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Annual Athletic Meet 2018-19Mar 02, 2019
The much-awaited Annual Athletic Meet of SFHS Middle School was held on Thursday, 28th February 2019, with great zeal, excitement and frolicsome atmosphere.The programme began with Shireen Ahluwalia taking the oath and the Principal, Mrs. Sangeeta Sekhon declaring the Meet open. Once the races began, the air was filled with boisterous cheering and tons of encouragement for the young athletes.The students of classes 5, 6, 7 and 8 participated in 80m Hurdles, 80m Sprint, 200m Sprint, 400m Sprint, and Shot Put.
The 4 X 100 m Inter House Relay brought the children totheir feet as they cheered to support their houses. Aether House won both theGirls and Boys Relay event in classes 7 and 8, while Terra House secured thefirst place in the Girls relay in classes 5 and 6, and Aether House won in theBoys Relay event in classes 5 and 6.
The Meet concluded with an Inter-House Tug of War event, whichwas held amidst soaring energy levels and an electric atmosphere all around.ElmaaHouse proved to be the strongest house in classes 5 and6, while Terra House won the Tug of War in classes 7 and 8.
The ecstatic winners were awarded with certificates fortheir breathtaking and astounding display in the various track and fieldevents.It was a perfect culmination for the session, which ended on a note ofhigh energy and excitement.


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It would be amazing if I could:
- overlay two charts, e.g. a stacked bar chart (of costs) and a line graph (of revenue)
- customize the colors for each section (not just with main colors but any hex color, e.g. different shades of same color)
I hope I am ignorant and these things are already possible; please let me know.
Thanks for building Coda!


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Bachelor of Kinesiology
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golf, CGA, carolinas, junior, equipment, sport, PGA, LPGA, association, magazine
Issue link: http://www.carolinasgolfmagazine.com/i/1094194
reland's northern neighbors in Scotland enjoy the
"Home of Golf" label, but Irish eyes may have smiled
upon the game's beginnings. According to some his-
torians, Irish monks crossing the North Channel of
the Irish sea brought with them to Scotland's Machrihanish
area a ball-and-stick sport similar to modern hurling. Legend
has it that the game evolved into something closer to today's
golf, and made its way up the Mull of Kintyre to Edinburgh
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country within the same trip.
Golf's spotlight is shining even brighter on Ireland this year, as Northern
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will host the event, marking the first time since the club hosted the 1951
Golf Digest considers Royal
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New Research In
Physical Sciences
Social Sciences
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PNAS Plus Significance Statements
Multifunctional, inexpensive, and reusable nanoparticle-printed biochip for cell manipulation and diagnosis
Rahim Esfandyarpour, Matthew J. DiDonato, Yuxin Yang, Naside Gozde Durmus, James S. Harris, and Ronald W. Davis
Point-of-care diagnostics in the developing world and resource-limited areas require numerous special design considerations to provide effective early detection of disease. Of particular need for these contexts are diagnostic technologies featuring low costs, ease of use, and broad applicability. Here we present a nanoparticle-inkjet-printable microfluidics-based platform that fulfills these criteria and that we expect to significantly reduce the footprint, complexity, and cost of clinical diagnostics. This reusable $0.01 platform is miniaturized to handle small sample volumes and can perform numerous analyses. It can perform complex, minimally invasive analyses of single cells without specialized equipment and personnel. This inexpensive, accessible platform has broad applications in precision diagnostics and is a step toward the democratization of medical technologies. (See pp. E1306–E1315.)
Estrogen receptor α wields treatment-specific enhancers between morphologically similar endometrial tumors
Marjolein Droog, Ekaterina Nevedomskaya, Gwen M. Dackus, Renske Fles, Yongsoo Kim, Harry Hollema, Marian Mourits, Petra M. Nederlof, Hester H. van Boven, Sabine C. Linn, Flora E. van Leeuwen, Lodewyk F. A. Wessels, and Wilbert Zwart
This study shows that the hormonal environment in which a tumor originates may affect a hormone receptor's enhancer usage. We further show that enhancer function is less tissue specific than previously thought. By implementing ChIP sequencing in a unique patient cohort, we compared estrogen receptor α (ERα) profiles in endometrial tumors that developed in different hormonal environments and integrated these comparisons with transcriptomic data. Our data show that tumors associated with therapeutic intervention have a distinct ERα DNA-binding signature with regulatory potentials that resemble ERα-binding patterns in breast cancer. These results highlight the value of cistromic analyses in clinical specimens, which enabled us to distinguish subtypes of tumors on the level of transcriptional regulation. (See pp. E1316–E1325.)
Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP)
Martín Hugo, Alejandra Martínez, Madia Trujillo, Damián Estrada, Mauricio Mastrogiovanni, Edlaine Linares, Ohara Augusto, Federico Issoglio, Ari Zeida, Darío A. Estrín, Harry F. G. Heijnen, Lucía Piacenza, and Rafael Radi
Trypanosoma cruzi, the causative agent of Chagas disease, affects 8–10 million people in Latin America. Parasite antioxidant systems are essential for parasite survival and infectivity in the vertebrate host. Herein, we characterized the enzymic properties, subcellular localization, and contribution to parasite virulence of a T. cruzi hybrid type A member of class I heme peroxidases. The enzyme reacts fast with hydrogen peroxide and utilizes both ferrocytochrome c and ascorbate as reducing substrates [T. cruzi ascorbate peroxidase (TcAPx)-cytochrome c peroxidase (CcP)]. A unique subcellular distribution of TcAPx-CcP in the infective stages suggests a role during parasite–host interactions. Infection of macrophages and cardiomyocytes, as well as in mice, confirmed the involvement of TcAPx-CcP in pathogen virulence as part of the parasite antioxidant armamentarium. (See pp. E1326–E1335.)
Reaction dynamics analysis of a reconstituted Escherichia coli protein translation system by computational modeling
Tomoaki Matsuura, Naoki Tanimura, Kazufumi Hosoda, Tetsuya Yomo, and Yoshihiro Shimizu
Biological systems are driven by multiple components and interactions that form a complex reaction network. We developed a method to analyze their dynamics by focusing on the component in temporal plateaus, or a quasi-stationary state (QSS). The analyses, using a computational model of a minimal in vitro protein synthesis system, showed that components in a QSS form clusters that grow over time. However, the growth is not in a linear fashion: The process involved collapse and regrowth of the formed clusters, where the collapse was closely related to the phase transition in the reaction network. These observations suggest that the studies focusing on the QSS might be useful for understanding of complex reaction dynamics. (See pp. E1336–E1344.)
Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling
Myong-Ho Jeong, Hyun-Ji Kim, Jung-Hoon Pyun, Kyu-Sil Choi, Dong I. Lee, Soroosh Solhjoo, Brian O'Rourke, Gordon F. Tomaselli, Dong Seop Jeong, Hana Cho, and Jong-Sun Kang
Upon injury, reactivated Wnt/β-catenin signaling is implicated in cardiac remodeling and cardiomyopathy, thus it is an attractive target for intervention of cardiac diseases. Here, we demonstrate a role of a cell surface receptor Cdon in preventing cardiac remodeling through suppression of Wnt signaling. Cdon−/− mice develop cardiac dysfunction and fibrosis with altered expression of remodeling genes. Cdon deficiency causes aberrant localization and function of gap junction protein connexin 43, correlating with hyperactivated Wnt signaling. Blocking of Wnt signaling in Cdon-depleted cardiomyocytes attenuates aberrant intercellular coupling. Conversely, Wnt activator causes aberrant activation of gap junction with decreased Cdon levels, suggestive of a feedback mechanism. These data suggest that Cdon is required for the control of Wnt signaling to prevent cardiac remodeling. (See pp. E1345–E1354.)
Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments
Robert W. Kensler, Roger Craig, and Richard L. Moss
Cardiac myosin binding protein C (cMyBP-C) is an important regulator of myocardial contraction, but its mechanism of action is unclear. In this study, we examined the structure of thick filaments from the hearts of mice in which the three serine residues that are phosphorylated by protein kinase A in the m-domain of cMyBP-C were replaced by either alanine or aspartic acid to mimic either the nonphosphorylated or phosphorylated state of cMyBP-C. In contrast to earlier work on rat cardiac filaments, the results support a model in which nonphosphorylated cMyBP-C stabilizes the relaxed/superrelaxed ordered "off-state" conformation of the heads while phosphorylation weakens the binding of the heads to the thick filament surface, increasing the probability of interaction with actin. (See pp. E1355–E1364.)
Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry
Jennifer Greaves, Kevin R. Munro, Stuart C. Davidson, Matthieu Riviere, Justyna Wojno, Terry K. Smith, Nicholas C. O. Tomkinson, and Luke H. Chamberlain
S-acylation, the attachment of different fatty acids onto cysteine residues, regulates the activity of a diverse array of cellular proteins. This reversible posttranslational modification is essential for normal physiology, and defects are linked to human disease. S-acylation is catalyzed by a large family of zDHHC S-acyltransferases that use a cellular pool of diverse fatty acyl-CoAs as substrates. Using chemically synthesized probes, we show that individual zDHHC enzymes have marked differences in fatty acid selectivity and identify the underlying molecular basis for this property. This study identifies how acyl chain heterogeneity of S-acylated proteins is generated and is significant because the chemical nature of the attached S-acyl chain can fundamentally impact protein behavior. (See pp. E1365–E1374.)
Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization
Alexandra Volodin, Idit Kosti, Alfred Lewis Goldberg, and Shenhav Cohen
Muscle wasting as occurs with disuse, spinal injuries, aging, and many diseases (including cancer, sepsis, and renal failure) results primarily from the accelerated destruction of the myofibrillar apparatus, although the molecular mechanisms for this effect are largely unclear. To gain insight into the sequence of events leading to myofibril destruction, we studied the atrophy induced by denervation. We found that phosphorylation and ubiquitination of the desmin cytoskeleton precede its depolymerization, which eventually causes myofibril destruction. We further uncovered a delayed phase in the atrophy process, which involves the induction of genes that facilitate myofibril breakdown, including the AAA-ATPase p97/VCP, by the transcription factor paired box 4 (PAX4). Consequently, desmin phosphorylation, p97/VCP, and PAX4 may represent new therapeutic targets to reduce myofibril breakdown during atrophy. (See pp. E1375–E1384.)
Myosin-driven transport network in plants
Elizabeth G. Kurth, Valera V. Peremyslov, Hannah L. Turner, Kira S. Makarova, Jaime Iranzo, Sergei L. Mekhedov, Eugene V. Koonin, and Valerian V. Dolja
A key feature of plant cells is rapid cytoplasmic streaming that is driven by myosin motors. However, specific mechanisms of myosin-dependent streaming are poorly understood. Here, we characterize a dense network of plant myosins and their receptors and adaptors that, jointly with myosins, appear to mediate cytoplasmic streaming through distinct endomembrane compartments. We additionally present data suggestive of a myosin-dependent nucleocytoplasmic trafficking pathway. The myosin network is an ancient functional module that was already present in the common ancestor of green algae and land plants but underwent a major expansion in the latter, probably contributing to land colonization by plants. (See pp. E1385–E1394.)
Targeting IRE1 with small molecules counteracts progression of atherosclerosis
Ozlem Tufanli, Pelin Telkoparan Akillilar, Diego Acosta-Alvear, Begum Kocaturk, Umut Inci Onat, Syed Muhammad Hamid, Ismail Çimen, Peter Walter, Christian Weber, and Ebru Erbay
Endoplasmic reticulum (ER) stress is linked to the development of complex metabolic diseases, including diabetes, obesity, and atherosclerosis. Irremediable ER stress can push the unfolded protein response (UPR) toward proinflammatory and proapoptotic signaling. The need to dissociate the adaptive UPR responses from its destructive outputs has become a major challenge for therapeutic strategies aimed at mitigating ER stress that is often observed in chronic diseases. Our findings show that inositol-requiring enzyme 1 (IRE1) plays a critical role in metaflammation and that administering IRE1-specific inhibitors to hyperlipidemic mice counteracts atherosclerosis progression. (See pp. E1395–E1404.)
An amidase is required for proper intercellular communication in the filamentous cyanobacterium Anabaena sp. PCC 7120
Zhenggao Zheng, Amin Omairi-Nasser, Xiying Li, Chunxia Dong, Yan Lin, Robert Haselkorn, and Jindong Zhao
The filamentous cyanobacterium Anabaena has become a widely studied model to determine the molecular mechanisms involved in establishing and maintaining the pattern of heterocyst differentiation in response to the removal of fixed nitrogen from the environment. Heterocysts develop from vegetative cells, usually spaced about 10 cells apart, converting an oxic cell capable of division into an anoxic factory for nitrogen fixation that does not divide. Genetic analysis to elucidate the mechanisms of intercellular material exchange between heterocysts and vegetative cells is in an early phase. Here we show that an amidase is involved in the function of channels that penetrate the rigid peptidoglycan walls that separate cells in the filaments. (See pp. E1405–E1412.)
RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo
Twana Alkasalias, Andrey Alexeyenko, Katharina Hennig, Frida Danielsson, Robert Jan Lebbink, Matthew Fielden, S. Pauliina Turunen, Kaisa Lehti, Vladimir Kashuba, Harsha S. Madapura, Benedek Bozoky, Emma Lundberg, Martial Balland, Hayrettin Guvén, George Klein, Annica K. B. Gad, and Tatiana Pavlova
In order for cancer to develop, normal tumor-inhibitory fibroblasts need to change into tumor-promoting, cancer-associated fibroblasts. We created Ras homolog family member A (RhoA) gene knockout fibroblasts and found that even though these cells lacked common markers of classic cancer-associated fibroblasts, they had lost their normal tumor-inhibitory capacity and induced tumor-cell migration and proliferation in vitro and tumor growth in vivo. RhoA knock-out cells also showed an altered cytoskeleton, reduced contractile force, and induced stiffness of the fibroblasts. RhoA knockout also induced a loss of α-smooth muscle actin and an activated proinflammatory state, which was reflected by interference with a number of Rho signaling cascades. Our data indicate that RhoA is a key regulator of the switch from tumor-inhibitory to tumor-promoting fibroblasts. (See pp. E1413–E1421.)
Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation
Lun Zhou, Jielin Liu, Menglan Xiang, Patrick Olson, Alexander Guzzetta, Ke Zhang, Ivan P. Moskowitz, and Linglin Xie
Dominant GATA4 mutations cause congenital heart defects in humans, but the mechanistic basis whereby Gata4 haploinsufficiency causes disease is unknown. We demonstrate that Gata4 is required in a subset of cardiac progenitor cells called the "second heart field" for cardiac septation. Furthermore, we identified two distinct pathways downstream of Gata4, phosphatase and tensin homolog (Pten)-modulated cell-cycle transition and Hedgehog signaling, which appear to act independently. Restoration of either Pten-mediated cell-cycle transition or Hedgehog signaling restored cardiac septation in Gata4-mutant mice, suggesting that defects in both pathways are required for disease causation. This work generates a working model for understanding the molecular basis of human congenital heart disease caused by dominant transcription factor mutations. (See pp. E1422–E1431.)
Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia
Shujuan Chen, Wenqi Lu, Mei-Fei Yueh, Eva Rettenmeier, Miao Liu, Johan Auwerx, Ruth T. Yu, Ronald M. Evans, Kepeng Wang, Michael Karin, and Robert H. Tukey
In many parts of the world, especially in low- and middle-income countries, severe neonatal hyperbilirubinemia (SNH) is associated with substantial mortality and long-term morbidities. Although the immediate and rapid rise in total serum bilirubin (TSB) originating from lysis of red blood cells has been linked to genetic predisposition, preterm births, and blood type incompatibilities, the inability to efficiently metabolize bilirubin results from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1). In this study, the mechanism associated with delayed expression of the human UGT1A1 gene in neonatal mice that are humanized for the UGT1 locus is described. Neonatal humanized UGT1 (hUGT1) mice develop SNH and control TSB levels by nuclear receptor corepressor 1 (NCoR1)-directed repression of intestinal epithelial cell maturation, an event linked to expression of the UGT1A1 gene. (See pp. E1432–E1440.)
Reconciling fisheries catch and ocean productivity
Charles A. Stock, Jasmin G. John, Ryan R. Rykaczewski, Rebecca G. Asch, William W. L. Cheung, John P. Dunne, Kevin D. Friedland, Vicky W. Y. Lam, Jorge L. Sarmiento, and Reg A. Watson
Phytoplankton provide the energy that sustains marine fish populations. The relationship between phytoplankton productivity and fisheries catch, however, is complicated by uncertainty in catch estimates, fishing effort, and marine food web dynamics. We enlist global data sources and a high-resolution earth system model to address these uncertainties. Results show that cross-ecosystem fisheries catch differences far exceeding differences in phytoplankton production can be reconciled with fishing effort and variations in marine food web structure and energy transfer efficiency. Food web variations explaining contemporary fisheries catch act to amplify projected catch trends under climate change, suggesting catch changes that may exceed a factor of 2 for some regions. Failing to account for this would hinder adaptation to climate change. (See pp. E1441–E1449.)
Selection maintains signaling function of a highly diverged intrinsically disordered region
Taraneh Zarin, Caressa N. Tsai, Alex N. Nguyen Ba, and Alan M. Moses
Intrinsically disordered regions (IDRs) are widespread, have diverse functions, and are involved in human disease. Because standard sequence analysis methods identify little sequence homology in IDRs, it is not currently understood whether (or how) the functions of these protein regions are preserved over evolution. Here we show that orthologous IDRs can preserve regulatory functions despite near-complete sequence divergence. This suggests that natural selection maintains aggregate molecular properties in IDRs, which we propose to be quantitative traits. Consistent with this, we find signatures of stabilizing selection on the electrostatic properties of IDRs. Thus, in analogy to the rapid evolution of noncoding DNA in eukaryotic enhancers, divergence in primary amino acid sequence does not imply functional divergence in IDRs. (See pp. E1450–E1459.)
Dynamics of genome size evolution in birds and mammals
Aurélie Kapusta, Alexander Suh, and Cédric Feschotte
Deciphering the forces and mechanisms modulating genome size is central to our understanding of molecular evolution, but the subject has been understudied in mammals and birds. We took advantage of the recent availability of genome sequences for a wide range of species to investigate the mechanism underlying genome size equilibrium over the past 100 million years. Our data provide evidence for an "accordion" model of genome size evolution in birds and mammals, whereby the amount of DNA gained by transposable element expansion, which greatly varies across lineages, was counteracted by DNA loss through large segmental deletions. Paradoxically, birds and bats have more compact genomes relative to their flightless relatives but exhibit more dynamic gain and loss of DNA. (See pp. E1460–E1469.)
Low escape-rate genome safeguards with minimal molecular perturbation of Saccharomyces cerevisiae
Neta Agmon, Zuojian Tang, Kun Yang, Ben Sutter, Shigehito Ikushima, Yizhi Cai, Katrina Caravelli, James A. Martin, Xiaoji Sun, Woo Jin Choi, Allen Zhang, Giovanni Stracquadanio, Haiping Hao, Benjamin P. Tu, David Fenyo, Joel S. Bader, and Jef D. Boeke
As the use of synthetic biology grows, there is an increasing need to ensure biocontainment both to protect engineered proprietary strains and to mitigate potential inadvertent or advertent release to the environment. Here, we screen for the best-performing construct for essential gene-dependent transcriptional safeguards (SGs) in yeast. We have engineered strains that have near-WT fitness and a low escape rate, and grow in the presence of a nanomolar concentration of essential supplement. We also improved our "safeguard" construct by promoter engineering, as well as by analyzing a series of potential "decoy molecules" that could be used to mask the existence of critical chemical ligands required to grow the SG strain. (See pp. E1470–E1479.)
TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity
Dominika Lukas, Nir Yogev, Junda M. Kel, Tommy Regen, Ilgiz A. Mufazalov, Yilang Tang, Florian Wanke, Boris Reizis, Werner Müller, Florian C. Kurschus, Marco Prinz, Ingo Kleiter, Björn E. Clausen, and Ari Waisman
Smad7 is a negative regulator of TGF-β signaling, a cytokine with anti-inflammatory properties. Although TGF-β was implicated in the development and function of dendritic cells (DCs), the in vivo role of Smad7 in DCs remains elusive. Here, we demonstrate that DC-specific Smad7 deletion affects the development of splenic CD8+CD103+ DCs by regulating expression of the transcription factors Batf3 and IRF8. In addition, Smad7 directs DC function by regulating the expression of indoleamine 2,3-dioxygenase in response to IFN-γ signaling. Hence, absent Smad7 in DCs mediates resistance of mice to the development of autoimmunity via protective regulatory T-cell induction. These findings demonstrate that Smad7 expression governs splenic DC subset differentiation and affects tolerogenic DC function in vivo. (See pp. E1480–E1489.)
Dnmt3a restrains mast cell inflammatory responses
Cristina Leoni, Sara Montagner, Andrea Rinaldi, Francesco Bertoni, Sara Polletti, Chiara Balestrieri, and Silvia Monticelli
Methylation of genomic DNA is an epigenetic modification at the interface between genetic information and environmental stimuli underlying many phenotypic variations in the human population as well as the pathogenesis of complex diseases. Accordingly, mutations in the de novo DNA methyltransferase enzyme DNMT3A have been identified in a number of diseases, including mast cell-related disorders. However, the role of DNA methylation and DNMT3A in regulating mast cell physiology still needs to be elucidated. Here, we found that Dnmt3a plays a critical role in modulating mast cell responsiveness to acute and chronic stimulation, potentially implicating DNA methylation-mediated processes in all types of mast cell-related diseases. (See pp. E1490–E1499.)
SGK3 sustains ERα signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis
Yuanzhong Wang, Dujin Zhou, Sheryl Phung, Charles Warden, Rumana Rashid, Nymph Chan, and Shiuan Chen
Acquired aromatase inhibitor (AI) resistance is a major clinical issue in the treatment of estrogen receptor alpha (ERα)-positive breast cancer. Most AI-resistant breast tumors still express ERα and rely on its signaling for growth. The current study shows that serum- and glucocorticoid-inducible kinase 3 (SGK3), a kinase transcriptionally regulated by ERα in breast cancer, sustains ERα signaling and drives the acquired AI resistance by protecting against endoplasmic reticulum (EnR) stress-induced ERα downregulation and cell death through preserving sarcoplasmic/EnR calcium ATPase 2b (SERCA2b) function. Our study reveals regulation of ERα expression mediated by the EnR stress response and highlights SGK3 inhibition as a potential effective treatment of acquired AI-resistant breast cancer. (See pp. E1500–E1508.)
Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy
Caroline J. Woo, Verena K. Maier, Roshni Davey, James Brennan, Guangde Li, John Brothers II, Brian Schwartz, Susana Gordo, Anne Kasper, Trevor R. Okamoto, Hans E. Johansson, Berhan Mandefro, Dhruv Sareen, Peter Bialek, B. Nelson Chau, Balkrishen Bhat, David Bullough, and James Barsoum
Autosomal recessive mutations or deletions of the gene Survival Motor Neuron 1 (SMN1) cause spinal muscular atrophy, a neurodegenerative disorder. Transcriptional up-regulation of a nearly identical gene, SMN2, can functionally compensate for the loss of SMN1, resulting in increased SMN protein to ameliorate the disease severity. Here we demonstrate that the repressed state of SMN2 is reversible by interrupting the recruitment of a repressive epigenetic complex in disease-relevant cell types. Using chemically modified oligonucleotides to bind at a site of interaction on a long noncoding RNA that recruits the repressive complex, SMN2 is epigenetically altered to create a transcriptionally permissive state. (See pp. E1509–E1518.)
Bordetella PlrSR regulatory system controls BvgAS activity and virulence in the lower respiratory tract
M. Ashley Bone, Aaron J. Wilk, Andrew I. Perault, Sara A. Marlatt, Erich V. Scheller, Rebecca Anthouard, Qing Chen, Scott Stibitz, Peggy A. Cotter, and Steven M. Julio
Bordetella spp. includes Bordetella pertussis, the causal agent of whooping cough. The Bordetella virulence gene (BvgAS) two-component regulatory system (TCS) is considered the "master virulence regulator" in Bordetella, as it controls expression of all known virulence factor-encoding genes. We show here that another TCS, PlrSR, is required for BvgAS activity in the lower respiratory tract (LRT) and for virulence even when BvgAS is rendered constitutively active, suggesting that it controls critical functions for bacterial survival in the LRT independently of BvgAS. Our data introduce a new layer of complexity to a paradigm of Bordetella virulence control that has held for more than 30 y, and they indicate the existence of previously unknown bacterial factors that may serve as vaccine components and therapeutic targets. (See pp. E1519–E1527.)
ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection
Anna Vysochan, Arjun Sengupta, Aalim M. Weljie, James C. Alwine, and Yongjun Yu
Viruses rely completely on host cell metabolism to provide the building blocks and energy required for producing progeny virions. Infection by human cytomegalovirus (HCMV) induces significant alterations in glucose metabolism by increasing glucose uptake and glycolysis as well as redirecting glucose carbon to support the synthesis of biomolecules such as lipids. The significance of acetate as a nutrient has been ignored for a long period. Our studies show that glucose carbon can be converted to acetate and used to make cytosolic acetyl-CoA by acetyl-CoA synthetase short-chain family member 2 (ACSS2) for lipid synthesis, which is important for HCMV-induced lipogenesis and the viral growth. The study provides greater understanding of HCMV pathogenesis and suggests strategies to develop antiviral therapies. (See pp. E1528–E1535.)
Proteomic analysis reveals O-GlcNAc modification on proteins with key regulatory functions in Arabidopsis
Shou-Ling Xu, Robert J. Chalkley, Jason C. Maynard, Wenfei Wang, Weimin Ni, Xiaoyue Jiang, Kihye Shin, Ling Cheng, Dasha Savage, Andreas F. R. Hühmer, Alma L. Burlingame, and Zhi-Yong Wang
Studies in mammalian systems have shown important functions of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins (O-GlcNAcylation) in a wide range of cellular, physiological, and disease processes. Genetic evidence indicates that O-GlcNAcylation is essential for plant growth and development. However, very few O-GlcNAc–modified proteins have been identified in plants. Here, we report identification of 262 O-GlcNAc–modified proteins in Arabidopsis, revealing both conserved and distinct functions of O-GlcNAc modification in plants. This study uncovers potentially important functions of O-GlcNAcylation in many cellular and developmental pathways and also provides a large number of modification sites for further genetic and molecular dissection of these specific functions. Our study provides the framework of an O-GlcNAc modification network underlying plant growth and development. (See pp. E1536–E1543.)
Loss of GET pathway orthologs in Arabidopsis thaliana causes root hair growth defects and affects SNARE abundance
Shuping Xing, Dietmar Gerald Mehlhorn, Niklas Wallmeroth, Lisa Yasmin Asseck, Ritwika Kar, Alessa Voss, Philipp Denninger, Vanessa Aphaia Fiona Schmidt, Markus Schwarzländer, York-Dieter Stierhof, Guido Grossmann, and Christopher Grefen
Root hairs are unicellular extensions of the rhizodermis, providing anchorage and an increase in surface area for nutrient and water uptake. Their fast, tip-focused growth showcases root hairs as an excellent genetic model to study physiological and developmental processes on the cellular level. We uncovered a root hair phenotype that is dependent on putative Arabidopsis orthologs of the Guided Entry of Tail-anchored (TA) proteins (GET) pathway, which facilitates membrane insertion of TA proteins in yeast and mammals. We found that plants have evolved multiple paralogs of specific GET pathway components, albeit in a compartment-specific manner. In addition, we show that differential expression of pathway components causes pleiotropic growth defects, suggesting alternative pathways for TA insertion and additional functions of GET in plants. (See pp. E1544–E1553.)
PPR-SMR protein SOT1 has RNA endonuclease activity
Wen Zhou, Qingtao Lu, Qingwei Li, Lei Wang, Shunhua Ding, Aihong Zhang, Xiaogang Wen, Lixin Zhang, and Congming Lu
Our results demonstrate that SUPPRESSOR OF THYLAKOID FORMATION 1 (SOT1), an Arabidopsis pentatricopeptide repeat (PPR) protein with a small MutS-related (SMR) domain, has endonuclease activity. The SMR moiety of SOT1 performs the endonucleolytic maturation of 23S and 4.5S rRNA through the PPR domain specifically recognizing a 13-nucleotide RNA sequence in the 5′ end of the chloroplast 23S–4.5S rRNA precursor. Our results also show that SOT1 can be engineered to recognize and cleave a predicted RNA substrate. Our findings suggest that SOT1 could be used as a tool for RNA manipulation in the future. (See pp. E1554–E1563.)
Human and rat gut microbiome composition is maintained following sleep restriction
Shirley L. Zhang, Lei Bai, Namni Goel, Aubrey Bailey, Christopher J. Jang, Frederic D. Bushman, Peter Meerlo, David F. Dinges, and Amita Sehgal
It is widely presumed that there is a relationship between sleep and the gut microbiome because both sleep restriction and dysbiosis of the gut microbiome are associated with metabolic diseases such as obesity and diabetes. Here, we report sleep restriction over several consecutive days does not overtly influence the composition of the microbiome of either rats or humans, despite both species showing other changes associated with sleep loss. These analyses suggest that sleep loss and microbial dysbiosis have independent effects on the development of metabolic diseases. (See pp. E1564–E1571.)
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- Multifunctional, inexpensive, and reusable nanoparticle-printed biochip for cell manipulation and diagnosis
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- Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy
- Bordetella PlrSR regulatory system controls BvgAS activity and virulence in the lower respiratory tract
- ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection
- Proteomic analysis reveals O-GlcNAc modification on proteins with key regulatory functions in Arabidopsis
- Loss of GET pathway orthologs in Arabidopsis thaliana causes root hair growth defects and affects SNARE abundance
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ZooFit Hits Dallas « ZooFit
It's taken me a few days to decompress, but I'm back to normal and proud of ZooFit. I just have to toot my horn a little. After I got a little shut-eye and power naps. Last week, I was a key sponsor for the Texas Regional AAZK/AZVT Symposium held in Dallas. I provided breakfast to...
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Let's Turn Up Sweater Dress
€17.00 €35.00
style #AGG78955Add to Crushes
Let's Turn Up Sweater Dress
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Write some Articles $2.5 per 500 words
Bütçe $30-250 AUD
We are looking for professional native content writer for different type of content writing job like article, blog, product description, review, etc. on various topics.
Pay rate is $2.5 per 500 words ($0.5 per 100 words ) and it will vary depend on the word length. (For example: For a 1000 words article the pay rate will be $5).
Requirements to all writers:
1. Content must be informative, 100% grammatical error free and Copyscape pass.
2. Must have SEO content writing knowledge.
3. Writer must be able to deliver 2,500 words within 24 hours. Should strictly follow the deadline and requirements.
Bid at $50. Payment through this site as milestone payment system with each and every assignment.
Dedicated and passionate writer will get long tern opportunity and will get daily basis assignment.
No time waster please........
Thanks to all.
Happy Bidding!
Bu iş için 34 freelancer ortalamada $91 teklif veriyor
Hello there. My name is AJA. I have checked through your brief and can see you do like to write articles on different niches. I have 5 years of experience in article writing on different niches including, technology ar Daha Fazla
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Dear Hiring Manager, I have got your job posting and I've carefully gone through it. Therefore, I am very much interested to work in your project with all of your requirements. I am very proficient in English Gramma Daha Fazla
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Dear Requester, I have reviewed the requirement and as a motivated individual, I am extremely interested in the content writing role currently advertised on these platforms. I would like to bring attention that all Daha Fazla
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A little scary and a lot of work: Augusta University physical therapy students dive into the shark tank and come out stronger.
Dental College of Georgia celebrates 50th anniversary during Alumni Weekend
First flight, first snow, first place!
Save the date: State of the University
Academic Programs
Students; Fall 2018
The Department of Art and Design Capstone Artist Talk:: Group Four
Ribbon cutting for Nurse-Managed Health Center at AU Health
Department of Art & Design Senior Capstone Group Exhibitions Closing Receptions
DCG 50th Anniversary Celebration


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If you are a creative type, then you could make money online by designing and selling crafty products on Etsy. Etsy sells a range of beautiful and original items from independent suppliers. Categories range from jewelry, clothes, and accessories, to art, collectibles, and vintage. So if you have some stunning crafty creations, Etsy is the perfect platform from which to sell from.
The first follows the startup path we outlined above: You have a disruptive idea for an app or piece of software, you validate the idea with real customers, and then raise money to hire developers or a development studio to build, launch, and scale your software. If you've done everything right, your software will be accepted to the Apple and Google Stores and you'll make money every time someone downloads it or pays for a premium feature.
Great article, learned a lot from it! But I still really get it with the share trigger and right content. For instance, the influencers now care a lot about the new Koenigsegg Agera RS >> https://koenigsegg.com/blog/ (Car). I thought about an article like "10 things you need to know about the Koenigsegg Agera RS". The only problem is that I don't know which keywords I should use and how i can put in share triggers.
With drop shipping, you're effectively partnering with a manufacturer or wholesaler to sell their products. This way, you don't pay upfront costs to buy inventory, aren't sitting on unsold items taking up expensive warehouse space, and don't have to deal with shipping the products yourself. You simply create your site, fill it with drop shippable products, and drive in customers, with almost everything else done for you.
Though a long break is never suggested, there are times that money can be shifted and put towards other resources for a short time. A good example would be an online retailer. In the couple of weeks leading up to the Christmas holidays, you are unlikely to get more organic placement than you already have. Besides, the window of opportunity for shipping gifts to arrive before Christmas is ending, and you are heading into a slow season.
Google Analytics is an invaluable source of data on just about every conceivable aspect of your site, from your most popular pages to visitor demographics. Keep a close eye on your Analytics data, and use this information to inform your promotional and content strategies. Pay attention to what posts and pages are proving the most popular. Inspect visitor data to see how, where and when your site traffic is coming from.
The referee will have power to expand or limit the amount and duration of discovery. The referee may set or extend discovery deadlines or cutoffs for good cause, including a party's failure to provide requested discovery for any reason whatsoever. Unless otherwise ordered based upon good cause shown, no party shall be entitled to "priority" in conducting discovery, depositions may be taken by either party upon 7 days written notice, and all other discovery shall be responded to within 15 days after service. All disputes relating to discovery which cannot be resolved by the parties shall be submitted to the referee whose decision shall be final and binding.
You are only allowed to access Accounts and Loans on the cash management system that are directly related to your tax identification number. If you request access to accounts or loans of your parent company, subsidiaries or affiliates, you are thereby warranting that they have authorized you to access their accounts through Cash Management Services in the same manner as your own Accounts and Loans and that their accounts and loans may be considered "Accounts" and "Loans," respectively, under this Access Agreement. You agree to provide us with their written authorization, in form and substance acceptable to us, evidencing your authority.
For a long time, digital marketers summed up the properties of direct and organic traffic pretty similarly and simply. To most, organic traffic consists of visits from search engines, while direct traffic is made up of visits from people entering your company URL into their browser. This explanation, however, is too simplified and leaves most digital marketers short-handed when it comes to completely understanding and gaining insights from web traffic, especially organic and direct sources.
So, I put together a free master course for you to take that spreads out all of the work involved in starting a blog, into a series of action-packed lessons. My free course breaks the entire process of starting a blog down into an incredibly simple 7-day process for going from 0 to publishing (and promoting) your first blog post in just 1 week. I can't recommend it enough.
Need more ideas on how to make money online? Another strategy is using webinars to market your product, service, or course. I've done webinars to promote my financial planning practice and to drum up interest in my online course for financial advisors. With a webinar, you're basically offering a lot of tips and advice for free — usually in a live format. At the end though, you pitch your paid product or service with the goal of securing a few deals.
You can work as a virtual assistant through dedicated websites, such as Upwork or Zirtual. All kinds of skills are needed, and compensation can vary anywhere between $10 per hour to $100 or more. Obviously, the higher pay will be to people who have more technical skills, such as web building skills and marketing. But you can find work doing administrative tasks at the lower end of the pay scale.
Tools & Resources: I've written a pretty comprehensive guide on the best web design software that covers both free and premium software packages. If you're serious about becoming a web designer, then I recommend purchasing the full Adobe Creative Cloud Suite. At $49.99 per month, this is probably a bargain considering what you can achieve with this set of tools.
Money can be earned and spent, saved and pilfered, invested and wasted. Not time. That's why time is far more valuable than money. The point? When you lack the luxury of time, making money online (or offline) can seem like an impossible task. How are you supposed to do that when you're working at a life-sucking nine-to-five job? While the stability of full-time employment might allow most to sleep well at night, it doesn't empower your creative juices to search for new income-producing strategies.
Upwork: This website offers a great marketplace for selling just about any professional service. You don't need a merchant account, website of your own or anything else for that matter. All you need to do is be able to provide a high-quality service at a reasonable price. But be informed, you will have to compete with many others that are constantly bidding on open jobs.
CashCrate sends out literally thousands of payments a month to users just like you who spend time completing surveys and offers on CashCrate.com. How do they do it? Well, they do surveys and offers regularly. It really adds up! Your initial goal should be to meet minimum payout, which is $20.00. Making $20.00 in free cash is actually quite easy considering there are hundreds of surveys and offers available, but here are a few tips to get you to your goal faster:
Love the five different area of investigation that you went over, great way to analyze and diagnosis the issue. I would also definitely agree doing a rankings comparison between the two time frames, and not only check what your Google ranking is, but also track the search volume for your keywords to see if it has fluctuated or gone down. Google Trends is a great tool for this as well, as one of your keywords that your ranking for may have just lost popularity online.
Except as expressly set forth in this Access Agreement, Bank makes no, and hereby disclaims any and all, representations or warranties, express or implied, in law or in fact, whatsoever to you or to any other person as to the services or any aspect thereof, including (without limitation) any warranty of merchantability, fitness for a particular purpose, quality, accuracy, or suitability. You agree that no oral or written advice or representation obtained from any Bank employee or representative will create a warranty or representation for purposes of this Access Agreement or any Services to be performed pursuant hereto. Bank makes no representation or warranty, either express or implied, to you as to any computer hardware, software, or equipment used in connection with the services (including, without limitation, your computer systems or related equipment, your software, or your internet service provider or its equipment), or as to the suitability or compatibility of Bank's software, internet delivered service, equipment or communication interfaces with those that you use, or as to whether any software or internet delivered service will perform in an uninterrupted manner, including (but not limited to) any warranty of merchantability or fitness for a particular purpose.
Ohio: SCIL, Inc. dba Speedy Cash, is a registered Ohio Credit Services Organization (CS.900174.000) operating pursuant to the Ohio Credit Services Organization Act. The actual lender is an unaffiliated third party. The Ohio laws against discrimination require that all creditors make credit equally available to all credit worthy customers, and that credit reporting agencies maintain separate credit histories on each individual upon request. The Ohio civil rights commission administers compliance with this law.
Brian, I recently found your blog by following OKDork.com. Just want to say you're really amazing with the content you put out here. It's so helpful, especially for someone like me who is just starting out. I'm currently writing posts for a blog I plan to launch later this year. I think my niche is a little too broad and I have to figure out how to narrow it down. I essentially want to write about my current journey of overcoming my fears to start accomplishing the dreams i have for blogging, business, and travel. In doing so, I will share the best tips, tools, and tactics I can find, as well as what worked, what didn't and why.
Cryptocurrency or digital currency is the next big thing in currency trading. It's a digital asset that is used as a method to pay for things, that isn't run by a government or institution. Bitcoin is the most well known digital currency and was trading at $200 per Bitcoin back in 2013. Now it is worth over $17k and is expected to be worth well over $1m in 2022.
This has become a popular business model for online entrepreneurs over the past several years, and will probably just continue to grow in popularity. The best thing about selling online courses is that once you do the up-front work in creating the course and setting up your marketing strategy, you can get paid over and over again for work you do once.


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This Home
Move in ready 2 bedroom, 1 bath condo with low HOA. This lovely condo features granite counter top in the kitchen, laminate wood floor on the first floor, newer F/S gas stove, great size bedrooms, walk-in closet and lots of natural light. The community of greenback estates has a great community pool for summer nights and spa.
The Details
County: Sacramento
School District: Sacramento
Subdivision: N/A
Acres: 0.0416
Property Subtype: Attached
HOA: Yes - $145
80 to Greenback, left in Auburn Blve., right on Donegal and right on Cavan Drive. Building is on the left hand side.
Stories: 2
Heat: Central
Air: Central
Exterior Type: Stucco,Wood
Foundation: Concrete Slab
Remodeled/Updated: No
Source -
Listing ID 19017983 - RE/MAX Gold Midtown


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Receiving a vigorous hand job but unable to nut one out. Just a lot of yanking and total regret.
via giphy
by Eaton Holgoode March 29, 2017
When someone comes out of the bathroom and sees you for the first time of the night, feels the need to be polite and shakes your hand. The problem is it's completey dry. It should still be slightly wet from the washing process. You just got dry handed!
It was a tough night at work. I hung out too close to the the restroom and got dry handed three times. Thank God I brought my Purell.
by Orange Mullet January 13, 2007
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MSA is a neurodegenerative disease of undetermined etiology, where ED is an early prominent sign occurring in 40% of men at the time of diagnosis (46,47). ED occurs in the majority of patients and the exact cause of it is unknown (48). Like PD, MSA likely affects the dopaminergic pathways within the brain essential for arousal (49). Orthostatic hypotension (OH) as a causal factor has been refuted by evidence that sildenafil can overcome reduced filling pressures, and the ED usually precedes the development of OH (46,49,50). Similar to other neurologic disorders that lead to ED, other disease related factors such as psychosocial stress, the burden of chronic illness, changed appearance, fatigue, decreased fine motor movement of fingers, immobility and diminished self-esteem due to loss of independence may contribute as well (51).
There are many different treatment options for erectile dysfunction but your individual diagnosis will determine which treatment option is right for you. It is important to realize that not all treatment options will work for everyone. A doctor who has specialized in men's sexual health (typically a urologist) will be the most qualified to discuss all of your treatment options with you. Many specialists will often encourage you to schedule additional follow up appointments to review how your treatment is working for you or if a different option may be more beneficial.
A common and important cause of ED is vasculogenic. Many men with ED have comorbid conditions such as hyperlipidemia, hypercholesterolemia, tobacco abuse, diabetes mellitus, or coronary artery disease (CAD). [6] The Princeton III Consensus recommends screening men who present with ED for cardiovascular risk factors; ED may be the earliest presentation of atherosclerosis and vascular disease. [7]
Erectile dysfunction - (ED) or impotence is sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual activity. A penile erection is the hydraulic effect of blood entering and being retained in sponge-like bodies within the penis. The process is most often initiated as a result of sexual arousal, when signals are transmitted from the brain to nerves in the penis.
There are hundreds of medications that have the side effect of ED and/or decreased libido. Examples of drugs implicated as a cause of ED include hydrochlorothiazides and beta-blocking agents. Medications used to treat depression, particularly the SSRIs such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Prozac Weekly, Sarafem), fluvoxamine (Luvox, Luvox CR), paroxetine (Paxil, Paxil CR, Pexeva) and sertraline (Zoloft), may also contribute to ED.9 Bupropion (Wellbutrin) which has a predominant effect on blocking the reuptake of dopamine is an antidepressant with lower incidence of ED.10 The side effects of 5ARIs occurring in fewer than 5% of patients can include gynaecomastia, ED, loss of libido and ejaculatory dysfunction.11
Psychological Causes of ED – Between 10% and 20% of ED cases have a psychological cause. Because arousal starts in the brain, psychological issues can be a significant contributing factor to erectile dysfunction. Mental health conditions like depression or anxiety can negatively impact your libido, making it more difficult for you to become aroused.
"Erectile dysfunction can be a very serious issue because it's a marker of underlying cardiovascular disease, and it often occurs before heart conditions become apparent. Therefore, men should consider improving their weight and overall nutrition, exercise more, drink less alcohol and have a better night's sleep, as well as address risk factors such as diabetes, high blood pressure and cholesterol.
Once a complete sexual and medical history has been completed, appropriate laboratory studies should be conducted. In the initial evaluation of ED, sophisticated laboratory testing is rarely necessary. For example, serum testosterone (and sometimes prolactin) is typically only useful when the patient demonstrates hypogonadal features or testicular atrophy, or when clinical history is suggestive. Additional hormonal evaluation may include thyroid stimulating hormone in those with a clinical suspicion of hypothyroidism or appropriate diabetes screening in those presenting with a concern for impaired glucose metabolism. If the patient has not been evaluated with a lipid panel and hyperlipidemia is suspected, measurement and appropriate referral to internal medicine or cardiology is recommended. In most cases, a tentative diagnosis can be established with a complete sexual and medical history, physical examination, and limited or no laboratory testing.
A variety of personal habits and lifestyle choices have been linked to ED. In some ways, this is a good thing, since habits can be broken and choices reconsidered. What's more, many of the lifestyle factors that contribute to sexual problems are ones that affect overall health and well-being, both physical and mental. Addressing these factors, therefore, can have benefits beyond improving erectile dysfunction.
Begot, I., Peixoto, T. C. A., Gonzaga, L. R. A., Bolzan, D. W., Papa, V., Carvalho, A. C. C., ... & Guizilini, S. (2015, March 1). A Home-Based Walking Program Improves Erectile Dysfunction in Men With an Acute Myocardial Infarction. The American Journal of Cardiology, 115(5), 5741-575. Retrieved from http://www.ajconline.org/article/S0002-9149(14)02270-X/abstract
However, a review of a United Kingdom medical record database found no evidence that the use of 5-alpha reductase inhibitors independently increase the risk for ED. In 71,849 men with benign prostatic hyperplasia (BPH), the risk of ED was not increased with the use of finasteride or dutasteride only (odds ratio [OR] 0.94), or a 5-alpha reductase inhibitor plus an alpha blocker (OR 0.92) compared with an alpha blocker only. In addition, the risk of ED was not increase in 12 346 men prescribed finasteride 1 mg for alopecia, compared with unexposed men with alopecia (OR 0.95). The risk of ED did increase with longer duration of BPH, regardless of drug exposure. [48]
*all photos are models and not actual patients.If you are interested in a prescription product, Hims will assist in setting up a visit for you with an independent physician who will evaluate whether or not you are an appropriate candidate for the prescription product and if appropriate, may write you a prescription for the product which you can fill at the pharmacy of your choice.
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This category of treatments includes external vacuum therapies: devices that go around the penis and produce erections by increasing the flow of blood in, while constricting the flow out. Such devices imitate a natural erection, and do not interfere with orgasm. External vacuum therapy mechanisms are approximately 95 percent successful in causing and sustaining an erection. All are portable, and costs range between $200-$500, covered under most insurance plans and Medicare Part B.
There are risks to prosthetic surgery and patients are counselled before the procedure. If there is a post-operative infection, the implant will likely be removed. The devices are reliable, but in the case of mechanical malfunction, the device or a part of the device will need to be replaced surgically. If a penile prosthesis is removed, other non-surgical treatments may no longer work.


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Look into natural remedies. If you're not interested in drugs and devices, see a homeopathic practitioner who can advise you as to what natural remedies might help manage your ED. While no studies have been conducted to prove that these remedies work for everyone, some men have found that acupuncture, herbal medicines, and "herbal Viagra" can be useful.
Alprostadil (also known as prostaglandin E1 [PGE1]) is the prominent known smooth-muscle dilator of the corpus cavernosum. Its mechanism of action is believed to be the promotion of intracellular accumulation of cyclic adenosine monophosphate, thereby causing decreased intracellular accumulation of calcium and resulting smooth muscle relaxation. Alprostadil can be delivered to the erectile tissue either via an intraurethral suppository that is massaged and then absorbed across the corpus spongiosum of the urethra to the corpora cavernosa, or directly injected into the corpora cavernosa. When administered urethrally, doses are substantially higher than when directly injected (typical dosing is 500 mcg to 1 mg intraurethral compared with 2.5 mcg to 20 mcg intracavernosal).
Neurogenic erectile dysfunction (NED) is a traditional classification of erectile dysfunction (ED) encompassing disorders impairing erections via neurologic compromise or dysfunction. The disorders compromising erections may act centrally, peripherally or both. The prevalence of neurogenic ED has been suspected to be between 10% and 19% of all causes of ED (1,2). However, several classically defined neurogenic processes may affect several components of the normal pathway to achieve erection e.g., multiple sclerosis (MS), diabetes mellitus, iatrogenic surgical and spinal cord injury. Each disease state has its own unique characteristics that require acknowledgement to fully understand their effect on ED.
With the pumps, erections last until the user hits the deflate button, which Kohler says "doesn't happen" accidentally. He adds that pump prostheses "are locker-room proof: Nobody can see that you have one." (Obviously, this is not the case with the always-on malleable rod option.) Implanted pumps are reliable, experts say, with more than 90 percent of the devices working for 12 to 15 years.
Erectile dysfunction is the inability to develop or maintain an erection that is rigid enough to allow penetration of the vagina, and therefore functional sexual intercourse. Generally, the term erectile dysfunction is applied if this occurs frequently (75% of the time) over a significant period if time (several weeks to months). If this is the case, the term impotence may also be used.
Depending on the cause, erectile dysfunction (ED) may be curable, but the condition is almost always treatable for most men. The first step is to visit your doctor, because several health conditions -- and the medications that treat them -- can cause ED. For example, cardiovascular (heart and blood vessel) disease causes arteries to narrow, which decreases blood flow to the penis and can cause trouble getting or maintaining an erection.
Erections are initiated and maintained via integration of afferent inputs in the supra sacral regions of the central nervous system. Regions of the brain cited to have key roles in the integration of signals include the medial amygdala, MPOA, periaqueductal gray matter, paraventricular nucleus (PVN), and ventral tegmentum among others (16). Studies in animal models, particularly in rats, have been paramount in identifying these key areas of signal integration and control. Electrostimulation of the MPOA, PVN and hippocampus lead to erection and lesions in these areas may prevent erection (17). Marson et al. injected labeled pseudorabies virus into rat corpora cavernosa and traced them to neurons in the spinal cord, brain stem and hypothalamus (18). Stimulation of the rat dorsal nerve led to increased firing in the MPOA not found elsewhere (19). Axonal tracing in animals have shows direct projections from the hypothalamus to the lumbosacral autonomic erection centers. Oxytocin and vasopressin have been identified as central neurotransmitters within the hypothalamic nuclei and may have a role in penile erection (17). These signaling studies identifying key areas of erectile response integration may explain how ED is associated with cerebrovascular accident (CVA), Parkinson's, epilepsy and MS.
Look into natural remedies. If you're not interested in drugs and devices, see a homeopathic practitioner who can advise you as to what natural remedies might help manage your ED. While no studies have been conducted to prove that these remedies work for everyone, some men have found that acupuncture, herbal medicines, and "herbal Viagra" can be useful.
Hormone deficiency or hypogonadism, whether primary or secondary, has been thought to impact erectile function. Approximately a third of men in the European Male Aging Study demonstrated low testosterone, suggesting that hypogonadism is overrepresented among men with ED.11 Hormone deficiency, however, is less frequently the cause of ED than diabetes or vascular disease. Many entities with a strong relationship to ED also diminish bioavailable testosterone, including obesity, diabetes, and opioid use. Other hormones involved in testosterone metabolism or availability, like thyroid stimulating hormone and gonadotropins, also may impact erectile quality, presumably through regulating bioavailable testosterone. Understanding the relationship between testosterone and ED has been impaired by a lack of standardized measurement of this hormone and the cyclic nature of its release and consumption.
Disclaimer: Results may vary. Consult your physician before beginning any health program. The website's content and the content provided within the PE Program is not a substitute for direct, personal, professional medical care and diagnosis ,is not intended to provide specific physical or mental health advice or any other advice whatsoever, and should not be relied upon in that regard. See our Terms of Use for more details.
Following a detailed discussion about the history of erectile dysfunction and its risk factors, your doctor will examine the testicles and penis to help determine the cause of erectile dysfunction. Your doctor will check reflexes and pulses in the area to see if problems with blood vessels or nerves are contributing to the erectile dysfunction. If necessary, your doctor will order tests to help diagnose erectile dysfunction.
It is normal for a man to have five to six erections during sleep, especially during rapid eye movement (REM). Their absence may indicate a problem with nerve function or blood supply in the penis. There are two methods for measuring changes in penile rigidity and circumference during nocturnal erection: snap gauge and strain gauge. A significant proportion of men who have no sexual dysfunction nonetheless do not have regular nocturnal erections.
Size matters, so get slim and stay slim. A trim waistline is one good defense — a man with a 42-inch waist is 50% more likely to have ED than one with a 32-inch waist. Losing weight can help fight erectile dysfunction, so getting to a healthy weight and staying there is another good strategy for avoiding or fixing ED. Obesity raises risks for vascular disease and diabetes, two major causes of ED. And excess fat interferes with several hormones that may be part of the problem as well.
Penis pumps produce erections by drawing blood, via air suction, into the penis. The devices consist of a cylindrical tube, 12 to 18 inches long, connected by a small air hose to a hand pump (on many models this resembles the squeeze mechanism on a blood pressure monitor). Users place the tube over the penis then pump to produce an erection. They must then place an elastic band around the base of the penis to keep the blood there and maintain the erection.
I think that a very powerful argument to young men who want to perform at the highest level is to point out the destructive nature of what they're doing. If they're having 18 drinks per week, if they're having three, four, five drinks at any one time, they're going to guarantee that their erections are not going to be at the highest level. I can't tell you the number of men who come in saying, they went out, they had a date, they had a big dinner– which, by the way, is also not a great thing for erections, because all the blood is now going to your gut instead of to the genital area. And how important lifestyle changes are to improving your performance, as well, if not better, than the medications. So make certain that you exercise modestly, not excessively. Make certain that you have a smaller meal on an evening or a day that you want to have a sexual encounter, because you want the blood to go, once again, to the penile area and not to your gut. And really, the whole idea of stress– if you're stressed out, if you're worried about a lot of things, if you're distracted, you can't initiate that psychic stimulus to your spinal cord and then ultimately to your penis. So stress management is incredibly important.
Size matters, so get slim and stay slim. A trim waistline is one good defense — a man with a 42-inch waist is 50% more likely to have ED than one with a 32-inch waist. Losing weight can help fight erectile dysfunction, so getting to a healthy weight and staying there is another good strategy for avoiding or fixing ED. Obesity raises risks for vascular disease and diabetes, two major causes of ED. And excess fat interferes with several hormones that may be part of the problem as well.
What happens is that the blood vessels of the penis are rather small, and a small amount of plaque in the penile arteries is going to result in erectile dysfunction. You need more plaque before the person's actually symptomatic from a heart problem, but they're linked. And so when anybody, any man has an erectile issue, it's incumbent upon the physician to make certain that their cardiac status is healthy.
Oral medicines: The best known ED medications are the Big Three: Viagra (sildenafil citrate, made by Pfizer, Inc.), Levitra (vardenafil HCl, made by Bayer and GlaxoSmithKline), and Cialis (tadalafil, made by Eli Lilly). The three are chemically very similar, and all have proven very effective. Because they are effective, convenient, and relatively inexpensive (about nine dollars per pill), these medicines have become the treatment of choice for most men experiencing ED.
Injection therapy involves injecting a substance into the penis to enhance blood flow and cause an erection. The Food and Drug Administration (FDA) approved a drug called alprostadil (Caverject) for this purpose in July of 1995. Alprostadil relaxes smooth muscle tissue to enhance blood flow into the penis. It must be injected shortly before intercourse. Another, similar drug that is sometimes used is papaverine—not yet been approved by the FDA for this use. Either drug may sometimes cause painful erections or priapism (uncomfortable, prolonged erections) that must be treated with a shot of epinephrine.
In rare cases, the drug Viagra ® can cause blue-green shading to vision that lasts for a short time. In rare cases, the drug Cialis® can cause or increase back pain or aching muscles in the back. In most cases, the side effects are linked to PDE5 inhibitor effects on other tissues in the body, meaning they are working to increase blood flow to your penis and at the same time impacting other vascular tissues in your body. These are not 'allergic reactions'.


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Thursday 190425
6:15pm Striking class Dynamic Warm Up – Mobility Prepare for.. A: WOD : 4 Rounds of: 15/12 Calorie Assault Bike 200m Farmers Carry (Blues/yellows) 9 Strict pull-ups ROM -WOD: Partner Smash Partner Supine Supine Spinal Rotation Cool down: Coaches choiceRead More
Wednesday 190424
U.S. Army Second Lieutenant Clovis T. Ray, 34, of San Antonio, TX, assigned to the 2nd Battalion, 35th Infantry Regiment, 3rd Brigade Combat Team, 25th Infantry Division, based in Schofield Barracks, HI, was killed on March 15, 2012, in Kunar province, Afghanistan, when insurgents attacked his unit with an improvised explosive device. He is survived […]Read More
Tuesday 190423
Dynamic Warm Up – Mobility Prepare for.. A: WOD 3 Rounds for Time of: 25 Burpee-box-jump overs (24/20) 15 C2B Pull-ups 500m Row B. Skill Work: Bar Muscle Ups Cool down: Calf stretch for 1 minute each side 30 Seconds/side of prone scorpion Seated straddle for 1 minute.Read More
Monday 190422
Dynamic Warm Up – Mobility Prepare for.. A:Strength E2MOM 3 Reps Clean And Jerk *Build up to a heavy 3 B: WOD "CF Open 13.4" Complete as many reps as possible in 7 minutes following the rep scheme below: 135/95 pound Clean and jerk, 3 reps (masters 115/65) 3 Toes-to-bar 135 pound Clean and jerk, […]Read More
Friday 190419
Dynamic Warm Up – Mobility Prepare for.. A:Strength 5×3 OHS for load: In-between sets do Weighted pull-ups 3-3-3-3-3 B: WOD "Severus Snape" 15 minute AMRAP of: 5 Strict pull-ups 10 Box jumps (30/24) 15 OH Walking lunges (45/35) ***Score a 5×3 in Wodify & weight used in pull-ups in Wodify ***Score rounds and reps in Wodify […]Read More
Thursday 190418
Dynamic Warm Up – Mobility Prepare for.. A: WOD "Albus Dumbledore" 9 Rounds of: 60 sec on; 60 sec off Row (cals) Bike (cals) Ski erg (cals) **Alt each minute B. Strength DB OH Walking Lunges 3 Rounds of: 15 m (50 feet) As heavy as possible without breaking during the 15m. Rest as needed […]Read More
Wednesday 190417
Dynamic Warm Up – Mobility Prepare for.. A: WOD "Harry Potter" 3 rounds of: 1 min at ea station for max reps Hip extension Knees-to-elbows Double unders Ring push-ups DB Clean & jerks (35/25) Rest 1 min btwn rnds ***Score total reps for all rounds in Wodify. (just like fight gone bad) Cool down: Coaches choiceRead More
Tuesday 190416
Dynamic Warm Up – Mobility Prepare for.. A: Strength Back Squat 1×5 (Back Squat for load: Find today's heaviest 5 rep) B: WOD Row, Row, Row 3 Rounds of: 1 min all out row effort Rest 3 min between attempts ***Score a 1 x 5 in Wodify ***Score total distance for 3 rounds in Wodify […]Read More
Monday 190415
Dynamic Warm Up – Mobility Prepare for.. A: WOD: Bar Muscle-up Nate AMRAP 20min of: 2 Bar muscle-ups 4 Handstand push-ups 8 Kettlebell swings (2/1.5 pd) ***Score total rounds & reps in Wodify Cool Down: 200m cool down walk. Smash delts and lats with a lacrosse ball up against a wall or on the ground for 2min/side […]Read More
Friday 190412
Saturday 8a Gymnastic Clinic – See you there! Dynamic Warm Up – Mobility Prepare for.. A: Strength: 5 x 3 Shoulder Press B. WOD "Quad Sprint" 2 RDS FOR TIME 20 Toes-to-bar 20 Slamballs (30/20) 20 Walking lunges 20 Row (cals)Read More


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This is the Help documentation for all editions G Suite provided by Netistrar. Note, Google provides all support for their products and services 24 hrs 7 days per week (details below) and Netistrar provides support for billing, upgrades and integration with other Netistrar products.
Getting started
Netistrar offers G Suite plans to customers at discounted rates providing customers with a single place to manage domain names and other internet assets, websites, certificates, and easy set up.
To purchase a G Suite plan for 1 or more users, simply compare the editions and then click on 'More details' to review specific details for each plan.
Having settled on a plan you then need to select the 'Number of seats' and the 'Payment Plan' for your product.
Number of Seats (Licenses)
Number of seats equates to number of users who will have an account in your organisation's G Suite account. The minimum number of users is 1. The first user added to the system will be a Super User with all Administration privileges in G Suite. Note, you can change this later if you have more than 1 user. You can assign Super User Privileges to any other user with an account in the same system.
Payment Plans
You have the choice of two payment plans, Monthly and Annual. Monthly gives you more flexibility, you can add/remove licenses/users at any time and cancel services without penalty.
With the Annual Plan you gain further discounts by committing to purchase the service for a full year in advance. You can add extra licenses at any time for an additional cost which is calculated on a pro-rata basis. You can reduce licenses only when renewing your plan at the end of the year.
Setting up your account
Having purchased your G Suite account, there are then two parts to setting up your account, first 'Setting up your primary domain name', and next 'Getting started in G Suite'. The first is a compulsory step required before you are able to operate your account. We aim to make this very easy for you, stepping you through a process which is made much easier because we have access to your domain name and DNS records as your Domain Name Registrar.
Setting up your primary domain name
From Dashboard > G Suite
From the G Suite section of you Dashboard, you should see your new subscription listed and marked as 'Awaiting Setup', as follows.
Click to 'Set up G Suite', and then follow instructions to select one of your domain names as the primarly domain name for your G Suite account.
Note: this will be the domain name that will become active for all your G Suite functions, e.g. myexampledomain.com will active for all your Gmail addresses.
Choose account contact. Note, we will pre-select a contact from your address book.
If you wish to use a different contact address please add a new contact into your address book.
From Dashboard > My account > My Address Book
This is the contact information that will be supplied to Google. Google may use this information to contact you directly. Note, Google requires an alternative email address at this stage to use as a secondary email address for setting up verification and recovery.
Note: you cannot use an email address that you might be planning to use when you have your new Gmail account.
Finally, DNS records - if we are managing your DNS records then you're all set - click to 'Set up G Suite for your domain name'. If we are not managing your DNS records please follow the instructions to configure your DNS records for your new G Suite account.
Once we have configured your G Suite account we will confirm the administration details, and Google will write to you directly with further instructions.
Getting started in G Suite
This stage is optional, there are a myriad of features and settings in the G Suite package for you to play with and get to learn over time. Some default functionality is provided at the outset with basic Gmail and Drive services provided out of the box.
First, decide who is going to be the Administrator of the account, and that person should become familiar all the options available and partcularly how to administer other users. The packages offer fine grained control of Users, Group and Permissions and the system can be configured with increasingly sophisticated levels of functionality as required.
For more Help and Information about administering and setting up your G Suite account visit the G Suite Learning Center.
Administering your account
To administer your account, follow the instructions to 'Sign in to your Admin console' at Google.
Support requests are raised through your
Support for G Suite and Gmail
Support for G Suite products are provided by Google. Support is available for your G Suite Administrator at G Suite Admin Help. Note: Netistrar cannot assist with G Suite product related queries.
You can contact G Suite Support using a number of options provided by Google at 'Contact G Suite Support'.
Adding more users
You can add more users to your G Suite subscription at any time. This will increase your Monthly subscription, or require a balancing payment in advance for Annual subscriptions.
From Dashboard > G Suite
Locate the correct G Suite account using the primary domain name. Click 'Manage G Suite' for that account, then click 'Add Users' from the Licensed Users section of the G Suite account summary screen.
Upgrading your subscription level
You can upgrade your G Suite subscription at any time. This will increase your Monthly subscription, or require a balancing payment in advance for Annual subscriptions.
From Dashboard > G Suite
Locate the correct G Suite account using the primary domain name. Click 'Manage G Suite' for that account, then click 'Upgrade' from the Subscription section of the G Suite account summary screen.
Upgrading your plan
You can change your payment plan from Monthly to Annual at any time. This will require a balancing payment in advance for Annual subscriptions.
From Dashboard > G Suite
Locate the correct G Suite account using the primary domain name. Click 'Manage G Suite' for that account, then click 'Settings' from the Billing section of the G Suite account summary screen.
For Monthly plans, you can cancel your subscription at any time and your plan will be scheduled to be deleted by Google at the end of the currently active monthly period.
For Annual plans, if you cancel your subscription before the end of the year you still pay for the full year, which is usually collected in advance.