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Mr. Speaker, yesterday for the first time the Minister of Industry finally admitted freely that he accepted a free gift by going fishing at the Irving fishing lodge. A forced, half-hearted, eleventh hour apology is simply not good enough.
I ask the Deputy Prime Minister, does he still care about integrity in government? Has he intervened on behalf of Canadians, and when will the Minister of Industry be asked to resign?

subset: commoncrawl


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FORT WAYNE, Ind. – – Thanks to lockdown defense, third-seeded Purdue Fort Wayne took down sixth-seeded Lindenwood 25-12, 25-21, 25-19 on Arnie Ball Court on Saturday (April 13). The Mastodons held the Lions to a -.011 hitting percentage for the match. This is the lowest hitting percentage against the Mastodons by a conference team since 2004, when Clarke hit -.078.
This was the first MIVA Tournament win for the Mastodons since 2014.
Colton Stone finished with three aces, moving him into 10th place in program history in career aces with 99. He is one away from moving into a tie with Jeff Ptak for ninth. Michael Keegan had two digs to move into a tie with Tom Juhnke for ninth place all-time in career digs with 626.
The 'Dons dominated the first set offensively, rallying to a .520 hitting percentage (14-1-25). Both Tony Price and Stone had four kills on six attacks. The Mastodons had 12 digs and two blocks to hold Lindenwood to .038 hitting. The 'Dons never trailed the Lions in the first set, jumping out to a 17-7 lead that put the frame far out of reach.
In the second set, Lindenwood's defense set in, holding the 'Dons to .161, but the Purdue Fort Wayne defense continued with 12 more digs and two more blocks. The Lions hit .091 for the frame. This was the closest set throughout, as there were 14 ties and seven lead changes. The 'Dons used a 3-0 push late to go up 22-19, which included one of Stone's aces.
After taking a 2-1 lead in the last set, the Mastodons never trailed. Stone's service led the way in an 8-0 run after the Lions took the first point of the set. The Mastodons ran out the set by leading 24-13, but the Lions would not leave without a fight. They took six straight points behind Logan Nash's serve, which included three blocks from All-MIVA Second Team member Connor Hipelius. Pelegrin Vargas picked up his sixth kill of the night on the one that ended the match. The Lions hit a match-low -.147 in the third set.
Four Mastodons had at least six digs: Price (6), Vargas (7), Kolbie Knorr (7) and Stone (9).
Lindenwood falls to 9-19 and ends the season. The Mastodons improve to 17-11 and will await the result of second-seeded Loyola and seventh-seeded Ohio State to determine which team they will play in the MIVA Tournament. If Loyola wins, the 'Dons will travel to Chicago to face the Ramblers. If Ohio State wins, Purdue Fort Wayne will welcome the Buckeyes to Arnie Ball Court. In either scenario, the match will be played on Wednesday, April 17.


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Do Osage Orange Trees Grow in Michigan?
Osage orange (Maclura pomifera) trees, native to Texas, Arkansas, Oklahoma and Louisiana, have naturalized in southern Michigan. They grow in the Michigan counties of Hillsdale, St. Joseph, Berrien, Kalamazoo, Oakland, Livingston and Kent. Early Michigan settlers planted the thorned, up-to-60-foot trees as nearly impenetrable barriers in place of fences.
Osage orange (Maclura pomifera) trees, native to Texas, Arkansas, Oklahoma and Louisiana, have naturalized in southern Michigan. They grow in the Michigan counties of Hillsdale, St. Joseph, Berrien, Kalamazoo, Oakland, Livingston and Kent. Early Michigan settlers planted the thorned, up-to-60-foot trees as nearly impenetrable barriers in place of fences.
What Eats Osage Orange?
While the seeds of Osage orange fruits are edible, most people don't eat them or any other part of the fruit. Getting to the seeds involves removing a gooey husk that surrounds each seed. If you pick up a bruised fruit, it may leak a sticky, white juice that irritates the skin and causes a rash.
Osage orange fruits strongly appeal to squirrels. They animals tear apart the hedge apples to get at the small seeds. The squirrels must first get rid of the slimy husk surrounding each seed before they can enjoy their prize. You can tell squirrels are eating the fruits if you see piles of the shredded fruit underneath the trees.
At least four stem-borer insects find the woody parts of the trees an edible source, including the mulberry borer, painted hickory borer and red-shouldered hickory borer. Scale insects also attack the tree, feeding on opening buds and new leaves.
How to Decorate With Osage Orange
Paint the osage oranges with a variety of designs, or in solid, bright colors. Use craft stencils to make designs such as ivy vines, flowers and paisleys. Allow the paint to dry for approximately eight hours.
Place the twigs in the wicker basket and arrange them so the foliage hangs over the edge of the basket. Arrange the painted and dried osage oranges on top of the branches so they show through the foliage.
Place the decorative basket on a table or shelf in your home. Alternatively, osage orange baskets make wonderful centerpieces at picnics and barbecues.
How Fast Does the Orange Osage Tree Grow?
Osage orange trees grow rapidly, up to three feet a year, to an average mature height of 30 feet. Compare this to oak trees which grow one to two feet a year. Osage orange trees are named after the Osage tribe.
What Is an Osage Orange?
The Osage orange (Maclura pomifera) is native to eastern Oklahoma and northern Texas, but it spread across the Great Plains as settlers in the 1800s brought the tree with them to use for hedgerows.
The average Osage orange tree grows to about 30 feet tall, and the trunk has a diameter of 1 1/2 feet. The tapered leaves are shiny and turn yellow in the autumn. The fruit is a light green, wrinkled ball approximately 6 inches across, and it remains on the tree after the leaves fall off.
Only female Osage orange trees bear fruit. The tree can act like a shrub if it is planted alone but remains a tree if planted among others of its kind.
Originally, the Osage orange tree was planted and pruned to create thick, tight hedges. The wood is very strong and resistant to rot, so it is used for fence posts and makes good bows. The fruit can be used as a natural insect repellent.
The Osage orange has sharp thorns, which can make it difficult to prune.
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Sangini Syrup:
Sangini Syrup is a wonderful Ayurvedic preparation for women that Is very effective as uterine tonic for menstrual discomforts, including PMS (Premenstrual syndrome). Sangini Syrup helps balance proper flow of menstrual fluids for discharge. Sangini syrup is Nourish and balance hormones, emotions, mind, liver, blood, hemoglobin, digestion, bones and reproductive system. Sangini Syrup is aLso useful in aLl age groups after 14 years and is an excellent female tonic.
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text:
Case Study : The Interprofessional Team Models Essay
Case Study : The Interprofessional Team Models Essay
Length: 1228 words (3.5 double-spaced pages)
Rating: Better Essays
Essay Preview
The Methadone Program
Harm reduction is a concept that refers to policies, programs, and practices that aim to reduce the harms associated with the use of psychoactive drugs in people unable or unwilling to stop (Syme, Browne, Varcoe, & Josewski, 2011). Research has shown that Methadone therapy is the most cost effective strategy for reducing major ris...
... middle of paper ...
...s with a higher affinity to relieve the symptoms of opioid withdrawal (Melle, 2016). At Rosthern Hospital the methadone program has been able to address the needs of the community by successfully treating many cases of opioid addiction. Nurses are able to support these patients through their treatment by monitoring their progress through the treatment. Interprofessional roles and scope of practice are respected and utilized in the methadone program. The methadone program at rosthern hospital is an example of successful interprofessional collaboration, where health care professional come together to achieve a common goal for successful patient care. Overall, the interprofessional team in the methadone program has demonstrated their own success by the successful treatment of opioid withdrawal, and by addressing the needs of a community suffering from opioid addiction.
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How Interprofessional Collaborative Practice Improve Patient Outcomes Essay
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Great experience. The staff and owner were very quick in responding for an appointment. The vehicle assessment report provided via email was detailed and professional. The work was completed quickly and within the estimated cost. And they even dropped the car off at my house when finished since I was out of town and couldn't pick it up. Highly recommend them!
Best in the area! Pros who care!
Great service. Clear explanation of work required.
There is a reason this shop has 5/5 stars on every review forum. Head to toe professional. I wasn't a paycheck to these guys, they cared about my safety and I was lucky to stumble across them. Look no more, your go-to shop should be Fine Tuned Auto.
An honest shop that she's great work!
Clean professional shop! Waiting room was perfect. Felt like they really cared about the car and the customer. We'll be back.
I have been a customer of Fined Tuned for about 3 years. The work done on my car has always been thorough and professional. Prices for work are fair and equitable. I highly recommend Fine Tuned for your automotive needs!
I received quick, performance restoring, basically stellar service. Definitely returning for future needs.
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This places serves good pizza in large portions. The staff is friendly and you don't have to wait long for your food. We had a pizza with fennel sausage with almost no sausage on it, so that could have been better.
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.


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Comments on: 2008 Chevrolet Cobalt SS
Learn more about the 2008 Chevrolet Cobalt SS - Article. Read a review and see pictures of the 2008 Chevrolet Cobalt SS at Car and Driver.
Such great performance for the money. I really like improvements they made for 2008. I would take the one with the smaller spoiler though because I hate those big ugly wings. They also lower the top speed of the car according to a test I read. Maybe it was this one? I have to read it again after this comment.
I got Forza 4 and when i saw they had the Cobalt SS, i never stopped playing it to this day


text:
Phone number: 1800 64....
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Cover design: Adrian Morgan
Cover art: Shutterstock
Copyright © 2013 by Laurence G. Weinzimmer and Jim McConoughey. All rights reserved.
Published by Jossey-Bass
A Wiley Imprint
One Montgomery Street, Suite 1200, San Francisco, CA 94104-4594 www.josseybass.com
No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted under Section 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400, ...


text:
- Name
- Laquinimod
- Accession Number
- Type
- Small Molecule
- Groups
- Investigational
- Description
Laquinimod is an immunomodulator developed by Active Biotech and produced by Teva Pharmaceutical Industries. It is currently under development in phase III trials for treatment of multiple sclerosis as an oral therapy, like fingolimod. It has been shown to reduce disease activity on magnetic resonance imaging and to be well tolerated orally.
- Structure
- Synonyms
- Laquinimod
- External IDs
- Product Ingredients
Ingredient UNII CAS InChI Key Laquinimod sodium 4H914M0CSP 248282-07-7 JWHPPWBIIQMBQC-UHFFFAOYSA-M
- Categories
- CAS number
- 248281-84-7
- Weight
- Average: 356.81
Monoisotopic: 356.0927701
- Chemical Formula
- C19H17ClN2O3
- InChI Key
- InChI
- InChI=1S/C19H17ClN2O3/c1-3-22(12-8-5-4-6-9-12)19(25)16-17(23)15-13(20)10-7-11-14(15)21(2)18(16)24/h4-11,23H,3H2,1-2H3
- IUPAC Name
- 5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
- CCN(C(=O)C1=C(O)C2=C(C=CC=C2Cl)N(C)C1=O)C1=CC=CC=C1
- Indication
Investigated for use/treatment in multiple sclerosis.
- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
Hepatic. Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod.
- Laquinimod 5-chloro-N-ethyl-4-hydroxy-N-(4-hydroxyphenyl)-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
- Laquinimod 5-chloro-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
- Laquinimod 5-chloro-N-ethyl-4-hydroxy-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
- Laquinimod 5-chloro-N-ethyl-4,8-dihydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
- Laquinimod 5-chloro-N-ethyl-4,7-dihydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
- Laquinimod 5-chloro-N-ethyl-4,6-dihydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
- Route of elimination
- Not Available
- Half life
- Not Available
- Clearance
- Not Available
- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.Learn more
Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.Learn more
Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.Learn more
- Drug Interactions
Drug InteractionUnlock Additional Data (R)-warfarin The metabolism of (R)-warfarin can be decreased when combined with Laquinimod. (S)-Warfarin The metabolism of (S)-Warfarin can be decreased when combined with Laquinimod. 3,5-diiodothyropropionic acid The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Laquinimod. 4-hydroxycoumarin The metabolism of 4-hydroxycoumarin can be decreased when combined with Laquinimod. 5-androstenedione The metabolism of Laquinimod can be decreased when combined with 5-androstenedione. 6-Deoxyerythronolide B The metabolism of Laquinimod can be decreased when combined with 6-Deoxyerythronolide B. 6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Laquinimod. 7-ethyl-10-hydroxycamptothecin The metabolism of Laquinimod can be decreased when combined with 7-ethyl-10-hydroxycamptothecin. 9-aminocamptothecin The metabolism of 9-aminocamptothecin can be decreased when combined with Laquinimod. Abatacept The metabolism of Laquinimod can be increased when combined with Abatacept.Additional Data Available
- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.Learn more
- SeveritySeverity
A severity rating for each drug interaction, from minor to major.Learn more
- Evidence LevelEvidence Level
A rating for the strength of the evidence supporting each drug interaction.Learn more
- ActionEvidence Level
An effect category for each drug interaction. Know how this interaction affects the subject drug.Learn more
- Food Interactions
- Not Available
- General References
- Tuvesson H, Hallin I, Persson R, Sparre B, Gunnarsson PO, Seidegard J: Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator. Drug Metab Dispos. 2005 Jun;33(6):866-72. Epub 2005 Mar 11. [PubMed:15764719]
- Comi G, Pulizzi A, Rovaris M, Abramsky O, Arbizu T, Boiko A, Gold R, Havrdova E, Komoly S, Selmaj K, Sharrack B, Filippi M: Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet. 2008 Jun 21;371(9630):2085-92. doi: 10.1016/S0140-6736(08)60918-6. [PubMed:18572078]
- Yang JS, Xu LY, Xiao BG, Hedlund G, Link H: Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats. J Neuroimmunol. 2004 Nov;156(1-2):3-9. [PubMed:15465591]
- External Links
- PubChem Compound
- 54677946
- PubChem Substance
- 347827782
- ChemSpider
- 11444966
- ChEBI
- 134738
- ChEMBL
- Wikipedia
- Laquinimod
- ATC Codes
- N07XX10 — Laquinimod
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Completed Not Available Pharmacodynamics / Pharmacokinetics 1 2 Completed Treatment Crohn's Disease (CD) 1 2 Completed Treatment Huntington's Disease (HD) 1 2 Completed Treatment Lupus Arthritis 1 2 Completed Treatment Multiple Sclerosis, Primary Progressive 1 2 Completed Treatment Nephritis, Lupus 1 2 Completed Treatment Relapsing Remitting Multiple Sclerosis (RRMS) 1 2 Terminated Treatment Relapsing Remitting Multiple Sclerosis (RRMS) 1 3 Completed Treatment Disseminated Sclerosis 3 3 Terminated Treatment Relapsing Multiple Sclerosis (RMS) 2 3 Withdrawn Treatment Relapsing Remitting Multiple Sclerosis (RRMS) 1
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0438 mg/mL ALOGPS logP 2.77 ALOGPS logP 2.55 ChemAxon logS -3.9 ALOGPS pKa (Strongest Acidic) 5.02 ChemAxon pKa (Strongest Basic) -2.2 ChemAxon Physiological Charge -1 ChemAxon Hydrogen Acceptor Count 3 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 60.85 Å2 ChemAxon Rotatable Bond Count 3 ChemAxon Refractivity 97.31 m3·mol-1 ChemAxon Polarizability 35.31 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon
- Predicted ADMET features
Property Value Probability Human Intestinal Absorption + 0.983 Blood Brain Barrier + 0.8819 Caco-2 permeable + 0.6474 P-glycoprotein substrate Non-substrate 0.6369 P-glycoprotein inhibitor I Non-inhibitor 0.8987 P-glycoprotein inhibitor II Inhibitor 0.6333 Renal organic cation transporter Non-inhibitor 0.8013 CYP450 2C9 substrate Non-substrate 0.7842 CYP450 2D6 substrate Non-substrate 0.8278 CYP450 3A4 substrate Substrate 0.5998 CYP450 1A2 substrate Non-inhibitor 0.5961 CYP450 2C9 inhibitor Inhibitor 0.506 CYP450 2D6 inhibitor Non-inhibitor 0.8592 CYP450 2C19 inhibitor Inhibitor 0.5187 CYP450 3A4 inhibitor Non-inhibitor 0.6712 CYP450 inhibitory promiscuity High CYP Inhibitory Promiscuity 0.7445 Ames test Non AMES toxic 0.6719 Carcinogenicity Non-carcinogens 0.7705 Biodegradation Not ready biodegradable 0.9957 Rat acute toxicity 2.2971 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9702 hERG inhibition (predictor II) Non-inhibitor 0.6325
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
- Description
- This compound belongs to the class of organic compounds known as aromatic anilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with an aromatic group. They have the general structure RNC(=O)R', where R= benzene, and R = aryl group.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Anilides
- Direct Parent
- Aromatic anilides
- Alternative Parents
- Quinoline-3-carboxamides / Chloroquinolines / Hydroquinolones / Hydroxyquinolines / Hydroquinolines / Pyridinecarboxylic acids and derivatives / Pyridinones / Hydroxypyridines / Aryl chlorides / Tertiary carboxylic acid amidesVinylogous acids / Heteroaromatic compounds / Vinylogous amides / Lactams / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organochlorides / Organic oxides / Hydrocarbon derivatives show 11 more
- Substituents
- Aromatic anilide / Quinoline-3-carboxamide / Haloquinoline / Dihydroquinolone / Hydroxyquinoline / Chloroquinoline / Dihydroquinoline / Quinoline / Pyridine carboxylic acid or derivatives / HydroxypyridinePyridinone / Aryl chloride / Aryl halide / Pyridine / Heteroaromatic compound / Vinylogous amide / Tertiary carboxylic acid amide / Vinylogous acid / Lactam / Carboxamide group / Azacycle / Carboxylic acid derivative / Organoheterocyclic compound / Organooxygen compound / Organonitrogen compound / Organochloride / Organohalogen compound / Hydrocarbon derivative / Organic oxide / Organopnictogen compound / Organic nitrogen compound / Organic oxygen compound / Aromatic heteropolycyclic compound show 23 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- Uniprot ID
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
- Tuvesson H, Hallin I, Persson R, Sparre B, Gunnarsson PO, Seidegard J: Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator. Drug Metab Dispos. 2005 Jun;33(6):866-72. Epub 2005 Mar 11. [PubMed:15764719]
- Fernandez O: Oral laquinimod treatment in multiple sclerosis. Neurologia. 2011 Mar;26(2):111-7. doi: 10.1016/j.nrl.2010.07.027. [PubMed:21163185]
Drug created on March 19, 2008 10:49 / Updated on March 18, 2019 09:58


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Hemp oil can be found in many different delivery forms. Hemp oil can be consumed orally, applied topically or sublingually, or smoked via vaporization. Vaporization and sublingual application of hemp oil allows for a fast onset-of-action of the CBD, whereas pills and edible products can take 30 to 90 minutes on average to take effect. Topical hemp oil can be applied directly to areas of pain or inflammation, though it can also be absorbed into the systemic circulation.
Another way to think about the difference between the two plants is by comparing them to roses. There are so many different varieties of roses. They come in various shapes, sizes, and colors. Even though they differ in a great many ways, they are still roses and their genealogy can be traced back to the original rose plant. Much like yellow roses and white roses are to the original red rose, the hemp plant is a relative (a cousin) of the Cannabis sativa plant.
You can use Nutiva Organic Hemp Seed Oil in smoothies, salads, vegetables and pasta dishes. To conserve the essential fatty acids, we suggest you use it raw or gently heated. It's not suitable for frying. Hemp is loaded with all 20 amino acids, including the nine essential amino acids that are not manufactured in the body, and must come from food. Amino acids are essential for many metabolic processes, including building muscle tissue.
Health benefits: It has been commonly used to treat rheumatism and arthritis, tighten gums and muscles, as well as helping to stop hair loss. It reduces the chances of hemorrhage, increases urination and removal of toxins, relieves obstructed menstruation and regulates the cycle, expels phlegm & catarrh, repels insects, lightens skin tone, stimulates systemic functions, and generally tones up the body.
I have sporadic back spasms for year I see a chiropractor monthly for maintenance (it help) and deal with daily Knee & hip joint pain due to my job (heavy mechanic/steel work with lots of walking). after reading all the great reviews on CBD oil I want to get off the daily ibuprofen regiment and try CBD oil. I would like to try it as a gel cap but would like some advise on dosage size. I also want to know how often I should take the CBD treatments. any and all advise is appreciated
CBD shows promise in the treatment of anxiety disorders, according to a report published in the journal Neurotherapeutics in 2015. Looking at results from experimental research, clinical trials, and epidemiological studies, the report's authors found evidence that CBD may help treat generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. However, the authors caution that human-based research on CBD and anxiety is fairly limited at this point.
Thank you for reaching out to us. You could most definitely try our premium hemp oil drops or soft gels. Our premium hemp oil products are great for assisting with a lot of different things such as pain, inflammation, stress, anxiety, mood and sleep. I would start out with our 3x strength option that we have available, and the best method is the drops. You take the recommended amount of drops listed on the bottle, under your tongue. You let the drops sit there for 30 seconds. After the 30 seconds, you swallow the remaining oil in your mouth. Buy doing so this will enter your bloodstream to deliver faster results. Although, I would recommend talking to a doctor before going off any prescribed medicine.
Health benefits: It has been commonly used to treat rheumatism and arthritis, tighten gums and muscles, as well as helping to stop hair loss. It reduces the chances of hemorrhage, increases urination and removal of toxins, relieves obstructed menstruation and regulates the cycle, expels phlegm & catarrh, repels insects, lightens skin tone, stimulates systemic functions, and generally tones up the body.
You are likely very familiar with the dangers that prescription painkillers (and other pharmaceuticals) present. In fact, it's estimated that the majority of CBD oil users attempt to switch to the all-natural therapy for the precise reason of kicking prescription med habits, which all too often cause an overwhelming array of irritability, sleep disruption, digestive complications, and even thoughts of suicide.
Although having lots of different oils in the kitchen might seem like a good idea, James Perko says that idea can backfire. Over time, heat and light can impact oils' taste and quality. It's best to use one or two types of oil Store them in a cool, dark place and replace any that any smell bitter or "off." (Store grapeseed and walnut oils in the refrigerator; they quickly become rancid. The cloudiness in refrigerated oils will clear once they return to room temperature.)
^ Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira N, Iwasaki K, Fujiwara M (January 2008). "Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism". Brain Research. 1188: 157–64. doi:10.1016/j.brainres.2007.09.090. PMID 18021759.
CBD oil products can be somewhat expensive, which may be a barrier for individuals seeking treatment or relief from different conditions and disorders. cbdMD is a notable exception as far as price-point is concerned. cbdMD offers it's premium, non-THC oils at a large variety of concentrations (300mg-5,000mg) as well as sizes (30mL and 60mL) . These oils are priced at $29.99 for 300mg oils and $99.99 for 1,500mg oils; these price-points are significantly below average.
Hempseed is considered by leading researchers and medical doctors to be one of the most nutritious food sources on the planet. Shelled hempseed is packed with 33% pure digestible protein and is rich in iron and vitamin E as well as omega-3 and GLA. A recent report funded by the Canadian government states that hemp protein comprises 66% high-quality edistin protein, and that hempseed contains the highest percentage of this of any plant source. Unlike soy, hemp is not genetically modified, and it doesn't contain the anti-nutritional qualities commonly found in soy.
My mom has terminal metastatic breast cancer and her bone metastases are incredibly painful. Not only does this product keep her pain tolerable but it has also decreased her depression and anxiety significantly. She no longer has those ups and downs but finally feels GOOD. Thank you for giving my mom her quality of life back so we can truly enjoy our time with her. For reference she takes 1000 mg 2xday.
Peppermint oil calms the involuntary smooth muscle of the stomach, producing an antispasmodic effect, and improves the flow of bile. It can soothe discomfort associated with irritable bowel syndrome (IBS) and studies have shown that encapsulated peppermint oil can reduce IBS symptoms in nearly 80 percent of people who take it.[11] Peppermint oil is effective because it contains menthol that interferes with the movement of electrolytes across cell membranes, stopping involuntary contractions.[12]
Not only are essential oils popular, but they also have legitimate therapeutic uses — and the science to back them up.[2] Although the exact benefit depends on the oil in question, some have antimicrobial and anti-inflammatory properties. Others can affect cognitive function, mood, and memory. Some can even help alleviate stiff, sore muscles and joints.
As a healthcare professional I have realized over the years that most physicians and our healthcare system in general are all set up to focus almost entirely on symptoms and the disease state as a problem to treat, not prevent unfortunately. The training that most physicians receive is almost completely pharmacologicaly focused and consequently they treat patients almost as if they are a car to be fixed rather than as a living breathing being.
Lisa Sasson, clinical associate professor of nutrition at NYU Steinhardt, is obsessed with extra-virgin olive oil, and who can blame her. It's high in heart-healthy monounsaturated fats and a quality bottle can truly take you on a taste bud adventure. There's one catch with extra-virgin versus other grades of olive oil: It has a relatively low smoke point (325 to 375 degrees F), which means you may not want to use it for frying or roasting at temperatures above that smoke point. Additionally, cooking a good EVOO will break down its structural integrity which messes with both its flavor and nutrition, so you may want to save your fancy bottle for drizzling and finishing dishes. Find out just how to find your perfect bottle here.
A pilot study published in Complementary Therapies in Clinical Practice found that the use of aromatherapy as a complementary therapy helped to reduce anxiety and depression scales in postpartum women. Women between zero and 18 months postpartum were divided into either a treatment group that inhaled a blend of rose and lavender essential oils or a control group that didn't receive any type of aromatherapy. After four weeks, the women using aromatherapy had significant improvements in anxiety and depression symptoms compared to those in the control group. (12)
What is an essential oil? Typically created through the process of distillation — which separates the oil and water-based compounds of a plant by steaming — essential oils are highly concentrated oils that have a strong aroma. In fact, sometimes they are called volatile aromatic oils because of their high concentration of the aromatic compounds. (1) They also are simply called aromatherapy oils.
The teeth were then soaked in apple juice for 24 hours. All of the substances significantly decreased the decalcification of tooth enamel by apple juice compared to the control group. Clove oil was more effective than either of its active components alone. There was no statistically significant difference between the fluoride and clove oil treatment group.
Cbd Oil For Dog
Been using product for a few days now ,I'm about one my 6th dose. I noticed today my hand from nerve damage has not dropped anything or felt numb,or even trembled. Even axienty has been managable. However I'm taking 250mgs.I boosted it up to 500mgs.3 or 4 times daily ,of 250mgs. It seems to have best effect atleast today.It's cold and rainy which,is better than snow ,is my most hightened pain days.Today 4/24/18. Has been a God send! 1 pain and axienty day free ...Makes me a believer! I stand by this products effectiveness. Hope my review helps another soul,that lives with same aliments.
I quickly emailed him and in less than hour, i got a feed back from him and he directed me on how to purchase the medication cannabis oil and he told me the delivery logistics which i quickly responded to,after two days of procuring the oil, the oil was deliver to me as he promise me. immediately my son commenced with treatment with the cannabis oil as directed by the prescription manual.
Cbd Oil For Anxiety And Depression
The CBD vaporizer category is pretty crowded, but this CBD Vape Shot Kit from Alternate Vape continues to win the hearts of our customers, even over more expensive versions. The device itself is small, portable, lightweight, convenient, and easy to use. Simply add your favorite flavor, screw on the top, and you're ready to start vaping. It's the ideal starter kit for beginners new to CBD vaping, and it comes with everything you need: one e-pen, one USB charger, and one pre-loaded CBD cartridge.
The CBD oil we offer has a couple different applications. You can hold a sublingual dose under the tongue for 30-60 seconds (recommended for fastest absorption), apply the oil topically to your skin (can be applied directly to a problem area or mixed with your favorite moisturizer), or blend the oil in a health-conscious smoothie. We will include further dosing instructions with the product.
In the last 6 months, I have been experimenting with CBD & THC to treat the aforementioned. It's been an expensive experiment with some improvement, just not enough relief from the pain. I'm currently using 75 mcg of fentanyl transdermal, 30 mg Oxycodone 5x daily, muscle relaxers, arthritis pills, etc and they still don't get me out of bed most days.
The hemp oil in our product contains CBD which is a LEGAL cannabinoid from hemp. It contains minuscule amounts (parts per billion) of THC that COULD show up in a drug screen. PureKana cannot guarantee that you will or will not pass a drug screen due to the amount of variables. Our products contain less than .3% THC(.02% to be exact). Drug screens vary and some can be more sensitive than others. If you have to take a drug test, it is best to not use our product.
My article is just a summary of what scientists know right now. Knowledge will evolve–that's a good thing, right? If you want to make a serious decision about what oil is healthiest for you, don't take my word on it — talk to a doctor or dietitian. A lot of the information about nutrition peddled on the web is from manufacturers or people who work for them, and from fake experts with lots of letters after their names. Read a variety of trustworthy sources and don't be suckered by sweeping claims. If it sounds too good to be true, it usually is.


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Jessica Marais is a South African Australian television star, who rose to fame by Rafters and Love Child. She has starred in an Australian television series, Packed to the Rafters and has also co-starred on the American drama series Magic City.
The beautiful and talented actress got the opportunity to a play role in TV program Rachel Rafter in the Australian Comedy serial Packed to the Rafters.
Marais has won the Logie For "Most Popular New Female Talent " as well as the Prestigious Graham Kennedy awards for "Most Outstanding New Tallent" at the Logie Awards of 2009.
Apart from it, she has appeared in the films, Two Fists and One Heart, which movie released in March 2009.
Jessica Marais – Age
Jessica Marais was born on 29th Jan 1985 in South Africa, and she grew up in Canada and New Zealand before her family settled in Perth, Western Australia. She has reached the age of 33, and has an Australian nationality and belongs to the white ethnicity.
Read More: Brett Rossi Bio, Age, Affair, Net Worth, Instagram & Statistics
She was raised by her mother Karen, along with her siblings, Jessica and Clara after her father, Jony died from a heart attack.
For her education, she joined John XXIII college and then went to St. Hilda's Anglican School for Girls. She completed her graduation from National Institute of Dramatic Art in 2007.
Jessica Marais – Affairs
Jessica Marais is an unmarried woman, however, she is a mother of a daughter, Scout Edie Stewart. She gave birth to her daughter with her partner James Stewart. They were together for five years but separated. According to the source, she is possibly single at present time.
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You can go 40 days without food, 4 days without water, 4 minutes without air, but not a moment without hope. So grateful for hope-filled and faith-filled humans who have contagious kindness. Love transcends all barriers both internal and external, the world could do with more of it. ❤
Jessica Marais – Net Worth & Twitter
He net worth has been due to her dedication and hard work in the Entertainment Industry, and she has a net worth estimated to be $1.2 million until today.
Read More: Lee Da-hae Bio, Married, Husband, Boyfriend, TV Show, Dating
Marais is active on Facebook, Twitter, and Instagram. She has 2.4 K followers on Instagram, 655 followers on Twitter, and her Facebook has 2.3 K followers.
Jessica Marais – Body Features
Jessica Marais has a slim body with the body measurement of 36-24-36 inches and stands the height of 5 feet 7 inches tall. Sh3e has a body mass of 55Kg and has blue colored eyes and blonde hair.
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Can't believe I won a Logie last night..! @misstap thanks for being a stylish, eloquent, vixen legend and taking the speech plunge for me, I love you. And to @grantdenyer, your speech moved me to tears. And gives me strength. Courage in the quiet battle.. congrats mate. ⠀⠀⠀⠀⠀⠀⠀⠀⠀ To everyone who watched, made, and supported Love Child and The Wrong Girl.. my eternal gratitude and @tvweekmag thank you so much. Xxx


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We are seeking to appoint with immediate effect a
Full Time Temporary Teaching Assistant
to cover maternity leave
Grade 2/3: SCP 2 – 7 (dependent upon qualifications and experience)
Newark Orchard School is a thriving Area Special School, based on two sites. Preferably you will hold a recognised qualification and have experience of working in a school but training will be provided. The post is subject to an enhanced DBS check.
Details and application forms are available by e-mailing email@example.com or by sending an sae to Ellie Bravery, Newark Orchard School, London Road, Balderton, Newark, Nottinghamshire NG24 3AL or clicking on the links below
Closing Date: 15 May 2019 – 12 noon
Interviews: 22 May 2019
Grade 2 TA Job Description
Grade 2 TA Person Specification


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Astroneer Wiki now has a new admin I will be working on the wiki. This wiki will be complete in December before Astroneer is out
Currently this Wiki page is pretty empty and outdated.
I would like to edit this Wiki with all of the knowledge of my 100+ hours of playing the game. I believe i can contribute to this Wiki page and make it better than it is at this point in time.
What do you think?


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NOTE: * THIS PRODUCT currently ONLY AVAILABLE FOR LOCAL PICKUP IN SAN DIEGO, CALIFORNIA * When you order, we will contact you to make arrangements on when and where to pick up.
Everything you need to start brewing kombucha at home!
Kit includes:
- 2.25 gallon lead-free ceramic brewing crock
- Plastic dispensing spigot
- Organic black and green tea and organic sugar (enough to make a 1 gallon batch)
- Tea towel
- Thermometer strip
- Recipe card
Choice of crock color- white with blue stripes, or solid navy blue
Purchase with or without a SCOBY (kombucha culture)
- Kombucha culture and starter liquid to make your first 1 gallon batch of kombucha


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Description of 4310 NEFF LAKE ROAD, BROOKSVILLE, FL 34601
Beautiful Florida country styled home sitting on 10 private and secluded completely fenced acres. Built in 2004, this 3-bedroom, 3.5-bathroom 2 story home is 2,274 square feet located in the Spring Lake Area of Hernando County known for its rolling hills and beautiful countryside. This home has something that not many Florida homes have, a basement. Current owner is using this space as a workshop, but think of the possibilities that this space could be used for. Man cave, home theater anyone? Enjoy morning coffee on the wrap around porch and marvel at nature's beauty including the scenic Koi pond. The double paned picture windows throughout the house allows you to enjoy the wildlife and scenery from the comfort of your home. Relish drinking hot cocoa by your wood burning fireplace during the cold winter nights. These are just some of the features this home offers. The kitchen was upgraded with granite counter-tops, new farm sink, and fixtures. With the tiled floor, spills are easy to clean up. Plenty of counter space and cabinets round off this amazing kitchen. The home offers a central vacuum system with lifetime warranty upgraded 2 yrs. ago. The master bedroom is spacious with a Cedar closet and the master bath includes a Jacuzzi tub with separate shower. Detached over sized 2 car garage was built in 2012 at 875 sqft. Located on a paved Road and located just 8 miles from I-75 allows for an easy commute to Tampa or Ocala.
Directions to 4310 NEFF LAKE ROAD, BROOKSVILLE, FL 34601
From Spring Lake Hwy go W for .7 mile, N on Neff Lake Rd for .5 of a mile, turn E onto driveway, go to end of driveway.
Features of 4310 NEFF LAKE ROAD, BROOKSVILLE, FL 34601
- Dining Level: First
- Dining Room is 12x14
- Kitchen is 12x16
- Kitchen Level: First
- Living Room is 16x13
- Living Room Level: First
- Master bedroom is 12x14
- Master Bedroom Level: Second
- Number of rooms: 5
- Workshop
- Dishwasher
- Dryer
- Microwave oven
- Range
- Refrigerator
- Washer
- Gas fireplace(s)
- Woodburning fireplace(s)
- Ceiling fan(s)
- Central air
- Electric heat
- Garage dimension is: 40x30
- Garage spaces: 2
- Block exterior
- Fenced lot
- Improvement: sidewalks
- Lot acreage is: 10.00
- Lot dimension is: 660x660x660x660
- Lot has southern exposure
- Lot zoned: AG
- Outdoor storage
- Subdivision: ACREAGE
- Laminate flooring
- Smoke alarm
- Tile flooring
- Walk-in closet(s)
- Metal roof
- Basement
- Crawlspace
- Underground utilities
- Total square feet: 2274.00
- Shed
- Tax year: 2018
Mortgage Payments for 4310 NEFF LAKE ROAD, BROOKSVILLE, FL 34601
The approximate monthly Principal & Interest payment for this property would be $2,056. This payment is based on a 30-year loan at a fixed rate of 4.12 % with a down payment of $40,000. Actual lender interest rates and loan programs may vary.
Use our Mortgage Payment Calculator to determine a more exact payment estimate.


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Now imagine for a minute if any of us in the church could only do the first part of what Jesus said in John 14:12 Truly, truly, I say to you, whoever believes in Me will also do the works that I do; and greater works than these will he do, because I am going to the Father.
Just think of anything Jesus ever did. And that's what He said we would do. After grasping that, we could move onto better understanding the greater works which should sufficiently blow your imagination wide open if you consider the menu list of the former. While I could have made a separate menu for the greater works, for this example I simply added it as the last item on the menu. I wanted to focus on the easier stuff first, like raising the dead and walking on water.
Remember, items on this Menu are all things that you will be able to do. Doing is eating in the Father's House at the Father's table. Pick out your favorite choices so the servers in heaven can have them on the table for you when you sit. Doggie bags are available so you can take food home for others who have nothing prepared.
Nehemiah 8:10 Go your way, eat the fat, drink the sweet, and send portions to those for whom nothing is prepared; for this day is holy to our Lord. Do not sorrow, for the joy of the LORD is your strength.
Glory Kitchen Menu Specials:
- Turn water to wine (John 2:1-11)
- Heal the sick / oppressed (Matthew 8:14-15, Mark 1:32-34)
- Cast out evil spirits (Mark 1:21-27, Luke 4:31-36)
- Catch fish miraculously when no fish are around (Matthew 5:1-11)
- Make the paralyzed walk (Matthew 9:1-8, Mark 2:1-2)
- Stretch out withered hands (Luke 6:6-11)
- Calm raging storms on the sea (Mark 4:35-41)
- Heal blood issues (Matthew 9:20-22)
- Raise the dead (Matthew 9:18,23-26)
- Make the blind see (Matthew 9:27-31)
- Make the deaf hear, the mute speak (Matthew 9:32-34, Mark 7:31-37)
- Feed way over 9,000 people with only a few fish and several loaves of bread (Matthew 15:29-39; John 6:1-15)
- Walk on water (John 6:16-21)
- Pull money out of a fish's mouth to pay taxes (Matthew 17:24-27)
- Heal dropsy, leprosy, being crippled (Luke 13:10-17; 14:1-6; 17:11-19)
- Anything else you want! A blank check! The greater works! (Matthew 18:19; 21:22; Mark 11:24, John 14:13, 15:7, 15:16, 16:23-24; James 1:5, 1:17; 1 John 3:22, 5:14-15)
Disclaimer: All ingredients and spices used in all recipes are totally organic, non-allergenic, non-racist and all that stuff. They include: peace, joy, love, hope, faith, favor, willingness to yield, treating others above ourselves, humility, wisdom, revelation, knowledge of God (aka, knowledge of the glory), et al.
- Resurrection Consequences - April 20, 2019
- The Most Important Decision Of Your Life - April 19, 2019
- Passover Sacrifice 5779/2019 - April 16, 2019
- Preview: God's Spring Appointed Holidays 5779/2019 - April 14, 2019
- Turkey Begins Filling Ilisu Dam - April 10, 2019
- Egypt Will Fear Israel… God's Will - April 7, 2019
- MUST Have Control? Let It Go… Christine McDonald - April 5, 2019
- Ancient Chorazin Discovery - April 4, 2019
- Nathan-Melech, Servant to King Josiah - April 2, 2019
- Is Turkey the "Catalyst" that Breaks the World? - April 1, 2019


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Have you ever wondered just what a rabbit has to do with the resurrection of Jesus? Or what the word "Easter" really means? And, for that matter, what's with all the eggs? Could it be, as Jon Stewart once wondered, that it's because Jesus was allergic to eggs?
Alas, no. But how we got to all this egg and bunny business is nevertheless a cool and rather medieval story.


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Gettin' giffy with it
Our marketing team have been learning how to be cool!
You might have noticed that we have been jazzing things up on social media recently. We invited in Adam Koszary, gif-maker and social media extraordinaire to show us how to make gifs from images of our collection objects. Originally hailing from the Bodleian, we thought it was worth learning from the best!
Who painted this doggy and what's he doing?
It's been super fun so far as it's allowing us to look at our collection in a new way. By bringing 2D works of art to life we can inject a bit of fun into unusual pieces. Our main goal is to share information about Waddesdon and our collection, but we want to communicate on the internet's terms; this means being human and a bit silly at times! Gifs can also add value to our objects as they allow us to tell stories, fun facts or the intention of an image.
Who is this large-bellied moustachioed man straddling a barrel?
If you don't know what a gif is, think of the moving portraits in Harry Potter – a gif is basically a moving image or animation, without any sound.
Find out more about the construction of the Manor >
Check out what we've created so far and click through to visit the collection database and discover more about these fascinating objects.
What on earth are Marie-Antoinette and Louis XVI doing?
Do you have any ideas for some gifs that we can create? Let us know!
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