text:
I'm 5′ 2″ or so, and about 102 pounds. I'm 19. Not that long ago, I was only 94 or so, and I eat very healthy (lean protein, fruits, vegetables). My one "no-no" is Starbucks in the morning, but I've always done that, even when I was thin. I want to drop the 8 pounds I gained ASAP. I used to be very tone, and I feel like all that has gone away. What do I need to do. Please help.
My commitment to not eating animals, however, was faltering. I'd wake up and declare, "I'm a vegetarian today!" but it was sort of hard to keep the resolution. I'd sit with a friend and she'd order a steak and I'd say, "Umm . . . are you going to finish that?" and take a bite. "But I thought you were a vegetarian!" she would remind me, and I'd counter with, "But you can't eat all that. I don't want it to go to waste!" I'd use any excuse.
"The American Heart Association recommends that men eat less than 36 grams of added sugar and that women consume less than 24 grams. However, for optimal weight loss, I tell my male clients to consume less than 20 grams of sugar per day and I tell the women to consume less than 15 grams.The easiest way to cut back on the sweet stuff is by consuming less sugary drinks and dressings. Cut the sugar, lose the fat, regain your health and life." — Dr. Sean M. Wells, DPT, PT, OCS, ATC/L, CSCS
Also, men tend to lose weight where they need it most (read: belly), so it's often more immediately noticeable when overweight men start trimming down than when women do, as ladies' fat stores are typically more spread out, which is partly why they tend to lose weight at a slower pace than guys. Even basic, regular exercise -- ideally 30 to 60 minutes a day -- tends to reduce abdominal obesity, even if guys don't technically lose weight.
So this is about treating yourself like a total goddess and putting yourself first. And you deserve that kindness, my friend. I used to equate having self-worth with being selfish, but now I understand that taking care of myself is the most beautiful thing I can do. And quite frankly, I can't be a good actor, I can't be a good wife, friend, or mother (to my dogs) . . . I can't be a good anything until I've taken care of myself fi rst. So this kindness to yourself is paramount.
"The one trick I use now, which I should have been using all along, is the make dinner a no-carb meal. I'll do a vegan protein and vegetables, and no bread. I think carbs are important and good energy, but when I don't eat them at night, I wake up and I feel like my belly's flat first thing in the morning." — Carrie Underwood, who lost 30 pounds of baby weight in less than a year
A calorie is a calorie, the advice goes. Eat too many ... gain weight. Eat fewer ... lose weight. But many believe weight loss is more than a calorie equation, with so-called new-and-improved ways to lose weight being ever popular. Americans spend an estimated $42 billion annually on weight loss foods, products, and services. With that much money at stake, it's no surprise there are an overwhelming number of "fad" diets and other weight-loss products on the market.
Hey Adam, it's great to see you're leading a healthy lifestyle and reaping the benefits of a good diet and exercise. My question is, what do you recommend for someone who isn't overweight per se, but could still afford to lose a few pounds? I have less than 20 lbs that I need to lose before I get a flat stomach to start working on my abs. I'm a taller guy (above 6ft) if that makes any difference. What kind of exercise should I be doing?
Re-think date night. "It's really hard to find time to be together. People always say 'date night,' but it's hard to get out once a week and leave the kids and do that," says Delaney. "So what we do is rather than date night we try to have one or two days a week where we train together in the gym. We spend time as a couple together being active and doing active things with the family. One of our favorite things to do is walk around the city, we don't take cabs, we walk the whole city, window shop and have something to eat. When it comes to exercise, have fun and don't make it feel like it's a chore."
I am very much over weight. I am 44 years. I have tried many diet plan but failed maximum after 3 weeks. My weight increase very fast and I do not have thyroid problem. I am not junk food lover but occassionaly I take. Being over weight my knees pain after I walk even with slow speed. So skipping and aerobics as mentioned by you will be difficult for me. So can this diet plan still work on me?
Use weekly check-ins to celebrate small successes. Recognizing your wins keeps you motivated, says Delaney, who recommends checking in with yourself every Sunday about your progress for the week — specifically what went well. "When you did a good job, you should recognize that because that keeps you motivated," she says. "Then you can go back and reflect. It'll remind you of your progress and of the things that you did really well; we need that. Part of the sustenance of keeping with a goal is feeling good about yourself." Take five minutes each Sunday to complete this journaling prompt: What did I do well this week? What didn't go well this week? What can I do differently next week to improve?
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
What happens if you fast for a day? What happens if you don't eat for a day? While most people will feel hungry and possibly tired, there is also a range of other effects. In this article, learn about how the body starts to burn fat for energy and whether fasting for 24 hours can be a good weight loss tool. We also investigate the possible risks. Read now
Some popular beliefs attached to weight loss have been shown to either have less effect on weight loss as commonly believed or are actively unhealthy. According to Harvard Health, the idea of metabolism being the "key to weight" is "part truth and part myth" as while metabolism does affect weight loss, external forces such as diet and exercise have an equal effect.[44] They also commented that the idea of changing one's rate of metabolism is under debate.[44] Diet plans in fitness magazines are also often believed to be effective, but may actually be harmful by limiting the daily intake of important calories and nutrients which can be detrimental depending on the person and are even capable of driving individuals away from weight loss.[45]
Categories: English terms derived from Old FrenchEnglish terms derived from Medieval LatinEnglish terms derived from LatinEnglish terms derived from Ancient GreekEnglish 2-syllable wordsEnglish terms with IPA pronunciationEnglish terms with audio linksEnglish lemmasEnglish nounsEnglish countable nounsEnglish words following the I before E except after C ruleEnglish verbsEnglish transitive verbsEnglish terms with quotationsEnglish intransitive verbsEnglish terms with obsolete sensesEnglish adjectivesEnglish uncomparable adjectivesEnglish terms with usage examplesen:Governmenten:NutritionDutch terms inherited from Proto-GermanicDutch terms derived from Proto-GermanicDutch terms derived from Proto-Indo-EuropeanDutch lemmasDutch nounsDutch nouns with plural in -enLatvian lemmasLatvian verbsLatvian terms with archaic sensesLatvian first conjugation verbsLatvian first conjugation verbs in -tLatvian semi-palatalizing first conjugation verbsMiddle Dutch non-lemma formsMiddle Dutch contractionsNorthern Sami terms inherited from Proto-SamicNorthern Sami terms derived from Proto-SamicNorthern Sami terms with IPA pronunciationNorthern Sami 1-syllable wordsNorthern Sami lemmasNorthern Sami determinersNorthern Sami demonstrative determinersOld Irish terms borrowed from Medieval LatinOld Irish terms derived from Medieval LatinOld Irish terms derived from Ancient GreekOld Irish lemmasOld Irish nounsPortuguese terms derived from EnglishPortuguese terms with IPA pronunciationPortuguese lemmasPortuguese adjectivesSwedish lemmasSwedish nounsZhuang terms with IPA pronunciationZhuang lemmasZhuang nouns
In the section on why people become obese it mentions eating too much, sedentary lifestyle, and not sleeping enough. While I won't deny these are all reasons for an increase in weight, it fails to also mention medical conditions and medications. These are both areas that should not be left out and it seems this book was only targeted at people to try to make them feel bad about their weight gain so they'll want to lose weight. (which by the way is not a good technique of motivation, which is one of the things the book promises to provide). The thing is, while yes many factors leading up to obesity are based on our own habits and behaviors and if we want to lose weight we have to take responsibility for those. That's absolutely true. But I feel like this book is so caught up in that area that it's forgetting to share the entire story.
I am trying to lose AT LEAST 10 pounds in the next 2 weeks. I have been trying to lose 20 pounds for 3 months now and have only lost about 5 pounds. Whenever I lose weight I always end up gaining it right back. I don't know what to do anymore. I don't want to look good (even though that would be a bonus) but I just want to be happy with myself… I am 18, 122.4 pounds, and 5'1″. I eat healthy, I bike, run, or do step aerobics for 45-60 6 times a week for the past 3 months, and lost only 5 pounds… Help! Please!!
I am 29 years old and weight 149.80 lbs. I weighed 190 almost two years ago. I have been struggling trying to lose the last 25 lbs to reach my goal. My biggest problem is that I lose almost all of the weight from my upper body but none of the fat has budged from my under arm (jiggly arms), inner thighs, knees or calves. I'm at a lose as what to do now.
Spoon Guru nutritionist Isabel Butler (MSc, ANutr) recommends that "the best way to reduce weight and maintain the weight loss is by simply eating a balanced and healthy diet, without refusing yourself particular foods… If you do cut out foods, you need to make sure your diet is still balanced and you are getting the nutrients your body needs from other sources."
The consultants are not professionals in this field. They undergo a training course but are not trained therapists, registered dietitians, or exercise physiologists, so the advice and support that you receive will be limited to what they have been taught to say. If you are taking any medications or have any health conditions, it is best to work with trained professionals.
The two diet options that are currently available are the Flex Plan and the Core Plan. The Flex Plan is an updated version of the POINTS Food System in which the goal is to stay within your recommended amount of points each day. The POINTS value for foods is calculated based on the food's calories, fat, and fiber. Along with your weekly POINTS target you are also given a "Weekly Allowance" to use for indulging or special occasions.
The goal of the workout was to promote food storage to muscle instead of fat – this is especially important during your cheat days. During my cheat day, I will look to do the air squats + tricep extensions even if I'm eating out. I didn't go to the gym at all for this, instead, I just took a couple old 20lb dumbbells, a pair of 10lb dumbbells and a pull-up bar from home. If you don't have a pull-up bar don't buy one, simply exchange the exercise for a back row or seated back fly exercise. I also don't own a weight bench so no need to spend your money on that. What I've learned since losing even more weight is that these workouts are pretty important if you want to lose weight fast. They aren't necessary but they certainly do help shed some extra pounds by keeping the fat off, especially on your cheat day.
Over the past few years it has become clear that weight is an important health issue. Some people who need to lose weight for their health don't recognize it, while others who don't need to lose weight want to get thinner for cosmetic reasons. We understand that in some ways your weight is different from, for example, your cholesterol level or your blood pressure, because you can't see what these are by looking at someone. Many patients have had health care providers who approached their weight in a less-than-sensitive or helpful manner. Some patients may have had health care encounters in which they felt blamed, but not helped. Successful weight management is a long-term challenge.


text: At Wednesday 26/7/2006 18:57, KJZZ Webmaster wrote: >And you were right! This is not seen as as a valid dictionary (nor is it >seen as a string): > >stuff = container.externalmethod(feedurl=feedurl) >test = same_type(stuff, {}) >print test >return printed > >returns "0" > >However, interestingly enough, if I copy and paste the all the text that >is returned by the external method into the script, I am able to confirm >that it is a dictionary: > >stuff= {'lastbuilddate': u'Mon, 24 Jul 2006 12:06:18 EDT', >u'subtitle': 'U.S.', >u'generator': 'NPR/RSS Generator 2.0 etc...'} In this case you are using the Python syntax to create a dictionary, so it's not a surprise when it *is* a dictionary... Are you sure that your external method returns this *text*? It seems that you are looking at the string representation of some dictionary-like object. You can convert any dictionary-like object into a true dictionary using the builtin function dict: d = dict(an_object_that_acts_like_a_dictionary) Gabriel Genellina Softlab SRL __________________________________________________ Preguntá. Respondé. Descubrí. Todo lo que querías saber, y lo que ni imaginabas, está en Yahoo! Respuestas (Beta). ¡Probalo ya! http://www.yahoo.com.ar/respuestas

subset: commoncrawl


text:
Free Obtainable ranks!
[Owner] Anima a posted Sun at 21:51
Free autorank ranks have now been released!
Currently obtainable ranks are as follows:
Guest: 0 hours of playtime
2 Set homes
1 Player Vault
Member: 1 hour of playtime
3 Set homes
Access to Quarry world
Able to buy & sell from Chest Shops
2 Player Vaults
Active: 24 hours of playtime
3 Set homes
Star trail (/trails)
3 Player Vaults
..... Read more here!


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Football Card Sets
Browse our database of football card sets which features set checklists, product highlights, reviews and football card price comparisons.
- 1950-1959 Football Cards
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- 1990-1999 Football Cards
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2018 Panini Flawless Football Cards
The cream of the NFL collecting crop, 2018 Panini Flawless Football is again a super-premium set with six autographs, two memorabilia cards and two jewel cards per box.
2019 Sage Hit Premier Draft High Series Football Cards
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2019 Leaf Metal All-American Bowl Football Cards
Hunt for the next big gridiron star in 2019 Leaf Metal All-American Bowl Football. Hobby boxes have 8 prospect autographs and the new Jumbo format contains 12 signatures.
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text:
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nice game love it <3
Larry And The Gnomes is Absolutely Freakin' Epic!
I enjoy it a lot!!
This is the best game I have played and! :D
wow! its an awesome game its really imprsive and interesting i like it .... 5 stars!
ive dedicated more than five hours
but..... uhm can you like make a new level,
after youve beaten the king then you have to face
the kings right hand man,... any way good game


text:
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Rb antibodyCat No. GTX100545
Host : Rabbit
Clonality: Polyclonal
Application: WB, ICC/IF, IHC-P, IP
Reactivity: Hu
Specificity/Sensitivity: IP/MS validation was supported by references (PMID:30377374)
Package : 25μl, 100μl
images (5)


text:
New Zealand's greenhouse gas emissions rose by 2.2 per cent in 2017.
According to the annual Greenhouse Gas Inventory, emissions increased by 23.1 per cent between 1990 and 2017. This increase was largely driven by increases in road transport emission and fossil fuel-generated electricity production.
Key findings were:
- New Zealand's gross greenhouse gas emissions in 2017 were 80.9 million tonnes of carbon dioxide equivalent (Mt CO2-e). Compared to 1990, this is a 23.1 per cent increase in emissions.


text:
18 Years
Since We Started
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Cities with Students
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...I was studying Electrical Engineering for two years at Tufts University before I decided to take a leap and follow my passion of music. It has been an incredible journey ever since! ... Read More
...After graduating I gave lessons through music stores, skype and in my own home studio. Teaching has always come naturally to me because I genuinely love it. ... Read More
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18 Years
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It is beneficial for young students to start off by playing on a half size or three-quarter size acoustic guitar. Older students who can manage to hold their guitar comfortably may wish to use an electric guitar. A brand new student model guitar can be purchased for between $150 - $200. Amplification and guitar cables will need to be bought at additional costs for those wanting to play electric guitar. Students who enjoy and like playing their instrument will develop faster, so it is important to try and buy high quality instruments as these are typically easier to play.
Students can start taking their lessons as young as 6 years old with a half size classical guitar (with nylon strings) by playing simple melodies on the top strings. Every child learns and develops at their own pace, but by age 7-8, students will be forming and playing various guitar chords and learning simple songs that they can sing along to. Older students will graduate to being able to comfortably handle a full size guitar around the ages of 10-12, which is when many students become more interested in learning rock guitar and want to get an electric model.
The most important thing students learn is how to have fun when they are playing the guitar! It can be a challenge to master the basics, and it can take a lot of practice but with the proper teacher, students can be playing their favorite songs without too much trouble. Topics covered during guitar lessons include: learning notes, open chords, barre chords, finger picking, sight reading techniques, music theory as well as how to strum and pluck with the fingers.
Select all the days/times the student would be available to start lessons. Selecting "3pm - 7pm" means the student can start as early as 3pm or start as late as 7pm. It is important that you select as many days and the widest window of start times for each day as possible. That will help us make a match with one of our teachers.Ok
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text:
Create php donation formJobs
I have a Contact Form 7 plugin running here: [log ind for at se URL] and here [log ind for at se URL] But the forms are not sending e-mails upon form submit. I need help to fix that.
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fix problem php form sending emails.
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Need to build a Contact Form with 5 fields (Name, Mobile, Email, Subject, Description) well defined subject (in the form of drop down box) to be used in different places on Odoo 12 website pages. Also want Google ReCaptcha for my Odoo 12 Website.
Project Name : Additional "3d model project section" to my main application Programme : Visual studio 2017, C# WinForms Project Description : I have on going project about engineering calculations. In my current project, I read input (*.txt) files and make some engineering calculations background. I would like to add a 3D view section in my project to visualization. - showing 3d...
We have a two-page assessment form that needs to be designed into an editable pdf file. The form should have three colors and designed in a modern and upbeat way. I do not want the same thing back that I created. Here is an example of how I would like it to look. Must be done in an hour.
To create purchase order form for clients. Where they can sign and return to me .
Hi I am looking for a custom page creation in Wordpress, it will be a donation page on a website already launched, we just want you to design one page, similar to current design and upload the page on our server. 1. Wireframe for that page. 2. Design for that page 3. Development for that page. Let me know your cost with your previous work which
Please see the attached files. The form from [log ind for at se URL] currently captures the data the user inputs to an external source (campaigner), which is correct. However, when the form is submitted you are forwarded to an external page. I would like when the form is submitted to go to the [log ind for at se URL] page but keep the data that's captured. I'd also ...
I..."Florida Fertility Law" and instead of "The Law Office of Amy H. Eichman" it will be "The Law Office of Amy H. Cohen". I practice Fertility Law which is surrogacy, egg donation and adoption. Basically anything to do with creating a family and babies. I would like to keep same color scheme. Need simple, modern and professional.
We have a one page assessment form that needs to be designed into an editable pdf file.
I'm looking to add a pledge (list of names), calendar with submission form, public blog submission form, etc. to an existing Wordpress site (porting it over from [log ind for at se URL] to full Wordpress site). We need custom fields added so anyone can submit a blog post. We need two different types of "posts" so Advanced Custom Fields should be used. Submissions
I need a logo designed.
When putting in the shortcode into my website the Form is not appearing - need help
I'm trying to get a form online. I have attached the form. I need someone to php code the following: data validation for data type, size post data to sql database verify data has been posted to database the whole thing must be in one .php file. no pointers to outside servers.
my name is James, from Nairobi kenya. am intending to start a donation site with a cryptocurrency platform to aid global donation. this shall be on a decentralized system. so am now looking out for IT persons (blockchain experienced programmers to aid in the project development)
Need a website made that has these following features: -A home page with donation button (just liink it with paypal makes it easier) -create account page (they will be asked recruitment questions similar to the feedback page syntax) asked for email and pass like usual, then thier account will be under review and they will be told, infromation goes
need help with edit a form using autocomplete
...with donation button -create account page (they will be asked recruitment questions similar to the feedback page syntax) asked for email and pass like usual, then thier account will be under review and they will be told, infromation goes to a private area for commander rank and first sergeant rank to see, they can accept or deny users. -Donation page
I need someone to create a code for a similar contact form / survey as the one on the following page: [log ind for at se URL] that i may use on my site
I have a form that I need made beautifully Mobile Responsive. Need this done NOW. It's made with Gravity Forms but has a lot of CSS Changes.
Simple ionic form with 4-5 fields. Form post to node js express service. Not more than 1 day job .. if works out well I can award some more work related. Thanks
FOLDING A FORM PANEL WHEN PRESSED button SAPUI5.... Please help
My application is running with Laravel 5.4. I need a very simple feedback form which will have 4 questions. See below the tasks to be done. 1) Feedback Form: Ask following questions on feedback form a) Overall condition/ appearance of property - 1-10 (1 lowest – 10 best) b) Cleanliness of property - 1-10 (1 lowest – 10 best) c) How satisfied have
...like to create a Front End Form which will store (or) update new (or) existing user data to a Google Sheet. To avoid unwanted access by others a initial authentication of Student ID via OTP (if existing user) (or) ask for mobile number & authenticate user via OTP before proceeding to Google Form. Freelancer is expected to provide a intuitive Form Design
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Start taking classes at Spa Utopia and other studios!How it works
Spa Utopia
Start taking classes at Spa Utopia and other studios!How it works
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About this studio
Spa Utopa by Lucinda specializes in deep tissue massage, raindrop therapy and hot stone massage. She's dedicated to providing you with the best massage experience. All massage services include the BioMat to improve healing, relaxation, and detoxification. Aromatherapy can also be added for additional wellness benefits. Spa Utopia is a premier ClassPass Wellness venue. See their class descriptions for more information on the services they provide. Gratuity is not included in the cost of your reservation. Please remember to tip based on the full amount of the service reserved.roundrockbestmassage.com+1 605 215 1171
How to prepare
Spa Utopia by Lucinda Larson is located inside of A Zany Do Salon and Spa you can check in with the receptionist up front. Be sure to drink at least a liter of water before you come it will make your massage that much more enjoyable and your muscles pliable. Please arrive at least 15 minutes in advance of your appointment in order to get settled into the space and complete any necessary paperwork at the front desk. Please also note that you are reserving a specific appointment slot with an assigned practitioner at Spa Utopia, so if you need to cancel your reservation, please do so as early in advance as possible!
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Start taking classes at Spa Utopia and other studios!
What is ClassPass?
ClassPass is a new kind of gym membership that grants you access to thousands of different classes at studios and gyms in your city and around the world.
Price of membership depends on your plan type and city, and you can book and explore classes ranging from yoga to barre to cycling to martial arts – the options are truly endless!
The number of classes you can take and the number of times you can visit a studio per month depends on which plan you're on. You can figure out which plan you're on by going to your Account Settings and looking under 'Your current plan.' With hundreds of studios in our ever-growing network, you're bound to always find a new class to enjoy. When your cycle renews, you can go back and revisit those favorites yet again!


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Classroom Educator Open House
Wednesday, May 8, 3:30 - 6pm
Explore the Aquarium at this after-hours event sponsored by Ohio Lottery and learn about the standards-based classroom program offerings available to schools. Participate in our Classroom Educator Bingo Challenge and be entered into the prize drawing for ocean storybooks. Light refreshments available.
Pre-registered Classroom Educator* FREE
Additional Adult Guest $14.95
Additional Child (2-12) Guest $8.95
*Pre-registration required. Must present school ID.
*One (1) guest admitted free.


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Science & Health
Study Debunks Claim That Traffic Deaths Increase On The 4/20 Marijuana Holiday
Concerns about higher rates of impaired driving on the unofficial marijuana holiday 4/20 seem to be overblown, according to a new study accepted for publication in the journal Injury Prevention.
Some prior research has indicated that traffic fatalities spike on April 20—by as much as 12 percent—but the data supporting that claim has been limited in scope, the authors of the new paper said. So instead of singularly focusing on arbitrarily chosen control days one week before and after the daylong cannabis celebration for comparison, this latest study broadens the data pool.
Researchers at McGill University conducted three separate analyses. One compared traffic fatalities on 4/20 to control days one week before and after the holiday—the same data set used in prior research on the subject. Another considered both the one-week-apart control days as well as control days two weeks before and after the holiday. The last compared 4/20 traffic fatalities to the all the rest of the days in the year.
Then they took it another step, conducting the same analysis on five other major holidays.
"We found little evidence that the number of drivers involved in fatal traffic crashes are elevated on April 20 relative to any control period," the researchers said. "This is not because daily crash rates are too noisy to detect any signal. On the contrary, we find important, systematic, and meaningful variation in the daily number of drivers involved in fatal traffic crashes across the period from 1975 to 2016."
Traffic fatalities did seem to increase somewhat on 4/20 when looking at data from 1992 to 2016 and only comparing it to one-week control days, but "the magnitude of the estimate is consistent with the bulk of daily variations for many other days."
There were significantly more traffic crash fatalities on the 4th of July and the days before Labor Day and Thanksgiving. Interestingly, the analysis also showed that "systematically fewer drivers" were involved in fatal traffic accidents on Christmas and New Year's Day.
Over the years, the number of traffic fatalities on April 20 has remained relatively constant, which runs counter to expectations because if "recent celebrations of 4/20 were generating excess fatal crashes, we would expect to see a greater excess in recent years," the researchers wrote.
"We conclude that there is limited evidence of any population-wide effects of the annual cannabis holiday on fatal traffic crashes."
"The policy landscape for addressing marijuana-impaired driving is rapidly changing, and efforts to combat drugged driving are likely to require new initiatives," they continued. "Given the considerable resources already devoted to heightened enforcement campaigns to reduce the impact of impaired driving, there does not seem to be sufficient evidence for including 4/20 among 'risky' days."
Marijuana Legalization Means Safer Borders And Less Smuggling, Study Shows
Photo courtesy of Brian Shamblen.
Science & Health
Dogs Treated With Cannabis Oil Experience Less Frequent Seizures, Study Finds
Dogs with epilepsy experience considerably fewer seizures when treated with CBD oil, a new study published in the journal Pet Behaviour Science found.
The small study—which followed three dogs receiving hemp-derived CBD treatment over the course of two months, indicates that dogs respond to the cannabis compound in a way that's similar to humans.
The dogs ranged in age and breed. One was a three-year-old Labrador Retriever that suffered seizures spaced out one month apart on average, another was an 11-year-old Papillon that experienced seizures every two to three months and the last was a 10-year-old Chihuahua that has infrequent seizures about twice a year.
For the experiment, each dog was treated with CBD twice a day on an empty stomach. The findings are based on reports from the owners, two out of three of whom said the treatment improved their dog's condition. The Papillon's owner said the dog's condition was unchanged.
"The owner [of the Labrador Retriever] reported that the dog slept longer and barked less in the daytime, even when other dogs were excited, during the first two weeks than in the preceding weeks," the study authors wrote. "Overall, the owner felt that the dog showed improvement."
"The owner [of the Chihuahua] felt that seizure-like behavior during the attacks had decreased slightly with treatment," they wrote. "The owner also reported that the dog showed less aggression toward familiar people, such as the owner's children."
While the sample size of the study is particularly small, making it difficult to draw broad conclusions, the researchers said "seizure frequency improved considerably and owners reported a positive impression" of the CBD treatment.
It's not clear if the same biochemical mechanisms that make CBD an effective treatment for epilepsy in humans produced the effects in the dogs. It's possible that, because seizures can be triggered by anxiety, the same "anxiolytic effect may attenuate the symptoms of epilepsy in dogs as well as humans."
"Further research is needed for better understanding the neurobiological mechanisms of CBD treatment," the researchers wrote.
Last year, a separate study determined that CBD can alleviate the symptoms of osteoarthritis in dogs.
Photo courtesy of Pexels.
Science & Health
Study Finds Marijuana Motivates People To Exercise, Smashing Lazy Stoner Stereotype
Most people who use marijuana report that consuming before or after exercising improves the experience and aids in recovery, according to a new study. And those who do use cannabis to elevate their workout tend to get a healthier amount of exercise.
Researchers at the University of Colorado surveyed more than 600 marijuana consumers in states where it is legal to assess how people use cannabis in relation to exercise. Their results, published this month in the journal Frontiers in Public Health, poke yet another hole in the lazy, couch-locked stoner stereotype.
Almost 500 participants said they endorse using marijuana one hour before, or up to four hours after, exercising. And based on data from the questionnaire, those who did use cannabis in that timeframe worked out longer than consumers who didn't pair the activities. Specifically, those who engaged in co-use worked out an average of 43 minutes longer for aerobic exercise and 30 minutes longer for anaerobic exercise.
What's behind the trend?
There are a few known barriers to exercise that researchers have identified: a lack of motivation, difficult recovery after working out and low enjoyment of the activity. Cannabis seems to help lift those barriers for some individuals.
Seventy percent of respondents said they agree or strongly agree that "cannabis increases enjoyment of exercise," 78 percent said that marijuana "enhances recovery from exercise" and just over 50 percent said that it "increases motivation."
"To our knowledge, this is the first study to survey attitudes and behavior regarding the use of cannabis before and after exercise, and to examine differences between cannabis users who engage in co-use, compared to those who do not," the study authors wrote. "Given both the spreading legalization of cannabis and the low rates of physical activity in the US, it behooves public health officials to understand the potential effects—both beneficial and harmful—of cannabis use on exercise behaviors."
While it might seem counterintuitive given how cannabis consumers have typically been portrayed in media, there's a growing body of research showing that many marijuana enthusiasts engage in active lifestyles and that cannabis is associated with positive health outcomes. For example, another recent study found that people who use marijuana are less likely to be obese compared to non-users.
Marijuana Consumers Gain Less Weight Than Non-Users, Study Confirms
Photo courtesy of Brian Shamblen.
Another Federal Agency Wants You To Stop Calling About A Marijuana-Related Job
Six days after posting a notice that calls for a contractor to prepare and distribute research drug products like marijuana cigarettes, a federal agency posted an update, emphasizing that private citizens are not being encouraged to apply for a casual joint-rolling job.
Why? Well, it might have something to do with various viral articles reporting on the opening—and readers who then volunteer for the role.
On Monday, the National Institute on Drug Abuse (NIDA) added an unambiguous message at the top of the notice: "THE FOLLOWING IS A PRE-SOLICITATION NOTICE and is NOT ADVERTISEMENT FOR EMPLOYMENT."
The situation seems similar to another recent example that prompted the Houston division of the Drug Enforcement Administration (DEA) to ask private citizens to stop calling about a contractor opening to incinerate thousands of pounds of cannabis per hour.
The division wrote last month that "misleading articles" about the position "resulted in an influx of calls from citizens."
Several recent misleading articles alleging #DEAHouston is looking for Houstonians to burn Marijuana have resulted in an influx of calls from citizens. This solicitation was targeted for a large scale licensed vendor, not private citizens. https://t.co/GSygqBBWKB
— DEAHouston (@DEAHOUSTONDiv) March 29, 2019
"This solicitation was targeted for a large scale licensed vendor, not private citizens," they wrote.
But according to NIDA, their problem isn't quite as severe. In an email to Marijuana Moment, a representative of the agency said it has "only received a few public inquiries." The spokesperson did not respond to a follow up question about the reasoning behind the update.
For serious candidates, the position isn't as simple as rolling a massive amount of joints. The contractor must have "the capability to analyze and characterize various drugs of abuse including cannabinoids and other research chemicals" and also "acquire, develop, and produce marijuana and nicotine research cigarettes of varying strengths and specifications."
NIDA posted several cannabis-related contract notices last year, including for professional joint rollers and bulk marijuana manufacturers.
The DEA Wants You To Stop Calling Them About Getting Paid To Burn Marijuana
Photo courtesy of Philip Steffan.


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Search results for: Human RELM beta RELM-β
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TGF-β1-induced SMAD2/3/4 activation promotes RELM-β transcription to modulate the endothelium-mesenchymal transition in human endothelial cells.Endothelial-to-mesenchymal transition (EndMT), which is characterized by increased proliferation, migration and invasion of endothelial cells, increased expression of mesenchymal markers and reduced expression of endothelial markers, has been reported to be closely related to the pathogenesis of several diseases, including pulmonary fibrosis. Resistin-like molecule-β (RELM-β), also known as "found in inflammatory zone 2″ (FIIZ2), plays an essential role in airway remodeling and pulmonary fibrosis; however, its role and mechanism in EndMT remain unclear. Herein, we used TGF-β1-induced EndMT cell model in human umbilical vein endothelial cells (HUVECs) and human primary pulmonary artery endothelial cells (HPAECs) to investigate the function and mechanism of RELM-β in TGF-β1-induced EndMT in endothelial cell lines. We found that TGF-β1 stimulation significantly upregulated RELM-β expression; RELM-β knockdown could attenuate TGF-β1-induced cell proliferation and migration of endothelial cell lines and changes in protein levels of EndMT markers. SB432542, an inhibitor of SMADs, could partially reverse TGF-β1-induced RELM-β expression, endothelial cell migration and changes in EndMT marker protein levels. SMADs complex exerted its effects through SMAD2/3/4 complex mediating RELM-β transcription. In conclusion, TGF-β1 induces RELM-β transcription to promote EndMT in HUVECs and HPAECs through activation of SMAD2/3/4; blocking SMADs-mediated RELM-β transcription might ameliorate TGF-β1-induced EndMT in endothelial cells.
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Here, there and everywhere: Resistin-like molecules in infection, inflammation, and metabolic disorders.The Resistin-Like Molecules (RELM) α, β, and γ and their namesake, resistin, share structural and sequence homology but exhibit significant diversity in expression and function within their mammalian host. RELM proteins are expressed in a wide range of diseases, such as: microbial infections (eg. bacterial and helminth), inflammatory diseases (eg. asthma, fibrosis) and metabolic disorders (eg. diabetes). While the expression pattern and molecular regulation of RELM proteins are well characterized, much controversy remains over their proposed functions, with evidence of host-protective and pathogenic roles. Moreover, the receptors for RELM proteins are unclear, although three receptors for resistin, decorin, adenylyl cyclase-associated protein 1 (CAP1), and Toll-like Receptor 4 (TLR4) have recently been proposed. In this review, we will first summarize the molecular regulation of the RELM gene family, including transcription regulation and tissue expression in humans and mouse disease models. Second, we will outline the function and receptor-mediated signaling associated with RELM proteins. Finally, we will discuss recent studies suggesting that, despite early misconceptions that these proteins are pathogenic, RELM proteins have a more nuanced and potentially beneficial role for the host in certain disease settings.
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Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium.The mammalian intestine is colonized by trillions of bacteria that perform essential metabolic functions for their hosts. The mutualistic nature of this relationship depends on maintaining spatial segregation between these bacteria and the intestinal epithelial surface. This segregation is achieved in part by the presence of a dense mucus layer at the epithelial surface and by the production of antimicrobial proteins that are secreted by epithelial cells into the mucus layer. Here, we show that resistin-like molecule β (RELMβ) is a bactericidal protein that limits contact between Gram-negative bacteria and the colonic epithelial surface. Mouse and human RELMβ selectively killed Gram-negative bacteria by forming size-selective pores that permeabilized bacterial membranes. In mice lacking RELMβ, Proteobacteria were present in the inner mucus layer and invaded mucosal tissues. Another RELM family member, human resistin, was also bactericidal, suggesting that bactericidal activity is a conserved function of the RELM family. Our findings thus identify the RELM family as a unique family of bactericidal proteins and show that RELMβ promotes host-bacterial mutualism by regulating the spatial segregation between the microbiota and the intestinal epithelium.
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Resistin-Like Molecule Beta (RELM-β) Regulates Proliferation of Human Diabetic Nephropathy Mesangial Cells via Mitogen-Activated Protein Kinases (MAPK) Signaling Pathway.BACKGROUND Resistin-like molecule beta (RELM-β) has been reported to be associated with diabetic nephropathy (DN). However, the role of RELM-β in DN is poorly understood. This study was conducted to delineate the underlying mechanisms of action and to investigate the role of RELM-β in the primitive development of DN via MAPK signaling pathways. MATERIAL AND METHODS Lentivirus-mediated vectors and RNAi technology were used to establish the model of RELM-β up-regulated and down-regulated expression in human mesangial cells (HMCs). The proliferation of HMCs was detected through CCK-8 method. The cell cycle and cell proliferation of HMCs was detected through flow cytometry. The MAPKs pathway protein activity was detected through Western blotting. RESULTS The HMCs with up-regulated and down-regulated expression of RELM-β increased or decreased significantly at 2-3 days. The HMCs with high glucose intervention reversed the proliferation inhibition. The HMCs with exogenous glucose or RELM-β protein intervention partially reversed the cell cycle inhibition. Among the MAPKs pathway, the phosphorylation activity of p38MAPK and JNK increased or decreased and ERK1/2 did not change in the overexpression or inhibition of RELM-β. The p38 MAPK pathway inhibitor SB202190 significantly inhibited the proliferation of HMCs caused by overexpression of RELM-β. Up-regulated expression of RELM-b induced the phosphorylation of p38 MAPK, JNK in HMCs and promoted HMCs proliferation and participated in early DN through the MAPKs pathway. CONCLUSIONS The results provide evidence that RELM-b is a potential molecular target for the treatment of DN.
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Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.Nematode infections, in particular gastrointestinal nematodes, are widespread and co-infections with other parasites and pathogens are frequently encountered in humans and animals. To decipher the immunological effects of a widespread protozoan infection on the anti-helminth immune response we studied a co-infection with the enteric nematode in mice previously infected with . Protective immune responses against nematodes are dependent on parasite-specific Th2 responses associated with IL-4, IL-5, IL-13, IgE, and IgG1 antibodies. In contrast, infection elicits a strong and protective Th1 immune response characterized by IFN-γ, IL-12, and IgG2a antibodies. Co-infected animals displayed significantly higher worm fecundity although worm burden remained unchanged. In line with this, the Th2 response to in co-infected animals showed a profound reduction of IL-4, IL-5, IL-13, and GATA-3 expressing T cells. Co-infection also resulted in the lack of eosinophilia and reduced expression of the Th2 effector molecule RELM-β in intestinal tissue. In contrast, the Th1 response to the protozoan parasite was not diminished and parasitemia of was unaffected by concurrent helminth infection. Importantly, specific restimulation of splenocytes revealed -reactive CD4 T cells that produce a significant amount of IFN-γ in co-infected animals. This was not observed in animals infected with the nematode alone. Increased levels of -specific IgG2a antibodies in co-infected mice mirrored this finding. This study suggests that polarization rather than priming of naive CD4 T cells is disturbed in mice previously infected with . In conclusion, a previous infection limits a helminth-specific Th2 immune response while promoting a shift toward a Th1-type immune response.
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RELM-β promotes human pulmonary artery smooth muscle cell proliferation via FAK-stimulated surviving.Resistin-like molecule-β (RELM-β), focal adhesion kinase (FAK), and survivin may be involved in the proliferation of cultured human pulmonary artery smooth muscle cells (HPAMSCs), which is involved in pulmonary hypertension. HPAMSCs were treated with human recombinant RELM-β (rhRELM-β). siRNAs against FAK and survivin were transfected into cultured HPASMCs. Expression of FAK and survivin were examined by RT-PCR and western blot. Immunofluorescence was used to localize FAK. Flow cytometry was used to examine cell cycle distribution and cell death. Compared to the control group, all rhRELM-β-treated groups demonstrated significant increases in the expression of FAK and survivin (P<0.05). rhRELM-β significantly increased the proportion of HPASMCs in the S phase and decreased the proportion in G0/G1. FAK siRNA down-regulated survivin expression while survivin siRNA did not affect FAK expression. FAK siRNA effectively inhibited FAK and survivin expression in RELM-β-treated HPASMCs and partially suppressed cell proliferation. RELM-β promoted HPASMC proliferation and upregulated FAK and survivin expression. In conclusion, results suggested that FAK is upstream of survivin in the signaling pathway mediating cell proliferation. FAK seems to be important in RELM-β-induced HPASMC proliferation, partially by upregulating survivin expression.
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The goblet cell-derived mediator RELM-β drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis.Intestinal goblet cells are potentially key players in controlling susceptibility to ulcerative colitis (UC). Although impaired mucin (Muc2) production by goblet cells increases microbial stimulation of the colonic mucosa, goblet cells secrete other mediators that may influence or promote UC development. Correspondingly, Muc2-deficient ((-/-)) mice develop spontaneous colitis, concurrent with the dramatic upregulation of the goblet cell mediator, resistin-like molecule-beta (RELM-β). Testing RELM-β's role, we generated Muc2(-/-)/Retnlb(-/-) mice, finding that RELM-β deficiency significantly attenuated colitis development and symptoms compared with Muc2(-/-) mice. RELM-β expression in Muc2(-/-) mice strongly induced the production/secretion of the antimicrobial lectin RegIIIβ, that exerted its microbicidal effect predominantly on Gram-positive Lactobacillus species. Compared with Muc2(-/-)/Retnlb(-/-) mice, this worsened intestinal microbial dysbiosis with a selective loss of colonic Lactobacilli spp. in Muc2(-/-) mice. Orally replenishing Muc2(-/-) mice with murine Lactobacillus spp., but not with a probiotic formulation containing several human Lactobacillus spp. (VSL#3), ameliorated their spontaneous colitis in concert with increased production of short-chain fatty acids. These studies demonstrate that the goblet cell mediator RELM-β drives colitis in Muc2(-/-) mice by depleting protective commensal microbes. The ability of selective commensal microbial replacement to ameliorate colitis suggests that personalized bacterial therapy may prove beneficial for treatment of UC.
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Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance.Nematode infection upregulates interleukin-4 (IL-4) and IL-13 and induces STAT6-dependent changes in gut function that promote worm clearance. IL-4 and IL-13 activate the type 2 IL-4 receptor (IL-4R), which contains the IL-13Rα1 and IL-4Rα chains. We used mice deficient in IL-13Rα1 (IL-13Rα1(-/-)) to examine the contribution of IL-13 acting at the type 2 IL-4R to immune and functional responses to primary (Hb1) and secondary (Hb2) infections with the gastrointestinal nematode parasite Heligmosomoides bakeri There were differences between strains in the IL-4 and IL-13 expression responses to Hb1 but not Hb2 infection. Following Hb2 infection, deficient mice had impaired worm expulsion and higher worm fecundity despite normal production of Th2-derived cytokines. The upregulation of IL-25 and IL-13Rα2 in Hb1- and Hb2-infected wild-type (WT) mice was absent in IL-13Rα1(-/-)mice. Goblet cell numbers and resistin-like molecule beta (RELM-β) expression were attenuated significantly in IL-13Rα1(-/-)mice following Hb2 infections. IL-13Rα1 contributes to the development of alternatively activated macrophages, but the type 1 IL-4R is also important. Hb1 infection had no effects on smooth muscle function or epithelial permeability in either strain, while the enhanced mucosal permeability and changes in smooth muscle function and morphology observed in response to Hb2 infection in WT mice were absent in IL-13Rα1(-/-)mice. Notably, the contribution of claudin-2, which has been linked to IL-13, does not mediate the increased mucosal permeability following Hb2 infection. These results show that activation of IL-13Rα1 is critical for key aspects of the immune and functional responses to Hb2 infection that facilitate expulsion.
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Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.Activation of the immune response during injury is a critical early event that determines whether the outcome of tissue restoration is regeneration or replacement of the damaged tissue with a scar. The mechanisms by which immune signals control these fundamentally different regenerative pathways are largely unknown. We have demonstrated that, during skin repair in mice, interleukin-4 receptor α (IL-4Rα)-dependent macrophage activation controlled collagen fibril assembly and that this process was important for effective repair while having adverse pro-fibrotic effects. We identified Relm-α as one important player in the pathway from IL-4Rα signaling in macrophages to the induction of lysyl hydroxylase 2 (LH2), an enzyme that directs persistent pro-fibrotic collagen cross-links, in fibroblasts. Notably, Relm-β induced LH2 in human fibroblasts, and expression of both factors was increased in lipodermatosclerosis, a condition of excessive human skin fibrosis. Collectively, our findings provide mechanistic insights into the link between type 2 immunity and initiation of pro-fibrotic pathways.
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Goblet Cell Derived RELM-β Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation.Enterohemorrhagic Escherichia coli and related food and waterborne pathogens pose significant threats to human health. These attaching/effacing microbes infect the apical surface of intestinal epithelial cells (IEC), causing severe diarrheal disease. Colonizing the intestinal luminal surface helps segregate these microbes from most host inflammatory responses. Based on studies using Citrobacter rodentium, a related mouse pathogen, we speculate that hosts rely on immune-mediated changes in IEC, including goblet cells to defend against these pathogens. These changes include a CD4+ T cell-dependent increase in IEC proliferation to replace infected IEC, as well as altered production of the goblet cell-derived mucin Muc2. Another goblet cell mediator, REsistin-Like Molecule (RELM)-β is strongly induced within goblet cells during C. rodentium infection, and was detected in the stool as well as serum. Despite its dramatic induction, RELM-β's role in host defense is unclear. Thus, wildtype and RELM-β gene deficient mice (Retnlb-/-) were orally infected with C. rodentium. While their C. rodentium burdens were only modestly elevated, infected Retnlb-/- mice suffered increased mortality and mucosal ulceration due to deep pathogen penetration of colonic crypts. Immunostaining for Ki67 and BrDU revealed Retnlb-/- mice were significantly impaired in infection-induced IEC hyper-proliferation. Interestingly, exposure to RELM-β did not directly increase IEC proliferation, rather RELM-β acted as a CD4+ T cell chemoattractant. Correspondingly, Retnlb-/- mice showed impaired CD4+ T cell recruitment to their infected colons, along with reduced production of interleukin (IL)-22, a multifunctional cytokine that directly increased IEC proliferation. Enema delivery of RELM-β to Retnlb-/- mice restored CD4+ T cell recruitment, concurrently increasing IL-22 levels and IEC proliferation, while reducing mucosal pathology. These findings demonstrate that RELM-β and goblet cells play an unexpected, yet critical role in recruiting CD4+ T cells to the colon to protect against an enteric pathogen, in part via the induction of increased IEC proliferation.
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1.0MP 25fps Processor: Hi3518E Image Sensor:1/4" COMS OV9732 1280x720
1.3MP 25fps Processor: Hi3518E Image Sensor:1/3" COMS SC1135 1280x960
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TF card camera. Its purpose is to store video motion detection alarm.Its general in 15 senconds/video segments.Ordinary video 15 minutes at most/video segments.If you want to record a video all day .
Recommended to choose NVR storage.
This camera is a built-in TF card, you need to open the back cover of the camera before installing the TF card!!


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Cognitive Approach: IB Diploma Psychology Short Answer Questions SAQs
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This collection of exemplar essays provides examples of how to respond to short-answer questions for the IB Psychology Cognitive Approach topic.
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Cognitive Approach: IB Diploma Psychology Short Answer Questions SAQs
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- Explain one research method used to investigate cognitive processing.
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- Explain one bias in thinking and/or decision-making.
- Outline one ethical consideration with research into the reliability of cognitive processes, using one example of a relevant study.
- Describe one research method used to investigate emotion and cognition.
- Explain how emotion affects one cognitive process, using relevant research
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Haplotype caller for SNP calling from RNA seq data
Homa Member ✭
I have a general question. Why is it recommended to use single sample for SNP calling from RNA-seq data when using Haplotype caller? Isn't possible to provide all the samples together for the SNP calling purpose? Is it a rather technical aspect of Haplotype Caller or it helps to reduce errors?
Thanks a lot in advance for your help,