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Shopping for Large Shoes
Shopping for Large Shoes
I don't know if these forums are the right place to be asking this, but I thought I'd try.
Does anyone know a spot in Bangkok where you can buy large (US Size 14) shoes (sandals of a good quality, not something that will fall apart) for men?
#1 Whispy has been a member since 10/1/2012. Posts: 7
I've also been cursed with big feet. Though, I can usually fit my feet snuggly into a size 45-46. Even those sizes can be difficult to find around Bangkok.
Usually, if you don't mind paying the full (normal) price, you can find bigger sizes at most of the Central Stores in the Sports/Shoes sections. A perk, even, is that many people in the area don't buy these bigger shoes; therefore, you can sometimes find a new, brand name pair at a discounted rate. I've found pairs of Nikes and Adidas - Size 12 - for around 1000B ($30) in the past.
Otherwise, you can take your chances at some of the outdoor markets. They will be much cheaper here, but it may be harder to track down a larger pair. If you go to Mo Chit station on the weekend, and then to Chatachuk Market, you may be able to track down a cheap, larger pair if you look around.
#2 n8sand has been a member since 18/12/2010. Location: United States. Posts: 13
Send n8sand a private message
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subset: commoncrawl


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Note: Supplemental materials are not guaranteed with Rental or Used book purchases.
Purchase Benefits
What is included with this book?
|The Cellular Basis of Life
|What is Life?
|The Chemistry of Life
|The Dynamic Cell
|The Energy of Life
|How Cells Release Energy
|The Molecular Basis of Life
|DNA Structure and Replication
|The Cell Cycle
|Sexual Reproduction and Meiosis
|Patterns of Inheritance
|Chromosomes and Human Inheritance Patterns
|Gene Function, Gene Regulation, and Biotechnology
|The Evolution of Life
|The Forces of Evolutionary Change
|Speciation and Extinction
|Evidence for Evolution
|The Origin and History of Life
|The Diversity of Life
|Viruses and Simple Infectious Agents
|Bacteria and Archaea
|Animals I – Invertebrates
|Animals II – Vertebrates
|Plant Life
|Plant Form and Function
|Plant Nutrition and Transport
|Reproduction and Development of Flowering Plants
|Animal Life
|Animal Tissues, Organ Systems and Homeostasis
|The Nervous System
|The Sensory System
|The Endocrine System
|The Musculoskeletal System
|The Circulatory System
|The Respiratory System
|Digestion and Animal Nutrition
|Regulation of Temperature and Body Fluids
|The Immune System
|Animal Reproduction and Development
|The Ecology of Life
|Animal Behavior
|Communities and Ecosystems
|The Biosphere
|Conserving Biodiversity
|Table of Contents provided by Publisher. All Rights Reserved.


text:
Commanding Views and Superb Location
Commanding views of the Willamette river, mountains and Portland skyline, combined with a superb location within Johns Landing, The Landing condominiums are among the very finest waterfront communities in Portland. Noted for it's amenities, proximity to walk/bike paths, dining, parks, recreational activities and public transportation, The Landing Condos offer an unmatched lifestyle. The photo gallery below includes Johns Landing landmarks and neighboring condo complexes.
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text:
Camarillo, California (PRWEB) June 25, 2013
Interlink Electronics, Inc. (OTC: LINK) announced today that Desko GmbH has integrated Interlink's MicroNav 360 Module, "mouse" pointing module into several International Airport Service Terminals in Asia, USA and Europe. They have also been deployed at several German national banks.
As a high-end hardware provider for automatic data readout and data entry devices, Desko develops innovative solutions from passenger processing, border control & immigration, security & POS to public administration. Their reliable entry-level devices target various industries, and they are individualized and upgraded by modular options for several applications. These solutions can be stand-alone - or integrated at time of installation.
MicroNav 360 module is another Interlink Human Machine Interface ("HMI") device consisting of a finger-actuated "mouse" pointing module that provides complete 360-degree directional control and accurate speed control simultaneously. It is ideal for computer cursor control in rugged mobile computers, hardened keyboards, navigation systems, machine control panels, pan and tilt controllers, motion controllers, CNC controllers and medical control equipment. MicroNav 360 Module is a durable, maintenance-free "miniature" solution that works well in tight spaces and is capable of delivering "mouse" lifetimes of more than 3 million actuations. An integrated sealing rib also makes it possible to seal to IP65 hermetic-sealing standards during installation.
"Compact devices and flexible modules are very important for our clients", says Bruno Geyer, Managing Director DESKO GmbH. "Especially at Check-In and Boarding Counters with less desk space, our customers require flexible integration and smart, space-saving equipment. Interlink's MicroNav 360 Module met these requirements for our recent installations of keyboards that are being used at International Airports in Asia, USA and Europe and at several national German banks."
"At Interlink we are constantly striving to provide HMI solutions that meet or exceed our customers' expectations and specifications," said Steven N. Bronson, the Chairman and CEO of Interlink Electronics. Mr. Bronson continued, "We are delighted that our compact, robust MicroNav 360 module met the stringent requirements for these service terminal applications."
For more information about Desko`s applications visit:http://www.desko.de/
About Interlink Electronics, Inc.
Interlink Electronics is a world leader in the design of patented Force-Sensing Resistor (FSR®) technology. For over 28 years, Interlink Electronics' solutions have focused on handheld user input, menu navigation, cursor control, & other intuitive interface technologies for the world's top electronics manufacturers. Interlink Electronics has a 16-year track record of supplying human machine interface (HMI) solutions for mission-critical and rugged applications.
With numerous patents around the world protecting its technologies and products, Interlink Electronics serves a world-class customer-base from its corporate headquarters in Camarillo, California and offices in Japan, Hong Kong and China. For more information, see http://www.interlinkelectronics.com.
This release contains forward-looking statements that involve a number of risks and uncertainties. The following are among the factors that could cause actual results to differ materially from the forward-looking statements: historical losses and negative cash flow, the success of business divestitures and acquisitions, the ownership of the majority of our stock by a small group of investors, our success in predicting new markets and the acceptance of our new products, efficient management of our infrastructure, the pace of technological developments and industry standards evolution and their effect on our target product and market choices, the effect of outsourcing technology development, changes in the ordering patterns of our customers, a decrease in the quality and/or reliability of our products, protection of our proprietary intellectual property, competition by alternative sophisticated as well as generic products, pending litigation against Interlink, historical weaknesses in internal controls over financial accounting, the continued availability at competitive prices of raw materials for our products, disruptions in our manufacturing facilities, risks of international sales and operations including fluctuations in exchange rates, compliance with regulatory requirements applicable to our manufacturing operations, and customer concentrations. The forward-looking statements contained in this release should be considered in light of these risk factors.
Interlink Electronics
For Investor Relations:
Steven N. Bronson +1 805-484-8855 ext.112
For information on MicroModule 360:
Paul Kelley, +1 805.436.0271
Global Sales Manager
For more information about Desko:
DESKO GmbH
Gottlieb-Keim Str. 56
D-95448 Bayreuth
Barbara Lugert
Internal Sales Manager
Ph: +49 921 79279 16
Fax: +49 921 79279 14
http://www.desko.de | barbara(dot)lugert(at)desko(dot)de


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I am a games creator who can work in flash quite fluently... I like games!
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Concentration 2. Rated Stars In this game you must attempt to complete each puzzle using the small information you have Puzzles - Other Concentration. Rated Stars In this game you must attempt to complete each puzzle using the small information you have Skill - Other Astro Words Rated Stars In this space themed game you have to spell the words correctly by using the arrow keys. Bouncy Bouncy Rated Stars In this game you have to get the ball to the creature by drawing a forcefield. Skill - Other


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This Week's Corrupt Cops Storiesby Phillip Smith
Nov. 14, 2013
David Hogg: NRA Are 'Pathetic F--kers That Want to Keep Killing Our Children'
Republican & Democrat Establishment Unite to Shaft America With $1.3 Trillion Omnibus Bill
Lib Freaks Out After Virtue Signalling Poll Backfires
Putin: Germans Should Not Be Forced to Hate Themselves Over Their Past
Unhinged Samantha Bee to Hope Hicks: 'F--k You,' 'You Helped Burn Down Democracy, Bitch!'
A dirty cop in Philly costs convictions, two abusive Border Patrol agents get sent away, and we have a trifecta of crooked jail guards. Let's get to it:
In Philadelphia, a state court judge threw out 53 convictions tainted by a corrupt cop last Friday. Common Pleas Supervising Court Judge Sheila Woods-Skipper threw out the convictions, which involved former Philadelphia police officer Jeffrey Walker, who was arrested by the FBI in May on charges he plotted with a government informant to rob drug dealers. In at least one incident, Walker stopped a suspect's vehicle, planted drugs, and then arrested the suspect. He and a confederate then stole $15,000 from the man's house. The city is also paying out massive settlements in lawsuits bought by Walker's victims, including many who served prison time after being framed in court, they claimed.
In Donaldsonville, Louisiana, an Elayne Hunt Correctional Center guard was arrested last Thursday on charges he was trying to smuggle drugs into the jail. Daron Toussant, Sr. was the object of an internal investigation at the jail, which led to a search of his home, which in turn led to the seizure of marijuana, synthetic cannabinoids, and a handgun. He is charged with possession with intent to distribute marijuana, possession with intent to distribute synthetic cannabinoid, illegal carrying of a weapon, and conspiracy to introduce contraband to a penal facility.
In Hollidaysburg, Pennsylvania, a Blair County Prison guard was arrested last Saturday after being caught bringing drugs to work. Fred Zigler, 27, went down after showing up with Oxycontin, Oxycodone, and acetaminophen tablets. He is charged with possession with intent to deliver and other drug charges.
In Charlotte, North Carolina, a Charlotte Correctional Institution guard was arrested Tuesday after investigators in an unrelated case saw him selling pain pills to another man. Brian Paul McAvoy, 28, was arrested at work, where he was found to be carrying a pain pill. He is charged with sale an delivery of a controlled substance, introduction of contraband into a correctional facility, and possession of drug paraphernalia.
In Tucson, Arizona, two former Border Patrol agents were sentenced Wednesday to serve two years each in federal prison for mistreating suspected marijuana smugglers. Former agents Dario Costillo, 25, and Ramon Zuniga, 31, went down for a 2008 incident in which they descended on a smugglers' encampment in the desert, but only managed to capture four of 20 smugglers. They forced the unlucky men to chew handfuls of marijuana and flee shoeless into the chilly desert. They were convicted of violating the four men's civil rights. Castillo was looking at up to 40 years and Zuniga, who was convicted of misdemeanors, was looking at up to four years.


text: 000 FGUS83 KTOP 070940 RVSTOP KSC027-071740- Hydrologic Statement National Weather Service Topeka KS 440 AM CDT Sat Oct 7 2017 Water levels will approach flood stage for the following streams: Republican River. For the Republican River at Clay Center, the latest stage was 11.9 feet at 4 AM Saturday. Flood stage is 15.0 feet.The maximum stage forecast is 14.9 feet early Sunday morning. Later statements, possibly warnings, may be issued as additional information becomes available. Additional weather and stream information is available at www.weather.gov/top/. $$


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Having problems with your Hoover SteamVac F5914-900 SpinScrub Upright Vacuum ?
I have a hoover steamvac model # F5915-900 and the brushes are not turning when I turn the selector from off to low or high. I've checked to make sure the brushes are locked in place and they turn manually with no resistance. What else can i do?
Answers :
(1) Remove the brush assembly by pulling/unlatching it from base on each side.
\015\012(2) Does one of the brushes have the drive pin present? It should be about ¼ inch square, and two inches long. It attaches the brushes to the drive mechanism.
\015\012(3) Remove and clean the intake filter. One the base of the cleaner, behind the brushes, squeeze the two red abs together and pull the panel down to access the screen. Clean the hair/debris off the screen and reassemble.
\015\012(2) Does one of the brushes have the drive pin present? It should be about ¼ inch square, and two inches long. It attaches the brushes to the drive mechanism.
\015\012(3) Remove and clean the intake filter. One the base of the cleaner, behind the brushes, squeeze the two red abs together and pull the panel down to access the screen. Clean the hair/debris off the screen and reassemble.
Repair Help & Product Troubleshooting for Hoover SteamVac F5914-900 SpinScrub Upright Vacuum
Tips for a great answer:- Provide details, support with references or personal experience .
- If you need clarification, ask it in the comment box .
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Suggested Questions/Answers :
I have a hoover steamvac model # F5915-900 and the brushes are not turning when I turn the selector from off to low or high. I've checked to make sure the brushes are locked in place and they turn manually with no resistance. What else can i do?
(1) Remove the brush assembly by pulling/unlatching it from base on each side.\015\012(2) Does one of the brushes have the drive pin present? It should be about ¼ inch square, and two inches lo ... Hoover SteamVac F5914-900 SpinScrub Upright Vacuum
My Hoover Whisper Cyclonic is collecting the dirt but not taking it into the cylinder. The brushes were at one point starting and stoping due to the belt periodically turning,now the brushes are turning and the dirt just collects and I'm starting to smell a an oder like rubber burning.I've taken it apart and tried to make sure the is no clog. The one hose that I can't check is in the back right base, above and left of the right back wheel.
... Hoover U5753-900 WindTunnel Bagless Upright Vacuum
I replaced the belt on my Dirt Devil Featherlite Bagless Vacuum and the brush roller rubs and makes a very loud noise when turned on. I have gone exactly by the manual instructions and made sure the belt and end caps were on correctly, but the bristles still rub the back and it makes a very loud noise. Without the brush roller in the vacuum, it sounds and runs normal. What could the problem be?
Http://www.geeksquad.fixya.com/ThreadView.aspx?prdid=0&thid=561283\015\012Generic problem for all Vacuums\015\012I replaced the belt on\015\012Posted by piggyt ... Vacuums
Scrubbing brushes I have cleaned the filter, checked the dial to make sure it is turned to high and cleaned all of the brushes. Still I can't get the brushes to rotate. What now?
Your turbine might need to be replaced ... Hoover F5881-900 Vacuum
I have a Dyson DC14 It started making a high pitched squeel so I took the filters out and cleaned them and i checked all places that pull out on the vacume to see if there was anything clogged. I also cleaned the roller brush. but when I turned it on, after a couple of seconds the sound came back again. can you help
Sounds like motor bearings are gone .... sorry. ... Dyson Vacuums
The vacuum is making a noise like something is stuck when it is in the carpet position but not when in the floor position. I can't find anything that is stuck in the areas that I can see. I have cleaned the brush but it does not seem to want to turn. Does this machine need to be oiled so the roller will turn? Is there a way to check inside the motor? Do you think that because the brush won't turn that is making the noise? Do you know of any repair shops in the Lake Havasu City, Arizona area?
As far as the roller brush goes, yes, it does need to be cleaned. Follow the directions to remove it and clean as best you can of all debris. On both ends of the roller brush there will be two "holders" of sort that connect the brush to the frame o ... Dyson DC07 Bagless Upright Cyclonic Vacuum
My Dyson DC 14 is making the horrible "ratcheting"sound only when the brush is engaged on the carpet setting. I have cleaned the brush, so there are no obstructions, the canister is empty and properly on the unit. I checked to make sure all of the "traps" and hoses are clear of obstructions, the belt is on the brush securely and moves freely, the brush itself spins freely, but there is still the "ratcheting" noise. Any other suggestions?
Our DC33 was making the same ratcheting sound immediately upon placing the cleaner/brush head on the carpet. We carefully pulled the beater/brush bar out of the vacuum. Once removed, we pulled the black plastic end off of the center rod. We discovere ... Dyson DC14 Animal Bagless Upright Cyclonic Vacuum
Brand new Hoover Max Extract Deep Cleaner brushes won't turn. Read manual. Checked filters - all clear. Set Spin Scrub Mode Selector to a scrub setting. Brushes still won,t turn. However the brushes on the Spin Scrub hand tool rotate.
... Vacuums
My bissell 82h1 has developed a very loud clattering noise. I cleaned the brushes and checked everything I could easily access to no avail. When I turn it on with the brush removed, the sound level is normal. With the brush in place, I can easily turn it by hand with no indication of it hitting anything.
... Bissell 82H1 Cleanview Helix Bagless Upright Vacuum
Have Hoover F7452900 spin vac carpet shampooer and brushes won't spin. The screen by the brushes is clean and they are place in position to clean on carpet. I noticed that when I have the brushes out of the machine and turn it on that the white square that is on the base of the machine does not spin--this is where part of the brush connector fastens to make bristles spin.
... Hoover SteamVac F5914-900 SpinScrub Upright Vacuum
I have a problem with my model 6585-3 bissell upright powerforce bagless turbo with turbo brush vacuum The brush has quit spinning upon removal i noticed that one side of the brush was free to spin the other side that has the rectangular piece to help hold into place seems to be locked up and will not spin is it corroded or have i lost a piece that joins with it that allows it to spin freely belts are good and motor is turning brush will not budge
... Vacuums
Weird noise i have a eureka the boss and i am getting a weird noise figured bag was full needed to change it so i did. Noise persisted so i checked make sure nothing was caught in the brushes. I even checked the belt it was fine replaced with a new one.Still the noise is there help me I am out of what else to check.
Squealing ... Vacuums
Dyson dc07 The rotating brush on the bottom of my vacuum was filled with strings. I removed the brush by undoing all yellow plastic screws from plate. Removed all strings and replaced as best I could and it was hard to get the brush back in and the belt around it. I dont have my manual but it fits so it should be correct....? Right? No, not true, because when I turn it on and try to and vacuum (by lower canister with foot release) it makes that terrible ratching sound). Please help
The loud ratching is a warning to tell you that there is something stopping the roller bar from rotating this is a very common thing lay the machine on the floor front side down take off the bottom plate and just check the belt is in the centre of th ... Dyson DC07 Bagless Upright Cyclonic Vacuum
My Dyson DC28 works fine for a minute then it's like if the brush head gets too much resistance it quits spinning and the light starts flashing. When I turn the vacumn off then back on it's f
Hi Gayle,I'm sorry to hear you're having difficulties with your DC28. From what you've described, it sounds as if you may have the brushbar set at a level too low for the type of carpeting you're cleaning. If you select a higher carpet settin ... Dyson DC28 Animal Bagless Upright Vacuum
Won't start. My son was using the vacuum & Didn't change the bag. The vacuum was making the full bag smell, but the light was't on & it didn't stop. I stopped him, changed the bag, checked the filter, closed the compartments & turned on the vacuum. Nothing happened. I checked to be sure that it was plugged in, that wasn't the problem. I've let the vacuum "rest" for several days, It still won't start. Any suggestions?
There is a reset button at the back of the powerhead. The user manual can be downloaded from the electrolux website, although I didn't find it very useful. There was some info on how to change the powerhead drive belt. ... Electrolux EL7020A Oxygen 3 Ultra Canister Vacuum Cleaner Bagged Vacuum
I took the cover off the brush so I could cut off all the hair that was wrapped around it (vacuum was working fine, I just noticed the hair). I pulled the brush/spinner thing off one side, cleaned everything, popped it back in where it belonged, and tried to make sure the belt was in the proper alignment. However, when I turned the vacuum on, it makes a horrible noise like I'm sucking up rocks. What have I done wrong in putting it back together? It seemed simple...
The ends of the brush roller have to go in in a certain position.each end has a different look.make sure the match up to the seats on the roller guides and make sure the belt is centered.the belt will center itself by turning the roller by hand in on ... Dyson DC14 All floors Bagless Upright Cyclonic Vacuum
My Kenmore canister model (116) 26212601 works in hard-surface mode (basic suction), but the brush won't spin for carpets, and when I try to turn it on, it makes a whiny sound and then turns off as it does when I need to press the overload button. I looked inside a bit, and the belt isn't broken--it seems fine. So not sure what the problem is. Thanks for any help.
... Kenmore 27815 Bagged Canister Vacuum
My hoover carpet cleaner does not extract water. The brushes stopped turning since more than a month and now it doesn't extract any water. The engine is turning on but it does not work properly. I've checked for the solutions to this problem in the manual but any of the causes listed there apply to my machine. Thanks for your help.
... Hoover F5826-900 SteamVac Upright Wet Washer
Have you made sure that the tanks are seated properly and the red \012(or black) auto-load gaskets are in place. \012Check the bottom of the Water Tank and the Formula Bottle to make \012sure each has a red auto-load gasket attache ... Bissell 9500 ProHeat 2X CleanShot Upright Deep Cleaner, Red Berends Vacuum
Hi my proheat bissell 7901 stopped pumping water to the floor, but it pumps water from the hand hose. I read the manual and followed how to check belt and the flat belt on right side of shampooer is fine and I turned on and it turns and so do the brushes at the bottom of the machine. I was reading online and I guess there's two belts on this machine? where can I find the other belt to see if it needs replacing. I guess it's a ribbed belt? that is the water pump belt?
Just taken ours apart with the same problem... found it was caused by the 2 halves of the main casing coming apart in the area where the upright pedal release is. I found this to be due to the upper casing having broken in 2 places - the bottom of th ... Bissell 7901-1 ProHeat Scotchgard Upright Wet/Dry Vacuum
Bissell Proheat I have a Bissell ProHeat 12 amp 6 cleaning brush upright and it won't turn on anymore. We have done the basics like making sure the outlets work, etc. Changed it around to different outlets. It is not turning on. Any idea?
Things to check are the cord, switch, and the motor. ... Vacuums
Cleaning solution does not come out of the rotating cleaning head or the hand-held nozzle the solution pump seems ok but does not run (electrical continuity check between the two leads on the pump show very low resistance so they seem to be intact) - no dirt or blockage is apparent (it is a very simple device with 1 moving part wires to the pump also pass a continuity check THERE IS NO VOLTAGE on the pump leads from the control circuit board when I turn on the "manual" cleaning mode - a
You can contact Bissell directly at the following\015\012\015\012For UK inquiries:\015\012Monday - Thursday 9 am — 5 pm\015\012Friday 9 am — 4 pm\015\012\015\012BISSELL Homecare (Overseas) Inc ... Bissell SpotBot Robotic Wet/Dry Vacuum
No suction I have new belts. Everything is clean. No clogs. When I turn it on it smells like rubber , the brush doesnt spin. Everything seems to be free flowing.. Roller brush isnt stuck on the ends. Took off hose to make sure no clogs anywhere. There is not even suction thru the hose with the handle in upright position.
Generally, the problem is that the belt is not running the brushes. This is caused by one of the following:\015\012\015\012\015\012beater brush is jammed. This is either an object stuck in the brush or im ... Hoover U6437-900 / U6439-900 Windtunnel Bagged Upright Vacuum
My Bissel proheat carpet cleaner wont spray out of the bottom or the spray handle. I took of the scrub brushes and off and cleaned out the bottom of the machine including popping out the two spray heads to make sure they were not clogged. Put it back together. Still no spray! I also did the turn off, remove fluid containers, replace, turn on for one minute to prime the pump, and still so spray...does this mean my pump is not working?
... Bissell Carpet Cleaner Powerbrush Deep Cleaner Vacuum
When I flip the switch on my sebo x1 upright, a red light comes to the brush and bag icons. However, I cleaned out the hose and checked to make sure there is no obstruction from the brush to the hose also, or from the hose to the bag. It is clear that juice is coming to the vacuum, but there is no sign of life except the two red lights.
Thanks for contacting fixya. You should pull out the bag and reset the machine. You should take all the user replaceable items. And turn it on. You will get lot of errors. Then turn the machine off. Put back all the accessor ... Sebo Automatic X1 Bagged Upright Vacuum


text:
'Xcell Partners did a great job. As a result of Dianes work in one area we re thought our overall strategies and changed some previous decisions – very thought provoking. Direct, non-political and to the point. Will be using her services again.' – Mick Daw, Managing Director PrisymID
'Diane was instrumental in setting up some key meetings for us during a recent business trip to San Francisco and it is clear to us that she is well respected in both the local and international business community. As a mentor, Diane has a rare blend of IT, business and social skills that has definitely impressed both Shane and I and hopefully 'rubbed off' on us! An honest, passionate and fun person – Diane is a pleasure to work with.' – Anthony Keiran, CTO / Founder Media Lightbox
'Not only did Diane provide excellent advice and direction during our initial US market analysis but she gave us outstanding strategic support and network reach as we developed our Americas business. The result was a multi-million dollar US presence within 18 months.' – Vincent Ryan, Executive Vice President Changing Worlds
'Diane has been a trusted advisor to Openet and helped us establish some key relationships. She is very commercially focused.' – Niall Norton, CEO, Openet Telecom Group
'Diane approaches problems and solutions in an efficient and intelligent manner. She is a driven contributor always striving to exceed the business' stated goals. Her proactive approach to clients and their customers is always professional, courteous, and solution focused. Diane's knowledge, experience and insight ensures successful mandates and compelling strategies that produce measurable results for any business. I highly recommend Diane.' – Don O'Brien, CEO Dontel Consulting Inc.
'I've worked with Diane on several projects over the years, and believe that she is one of the most organized and well-connected people around. She's been helping other entrepreneurs develop customers, contacts, and funding — and she's got the brains and judgment to help them win.' – David Taber, CEO, David Taber & Associates, Inc.
'I've worked with Diane and her company Xcell Partners on a number of client-centred projects; I've always found her to be focused on results, alongside being both creative and supportive in her execution.' – Jonathan Akehurst, Marketing Director, Optimum Results


text:
KDE 4.3.1 Released
A month has passed since the release of KDE 4.3.0, so today the KDE Community announces the immediate availability of KDE 4.3.1, a bugfix, translation and maintenance update for the latest generation of the most advanced and powerful free desktop. KDE 4.3.1 is a monthly update to KDE 4.3. It ships with a desktop workspace and many cross-platform applications such as administration programs, network tools, educational applications, utilities, multimedia software, games, artwork, development tools and more. KDE's award-winning tools and applications are available in more than 50 languages.
KDE 4.3.1 is dedicated to Emma Hope Pyne, the daughter of Michael Pyne. Emma Hope suddenly passed away last week. The KDE community feels incredibly sad about this loss and wishes Michael and the family and friends all the strength needed to cope with the loss of Emma Hope.
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text:
2014 is off to an exciting start and I didn't see any of it coming.
Tomorrow I'm about to say a huge "HELL YES" to joining the Alive Tribe – a creative collective of ambitious entrepreneurs setting out to discover just how far we can push ourselves over the next 6 months.
We'll evaluate every aspect of our lives, create game plans for growth, ideate for our projects, and connect with each other to learn and offer support throughout the unknown journey that awaits us. Did I mention there are two retreats? One to San Miguel de Allende, Mexico and the other, Tuscany, Italy.
When I got the email invitation from Amber to apply for the Alive Tribe the excitement hit me immediately. Let me set the scene for you:


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Totally Vegan and Bokeh Christmas Light Approved Chai Spice Sugar Cookies
(So good when dipped in coffee or Chai Tea!)
I originally found the base recipe on My Baking Addiction, but after making the first batch, I wanted to tweak it to fit my own palette.
2 3/4 cups all-purpose flour (I now do 1 3/4 all-purpose and 1 cup wheat or multi-grain flour)
1 teaspoon baking soda
1/2 teaspoon baking powder
1/2 teaspoon salt
1 3/4 cups white sugar (I now replace it with 1 cup turbinado or demerara sugars and 3/4 white sugar)
2 1/2 teaspoons ground cinnamon
1 teaspoon ground ginger
1 teaspoon ground cardamom
1/2 teaspoon ground allspice
1/4 teaspoon finely ground black pepper ( actually grind my own pepper for this)
1 cup unsalted butter, softened (I use the Earth Balance Shortening Stickshttp://www.earthbalancenatural.com/product/natural-shortening/, but here is the the link to vegan butter I made in the past just for reference:http://www.veganbaking.net/recipes/fats/vegan-butters/vegan-butter)
1 egg (I use an egg replacer like Bob's Red Mill)
1/2 teaspoon vanilla extract (I have gone to 1/4 tsp. vanilla and 1/4 tsp. almond extract)
I pretty much follow these same mixing instructions:
1. Preheat oven to 350 degrees. Line a baking sheet with parchment paper (I use the silicone sheet as shown in the image); set aside.
2. In a large bowl, sift together flour, baking soda, baking powder and salt. Set aside.
3. In a medium bowl combine sugar, cinnamon, ginger, cardamom, allspice and black pepper. Remove 1/4 cup of the sugar-spice mixture, set aside to reserve for rolling the cookies.
4. In the bowl of a stand mixer fitted with the paddle attachment or in a large bowl with an electric mixer, beat the butter and sugar-spice mixture until light and fluffy, about 3 minutes.
5. Beat in egg (or replacer) and vanilla/almond extract, combine until fully incorporated.
6. Slowly blend in dry ingredients mixing until just combined.
7. Using a small scoop (2 teaspoons) roll dough into balls and then into the reserved sugar-spice mixture. Place dough balls on prepared baking sheet about 1 1/2 inches apart.
7. Bake in preheated oven for 8 to 10 minutes.
8. Let stand on baking sheet two minutes before removing to cool on wire racks.


text:
Make me richer
Garden shredder
The weekend weather has us dreaming of summer. Everyone has their fingers crossed that we're in for another season of sun and barbeques. Time to get the garden into shape. How much for a Bosch Rapid Garden Shredder AXT 2200?
Best: €209.99 Hardware Ireland
Avoid: €294.95 Handy Hardware
Saving: €84.96
Putting your car through the NCT is a strangely unsettling experience – sort of like the feeling you get when you walk through the blue instead of the red channel at airport customs when you're arriving home from holidays with one too many bottles of cheap booze. You just feel like you're going to get caught out. At any rate, no-one wants to have to do the NCT twice because of something that could have been easily fixed beforehand. How much for a pre-NCT test in Waterford City?
Best: €35 Self Service Auto
Avoid: €99 Advance Pit Stop
Saving: €64
You've never bothered to check how much your home insurance might cost if you decided to ditch the provider you've had for the past decade. But you should. It could save you enough for a few nights out on the town. How much to insure a four-bedroom detached farmhouse built in 1930 in Bailieborough, Co Cavan, with no alarm? Buildings cover of €300,000, contents cover of €50,000 and six-years no claims bonus.
Best: €384.09 Aviva, via Chill Insurance
Avoid: €600.67 Axa Broker via Chill Insurance
Saving: €216.58
Nothing like pottering about the wilds of Wexford, but make sure you keep your motoring costs as low as possible. How much for fully comprehensive car insurance for a 60-year-old housewife living in Wexford and driving a 1-litre VW Polo valued at €6,000, with zero penalty points and three years no-claims bonus?
Best: €387.01 Aviva via Chill Insurance
Avoid: €861.04 RSA via Chill Insurance
Saving: €474.03
Who would have thought there'd be a scramble to buy property again, especially in the capital, just a few years after it all collapsed? You've finally seen the house you want and it's time to trade up. What's the monthly cost of servicing a three-year fixed-rate €300,000 mortgage borrowed over 20 years on a property valued at €450,000?
Best: €1,928.85 BoI at 4.69 per cent
Avoid: €1,978.21 ICS at 4.99 per cent
Saving: €592.32 over the first year.
Sunday Indo Business


text:
Twobanded Japanese weevil
Number 86 ; April 14, 2011 ; Jeffrey K. Barnes
Twobanded Japanese weevil
Order: Coleoptera
Family: Curculionidae
Genus and species: Pseudocneorhinus bifasciatus Roelofs
The twobanded Japanese weevil, native to the Orient, was first found in the United States in 1914 near Philadelphia. Adults are flightless. The species' slow spread across the eastern states is likely caused by movement of nursery stock. Adult twobanded Japanese weevils feed on leaves of a broad range of host plants, and when they are abundant they can cause major damage especially to landscape plantings. They are stout weevils about one fifth inch long and covered with brown and grey scales forming two crossbands on the elytra. This species overwinters as adults, larvae and eggs. Females begin feeding on foliage and laying eggs in the spring. They fold and glue leaves of the host plant to form egg pods in which they deposit 1–9 eggs. They are assumed to reproduce parthenogenetically, and males are not found in the North American population. Larvae feed on roots of the adults' host plants. While adults cause defoliation, larvae destroy the roots.


text:
by Google
Monday, July 19, 2004
Park: #2
Established: 1968
Acres: 684,302
Annual Budget: $5,911,000 (FY 2004)
Visitation: 347,907 (FY 2004)
Highlights: Deep valleys, jagged peaks, cascading waterfalls, over 700 glaciers
Location: North Cascades National Park
Hours: Open all year but access is limited during the winter season, more.
Phone: 360-856-5700
Fees: NW Forest Pass - $5 daily, $30 annual, more.
Website: www.nps.gov/noca
Top Pics: 7 Images
Established in 1968, North Cascades National Park Complex is a hidden jewel of sorts. Frequently overshadowed by more popular parks like Mount Rainier, North Cascades offers an intense and rugged beauty, catering primarily to those folks who wish to take the road less traveled. The park is generally mountainous with some peaks reaching over 8000 feet in height. Ross Lake and Diablo Lake fill the valleys with emerald green waters, the color a result of light-effects on water suspended silt.
In my travels, I more or less stumbled upon this national park beauty. While passing through on my way to Spokane, WA, I found myself mesmerized by its soaring, jagged peaks, deep valleys, cascading waterworks, and 700+ glaciers.
Jump in the van with me as I drive through this spectacular national park.
Description & Pics


text:
- About
- Head of School and Dean's Welcome
- Sydney Conservatorium of Music Strategic Plan 2016–2021
- People
- History of the Conservatorium
- Pacific Alliance of Music Schools
- International Exchange and Partnerships
- Industry Partnerships and Engagement
- Our Latest News
- eNewsletter subscriptions
- SCM Ticketing Information
- School Tours and Workshops
- Hire SCM Venues
- SCM Musician Referral Program
- Work, Health and Safety
- Sydney International Piano Competition
Music in the 21st century is all pervasive. Never in the history of our distinctive art form has there been more opportunity for composers, performers, educators and scholars in the pursuit of musical excellence. From the concert hall to the big screen, the orchestra pit to the iPhone or from the Xbox to the opera theatre, the demand for our art is greater than ever.
Sydney Conservatorium of Music is this nation's premier tertiary music institution, playing a pivotal role in the Australian musical landscape, increasingly so in the Asia Pacific. Ideally situated at the centre of Sydney's CBD and arts precinct, and minutes from the Sydney Opera House, the Sydney Conservatorium of Music provides a comprehensive musical education, imparting the necessary knowledge, skills, and aesthetic to thrive in this exciting new century of music. We celebrated our Centenary in 2015.
Our degree programs at both undergraduate and postgraduate levels underscore the four key areas of performance, composition, music education and musicology. Mentored by leaders in your chosen field, you may either specialise in your area of interest or explore combinations of areas. As a student of the University of Sydney, you'll engage with a community of scholars comprising the top 40 universities [1] in the world, including Harvard, Yale, Oxford and Cambridge.
Sydney Conservatorium of Music graduates enjoy successful careers as soloists or orchestral musicians, composers, academics and educators, critics, writers and arts administrators. The keys to our graduate successes are the highly dedicated faculty of teachers, performers and scholars and a diverse and highly talented student body – all of whom share a passion for music making.
Entry into the Sydney Conservatorium of Music is highly competitive. If you study here, you can expect to be challenged beyond your perceived boundary of technical ability and musical creativity. You can be assured, however, that the skills you develop and the experience gained in your time at the Sydney Conservatorium will be a touchstone of excellence and a capstone educational experience for the rest of your life.
We invite you to come and share in our dynamic musical world.
[1] QS World University Rankings® 2012/2013 www.topuniversities.com/university-rankings/world-university-rankings/2012


text:
Thông qua những giáo án unit 1 Personal experiences - Tiếng Anh 11 được một số giáo viên có kinh nghiệm chia sẻ góp phần giúp bạn nâng cao hiệu quả dạy và học. Ngoài ra những giáo án này còn giúp cho các thầy cô giáo thuận tiện và dễ dàng hơn trong việc cung cấp những kiến thức trọng tâm của bài cho học sinh, giúp các em thực hành nói về các kinh nghiệm, cách sử dụng các thì quá khứ để nói về các hoạt động cũng như những sự kiện diễn ra trong quá khứ.
32p 789_thuychi 28-03-2014 312 48 Download
Even with limited programming experience, you can easily learn to create apps for the Android platform with this complete guide to App Inventor for Android. App Inventor for Android is a visual language that relies on simple programming blocks that users can drag and drop to create apps. This handy book gives you a series of fully worked-out apps, complete with their programming blocks, which you can customize for your own use or use as a starting point for creating the next killer app. And it's all without writing a single line of code. Don't miss the book's special section...
385p titatu_123 09-03-2013 84 39 Download
Tuyển chọn những bài giảng được thiết kế sinh động, lôi cuốn dành cho các tiết học của bài Personal experiences - Tiếng Anh 11 mời các bạn cùng tham khảo. Thông qua những bài giảng này, quý thầy cô giáo có điều kiện học hỏi những kinh nghiệm soạn giáo án để có thể chuẩn bị tốt nhất cho tiết học.
29p thanhha_14 31-03-2014 123 35 Download
TinyXP Rev02 by eXPerience - Windows XP Professional Corp SP2 (Re-POST) Đây là bản Win XP đă được lược bỏ các components/Services không bao giờ đụng tới, chạy cực cool dành cho các Gamer thứ thiệt được thực hiện bởi ExPerience
4p daisuphu 28-07-2010 109 13 Download
Tham khảo tài liệu 'let's go 5 third edition unit new experiences', tài liệu phổ thông, tiếng anh phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả
16p thusau1981 22-09-2013 56 12 Download
A number of people have read all or part of the manuscript at various stages of its development. They are too numerous to be listed, but I want to thank them all for their help and criticism. Byron Wien, in particular, has gone beyond the call of duty in reading and commenting on, the manuscript at three different stages of development. Special thanks are due to Antonio Foglia, who generated the graphics that illustrate the real-time experiment. Larry Chiarello supplied the figures.
390p transang3 28-09-2012 20 7 Download
Ebook The usborne big book of experiments helps children can investigate the world around them and discover science in action. Specially chosen activities include making electricity, bending light and weather watching. Helpful descriptions, clearly written text and explanations show how and why the experiments work. Striking artwork and photographs illustrate all projects with clarity.
95p thieulam5782 04-10-2015 57 22 Download
Have you ever wondered whether the forensic science you've seen on TV is anything like the real thing? There's no better way to find out than to roll up your sleeves and do it yourself. This full-color book offers advice for setting up an inexpensive home lab, and includes more than 50 hands-on lab sessions that deal with forensic science experiments in biology, chemistry, and physics. You'll learn the practical skills and fundamental knowledge needed to pursue forensics as a lifelong hobby—or even a career....
450p ringphone 07-05-2013 31 6 Download
.Experience Sampling Method ..Experience Sampling Method Measuring the Quality of Everyday Life Joel M. Hektner North Dakota State University Jennifer A. Schmidt Northern Illinois University Mihaly Csikszentmihalyi Claremont Graduate University .Copyright © 2007 by Sage Publications, Inc. All rights reserved. No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the publisher.
369p camchuong_1 04-12-2012 27 4 Download
I would like to share you an experience I had learnt last semester when we learn Market leader – an English material. The professor asked us to present one company in a group of four students and our performance would be graded as a middle exam. We were all anxious because it was the 1st time we worked in group and presented in front of the crowd. Still, there were a lot of tasks that we did not know how to get it done. I was vice – monitor of the class so I was honored to be nominated as...
2p dothuymo0201 19-12-2012 37 4 Download
for papers for this book, in which we called for, among other things, "Visions and Goals for the Future" and "Techniques and Best-Practises". The way we see it, this book is as a collection of experiences of role-playing, trying to build a strong enough understanding of this medium, hobby, art, to facilitate this, maybe in the next Knutpunkt book. Maybe it is not yet time to press ahead as hard as we wanted to
142p mymi0809 21-01-2013 19 3 Download
Báo cáo khoa học: "Explaining German Case through Computational Experiments in Fluid Construction Grammar"
German case syncretism is often assumed to be the accidental by-product of historical development. This paper contradicts this claim and argues that the evolution of German case is driven by the need to optimize the cognitive effort and memory required for processing and interpretation. This hypothesis is supported by a novel kind of computational experiments that reconstruct and compare attested variations of the German definite article paradigm.
11p bunthai_1 06-05-2013 29 3 Download
We investigate the controversial issue about the upper bound of interjudge agreement in the use of a low-level grammatical representation. Pessimistic views suggest that several percent of words in running text are undecidable in terms of part-of-speech categories. Our experiments with 55kW data give reason for optimism: linguists with only 30 hours' training apply the EngCG-2 morphological tags with almost 100% interjudge agreement.
5p bunthai_1 06-05-2013 16 3 Download
Overview "Travel Demand Model Estimation and Validation: Experience from the USA ": Travel Demand Models, Model Calibration & Validation, Additional Information.
127p trinhhungvn 05-05-2015 21 4 Download
I recently conducted a Facebook ads experiment, and this ebook is a collection of tips that resulted from it. I wrote a blog post that provided background on why I conducted the experiment titled An Experiment: Facebook Ads Don't Have to Suck. I felt that post was the best possible way to introduce what would follow.
71p pierre1991 03-01-2016 17 5 Download
Nearly a decade has passed since the publication of the first edition. Many instructors have used the first edition to teach master's and Ph.D. students. Based on their feedback and our own teaching experience, it became clear that we needed to revise the book to make it more accessible to a larger audience, including upper-level undergraduates. To this end, we have expanded and reorganized the early chapters in the second edition. For example, our book now provides a self-contained presentation of regression analysis (Sections 1.4-1.
0p thienbinh1311 13-12-2012 32 2 Download
The choice of verb features is crucial for the learning of verb classes. This paper presents clustering experiments on 168 German verbs, which explore the relevance of features on three levels of verb description, purely syntactic frame types, prepositional phrase information and selectional preferences. In contrast to previous approaches concentrating on the sparse data problem, we present evidence for a linguistically defined limit on the usefulness of features which is driven by the idiosyncratic properties of the verbs and the specific attributes of the desired verb classification. ...
8p bunthai_1 06-05-2013 14 2 Download
We describe a set of experiments using automatically labelled data to train supervised classifiers for multi-class emotion detection in Twitter messages with no manual intervention. By cross-validating between models trained on different labellings for the same six basic emotion classes, and testing on manually labelled data, we conclude that the method is suitable for some emotions (happiness, sadness and anger) but less able to distinguish others; and that different labelling conventions are more suitable for some emotions than others. ...
10p bunthai_1 06-05-2013 11 2 Download
Experience idea "Using and managing role play in classroom" is to give the students an opportunity to work with others in determining how an individual or group might behave in response to a particular situation. Role playing is often used primarily to promote classroom discussion. The use of role playing as a cooperative learning model also includes class discussion as a vital step, but in this approach the entire class is involved in preparing and presenting role plays through group activity.
17p yenkhang32 13-04-2016 28 4 Download
Determinants of Productivity for Military Personnel - A Review of Findings on the Contribution of Experience, Training, and Aptitude to Military Performance
Reviews the primary literature and empirical findings related to three major factors that affect military personnel productivity: experience, training, and ability. The majority of studies concerning the relationship between productivity and experience, training, or aptitude find that each of these three factors contributes significantly to
0p xuancoem 01-02-2013 16 1 Download


text:
Without a federal match, the fiscal reality is grim whether or not Arizona restores the childless adult population to AHCCCS.
To read more on this item plus all the stories in the April 29 Yellow Sheet Report, go to www.yellowsheetreport.com (Yellow Sheet Subscription Required).
To subscribe to the Yellow Sheet Report, where you'll find the inside scoop on the Capitol, state government agencies and more, click here.


text:
Simplistic Enumerations for ActiveRecord
April 2nd, 2009 by michael
Invariably, in almost every application there happen to be lists of data items that are immutable, just for reference. It could be colors, the four seasons, continents, the states of your country, kinds or types of this and that. These items are almost like constants. As accessible as they are through the ordinary ActiveRecord API, it seems an utter waste to hit the database again and again, for data that won't change however often you request it.
Of course, the Rails community recognized early on that some data are more constant than others and over the years several plugins have been published that add cached and easily accessible enumerations to ActiveRecord. Some of these additions are quite complicated or befuddle ActiveRecord by not backing the enumeration values with real database objects. My experience has been that these attempted optimizations result in bizarre behavior when I did interesting things with ActiveRecord such as multiply nested named scopes plus custom SQL.
So, I thought a basic, no, simplistic, version of enumerations is called for. Here's how it looks:
class Color < ActiveRecord::Base enumerates do |e| e.value :name => 'red' e.value :name => 'green' e.value :name => 'blue' end end Color[:green] Color.find_by_name('red') Color.find_by_name!(:red) Color.all Color.count Color.reload
e.value :name => 'red'
ensures that a Color object with name 'red' exists, if it does not, one is created.
Although there is a
#reload method defined on enumeration models, i.e.
Color.reload, it is very unwise to use it. The point is that this method only affects a single server process and you most likely have many of them.
So, if you need to change enumeration values, the only way to do it is to treat it like an update to your application code.
Getting it
- github
- $ sudo gem install mschuerig-easy_enums
Let your Rails app know about it
In the appropriate place in
config/environment.rb add
config.gem "mschuerig-easy_enums", :lib => 'easy_enums'
2 Responses to "Simplistic Enumerations for ActiveRecord"
on 28 May 2009 at 11:401 Christoph Petschnig
For exact the same problem, I find ConstantRecord very helpful. It is very lightweight and can be easily exchanged with ActiveRecord in both directions: http://github.com/ChristophPetschnig/constantrecord
That's interesting. How well does it work in more complicated settings, say as a condition in a query with several joins?
I've written easy_enums primarily because I'd run into problems with another plugin that tried to avoid database tables for enumerations. Yours may work perfectly, I don't know, but I'm wary nonetheless.
Browsing around on Github, I just noticed enumerate_by. I'll have a closer look at it and possibly deprecate my own stuff in favor of it.


text:
Klokan On 30/07/2013
to ešte niekto chodí na fotolog? :)
Suliati On 29/03/2012
Hello my Dear
how are you and how is everything going with you over in your country? i am is suliatimabou by name i saw your profile please i will like you to contact me with this email address ([email protected]) so that i can sent you my picture (www.fotolog.com)
Debylak On 14/01/2012
:D dobre!


text: usm_crmda_mm131 mm131 crmda usm yes There is enough food; [n.d.] Public welfare Mississippi Freedom Democratic Party Mississippi Freedom Labor Union Delta Ministry of Mississippi Poverty--Mississippi Poor African Americans--Mississippi Race discrimination--Mississippi Public welfare--Mississippi Food stamps--Mississippi Nutrition--United States From the Miller (Michael J.) Civil Rights Collection; The brochure discusses the use of food stamps and the unequal distribution of commodities in Mississippi, lists the food categories from which everyone should eat to maintain physical health, and points out the federal government will be hiring Mississippians to give out the food commodities to the poor. Electronic version made available through a National Leadership Grant for Libraries from the Institute for Museum and Library Services. University of Southern Mississippi. Libraries Image; Text http://digilib.usm.edu/cdm/compoundobject/collection/manu/id/3644/rec/1 image/jpeg Digital reproduction of a 4-page document. Box 3 , Folder 4, M336 Zwerling (Matthew) Freedom Summer Collection, McCain Library and Archives, University of Southern Mississippi Forms part of the Civil Rights in Mississippi Digital Archive. Forms part of USM - Historical Manuscripts. Forms part of University of Southern Mississippi Digital Collections. Forms part of the Mississippi Digital Library. Forms part of the Michael J. Miller Civil Rights Collection in the Civil Rights in Mississippi Digital Archive. 1964 United States, Mississippi, 32.354668, -89.398528 Copyright protected. Use of materials from this collection beyond the exceptions provided for in the Fair Use and Educational Use clauses of the U.S. Copyright Law may violate federal law. Permission to publish or reproduce is required.


text:
MBTA Trip Planner
There are many tools on the web to help you determine the fastest, safest, and least expensive way to get where you are going. Here are a few of our favorites:
MBTA Rider Tools
To help you make the most of the T, MBTA.com offers powerful tools that are all about you. Use the Trip Planner to plan a trip using T transit services. Service Nearby will show you a map of all the stops and routes close to any location. Service Updates gives you up to the minute information about the status of all MBTA routes, elevators and escalators.
Park and Ride Lot Map
This MA DOT map provides information on the Park & Ride Lots throughout the Commonwealth that are available for people wishing to carpool or vanpool to work. Commuter bus service is also available from many of the park-and-ride lots. Please click on the lot locations for additional information.
Map A Bike Route
Ride the City, is a website that helps you find safer bike routes in cities. Like other mapping applications, Ride the City finds the shortest distance between two points, with a difference. First, Ride the City avoids roads that aren't meant for biking, like highways and busy arterial streets. Second, Ride the City tries to steer cyclists toward routes that maximize the use of bike lanes, bike paths, greenways, and other bike-friendly streets.
Map A Walking Route
Google Maps allows you get directions and choose walking as your mode.


text:
This editorial was developed for AAN.com, which is publishing expert opinions on a variety of hot topics in neurology.
Josep Dalmau, MD, PhD
University of Pennsylvania
Author Disclosure Statement
Limbic encephalitis was initially reported as a paraneoplastic manifestation of cancer. For many years it was thought that the disorder was extremely rare, invariably associated with cancer, and unresponsive to treatment. In the mid 1980s and 90s, the discovery of antineuronal antibodies (Hu, CV2/CRMP5, Ma2, amphiphysin, among others) reinforced some of these concepts by facilitating the identification of a subgroup of encephalitis in which the accompanying T-cell mechanisms are difficult to treat.
However, with the development of clinical criteria that includes testing for antineuronal antibodies, brain MRI, and CT or FDG-PET to uncover associated tumors, it is becoming clear that many patients with similar syndromes do not fit the above concepts.1 The study of these patients is changing the previously accepted views on limbic encephalitis with implications beyond the limbic syndromes, paraneoplastic or not.2
The detection of voltage-gated potassium channel (VGKC) antibodies in some patients with limbic encephalitis was an initial step toward the identification of a new category of this condition. Antibodies in this syndrome are directed against a cell surface antigen (VGKC), whereas in previously characterized syndromes the antigens were intracellular. In 80 percent of patients with VGKC antibodies the disorder is not paraneoplastic and responses to immunotherapy are frequent. Similar antibodies may also occur in patients with a syndrome consisting of more diffuse encephalitis associated with hallucinations, sleep and autonomic dysfunction, and peripheral nerve hyperexcitability (Morvan's syndrome).
Yet, many patients with limbic or a more diffuse encephalitis do not have any of the antibodies indicated above. In these cases, the CSF findings and response to empiric immunotherapies (e.g, IVIg, plasma exchange) suggest an immune pathogenesis.
The term limbic encephalitis refers to an inflammatory process involving the hippocampi, amygdala and less frequently frontobasal and insular regions. Symptoms include changes in behavior and mood, such as irritability and depression, sleep disturbances, seizures, and short-term memory deficits. The disorder can be difficult to recognize in patients with low levels of consciousness due to frequent seizures, hypothalamic involvement, or progression of the encephalitis to other brain regions. Abnormal EEG and MRI findings predominate in the medial temporal lobes, although neuropathological studies usually reveal inflammatory infiltrates beyond the limbic system. CSF analysis is often abnormal, with lymphocytic pleocytosis, increased proteins, or oligoclonal bands.1
The strategy to identify antibodies to cell surface antigens relies on:
Once a specific syndrome and pattern or immunolabeling are identified, further studies are undertaken to characterize the antigen(s). The most interesting example of a recently detected antigen of this nature are the NMDA receptors.5
Figure: Immunohistochemical demonstration of antibodies against a cell surface antigen (NMDA receptor). A: Hippocampus of rat showing in green the reactivity of a patient's CSF with antibodies against NMDA receptors; note the extensive reactivity with the neuropil. Compare this reactivity with that of an antibody against an intraneuronal antigen (anti-Hu: red cells). B: Culture of live, non-permeabilized, hippocampal neurons immunolabeled with CSF containing antibodies against NMDA receptors; note the intense antibody-binding to the surface of neuronal processes (the nucleus of the neuron is shown in blue).
This disorder was initially identified in young women with mature or immature ovarian teratoma who developed prominent psychiatric symptoms or memory deficits, usually preceded by prodromal fever, headache or a viral-like illness. After the initial psychiatric presentation, most patients develop seizures, decrease in the level of consciousness, orofacial or limbic dyskinesias, autonomic instability and hypoventilation. Prolonged intensive care support is frequently required.6 Removal of the teratoma and immunotherapy (e.g., corticosteroids, IVIg, plasma exchange, rituximab, cyclophosphamide) is often associated with improvement or total recovery. Most recently studies indicate:
The antibodies associated with this syndrome are directed to cell surface epitopes present in assembled NR1 and NR2 subunits (NR1/NR2 heteromers) of the NMDA receptor. Thus, the technique to detect these antibodies is immunocytochemistry on cells transfected with NR1 and NR2 subunits. These antibodies should not be confused with other antibodies against NR2 subunits of the NMDA receptors that in general have poor syndrome specificity. The latter antibodies are usually identified by immunoblot techniques.
In addition to the encephalitis associated with antibodies to NMDA receptors, there are additional encephalitides that occur in association with antibodies to other cell surface antigens and clinical syndromes. For most, the cell surface antigens are pending characterization. The importance of studying these disorders rests on the following facts:
Disclosure: Dr. Dalmau has received personal compensation as a speaker for Athena Diagnostics.


text:
Dear all, It has been a very efficient F2F meeting today, and we have wrapped up, and are about to leave the building, which is closing at 4 o'clock local time. Thus, we have cancelled the call-in-wrappup we talked about last teleconf. Best, KjetilReceived on Monday, 23 April 2007 13:40:33 UTC
This archive was generated by hypermail 2.3.1 : Tuesday, 6 January 2015 20:28:53 UTC


text:
Hosts USA hit Kenya in Las Vegas Sevens quarters
Monday March 7 2016
Kenya's much-celebrated 22-0 victory over New Zealand on Day Two of the Las Vegas Sevens on Sunday failed to inspire the team as they succumbed to hosts USA 14-26 to drop to the Plate semi-finals.
Danny Barrett put Mike Friday's USA ahead when he picked a great line after Garrett Bender's spade work to ground under the posts for a 7-0 lead in the thrilling Cup quarter-final duel.
The Americans were dominant at the ruck with good possession for an attack that the deadly and speedy Perry Baker finished off to stretch their lead to 14-0.
However, Kenya staged a strong comeback with Collins Injera and Billy Odhiambo crossing for tries to silence the partisan crowd.
Biko Adema nailed both conversions to level 14-14 at the break.
It was Injera's fourth try of the weekend that took his tally 218 tries, three short of England legend Ben Gollings, who is second in the all-time list.
The hosts proved clinical on return when Martin Iosefo cashed in on Kenya's sloppy defence to score and extend the US' lead to 21-14.
The Kenyans were punished further when Zack Test sliced through another gap after great work from Danny Barrett at the breakdown to cross the line for USA victory.
The Americans' win brought down the high-flying Kenyans who had beaten Wellington and Sydney Sevens champions New Zealand for the first time in three years to emphatically top Pool "A".
The defeat ended Kenya's hope of making their second Cup semi-finals this season since Cape Town Sevens where they finished fourth.
New Zealand and Argentina were to face-off in the other Plate semi.
All Blacks lost to Cape Town Sevens champions South Africa 7-14 while Argentina fell to 12-26 to Australia. USA were to play Fiji in the semi-finals.
Fiji booked a place in the last four with a routine 43-7 win against Japan. Three-time USA Sevens champions South Africa come up against Australia in the other semi.
Oscar Ayodi and Oscar Ouma scored but Adema missed one conversion in addition to a penalty as Kenya led All Blacks 12-0 at the break. Adema then converted substitute William Ambaka's try before slotting over a penalty for the victory.
The last time the teams had met was at Wellington Sevens Cup quarters where All Blacks triumphed 36-0.
It was Kenya Sevens first win against the All Blacks Sevens since the 2013 Wellington Sevens when Mike Friday was Kenya Sevens coach. The team also topped their pool for the first time since cape Town Sevens in December.
Kenya were due to play Japan in the Plate semi-final late Sunday night with a potential final showdown with New Zealand for the silverware and 13 points.


text: I have a nine button optical usb mouse (GE) and I would like to get the second scroll-wheel either working correctly or disabled. At first I thought the drivers wouldn't support the extra scroll-wheel and just ignore it or treat them both as one. uhidev0 at uhub0 port 2 configuration 1 interface 0 uhidev0: A4Tech USB Optical Mouse, rev 2.00/1.00, addr 2, iclass 3/1 ums0 at uhidev0: 7 buttons and Z dir. wsmouse0 at ums0 mux 0 This seems to indicate that only seven buttons are supported but, I have strange behavior in X. Identifier "Mouse1" Driver "mouse" Option "Protocol" "wsmouse" Option "Device" "/dev/wsmouse" Option "Buttons" "7" Option "ZAxisMapping" "4 5" This seemed to work at first but, it has annoying side-affects. Using xev I can see that the two side buttons don't work at all - unless I've just used the second scroll-wheel. Also, the second scroll-wheel send the same signal (4 5) unless I've just used the first - then it send a 7 sig. This means that when scrolling down a page, I move to the right about have the time and can't go back. (I also can't go anywhere sideways while still). I don't mind the side buttons, I just want to stop this annoying seventh button. -- Nathaniel A. A. Hill <firstname.lastname@example.com>


text:
Advances in health care are not all in operating rooms or laboratories. Technological advances have rapidly changed the face of health care information and how it is used and disseminated. This new field informatics has expanded the nurse's role and opened the door to a new career path.
But what is it?
Informatics is the science and art of turning data into information, explains Toni Hebda, professor, Master of Science in Nursing Degree Program at Chamberlain College of Nursing. Nursing informatics focuses on methods to support the ways that nurses work, nursing education, and applications that promote consumer health, adds Hebda.
"Typically, informatics entails the use of computers and statistical techniques in the management of information," she says. "The intent is to make information more readily available when it is needed, where it is needed, and to persons that need it."
In addition, gathered data can be used to identify patterns and trends, leading to better informed, more timely decisions in patient treatment and care.
"Informatics is also concerned with safeguarding private information, as well as legal and ethical issues related to information use," Hebda says. "Additionally, informatics examines the use of technology, which has become a pervasive factor in today's world. The term has been applied to various disciplines so that within health care alone one will hear the terms health informatics, medical informatics, consumer health informatics, public health informatics, and nursing informatics, among others."
Growth predicted
With the approval of the Health Information Technology for Economic and Clinical Health Act (HITECH) in 2009 and funding for electronic health records (EHR) technology, the Office of the National Coordinator of Health IT anticipates 50,000 new health information technology jobs will be created within the next five years, says Hebda.
To help meet this demand, Chamberlain recently added a Master of Science in Nursing (MSN) Informatics specialty track to help prepare nurses for the field. The first class began last month.
The program prepares students in both the patient and technological sides of health care, teaching them to interpret, analyze and utilize EHR technology, as well as other means to promote greater efficiency and effectiveness in health care practices. Chamberlain's MSN Informatics specialty track has been designed to provide students with practical experience and enable them to sit for the American Nurses Center Credentialing Examination, says Hebda.
"It is offered through online courses to support busy nurse professionals interested in pursuing this degree while juggling their responsibilities at work and home, " she adds.
The program can be completed in as few as two years. Coursework includes the practice of nursing informatics, management of data and information, health care information workflow, and project management. Students must first successfully complete the core requirements of Chamberlain's Master of Science in Nursing degree program before they can move into the informatics specialty track.
At work
Carolyn Messerschmidt was an informaticist before the career even had a title.
"I started in the field right at the time it was being recognized as a specialty in the field of nursing," says the Information Systems Clinical Coordinator at Elmhurst Memorial Healthcare. "At that time, many people did not understand what the field of nursing informatics was all about. There were many different definitions to describe the field."
At EMH for 10 years, Messerschmidt says within the past two decades she has seen organizations go from a "paper and pencil world" to becoming completely electronic. "With the rapid advances in technology as it relates to patient care, patient safety and nursing practice, in general the (informatics) field has grown tremendously."
Messerschmidt says her days are anything but typical. Each day she takes a combination of computer science, information science, and nursing science and incorporates these into her daily practice to help support the nursing staff, deliver medical care, and manage data.
"We also support the various computer applications within our hospital clinical information system on a daily basis," she adds.
Messerschmidt enjoys the many challenges and opportunities the speciality presents, especially since health care organizations such as EMH are preparing for the Medicare and Medicaid Electronic Health Record Incentive Programs (also known as Meaningful Use). These programs provide temporary incentive payments to eligible hospitals and physicians that adopt certified EHR technology and are "meaningful users" of those systems.
As Hebda also points out, informatics is on the forefront of this movement to electronic records.
"There is no shortage of work to be done," adds Messerschmidt. "Nursing informatics plays a large role in being able to assist the organization in meeting the goals for Meaningful Use."
Messerschmidt believes this is a good career fit for her because of her communication and customer service skills, as well as a solid clinical background. Having that solid background, she says, is important for any nurse considering entering the informatics field.
"I would stress that they get some solid clinical experience under their belts," she says. "It is important to understand the nursing process and workflow because the informatics role includes the development of applications, tools and processes that assist nurses in managing data in taking care of patients."
Right for whom?
Often nurses are attracted to informatics because they have a strong interest in computers, technology, information systems, and ways to better support patient care, says Hebda.
She agrees with Messerschmidt about the importance of a strong background along with technical aptitude.
"While technical expertise and computer knowledge are helpful, a strong clinical background is critical as informatics nurses are called upon to translate the needs of working nurses into requirements that programmers and information systems professionals can understand and turn into workable solutions," she says.
"Therefore, good communication or people skills are also critical."
The job prognosis for this field is excellent as opportunities continue to expand.
"Informatics nurses can be found working in government, hospitals and ambulatory care settings, working for vendors, teaching and supporting technology, and applying informatics in nursing schools," says Hebda. "They help to design, implement, and evaluate applications. Their tasks include assessing the needs of the population, helping to design or acquire solutions, testing usability, evaluating applications, as well as helping to educate and shape policy and legislation related to information use."
For more information on Chamberlain's informatics specialty track, visit chamberlain.edu/msn.


text:
Posted 19/08/16
By Koray Hussein
It's Friday and we've got yet another classy #maybeLDNer feature for you!
As always, I don't want to bang on too much at the start of these features as you're not here for me. You're here for the photography.
Before we get started we once again must stress that only images uploaded in the last week (since last Friday) will be considered for the competition, regardless of when the hashtag was added. It just makes it easier to judge considering we now have over 136,200 images using #maybeLDNer on Instagram.
1. londonviewpoints
2. @lmbk
3. @boss_bean
4. @storyoflondon
5. @james_english_photography
Those are our five picks, we hope you liked them… Ah, who are we kidding? Of course you did. These guys are great. If you haven't already; drop by our Facebook & Twitter and give us a like & a follow. It helps the site out tremendously and we really appreciate it.
You can also check out our previous winners by clicking on "Previous Article" down below.


text:
4+ Years Of Experience
Consultant, Rheumatology S. L. Raheja Hospital, Mahim
Fellowship in Rheumatology ,
Master of Medicine.
Gained expertise in treating common diseases like rheumatoid arthritis, fibromyalgia, ankylosing spondilytis. At the same time I have also good experience in managing challenging cases like SLE,vasculitis, sjogrens syndrome, inflammatory myositis. Have also seen many uncommon diseases like relapsing polychondritis, pagets disease, morphea. During this period I have gained confidence in the use of routine DMARDS as well as newer biologicals. I have good experience of intra-articular injections.


text:
See the First Pages of Tony Hale's Children's Book
When "Veep" star Tony Hale first arrived in Los Angeles twenty years ago, the Emmy-Award winning actor had one goal in mind: To land a sitcom. "I put so much expectation on that big thing in my life of getting that sitcom that nothing could match that," he tells Speakeasy. That moment came when he got "Arrested Development," where he played neurotic Bluth son Buster for three seasons before Fox cancelled it in 2006. But during that experience, he kept thinking about what was coming next instead of living in the moment. "I found myself so focused on that next adventure, that I was missing the adventure I was on."
Hale has turned that concept into his first children's book, titled "Archibald's Next Big Thing." It follows a bald chicken who embarks on fantastic adventures, yet is always looking for what's next instead of living in the moment.


text:
The Glenrosa Elementary Parents Advisory Council is crossing their fingers for good weather tonight (Friday) as they host the school's second annual Christmas Market, from 4 to 9 p.m.
According to Glenrosa Elementary PAC president Bobbi Briden, last year's event didn't get any help from Mother Nature. "We actually had a bit of a snow storm come in on the day of, so it was a little slower."
If the numbers are any indication, Briden has little to worry about this year. The 2010 event featured 36 vendors; nearly 50 have already signed up for this year's market.
The Christmas Market will feature a variety of local artisans, crafters and bakers. A couple volunteer singers will belt out Christmas carols to get guests in the holiday spirit.


text:
New Neighbors group plans Friday meeting
The New Neighbors general meeting will be held Friday at the Lubbock Women's Club, 2020 Broadway.
Cost is $13 and officer Mike Shipman of the Lubbock Police Department will share ideas on safety.
Reservations need to be made by today. For more information, call Marry Valentini at 799-4450.
Health Department sets drive-thru flu clinic
The City of Lubbock Health Department will have an adult drive-thru flu clinic for the seasonal influenza vaccine for ages 19 and older, from 11 a.m. to 2 p.m. today at the Health Department parking lot, 1902 Texas Ave.
The cost is $20 per person and Medicare will be accepted. No walk-ups and no children will be vaccinated.
You must take 19th Street to Texas Avenue and head south on Texas Avenue and 23rd Street. Turn west onto 23rd Street, take 23rd Street to Avenue J.
Vino Festivo to be held Thursday at Cap*Rock
The sixth annual Vino Festivo will be held from 6:30 to 9:30 p.m. Thursday at the Cap*Rock Winery, 408 E. Woodrow Road.
Tickets are $40 per person and include wine, heavy hors d'oeuvres and entertainment. Table sponsorships are available.
For tickets or more information, call 763-6131 or visitf www.bbbslubbock.org.
Stella's holding clothing drive for needy children
Help keep Lubbock kids warm from 5:30 to 7:30 p.m. Thursday at Stella's Restaurant, 4646 50th St.
Bring gently used fall and winter clothing. Door prizes will be given away.
Clothes will be donated to The Children's Home of Lubbock, and J. Hilburn's new fall line will be showcased.
For more information, call 781-8240, 544-7389.
Floydada chamber sets annual Punkin Day
The Floydada Chamber of Commerce and Agriculture is hosting the 23rd annual Punkin Day Celebration Saturday beginning at 7 a.m. with a fun run.
There will be an arts and crafts show, food vendors, pumpkin baked goods contest, a classic car show, costume contests and more.
For more information, call 983-3434
Friends of Library in need of more volunteers
Friends of the Lubbock Public Library need volunteers at the Mahon Library basement for preparation for the annual book sale. Volunteer hours are Tuesdays from 2-8:30 p.m., Wednesdays and Thursdays from 9 a.m. to noon and Saturdays from 9 a.m. to 3 p.m.
Volunteers will sort and shelve books. Just show up, no training needed.
For more information, call 866-9003.
The Bridge plans to host Harvest Shindig Oct. 15
The Bridge of Lubbock is hosting a Harvest Shindig from 6-10 p.m. Oct. 15 at the American Wind and Power Museum, 1701 Canyon Lake Drive.
There will be fun and games, a silent auction, a barn dance, live music, a pie eating contest, potato sack races and more.
For more information, call 687-0772.


text:
"A lot of celebrities don't know enough about their fans," Jim Mueller, CEO of Shoutz, told Mashable. "Shoutz provides real-time analytics that adds value for advertisers and makes it easier to manage campaigns, build brand strategies and target effectiveness."
한줄요약) Shoutz 는 무료의 소셜 비디오 네트워크. (말 참 어렵게 만들었네요)


text:
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text: On Sat, Apr 03, 2010 at 12:07:00AM +0200, Janos Haar wrote:> Hello,> > ----- Original Message ----- From: "Américo Wang"> <email@example.com>> To: "Janos Haar" <email@example.com>> Cc: <email@example.com>; "KAMEZAWA Hiroyuki"> <email@example.com>; <email@example.com>;> <firstname.lastname@example.com>; "Jens Axboe" <email@example.com>> Sent: Thursday, April 01, 2010 12:37 PM> Subject: Re: Somebody take a look please! (some kind of kernel bug?)> > > >On Thu, Apr 1, 2010 at 6:01 PM, Janos Haar> ><email@example.com> wrote:> >>Hello,> >>> >> >Hi,> >This is a totally different bug from the previous one reported by you. :)> > Today i have got this again, exactly the same. (if somebody wants> the log, just ask)> There is a cut:Small hint - please put the subsytemthe bug occurred in in thesubject line. I missed this in the firehose of lkml traffic becausethere wasnothing to indicate to me it was in XFS. Soemthing like:"Kernel crash in xfs_iflush_cluster"Won't get missed quite so easily....This may be a fixed problem - what kernel are you running?Cheers,Dave.-- Dave email@example.com unsubscribe from this list: send the line "unsubscribe linux-kernel" inthe body of a message to firstname.lastname@example.com majordomo info at http://vger.kernel.org/majordomo-info.htmlPlease read the FAQ at http://www.tux.org/lkml/


text:
The Tuck Rule game: Patriots 16, Raiders 13
Matthew J. Lee/Globe Staff
- Photos Patriots' 10 best playoff games | Interactive You rank Patriots' best playoff games
- Bostonglobe.com Game story | Bob Ryan column | Dan Shaughnessy column
Coleman explained his call after the game:
Obviously, what I saw on the field, I thought the ball came out before his arm was going forward. Then, when I got to the replay monitor and looked at it, it was obvious his arm was coming forward. He touched the ball. And they just hooked it out of his hand. His arm was coming forward, which makes it an incomplete pass.


text: Hi, I wanted to know the reason for the limitation for Maximum number of VGs, which is 100 currently. If it was based on bits in minor number, I was under the impression that it should have been 255 (where /dev/lvm occupies minor number 0 for the LVM Character device interface). Can someone clarify? Thanks, - Kishore


text:
Product Details
Waist Width
Camber: Shaped like upside-down U. Great for speed and stability.
80-89: Good float in powder; typically still carve pretty well
Style: A1303021
The Line Celebrity Skis are light, fun, and great carving skis. The Aspen core is super lightweight so you won't have to struggle to control them. The flex is designed to make turns smooth and stable, and the sidecut encourages turning with very little effort. The waist width is 85, so you can easily take your skis through the fresh snow in the trees. On the Line Celebrity, you can forget about the mechanics and focus on having fun.
- Design: Frontside/ All-Mountain
- Camber: Traditional
- Ski Dimensions: 115-85-112
- Turn Radius: 13.7m average
- Bindings: not included
- 4D Fibercap is fiberglass reinforced for lightweight durability
- Aspen Macro Block for an ultra lightweight feel
- Fatty Base Edge is 30% thicker for durability
- Directional flex for easy yet powerful turns
- 5 Cut blends different sidecut radii for seamless turns
Questions and Answers
ASK A QUESTION Got questions about this product? Ask them here. Got questions about anything else? Please see our FAQ.
"I wonder this Line Celebrity skis 157CM is 2014 ? This skis come with Binding ? if not please recommend what type of binding much better $ 170-200,( I wish toe is wider than waist of the skis ) Thank you . Shigeo Horie "
1 Answers | Answer Question
Question by Horie Sun Lodge on 1/13/2014 - 2:45 am
"This ski is a 2013/2014 year ski. This pair of skis does not come with the bindings. The binding that would fit this ski is: Atomic FFG 12 90 Ski Bindings "
Answer by Katie (Peter Glenn Staff) on 1/13/2014 - 11:54 am
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text:
I thought it was strange seeing that froakie wasn't a tadpole. But it turns out that there is a group of toads which give birth to smaller toadlets as their young
Do you think Froakie is based on them?
And there is this toad in which eggs are laid on the back of the parent and they hatch into toadlets.
Pretty weird huh? Maybe Gamefreak was interested in it too!


text:
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Latest ArticlesInformation About How At Decide Upon If An Absolute Excessive Fat Loss Application Will Work.
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text:
Product Description for NT3 Protein
NT3 Protein.
Presentation: Purified
Presentation: Purified
Properties for NT3 Protein
|Product Category
|Proteins & Growth Factors
|2 µg
|Molecular weight
|29.3 kDa
|Species (Protein)
|Shipping to
|Not USA/Canada
|PDF datasheet
|View Datasheet
|Novus Biologicals Inc.
Datasheet Extract
|Neurotrophin-3 (NT-3), also known as nerve growth factor-2 (NGF2) or hippocampus-derived neurotrophic factor (HDNF), is a 257 amino acid precursor protein with a secretory signal sequence of 16 amino acids, a pro-peptide of 122 amino acids and a mature protein of 119 amino acids. NT-3 is found in neurons of the central nervous system and is secreted by many human gliomas. NT-3 is also expressed in muscles and its expression is downregulated in denervated muscles. NT-3 selectively supports the survival of certain neuronal cell populations, for example, cultured embryonic rat spinal motor neurons, enhances axon sprouting following adult spinal cord lesions and is involved in the regulation of developing neuromuscular synapses. NT-3 is a useful growth factor, differentiation factor and survival factor for cultured stem cells e.g. neural stem cells, cardiomyocytes and embryonic stem cells as well as various types of differentiated neural cells such as oligodendrocytes. NT-3 acts as a mitogen for cells of the neural crest in serum-free media. The biological activities of NT-3 are mediated by receptors belonging to the Trk family of receptors with intrinsic tyrosine-specific protein kinase activity. NT-3 binds to TrkA, TrkB and TrkC, the first two of which are the high-affinity receptors for NGF and BDNF, respectively. NT-3 also binds to the low affinity nerve growth factor receptor (LAN R). This is a HCX protein. HCX Expression System Details HCX proteins mimic the proteins in the human body because they are expressed from human, rather than animal, insect or bacterial cells. This process gives them human post-translational modifications. Recombinant DNA techniques allow a human protein with the correct amino acid sequence to be expressed in a non-human cell line. However, non-human cells lack the appropriate cellular machinery, such as specific glycosyltransferases, necessary to produce the correct human post-translational modifications of a protein. An extreme example is seen in E. coli cells, which produce recombinant proteins with no glycosylation, as the above figure illustrates. Rodent and yeast cells are able to glycosylate proteins, but they are still different from glycosylation in human cells. Expression System Resultant Proteins Human (e.g. K562, HEK293) Correct amino acid sequence Human post-translational modifications Rodent (e.g. CHO, NSO) Correct amino acid sequence Some natural glycosylation - not human-like Yeast (e.g. Pichia) Correct amino acid sequence Some natural glycosylation - not human-like E.Coli Correct amino acid sequence No PTMs Although there have been significant attempts to make non-human cell derived cytokines more human-like, there is a growing awareness that in many instances, particularly in therapeutics, cytokines should mimic those found in the body as closely as possible.
|Lyoph mg/ml
|General Readings
|Chao MV, Rajagopal R, and Lee FS (2006) Clin. Sci (Lond) 110(2): 167-173.
|Store at -80C. Avoid freeze-thaw cycles.


text:
Victoria's Secret- home of overpriced lingerie and hypersexy models- has recently released a series of "sexy" sports bras, banking on the idea that women value haw perky their breasts look while working out over actual functionality and support. "We wanted to solve the uniboob problem, where your sports bra makes you look straight across — no one likes that," said a VS executive.
The executive also went on to say that women are aware of being "on display" at the gym, so looking good while exercising is important to them.
And all this time, I thought that women went to the gym to get/stay fit and healthy! Silly me, why else would we go to the gym if not to show off our bodies which apparently exist for others' viewing pleasure??
VS expected sales to boom- but they have sold far fewer than expected, while the bras have not been put on sale yet, they are expected to if sale do not go up.