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The essential role of gap junctional intercellular communication in the normal functioning of cells and its relationship to disease is only beginning to be understood. Gap junction channels assemble when connexins oligomerize into a connexon or hemichannel and dock with a connexon from a neighboring cell. These channels cluster at defined cell-cell contacts to form gap junctions. It is now apparent that most human cells express more than one of the 21 members of the connexin family. Therefore, in addition to homomeric, homotypic and homocellular gap junctions, a diverse arrangement of heteromeric, heterotypic and heterocellular gap junctions exist between contacting cells. The complexity of channel constituents and arrangements within tissues is thought to be critical in selective passage of small biological molecules, like secondary messengers, from one cell to another. Interestingly, the generation of connexin null mice has revealed a number of defects ranging from embryonic lethal to relatively normal animals. These findings highlight the importance of connexins in nearly every major organ in the body. In the last couple of decades, mutations in the genes encoding several members of the connexin (Cx) family of gap junction proteins have been linked to a number of human diseases including a wide array of skin diseases and developmental disorders, all of which are currently under investigation in the Laird laboratory.
Upon their discovery, pannexins (Panxs) gained instant attention from the gap junction community as they were shown to share sequence homology to the invertebrate gap junction proteins innexins. While the proposed role of pannexins as molecular constituents of intercellular channels remains controversial, there is general agreement that Panx1 forms large single membrane channels at the cell surface that serve a role in paracrine signaling. For example, Panx1 and Panx3-mediated ATP release plays a role in the propagation of calcium waves possibly through an interaction with purinergic receptors. ATP and UTP released via Panx1 channels also act as "find-me" signals for apoptotic cell clearance, regulate vascular tone and mucociliary lung clearance. Signaling through Panx1 channels can also be detrimental and contribute to cell death and seizures under ischemic or epileptic conditions, lead to inflammatory bowel disease and promote melanoma disease progression. Panx3 has been reported to play a role in the proliferation/differentiation of keratinocytes, chondrocytes and osteoblasts.
In recent years our laboratory cloned all three mouse pannexins, developed an arsenal of well-characterized and reliable site-specific antibodies and established an array of pannexin expression constructs. Through the use of this molecular toolkit we discovered that members of the pannexin family are long-lived, channel-forming glycoproteins that function at the cell surface in ATP release. Other studies highlighted the regulatory role of Panx1 and Panx3 in keratinocyte differentiation and maintenance of the epidermis while Panx3 was found to be important in osteoprogenitor cells, chondrocytes and osteoblasts. Therefore to fully understand the role of pannexin channels in skin and cartilage we will continue our biochemical and cell biological studies on pannexin function and employ genetically modified mice to dissect the unique and overlapping roles of Panx1 and Panx3 in vivo.


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Here's another round of eBook deals
Doll Bones is $1.99 – This is MG, but because I love Holly Black so much, go buy it!
A doll that may be haunted leads three friends on a thrilling adventure in this delightfully creepy novel from the New York Times bestselling cocreator of the Spiderwick Chronicles.
Zach, Poppy, and Alice have been friends forever. And for almost as long, they've been playing one continuous, ever-changing game of pirates and thieves, mermaids and warriors. Ruling over all is the Great Queen, a bone-china doll cursing those who displease her.
But they are in middle school now. Zach's father pushes him to give up make-believe, and Zach quits the game. Their friendship might be over, until Poppy declares she's been having dreams about the Queen—and the ghost of a girl who will not rest until the bone-china doll is buried in her empty grave.
Zach and Alice and Poppy set off on one last adventure to lay the Queen's ghost to rest. But nothing goes according to plan, and as their adventure turns into an epic journey, creepy things begin to happen. Is the doll just a doll or something more sinister? And if there really is a ghost, will it let them go now that it has them in its clutches?
The Last Dragonslayer is MG, too, but it's priced at $1.99, so how can you lose?
From Amazon:
In the good old days, magic was indispensable—it could both save a kingdom and clear a clogged drain. But now magic is fading: drain cleaner is cheaper than a spell, and magic carpets are used for pizza delivery. Fifteen-year-old foundling Jennifer Strange runs Kazam, an employment agency for magicians—but it's hard to stay in business when magic is drying up. And then the visions start, predicting the death of the world's last dragon at the hands of an unnamed Dragonslayer. If the visions are true, everything will change for Kazam—and for Jennifer. Because something is coming. Something known as . . . Big Magic.
Everybody See the Ants is $2.99
From Amazon:
Lucky Linderman didn't ask for his life. He didn't ask his grandfather not to come home from the Vietnam War. He didn't ask for a father who never got over it. He didn't ask for a mother who keeps pretending their dysfunctional family is fine. And he didn't ask to be the target of Nader McMillan's relentless bullying, which has finally gone too far.
But Lucky has a secret–one that helps him wade through the mundane torture of his life. In his dreams, Lucky escapes to the war-ridden jungles of Laos–the prison his grandfather couldn't escape–where Lucky can be a real man, an adventurer, and a hero. It's dangerous and wild, and it's a place where his life just might be worth living. But how long can Lucky keep hiding in his dreams before reality forces its way inside?
Michael L. Printz Honor recipient A.S. King's smart, funny and boldly original writing shines in this powerful novel about learning to cope with the shrapnel life throws at you–and taking a stand against it.
Shut Out is $2.99
From Amazon:
Most high school sports teams have rivalries with other schools. At Hamilton High, it's a civil war: the football team versus the soccer team. And for her part,Lissa is sick of it. Her quarterback boyfriend, Randy, is always ditching her to go pick a fight with the soccer team or to prank their locker room. And on three separate occasions Randy's car has been egged while he and Lissa were inside, making out. She is done competing with a bunch of sweaty boys for her own boyfriend's attention.
Lissa decides to end the rivalry once and for all: She and the other players' girlfriends go on a hookup strike. The boys won't get any action from them until the football and soccer teams make peace. What they don't count on is a new sort of rivalry: an impossible girls-against-boys showdown that hinges on who will cave to their libidos first. And Lissa never sees her own sexual tension with the leader of the boys, Cash Sterling, coming.

subset: commoncrawl


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Heartwarming Oatmeal w/Fruit and Nuts
Cinnamon, navel oranges and the sweetness of freshly squeezed red grapefruit juice highlight this warm and comforting breakfast tradition. Enjoy!
- Prep Time:10-15 minutes
Main Dishes
3/4 cup juice from a Texas red grapefruit
3/4 cup water
1/4 teaspoon ground cinnamon
1/8 teaspoon salt
2/3 cup old fashioned oats
1 tablespoon and 1 teaspoon brown sugar, firmly packed
2 navel oranges or mandarins, sectioned, chopped
4 dates (2 tablespoons), chopped
1 tablespoon almonds, slivered
In a medium saucepan, combine grapefruit juice, water, cinnamon, and salt; bring to a boil over HIGH heat. Stir in the oats and reduce the heat to MEDIUM-LOW. Cook for 5 minutes, stirring occasionally; remove from heat. Cover the oatmeal and let stand for 8 minutes, or until desired consistency is reached (it will continue to thicken as it stands). Stir in brown sugar. Spoon the oatmeal into bowls and top with navel oranges, dates and almonds.
Each serving provides: An excellent source of vitamin C, magnesium and fiber and a good source of vitamin A, folate, calcium and potassium.
Nutritional Information
- Calories: 276
- Carbohydrates: 59g
- Total Fat: 3.8 g
- Cholesterol: 0mg
- Saturated Fat: 0.4g
- Dietary Fiber: 7g
- % of Calories from Fat: 11%
- Sodium: 152 mg
- Protein: 6g
- Recipe Credit
Recipe courtesy of Produce for Better Health Foundation (PBH). This recipe meets PBH and Centers for Disease Control & Prevention (CDC) nutrition standards that maintain fruits and vegetables as healthy foods.
- Comments (0)
- 0 new comments


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Yenan large ceremonial hall theater: The original name Shanxi, Gansu and Ningxia border area large ceremonial hall, in 1956 changed the topic by Xie Juezai "the Yenan large ceremonial hall". Located at the Yenan South Gate, is the nation first batch of key Cultural relic preservation organ. Built in 1941 (1941). in 1971 instructed according to the central cultural relic department that the semblance maintained the original condition, the interior does has repaired. Mixes the construction for the brick, with steel timber trestle roof, pessimistic flat tiles cover. In the audience hall supposes attends a banquet 1020, the agglutination plank opens the repeat chair. Repairs when the west side additional construction has the audience to rest hall seven, the east side increases foreign guest restroom eight, outside the field makes up Ge Xiaolou 11 between for the dressing room, the clothing stage prop and the actor restroom, on the lobby supposes the projection room.
Shanxi, Shaanxi, or referred to Qin, also known as Shaanxi, China's northwest region, a province, the provincial capital Xi'an, located in the hinterland of China, the Yellow River and Yangtze River, located in east longitude 105 ° 29 '~ 111 ° 15', Latitude 31 ° 42 '~ 39 ° 35' between. East of Shanxi, Henan, west of Ningxia, Gansu, south of Sichuan, Chongqing, Hubei, Inner Mongolia, north, connecting China living in east and central region and the northwest and southwest of the important position. Because of the Shan Zhou (now Shan County in Henan Province) west of the, so called Shaanxi. Long history and profound culture. Longer period in the history of Shaanxi Province has been referred to as "Qin. "


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Currently BrowsingWeb Dev
The topic of e-commerce is increasingly relevant, with mobile commerce transactions estimated to total $3.2 trillion in 2017. With this incredible growth, the process of owning and running an e-commerce store is becoming ever easier, with solutions like Magento and OpenCart eliminating some of the steps of getting started. However, an alternative comes in the form of one of the world's most popular content management systems: WordPress.
WooCommerce is an open-source plugin for WordPress, providing the tools to turn your blog into an e-commerce platform, just like over 171,000 other retailers already have. This article will take a look at everying that is WooCommerce: what it is, how you can use it and where to start with installation. We'll also take a look at a few great plugins and themes for WooCommerce that you can pick up to get your store looking and running just how you'd like it! (more…)
WordPress may just be the most versatile web app ever. You could use it to power your site or blog (as we do here at AppStorm), or you could turn it into an eCommerce store, discussion board, photo gallery, or almost anything else with the wide range of plugins and themes you can add to your WordPress install.
But what if you want to use WordPress to do something totally new? You could always code your own theme or plugin, but that can be rather daunting to new users. Even if you"re already familiar with web programming, you"d have to learn the ins-and-outs out WordPress before you could get started.
That"s where the Script Manager plugin comes in. It"s designed to let you write HTML, PHP, SQL, and CSS code right inside WordPress, and then let you run that code anywhere you want in WordPress. You could make a custom widget, or add extra features to your WordPress dashboard, without learning any special WordPress coding tricks. In this tutorial, we"ll take a look at how you could build a simple calculator using HTML, Javascript, and CSS, right inside WordPress. You could use the same ideas to build anything else you"d like inside WordPress – your imagination"s the limit!
Before you start…
You won't have to do too much to get started writing new apps inside WordPress with Script Manager. You'll simply need to install the plugin on your site, or in a demo WordPress install on your own computer with tools like Wamp Server on Windows, MAMP server on a Mac, or XAMPP on almost any computer, period. Then, you can take a look at its documentation to familiarize yourself with its features. For the most part, though, if you've ever used a code editor, you should quickly feel at home coding in Script Manager in WordPress.
Now for the fun part: creating new features in WordPress with normal HTML, PHP, and Less code. We're going to make a calculator in WordPress, which shows how much you can do with just a bit of code in WordPress, even if you really wouldn't need a calculator in your site for real. We've included all the sample code in the article, so even if you aren't a developer yet, you could still follow along with the examples. We'll also use the following image assets in making the calculator, which you can download from the links below:
Getting ready to code in WordPress
It's always best to lay a good foundation for your project before you start. You'll need to plan out how each part of your app will work, and separate each part into the files you need to create. In this project, we'll create an AppBar as a small launcher in WordPress for your apps, and then will create a calculator app that you can launch from the AppBar. Each will have it"s own HTML file, JavaScript file, and Less file. We're using HTML for the app layout and structure, JavaScript to code the app's functionality, and the Less script, a CSS preprocessor built into Script Manager, to style the app.
Then, we want the calculator to be movable inside your webpage, so users can position it wherever they want. We'll use jQuery UI Draggable library to add this. It's built into WordPress, but we will actually have to tell WordPress to load it to use it in our app. You can do this by creating an Action script in Script Manager with the following names: wp_enqueue_scripts and admin_enqueue_scripts. The wp_enqueue_scripts action tell WordPress to load the JavaScript libraries for the user side, while the admin_enqueue_scripts action loads it in the Admin screen. We'll go ahead and define it for both, so you could use it in either location. To do this, click the 'Action' tab, then click the new button. You will be prompted for the name of the action script. Once you give the name and press 'new' under the name, you will see the new action script in the script list area. Select the script and place the code below:
This simply tells WordPress to load the jQuery UI core and draggable libraries on every page. This is the only WordPress specific coding for this project. All the rest is handled by WordPress shortcodes and standard HTML, Javascript, and CSS.
The next step is creating the different scripts. Under the HTML tab, create scripts with the names AppBar and calculator by pressing the "New button" to the left of the script list. Next, go to the "JavaScript" and "Less" tabs and do the same thing. That's the basic framework for building your app in WordPress. Now, let's fill in the gaps.
The AppBar
The AppBar launcher HTML code is simply a wrapper for the icons of the actual programs. The code for the AppBar HTML is:
Load the styling for the AppBar.
[CodeInsert lang='Less' name='AppBar' param="]
Define the div for holding the Apps.

Let's put a top spacer.

Add the different Apps to the bar.
[CodeInsert lang='HTML' name='calculator' param="]
Let's put a bottom spacer.

Load the AppBar specific javascript.
[CodeInsert lang='JavaScript' name='AppBar' param="]
Close out the AppBar.
The comments inside the code show the basic structure. First, we load in the styling for the AppBar. The AppBar is basically four divs: AppBarT that holds the other three divs in place, spaccerT that holds the image for the top of the AppBar and spaces it out, spacerM has the middle image as a repeating background and is were all the apps are stored, and spacerB which holds the bottom image as a background and spaces it out right. Just before closing the last div, we put the JavaScript for the AppBar.
Most of the work is in the Less scripts for styling the application. You can use the following Less script for your own AppBar, replacing the image URLs with your own site's URLs:
@AppBarColor: gray;
@AppBarradius: 10px;
@AppBarWidth: 35px;
#AppBarT {
position: fixed;
width: @AppBarWidth;
right: 0px;
top: 0px;
-moz-border-radius: @AppBarradius 0px 0px @AppBarradius;
border-radius: @AppBarradius 0px 0px @AppBarradius;
z-index: 999999;
img {
margin-left: 15px;
margin-top: 5px;
margin-bottom: 5px;
padding: 0px;
border: 0px;
&:active {
.spacerM {
width: 100%;
margin: 0px;
padding: 0px;
background-image: url(http://www.customct.com/wp-content/blogs.dir/3/files/2012/04/appbarM.png);
background-repeat: repeat-y;
.spacerT {
clear: both;
height: 21px;
width: 100%;
margin-top: 0px;
background-image: url(http://www.customct.com/wp-content/blogs.dir/3/files/2012/04/appbarT.png);
background-repeat: no-repeat;
.spacerB {
clear: both;
width: 100%;
height: 21px;
margin-bottom: 0px;
background-image: url(http://www.customct.com/wp-content/blogs.dir/3/files/2012/04/appbarB.png);
background-repeat: no-repeat;
That brings us to the last part of the AppBar: its JavaScript code. Just paste the following code in for the JavaScript AppBar script:
// Global Variables
// cctAppBar The object holder for the AppBar.
var cctAppBar;
// The AppBar object for creating the functionality of the calculator.
function AppBar() {
this.AppBarID = jQuery('#AppBarT'); // The jQuery object for the whole calculator.
// Method: toggle
// Description: this method is for toggling the display of the calculator.
this.init = function() {
var top = ((jQuery(window).height() – this.AppBarID.height()) / 2);
this.AppBarID.css( { 'top': (top + "px") });
// When the docment is done loading, execute this function. It will get the positioning of the
// AppBar fixed.
cctAppBar = new AppBar();
The JavaScript for just the AppBar is not really much. I declared a global variable to hold an instance of the AppBar class. In the AppBar class hold a jQuery variable for the AppBar div and the method init(). The init() method calculates the middle of the screen for the height of the AppBar and sets it to that location. The rest of the code simply waits for the page to fully load before creating an instance, assigning the global variable, and running the init() method. That is it!
As you can see, the AppBar is simply a container that looks nice for the applications to place their icons. We can always expand on this idea, but we have enough now for working with our calculator application.
The Applicaton Skeleton
Before we get into the application, let"s create the framework for all applications that will use the AppBar. The basic framework is this:
Insert the styling for the Application.
Give the image for embedding the Application into
the AppBar.
Give the actual HTML for the Application. By setting
the main div to be totally off the screen, the user
never sees it until clicking on the icon. Setting the
visibility to hidden does not work well with the
jQuery toggle() command.
Insert the javascript for running the application.
An application is broken down into four areas: the styling, an icon image to be shown in the AppBar, the HTML for the application, and finally the JavaScript code for running the application. When you really think about it, that is all there is to any application. Most of your work is in the styling and JavaScript functionality, so you can focus on what's most important in your application.
The Calculator Application
Now, lets take that framework and start adding our app to it. The first part is the styling done in the Less script. We add it with the "CodeInsert" shortcode as follows:
[CodeInsert lang='Less' name='calculator' param="]
[CodeInsert lang='JavaScript' name='numberFormat' param="]
Just put this code the the section designated. Additionally, if you'd like, you can include a 3rd party Javascript function for formatting your numbers nicely in the calculator, which you can copy and add to your app from PHP JS.
Now, we insert the icon image for the calculator. I made it after designing the application by taking a screen shot of the actual calculator. Then I resized it for the icon size. Just copy and paste this code, again replacing the image URL with your own site's image link once you've uploaded the image to your site:

The JavaScript function added to the onClick event for the anchor does all the work for the icon. When clicked, it will toggle the visibility of the application. The function is a method on the calculator object assigned to the "cctCal" global variable.
Next, we need to design the calculator user interface. When you think about a calculator, the first thing you think of is buttons. A calculator is a display are with a lot of buttons underneath. Since I was experimenting with different ideas on making the buttons, I created a PHP script to create the buttons. I just called the PHP script with a different name for each button to make the button. So, go to the PHP tab, create a script called "calculatorbutton", and place the following code there:
echo "

{$but}

";
I used both methods of embedding a varaible into a string that PHP allows. I was having trouble getting the quotes around the button name for sending to the "cctCal.keyPressed()" method, so this finally worked for me. The button is nothing more than a styled div with the id for that button"s name. Once again, most of the fancy graphic work is done in the Less script.
To put everything together, place the following code into the calculator HTML after the icon:

[CodeInsert lang='WPPHP' name='calculatorbutton' param="$but='7′;"]
[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="8″;']
[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="9″;']

[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="4″;']
[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="5″;']
[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="6″;']

[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="1″;']
[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="2″;']
[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="3″;']

[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="0″;']
[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but=".";']
[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="=";']

[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="÷";']
[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="X";']
[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="-";']
[CodeInsert lang='WPPHP' name='calculatorbutton' param='$but="+";']
As you can see, the calculator"s user interface is simply divs with unordered lists containing the buttons. The unordered lists makes spacing the buttons easier. The thing to notice here is how we pass the button"s name to the PHP code. We use the "CodeInsert" shortcode specifying the "calculatorbutton" PHP script with the "param" parameter set to defining the PHP variable "$but" to the name for that button. The "param" string is pasted at the beginning of the PHP script and evaluated all together. Since that string can be almost any size, you can really change the script with each calling of the script.
The calculator"s display is a span inside of a div for it. The div makes placement easier, while the span makes formatting easier.
Now that we have the structure for the calculator"s user interface, let"s style it with some Less code. In the calculator script under the Less tab, add the following code:
@calcolor: #63b8ee;
@gradstop: #468ccf;
@textshadow: #7cacde;
@butshadow: #bee2f9;
@topshadow: #3866a3;
@shadow: lightgray;
@radius: 10px;
@butsize: 30px;
@calsizex: 200px;
@calsizey: 300px;
@fontsize: 18px;
.butcolor() {
-moz-box-shadow:inset 0px 1px 0px 0px @butshadow;
-webkit-box-shadow:inset 0px 1px 0px 0px @butshadow;
box-shadow:inset 0px 1px 0px 0px @butshadow;
background:-webkit-gradient( linear, left top, left bottom, color-stop(0.05, @calcolor), color-stop(1, @gradstop) );
background:-moz-linear-gradient( center top, @calcolor 5%, @gradstop 100% );
filter:progid:DXImageTransform.Microsoft.gradient(startColorstr='@calcolor', endColorstr='@gradstop');
border:1px solid @topshadow;
font-size: @fontsize;
text-shadow:1px 1px 0px @textshadow;
&:hover {
background:-webkit-gradient( linear, left top, left bottom, color-stop(0.05, @gradstop), color-stop(1, @calcolor) );
background:-moz-linear-gradient( center top, @gradstop 5%, @calcolor 100% );
filter:progid:DXImageTransform.Microsoft.gradient(startColorstr='@gradstop', endColorstr='@calcolor');
&:active {
.calbutton(@width,@height) {
font-size: @fontsize;
text-align: center;
display: inline;
cursor: pointer;
span {
display: table-cell;
vertical-align: middle;
width: @width;
height: @height;
-moz-border-radius: @radius;
border-radius: @radius;
margin-left: 5px;
margin-right: 5px;
#cal {
background:-webkit-gradient( linear, left top, left bottom, color-stop(0.05, @calcolor), color-stop(1, @gradstop) );
background:-moz-linear-gradient( center top, @calcolor 5%, @gradstop 100% );
filter:progid:DXImageTransform.Microsoft.gradient(startColorstr='@calcolor', endColorstr='@gradstop');
border:1px solid @topshadow;
font-family: "Arial", Arial, sans-serif;
-moz-border-radius: @radius;
border-radius: @radius;
box-shadow: 10px 10px 5px @shadow;
height: @calsizey;
width: @calsizex;
z-index: 100;
position: fixed;
#caldis {
display: table-cell;
vertical-align: middle;
height: 60px;
width: 160px;
font-size: @fontsize;
text-align: right;
#caldisdiv {
background: @shadow;
-moz-border-radius: @radius;
border-radius: @radius;
margin-top: 25px;
margin-bottom: 20px;
margin-left: 10px;
margin-right: 10px;
box-shadow: inset 0px 1px 0px 0px lighten(@shadow,20);
#calkeypad {
display: block;
float: left;
margin-left: 10px;
display: block;
margin-top: 5px;
ul {
list-style-type: none;
height: @butsize;
margin: 0px 0px 15px 0px !important;
padding: 0px 0px 0px 0px;
li {
display: inline-block;
margin-right: 10px;
span {
#functions {
display: block;
float: right;
margin: 5px 10px 0px 0px !important;
ul {
list-style-type: none;
margin: 0px 0px 15px 0px !important;
padding: 0px 0px 0px 0px;
li {
display: block;
height: @butsize;
margin: 0px 0px 15px 0px !important;
span {
You will notice that I like to define several variables for colorization. Whenever possible, it is best to design in a way that can easily be changed. If you do not like the blue calculator, change the color values to something that is more suitable to your tastes. You do not have to hunt down all locations and figure out what needs changed. This helps down the road for specializing the same code for a different project as well. With plain CSS, you can not do it. But, Less to the rescue!
You will also notice that I defined two mixins (A term used in Less to define a CSS macro) for the buttons. The first defines the shading while the second describes the mechanics of the button. I used the website CSSButtonGenerator.com to help me define the shading for the button. Once I had the colorization I was looking for, I translated it to Less code and made all duplicate colors to a single define for that color. You will notice the "&:" used. This is Less" way to refer to the current element type. This allows the mixin to be used with any element in the HTML.
My favourite tweak is the ":active" CSS selector. For that selector, we make the element position relative and one pixel downward. This gives the button a look of being pushed down. It is a cute effect that gives the user more feedback, which hopefully makes them feel at home using the application.
The rest of the Less code defines the location and spacing for all the different elements. I used some "!important" tags to override some of the theme's CSS. Depending on your theme, this may be necessary. It would be nice to define a div element in which all theme related CSS is ignored! An iframe tag would do just that, but it has too many other limitations to be useful.
Finally, we need to code the guts of the calculator in JavaScript. Place the following code into the JavaScript calculator script:
// Globals used for the calculator.
// cctCal The global object for the calculator.
var cctCal;
// The Cal object for creating the functionality of the calculator.
function Cal() {
this.acc = '0'; // Currently displayed number. This should always be a string.
this.func = "; // Function to perform on the numbers.
this.state = 0; // current state of the calculator.
this.x = 0; // The first number with the second number in the acc. Make sure to keep it a number.
this.y = 0; // This is the second number for the operation. Remember to keep it a number too.
this.period = 0; // Flag to make sure only on period is given.
this.disID = jQuery('#caldis'); // The jQuery object for the display of the calculator.
this.calID = jQuery('#cal'); // The jQuery object for the whole calculator.
this.SetPos = false; // Have we placed the app yet?
// Method: display
// Description: This method is used to display the calculation.
this.display = function() {
if((new Number(this.acc)) > 100000000000) { // Check for the number being too big for the display area.
this.disID.html("Number too big.");
} else
this.disID.html(number_format(this.acc, 2, ".", ",")); // Set the new number into the display with two decimal places.
// Method: toggle
// Description: this method is for toggling the display of the calculator.
this.toggle = function() {
if(!this.SetPos) {
var winHeight = jQuery(window).height();
var winWidth = jQuery(window).width();
var top = ((winHeight – this.calID.height()) / 2);
var left = ((winWidth – this.calID.width()) / 2);
this.calID.css( { 'top': (top + "px"),
'left': (left + "px")
this.SetPos = true;
// Method: reset
// Description: This method is used to reset the calculator to the
// beginning state.
this.reset = function() {
this.state = 0;
this.acc = '0';
this.func = ";
this.period = 0;
this.x = 0;
this.y = 0;
// Method: keyPressed
// Description: This method is called with each key pressed on the calculator.
// Input: key The name of the key pressed.
this.keyPressed = function(key) {
switch(key) {
case '0':
case '1':
case '2':
case '3':
case '4':
case '5':
case '6':
case '7':
case '8':
case '9':
if(this.state == 2) // If we are doing a series of equals, then reset for the new number.
if(this.acc == '0') // If the acc is zero, then…
this.acc = key; // Just put the new digit.
else // otherwise …
this.acc = this.acc + key; // Add the number to the right of the acc contents.
this.display(); // Display the new number.
case '.': // Make sure we only put one decimal into the number.
if(this.period == 0) {
this.acc = this.acc + key;
this.period = 1;
case '-': // Save the oporator and setup for geting the next number.
case '+': // If we are doing a series of accums, then do the same thing.
case '÷':
case 'X':
if((this.state == 0)||(this.state == 2)) {
this.state = 1;
this.func = key;
this.x = new Number(this.acc);
this.acc = '0';
case '=':
if(this.state == 1) // We are ready to do an opperation. Set y to the number in the acc.
this.y = new Number(this.acc);
if(this.state > 0) {
switch(this.func) {
case '-': // Do a subtraction
this.acc = this.x – this.y;
case '+': // Do an addition
this.acc = this.x + this.y;
case '÷': // Do a divide
this.acc = this.x / this.y;
case 'X': // Do a multiply
this.acc = this.x * this.y;
this.state = 2; // Set the next state for continuing the current operation.
this.x = new Number(this.acc); // Set the current x to the acc for doing reoccuring operation.
this.display(); // Display the resulting number.
// When the docment is done loading, execute this function. It will enable the draggability of the
// calculator.
// Create the class for calculator to use and display the default number on the display. Then hide it.
cctCal = new Cal();
// Make the calculator draggable.
This is the most coding yet for this project. As I said, the JavaScript contains the functionality for the program. It is mostly an object called "Cal" that controls the calculator. "Cal" uses four methods and a state variable control scheme to control the logic. The comments in the code will help you to understand what it is doing. The four methods for the class are: display(), toggle(), reset(), and keyPressed().
display(): This method displays the current value in the "accum" class variable in a nice format for the screen. It also checks for the number being too large for the screen.
toggle(): This method simply toggles the visibility of the calculator. This is called each time the icon is clicked. The first time this is called, it will set the center of the browser window position as well.
reset(): This method resets the calculator to a beginning state.
keyPressed(): This is the main method for the calculator. In the beginning state, it keeps appending new numbers keyed in. When a function is pressed, the current number in the display is saved and the next state is started. Now, another number is created through the appending digits as before. When the equals key is pressed, the new number is stored also and the function pressed is performed on the two numbers. That new number is display and stored as the first number and the last state in set. Now, if the equal key is pressed again, the function last hit is performed with second stored number and the results of the last operation. When a number key is pressed, the reset method is called and the new number is stored up. All of this is handled by a few switch statements.
Final Results
After all the code above is in place, you can now embed the code into the page you what to see it or you can make it standard for all pages.
To put it into a specific page or post, simply go to that page or post to edit it, click the "Insert Code" button in the editor. It will show you a requester for the code. When you set the language, the name selector will have the name of all the scripts for that language. Therefore, select "HTML" and "AppBar". It will insert the following code into your post or page:
[CodeInsert lang='HTML' name='AppBar' param="]
Now, when you visit that page, the AppBar will appear to the right of the browser window:
This picture was taken from the demo page for this application.
Now, when you click the calculator icon, the full calculator will appear in the middle of the screen. If you move it, hide it, and then re-show it, it will appear where you last moved it to. Coding that much in a normal programming language for a desktop application would take so much more code! This is easy!
If you want the AppBar on all the pages in your website, simply create a "wp_footer" WordPress Action and put the embed code in it. Now, every page in your website will contain the webapp. Or, if you only want the app to appear on certain pages, you could write some simple PHP script to control it.
To make more webapps to be launched, just follow the skeleton code for applications to be launched and create you new application. Add the embed code for your new application after the calculator's embed code in the HTML for the "AppBar". Now, every time you embed the AppBar, you will see the new application"s icon as well.
That's it: you've just create a basic new app inside of WordPress with Script Manager! Perhaps you've never thought your blog needed a calculator, but this can give you an idea of what you can do. Feel free to check out the other Script Manager Tutorials for more ideas, or check out the Script Manager Forum to ask questions, share ideas, and more. Remember, your only limitation is what you can dream up!
A Global Village. There has never been a time when that adage was so true. Thanks to Internet, there are no boundaries anymore, well, almost. From communication to commerce everything happens in English. While people could just learn English, to reach more eyeballs, localization is the key. Translation services are available aplenty, including Google's fabulous free option.
But translation is one among a few steps you will have to conquer before going truly local globally. Smartling ensures that the best ideas are not locked up for English speakers alone. The service aspires to let everyone find, read and share their ideas online, in their preferred language. Shall we go ahead and figure out how it gets things done?
It's happened to all of us: you're standing in the shower, and all the sudden get a great idea for a new site, book, app, or anything else. You hurry getting ready for the day, thinking of everything you'll need for the project. Then it hits you: you should see if people are really going to be interested in your project or not. It'd be a great idea to make a quick site with a description of your project, perhaps updates about it or links to your other sites, and a way to let visitors sign up for updates.
So you've got several options. You could install WordPress on your server, grab one of the many landing page or "coming soon" themes available, then set it up like you want. Or you could whip out your text editor and hand code an HTML page and FTP it to your server. Only problem is, each of these options will take a fair bit of time, and you've still got to eat breakfast before you head out to work.
That's why landing page creators can be such a help. In a few moments, you can crank out a quick site to validate your idea and start getting users excited before you've even started writing your book or coding your app. Or, you can create a new page quickly to market your existing products to a specific group, to take advantage of current events, online memes, and more. Formstack is a popular online form creator we use across the Envato network of sites, and they've recently made a nice landing page creator to help you do just that. It brings the best of their form tools into a simple landing page creator that lets you create a quick landing page with forms, dynamic content, and more in only a few minutes. After the break, we'll see how you can put Formstack landing pages to use for your ideas.


text:
The picture is at the bottom of the page.
-----Original Message-----
From: firstname.lastname@example.com [mailto:firstname.lastname@example.com] On
Behalf Of firstname.lastname@example.com
Sent: 09 April 2005 18:02
To: email@example.com; Iain Strachan
Cc: Hon Wai Lai; email@example.com
Subject: Re: Switch to a web forum rather than email
The archives certainly strip them.
On Sat Apr 9 10:31 , Iain Strachan sent:
On Apr 9, 2005 2:57 PM, firstname.lastname@example.com
<firstname.lastname@example.com> wrote:
For me, there are features on a web based approach one can't use in
email. One can post pictures to aid in the discussion. This is
especially helpful when dealing with people who have never seen geology.
Is there any reason why one can't attach pictures to emails to ASA?
It's perfectly possible to attach them in emails normally, or even to
embed them inline. I've done it many times with Microsoft Outlook
Express, for instance.
On Sat Apr 9 5:39 , "Hon Wai Lai" sent:
If the motivation for a web-based forum is to deal with the heavy volume
of emails, it seems to me this can be adequately dealt with by each
member setting up filtering rules in their emailing software.
Most emailing softwares like Microsoft Outlook have filtering system (go
to Tools/Rules Wizard) that immediately moves arriving emails with
specified characteristics to specified folders. I set up rules that move
all emails sent to "email@example.com" into folder Inbox/ASA discussion.
This way, all non-personal emails are always separated from personal
ones which usually require a high level of attention. I would look at
the ASA discussion folder every few days, sort them by sender or by
subject header. This allows me to efficiently identify informative
emails from "noise" or uninteresting ones, as I know from past emails
the senders who tend to post informative materials. I can also quickly
delete a group of emails by the same subject header if the initial
postings are not of interest. Filtering rules can also delete emails
automatically with certain characteristics e.g. from particular senders.
If ASA members follow the convention of prefacing subject headers by
some standardised topic title in square brackets (e.g. [YEC], [ID],
[ethical issues], [Vernon's wacky ideas] etc.), the filtering rule can
move emails into subfolders in the designated "ASA discussion" folder.
This system imitates the threading system of a web-based forum.
I find emails very convenient. Checking up a website, and clicking on
links are troublesome. Moreover, I archive a small portion of the emails
into subfolders with an informative names for future reference.
> -----Original Message-----
> From: email@example.com
> [firstname.lastname@example.com','','','')">firstname.lastname@example.com] On
Behalf Of Terry M. Gray
> Sent: 09 April 2005 06:16
> To: firstname.lastname@example.com
> Subject: Re: Switch to a web forum rather than email
> Hi,
> I received 8 responses to my question. 6 of 8 favored the web forum
> style. 7 of 9 if you count my vote.
> I think it's worth a try--we will need to give it a month or so to
> get used to it and then we can reevaluate. I'm hoping to incorporate
> some features such as email or RSS notification of feeds. The
> software I'm currently using has a "check for posts since I last
> visited" feature that helps you track things.
> I could also send out a daily email to the list with a link to forums
> to help us transition.
> As you all know, we've been averaging 20 or so posts per day.
> Since we had such a small response, I'd like to allow for a bit more
> discussion, this time on-list. If you feel strongly about it one way
> or another (especially if you are against the idea), please post your
> opinion. Let's try not to get bogged down on this topic with quips
> and complaints but if you have a case to make one way or another
> please do it.
> I will also entertain a few questions about how it all works if
> you've never used anything like this before.
> --
> _________________
> Terry M. Gray, Ph.D., Computer Support Scientist
> Chemistry Department, Colorado State University
> Fort Collins, Colorado 80523
> email@example.com
> phone: 970-491-7003 fax: 970-491-1801
-- ----------- There are 3 types of people in the world. Those who can count and those who can't. -----------Received on Sat Apr 9 15:24:02 2005
This archive was generated by hypermail 2.1.8 : Sat Apr 09 2005 - 15:24:02 EDT


text: About Mixed Fruit Halwa Recipe: This recipe is something special for babies. Well, you know most of the babies are picky eaters. Several times they refuse to eat. My little one is almost the same. He too doesn't eat properly. But yesterday I saw my 10 months old having his meal happily after long time….


text:
Yesterday we talked about my favorite Lean tool, Y to X trees. If you haven't read it yet, go check it out. We'll wait.
OK, welcome back. Today we are going to talk about one of the foundational principles of operational management, fixed costs versus variable costs. They are the two components you will find when breaking down your costs, be they production, sales, marketing or HR.
Fixed costs are the ball and chain of the business world. You will pay these costs week to week, month to month, year to year. They do not change based on your level of activity.
One of the most traditional examples of a fixed cost is rent of your office space. You will pay that cost according to your lease even if you have no business operations that month. Conversely, you'll generally pay that same amount if you are running at 200% capacity.
Office equipment is another fine example. Your lease costs for laptops, printers, desks and the like aren't likely to change month to month, regardless of how often they are used. That's not to be confused with consumable materials, such as paper or toner for your printer. Those would be considered…
Variable Costs
These are costs that will change based on your level of activity (or some other business variable).
In the manufacturing world, variable costs are often tied to the number of widgets produced. If your factory is creating a physical product, there is some level of raw material used. If we assume $1 of steel is needed to make a $2 widget, then I'll need $100 of material for 100 items, $200 for 200 items, and so on. Your cost will vary based on activity level, but is still predictable based on your business plans.
Another variable cost is labor. Let's assume I employ 10 hourly workers at $10 per hour, 40 hours per week each. My simple cost of labor is $4,000 per week. And at capacity, they produce 1,000 widgets. My material cost is $1,000, bringing my operation cost to $5,000 that week. Simplified, of course.
But if my orders increase, now we pay overtime. For 2,000 items to be produced, I double my cost of materials. And I need my team to work 80 hours this week at overtime rates of $15 per hour over 40. Material is now $2,000, labor is now $4,000 for the first 40 hours, plus $6,000 for the second 40, bringing cost of operation to $12,000. My output has doubled, but my costs have increased even more based on the change in production level. My lease on the factory, though, will have remained the same.
Fixed vs Variable Costs in HR
These are simple concepts, at least at this level. The application can become complex, but the point here is to try to identify the difference.
HR, of course, has both types of cost as well. A few examples:
Fixed costs: equipment lease, exempt salaries, ATS contract rates
Variable costs: job postings, applicant materials, travel
There are plenty of other examples of course. Tomorrow, we will take a look at how these two costs can be combined with our Y to X tree to start identifying action plans from strategic goals.


text:
In order to become a US citizen, immigrants must pass the Naturalization Test. American citizenship bestows the right to vote, improves the likelihood of family members living in other countries to come and live in the US, gives eligibility for federal jobs, and can be a way to demonstrate loyalty to the US. Applicants must get 6 answers out of 10 in an oral exam to pass the test. According to US Citizenship and Immigration services, 92 percent of applicants pass this test.
You must get 58 or more of these test questions correct in order to pass.
the Secretary of State
the Chief Justice of the Supreme Court
the Vice President
the President
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text:
Eclipse Day Florence 2013
More info on www.eclipsedayflorence.com
This edition is dedicated to anyone who wants to share with the community their success in the adoption of Eclipse technologies or, more generally, the Open Source technologies.
Main topics addressed:
- Eclipse Technologies
- Model Driven Development
- Test Driven Development
- Continuous Integration
- Cloud
- Mobile
- OSGi
Call for Papers closed
The Call for Papers has been closed on February 20th.
Thanks a lot to everyone who has submitted a session proposal !
By the end of February, the technical committee will communicate the proposals accepted and the first talks will be published.
Sponsoring Packages
Support a great free event while making qualified contacts with Italian participants!
We have various packages available to sponsor the Eclipse Day. All sponsorship will be used to fund the day and make the event free for the participants.
If you want more information about sponsorship opportunities, please send an email to email@example.com.


text:
infoniche needed a new print or packaging design and created a contest on 99designs.
A winner was selected from 112 designs submitted by 37 freelance designers.
Need a striking and eye-catching design (front and back) for a DVD about our Solar System.
The video is full of breathtaking photographs from NASA spacecraft, and the cover should reflect the content.
This DVD is the first in a series. Therefore, there should be one or more elements that can be repeated on subsequent volumes to establish continuity. This could be the font style and first part of the title, or it could be something more than that. It's up to you.
The video itself has a lot of photographs of our Solar System's planets and moons. It uses Adobe's Trajan Pro typeface for internal titling and captions. You don't have to use Trajan necessarily -- this is just to point out that for the cover, a font that's excessively modern probably won't work.
The title of the video is "What You Aren't Being Told About Astronomy, Volume I: Our Created Solar System".
We've uploaded some images you might consider using. They're at http://www.creationastronomy.com/art.
Note: one of the files provided (Columbia_Moon.jpg) should not be
included as-is on the front cover. It would be too similar to the cover of
another DVD already on the market. If you can find a different use for
it (or pieces of it), that would be OK.
If you find other images you want to use, please make sure they are public domain, and that we can verify this. We're willing to buy stock
photography or images if they're necessary (and inexpensive), but since
most NASA images are public domain, hopefully this won't be
If you have a specific idea that would require an image you can't find, post a request and we'll try to find it for you. We know the NASA image databases pretty well. Please do your best to describe exactly what you're looking for. (Example: I want a photo of the Moon, looking across dramatic terrain, and taken from a low altitude above the Moon's surface looking out toward space, with the horizon at a 45 degree angle going up from left to right.) Or, if you want a higher-resolution version of an image you've already found, point us to the URL of the lower-res version. However, either way there's obviously no guarantee that we'll be able to find what you want.
Also at http://www.creationastronomy.com/art, you'll find:
- a headshot of the author (headshot.tif)
- the copy for the back cover (backcover.txt).
The dimensions for the final design are 3236 pixels wide by 2173 high. This includes a spine in the middle (165 pixels wide). The cover will be printed at 300 dpi. (For interim mockups, lower resolutions are fine, of course.)
We might ask for minor revisions after the contest ends. (In particular, a physicist is currently reviewing this video, and his comments will be inserted into the back cover copy if they're brief and received in time.)
Final delivery will be as a PNG, along with the layered project file. If you can supply an Adobe InDesign INDD file (version 2.0 and above), that would be ideal. Otherwise, a PSD will work too.
If you wish to submit a front cover design first for feedback before spending time on a matching spine and back, that would be fine. We're happy to give guidance on the front cover first, as long as enough time remains for a proper treatment of the back and spine too.
- Clean and elegant design. It should communicate the beauty, awe, and grandeur of the planets in our Solar System.
- A too-futuristic or science fiction look.
- Artwork about far-away planets orbiting other stars.
- Too large of an emphasis on galaxies, nebulae, or stars. Using them as background is OK (if it's done subtly). But the focal point of the design should have something to do with planets, moons, and/or our Sun.


text:
More Than 100 Students Suspended For "B*tch A$$" Video in TN
HICKMAN COUNTY, Tenn.- More than 100 Hickman High School students were suspended after a YouTube video of students swearing was discovered by school administrators. "That Sh*t Cray" -@AllAboutJones
Please click the "Report" button below if the video on this page is not working properly.
Comments will only be displayed by verified emails. No Spamming or Racism.


text:
BETHESDA, Md. - Tues., Oct. 10, 2006 - The Foundation for the National Institutes of Health (FNIH) today announced that six major studies of common diseases have been selected as the first to undergo whole genome analysis by the Genetic Association Information Network (GAIN).
This type of analysis is designed to identify the genetic contributions to common illnesses that affect the public health, such as depression and diabetes. Using biological samples already collected in earlier clinical studies, GAIN will comprehensively evaluate the subtle differences between the genomes of approximately 1,000 - 2,000 normal, healthy volunteers and the genomes of 1,000 - 2,000 patients with the condition being studied. Identifying genetic differences between the two groups will speed up the development of new methods to prevent, diagnose, treat and even cure common conditions.
The Genetic Association Information Network is a unique public-private partnership involving the National Institutes of Health (NIH), Pfizer, Inc., of New York City, Affymetrix, Inc., of Santa Clara, Calif., and the FNIH, as well as Perlegen Sciences, Inc., of Mountain View, Calif., Abbott, of Abbott Park, Ill., and the Broad Institute of Massachusetts Institute of Technology and Harvard University in Cambridge, Mass.. GAIN was established in February, 2006 to help find the genetic causes of common diseases by conducting large-scale genomic studies and making their results broadly available to researchers worldwide. Private donors have contributed approximately $26 million to the project in order to stimulate rapid progress in this field. Companies funding this partnership, however, will not receive any special benefits from GAIN, such as advanced access to the data.
"Public-private partnerships like GAIN bring new scientific and financial resources to the NIH's existing whole genome association programs, accelerating our progress in this important new field of research," said Dr. Charles Sanders, Chairman of the Board of the FNIH. "We're extremely pleased with both the rapid progress of the program and the quality of this first round of studies."
The FNIH Board of Directors selected the first six studies after rigorous peer, technical and ethical reviews and at the recommendation of the GAIN Steering Committee, comprised of twenty-one distinguished scientific leaders from government, academia, and industry. The successful studies, with their principal investigators and affiliated medical institutions, are:
The studies were chosen out of nearly three dozen applicants during a rigorous fivemonth selection process. A unique feature was the involvement of a Technical Analysis Group (TAG) that provided a secondary level of evaluation beyond the peer review of written applications. The TAG, which consisted of experts in genetics, epidemiology, bioethics, and data analysis, pre-tested the DNA in study samples, analyzed multiple informed consents, checked case/control matching, and carefully evaluated the study populations of the top-ranked applications that passed peer review.
"GAIN is a critical first step in identifying the genetic factors that influence disease susceptibility and health, and it is essential to choose studies that offer the best possible potential to find these factors in common diseases," said Francis S. Collins, M.D., Ph.D., director of the National Human Genome Research Institute at NIH and chairman of the GAIN Steering Committee. "I'm extremely pleased that GAIN will also be making the results from such high-quality studies in these very important diseases easily available to all researchers."
GAIN will pay for analyzing approximately 18,000 samples across the six diseases, using genotyping services provided by Perlegen Sciences (in partnership with Pfizer) and the Broad Institute (in partnership with Affymetrix) over the next four to eight months. Genotyping uses standardized laboratory procedures to identify genetic variations between individuals. By comparing the frequency of genetic variants across all of the chromosomes in both affected and unaffected persons, researchers can pinpoint hereditary factors that contribute to illness.
As DNA samples from each study are genotyped, the results will be made broadly available to the research community in keeping with the principles pioneered by the Human Genome Project. A portion of the $5 million provided by Pfizer to pay for the overhead of the GAIN project will support development of the GAIN database by The National Center for Biotechnology Information (NCBI), a part of the National Library of Medicine at NIH.
"Immediate, broad release of the scientific data generated by GAIN, with appropriate protections for the privacy of patient data, is critical if we are going to truly facilitate the discovery of new molecular targets for prevention, diagnosis, and treatment," said GAIN Steering Committee member Patrice Milos, Ph.D., Executive Director of Molecular Profiling at Pfizer Global Research and Development, Groton, Conn. "Pfizer is delighted to be a partner with NIH and FNIH in delivering world-class science and in making these data available in a timely way to help the research community and, ultimately, patients."
In addition to free genotyping of their samples, the primary investigators for each of the chosen studies and their institutions will receive additional grants from NIH to support analysis of the new genetic data. For example, a special funding program for type 1 diabetes research established by Congress is contributing support for the study on diabetic nephropathy.
FNIH will also hold a GAIN Analysis Workshop for the selected investigators and their data analysts, as well as known experts in the design and analysis of genetic studies, in the Washington, D.C., area on November 29-30, 2006. The meeting will be open to the entire scientific community.
It is expected that FNIH will seek additional funds beyond those already provided by Pfizer and Abbott to support additional genotyping studies under GAIN.
The National Institutes of Health (NIH), the nation's medical research agency, includes 27 institutes and centers and is a component of the U. S. Department of Health and Human Services. Institutes that are participating in this round of GAIN include the National Human Genome Research Institute, National Institute of Mental Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, and the National Center for Biotechnology Information. NIH is the primary federal agency for conducting and supporting basic, clinical, and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
The Foundation for the National Institutes of Health is a nonprofit organization authorized by Congress to raise private funds and establish public-private partnerships to support the NIH mission. More information about FNIH can be found at www.fnih.org.
Pfizer Global Research & Development is the world's largest privately owned biomedical research organization. Pfizer Inc discovers, develops, manufactures and markets leading prescription medicines, for humans and animals, and many of the world's best-known consumer brands. More information about Pfizer can be found at www.pfizer.com.
Affymetrix Inc. (Nasdaq:AFFX) scientists invented the world's first high-density microarray in 1989 and began selling the first commercial microarray in 1994. The microarray technology is used by the world's top pharmaceutical, diagnostic and biotechnology companies, as well as leading academic, government and not-forprofit research institutes. More information about Affymetrix can be found at www.affymetrix.com.
Perlegen Sciences, Inc. is a biopharmaceutical company developing genetically targeted medicines. The company has built one of the world's leading genetic analysis capabilities and believes that genetically targeted medicines hold the promise of significantly improving patient care in a wide range of therapeutic areas. The company works with major pharmaceutical companies in a broad range of disease and drug response areas and has begun building its own drug development pipeline. More information about the company can be found by visiting Perlegen's website at www.perlegen.com.
Abbott is a global, broad-based health care company devoted to the discovery, development, manufacture and marketing of pharmaceuticals and medical products, including nutritionals, devices and diagnostics. The company employs 65,000 people and markets its products in more than 130 countries.
The Broad Institute of MIT and Harvard was founded in 2003 to bring the power of genomics to biomedicine. It pursues this mission by empowering creative scientists to construct new and robust tools for genomic medicine, to make them accessible to the global scientific community, and to apply them to the understanding and treatment of disease. The Institute is a research collaboration that involves faculty, professional staff and students from throughout the MIT and Harvard academic and medical communities. It is jointly governed by the two universities. For further information about the Broad Institute, go to www.broad.mit.edu.
Editor's Note: The FNIH and GAIN Partners will hold a press conference to announce the GAIN awards on Tuesday afternoon, Oct, 10, 2006, at the American Society of Human Genetics annual meeting in New Orleans. The press conference will be held at 3 p.m. Eastern Time (2 p.m. Central Time) in Room 346 of the Ernest N. Morial Convention Center, 900 Convention Center Blvd., New Orleans. Reporters may listen to the press conference by teleconference: USA Toll Free Number: 877-931-3478 or USA Toll Number: 210-515-1631; Passcode: 738275.
Editor's Note: Perlegen closed operations on October 30, 2009.
Geoff Spencer
(301) 402-0911
Charles Pucie
(301) 435-6248
Kate Robins
Last Reviewed: February 8, 2010


text:
Originally posted on 3/25/09 in Cenantua's Blog:
How many folks actually realize how many "galvanized Yankees" there really were? They're a fascinating bunch of people, really. Up until a few years ago, I didn't really think a great deal about them. I might see one here or there while combing through Confederate service records, but I never got up the energy to really investigate until about four years ago. It's a tough bunch of guys to figure out in terms of loyalties. How many, for example, signed-on to the United States Volunteers simply because they felt their odds far better than stuck in a prisoner-of-war camp and how many signed-on because their loyalties were really with the U.S. to begin with? Then, on top of this, when we realize that a "galvanized Yankee" received a pension, does it mean that he REALLY was a Unionist? Think about it. On one hand, you have someone who has to go through a lot of hoops to get a pension for his service in the Union army. To satisfy a very discriminating pension board, the former Confederate soldier had to prove to the board that his service was really involuntary. If one could not show that they did not "bear arms against the United States voluntarily," the pension application was going to be rejected. On the other hand, if someone was hard-up for some money, "swallowing the dog" one more time to get some cash to help make ends meet wasn't all that bad. Like I said, they are a hard group to get your thoughts around when trying to get a grip on wartime sentiments/loyalties, but a fascinating group nonetheless. (Incidentally, this is a good online piece by Michèle T. Butts about how "Galvanized Yankees" came to be).
On that note… looking for a quick distraction from thesis work late Monday night, I slipped over into my Footnote.com account and started doing a few searches. Looking back through my wife's family tree, I remembered that she had an ancestor who "joined the U.S. service" after just over two years of service in gray… and quite honestly… surprise, surprise… he was from an area in Alabama that just happened to have some differences in sentiment.
Hiram Fikes was born February 15, 1827 in Lexington, South Carolina, a son of John Fikes. A farmer by occupation, he didn't enlist for the first time until April 10, 1862 (this was, by the way, around the time the first Confederate conscription act was being enforced; although there is nothing to show one way or the other how/if this impacted Fikes' enlistment/enrollment), and when he did enlist it was only in a 90-day unit; the 4th Alabama Volunteer Militia (Byrd's Regiment), Captain John Moore's Company. He was sick-in-quarters 6/25/62 and had no further record with the unit. Nonetheless, he pops up again on the rolls of Co. H, 40th Alabama having enlisted (or having been "enrolled") in Perry Co., Alabama (that is where he resided at the opening of the war) in March 1863. There is some confusion as to how the regiment was employed around the time of his service; one part detailed for service in Georgia, while the other part was in Vicksburg. It looks like Hiram was in the Vicksburg detachment for it is there that he was captured by the 15th Corps and was paroled on 7/9/63. Returning to service, once again, he was with the 40th Alabama again when he was captured at Big Shanty, Ga. on 6/15/64. This time the Federals didn't mess around, and he was sent to Rock Island, Illinois by way of Louisville, Ky. In four months, he was released on oath, having signed-on with Co. I, 3rd United States Volunteers.
Looking at his service cards for this unit, it appears that Hiram was an average looking fellow, with blue eyes, dark hair, light complexion, and 5'6″. He was mustered-in on October 31, 1864, and… this part always interests me (former Confederates being credited to areas to satisfy enrollment numbers)… he was credited as a recruit to Elk, Clarion County, Pennsylvania. The 3rd USV more or less hung out at Rock Island for sometime before being sent out to the Dakota Territory in 1865. While there, it appears, at least from his service records, that his service went without incident. In May 1865, he was listed as on daily duty as the company cook (hard-pressed, I'm sure, as a Southerner on duty in the Dakota Territory finding foodstuff that would be satisfying to a Southerner!). He was detached at the Sweet Water detachment on June 4. Soon after this (July 1865), fourteen men from Co. I got into a scrape with the Sioux and Cheyenne heading east to Fort Laramie, but I have no idea if Fikes was among the fourteen men (my guess is that he wasn't). Other than the detached service at the Sweet Water detachment, there really isn't a great deal to note from his service records until he was mustered-out at Ft. Leavenworth, Kansas on November 29, 1865 (although he did have a stoppage of pay for damaging the property of another member of the unit… don't ask, I have no idea what that was all about). He headed back to Mississippi and there, rejoined his wife Polly and their children. He applied for a pension (oh now, hold on a second… a pension for his service in the Union, not the Confederate army) on August 18, 1892 (application #1126.495) under "Law J" and received one (certificate #1069.626). He died on October 20, 1903 in Fulton, Itawamba County, Mississippi and was buried in the Harden Chapel Cemetery. His wife applied for a widow's pension (app. #797.144) on December 31, 1903, and received one (cert. #744.318). She died on February 20, 1925.
I don't see him as a disaffected Confederate, but perhaps a disillusioned Confederate. Likewise, he probably wasn't a Southern Unionist in the extreme sense, but maybe he was a conditional Unionist who opted for the Confederacy initially. Yet, as he saw the writing on the wall, especially as a POW, maybe, at heart, he was just a realistic self-preservationist, looking at things in terms of his own best interests and that of his wife and children who were back in Alabama when all of these decisions were made. It's clear that I need to look into the pension record and see what the testimonials have to say about his "loyalties" and how he got around the "not having borne arms voluntarily against the United States" thing.


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Protect Your Identity While Shopping
Posted On: December 12, 2018 | By: Stream Marketing
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This National Fraud Awareness Week, Fight Cybercrime Yourself
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Puzzling Wood Gift Box
Give the Gift of Frustration
- Wooden gift box that is also a puzzle
- Warning: Impatient giftees will break it open
- Gift not included, use it as creatively as you'd like!
"A box without hinges, key, or lid, Yet golden treasure inside is hid."
- Bilbo Baggins
If you want something good sometimes you need to work for it. Look at your ungrateful friends and relatives. You give them nice gifts and get a half-hearted "thank you" with no true appreciation for the time you took from your busy gaming schedule to visit a physical store and select something. Finally with this gift box you can give a gift and gain evil vicarious enjoyment for yourself. This devious box of delight can be used to store a small gift, then you can give it to your unsuspecting giftee and watch the fun begin. With no obvious opening, latch, or moving parts your gift recipient will struggle in frustration as they are dominated by the task of opening a simple wooden box.
This gift box is not the same as those Chinese puzzle boxes you may have seen before with multiple sliding parts you push in a certain order. It features a simple mechanism that's a snap to open if you know how, but really frustrating when you don't. Try as you might to slide all the edges and corners of this box... nothing seems to move. No instructions of any kind are included so you'll need to figure out how to open it beforehand and insert your gift... and we at ThinkGeek don't plan to tell you how to do that. That is our special gift to you.
Product Features
- Small wooden box has seemingly no way to open it and can store a small gift
- Box comes empty. You provide the gift
- Difficult to open... unless you know how
- No instructions are included
- Small box measures 12 cm x 9 cm x 4.5cm. Interior area for storing your gift measures 9 cm x 5 cm x .63cm (Fits Jewelry or Cash.)
- Large box measures 15.0 cm x 8.5 cm x 5.3 cm. Has TWO compartments.- 9.2 cm x 4.7 cm x 2.2 cm and 5.3 cm x 2.8 cm x 2.2 cm


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Monday 9:40AM 7/9/12
Pork product continues to work its way lower as July 4th business is finished. Last week we lost a rather large $5.30 on wholesale pork and the previous week we lost $5.38 on product. This two week decline of over $10.00 is about as big a decline as we ever see. The problem at the present time is a fairly current producer inventory of market ready hogs. This is keeping the current cash hog market from having much of a selloff, and with product sharply lower the last several weeks, pork packer operating margins are over $22.00/head negative and at record losses. Last year, at this time, pork packer operating margins were a positive $3.33/hd..
Traders are fully aware of the 2-3 weeks pork product selloff that takes place after July 4th business has been completed and this was the single biggest reason for August hog futures to close 145 points lower for the week. The present problem going forward is that August futures have a rather large 736 point discount to the lean-hog-index (100.66) and this is keeping traders from wanting to seriously attack the short side of August. With a tight near term supply of market ready hogs it is going to be tough to take a lot out of the cash hog market over the next several weeks. This will probably keep the present downside correction to no more than 250-400 points. In addition, hog weights are staying on the light side as extreme summer heat is limiting weight gains.
Spread trades will be the biggest focus this week as corn continues higher on lack of moisture. Most traders will be buying December and back hog futures against selling August as feed costs escalate. There will some additional selling of August against buying of July as July went home last Friday with a 444 points discount to the lean index and this must narrow by Julys last trading day next Monday.
If you are short August futures below 9475 you should look to take profits somewhere in the 9100-9350 area. Unless we see a good break in the cash hog market we will not be able to get a sizeable break in the lean-hog-index and with August futures at the present 736 point discount there could be little on the down side this week. Spread pressure may keep August on the defensive, but a two week wholesale pork product break of over $10.00 may see near term product weakness decline.
At this time do not turn an August profit into a loss.
We have priced wholesale beef out of retailer interest. Choice boxed beef was $1.13 lower Friday and down $2.01 for the week against being $0.59 higher for this week last year. Select boxed beef was a large $3.38 lower for the week being $1.91 higher last year.
The biggest thing that shows beef business is seasonally slowing is daily/ weekly volume. U.S.D.A. date for Friday morning showed wholesale beef loads were the lightest of the year at 74 loads and weekly total boxed beef volume of 797 loads was over 14% less than the previous week, 25% less than last year and 30% less than this same week in 2010.
Small volumes of cash cattle traded $1.00 higher for the week with Southern Plains at $117.00 and Nebraska carcass at $186.00-$188.00. As of 2PM Friday there were no cash cattle sales in Nebraska. Most traders believe beef packers are finding near term feedlot market ready cattle to be tight as excessive heat has limited weight gains and in many cases is finding cattle losing weight the last few weeks. There is constant talk of feedlots moving light weight cattle to market as corn prices go over $7.00 per bushel, but that does not appear to be the case last week.
Like hog futures, we will see a lot of traders buying December and back futures against selling August/October this week as long as corn continues higher. August is a easy short side of these spreads as July is never a good demand month for beef (heat brings less outdoor grilling) and back month cattle futures are an easy buy as traders thing less cattle will be placed into feedlots in the coming months as corn continues marching higher.
We wanted to add a second short unit to August shorts we have been in from the 118.00-119.50 area, but cash cattle trading an unexpected $1.00 higher last week will keep this on the back burner for the moment.
You should liquidate this trade should August cattle futures trade over 122.62 for more than two hours.
Substantial risk of loss in trading futures and options. Past performance is not indicative of future results. The information and data in this report were obtained from sources considered reliable. Their accuracy or completeness is not guaranteed and the giving of the same is not to be deemed as an offer or solicitation on our part with respect to the sale or purchase of any securities or commodities. PFGBEST, its officers and directors may in the normal course of business have positions, which may or may not agree with the opinions expressed in this report. Any decision to purchase or sell as a result of the opinions expressed in this report will be the full responsibility of the person authoriz
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Graduation caps hard road for one determined cadet
New London - The first time Joshua Surgeon's Coast Guard career nearly ended was Aug. 1, 2009.
At home in Portland, Ore., after his freshman year at the Coast Guard Academy, Surgeon went with his family to Lake Billy Chinook, as he had many times in the past.
Surgeon and a relative were on two personal watercraft when he pulled ahead. The nose of the other watercraft crashed into his right leg, pinning it. He remembers looking down at his shattered tibia and thinking the Coast Guard would never let him become an officer, and his life would be sedentary.
The next eight years had been planned out - three until graduation, then five serving in the Coast Guard.
Surgeon was an athlete who wrestled for the academy, but doctors said he would walk with a limp and would never run again. They inserted a titanium rod and screws into his leg. After the operation, Surgeon's leg was battered, but straight.
"I knew I would be able to walk," he said recently. "If I could walk, I could slowly jog. If I could jog, I could skip or wobble to a mediocre run."
Surgeon fought an infection in his leg and returned to the academy against the advice of his parents, who wanted him to take a medical leave. It took nine months of often painful rehabilitation to break up scar tissue and prevent the tibia and fibula from fusing together.
Surgeon not only ran again, he ran a marathon. He returned to competitive sports and won the National Collegiate Boxing Association championships in the 165-pound weight class last month.
On Wednesday, the 23-year-old will graduate in the academy's Class of 2013 and become an ensign in the Coast Guard.
"I can tell you, without exception, Josh is the most determined guy I have ever coached in all my years at the academy," said Tom Barile, who has worked with three national champions in the 12 years he's been head coach of the boxing team. "When he sets his mind to something, it will be done."
But Surgeon would need to tap into that ability again when, in 2010, his future as an officer was in jeopardy for a second time.
Only three months after the accident, Surgeon, still walking with a cane, approached Barile and said, "I want to box."
Hundreds of cadets have told him that over the years, Barile said recently. Nine out of 10 changed their minds after the first workout or the first punch to the nose.
Surgeon had no boxing experience. His leg muscles had atrophied after months on crutches. At one point, his arm circumference was larger than that of his lower leg.
He wanted to compete again as a wrestler but worried his leg would twist in the wrong direction during a match. His high marks on the academy's physical fitness test in January 2010 gave him the confidence to box.
But Surgeon was awkward in the ring because his skills from wrestling didn't translate to boxing. He was told he had no footwork, he didn't move well. The workouts were so tiring that he couldn't lift his hands high enough to cover his face.
"You can never make excuses for yourself, because then your own standards will drop," Surgeon said.
He learned how to strategize in the ring. And he worked out, a lot. At 5 feet, 7 inches, Surgeon is always shorter than his opponents in his weight class, but he's more muscular.
Finally, he was ready to compete in his first bout. Then, in November 2010, Surgeon was dismissed from the academy.
Surgeon was accused of attempted theft after he found an iPod in the barracks over the summer and didn't turn it in.
He said he knew who owned it and planned to return it when that cadet got back from a summer assignment. But he admitted to using the iPod as a timer.
Surgeon went home briefly, then returned to Connecticut to try to earn a second chance, even though the academy rarely re-admits a student who violates the school's honor code.
He lived on his own and juggled a full schedule at Eastern Connecticut State University, a full-time job as a personal trainer and gymnastics coach, and volunteer work.
He reflected on the meaning of honor through a lengthy self-assessment program at the academy for cadets who commit honor offenses, and he sparred with the boxing team to help prepare the newer boxers for their bouts.
In short, Surgeon "found every opportunity to shine," Lt j.g. Gabriel Nelson said.
"It was remarkable to watch. It took an insane amount of energy and dedication to do that, and that's one reason I really admire the guy so much," said Nelson, an upper-class cadet at the time who was a friend and mentor to Surgeon.
Surgeon re-applied and was allowed to return to the academy in August 2011.
"Knowing how great of a service this is always let me have enough courage to try, to try again, to not stay down," Surgeon said. "With the leg injury, that was disappointing and devastating because that was completely out of my control, really. It was more or less how my body was going to react to the physical therapy. But the honor incident, that was totally in my control. … Knowing that, I took a chance to try to come back."
Surgeon got his "never-quit attitude" from his father. Rick Surgeon also was in a serious accident as a young man when, at the age of 19, he swerved his car to avoid a truck and crashed into oncoming traffic. He fell so far behind in college that he withdrew.
Soon after, he applied for a job at the Union Pacific Railroad in Portland. His neighbor recently had been hired, but he was told there were no openings.
He visited the office each week for about two months until he was offered a job. That experience taught him never to take no for an answer, and he often tells his four children they shouldn't, either. Of all his children, he said, Joshua is the one who has taken that lesson to heart.
"When I stop to think about it," Rick Surgeon said, "tears come to my eyes because I'm so happy and so proud of him."
Each time Josh Surgeon went for a run or hit a bag to train for this year's National Collegiate Boxing Association Championships, he thought about how he felt losing the title in the 2012 competition in a controversial, split 3-2 decision.
Nelson, who boxed at the academy, said coming so close can be crushing.
"It makes me think about his character, his story," he said. "It's this constant story of getting knocked down and coming back up a lot stronger the second time."
Before this season started, a runner who had signed up for the Marine Corps Marathon in Washington, D.C., but couldn't go gave Surgeon his bib number. Surgeon ran his first marathon in under 3½ hours.
Back at the academy, Surgeon boxed instead of going out on Friday nights. He has a week of leave but he spent it training.
Surgeon won the Western New England Golden Gloves Championship in his weight class in January. At the 2013 NCBA Championship Finals at Foxwoods Resort Casino the first weekend of April, Surgeon was not the most skilled boxer in the tournament, but he was the most determined, according to Barile, his coach.
In the finals, Surgeon won a unanimous decision against an Air Force cadet, giving the academy its first championship belt since 2009. He was named an All-American for the second time and finished his amateur boxing career with 20 wins and three losses.
Surgeon said the watercraft accident nearly four years ago was "a blessing in disguise" because he likely never would have boxed if he could have kept on wrestling, and he never would have learned so much about himself.
"I was injured and what I thought my identity was, was now terminated. I was not going to be a wrestler and potentially, I was not going to be a military member in the Coast Guard," he said. "Labeling yourself as one thing is a really bad way to look at life. You have a lot more self-worth and meaning with what you do, and not necessarily what you call yourself."
The Coast Guard does not have a boxing team Surgeon can join once he graduates, but the Navy's team is open to Coast Guard boxers and coincidentally, it's in San Diego, where Surgeon will be stationed on the Cutter Sherman.
Surgeon is excited for his new life as a Coast Guard officer and as a potential member of the All-Navy Boxing Team. But he probably won't label himself that way.
Surgeon now thinks of himself in terms of his best features - his sense of humor, his easygoing nature, his compassion for others, and most of all, his perseverance.
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1. The Music Slut leads the pack, of course, with:
A) New Ry Ry video, entitled "Follow the Lights." Ain't half bad either. It really sounds like Ry is getting his groove back on. "There was never anywhere to go / but home." (Home is apparently where Donna lives.)
B) The Who on Jools Holland. Completely unironically singing "hope I die / before I get old." Psh, I knew they were lyin'. Generation X salutes you, baby boomers! Sic transit gloria mundi, except when you can capitalize on your nostalgia. Oh well, the music is still hawt.
C) Cold War Kids in the Black Cab. I can never decide if I'm totally in love with CWK, or whether they're just totally pretentious. I call this the Decemberists Dilemma. Haha. The violin on this song is just stunning.
D) PJ Harvey on Leno, circa 93. This is the PJ I was talking about a couple days ago. That quick slip between begging her lover not to leave, to talking about tying him up till he wishes he'd never heard of her.
E) Bjork Unplugged, 1993, "One Day" acoustic. TOTALLY AWESOME.
F) The Cure in Amsterdam, "the Forest," 1980. Robert Smith, pre-persona. Twelve years later, this song rocked my world, I'm not even kidding. Oh Robert, I miss the days when you weren't a caricature of yourself.
G) Tori on The Current, doing Leather. Oh Tori, I miss the days … well, whatever.
2) Via LAist, an amusing misheard lyrics video, featuring one of my favorite workout songs: Sean Paul's "Temperature."
3) Via Stereogum, a fun video for Bishop Allen's "Click Click Click Click."
4) At Fabulist, Olga takes us back to the early days of Rilo Kiley with "The Frug."
5) Via Skatterbrain, some good old fashioned pop from Lykke Li: "Little Bit." Feel free to chair dance.
6) Muzzle of Bees revisits last years's #3 awesome album. "So how do you feel about being dead?" "I don't know … my neck hurts." I LOVE YOU BLACK KEYS.
7) Since Bodies of Water and Stereogum are BFFS, you can see clips there from BoW's "Takeaway Shows."
8) Awesome vid from *my* new BFF, LoveLikeFire: "I
Will." (via Rock Insider).
9) ECEU finds one of my fave James Taylor songs, You Can Close Your Eyes, It's Alright.
10) LAist notes that KT Tunstall turned up to support the WGA a couple weeks ago and someone took a video of her doing "I Want You Back".
11) Idolator puts the spotlight on Melissa Auf der Maur's "Followed the Wave." *sigh* She's so beautiful. If Foo Fighters had a girl twin, Auf der Maur would be it.
12) Via Electroqueer, Roisin Murphy at the Swarovski fashion awards doing "Overpowered." I love that hair!
13) IGIF brings us back to the 10 year old video for UNKLE & Thom Yorke's "Rabbit In Your Headlights," which I had never seen, though I love the song. What a creepy video, but perfect for the song.
14) And last but not least, new Postmarks video via Stereogum. "Let Go," all hazy and sunny and green, showcasing one of the best songs on a great album.


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