenburgh, N.Y. Curtin said it "went great."
White will be with the Knicks next week in Las Vegas, where they're participating in the NBA summer league. White won't be suiting up, however, but he'll be meeting with his new teammates and coaches, learning the system and training in the area.
In 2001, White was one of the best high school players in the country who earned the nickname "Flight 75" for his leaping ability. He was named to the McDonald's All-American team along with Tyson Chandler, who was drafted second overall by the Bulls that year. While Chandler became a starter in his rookie year, White had to first pay his dues in college, playing at Florida and Cincinnati.
Now, Curtin believes White is ready to play a key role off the bench for the Knicks, like Gerald Green initially did for the New Jersey (now Brooklyn) Nets last season.
"It's been a long time coming," Curtin said. "I think kind of the analogy is the Gerald Green situation. Gerald's a little bit younger and came out of high school, but the same idea. James is a super, super talent and it took him a couple of years to polish his game and develop. He's come a long way."


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With the Pacific National Exhibition just around the corner, Pokémon Go players can not only get free admission at the gates, but there will also be an abundance of perks once inside.
RELATED: Most Popular Spots To Play Pokemon Go in Metro Vancouver
Our friends at the PNE have confirmed that 25 Poké Stops, 3 Poké Gyms and tons of Pokémon will be available to fairgoers.
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The Fair at the PNE kicks off at 11:00am on Saturday, August 20.
Receive free admission during 1 (or all) of these 3 days.


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A missing Hull woman was found safe Wednesday morning after a passing trucker spotted her car in the woods near Olympic Drive.
Friends of Elizabeth Colson, 82, called the Madison County Sheriff's Office about 8:30 p.m. Tuesday to report she was missing after she failed to show up for a 5:30 p.m. meeting at an AMVETS post on Winterville Road in Athens, said Capt. Mike Benner of the Madison County Sheriff's Office.
Deputies searched along her route, but couldn't find her.
A Federal Express driver spotted the woman's Buick Park Avenue about 7:45 a.m. Wednesday and alerted Athens-Clarke firefighters at their nearby station at the intersection of Athena Drive and Olympic Drive.
The woman told firefighters she lost control of her car and slid off the road. She couldn't get out of the car when it came to rest in the woods nearby, she told firefighters.
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|trenches complete
|by laurian | Posted Feb 24, 2010
|trenches made from papiermache
|Tyranid spore forest expanding
|by terrainaholic | Posted Feb 23, 2010
|This is an evolutionary look at my tyranid spore forest from just breaking the ground to an extensive root and spore producing tyranid plant. Let me know what you guys think!!!!!!
|[WIP] Terrain - Bunker
|by THECAKEISALIE93 | Posted Feb 22, 2010
|Well, I decided to try and make a bunker for some terrain because I got tired of using sandbags and stuff from army men sets I picked up at the dollar store.
|WIP city of death
|by shinto-kamikaze | Posted Feb 20, 2010
|inperial tanks of the 1st Grey wolves regement patrol the shattered streets of Repograde capitol city of the planet Volga,ONE MONTH AGO POPULATION 16.2 MILLION,NOW POOULATION 2.1 MILLION
|bank of ireland finished
|by shinto-kamikaze | Posted Feb 19, 2010
|at last
|mortar pit
|by shinto-kamikaze | Posted Feb 19, 2010
|bank defence
|cheap fuel dump
|by shinto-kamikaze | Posted Feb 17, 2010
|2 hour objective
|bank of ireland,part 6
|by shinto-kamikaze | Posted Feb 16, 2010
|warhammer 40k WIPs
|by rockon543 | Posted Feb 16, 2010
|my warboss and first terrain
|First Terrain pieces
|by noobface | Posted Feb 10, 2010
|a few pieces i made from 2" foam for my arid desert board. im making alternate terrain sets with the floating greenery being one set. im loving making this and i appreciate criticism :)
|My first 40K bunker
|by kraggi | Posted Feb 9, 2010
|Here is my first 40k building, made from a shoe box, straws and fixed with hot glue - hope you like it
|My fantasy mine
|by kraggi | Posted Feb 9, 2010
|my first mine made from cardboard with straws, toiletpaper, pva glue
|new terrain made from foam board
|by laurian | Posted Feb 7, 2010
|thanks to miniwargaming's tutorial....comment, rate, enjoy!
|My 11th Game played
|by pinkfr3akz21 | Posted Feb 7, 2010
|kinda an old video just deciding to post it up on miniwargaming though
|Orks vs Space Wolfs 10th game
|by pinkfr3akz21 | Posted Feb 6, 2010
|My 10th game played with my new list, going for the 10game winning streak...
|GAC is still around and Bootleg paintings set is d
|by terrainaholic | Posted Feb 6, 2010
This is a quick shout out about GAC
|Paint job done on Avatar floating bridge
|by terrainaholic | Posted Feb 5, 2010
|This is a quick overview on the avatar bridge and another possible painting style you can apply to it:)!
|40k trenches
|by laurian | Posted Feb 4, 2010
|terrain 4 40k....comment!
|Mordheim Cemetary for Andy
|by terrainaholic | Posted Feb 4, 2010
|This is just a short vid for my Buddy Andy for his Mordeim game coming up:) I hope you have a BALL Bro:)!!!!!


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This video lecture from Gases (F.Sc. First Year Chemistry) covers the definition of Charles's Law, mathematical representation, experimental verification of the concept with the help of examples. The derivation of the Absolute Zero and the graphical explanation of it are discussed in details.. Find more e-learning material and educational video lectures in Urdu at maktab.pk. These videos are free to use for promotional and commercial purpose by keeping the credits to Maktab.


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Have It Your Way: The Big Opportunity in Providing Customizable Products and Solutions
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As Cortex builds our new mission and values, one component has come to the forefront of our minds: community. We strive to develop strong ties to the business community as...Read more
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Before we look at the final factor for developing strong employee engagement, let's first recap why this topic is important. Why is employee engagement critical for your business? It's simple:...Read more
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Andrew Carnegie once said "Teamwork is the ability to work together toward a common vision. It is the fuel that allows common people to attain uncommon results." Collaboration is the...Read more


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Ionic Remodeling of Cardiac Purkinje Cells by Congestive Heart Failure
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Background Cardiac Purkinje cells (PCs) are important for the generation of triggered arrhythmias, particularly in association with abnormal repolarization. The effects of congestive heart failure (CHF) on the ionic properties of PCs are unknown.
Methods and Results PCs were isolated from false tendons of control dogs and dogs with ventricular tachypacing-induced CHF. CHF PCs were hypertrophied (capacitance, mean±SEM, 149±4 pF, n=130; versus 128±3 pF, n=150, control; P<0.001). Transient outward current density was reduced in CHF PCs without change in voltage dependence or kinetics. CHF also reduced inward-rectifier current density, with no change in form of the current-voltage relationship. Densities of L- and T-type calcium, rapid and slow delayed rectifier, and Na+-Ca2+ exchange currents were unaltered by CHF, but L-type calcium current inactivation was slowed at positive potentials. Purkinje fiber action potentials from CHF dogs showed decreased phase 1 amplitudes and elevated plateau voltages and demonstrated twice as much prolongation on exposure to the rapid delayed rectifier blocker E-4031 as control Purkinje fibers.
Conclusions CHF causes remodeling of important K+ and Ca2+ currents in cardiac PCs, decreasing repolarization reserve and causing an exaggerated repolarization delay in response to a class III drug. These results have important potential implications regarding ventricular arrhythmogenesis, particularly related to triggered activity in PCs, in patients with CHF.
Received May 17, 2001; revision received July 20, 2001; accepted July 25, 2001.
Congestive heart failure (CHF) predisposes to the generation of ventricular tachyarrhythmias1 and the occurrence of sudden death.2 In addition, CHF promotes drug-induced Torsades de Pointes arrhythmias.3 Abnormal repolarization, related to ion channel remodeling, is important in the arrhythmogenic potential of CHF.1,4,5
CHF-induced remodeling of ionic currents in ventricular5 and atrial6 myocytes has been studied in detail. Cardiac Purkinje cells (PCs) are believed to play important roles in the generation of ventricular arrhythmias, particularly those related to triggered activity.7–9 Ionic currents are altered in subendocardial PCs in regions of myocardial infarction10–12; however, almost nothing is known about PC ionic remodeling in CHF. The present study was designed to evaluate CHF-induced changes in ionic currents and action potentials (APs) in canine cardiac PCs.
CHF Preparation
CHF was produced as previously described6 by pacing the right ventricle at 240 bpm for 3 weeks followed by 2 weeks at 220 bpm. Dogs were then anesthetized with morphine (2 mg/kg SC) and α-chloralose (120 mg/kg IV load, 29.25 mg/kg per hour infusion), and a median sternotomy was performed. All animal care and handling procedures followed the guidelines of the Canadian Council on Animal Care. Excised hearts were immersed in Tyrode solution at room temperature. Free-running false tendons were excised into modified Eagle's MEM (Gibco-BRL; pH 6.8, HEPES-NaOH) containing collagenase (800 to 900 U/mL, Worthington Type-II) and 1% BSA (Sigma), and single PCs were isolated as previously described.13,14
Standard Tyrode solution contained (in mmol/L) NaCl 136, KCl 5.4, MgCl2 1, CaCl2 1, NaH2PO4 0.33, HEPES 5, and dextrose 10; pH 7.4 (NaOH). High-K+ storage solution contained (in mmol/L) KCl 20, KH2PO4 10, dextrose 10, glutamic acid 70, β-hydroxybutyric acid 10, taurine 10, and EGTA 10; 0.1% BSA; pH 7.4 (KOH). Standard pipette solution contained (in mmol/L) K+ aspartate 110, KCl 20, MgCl2 1, Mg2ATP 5, HEPES 10, phosphocreatine 5, GTP 0.1, and EGTA 5; pH 7.2 (KOH). Solutions were equilibrated with 100% O2.
For K+ current measurement, the extracellular solution included 1 μmol/L atropine to eliminate muscarinic K+ currents and CdCl2 (200 μmol/L) or nimodipine (1 μmol/L, for IK studies) to block Ca2+ currents. Na+ current contamination was prevented by equimolar substitution of choline for extracellular Na+. For currents other than transient outward current (Ito), 1 mmol/L 4-AP was used to block Ito. Rapid delayed rectifier current (IKr) was studied as 5 μmol/L E4031-sensitive current and inward rectifier current (IK1) as 1 mmol/L Ba2+-sensitive current. Slow delayed rectifier current (IKs) was studied in the presence of 1 μmol/L dofetilide to eliminate IKr. For ICa recording, the bath solution contained tetraethylammonium chloride, CsCl, and CsOH in place of NaCl, KCl, and NaOH, respectively, and [CaCl2] was 2 mmol/L. The pipette for ICa recording contained (in mmol/L) CsCl 20, Cs-aspartate 110, MgCl2 1, EGTA 10, GTP 0.1, ATP-Mg 5, HEPES 10, and Na2 phosphocreatine 5; pH 7.2 (CsOH). Na+-Ca2+ exchange (NCX) current (INCX) was recorded with ramp pulses and extracellular (in mmol/L, NaCl 140, CaCl2 0 or 5, MgCl2 1, CsCl 5, HEPES 5, nimodipine 0.001, ouabain 0.01, and ryanodine 0.005; pH 7.2 CsOH) and pipette (in mmol/L, CsCl 90, NaCl 50, MgATP 5, MgCl2 3, EGTA 20, CaCl2 13, and HEPES 20; pH 7.2, CsOH) solutions designed to suppress K+ current, Na+-K+ ATPase, and sarcoplasmic reticulum Ca2+ release.15
Data Acquisition and Analysis
Whole-cell patch clamp was performed as previously described13,14 at 36.5°C. Compensated series resistance and capacitive time constants (τs) averaged 2.5±0.1 MΩ and 290±10 μs. Leakage compensation was not used. The capacitance of CHF cells was increased (149±4 pF, n=130, versus 128±3 pF in control, n=150; P<0.001), so currents are expressed in terms of density.
Standard microelectrode techniques were used to record action potentials (APs). The Tyrode solution contained (in mmol/L) NaCl 120, KCl 1.5, KH2PO4 1.2, MgSO4 0.1, NaHCO3 25, CaCl2 1.25, and dextrose 5; pH 7.4. Purkinje fiber false tendons were superfused with oxygenated (95% O2 and 5% CO2) Tyrode solution at 36°C and impaled with 3 mol/L KCl-filled glass microelectrodes (8 to 20 MΩ) connected to a high input-impedance amplifier.
Nonlinear least-square curve-fitting algorithms were used for curve fitting. Nonpaired t tests were used to compare CHF with control cells. P<0.05 was considered to indicate statistical significance. Group data are expressed as mean±SEM.
Changes in Ionic Currents
K+ Currents
Figure 1 shows representative IK1 recordings (panels A and B). CHF significantly reduced IK1 (C), including the outward component (D), without altering the form of the IK1 current-voltage relation (Figure 1C, inset).
Figures 2A and 2B illustrate Ito recordings from control and CHF PCs. Ito density was significantly smaller in CHF PCs (Figure 2C); however, there were no differences in the form of the Ito-V relation (Figure 2D). The voltage dependence of Ito inactivation was tested with a 2-pulse protocol as described in Figure 2E. Activation voltage dependence was evaluated from the relation ITP=aTPGmax(VTP−VR), where ITP and aTP are current and activation variable at test potential VTP, VR is reversal potential, and Gmax is maximal conductance. Half-maximal voltage (V) and activation slope factor (Boltzmann fits) were 8.9±0.7 and 10.3±0.4 mV (control) and 8.9±1.0 and 10.9±1.0 mV (CHF, P=NS). VR obtained from the reversal of Ito tail currents after 2-ms activating pulses averaged −75.3±2.2 mV. Inactivation V and slope factor were −30±2 and 11±1 mV (control) and −31±2 and 11±1 mV (CHF, P=NS). Ito inactivation kinetics were biexponential, with τs unaltered by CHF (Figure 2F). Ito recovery (Figure 2G) was biexponential, with τs averaging 42±8 and 1391±67 ms (control) and 52±11 and 1486±108 ms (CHF, n=10 for each, P=NS). Ito frequency dependence was similarly unaffected by CHF (Figure 2H).
Figure 3 shows results for IKr (left) and IKs (right). Representative control recordings are shown at the top, with mean step I-V relations, which were unchanged by CHF, in the middle. Activation voltage dependence based on normalized tail currents is shown in bottom panels and was not altered by CHF for either IKr or IKs.
Ca2+ Currents
Representative L-type calcium current (ICa.L) recordings are shown in Figures 4A and 4B and point to slowed ICa.L decay in CHF. ICa.L density was not significantly different between control and CHF cells (Figure 4C). Inactivation τs were slowed significantly by CHF at voltages positive to +10 mV (Figure 4D). For example, at +20 mV, τfast increased from 6.0±0.3 to 8.2±0.9 ms (P<0.05) and τslow from 38±2 to 66±8 ms (P<0.01) in CHF PCs. In addition to a slowing of inactivation τs, CHF significantly increased the proportion of slow-phase inactivation at positive voltages (Figure 4E). For example, at +30 mV, τ2 accounted for 36±4% of inactivation in control PCs compared with 51±5% in CHF (P<0.05). ICa.L inactivation voltage dependence was assessed with a 2-pulse protocol (Figure 4F). Inactivation V and slope factor were −25±2 and −6±1 mV (control) and −26±1 and −7±1 mV (CHF, n=10 cells/group, P=NS). Activation voltage dependence was assessed according to the relation ITP=aTPGmax (VTP−VR), with VR obtained from a linear fit to the ascending portion of the I-V relation. Resulting mean V and slope factors were 2.0±1.4 and 6.6±0.2 mV (control) and 0.4±1.4 and 6.5±0.1 mV (CHF, n=10/group, P=NS). Reactivation kinetics at holding potential (HP) (−80 mV) close to the PC resting potential are shown in Figure 4G. Reactivation was monoexponential, with similar τs in control (44±7 ms) and CHF PCs (53±6 ms, n=10/group, P=NS). ICa.L showed little frequency dependence between 1 and 5 Hz at a HP of −80 mV, and there were no significant CHF-related differences in ICa.L frequency dependence (Figure 4H).
All PCs possessed a relatively large T-type calcium current (ICa.T) (Figures 5A and B). ICa.T was obtained as previously described16,17 by digital subtraction of ICa elicited at HP −50 mV from ICa at a HP of −90 mV. The mean ICa.T density voltage relation was not altered by CHF (Figure 5C). ICa.T inactivation V and slope factors averaged −61±2 and 4.1±0.4 mV (control) and −63±2 and 4.9±0.5 mV (CHF, n=10/group, P=NS) (Figure 5D). Activation V and slope factors were −32±1 and 10±1 mV (control) and −30±2 and 12±1 mV (CHF), respectively (n=10/group, P=NS). The time course of ICa.T inactivation was monoexponential, and there were no significant differences between groups; for example, at −20 mV (voltage of maximum ICa.T), τs were 4.5±0.2 ms (control, n=10) versus 4.6±0.3 ms (CHF, n=10, P=NS). ICa.T reactivation was assessed (Figure 5E) at a test potential (−30 mV) at which no ICa.L is activated (Figure 4C). ICa.T reactivation τs averaged 51±3 ms (control) versus 49±4 ms (CHF, n=10 cells/group, P=NS). The frequency dependence of ICa.T (Figure 4F) was greater than that of ICa.L but did not differ between groups.
Figure 6A shows INCX as determined from current during ramp depolarizations from −60 to +50 mV in the presence of 5 and 0 mmol/L [Ca2+]o. Reverse-mode INCX is substantial in the presence of 5 mmol/L Ca2+ and is absent in the presence of 0 mmol/L Ca2+, allowing INCX to be calculated from the difference between the two current recordings.15 The results in Figure 6B show that INCX amplitude was larger in CHF cells but that after correction for cell size (capacitance normalization), there were no significant differences.
Changes in APs
PC AP characteristics were first recorded at a total of 42 sites from 11 control dogs and 37 sites in 8 CHF dogs at 1 Hz. Phase 1 repolarization was less marked in CHF, and the plateau voltage was higher (Figure 7, top). There were no significant differences in resting potential, AP amplitude, or AP duration (APD) between control and CHF cells, but plateau-voltage was significantly more positive and phase 1 amplitude significantly smaller in CHF PCs (Table).
To evaluate the possibility that the response to an IKr-blocking class III drug may be altered in CHF PCs, APs were recorded from control and CHF PCs in free-running false tendons with standard microelectrodes before and after exposure to E-4031 (1 μmol/L). The results are illustrated in Figures 7C and 7D, and mean data are provided in Figures 7E and 7F. As in the first series of experiments, predrug APDs were not significantly different between control and CHF PCs. However, E-4031 had substantially larger effects on APD in CHF PCs, so that APD95 after the drug was significantly greater in CHF cells at all frequencies (P<0.001 for each). For example, E-4031-induced APD95 increases averaged 103±45 ms (25±10%) at 1 Hz in control preparations compared with 231±40 ms (54±10%) in CHF preparations.
We have evaluated the effects of CHF on K+ currents, Ca2+ currents, NCX, and AP properties of PCs from free-running ventricular false tendons. CHF decreased PC Ito and IK1 density and slowed the inactivation of ICa.L without altering its density. IKs, IKr, INCX, and ICa.T were unaffected. CHF reduced the amplitude of phase 1 repolarization, increased plateau voltage, and enhanced the APD-prolonging effect of E-4031.
Comparison with Previous Studies of CHF-Induced Ionic Remodeling
There have been extensive studies of the ionic remodeling of K+ and Ca2+ channels in ventricular myocytes of patients and experimental animals with CHF.5,18,19 Ito is quite consistently reduced5,20–22 by an average of ≈35% in ventricular myocytes of patients with CHF.18 IK1 also tends to be decreased by ≈25%.18 Although there is some variability in the results for ICa.L,5,23 overall there seems to be no change in ICa.L density or kinetics. Recent studies point to downregulation of IKs and possibly IKr in ventricular myocytes of rabbits with tachypacing-induced CHF.24 Atrial ionic remodeling in CHF has been studied to a lesser extent, but recent studies suggest that Ito, IKs, and ICa are all decreased and INCX is increased, with no change in kinetics or voltage dependence and no change in IK1 or IKr.6
Several aspects of PC ionic remodeling resemble previously reported findings in ventricular myocytes: Ito and IK1 were reduced and ICa.L density was unchanged. These observations suggest that the mechanisms leading to CHF-induced Ito and IK1 downregulation at the ventricular level also likely operate on free-running Purkinje fiber false tendons. The CHF-induced slowing of ICa inactivation that we observed has not, to our knowledge, been reported in ventricular myocytes. We did not observe changes in IKr or IKs, suggesting that PCs may be spared from the IK downregulation occurring with CHF in ventricular myocytes24 and possibly explaining why overall APD was not prolonged in CHF PCs. Unlike typical findings in ventricular5 and atrial6 myocytes, INCX density was not increased by CHF in PCs.
Relationship to Other Studies in PCs
Ito, ICa, IK1, and E-4031-sensitive current have been studied in PCs from the subendocardial Purkinje fiber network overlying 24- to 48-hour-old myocardial infarctions.10–12 Ito density was reduced by >50% in the infarct zone, with no change in voltage dependence but a slowing in reactivation.10 PCs from free-running false tendons had normal Ito properties. Both ICa.L and ICa.T were reduced in subendocardial PCs from the infarct zone, with no changes in voltage dependence or inactivation kinetics.11 IK1 was reduced in PCs from the infarct zone, and a very rapidly activating E-4031-sensitive current was increased, with no classical IK noted in either normal or infarct zone PCs.12 In general, the abnormalities noted in infarct zone PCs were more severe than those we observed. There are, however, some qualitative similarities in terms of decreases in IK1 and Ito. In contrast to our findings, myocardial infarction did not affect the electrophysiology in PCs from free-running false tendons, suggesting that myocardial infarction produces severe but localized ionic remodeling in infarct zone PCs whereas CHF produces more generalized but less severe remodeling.
Potential Significance
The present study constitutes the first detailed analysis of CHF-induced ionic remodeling in PCs. PCs are believed to play an important role in ventricular arrhythmogenesis, particularly in the generation of early afterdepolarization-induced arrhythmias.7,8 The CHF-induced ionic abnormalities we noted in PCs may contribute to promoting the occurrence of arrhythmogenic afterdepolarizations in patients with CHF, particularly in response to interventions such as IKr-blocking antiarrhythmic drugs and hypokalemia that prolong APD. Downregulation of Ito, along with slowed inactivation of ICa, is likely responsible for the positive shift in the plateau voltage of PCs. The positive shift in plateau voltage and slowed ICa.L inactivation at positive voltages would act to promote the occurrence of ICa.L-dependent early afterdepolarizations under conditions that delay repolarization.25
The CHF-induced decreases in Ito and IK1 are likely to reduce the repolarization reserve, the ability of myocardial cells to repolarize when normal repolarizing currents are reduced by drugs, metabolic or electrolyte imbalances, or intercurrent diseases. Consistent with this notion, PCs from dogs with CHF showed twice as great APD prolongation in response to IKr blockade with E-4031 compared with control PCs. CHF significantly increases the risk of drug-induced Torsades de Pointes arrhythmias.3 The CHF-induced ionic remodeling that we observed in PCs could clearly play an important role in this clinically important phenomenon.
Potential Limitations
The isolation of PCs from free-running Purkinje fibers is technically challenging, requiring prolonged periods of bath exposure to cell-dissociating enzymes (chunk method). This likely explains the absence of studies of PC remodeling in CHF, despite the large number of studies that have evaluated ventricular myocyte remodeling. IK is particularly sensitive to isolation technique26 and has been difficult to record in isolated PCs.12,27 We were able to record robust IKs in isolated PCs, but IKr was smaller and more difficult to record; therefore, our results regarding IKr should be interpreted with caution. The properties of the currents we recorded from normal PCs were generally similar to those reported for studies with other preparations; however, we cannot exclude the possibility that cell isolation might have affected the currents we evaluated. Isolation of PCs uncouples them from other PCs and from ventricular myocytes, removing an important modulator of electrophysiologic function present in vivo. This consideration does not apply to the multicellular preparations we studied, which maintain attachments to both false tendon PCs and underlying muscle intact. We measured currents in the presence of heavily buffered [Ca2+]i. [Ca2+]i buffering was necessary to preserve cell viability under our recording conditions; however, CHF-induced changes in [Ca2+]i could importantly affect currents like the NCX. Such changes would not have been detected in the present study.
This work was supported by operating grants from the Canadian Institutes for Health Research and the Quebec Heart and Stroke Foundation. Dr Li was a Heart and Stroke Corporation of Canada/AstraZeneca Fellow. The authors thank Essai and Pfizer Pharmaceuticals for providing E-4031 and dofetilide, Chantal St-Cyr and Chantal Maltais for technical assistance, and Annie Laprade for secretarial help.
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Nuss HB, Kaab S, Kass DA, et al. Cellular basis of ventricular arrhythmias and abnormal automaticity in heart failure. Am J Physiol. 1999; 277: H80–H91.
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Lehmann MH, Hardy S, Archibald D, et al. Sex difference in risk of torsade de pointe with d,l-sotalol. Circulation. 1996; 94: 2535–2541.
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Tomaselli GF, Marbán E. Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res. 1999; 42: 270–283.
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Li D, Melnyk P, Feng J, et al. Effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation. 2000; 101: 2631–2638.
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El Sherif N, Caref EB, Yin H, et al. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome: tridimensional mapping of activation and recovery patterns. Circ Res. 1996; 79: 474–492.
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Berenfeld O, Jalife J. Purkinje-muscle reentry as a mechanism of polymorphic ventricular arrhythmias in a 3-dimensional model of the ventricles. Circ Res. 1998; 82: 1063–1077.
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Jeck C, Pinto JM, Boyden PA. Transient outward currents in subendocardial Purkinje myocytes surviving in the 24 and 48 hr infarcted heart. Circulation. 1995; 92: 465–473.
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Boyden PA, Pinto JM. Reduced calcium currents in subendocardial Purkinje myocytes that survive in the 24- and 48-hour infarcted heart. Circulation. 1994; 89: 2747–2759.
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Han W, Wang Z, Nattel S. A comparison of transient outward currents in canine cardiac Purkinje cells and ventricular myocytes. Am J Physiol. 2000; 279: H466–H474.
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Han W, Wang Z, Nattel S. Slow delayed rectifier current and repolarization in canine cardiac Purkinje cells. Am J Physiol. 2001; 280: H1075–H1080.
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Hirano Y, Fozzard HA, January CT. Characteristics of L- and T-type Ca2+ currents in canine cardiac Purkinje cells. Am J Physiol. 1989; 256: H1478–H1492.
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Tseng GN, Boyden PA. Multiple types of Ca2+ currents in single canine Purkinje cells. Circ Res. 1989; 65: 1735–1750.
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Priebe L, Beuckelmann DJ. Simulation study of cellular electric properties in heart failure. Circ Res. 1998; 82: 1206–1223.
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Kaab S, Nuss HB, Chiamvimonvat N, et al. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res. 1996; 78: 262–273.
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Beuckelmann DJ, Nabauer M, Erdmann E. Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res. 1993; 73: 379–385.
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Tsuji Y, Opthof T, Kamiya K, et al. Pacing-induced heart failure causes a reduction of delayed rectifier potassium currents along with decreases in calcium and transient outward currents in rabbit ventricle. Cardiovasc Res. 2000; 48: 300–309.
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- Ionic Remodeling of Cardiac Purkinje Cells by Congestive Heart FailureWei Han, Denis Chartier, Danshi Li and Stanley NattelCirculation. 2001;104:2095-2100, originally published October 23, 2001https://doi.org/10.1161/hc4201.097134
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Entrance Exam is a series at BuckeyeNation where we chat with incoming freshmen in Ohio State athletics.
Tyvis Powell (Bedford, Ohio/Bedford) knows all about pulling his weight.The 6-foot-3, 196-pound Powell did his share of turning heads -- and tires -- during his high school days at Bedford.
It started with flipping over 250-pound steel-belted tractor wheels in the offseason before his senior season with the Bearcats and it has earned him respect throughout.


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<< TK's MORNING BUZZ: DVD Sales Are the Glimmer in the Future of Home Video | Blog Home | APAR's WORKING WEEKEND: Movie MAFIA -- Marketing AFI Anachronistically >>
TK's MORNING BUZZ: Best Buy's Plans for Musicland's Mall Stores Are Intriguing8 Dec, 2000 By: Thomas K. Arnold
Best Buy's objective, in acquiring more than 1,300 additional storefronts to add to its own 400-plus, is to beef up its presence and avenues for selling cutting-edge digital electronics like DVD players, satellite systems and assorted wireless gadgetry.
Best Buy's immediate target are Musicland's 680 Sam Goody mall stores, as well as another 200 On Cue locations in rural areas. These stores in the coming year will be converted into mini-Best Buys, with their music and video software mix augmented by hardware.
Analysts question whether the transformation will work, maintaining that costs are higher in smaller stores and Best Buy may not be able to carry over its trademark deep-discount pricing and promotions. They also wonder whether Best Buy will have the cash to carry through with its plans, since its own earnings for the second half of this year are off and music sales are flattening after several years of slow but steady growth.
If Best Buy can pull it off, however, then we will see the birth of a truly revolutionary chain of multimedia stores that carry just about everything, albeit in limited quantities, having to do with home entertainment.
This could be a very smart move, in my mind. Best Buy has already established itself as a destination for home entertainment enthusiasts. I personally shop there for CDs and hardware, and I know many video specialty retailers routinely pick up their DVDs and VHS sellthrough cassettes at prices a lot lower than their distributors charge.
If Best Buy can successfully bring its product mix into the malls and thus capture the impulse buyer as well as the destination shopper, then we're looking at something that could truly be big. But as the analysts say, there are compelling questions about whether all of this is even possible.
The home entertainment store of the future just might not fit into a cookie cutter, after all.
Comments? Contact TK directly at:email@example.com


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Suitable candidates are put through further identification checks before we forward you relevant CV's and profiles. When you have selected the candidates you wish to interview, we will arrange interviews on your behalf and deal with administration and negotiation throughout the employment offer.
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|2012-02-02, 06:28
|Link #1
Prefectural Magical Girl
Join Date: Apr 2010
Location: Paris, France
Sekiei Ayakashi Mangatan
Original creator : Takanori Kawai
Plot summary : The story is set during the middle of Japan's historic Edo period. It centers around Sekiei Toriyama, an eccentric but brilliant artist who only draws supernatural creatures because he actually draws the creatures he encounters in his life.
Note : Kawai has been serializing the manga in Weekly Young Jump and later on the magazine's website since 2010, and Shueisha will publish the sixth compiled book volume on February 17. The second of three web anime episodes will debut on February 16, and the final episode will go online on March 1.
|seinen, supernatural
|Thread Tools


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October 1, 2012
Engr. Reynaldo de Guzman
Duale Subd.
Orani, Bataan
Dear Engr de Guzman:
As per customer demand in our recent promo we extend the "BigSale Presyo Package" this October 7 til end of November. We are giving lot of discounts in accessories like computer and laptop and services.
We are inviting everyone to avail our BigSale Presyon Package. We see to it that we give what you have given to us.
If you have any question or inputs that you bought to us please feel free to ask, we serve it anytime. Look for Ferdz.
Sincerely yours,
PC Clinic Computer Shop


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|( 17 upvotes )
|Night you Irish, Mexican!!!
|And just for your curiosity....my purdy mug is not in this pic
|Aggy? You really have to read all the comments on this one buddy!!! To know me now and think back on the comments......it's a riot!!! All the things we've been PM'n aboot is wrapped up in these few posts....the difference between acceptance and timmy...
|A stiff till the end huh? I was actually acknowledging your witty correction and you still can't let up. GED= you "Gotta Enjoy ***k"
|You're gammar b strong agdanieley!! I got a giggle outta the awaaaayyy comment!! And yes they're abunch of mistakes for youre enjoyment wright hear ..buy buy!! Sad part is? I did miss that one and now it's going to be on my...um...what's that word?
|Con-scious: adjective - having the mental faculties fully active. eg: I'm guessing you weren't conscious during English class. Just so you know, it's 'conscience' - and knowing is half the battle. Grammar Nazi awaaaaaayyyyyyyy!
|( 9 upvotes )
|( 50 upvotes )
|smack smack* OI!
|ON the corner....AK works ON the corner.
|You better join AK in that corner.
|So long as Nurse Joy doesn't work for Osama...
|Dammit, this made me chuckle... I'll go sit in the corner now. Sorry.
|( 21 upvotes )
|( 10 upvotes )
Misc info


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OK I want my first kiss with my boyfriend to be in the rain. We have been dating for almost a month. How do I do it? I want it to be special and romantic.
Most Helpful Guy
darling don't say love. Because that's like saying "this is as good as it gets baby" NAH Scratch that idea.
K if your a firm believer in guy making the move (my god I hate how we have make the move)...than just give hints. Look at lips repetitively (not like we do it already), have those Staring moments...just glaring into his eyes...
Though LETS BE HONEST... let the moment arise. don't expect nor not expect it coming. Just let things flow... like in she's the man...
and my god...wanna know a sad story?
i had my first kiss was after 2 months...of dating. We were on the couch, watching jersey shore ISH!...we got on the topic of how I was describing why she was cute, once I had finished, she just looked at me (she has really cute, adorable, amazing, stunning, glowing (Like they had a sparkle...probz because jesus was behind me but what evs)), but from there I just leaned in 50%...moved back 10%...waited to see...than moved in 40%... because we all know the guy should do like over 60% of the leaning...
anywho I guess it's just the look that really set a moment for me.00|00|0


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18. "Mmmmff Sasuke." I squirmed holding him close to me. Somehow after we got something to eat we ended up at my house in my room, snuggling. At least that's what we were doing. Now we were under the sheets fondling.
"Do you find this uncomfortable?" He asked as his hands inched down my jeans skirt. I knew I should've worn jeans today. "N-no." I stuttered snaking my hands up his shirt wanting him to take it off . Sasuke then attacked my neck leaving hickeys up and down my jugular, but now before licking and nipping at it. "Sasuke, how many girls have you slept with?" I asked trying to fight the pleasure he was giving me. It was a random question, yes. But she couldn't help but ask. "Must we talk about this now?" He asked nuzziling his face into my chest before pressing his knee between my legs. I stifled a moan. "Yes, answer me Sasuke." I replied pushing him so that we were face to face. He sighed an


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WASHINGTON (AP) — The latest twist in the touch-and-go efforts to end the NFL lockout: Players didn't vote Wednesday on a full proposal to settle the labor dispute.
The league, however, said the sides would work through the night to try to have a final agreement ready for ratification Thursday.
A person familiar with the negotiations told The Associated Press there was agreement among player representatives from all 32 clubs on what items needed to be resolved before any offer would be accepted. A second person, also speaking on condition of anonymity because the talks are supposed to be secret, said those players gave what was termed "conditional approval" of the proposal — as it stood Wednesday.
Even after all acceptable terms are established, it only would lead to a collective bargaining agreement if the team reps recommend re-establishing the NFL Players Association as a union. And that needs to be OK'd by a majority vote of the 1,900 players. Those votes probably would be done on a conference call.
In March, when talks broke down and the old CBA expired, the NFLPA said it was dissolving itself as a union and instead becoming a trade association, a move that allowed Tom Brady and other players to sue the league under antitrust law. Only a union can sign off on a CBA.
"We still have a lot of work to do," said Pro Bowl offensive lineman Tyson Clabo, who played for the Atlanta Falcons last season.
The meeting at NFLPA headquarters lasted nearly 10 hours and included the group's executive committee and the team reps.
In Atlanta, where the owners' labor committee met, NFL general counsel Jeff Pash said the sides would keep talking in hopes of finalizing a deal that is expected to last 10 years, although even that was not 100 percent certain as of Wednesday evening.
"It's obviously a complicated agreement, but I think both sides are at the point where they can close, they should close, and we should be in a position to take votes," Pash, the owners' lead negotiator, said following a five-hour session at a hotel near Atlanta's airport.
NFL Commissioner Roger Goodell joined the meeting of nine of the 10 members of the labor committee, which hoped to recommend a finalized proposal to all club owners, who are due there on Thursday.
Remaining issues are believed to include how to set aside three pending court cases: The players' antitrust lawsuit against the NFL in federal court in Minnesota; the TV networks case, in which players accused owners of setting up $4 billion in "lockout insurance," money that the league would receive even if there were no games played in 2011; and a collusion case, in which players said owners conspired to restrict salaries last offseason.
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Product Description
You are buying a vintage pair of two Sterling 10″ Triple Candle Candlesticks Candelabras made by Mueck-Cary Co ( in business from 1940- 1950 , then purchased by Towle) in Pattern 1120 or 1122. Each is signed STERLING and 1122, the M with Two Inequality signs or Greater then marks facing each other , they are cement reinforced at the ams not in the base. Wonderful Floral lace border, see picture. Each measures 14″ tall and 13″ wide . One weighs 27.8 ounces and the other 28.05 ounces. A total of 1584 grams! One is perfect the other has a slight bend on the ledge of one holder. Shipping in the U.S is $20.00 and includes delivery confirmation. International express shipping is $62.00 and includes signature confirmation. New York residents please note there is an 8% sales tax. We are an actual Brick & Mortar store located in Fairport NY and we welcome local pick up. We can also arrange payment with a credit card, please contact us if that is your preferred method of payment. Thank You!


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Anodea Judith's Sacred Centers
Sacred Centers is a teaching organization founded by Anodea Judith in 1999. It quickly became a community of individuals (Co-Hearts) dedicated to deeper personal growth on all levels, and diverse cultural healing and evolution.
Our community forms organically from the workshop experience and the desire to keep that feeling alive long after the class has ended.
Students and graduates of the Sacred Centers Certification Program form Sacred Kin-doms in their own areas, where they conduct healing practices, teach classes and workshops, or hold special community events. So the time spent with us, whether through certification training, a live workshop, a virtual teleclass, or an intensive retreat, maintains itself effortlessly in our daily lives, staying with us and enhancing the sacred within.
In this way, Sacred Centers' kin-doms become self-organizing centers for the coalescence of consciousness, illuminating the sacred web of life for the purpose of bringing together the imaginal cells of the emerging paradigm.
Our Mission
Anodea's goal has always been to promote sacred knowledge for the transformation of individuals and culture. The name Sacred Centers refers to the divine center within each one of us, to the seven major energy centers known as chakras, and to the need to be centered in the sacredness of our daily lives.
The Vision of Sacred Centers is first and foremost to restore connection to the sacred. Too many of us have lost touch with the invaluable resources we hold within.
By re-learning to ground and center yourself, by returning to spiritual practices such as yoga, meditation, healing, ritual, trance, poetry, art, music, and dance, and by allowing ourselves to focus within, we can achieve deeper contact, understanding, and living. We can enjoy the benefits of a powerful reconnection with ourselves, each other, and the grand web of life.
At Sacred Centers, we feel that training yourself to dig deep into the within and tapping into the sacred space there, we inform all other actions in the mundane world, rendering them them more meaningful and effective in our everyday lives.
We do not endorse or condemn any particular religion. We believe that there are many paths to the sacred that are viable for different individuals and cultures. While the chakras come from the yoga tradition of India (see history) they are universal centers that exist within all of us, regardless of race, creed, color, gender, or any of the many isms that contribute to a sense of separation. Instead, this universal system can be embraced and practiced through any religious framework.
At a time when the world seems to be falling apart, we seek ways to come together, to find our common ground, our universal spirit, and contribute to an awakened global heart. The Sacred Centers can give you the tools you need, both physically and emotionally, as well as a liked-minded community of Co-Hearts to explore the vast possibilities through a myriad of workshops, teleclasses, retreats, and summits, reaping the many benefits that come from reconnecting and celebrating the sacred sources within.


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How'd your weekend go? Contrary to what you might assume, there's a very good chance it went better than Justin Trudeau's did. The popular Canadian prime minister is widely regarded as having stepped in it this week, following the death of Cuban revolutionary and decades-long dictator Fidel Castro.
In response, Twitter has fought back with mocking hashtag.
When a world figure as towering as Castro dies, it falls to other leaders across the globe to figure out how to respond. And this is a rather touchy case, given the wildly varying opinions and views of Castro's legacy across the political spectrum—lauded by some for his anti-imperialism, anti-colonialism, and socialist systems of health care and education, while loathed and reviled for his severe human rights abuses and violent repression of his people by others.
Managing that balance can be tricky, especially if you're a head of state, but it's not impossible.
That was not the route Trudeau decided to go. To the contrary, while many Cubans and Cuban expatriates were celebrating the news, he released what's been regarded by many as an ahistorical white-washing of Castro, a statement which expressed "deep sorrow" at the news of Castro's passing and offered the Castro family condolences "on behalf of all Canadians." Here's the full statement.
It's fair to say that a lot of people on social media found this statement a little—or rather, a lot—softer and too fond for their tastes, which gave rise to the hashtag #TrudeauEulogies. It imagines other casual, familiar obituaries by Trudeau about other blood-stained dictators or leaders throughout history (or fiction, too).
Suffice to say, Trudeau's taken quite a vicious online roasting since releasing the statement. He did clarify it Sunday, however, when CBC reporter Catherine Cullen asked him whether he considered Castro to have been a dictator.
This may be a case of damage done, however. All the derision and criticism Trudeau's been absorbing over the past 24 hours, he may simply have to take it. It's a lesson, ultimately, in just how tricky being a national leader can be—however reasonable or measured something might sound when it's read off a page, it's not always going to be received that way. Much less when it downplays some of the most grievous deeds carried out by a dictator who ruled for nearly 50 years.


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Do me a favor, don't leave a comment here – go on over here. I'm really trying to get our church to latch onto this idea of communication.
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yet another extremely popular sport activity and so forth of Rafael Nadal and Serena Williams are probably the faves in many key tournaments. Was it a genuine. The Vikings certainly looked it while lighting up the Saints. Coming off a loss in the Super Bowl, the Falcons are hoping to …Read More »
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Fourth Of July is a band of brothers who make lyrical, raucous Folk Rock about the minefields of love, flyover country existentialism and the boozy social life of their hometown of Lawrence, Kansas. Winner of 2oo7 and 2010 'Best of Kansas City: Best Album' awards from the KC Pitch, Fourth Of July has toured the Midwest and East Coasts, played CMJ and was reviewed by Pitchfork.
Their first two records — 2007's "On The Plains" and 2010's "Before Our Hearts Explode!" were released on Range Life Records. Their third LP, "Empty Moon" is available on Vinyl, CD and Digitally from High Dive.
Fourth Of July's Brendan Hangauer is also the man behind the band Empty Moon, whose debut "The Shark" was released in 2014 on High Dive.
Fourth Of July: Brendan Hangauer (vocals, guitar) Patrick Hangauer (bass) Brian Costello (drums, vocals) Brendan Costello (guitar)


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I've been involved in different sports both in and out of school for my entire life, and the different aspects of sports have changed and shaped my life in many ways. Sports taught me about commitment, what it means to be a part of a team and to have a group of people who are dependent on me. I couldn't just skip out on practices because by joining a team, I had made a commitment to my teammates, my coaches and to myself, and if I broke that commitment, I would be letting all those people, as well as myself, down.
Sports taught me how to set and achieve goals and how to work for what I want. When I ran track in school, I always wanted to beat my time from the year before, but I knew that I would have to practice harder and run more than the year before.
As I've progressed in my sporting career, I've also learned that sometimes we don't achieve our goals, sometimes things don't go as planned, sometimes we fail. Sports have taught me how to pick myself up after failure and that when things get tough, sometimes simply not quitting can be enough.
Sports have taught me to see my body as something strong. I no longer see big as bad. As my legs and butt grow larger, I get stronger, and as I get stronger, I get faster. I see my body less as a subject of someone else's gaze and more as something that is mine, that is strong, and that allows me to do incredible things.
I'm a somewhat anxious and introverted person, but I found it extremely helpful, especially as a teenager, to be involved in a sport where I had to be around a group of people who were all in the same situation, in a controlled environment. Through sports, I made friends and I became more comfortable in social situations outside of sporting activities, too.
Sports have changed and shaped my life. I've made incredible friends that I never would have met if we weren't a part of the same team. I've learned to work through the tough stuff and to commit and work towards my goals. Even just joining a team for one summer could open you up to new friends and new experiences, and there's nothing quite like getting some of your frustrations and stress out in a controlled way on the field, right?
Sports Taught Me That My Big Body Is Beautifully Strong
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text: Check out the "Whip My Hair" star's debut record. The tiniest member of the Smith household has dropped her full debut LP, unannounced. After four years of stony silence, following her surprisingly incredible first single "Whip My Hair", the 15 year old Roc Nation artist Willow Smith has released a full album, including tracks entitled 'dRuGz' and 'Natives of the Windy Forest'. Naturally. Impressively, the daughter of Will and Jada Smith has written the majority of the album herself. You can stream the entire record on Spotify, or purchase it on iTunes. Stay tuned for our thoughts on the record. Are you whipping your hair back and forth to the sound of Willow's new music?