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SOURCE: WhereverTV Broadcasting Corp.
February 18, 2014 10:00 ET
WhereverTV Outlines Plan to Become World's First Global Television Service Provider
WhereverTV Outlines Plan to Become World's First Global Television Service Provider
PITTSBURGH, PA--(Marketwired - Feb 18, 2014) - WhereverTV Broadcasting Corp. (OTC Pink: TVTV), a leader in delivering Over the Top (OTT) subscription television services to a variety of devices, including Connected TVs, streaming media players, smartphones and TabletPCs, announced today its forecast for the Internet TV and Over-the-Top (OTT) industry for 2014. The forecast includes a prediction of the Aereo case before the Supreme Court, as well as its own very ambitious plans for the year from a compliance, product development, and subscription services perspective. WhereverTV has posted their 2014 plan to their website which includes the intent to sign additional content licenses with broadcasters, the intention of launching of their US based Internet television service, the commencement of a subscription drive, the intent to raise working capital and their intent to file necessary documentation with the Securities and Exchange Commission (SEC) to become a fully reporting company. For details of the WhereverTV 2014 Plan, please visit http://www.wherever.tv/html/pdf/2014_Plan.pdf.
The filing of necessary documentation with the SEC includes the completion of audited financials for which the company has engaged both a Certified Public Accountant and a PCOAB registered Audit firm. This work has already commenced. The preparation of financials, the completion of the audit and the filing of necessary documentation with the SEC is targeted for the end of March 2014. The Company is taking the necessary steps to receive approval from the SEC in order to become a 'fully reporting' company, and to up-list its shares from an OTC PINK listing status to an OTCQB listing status. Mark Cavicchia, TVTV's CEO, stated, "We want to demonstrate that we value our shareholders and stakeholders and feel that the up-listing effort and a fully reporting status conveys our commitment to regulatory compliance, full disclosure and shareholder value."
With the continued rapid growth and acceptance of recorded content via OTT services that include Netflix, Hulu & other OTT platforms, the Company believes it is well-positioned for substantial growth in 2014 when it offers its real-time over the top content from more countries and to more countries. TVTV continues to offer its Arabic, Moroccan, Greek and GlobalTV television subscription plans, while it prepares to launch its US based service. Meanwhile, the Company continues to pursue its patent pending technology, the Global IPG. Mr. Cavicchia went on to say, "The ability to incorporate over the top services with traditional pay television services is something consumers are not only learning to enjoy, but are starting to expect from their on-screen program guides. WhereverTV's Global IPG is the ideal solution to this growing desire."
The most ambitious goal of WhereverTV for 2014 is the launch of its US television subscription service. Although the Company began negotiating rights with US television networks in 2012, it believes it finally has enough compelling content available to launch a US service aimed at the 110 million existing cable and satellite households looking to lower their cable bill, as well as the more than 40 million consumers of recorded over the top subscription services offered by Netflix, Hulu and others. "The timing to launch a live-streaming OTT US service couldn't be better," stated Cavicchia. "With Netflix's 38 million subscribers and the Aereo decision headed to the Supreme Court this April, we believe a legally agreed over the top subscription service will be well-received by US consumers." The Company has successfully agreed to terms with more than 50 US television networks and is in active discussions with many others. WhereverTV expects to launch its US service with approximately 80 television channels and 40 audio channels.
The Company also continues to expand its international subscription offerings. With nearly 170 million pay television subscription households, Western Europe is the second most valuable television market in world behind the Unites States. And since WhereverTV already delivers its free services to customers in 189 countries around the world, the Company is looking to establish a foothold into Western Europe by partnering with an established OTT platform provider or streaming media OEM with a substantial number of devices already in consumers' homes. By partnering with a device manufacturer that has existing penetration into this market, WhereverTV will be able to more quickly reach television sets with its subscription services across Western Europe.
Cavicchia has also predicted the outcome of the current Aereo Supreme Court case. Mr. Cavicchia believes that the matter of: AMERICAN BROADCASTING COMPANIES, INC.; DISNEY ENTERPRISES, INC.; CBS BROADCASTING INC.; CBS STUDIOS INC.; NBCUNIVERSAL MEDIA, LLC; NBC STUDIOS, LLC; UNIVERSAL NETWORK TELEVISION, LLC; TELEMUNDO NETWORK GROUP LLC; WNJU-TV BROADCASTING LLC; WNET; THIRTEEN PRODUCTIONS, LLC; FOX TELEVISION STATIONS, INC.; TWENTIETH CENTURY FOX FILM CORPORATION; WPIX, LLC; UNIVISION TELEVISION GROUP, INC.; THE UNIVISION NETWORK LIMITED PARTNERSHIP; AND PUBLIC BROADCASTING SERVICE Petitioners, v. AEREO, INC., F/K/A BAMBOOM LABS, INC., Respondent, will be decided in favor of the broadcasters.
"It is difficult to fathom a scenario in this country where a company's product or service can be redistributed, rebroadcast and/or monetized by another company, without including some form of agreement or payment to the license holder of that product or service," stated Mr. Cavicchia. "For this reason, we closely monitor the developments of this case because we remain intent on pushing out our own business model with the blessing of the broadcast industry by paying them their rightful licensing fees due them if/when we rebroadcast someone else's content. However, regardless of how the Supreme Court decides, we feel WhereverTV lands in a very enviable industry position to meet the changing needs of consumers as it relates to their television accessibility and channel line ups. This is why we are rolling out our US service as soon as possible in 2014, in preparation for either outcome," he added.
To learn more about WhereverTV, please visit www.wherever.tv.
About WhereverTV Broadcasting Corporation
Founded in 2007 by Mark Cavicchia, WhereverTV is the next generation subscription television service, providing consumers with licensed, live-streaming programming identical to existing cable & satellite providers, with the only difference being that the broadcast signal is received via the internet. WhereverTV provides a subscription TV over internet service that is an alternative to traditional cable and satellite services, with the added benefits of personalization and portability across many of the most popular web connected devices. Also known as Internet TV, WhereverTV delivers these same channels, shows and events to SmartTVs and digital media receivers, including: GoogleTV, AppleTV, Roku, Boxee, iPhone, iPad, iPod Touch, Droid Smartphone, and TabletPCs through the public Internet via an over the top (OTT) platform. The WhereverTV platform manages licensed and free to air content across these devices and unlimited geographies wherever there is internet connectivity. The customer viewing experiences are based on customer location (geo-targeting) and content-rights management (subscriptions). Current in-language subscription offerings include Arabic TV, Greek TV and Moroccan TV. Apps are presently available for iOS (Apple), Android and GoogleTV devices. DVR functionality to record your shows and view later is presently in the works. Licensed US TV content subscriptions will be available in 2013. Smart phone apps are available in App Stores for free. Please visit: www.wherever.tv, for more info.
This news release contains forward-looking statements, which may not be based on historical facts. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements. These factors should be considered carefully and readers are cautioned not to place undue reliance on such forward-looking statements. Except as required by applicable securities laws, the Company disclaims any obligation to update any such factors or to publicly announce the results of any revisions to any of the forward-looking statements contained herein to reflect future results, events or developments.
Steve M.
Ph: 412 663 0094
Email: firstname.lastname@example.com
Steve M.
Ph: 412 663 0094
Email: email@example.com
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Gold prices touched a one-month high near $1,699 on Thursday as a slightly weaker greenback and a spike in black gold inspired short-term specs to buy the metal at its daily lows in the morning hours. The yellow metal had suffered a brief swoon on the back of a sharp decline in U.S. jobless claims filings (more on U.S. economic statistics follows below). Spot bullion finished at $1,687 per ounce in New York. Silver gained 24 cents to end the session at $31.73 the ounce.
The midweek-issued EW short-term potential price targets (of $1,710 and $32.50 respectively) remain viable for gold and silver, barring technical failure at overhead resistance levels. This morning's final trading session of the week saw gold advancing a more modest $2 an ounce (to $1,690) and silver up by one penny at $31.75 the ounce. Platinum fell by $8 but remained within striking distance of a price parity paradigm with the yellow metal while palladium dropped $2 to ease to $721 per ounce. Rhodium remained at rest at the $1,150 per ounce bid-side level.
In the markets' background, the U.S. dollar moved to within 0.01 of the pivotal 80 level on the trade-weighted index despite a plethora of bearish calls made against it in the wake of last week's ECB interest rate non-action. Crude oil eased back to $95.36 and copper advanced 0.34% after Chinese reports showed the country's economy growing at 7.9% in QIV of 2012 — a number one-tenth of a percent better than market expectations. That is, provided the figures from China are reliable. In any case, the greenbacks advance to the 80 mark showed that the "China effect" was quite short-lived with investors.
In any case, if one were to take a somewhat closer look behind the latest number from China, one might find some "shocking" data (CNBC's words, not ours). The other "Beige Book" (also called the China Beige Book) shows that loan demand in the world's second largest economy has virtually evaporated. Such a contraction in borrowing activity (80% of lending went to roll-overs) means that there is no funding of new growth and that means that this is not a time of strong economic expansion, the 7.9% figure notwithstanding.
Economic growth and/or the lack thereof dominated the financial stories at the mid-point of this week. The Fed's Beige Book survey revealed that the U.S. economy grew at what was labeled a "modest or moderate" level in various parts of the country during December and (very) early this month. The report contained a mixed review on manufacturing activity, with three out of twelve Fed districts showing a decline in such readings. It is safe to assume that Fiscal-You-Know-What worries impacted the final results somewhat. Nevertheless, experts saw rosy tinges in the content of the normally…beige one.
Notwithstanding some of the contents of the Beige Book and the fiscal wrangling still underway on Capitol Hill, departing Treasury Secretary Timothy Geithner sized up the American economy as being close to the final stages of full recuperation from the financial crisis. As we near the home stretch for the current market week, we do have a nice harvest of positive US economic news to relay — some of which supports Mr. Geithner's assertions, and some of which made for a nice "risk-on" day in the markets on Thursday.

subset: commoncrawl


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When a credit card company says they'll give me free credit for 12 months, I consider paying off my balance before the end of the period -- and avoiding the interest charges that will appear if I don't -- a challenge.
Continue Reading Below
My romance with these offers started several years ago when the receptionist for my son's orthodontist flashed me a toothy grin and handed me the bill for his braces. I gulped at the total and decided to apply for a card that offered a zero-interest period to help handle the expenses. I paid that balance off before the end of the period, and I've since financed several dental and veterinary bills the same way.
But before you opt to use a 0% offer to pay down your bills, here are five tips to keep in mind.
1. Read the fine print
Before you apply for a new card, make sure that's exactly what you're getting. With a 0% offer, the promotion expiration is the date by which you must pay off your balance or else the remaining amount will be subject to the standard APR from that point forward -- usually between 12 and 24%. Also note that these cards still typically require a monthly minimum payment during the 0% period. If you fail to make that payment in time, you may pay a hefty late fee and even forfeit your 0% status.
2. Calculate your payments
To take full advantage of a 0% card, it's helpful to calculate how much you will need to pay each month to pay off your balance before the interest charges return. For instance, if you spend $1,000 and you get a six-month 0% deal, you would need to pay about $166 each month to avoid paying interest. Thinking you'll magically have $1,000 when the promotion period ends is bad budgeting and can often result in you returning to the world of paying interest, perhaps scarcely better off than you were before.
3. Avoid overextending
While a 0% card can help you pay for expenses that you might not otherwise be able to afford, you will pay more money if you fail to pay your balance off in time. Just because the credit card issuer is willing to offer you $4,000 for nine months doesn't mean you should use all of that credit at once -- unless you have in your budget $444 to make a payment each month.
4. Shop around
Not all 0% cards are created equal. Look for a card that gives you the longest promotional period possible, which can help you spread out the costs. For instance, $1,400 will cost you just $58 per month over 24 months, compared to $116 over 12 months and $233 over six months.
5. Watch those fees
If you'll be using a 0% card to make a balance transfer, be aware that there are generally fees involved, which typically amount to 3-5% of the amount transferred. Before you transfer a large amount of money, make certain you do the math on fees or you could negate your reason for making the transfer in the first place.
Used responsibly, a zero-interest credit card can be a great way to avoid interest payments and improve your financial standing. Rising to the challenge of paying off your balance in a timely manner can offer a nice feeling of satisfaction too.
The original article can be found at MoneyBlueBook.com:5 tips for handling 0% credit card offers


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What If Harry Potter Tried to Get to Hogwarts in Real Life? [VIDEO]
In case you ever wondered how Harry Potter would fare trying to get to Hogwarts in real life, thanks to Improv Everywhere, you'll wonder no more. The hilarious improv group -- famous for their movie recreations in real life -- sent 11-year-old actor Sebastian Thomas (clad in glasses and toting a caged owl) to New York's Penn Station, asking for help finding Platform 9 3/4. While some were confused, some genuinely tried to help -- and, best of all, some even went along with the act. And major props to Thomas, who stayed in character the entire time. Watch it above!


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Omix-Ada Hub Lockout Kit Install - DisconnectPosted in How To: Transmission Drivetrain on March 28, 2014
After six days on the Rubicon Trail, playing here and there, camping at the springs, and wheeling back out past Loon Lake, we hit the road at about ten o'clock at night heading to our hotel about 60 miles away. We had planned to go out through Cadillac Hill and end up at Lake Tahoe, so that's where we reserved our hotel. We knew we'd be on the trail all day long and at best would be hot, sweaty, and tired. Instead, we had an even longer day on the trail, and then got to run about 50 miles of highway to get to our hotel or lose the money from the reservation. Of course, as soon as we hit the road, we were greeted with a new vibration and a noise that we'd never heard before.
The Jeep was caked in trail mud, but we dove underneath and started investigating all the usual suspects—to no avail. Then, dirtier and even more tired, we hit the road, keeping our ears peeled for the noise getting worse. We got into the hotel at around 2 a.m. with nothing going boom and just crashed. First thing in the morning, we pulled a week's worth of camping gear from the back of the Jeep to get to our tools and started testing and pulling parts to find the problem. We eventually discovered that the factory front driveshaft's double-cardan joint bit the big one after 140,000 miles and a decade of hard wheeling. We pulled the shaft, but still had a vibration which we eventually discovered was a bad axleshaft U-joint. We decided it was time to go retro with this Jeep.
We turned to Omix-Ada for a hub lockout kit. Now, with a simple flip of the switch, we can stop the entire front end spinning. Sure, it means we have to get out of the Jeep to actually have 4WD, but after that trip we think it is worth it. Another added benefit of disconnecting the front end should be a mileage gain, but one benefit we are sure of is that without those parts spinning all the time, everything will last longer.
The kit replaces the unitbearings with spindles and serviceable bearings. If you are the kind of guy who thinks "grease gun" is a dirty word, this probably isn't for you. Unlike unitbearings, the new wheel bearings might need attention from time to time. But, we like being able to check that sort of thing rather than just running it till it dies, and we have several grease guns, so we are good to go. Also, the kit replaces the factory shafts with chromoly ones for a huge increase in strength there.
We didn't want to change our 5-on-41⁄2-inch bolt pattern, and we didn't want to mess around with custom machining brake rotors like some 5-on-51⁄2-inch lockout kits force you to do. So even though it isn't as strong as the bigger bolt pattern might be, the company rates it to a 35-inch tire, which just happens to be the size that we were running. The kit includes chromoly Alloy USA shafts, some cool Alloy USA U-joints, and all the parts needed for installation. Once we had that installed, we turned to Tom Wood's Custom Driveshafts to replace the non-greasable factory one. Here's how it all turned out.


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Heber Fuger Wendin (HFW) is an independent, fee-only financial advisor and investment counsel firm established in 1934. Our services include bank investment and credit union investment advisory services, portfolio accounting, mortgage servicing rights valuation, asset liability and other financial consulting services.
We currently manage over $4 billion in assets for over 100 clients throughout the Midwest and Southern United States. In addition to community banks and credit unions, our investment advisory clients include insurance companies, hospitals, foundations and individuals. As a fee-only Registered Investment Advisor, we take no commissions; this allows us to provide more independent and objective advice for our clients. We are a fiduciary, not a broker, which means we place our clients' interests first – ahead of our own.
Above all else, HFW's investment recommendations to our clients are based on our 80-year culture as a fiduciary advisor. A core value of Heber since our founding in the Great Depression is to always put the clients' interests first. Not only is that our fiduciary obligation, it is embedded in the culture of our firm. It is more than a legal requirement to us; it is a moral responsibility.
NOTE TO CLIENTS: *NEW* Our ADV report for 2018 is now available. To find it, please access the Client Info under Account Log-in on the upper right of this screen. Our approved broker list is available there as well. Just give our office a call if you need the password.


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A Clairvoyant by birth & a blessed channel of light she is an accomplished Angel Certified Practitioner trained under Charles Virtue, Clinical Hypnotherapist from California Hypnosis Institute of India, Theta Healer, Intuitive Numerologist, Crystal Healer...
KripaJyoti Nisha Singla (PGDBM) is a Spiritual master, Energy worker, Reiki Master, Theta Instructor, and a dedicated Artist who has been working in the field of healings, spirituality, counselling, relationship healing, family therapy and alternative medicine therapies from more than 12 years.
Kirti Kanodia is a certified Theta Healer, Trained Family Constellation Facilitator, Tarot card Reader, Past life Regression Therapist, Angel card reader, Inner child integration, Astrologer, Tasso Therapist and Reiki Master.
Past life Regression Trainer, Family Constellation Trainer, Theta Healing Trainer, Inner Child Work, Angel Therapist, Reiki healer, Hypnotherapy, Crystal Healing, Graphology, Tarot card reader & Astrologer
Theta Healing is a healing technique that works at the energetic, atomic level of our existence; and has been described as the practical application of quantum mechanics.
When you learn Theta Healing, you discover how to use the Theta Brainwave to reach a level of consciousness that allows you to change your emotional, mental, spiritual or physical reality instantaneously.
Theta Healing is a simple, practical, straight-forward technique that is easily learned and refined through repeated use. The more you use it, the more you develop your conscious awareness of the day to day things around you, as well as your unconscious consciousness of the intangible world.
Theta Healing is iNoidaedibly simple and anyone can learn it - whether you are on your own path of personal development, a Practitioner in a related area or just plain curious!
Practitioners with backgrounds in Psychotherapy, Coaching, NLP, Reiki, Naturopathy and other coaching and alternative therapy related backgrounds have found Theta Healing to be a natural extension to the skills that they already have. They have easily incorporated the Theta Healing technique into their work with fantastic results.
In addition, Judges, Medical Doctors, people with corporate backgrounds, Students, Mums, Dads and many, many people from all walks of life have learned Theta Healing. They use it to improve their daily personal and work lives, and some have even gone on to become Theta Healing Practitioners and Theta Healing Trainers.
The possibilities for using Theta Healing are truly infinite and are really only limited by your imagination and desire to "try it" in any given circumstance!
For instance, it has been used in such diverse areas as healing rifts in relationships, gaining confidence for public speaking, helping secure new jobs, manifesting the ideal home and partner, and improving sales performance and business relationships at work.
You can use Theta Healing on yourself, your friends and family and even your animals.
When you use Theta Healing, you connect to Universal Consciousness, the Energy of All That Is, using the Theta Brainwave. This is the energy from which all things are created. It is here that the work of instantaneous change / healing is performed.
The Theta Healing Practitioner will help you identify unconscious beliefs that are holding you back, or that can lead to physical unease in your body. Many people may be aware of conscious "limiting" beliefs, fears or doubts that prevent them from achieving what they desire. However over the years, we have discovered that there is often an UNCONSCIOUS belief or program that is at the root of the problem.
Once the Theta Healing Practitioner has helped you identify the root belief, they will then use the Theta Brainwave to go the Energy of All That Is, and command and witness an instant change to that belief. The act of Witnessing - i.e. the observation that this belief has been changed, is the key to the success of ThetaHealing. Once the witnessing is complete, the root belief and all beliefs that have arisen from it, are changed instantly. The effect can be felt immediately, and the client's relief is fast and permanent.
Many people do not yet realise that their emotions and beliefs have a direct impact on the physical state of their body. It is not just what we eat and drink or the environment around us that affects our physical well-being, but also what we think and say to ourselves and others on a daily basis. Theta Healing can help you address the emotional and psychological stresses and negative beliefs and programs that may be impacting your physical wellbeing.
Pallavi Velugu
Theta Healer.


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Play games more comfortably on the next generation PS VIta with CTA Digital's Hand Grip for PS Vita. This sleek and ergonomic grip is styled after the comfortable form of a home console controller and easily fits around the PS Vita without blocking any buttons or ports. There's even a specially designed opening in the back for full access to Vita's unique rear touch pad. The Hand Grip transforms the handheld portable device into a familiar gaming controller and together with Sony's cross play technology you can enjoy using the Vita to interact with the PS3. So get a hold of more comfortable control using CTA Digital's Hand Grip fro PS Vita.
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DistributionWatch Review: SuSE Linux 7.0 Personal/Professional
Geeko the Gecko? Urgh!
In the interests of full disclosure, I must reveal that I participated in the "Name-the-SuSE-lizard" contest last February at the Manhattan LinuxWorld. My entry of "Get the Hell Away From Me You Big Green Thing!" did not win, for some reason, and I freely admit I hold no bitterness towards SuSE for picking the name "Geeko" instead. Really.
As the Linux community holds its collective breath waiting for the 2.4 kernel, which is starting to get to be more anticipated than the Land of Milk and Honey was to that bunch of lost Hebrews a few thousand years ago, each new Linux distribution released these days gets scrutinized for features that might help ease the wait.
Red Hat 7.0's recent release was ransacked by the user community, looking for the next Big Thing. The response has been less than overwhelming thus far. But while all the hoopla about Red Hat was going on here in the States, the latest release from Deutschland has quietly been causing a stir of its own, first in its home country, and now here.
SuSE Linux 7.0, the latest offering from the Germany-based SuSE GmbH, comes in two distinct offerings--Personal and Professional--as well as an Upgrade version for current SuSE users. Superficially, there is little difference between the products, even in price. The SuSE Linux 7.0 Personal costs a mere $39.95, the Upgrade version $49.95, and the Professional version just $69.95, should you choose to pick them up off the shelf. Downloading is available, as with most Linux distributions, but in this instance, I strongly recommend plunking down the cash for this distro.
Tale of the Tape
The two versions I review here, Personal and Professional, both come with well-written documentation, including (in the Professional version) a very complete near-600-page Technical Handbook that answers a lot of questions for both new and mid-level Linux users. The Configuration manual that comes in both editions was also full of real-world examples to get you going including a detailed section on getting an IDE CD-RW drive working with SCSI emulation in Linux, something I personally have been wrestling with these past few weeks.
The documentation alone is worth the price, not to mention the ease of use you get having an enormous number of packages on hand to install instead of having to find them online and then download them through a small pipe, if you are so cursed.
How enormous? Well, the Personal edition, targeted at home or office users who have had little to no exposure to Linux, ships with a nice neat number of 700 apps, all on 3 CDs. The Professional edition shatters that number with a whopping 1987 applications available, if you want them. Shipping will all of those packages means a whopping 6 CDs come in the box, or, if you've can handle it, one DVD.
The Upgrade version, geared to pull current SuSE users up to 7.0, includes all of the packages shipping with the Professional version--a nice reward for current SuSE customers.
The installation support for both versions are pretty standard for the industry: 60 days for Personal and Upgrade and 90 days for the Professional edition. Other support includes a pretty large support database on the SuSE Web site that I found easy to use in terms of functionality and clarity. I ran searches for several terms and found on-target results for most everything, though I had to try one search for CD writer drives a couple of times to get it nailed down. Every article I found had an equivalent translation in at least two other languages (usually French and German), with Spanish and Czech translations appearing as well. Both versions promoted support that was available via WAP cell phones, but I was unable to test this feature.
The Professional version included an offer for a trial membership in the Oracle Technology Network, and free Oracle software to download and check out, which I also did not test.
SuSE Linux 7.0 Personal
SuSE GmbH
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- Research
- Open Access
Inferring serum proteolytic activity from LC-MS/MS data
© Dittwald et al.; licensee BioMed Central Ltd. 2012
- Published: 12 April 2012
In this paper we deal with modeling serum proteolysis process from tandem mass spectrometry data. The parameters of peptide degradation process inferred from LC-MS/MS data correspond directly to the activity of specific enzymes present in the serum samples of patients and healthy donors. Our approach integrate the existing knowledge about peptidases' activity stored in MEROPS database with the efficient procedure for estimation the model parameters.
Taking into account the inherent stochasticity of the process, the proteolytic activity is modeled with the use of Chemical Master Equation (CME). Assuming the stationarity of the Markov process we calculate the expected values of digested peptides in the model. The parameters are fitted to minimize the discrepancy between those expected values and the peptide activities observed in the MS data. Constrained optimization problem is solved by Levenberg-Marquadt algorithm.
Our results demonstrates the feasibility and potential of high-level analysis for LC-MS proteomic data. The estimated enzyme activities give insights into the molecular pathology of colorectal cancer. Moreover the developed framework is general and can be applied to study proteolytic activity in different systems.
- Constrain Optimization Problem
- Mass Spectrometry Data
- Mass Spectrometry Image
- Precursor Peptide
- Cleavage Event
Motivation and related research
Recent advances in high throughput technologies, which evaluate tens of thousands of genes or proteins in a single experiment, are providing new methods for identifying biochemical determinants of the disease process. One of the experimental technologies allowing us to study molecular basis underlying specific disease phenotype is mass spectrometry (MS) [1, 2]. Observed large variability in mass spectrometry images of blood samples was attributed to ex vivo proteolysis.
Paradoxically, one can take advantage of these findings in cancer diagnostics [3, 4] as diagnostic peptides originate after ex vivo proteolytic processing of high abundance protein fragments.
As development in hardware and software progresses, we can obtain better and better estimates of peptide concentrations in body fluids, which give many insights into the peptide degradation process. Proteolysis modeled in this paper is the process in which a protein is broken down partially, into peptides, or completely, into amino acids, by proteolytic enzymes present in blood serum. Among proteolytic enzymes two main groups are distinguished. One group includes exopeptidases which require a free N-terminal amino group, C-terminal amino group or both and cut the peptide not more than three amino acids from the terminus. Enzymes belonging to the second group are called endopeptidases and they tend to cleave away from the end of the peptide.
Our results
In this paper we present formal mathematical model describing serum proteolysis dynamics. We focus here on the activity of peptide cutting enzymes (peptidases). The model parameters are inferred from liquid chromatography tandem mass spectrometry data (LC-MS/MS).
The dynamical changes in peptide composition caused by proteolytic degradation are described by means of biochemical reactions network. It corresponds to Markov process whose evolution is governed by the system of stochastic differential equations (i.e. Chemical Master Equation).
The current approach significantly extends the exopeptidase activity model presented in [5]. The integration with peptidase database MEROPS (http://merops.sanger.ac.uk) [6, 7] allows for modeling the endopeptidase activity as well. Moreover the model parameters inferred from MS data correspond directly to specific proteolytic enzymes present in each sample. On the other hand taking the splitting reaction (coming from endopeptidase cleavage A → B + C) into account significantly complicates the mathematical description. There is no analytical solution of the CME as in [5]. Instead we calculate the expected amount of peptides in the stationary state of the process. Those values are compared to the MS readouts for the corresponding peptides. The model parameters are calculated to minimize the discrepancy between expected and observed amount of each peptide.
Organization of the paper
We start by description of our model presented with the use of so called cleavage graph, then we present computational methods to interpret MS data (to fill the graph with appropriate readouts values) and to infer the model parameters. The constrained optimization problem is formulated and solved with Levenberg-Marquadt [8] algorithm. We estimate the convergence and statistical significance of estimation procedure outcomes. Finally, identified active peptidases for both groups of healthy donors and colorectal cancer patients are presented. A preliminary version of this paper was presented at 1st IEEE International Conference on Computational Advances in Bio and medical Sciences (ICCABS 2011). In this extended version we have significantly modified the Results section, by updating the MEROPS data, fixing some errors in scripts for data preprocessing and presenting more statistical analyses.
Model of proteolysis process
To illustrate the process of peptide degradation we introduce the cleavage graph, whose vertices correspond to peptides and proteolytic events. More formally, consider the bipartite digraph, , where the first set (peptide nodes) corresponds to all subsequences of the peptides considered and the second set of event nodes corresponds to all possible proteolytic events.
By proteolytic event we mean the cleavage of a specific substrate at specific site made by a specific peptidase. Hence each event node is labelled by a peptidase, and has one ingoing edge and two outgoing edges (leading to peptide prefix and suffix obtained by cutting the substrate at a single site).
Now we visualize the peptide subsequences as particles placed at peptide nodes of the cleavage graph. The particles are flowing through the edges of the graph according to the Petri net operational semantics, i.e. the transition (event node) consumes one substrate particle, and produces two particles. To assure the stationarity of the system we allow for creation and degradation of particle at any node. We also add the source and the sink in the graph modeling the creation of precursor peptides (e.g. caused by the activity of some endopeptidases, which is not captured by our model) and complete degradation of short peptides. The cleavage graph is constructed for every processed MS sample. The peptide nodes are appropriately filled with mass spectrometry readouts and specific enzymes are assigned to event nodes according to data about real cleavage events (see the next section for details).
where is an activity of creation the sequence represented by v, is a degradation activity, and are expected amounts of peptides and , is an affinity coefficient and is the activity of cleaving by the peptidase engaged in the cleavage . Left hand side of the equation above refers to the sum of particles that flow into the node , while right hand side to the sum of particles that flow out from this node. From the balance equation above one can easily calculate the expected number of particles in every peptide node .
In this section we describe the process of cleavage graph construction. It has several phases: firstly the set of nodes are determined. Peptide nodes correspond to the sequences identified in tandem MS experiment, while event nodes are selected carefully according to the knowledge from MEROPS database (version 9.4.). During the second stage the graph should be filled with appropriate readouts from LC-MS spectra. To this aim we have to determine which signal in two-dimensional spectral map corresponds to a given peptide sequence (i.e. node in the graph) and to assign to this node the number of particles reflecting the signal strength.
Having the cleavage graph we solve the constrained optimization problem to infer the unknown enzyme activity coefficients which minimize the discrepancy between expected number of peptides (calculated according to the model) and the observed signals in MS samples.
Cleavage graph construction
Let us define the set of amino acids together with the space letter and the set of loci surrounding (4 from both sides) the cleavage site .
Using frequency matrix we construct so called sequence logo [10] to represent the consensus sequence surrounding given cleavage site. Then for any peptidase we detect the cleavage event cutting given peptide sequence if it matches the consensus sequence well. For more detailed description see Web Supplement (http://bioputer.mimuw.edu.pl/papers/proteolysis/).
Affinity coefficients
Let us consider cleavage made by peptidase . Assume, that the cleavage point is surrounded by the sequence of amino acids (possibly with some empty positions at the ends) where .
Filling the graph with LC-MS readouts
MS samples were acquired from the blood serum of 20 colorectal cancer patients and 19 healthy donors. Each sample was digested by trypsin before LC-MS processing. Having so called precursor peptides (which were sequenced by tandem MS), we determine all their subsequences that can be observed during the cleavage process; they form the peptide nodes of the cleavage graph. To this end we digest the precursor peptides in silico using the set of human enzymes from MEROPS.
Then we look for corresponding signals in MS spectra as follows: using mz2m tool [11] we obtain a list of mono-isotopic peak coordinates (m/z, retention time and charge) together with their intensities. The search is processed for each sequence charged by each of eight possible charges (values from 1 to 8) detected by FTICR spectrometer. Expected value of retention time for each peptide is predicted from its amino acid composition by linear regression model [12] (trained by the set of known retention times for precursor peptides). Then we look for MS signals that are closest to expected ones (nearest neighbor classifier) and their distances do not exceed given threshold. Notice, that we ignore LC-MS signals corresponding to peptides not sequenced by tandem MS and theirs degraded forms. Therefore we use only partial information about degradation scheme, and possibly the activity of some enzymes engaged in the process cannot be inferred. By applying this procedure we fill many peptide nodes by appropriate peptide amount. However a large percent of the nodes remain empty. Finally, we prune the cleavage graph by removing recursively empty sources and empty leaves.
Constrained optimization
- 1.
if then ,
- 2.
if and then ,
- 3.
if then .
The graph pruning grants that , and the topological ordering assures that the function is well-defined.
Denote by y i the amount of peptide sequences identified in LC-MS/MS experiment in the i-th peptide node, and by set of vertices with . We solve non-linear least squares problem with objective function defined for each by the formula , which is well formulated and solvable for (fortunately holding in our case for all investigated MS samples). We applied Levenberg-Marquadt algorithm (LMA) [13] to find optimal configuration of model parameters.
Compositional data
The optimization procedure was applied to infer the enzymatic activity for 39 LC-MS samples, i.e. for each sample we obtained optimal parameters .
where and .
Adequacy of the model
Statistical significance of estimation quality
Final relative squared errors (rse) and p-values (calculated from rse distribution).
final rse
final rse
< 0.001
< 0.001
< 0.001
Biological significance of inferred enzymes
Heatmap in Figure 6 presents the activities of peptidases identified for these samples. Hierarchical clustering of activity profiles groups samples into clusters being in good accordance with patient's diagnosis. The diverse serum proteolytic activity for cancer patients and healthy donors has been reported in many papers (see e.g. [3]). In [16] has been showed that patients exhibit different enzymatic activities than healthy subjects for following peptidases (identified by our method as well): trypsin, cathepsin D and elastase (c.f. Figure 6). We have also detected the family of matrix metallopeptidases, whose role in cancer development and progression is significant [17, 18]. Similarly calpain enzyme is used as a marker for the early detection of colorectal carcinoma [19] and inhibitors of cathepsins as possible therapeutics in colorectal diseases [20]. Moreover, cathepsins (because of their ability to degrade extracellular matrix proteins) have been implicated to play a role in invasion and metastasis of colorectal cancer.
In this paper we significantly extend formal model of protein degradation proposed in [5]. The extension is twofold: firstly current approach encompasses endopeptidase activity as well (while [5] deals with exopeptidases only), and secondly we integrate our model with knowledge about proteolytic events stored in MEROPS database [6]. Moreover, we formulate the task of inferring parameters of our model as constrained optimization problem, which we solve by standard procedure for non-linear least squares. This approach turned out to be more time efficient for complex MS data when comparing to previous Markov Chain Monte Carlo method (in [5] the Metropolis-Hastings algorithm was applied to sample parameters from the posterior distribution).
Being aware of the problems with quality and reproducibility of the LC-MS experiments we selected for detailed analysis only a part of accessible data, namely those for which the parameter estimation procedure converges and yields small error. The expected retention time for investigated substances is obtained by rather unsophisticated approach (i.e. linear regression model), which may have impact on the analysis. Preliminary outcomes for these samples are very promising: identified enzymes are known to play a crucial role in colorectal cancer. However, our results are far from any medical diagnosis. The proposed method constitutes the proof of concept and requires more profound investigations meeting all clinical standards. We also should discuss here the limitations of our methods applied to MS data obtained by present technologies. There is a lot of tryptic peptides which are not identified by tandem mass spectrometry. LC-MS signals corresponding to these peptides and theirs degraded forms are missed during cleavage graph filling phase. Therefore the inference of proteolytic enzymes' activities is based on only partial information and could be incomplete as well. However, it is worth to noting here that our method would demonstrate its full potential while applied to high quality data hopefully obtained from the future MS technologies. One direction for further development is to focus on cleavage detection and to apply recently proposed ice-logo instead of sequence logo [21]. Ice-logo contains the information not only about residues that are statistically overrepresented but also about those, that are underrepresented. This approach could be valuable especially in cases, when, as in the case of data stored in MEROPS database, we know only fraction of all proteolytic events.
The authors would like to thank Neil Rawlings for helpful information about MEROPS and Bogusław Kluge for the source code from [5]. This research is supported in part by Polish National Science Center grant DEC-2011/01/B/NZ2/00864. PD is currently supported by the EU through the European Social Fund, contract number UDA-POKL.04.01.01-00-072/09-00.
This article has been published as part of BMC Bioinformatics Volume 13 Supplement 5, 2012: Selected articles from the First IEEE International Conference on Computational Advances in Bio and medical Sciences (ICCABS 2011): Bioinformatics. The full contents of the supplement are available online at http://www.biomedcentral.com/bmcbioinformatics/supplements/13/S5.
Authors' Affiliations
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- Diamandis EP: Proteomic patterns in biological fluids: Do they represent the future of cancer diagnostics? Clin Chem 2003, 49: 1272–1275. 10.1373/49.8.1272View ArticlePubMedGoogle Scholar
- Villanueva J, Shaffer DR, Philip J, Chaparro CA, Erdjument-Bromage H, Olshen AB, Fleisher M, Lilja H, Brogi E, Boyd J, Sanchez-Carbayo M, Holland EC, Cordon-Cardo C, Scher HI, Tempst P: Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest 2006, 116: 271–284.PubMed CentralView ArticlePubMedGoogle Scholar
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- Amiguet J, Jiménez J, Monreal J, Hernández M, López-Vivanco G, Vidán J, Conchillo F, Liso P: Serum proteolytic activities and antiproteases in human colorectal carcinoma. J Physiol Biochem 1998, 54: 9–13.PubMedGoogle Scholar
- McKerrow JH, Bhargava V, Hansell E, Huling S, Kuwahara T, Matley M, Coussens L, Warren R: A functional proteomics screen of proteases in colorectal carcinoma. Molecular Medicine 2000, 6(5):450–460.PubMed CentralPubMedGoogle Scholar
- Sugimoto M, Furuta T, Kodaira C, Nishino M, Yamade M, Ikuma M, Sugimura H, Hishida A: Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan. Journal of Gastroenterology 2008, 43: 751–761. 10.1007/s00535-008-2221-6View ArticlePubMedGoogle Scholar
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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On Sunday, University of Missouri defensive end Michael Sam was rated as the 90th-best prospect in May's National Football League draft. The next morning, the 24-year-old all-American had slipped to No. 160.
Only one thing had changed: On Sunday night, Sam announced he is gay.
If he's drafted, Sam would become the only openly gay active player in any of the four major professional sports.
Suddenly, NFL teams are weighing real questions about Sam's size, speed and ability — and whether his skills will be enough to overshadow the almighty "distraction," a catch-all term many teams use when addressing an issue, personality or incident they'd rather not deal with. In this case, teams will weigh whether Sam's play merits the massive media attention and possible objections from teammates and others.
"There's going to be a lot of questions," said Gil Brandt, a former executive who's now an NFL Network analyst. ". . . I would imagine that right now, everybody's got their tapes from Missouri queued up, and they're looking at [jersey] number 52."
While many welcomed the news as a landmark in the world of professional sports — among those tweeting congratulations was President Obama — Sam's announcement also was met with a good measure of public and private skepticism in the NFL community.
It suggested that although Americans are more accepting of gay rights, the nation's favorite sport has been slow to shed its apprehension — an image some team leaders are trying to change.
"Regardless of who you are, what your background is and what your personal or sexual orientation is, if you can play, you can play," New York Giants President John Mara said Monday in comments provided by the team. "Michael's announcement will not affect his position on our draft board."
The Giants could be in the minority. Two weeks ago, as Sam was among a group of players preparing for a pre-draft all-star game, the Senior Bowl, rumors circulated that there were red flags surrounding the Missouri defender.
"I think the way it was put was: 'Sam may have some off-the-field problems,' " Brandt said. "Quite honestly, I didn't know what that meant."
Before Sunday's announcement, the Southeastern Conference's co-defensive player of the year was projected as a possible third-round pick; CBS Sports had rated him 90th, then No. 160 and later Monday moved him to No. 110.
But Peter King, who writes a popular NFL column for Sports Illustrated, quizzed several team officials about Sam on Sunday; one said his announcement wouldn't matter, but another predicted Sam wouldn't be drafted at all. Brandt, pointing to Sam's undersize upper body and inexperience as a starter, predicted that Sam would be selected in the sixth round; the past seven SEC defensive players of the year have been taken in the first round.
Even if Sam possessed first-round talent, Brandt said, his announcement likely would've cost him selection in the first round.
Wade Davis, a former NFL defensive back who came out as gay after his career ended, was among a small group that prepped Sam this past weekend for Sunday's announcement. Davis said by phone that Sam did not express concern that coming out would hinder his professional career.
"He wasn't worried about it," said Davis, who spent one season with the Washington Redskins and now is the executive director of You Can Play, an advocacy group that works for equality among gay and transgender athletes. "One thing that Michael told me: 'Look, man, I can play.' . . . Those guys [NFL players] only care about one thing: Can you help us win?"
Sam, who came out to his college team before the 2013 season, led Missouri to the SEC East championship and a 12-2 record. He tallied 111 / 2 sacks and 19 tackles for losses. Despite his strong season and the Tigers' surprising run, Sam rarely spoke with reporters; his teammates, meanwhile, kept his secret.
"I never had a problem with my teammates," Sam was quoted as saying in the New York Times, which along with ESPN was the platform for his revelation. "Some of my coaches were worried, but there was never an issue."
Still, a handful of NFL players have expressed reluctance at playing alongside a gay teammate. Patrick Crayton, a veteran wide receiver who spent the 2013 preseason with the New Orleans Saints, tweeted Sunday night that Sam should "stay in the closet." Jonathan Vilma, a Saints linebacker, said during an NFL Network interview last week that he had concerns about showering and dressing with a gay teammate nearby.
Doug Williams, himself a social pioneer as the first black quarterback to win the Super Bowl, said Monday that Sam's on-field ability should overshadow any preconceptions in the locker room.
"Eventually, we have to get to that point when we talk about people's sexuality and get to that point where you say: 'Hey, that's their preference, but if he's a good football player, and if he can help us win, he can be on my team,' " said Williams, who on Monday joined the Redskins in a front-office position.
Davis, the equality advocate, said Sam expects to be hazed, a rite of passage endured by many NFL rookies, particularly those with a high national profile.
Davis said Sam told him last weekend that, if a teammate asks about Sam's sexuality, he would discuss it openly. And the first step toward earning his teammates' trust, Davis said, would be in keeping locker-room conversations — and potentially insensitive language — private. A similar approach could be seen as Sam's first NFL test: At the NFL combine, a talent evaluation event held in late February, team officials surely will ask him questions about his sexuality, a topic officially off-limits, and keeping those questions confidential could earn him points in the close-to-the-vest NFL.
"The thing he knows is that, 'Hey, I'm not looking to run to the media and tell them this guy asked me this question,' " Davis said. "He understands the importance of that. He knows he has to not only protect himself but the brand, and if he wants to be a part of that brand, he's got to look out for that."
After the draft, it'll be up to Sam's new team to manage what follows. Last year, the San Diego Chargers drafted Notre Dame linebacker Manti Te'o in the second round, months after it was revealed that Te'o had been tricked into carrying on an online romantic relationship with a woman who didn't actually exist. Before the draft, Chargers officials met to discuss a media strategy; they would limit exposure to reporters and allow no one-on-one interviews.
After the draft, the team maintained its plan, and with Te'o willing to address questions head-on, a previously dominant story line dissolved after a few months.
Davis said Sam seemed ready to answer all questions without reservation, too. That began Sunday, when he stepped in front of the rumors circulating at the Senior Bowl and, rather than face relentless questions about his "off-the-field problems," as it had been put to Brandt, Sam provided his own answers.
"I think he did the right thing," Brandt said. "Because they would ask him about it, and then if he didn't admit it and lied, it would hurt him more. This way, it's out there."
Now, Davis said, he can prepare answers for a more pressing topic: Whether he belongs in an NFL team's lineup.
"He's such a football guy," Davis said, "that that's all he wants to talk about: 'Hey, I just want to play football. Can you line up a guy in front of me who can stop me?' "
Mike Jones contributed to this report.


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Do Not Want
New version with 50% less lolcat!
So many unappealing choices. So little time to communicate that to the unwashed masses. Tell folks without saying a word that you "Do Not Want" whatever they have to offer.
Face it -- there are so many opportunities in your life for this shirt. We made it just for you, because we feel your pain, your need to cry out, "DO NOT WANT" to so many things. Do Not Want is part of our tribute to LOLCats. (And Backstroke of the West... you didn't think we'd forget the origin, did you? Especially if it had to do with Star Wars. Clearly you underestimate us, young Padawan.) Maybe you should get a small for your cat. Cause you know that'd be your cat's sentiment if you tried to make the cat wear it....
We predict that wearing your Do Not Want shirt will come in handy in everyday situations. Salmonella? Do Not Want. Jury summons? Do Not Want. Screaming baby in the seat next to you on the airplane? Do Not Want. Soda on your keyboard? Do Not Want!
"Do not want" printed in white on this black, 100% cotton shirt. Machine wash cold. Tumble dry low or lay flat to dry. Imported.


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More than half of respondents to this week's RBJ Daily Report Snap Poll say social media use is important in their business.
Of these, a quarter regard social media as very important and 29 percent as somewhat important. This compares with 24 percent who say social media use is not very important to their business and 22 percent who say it's not important at all.
The social networking website LinkedIn, 10 years old this month, now has more than 200 million users. The plurality of respondents-37 percent-picked LinkedIn as most useful to their businesses.
Other social media have grown even more rapidly: 9-year-old Facebook has more than 1 billion users, and Twitter has reached 200 million users less than seven years after its founding.
A quarter of readers cited Facebook as the social media site most valuable to their businesses; Twitter followed with 8 percent and Google+ with 5 percent.
One-fifth of respondents said their businesses do not rely on social media.
Many individuals use social media for career- and job-related networking. In addition, as use of social media has mushroomed, many companies have turned to the sites for a range of business purposes such as marketing, public relations, customer service and hiring.
More than half of respondents said their businesses use social media for marketing, public relations and sales.
A quarter said social media were useful for customer feedback and service, and 21 percent use these sites to track industry competitors.
A fifth of readers use social media to get ideas for new products or services and for recruiting and background checks on employment applicants.
Nearly 325 readers participated in this week's poll, which was conducted May 13 and 14.
How important is social media use to your business today?
Very important: 25%
Somewhat important: 29%
Not very important: 24%
Not at all important: 22%
Which social media site is most useful to your business?
LinkedIn: 37%
Facebook: 25%
Twitter: 8%
Google+: 5%
YouTube: 2%
Other: 1%
None: 20%
For what purposes does your business use social media?
Marketing/PR and sales: 56%
Customer feedback and service: 25%
Tracking industry competitors: 21%
Gathering ideas for new products or services: 20%
Hiring (recruiting, background checking): 20%
Other: 11%
Regardless of what measurable benefit in terms of sales and profits, in this day and age, if you're not actively in the social media game, then you are viewing from the sidelines and risk your competition taking the upper hand.
—Mark Cleary
I would like to announce the launching of a social media site for older Web users. It will be called "FaceLift." All pictures will be on film, rules of English grammar will be enforced, and if you send a message in all caps, it only means you left the caps lock on.
—Bill Lanigan
Facebook, along with the Internet and email, allows us to stay in contact with all our guests by advertising, reserving rooms and posting activities at our bed and breakfast, the Genesee Country Inn.
—Richard and Deborah Stankevich, Genesee Country Inn, Mumford
Social media are simply additional tools that can be used for a variety of purposes. Like any other medium, results may vary depending on usage.
—Peter J. Gregory, Rochester
If you have an audience or group of customers or clients that you regularly interact with, you need to be touching base with them with some regularity. Social media is an excellent way, but don't forget about face-to-face time.
—Rich Calabrese Jr., Rochester
The ability to spread information has exploded through social networking sites. The immediate ear of media is a plus to non-profits whose marketing budgets may be limited.
—Cheri Trimble Miller, Hochstein School of Music & Dance
5/17/13 (c) 2013 Rochester Business Journal. To obtain permission to reprint this article, call 585-546-8303 or email email@example.com.


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The Wanted Premiere 'Show Me Love' on 'X Factor U.K.' [VIDEO]
The Wanted are gearing up for their world tour and new album, pulling out all the necessary stops to get on top. The boy band performed their latest U.K. single, 'Show Me Love,' on 'X Factor U.K.' -- the "birthplace" of rivals One Direction!
The five-piece opened the performance with Nathan Sykes at a piano. He was soon joined by bandmates Siva Kaneswaran, Jay McGuiness, Tom Parker and Max George, harmonizing the wistful breakup ballad beautifully. They were flanked by a fiery curtain that framed their all-black ensembles beautifully.
At the conclusion of the performance, which showcased George, McGuiness and especially Sykes' vocals the most, Sykes revealed that he penned the tune himself. We bet he's happy his new lady, Ariana Grande, knows how to show him love!


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MT. MITCHELL survey launch -recovery efforts.
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What's on at Hamleys
Stay glued to our local What's On page and you'll never miss any of the action
A Magical World
If you're planning a trip to one of our Toy Shops why not check what's on that week. Every day is a magical day at Hamleys! Join in the fun with our Experience Team as we Bring Toys to Life!
See What's on at your local store!


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Available Languages
Other Organizations and Related Websites
More cancer information for Asian and Pacific Islander communities may also be available through the following organizations:
American Cancer Society California Chinese Unit
Describes the history and current activities, including Relay For Life and Tell A Friend, of the volunteers of the American Cancer Society California Chinese Unit. Links to additional websites of interest are also provided.
Asian American Network for Cancer Awareness, Research, and Training
The first Asian American Special Population Network funded by the National Cancer Institute. The goal of AANCART is to build a robust and sustainable infrastructure to increase cancer awareness, research, and training among Asian Americans in order to reduce the burden of cancer among Asian Americans.
Asian Liver Center at Stanford University
The Asian Liver Center at Stanford University is the first non-profit organization in the United States that addresses the high incidence of hepatitis B and liver cancer in Asians and Asian-Americans. Founded in 1996, the center uses a three-pronged approach towards fighting hepatitis B through outreach & education, advocacy, and research.
Chinese Community Health Resource Center
Chinese Community Health Resource Center (CCHRC) was established in 1989 as a private, non-profit community center by The Chinese Community Health Care Association (a physicians' independent practice association), Chinese Community Health Plan, and Chinese Hospital. The Center's mission is to build a healthy community through culturally and linguistically competent preventive health, disease management, and research programs.
Harborview / EthnoMed
Harborview Medical Center is the county hospital in Seattle, Washington. At Harborview, the Refugee and Immigrant Health Promotion Program's (RIHPP) mission is to improve the health of the refugee and immigrant communities served by the hospital. RIHPP collaborates with the Health Sciences Library at the University of Washington to manage and produce content for EthnoMed, a nationally recognized web site dedicated to providing information about refugee and immigrant health care issues.
Health is Gold!
Vietnamese Community Health Promotion Project, University of California, San Francisco. The mission of Health is Gold! is to improve the health of Vietnamese living in the United States. The mission is accomplished through various strategies including working with community members to identify salient health problems, developing community-based, culturally-appropriate interventions with Vietnamese community participation, evaluating the interventions using rigorous scientific research methodology, and disseminating the research results for replication.
Hepatitis B Foundation
A national non-profit organization dedicated to finding a cure and improving the quality of life of those affected by hepatitis B worldwide through research, education, and patient advocacy. Information on this website is available in Chinese (simplified), Chinese (traditional), Korean, Vietnamese, and Spanish.
'Imi Hale - Hawaiian Cancer Network
'Imi Hale is a 10-year project funded by the National Cancer Institute - Center to Reduce Cancer Health Disparities aimed at reducing the burden of cancer among Native Hawaiians.
Immunization Action Coalition
The Immunization Action Coalition works to increase immunization rates and prevent disease by creating and distributing educational materials for health professionals and the public that enhance the delivery of safe and effective immunization services.
National Cancer Institute
Coordinates the National Cancer Program which conducts and supports research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention and treatment of cancer, rehabilitation from cancer, and the continuing care of cancer patients and the families of cancer patients. Information is currently available about cervical cancer screening in Vietnamese translation, and on the importance of regular mammography for women ages 40 and older in Chinese, Tagalog, and Vietnamese translations.
SPIRAL: Selected Patient Information Resources in Asian Languages
SPIRAL is a joint initiative of the Tufts University Hirsh Health Sciences Library and the South Cove Community Health Center. SPIRAL provides access to consumer health information in the following Asian languages: Chinese, Hmong, Khmer, Korean, Laotian, Thai, and Vietnamese. It also contains links to a variety of Asian and Pacific Islander health resources.
Weaving an Islander Network for Cancer Awareness, Research and Training in Southern California (WINCART) is a consortium of community-based groups and interdisciplinary researchers, representing public health, community and health psychology, cancer epidemiology, preventive medicine, anthropology, health communication, and health policy with a common goal to reduce cancer disparities among Pacific Islander (PI) groups in Southern California.


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Completely Objective Biography by M. McDonald
Michael McDonald is not a singer. That's the other guy. He is also not a professional fighter. That's the other other guy. He's also not an abusive unemployed alcoholic. That's some of the rest of the Michael McDonalds out there. You've found the one who is best known for his ten years playing freaks on Mad TV. Michael got his start writing and performing for free at the famed Groundlings Theater in Los Angeles. His first paid writing and acting jobs came from Concorde Pictures, Roger Corman's infamous low-budget movie studio. Starting as an extra, McDonald landed dozens of roles in terrible movies. He eventually moved behind the camera to write and direct more terrible movies. Roger Corman still owes Michael money. Since those early poverty stricken years, Michael has divided his career into as many tiny hard-to-reassemble pieces as possible:
Michael has usually worked in television, landing guest spots on SEINFELD, ELLEN, JUST SHOOT ME, and NEWS RADIO before landing on MAD TV in 1998. During his ten-year run, McDonald created several weird characters - most notably man-child Stuart Larkin, Marvin Tikkvah Rusty Miller, and The Depressed Persian Tow Truck Man. He was also forced to attempt many impressions, including Dr. Phil, Al Gore and most of the murders & politicians of that era. In 2007, McDonald left MAD TV because the wigs were really getting to him. He went on to guest star on more television shows, including SCRUBS, DESPERATE HOUSEWIVES, and PUSHING DAISIES. As of this writing by a completely impartial third party who has no connection to Michael what so ever, I – I mean Michael - currently has recurring roles on HOUSE OF LIES and WEB THERAPY. Both of these are on SHOWTIME, which means they are better than network shows, but they don't pay very well. Michael's first film role in years is as a bad guy in THE HEAT, starring Sandra Bullock and Melissa McCarthy. Watch for it in the summer of 2013.
Aside from the early days of directing crap for Concorde Pictures, McDonald took up directing again on Mad TV. It seemed like a natural thing to do, since he was always telling everybody what to do anyway. From there, he branched out to direct episodes of other shows in which he had previously worked as an actor, including SCRUBS, and SEVENTH HEAVEN. Eventually he became a producer/director on ABC's COUGAR TOWN, and guest director on DON'T TRUST THE BITCH IN APT 23, SAVE ME, and HOW TO LIVE WITH YOUR PARENTS. Directing actors has taught Michael that he should be nicer to directors when he is acting.
McDonald enjoys writing his own material, starting with those horrible Corman movies in the early days, to sketch comedy at the Groundling Theater, and then on MAD TV. In 2012, his first drama pilot, BEAUTIFUL PEOPLE, was produced for NBC but was not picked up because it was "too cool for TV." NOTE: It bears repeating that this is an unbiased, third-party assessment. Michael is currently working on another drama script through his deal with ABC Studios. Luckily, this one is guaranteed to be a hit – because it just has to be, damn it!
Whenever his schedule permits, (translation – frequently) McDonald tours the country doing stand up comedy. His first hour-long comedy special, MICHAEL MCDONALD: MODEL. CITIZEN. aired on SHOWTIME in 2010 and is currently available on AMAZON. Michael hopes to tape a second hour-long special before the end of 2013.
For a more complete list of Michael's many career highs (and even more lows) click here! http://www.imdb.com/name/nm0567912/
Sam Morril, one of the fastest-rising stand-up comics in New York City, is also one of the best joke writers in the scene today. How do you know that's true? Because he is writing this bio, and he wouldn't lie about that to get extra work.
In 2011, Sam won The Laughing Skull Comedy Festival in Atlanta and was named one of Comedy Central's "Comics to Watch." More recently, Sam has been seen on Comedy Central's Adam Devine's House Party, the Late Show with Stephen Colbert, and "Conan" on TBS for multiple appearances. He's also appeared on the Tonight Show with Jimmy Fallon and The Late Late Show with James Corden. He's done a lot of stuff.
Also, Last Comic Standing, America's Got Talent, @Midnight, and Inside Amy Schumer. Sam recorded his debut album on Comedy Central records, which went to #1 on iTunes and made numerous top 10 lists. He also released his very own half-hour Comedy Central special.
Sam was the host of his very own show on MSG called "People Talking Sports", which ran for two seasons and received an Emmy nomination. Emmy nominated, baby!
Sam also had the highest rated debut special on Comedy Central last year, "Positive Influence" — available at cc.com/sammorril
You can see Sam regularly at The Comedy Cellar in New York City, and some other clubs. He even pops into those pretentious indy hipster shows, and is regularly on the road hitting new cities.
Now is your chance to see Sam. Do it soon before you catch swine flu or something. It's out there!
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text:
Brain drain—the migration of talent across borders—has an impact on Malaysia's aspiration to become a high-income nation. Human capital is the bedrock of the high-income economy. Sustained and skill-intensive growth will require talent going forward. For Malaysia to be successful in its journey to high income, it will need to develop, attract and retain talent. Brain drain does not appear to square with this objective: Malaysia needs talent, but talent seems to be leaving.
Brain drain is a subject of intense debate and controversy, but surprisingly few studies have characterized the phenomenon in the Malaysian context—be it in terms of magnitude, impact or policy response. What complicates matters further are the statistical discrepancies that limit the quality, availability, timeliness and comparability of international migration data.
In our most recent Malaysia Economic Monitor (available April 28, 2:00 pm Malaysia time), the Malaysian diaspora—the group of skilled and unskilled Malaysian-born women, men and children living overseas—is estimated conservatively at 1 million worldwide as of 2010. A third among these represent brain drain—those with tertiary education among the diaspora. This is not to suggest that others are not 'brainy', but educational attainment is the only available proxy that is consistently available across recipient countries.
To put the numbers in perspective two factors are important: the size of the skills base and the profile of immigration. Because of the narrow skills base, brain drain is intense in Malaysia and is further aggravated by positive selection effects, as the best and brightest leave first. Further, brain drain is not alleviated by compensating inflows, since migration into Malaysia is mainly low-skilled with some 60 percent with primary education or less and the number of high-skilled expats has fallen by a quarter since 2004.
How can policymakers address the brain drain? The challenge for Malaysia, as for many other countries, is to embrace the global mobility of talent. As Malaysia needs talent, it will need to turn the brain drain to its advantage.
Malaysia needs to tackle the underlying determinants of brain drain. Brain drain is a symptom—an outcome of underlying, more fundamental factors. Identifying the factors that drive people to migrate is the first step towards formulating policy responses to brain drain.
Among the factors that matter in Malaysia are differences in earnings potential, career prospects, quality of education and quality of life, relative to overseas locations. However, discontent with Malaysia's inclusiveness policies is a critical factor too—particularly among the non-Bumiputeras who make up the bulk of the diaspora.
The productivity and inclusiveness agendas are well understood and policy frameworks have been well-articulated in Malaysia's transformation programs. Forceful implementation of these programs should assist in strengthening both the demand and supply side of the market for talent, so that productivity and wages levels can rise in tandem. This will also reduce the incentive to emigrate and help attract talent from abroad. Progress on updating Malaysia's inclusiveness strategies will be equally important as this is perceived by the diaspora as a key push factor that fuels the incentive to leave and serves as a deterrent to return.
Once the enablers are in place, targeted measures are helpful to further facilitate the flow of talent and engage with the diaspora in other ways than through the physical flow of people. However, these targeted measures cannot substitute for more comprehensive measures outlined earlier. Malaysia's Talent Corporation is developing new initiatives and recent measures, such as the Residence Pass and Returning Experts Programme, are encouraging. The challenge going forward will be to also find effective ways to connect with the diaspora—as interest is more easily raised than sustained. One immediate example of engaging might be to seek the diaspora's input on how Malaysia can make a leap forward in embracing the globalization of talent and turning brain drain to its favor.
Photo courtesy of Syafiq Sirajuddin (Pheeque)
Where the brain
Brain drain is the issue here
It's all about WHERE THE BRAIN IS!!!!
Thank you / Malaysia as a Crèche
Opposite flows
Malaysian Brain Drain
Recurrent problem
Obvious Answers
I am a Malaysian, and proud
I am a Malaysian, and proud and feel so great to be born here - absolutely! I went to local public schools during the era of Dr. Mahathir and earned degrees from both local and from the UK universities. I'm sure our education system among the best and I'm sure the policy makers will continue to formulate policies which will further enhance the quality of life here.
See, developing countries need to educate themselves about what is brain drain is all about, why it has to happen now, what implication and etc. Just like people learn to know what is HIV and do not fear to let them live among us as usual. All SEA countries are facing brain drain issues at the moment; be it Malaysia, Singapore, Thailand, Indonesia etc. So, it is not really about which country will gain more brainy people going into their country or vice versa.
Countries shouldn't be continued debating about it - no point, should stop. They (through the existing community example ASEAN), they could collaborate how they can maximize and craft our own definition of brain drain; find ways to mould the strategy or stimulation package. An absolute example, as such as Talent Corp of Malaysia; but the current program which they are doing just need to make it a little global friendly. Remember.. Today's global organization is about being Green-friendly. Well same principle applies to Brain Drain. Many government today perceive Brain Drain as something they fear and disadvantage to their administration. How to tackle this then? Very simple indeed.. Blue Ocean is about how McDonalds could craft magnificent value meals around the world but they still can be rich and pay back tax to their own country. Some of a basic example, maybe if you a Malaysian working for an Indonesian company, you will get a free car, free insurance etc. Travel to Indonesia with no visa.
Let the brainy brains floating within the boundaries that we as the policy makers, the capitalist, the economist, the managers decide where it should benefit, then we can be powerful and enrich each other not to fear living next to each other, like some country does. One must remember and learn this one thing ( i learnt this from Winston Churchill, Hikayat Hang Tuah and Doctor in the House) that... last time who has more lands / owns more natural resources is the Man of the time. But today, you need to duplicate your 'natural resources' which is your brain so that you will win the battle (Winston Churchill) and will never go misguided because religion ask you to share your knowledge and be thankful to your idea makers (Hang Tuah) so that you could live rich by first making sure others who lives around you can also get rich too (of course by maximizing opportunity, flexibility and promote a balance life while not to fear about losing brainy workers). It will be a new approach on how capitalist system should be manipulated today. In fact it can be administered rightly for our own benefit and for the world). Do not fears change (Tun Mahathir).
To all, I am a brain-drainer, I work for a company which owns 30% by a leading Bumi company (thank you for such policy, we learnt from the Brit unwritten constitutional) and contribute works for an international publication (if that is to be called as brain drain, perhaps). I would say, may my kids will live anywhere in the world he likes, marry any Muslims anywhere in the world he loves and paying e-tax to a country he felt his patriotically faith is belong. So live no fear to Brain Drain. To Muslims - it's already written in the Quran, Allah asks you to Hijrah and see the world and be kind to all humans.. He already introduced globalization and Brain Drain policy...indeed and it is here now that's for us to admit His Almighty and He is just all around.
Your comment is like seeing
Your comment is like seeing the mote in other's eye, but not seeing the beam in our own eye. Obviously, you're Malaysian Malay or Malaysian Muslim citizen that know nothing about true democracy. The main problem is that the government isn't democratic but religious-fascist. Malaysian Malay people (muslims) are totally spoilt by their government so if you all wanna know about the true Malaysia, you should listen what Malaysian intellectual from Indian, Chinese and Aboriginal races have to say about this topic.
Thank u for ur opinion. Im
Thank u for ur opinion. Im not sure what is ur understanding of our malaysian democracy n constitution n which part of the world u r from or from which type of democracy practise u been rising from. But please let me know whether is it a good democracy or not in a country such as Malaysia... we have 10 billionaires, 8 are Chinese, 1 is indian, 1 is Malay. We have independent for almost 60 years now. And chinese n malay still can live with each other with us the 'spoilt' without hesitation...without anyone starvings. 3.4% is our unemployment rate. Who administer this.. sorry to inform you.. the malaysian muslim n yes most of us themalay, chinese n infdian. Can u tell me any chinese school with chinese school name that can be found in indonesia or maybe in the UK where officially they recognise the chienese education ...such as Malaysia do? Who allow this?.. obviosly the one that u refer to the 'spoilt' malaysia muslim? Your comment dont sound you have good grade in history or in economic study. Study more then. Take care.
In the mobile world there
In the mobile world there will always be a 'brain' drain. Malaysia is made up of Malays and Non-Malays. Which half makes the major part of this drain. Majority are from the latter grouping. Whilst many leave for financial betterment, there are large numbers from the latter group leave because of the discriminatory policies of the Government, in favour of the Malays, so-called Bumiputras or Sons of the soil in education and opportunities. Eg. nearly all top civil service jobs are the preserve of the Malays. Only by changing this pro-Malay policy will the country reverse the brain drain.


text:
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The Oxford Faux Leather Bed Frame is a single low foot end design which features simple straight lines and a very durable hardwood mix construction.
It is fully upholstered in luxurious Brown faux leather with a single vertical stitch line in the head board. The Oxford also boasts a high resistance posture sprung slatted base to improve mattress longevity.
The Oxford is perfectly at home as a single bed frame or perfect for that spare/guest room bed.
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