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IT suppliers
Video: challenges of strategic outsourcing
In this video, Computer Weekly's Cliff Saran speaks to Navin Anand, executive consultant at ImprovIT about where outsourcing is heading
Video review: HP Pavilion Chromebook
The Pavilion Chromebook is HP's cheapest full-sized laptop. Computer Weekly gives it a test drive
Video interview: Kim Stevenson, CIO, Intel
Kim Stevenson is the CIO of Intel, leads a team of over 6,000 IT staff globally and is responsible for the company-wide use of IT
Video review: Microsoft Surface Pro
Surface Pro is an important step for Microsoft as it continues along the path set by CEO Steve Balmer to offer both software and hardware
Video interview: Andy Harter, CEO, RealVNC
In this video, RealVNC CEO Andy Harter speaks to Computer Weekly about the company's remote access software
Interview with Professor Andy Hopper, Cambridge Computer Laboratory
Andy Hopper, head of the Computer Laboratory at Cambridge University, on how universities should fund start-ups and use intellectual property
Intel pushes business benefits of 4th generation ultrabooks
Given lacklustre PC sales, Intel is keen to push the merits of new ultrabooks as good for business
Video: TechTarget Purchasing Intentions survey on IT Security
In this video Computer Weekly's security editor, Warwick Ashford explains what is happening with mobile device management and data loss prevention.
Video: Smartphone biometrics
Computer Weekly speaks to three companies using biometrics for healthcare apps
Big data impact on storage infrastructure
Ovum senior analyst Tim Stammers discusses how storage systems cope with large data sets and real time data access
Video: Why IT departments are spending more on security
In this video, Forrester analyst Andrew Rose discusses how chief information security officers are spending their buidgets
Video interview: Fine-tuning decision-making
In this interview, Paul Michaels, CEO of busienss and technology consultancy ImprovIT, discusses a methodology for modelling decision-making
Video interview: Stephen Mann, Forrester, on IT asset management
In this video, Forrester analyst Stephen Mann discusses the benefits of strong IT asset management processes within IT departments
Video interview: Gartner chief of research, Chris Howard
In this video, Chris Howard, chief of research at Gartner, discusses why CIOs should look at cloud, mobile, big data and social computing
Video interview: Peter Sondergaard on lack of big data skills
In this video Gartner's head of research, Peter Sondergaard, speaks to Cliff Saran about the skills issue that will impact big data
Video: Forrester's John Rakowski discusses private clouds
In this interview Forrester analyst John Rakowski discusses how private clouds can be used in business
Acer launches Windows 8 multi-mode devices
Acer has introduced a family of tablet and notebook computers that offer touch, type and view modes of usage.
Video interview: Why develop for Windows 8?
In this interview, Anand Krishnan, director, developer & platform group, Microsoft UK speaks about Windows 8 development
Video: Melanie Fourie, Tiger Wheel & Tyre
Tiger Wheel & Tyre took the VMworld Europe 2012 User Award for best virtualisation and server consolidation project project
CW500: Mitchells & Butlers' COO Robin Young - IT in the boardroom
In this CW500 Club video, Mitchells & Butlers' COO Robin Young talks about how IT is perceived in the boardroom
Influential women in IT: Catherine Doran, Royal Mail
How to attract and retain women in IT is a key point of the debate around the gender divide in the profession. In this speech, Catherine Doran draws on her own recent history as a member of the e-Skills CIO board and CIO at Royal Mail Group, which is currently recruiting 100 people into IT.
Influential women in IT: Denise McDonagh, Home Office & G-Cloud Programme
From the standpoint of a long-serving public sector IT professional, Denise McDonagh looks at the challenges and opportunities for women seeking careers in IT delivery in government departments.
Influential women in IT: Pauline Neville-Jones—Former UK Government Cyber Security Chief
The lack of the fairer sex in the computing world is a matter of note without good justification. Baroness Pauline Neville-Jones asks, what are the reasons and what can and should we do about this?
Influential women in IT: Sue Black, The GoTo Foundation
In this talk, academic and campaigner Sue Black talks about how technology is important for everyone, not just "geeks". She also talks about her work at the GoTo Foundation, a new organisation set up to promote technology as a vital part of our society and our economy.


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Come and enjoy 2 hours of outstanding music asBeth Odets-Brown takes the stage at 2pm and Twostep Spiritweaver follows her to raise funds to put food on needy children's plates in the slums of Nakuru, Kenya - and lovely SMILES on their faces - and of course for your musical delight.
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Do you have more than cake and ice cream on the menu at your birthday party? Then you should totally pick up these bright polka dotted paper plates. At 9" square, these festive plates are perfect for holding sandwiches, dip, chips and that serving of cake and ice cream. How about pairing these plates with our Hip Hip Hooray cake plates, because after all, cake and ice cream are the stars of the show! These dinner-sized plates are ideal for holding all the yummy things that your guests desire!
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Giving Shenzhen A Second Chance en
nomadicnotes.com · nomadicnotes
Returning to Shenzhen six years after my first visit to find a completely different city than what I remember.
The Re-emergence Of Bangkok Chinatown – Get There Before The Metro Does
nomadicnotes.com · nomadicnotes
Chinatown in the old city area of Bangkok is starting to gentrify in anticipation of the Blue Line MRT metro extension.
Sihanoukville – The New Macau Of Southeast Asia
nomadicnotes.com · nomadicnotes
Sihanoukville on the coast of Cambodia is being transformed into a gambling hub, and has been called the New Macau of Southeast Asia.
The Legal Nomads Guide to Saigon Street Food : Legal Nomads en
legalnomads.com · nomadicnotes
A giant post on Saigon street food, gluten-free eating, and enjoying your meals in town.
Southeast Asia Current And Proposed Railways [2017] en
nomadicnotes.com · nomadicnotes
A detailed map of what Southeast Asia would look like if every proposed railway was built.
The Regeneration Of Kuala Lumpur Old City en
nomadicnotes.com · nomadicnotes
The redevelopment of the Chinatown/Heritage Quarter of Kuala Lumpur, including the River of Life Project, the new metro, and KL118.


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Fear has returned to France—and it has always been the Front National's best fuelby Christine Ockrent / December 4, 2015 / Leave a comment
People are buying flags. Young men are enlisting in the armed forces at an unprecedented rate. Fresh flowers are brought every day to the locations of the massacres, joining the piles of withered leaves covering bloodstains. Before it became too cold, people in the neighbourhood made it a point to have their drinks on café terraces. Soldiers and police in bulletproof vests are on patrol, weapons in sight. Paris has become less boisterous.
Since that frightful evening on 13th November, the French have shown resilience and a rare spirit of unity. President François Hollande's actions—extending the national state of emergency for three months and embarking on retaliatory strikes against Islamic State (IS) in Syria—have received massive support, with 91 per cent of the French approving of his response. His own popularity rating, which throughout his tenure has been lower than any of his predecessors, has risen by 10 percentage points, reaching 50 per cent, his best post election score.
Ten months after the Charlie Hebdo killings, the socialist President has emerged strongly from the latest bloodbath. Ever the tactician, he stunned Parliament on 16th November by calling for a change in the Constitution to give the police exceptional powers, switching overnight from an emotional response to a political one. His status has been enhanced by the performance of his two most able ministers: Bernard Cazeneuve, the Minister of the Interior, and Jean-Yves Le Drian, the Defence Minister. Whatever the failures in intelligence, their handling of the fallout from the attacks has won praise on all sides.
How will these dramatic events translate into political terms? The conservative opposition is in disarray. Its traditional monopoly over police and security issues has been swept away. The Republican leader Nicolas Sarkozy, normally boastful, has not performed well. Out of sync with the public mood, he first supported the Elysée's response only to criticise its shortcomings the next day and encourage his MPs to attack the government in Parliament. The official mourning period was still in effect and the scene, broadcast on national tele-vision, did not go down well. The confusion among Les Républicains heightened when Alain Juppé, Sarkozy's main rival for the party primaries due to take place in the autumn, expressed full support of Hollande's actions, calling for national unity rather than political bickering.
Read more:
Paris' Bataclan Generation: "This is our struggle, not yours"
It's time to learn the lesson of the Front National's success
The Paris attacks are a quantum leap in Islamic State's capabilities
On the left, the customary Socialist Party rattling over Prime Minister Manuel Valls's "liberal" economic policies has given way to subdued criticism of his overly martial stance and his alarmist warnings about the risk of biological and chemical attacks. Yet the party has no other choice but to tighten up the rank and file. And there are side benefits: the most blatant failures of the past three years have faded away for the moment—unemployment, growing in-equalities, the lack of structural reforms and even the deficit. On the extreme left, politicians and commentators hesitate to break with the message of national unity.
So far, the debate over the possible infringement of civil liberties by the state of emergency has not taken off. Official calls for restraint, for example, not to put photographs of the dead at the Bataclan concert hall on Twitter, have been quietly respected.
Among French intellectuals, even the most raucous proponents of freedom of speech have been content to write against the common enemy: terror. Only Michel Onfray, the self-promoted "philo-sopher of the people," broke ranks. "Right and left sowed war against political Islam, and now they are reaping it back," he wrote on Twitter. Onfray, who has called for negotiations with IS, was heavily criticised for his Tweet, which was used approvingly by IS on its own propaganda channels.
All this leaves the far right as the main political beneficiary. "See! All of the Front National's arguments are proven right!" was the message of party leader Marine le Pen with a half smile the day after the attacks. There was no need for her to shout and scream about the elites' incapacity to cope with the real issues. Islam, immigration, multiculturalism, open borders, Schengen, Europe—Le Pen's favourite targets are all represented, and her political harvest promises to be bountiful.
Three French voters out of 10 would now rally her arguments. The December elections could well bring Marine in the north and her niece Marion in the south at the helm of two of the biggest regions in the country. In time, the tune of national unity is bound to fade. The stock market has not been directly affected, but high street sales were down and department stores empty. Fear has returned—and it has always been the Front National's best fuel.


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Use the form on the right to contact us.
You can edit the text in this area, and change where the contact form on the right submits to, by entering edit mode using the modes on the bottom right.
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Barclays' Australian Casualties Included Three MDs
Three Sydney-based managing directors bore the brunt Barclays PLC's decision to lay off 15% of its investment banking division across Asia, people familiar with the matter told Deal Journal Australia.
They were Head of Distribution Lucio Febo, Head of Risk Solutions Group Peter Berckelman and Head of Power, Utilities and Infrastructure and Communications, Media and Technology Scott Jindrich. Mr. Jindrich also led coverage of Real Estate.
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Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Depression, MetS Linked in Older Latinos with Diabetes
Am J Geriatr Psychiatry; ePub 2017 Feb 23; Cardenas, et al
Depression is significantly linked to metabolic syndrome (MetS), and most notably dyslipidemia, in older Latinos with diabetes, a recent study found. 332 community-dwelling older (aged ≥60 years) Latinos with type 2 diabetes completed the 9-item Patient Health Questionnaire (PHQ-9) and received a health check-up assessing Body Mass Index (BMI), triglyceride and high-density lipoprotein (HDL) cholesterol levels, and blood pressure. Logistic regression analysis compared MetS rates of those meeting criteria for depression to those who did not. Secondary analyses examined the associations between depression and individual MetS components. All analyses controlled for demographic (eg, income, age) and other potential MetS risk factors (eg, smoking status, physical activity, and alcohol consumption). Researchers found:
- Depression was significantly associated with an increased risk of MetS, as well as clinically significant elevations in triglycerides and reduced (HDL) cholesterol.
- A significant association was not observed between depression and either BMI or hypertension.
Cardenas V, Mausbach BT, Sommerfeld D, et al. Depression is associated with increased risk for metabolic syndrome in Latinos with type 2 diabetes. [Published online ahead of print February 23, 2017]. Am J Geriatr Psychiatry. doi:10.1016/j.jagp.2017.02.017.
This Week's Must Reads
Family Involvement in Veterans with Schizophrenia, Psychiatr Rehabil J; ePub 2019 Mar 28; Cohen, et al
Cognitive Training Program in Schizophrenia, Schizophr Res; ePub 2019 Mar 28; Mahncke, et al
Continuous Exercise & CI in Schizophrenia, Front Psychiatry; ePub 2019 Mar 13; Herbsleb, et al
MHC Risk Variants in Cortical Thickness, Brain Behav; ePub 2019 Mar 28; Tao, et al
Disclosing the Diagnosis of Schizophrenia, Int J Soc Psychiatry; ePub 2019 Mar 27; Setti, et al
Must Reads in Depression
Early-Life Stress Linked with Cytomegalovirus in MDD , JAMA Psychiatry; ePub 2019 Mar 6; Ford, et al
Collaborative Intervention for Obesity, Depression , JAMA; 2019 Mar 5; Ma, Goldman Rosas, Lv, et al
Body Weight Predicts Risk for Depressive Symptoms , J Affect Disord; ePub 2019 Mar 5; Vittengl
Slow-Wave Activity and Mood Disturbance in MDD, Psychol Med; 2019 Mar; Goldschmied, et al


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Closed Consultations
Draft Local Plan October 2012 Closed
The draft Local Plan (previously called the 'Core Strategy') sets out the overall framework to guide future development throughout West Oxfordshire over the next 17 years. The plan has been updated to take account of previous consultation responses, changes to MOD housing requirements at Carterton, transport proposals at Witney and the Government's recent National Planning Policy Framework (NPPF).
Open from 07 Nov 2012 to 19 Dec 2012
West Oxfordshire Local Plan 2031 - PROPOSED MAIN MODIFICATIONS Closed
Open from 07 Nov 2016 to 25 Dec 2016
Article 4 Direction - Leafield Technical Centre Closed
Open from 19 May 2016 to 20 Jun 2016
Article 4 Direction - West Oxon Business Sites Closed
Consultation on the application of Article 4 Directions, to remove permitted development rights for the change of use from office buildings to residential use.
Open from 24 Mar 2016 to 05 May 2016
Immediate Article 4 Direction Closed
Open from 29 Feb 2016 to 31 Mar 2016
West Oxfordshire Design Guide Closed
Open from 14 Dec 2015 to 22 Jan 2016
Community Infrastructure Levy - Settlement Boundary Consultation Closed
Consultation on proposed settlement boundaries in West Oxfordshire, to define where different CIL charges for commercial development should apply.
Open from 20 Nov 2015 to 18 Dec 2015
West Oxfordshire Proposed Submission Local Plan 2011-2031 Closed
This consultation is being undertaken in accordance with Regulation 19 of The Town and Country Planning (Local Planning) (England) Regulations 2012
Open from 27 Mar 2015 to 08 May 2015
Statement of Community Involvement Update 2014 Closed
The SCI sets out the ways the local community can get involved in the future development of West Oxfordshire. The updated SCI takes account of changes to national policy, increased use of electronic communication including social media and the duty to co-operate. We would welcome your views on the SCI update before it is finalised and adopted later in the year.
Open from 08 Aug 2014 to 19 Sep 2014
West Oxfordshire Local Plan Housing Consultation Closed
The purpose of this consultation document is to set out the Council's response to the findings of the SHMA and other relevant evidence and explain how the Local Plan will be taken forward.
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Amy Ray performs her song, "More Pills" live at Variety Playhouse in Atlanta, GA.to celebrate the release of her new record, "Goodnight Tender." The
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Cool Kickstarter from some DungeonMorph Dice - [image: Cool Kickstarter from some DungeonMorph Dice] OK folks....here's the deal. Inkwell Ideas is running a Kickstarter for another round of DungeonMorph ...
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The Lily Journal
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In this post, you will hear Laura share her top three reasons brides book at our venue and how they directly reflect her purposeful vision she set for The Marmalade Lily Weddings experience.
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CTI BioPharma is a biopharmaceutical company whose mission is to acquire, develop and bring to market less toxic, more effective therapies to treat and cure cancer. Our therapeutic focus is on novel targeted therapies covering a spectrum of blood-related cancers. We see patients as people, looking at potential therapies from the patient's perspective to address both the clinical need and the impact treatment can have on a patient's life. We prioritize the patient experience and are committed to developing therapeutic options for people living with cancer who want a chance at a longer and better quality of life.0


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Highlight yourself for planning for a wedding reception or cocktail party? An evening dress is the proper selection for you when paired it with good footwear. Body shape is the foremost important element you wish to stay in mind before buying the most effective evening dress. To remain in the limelight of the party the color of the dress and therefore the matching accessories is the simplest decision before showing for the party.
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A teenager would spend most of the time planning for the abundant awaited Promenade party or evening party. They like to buy the best promenade dress that will fit the body form perfectly. Evening dresses created of shiny fabric will look enticing for you to stay in the spotlight of the party. Let's take a look at the simplest evening dress and therefore the matching footwear:


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Pennyworth Thrift Shop will be open for two more shopping days before shutting down in preparation for an eventual move to the basement of Grace House on the grounds of Grace Episcopal Church at 1607 Grace Church Rd.
The shop at 949 Bonifant St. will be open from 10 a.m. to 4 p.m. Saturday, Dec. 8 and again on Saturday, Dec. 15.
Everything in the store will be sold for $1 on those two days.
On the final day of shopping, patrons can enjoy snacks and sparkling beverages from 1-4 p.m.
The shop hopes to reopen in its new location in the spring, according to board member Grace Shirey.
Photo by Marsha Obusek courtesy Pennyworth Thrift Shop.
Follow Source of the Spring on Facebook, Twitter and Instagram. Sign up for our free Weekly Newsletter here. Learn how to submit events to our Community Events Calendar here. Please send tips and questions through our News Tips form, or email info [at] sourceofthespring.com. Learn how to support Source of the Spring here.
Mike Diegel
Latest posts by Mike Diegel (see all)
- Sligo Pit BBQ Opens at Sligo Creek Golf Course - April 22, 2019
- County Executive to Eliminate Jazz Festival, Consider Smaller Events - April 19, 2019
- GW Immediate & Primary Care Clinic to Close this Weekend - April 18, 2019


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A Virginia city's penalty of jail time for teenage trick-or-treaters has scared up some ridicule and a possible policy change.
There are no tricks when it comes to the weather this Halloween. In fact, fair skies and mild temperatures in the 60s will make for a real treat. Here's the forecast for your Halloween night.
Halloween is just around the corner, and so is your kids' large candy hauls. But with these tips from Sally Squires, writer of the Lean Plate Club, your kids' sugar high doesn't have to be the scariest thing this Halloween season.
Making a great costume can be time-consuming and expensive, but there are many get-ups that are easy to assemble and put together. For most of them, you probably already have the supplies you need to build them at home.
Homes participating in the Teal Pumpkin Project display a teal pumpkin and have nonfood treats such as glow sticks or small toys to hand out.
Recreating the District in video game form was no small task. Here's how the developers did it.


text: == Series Details == Series: series starting with [1/2] drm/i915/selftests: Fix up igt_reset_engine URL : https://patchwork.freedesktop.org/series/35537/ State : failure == Summary == Applying: drm/i915/selftests: Fix up igt_reset_engine Using index info to reconstruct a base tree... M drivers/gpu/drm/i915/selftests/intel_hangcheck.c Falling back to patching base and 3-way merge... Auto-merging drivers/gpu/drm/i915/selftests/intel_hangcheck.c CONFLICT (content): Merge conflict in drivers/gpu/drm/i915/selftests/intel_hangcheck.c Patch failed at 0001 drm/i915/selftests: Fix up igt_reset_engine The copy of the patch that failed is found in: .git/rebase-apply/patch When you have resolved this problem, run "git am --continue". If you prefer to skip this patch, run "git am --skip" instead. To restore the original branch and stop patching, run "git am --abort".


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This site requires at least 800 X 600 screen resolution for optimum viewing
Capital Computing is a thirty minute news program which was broadcast every Thursday on Radio 1RPH in Canberra - 1125 KHz on the AM band. The first program was broadcast on 18 April 1996 and the last program went to air on 28 May 1998. It was produced by volunteers from the PC Users Group of the ACT and featured news and views on the world of personal computing and communications.
This website will be maintained for archival interest until July 1998 and will then be removed. The picture on the right shows Mike Gellard, the program anchor in the centre, with Brian Williamson operating the reel-to-reel on Mike's left. Honey Nelson is sitting above Brian, Chris Arndt on the top right and Terry Bibo on the right hand side below Chris.
|Selected article transcripts
Archival material about Capital Computing and some information about Radio 1RPH.


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What's On
Tippett & Bourne + Isotach
Thursday 23 May 7.30pm
RNCM Theatre
Two of the greatest British jazz pianists meet across the generational divide in an exciting new collaboration.
Pursuing a long-standing respect for each other's music, Matthew Bourne and Keith Tippett take their relationship to the next stage and show their boundless creativity shares a common ground. Last autumn, during several days of musical exploration at Bristol's Colston Hall, Tippett and Bourne discovered a magical improvisatory connection – and a new duo was born.
Both are mesmerising performers, famous for their idiosyncrasy, virtuosity and non-conformity. Their collaboration is a gem of synergy that epitomises the energy and beauty of improvisers at the top of their game.
The evening opens with a string trio set performing new arrangements of the recent Isotach project, where Bourne is at his most spacious and contemplative.
manchester jazz festival in association with RNCM


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The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH
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Most solid human tumors exist in an acidic microenvironment, due in part to inefficient vasculature and a higher intrinsic rate of glycolysis. This leads to a tumor-selective pH gradient, which can be exploited therapeutically with antitumor agents such as the camptothecins (CPTs). Previous work in this laboratory has shown that camptothecin activity is enhanced 40- to 60-fold in monolayer cell culture by reducing the extracellular pH to 6.8. Three-dimensional histoculture has been shown to be a technique that allows human tumor tissue to grow in an in vivo-like way with maintenance of tissue histology and function and drug sensitivity for long periods of time.
In the current study, we utilized these features of histoculture to study new analogues of camptothecin that have superior pharmacological properties.
We evaluated six CPT analogues in histocultures of human brain, neuroblastoma, breast, colon, and prostate tumors. Fragments were exposed to 10,11-methylenedioxy-CPT (MDC), 7-chloromethyl-MDC, SN-38, topotecan (TPT), 9-amino-CPT, 10-amino-CPT, paclitaxel, 5-fluorouracil, 4-hydroperoxycyclophosphamide and doxorubicin, and antitumor activity was assessed. For in vivo tumor outgrowth studies, fragments were treated in parallel, implanted into nude mice, and monitored for development of tumors.
Against 15 of 16 tumor xenografts and all primary tumor samples tested, all compounds were cytotoxic at pH 7.4 (IC50 range 13–921 μM). MDC, SN-38, TPT, and 9-amino-CPT achieved an average 5-fold increase in activity (range 3–14) at pH 6.8, while 7-chloromethyl-MDC was enhanced 8-fold (range 6–14). The most potentiated analogue was 10-amino-CPT at 27-fold (range 17–49). In contrast, the other agents were active against one or more tumor types but were not enhanced by acidic pH. Importantly, the toxicity of MDC in histoculture of D54 glioma xenografts strongly correlated with the outgrowth of treated fragments subsequently implanted in vivo.
Evaluation of anticancer drug activity in native-state histoculture supports the concept that pH modulation may be an important approach to improve the selectivity and antitumor effectiveness of camptothecin-based chemotherapy.
KeywordsCamptothecin Histoculture pH modulation In vitro drug screening
This work is dedicated to the memory of Dr. Monroe E. Wall. The authors wish to acknowledge Alan Proia and Duke Surgical Pathology for invaluable assistance with procuring the primary human tissue samples and Stacey Snyder of Duke Radiation Oncology Department, Ray Liao and Dr. David Price of Duke Urology Department and Steve Keir of Duke Neurooncology Department for expert technical assistance and providing xenografts for histoculture experiments. This work was supported by NIH grant U01 CA68697-02.
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