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There are no Upcoming Shows listed for this comedian.
Craig Baldo
The summer of 2007, I landed an internship with Wieden and Kennedy in Portland, Oregon where I wrote my first TV and print ads for NIKE. While in the Pacific Northwest, I booked Bumbershoot in Seattle opening six shows for Janeane Garofalo. Six months later, a few weeks into my first full-time job as a copywriter for Kirshenbaum, Bond and Partners in NYC, I taped my debut stand-up appearance on Late Night with Conan O'Brien. The focus thing was working- writing began to fuel my stand-up and vice versa. At KBP, I went on to create "3conomics" for Wendy's, which became their Value Menu campaign during the early days of the recession, and was awarded a Golden Bagel by the agency for Campaign of the Year. Soon after, I was featured prominently in New York Magazine as one of "Ten New Comedians that Funny People Find Funny." That Fall, after "leaving" KB where I had penned over 20 TV and radio spots for Wendy's, most of them airing nationally, I jumped into a Hybrid car for a month and drove cross-country, writing and producing a Ford Motor Company sponsored comedy project for J. Walter Thompson. Since I've had stints writing freelance for Euro RSCG and Grey.
Craig Baldo's Upcoming Shows
Craig Baldo is Known For
|Premium Blend
|Stand-Up Show
|Late Night w/ Conan O'Brien
|Talk Show

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Boss Orange Oflash Coat Medium Brown 50390628
98% cotton. 2% elastane
Fully lined
Machine wash
We now use Business Post for the majority of UK Delivery and sometimes Royal Mail Special Delivery and orders received by 3.00pm are usually dispatched that day for delivery the following day. Although we offer a next day delivery service, some remote areas may take 48hrs and we can not be held responsible for delayed orders or unforseen delays by the courier.
UK Delivery
UK Mainland buyers should receive your order within 3 days depending on the time the order is placed (excluding Bank Holidays) UK Mainland Orders on Fridays can be delivered on Saturday by request Northern Ireland orders are 3-5days or next day delivery depending on option chosen at checkout UK mainland orders are FREE Northern Ireland costs differ and certain areas of the UK are not guaranteed next day delivery
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We ship to Europe using Business Post Courier and delivery aim is within 3-7 working days.
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Yes we ship all over the world (for ?9.99), but we will only ship outside the UK to cardholders name & address, we will not ship to a different address to that of the cardholder. Your shipping costs will be displayed at checkout for the country you live in. International shipping is sent with either Royal Mail, Parcelforce or Business Post depending on the weight & desitination of your order.
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open Monday - Saturday 01652-654585 or by emailling us at email@example.com
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Kennedi Boutique
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North Lincolnshire
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Items can be exchanged for another size, subject to availability.You can exchange an item for
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everything and initiates your exchange orderaccording to your wishes.
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Return postage is at your expense. You are strongly recommended to keep the receipt of postage.
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However if there has been a mistake with your order for which we are responsible we will refund the
cost of returning the item up to the amount indicated on the proof of delivery.
Kennedi Boutique will assume the cost of sending the new exchange order.


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Brain Anatomy Revealed With CLARITY
Quick Links
Adapted from a story that originally appeared on the Schizophrenia Research Forum.
10 April 2013. A method for examining the detailed structures of the intact brain with light microscopy debuts in a paper coming out April 11 in Nature. Called CLARITY, and developed by Karl Deisseroth and colleagues at Stanford University, Palo Alto, California, the technique washes away the fatty cell membranes of neurons while leaving in place the rest of the cell's parts, including proteins and nucleic acids. This rendered intact mouse brains transparent and permeable, which allowed an unobstructed look at neurons and their processes with no need for sectioning or reconstruction. The technique also worked with human postmortem samples preserved for years in fixative, and thus could help reveal an integrated view of brain organization in disorders such as Alzheimer's disease and schizophrenia. The advance made the homepage of The New York Times.
Until now, the brain has given up the details of its organization one thin slice at a time. Because light from microscopes cannot penetrate very far into the brain before getting refracted by the lipid bilayers of cell membranes, researchers cut the brain into slices tens of microns thin. These slices also expose components of the cell so that they can be labeled with markers, such as fluorescent antibodies. After generating images of each slice, researchers then reconstruct portions of the intact brain by realigning the images.
The new technique circumvents this painstaking process. Recognizing that lipid bilayers both scatter light and interfere with access to cell components, the researchers got rid of the membranes while preserving structure with a stand-in scaffolding onto which cellular constituents were chemically tethered. This left behind a porous, yet fully assembled system of cell parts, amenable to imaging and labeling of different cellular molecules. Though other intact-imaging techniques have extended the depth of light microscopy (e.g., Hama et al., 2011), they do not offer a preparation permeable enough for labeling.
Call it CLARITY
First author Kwanghun Chung and colleagues began by perfusing mouse brains with a mixture of formaldehyde and hydrogel monomers. Formaldehyde, a traditional fixation chemical, links molecules together to preserve tissue structure. In this preparation, formaldehyde molecules linked cell parts such as proteins or nucleic acids to the hydrogel monomers, which then polymerized to form a lattice-like mesh. This provided a scaffold upon which cell parts were firmly linked when the lipid bilayers were removed. A specially designed chamber applied an electric field across the brain to expedite the lipid exit, leaving behind a transparent brain. In all, the process took about eight days.
The researchers examined the brain of an adult mouse expressing a fluorescent protein in a subset of projection neurons. In a 3.4 mm cube of tissue, the microscope revealed the axonal pathways traversing the brain, a layer of cortical neurons with their dendrites stretching above them, and at higher magnification, the spines along these dendrites. There did not seem to be any loss of resolution deeper into the sample, so structures of the brainstem, thalamus, hippocampus, and cortex were equally visible.
Multiple Rounds of Molecular Phenotyping
Because this transparent brain is also permeable, the researchers labeled different cell parts, a process they called "molecular phenotyping." CLARITY degraded significantly less protein than conventional methods of clearing tissue. Indeed, immunohistochemical labeling identified tyrosine hydroxylase (TH), a key enzyme for making catecholamines such as dopamine, throughout the cleared brain, including in deep regions such as the ventral tegmental area and dorsal raphe nucleus. To reach into the depths of an intact brain, however, required a six-week-long incubation and wash process—significantly longer than immunohistochemistry with sectioned tissue.
Three-dimensional view of intact hippocampal tissue block showing enhanced yellow fluorescent protein-expressing neurons (green), parvalbumin-positive neurons (red), and glial fibrillary acidic protein GFAP (blue). Image courtesy of Kwanghun Chung and Karl Deisseroth
Labeling for an assortment of other molecules worked, too, and this was expedited by cutting the intact brain into a 500-micron block. Three days of immunolabeling for synapsin, a presynaptic marker, and PSD-95, a postsynaptic marker, revealed individual excitatory synaptic contacts. The researchers also labeled small non-protein molecules such as γ-aminobutyric acid and messenger RNA. The researchers also found that the CLARITY-treated brain could withstand multiple rounds of labeling. For example, one round of TH-labeling, followed by washing it away, followed by another round of TH-labeling, produced identical patterns of TH signal.
Immunohistological visualization and identification of neurons and projections in postmortem tissue. Image courtesy of Kwanghun Chung and Karl Deisseroth
Take It to the Brain Banks
The researchers also found that CLARITY worked with precious human brain samples already in storage. They cut a 500-micron-thick slice from a postmortem frontal lobe sample from a person with autism that had been stored for over six years in formalin, and treated it with the CLARITY procedure. After staining with antibodies, the researchers could visualize and trace individual axons. By staining for parvalbumin, a protein in certain kinds of inhibitory neurons that are suspected of contributing to imbalances in excitatory and inhibitory signaling in autism and schizophrenia (see SRF related news story), they visualize these neurons embedded within the cortex, along with the full extent of their processes. Curiously, some of these processes formed ladder-like "dendritic bridges," either by reconnecting with themselves or with processes from other neurons. A postmortem sample from a control brain did not reveal as many of these ladders.—Michele Solis
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Paper Citations
- Hama H, Kurokawa H, Kawano H, Ando R, Shimogori T, Noda H, Fukami K, Sakaue-Sawano A, Miyawaki A. Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain. Nat Neurosci. 2011 Nov;14(11):1481-8. PubMed.
Other Citations
External Citations
Further Reading
Primary Papers
- Chung K, Wallace J, Kim SY, Kalyanasundaram S, Andalman AS, Davidson TJ, Mirzabekov JJ, Zalocusky KA, Mattis J, Denisin AK, Pak S, Bernstein H, Ramakrishnan C, Grosenick L, Gradinaru V, Deisseroth K. Structural and molecular interrogation of intact biological systems. Nature. 2013 Apr 10; PubMed.
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Hi, I'm a 5.0 male looking for players for practice hitting and matches. Please contact me if you're interested (male or female). Thanks.
Views: 560
Replies to This Discussion
There's tennis court in my neighborhood w/ lights if u willing to drive.
thanks, Lindsey. I'm not far from the Galleria area. What level of tennis would you say you play?
i would say 4.0-4.5. haven't hit in a couple of months, so it'll take me a couple of days of hitting or so to get back to a solid 4.5.
Hey Benjamin,
I am new to the Houston area and I am about a 4.5-5.0 player. I live just north of memorial park and I want to find someone to hit with. Let me know if you are interested, contact me at email@example.com
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Scuderia Ferrari pencil case with stationery set
This 3-zip pencil case comes packed with a complete stationery set. It is made from polyester with mesh inserts and has distinctive personalisation on both the front and back.
The front of this Scuderia Ferrari pencil case is inspired by the nose on F1 cars and is embellished with mesh inserts, the print and the Scudetto Ferrari logo in enamelled metal. The back of the pencil case is customised with a print featuring the single-seater car and personalised metal zip pullers. The pencil case is divided into three sections and contains: 1 blue Frixion erasable pen, 18 Giotto coloured felt tip markers, 18 Giotto colouring pencils, 1 Lyra graphite pencil, 1 red pen, 1 Fila highlighter, 1 pencil sharpener, 1 rubber, a 15 cm ruler, 1 protractor, 1 set square and 1 pair of round-tipped scissors.
- Zip
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- Canvas
- Composition: 100% Polyester


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The 9 Key Pieces For Mastering Classic Style
Here at Who What Wear headquarters, we shop for sport. And since half the fun is sharing our spoils, we'd like to present a new weekly roundup of clothing and accessories that our editors are craving now. Today's topic? The nine pieces that every classic lady should have in her wardrobe. Click through to see our picks!
J. Crew Collection Cashmere Topcoat ($1800)
?The camel coat will never go out of style, trust us.
J. Crew Claremont Mini Purse ($148)
?A classic outfit wouldn't be complete without a sharp bag in a timeless shape.
J. Crew Linen Popover ($80)
?If we look half as good as this J.Crew model in this striped popover top, you can bet we're clicking "add to cart."
J. Crew Collection Wool Silk Scalloped Pant ($298)
?We'd take these flattering trousers in just about any colour.
J. Crew Brass and Crystal Petal Necklace ($95)
?Wear this rhinestone and gold necklace for a special occasion, or just when you're feeling fancy.
J. Crew Schoolboy Blazer In Tipped Linen ($185)
?The contrast trim on this schoolboy blazer makes it a standout from the preppy pack.
J. Crew Colorblock Crepe Top ($98)
?Anyone up for a game of tennis? This sport-chic top would be right at home on the court.
J. Crew Everly Suede Pumps ($245)
?We're getting colour happy just looking at these bubble-gum pink pumps.
J.Crew Sunburst Skirt ($118)
?This peach skirt is pleated perfection.


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(Credit: Purdue University photo/Andrew DeWoody)
Frogs just can't catch a break. First there was pollution, then amphibian chytrid fungus, then global warming. And now: road kill.
A Purdue University inventory of road kill during a 17-month period on a particular Indiana road tallies the body count:
- 79 opossums, the most common mammal;
- 36 chimney swifts, most common bird;
- 35 common garter snakes, most common reptile;
- 43 raccoons;
- 4 white-tailed deer;
- 9,300 amphibians
This is according to a new, Science Daily news release that says 95 percent of the road kill was frogs and toads and salamanders. Here's an excerpt:
The dead included 142 road-killed eastern tiger salamanders, a finding DeWoody said was troubling.
"The absolute number might not look that large, but most of these individuals were mature, up to 10 years old," DeWoody said. "Many of them were gravid, or females bearing eggs on an annual trip to breeding grounds where they often lay 500 to 1,000 eggs. This could make a potentially big difference for the population."


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4807 Posts
quote:Originally posted by Beans15Obviously not if you are a Leaf fan. I guess you want a limited amount of really young, gifted talent with loads of potential to avoid the problem of having to sign all that talent. I guess it's better to trade off all of your draft picks for a single player because it's far easier to keep that one guys and let your competition reap the benefits of not only your draft picks but their own as well.Yep, smart hockey management at it's finest.
PickupHockey Pro
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8286 Posts
quote:Originally posted by Guest9052Beans, Boston already used the 2nd round pick they got from the Leafs last draft.Draft season with only 29 picks?? are you refering to the devils pick?T-RAV
Mario 66
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360 Posts
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PickupHockey Veteran
2312 Posts
quote:Originally posted by ToXXiK1Well, back to the topic:Looks like Savvy's season, if not career could be over. He took quite a nasty hit against the glass with his face, courtesy of one of our own that we traded to Colorado, Matt Hunwick.Testing will happen today, but, the history is getting long with Savvy and he might just have to make some hard decisions.Minimum of him sitting to after the All Star break."Hockey is a man's game. The team with the most real men wins. - Brian Burke
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75 Posts
PickupHockey Pro
991 Posts
quote:Originally posted by T-RAVI personally hope that Savard has the same type of career that Lindros had.
quote:Originally posted by T-RAVI personally hope that Savard has the same type of career that Lindros had.And ya. I have no doubt that Seguin is going to be good. But there is no guarantee that he wont be injured or will turn out to be the best player on your team either.And the same goes for Kessel for us.I am not commenting on anyone else's post. Just a thought of my own. I would like to see Boston win the NE Div. and lose in the first round to the Habs.Peace and Respect
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quote:Originally posted by slozoHa ha, funny stuff . . . especially considering that Rask never played one game fro Toronto, as he constantly mentions whenever interviewed about this crap. He was traded as a prospect, and good for him - he has flourished.Oh, and to get back on topic: the Bruins are going to be just fine unfortunately, they will finish well ahead of Montreal, and the meltdown is currently happening RIGHT NOW (for the Habs)."Take off, eh?" - Bob and Doug
PickupHockey Pro
350 Posts
quote:Originally posted by ToXXiK1Yep, just checked and, there IS a Montreal thread..........."Hockey is a man's game. The team with the most real men wins. - Brian Burke
quote:Originally posted by ToXXiK1So true, thank you for pointing that out, but I can't find a Leaf paragraph in this thread?. Now, just found this, just as expected:http://tsn.ca/nhl/story/?id=350909Now that Savard is sidelined, maybe, just maybe Julien gives Seguin more than 8 minutes a game now that a centre spot is open?"Hockey is a man's game. The team with the most real men wins. - Brian Burke
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Monday, December 6, 2010
Rag Stockings
When I told my husband that I wanted to make our stockings, his only request was that they be BIG! So BIG they are! :) (better for stuffing!) I made the first three stockings six years ago, when we only had our baby Rachel. From the get-go I decided to make them all different so that I wouldn't have the stress of buying enough fabric, or having a surprise child later on, and having to do a stocking that didn't match- so I eliminated that problem by just making them as the kids come! I love our stockings- and I especially love how you can tell how the styles of fabric have changed over only a few years! :) Mine is the not-so-cute red and green, my husbands favorite color is blue, so that is his, then it goes in order from our oldest daughter to our two younger boys.
I have saved the pattern so that with each kid I just have to make a new one. They are so fast, simple, and inexpensive to make.
If you would like a pattern, I will send it to you for $3 (to cover paper and shipping costs) I will cut it out of sturdy cardstock and I will mark the joining seams, and include basic instructions. Happy Holidays!!!
7 comments:
- Jennifer said...
I would love the pattern for those! They are super cute. How do I go about getting money to you to order? My email is email@example.com
- December 7, 2010 at 7:26 AM
- MaryBerry Boutique said...
So Cute! I made my own Stockings as well:) I think it makes them more personal and you can make them any color and as BIG as you like! Im going to have to make that sign! I NEVER have a place to hang my stockings and i think this is the ticket:)
Merry Christmas:)
- December 7, 2010 at 7:34 AM
- Jenny said...
I love these!
- December 7, 2010 at 8:15 AM
- Stef said...
Your Stockings are awesome!
- December 8, 2010 at 10:31 AM
- Stacey said...
I love these. Please stop by and link up to my Christmas stocking linky party this weekend!
- December 15, 2010 at 12:50 AM
- I♥naptime w/ Chocolate Sundaes said...
This turned out SO cute!! goodjob!
- December 19, 2010 at 6:52 AM
- Heather said...
Do you still have the pattern for this? How could I get one? My e-mail is email@example.com. Thanks!
- November 27, 2012 at 8:04 AM
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What Is Psoriatic Arthritis?
About 15 percent of people with psoriasis will develop psoriatic arthritis.
Psoriatic arthritis is a form of psoriasis that affects the joints.
Like psoriasis, psoriatic arthritis is an autoimmune disorder, in which your body's immune system attacks healthy cells and tissues.
In psoriatic arthritis, the immune system targets the joints, leading to inflammation and pain.
Risk Factors
While the exact cause of psoriatic arthritis is not known, some risk factors may include:
Psoriasis: Those with psoriasis, particularly in cases where it affects the nails, are more likely to have psoriatic arthritis.
Approximately 15 percent of those with psoriasis develop psoriatic arthritis.
Heredity: Forty percent of those with psoriatic arthritis have a parent or sibling with psoriatic arthritis.
Infection: Psoriatic arthritis may be triggered by a viral or bacterial infection that sets off your immune system.
Age: Being between 30- to 50-years old places you in a higher-risk age group.
In some cases, however, psoriatic arthritis will begin in childhood.
Psoriatic arthritis is a chronic disease that has periods of remission and flare-ups that will get worse over time.
The main symptoms of psoriatic arthritis are:
- Joints that are painful, swollen, and warm to the touch
- Swollen fingers and toes, a condition called dactylitis
- Foot pain, especially a condition called enthesitis, in which you'll have pain where tendons and ligaments attach to bones, particularly at the heel or sole of your foot
- Pain in the neck, lower back, or with bending
At your appointment, your doctor will examine you for swollen and painful joints, nails that are flaking or pitting, and check the soles of your feet for any swelling or tenderness.
Your doctor may order an X-ray, MRI, or CT scan to check for joint damage.
Also, your doctor may order some additional tests to evaluate you for rheumatoid arthritis, osteoarthritis, gout, or other conditions.
No cure for psoriatic arthritis exists, but there are ways to manage the inflammation and pain.
The most common drug treatment options are:
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Disease-modifying antirheumatic drugs (DMARDs)
- Immunosuppressants
- TNF-alpha inhibitor
- Steroid injections
Complications of Psoriatic Arthritis
The most common side effects of psoriatic arthritis are anemia, fatigue, and depression.
You may also experience high blood pressure, high cholesterol, diabetes, or weight-control problems.
A more severe complication is arthritis mutilans, a condition that attacks the small bones in your fingers and hands and causes permanent disability.
Fortunately, only a small percentage of those with psoriatic arthritis will develop arthritis mutilans.
- Diseases and Conditions: Psoriatic Arthritis (Mayo Clinic).
- Psoriatic Arthritis (American College of Rheumatology).
Last Updated: 4/27/2015


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wu-tang clan
MK Keeps Wu-Tang Close For New Projects
- 2006-07-27 01:15:40
© The Wu-Tang Corp.
- 2006-07-27
With his sophomore solo set, "Made in Brooklyn," due for an Aug. 8 release via Nature Sounds, Wu-Tang Clan rapper Masta Killa will also appear on upcoming projects with Wu colleagues Method Man ("4:21: The Day After"), Inspectah Deck (a new mixtape) and Raekwon (the highly anticipated sequel to his 1995 debut, "Only Built 4 Cuban Linx").
"Everybody who has an album coming out, Im there," Masta Killa tells Billboard.com. "The foundation of my music is family oriented so without my supporting cast it wouldnt be what it is. The only thing that really keeps us separated is that were all pulled in so many different directions. Im fortunate that Im in a situation where I can be patient enough to be creative."
Aside from guest turns by the entire Wu-Tang Clan, "Made in Brooklyn" sports production from MF Doom, Pete Rock and PF Cuttin. Its the follow-up to 2004s "No Said Date."
"Having the opportunity to work with producers and other emcees from my hood -- East New York, Brooklyn -- was definitely something I wanted to do for a long time," says Masta Killa. "No Said Date was a pretty good pot of stew. From the chefs position, I was told not to change too many ingredients [and] just give the same dish again, so I tried to stay consistent with that."
With so many internal collaborations underway, the rapper says a new Wu-Tang studio album is continuously in the works. "Were definitely in the midst of building it," he says. "Its nothing really to work out. Its just saying, "This is what were ready to do" and also "This is what we have time to do." Were always recording so at any time we could say, "Lets put this array of songs together." Also up in the air is the status of late member Ol Dirty Bastards posthumous "A Son Unique," which was supposed to be out last year.
As previously reported, Wu-Tang will regroup next month for several shows, dubbed the
Tribute to ODB tour
, beginning Aug. 3 in Phoenix. "Im looking forward to that. Its a chance for a lot of the hip-hop fans that have been waiting to see Wu-Tang as a family [to see] all eight members on stage," says Masta Killa. "Even for us not having been onstage together for a long time, its a good feeling and we want to bring that energy to our fans."
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GZA Earns The 1st Platinum Album For The Clan In 20 Years
Proof, that the Wu-Tang Clan ain't nothing to mess with
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For over 30 years the leading pallet and sawmill magazine in America.
Read What's Related:
Proposed Food Safety Rules Concern Pallet Industry
Food Safety and Modernization Act: Industry members are concerned that food safety regulations could result in significant new costs to supply chain.
By DeAnna Stephens Baker
Date Posted: 11/1/2013
Following many delays, the Food and Drug Administration (FDA) is making progress toward releasing final rules for the Food Safety and Modernization Act (FSMA) that was signed into law in 2011.
The purpose of FSMA is to ensure the U.S. food supply is safe by shifting the focus from responding to contamination to preventing it, which also puts a focus on practices along the entire food supply chain.
Although there is little mention about pallets directly in the legislation, some of the wording in a proposed rule is concerning for the pallet industry. The National Wooden Pallet and Container Association (NWPCA) has prepared comments on the proposed Standards for the Growing, Harvesting, Packing and Holding of Produce for Human Consumption (produce rule) that outline the association's concerns.
"Our industry's biggest concern with regard to the Food Safety Modernization Act (FSMA) is related to language that leaves open to interpretation whether or not a pallet is to be 'clean' or 'sanitized' as 'appropriate," said Brent McClendon, president and chief executive officer. "Within the Act, clean is defined as 'no debris, soil, blood, oil, leaves' similar to voluntary standards in practice today. Sanitized is defined as a treatment method that 'uses heat or chemicals to effectively reduce 99.9% of pathogens.'"
NWPCA supports a clean-use standard and believes the vagueness of the wording in the FSMA will cause inconsistent regulatory enforcement and confusion throughout the food supply chain.
"We urge clarity in the use of a sanitized standard," said McClendon. "For example, a food grower who has a demonstrated record of non-compliance with a 'clean' standard that has resulted in food contamination might be held to the higher 'sanitized' standard. A sanitized standard across the entire food distribution system, however, would build in substantial new costs to the food supply that would have a severe negative impact on consumers."
Thanks to the Tylenol recalls in 2009 and 2010, wooden pallets have been linked in the public's mind to food contamination issues in general and to the FSMA. Anti-wood campaigns have described wooden pallets as breeding grounds for bacteria that expose any food product transported on them to chemicals and contamination. However, in its comments, the NWPCA explains how wood is used in and around food and has been for centuries without ill effects.
"Wood is a natural product that has been used safely in the food industry for centuries," said McClendon. "Wood has not only evidenced it is a safe, efficient, cost-effective material for pallets, crates and containers used to transport food, but also as an actual component of some food products. Consider for example, the wood sticks used in ice cream bars and popsicles. The wood used is strong, smooth and absent of flavor that might compete with the delicate taste of the frozen food bar...The history and ongoing use of wood as an actual component in food products such as ice cream bars, popsicles and corndogs and as a food utensil, demonstrates it is a sanitary material for use in the food and pharmaceutical industries."
The FSMA rule promulgating process has been a slow one, with the FDA missing the original Congress-mandated deadline of July 2012 to complete the rules. This summer, after several public interest groups challenged the FDA's delay in issuing regulations, a federal court ordered the FDA to publish the remaining proposed FSMA regulations for comment by November 30, 2013; have all public comments submitted by March 31, 2014; and publish final rules by June 30, 2015.
The FDA will be accepting public comments on the proposed produce rule until November 15, 2013. Comments can be submitted online at http://www.regulations.gov under docket number FDA-2011-N-0921.


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Mobile development
Бюджет $250-750 USD
아이폰/아이패드 앱 아이폰만 디자인 안은 이미 가지고 있습니다 Xcode8 Ffmpeg use crop and time cut
22 фрилансеров(-а) в среднем готовы выполнить эту работу за $604
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Dec 20, 2010
Free Printable 2 Digital Paper 12x12
Free Printable 2 Digital Paper 12x12 in high quality 300 DPI from my last paper pack "Love In Paris", Great for scrapbooking, making cards, tags and invitations. This pack contains 20 digital paper for $2. To see another sample click here.
You can Download the papres.
For Personal Use Only.
Password: sherykdesigns.com
DownloadTotal Download:
12 comments:
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A dynamic fusion of design and substance2 slices toaster with a painted stainless steel body shrouded in a sculpted resin
Download the Breakfast Collections Augmented Reality App to see products come to life in your kitchen.
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© De'Longhi Appliances S.r.l. - Via L. Seitz, 47, 31100 Treviso, Italy - All rights reserved


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ROLLING STONESstreet fighting man +2Label: DECCA 13195Format: 45Grade: M-Category: RARE Rock & PopNotes: Italy, PS (very sl cw), w/ Surprise Surprise/Everybody Needs Somebody To Love, disc nearly new!Price: $40
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We package and ship our vinyl records with the greatest care, using extra-thick packaging to ensure that your rare and collectible vinyl records arrive in pristine condition.
We guarantee every item we sell to be as listed. We endeavor to provide superior service, but if we make an error, we'll make every effort to make it right either by refunding all costs involved, or adjusting the selling price to everyone's satisfaction.
Double LPs, box sets, etc. will incur additional shipping costs as indicated above, please edit your shipping total appropriately when submitting payment through PayPal. After completing your transaction, please await your email invoice before submitting payment. Your invoice should arrive within 3 hours.
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reference number, speed (LP/45), Artist, Title, Label, Label #, Condition,
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COMMENTS Comments have no bearing on the disc itself, but only refer to the cover or
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Words & Photos: Matt Gormley
The upscale boutique evo hosted yet another extravaganza Friday night in Seattle, premiering the video How the Northwest was One from Wildcard films. The evo team linked up with mad scientists from Spacecraft and a crew from Stevens Pass to throw yet another top-notch preseason bash. The Senate Arcade played live and Pyramid Brewery served up cold suds. What more could you want?
The Spacecraft art installation outside evo bled into the gallery that included sculpture, paintings and stickers galore. Stevens Pass forked out free lift tickets at the door, teasing riders with reports of fresh snow on the hill and The Senate Arcade strummed, hummed and drummed before the flick. The lights dimmed… It was on.
The video opens with a fantastic Kayne West spoof and a heartfelt tribute in memory of Sean "Donkey" Mansfield. Donkey's fate over the summer still stings in the hearts of his extended family of friends.
Wildcard lit up the screen with a literal wild card selection of riders. In a season with shrinking budgets and limited dollars, the crew created a collaborative and dynamic film using a "Stone Soup" approach. Manuel Diaz, Andy Stern and Joe Bosler all offer breakout video parts. Veteran rippers Tim Carlson and Kurt Jenson continue to tear the Cascades year after year. Nitro ruler Shaun McKay stole the show with his epic all mountain assault. The result is a flick worth way more than the sum of its parts.
The standing room only crowd obviously dug the flick. As Joe Bosler closes out the film with a stomped double cork 900 to fakie, the room is silent for a second before erupting into applause. Great place to end it. Nice work Wild Card.


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Gene transfer represents a relatively new possibility for the treatment of rare genetic disorders and common multifactorial diseases by changing the expression of a person's genes. Typically gene transfer involves using a vector such as a virus to deliver a therapeutic gene to the appropriate target cells. The technique, which is still in its infancy and is not yet available outside clinical trials, was originally envisaged as a treatment of monogenic disorders, but the majority of trials now involve the treatment of cancer, infectious diseases and vascular disease. Human gene transfer raises several important ethical issues, in particular the potential use of genetic therapies for genetic enhancement and the potential impact of germline gene transfer on future generations.
Gene transfer can be targeted to somatic (body) or germ (egg and sperm) cells. In somatic gene transfer the recipient's genome is changed, but the change is not passed on to the next generation. In germline gene transfer, the parents' egg and sperm cells are changed with the goal of passing on the changes to their offspring. Germline gene transfer is not being actively investigated, at least in larger animals and humans, although a great deal of discussion is being conducted about its value and desirability.
Many people falsely assume that germline gene transfer is already routine. For example, news reports of parents selecting a genetically tested egg for implantation or choosing the sex of their unborn child may lead the public to think that gene transfer is occurring, when actually, in these cases, genetic information is being used for selection, with no cells being altered or changed. In addition, in 2001 scientists confirmed the birth of 30 genetically altered children whose mothers had undergone a procedure called ooplasmic transfer. In this process, doctors injected some of the contents of a healthy donor egg into an egg from a woman with infertility problems. The result was an egg with two types of mitochondria, cellular structures that contain a minuscule amount of DNA and that provide energy for the cell. The children born following this procedure thus have three genetic parents, since they carry DNA from the donor as well as the mother and father. Although the researchers announced this as the "first case of human germline genetic modification," the gene transfer was an inadvertent side effect of the infertility procedure.
Many factors have prevented researchers from developing successful gene transfer techniques in both somatic and germline attempts (the latter in animals). The first hurdle is the gene delivery tool. The new gene is inserted into the body through vehicles called vectors (gene carriers), which deliver therapeutic genes to the patients' cells. Currently, the most common vectors are viruses, which have evolved a mechanism to encapsulate and deliver their genes to human cells in a pathogenic manner. Scientists have tried to take advantage of the virus's biology and manipulate its genome to remove human disease-causing genes and insert therapeutic genes. However, viruses, while effective, introduce other problems to the body, such as toxicity, immune and inflammatory responses, and gene control and targeting issues. Complexes of DNA with lipids and proteins provide an alternative to viruses, and researchers are also experimenting with introducing a 47th (artificial human) chromosome to the body that would exist autonomously along side the standard 46 chromosomes, presumably not affecting their functioning or causing any mutations. An additional chromosome would be a large vector capable of carrying substantial amounts of genetic code, and it is anticipated that, because of its construction and autonomy, the body's immune systems would not attack it.
Some of the concerns raised about somatic gene transfer are related to the possibility that it could inadvertently lead to germline gene transfer. The possibility of germline modification through these techniques is the result of the hit-or-miss nature of the current technologies. It is always possible that a vector will introduce the gene into a cell other than that for which it is supposed to be targeted (e.g., a spermatocytic cell) or that through a secondary mechanism target cells that have taken up the new gene will through some independent natural process (such as transfection) transfer the gene to a germline cell. Moreover, if somatic gene transfer were to be conducted in utero, especially before the second trimester, it would increase the likelihood that some of the cells into which the gene is taken up will become part of the germline. It is possible that to effectively treat certain diseases using gene transfer, it might be necessary to apply somatic techniques early in development so that germline transfer is inevitable.
In contrast to inadvertent germline transfer following somatic gene transfer, intentional germline gene transfer would involve the deliberate introduction of new genetic material into either germ cells (sperm or oocytes) or into zygotes in vitro prior to fertilization or implantation. Currently, this technology has not been applied to humans; however, it has been successfully applied to some plants and animals. The aim of this process is to produce a developing embryo in which each cell (including those that will develop into gametes in the future) carries the newly inserted gene as part of its genetic make-up.
Current efforts in animals have demonstrated the difficulty of this approach. Some cells do not acquire the gene or acquire multiple or partial copies of the gene. In addition, it is not yet possible to specify with any accuracy where in the genome the new gene will be introduced, and some insertion locations may interfere with other important genes. If these kinds of errors are detected, then theoretically embryos with these defects could be "selected out." However, should germline gene transfer be attempted in humans, it is likely that not all errors introduced as a result of the gene transfer will be detected.
Currently, however, animal studies have shown that gene transfer approaches that involve the early embryo can be far more effective than somatic cell gene therapy methodologies used later in development, depending on the complexity of the trait that is being improved or eliminated. Embryo gene transfer affords the opportunity to transform most or all cells of the organism and thus overcome the inefficient transformation that plagues somatic cell gene transfer protocols. Gene transfer selects one relevant locus for a trait (when in fact there might be many interactive loci) and then attempts to improve the trait in isolation. This approach, while potentially more powerful and efficient than conventional breeding techniques, involves more uncertainty risks.
Thus, both kinds of studies - germline gene transfer at the gamete and zygote stages - have significant risks. In cases in which the gene has failed to be introduced or fails to be activated, the resulting child would likely be no worse off than he or she would have been without the attempted gene transfer. However, those with partial or multiple copies of a gene could be in significantly worse condition. The problems resulting from errors caused by the gene insertion could be severe - even lethal - or they might not be evident until well after the child has been born, perhaps even well into adulthood, when the errors could be passed on to future generations. For these reasons, given the limits of current technology, germline gene transfer has been considered ethically impermissible.
Beyond the medical risks to the potential child, a number of long-standing ethical concerns exist regarding the possible practice of germline gene transfer in both human and nonhuman cases. Such modifications in human beings raise the possibility that we are changing not merely a single individual but a host of future individuals as well, with potential for harm to occur to those individuals and perhaps to humanity as a whole. Concerns involve issues ranging from the autonomy of future individuals to distributive justice, fairness, and the application of these technologies to "enhancement" rather than treating disease. In germline gene transfer, the persons being affected by the procedure - those for whom the procedure is undertaken - do not yet exist. Thus, the potential beneficiaries are not in a position to consent to or refuse such a procedure.
Gene transfer clinical trials have a unique oversight process that is conducted by the National Institutes of Health (NIH) through the Recombinant DNA Advisory Committee (RAC) and the NIH Guidelines for Research Involving Recombinant DNA Molecules, and by the Food and Drug Administration (FDA) through regulation (including scientific review, regulatory research, testing, and compliance activities, including inspection and education). Of note, FDA regulations apply to all clinical gene transfer research, while NIH governs gene transfer research that is supported with NIH funds or that is conducted at or sponsored by institutions that receive funding for recombinant DNA research. Currently, the majority of somatic cell gene transfer research is subject to the NIH Guidelines; however RAC will not currently consider protocols using germline gene transfer.
In addition, NIH has added to its guidelines the following statement:
The RAC continues to explore the issues raised by the potential of in utero gene transfer clinical research. However, the RAC concludes that, at present, it is premature to undertake any in utero gene transfer clinical trial. Significant additional preclinical and clinical studies addressing vector transduction efficacy, biodistribution, and toxicity are required before a human in utero gene transfer protocol can proceed. In addition, a more thorough understanding of the development of human organ systems, such as the immune and nervous systems, is needed to better define the potential efficacy and risks of human in utero gene transfer. Prerequisites for considering any specific human in utero gene transfer procedure include an understanding of the pathophysiology of the candidate disease and a demonstrable advantage to the in utero approach. Once the above criteria are met, the RAC would be willing to consider well rationalized human in utero gene transfer clinical trials.
Prepared by Kathi E. Hanna, M.S., Ph.D., Science and Health Policy Consultant
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Last Reviewed: March 2006


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Montecados (Spanish Cookies)
"This is a Spanish cookie recipe that was given to me from my aunt who was from Spain. The cookies need to cook in a very slow oven as you do not want...
cinnamon, flour, shortening, sugar, +anise extract, +almond
Biscochos (Mexican Wedding Cookies) Recipe
shortening, sugar, flour, cinnamon, +anise seed, +brandy
Egg Free Chocolate Chip Pumpkin Cookies
"This is a wonderful recipe when there are no eggs in the house and you have to make cookies. They are a very moist cookie and freeze well."
cinnamon, flour, shortening, sugar, +baking soda, +semisweet chocolate chips, +vanilla extract
"This is a classic fried dessert bread of Mexico. They're great hot out of the fryer and rolled in cinnamon sugar."
cinnamon, shortening, flour, sugar, +baking powder, +salt, +water
Eggless Ginger Cookies
"A great eggless recipe."
cinnamon, flour, shortening, sugar, +baking soda, +molasses, +ginger
Date Filled Cookies Recipe
sugar, shortening, flour, cinnamon, +eggs, +vanilla extract, +club soda
Bem Cake Recipe
sugar, shortening, cinnamon, flour, +raisins, +nutmeg, +baking soda
Cinnamon Swirl Loaf
A perfect breakfast treat.
Genesee Valley Apple Crumb Pie (Ny State)
Upstate NY is known for its many varieties of apples. NY State cooks create wonderful meals with the local apples including this pie from The Finger Lake...
Egg Free Pumpkin Chocolate Chip Cookies
These are my signature cookies! I got the recipe from Allrecipes.com a couple of years ago, and it has been a favorite ever since! Don't let the egg free...
flour, cinnamon, shortening, sugar, +baking soda, +pumpkin puree, +semisweet chocolate chips, +vanilla extract
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Beauty Shopping: 7-Eleven Convenience Store
Orginally, 7-Eleven was established in the US in 1927. Now, it has become the major convenience store chain in many Asian markets. 7-Eleven stores open 24 hours a day, 7 days a week. If you know the history of 7-Eleven, these stores used to open from 7 a.m. to 11 p.m, thus the name 7-Eleven. However, they revolutionized the concept of convenience store by establishing 24-hour stores.
In Taiwan, the 7-Eleven stores provide services from foods and drinks to newspaper/magazines, office supplies, skincare/makeup products, photocopying/fax services, bill paying services, and delivery/pick-up services. I always like to pick up ready-to-eat food (something like TV dinner) like bento box or Japanese maki rolls for lunch while I shop for beauty magazines in the store.
The pictures shown are images of the beauty section in a random 7-eleven store in Taipei, Taiwan where you can find DHC, Maybelline, Burt's Bee, Mentholatum, Herbacin...etc. The stores are usually very tidy and clean, and the customer service is friendly. Given the limited store size, the beauty products do not come in a wide selection in terms of brand and color variety. And, as usual, the prices might be higher than what you can find at drugstores or retail chain stores. But all in all, the beauty merchandise is carefully selected to best suits the demands and tastes of local shoppers in a reasonable price range.
Do you also like to shop at convenience stores? Is there anything special about your local convenience stores?


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"Oh crap," I thought. "You've got to be kidding me."
I've mentioned before in some other posts that I get headaches and disorientation when I play first person shooters. I've had this problem dating back to the original Doom and Wolfenstein 3D, when the old conflict between what my eyes are seeing versus what my inner ear is telling my brain first reared its ugly head. For a long time I assumed that MMOs would cause me trouble as well, but once I started playing WoW I discovered that the only location that I had problems was in Shadowfang Keep, with it's tight twists and turns causing the camera to constantly zoom in and out. Rift, LOTRO, and AoC didn't cause me any trouble at all, so I didn't expect anything different from TOR.
I couldn't see anything obvious in what the game was doing that would cause me issues, so I decided to simply call it a night and go and sleep it off. The next morning, however, I didn't have any trouble with the game at all. I chalked it up to sinuses and kept playing without incident.
Still, if first person shooters give you problems, go slow on TOR before you're comfortable enough with pressing onward.
Another thing happened in those first five minutes in addition to the headache: I was invited to join a group.
I'm used to the occasional random grouping request from other MMOs, but usually you get your feet wet before you group up with someone. With TOR, however, the group requests came very frequently throughout my free period. I really haven't played enough to get a good feel for the game community, but at first glance TOR seems to foster a community that works together, which is a bit different than that found in WoW or LOTRO. AoC does encourage grouping because the quest lines have a sizable number of multi-group quests, but TOR appears to have this driven organically as opposed to being imposed artificially.
Now, the higher you level, that scenario might change, but this is based on the first 11-12 levels or so.
Like most MMOs, TOR has multi-player quests.*
What I found interesting was where those multi-player quests --called Heroic Quests-- lay in the spectrum on MMOs.
In one end you have the group quests in Age of Conan, which are impossible to solo at level. In fact, the L20-ish group quests for AoC are only solo-able once you get into the upper L40s. Yes, that's a 15-20 level difference, and believe me the difference is real.
Somewhere in the middle you'll find the leftover WoW group quests and the LOTRO group quests, where the group quest difficulty can vary from quest to quest. Some of Icecrown's quests you can solo with raid gear at level, but others are too difficult to achieve otherwise. As a rule of thumb, a L10 difference (at low level) or an L5 difference (at Wrath level and beyond) is sufficient for soloing.
TOR, on the other hand, had 2-player group quests in Ord Mandell that were doable only a level or two higher than the intended level, and if you take along a companion there's no trouble at all. My suspicion is that this will scale in difficulty the higher up in level you go, but I didn't get far enough into the story to find out.
Nevertheless, to an experienced MMO player the 2-man group quests in TOR are doable at level with a companion. Just make sure your companion stays upright, and don't merely try to out-DPS the enemy.
The toon creation options are much greater than that in WoW or LOTRO, but most of the toons I saw had a similar body build.
So what did I do? Create Redbeard, of course.
I didn't go whole hog and make my Smuggler obese, but he is definitely on the chunky side. He's also tall (like the Ghost of Redbeard from the Scooby-Doo episode, not me), and he's got that full red hair and a beard. If I tried to do that in WoW, the best I could come up with would be a Dwarf; not exactly what I had in mind, you know.
Still, my Smuggler really did stand out from the crowd.
I didn't get the try the female creation tools, but I've seen articles by Spinks on them already, so they sound a bit like what you find in Age of Conan. Not perfect, but better than WoW or LOTRO.
So, if in case you were wondering, I did try something different than the most common models out there.
*Yes, WoW still has some group quests around, mainly confined to the BC and Wrath zones. In Icecrown, for example, you can't complete the Loremaster achievement there by soloing as an L80 with quest greens/blues; there are too many group quests standing in your way. When I finished that achievement on Quintalan back in Wrath, he needed T9 gear and the Quel'Delar quest chain to solo some of those group quests.


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Lizz Schumer, class of 2008, will return to campus to read from her book, "Buffalo Steel," at 7 p.m. Monday, Nov. 25, in the third-floor loft of the Regina A. Quick Center for the Arts at St. Bonaventure University.
One of the central questions in the new novel: Are we the product of our environments, or are our environments skewed by the perspectives our experiences create?
Published by Black Rose Writing, "Buffalo Steel" is "a gripping, raw coming-of-age story for the reader who understands that we are never finished creating ourselves, even when we travel the world to do so."
The novel follows the tumultuous life of Mary Catherine, a suburban girl turned world traveler. In turns sad, bleakly frightening, sardonically funny and poignant, Buffalo Steel reads like a memoir of many individuals conglomerated into one exemplary story.
"I drew from elements of my own experience to create characters that are grippingly, devastatingly real," Schumer explains. "And I placed them within contexts I knew intimately, leading them through lives that were very much true for many people, and will be true for many readers, as well."
Schumer's book uses a series of lyrical stories connected by found text, historical anecdotes, and quotations to explore what it means to be part of a society by birth, assimilation or a combination of the two. Firmly grounded in the rust belt's historical and cultural context, Buffalo Steel leads readers from the Great Depression to the 2000's and back again, in an exploration of how a person is a product of a place, or how a place that shapes us affects our trajectory. "Who are we, when we strip away everything we've ever known?" Schumer asks. "Buffalo Steel is my attempt at an answer. I hope it challenges readers to discover their own church, their own home, and their own steel."
A graduate of St. Bonaventure's Jandoli School of Journalism and Mass Communication, Schumer is a writer, reporter and photographer who lives and works in Buffalo. A 2012 Pushcart Prize award nominee, her poetry and prose has published in many literary magazines, journals, online media and anthologies.
She is the former editor in chief of the Pitkin Review literary magazine, and works as the editor of the Springville Journal. Her journalistic credits include USA Weekend Magazine, Buffalo Spree, the Hamburg Sun, the Buffalo News NeXt, Business First, Auxiliary Magazine and others. She has also served as the publicity director for the Subversive Theatre Collective.
Her reading is free and open to the public, and refreshments will be served. Schumer will be available after the reading to sign copies of her book, which will be available for sale.
About the University: The nation's first Franciscan university, St. Bonaventure University cultivates graduates who are confident and creative communicators, collaborative leaders and team members, and innovative problem solvers who are respectful of themselves, others, and the diverse world around them. We are establishing pathways to internships, graduate schools and careers in the context of our renowned liberal arts tradition. Our students are becoming extraordinary.
Application forms, procedures and additional information
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For over 30 years the leading pallet and sawmill magazine in America.
Read What's Related:
Workplace Safety Analysis Key Questions
These key questions will help you identify unsafe conditions and practices in your company and can guide you toward creating a safety culture.
By Staff
Date Posted: 7/1/2014
Safety Analysis
A list of key questions to consider as you evaluate your safety culture and practices. These questions can help you identify trouble spots.
Evaluating your current safety culture starts with the right questions. The following is not an exhaustive list. But it is a good place to start when looking at your overall safety culture and common practices. Consider checking with a safety consultant or other expert to conduct a more thorough evaluation.
This list covers some common areas of concern for pallet and lumber companies. These questions will help identify some key areas that may have been overlooked.
1.) Who has the responsibility for developing and monitoring the safety and health program in your facility? Is this material written down and when was the last time it was updated?
2.) Are all the required employee posters and signs displayed in a prominent location where all employees are likely to see it? Are emergency phone numbers posted where they can be readily found?
3.) Are all occupational injury or illness, except minor injuries requiring only basic first aid, being recorded as required on the OSHA 200 log? Who is responsible for your record-keeping practices and is this person up to date on the latest requirements?
4.) What processes are in place to ensure that all new hires go through the appropriate level of safety training as mandated by state and OSHA regulations? Also, are employees trained on safety related to new equipment or duties as they arise?
5.) Are managers and supervisors carrying out their safety and health supervision, training, and enforcement responsibilities? Find out why not if things are being ignored.
6.) Are employees carrying out their safety and health compliance and reporting responsibilities? If the answer is no, see if company policies or unwritten practices discourage reporting in any way.
7.) What are safety meetings like at your company? How often are they held? What content is covered? How are records kept to verify who attends the meetings?
8.) If you hire workers who do not speak English, are important safety materials translated into the appropriate language? Is safety training conducted in the native language of workers?
9.) Is there a system for identifying and evaluating workplace hazards whenever new substances, processes, procedures or equipment are introduced into the workplace, and whenever the employer receives notification of a new or previously unrecognized hazard?
10.) Has your location conducted a noise audit to verify the noise levels and worked to mitigate noise exposure?
11.) What personnel protective equipment do your employees wear and is this enough to meet OSHA guidelines?
12.) What have you done to reduce danger of exposure to either very hot or cold temperatures?
13.) Do you have a safety committee consisting of both labor and managers? What are the duties and requirements for committee members? Are periodic inspections for safety and health scheduled and carried out by managers and supervisors, and the safety committee?
14.) What mechanisms are in place to allow any employee to identify or report workplace hazards?
15.) Are unsafe and unhealthful conditions and work practices corrected immediately, with the most hazardous exposures corrected first?
16.) Is there an accountability system for ensuring managers and supervisors carry out their safety and health supervision, training and enforcement responsibilities? How are managers rewarded or penalized for these responsibilities?
17.) When was the last time a full safety audit was conducted by a qualified person at your location? Are inspection records kept which identify unsafe conditions and practices?
18.) What is your process if a lost time incident occurs at your location? Are all required records kept?
19.) Does your reward system encourage or discourage reporting of hazards?
20.) Who is responsible for first aid at your location? Have these employees kept their certifications up-to-date?
21.) Are flammable materials or hazardous chemicals stored properly? Do you have all required Safety Data Sheets on file and hazard communication posted?
22.) What type of regular emergency and fire safety drills do you conduct? How frequently are these done?
23.) Are all machines properly guarded to manufacture specifications?
24.) Do employees follow lockout and tagout procedures when working on machines?
25.) Have fall hazards been identified and proper railings and protections been installed to reduce worker injury risk?
26.) Is there an accountability system for ensuring employees comply with safety and health rules and hazard/injury reporting responsibilities?
27.) How does your company handle wood dust concerns? What practices are followed to reduce the risk of an explosion or spark?
28.) Are supplies and tools stored in such a way to reduce trip hazards?


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(CNN) -- From the darkest brown to the pastiest white and every shade in between, humans display a tremendous variety of skin colors. Human skin color is directly linked to our survival as a species as we lost our fur and developed a need for protection from the sun, and then migrated into cloudier regions of the globe. Over the course of evolution, scientists argue, skin color was influenced, among other factors, by our need for healthy bones.
To begin to explain this, we turn to Nina Jablonski, professor of anthropology at Pennsylvania State University. She is a well-recognized researcher in primate evolution, and specifically the evolution of human skin, and she was the subject of a Science Seat on CNN Light Years.
The story of human skin color begins with our furry ancestors about 6 to 7 million years ago in Africa, the last time that humans and chimpanzees shared an ancestor. Jablonski says that these ancestors, called Australopithecus, still had ape-like body proportions: fairly long arms and relatively short legs.
"When we look at their skeletons in detail, it's pretty clear that they were not active runners," she said. "They could walk on two legs but they weren't running or striding purposefully across the savannah most of the time, they were sort of living lives that are much like those of chimpanzees: fairly close to the edge of the forest, sometimes going into trees for protection, and then walking for short distances in the open to forage."
By about 1.2 million years ago, humans ancestors had lost their fur and were able to sweat more efficiently to avoid overheating. The fossil record shows this in the species Homo ergaster, for example. During this time, individuals began to walk across the hot savannah, so there was a need for more internal body heat regulation.
Without fur, however, our skin was exposed to the strong equatorial sun. The skin pigment melanin, which is responsible for most of the color of our skin. Melanin is a terrific sunscreen, and darkly pigmented skin became a substitute for fur.
But as our ancestors migrated away from the Earth's equator, which has lots of UV exposure, it became less and less beneficial for those populations to have so much pigmentation as protection from the sun. Why? For answers, we must look at vitamin D.
"Vitamin D is produced at high levels in the skin when it is exposed to ultraviolet light from the sun," says Dr. Michael Holick, a professor of medicine, physiology and biophysics at Boston University Medical Center. He is a leader in vitamin D nutrition, and among countless other works, published the book "The Vitamin D Solution."
According to Holick, back in the 1930s to 1950s, it was thought that the main reason for skin pigmentation was to prevent having too much vitamin D being produced in the skin. Too much vitamin D leads to vitamin D intoxication, which can result in death. However, in the early 1980s, Holick and his colleagues published a paper that disproved that theory.
"It turns out that Mother Nature was quite clever, in that any excessive exposure to sunlight destroys any excess vitamin D produced in the skin," Holick explained.
Vitamin D is produced in skin that's exposed to the sun, and it's involved in helping the intestines absorb calcium, which is a critical nutrient in our bones. However, heavily pigmented skin reduces a person's ability to produce vitamin D in the skin "probably by 90-95 percent," according to Holick, meaning they were more likely to be deficient in the vitamin.
As our ancestors migrated to areas away from the equator, with lower UV radiation, pigmentation became a problem. For example, Holick explained, a person from Africa who is very darkly pigmented has a sun protection factor of around 30. That person would have to be out in the sun at least 10 to 15 times longer to produce the same amount of vitamin D as a lightly-pigmented person from Europe.
Vitamin D is critical for healthy bones, which have always been essential to human survival. Not only are healthy bones important to movement and holding our bodies upright, but they are essential for reproduction. A pregnant mother who is vitamin D deficient can have a baby born with infantile rickets syndrome, a disease that leads to severe bone abnormalities. If the mother remains vitamin D deficient, she is also calcium-deficient. If breast milk is the main food source for the infant, the infant will not receive enough calcium to build healthy bones.
The female infant "will have a flat, deformed pelvis with a small pelvic outlet, making child delivery impossible," Holick said.
While rickets may not have affected male reproductive abilities as much, it would have given them weaker, more brittle bones, increasing their risk of fracture, and therefore affecting their ability to survive.
Vitamin D deficiency is associated with a host of other health problems, such as preeclampsia, asthma, upper respiratory infections in children, and even multiple sclerosis, Holick said. This is because of the vitamin's role in immune function, as it is thought to decrease risk of developing autoimmune diseases.
On the other hand, scientists know that too much sun can deplete a person's reserve of folate, a B-vitamin that is necessary for cell division and repair and known to reduce risk of fetal birth defects. A big source of folate comes from leafy green vegetables, but Holick argues that our hunter-gatherer ancestors would have eaten plenty of those. Today, many people do not eat enough of them.
So how much sun do modern humans actually need? Dr. Holick says that it's not possible to give an absolute recommendation because of the time of day, latitude and skin pigmentation, which all influence vitamin D production.
"For example, a lightly pigmented person in Boston in June at noontime, 10 to 15 minutes of sun exposure between the hours of 10 AM and 3 PM on arms, legs and abdomen and back when appropriate 2 to 3 times a week is usually sufficient," Holick said.
Now that most humans in modern society spend most of their days indoors, away from sunlight, you might assume that humans will eventually become homogeneous in terms of skin color and may lose darker pigmentation.
But Jablonski offers a different explanation for why human skin color will become more homogenous:
"Because of human migrations, especially in the world's largest cities, skin color will become somewhat more homogeneous because of increased admixture of people, while depopulated rural areas will tend to remain much as they are."
She emphasizes that that increased color homogeneity will result as a product of the intermingling of populations, not natural selection.
"There is no significant evolution acting on people who are either 'too light' or 'too dark' for their solar conditions because we have layers of protection in the form of complex culture, like buildings, clothing and diet," she asserted.
Any city-dwelling person, regardless of skin color, can become vitamin D deficient if he or she doesn't receive enough sun exposure. As Jablonski explained, just as lighter-skinned people are more likely to suffer from sunburn and therefore skin cancer, darker-skinned people experience more vitamin D deficiency because short periods of outdoor exposure aren't sufficient to allow them to produce enough vitamin D in the skin.
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Blaine Gabbert was at it again Friday, throwing extensively during practice in hopes of suiting up for Sunday's season opener against the Kansas City Chiefs.
The Jacksonville Jaguars quarterback "looked fine" Friday after practicing on a limited basis Wednesday and Thursday, but he looms as questionable for Week 1 with the thumb injury he suffered during the preseason, according to the Jaguars' official website.
Coach Gus Bradley on Friday said it's still too early to determine if Gabbert, or backup Chad Henne, will start.
If Gabbert does play, the Chiefs should anticipate more of the fast-paced attack we saw from the Jaguars in August, a game plan that emphasized quick releases in the passing game.
Blaine Gabbert was the only QB to finish preseason averaging under 2 seconds per attempt. 76.9% of his passes came out in under 2.5 seconds.â Pro Football Focus (@PFF) September 3, 2013
Piling on Gabbert has become something of a parlor sport on Twitter, but the quarterback showed signs of progress in the Jaguars' up-tempo offense during the preseason. He's under tremendous pressure to carry that over into September and prove he's one of the NFL's 32 best quarterbacks.
UPDATE: Jaguars tight end Marcedes Lewis was ruled out for the Chiefs tilt with a calf injury, the team announced. Meanwhile, Jags running back Justin Forsett (toe) and guard Will Rackley (ankle) are questionable.The "Around The League Podcast" is now available on iTunes! Click here to listen and subscribe.


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It's the holiday season, a time of goodwill and cheer amongst mankind. That should extend to the roads as well. What's the best way to be a more polite and courteous driver?
For me, merging is an area where we could all just be a little kinder. I don't want to stop and let a line of 35 cars in, but there are little things we can do. In an alternate merge, don't try and block someone out. You're going to lose one car length, and in the long run, is that really worth it?
Also, if you see someone merging onto the highway, why not move over a lane if you can to let them get on the road easier? Little things like this just make the road a more pleasant place to be.
What say you? What's the best way to become more polite on the roads?
Photo Credit: Shutterstock


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Ancient History Encyclopedia
Ancient History Encyclopedia is a non-profit educational website founded in 2009 aiming to provide the best ancient history information on the internet for free.
With in-depth definitions, high-resolution illustrations, a broad range of articles, searchable timelines, interactive maps and a continually updated catalogue of books, the Ancient History Encyclopedia envisions itself as a guardian and supplier of exceptional resources, enhancing the public's knowledge of the ancient world.
All content materials on this Open Education Resource are reviewed for quality assurance before publication. A group of expert volunteers, many of whom are experts in their respective fields or pursuing advanced studies, peer-review the content of the website to ensure quality.


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The iPad finally has some competition. After dominating the tablet market since its inception, the iPad's one-year anniversary will bring major competition, including RIM's BlackBerry PlayBook, Motorola's Xoom, and Dell's Streak 7. We lined them all up to see whether any of them will ultimately manage to topple the reigning champ.
That said, the iPad actually has a bit of an artificial disadvantage in this comparison, because it's old and up for replacement soon, while the others are brand new. It will largely be the iPad 2 that will be competing with the other tablets on the list, so I'll try to add what I think will be in the iPad 2 as we go through the comparison to provide more balance. I've had the Dell Streak 7 for several days, and have an iPad in house, but have not used the Playbook or Xoom so will be working off of known stats entirely for these devices.
We're going to look at screen size, network performance, processor performance, whether they can be tethered, DLNA support, operating system, number of apps, Flash support, cameras and quality, sensors, max storage, portability and battery life. This is in no particular order.
Screen size
The Streak 7 and Playbook both have 7-inch screens, bringing them more in line with the original Kindle form factor. Due to weight, this is better for books and for women who want to be able to put one in a purse. For men, you could put it in a coat pocket, but it clearly wouldn't be as portable as the Streak 5, and Dell has a line that will include a 10-inch product later in the year. Dell's advantage over the other players, at least initially, will be one of choice, and they maintain a consistent user experience across the line. Ideally, you might buy several and pick the one that most fit what you wanted to do, but at initial prices, I doubt there will be many who can afford to try this.
Seven-inch and smaller screens are better for use that is closer to a radio, video player or e-reader. Ten-inch screens are better for Web surfing, note taking, light productivity, and viewing digital pictures. You're more likely to carry a 7-inch tablet as a supplement to a laptop, and a 10-inch tablet on its own. It depends what you want to do, kind of like comparing a sports car and an SUV.
Network performance
These things live off the Web, and the faster the better. All but the iPad are 4G devices, but I'm expecting the iPad 2 to close this gap by adding 4G. Initially the Streak 7, Xoom, and Playbook will have an advantage here, but they will likely lose it before the year is half over.
Processor performance
The only product that doesn't have a new dual-core processor is the iPad, and both the Xoom and the Streak 7 have Tegra 2 chips, which deliver strong graphics. Multiple cores provide better multi-tasking performance. Historically, the primary benefit of that is the ability to use anti-malware products (the Streak 7 ships with one) without bringing down system performance critically. This last point is becoming more important as hackers focus more and more on these emerging platforms.
The views expressed here are solely those of the author and do not reflect the beliefs of Digital Trends.


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If the brokers in your conventional cluster are using JDBC-based data stores, use the following procedure to convert to an enhanced cluster. The procedure assumes that individual standalone broker data stores reside on the same JDBC database server.
Back up all persistent data in the standalone JDBC-based data store of each broker.
Use proprietary JDBC database tools.
Shut down all client applications.
Shut down all brokers in the conventional cluster.
Convert each standalone data store to a shared data store.
Use the Message Queue Database Manager utility (imqdbmgr) subcommand
imqdbmgr upgrade hastore
to convert an existing standalone JDBC database to a shared JDBC database.
Reconfigure all brokers for an enhanced cluster.
See Enhanced Broker Cluster Properties. It is recommended that you use a cluster configuration file to specify cluster configuration property values, such as the imq.cluster.clusterid, imq.persist.store, and additional shared JDBC database properties.
Start all brokers in the enhanced cluster.
Configure client applications to re-connect to failover brokers.
Client re-connection behavior is specified by connection handling attributes of the connection factory administered objects (see the Connection Handling). In the case of enhanced broker clusters, the imqAddressList, imqAddressListBehavior, and imqAddressListIterations attributes are ignored, however the imqReconnectAttempts attribute should be set to a value of -1 (unlimited).
Start all client applications.
Resume messaging operations.


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Federal Pell Grant
The Federal Pell Grant is the most well-known grant based solely on financial need. The Federal Pell Grant is a Title IV Program that provides eligible undergraduate students, who meet certain income guidelines as determined by the U.S. Department of Education, with aid to help meet the costs of postsecondary education. Pell Grant does not require repayment. Eligiblility is determined by the U.S. Department of Education using a student's expected family contribution (EFC), a formula developed by the federal government, and the number of credit hours in which a student is enrolled. Students must be qualified undergraduates enrolled in a federally approved eligible program leading to a degree, diploma, or eligible Technical Certificate of Credit. Pell Grant is not available to students who have a bachelor's degree, owe a refund to any Title IV Aid Program, or are in default on a student loan. Pell Grant recipients are subject to a Lifetime Usage Limit of 600%, which is 6 full time years in which a student receives their full annual Pell Grant award each year or the equivalent in part-time attendance.
For the purposes of Pell, NGTC operates on a two term disbursement schedule. This means that a student's full Pell Grant Award is divided into two disbursements. The annual maximum Pell Grant Award ($6,095 for 2018-2019) is divided over the Fall ($3,048) and Spring ($3,047). Any remaining funds are available for disbursement in the Summer Semester. Students who are enrolled for at least 12 credit hours both Fall and Spring Terms are strongly encouraged to save a portion of any financial aid refund to help cover the cost of Summer Semester. If a student is not enrolled for at least 12 credit hours bothFall and Spring Term, they should have a portion of their annual Pell Grant award available to disburse for the Summer Semester. Enrollment status determines the amount of Pell Grant funds awarded each semester. Please note that not all students will receive the maximum Pell Grant award. The award amounts are determined by the Department of Education, the number of enrollment hours, and other various factors.
|Credit Hours
|Amount of Semester Pell Award
To apply, students must complete the FAFSA by visiting www.FAFSA.ed.gov.
The HOPE Grant
The HOPE Grant is another well-known grant which is available to qualified Georgia residents who are enrolled in a diploma or technical certificate program. High school grades, graduation dates, and family income are not a consideration in determining eligibility.
Assistance covers a percentage of tuition for a maximum of 63 credit hours. Room and board costs, mandatory fees, and books/supplies are not covered through the HOPE Grant.
Students must maintain a 2.0 cumulative Grade Point Average to remain eligible. Student GPAs are checked once they have completed 30 credit hours and again at 60 credit hours.
Requirements for the HOPE Grant can be reviewed on the Georgia Student Finance Commission's website found here: HOPE Grant
To apply, a student should complete the FAFSA or GSFAPPS Application.
HOPE GED Voucher
The HOPE Grant also awards a one-time $500 voucher to qualified Georgia residents who pass the GED® exam. The voucher is to be applied toward the cost of education in a degree, diploma, or technical certificate program.
The Zell Miller Grant
The Zell Miller Grant is available to qualified Georgia Residents who are enrolled in a diploma or certificate program. High School grades, graduation dates, and family income are not a consideration in determining eligibility for the Zell Miller Grant. Assistance will cover the full amount of tuition. Room and board costs, mandatory fees, and books/supplies are not covered through The Zell Miller Grant. Students should strive to maintain a 3.5 HOPE-Cumulative Grade Point Average to remain eligible for The Zell Miller Grant. Students who fall below the required 3.5 HOPE-Cumulative Grade Point Average at the End-of-Term checkpoint will lose eligibility for The Zell Miller Grant. Students may receive The Zell Miller Grant or a combination of HOPE/Zell Miller Grant funding for a maximum of 63 semester credit hours.
Requirements for the Zell Miller Grant can be reviewed on the Georgia Student Finance Commission's website found here: Zell Miller Grant
To apply, a student should complete the FAFSA or GSFAPPS Application.
HOPE Career Grant
HOPE Career Grant is a state grant program that is available to qualified Georgia residents who receive the HOPE Grant or Zell Miller Grant and are enrolled in one of the listed approved diploma or technical certificate programs:
Air Conditioning Technology, Applied Business Technology, Automotive Technology, CNC Technology, Commercial Truck Driving, Diesel Mechanic, Early Childhood Care/Education, Electrical Lineworker, Healthcare Technologies, Industrial Systems, Information Technology, Internet Specialist, Medical Coding, Medical Front Office, Networking Specialist, Pharmacy Tech, Pipe Welder, Practical Nursing, Web Application Development, & Welding.
To qualify, a student must be fully admitted to the college, enrolled in one of the above programs and receiving the HOPE Grant or the Zell Miller Grant for the same term.
Enrolled Hours
Award Amount per term
9+ hours
3 - 8 hours
1 - 2 hours
*Commercial Truck Driving - enrolled 9+ hours; one-time award $1,000.00
Federal Supplemental Educational Opportunity Grant (FSEOG)
The FSEOG program is administered directly by the NGTC Financial Aid Office and is therefore called "campus-based" aid. This grant is awarded to undergraduate students who have exceptional financial need and who have not earned a bachelor's or graduate degree.
Each participating school receives a certain amount of FSEOG funds each year from the U.S. Department of Education's office of Federal Student Aid. Once the full amount of FSEOG funds has been awarded to students, no more FSEOG awards can be made for that year, so it is important for you to apply for student aid as early as you can. Check with the Office of Financial Aid for more specific guidelines.
Questions regarding eligibility for grants can best be answered by contacting your Financial Aid Advisor.


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Physical Activity, Exercise and HIV
October 23, 2015
Table of Contents
What Are Physical Activity and Exercise?
Physical activity is any activity that gets your body moving. It includes any activity that is part of your daily life -- from sweeping and cleaning to carrying groceries, gardening, walking, dancing, riding a bicycle, lifting weights at the gym, stocking shelves in a store, or tossing a ball around with friends.
Exercise is a type of physical activity. Exercise is activity that is planned and done on a regular basis (e.g., several times a week) for enjoyment or for improving any aspect of physical fitness -- strength, flexibility, or endurance. There are two main types of physical activity or exercise that the US Department of Health and Human Services (DHHS) recommends for adults: aerobic (cardiovascular or "cardio") and muscle-strengthening (resistance).
Labeling something a physical activity or an exercise is not nearly as important as understanding that the human body was designed to move, and stays healthier when doing physical activity. In other words, being active with your body -- whether it is through small amounts of activity throughout the day or scheduled blocks of time for more strenuous movement -- contributes to a longer, healthier life. Even small changes in your normal life can greatly enhance your activity level and your health: taking the stairs instead of the elevator, carrying instead of wheeling groceries through the store, walking a short distance instead of driving the car.
It is important to know that neither expensive equipment nor difficult techniques are necessary in order for you to be physically active. Aerobic activity can be as simple as walking or cleaning your home with some added pep in your step. If it is unsafe or uncomfortable outside, try walking the stairs in your building or stepping up and down off the first step of a sturdy step-stool.
Muscle-strengthening activities can be simple, too. All it takes is your body and a floor -- for sit-ups, push-ups, or deep-knee bends. If you want to lift weights, try cans of food, jugs of water, or a spare brick. There are many ways to be safely physically active without spending a lot of money or going special places.
Benefits of Exercise and Being Physically Active
There are many ways in which physical activity can improve your health -- it can build and maintain muscle, increase your endurance, and strengthen your heart. In addition, there are many benefits of exercise that are especially helpful for people living with HIV (HIV+). Being physically active and having an exercise routine can:
There is also a connection between muscle mass and immune function. People who exercise often have higher CD4 counts and fewer side effects from HIV and HIV drugs.
Because powerful new HIV drugs are allowing many people living with HIV to live long, full lives, many of the medical problems facing people living with HIV now have more to do with diseases of aging than HIV-related illnesses. Being physically active is important in preventing aging-related health issues. In addition to the benefits listed above, there is strong evidence to suggest that being physically active lowers your risk for:
How Much and What Type of Physical Activity Do You Need for Health Benefits?
According to the DHHS, there are two types of physical activity that adults need each week to improve their health -- aerobic and muscle-strengthening activities.
Aerobic (Cardiovascular, "Cardio") Activity
Aerobic exercise uses oxygen to burn fat in your body. This is why people who are trying to lose weight often do a lot of aerobic exercise. It is also called cardiovascular exercise, because it raises your heart rate and makes your heart stronger. Besides burning fat, it can increase your endurance so that you do not get tired as quickly when you are active. Aerobic exercises can also lower cholesterol, triglycerides, and blood sugars.
Aerobic activity is often described in terms of its intensity, or how much effort it takes to do something. During moderate intensity activity, your breathing and heart rate become a bit higher and you will likely be a bit sweaty at the end. Another way to think of moderate intensity activity is any activity during which you can talk but not sing. During vigorous intensity activity, a person cannot say more than a few words without pausing for a breath, since vigorous effort causes your heart rate and breathing to increase substantially.
Examples of moderate aerobic activity include:
Examples of vigorous aerobic activity include:
To see substantial health benefits, the DHHS recommends that adults need to do at least:
Aerobic activity should be done for at least ten minutes at a time; however, how you reach your total weekly goal is up to you. For example, if you aim for 150 minutes of moderate activity per week, you could do 30 minutes of activity five days a week or ten-minute periods of activity 15 times throughout your week.
It is important to ask your health care provider if you have any conditions that might make it a bad idea to do aerobic activity -- especially muscle wasting or very little body fat.
Related Stories
This article was provided by The Well Project. Visit The Well Project's Web site to learn more about their resources and initiatives for women living with HIV. The Well Project shares its content with TheBody.com to ensure all people have access to the highest quality treatment information available. The Well Project receives no advertising revenue from TheBody.com or the advertisers on this site. No advertiser on this site has any editorial input into The Well Project's content.
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The Commission on Science and Technology for Development (CSTD) is a subsidiary body of the Economic and Social Council (ECOSOC).
The Commission provides the General Assembly and ECOSOC with high-level advice on relevant science and technology issues.
UNCTAD is responsible for the substantive servicing of the Commission.
Labour markets and educational needs are being transformed for women and young people by the onslaught of fast-moving technological change, a United Nations commission hears
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It's been a minute since we've consulted our CFL rulebook, but we need to see how many kilograms or hectares or whatever they penalize you for piling on.
Because Hall of Famer Warren Moon added his voice to the down-with-Tim Tebow chorus, saying the Canadian Football League wasn't a good fit because of the emphasis on passing, saying that was Tebow's "biggest problem."
"You have to be able to throw the ball up there if anything and they throw the ball a lot," Moon told Houston's 610-AM, via the New York Daily News. "There are only three downs so the passing game is much more important up there. You have got to be able to throw it and I think that's his biggest problem, just being [able] to complete passes, be an accurate passer. I think he's a really good athlete playing the position but I don't think that's enough sometimes."
Moon spent six years in the CFL before he got to the NFL, but said the difference between him and Doug Flutie going North of the border and Tebow was about chances, which Tebow has had.
"We were very good passers. That had nothing to do with it. We didn't have to go up there and try and change our throwing motion," Moon said. "We didn't have to go up there and try and become more accurate. We just needed to get the opportunity. . . .
"He's worked as hard as anybody can but there just hasn't been that much improvement made in his quarterback fundamentals and his technique so he might think about maybe playing another position if he wants to stay in the NFL."
At the moment, no one's rushing to Tebow's defense and saying Moon's wrong. But not succeeding in the mess that was New York last year shouldn't necessarily be an indictment, and the guy has had playoff success.
There are a lot of quarterbacks in the NFL who can't say that, and still have employment without being destroyed in the court of public opinion every day.