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Nanocolloidal carriers of isotretinoin antimicrobial activity against propionibacterium acnes and dermatokinetic modeling 2013
Nanocolloidal Carriers of Isotretinoin: Antimicrobial Activity against
Propionibacterium acnes and Dermatokinetic Modeling
Kaisar Raza,† Bhupinder Singh,†,‡ Saloni Singla,§ Sheetu Wadhwa,‡ Babita Garg,‡ Sanjay Chhibber,§
and Om Prakash Katare*,‡
UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles and Nanocomposites, Panjab University, Chandigarh,
India 160014
Division of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India 160014
Department of Microbiology, Panjab University, Chandigarh, India 160014
ABSTRACT: Acne, a common skin disease in teenagers, is caused by
Propionibacterium acnes (P. acnes). Isotretinoin (ITR) is though reported
to have immense antiacne potential, yet there are hardly any reports
vouching its antimicrobial activity. The present study, therefore, was
undertaken to study the antimicrobial activity of ITR and evaluate the
effect of its encasement in nanocarriers on its minimum inhibitory
concentration (MIC). The nanocarriers were also evaluated for the skin
transport characteristics. MICs of pure drug and entrapped drug in
nanolipid carriers (ITR-NLCs) and in solid lipid nanoparticles (ITRSLNs) were determined by broth dilution method against clindamycin
phosphate as the reference antibiotic. It was observed that ITR
possessed marked antimicrobial activity against anaerobic pathogen, P.
acnes. Nanocarriers loaded with ITR, that is, SLNs and NLCs, enhanced
the antimicrobial activity even at lower concentrations vis-à-vis the drug alone and improved drug transport potential vis-à-vis the
commercial gel. The unique findings could be the result of effective adhesion of ITR-loaded nanocarriers to the bacterial
membranes and release of drug directly to the target. Besides establishing ITR as an antimicrobial agent against acne-causing
bacteria, the current work ratifies immense potential of nanocolloidal carriers like SLNs and NLCs to treat acne in a more
efficient manner.
KEYWORDS: minimum inhibitory concentration (MIC), solid lipid nanoparticles (SLNs), nanolipid carriers (NLCs),
Propionibacterium acnes, anaerobic pathogen, acne vulgaris, comedolytic
Though acne is seldom associated with mortality, it
substantially affects the psychological and social status of the
affected population.6,7 Other concerns associated with acne are
the long tenure of treatment along with economic issues.8
Topical retinoids alone, or in combination with antibiotics, are
widely prescribed for the treatment of mild to moderate
acne.9,10 For severe acne, however, oral isotretinoin (ITR) is
frequently prescribed.11 Use of antibiotics alone for the
treatment of acne has yielded promising results.12−14 Nevertheless, issues of microbial resistance against antibiotics are of
great concern.15,16 It is also advised that clinicians should limit
the prescription of antibiotics, wherever and whenever
possible.15 Hence, there are adequate reasons to search for
alternative therapy or to improve the efficacy of the present
treatment approaches.
Acne vulgaris, commonly known as acne, affects around 85% of
teenagers, reaching its acme during adulthood.1,2 According to
WHO, acne is an inflammatory disease of the pilosebaceous
units in the skin of the face, neck, chest, and upper back.
Typically, it first appears during early puberty when androgenic
stimulation triggers excessive production of sebum and
abnormal follicular keratinization, colonization by a Grampositive bacterium (i.e., Propionibacterium acnes), and local
inflammation. P. acnes is one of the principal factors of acne
pathogenesis. P. acnes produces inflammation through the
production of extracellular products such as lipases, proteases,
hyaluronidases, and chemotactic factors.1 It is the predominant
microorganism of the infected pilosebaceous glands of acne
skin, as nearly as 107 viable organisms are reported to be
isolated from a single sebaceous unit.3,4 P. acnes typically grows
in the infrainfundibulum of the pilosebaceous units and digests
the oily substance produced by the sebaceous glands.3 Apart
from acne, P. acnes overgrowth is also reported to be associated
with diseases like toxic shock syndrome and endocarditis.2,5
© 2013 American Chemical Society
December 21, 2012
March 11, 2013
April 1, 2013
April 1, 2013
dx.doi.org/10.1021/mp300722f | Mol. Pharmaceutics 2013, 10, 1958−1963
Molecular Pharmaceutics
dispersed in a portion of water along with Tween 80 (7.0 g)
and SMBS (0.5 g). Compritol (1.2 g) and IPM (0.2 g) were
melted at 70 °C. The lipid phase, aqueous phase, and drug
solution were mixed isothermally to obtain a clear microemulsion. The remaining portion of water (about 80 mL) was
cooled at 4 °C. The hot microemulsion formed was poured
into cold water previously maintained at 4 °C, and the
dispersion formed (100 mL) was stirred continuously for 20
min at 3000 rpm.23
2.3. Preparation of Bacteria. P. acnes (MTCC 1951)
(Microbial Type Culture Collection, IMTECH, Chandigarh,
India) was cultured on brain heart infusion media under
anaerobic conditions using Anaerogas Pack at 37 °C. Single
colonies were inoculated and incubated at 37 °C until reaching
around OD600 = 0.3 (logarithmic growth phase) under
anaerobic conditions. The bacteria were harvested by
centrifugation at 5000g for 10 min, washed with PBS, and
suspended in an appropriate amount of PBS.2
2.4. Antimicrobial Activity of ITR and Its Nanocarriers
against P. acnes. P. acnes was incubated in BHI broth with 1%
glucose for 48 h under anaerobic conditions and adjusted to
yield approximately 1 × 108 CFU/mL. 2-fold serial dilutions
were made in the broth over a range to give concentrations of
8−500 μg/mL of isotretinoin. In sterile 96-well microtiter
plates, 100 μL of the drug solution (in 40% dimethyl sulfoxide,
DMSO)/SLN-dispersion/NLC-dispersion/blank SLN-dispersion/blank NLC-dispersion/40% DMSO solution was diluted
with broth and added to wells containing 100 μL of bacterial
suspension in broth. To adjust the interference by nanoparticle
components, a parallel series of mixtures with uninoculated
broth was prepared. Triplicate samples were performed for each
test concentration. After incubation for 48 h at 37 °C under
anaerobic conditions, the quantum of microbial growth was
determined by absorbance at 600 nm using a microplate reader
(Biotek Instruments, Winooski, VT, USA). Aqueous solution of
clindamycin phosphate was also studied analogously to serve as
the control owing to its marked antimicrobial activity against P.
acnes.24 MIC was taken as the lowest concentration of a test
compound (i.e., ITR) which inhibited the growth of P. acnes.25
2.5. Drug Permeation Studies. Hairless Laca mice were
employed for the skin permeation studies on Franz diffusion
cells (M/s Permegear, Inc., PA, USA). After sacrificing the
animals, the hairs on the dorsal side of animals were removed.
The skin was harvested, freed of adhering fat layers, and
mounted on Franz diffusion cells having a cross-sectional area
of 3.142 cm2 and receptor volume of 30.0 mL. The diffusion
medium in the receptor compartment was composed of
Isotonic Palitzsch Buffer26 containing Tween 80 (2.7% w/w)
and ethanol (20.0% v/v). The assembly was maintained at 37 ±
1 °C with the help of thermo-regulated outer water jacket,
while the diffusion medium was stirred continuously using a
magnetic stirrer. Various formulations (ITR-SLN gel, ITR-NLC
gel, and commercial gel), each containing ITR equivalent to 0.6
mg, were applied onto the mice skin in the donor compartment.
Aliquots of 1 mL each were periodically withdrawn at
suitable time intervals from the sampling port and replaced with
an equal volume of fresh diffusion medium to maintain the
constant receptor volume. The samples were analyzed by a
validated reverse phase high-performance liquid chromatographic (RP-HPLC) method.27 ITR was quantified at 355 nm
using a liquid chromatograph LC-2010CHT (Schimadzu,
Japan), equipped with a UV detector and a software LC
Novel drug delivery systems are known to enhance the
overall performance of the drug at the target site vis-à-vis the
conventional dosage forms.17 Solid lipid nanoparticles (SLNs)
and nanolipid carriers (NLCs) are nanocolloidal systems
composed of biocompatible lipids.18,19 The biocompatible
lipid-based carriers can transport the drugs to the target site
and maintain drug concentrations higher than that with the
conventional formulations.2,20 These agents do not employ
solvents like dimethyl sulfoxide (DMSO), which are commonly
employed in other topical products as penetration enhancer(s)
or solubilizer(s). Such penetration enhancers are reported to
cause dermal irritation and at times, serious side effects.2
ITR is now-a-days also prescribed in the topical forms and is
believed to affect all of the causative mechanisms of acne,
including infestation by P. acnes.10 The hypothesis of ITR
antimicrobial activity against P. acnes has not yet been proved in
vitro or in vivo. Apart from this, it is a newly reported fact that
use of novel carrier systems can result in substantial
antimicrobial activity of the drug even at lower concentrations.2,21 Hence, the present study endeavors to establish the
antimicrobial activity of ITR against P. acnes and to study the
influence of encapsulation in nanocarriers SLNs and NLCs on
the skin transport characteristics, as well as on the minimum
inhibitory concentration (MIC). The developmental studies
have been published elsewhere along with antiacne activity,
biocompatibility, and biochemical evaluation.22,23
2.1. Materials. Isotretinoin (ITR; M/s Ipca Laboratories
Ltd., Ratlam, India), phosphatidylcholine (PC; Phospholipon
90 G; M/s Phospholipid GmbH, Nattermannallee, Germany),
clindamycin phosphate (M/s Psycoremedies, Ludhiana, India),
and Compritol 888 ATO GF3123 (M/s Gattefosse, Hauptstrasse, Germany; M/s Colorcorn, Mumbai, India) were
provided ex-gratis by the respective organizations. Isopropyl
myristate (IPM; M/s LobaChemie, Mumbai, India), butylated
hydroxy toluene (BHT; M/s SD. Fine Chemicals Ltd.,
Mumbai, India), Anaerogas Pack 3.5 L (M/s Hi Media Lab.
Ltd., Mumbai, India), brain heart infusion media (BHI; M/s Hi
Media Lab. Ltd., Mumbai, India), and tocopherol acetate (M/s
E-Merck (India) Ltd., Mumbai, India were procured from the
corresponding sources. Microbial culture of P. acnes (MTCC
1951) was procured from Institute of Microbial Technology
(IMTECH), Chandigarh, India. All other chemicals employed
in various studies were of analytical grade and were used as
such. Ultrapure water (Milli-Q Integral system; M/s Merck
Millipore, Billerica, USA) was used throughout the study.
2.2. Preparation of ITR-Loaded Nanocarriers.
2.2.1. ITR-Loaded SLNs. The microemulsification method was
employed for the preparation of ITR-loaded SLNs.22 In brief,
ITR (50.0 mg) and the lipophilic antioxidant (BHT; 138.7 mg)
were dissolved in ethanol (6.0 g). The PC (208.5 mg) was
dispersed in a portion of water along with Tween 80 (6.5 g)
and sodium metabisulfite (SMBS; 0.5 g). Compritol (674.0
mg) was melted at 70 °C. The lipid phase, aqueous phase, and
drug solution were mixed at same temperature to give a clear
microemulsion. The hot microemulsion formed was poured
into the remaining portion of water (i.e., about 80% of the
total), previously cooled and maintained at 4 °C. The resulting
mixture (100 g) was stirred continuously at 3000 rpm for 20
2.2.2. ITR-Loaded NLCs. Drug (50.0 mg) and BHT (BHT;
138.7 mg) were dissolved in ethanol (5.0 g). PC (0.6 g) was
dx.doi.org/10.1021/mp300722f | Mol. Pharmaceutics 2013, 10, 1958−1963
Molecular Pharmaceutics
Figure 1. TEM photomicrographs (a) ITR-loaded SLNs (2 000 000×); (b) ITR-loaded NLCs (1 000 000×).
solutions through a reverse phase C-18 column of length 150 ×
4.6 mm, 3 μ ODS1 Spherisorb (M/s Waters Corporation,
Milford, USA). The mobile phase consisted of glacial acetic
acid 1.96% v/v: methanol (27:73 v/v), delivered at a flow rate
of 1.0 mL/min. The permeation flux values were calculated for
all of the formulations by plotting the amount of drug released
per unit surface area vs time. The slope of the regressed line of
the straight portion of the graph was reported as the
permeation flux value.28
2.6. Skin Retention Studies. Skin mounted on the
diffusion cell was removed carefully after completion of
permeation studies. The formulation remaining adhered on
the skin was scrapped off carefully with the help of a spatula
and subsequently analyzed for drug content. The cleaned skin
tissue was washed thrice with ultrapure water and dried using
lint-free cotton swab. The skin was chopped into small pieces
and macerated in methanol (5 mL) for 24 h for complete drug
extraction to take place. After filtering the solution through a
membrane (0.45 μm), the filtrate was analyzed using the
validated RP-HPLC technique.
2.7. Dermatokinetic Modeling. The excised skins of
Wistar rats were used for the studies. The skin tissue was
prepared as discussed in section 2.5. Franz cell diffusion
assembly was used for the studies as discussed under
permeation studies with a dose of application equivalent to 1
mg of ITR. In this case, the whole skin was removed from the
Franz cell at the respective sampling times. The skin was
washed thrice to remove any adhering formulation and
subsequently soaked in hot water (60 °C) to detach the
epidermis from dermis.29,30 Both of the sections were chopped
into small pieces, separately, and macerated in methanol (5
mL) for 24 h for complete drug extraction to take place. After
filtering the solution through a membrane (0.45 μm), the
filtrate was analyzed using the validated RP-HPLC technique.
The obtained data were fitted into one-compartment open
model, as per the following equation (eq 1)
Cskin =
K p·Cmax
(K p − Ke)
concentration achieved in skin, and Ke is the skin elimination
constant. Win-Nonlin Ver 5.0 software was employed to
compute various dermatokinetic parameters , namely, Kp, Cskin
Ke, and Tskin
curve (AUC0−6h) using the Wagner−Nelson method. Data
analysis was accomplished using nonlinear function minimization employing Gauss-theorem algorithms built into the
software. Statistical validity of the results was discerned on
the basis of minimization of various model fitness parameters
like Akaike Information Criterion, Schwartz Criterion, sum of
squares due to residuals, and maximization of Pearsonian
correlation coefficient.
2.8. Estimation of Drug in Blood Portal. Six animals
(Healthy male Wistar rats, 9−10 weeks old, 280−320 g) each
were divided into three groups. Animals were caged and fed as
per the norms of Institutional Animal Ethics Committee. Group A
received marketed product while Group B and Group C
received ITR-SLN gel and ITR-NLC gel, respectively. Each
group received ITR equivalent to 0.6 g by topical application on
the shaven skin. After dose application, serial blood samples
(0.5 mL aliquots) were withdrawn from the tail vein at 0, 2, 4,
and 6 h postdosing. Plasma was harvested by centrifugation and
stored at −20 °C until analysis.31
2.9. Ethical Compliance. All animal protocols were duly
approved by Institutional Animal Ethics Committee, Panjab
University, Chandigarh, India (ref. letter no. CAH/09/70;
2.10. Statistical Analysis. Multiple comparisons were
made using one-way ANOVA followed by post hoc analysis
using Student's t test. Statistical significance was considered at P
< 0.05.
3.1. Formulation Details. Average particle size of both the
colloidal carriers (i.e., SLNs and NLCs) was found to be below
100 nm, i.e., 75.3 nm (SLNs) and 80.0 nm (NLCs),
respectively. Entrapment efficiency of these carriers was
found to be above 75%, i.e., 89.49% for SLNs and 78.60% for
NLCs. Both the carriers possessed significantly high magnitude
of zeta-potential, i.e., −22.4 mV for SLNs and −15.0 mV for
NLCs, the negative sign corroborating the anionic surface
(e−K pt − e−Ket )
where Cskin is the concentration of drug in skin at time t, Kp is
the dermal permeation constant, Cmax
is the maximum
dx.doi.org/10.1021/mp300722f | Mol. Pharmaceutics 2013, 10, 1958−1963
Molecular Pharmaceutics
components of the nanocarriers and better interaction of the
carriers with the skin components.17 The significant difference
(p < 0.001) in the drug transport characteristics of SLNs and
NLCs both may be assigned to the difference in the
composition and physicochemical properties of these lipidic
colloidal carriers.
3.4. Skin Retention Studies. Skin retention values (μg
cm−2 ± SD) from the studied formulations were observed as
charge on the colloidal carriers. ITR-loaded nanoconstructs
were observed to be spherical in nature, as confirmed by
transmission electron microscopic (TEM) photographs (Figure
3.2. Antimicrobial Activity. The order of MIC values was
observed to be as follows:
ITR(125.0 μg/mL)
> ITR−SLNs
≈ ITR−NLCs(62.5 μg/mL)
ITR−NLCs(22.98 ± 1.98)
> ITR−SLNs(15.79 ± 1.32)
> clindamycin phosphate(31.75 μg/mL)
> commercial gel(9.78 ± 0.59)
It is clearly vivid from the results that ITR also possesses its
own antimicrobial activity with MIC value of 125.0 μg/mL visà-vis 31.75 μg/mL for the control antibiotic, i.e., clindamycin
phosphate. Interestingly, incorporation of ITR in the lipidbased nanocarriers resulted in marked 50% reduction of MIC
to 62.50 μg/mL for both ITR-SLNs and ITR-NLCs. This twofold enhancement in the antimicrobial activity of the nanoentrapped ITR can be ascribed to the better interaction of the
lipid-based nanocarriers with the bacterial cell wall, resulting in
increased contact time and sustained delivery of the drug to the
3.3. Drug Permeation Studies. Figure 2 shows the drug
permeation profile of ITR from various studied systems.
Nanocolloidal carriers, namely, SLNs and NLCs, were able to
significantly (p < 0.001) enhance the skin deposition of ITR in
comparison to that of the commercial product. This can be
attributed to the fusion of the biocompatible drug loaded
carriers with the skin components and formation of micro drug
reservoirs.20 These micro drug-depots in the skin ensure the
sustained drug delivery to the target site in a controlled manner.
3.5. Dermatokinetic Modeling. Figures 3 and 4 show the
distribution of drug in epidermis and dermis of the Wistar rat
Figure 3. Graph showing the amount of drug present in the epidermis
of Wistar rats at various time points.
Figure 2. Drug permeation profile of ITR from various studied
formulations across Laca mice skin.
Percent drug permeation (±SD) after 24 h was found to
observe the following order:
ITR−SLN gel(84.91 ± 4.25)
> ITR−NLC gel(75.21 ± 3.76)
> commercial gel(43.88 ± 2.19)
The pattern of skin permeation flux values (μg cm−2 h−1 ± SD)
was found to observe the following:
ITR−SLN gel(19.75 ± 1.21)
> ITR−NLC gel(14.39 ± 1.37)
Figure 4. Graph showing the amount of drug present in the dermis of
Wistar rats at various time points.
> commercial gel(9.66 ± 0.89)
The extent of permeation, as reflected from the corresponding
permeation flux values, were found to be significantly (p <
0.001) greater in case of nanocarriers vis-à-vis the marketed
product. This can be attributed to the biocompatible
skin, respectively. Delivery of ITR in the skin layers by SLNs
and NLCs was found to be significantly greater (p < 0.05) than
that from the commercial gel. However, the drug delivery
dx.doi.org/10.1021/mp300722f | Mol. Pharmaceutics 2013, 10, 1958−1963
Molecular Pharmaceutics
Table 1. Various Dermatokinetic Parameters (Mean ± SD) of ITR Topical Formulations in Epidermis and Dermis of Wistar
Rats (n = 6)
commercial gel
dermatokinetic parameters
AUC0−6h (μg cm−2 h)
max (μg cm )
Tmax (h)
Kp (h−1)
Ke (h−1)
176.99 ± 12.31
156.84 ± 7.23
0.35 ± 0.02
34.36 ± 2.97
1.03 ± 0.45
496.84 ± 31.09
109.62 ± 9.98
2.25 ± 0.02
0.89 ± 0.07
0.18 ± 0.01
192.89 ± 14.14
114.86 ± 9.65
0.55 ± 0.03
7.48 ± 0.79
0.98 ± 0.08
381.72 ± 20.12
88.97 ± 3.98
2.11 ± 0.02
0.67 ± 0.05
0.32 ± 0.02
142.31 ± 7.98
26.21 ± 0.04
0.75 ± 0.03
0.38 ± 0.02
0.33 ± 0.02
97.33 ± 7.81
25.93 ± 1.45
1.42 ± 0.08
1.46 ± 0.07
0.27 ± 0.01
edged. Generous help provided by Mr. Aman Singla in
dermatokinetic data treatment is highly appreciated.
potential in the skin layers by NLCs was observed to be
superior to that of SLNs. Table 1 gives the numeric values of
AUC0−6h, Cskin
max, Tmax, skin penetration rate constant (Kp), and
skin elimination rate constant (Ke).
The nanocolloidal systems (SLNs and NLCs) significantly
enhanced the ITR delivery in the skin layers vis-à-vis the
commercial product (p < 0.001 each). AUC of ITR was also
found to be significantly greater (p < 0.001 each) in the dermis
than in the epidermis for both of the colloidal carriers. The
results, therefore, unequivocally vouch that the carriers
delivered ITR to the dermis layer quite efficiently ascertaining
adequate drug supply to the sebaceous glands, i.e., the afflicted
site of acne.
3.6. Estimation of Drug in Blood Portal. Plasma samples
of all of the studied groups were found to be devoid of retinoids
after single dose administration at the studied sampling
intervals. Therefore, the developed nanocarriers and the
marketed product possibly will not cause the side effects
related to the systemic distribution of ITR like psychological
The current studies successfully embarked upon the demonstration of the antimicrobial activity of ITR against the acne
causing pathogen, i.e., P. acnes. The findings indicate highly
encouraging results of the lipidic nanocarriers, i.e., SLNs and
NLCs, on the antimicrobial activity of ITR. These lipid-based
nanocarriers not only decreased the MIC of ITR but also
helped to retain the drug at the desired sites like various skin
layers. Therefore, lipid-based naocarriers hold immense
promise to enhance the efficacy and dermal delivery of
antimicrobials in a quite strategic manner. Significant findings
of the work can be rationally extrapolated to other similar drugs
and analogous lipidic carriers.
Corresponding Author
*E-mail: firstname.lastname@example.com. Fax: 91-172-2541142.
The authors declare no competing financial interest.
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Authors are thankful to M/s Ipca Laboratories, Ratlam, MP,
India for generously providing the gift samples of ITR where to
M/s Gattefosse, Germany along with M/s Colorcon, India and
M/s Phospholipid GmbH, Nattermannallee, Germany, for the
ex-gratis supply of Compritol 888 ATO GF3123 and
phospholipids, respectively. Financial grants obtained from
University Grants Commission (UGC), New Delhi, India and
M/s Ipca Laboratories, Mumbai, India are gratefully acknowl1962
dx.doi.org/10.1021/mp300722f | Mol. Pharmaceutics 2013, 10, 1958−1963
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lipase production by propionibacteria in vitro. Antimicrob. Agents
Chemother. 1982, 21, 39−43.
(25) Tsai, T.; Wu, W.; Tseng, J.; Tsai, P. In vitro antimicrobial and
anti-inflammatory effects of herbs against Propionibacterium acnes. Food
Chem. 2010, 119, 964−968.
(26) Diniz, D. G. A.; Alves, C. P. I.; Castro, N. C.; Rodovalho, L. F.
F.; Benfica, P. L.; Valadares, M. C. Isotretinoin-containing liposomes:
obtention, characterization and in vitro cytotoxicity on leukemia cells.
Appl. Cancer Res. 2008, 28, 106−111.
(27) European Pharmacopoeia, European Directorate for the Quality
of Medicines. Council of Europe, Strasbourg, France, 2010; pp 2293−
(28) Bonina, F. P.; Montenegro, L.; Scrofani, N.; Esposito, E.;
Cortesi, R.; Menegatti, E.; Nastruzzi, C. Effect of phospholipid based
formulations on in-vitro and in-vivo percutaneous absorption of
methyl nicotinate. J. Controlled Release 1995, 34, 53−63.
(29) Fujii, M.; Bouno, M.; Fujita, S.; Yoshida, M.; Watanabe, Y.;
Matsumoto, M. Preparation of griseofulvin for topical application
using N-methyl-2-pyrrolidone. Biol. Pharm. Bull. 2000, 23, 1341−
(30) Kligman, A. M.; Christophers, E. Preparation of isolated sheets
of human stratum corneum. Arch. Dermatol. 1963, 88, 702−705.
(31) Jensen, B. K.; McGann, L. A.; Kachevsky, V.; Franz, T. J. The
negligible systemic availability of retinoids with multiple and excessive
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acne vulgaris. J. Am. Acad. Dermatol. 1991, 24, 425−428.
dx.doi.org/10.1021/mp300722f | Mol. Pharmaceutics 2013, 10, 1958−1963
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This super cute 90's inspired oversized cropped shirt is the perfect over layer.
Delilah is made from a lightweight corduroy that is 100% Organic cotton. She has 2 front pockets and is fully reinforced around the cuffs and collar, giving a slightly heavier feel in parts, adding to the quality of this amazing top!
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Worn with our limited editions 'Sage'
Delilah can be worn as a shirt or as a summer jacket.
Lulu is 5'9, size 8 and wears the small
Click here to see size guide
Customer Reviews
Organic 'Delilah' Cropped Oversized Shirt in Mint Green
Great colour and love where it sits on me. Fab!
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Totally in love with the cropped shirt. Looks awesome matched with my Lucy&yak pants or over a dress... perfect for Aussie spring! Now I just need to get me some Lucy&yak overalls in my life!!

subset: commoncrawl


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Hilton Head Prep's girls lost 57-30 to visiting Calvary Day on Tuesday.
Ella Clark scored 12 points to lead the Dolphins, while Avery Brothers and Annie Braun added six apiece.
HHP (0-4) hosts The King's Academy on Friday.
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greg1c greg1c is offline
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- Network Engineer
- Current Honda vehicles
2010 Acura RDX Turbo AWD/Tech 67k miles - Daily Driver
2013 Accord EX-L I4 Auto 53k miles Black Pearl - Wife's car
2005 Acura TSX Auto 208k miles - Youngest Daughter
2013 FIT Sport Auto - 24k miles - Oldest Daughters car
Former Honda Vehicles
2001 Acura MDX Totaled t223k
1991 Accord LX auto sold 185k miles
1995 GSR sold @220k miles
1991 Civic SI Crushed by a tree during a tornado 1997
1989 Prelude SI soldr @44k miles
1986 Civic 5 speed sold @165k miles
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|07:22 AM - RickBlaine mentioned greg1c in post No AC in car
...Did you check what greg1c mentioned? What abo...
|02:51 AM - greg1c mentioned enne in post Selene's Official Modification Thread ('99 Accord LX)
...er motor is working enne but the solenoid is ...
|07:01 PM - tc3sean mentioned greg1c in post Tried to start car and dashboard started to go crazy displaying messages
greg1c these accords use gr...
|02:17 PM - Miker mentioned greg1c in post 09 V6 Multiple Misfire, Cyl 1 misfire after changing plugs
...a bad sparkplug.(as greg1c posted) The ceramic...
|01:39 PM - jimijam mentioned greg1c in post 07 Accord EX-L A/C Recharge Questions
greg1c: thanks for the info...
|12:31 PM - KW2004Accord mentioned greg1c in post 06 Accord power flash when ac turns on
greg1c knows more about ele...
|09:41 AM - BenzAccord mentioned greg1c in post 7th Gen Accord with dead tranny
...2 using Tapatalk greg1c, first of all, thank...
|11:13 AM - BenzAccord mentioned greg1c in post 7th Gen Accord with dead tranny
... to it. Yes I read greg1c's post and he may be...
|05:19 AM - greg1c mentioned Kompressor_82 in post Defective AC condenser
...rld already. Hey Kompressor_82 this looks like your...
|04:10 AM - greg1c mentioned enne in post Defective AC condenser
As enne said, a new car and ...
|04:12 PM - greg1c mentioned enne in post Over heating in stop/go traffic
Also, enne had a similar discus...
|04:30 PM - Miker mentioned greg1c in post PSA: Another possible reason to not use a dealer or quicky lube place for service
greg1c That must be very si...
|05:28 AM - greg1c mentioned t-rd in post 2013 Accord Sport missing screws for downpipe. Where to buy?
What t-rd said will work, so f...
|06:18 AM - greg1c mentioned t-rd in post Grind/hum noise after tire rotation
As t-rd said, if you have a ...
|05:15 AM - ember1205 mentioned greg1c in post 07 Accord EX-L A/C Recharge Questions
...d necessary in it. greg1c linked to a couple o...
|03:49 PM - Ronch mentioned greg1c in post TPMS light on can?t get to go off
..., same type, etc as greg1c already suggested? ...
|05:02 AM - enne mentioned greg1c in post Car wont start after driving a while.
...gn would fix it, as greg1c mentioned.
|06:07 AM - bobbo mentioned greg1c in post P1157 food for thought ?
...patalk THANK YOU greg1c - I only wrapped the...
|04:54 AM - enne mentioned greg1c in post Automotive-based YouTube channel ideas?
Hi all, So greg1c gave me an idea; to ...
|09:12 AM - 17wop6mtcr2 mentioned greg1c in post Charging system issue? Starter failing?
...ing courses haha greg1c see above where I ta...
|09:14 AM - BLCKFLSH quoted greg1c in post CVT Blues, think I got Jiffy Lubed
There has been several case...
|07:36 AM - Slimezilla quoted greg1c in post Push button start on 2014 exl
[QUOTE=greg1c;6718147]If I underst...
|10:19 AM - greg1c quoted Asis in post 2015 Accord 4 warning lights went off: TPMS, VSA, EPS, CEL
hi, i have honda accord 2...
|04:27 PM - BenzAccord quoted greg1c in post temperature gauge reading in winter? 4-cylinder Sport
The 9th gens are slow to he...
|07:40 PM - Cjlarson14 quoted greg1c in post The multi-quote button is here! Rejoice!!!
MODERATOR EDIT: Your thoug...
|03:41 PM - Cjlarson14 quoted greg1c in post 2016 Honda Accord Sport Front End Rattle
A couple of things it could...
|03:19 PM - BigStuck quoted greg1c in post 2004 4 Cyl Accord Wont Start
You can always upload the v...
|02:05 PM - Accordianguy quoted greg1c in post 04 Honda Accord Ex Coupe Steering Wheel Air Bag Replacement
If this was my car, I would...
|04:43 AM - greg1c quoted Accord7200 in post Car dies while driving
Hi does anyone have another res...
|05:36 PM - SoCal_EXLV6 quoted greg1c in post Where EX-L Coupe Bluetooth HFL/HFT Module Location?
The Honda part # 39770-T2A-...
|05:19 PM - Masonvoodoo quoted greg1c in post Need help with Jumped Timing Chain
If I did not have Hondabond...
|01:11 PM - Masonvoodoo quoted greg1c in post Need help with Jumped Timing Chain
To reassemble you will need...
|12:09 PM - Masonvoodoo quoted greg1c in post Need help with Jumped Timing Chain
Step by step you mean? Basi...
|07:46 AM - greg1c quoted MiragePilot in post So what did you do to your 7th gen today?
You did not have to reprogram an...
|07:01 PM - diesel quoted greg1c in post 07 Honda Accord EX V6 Idle Problems, RPM Issues
I would do this, do a compr...
|08:02 AM - CDsDontBurn quoted greg1c in post car shutting off
i have a 2001 Honda accord ...
|05:58 PM - hand2handWombat quoted greg1c in post more power steering
It is possible that the rea...
|03:44 PM - WDHewson quoted greg1c in post New timing chain keeps jumping teeth
I am not sure what you mean...
|07:18 AM - WDHewson quoted greg1c in post New timing chain keeps jumping teeth
I am not sure of the engine...
|06:02 AM - Warren1086 quoted greg1c in post 2010 V6 Accord Sedan- P0420 Code Options
Misfires will kill a Cataly...


text:
Featured Garage/Yard Sale
Yard Sale Saturday April 27th, 8 - Noon
Iron outdoor furniture, planters, art (water paintings, landscapes etc.), records - especially older Jazz vinyl in good condition, furniture (end tables, painted wine holder, stereo cabinetry, bric a brac), jewelry. Everything must GO!! Easy parking.… → Read More
Featured Estate Sale
Wonderful Westford Estate Sale Thursday April 25th Antiques, Fine Home Furniture & Decor, Art & Craft Supplies & So Much More!! Don't Miss It!
Best Rate Cleanouts & Estate Sales is hosting a Wonderful Westford Estate Sale on Thursday April 25th from 9am-2pm. You will find antiques, furniture, living room furniture, HDTV flat screen television, art studio with art supplies, easels, original art & oil paintings, books, lamps, bedroom furniture, bureaus, end tables, costume jewelry, some gold… → Read More
Featured Estate Sale
Impressive Manchester By Sea Estate Sale Friday April 26th Antiques, Early Worlds Fair Mechanical Bank, Old Paintings, Civil War Sword, Ham Radios, Tools, Collectibles & More! A Must Not Miss!!!
Best Rate Cleanouts & Estate Sales is hosting an Impressive Manchester by the Sea Estate Sale on Friday April 26th from 9am-2pm. This estate certainly has some unique & interesting items to offer! To start off you will find a rare 1893 World's Fair Columbus Mechanical Bank, Civil War sword, art, old oil paintings which includes Wesley Webber… → Read More
Featured Estate Sale
Huge & Amazing Dedham Victorian Estate Sale April 27th & 28th Antiques, Old Toys Musical Instruments Violins Gibson Guitar Coins Jewelry Furniture Books Art Tools Car Parts Packed 3 Story Barn! Wow!
Best Rate Cleanouts & Estate Sales is hosting an Absolutely Huge Dedham Victorian & 3 story barn Estate Sale on Saturday April 27th & Sunday April 28th from 9am -2pm Both Days. This home is jam packed from top to bottom! To start off you will find a fabulous selection of musical instruments, which includes an early Gibson 4 string acoustic… → Read More
Toys, Tools, Bikes, Clothes, Furniture, Household, Collector Items, Toy Cars, NASCAR, Exercise Equipment, Gym Equipment… → Read More
Giant Yardsale - House Cleanout!!
Giant Yard Sale - Saturday April 27 9am-3pm. 30 Daniel Drive, Abington. Lots of kitchen stuff (appliances, silverware, you name it - toaster, toaster oven, food dehydrator, pots and pans), furniture, bookcases, men's clothing, kids clothing, toys, tools, snowblower, ladders, gardening stuff, knick knacks, collectibles, golf clubs, leaf blower, nice… → Read More
Winchester Downsizing Online Auction - Brooks Street
WILL SELL by Thursday May 02, 2019 7:30 PM Winchester Downsizing Online Auction - Brooks Street This online auction features Caleca Italian Dinnerware, Silver plated tea service, Fireplace set, Set of Vermont Precision maple bunk beds, Laura Ashley Hereford Chaise Lounge, Waterford crystal champagne glasses, TKO 50 lb Punching Bag, Bose Sound Dock system,… → Read More
Many miscellaneous items… → Read More
ALL items priced at $1, $5 or $10 (really!) Liquidating a LARGE 30+ year cache of Collectible Action Figures; Kitchenware/Household items; Geocaching swag/supplies; Vera Bradley; Car hub caps & floor mats. NO Early Birds.… → Read More
Yard Sale!! Saturday April 27th 8am-12noon
Furniture, Coca cola memorabilia, outdoor patio and garden décor. Christmas in April: lights, ornaments… → Read More
6 families in the Devonshire Place/ Lenox Circle neighborhood are participating.… → Read More
Natick Flea Market On Sunday May 5, 2019
The Natick Flea Market is an outdoor event that will be held on SUNDAY ONLY, MAY 5, 2019 at 95 Speen St., Natick, in the parking lot of the Natick Elks, which is located between Route 135 and Pond St. Vendors will be selling items such as furniture, oriental and other rugs, toys, games, CDs, jewelry, bone china, porcelain, LPs, metal ware, glassware, model… → Read More
Chairs, coffee tables, bureau, college fridge, lots of household items, kids sports equipment… → Read More
Winchester Moving Online Auction - Everett Avenue
WILL SELL by Thursday April 25, 2019 7:15 PM Winchester Moving Online Auction - Everett Avenue This online auction features artwork, exercise equipment, a ping pong table, mahogany dining room table and much more! Please view catalog and pictures online at MaxSold… → Read More
HUGE SALE! WHEN: SAT 4/27/19 & SUN 4/28/19 TIME: 10AM-4PM WHERE: 40 ROBBIE ROAD AVON, MA (LOCATED IN AVON INDUSTRIAL PARK NEAR THE PARKER DRIVING SCHOOL) FOR INQUIRIES OR DIRECTIONS CALL 508-521-9541 FREE TOYS FOR THE KIDS. EVERYTHING MUST GO! DELIVERY AVAILABLE!… → Read More
Big one family yard sale: electronics, tools, dartboard, vintage backgammon set, tools, little girls items, household/kitchen items, craft supplies. Something for everyone.… → Read More
Neighborhood yard sale on Edgelawn & Marose Ave in North Chelmsford MA… → Read More
Indoor Yard Sale - 42 Summer Street, Maynard
Indoor Yard Sale Monday - Friday 9:30 a.m. - 4:00 p.m. 42 Summer Street, Maynard, MA "Inventory arriving daily, Shop us often!"… → Read More
Decor Change And Clutter Buster!
Yard Sale featuring tons of lovely seaside cottage decor, lamps and ceiling lights, sea glass bottles, artwork, picture frames, glassware, shells, baskets. Large aqua enamel lobster pot. Beautiful, quality items. We're changing our decor style a bit and these things are pretty but it's time for them to have a new home! If you like seaside chic,… → Read More
Moving! Good Stuff Cheap On 4/27-4/28
New Keurig machine ($35); TUMI leather suitcase ($40); MiniFridge ($40); Ikea Kallax unit ($15); Christmas ornaments and costume jewelry (most things are $1); pillows of all description, some from Crate & Barrel and West Elm; hats; clothes; space heater; dehumidifier; lamps; garden tools; weights; books; free stuff. No early birds, please, and cash… → Read More
YardSales.net is the fastest growing yard sale site, with 1,341 sale photos and 47 garage sales in Cambridge, Massachusetts. YardSales.net offers you the best list of Cambridge yard sales every week.
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text: B bctjr1993 Sep 17, 2018 #21 Messages 92 Likes 176 Location Kansas City, MO jesse's mom said: Very helpful, thanks for all the tools. I have been using just earplugs. Click to expand... Of course! Just stick with this. It was a miracle for me and many others I know who have tried it


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In addition I had inform them that I was closing the checking account that they had been taking the payments from so they were not to charge that account going forward. That I wouod get back to them with the new information for my new checking account. I purposely had not given them the information because I was researching what my recourse was so when it came time for the payment I hadn't given the information and on their website it's it's showing that I owe them money for fees and they wanted their money so what did they do they charged my old account which had nothing in it so I was hit with a NSF fees and every 3 days I get charged a fee for the negative balance but they got their payment and I've got payment it went to fees for the accounts that they lost the settlement because couldn't make payments to my creditors Beach they had drained my account for all the fees
Debt management and debt settlement are two very different repayment options. A debt management plan provides regular monthly payments to your creditors. In contrast, a debt settlement program often encourages you to stop sending payments to creditors, which can result in serious consequences. The risks associated with debt settlement programs are important to understand. Below is a summary of things you should consider before choosing debt settlement as an option.
Other times, we just become sick of living paycheck to paycheck, and decide we want a better life — and that's OK, too. You shouldn't have to confront disaster to decide you don't want to struggle anymore, and that you want a simpler existence. For many people, becoming debt-free the hard way is the best and only way to take control of their lives and their futures.
It is also important to be aware of any debt settlement and debt relief and elimination scams that may be going around. Always research the companies or the debt relief programs you are interested in and make sure they are offering legitimate and reliable services. Also, make sure that the debt consolidation program you work with informs you of all the risks that may be associated with the particular programs they are offering.
I was in touch with National debt relief from past 2 years and trying to decide if I want to go this path or not by talking to few agents . Recently I had bad experience with few agents that I talked with rude attitude thnking that I am not a serious client or wasting the time by not enrolled into their programs. I think as a customer you have a right of thinking and asking or talking to few agents or looking for other options also . One of the agent Richi S. was very rude and offensive in talking to me and said I am totally a waste of time and not serious before even getting into the details of my current situation. Yes of course I had submitted the request few times thinking of enroll but did not take the decision . They cannot force or assume that every one who ask the adivse does not necessary have to enroll l or cannot submit the request again because they are not serious!. Very bad and rude customer skills. please train them to be kind and professional towards clients with their talking.
Make sure you are working with an NFCC-member nonprofit credit counseling agency like InCharge Debt Solutions. Nonprofit credit counselors provide impartial financial advice that has your best interest in mind. A nonprofit debt management program will have low fees and work to secure interest rate reductions on your credit card debt, so that you are able to pay off your debt by making consistent affordable payments.
If you choose to do your counseling over the telephone, we'll connect you with a certified credit counselor who will do the following: collect information about your income, assets and expenses. They will then pull a copy of your credit report and review your debts with you. Based on your income, assets and debts, your credit counselor will make a debt relief recommendation to you which may include bankruptcy, a debt management program and/or recommendations for how to reduce items in your budget to help you pay off your debt faster.
Through a nonprofit credit-counseling agency, you can work with a counselor to resolve your financial problems on your own, says Bruce McClary, vice president of public relations and external affairs at the National Foundation for Credit Counseling. Or you can enter what's called a debt management plan. Through that plan, you can consolidate your credit card payments and get the cards' interest rates reduced, making your financial obligations easier to tackle.
Get a second job or work overtime, if available. I'll be blunt, second jobs are no fun, but they sure do help pay the bills. Think of how tired/stressed/soulless you feel after your 9-5 already; now imagine getting in your car, battling rush hour traffic, and putting in another four hours from 6 to 10. Then you get home around 11, just in time to watch the Daily Show and pass out.
Since debt management plans are individually tailored to each consumer, one plan can be wildly different than the next. McClary said your plan can vary depending on how much debt you owe, your current interest rates and payments and how your interest rates and fees are negotiated down. This is a huge benefit for consumers since debt management plans come with specific advice instead of blanket solutions that may or may not work.
Credit card forbearance programs are offered by companies. Once again, the major lenders including Chase, Bank of America, Citibank, Discover Card, and others offer credit card forbearance programs that may allow consumers to delay monthly payments from six months to over a year. These programs may also lower interest rates, reduce a customer's minimum monthly payment, or waive all fees.
Credit card hardship programs are also more widely available. Citibank, Bank of America, Discover Card, JP Morgan Chase, Capital One, GE Money Bank, and others offer consumers assistance with paying bills and their debts. There are many different versions of these credit card hardship programs, and each bank has their own take on it. They do not advertise these plans to customers, and there are certain steps that individuals need to take in order to apply for help. Find how to get help with paying credit card debt from a hardship program.
Imagine, for example, that you have $20,000 in credit card debt and $10,000 in other non-mortgage debt. You might set yourself a goal of paying it all off in two years. (Set a specific time frame, too, lest you keep extending your deadline.) You can set sub-goals, too, such as having a quarter of it and half of it paid off by certain dates. Write down the goals and post them where you'll see them.
"Clients who are able to stay with the program and get all their debt settled realize approximate savings of 50% before fees, or 30% including our fees, over 24 to 48 months. All claims are based on enrolled debts. Not all debts are eligible for enrollment. Not all clients complete our program for various reasons, including their ability to save sufficient funds. Estimates based on prior results, which will vary based on specific circumstances. We do not guarantee that your debts will be lowered by a specific amount or percentage or that you will be debt-free within a specific period of time. We do not assume consumer debt, make monthly payments to creditors or provide tax, bankruptcy, accounting or legal advice or credit repair services. Not available in all states. Please contact a tax professional to discuss tax consequences of settlement. Please consult with a bankruptcy attorney for more information on bankruptcy. Read and understand all program materials prior to enrollment, including potential adverse impact on credit rating."
This is the last-ditch solution if your financial situation has become so overwhelming that there doesn't appear to be a way out. Bankruptcy offers a "fresh start" though with lots of restrictive conditions. You can file for either a Chapter 7 bankruptcy, which cancels your debts, or a Chapter 13 bankruptcy, which sets up a 3-5 year repayment plan to eliminate your debts.
The Financial Consumer Agency of Canada (FCAC)[8] advises Canadians to do their research and find a trustworthy organization and a qualified counsellor. They suggest making sure an agency is in good standing with a provincial or national association. They recommend looking carefully at the agency's advertising to see if it sounds too good to be true. Claims or misrepresentations to look out for can include repaying only a fraction of your debt, quickly fixing your credit score, or claiming to be part of a government program. They also suggest consumers inquire about an agency's services, costs, and counsellor qualifications.[9] The FCAC has also warns Canadians to be careful of companies offering to help them pay off their debt or repair their credit. Things to watch out for include guarantees to solve debt problems and using high interest loans to pay off debt. Some of these companies also claim that they can file a consumer proposal on behalf of a consumer. However, the FCAC points out that only a qualified licensed insolvency trustee can help someone with a consumer proposal or bankruptcy.[10]
In fact, certain aspects of a debt management plan will have a positive impact on your credit score. These aspects are the amounts owed, payment history, and inquiries for new credit. Your payment history, which makes up 35% of the FICO credit score, will have a positive impact assuming your payments are made every month. In terms of amounts owed, which makes up 30% of the Fico score, this aspect will be positively impacted as the accounts are paid down.


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The Mystery of the Horses of the Sun at the Temple Entrance
Kathleen Kenyon's discovery in cult center illuminates puzzling Biblical passage
The last great Yahwistic religious reform before the fall of Jerusalem in 586 B.C. was carried out in Judah by King Josiah in about 621 B.C.
The Bible tells us that Josiah "did what was right in the eyes of the Lord, following in the footsteps of his forefather David" (2 Kings 22:2). Josiah repaired the Temple, discovered a book of the law which most scholars believe to be the book of Deuteronomy, and suppressed pagan religions and pagan shrines both in Jerusalem and elsewhere in the kingdom (from "Geba to Beersheba", the Bible says).
The Bible is very specific in its description of the pagan cult objects and practices which Josiah destroyed and suppressed. One of the things Josiah destroyed has, however, long been a puzzlement to scholars. In 2 Kings 23:11, we are told that Josiah "destroyed the horses that the kings of Judah had set up in honor of the sun at the entrance to the House of the Lord."
Kathleen Kenyon, the eminent British archaeologist, excavated a cult center near Jerusalem which may have solved the puzzle.
The cult center which Dr. Kenyon excavated was just outside the wall of the city—where the Canaanite cults no doubt flourished in the 8th–7th century B.C.
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Comments /{{hitsCtrl.values.hits}} Views / Wednesday, 12 September 2018 00:00
President Maithripala Sirisena is to participate in an international summit organised by United States President Donald Trump on tackling the global illegal narcotics trade.
Ports and Shipping Minister Mahinda Samarasinghe, addressing media at the Sri Lanka Freedom Party headquarters yesterday, said that President Trump would be holding an international summit with the participation of world leaders on extensive and long-term measures that could be adopted by nations to address the illegal drug market.
"President Donald Trump has extended an invitation to President Sirisena and other world leaders to participate in this summit on tackling international drug trafficking. President Sirisena has agreed to take part," the Minister said.
He added that the President had been an ardent supporter of eradicating the narcotics trade and related issues in Sri Lanka.
"This is an issue that President Sirisena has been continuously speaking of. Every month he speaks with officials from each district on the current status and programs on curbing drug peddling and use. As Sri Lanka is becoming the transit hub of South Asia, this international summit organised by the US will help us share methods to curb the narcotics menace," Minister Samarasinghe said.
Furthermore, the Minister said that President Sirisena would be giving a speech on the late South African President Nelson Mandela on 24 September during the Nelson Mandela Peace Summit at the 23rd United Nations (UNGA) General Assembly.
In addition, President Sirisena will be addressing the UNGA on 25 September. (SG)
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CI Design for Niche Digital-Product (LOGO - EBOOK - LANDINGPAGE GRAPHICS - WEBSITE HEADER)
Budjetti €30-250 EUR
CI Design for a niche website. A Logo and Ebook Cover (Simple / black and white) background graphic for landingpage, Header graphic for WP site / Title and profile pic for Facebook.
Fixed price 60€ for the first batch of graphics.
Continuos, paid revisions possible.
Include the keyword "hammer" at the start of your bid to show you have read the project details.
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hammer We have read the project brief regarding Logo and Ebook Cover (Simple / black and white). We provide everything full corporate identity from company logo Design, Business Cards, flyer, poster, Brochure. we wi Lisää
15 freelanceria on tarjonnut keskimäärin %project_bid_stats_avg_sub_26% %project_currencyDetails_sign_sub_27% tähän työhön
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Tracing space: Do Ho Suh at Contemporary Arts Center, Cincinnati
Bill Clinton was one of the first people to visit Do Ho Suh's latest exhibition – a major survey presenting the Korean-American artist's acclaimed work that opened at the Contemporary Arts Center, Cincinnati this weekend. The former US president paused for a photo op in front of the exhibition – entitled 'Passage' – before continuing his tour of the Queen City.
It's as good a promotional picture as you could hope to get ahead of an opening; and in itself created an interesting dialogue with the artist's oeuvre and his studies of the mutable and phantasmagorical qualities of space. They are imaginings of the absent things that have passed through and yet somehow leave a trace, as well as of the possibilities of other elements to surprise and transform.
Do Ho Suh is best known for his ruminations on the idea of home, informed by the artist's own migrations and the places he has lived in (South Korea, Europe and the US). This survey, however, is rooted specifically in the CAC's Zaha Hadid-designed building and the ways in which 'the structure could be navigated as a single, porous passage'.
'Do Ho was inspired by the idea of a building as a singular, unending passageway and the works selected for the show have amplified that quality within his own work,' explains curator Steven Matijcio. 'It highlights the purposefully partial nature of his practice and the transgressive qualities that subvert the fixity of home with the ubiquity of transition and the infinity of movement.' In the context of today's crisis, these reflections resonate deeply and far beyond the place they began.
Two years in the making, the artist worked closely with Matijcio to conceptualise the exhibition, after a visit to the space in 2014. 'Do Ho worked tirelessly to fit new and existing works into the space so that they feel magically site specific. Working with him has been a profound experience and his work has created an unparalleled synergy with the space, and both the building and the work have opened up one another to inspiring new readings.'
Among the work on show are two new video installations, Passage and Stroller – created specifically for the exhibition – as well as architectural works; these rubbings, works on paper, scale models and documentary materials presented alongside the installations give an unprecedented insight into Do Ho's way of working. Matijcio emphasises their importance: 'By having the rest of the work in context it returns and highlights the very human underpinning and infrastructure of this work. As much as it pushes to ideas of abstract movement, this work is a meeting place for us to realise we are part of much larger sequences, series, timelines and collectives.'
- Information
'Do Ho Suh: Passage' is on view until 11 Septemer. For more information, visit the Contemporary Arts Center's website
Photography courtesy the artist and Lehman, Maupin, New York
- Address
Contemporary Arts Center
44 East 6th Street
Cincinnati, OH 45202
View Google Maps
- Telephone
- 1.513 345 8400


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The University of Cambridge Intellectual and Developmental Disabilities Research Group (CIDDRG) and the Down's Syndrome Association (DSA) are undertaking a joint consultation in researching dementia in Down's Syndrome. They want to know what you think about people with Down's Syndrome taking part in clinical trials.
The Family Carer Support Service are delighted to start a new project this autumn for adult siblings of people with a lifelong learning disability and/or autism. They say....
Over the past year we have had an increase in requests from adult siblings for sibling groups. In response to this, Sibs will be developing a network of face-to-face adult sibling support groups across the UK. This project is supported by the MariaMarina Foundation.
Mutual support for you as a sibling
Attached are the issues taken to the Partnership Board at its annual review meeting on 23rd November 2015. For this presentation, we selected out the most significant issues raised during the last twelve months, highlighting on each slide when the issue had been raised before, and making proposals for solutions whenever possible. Cllr Viv Kendrick, the lead Member for Adult Services was present for this presentation.
Attached are the issues raised at the Partnership Board on 28th September 2015.
It is a few months since this website was updated. Many apologies for this. The updating process depends on one willing volunteer, who has been unable to do it for a little while, but is now back in the frame. So aplogies that there has been a gap in news and documents being added to the site. Things can now improve again !!
Attached are the issues taken to the Learning Disability Partnership Board on behalf of carers on 6th July 2015
The issues taken to the Learning Disability Partnership Board on 11th May 2015 are attached.
The issues taken by carers to the Learning Disability Partnership Board on 13th April 2015 are attached.
The Government has produced a consultation paper with a variety of proposals to improve the lives of people with mental health needs, learning disabilities and autism. This comes in the light of all the reports arising from the Winterbourne View scandal. Family carers are invited to send in their comments by 29th May 2015.
In place of handouts at the event, the following web-links are offered as a means of returning to the content of Luke's talk.
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